title: Ruthenium-catalyzed cyclization of anilides with substituted propiolates or acrylates: an efficient route to 2-quinolinones.
abstract: A Ru-catalyzed cyclization of anilides with propiolates or acrylates affording 2-quinolinones having diverse functional groups in good to excellent yields is described. Later, 2-quinolinones were converted into 3-halo-2-quinolinones and 2-chloroquinolines. The proposed mechanism was strongly supported by experimental evidence and deuterium labeling studies.
authors: Department of Chemistry, Indian Institute of Science Education and Research , Pune 411021, India.
authors: Rajendran
authors: R
authors: Manikandan
authors: Masilamani
authors: M
authors: Jeganmohan
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D000813:Anilides / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D006842:Hydrocarbons, Brominated / Q000138:chemical synthesis* / Q000737:chemistry; D006843:Hydrocarbons, Chlorinated; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D000179:Acrylates; D000813:Anilides; D006842:Hydrocarbons, Brominated; D006843:Hydrocarbons, Chlorinated; D011804:Quinolines; D015363:Quinolones; D012428:Ruthenium; C083774:2-chloroquinoline