title: Design and in vitro biocompatibility of a novel ocular drug delivery device.
abstract: The capsule drug ring (CDR) is a reservoir and delivery agent, which is designed to be placed within the capsular bag during cataract surgery. Prototypes were manufactured by hot melt extrusion of Bionate II®, a polycarbonate urethane. The devices have been optimized using Avastin® as the drug of interest. In vitro biocompatibility was assessed with human lens epithelial cell (B-3), mouse macrophage (J774A.1) and mouse fibroblast (L-929) cell lines. Cell migration and proliferation were assessed after in vitro culture. Pro-inflammatory cytokines (i.e., MIP-1β, MIP-1α, MCP-1, IL-1β, TNF and TGF-β1) were quantified using cytometric bead array (CBA). Preliminary in vivo biocompatibility and pharmacokinetics testing has been performed in rabbits.
authors: Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA. nate.gooch@utah.edu.
authors: Nathan
authors: N
authors: Gooch
authors: Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA. rmikeburr@gmail.com.
authors: Randon Michael
authors: RM
authors: Burr
authors: Department of Cardiothoracic Surgery, University of Utah, Salt Lake City, UT 84112, USA. Dolly.Holt@utah.edu.
authors: Dolly J
authors: DJ
authors: Holt
authors: Department of Mechanical Engineering, University of Utah, Salt Lake City, UT 84112, USA. bruce.gale@utah.edu.
authors: Bruce
authors: B
authors: Gale
authors: Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA. bala.ambati@utah.edu.
authors: Balamurali
authors: B
authors: Ambati