title: In pursuit of the ideal antifungal agent for Candida infections: high-throughput screening of small molecules.
abstract: Candida infections have created a great burden on the public healthcare sector. The situation is worsened by recent epidemiological changes. Furthermore, the current arsenal of antifungal agents is limited and associated with undesirable drawbacks. Therefore, new antifungal agents that surpass the existing ones are urgently needed. High-throughput screening of small molecule libraries enables rapid hit identification and, possibly, increases hit rate. Moreover, the identified hits could be associated with unrecognized or multiple drug targets, which would provide novel insights into the biological processes of the pathogen. Hence, it is proposed that high-throughput screening of small molecules is particularly important in the pursuit of the ideal antifungal agents for Candida infections.
authors: Faculty of Dentistry, University of Hong Kong, Hong Kong.
authors: Sarah S W
authors: SSW
authors: Wong
authors: School of Dentistry, University of Queensland, Australia.
authors: Lakshman P
authors: LP
authors: Samaranayake
authors: Faculty of Dentistry, University of Hong Kong, Hong Kong; Oral Sciences, Faculty of Dentistry, National University of Singapore, Singapore. Electronic address: jaya@nus.edu.sg.
authors: Chaminda J
authors: CJ
authors: Seneviratne
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use; D002175:Candida; D002177:Candidiasis / Q000188:drug therapy; D055808:Drug Discovery; D025141:Drug Resistance, Fungal; D057166:High-Throughput Screening Assays; D006801:Humans; D054852:Small Molecule Libraries
chemical_list: D000935:Antifungal Agents; D054852:Small Molecule Libraries