title: Neutron capture therapy: a comparison between dose enhancement of various agents, nanoparticles and chemotherapy drugs.
abstract: The aim of this study is to compare dose enhancement of various agents, nanoparticles and chemotherapy drugs for neutron capture therapy. A (252)Cf source was simulated to obtain its dosimetric parameters, including air kerma strength, dose rate constant, radial dose function and total dose rates. These results were compared with previously published data. Using (252)Cf as a neutron source, the in-tumour dose enhancements in the presence of atomic (10)B, (157)Gd and (33)S agents; (10)B, (157)Gd, (33)S nanoparticles; and Bortezomib and Amifostine chemotherapy drugs were calculated and compared in neutron capture therapy. Monte Carlo code MCNPX was used for simulation of the (252)Cf source, a soft tissue phantom, and a tumour containing each capture agent. Dose enhancement for 100, 200 and 500 ppm of the mentioned media was calculated. Calculated dosimetric parameters of the (252)Cf source were in agreement with previously published values. In comparison to other agents, maximum dose enhancement factor was obtained for 500 ppm of atomic (10)B agent and (10)B nanoparticles, equal to 1.06 and 1.08, respectively. Additionally, Bortezomib showed a considerable dose enhancement level. From a dose enhancement point of view, media containing (10)B are the best agents in neutron capture therapy. Bortezomib is a chemotherapy drug containing boron and can be proposed as an agent in boron neutron capture therapy. However, it should be noted that other physical, chemical and medical criteria should be considered in comparing the mentioned agents before their clinical use in neutron capture therapy.
authors: Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.
authors: Mohsen
authors: M
authors: Khosroabadi
authors: Mahdi
authors: M
authors: Ghorbani
authors: Faezeh
authors: F
authors: Rahmani
authors: Courtney
authors: C
authors: Knaup
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D053758:Nanoparticles / Q000627:therapeutic use*; D017247:Neutron Capture Therapy / Q000379:methods*; D011879:Radiotherapy Dosage
chemical_list: D000970:Antineoplastic Agents