title: Correlation of midkine serum level with pro- and anti-inflamatory cytokines in multiple sclerosis.
abstract: BACKGROUND
  Midkine (MK) is a heparin-binding growth factor with promoting effects in inflammatory responses through enhancing leukocytes migration.
  
  
  OBJECTIVE
  To study the correlation between MK serum levels and concentration of inflammatory cytokines in Multiple Sclerosis (MS) patients.
  
  
  METHODS
  We evaluated the MK level and its relationship with inflammatory cytokines (IL-17 and IL-23) and anti-inflammatory ones (IL-10 and TGF-β) in multiple sclerosis (MS) patients. The serum concentrations of MK and cytokines were assessed by ELISA in 32 MS patients in comparison with 32 healthy subjects.
  
  
  RESULTS
  Our data showed that the MK concentration in MS patients is lower than healthy controls (341.15 ± 40.71 Pg/ml vs. 620.15 ± 98.61 Pg/ml, respectively, p=0.015). We also observed a significant decrease in IL-10, IL-23, and TGF-β cytokine levels in MS patients. There was a significant correlation between MK and IL-23 concentrations in our study (r = +0.829, p≤ 0.001).
  
  
  CONCLUSIONS
  These results confirm a role for MK in inflammatory reactions in MS.
authors: Department of Neurology and Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan 81745-319, Iran, e-mail: shaygannejad@med.mui.ac.ir.
authors: Vahid
authors: V
authors: Shaygannejad
authors: Saeed
authors: S
authors: Montazeri
authors: Azam
authors: A
authors: Jamshidian
authors: Soheil
authors: S
authors: Tahani
authors: Marjan
authors: M
authors: Gharagozloo
authors: Fereshteh
authors: F
authors: Ashtari
authors: Sahar
authors: S
authors: Vesal
authors: Seyed Javad
authors: SJ
authors: Hasheminia
authors: Leila
authors: L
authors: Dehghani
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D000078792:Midkine; D009103:Multiple Sclerosis / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D000078792:Midkine