title: Human papillomavirus and cancerous diseases of the head and neck: a systematic review and meta-analysis.
abstract: The increasing incidence of head and neck cancer (HNSCC) highlights the need to better understand the role of human papillomavirus (HPV) in the development of these cancers. The aims of this study were to conduct a systematic review and a meta-analysis concerning observational studies on the association between HPV infection and HNSCC and to quantify this association, thereby obtaining a reliable estimation of the risk of HPV infection in the development of head and neck cancer. Literature searches were performed using PubMed and Scopus databases. StatsDirect 2.7.8 program was used for the analysis. We found 15 case-control studies, 63 prevalence studies, and no cohort studies. The pooled odds ratio (OR) for all the included case-control studies resulted in a value of 1.63 (95% CI 1.27-2.09; P < 0.0001). The highest pooled OR resulted from the analysis of all the studies that examined HPV 16 genotype in association oral cavity (OR 5.36; 95% CI 1.4-20). The strong evidence of association between HPV infection and HNSCC highlights the importance of the introduction of specific tests in the cancer prevention practices to evaluate the presence of the virus, especially in the oral cavity, and the possibility of an extension of the vaccine anti-HPV in the male population too.
authors: Department of Public Health and Infectious Diseases, "Sapienza" University of Rome, Rome, Italy.
authors: R
authors: R
authors: Saulle
authors: L
authors: L
authors: Semyonov
authors: A
authors: A
authors: Mannocci
authors: A
authors: A
authors: Careri
authors: F
authors: F
authors: Saburri
authors: L
authors: L
authors: Ottolenghi
authors: F
authors: F
authors: Guerra
authors: G
authors: G
authors: La Torre
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000821:virology*; D016022:Case-Control Studies; D006258:Head and Neck Neoplasms / Q000821:virology*; D006801:Humans; D064887:Observational Studies as Topic; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000821:virology*; D000077195:Squamous Cell Carcinoma of Head and Neck
keywords: head and neck cancer; human papillomavirus; meta-analysis; observational studies; risk; systematic review