title: Steroid receptor coactivators: servants and masters for control of systems metabolism.
abstract: Coregulator recruitment to nuclear receptors (NRs) and other transcription factors is essential for proper metabolic gene regulation, with coactivators enhancing and corepressors attenuating gene transcription. The steroid receptor coactivator (SRC) family is composed of three homologous members (SRC-1, SRC-2, and SRC-3), which are uniquely important for mediating steroid hormone and mitogenic actions. An accumulating body of work highlights the diverse array of metabolic functions regulated by the SRCs, including systemic metabolite homeostasis, inflammation, and energy regulation. We discuss here the cooperative and unique functions among the SRCs to provide a comprehensive atlas of systemic SRC metabolic regulation. Deciphering the fractional and synergistic contributions of the SRCs to metabolic homeostasis is crucial to understanding fully the networks underlying metabolic transcriptional regulation.
authors: Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
authors: Erin
authors: E
authors: Stashi
authors: Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
authors: Brian
authors: B
authors: York
authors: Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA. Electronic address: berto@bcm.edu.
authors: Bert W
authors: BW
authors: O'Malley
mesh_terms: D000818:Animals; D006801:Humans; D056920:Nuclear Receptor Coactivator 1 / Q000378:metabolism*; D051958:Nuclear Receptor Coactivator 2 / Q000378:metabolism*; D056921:Nuclear Receptor Coactivator 3 / Q000378:metabolism*
chemical_list: D051958:Nuclear Receptor Coactivator 2; D056920:Nuclear Receptor Coactivator 1; D056921:Nuclear Receptor Coactivator 3
keywords: coregulator; metabolism; nuclear receptor; steroid receptor coactivator; transcription