title: Synthesis, characterization, and antioxidant properties of novel inulin derivatives with amino-pyridine group.
abstract: A series of novel inulin derivatives were synthesized via reaction of chloracetyl inulin (CAIL) with amino-pyridines, including 2-(2-amino-pyridyl)acetyl inulin chloride (2APAIL), 2-(3-amino-pyridyl)acetyl inulin chloride (3APAIL), 2-(4-amino-pyridyl)acetyl inulin chloride (4APAIL), 2-(2,3-diamino-pyridyl)acetyl inulin chloride (2,3DAPAIL), and 2-(3,4-diamino-pyridyl)acetyl inulin (3,4DAPAIL). The antioxidant property of the products and 2-pyridylacetyl inulin chloride (PAIL) against hydroxyl radicals (·OH), superoxide radicals (O2·), and DPPH radicals (DPPH·) were evaluated in vitro, respectively. Results showed that 4APAIL and 3,4DAPAIL exhibited remarkable improvement on scavenging ·OH and DPPH·, which can scavenge the radical of OH completely at 0.4 mg/mL. Besides, the scavenging activity of 2,3DAPAIL to O2· was excellent among all of the tested samples, reaching 85% at 1.6 mg/mL. These data indicate that all of the inulin derivatives have better antioxidant activities than inulin, and the scavenging effect indices are affected by the number and position of the amino group on pyridine grafted to the inulin derivatives.
authors: Key Laboratory of Coastal Biology and Bioresource Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China; University of Chinese Academy of Sciences, Beijing 100049, China.
authors: Yunxia
authors: Y
authors: Hu
authors: Laboratory of Environmental Monitoring, School of Tropical and Laboratory Medicine, Hainan Medical College, Haikou 571199, China.
authors: Jun
authors: J
authors: Zhang
authors: Laboratory of Environmental Monitoring, School of Tropical and Laboratory Medicine, Hainan Medical College, Haikou 571199, China.
authors: Chunwei
authors: C
authors: Yu
authors: Key Laboratory of Coastal Biology and Bioresource Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
authors: Qing
authors: Q
authors: Li
authors: Key Laboratory of Coastal Biology and Bioresource Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
authors: Fang
authors: F
authors: Dong
authors: Key Laboratory of Coastal Biology and Bioresource Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
authors: Gang
authors: G
authors: Wang
authors: Key Laboratory of Coastal Biology and Bioresource Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China. Electronic address: zhanyongguo@hotmail.com.
authors: Zhanyong
authors: Z
authors: Guo
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D007444:Inulin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013481:Superoxides / Q000037:antagonists & inhibitors
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D011725:Pyridines; D013481:Superoxides; D007444:Inulin; C023666:pyridine
keywords: Amino-pyridines; Antioxidant properties; Inulin derivatives