title: Changes in capsule and drug resistance of Pneumococci after introduction of PCV7, Japan, 2010-2013.
abstract: We aimed to clarify changes in serotypes and genotypes mediating β-lactam and macrolide resistance in Streptococcus pneumoniae isolates from Japanese children who had invasive pneumococcal disease (IPD) after the 7-valent pneumococcal conjugate vaccine (PCV7) was introduced into Japan; 341 participating general hospitals conducted IPD surveillance during April 2010-March 2013. A total of 300 pneumococcal isolates were collected in 2010, 146 in 2011, and 156 in 2012. The proportion of vaccine serotypes in infectious isolates decreased from 73.3% to 54.8% to 14.7% during the 3 years. Among vaccine serotype strains, genotypic penicillin-resistant S. pneumoniae strains also declined each year. Among nonvaccine serotype strains, 19A, 15A, 15B, 15C, and 24 increased in 2012. Increases were noted especially in genotypic penicillin-resistant S. pneumoniae isolates of serotypes 15A and 35B, as well as macrolide resistance mediated by the erm(B) gene in 15A, 15B, 15C, and 24.
authors: Naoko
authors: N
authors: Chiba
authors: Miyuki
authors: M
authors: Morozumi
authors: Michi
authors: M
authors: Shouji
authors: Takeaki
authors: T
authors: Wajima
authors: Satoshi
authors: S
authors: Iwata
authors: Kimiko
authors: K
authors: Ubukata
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial / Q000187:drug effects / Q000235:genetics* / Q000276:immunology; D005838:Genotype; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D007223:Infant; D007564:Japan; D018942:Macrolides / Q000627:therapeutic use; D010406:Penicillins / Q000627:therapeutic use; D011008:Pneumococcal Infections / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*; D022242:Pneumococcal Vaccines / Q000276:immunology*; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000187:drug effects / Q000235:genetics* / Q000276:immunology; D018440:beta-Lactam Resistance / Q000235:genetics* / Q000276:immunology
chemical_list: D000900:Anti-Bacterial Agents; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D018942:Macrolides; D010406:Penicillins; D022242:Pneumococcal Vaccines
keywords: 13-valent pneumococcal conjugate vaccine; 7-valent pneumococcal conjugate vaccine; Japan; PCV13; PCV7; Streptococcus pneumoniae; bacteria; capsular type; invasive pneumococcal diseases; macrolide resistance; β-lactam resistance