title: [Laboratory diagnostics of ANCA-vasculitis].
abstract: The antineutrophil cytoplasmic antibody (ANCA) are associated with distinct forms of primary small vessel vasculitides, collectively reffered to as ANCA-associated vasculitis (AAV). ANCA were originally identified by IIF. Importantly, however, only ANCA directed to PR3 (PR3-ANCA) or MPO (MPO-ANCA) are relevant for the diagnosis AAV, there is international consensus that ANCA should be detected by a combination of IIF and antigen-specific assays, i.e. detection of PR3 and MPO-ANCA. Several novel technologies have become available for antigen-specific ANCA detection.
authors: Ilza
authors: I
authors: Salamunić
authors: Dusanka Martinović
authors: DM
authors: Kaliterna
mesh_terms: D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000175:diagnosis*; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis*; D015415:Biomarkers / Q000097:blood; D019411:Clinical Laboratory Techniques; D006801:Humans
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D015415:Biomarkers