title: Comparison of cystatin-C and pentraxin-3 in coronary atherosclerosis.
abstract: OBJECTIVE
  Inflammation is one of the numerous factors that promote atherosclerosis. Cystatin-C (Cys-C) and pentraxin-3 (PTX-3) predominantly play roles in inflammation. Thus, we evaluated whether these markers were related to the presence and severity of coronary artery disease (CAD).
  
  
  METHODS
  Eighty-two stable patients who had undergone coronary angiography were enrolled in the study. Patients were diagnosed with significant (>50% stenosis) and nonsignificant (<50% stenosis) CAD. Patients with diabetes, chronic heart failure, chronic kidney disease, and so on were excluded from the study.
  
  
  RESULTS
  Patients without CAD had higher Cys-C levels compared with those with CAD (1338.96±396.71 vs. 853.69±406.72 ng/ml, P<0.001). However, the PTX-3 level was inversely lower in patients without CAD (110.40±48.10 vs. 149.46±49.44 pg/ml, P=0.001). The Cys-C level was found to be 677.11±335.56, 1024.18±401.21, and 1338.96±396.71 ng/ml in patients with significant CAD and nonsignificant CAD, and healthy individuals, respectively (P<0.001). The PTX-3 level was inversely reduced in these groups: 168.43±49.09, 131.14±43.10, and 110.40±48.10 pg/ml, respectively (P<0.001).
  
  
  CONCLUSIONS
  We observed that the levels of Cys-C and PTX-3 were inversely varied in the same study groups. These parameters may aid detection of the presence or identification of the severity of CAD when used in combination. Determinative values could exactly be described in the large study groups.
authors: aDepartment of Family Medicine, Mayo Clinic, Rochester, Minnesota, USA bDepartment of Family Medicine cDepartment of Cardiology dDepartment of Biochemistry, Gulhane Military Medical Faculty eDepartment of Cardiology, Etimesgut Military Hospital, Ankara fBalmumcu Family Health Center, Gumussuyu Military Hospital, Istanbul, Turkey.
authors: Yusuf C
authors: YC
authors: Doganer
authors: Umit
authors: U
authors: Aydogan
authors: Mustafa
authors: M
authors: Aparci
authors: Polat
authors: P
authors: Nerkiz
authors: Cem
authors: C
authors: Barcin
authors: Tuncer
authors: T
authors: Cayci
authors: Oktay
authors: O
authors: Sari
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000378:metabolism*; D023921:Coronary Stenosis / Q000000981:diagnostic imaging / Q000378:metabolism*; D055316:Cystatin C / Q000378:metabolism*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D012720:Severity of Illness Index; D000099153:Pentraxins
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D055316:Cystatin C; D000683:Serum Amyloid P-Component; D000099153:Pentraxins; C525030:CST3 protein, human