title: Features of Epstein-Barr virus reactivation after allogeneic hematopoietic cell transplantation in Korean children living in an area of high seroprevalence against Epstein-Barr virus.
abstract: The present study was conducted to investigate Epstein-Barr virus (EBV) reactivation after hematopoietic cell transplantation (HCT) in Korean children living in an area of a high seroprevalence against EBV and to determine the impact of recipient age on EBV reactivation. Medical records of 248 children and adolescents who had received allogeneic HCT were retrospectively reviewed. The trends of EBV reactivation and post-transplant lymphoproliferative disorders (PTLDs) were evaluated and compared between younger (≤10 years old) and older (11-20 years old) groups. EBV reactivation occurred in 177 cases (71.4 %) and high-level EBV reactivation, defined as a virus DNA titer of 300,000 copies/mL or higher, occurred in 21 cases (8.5 %). PTLD was diagnosed in five cases (2.0 %), and one of these patients died. The EBV reactivation rate was not significantly different between the two age groups; however, high-level reactivation and PTLD were more significantly frequent in the older than in the younger group (P = 0.030 and P = 0.026, respectively). In conclusion, older children and adolescents are more likely to experience high-level EBV reactivation and PTLDs, and higher EBV DNA titers than those previously reported may be a predictor of PTLD in areas with a high seroprevalence against EBV.
authors: Department of Pediatrics, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul, 137-701, Republic of Korea.
authors: Seung Beom
authors: SB
authors: Han
authors: E Young
authors: EY
authors: Bae
authors: Jae Wook
authors: JW
authors: Lee
authors: Pil Sang
authors: PS
authors: Jang
authors: Dong-Gun
authors: DG
authors: Lee
authors: Nack-Gyun
authors: NG
authors: Chung
authors: Dae Chul
authors: DC
authors: Jeong
authors: Bin
authors: B
authors: Cho
authors: Soon Ju
authors: SJ
authors: Lee
authors: Jin Han
authors: JH
authors: Kang
authors: Hack-Ki
authors: HK
authors: Kim
mesh_terms: D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D020031:Epstein-Barr Virus Infections / Q000209:etiology / Q000473:pathology* / Q000821:virology; D005260:Female; D019337:Hematologic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D004854:Herpesvirus 4, Human / Q000472:pathogenicity / Q000502:physiology*; D006801:Humans; D007223:Infant; D008232:Lymphoproliferative Disorders / Q000209:etiology / Q000473:pathology* / Q000821:virology; D008297:Male; D012074:Remission Induction; D056910:Republic of Korea; D012189:Retrospective Studies; D016036:Seroepidemiologic Studies; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D019562:Viral Load; D014775:Virus Activation; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D000970:Antineoplastic Agents