title: Most frequent molecular and immunohistochemical markers present in selected types of brain tumors.
abstract: Tumors of brain tissue and meninges create a heterogeneous group with various biological behavior, therapy management and differing prognosis. Some of these do not require treatment, some can be cured by surgery and some are rapidly fatal despite treatment. Despite huge progress in tumor research, innovations in diagnostic tools and therapy, prognosis remains, in case of malignant tumor types, very serious. There has been an increased understanding of molecular abnormalities occurring in primary brain tumors. Genome-wide analyses of tumors have improved the knowledge in tumor biology. The aim of the research is to explain the oncogenesis features thus leading to the use of new therapeutic modalities in order to prolong survival rate of patients and at the same time providing satisfactory life quality. This article offers a short review of the basic genetic alterations present with some histological types of brain tumors.
authors: Department of Medical Biochemistry, Comenius University Bratislava, Jessenius Faculty of Medicine, Malá hora 4, Martin, Slovak Republic. romana.richterova@gmail.com.
authors: Romana
authors: R
authors: Richterová
authors: Jana
authors: J
authors: Jurečeková
authors: Andrea
authors: A
authors: Evinová
authors: Branislav
authors: B
authors: Kolarovszki
authors: Martin
authors: M
authors: Benčo
authors: Július
authors: J
authors: De Riggo
authors: Juraj
authors: J
authors: Sutovský
authors: Silvia
authors: S
authors: Mahmood
authors: Peter
authors: P
authors: Račay
authors: Dušan
authors: D
authors: Dobrota
mesh_terms: D001254:Astrocytoma / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism*; D004806:Ependymoma / Q000378:metabolism; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D055106:Genome-Wide Association Study; D005910:Glioma / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008223:Lymphoma / Q000378:metabolism; D008527:Medulloblastoma / Q000378:metabolism; D008577:Meningeal Neoplasms / Q000378:metabolism; D008579:Meningioma / Q000378:metabolism; D009837:Oligodendroglioma / Q000378:metabolism; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor