title: Influence of immune responses in gene/stem cell therapies for muscular dystrophies.
abstract: Muscular dystrophies (MDs) are a heterogeneous group of diseases, caused by mutations in different components of sarcolemma, extracellular matrix, or enzymes. Inflammation and innate or adaptive immune response activation are prominent features of MDs. Various therapies under development are directed toward rescuing the dystrophic muscle damage using gene transfer or cell therapy. Here we discussed current knowledge about involvement of immune system responses to experimental therapies in MDs.
authors: Laboratorio Cellule Staminali, Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Centro Dino Ferrari, Via F. Sforza 35, 20122 Milano, Italy.
authors: Andrea
authors: 0000-0002-8514-4921
authors: A
authors: Farini
authors: Laboratorio Cellule Staminali, Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Centro Dino Ferrari, Via F. Sforza 35, 20122 Milano, Italy.
authors: Clementina
authors: C
authors: Sitzia
authors: Ystem s.r.l., Via Podgora 7, 20122 Milano, Italy.
authors: Silvia
authors: S
authors: Erratico
authors: Laboratorio Cellule Staminali, Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Centro Dino Ferrari, Via F. Sforza 35, 20122 Milano, Italy.
authors: Mirella
authors: 0000-0002-5151-607X
authors: M
authors: Meregalli
authors: Laboratorio Cellule Staminali, Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Centro Dino Ferrari, Via F. Sforza 35, 20122 Milano, Italy.
authors: Yvan
authors: Y
authors: Torrente
mesh_terms: D064987:Cell- and Tissue-Based Therapy; D005109:Extracellular Matrix / Q000276:immunology / Q000378:metabolism; D015316:Genetic Therapy; D006801:Humans; D007113:Immunity, Innate; D009136:Muscular Dystrophies / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D009154:Mutation; D013234:Stem Cells / Q000166:cytology / Q000276:immunology*