title: Primary intracranial germ cell tumours: experience of a single South-East Asian institution.
abstract: Primary intracranial germ cell tumours (ICGCT) are a rare group of brain tumours arising predominantly in the paediatric and pre-adult population, accounting for up to 9.5% of paediatric brain tumours in East Asia. The National Cancer Centre Singapore (NCCS) is a tertiary referral centre for patients from all over South-East Asia. Our study aims to describe the characteristics of ICGCT patients in South-East Asia. Data on all patients with ICGCT who were seen at the Therapeutic Radiology Department of NCCS from 2000 to 2013 were collected retrospectively. Patient demographics, disease characteristics and treatment outcomes were analysed. Characteristics and survival of our patients were similar to other centres. Pure germinomas demonstrated 5 year overall survival (OS) and disease-free survival (DFS) rates of 89.2% (95% confidence interval [CI] 60.2-97.5) and 85.2% (95%CI 60.8-95.0) respectively. Secreting germinomas, non-germinomatous germ cell tumours and mixed germ cell tumours were evaluated together and demonstrated 5 year OS of 70.6% (95%CI 41.0-87.3) and DFS of 61.4% (95%CI 31.9-81.3). Patients ⩽ 12 years had marginally better 5 year OS than their older counterparts (81.0% [95%CI 49.5-93.9] versus 77.9% [95%CI 47.3-92.0], respectively). Patients who underwent extended field radiotherapy had longer OS and DFS than those who received local field irradiation. Treatment outcomes of our ICGCT patients are comparable with those in other Asian and Western centres. Extended field radiotherapy is a pivotal component of ICGCT treatment. Adding chemotherapy confers no extra survival benefit in treating germinomas. Treatment of mixed germ cell tumours and non-germinomatous germ cell tumours involves a multidisciplinary approach that varies for each histological subtype.
authors: Department of Medical Oncology, National Cancer Centre Singapore, 11 Hospital Dr, S169610, Singapore. Electronic address: aaronfoosongchuan@hotmail.com.
authors: Aaron S C
authors: AS
authors: Foo
authors: Department of Clinical Trials and Epidemiological Sciences, National Cancer Centre Singapore, Singapore.
authors: Cindy
authors: C
authors: Lim
authors: Department of Medical Oncology, National Cancer Centre Singapore, 11 Hospital Dr, S169610, Singapore.
authors: Dawn Q Q
authors: DQ
authors: Chong
authors: Therapeutic Radiology Department, National Cancer Centre Singapore, Singapore.
authors: Daniel Y H
authors: DY
authors: Tan
authors: Department of Medical Oncology, National Cancer Centre Singapore, 11 Hospital Dr, S169610, Singapore.
authors: Chee Kian
authors: CK
authors: Tham
mesh_terms: D000293:Adolescent; D000328:Adult; D001210:Asia, Southeastern / Q000453:epidemiology; D001932:Brain Neoplasms / Q000453:epidemiology* / Q000503:physiopathology / Q000628:therapy; D002648:Child; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000453:epidemiology* / Q000503:physiopathology / Q000628:therapy; D062606:Tertiary Care Centers; D016896:Treatment Outcome; D055815:Young Adult
keywords: Germ cell tumour; Intracranial; Mixed germ cell tumours; NGGCT