title: Differential in vitro inhibition studies of some cerium vanadate derivatives on xanthine oxidase.
abstract: In this preliminary study, a new series of some cerium vanadate derivatives have been investigated as new type of inhibitors of xanthine oxidase (XO; E.C 1.17.3.2). XO is a superoxide-producing enzyme found normally in serum and the lungs, and its activity is concerned with several important health problems such as gout, severe liver damage, vascular dysfunction and injury, oxidative eye injury and renal failure. In this study, we present a critical overview of the effects of these novel type agents on XO with comparing the efficacy and safety profiles of allopurinol, the efficient classical inhibitor of XO.
authors: Department of Chemistry, Science and Art Faculty, Balikesir University , Balikesir , Turkey .
authors: Mustafa Oğuzhan
authors: MO
authors: Kaya
authors: Yeşim
authors: Y
authors: Kaya
authors: Gülşah
authors: G
authors: Çelik
authors: Figen
authors: F
authors: Kurtuluş
authors: Oktay
authors: O
authors: Arslan
authors: Özen Özensoy
authors: ÖÖ
authors: Güler
mesh_terms: D000493:Allopurinol / Q000009:adverse effects / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D066298:In Vitro Techniques; D007700:Kinetics; D008274:Magnesium / Q000737:chemistry; D008892:Milk / Q000201:enzymology; D014638:Vanadates / Q000737:chemistry / Q000494:pharmacology*; D014961:X-Ray Diffraction; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D014638:Vanadates; D000493:Allopurinol; D014969:Xanthine Oxidase; D008274:Magnesium; D002118:Calcium
keywords: Cerium vanadate derivatives; inhibition; xanthine oxidase