title: [Pathophysiology and pathogenesis of Salmonella sepsis].
abstract: The authors present a review of current knowledge about complex pathogenetic and pathophysiologic mechanisms involved in the development of sepsis in salmonellosis. Mechanisms such as lipopolysacharide-induced NOD-like receptor activation, escaping lysosomal degradation, intracellular replication niche formation, cytoskeleton reorganization, proapoptotic mechanism induction, changes in cytokine levels (IL-1β, TNF-α) and function of omptin proteases are discussed.
authors: Department of Infectious Diseases, Faculty of Medicine, Masaryk University and University Hospital in Brno, Czech Republic, e-mail: pavel.polak@fnbrno.cz.
authors: P
authors: P
authors: Polák
authors: J
authors: J
authors: Juránková
authors: P
authors: P
authors: Husa
mesh_terms: D016470:Bacteremia; D016207:Cytokines / Q000097:blood; D006801:Humans; D012475:Salmonella; D012480:Salmonella Infections; D018805:Sepsis
chemical_list: D016207:Cytokines