title: Coordinated reset neuromodulation for Parkinson's disease: proof-of-concept study.
abstract: BACKGROUND
  The discovery of abnormal synchronization of neuronal activity in the basal ganglia in Parkinson's disease (PD) has prompted the development of novel neuromodulation paradigms. Coordinated reset neuromodulation intends to specifically counteract excessive synchronization and to induce cumulative unlearning of pathological synaptic connectivity and neuronal synchrony.
  
  
  METHODS
  In this prospective case series, six PD patients were evaluated before and after coordinated reset neuromodulation according to a standardized protocol that included both electrophysiological recordings and clinical assessments.
  
  
  RESULTS
  Coordinated reset neuromodulation of the subthalamic nucleus (STN) applied to six PD patients in an externalized setting during three stimulation days induced a significant and cumulative reduction of beta band activity that correlated with a significant improvement of motor function.
  
  
  CONCLUSIONS
  These results highlight the potential effects of coordinated reset neuromodulation of the STN in PD patients and encourage further development of this approach as an alternative to conventional high-frequency deep brain stimulation in PD.
authors: Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center, Jülich, Germany.
authors: Ilya
authors: I
authors: Adamchic
authors: Christian
authors: C
authors: Hauptmann
authors: Utako Brigit
authors: UB
authors: Barnikol
authors: Norbert
authors: N
authors: Pawelczyk
authors: Oleksandr
authors: O
authors: Popovych
authors: Thomas Theo
authors: TT
authors: Barnikol
authors: Alexander
authors: A
authors: Silchenko
authors: Jens
authors: J
authors: Volkmann
authors: Günter
authors: G
authors: Deuschl
authors: Wassilios G
authors: WG
authors: Meissner
authors: Mohammad
authors: M
authors: Maarouf
authors: Volker
authors: V
authors: Sturm
authors: Hans-Joachim
authors: HJ
authors: Freund
authors: Peter Alexander
authors: PA
authors: Tass
mesh_terms: D000368:Aged; D055592:Biophysical Phenomena; D046690:Deep Brain Stimulation / Q000379:methods*; D004567:Electrodes, Implanted; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology; D010300:Parkinson Disease / Q000503:physiopathology / Q000628:therapy*; D011446:Prospective Studies; D020531:Subthalamic Nucleus / Q000502:physiology*
keywords: DBS; Parkinson's disease; STN; beta band oscillation; coordinated reset neuromodulation