title: Genetic association study with metabolic syndrome and metabolic-related traits in a cross-sectional sample and a 10-year longitudinal sample of chinese elderly population.
abstract: BACKGROUND
  The metabolic syndrome (MetS) has been known as partly heritable, while the number of genetic studies on MetS and metabolic-related traits among Chinese elderly was limited.
  
  
  METHODS
  A cross-sectional analysis was performed among 2 014 aged participants from September 2009 to June 2010 in Beijing, China. An additional longitudinal study was carried out among the same study population from 2001 to 2010. Biochemical profile and anthropometric parameters of all the participants were measured. The associations of 23 SNPs located within 17 candidate genes (MTHFR, PPARγ, LPL, INSIG, TCF7L2, FTO, KCNJ11, JAZF1, CDKN2A/B, ADIPOQ, WFS1, CDKAL1, IGF2BP2, KCNQ1, MTNR1B, IRS1, ACE) with overweight and obesity, diabetes, metabolic phenotypes, and MetS were examined in both studies.
  
  
  RESULTS
  In this Chinese elderly population, prevalence of overweight, central obesity, diabetes, dyslipidemia, hypertension, and MetS were 48.3%, 71.0%, 32.4%, 75.7%, 68.3% and 54.5%, respectively. In the cross-sectional analyses, no SNP was found to be associated with MetS. Genotype TT of SNP rs4402960 within the gene IGF2BP2 was associated with overweight (odds ratio (OR)  = 0.479, 95% confidence interval (CI): 0.316-0.724, p = 0.001) and genotype CA of SNP rs1801131 within the gene MTHFR was associated with hypertension (OR = 1.560, 95% CI: 1.194-2.240, p = 0.001). However, these associations were not observed in the longitudinal analyses.
  
  
  CONCLUSIONS
  The associations of SNP rs4402960 with overweight as well as the association of SNP rs1801131 with hypertension were found to be statistically significant. No SNP was identified to be associated with MetS in our study with statistical significance.
authors: Institute of Geriatrics, the General Hospital of the People's Liberation Army, Beijing, China; Beijing Key Lab of Aging and Geriatrics, the General Hospital of the People's Liberation Army, Beijing, China.
authors: Jinghui
authors: J
authors: Yang
authors: Institute of Geriatrics, the General Hospital of the People's Liberation Army, Beijing, China; Beijing Key Lab of Aging and Geriatrics, the General Hospital of the People's Liberation Army, Beijing, China.
authors: Jianwei
authors: J
authors: Liu
authors: Institute of Geriatrics, the General Hospital of the People's Liberation Army, Beijing, China; Beijing Key Lab of Aging and Geriatrics, the General Hospital of the People's Liberation Army, Beijing, China.
authors: Jing
authors: J
authors: Liu
authors: Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America.
authors: Wenyuan
authors: W
authors: Li
authors: Institute of Geriatrics, the General Hospital of the People's Liberation Army, Beijing, China; Department of Geriatric Cardiology, the General Hospital of the People's Liberation Army, Beijing, China.
authors: Xiaoying
authors: X
authors: Li
authors: Institute of Geriatrics, the General Hospital of the People's Liberation Army, Beijing, China; Beijing Key Lab of Aging and Geriatrics, the General Hospital of the People's Liberation Army, Beijing, China.
authors: Yao
authors: Y
authors: He
authors: Institute of Geriatrics, the General Hospital of the People's Liberation Army, Beijing, China; Beijing Key Lab of Aging and Geriatrics, the General Hospital of the People's Liberation Army, Beijing, China.
authors: Ling
authors: L
authors: Ye
mesh_terms: D000367:Age Factors; D000368:Aged; D044466:Asian People; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D019655:Quantitative Trait, Heritable; D012307:Risk Factors