title: A new biocompatible and antibacterial phosphate free glass-ceramic for medical applications.
abstract: In the attempt to find valid alternatives to classic antibiotics and in view of current limitations in the efficacy of antimicrobial-coated or loaded biomaterials, this work is focused on the development of a new glass-ceramic with antibacterial performance together with safe biocompatibility. This bactericidal glass-ceramic composed of combeite and nepheline crystals in a residual glassy matrix has been obtained using an antimicrobial soda-lime glass as a precursor. Its inhibitory effects on bacterial growth and biofilm formation were proved against five biofilm-producing reference strains. The biocompatibility tests by using mesenchymal stem cells derived from human bone indicate an excellent biocompatibility.
authors: Nanomaterials and Nanotechnology Research Center (CINN-CSIC) - Universidad de Oviedo (UO) - Principado de Asturias, Parque Tecnológico de Asturias, 33428, Llanera, Spain.
authors: Belén
authors: B
authors: Cabal
authors: Microbiology Unit, Medicine Department, School of Medicine, Universidad Complutense, Avda. Complutense s/n, 28040 Madrid, Spain.
authors: Luís
authors: L
authors: Alou
authors: Microbiology Unit, Medicine Department, School of Medicine, Universidad Complutense, Avda. Complutense s/n, 28040 Madrid, Spain.
authors: Fabio
authors: F
authors: Cafini
authors: Instituto de Cerámica de Galicia, Avda. Maestro Mateo, 15782 Santiago de Compostela, Spain.
authors: Ramiro
authors: R
authors: Couceiro
authors: Microbiology Unit, Medicine Department, School of Medicine, Universidad Complutense, Avda. Complutense s/n, 28040 Madrid, Spain.
authors: David
authors: D
authors: Sevillano
authors: Institute of Materials Science of Madrid (ICMM-CSIC), Cantoblanco, 28049, Madrid, Spain.
authors: Leticia
authors: L
authors: Esteban-Tejeda
authors: Instituto de Cerámica de Galicia, Avda. Maestro Mateo, 15782 Santiago de Compostela, Spain.
authors: Francisco
authors: F
authors: Guitián
authors: 1] Nanomaterials and Nanotechnology Research Center (CINN-CSIC) - Universidad de Oviedo (UO) - Principado de Asturias, Parque Tecnológico de Asturias, 33428, Llanera, Spain [2] Moscow State University of Technology (STANKIN), Vadkovskij per. 1, Moscow, Moscow Oblast, Russian Federation.
authors: Ramón
authors: R
authors: Torrecillas
authors: Institute of Materials Science of Madrid (ICMM-CSIC), Cantoblanco, 28049, Madrid, Spain.
authors: José S
authors: JS
authors: Moya
mesh_terms: D017607:Aluminum Compounds / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D018441:Biofilms / Q000187:drug effects / Q000254:growth & development; D017610:Calcium Compounds / Q000737:chemistry; D053148:Caspase 3 / Q000378:metabolism; D002448:Cell Adhesion / Q000187:drug effects; D002478:Cells, Cultured; D002516:Ceramics / Q000737:chemistry / Q000494:pharmacology*; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects / Q000502:physiology; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000187:drug effects / Q000201:enzymology; D050296:Microbial Viability / Q000187:drug effects*; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D010087:Oxides / Q000737:chemistry; D017640:Silicates / Q000737:chemistry; D017670:Sodium Compounds / Q000737:chemistry; D012972:Sodium Hydroxide / Q000737:chemistry; D013499:Surface Properties; D013817:Thermography; D013997:Time Factors; D014961:X-Ray Diffraction
chemical_list: D017607:Aluminum Compounds; D000900:Anti-Bacterial Agents; D017610:Calcium Compounds; D020099:Coated Materials, Biocompatible; D010087:Oxides; D017640:Silicates; D017670:Sodium Compounds; C024205:nepheline; C004569:soda lime; D012972:Sodium Hydroxide; C023506:Glass ceramics; D053148:Caspase 3