title: Synergistic effect of quercetin and quinic acid by alleviating structural degeneration in the liver, kidney and pancreas tissues of STZ-induced diabetic rats: a mechanistic study.
abstract: The aim of this study was to investigate the synergistic effects of quercetin (QE) and quinic acid (QA) on a STZ-induced diabetic rat model to determine their potential role in alleviating diabetes and its associated complications. In our study design, diabetic rats were treated with single and combined doses of QE and QA for 45days to analyse their effects on liver, kidney and pancreas tissues. The study result showed that QE and QA treated groups down-regulated hyperglycaemia and oxidative stress by up-regulating insulin and C-peptide levels. Moreover, histological observations of the liver, kidney and pancreas of diabetic rats treated with single and combined doses of QE and QA showed a significant improvement in the structural degeneration. Interestingly, the combination dose of QE and QA (50 mg/kg) exhibited maximum inhibition of the pro-apoptotic protein Bax expression and demonstrate enhancement of the anti-apoptotic protein Bcl-2 expression in the kidney tissues, suggesting a protective role in the kidneys of diabetic rats. Taken together, these results indicates the synergistic effects of QE and QA in ameliorating hyperglycaemia, hyperlipidemia and insulin resistance in diabetic rats and therefore, open a new window of research on the combinatorial therapy of flavonoids.
authors: Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: adityaarya18@gmail.com.
authors: Aditya
authors: A
authors: Arya
authors: Center of Studies for Periodontology, Faculty of Dentistry, University Technology MAR (UiTM), 40450 Shah Alam, Selangor, Malaysia.
authors: Mazen M Jamil
authors: MM
authors: Al-Obaidi
authors: Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors: Nayiar
authors: N
authors: Shahid
authors: Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors: Mohamed Ibrahim
authors: MI
authors: Bin Noordin
authors: Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors: Chung Yeng
authors: CY
authors: Looi
authors: Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors: Won Fen
authors: WF
authors: Wong
authors: Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors: Si Lay
authors: SL
authors: Khaing
authors: Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors: Mohd Rais
authors: MR
authors: Mustafa
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D004357:Drug Synergism; D004798:Enzymes / Q000097:blood; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D010179:Pancreas / Q000187:drug effects* / Q000473:pathology; D011794:Quercetin / Q000494:pharmacology*; D011801:Quinic Acid / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin
chemical_list: D000975:Antioxidants; D004798:Enzymes; D011801:Quinic Acid; D008315:Malondialdehyde; D013311:Streptozocin; D011794:Quercetin
keywords: Diabetes mellitus; Quercetin; Quinic acid; Streptozotocin; Synergistic effect