title: Value of plasmatic membrane attack complex as a marker of severity in acute kidney injury.
abstract: The aim of this study was to determine if complement pathway is activated in AKI; for this purpose, we measured, through ELISA sandwich, the terminal lytic fraction of the complement system, called membrane attack complex (C5b-C9), in AKI patients compared with patients with similar clinical conditions but normal renal function. Our data showed that complement system is activated in AKI. Plasmatic MAC concentrations were significantly higher in AKI patients than in those with normal renal function; this difference is maintained independently of the AKI etiology and is proportional to the severity of AKI, measured by ADQI classification. In addition, we found that plasmatic MAC concentrations were significantly higher in patients who did not recover renal function at time of hospitalization discharge, in patients who died during the acute process, and in patients who need renal replacement therapy during hospitalization, but in this last group, the differences did not reach statistical significance. In conclusion, plasmatic MAC concentration seems valuable as a marker of AKI severity.
authors: Departamento de Nefrología, Hospital del Mar, Passeig Marítim 25-29, 08003 Barcelona, Spain ; Nefrología Grupo de Investigación, Institut Mar d'Investigacions Médiques, Carrer del Doctor Aiguader 88, 08003 Barcleona, Spain.
authors: Eva
authors: 0000-0002-4397-162X
authors: E
authors: Rodríguez
authors: Departamento de Nefrología, Hospital del Mar, Passeig Marítim 25-29, 08003 Barcelona, Spain ; Nefrología Grupo de Investigación, Institut Mar d'Investigacions Médiques, Carrer del Doctor Aiguader 88, 08003 Barcleona, Spain.
authors: Marta
authors: 0000-0003-4362-7965
authors: M
authors: Riera
authors: Departamento de Nefrología, Hospital del Mar, Passeig Marítim 25-29, 08003 Barcelona, Spain ; Nefrología Grupo de Investigación, Institut Mar d'Investigacions Médiques, Carrer del Doctor Aiguader 88, 08003 Barcleona, Spain.
authors: Clara
authors: C
authors: Barrios
authors: Departamento de Nefrología, Hospital del Mar, Passeig Marítim 25-29, 08003 Barcelona, Spain ; Nefrología Grupo de Investigación, Institut Mar d'Investigacions Médiques, Carrer del Doctor Aiguader 88, 08003 Barcleona, Spain.
authors: Julio
authors: 0000-0002-4735-7838
authors: J
authors: Pascual
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood* / Q000628:therapy; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D015938:Complement Membrane Attack Complex / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017582:Renal Replacement Therapy; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D015938:Complement Membrane Attack Complex