title: Placental cytokine and chemokine profiles reflect pregnancy outcomes in women exposed to Plasmodium falciparum infection.
abstract: Pregnancy-associated malaria (PAM) can lead to severe complications for both mother and baby. Certain placental cytokine/chemokine profiles have been shown to reflect poor pregnancy outcomes, including maternal anemia and low birth weight. In intervillous plasma samples from 400 Beninese women living in an area where Plasmodium falciparum is endemic, we quantified 16 cytokines/chemokines. We assessed their profiles in groups with PAM, with maternal anemia, with preterm births, or with a low birth weight for gestational age. Repeated ultrasound measurements ensured that prematurity and low birth weight were highly accurate. Preliminary analyses revealed trends for lower cytokine/chemokine concentrations in placental plasma associated both with babies with low birth weight for gestational age and with P. falciparum infection during pregnancy, while, as a function of the latter, the concentration of gamma interferon (IFN-γ)-inducible protein 10 (IP-10) was higher. Multivariate analyses showed that (i) higher placental plasma interleukin-10 (IL-10) levels were associated with P. falciparum infections and (ii) independently of P. falciparum infections, lower concentrations of both IFN-γ and IL-5 were associated with low birth weight for gestational age. Our data further strengthen the idea that IL-10 and IP-10 could be useful diagnostic markers of P. falciparum infection during pregnancy. The concentrations of cytokines/chemokines in placental plasma may represent previously unrecognized markers of poor fetal growth.
authors: INSERM UMR_1134, Paris, France Université Paris Diderot, Sorbonne Paris Cité, UMR_S1134, Paris, France Institut National de la Transfusion Sanguine, Paris, France Laboratory of Excellence GR-Ex, Paris, France.
authors: Arnaud
authors: A
authors: Chêne
authors: Laboratory of Excellence GR-Ex, Paris, France Institut de Recherche pour le Développement, UMR_216, Mère et Enfant Face aux Infections Tropicales, Paris, France PRES Sorbonne Paris Cité, Faculté de Pharmacie, Paris, France.
authors: Valérie
authors: V
authors: Briand
authors: Centre d'Étude et de Recherche sur le Paludisme Associé à la Grossesse et à l'Enfance (CERPAGE), Faculté des Sciences de la Santé, Université d'Abomey-Calavi, Abomey-Calavi, Benin.
authors: Samad
authors: S
authors: Ibitokou
authors: INSERM UMR_1134, Paris, France Université Paris Diderot, Sorbonne Paris Cité, UMR_S1134, Paris, France Institut National de la Transfusion Sanguine, Paris, France Laboratory of Excellence GR-Ex, Paris, France.
authors: Sébastien
authors: S
authors: Dechavanne
authors: Centre d'Étude et de Recherche sur le Paludisme Associé à la Grossesse et à l'Enfance (CERPAGE), Faculté des Sciences de la Santé, Université d'Abomey-Calavi, Abomey-Calavi, Benin.
authors: Achille
authors: A
authors: Massougbodji
authors: Laboratory of Excellence GR-Ex, Paris, France Institut de Recherche pour le Développement, UMR_216, Mère et Enfant Face aux Infections Tropicales, Paris, France PRES Sorbonne Paris Cité, Faculté de Pharmacie, Paris, France.
authors: Philippe
authors: P
authors: Deloron
authors: Laboratory of Excellence GR-Ex, Paris, France Institut de Recherche pour le Développement, UMR_216, Mère et Enfant Face aux Infections Tropicales, Paris, France PRES Sorbonne Paris Cité, Faculté de Pharmacie, Paris, France.
authors: Adrian J F
authors: AJ
authors: Luty
authors: INSERM UMR_1134, Paris, France Université Paris Diderot, Sorbonne Paris Cité, UMR_S1134, Paris, France Institut National de la Transfusion Sanguine, Paris, France Laboratory of Excellence GR-Ex, Paris, France.
authors: Benoît
authors: B
authors: Gamain
authors: Laboratory of Excellence GR-Ex, Paris, France Institut de Recherche pour le Développement, UMR_216, Mère et Enfant Face aux Infections Tropicales, Paris, France PRES Sorbonne Paris Cité, Faculté de Pharmacie, Paris, France fievet@ird.fr.
authors: Nadine
authors: N
authors: Fievet
mesh_terms: D000328:Adult; D018925:Chemokines / Q000097:blood; D016207:Cytokines / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000276:immunology; D006801:Humans; D007371:Interferon-gamma / Q000097:blood / Q000276:immunology; D016753:Interleukin-10 / Q000097:blood / Q000276:immunology; D015848:Interleukin-5; D016778:Malaria, Falciparum / Q000097:blood* / Q000276:immunology* / Q000382:microbiology; D010920:Placenta / Q000276:immunology* / Q000382:microbiology; D010963:Plasmodium falciparum / Q000276:immunology*; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000097:blood / Q000276:immunology / Q000382:microbiology; D011256:Pregnancy Outcome
chemical_list: D018925:Chemokines; D016207:Cytokines; D015848:Interleukin-5; D016753:Interleukin-10; D007371:Interferon-gamma