title: High-affinity IgE receptor gene polymorphism and allergic rhinitis in a Polish population.
abstract: BACKGROUND
  The high-affinity IgE receptor (FcɛRIβ subunit int 2) gene polymorphism is a candidate gene in atopic diseases and is associated with atopy. The aim of this biochemical study was to investigate the association of its intronic mutation and allergic rhinitis in a Polish population.
  
  
  METHODS
  100 atopic patients and 85 controls were included in the study. Polymerase chain reaction-based analysis for FcɛRIβ subunit int 2 gene polymorphism was used for genotyping and detection.
  
  
  RESULTS
  There was a difference in the frequencies of genotypes of FcɛRIβ subunit int 2 in allergic rhinitis patients and controls. The FcɛRIβ subunit int 2 gene polymorphism was found to be associated with allergic rhinitis in the Polish cohort.
  
  
  CONCLUSIONS
  The results indicate that genetic factors may play an important role in the allergic rhinitis development in the investigated group.
authors: Department of Alergology and Respiratory Rehabilitation, 2nd Chair of Otolaryngology, Medical University of Lodz, Poland.
authors: Barbara
authors: B
authors: Korzycka-Zaborowska
authors: Department of Otolaryngology and Laryngological Oncology, 2nd Chair of Otolaryngology, Medical University of Lodz, Poland.
authors: Hanna
authors: H
authors: Zielińska-Bliźniewska
authors: Department of Otolaryngology and Laryngological Oncology, 2nd Chair of Otolaryngology, Medical University of Lodz, Poland.
authors: Jarosław
authors: J
authors: Miłoński
authors: Department of Otolaryngology and Laryngological Oncology, 2nd Chair of Otolaryngology, Medical University of Lodz, Poland. Electronic address: jurek.olszewski@umed.lodz.pl.
authors: Jurek
authors: J
authors: Olszewski
mesh_terms: D000328:Adult; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D011044:Poland; D011110:Polymorphism, Genetic; D017455:Receptors, IgE / Q000235:genetics*; D012221:Rhinitis, Allergic, Perennial / Q000235:genetics*; D006255:Rhinitis, Allergic, Seasonal / Q000235:genetics*
chemical_list: C502447:MS4A2 protein, human; D017455:Receptors, IgE
keywords: Allergic rhinitis; Atopy; FcɛRIβ subunit int 2; Gene polymorphism