title: Dynamics of inflammation resolution and symptom recovery during AECOPD treatment.
abstract: The association between increases in both systemic and airway inflammation and acute exacerbation of COPD (AECOPD) has been reported by many studies. However, relatively little is known about the dynamics of inflammation resolution and their correlations with the improvement of clinical indices during treatment. In this study, a total of 93 consecutively hospitalized patients with AECOPD were recruited. Sputum and serum inflammatory markers were measured on the day of admission before treatment (day 0), day 4, 7 and 14 during treatment as well as 8 weeks after discharge. Clinical indices (lung function, dyspnea and COPD assessment test (CAT) scores) were also measured at those time points. By day 4, all airway inflammatory measures rapidly decreased and returned to baseline level. Notably, lung function and dyspnea improved to the baseline level by day 4 as well, consistent with the resolution of respiratory inflammation. However, despite the significant decrease by day 4, systemic inflammation did not reach baseline until day 14, concordant with the decrease in CAT score. In summary, we observed a time lag between the resolution of systemic and airway inflammation, which were correlated with the improvements of different clinical indices.
authors: Department of Respiratory Medicine, Peking University Third Hospital, Beijing, China.
authors: Chun
authors: C
authors: Chang
authors: Department of Emergency Medicine, Peking University Third Hospital, Beijing, China.
authors: Zhiguo
authors: Z
authors: Guo
authors: Department of Respiratory Medicine, Peking University Third Hospital, Beijing, China.
authors: Ning
authors: N
authors: Shen
authors: Department of Respiratory Medicine, Peking University Third Hospital, Beijing, China.
authors: Bei
authors: B
authors: He
authors: Department of Respiratory Medicine, Peking University Third Hospital, Beijing, China.
authors: Wanzhen
authors: W
authors: Yao
authors: Department of Respiratory Medicine, Peking University Third Hospital, Beijing, China.
authors: Hong
authors: H
authors: Zhu
authors: Department of Pediatrics and Communicable Disease, University of Michigan, Ann Arbor, Michigan, United States of America.
authors: Jiangchao
authors: J
authors: Zhao
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy*; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy*; D020127:Recovery of Function; D012720:Severity of Illness Index; D016896:Treatment Outcome