title: Chromatographycally efficient microspherical composites of molecularly imprinted xerogels deposited inside mesoporous silica.
abstract: A different approach to the preparation of microspheric particles of molecularly imprinted xerogels (MIX) is presented here. The technique consisted of filling up the pores of spherical, mesoporous, bare silica particles with a pregelification mixture by applying pressure. Upon gelification and drying, thin layers of MIX were deposited on the mesopores. Spherical composites of S-naproxen (S-NAP) imprints were produced by following this simple strategy. The performance of the imprints was quite satisfactory in terms of recognition ability (ascertained by selectivity against ibuprofen, α=4.9, and an imprinting factor of 13) whereas an outstanding improvement on dynamic features (expressed as column efficiency), as compared to the corresponding bulk format MIX (9 vs. 1.2 theoretical plates/cm), was reached.
authors: Centro de Investigação em Química and Faculdade de Ciências, University of Porto, 4169 007 Porto, Portugal. Electronic address: porkodikathirvel@yahoo.com.
authors: Porkodi
authors: P
authors: Kadhirvel
authors: Centro de Investigação em Química and Faculdade de Ciências, University of Porto, 4169 007 Porto, Portugal. Electronic address: mazenha@fc.up.pt.
authors: Manuel
authors: M
authors: Azenha
authors: Centro de Investigação em Química and Faculdade de Ciências, University of Porto, 4169 007 Porto, Portugal.
authors: A Fernando
authors: AF
authors: Silva
authors: INFU, Faculty of Chemistry, Technical University of Dortmund, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany; Department of Biomedical Sciences, Faculty of Health and Society, Malmö University, Malmö högskola, 205 06 Malmö, Sweden.
authors: Börje
authors: B
authors: Sellergren
mesh_terms: D005782:Gels / Q000737:chemistry; D007052:Ibuprofen / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D054802:Molecular Imprinting / Q000379:methods*; D009288:Naproxen / Q000737:chemistry; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D005782:Gels; D009288:Naproxen; D012822:Silicon Dioxide; D007052:Ibuprofen
keywords: Column efficiency; Frontal analysis; Microspherical silica; Molecular imprinting; Naproxen; Sol–gel