title: Reorganization of large-scale cognitive networks during automation of imagination of a complex sequential movement.
abstract: We investigated the functional reconfiguration of the cerebral networks involved in imagination of sequential movements of the left foot, both performed at regular and fast speed after mental imagery training. Thirty-five volunteers were scanned with a 3T MRI while they imagined a sequence of ankle movements (dorsiflexion, plantar flexion, varus and valgus) before and after mental practice. Subjects were distributed in two groups: the first group executed regular movements whereas the second group made fast movements. We applied the general linear model (GLM) and model-free, exploratory tensorial independent component analytic (TICA) approaches to identify plastic post-training effects on brain activation. GLM showed that post-training imagination of movement was accompanied by a dual effect: a specific recruitment of a medial prefronto-cingulo-parietal circuit reminiscent of the default-mode network, with the left putamen, and a decreased activity of a lateral fronto-parietal network. Training-related subcortical changes only consisted in an increased activity in the left striatum. Unexpectedly, no difference was observed in the cerebellum. TICA also revealed involvement of the left executive network, and of the dorsal control executive network but no significant differences were found between pre- and post-training phases. Therefore, repetitive motor mental imagery induced specific putamen (motor rehearsal) recruitment that one previously observed during learning of overt movements, and, simultaneously, a specific shift of activity from the dorsolateral prefrontal cortex (attention, working memory) to the medial posterior parietal and cingulate cortices (mental imagery and memory rehearsal). Our data complement and confirm the notion that differential and coupled recruitment of cognitive networks can constitute a neural marker of training effects.
authors: Service de Neurologie et Neurorevalidation, Hôpital Erasme, ULB, Bruxelles, Belgium.
authors: C
authors: C
authors: Sauvage
authors: Service de Neurologie et Neurorevalidation, Hôpital Erasme, ULB, Bruxelles, Belgium.
authors: N
authors: N
authors: De Greef
authors: Unité d'Etude du Mouvement, FNRS, ULB-Erasme, Belgium.
authors: M
authors: M
authors: Manto
authors: Service de Neuroradiologie, Hôpital Erasme, ULB, Bruxelles, Belgium.
authors: P
authors: P
authors: Jissendi
authors: Service de NeuroImagerie, hôpital du Val-de-Grâce, Paris, France.
authors: C
authors: C
authors: Nioche
authors: Service de NeuroImagerie, CHNO des Quinze-Vingts, UPMC Paris 6, 75012 Paris, France. Electronic address: chabas@quinze-vingts.fr.
authors: C
authors: C
authors: Habas
mesh_terms: D000328:Adult; D001288:Attention / Q000502:physiology; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods; D003071:Cognition / Q000502:physiology*; D005260:Female; D006801:Humans; D007092:Imagination / Q000502:physiology*; D008297:Male; D009068:Movement / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013647:Task Performance and Analysis
keywords: Basal ganglia; Cerebellum; Executive control network; Mental practice; Motor imagery; Training; Velocity; fMRI