title: Applications of RNA interference high-throughput screening technology in cancer biology and virology.
abstract: RNA interference (RNAi) is an ancient intra-cellular mechanism that regulates gene expression and cell function. Large-scale gene silencing using RNAi high-throughput screening (HTS) has opened an exciting frontier to systematically study gene function in mammalian cells. This approach enables researchers to identify gene function in a given biological context and will provide considerable novel insight. Here, we review RNAi HTS strategies and applications using case studies in cancer biology and virology.
authors: Department of Oncology, John Radcliffe Hospital, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, UK, shan.gao@oncology.ox.ac.uk.
authors: Shan
authors: S
authors: Gao
authors: Chen
authors: C
authors: Yang
authors: Shan
authors: S
authors: Jiang
authors: Xiao-Ning
authors: XN
authors: Xu
authors: Xin
authors: X
authors: Lu
authors: You-Wen
authors: YW
authors: He
authors: Annie
authors: A
authors: Cheung
authors: Hui
authors: H
authors: Wang
mesh_terms: D000818:Animals; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods / Q000639:trends; D009369:Neoplasms / Q000235:genetics* / Q000628:therapy; D034622:RNA Interference; D014764:Viral Proteins / Q000235:genetics; D014777:Virus Diseases / Q000235:genetics* / Q000628:therapy / Q000821:virology
chemical_list: D014764:Viral Proteins