title: Targeting adenosine receptors to prevent inflammatory skin diseases.
abstract: Adenosine mediates its effects through activation of a family of four G-protein-coupled receptors, named A1 , A2A , A2B and A3 . This nucleoside plays an important role in immunity and inflammation, and the A2A adenosine receptor subtype has a key role in the inhibition of inflammatory processes besides promoting wound healing. In this issue of Experimental Dermatology, Arasa et al. show that the topical application of a selective A2A agonist, CGS 21680, to mouse skin reduced epidermal hyperplasia as well as skin inflammation, similarly to topical corticoids, without side effects like skin atrophy. Rigorously following up this work is important for the development of novel treatment strategies for chronic hyperproliferative inflammatory dermatoses, such as targeting the A2A adenosine receptor family.
authors: Department of Medical Science, Pharmacology Section, University of Ferrara, Ferrara, Italy.
authors: Stefania
authors: S
authors: Gessi
authors: Stefania
authors: S
authors: Merighi
authors: Pier Andrea
authors: PA
authors: Borea
mesh_terms: D000241:Adenosine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D058908:Adenosine A2 Receptor Agonists / Q000008:administration & dosage* / Q000627:therapeutic use*; D000818:Animals; D004817:Epidermis / Q000473:pathology*; D005260:Female; D007249:Inflammation / Q000517:prevention & control*; D010627:Phenethylamines / Q000008:administration & dosage* / Q000627:therapeutic use*; D012871:Skin Diseases / Q000517:prevention & control*
chemical_list: D058908:Adenosine A2 Receptor Agonists; D010627:Phenethylamines; C061282:2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine; D000241:Adenosine
keywords: adenosine receptors; epidermal; hyperplasia; inflammatory skin diseases; psoriasis