title: Association between CD14 gene polymorphisms and cancer risk: a meta-analysis.
abstract: BACKGROUND
  Two polymorphisms, -260C/T and -651C/T, in the CD14 gene have been implicated in susceptibility to cancer. However, the results remain inconclusive. This meta-analysis aimed to investigate the association between the two polymorphisms and risk of cancer.
  
  
  METHODS
  All eligible case-control studies published up to March 2014 were identified by searching PubMed, Web of Science, CNKI and WanFang database. Pooled odds ratio (OR) with 95% confidence interval (CI) were used to access the strength of this association in fixed- or random-effects model.
  
  
  RESULTS
  17 case-control studies from fourteen articles were included. Of those, there were 17 studies (4198 cases and 4194 controls) for -260C/T polymorphism and three studies (832 cases and 1190 controls) for -651C/T polymorphism. Overall, no significant associations between the two polymorphisms of CD14 gene and cancer risk were found. When stratified by ethnicity, cancer type and source of control, similar results were observed among them. In addition, in further subgroups analysis by Helicobacter pylori (H. pylori) infection status and tumor location in gastric cancer subgroup, we found that the CD14 -260C/T polymorphism may increase the risk of gastric cancer in H. pylori-infected individuals.
  
  
  CONCLUSIONS
  This meta-analysis suggests that the CD14 -260C/T polymorphism may increase the risk of gastric cancer in H. pylori-infected individuals. However, large and well-designed studies are warranted to validate our findings.
authors: Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, People's Republic of China.
authors: Jun
authors: J
authors: Wang
authors: Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, People's Republic of China.
authors: Xufeng
authors: X
authors: Guo
authors: Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, People's Republic of China.
authors: Shijie
authors: S
authors: Yu
authors: Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, People's Republic of China.
authors: Jia
authors: J
authors: Song
authors: Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, People's Republic of China.
authors: Jixiang
authors: J
authors: Zhang
authors: Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, People's Republic of China.
authors: Zhuo
authors: Z
authors: Cao
authors: Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, People's Republic of China.
authors: Jing
authors: J
authors: Wang
authors: Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, People's Republic of China.
authors: Min
authors: M
authors: Liu
authors: Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, People's Republic of China.
authors: Weiguo
authors: W
authors: Dong
mesh_terms: D044466:Asian People; D016022:Case-Control Studies; D005260:Female; D015870:Gene Expression; D016481:Helicobacter Infections / Q000150:complications / Q000208:ethnology / Q000235:genetics* / Q000382:microbiology; D016480:Helicobacter pylori / Q000472:pathogenicity; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000235:genetics*; D008297:Male; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D012306:Risk; D013274:Stomach Neoplasms / Q000208:ethnology / Q000209:etiology / Q000235:genetics* / Q000382:microbiology; D044465:White People
chemical_list: D018950:Lipopolysaccharide Receptors