title: Rheology of semiflexible bundle networks with transient linkers.
abstract: We present a theoretical and computational analysis of the rheology of networks made up of bundles of semiflexible filaments bound by transient cross-linkers. Such systems are ubiquitous in the cytoskeleton and can be formed in vitro using filamentous actin and various cross-linkers. We find that their high-frequency rheology is characterized by a scaling behavior that is quite distinct from that of networks of the well-studied single semiflexible filaments. This regime can be understood theoretically in terms of a length-scale-dependent bending modulus for bundles. Next, we observe new dissipative dynamics associated with the shear-induced disruption of the network at intermediate frequencies. Finally, at low frequencies, we encounter a region of non-Newtonian rheology characterized by power-law scaling. This regime is dominated by bundle dissolution and large-scale rearrangements of the network driven by equilibrium thermal fluctuations.
authors: Institute for Computational Mechanics, Technische Universität München, 85748 Garching, Germany.
authors: Kei W
authors: KW
authors: Müller
authors: Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095-1596, USA and Department of Physics and Astronomy, UCLA, Los Angeles, California 90095-1596, USA.
authors: Robijn F
authors: RF
authors: Bruinsma
authors: Institute for Medical Engineering IMETUM, Technische Universität München, 85748 Garching, Germany.
authors: Oliver
authors: O
authors: Lieleg
authors: Lehrstuhl für Zellbiophysik E27, Physik Department, Technische Universität München, 85748 Garching, Germany.
authors: Andreas R
authors: AR
authors: Bausch
authors: Institute for Computational Mechanics, Technische Universität München, 85748 Garching, Germany.
authors: Wolfgang A
authors: WA
authors: Wall
authors: Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095-1596, USA and Department of Physics and Astronomy, UCLA, Los Angeles, California 90095-1596, USA and Department of Biomathematics, UCLA, Los Angeles, California 90095-1596, USA.
authors: Alex J
authors: AJ
authors: Levine
mesh_terms: D000199:Actins / Q000737:chemistry*; D002352:Carrier Proteins / Q000737:chemistry; D003599:Cytoskeleton / Q000737:chemistry*; D008840:Microfilament Proteins / Q000737:chemistry; D008956:Models, Chemical; D012212:Rheology / Q000379:methods*; D014783:Viscosity
chemical_list: D000199:Actins; D002352:Carrier Proteins; D008840:Microfilament Proteins; C020324:fascin