title: J-aggregates of organic dye molecules complexed with iron oxide nanoparticles for imaging-guided photothermal therapy under 915-nm light.
abstract: Recently, the development of nano-theranostic agents aiming at imaging guided therapy has received great attention. In this work, a near-infrared (NIR) heptamethine indocyanine dye, IR825, in the presence of cationic polymer, polyallylamine hydrochloride (PAH), forms J-aggregates with red-shifted and significantly enhanced absorbance. After further complexing with ultra-small iron oxide nanoparticles (IONPs) and the followed functionalization with polyethylene glycol (PEG), the obtained IR825@PAH-IONP-PEG composite nanoparticles are highly stable in different physiological media. With a sharp absorbance peak, IR825@PAH-IONP-PEG can serve as an effective photothermal agent under laser irradiation at 915 nm, which appears to be optimal in photothermal therapy application considering its improved tissue penetration compared with 808-nm light and much lower water heating in comparison to 980-nm light. As revealed by magnetic resonance (MR) imaging, those nanoparticles after intravenous injection exhibit high tumor accumulation, which is then harnessed for in vivo photothermal ablation of tumors, achieving excellent therapeutic efficacy in a mouse tumor model. This study demonstrates for the first time that J-aggregates of organic dye molecules are an interesting class of photothermal material, which when combined with other imageable nanoprobes could serve as a theranostic agent for imaging-guided photothermal therapy of cancer.
authors: Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu, 215123, China.
authors: Xuejiao
authors: X
authors: Song
authors: Hua
authors: H
authors: Gong
authors: Teng
authors: T
authors: Liu
authors: Liang
authors: L
authors: Cheng
authors: Chao
authors: C
authors: Wang
authors: Xiaoqi
authors: X
authors: Sun
authors: Chao
authors: C
authors: Liang
authors: Zhuang
authors: Z
authors: Liu
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D011232:Chemical Precipitation; D004396:Coloring Agents / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry*; D006801:Humans; D006979:Hyperthermia, Induced / Q000295:instrumentation / Q000379:methods*; D008027:Light; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D008807:Mice, Inbred BALB C; D010789:Phototherapy / Q000295:instrumentation / Q000379:methods*; D011092:Polyethylene Glycols / Q000737:chemistry; D020298:U937 Cells; D023041:Xenograft Model Antitumor Assays
chemical_list: D004396:Coloring Agents; D005290:Ferric Compounds; C000499:ferric oxide; D011092:Polyethylene Glycols
keywords: IR825; J-aggregates; iron oxide; magnetic resonance imaging; photothermal therapy