title: TRPV2 in the development of experimental colitis.
abstract: Colitis is still a significant disease challenge in humans, but its underlying mechanism remains to be fully elucidated. The transient receptor potential vanilloid (TRPV) ion channel plays an important pathological role in host immunity, as deficiency of TRPV compromises host defence in vivo and in vitro. Using a DSS-induced colitis mouse model, the function of TRPV2 in the development of colitis was investigated, utilizing TRPV2(-/-) and Wt mice. Less severe colitis was observed in TRPV2(-/-) , compared to that of Wt mice, at the clinical, histopathological and immunohistochemical levels. Compared to Wt mice, reduced severity of colitis in TRPV2(-/-) mice may be due to less intestinal inflammation via reduced recruitment of macrophages. The TRPV2 pathway contributes to the development of colitis. These data provide useful information for potential therapeutic intervention in colitis patients.
authors: School of Life Science and Technology, TongJi University, Shanghai, China; Discipline of Pathology, Bosch Institute and School of Medical Sciences, University of Sydney, Sydney, NSW, Australia.
authors: C M
authors: CM
authors: Issa
authors: B D
authors: BD
authors: Hambly
authors: Y
authors: Y
authors: Wang
authors: S
authors: S
authors: Maleki
authors: W
authors: W
authors: Wang
authors: J
authors: J
authors: Fei
authors: S
authors: S
authors: Bao
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000235:genetics*; D003092:Colitis / Q000139:chemically induced / Q000235:genetics* / Q000473:pathology*; D016264:Dextran Sulfate / Q000494:pharmacology; D004195:Disease Models, Animal; D020397:Goblet Cells / Q000166:cytology / Q000276:immunology; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D007422:Intestines / Q000276:immunology / Q000473:pathology; D008262:Macrophage Activation / Q000235:genetics / Q000276:immunology; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D050916:TRPV Cation Channels / Q000235:genetics*
chemical_list: D015220:Calcium Channels; D050916:TRPV Cation Channels; C485717:Trpv2 protein, mouse; D016264:Dextran Sulfate