title: Stand-alone ALIF with integrated intracorporeal anchoring plates in the treatment of degenerative lumbar disc disease: a prospective study on 65 cases.
abstract: OBJECTIVE
  ALIF with cages is expected to restore disc height and stabilize the spine promoting fusion, while avoiding damage attributed to rod-pedicle screw fixation. However, it may be related to an increased risk of fusion failure and subsidence. A prospective study was conducted by five investigators across three centers to confirm performance of a PEEK cage for stand-alone ALIF in the treatment of lumbar degenerative disc disease (DDD).
  
  
  METHODS
  Sixty-five patients, with back ± leg pain, requiring surgery for DDD, were included. Efficacy and safety were evaluated at 6 weeks, 3, 6, and 12 months post-operatively. Fusion and subsidence were assessed through CT-images at 12-month follow-up. Disc height was measured. Clinical outcomes included back and leg pain (VAS), disability (Oswestry Disability Index), Quality of Life (Short-Form 36), and adverse events.
  
  
  RESULTS
  The fusion and the subsidence rates were 96.3 and 2.0 %, respectively. ALIF surgery restored anterior and posterior disc height compared to baseline. There were no device-related serious adverse events, and no revision surgeries. Clinical outcomes improved significantly through 12-month follow-up.
  
  
  CONCLUSIONS
  Safety and efficacy of this stand-alone cage with integrated intracorporeal plates was confirmed through 12 months for treatment of degenerative conditions. The design of the cage and plates may contribute to the decreased subsidence rate observed.
authors: Department of Orthopedic Surgery, AP-HP, Henri Mondor University Hospital, Institut Du Rachis. Paris-Est University, Medical Faculty , Créteil 94000, France, jerome.allain@hmn.aphp.fr.
authors: Jérôme
authors: J
authors: Allain
authors: Joël
authors: J
authors: Delecrin
authors: Jacques
authors: J
authors: Beaurain
authors: Alexandre
authors: A
authors: Poignard
authors: Thierry
authors: T
authors: Vila
authors: Charles-Henri
authors: CH
authors: Flouzat-Lachaniette
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001860:Bone Plates; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D055959:Intervertebral Disc Degeneration / Q000601:surgery*; D007405:Intervertebral Disc Displacement / Q000601:surgery*; D017116:Low Back Pain / Q000601:surgery; D008159:Lumbar Vertebrae / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D011446:Prospective Studies; D011474:Prosthesis Design; D011788:Quality of Life; D020127:Recovery of Function; D013123:Spinal Fusion / Q000295:instrumentation* / Q000379:methods*; D059145:Total Disc Replacement / Q000295:instrumentation* / Q000379:methods*; D016896:Treatment Outcome