title: Migraine and perimenopause.
abstract: Perimenopause and migraine are closely linked. The hormonal instability during the perimenopausal period not only causes vasomotor symptoms and mood disturbances, but also increases migraine incidence. Women do report new onset migraine during this period, but the increased incidence is reported by women with menstrually related migraine (MRM). The hormonal fluctuations can be stabilized with hormone replacement therapy (HRT), while simultaneously improving the migraine in some patients. The increased stroke risk in women with migraine with aura (MA) should be taken into consideration when intending to treat perimenopausal women with migraine with HRT.
authors: Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.
authors: Khatera
authors: K
authors: Ibrahimi
authors: Boerhaave Medisch Centrum, Johannes Vermeerstraat 31, 1071 DL Amsterdam, The Netherlands.
authors: Emile G M
authors: EG
authors: Couturier
authors: Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands. Electronic address: a.vanharen-maassenvandenbrink@erasmusmc.nl.
authors: Antoinette
authors: A
authors: MaassenVanDenBrink
mesh_terms: D015914:Estrogen Replacement Therapy / Q000009:adverse effects; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D008598:Menstruation; D008881:Migraine Disorders / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D047648:Perimenopause / Q000378:metabolism; D020521:Stroke / Q000209:etiology
chemical_list: D006728:Hormones
keywords: CGRP; Estradiol; Menopause; Menstruation; Migraine