title: Systemic regulation of mammalian ageing and longevity by brain sirtuins.
abstract: Sirtuins regulate numerous important biological processes in mammals, including various age-associated pathophysiologies. However, whether sirtuins are critical to control ageing and longevity in mammals has been controversial. Recent studies have demonstrated critical roles of sirtuins in the brain, especially the hypothalamus, in governing multiple physiological functions. These data provide strong evidence that brain sirtuins regulate mammalian ageing and longevity at the organismal level.
authors: Department of Developmental Biology, Washington University School of Medicine, Campus Box 8103, 660 South Euclid Avenue, St Louis, Missouri 63110, USA.
authors: Akiko
authors: A
authors: Satoh
authors: Department of Developmental Biology, Washington University School of Medicine, Campus Box 8103, 660 South Euclid Avenue, St Louis, Missouri 63110, USA.
authors: Shin-ichiro
authors: S
authors: Imai
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism; D003071:Cognition; D004644:Emotions; D004734:Energy Metabolism; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism*; D008136:Longevity; D051379:Mice; D055495:Neurogenesis; D051381:Rats; D037761:Sirtuins / Q000378:metabolism*
chemical_list: D037761:Sirtuins