title: Investigation on nanoparticle distribution for thermal ablation of a tumour subjected to nanoparticle assisted thermal therapy.
abstract: This study investigates the effect of the distribution of nanoparticles delivered to a skin tumour for the thermal ablation conditions attained during thermal therapy. Ultimate aim is to define a distribution of nanoparticles as well as a combination of other therapeutic parameters to attain thermal ablation temperatures (50-60 °C) within whole of the tumour region. Three different cases of nanoparticle distributions are analysed under controlled conditions for all other parameters viz. irradiation intensity and duration, and volume fraction of nanoparticles. Results show that distribution of nanoparticles into only the periphery of tumour resulted in desired thermal ablation temperature in whole of tumour. For the tumour size considered in this study, an irradiation intensity of 1.25 W/cm(2) for duration of 300 s and a nanoparticle volume fraction of 0.001% was optimal to attain a temperature of ≥53 °C within the whole tumour region. It is concluded that distribution of nanoparticles in peripheral region of tumour, along with a controlled combination of other parameters, seems favourable and provides a promising pathway for thermal ablation of a tumour subjected to nanoparticle assisted thermal therapy.
authors: School of Mechanical, Materials and Energy Engineering, Indian Institute of Technology Ropar, Rupnagar 140001, Punjab, India; Biomedical Instrumentation Division, CSIR-Central Scientific Instruments Organisation, Sector-30C, Chandigarh, India. Electronic address: ssoni@csio.res.in.
authors: Sanjeev
authors: S
authors: Soni
authors: School of Mechanical, Materials and Energy Engineering, Indian Institute of Technology Ropar, Rupnagar 140001, Punjab, India. Electronic address: himanshu.tyagi@iitrpr.ac.in.
authors: Himanshu
authors: H
authors: Tyagi
authors: School of Mechanical and Manufacturing Engineering, University of New South Wales, Kensington, Sydney 2032, Australia. Electronic address: rtaylor99@gmail.com.
authors: Robert A
authors: RA
authors: Taylor
authors: Biomedical Instrumentation Division, CSIR-Central Scientific Instruments Organisation, Sector-30C, Chandigarh, India. Electronic address: csioamod@yahoo.com.
authors: Amod
authors: A
authors: Kumar
mesh_terms: D004333:Drug Administration Routes; D006979:Hyperthermia, Induced; D008954:Models, Biological; D053758:Nanoparticles / Q000008:administration & dosage* / Q000627:therapeutic use; D009369:Neoplasms / Q000378:metabolism* / Q000628:therapy; D015203:Reproducibility of Results; D014018:Tissue Distribution
keywords: Cancer; Monte Carlo; Nanoparticle distribution; Nanoparticles; Thermal therapy; Tumour