title: An emulsion restores the skin barrier by decreasing the skin pH and inflammation in a canine experimental model.
abstract: The aim of this study was to investigate the effect of Douxo(®) Calm Mousse (Sogeval, Laval, France) on restoration of the skin barrier in a canine model of barrier disruption. Tape strips were performed, daily for 6 days, on the lateral thorax of five healthy beagle dogs. Douxo(®) Calm Mousse was applied daily for 5 days to one side of the thorax and the opposite side was left untreated. The effects of treatment were evaluated by measurement of transepidermal water loss (TEWL) and pH and by histological assessment of disrupted skin at various times during barrier repair. Although no effect on TEWL was observed, Douxo(®) Calm Mousse maintained an acidic pH after three applications and reduced skin inflammation, which was most pronounced after five applications. The results of the study suggest that Douxo(®) Calm Mousse exerts a beneficial effect on barrier restoration and on markers of inflammation.
authors: Interactions Cellules Environnement UPSP 2011.03.101, Unité Dermatologie, Laboratoire de Dermatopathologie, VetAgro Sup Campus Vétérinaire de Lyon, Marcy l'Etoile F-69280, France. Electronic address: didier.pin@vetagro-sup.fr.
authors: D
authors: D
authors: Pin
authors: VetAgro Sup Campus Vétérinaire de Lyon Marcy l'Etoile F-69280, France.
authors: M
authors: M
authors: Bekrich
authors: Interactions Cellules Environnement UPSP 2011.03.101, Unité Dermatologie, Laboratoire de Dermatopathologie, VetAgro Sup Campus Vétérinaire de Lyon, Marcy l'Etoile F-69280, France.
authors: O
authors: O
authors: Fantini
authors: Biovivo Institut Claude Bourgelat, VetAgro Sup Campus Vétérinaire de Lyon, Marcy l'Etoile F-69280, France.
authors: G
authors: G
authors: Noel
authors: Interactions Cellules Environnement UPSP 2011.03.101, Unité Dermatologie, Laboratoire de Dermatopathologie, VetAgro Sup Campus Vétérinaire de Lyon, Marcy l'Etoile F-69280, France.
authors: E
authors: E
authors: Vidémont
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D002518:Ceramides / Q000008:administration & dosage; D004195:Disease Models, Animal; D004285:Dogs; D004655:Emulsions / Q000008:administration & dosage; D006863:Hydrogen-Ion Concentration; D007249:Inflammation / Q000473:pathology; D010938:Plant Oils / Q000008:administration & dosage; D012867:Skin / Q000187:drug effects* / Q000293:injuries / Q000473:pathology; D013110:Sphingosine / Q000008:administration & dosage / Q000031:analogs & derivatives; D062367:ortho-Aminobenzoates / Q000008:administration & dosage
chemical_list: D000893:Anti-Inflammatory Agents; D002518:Ceramides; D004655:Emulsions; D010938:Plant Oils; D062367:ortho-Aminobenzoates; C514463:avenanthramide-2C; C012491:phytosphingosine; D013110:Sphingosine
keywords: dog; inflammation; skin barrier disruption