title: Prognostic factors for acute kidney injury following transarterial chemoembolization in patients with hepatocellular carcinoma.
abstract: OBJECTIVE
  Transarterial chemoembolization (TACE) is an effective treatment for patients with unresectable hepatocellular carcinoma (HCC). However, acute kidney injury (AKI) is a severe complication that commonly occurs in patients undergo TACE. In this study, we aim to investigate the incidence and risk factors associated with AKI in HCC patients received TACE treatment.
  
  
  METHODS
  This study enrolled 380 HCC patients who received a total of 453 TACE treatments. The incidence, clinical outcomes and risk factors of AKI were examined.
  
  
  RESULTS
  The incidence of post-TACE AKI was 9.05% (41/453). Of these, 3 patients (7.3%) progressed to chronic kidney failure while 7 patients (17.1%) died within 1 month of TACE. The Child-Pugh score (OR=3.784, 95% CI 1.899-7.542, p=0.000), pre-operative serum uric acid (OR=1.450, 95% CI 1.202-1.750, p=0.000), and proteinuria (OR=2.393, 95% CI 1.139-5.031, p=0.021) were independent risk factors for the development of post-TACE AKI.
  
  
  CONCLUSIONS
  AKI is a common complication in HCC patients received TACE. The Child-Pugh score, preoperative serum uric acid and proteinuria may be used to predict the risk of post-TACE AKI in HCC patients undergo TACE.
authors: Department of Interventional Radiology, The Anhui Provincial Hospital Hefei, Anhui, China.
authors: Chunze
authors: C
authors: Zhou
authors: Department of Nephrology, The Second Affiliated Hospital of The Medical University of Anhui China.
authors: Ruifeng
authors: R
authors: Wang
authors: Department of Interventional Radiology, The Anhui Provincial Hospital Hefei, Anhui, China.
authors: Yikun
authors: Y
authors: Ding
authors: Center of Interventional Therapy, The Second Affiliated Hospital of The Medical University of Anhui China.
authors: Linan
authors: L
authors: Du
authors: Department of Interventional Radiology, The Anhui Provincial Hospital Hefei, Anhui, China.
authors: Changlong
authors: C
authors: Hou
authors: Department of Interventional Radiology, The Anhui Provincial Hospital Hefei, Anhui, China.
authors: Dong
authors: D
authors: Lu
authors: Department of Nephrology, The Second Affiliated Hospital of The Medical University of Anhui China.
authors: Li
authors: L
authors: Hao
authors: Department of Interventional Radiology, The Anhui Provincial Hospital Hefei, Anhui, China.
authors: Weifu
authors: W
authors: Lv
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality; D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000401:mortality / Q000628:therapy*; D016461:Chemoembolization, Therapeutic / Q000009:adverse effects* / Q000401:mortality; D002681:China / Q000453:epidemiology; D018450:Disease Progression; D005260:Female; D006801:Humans; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000209:etiology; D008113:Liver Neoplasms / Q000097:blood / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000150:complications; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D014527:Uric Acid / Q000097:blood
chemical_list: D014527:Uric Acid
keywords: AKI; HCC; TACE; kidney failure; liver cancer