title: NAMI-A is highly cytotoxic toward leukaemia cell lines: evidence of inhibition of KCa 3.1 channels.
abstract: We report here that the established anticancer ruthenium(iii) complex NAMI-A induces potent and selective cytotoxic effects in a few leukaemia cell lines. These results sound very surprising after 20 years of intense studies on NAMI-A, commonly considered as a "non-cytotoxic" antimetastatic agent. In addition, evidence is given for selective inhibition of KCa 3.1 channels. The implications of these findings are discussed.
authors: Department of Experimental and Clinical Medicine, University of Florence, Viale GB Morgagni 50, 50134 Firenze, Italy. annarosa.arcangeli@unifi.it.
authors: Serena
authors: S
authors: Pillozzi
authors: Luca
authors: L
authors: Gasparoli
authors: Matteo
authors: M
authors: Stefanini
authors: Mirco
authors: M
authors: Ristori
authors: Massimo
authors: M
authors: D'Amico
authors: Enzo
authors: E
authors: Alessio
authors: Federica
authors: F
authors: Scaletti
authors: Andrea
authors: A
authors: Becchetti
authors: Annarosa
authors: A
authors: Arcangeli
authors: Luigi
authors: L
authors: Messori
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004121:Dimethyl Sulfoxide / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D051660:Intermediate-Conductance Calcium-Activated Potassium Channels / Q000037:antagonists & inhibitors*; D007938:Leukemia; D009942:Organometallic Compounds / Q000494:pharmacology*; D026902:Potassium Channel Blockers / Q000494:pharmacology*; D017975:Ruthenium Compounds
chemical_list: D000970:Antineoplastic Agents; D051660:Intermediate-Conductance Calcium-Activated Potassium Channels; C496923:KCNN4 protein, human; D009942:Organometallic Compounds; D026902:Potassium Channel Blockers; D017975:Ruthenium Compounds; C113661:imidazolium-bis(imidazole)dimethylsulfoxideimidazotetrachlororuthenate(III); D004121:Dimethyl Sulfoxide