title: A systematic review for anti-inflammatory property of clusiaceae family: a preclinical approach.
abstract: Background. Clusiaceae family (sensu lato) is extensively used in ethnomedicine for treating a number of disease conditions which include cancer, inflammation, and infection. The aim of this review is to report the pharmacological potential of plants of Clusiaceae family with the anti-inflammatory activity in animal experiments. Methods. A systematic review about experiments investigating anti-inflammatory activity of Clusiaceae family was carried out by searching bibliographic databases such as Medline, Scopus and Embase. In this update, the search terms were "anti-inflammatory agents," "Clusiaceae," and "animals, laboratory." Results. A total of 255 publications with plants this family were identified. From the initial 255 studies, a total of 21 studies were selected for the final analysis. Studies with genera Allanblackia, Clusia, Garcinia or Rheedia, and Hypericum showed significant anti-inflammatory activity. The findings include a decrease of total leukocytes, a number of neutrophils, total protein concentration, granuloma formation, and paw or ear edema formation. Other interesting findings included decreased of the MPO activity, and inflammatory mediators such as NF- κ B and iNOS expression, PGE2 and Il-1 β levels and a decrease in chronic inflammation. Conclusion. The data reported suggests the anti-inflammatory effect potential of Clusiaceae family in animal experiments.
authors: Department of Physiology, Federal University of Sergipe, São Cristóvão, SE, Brazil.
authors: Mônica Santos
authors: MS
authors: de Melo
authors: Department of Physiology, Federal University of Sergipe, São Cristóvão, SE, Brazil.
authors: Jullyana de Souza Siqueira
authors: Jde S
authors: Quintans
authors: Department of Pharmacy, Federal University of Sergipe, São Cristóvão, SE, Brazil.
authors: Adriano Antunes de Souza
authors: AA
authors: Araújo
authors: Department of Pharmacy, Federal University of Sergipe, São Cristóvão, SE, Brazil.
authors: Marcelo Cavalcante
authors: MC
authors: Duarte
authors: Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil.
authors: Leonardo Rigoldi
authors: LR
authors: Bonjardim
authors: Department of Chemistry, Federal University of Sergipe, São Cristóvão, SE, Brazil.
authors: Paulo Cesar de Lima
authors: 0000-0003-0832-1047
authors: PC
authors: Nogueira
authors: Department of Chemistry, Federal University of Sergipe, São Cristóvão, SE, Brazil.
authors: Valéria Regina de Souza
authors: VR
authors: Moraes
authors: School of Nursing and Pharmacy, Federal University of Alagoas, Maceió, AL, Brazil.
authors: João Xavier
authors: JX
authors: de Araújo-Júnior
authors: School of Nursing and Pharmacy, Federal University of Alagoas, Maceió, AL, Brazil.
authors: Eurica Adélia Nogueira
authors: 0000-0001-7983-7521
authors: EA
authors: Ribeiro
authors: Department of Physiology, Federal University of Sergipe, São Cristóvão, SE, Brazil ; Laboratory of Pre-Clinical Pharmacology (LAPEC), Department of Physiology, Federal University of Sergipe (UFS), São Cristóvão, SE, Brazil.
authors: Lucindo José
authors: 0000-0001-5155-938X
authors: LJ
authors: Quintans-Júnior