title: Are we using and monitoring thiopurines and biologics optimally?
abstract: The use of biologics and thiopurines in patients with inflammatory bowel disease has increased rapidly over the last 2 decades with both classes of drugs being used more frequently and earlier in the disease course. This vogue has come about through a realisation that for some patients Crohn's disease and ulcerative colitis are progressive diseases and that use of these therapies can sometimes prevent that progression. However, knowledge about the optimal way in which to use these drugs continues to evolve. In this paper, the evidence regarding optimal timing and dosing of thiopurines and biologics will be reviewed as will the role of thiopurine methyltransferase testing along with therapeutic drug monitoring of both thiopurines and biologics. In addition, possible future applications of biologic drug level and anti-drug antibody testing will be considered.
authors: Department of Gastroenterology, Guy's and St Thomas' Hospital, and Division of Diabetes and Nutritional Sciences, School of Medicine, King's College London, London, UK.
authors: Peter M
authors: PM
authors: Irving
mesh_terms: D000906:Antibodies / Q000378:metabolism; D001688:Biological Products / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy; D011687:Purines / Q000627:therapeutic use*
chemical_list: D000906:Antibodies; D001688:Biological Products; D011687:Purines