title: Associations between a history of binge drinking during adolescence and self-reported responses to alcohol in young adult Native and Mexican Americans.
abstract: BACKGROUND
  Binge drinking during adolescence is common and may predict increased drinking in young adulthood and enhanced risk of alcohol dependence. Variation in level of response to the hedonic and adverse effects of alcohol is in part an inherited factor that may also influence its use, abuse, and dependence. This study investigated, in young adults, whether an association could be demonstrated between variation in self-reported responses to alcohol and a history of binge drinking during adolescence.
  
  
  METHODS
  Young adult (18 to 30 years, n = 790) Native Americans and Mexican Americans were recruited from the community and completed a structured diagnostic interview. Response to alcohol was indexed using the expectation version of the Subjective High Assessment Scale (SHAS-E). An adolescent history of regular binge drinking was defined as drinking 5 or more drinks for boys and 4 or more drinks for girls per drinking occasion at least once a month during their highest drinking period prior to the age of 18.
  
  
  RESULTS
  An adolescent history of regular binge drinking was found to be associated with a lower level of self-reported responses to the negative aspects of alcohol intoxication (feeling terrible) as well as to the overall level of intoxication, but not to the positive impressions of intoxication (feeling great) on the SHAS-E. A history of regular adolescent binge drinking was also correlated with less feelings of the "terrible" and "total" effects of alcohol, as indexed by the SHAS-E, in a linear regression model that included several diagnostic and demographic variables such as a history of conduct disorder and current levels of drinking.
  
  
  CONCLUSIONS
  These data suggest that a history of adolescent binge drinking is associated with a reduction in the self-reported level of intoxication in young adulthood, a factor that could theoretically lead to increased risk of alcohol dependence.
authors: Department of Molecular and Cellular Neurosciences, The Scripps Research Institute, La Jolla, California.
authors: Cindy L
authors: CL
authors: Ehlers
authors: Gina M
authors: GM
authors: Stouffer
authors: David A
authors: DA
authors: Gilder
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior / Q000523:psychology*; D000328:Adult; D000435:Alcoholic Intoxication / Q000523:psychology; D063425:Binge Drinking / Q000523:psychology*; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D007198:Indians, North American / Q000523:psychology*; D008297:Male; D017058:Mexican Americans / Q000523:psychology*; D057566:Self Report; D055815:Young Adult
keywords: Adolescence; Alcohol; Binge Drinking; Mexican Americans; Native Americans