title: Impact of metabolic syndrome on myocardial injury and clinical outcome after percutaneous coronary intervention.
abstract: OBJECTIVE
  This study tested the associations between metabolic syndrome, postprocedural myocardial injury, and clinical outcome after percutaneous coronary intervention.
  
  
  METHODS
  We evaluated 204 patients who fulfilled the study criteria and were scheduled for elective percutaneous coronary intervention. The patients were divided into a metabolic syndrome group and a control group according to the definition of metabolic syndrome. Creatine kinase-MB and troponin I levels were measured at baseline, at 8 h, and 24 h after the procedure, while clinical outcomes were followed up for 1 year.
  
  
  RESULTS
  The incidence of postprocedural myocardial injury was significantly higher in the metabolic syndrome group than in the control group as indicated by either blood creatine kinase-MB elevation (32.9 % vs. 17.2 %, p = 0.010) or troponin I elevation (34.2 % vs. 17.2 %, p = 0.006). Postprocedural peak values of creatine kinase-MB (5.724 ± 7.678 ng/ml vs. 3.097 ± 5.317 ng/ml, p < 0.001) and troponin I (0.066 ± 0.093 ng/ml vs. 0.038 ± 0.079 ng/ml, p < 0.001) were also significantly higher in the metabolic syndrome group than in the control group. On multiple regression analysis, metabolic syndrome was independently associated with troponin I elevation (odds ratio 2.24, 95 % confidence interval, CI, 1.04-4.80, p = 0.039). During the 1-year follow-up, cardiac events occurred in 28.9 % of patients with metabolic syndrome and 17.9 % of controls, and there was a trend toward increased adverse outcomes in the metabolic syndrome group (hazard ratio 1.67, 95 % CI 0.93-3.00, p = 0.071, log rank test).
  
  
  CONCLUSIONS
  The results of this study demonstrate that metabolic syndrome is associated with postprocedural myocardial injury and with increased cardiac events.
authors: Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, 100020, Beijing, China.
authors: J
authors: J
authors: Li
authors: S-J
authors: SJ
authors: Song
authors: J-P
authors: JP
authors: Xu
authors: X-Z
authors: XZ
authors: Zhao
authors: Z-W
authors: ZW
authors: Xu
authors: X-J
authors: XJ
authors: Sun
authors: L-F
authors: LF
authors: Wang
authors: X-C
authors: XC
authors: Yang
mesh_terms: D015984:Causality; D002681:China / Q000453:epidemiology; D015897:Comorbidity; D003324:Coronary Artery Disease / Q000453:epidemiology* / Q000601:surgery*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D017682:Myocardial Stunning / Q000453:epidemiology*; D062645:Percutaneous Coronary Intervention / Q000706:statistics & numerical data*; D011183:Postoperative Complications / Q000453:epidemiology*; D012307:Risk Factors; D016896:Treatment Outcome