title: Copper-catalyzed aerobic oxidative amination of sp3 C-H bonds: efficient synthesis of 2-hetarylquinazolin-4(3H)-ones.
abstract: An efficient synthesis of 2-hetarylquinazolin-4(3H)-ones via copper-catalyzed direct aerobic oxidative amination of sp(3)C-H bonds has been developed. This tandem oxidation-amination-cyclization transformation represents a straightforward protocol to prepare 2-hetaryl-substituted quinazolinones from easily available 2-aminobenzamides and (2-azaaryl)methanes.
authors: State Key Laboratory of Chemo/Biosensing and Chemo metrics, College of Chemistry and Chemical Engineering, Hunan University , Changsha 410082, China.
authors: Qiang
authors: Q
authors: Li
authors: Yao
authors: Y
authors: Huang
authors: Tieqiao
authors: T
authors: Chen
authors: Yongbo
authors: Y
authors: Zhou
authors: Qing
authors: Q
authors: Xu
authors: Shuang-Feng
authors: SF
authors: Yin
authors: Li-Biao
authors: LB
authors: Han
mesh_terms: D000586:Amination; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D006575:Heterocyclic Compounds, 3-Ring / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D052999:Quinazolinones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D006575:Heterocyclic Compounds, 3-Ring; D052999:Quinazolinones; D003300:Copper