title: Ethics of iPSC-based clinical research for age-related macular degeneration: patient-centered risk-benefit analysis.
abstract: The opportunity to undergo an induced pluripotent stem cell-based autologous transplant can strike patients as a chance for a cure from a debilitating condition with few options for respite. However, when clinical studies of this caliber present themselves, patients and researchers, each with their own set of motives, may find it difficult to take a balanced approach to evaluating them. We present a patient-centered risk-benefit analysis of the iPSC-based clinical research currently underway in Japan, including a survey of in vitro and in vivo tests that support this project, an in-depth discussion of risks, and further elucidation of considerations patients may wish to consider. The arguments presented will assist patients in undertaking a more informed decision-making process.
authors: Department of Internal Medicine, The Ohio State University College of Medicine, B054 Graves Hall, 333 W 10th Ave, Columbus, OH, 43210, USA, nakano.9@osu.edu.
authors: Mariko
authors: M
authors: Nakano-Okuno
authors: B Rashmi
authors: BR
authors: Borah
authors: Ichiro
authors: I
authors: Nakano
mesh_terms: D064592:Autografts / Q000601:surgery*; D035843:Biomedical Research / Q000379:methods; D003657:Decision Making; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000637:transplantation*; D007564:Japan; D008268:Macular Degeneration / Q000601:surgery*; D012306:Risk; D018570:Risk Assessment