title: Integrating disease knowledge and technology to deliver protein targets and biomarkers into drug discovery projects.
abstract: Biomarker discovery is dependent upon two disciplines: the field of clinical bioanalysis linked to disease aetiology and the application of high level technology platforms for identifying proteins/peptides in complex samples. However, diagnostic biomarker measurements require certain definitions of context that can only be achieved by combining protein science with clinical science. The evaluation of biomarkers requires careful attention to match (1) a specific biological question with (2) the appropriate clinical sample and (3) high resolution technology systems which link protein identities to clinical informatics.:
authors: Department of Biological Sciences, AstraZeneca R&D, Lund, Sweden. Electronic address:Thomas.Fehniger@AstraZeneca.com.
authors: Thomas E
authors: TE
authors: Fehniger
authors: Department of Electrical Measurements, Lund Institute of Technology, Lund University, Lund, Sweden.
authors: Thomas
authors: T
authors: Laurell
authors: Department of Biological Sciences, AstraZeneca R&D, Lund, Sweden.
authors: György
authors: G
authors: Marko-Varga