title: Relationship between polymorphisms in beta -2 adrenergic receptor gene and ischemic stroke in North Indian Population: a hospital based case control study.
abstract: BACKGROUND
  Stroke is a multi-factorial disease and influenced by both genetic and environmental factors. The purpose of the present case control study was to check the relationship between beta-2 adrenergic receptor (ADRB2) polymorphism and ischemic stroke in North Indian Population.
  
  
  METHODS
  In a hospital based case control study, patients with ischemic stroke and control subjects from outpatient department and neurology ward of All India Institute of Medical Sciences New Delhi. Genotyping was performed by using Polymerase chain reaction-Restriction fragment length polymorphism. Frequency distributions of genotypes and alleles were compared between cases and controls using multivariate logistic regression.
  
  
  RESULTS
  In this study, 224 patients and 224 age-and sex-matched control subjects were recruited. Mean age of cases and controls were 53.9 ± 13.4 and 53.6 ± 12.9 years respectively. Multivariate logistic regression analysis showed an independent association between Gln27Glu polymorphism and large vessel stroke (LVD) under a recessive model of inheritance (OR 3.9; 95% CI 1.3 to 11). An age-stratified analysis, suggested independent association between Gln27Glu polymorphism and ischemic stroke, large vessel disease and small vessel disease stroke who had onset of disease at an older age.
  
  
  CONCLUSIONS
  The findings of the present study suggest that Gln27Glu polymorphism of the ADRB2 gene may confer higher risk of large vessel disease stroke in a North Indian population. Prospective studies with larger sample size are required for independent validation.
authors: Department of Neurology, Room No, 704, Neurosciences Centre, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India. amits52003@gmail.com.
authors: Amit
authors: A
authors: Kumar
authors: Manjari
authors: M
authors: Tripathi
authors: Madakasira Vasantha Padma
authors: MV
authors: Srivastava
authors: Subbiah
authors: S
authors: Vivekanandhan
authors: Kameshwar
authors: K
authors: Prasad
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000483:Alleles; D002545:Brain Ischemia / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007194:India; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D011110:Polymorphism, Genetic; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*; D012306:Risk; D020521:Stroke / Q000235:genetics* / Q000473:pathology
chemical_list: C553443:ADRB2 protein, human; D018343:Receptors, Adrenergic, beta-2