title: Induction of apoptosis by a peptide from Porphyra yezoensis: regulation of the insulin-like growth factor I receptor signaling pathway in MCF-7 cells.
abstract: This study examined how PPY, a peptide from Porphyra yezoensis, regulates multiple cell growth-related signaling pathways in MCF-7 cells. This study determined that PPY induces cell cycle arrest and inhibits the IGF-IR signaling pathway. Cell proliferation studies revealed that PPY induced cell death in a dose-dependent manner. Expression levels of IGF-IR were decreased in MCF-7 cells by PPY in a dose‑dependent manner. These results indicate that inhibition of the IGF-IR pathway is also involved in PPY induced proliferation of MCF-7 cells. In addition, these data demonstrated that PPY induces cell cycle arrest and activates apoptosis.
authors: Department of Food and Science, Pukyong National University, Busan 608-737, Republic of Korea.
authors: Su-Jin
authors: SJ
authors: Park
authors: Department of Food and Science, Pukyong National University, Busan 608-737, Republic of Korea.
authors: Jina
authors: J
authors: Ryu
authors: Institute of Fisheries Science, Pukyong National University, Busan 619-911, Republic of Korea.
authors: In-Hye
authors: IH
authors: Kim
authors: Institute of Fisheries Science, Pukyong National University, Busan 619-911, Republic of Korea.
authors: Youn-Hee
authors: YH
authors: Choi
authors: Department of Food and Science, Pukyong National University, Busan 608-737, Republic of Korea.
authors: Taek-Jeong
authors: TJ
authors: Nam
mesh_terms: D017209:Apoptosis; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D002453:Cell Cycle / Q000187:drug effects; D059447:Cell Cycle Checkpoints; D004305:Dose-Response Relationship, Drug; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D061986:MCF-7 Cells; D010455:Peptides / Q000138:chemical synthesis / Q000494:pharmacology*; D010940:Plant Proteins / Q000494:pharmacology*; D044664:Porphyra / Q000737:chemistry*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: C000595296:PPY peptide, Porphyra yezoensis; D010455:Peptides; D010940:Plant Proteins