title: New 6% hydroxyethyl starch 130/0.4 does not increase blood loss during major abdominal surgery - a randomized, controlled trial.
abstract: OBJECTIVE
  Ideal fluid management during surgery still poses a clinical dilemma gauging the benefits and adverse effects. This randomized controlled trial compared the tissue perfusion and coagulation profiles under clinically equivalent hydroxyethyl starch (HES 130/0.4) and lactated Ringer's solution (LR).
  
  
  METHODS
  Eighty-four patients undergoing major abdominal surgery were randomized to receive either HES or LR. Tissue perfusion parameters using heart rate, arterial blood pressure, central venous pressure, cardiac index, stroke volume index, and central venous oxygen saturation were measured at T0 (baseline), T1 (start of surgery), T2 (1 hour after start of surgery), and T3 (end of surgery). Coagulation parameters using thrombelastography (TEG) were measured at T0 (baseline), T4 (after 15 mL/kg fluid transfused), and T5 (24 hours after baseline).
  
  
  RESULTS
  The total amount of fluid administrated was 1547.9 ± 424.0 mL in HES group and 2303.1 ± 1033.7 mL in LR group (p < 0.001). The parameters of tissue perfusion and TEG did not differ significantly between groups at any time point except for a transient decrease in clot kinetic and clot strength at T4 for HES group. There was no significant difference in blood loss and consumption of blood products between the two fluids.
  
  
  CONCLUSIONS
  HES 130/0.4 is a more efficient intravascular volume expander to maintain tissue perfusion than conventional crystalloid. Transient hypocoagulability induced by HES 130/0.4 does not warrant excessive blood loss and blood transfusion.
authors: Department of Anesthesiology, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.
authors: Ming-Hui
authors: MH
authors: Hung
authors: Department of Anesthesiology, Fujian Provincial Hospital, Fuzhou, China.
authors: Conghua
authors: C
authors: Zou
authors: Department of Anesthesiology, National Taiwan University Hospital, Taipei, Taiwan.
authors: Feng-Sheng
authors: FS
authors: Lin
authors: Department of Anesthesiology, National Taiwan University Hospital, Taipei, Taiwan.
authors: Chen-Jung
authors: CJ
authors: Lin
authors: Department of Anesthesiology, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address: jkjchan@gmail.com.
authors: Kuang-Cheng
authors: KC
authors: Chan
authors: Department of Anesthesiology, Fujian Provincial Hospital, Fuzhou, China. Electronic address: sxd605@21cn.com.
authors: Yanqing
authors: Y
authors: Chen
mesh_terms: D000005:Abdomen / Q000601:surgery*; D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects*; D016063:Blood Loss, Surgical; D005260:Female; D005440:Fluid Therapy / Q000379:methods; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000008:administration & dosage*; D007552:Isotonic Solutions / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D010952:Plasma Substitutes / Q000008:administration & dosage*; D000077325:Ringer's Lactate; D013916:Thrombelastography
chemical_list: D006895:Hydroxyethyl Starch Derivatives; D007552:Isotonic Solutions; D010952:Plasma Substitutes; D000077325:Ringer's Lactate
keywords: abdominal surgery; blood coagulation; fluid therapy; hydroxyethyl starch; tissue perfusion