title: Development and validation of the Mayo Clinic Bowel Prep Tolerability Questionnaire.
abstract: BACKGROUND
  Bowel cleansing is paramount for colonoscopy quality. Unfortunately, an adequate bowel preparation is often limited by side effects and/or patient's intolerance to bowel preparation solutions. Comparisons among different preparations are limited by the lack of validated instruments designed to assess patient's tolerability.
  
  
  OBJECTIVE
  To develop and validate a simple, comprehensive instrument to assess bowel preparation tolerability in patients undergoing colonoscopy.
  
  
  METHODS
  Development and validation by phases: Phase I (bibliographic search and questionnaire design); Phase II (assessment of content validity and modification of the questionnaire); Phase III (assessment of reproducibility, final validation, and definitive version of the questionnaire).
  
  
  RESULTS
  The initial draft of the questionnaire was generated based on a systematic literature review and feedback from a panel of consultants. Content validity was tested in a focus group of 25 patients undergoing colonoscopy. Patients' suggestions were reviewed by the research team and a second draft of the questionnaire was generated. Final validation and reproducibility were successfully tested (agreement: 86-100%, kappa: 0.77-1.00) in a convenience sample of 100 patients undergoing bowel preparation with different cleansing solutions.
  
  
  CONCLUSIONS
  The Mayo Clinic Bowel Prep Tolerability Questionnaire is a simple, comprehensive instrument suitable to evaluate the tolerability of various types of bowel preparations.
authors: Department of Gastroenterology, Mayo Clinic, Jacksonville, FL, USA.
authors: Mihir
authors: M
authors: Patel
authors: General Clinical Studies Unit, Mayo Clinic, Jacksonville, FL, USA.
authors: Estela
authors: E
authors: Staggs
authors: Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL, USA.
authors: Colleen S
authors: CS
authors: Thomas
authors: Department of Gastroenterology, Mayo Clinic, Jacksonville, FL, USA.
authors: Frank
authors: F
authors: Lukens
authors: Department of Gastroenterology, Mayo Clinic, Jacksonville, FL, USA.
authors: Michael
authors: M
authors: Wallace
authors: Department of Gastroenterology, Mayo Clinic, Jacksonville, FL, USA. Electronic address: almansa.cristina@mayo.edu.
authors: Cristina
authors: C
authors: Almansa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002400:Cathartics / Q000494:pharmacology*; D003113:Colonoscopy / Q000379:methods*; D015179:Colorectal Neoplasms / Q000175:diagnosis*; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012189:Retrospective Studies; D011795:Surveys and Questionnaires
chemical_list: D002400:Cathartics
keywords: Bowel preparation; Colonoscopy; Questionnaire; Tolerability