title: Head and neck teratoma: from diagnosis to treatment.
abstract: BACKGROUND
  Head and neck teratoma is a rare entity. Its prognosis mostly depends on the risk of neonatal respiratory distress, its extension and potential malignancy. Surgical management must be as complete as possible to avoid recurrences and malignant transformation. The authors present a retrospective analysis of 6 cervicofacial teratomas and a review of the literature. The aim of the study was to analyse prenatal, neonatal and postnatal management of teratoma.
  
  
  METHODS
  Charts of children presenting with a head and neck teratoma, managed by our maxillofacial and plastic surgery unit, were analysed and antenatal, clinical, biological, radiological and pathological characteristics were collected. Surgical treatment, recurrences and surgical outcomes were analysed.
  
  
  RESULTS
  Six patients were included: 2 with a cervical teratoma, 2 with a facial teratoma and 2 with intraoral teratomas. In 2 cases, the lesions were diagnosed antenatally and both patients required neonatal resuscitation. All the patients underwent early surgery, and 3 with complete excisions. All patients with an initial incomplete excision eventually presented a recurrence and therefore second look surgery. No malignant transformation was noted.
  
  
  CONCLUSIONS
  Early prenatal diagnosis is crucial to neonatal care. Early surgery and meticulous follow-up are critical in the long-term favourable outcome.
authors: Service de Chirurgie Maxillofaciale et Plastique, Hôpital Necker Enfants Malades, APHP, 75015 Paris, France; Centre de Référence des Maladies Rares de la Cavité Buccale, MAFACE, 75015 Paris, France; INSERM, UMRS872, Equipe 5 Biologie Orale Moléculaire, 75006 Paris, France; Université Paris Descartes, 75006 Paris, France. Electronic address: natacha.kadlub@nck.aphp.fr.
authors: Natacha
authors: N
authors: Kadlub
authors: Service de Chirurgie Maxillofaciale et Plastique, Hôpital Necker Enfants Malades, APHP, 75015 Paris, France; Centre de Référence des Maladies Rares de la Cavité Buccale, MAFACE, 75015 Paris, France.
authors: Joseph
authors: J
authors: Touma
authors: Université Paris Descartes, 75006 Paris, France; Service d'ORL et Chirurgie Cervico-faciale, Hôpital Necker Enfants Malades, APHP, 75015 Paris, France.
authors: Nicolas
authors: N
authors: Leboulanger
authors: Service d'Imagerie Médicale, Hôpital d'Enfants Armand Trousseau, APHP, 75012 Paris, France.
authors: Catherine
authors: C
authors: Garel
authors: Service de Chirurgie Maxillofaciale et Plastique, Hôpital Necker Enfants Malades, APHP, 75015 Paris, France; Centre de Référence des Maladies Rares de la Cavité Buccale, MAFACE, 75015 Paris, France.
authors: Véronique
authors: V
authors: Soupre
authors: Service d'Anatomopathologie et cytologie, Hôpital d'Enfants Armand Trousseau, APHP, 75012 Paris, France; Université Pierre et Marie Curie, Faculté de Médecine Paris 6, 75005 Paris, France.
authors: Aurore Coulomb
authors: AC
authors: L'Herminé
authors: Service de Chirurgie Maxillofaciale et Plastique, Hôpital Necker Enfants Malades, APHP, 75015 Paris, France; Centre de Référence des Maladies Rares de la Cavité Buccale, MAFACE, 75015 Paris, France; INSERM, UMRS872, Equipe 5 Biologie Orale Moléculaire, 75006 Paris, France; Université Paris Descartes, 75006 Paris, France.
authors: Marie-Paule
authors: MP
authors: Vazquez
authors: Service de Chirurgie Maxillofaciale et Plastique, Hôpital Necker Enfants Malades, APHP, 75015 Paris, France; Centre de Référence des Maladies Rares de la Cavité Buccale, MAFACE, 75015 Paris, France; INSERM, UMRS872, Equipe 5 Biologie Orale Moléculaire, 75006 Paris, France; Université Pierre et Marie Curie, Faculté de Médecine Paris 6, 75005 Paris, France.
authors: Arnaud
authors: A
authors: Picard
mesh_terms: D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D005153:Facial Neoplasms / Q000151:congenital / Q000175:diagnosis / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D005865:Gestational Age; D006258:Head and Neck Neoplasms / Q000151:congenital / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009062:Mouth Neoplasms / Q000151:congenital / Q000175:diagnosis / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D011296:Prenatal Diagnosis / Q000379:methods; D012131:Respiratory Insufficiency / Q000175:diagnosis; D012189:Retrospective Studies; D024162:Second-Look Surgery; D013724:Teratoma / Q000151:congenital / Q000175:diagnosis* / Q000601:surgery; D016896:Treatment Outcome; D016216:Ultrasonography, Prenatal; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human; D000509:alpha-Fetoproteins
keywords: Benign teratoma; Cystic teratoma; Embryonic neoplasm; Germ cell neoplasm; Head and neck neoplasm; Mature teratoma