title: Diagnostic accuracy and functional parameters of myocardial perfusion scintigraphy using accelerated cardiac acquisition with IQ SPECT technique in comparison to conventional imaging.
abstract: BACKGROUND
  IQ SPECT consists of a new pinhole-like collimator, cardio-centric acquisition, and advanced 3D iterative SPECT reconstruction. The aim of this paper was to compare diagnostic accuracy and functional parameters obtained with IQ SPECT versus conventional SPECT in patients undergoing myocardial perfusion scintigraphy with adenosine stress and at rest.
  
  
  METHODS
  Eight patients with known or suspected coronary artery disease underwent [99mTc] tetrofosmin gated SPECT. Acquisition was performed on a Symbia T6 equipped with IQ SPECT and on a conventional gamma camera system. Gated SPECT data were used to calculate functional parameters. Scores analysis was performed on a 17-segment model. Coronary angiography and clinical follow-up were considered as diagnostic reference standard.
  
  
  RESULTS
  Mean acquisition time was 4 minutes with IQ SPECT and 21 minutes with conventional SPECT. Agreement degree on the diagnostic accuracy between both systems was 0.97 for stress studies, 0.91 for rest studies and 0.96 for both studies. Perfusion abnormalities scores obtained by using IQ SPECT and conventional SPECT were not significant different: SSS, 9.7±8.8 and 10.1±6.4; SRS, 7.1±6.1 and 7.5±7.3; SDS, 4.0±6.1 and 3.9±4.3, respectively. However, a significant difference was found in functional parameters derived from IQ SPECT and conventional SPECT both after stress and at rest. Mean LVEF was 8% lower using IQ SPECT. Differences in LVEF were found in patients with normal LVEF and patients with reduced LVEF.
  
  
  CONCLUSIONS
  Functional parameters using accelerated cardiac acquisition with IQ SPECT are significantly different to those obtained with conventional SPECT, while agreement for clinical interpretation of myocardial perfusion scintigraphy with both techniques is high.
authors: Department of Nuclear Medicine and Endocrinology, Paracelsus Medical University Salzburg, Salzburg, Austria - c.pirich@salk.at.
authors: Christian
authors: C
authors: Pirich
authors: Department of Nuclear Medicine and Endocrinology, Paracelsus Medical University Salzburg, Salzburg, Austria.
authors: Peter
authors: P
authors: Keinrath
authors: Department of Nuclear Medicine and Endocrinology, Paracelsus Medical University Salzburg, Salzburg, Austria.
authors: Gabriele
authors: G
authors: Barth
authors: Department of Nuclear Medicine and Endocrinology, Paracelsus Medical University Salzburg, Salzburg, Austria.
authors: Gundula
authors: G
authors: Rendl
authors: Department of Nuclear Medicine and Endocrinology, Paracelsus Medical University Salzburg, Salzburg, Austria.
authors: Lukas
authors: L
authors: Rettenbacher
authors: Department of Nuclear Medicine and Endocrinology, Paracelsus Medical University Salzburg, Salzburg, Austria.
authors: Margarida
authors: M
authors: Rodrigues
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000503:physiopathology; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging; D012146:Rest; D012680:Sensitivity and Specificity; D013312:Stress, Physiological; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon