title: Brain metastases in non-small-cell lung cancer.
abstract: Up to 50% of patients with advanced non-small-cell lung cancer will develop brain metastases at some point during their illness. These metastases cause a substantial burden in morbidity and mortality, which has motivated research and technological innovation over the past 2 decades. Surgery, radiotherapy, and systemic therapies have each played a role in management, with the greatest changes associated with the popularization of stereotactic radiosurgery. In this review, the evidence behind each modality used in the management of brain metastases for non-small-cell lung cancer patients is examined, and recommendations regarding the current standards of care and areas of future research focus are provided.
authors: Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address: david.dawe@cancercare.mb.ca.
authors: David E
authors: DE
authors: Dawe
authors: Department of Oncology, McMaster University, Hamilton, Ontario, Canada.
authors: Jeffrey N
authors: JN
authors: Greenspoon
authors: Department of Oncology, McMaster University, Hamilton, Ontario, Canada.
authors: Peter M
authors: PM
authors: Ellis
mesh_terms: D000818:Animals; D035843:Biomedical Research; D001932:Brain Neoplasms / Q000556:secondary / Q000628:therapy*; D002289:Carcinoma, Non-Small-Cell Lung / Q000556:secondary / Q000628:therapy*; D004358:Drug Therapy; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000628:therapy*; D058990:Molecular Targeted Therapy; D016634:Radiosurgery; D059039:Standard of Care
keywords: Chemotherapy; Radiotherapy; Review; Stereotactic radiosurgery; Targeted agents