title: N-Polybenzylated alicyclic 1,2-diamines: cytotoxicity and G1 phase arrest in cancer cell line.
abstract: Cytotoxicity in the μM range was observed in cancer cell lines treated with N,N,N',N'-tetrabenzyl-4,5-diamino-2-cyclopentenone. Cell cycle analysis on HeLa cells showed a clear G1 phase arrest. A preliminary SAR on structural analogs was performed in order to identify the pharmacophores.
authors: Dipartimento di Scienze del Farmaco, Università degli Studi del Piemonte Orientale "A. Avogadro", L.go Donegani 2, I-28100 , Novara NO, Italy.
authors: Antonio
authors: A
authors: Caldarelli
authors: Valeria
authors: V
authors: De Biasio
authors: Giovanni B
authors: GB
authors: Giovenzana
authors: Gianpiero
authors: G
authors: Mastronardo
authors: Roberto
authors: R
authors: Negri
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003959:Diamines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D059585:G1 Phase Cell Cycle Checkpoints / Q000187:drug effects*; D006801:Humans
chemical_list: D000970:Antineoplastic Agents; D003959:Diamines