title: Comparison of two differently processed acellular dermal matrix products for root coverage procedures: a prospective, randomized multicenter study.
abstract: BACKGROUND
  The purpose of this multicenter randomly controlled clinical trial was to compare two acellular dermal matrix (ADM) materials produced by different processing techniques, freeze-dried (FDADM) and solvent-dehydrated (SDADM) ADM, in their ability to correct Miller Class I and II recession defects.
  
  
  METHODS
  Eighty individuals from four study centers, each with a single maxillary anterior Miller Class I or II recession defect were enrolled. Participants were randomly assigned and treated with coronally advanced flap (CAF) + FDADM (n = 42) or CAF + SDADM (n = 38). Gingival thickness, recession depth, recession width, probing depth (PD), clinical attachment level, gingival index, plaque index, patient discomfort, and wound healing index were recorded before surgery (day 0), immediately after surgery (day 1), and 2, 4, 12, 24, and 52 weeks postoperatively. The Student t test, paired t test, and Kruskal-Wallis one-way ANOVA were used to analyze the data.
  
  
  RESULTS
  When evaluating the clinical parameters after 1 year, both groups showed significant (P <0.05) improvement for most of the parameters evaluated when compared to baseline (day 0). For example, percentage of root coverage was 77.21% ± 29.10% for CAF + FDADM and 71.01% ± 32.87% for CAF + SDADM. Conversely, no significant differences were observed between the two materials for any clinical parameter tested or for patient satisfaction except PD on the mesial side of the defects (P = 0.03).
  
  
  CONCLUSIONS
  Both FDADM and SDADM can be used successfully to correct Miller Class I or II recession defects. There were no statistically significant differences between groups for any of the clinical parameters tested.
authors: Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI.
authors: Hom-Lay
authors: HL
authors: Wang
authors: Georgios E
authors: GE
authors: Romanos
authors: Nicolaas C
authors: NC
authors: Geurs
authors: Andrew
authors: A
authors: Sullivan
authors: Fernando
authors: F
authors: Suárez-López Del Amo
authors: Robert M
authors: RM
authors: Eber
mesh_terms: D062088:Acellular Dermis / Q000145:classification; D000096:Acetone / Q000737:chemistry; D000328:Adult; D000368:Aged; D003774:Dental Plaque Index; D003890:Desiccation; D005260:Female; D005500:Follow-Up Studies; D005612:Freeze Drying; D005881:Gingiva / Q000473:pathology; D005889:Gingival Recession / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000209:etiology; D017060:Patient Satisfaction; D017622:Periodontal Attachment Loss / Q000145:classification; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000145:classification; D011446:Prospective Studies; D012997:Solvents / Q000737:chemistry; D013524:Surgical Flaps / Q000601:surgery; D014021:Tissue Preservation / Q000379:methods; D014092:Tooth Root / Q000601:surgery*; D055815:Young Adult
chemical_list: D012997:Solvents; D000096:Acetone
keywords: Acellular dermis; dental; esthetics; gingival recession; surgery, plastic; treatment outcome