title: A study of cervical intraepithelial neoplasia in pregnancy.
abstract: OBJECTIVE
  To find the incidence of human papillomavirus (HPV) infection and cervical intraepithelial neoplasia (CIN) in pregnant women and compare Pap smear with the HPV DNA test in detecting HPV infection.
  
  
  METHODS
  Hundred antenatal women, irrespective of gestational age, were enrolled as subjects in this prospective pilot study for blood investigations, wet mount examination of cervical discharge, Pap smear, and high-risk HPV DNA detection of cervical scrape by PCR. Women showing abnormality in Pap smear and/or those who were high-risk HPV DNA positive were subjected to colposcopy.
  
  
  RESULTS
  The incidence of HPV-positive pregnant women was 18 %. Koilocytosis on Pap smear was observed in six women. Three high-risk HPV DNA-positive women showed changes consistent with CIN 1 on colposcopy.
  
  
  CONCLUSIONS
  The HPV DNA test is the most sensitive and reliable in detecting HPV infection as compared to Pap smear, but considering the cost of PCR, Pap smear screening of all antenatal women was recommended.
authors: Subharti Medical College, Meerut, India.
authors: Esha
authors: E
authors: Khanuja
authors: Subharti Medical College, Meerut, India.
authors: U K
authors: UK
authors: Ghosh
authors: Subharti Medical College, Meerut, India.
authors: Parul
authors: P
authors: Garg
authors: Subharti Medical College, Meerut, India.
authors: Geetika
authors: G
authors: Tomar
authors: Subharti Medical College, Meerut, India.
authors: Molly
authors: M
authors: Madan
authors: Subharti Medical College, Meerut, India.
authors: Rani
authors: R
authors: Bansal
keywords: Cervical intraepithelial neoplasia; Colposcopy; HPV DNA; Human papillomavirus; Pap smear