title: Anti-rheumatic potential of ethyl 2-(2-cyano-3-mercapto-3-(phenylamino) acrylamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate and its Co(II), Cu(II) and Zn(II) complexes.
abstract: Ethyl 2-(2-cyano-3-mercapto-3-(phenylamino)acrylamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate [THBTD] and its [Co(THBTD]-H)Ac], [Cu(THBTD]-H)Ac]H2O and [Zn(THBTD)-H)Ac] complexes have been synthesized via the reaction of thiocarbamoyl derivatives with metal ions namely; Co(II), Cu(II) and Zn(II) acetate, respectively. The newly synthesized complexes were characterized by elemental analysis, spectral analysis (UV-Vis, IR, (1)H NMR and EPR), conductance, thermal analysis and magnetic moments. The in vivo collagen-adjuvant arthritis model in rats revealed significant antioxidant, analgesic and anti-rheumatic effects for [THBTD] and its copper complex.
authors: Chemistry Department, Faculty of Science and Arts, Ulla, Taibah University, Saudi Arabia; Clinical Pharmacology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt. Electronic address: youserysherif@gmail.com.
authors: Yousery E
authors: YE
authors: Sherif
authors: Chemistry Department, Faculty of Science, Port-Said University, Port-Said, Egypt.
authors: Nasser M
authors: NM
authors: Hosny
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D001169:Arthritis, Experimental / Q000188:drug therapy; D002264:Carboxylic Acids / Q000737:chemistry*; D003035:Cobalt / Q000737:chemistry; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D003300:Copper / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D012213:Rheumatic Fever / Q000188:drug therapy*; D013696:Temperature; D013876:Thiophenes / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D002264:Carboxylic Acids; D056831:Coordination Complexes; D013876:Thiophenes; C000596335:ethyl 2-(2-cyano-3-mercapto-3-(phenylamino)acrylamido)-4,5,6,7-tetrahydrobenzo(b)thiophene-3-carboxylate; D003035:Cobalt; D003300:Copper; D015032:Zinc
keywords: Anti rheumatic; Cu(II) and Zn(II) complexes; Thiocarbamyl