title: Protein Fractions from Korean Mistletoe (Viscum Album coloratum) Extract Induce Insulin Secretion from Pancreatic Beta Cells.
abstract: Mistletoe (Viscum Album coloratum) has been known as a medicinal plant in European and Asian countries. Recent data show that biological activity of mistletoe alleviates hypertension, heart disease, renal failure, and cancer development. In this study, we report the antidiabetic effect of Korean mistletoe extract (KME). KME treatments enhanced the insulin secretion from the pancreatic β -cell without any effects of cytotoxicity. PDX-1 and beta2/neuroD known as transcription factors that regulate the expression of insulin gene were upregulated by treatment of the KME protein fractions isolated by ion-exchange chromatography after ammonium sulfate precipitation. Furthermore, these KME protein fractions significantly lowered the blood glucose level and the volume of drinking water in alloxan induced hyperglycemic mice. Taken together with the findings, it provides new insight that KME might be served as a useful source for the development of medicinal reagent to reduce blood glucose level of type I diabetic patients.
authors: School of Life Sciences, Handong Global University, Pohang, Gyungbuk 791-708, Republic of Korea ; Department of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.
authors: Ki-Wook
authors: 0000-0001-7520-0216
authors: KW
authors: Kim
authors: School of Life Sciences, Handong Global University, Pohang, Gyungbuk 791-708, Republic of Korea ; Department of Biological Chemistry, The Weizmann Institute of Science, 76100 Rehovot, Israel.
authors: Seung-Hoon
authors: 0000-0002-6880-8861
authors: SH
authors: Yang
authors: School of Life Sciences, Handong Global University, Pohang, Gyungbuk 791-708, Republic of Korea.
authors: Jong-Bae
authors: JB
authors: Kim