title: Association between human leukocyte antigen-G 14-bp insertion/deletion polymorphism and cancer risk: a meta-analysis and systematic review.
abstract: BACKGROUND
  Human leukocyte antigen-G (HLA-G) is involved in the development and progression of human cancers, and numerous molecular epidemiological studies have been conducted to explore the potential relationship of HLA-G 14-bp insertion/deletion (ins/del) polymorphism with cancer risk. However, results from published studies were inconclusive.
  
  
  METHODS
  Both PUBMED and EMBASE databases were searched comprehensively to identify eligible studies investigating the association of HLA-G 14-bp ins/del polymorphism with cancer risk. Statistical analysis was performed by using STATA 12.0 and Review Manager 5.0.
  
  
  RESULTS
  Fourteen eligible studies with 2340 cancer patients and 3967 controls were included and analyzed with odds ratio (OR) and its corresponding 95% confidence interval (CI). Overall, no significant association between HLA-G 14-bp ins/del polymorphism and overall cancer risk was detected in all comparison models. Further subgroup analyses based on ethnicity and cancer types demonstrated the significant association among Asians (ins/del vs. del/del: OR = 0.80, 95% CI, 0.66-0.95; ins/ins+ins/del vs. del/del: OR = 0.80, 95% CI, 0.65-0.97) and for breast cancer (ins allele vs. del allele: OR = 0.76, 95% CI, 0.61-0.96; ins/ins vs. del/del: OR = 0.57, 95% CI, 0.37-0.87; and ins/ins vs. ins/del+del/del: OR = 0.60, 95% CI, 0.42-0.87).
  
  
  CONCLUSIONS
  This study suggested that HLA-G 14-bp ins/del polymorphism might contribute to breast cancer susceptibility and overall cancer risk among Asians. Further well-designed studies with larger sample size are warranted to validate our conclusion.
authors: Department of Urology, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, China.
authors: Yu-Zheng
authors: YZ
authors: Ge
authors: Department of Anesthesiology, JiangSu Armed Police General Hospital, 8 Jiangdu South Road, Yangzhou 225003, China.
authors: Qian
authors: Q
authors: Ge
authors: Department of Urology, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, China.
authors: Ming-Hao
authors: MH
authors: Li
authors: Department of Urology, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, China.
authors: Guo-Mei
authors: GM
authors: Shi
authors: Department of Radiation Oncology, JiangSu Armed Police General Hospital, 8 Jiangdu South Road, Yangzhou 225003, China.
authors: Xiao
authors: X
authors: Xu
authors: Department of Urology, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, China.
authors: Lu-Wei
authors: LW
authors: Xu
authors: Department of Urology, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, China.
authors: Zheng
authors: Z
authors: Xu
authors: Department of Urology, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, China.
authors: Tian-Ze
authors: TZ
authors: Lu
authors: Department of Urology, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, China.
authors: Ran
authors: R
authors: Wu
authors: Department of Urology, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, China.
authors: Liu-Hua
authors: LH
authors: Zhou
authors: Department of Urology, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, China.
authors: Jian-Ping
authors: JP
authors: Wu
authors: Department of Urology, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, China.
authors: Kai
authors: K
authors: Liang
authors: Department of Urology, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, China.
authors: Quan-Liang
authors: QL
authors: Dou
authors: Department of Urology, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, China.
authors: Jia-Geng
authors: JG
authors: Zhu
authors: Department of Urology, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, China.
authors: Wen-Cheng
authors: WC
authors: Li
authors: Department of Urology, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, China. Electronic address: urojiarp@126.com.
authors: Rui-Peng
authors: RP
authors: Jia
mesh_terms: D000483:Alleles; D044466:Asian People; D001943:Breast Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D059951:HLA-G Antigens / Q000235:genetics* / Q000276:immunology; D006801:Humans; D054643:INDEL Mutation; D008297:Male; D009369:Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012306:Risk
chemical_list: D059951:HLA-G Antigens
keywords: Cancer; Human leukocyte antigen-G; Meta-analysis; Polymorphism