title: [Hypertension, chronic kidney disease and genetics in patients with African ancestry].
abstract: The incidence and prevalence of hypertension is markedly elevated in Afro-American populations vs Caucasians. The development of end-stage renal disease is also more frequent in Afro-American subjects, independently of blood pressure control. As compared to Caucasians, Afro-American subjects have a higher risk of end-stage renal disease when they are infected with HIV or have lupus. For decades, these data remained mysterious. Within the last 3 years, results from studies in the field of genetics and infectious diseases have transformed our view on this problem. The aim of this paper is to explain how these results have changed our understanding of hypertension and its consequences in Afro-American subjects.
authors: Service de néphrologie-immunologie clinique, hôpital Bretonneau, EA 4245, université François-Rabelais, 2, boulevard Tonnellé, 37000 Tours, France. Electronic address: halimi@med.univ-tours.fr.
authors: J-M
authors: JM
authors: Halimi
mesh_terms: D001741:Black or African American / Q000235:genetics / Q000706:statistics & numerical data; D016632:Apolipoprotein A-I / Q000097:blood / Q000235:genetics*; D001053:Apolipoproteins / Q000235:genetics; D015415:Biomarkers / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics*; D015994:Incidence; D009154:Mutation / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics; D015995:Prevalence; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics*; D012307:Risk Factors; D014353:Trypanosomiasis, African / Q000235:genetics; D014481:United States / Q000453:epidemiology; D044465:White People / Q000235:genetics / Q000706:statistics & numerical data
chemical_list: D016632:Apolipoprotein A-I; D001053:Apolipoproteins; D015415:Biomarkers; C049537:apolipoprotein G
keywords: Afro-American; Apolipoprotein; Apolipoprotéine; Chronic renal disease; Genetic; Génétique; Hypertension; Insuffisance rénale chronique; Sujets noirs; Trypanosomiase; Trypanosomiasis