title: Effects of glucocorticoids in potentiating diuresis in heart failure patients with diuretic resistance.
abstract: Diuretic resistance in heart failure is defined as a state in which diuretic response is diminished or lost before the therapeutic goal of relief from congestion has been reached. Diuretic resistance is very common and is associated with poor outcomes. Over the past decade, several new drugs and devices targeting decongestion and improvement in renal function in patients with heart failure have failed to show benefit in randomized clinical trials. Glucocorticoids had been used to manage diuretic resistance before the advent of loop diuretics. More recent evidence appears to confirm that glucocorticoids may also help to overcome resistance to loop diuretics. This review tries to summarize the available evidence and potential mechanisms related to glucocorticoid therapy in patients with heart failure and its effect on diuretic resistance.
authors: Heart Center, First Hospital of Hebei Medical University, Hebei University, Shijiazhuang, People's Republic of China. Electronic address: dr.liuchao@gmail.com.
authors: Chao
authors: C
authors: Liu
authors: Heart Center, First Hospital of Hebei Medical University, Hebei University, Shijiazhuang, People's Republic of China. Electronic address: ksliud@sohu.com.
authors: Kunshen
authors: K
authors: Liu
mesh_terms: D002986:Clinical Trials as Topic; D004231:Diuresis; D004232:Diuretics / Q000627:therapeutic use; D004351:Drug Resistance; D005938:Glucocorticoids / Q000494:pharmacology / Q000627:therapeutic use*; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D051437:Renal Insufficiency / Q000188:drug therapy
chemical_list: D004232:Diuretics; D005938:Glucocorticoids
keywords: Heart failure; diuretic resistance; glucocorticoids