title: Cyclization and annulation reactions of nitrogen-substituted cyclopropanes and cyclobutanes.
abstract: Cyclization and annulation reactions initiated by ring-opening of small rings, especially cyclopropanes and cyclobutanes are now well-established in synthetic chemistry. Nevertheless, the potential of aminocyclopropanes and cyclobutanes, an important subclass for the synthesis of nitrogen-rich building blocks, has remained unexploited for a long time, despite important pioneering results. In the last decade, the situation has changed dramatically and new catalytic methods have emerged both for cyclization and annulation reactions. The purpose of this feature article is to present recent progress in this area, including our own work using donor-acceptor cyclopropanes and cyclobutanes.
authors: Laboratory of Catalysis and Organic Synthesis, Ecole Polytechnique Fédérale de Lausanne, EPFL SB ISIC LCSO, BCH 4306, 1015 Lausanne, Switzerland. jerome.waser@epfl.ch.
authors: F
authors: F
authors: de Nanteuil
authors: F
authors: F
authors: De Simone
authors: R
authors: R
authors: Frei
authors: F
authors: F
authors: Benfatti
authors: E
authors: E
authors: Serrano
authors: J
authors: J
authors: Waser
mesh_terms: D002384:Catalysis; D003500:Cyclization; D061565:Cycloaddition Reaction; D003503:Cyclobutanes / Q000737:chemistry*; D003521:Cyclopropanes / Q000737:chemistry*; D009584:Nitrogen / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D003503:Cyclobutanes; D003521:Cyclopropanes; D010165:Palladium; D009584:Nitrogen