title: Risk of polio reintroduction to border regions of Islamic Republic of Iran: seroprevalence study of children with at least 5 doses of oral polio vaccine.
abstract: Movements of populations from countries where polio has not been eradicated is a concern in the Islamic Republic of Iran. A cross-sectional, community-based study was implemented in 2010 in 2 districts in Sistan-va-Baluchestan Province near the south-east border. The aim was to determine the seroprevalence of antibodies in children aged 20 (± 2) months who had received at least 5 doses of trivalent oral polio vaccine. Using cluster sampling, 365 children were enrolled for serological testing. Antibody titres ≥ 1:10 were considered positive. Seropositive rates for antibody against poliovirus serotypes 1, 2 and 3 were 94.1%, 96.7% and 78.3% respectively. The lowest seropositive rate was for antibody against polio serotype 3 (PV3) among boys (58.3%). Exclusive breastfeeding showed a direct relationship with antibody response to PV3 (OR = 2.0; 95% CI: 1.1-3.6). Improving community protection against PV3 is an urgent programme priority.
authors: Health Promotion Research Centre, School of Public Health, Zahedan University of Medical Sciences, Zahedan, Islamic Republic of Iran.
authors: S
authors: S
authors: Izadi
authors: Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
authors: S
authors: S
authors: Shahmahmoodi
authors: Centre for Communicable Disease Control, Ministry of Health and Medical Education, Tehran, Islamic Republic of Iran.
authors: S M
authors: SM
authors: Zahraei
authors: Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
authors: F
authors: F
authors: Dorostkar
authors: Department of Epidemiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
authors: R
authors: R
authors: Majdzadeh
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D001942:Breast Feeding; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007223:Infant; D007492:Iran / Q000453:epidemiology; D007514:Islam; D008297:Male; D011051:Poliomyelitis / Q000453:epidemiology / Q000517:prevention & control*; D011055:Poliovirus Vaccine, Oral / Q000008:administration & dosage*; D012306:Risk; D016036:Seroepidemiologic Studies; D011795:Surveys and Questionnaires
chemical_list: D000914:Antibodies, Viral; D011055:Poliovirus Vaccine, Oral