title: Changes in glucose disposal after a caloric restriction-induced weight loss program in obese postmenopausal women: characteristics of positive and negative responders in a Montreal-Ottawa New Emerging Team study.
abstract: OBJECTIVE
  This study aims to investigate individual characteristics that explain interindividual variations in glucose disposal in response to a 6-month weight loss program in obese postmenopausal women.
  
  
  METHODS
  The cohort was divided into tertiles based on changes in glucose disposal after weight loss. Only women in the upper tertile (positive responders: Δ glucose disposal ≥ 0.92 mg/kg/min; n = 19) and lower tertile (negative responders: Δ glucose disposal ≤ -0.23 mg/kg/min; n = 19) were considered for analyses. Outcome measures included body weight, lean body mass (LBM), LBM index (= LBM / height [m]), fat mass (FM), FM index (= FM / height [m]), visceral fat, subcutaneous abdominal fat, high-sensitivity C-reactive protein (hsCRP) levels, interleukin-6, lipid profile, physical activity levels, fasting blood glucose and insulin levels, glucose disposal by hyperinsulinemic-euglycemic clamp technique, and resting blood pressure.
  
  
  RESULTS
  At baseline, positive responders had higher triglycerides and hsCRP levels and lower glucose disposal (0.01 < P < 0.05) than negative responders. Except for visceral fat, the entire cohort showed significant decreases in all measures of body composition (P < 0.005) after weight loss, with greater decreases in body weight, body mass index, and FM index in positive responders (P < 0.005). Finally, data revealed that only positive responders showed decreases in LBM, LBM index, and hsCRP levels after weight loss (P between 0.01 and 0.001).
  
  
  CONCLUSIONS
  An important interindividual variability in changes in glucose disposal after weight loss is observed. Interestingly, participants who display improvements in glucose disposal also show significant decreases in LBM, LBM index, and hsCRP after weight loss.
authors: From the 1Faculty of Physical Education and Sport, Université de Sherbrooke, Sherbrooke, Québec, Canada; 2Centre de santé et de services sociaux, Institut universitaire de gériatrie de Sherbrooke, Sherbrooke, Québec, Canada; 3School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada; 4Institut de recherche de l'Hôpital Montfort, Ottawa, Ontario, Canada; 5Department of Nutrition, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada; 6Institut de Recherches Cliniques de Montréal, Montréal, Québec, Canada; and 7Department of Kinesiology, Université de Montréal, Montréal, Québec, Canada.
authors: Étienne
authors: É
authors: Myette-Côté
authors: Éric
authors: É
authors: Doucet
authors: Denis
authors: D
authors: Prud'homme
authors: Rémi
authors: R
authors: Rabasa-Lhoret
authors: Jean-Marc
authors: JM
authors: Lavoie
authors: Martin
authors: M
authors: Brochu
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D001823:Body Composition; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D031204:Caloric Restriction; D005260:Female; D015309:Glucose Clamp Technique; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology; D050152:Intra-Abdominal Fat; D008875:Middle Aged; D009765:Obesity / Q000178:diet therapy*; D017698:Postmenopause / Q000502:physiology*; D011792:Quebec; D014280:Triglycerides / Q000097:blood; D015431:Weight Loss / Q000502:physiology*; D061217:Weight Reduction Programs
chemical_list: D001786:Blood Glucose; D007328:Insulin; D014280:Triglycerides; D002097:C-Reactive Protein