title: The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse.
authors: Department of Pediatric Oncology, Hematology and Immunology, Children's Hospital, University of Heidelberg, Germany Molecular Medicine Partnership Unit, EMBL-University of Heidelberg, Germany.
authors: Obul R
authors: OR
authors: Bandapalli
authors: Department of Pediatric Oncology, Hematology and Immunology, Children's Hospital, University of Heidelberg, Germany Molecular Medicine Partnership Unit, EMBL-University of Heidelberg, Germany.
authors: Stephanie
authors: S
authors: Schuessele
authors: Department of Pediatric Oncology, Hematology and Immunology, Children's Hospital, University of Heidelberg, Germany Molecular Medicine Partnership Unit, EMBL-University of Heidelberg, Germany.
authors: Joachim B
authors: JB
authors: Kunz
authors: European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany.
authors: Tobias
authors: T
authors: Rausch
authors: European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany.
authors: Adrian M
authors: AM
authors: Stütz
authors: Childhood Leukemia Research Institute and Department of Pediatric Hemato-Oncology, Sheba Medical Center, Tel Hashomer, and Tel Aviv University, Israel.
authors: Noa
authors: N
authors: Tal
authors: Childhood Leukemia Research Institute and Department of Pediatric Hemato-Oncology, Sheba Medical Center, Tel Hashomer, and Tel Aviv University, Israel Division of Biological Sciences and Department of Medicine Stem Cell Program, University of California, San Diego, La Jolla, CA, USA.
authors: Ifat
authors: I
authors: Geron
authors: Childhood Leukemia Research Institute and Department of Pediatric Hemato-Oncology, Sheba Medical Center, Tel Hashomer, and Tel Aviv University, Israel.
authors: Nava
authors: N
authors: Gershman
authors: Childhood Leukemia Research Institute and Department of Pediatric Hemato-Oncology, Sheba Medical Center, Tel Hashomer, and Tel Aviv University, Israel.
authors: Shai
authors: S
authors: Izraeli
authors: Department of Pediatric Oncology, Hematology and Immunology, Children's Hospital, University of Heidelberg, Germany Molecular Medicine Partnership Unit, EMBL-University of Heidelberg, Germany.
authors: Juliane
authors: J
authors: Eilers
authors: Department of Pediatric Oncology, Hematology and Immunology, Children's Hospital, University of Heidelberg, Germany Molecular Medicine Partnership Unit, EMBL-University of Heidelberg, Germany.
authors: Nina
authors: N
authors: Vaezipour
authors: Department of Pediatric Oncology/Hematology, Charité - Universitätsmedizin Berlin, Germany.
authors: Renate
authors: R
authors: Kirschner-Schwabe
authors: Department of Pediatric Oncology/Hematology, Charité - Universitätsmedizin Berlin, Germany German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors: Jana
authors: J
authors: Hof
authors: Department of Pediatric Oncology/Hematology, Charité - Universitätsmedizin Berlin, Germany.
authors: Arend
authors: A
authors: von Stackelberg
authors: Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Germany.
authors: Martin
authors: M
authors: Schrappe
authors: Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Germany Department of Pediatric Hematology/Oncology, Medical School Hannover, Germany.
authors: Martin
authors: M
authors: Stanulla
authors: Department of Pediatric Hematology/Oncology, Medical School Hannover, Germany.
authors: Martin
authors: M
authors: Zimmermann
authors: Department of Human Genetics, University of Heidelberg, Germany.
authors: Rolf
authors: R
authors: Koehler
authors: Molecular Oncology, Felsenstein Medical Research Center and Pediatric Hematology Oncology, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.
authors: Smadar
authors: S
authors: Avigad
authors: Children's Hospital, University Hospital Tübingen, Germany.
authors: Rupert
authors: R
authors: Handgretinger
authors: Department of Oncology, University Children's Hospital Zurich, Switzerland.
authors: Viktoras
authors: V
authors: Frismantas
authors: Department of Oncology, University Children's Hospital Zurich, Switzerland.
authors: Jean Pierre
authors: JP
authors: Bourquin
authors: Department of Oncology, University Children's Hospital Zurich, Switzerland.
authors: Beat
authors: B
authors: Bornhauser
authors: European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany Jan.korbel@embl-heidelberg.de Martina.Muckenthaler@med.uni-heidelberg.de Andreas.Kulozik@med.uni-heidelberg.de.
authors: Jan O
authors: JO
authors: Korbel
authors: Department of Pediatric Oncology, Hematology and Immunology, Children's Hospital, University of Heidelberg, Germany Molecular Medicine Partnership Unit, EMBL-University of Heidelberg, Germany Jan.korbel@embl-heidelberg.de Martina.Muckenthaler@med.uni-heidelberg.de Andreas.Kulozik@med.uni-heidelberg.de.
authors: Martina U
authors: MU
authors: Muckenthaler
authors: Department of Pediatric Oncology, Hematology and Immunology, Children's Hospital, University of Heidelberg, Germany Molecular Medicine Partnership Unit, EMBL-University of Heidelberg, Germany Jan.korbel@embl-heidelberg.de Martina.Muckenthaler@med.uni-heidelberg.de Andreas.Kulozik@med.uni-heidelberg.de.
authors: Andreas E
authors: AE
authors: Kulozik
mesh_terms: D002648:Child; D002675:Child, Preschool; D006801:Humans; D009154:Mutation; D009364:Neoplasm Recurrence, Local; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000473:pathology*; D050799:STAT5 Transcription Factor / Q000235:genetics*
chemical_list: D050799:STAT5 Transcription Factor; C494095:STAT5B protein, human
keywords: STAT5B; mutation; pediatric T-ALL