title: Intravenously administered nanoparticles increase survival following blast trauma.
abstract: Explosions account for 79% of combat-related injuries, leading to multiorgan hemorrhage and uncontrolled bleeding. Uncontrolled bleeding is the leading cause of death in battlefield traumas as well as in civilian life. We need to stop the bleeding quickly to save lives, but, shockingly, there are no treatments to stop internal bleeding. A therapy that halts bleeding in a site-specific manner and is safe, stable at room temperature, and easily administered is critical for the advancement of trauma care. To address this need, we have developed hemostatic nanoparticles that are administered intravenously. When tested in a model of blast trauma with multiorgan hemorrhaging, i.v. administration of the hemostatic nanoparticles led to a significant improvement in survival over the short term (1 h postblast). No complications from this treatment were apparent out to 3 wk. This work demonstrates that these particles have the potential to save lives and fundamentally change trauma care.
authors: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106;
authors: Margaret M
authors: MM
authors: Lashof-Sullivan
authors: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106;
authors: Erin
authors: E
authors: Shoffstall
authors: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106;
authors: Kristyn T
authors: KT
authors: Atkins
authors: Department of Biomedical Engineering, Wayne State University, Detroit, MI 48201; and.
authors: Nickolas
authors: N
authors: Keane
authors: Department of Biomedical Engineering, Wayne State University, Detroit, MI 48201; and.
authors: Cynthia
authors: C
authors: Bir
authors: School of Biomedical Engineering and Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061.
authors: Pamela
authors: P
authors: VandeVord
authors: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106; erin.lavik@case.edu.
authors: Erin B
authors: EB
authors: Lavik
mesh_terms: D061605:Administration, Intravenous; D000818:Animals; D001753:Blast Injuries / Q000188:drug therapy* / Q000473:pathology; D004195:Disease Models, Animal; D006470:Hemorrhage / Q000188:drug therapy* / Q000473:pathology; D006490:Hemostatics / Q000494:pharmacology*; D008297:Male; D051379:Mice; D053758:Nanoparticles; D013997:Time Factors; D014857:Warfare
chemical_list: D006490:Hemostatics
keywords: clot; lung; medic; polytrauma; synthetic platelets