title: End-of-study results of Turkish gastric cancer patients from the global REGATE study.
abstract: OBJECTIVE
  Registry of Gastric Cancer Treatment Evaluation (REGATE) study was an international, prospective study including over 10000 patients from 22 countries, designed to describe the pattern of care in gastric cancer globally. The aim of this study was to summarize the data of the Turkish arm and compare them with the global results.
  
  
  METHODS
  Ten centers from Turkey took part in the REGATE registry. Between 2004 and 2008, 395 patients (median age, 60 years; range, 18-91, 67.6% men) with newly diagnosed primary adenocarcinoma of the stomach were followed at initial visit and 8-10 months later, at the time of treatment completion. Data on patient demographics, medical history, histopathology, cancer stage, planned and realized treatments was prospectively collected. Data processing and analysis were conducted centrally.
  
  
  RESULTS
  In Turkey, the majority of patients were diagnosed at an advanced stage, while the rate of surgery was lesser compared with the rest of the world. Realized treatment included more palliative-only therapy than initially planned (63.3%), while no therapy was recommended in 21.8%. Surgery involved total gastrectomy (46.3%) or distal subtotal gastrectomy (51.9%), with 87% R0 resection, 51.0% D1 and 44.9% D2 lymph node dissection. Combination chemotherapy was administered in more than half of the patients receiving palliative therapy (57.9%). Chemoradiotherapy was used in 66.7% of the cases receiving adjuvant therapy. Radiotherapy was applied to 32% of the cases receiving palliative therapy.
  
  
  CONCLUSIONS
  Advanced stage gastric cancer is highly prevalent in Turkey. Increasing public awareness and implementing screening programs in high risk groups may help identify gastric cancer at earlier stages.
authors: Hacettepe University Institute of Oncology, Ankara, Turkey.
authors: Suayib
authors: S
authors: Yalcin
authors: Mahmut
authors: M
authors: Gumus
authors: Saadettin
authors: S
authors: Kilickap
authors: Necati
authors: N
authors: Alkis
authors: Mahmut
authors: M
authors: Ilhan
authors: Berna
authors: B
authors: Oksuzoglu
authors: Bulent
authors: B
authors: Orhan
authors: Mustafa
authors: M
authors: Unsal
authors: Salim
authors: S
authors: Basol Tekin
authors: Bulent
authors: B
authors: Yalcin
authors: Gokhan
authors: G
authors: Demir
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010166:Palliative Care; D011446:Prospective Studies; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D014421:Turkey