title: Modification of Microbial Polymalic Acid With Hydrophobic Amino Acids for Drug-Releasing Nanoparticles.
abstract: Microbial poly(β, l-malic acid) was modified with either l-leucine ethyl ester (L) or l-phenylalanine methyl ester (F) to produce amphiphylic copolymers. The degradation of these copolymers in aqueous buffer took place under physiological conditions in a few weeks by hydrolysis of the side chain ester group followed by cleavage of the main chain. Spherical nanoparticles with diameters ranging between 70 and 230 nm were prepared from these copolymers by the dialysis-precipitation method. No alteration of the cell viability was observed after incubation of these nanoparticles in different cell lines. Anticancer drugs temozolomide and doxorubicin were encapsulated in the nanoparticles. Temozolomide was released within several hours whereas doxorubicin took several weeks to be completely liberated.
authors: Departament d'Enginyeria Química, Universitat Politècnica de Catalunya, ETSEIB, Diagonal 647, 08028, Barcelona, Spain.
authors: Alberto
authors: A
authors: Lanz-Landázuri
authors: Departament d'Enginyeria Química, Universitat Politècnica de Catalunya, ETSEIB, Diagonal 647, 08028, Barcelona, Spain.
authors: Montserrat
authors: M
authors: García-Alvarez
authors: Department of Neurosurgery, Cedars-Sinai Medical Center, 8631 W Third Street, Suite 800E, Los Angeles, CA 90048, USA.
authors: José
authors: J
authors: Portilla-Arias
authors: Departament d'Enginyeria Química, Universitat Politècnica de Catalunya, ETSEIB, Diagonal 647, 08028, Barcelona, Spain.
authors: Antxon Martínez
authors: AM
authors: de Ilarduya
authors: Department of Neurosurgery, Cedars-Sinai Medical Center, 8631 W Third Street, Suite 800E, Los Angeles, CA 90048, USA.
authors: Eggehard
authors: E
authors: Holler
authors: Department of Neurosurgery, Cedars-Sinai Medical Center, 8631 W Third Street, Suite 800E, Los Angeles, CA 90048, USA.
authors: Julia
authors: J
authors: Ljubimova
authors: Departament d'Enginyeria Química, Universitat Politècnica de Catalunya, ETSEIB, Diagonal 647, 08028, Barcelona, Spain.
authors: Sebastián
authors: S
authors: Muñoz-Guerra
keywords: anticancer; biodegradable nanoparticles; drug delivery system; poly(malic acid); polymalates