title: HLA-G gene polymorphisms associated with susceptibility to rheumatoid arthritis disease and its severity in Brazilian patients.
abstract: We analyzed the possible association between human leukocyte antigen-G (HLA-G) genetic variants, supposed to regulate HLA-G expression, and the susceptibility to develop rheumatoid arthritis (RA) as well as its clinical manifestations. The 5'upstream regulatory region (5'URR) and 3'untranslated region (3'UTR) regions of the HLA-G gene were screened in 127 RA patients and 128 controls: 10 5'URR and 3 3'UTR HLA-G polymorphisms as well as two haplotypes were associated with risk for RA development, while a polymorphism in the 5'URR showed an association with the degree of disease activity. These findings, although the number of cases analyzed is limited and the P-values are modest, indicate a possible association between HLA-G gene polymorphisms and susceptibility to develop RA disease and its severity.
authors: Department of Life Sciences, University of Trieste, Trieste, Italy.
authors: E
authors: E
authors: Catamo
authors: C
authors: C
authors: Addobbati
authors: L
authors: L
authors: Segat
authors: T
authors: T
authors: Sotero Fragoso
authors: A
authors: A
authors: Domingues Barbosa
authors: A
authors: A
authors: Tavares Dantas
authors: H
authors: H
authors: de Ataíde Mariz
authors: L
authors: L
authors: F da Rocha
authors: A L
authors: AL
authors: Branco Pinto Duarte
authors: L
authors: L
authors: Monasta
authors: P
authors: P
authors: Sandrin-Garcia
authors: S
authors: S
authors: Crovella
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics; D024506:5' Flanking Region / Q000235:genetics; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000276:immunology*; D001938:Brazil; D004252:DNA Mutational Analysis; D018450:Disease Progression; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D059951:HLA-G Antigens / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012306:Risk
chemical_list: D020413:3' Untranslated Regions; D059951:HLA-G Antigens
keywords: Brazilian patients; genetic polymorphisms; human leukocyte antigen-G; mRNA instability; rheumatoid arthritis