title: Effects of change in the formulation of lanthanum carbonate on laboratory parameters.
abstract: Lanthanum carbonate (LC) is available in the two formulations of chewable tablets and granules. In this study, we changed the formulation of LC from chewable tablet to granules, and compared the laboratory parameters for 3 months before and after changing formulation in 58 hemodialysis (HD) patients. We also surveyed patients about their preferences for the two formulations. The mean serum phosphorus (P) levels decreased significantly (P < 0.01) from 6.7 mg/dL to 6.4 mg/dL after the change. The levels for serum albumin and geriatric nutritional risk index increased significantly (P < 0.01). Serum calcium levels also increased significantly (P < 0.01), while serum intact parathyroid hormone levels decreased significantly (P < 0.01). In the survey, approximately half of the patients responded that the granules were easier to take than the chewable tablets. These findings suggest that changing the formulation of LC to granules may reduce serum P levels of the HD patients in clinical practices.
authors: Department of Internal Medicine, Maruyama Hospital, Shizuoka, Japan.
authors: Takako
authors: T
authors: Takita
authors: Mitsuyoshi
authors: M
authors: Furuhashi
authors: Taiki
authors: T
authors: Fujimoto
authors: Hiroo
authors: H
authors: Suzuki
authors: Masaki
authors: M
authors: Harada
authors: Satoshi
authors: S
authors: Maruyama
authors: Rika
authors: R
authors: Tamiya
authors: Eri
authors: E
authors: Kamiya
authors: Mari
authors: M
authors: Okamoto
authors: Atsuyo
authors: A
authors: Tukada
authors: Mikako
authors: M
authors: Furuhashi
authors: Akihiko
authors: A
authors: Kato
mesh_terms: D000368:Aged; D002118:Calcium / Q000097:blood; D002626:Chemistry, Pharmaceutical; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D007811:Lanthanum / Q000008:administration & dosage* / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D015596:Nutrition Assessment; D010281:Parathyroid Hormone / Q000097:blood; D057240:Patient Preference; D010758:Phosphorus / Q000097:blood*; D006435:Renal Dialysis; D012189:Retrospective Studies; D012709:Serum Albumin / Q000187:drug effects; D013607:Tablets
chemical_list: D010281:Parathyroid Hormone; D012709:Serum Albumin; D013607:Tablets; D010758:Phosphorus; C119467:lanthanum carbonate; D007811:Lanthanum; D002118:Calcium
keywords: chewable tablets; granules; laboratory parameters; lanthanum carbonate; patient survey