title: Epilepsy, diabetes mellitus and accidental injury at work.
abstract: OBJECTIVE
  To assess the contribution of epilepsy and diabetes to occupational injury.
  
  
  METHODS
  The Clinical Practice Research Datalink logs primary care data for 6% of the British population, coding all consultations and treatments. Using this, we conducted a population-based case-control study, identifying patients aged 16-64 years, who had consulted over two decades for workplace injury, plus matched controls. By conditional logistic regression, we assessed risks for diabetes and epilepsy overall, several diabetic complications and indices of poor control, occurrence of status epilepticus and treatment with hypoglycaemic and anti-epileptic agents.
  
  
  RESULTS
  We identified 1348 injury cases and 6652 matched controls. A total of 160 subjects (2%) had previous epilepsy, including 29 injury cases, whereas 199 (2.5%) had diabetes, including 77 with eye involvement and 52 with a record of poor control. Odds ratios (ORs) for occupational injury were close to unity, both in those with epilepsy (1.07) and diabetes (0.98) and in those prescribed anti-epileptic or hypoglycaemic treatments in the previous year (0.87-1.16). We found no evidence of any injury arising directly from a seizure and no one had consulted about their epilepsy within 100 days before their injury consultation. Two cases and six controls had suffered status epilepticus (OR versus never had epilepsy 1.61). Risks were somewhat higher for certain diabetic complications (OR 1.44), although lower among those with eye involvement (OR 0.70) or poor diabetic control (OR 0.50). No associations were statistically significant.
  
  
  CONCLUSIONS
  No evidence was found that diabetes or epilepsy are important contributors to workplace injury in Britain.
authors: MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK. ktp@mrc.soton.ac.uk.
authors: K T
authors: KT
authors: Palmer
authors: MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
authors: S
authors: S
authors: D'Angelo
authors: MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
authors: E C
authors: EC
authors: Harris
authors: MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
authors: C
authors: C
authors: Linaker
authors: MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
authors: D
authors: D
authors: Coggon
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000503:physiopathology; D004827:Epilepsy / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D060051:Occupational Injuries / Q000188:drug therapy / Q000209:etiology* / Q000517:prevention & control; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D007004:Hypoglycemic Agents
keywords: Accidents; diabetes; epilepsy; injury.