title: First case of disseminated cryptococcosis in a Gorilla gorilla.
abstract: In humans, Cryptococcus mainly infects individuals with HIV infection or other types of immunosuppression. Here, we report the first case of disseminated cryptococcosis in a simian immunodeficiency virus-negative 27-year-old female Gorilla gorilla presenting with lethargy, progressive weight loss and productive cough. The diagnosis was confirmed by positive lung biopsy culture, serum cryptococcal antigen, and cerebral histopathology demonstrating encapsulated yeasts. Molecular characterisation of lung culture isolate yielded Cryptococcus neoformans var. grubii. An immune-deficiency could not be demonstrated.
authors: Department of Infectious Diseases, Medical Microbiology and Hygiene, Heidelberg University Hospital, Heidelberg, Germany.
authors: Alexander
authors: A
authors: Mischnik
authors: Julia
authors: J
authors: Stockklausner
authors: Nicole
authors: N
authors: Hohneder
authors: Henrik E
authors: HE
authors: Jensen
authors: Stefan
authors: S
authors: Zimmermann
authors: David E
authors: DE
authors: Reuss
authors: Volker
authors: V
authors: Rickerts
authors: Kathrin
authors: K
authors: Tintelnot
authors: Clemens
authors: C
authors: Stockklausner
mesh_terms: D000818:Animals; D001921:Brain / Q000382:microbiology / Q000473:pathology; D003453:Cryptococcosis / Q000175:diagnosis / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D003454:Cryptococcus / Q000302:isolation & purification* / Q000502:physiology; D005260:Female; D006071:Gorilla gorilla / Q000382:microbiology*; D018419:Primate Diseases / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology
keywords: Cryptococcus; gorilla; meningoencephalitis; mucicarmine