title: Gonadotroph adenoma causing ovarian hyperstimulation syndrome in a premenopausal woman.
abstract: BACKGROUND
  Gonadotroph adenomas occur commonly in middle-aged adults without any specific endocrinological symptoms. To date, only 30 cases of gonadotropinoma causing ovarian hyperstimulation syndrome in pre-menopausal women have been reported.
  
  
  METHODS
  A 37-year old woman with pituitary macroadenoma and hyperprolactinaemia was admitted to the Department of Endocrinology, Diabetology and Isotope Therapy. She presented with recurrent ovarian cysts, menstrual disturbances, headaches, visual impairment and galactorrhea. Her endocrine profile showed normal values of FSH, elevated concentrations of estradiol and suppressed LH levels. Transsphenoidal resection of the tumor tissue resulted in normalization of the hormone values and improvement in the clinical picture.
  
  
  CONCLUSIONS
  Gonadotroph adenomas should be considered in the differential diagnosis in premenopausal women with OHSS.
authors: Department of Endocrinology, Diabetology and Isotope Therapy, Wroclaw Medical University , Wroclaw , Poland .
authors: Jowita
authors: J
authors: Halupczok
authors: Bożena
authors: B
authors: Bidzińska-Speichert
authors: Agnieszka
authors: A
authors: Lenarcik-Kabza
authors: Grzegorz
authors: G
authors: Zieliński
authors: Alicja
authors: A
authors: Filus
authors: Maria
authors: M
authors: Maksymowicz
mesh_terms: D000236:Adenoma / Q000150:complications* / Q000473:pathology / Q000601:surgery; D000328:Adult; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D052681:Gonadotrophs / Q000473:pathology*; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000150:complications* / Q000601:surgery; D007986:Luteinizing Hormone / Q000097:blood; D016471:Ovarian Hyperstimulation Syndrome / Q000097:blood / Q000209:etiology* / Q000601:surgery; D010911:Pituitary Neoplasms / Q000097:blood / Q000150:complications* / Q000601:surgery; D017697:Premenopause; D016896:Treatment Outcome
chemical_list: D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
keywords: estradiol; follicle-stimulating hormone; gonadotroph adenoma; luteinizing hormone; ovarian hyperstimulation syndrome; α-Subunit