title: Population-based analysis of invasive fungal infections, France, 2001-2010.
abstract: To determine the epidemiology and trends of invasive fungal infections (IFIs) in France, we analyzed incidence, risk factors, and in-hospital death rates related to the most frequent IFIs registered in the national hospital discharge database during 2001-2010. The identified 35,876 IFI cases included candidemia (43.4%), Pneumocystis jirovecii pneumonia (26.1%), invasive aspergillosis (IA, 23.9%), cryptococcosis (5.2%), and mucormycosis (1.5%). The overall incidence was 5.9/100,000 cases/year and the mortality rate was 27.6%; both increased over the period (+1.5%, +2.9%/year, respectively). Incidences substantially increased for candidemia, IA, and mucormycosis. Pneumocystis jirovecii pneumonia incidence decreased among AIDS patients (-14.3%/year) but increased in non-HIV-infected patients (+13.3%/year). Candidemia and IA incidence was increased among patients with hematologic malignancies (>+4%/year) and those with chronic renal failure (>+10%/year). In-hospital deaths substantially increased in some groups, e.g., in those with hematologic malignancies. IFIs occur among a broad spectrum of non-HIV-infected patients and should be a major public health priority.
authors: Dounia
authors: D
authors: Bitar
authors: Olivier
authors: O
authors: Lortholary
authors: Yann
authors: Y
authors: Le Strat
authors: Javier
authors: J
authors: Nicolau
authors: Bruno
authors: B
authors: Coignard
authors: Pierre
authors: P
authors: Tattevin
authors: Didier
authors: D
authors: Che
authors: Françoise
authors: F
authors: Dromer
mesh_terms: D000328:Adult; D000368:Aged; D001228:Aspergillosis / Q000453:epidemiology / Q000382:microbiology / Q000401:mortality; D058387:Candidemia / Q000453:epidemiology / Q000382:microbiology / Q000401:mortality; D003453:Cryptococcosis / Q000453:epidemiology / Q000382:microbiology / Q000401:mortality; D005260:Female; D005602:France / Q000453:epidemiology; D015658:HIV Infections / Q000382:microbiology; D019337:Hematologic Neoplasms / Q000453:epidemiology / Q000382:microbiology / Q000401:mortality; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D045363:Pneumocystis carinii; D011020:Pneumonia, Pneumocystis / Q000453:epidemiology / Q000382:microbiology / Q000401:mortality; D012307:Risk Factors
keywords: Invasive mycosis; Pneumocystis jirovecii; aspergillosis; candidemia; cryptococcosis; mucormycosis