title: MiR-215/192 participates in gastric cancer progression.
abstract: BACKGROUND
  Growing evidence indicates that microRNAs (miRNAs) play critical roles in cancer progression. However, the role of miR-215 or miR-192 in gastric carcinogenesis remains unclear at this point.
  
  
  METHODS
  Quantitative real-time PCR analysis is used to detect the expression levels of miR-215 or -192. Matrigel invasion assay is used to explore the effects of miR-215 or -192 on gastric cancer cells invasion ability. Statistical analysis is carried out by SPSS 19.0 software.
  
  
  RESULTS
  MiR-215/192 is significantly up-regulated in gastric cancer tissues from gastrectomy. The up-regulation of miR-215 or -192 was related with the clinical characteristics of gastric cancer, such as lymph node metastasis. Inhibition of miR-215/192 significantly suppressed gastric cancer cell invasion. Statistical analysis indicated that the expression of miR-215 or -192 may be a potential candidate biomarker for gastric cancer prognosis.
  
  
  CONCLUSIONS
  These data suggest that frequently up-regulated miR-215/192 in gastric cancer may participate in gastric cancer progression.
authors: Department of Chemotherapy, Zhejiang Cancer Hospital, Hangzhou, 310022, China, xyj8288@hotmail.com.
authors: Y J
authors: YJ
authors: Xu
authors: Y
authors: Y
authors: Fan
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D063646:Carcinogenesis; D049109:Cell Proliferation; D003094:Collagen / Q000737:chemistry; D018450:Disease Progression; D004338:Drug Combinations; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007797:Laminin / Q000737:chemistry; D008207:Lymphatic Metastasis; D008297:Male; D035683:MicroRNAs / Q000378:metabolism*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D011509:Proteoglycans / Q000737:chemistry; D060888:Real-Time Polymerase Chain Reaction; D012984:Software; D013274:Stomach Neoplasms / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; D004338:Drug Combinations; D007797:Laminin; C546783:MIRN192 microRNA, human; C553667:MIRN215 microRNA, human; D035683:MicroRNAs; D011509:Proteoglycans; C059485:matrigel; D003094:Collagen