title: Noninvasive Nitric Oxide Therapy in Right Ventricular Systolic Dysfunction Following Arterial Switch Procedure.
abstract: Right ventricular dysfunction is uncommon following surgical repair of dextrotransposition of great arteries (d-TGA) by the arterial switch procedure. Inhaled nitric oxide (iNO) is a specific pulmonary vasolidator that has proven successful in treating pulmonary hypertension when delivered via endotracheal tube. We present a five-month-old infant with d-TGA and ventricular septal defect (VSD) who developed pulmonary hypertensive crisis, causing severe right ventricular dysfunction with hemodynamic deterioration at day 6 postsurgical repair by VSD closure and arterial switch. He was successfully treated with iNO via nonrebreather face mask avoiding endotracheal reintubation. This modality should be considered in the management of such infants.
authors: American University of Beirut Medical Center, Department of Pediatrics and Adolescent Medicine, Beirut, Lebanon.
authors: Lama
authors: L
authors: Charafeddine
authors: American University of Beirut Medical Center, Department of Pediatrics and Adolescent Medicine, Beirut, Lebanon.
authors: Mariam
authors: M
authors: Arabi
authors: American University of Beirut Medical Center, Department of Pediatrics and Adolescent Medicine, Beirut, Lebanon.
authors: Kawsar
authors: K
authors: Alamiddine
authors: American University of Beirut Medical Center, Department of Pediatrics and Adolescent Medicine, Beirut, Lebanon.
authors: Mohammad Issam
authors: MI
authors: Khatib
authors: American University of Beirut Medical Center, Department of Pediatrics and Adolescent Medicine, Beirut, Lebanon.
authors: Fadi
authors: F
authors: Bitar
authors: King Faisal Specialist Hospital and Research Center, Heart Center, Riyadh, Saudi Arabia alhalees@kfshrc.edu.sa.
authors: Zohair Al
authors: ZA
authors: Halees
mesh_terms: D000280:Administration, Inhalation; D000069278:Arterial Switch Operation; D006439:Hemodynamics; D006801:Humans; D007223:Infant; D008297:Male; D009569:Nitric Oxide / Q000008:administration & dosage*; D014188:Transposition of Great Vessels / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D018497:Ventricular Dysfunction, Right / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*
chemical_list: D009569:Nitric Oxide
keywords: arterial switch operation; hypertension; inhaled nitric oxide; transposition of great arteries