title: Outcome of renal transplantation from deceased donors: experience from developing country.
abstract: BACKGROUND
  In India, there are a large number of end-stage renal disease (ESRD) patients waiting for renal transplantation (RT). Organ retrieval from brain dead deceased donor (DD) is getting increased attention as the waiting list for organ recipients far exceeds the organ donor pool. In our country, despite a large population, the number of brain dead donors undergoing organ donation is very less. DDRT is the possible solution to bridge the disparity between organ supply and demand. In India, the potential for DDRT is huge due to the high number of fatal road traffic accidents and this pool is yet to be tapped.
  
  
  METHODS
  We report DDRT outcome in 294 patients (age: 36.5 ± 14.1 years; male:female, 200:94) between 2005 and 2012. All patients received single-dose rabbit-anti-thymocyte globulin for induction and steroids, calcineurin inhibitor, and mycophenolate mofetil/azathioprine for maintenance immunosuppression.
  
  
  RESULTS
  Our retrospective study in 294 DDRT shows a fairly successful outcome. Over a mean follow-up of 3.93 years, patient and graft survival rates were 81.7% and 92.6%, respectively, with a median serum creatinine of 1.5 mg/dL. 20.7% had biopsy-proven acute rejection.
  
  
  CONCLUSIONS
  Given the widespread organ shortage, DDRT has a potential to expand the donor pool and shorten the waiting list for RT, encouraging the use of this approach even in low-income countries. Aggressive donor management, increasing public awareness about the concept of organ donation, good communication between clinician and the family members, and a well-trained team of transplant coordinators can help in improving the number of organ donations.
authors: Department of Nephrology and Clinical Transplantation, Institute of Kidney Diseases and Research Center, Dr. HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS) , Ahmedabad , India .
authors: Vivek B
authors: VB
authors: Kute
authors: Aruna V
authors: AV
authors: Vanikar
authors: Himanshu V
authors: HV
authors: Patel
authors: Pankaj R
authors: PR
authors: Shah
authors: Manoj R
authors: MR
authors: Gumber
authors: Divyesh P
authors: DP
authors: Engineer
authors: Pranjal R
authors: PR
authors: Modi
authors: Syed Jamal
authors: SJ
authors: Rizvi
authors: Veena R
authors: VR
authors: Shah
authors: Manisha P
authors: MP
authors: Modi
authors: Kamal V
authors: KV
authors: Kanodia
authors: Hargovind L
authors: HL
authors: Trivedi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002102:Cadaver; D002648:Child; D002675:Child, Preschool; D003906:Developing Countries; D005260:Female; D006801:Humans; D007194:India; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014019:Tissue Donors; D016896:Treatment Outcome; D055815:Young Adult
keywords: Deceased donor; developing country; end-stage renal disease; outcome; renal transplantation