title: A convenient four-component one-pot synthesis of 2-amino-1,3,4-thiadiazoles in water.
abstract: A novel four-component one-pot approach for the synthesis of 2-amino-1,3,4-thiadiazoles from primary amines, carbon disulfide, hydrazine, and acyl chlorides has been developed. A series of 5-substituted-2-amino-1,3,4-thiadiazoles were synthesized in medium-to-good yields utilizing this newly developed method.
authors: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing , 100191, People's Republic of China.
authors: Peng
authors: P
authors: Liu
authors: Ao-Ze
authors: AZ
authors: Su
authors: Yuan-Qiang
authors: YQ
authors: Wang
authors: Ze-Mei
authors: ZM
authors: Ge
authors: Tie-Ming
authors: TM
authors: Cheng
authors: Run-Tao
authors: RT
authors: Li
mesh_terms: D060326:Chemistry Techniques, Synthetic; D013830:Thiadiazoles / Q000138:chemical synthesis*; D014867:Water / Q000737:chemistry*
chemical_list: D013830:Thiadiazoles; D014867:Water; C010852:2-amino-1,3,4-thiadiazole