title: Depression increases in patients with Parkinson?s disease according to the increasing severity of the cognitive impairment.
abstract: OBJECTIVE
  To test the hypothesis that severity of cognitive impairment modifies the association between depression and Parkinson's disease (PD).
  
  
  METHODS
  One-phase population-based door-to-door surveys. This is a secondary analysis of 1,451 people aged 65 years and older with cognitive impairment living in defined catchment areas. Depression was estimated according to ICD-10, self-reported PD, disability according to WHODAS-II and cognitive status according to the CSI-D.
  
  
  RESULTS
  The mean age of the sample was 79.3 years old and most (69%) were women. Of the total sample, 16.1% had depression and it was significantly higher among participants with PD. There was an increase on the ORs of the association between depression and PD with decreased scores in the cognitive test (Adjusted OR from 0.98 to 8.04).
  
  
  CONCLUSIONS
  The association between depression and PD increases with the severity of the cognitive impairment.
authors: Departamento de Neurociências e Ciências do Comportamento, Universidade de São Paulo, Ribeirao Preto, SP, Brazil.
authors: Marcos Hortes N
authors: MH
authors: Chagas
authors: Departamento de Psiquiatria, Laboratório Interdisciplinar de Neurociências Clínicas, Universidade Federal de São Paulo, Sao Paulo, SP, Brazil.
authors: Tais S
authors: TS
authors: Moriyama
authors: Instituto Israelita de Ensino e Pesquisa, Hospital Israelita Albert Einstein, Sao Paulo, SP, Brazil.
authors: André C
authors: AC
authors: Felício
authors: National Institute of Neurology and Neurosurgery of México, Mexico City, México.
authors: Ana Luisa
authors: AL
authors: Sosa
authors: Departamento de Psiquiatria, Laboratório Interdisciplinar de Neurociências Clínicas, Universidade Federal de São Paulo, Sao Paulo, SP, Brazil.
authors: Rodrigo A
authors: RA
authors: Bressan
authors: Departamento de Psicobiologia, Universidade Federal de São Paulo, Sao Paulo, SP, Brazil.
authors: Cleusa P
authors: CP
authors: Ferri
mesh_terms: D000369:Aged, 80 and over; D003072:Cognition Disorders / Q000503:physiopathology / Q000523:psychology*; D003866:Depressive Disorder / Q000209:etiology* / Q000503:physiopathology; D004522:Educational Status; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000503:physiopathology / Q000523:psychology*; D012720:Severity of Illness Index