title: Causes and pathophysiology of heart failure with preserved ejection fraction.
abstract: Heart failure with preserved ejection fraction (HFPEF) is frequently associated with multiple disorders complicating both the clinical management and the understanding of the underlying mechanisms. This review focuses on the causes and pathophysiology of HFPEF and overviews how cellular and molecular changes related to various comorbidities may influence the age-dependent and gender-dependent hemodynamic alterations of diastolic ventricular function.
authors: Division of Clinical Physiology, Faculty of Medicine, Institute of Cardiology, University of Debrecen, Móricz Zs. krt. 22, Debrecen 4032, Hungary.
authors: Árpád
authors: Á
authors: Kovács
authors: Division of Clinical Physiology, Faculty of Medicine, Institute of Cardiology, University of Debrecen, Móricz Zs. krt. 22, Debrecen 4032, Hungary. Electronic address: pappz@med.unideb.hu.
authors: Zoltán
authors: Z
authors: Papp
authors: Division of Clinical Physiology, Faculty of Medicine, Institute of Cardiology, University of Debrecen, Móricz Zs. krt. 22, Debrecen 4032, Hungary.
authors: László
authors: L
authors: Nagy
mesh_terms: D017677:Age Distribution; D000368:Aged; D001024:Aortic Valve Stenosis / Q000175:diagnosis / Q000453:epidemiology; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000503:physiopathology; D005260:Female; D006333:Heart Failure / Q000453:epidemiology* / Q000503:physiopathology*; D054144:Heart Failure, Diastolic / Q000453:epidemiology / Q000503:physiopathology; D054143:Heart Failure, Systolic / Q000453:epidemiology / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology / Q000503:physiopathology; D018384:Oxidative Stress / Q000502:physiology; D015995:Prevalence; D011379:Prognosis; D018570:Risk Assessment; D017678:Sex Distribution; D013318:Stroke Volume / Q000502:physiology*; D016019:Survival Analysis; D013577:Syndrome; D059289:Vascular Stiffness / Q000502:physiology*
keywords: Comorbidities; Exercise intolerance; Heart failure with preserved ejection fraction; Myocardial stiffness; Ventricular-arterial uncoupling