title: Pharmacological treatments in gambling disorder: a qualitative review.
abstract: Gambling disorder (GD) is a psychiatric condition associated with both social and family costs; DSM-5 currently includes GD among addictive disorders. Despite the high burden of this condition, to date there are no treatment guidelines approved by Food and Drug Administration (FDA). Purpose of this paper is to offer a qualitative overview about the different pharmacologic agents used for the treatment of GD. Our analysis, conducted on a final selection of 75 scientific papers, demonstrates that a variety of pharmaceutical classes have been utilised, with different results. Published data, although limited by brief duration of the studies and small number of enrolled subjects, shows mixed evidence for serotonergic antidepressants, opioid antagonists, and mood stabilizers. Other compounds, such as glutamatergic agents and psychostimulants, deserve further studies.
authors: Department of Neuroscience and Imaging, University "G. d'Annunzio", Chieti, Italy.
authors: Matteo
authors: M
authors: Lupi
authors: Department of Neuroscience and Imaging, University "G. d'Annunzio", Chieti, Italy.
authors: Giovanni
authors: G
authors: Martinotti
authors: Department of Neuroscience and Imaging, University "G. d'Annunzio", Chieti, Italy.
authors: Tiziano
authors: T
authors: Acciavatti
authors: Department of Psychiatry, Drug Addiction Unit, Catholic University Medical School, Rome, Italy.
authors: Mauro
authors: 0000-0002-4164-3040
authors: M
authors: Pettorruso
authors: Department of Neuroscience and Imaging, University "G. d'Annunzio", Chieti, Italy.
authors: Marcella
authors: M
authors: Brunetti
authors: Department of Neuroscience and Imaging, University "G. d'Annunzio", Chieti, Italy.
authors: Rita
authors: 0000-0003-1377-9183
authors: R
authors: Santacroce
authors: Department of Neuroscience and Imaging, University "G. d'Annunzio", Chieti, Italy.
authors: Eduardo
authors: E
authors: Cinosi
authors: Department of Neuroscience and Imaging, University "G. d'Annunzio", Chieti, Italy.
authors: Giuseppe
authors: G
authors: Di Iorio
authors: Department of Psychiatry, Drug Addiction Unit, Catholic University Medical School, Rome, Italy.
authors: Marco
authors: M
authors: Di Nicola
authors: Department of Neuroscience and Imaging, University "G. d'Annunzio", Chieti, Italy.
authors: Massimo
authors: M
authors: Di Giannantonio
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use; D016739:Behavior, Addictive / Q000188:drug therapy* / Q000503:physiopathology; D018683:Excitatory Amino Acid Agents / Q000627:therapeutic use*; D005715:Gambling / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D014481:United States; D014486:United States Food and Drug Administration
chemical_list: D014150:Antipsychotic Agents; D018683:Excitatory Amino Acid Agents