title: Antifungal, anti-biofilm and adhesion activity of the essential oil of Myrtus communis L. against Candida species.
abstract: Candida species belong to the normal microbiota of the oral cavity, gastrointestinal tract and vagina. The increasing incidence of drug-resistant pathogens and the toxicity of the antifungal compounds have drawn the attention towards the antimicrobial activity of natural products, an inexpensive alternative. The aim of this work was to evaluate the adhesion activity, the biofilm formation and the action of the Myrtus communis L. essential oil (EO) on the biofilm formation towards three species isolated from clinical samples: Candida albicans, Candida parapsilosis and Candida tropicalis. Furthermore, we evaluated the antimycotic activity of the EO towards the three species, and the results were compared with the minimum inhibitory concentration of six antimycotics. The activity of the EO against C. albicans and C. parapsilosis was better than that obtained against C. tropicalis; moreover, the strains used in the assay were adhesive and biofilm producer, and the effect of myrtle EO on the biofilm formation yielded encouraging results.
authors: a Microbiologia Sperimentale e Clinica, Dipartimento di Scienze Biomediche , Università degli Studi di Sassari , Viale San Pietro 43/b, 07100 Sassari , Italy.
authors: Sara
authors: S
authors: Cannas
authors: Paola
authors: P
authors: Molicotti
authors: Donatella
authors: D
authors: Usai
authors: Andrea
authors: A
authors: Maxia
authors: Stefania
authors: S
authors: Zanetti
mesh_terms: D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects*; D002175:Candida / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D031651:Myrtus / Q000737:chemistry*; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D009822:Oils, Volatile
keywords: Candida spp; Myrtus communis L; adhesion; biofilm