title: Patients with myelodysplastic syndromes treated with azacitidine in clinical practice: the AVIDA registry.
abstract: The AVIDA registry evaluated azacitidine usage and effectiveness in unselected patients with myelodysplastic syndromes (MDS) in community practice. Treating physicians made all treatment decisions. Hematologic improvement (HI) and transfusion independence (TI) assessments used International Working Group (IWG) 2000 criteria. Enrolled were 421 patients with MDS (n = 228 International Prognostic Scoring System [IPSS] lower-risk, n = 106 higher-risk, 86 patients unclassified) from 105 US sites. Median follow-up was 7.6 months (range: 0.1-27.6). HI and red blood cell TI rates were similar regardless of administration route or dosing schedule. Safety and tolerability were consistent with previous reports. The AVIDA registry data support azacitidine effectiveness and safety in patients with lower- or higher-risk MDS treated in community practice.
authors: Division of Hematology, NorthShore University HealthSystem , Evanston, IL , USA.
authors: David L
authors: DL
authors: Grinblatt
authors: Mikkael A
authors: MA
authors: Sekeres
authors: Rami S
authors: RS
authors: Komrokji
authors: Arlene S
authors: AS
authors: Swern
authors: Kristen A
authors: KA
authors: Sullivan
authors: Mohit
authors: M
authors: Narang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects / Q000627:therapeutic use; D001374:Azacitidine / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000188:drug therapy*; D017063:Outcome Assessment, Health Care / Q000706:statistics & numerical data; D011446:Prospective Studies; D011788:Quality of Life; D012042:Registries / Q000706:statistics & numerical data*; D012307:Risk Factors; D014481:United States
chemical_list: D000964:Antimetabolites, Antineoplastic; D001374:Azacitidine
keywords: AVIDA; azacitidine; lower-risk MDS; myelodysplastic syndromes