title: Opinions, hopes and concerns regarding pharmacogenomics: a comparison of healthy individuals, heart failure patients and heart transplant recipients.
abstract: It is not yet known whether healthy individuals and patients with a chronic disease have similar attitudes towards pharmacogenomics. Thus we conducted a survey of 175 healthy volunteers, 175 heart failure (HF) patients and 100 heart transplant recipients to compare their opinions on this subject. Most participants (>90%) stated that they would accept pharmacogenomic testing and expressed high hopes regarding its potential applications. Overall, interest for pharmacogenomics was shared equally among the three groups. In contrast, after adjusting for age, gender, education and income, healthy individuals were more likely to voice concerns about potential employment (P=0.008 vs HF, odds ratio (OR)=2.93, confidence interval (CI)=1.33-6.47; P=0.010 vs Transplant, OR=2.46, CI=1.24-4.90) and insurance discrimination (P=0.001 vs HF, OR=5.58, CI=2.01-15.48; P<0.001 vs Transplant, OR=4.98, CI=2.03-12.21) and were possibly more worried by confidentiality issues. These findings highlight the need for strict legislation and proper educational strategies directed at the general population to facilitate the clinical implementation of pharmacogenomics.
authors: 1] Research Centre, Montreal Heart Institute, Montreal, Quebec, Canada [2] Faculty of Pharmacy, Université de Montréal, Montreal, Quebec, Canada.
authors: K
authors: K
authors: Lachance
authors: 1] Research Centre, Montreal Heart Institute, Montreal, Quebec, Canada [2] Faculty of Pharmacy, Université de Montréal, Montreal, Quebec, Canada.
authors: S
authors: S
authors: Korol
authors: 1] Research Centre, Montreal Heart Institute, Montreal, Quebec, Canada [2] Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
authors: E
authors: E
authors: O'Meara
authors: 1] Research Centre, Montreal Heart Institute, Montreal, Quebec, Canada [2] Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
authors: A
authors: A
authors: Ducharme
authors: 1] Research Centre, Montreal Heart Institute, Montreal, Quebec, Canada [2] Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
authors: N
authors: N
authors: Racine
authors: 1] Research Centre, Montreal Heart Institute, Montreal, Quebec, Canada [2] Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
authors: M
authors: M
authors: Liszkowski
authors: 1] Research Centre, Montreal Heart Institute, Montreal, Quebec, Canada [2] Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
authors: J L
authors: JL
authors: Rouleau
authors: 1] Research Centre, Montreal Heart Institute, Montreal, Quebec, Canada [2] Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
authors: G B
authors: GB
authors: Pelletier
authors: 1] Research Centre, Montreal Heart Institute, Montreal, Quebec, Canada [2] Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
authors: M
authors: M
authors: Carrier
authors: 1] Research Centre, Montreal Heart Institute, Montreal, Quebec, Canada [2] Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
authors: M
authors: M
authors: White
authors: 1] Research Centre, Montreal Heart Institute, Montreal, Quebec, Canada [2] Faculty of Pharmacy, Université de Montréal, Montreal, Quebec, Canada.
authors: S
authors: S
authors: de Denus
mesh_terms: D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D003469:Culture; D005260:Female; D006333:Heart Failure / Q000235:genetics / Q000523:psychology* / Q000601:surgery; D016027:Heart Transplantation / Q000523:psychology*; D065026:Hope; D006801:Humans; D008297:Male; D008875:Middle Aged; D010597:Pharmacogenetics / Q000639:trends; D066027:Transplant Recipients / Q000523:psychology*