title: Smoking, family history of cancer, and diabetes mellitus are associated with the age of onset of pancreatic cancer in Japanese patients.
abstract: OBJECTIVE
  The aim of this study was to examine the association of risk factors including diabetes mellitus (DM) with the age of onset in Japanese pancreatic cancer (PC) patients.
  
  
  METHODS
  We retrospectively reviewed 688 PC patients diagnosed at our institute. We analyzed the association between the age of onset of PC and the following variables: sex, smoking, alcohol, DM, and a family history of cancer especially PC.
  
  
  RESULTS
  The mean age of PC diagnosis was 67.6 years. The onset of PC occurred earlier in current smokers (63.6 years old, P < 0.001) compared with past smokers (69.5 years old) and never smokers (68.6 years old). Patients with long-standing DM (>2 years) were older (70.5 years, P < 0.001) when diagnosed with PC than patients with new-onset DM (within 2 years) (66.9 years old) and patients without DM (66.7 years old). In the multivariate analysis, current smokers and a family history of cancer other than PC were associated with earlier onset. Conversely, long-standing DM was associated with later onset.
  
  
  CONCLUSIONS
  In Japanese PC patients, current smokers and a family history of cancer other than PC were associated with a younger age of onset. Conversely, long-standing DM was associated with a later onset.
authors: From the Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
authors: Suguru
authors: S
authors: Mizuno
authors: Yousuke
authors: Y
authors: Nakai
authors: Hiroyuki
authors: H
authors: Isayama
authors: Shuhei
authors: S
authors: Kawahata
authors: Tomotaka
authors: T
authors: Saito
authors: Kaoru
authors: K
authors: Takagi
authors: Takeo
authors: T
authors: Watanabe
authors: Rie
authors: R
authors: Uchino
authors: Tsuyoshi
authors: T
authors: Hamada
authors: Koji
authors: K
authors: Miyabayashi
authors: Hirofumi
authors: H
authors: Kogure
authors: Takashi
authors: T
authors: Sasaki
authors: Natsuyo
authors: N
authors: Yamamoto
authors: Naoki
authors: N
authors: Sasahira
authors: Kenji
authors: K
authors: Hirano
authors: Takeshi
authors: T
authors: Tsujino
authors: Hideaki
authors: H
authors: Ijichi
authors: Keisuke
authors: K
authors: Tateishi
authors: Minoru
authors: M
authors: Tada
authors: Kazuhiko
authors: K
authors: Koike
mesh_terms: D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000453:epidemiology; D015992:Body Mass Index; D003920:Diabetes Mellitus / Q000097:blood / Q000188:drug therapy / Q000453:epidemiology*; D005192:Family Health; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology; D009765:Obesity / Q000453:epidemiology; D010190:Pancreatic Neoplasms / Q000453:epidemiology* / Q000235:genetics; D012189:Retrospective Studies; D012907:Smoking / Q000453:epidemiology*
chemical_list: D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents