title: Preventable Infections in Children with Leukodystrophy.
abstract: Children with inherited leukodystrophies have high hospitalization rates, often associated with infection. We studied whether potentially modifiable risk factors (pre-existing in-dwelling central intravenous access, urinary catheter, hardware, or mechanical ventilation; and influenza vaccine) were associated with infection-related hospitalization in children with leukodystrophy. Central intravenous access was associated with sepsis (odds ratio (OR) 9.8); urinary catheter was associated with urinary tract infections (OR 9.0); lack of seasonal vaccination was associated with influenza (OR 6.4); and mechanical ventilation was associated with pneumonia (OR 2.7). We conclude that potentially modifiable risk factors are significantly associated with infection and hospitalization in children with leukodystrophies.
authors: School of Medicine, Salt Lake City, Utah.
authors: Holly M
authors: HM
authors: Anderson
authors: Intermountain Healthcare (J.W., E.K.K.), Salt Lake City, Utah.
authors: Jacob
authors: J
authors: Wilkes
authors: Intermountain Healthcare (J.W., E.K.K.), Salt Lake City, Utah.
authors: E Kent
authors: EK
authors: Korgenski
authors: Division of Hematology and Hematological Malignancies (M.A.P.), Salt Lake City, Utah.
authors: Michael A
authors: MA
authors: Pulsipher
authors: Division of Pediatric Infectious Diseases (A.J.B., A.L.H.), Salt Lake City, Utah.
authors: Anne J
authors: AJ
authors: Blaschke
authors: Division of Pediatric Infectious Diseases (A.J.B., A.L.H.), Salt Lake City, Utah.
authors: Adam L
authors: AL
authors: Hersh
authors: Division of Inpatient Medicine (R.S.), Salt Lake City, Utah.
authors: Rajendu
authors: R
authors: Srivastava
authors: Division of Pediatric Neurology (J.L.B.), Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah ; Department of Neurology (J.L.B.), Salt Lake City, Utah.
authors: Joshua L
authors: JL
authors: Bonkowsky
keywords: Leukodystrophy; bronchiolitis; infection; influenza; pneumonia; sepsis