title: Family chaos and adolescent inflammatory profiles: the moderating role of socioeconomic status.
abstract: OBJECTIVE
  To test whether family chaos influences adolescents' inflammatory profiles and whether adolescents from low socioeconomic status (SES) environments are at higher risk for experiencing adverse inflammatory profiles from living in chaotic family environments.
  
  
  METHODS
  A total of 244 families with an adolescent aged 13 to 16 years participated. Parents completed measures of family SES and family chaos. Both systemic inflammation and stimulated proinflammatory cytokine production in response to bacterial challenge were assessed in adolescents.
  
  
  RESULTS
  Our results suggest that SES moderates the detrimental effect of family chaos on systemic inflammation and interleukin-6 (B = -0.010, standard error [SE] = 0.004, p = .026), but not C-reactive protein (B = 0.009, SE = 0.006, p = .11), and on stimulated proinflammatory cytokine production (B = -0.098, SE = 0.044, p = .026) in adolescents, such that a chaotic family environment is positively associated with greater systemic inflammation and greater stimulated proinflammatory cytokine production in adolescents as family SES declines.
  
  
  CONCLUSIONS
  These findings indicate that living in chaotic family environments places youth who may be vulnerable based on socioeconomic factors at a potentially higher risk for inflammation-related diseases.
authors: From the Department of Pediatrics (H.M.C.S.), Icahn School of Medicine at Mount Sinai, New York, New York; Department of Psychology (L.B.R.), University of British Columbia, Vancouver, BC, Canada; Department of Psychiatry (L.T.F.), St Paul's Hospital, Vancouver, BC, Canada; and Department of Psychology and Cells to Society (C2S) (E.C.), The Center on Social Disparities and Health, Institute for Policy Research, Northwestern University, Evanston, Illinois.
authors: Hannah M C
authors: HM
authors: Schreier
authors: Laura B
authors: LB
authors: Roy
authors: Leora T
authors: LT
authors: Frimer
authors: Edith
authors: E
authors: Chen
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D016207:Cytokines / Q000097:blood*; D005195:Family Relations; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000209:etiology / Q000276:immunology; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D016487:Parenting / Q000523:psychology; D010641:Phenotype; D012923:Social Class
chemical_list: D015415:Biomarkers; D016207:Cytokines; D015850:Interleukin-6; D002097:C-Reactive Protein