title: Exploring effects of EAAT polymorphisms on cognitive functions in schizophrenia.
abstract: OBJECTIVE
  To evaluate the effect of functional polymorphisms (rs4354668 and rs2731880) of the excitatory amino acid transporters (EAAT1 and 2) on the cognitive dysfunction that characterizes schizophrenia.
  
  
  METHODS
  One hundred and ninety two subjects diagnosed with schizophrenia were assessed with Brief Assessment of Cognition in Schizophrenia, Wisconsin Card Sorting Test, Continuous Performance Test and N-back test and genotyped for rs4354668 and rs2731880.
  
  
  RESULTS
  ANOVA showed a significant difference among both EAAT1 and EAAT2 genotype groups on different cognitive measures. Worse performances were observed among carriers of the genotypes associated with lower EAAT expression.
  
  
  CONCLUSIONS
  RESULTS suggest that impaired activity and EAAT expression could influence cognitive performances in schizophrenia, thus representing a target of interest for development of pharmacological strategies aimed to improve cognition.
authors: San Raffaele Scientific Institute, Department of Clinical Neurosciences, Vita-Salute San Raffale University, Via Stamira d'Ancona 20, 20127 Milano, Italy.
authors: Marco
authors: M
authors: Spangaro
authors: Marta
authors: M
authors: Bosia
authors: Andrea
authors: A
authors: Zanoletti
authors: Margherita
authors: M
authors: Bechi
authors: Buonocore
authors: B
authors: Mariachiara
authors: Adele
authors: A
authors: Pirovano
authors: Cristina
authors: C
authors: Lorenzi
authors: Placido
authors: P
authors: Bramanti
authors: Enrico
authors: E
authors: Smeraldi
authors: Roberto
authors: R
authors: Cavallaro
mesh_terms: D000328:Adult; D003072:Cognition Disorders / Q000150:complications / Q000235:genetics* / Q000473:pathology; D027341:Excitatory Amino Acid Transporter 1 / Q000096:biosynthesis* / Q000235:genetics; D027342:Excitatory Amino Acid Transporter 2; D005260:Female; D005838:Genotype; D050491:Glutamate Plasma Membrane Transport Proteins / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000150:complications / Q000235:genetics* / Q000473:pathology
chemical_list: D027341:Excitatory Amino Acid Transporter 1; D027342:Excitatory Amino Acid Transporter 2; D050491:Glutamate Plasma Membrane Transport Proteins; C493397:SLC1A2 protein, human; C493394:SLC1A3 protein, human
keywords: EAAT1; EAAT2; cognitive impairment; glutamate uptake; schizophrenia