title: Functional status at 18 months of age as a predictor of childhood disability after neonatal hypoxic-ischemic encephalopathy.
abstract: OBJECTIVE
  In children with neonatal hypoxic-ischemic encephalopathy (HIE), we examined the association between 18-month functional status by parental report and disability at 6-7 years.
  
  
  METHODS
  Prospective observational study involving participants in the NICHD randomized controlled trial of hypothermia for HIE. Parent questionnaires-Functional Status-II (FS-II), Impact on Family (IOF) and Family Resource Scale (FRS) at 18 months were correlated with 6- to 7-year developmental assessments. Disability at 6-7 years was defined as IQ < 70, gross motor functional classification scale level III-V, bilateral blindness, deafness, or epilepsy.
  
  
  RESULTS
  Rates of severe HIE (32 vs. 15%), public insurance (73% vs. 47%) and IOF scales were higher and mean (SD) FS-II independence (I) {54 (SD 35) vs. 98 (SD 8)} and general health (GH) {87 (SD 14) vs. 98 (SD 6)} scores were significantly lower in children with disability (n=37) at 6-7 years, compared to those (n=74) without disability. FS-II I scores were significantly associated with disability (OR 0.92; 95% CI 0.87-0.97; p=0.003). On path analysis, severe HIE, greater IOF and public insurance were associated with poorer 18-month FS-II I scores, which, in turn, were associated with disability at 6 to 7 years.
  
  
  CONCLUSIONS
  Poor independent functioning by parental report at 18 months in children with HIE was associated with childhood disability.
authors: Department of Pediatrics, Wayne State University, Detroit, MI, USA.
authors: Girija
authors: G
authors: Natarajan
authors: Seetha
authors: S
authors: Shankaran
authors: Athina
authors: A
authors: Pappas
authors: Carla
authors: C
authors: Bann
authors: Jon E
authors: JE
authors: Tyson
authors: Scott
authors: S
authors: McDonald
authors: Abhik
authors: A
authors: Das
authors: Susan
authors: S
authors: Hintz
authors: Betty
authors: B
authors: Vohr
authors: Rosemary
authors: R
authors: Higgins
mesh_terms: D000203:Activities of Daily Living; D000367:Age Factors; D001766:Blindness / Q000453:epidemiology / Q000209:etiology; D002648:Child; D003638:Deafness / Q000453:epidemiology / Q000209:etiology; D002658:Developmental Disabilities / Q000453:epidemiology* / Q000209:etiology* / Q000503:physiopathology / Q000523:psychology; D004827:Epilepsy / Q000453:epidemiology / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007036:Hypothermia, Induced; D020925:Hypoxia-Ischemia, Brain / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D007223:Infant; D016015:Logistic Models; D008297:Male; D009069:Movement Disorders / Q000453:epidemiology / Q000209:etiology; D010290:Parents; D011446:Prospective Studies; D011597:Psychomotor Performance; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires