title: Smooth pursuit eye movements and schizophrenia: literature review.
abstract: OBJECTIVE
  To review the scientific literature about the relationship between impairment on smooth pursuit eye movements and schizophrenia.
  
  
  METHODS
  Narrative review that includes historical articles, reports about basic and clinical investigation, systematic reviews, and meta-analysis on the topic.
  
  
  RESULTS
  Up to 80% of schizophrenic patients have impairment of smooth pursuit eye movements. Despite the diversity of test protocols, 65% of patients and controls are correctly classified by their overall performance during this pursuit. The smooth pursuit eye movements depend on the ability to anticipate the target's velocity and the visual feedback, as well as on learning and attention. The neuroanatomy implicated in smooth pursuit overlaps to some extent with certain frontal cortex zones associated with some clinical and neuropsychological characteristics of the schizophrenia, therefore some specific components of smooth pursuit anomalies could serve as biomarkers of the disease. Due to their sedative effect, antipsychotics have a deleterious effect on smooth pursuit eye movements, thus these movements cannot be used to evaluate the efficacy of the currently available treatments.
  
  
  CONCLUSIONS
  Standardized evaluation of smooth pursuit eye movements on schizophrenia will allow to use specific aspects of that pursuit as biomarkers for the study of its genetics, psychopathology, or neuropsychology.
authors: Hospital Universitari Institut Pere Mata. Universitat Rovira i Virgili, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Institut d'Investigació Sanitària Pere Virgili, IISPV, Reus, Tarragona, España. Electronic address: josefranco11@hotmail.com.
authors: J G
authors: JG
authors: Franco
authors: Hospital Universitari Institut Pere Mata. Universitat Rovira i Virgili, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Institut d'Investigació Sanitària Pere Virgili, IISPV, Reus, Tarragona, España.
authors: J
authors: J
authors: de Pablo
authors: Hospital Universitari Institut Pere Mata. Universitat Rovira i Virgili, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Institut d'Investigació Sanitària Pere Virgili, IISPV, Reus, Tarragona, España.
authors: A M
authors: AM
authors: Gaviria
authors: Hospital Universitari Institut Pere Mata. Universitat Rovira i Virgili, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Institut d'Investigació Sanitària Pere Virgili, IISPV, Reus, Tarragona, España.
authors: E
authors: E
authors: Sepúlveda
authors: Hospital Universitari Institut Pere Mata. Universitat Rovira i Virgili, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Institut d'Investigació Sanitària Pere Virgili, IISPV, Reus, Tarragona, España.
authors: E
authors: E
authors: Vilella
mesh_terms: D001921:Brain / Q000033:anatomy & histology / Q000503:physiopathology; D006801:Humans; D011698:Pursuit, Smooth; D012559:Schizophrenia / Q000503:physiopathology*
keywords: Biological markers; Esquizofrenia; Fenotipo; Marcadores biológicos; Neuro-ophthalmology; Neurooftalmología; Neuropsicología; Neuropsiquiatría; Neuropsychiatry; Neuropsychology; Phenotype; Schizophrenia; Seguimiento ocular uniforme; Smooth pursuit