title: Induction chemotherapy with docetaxel, cisplatin and fluorouracil followed by surgery and concurrent chemoradiotherapy improves outcome of recurrent advanced head and neck squamous cell carcinoma.
abstract: BACKGROUND
  Locally recurrent rate of advanced head and neck squamous cell carcinoma (HNSCC) still remains high and the treatment is controversial.
  
  
  METHODS
  We retrospectively analyzed ninety-three patients with recurrent advanced oral cancer from 2009 to 2013. Sixty-four patients are in the docetaxel with cisplatin and 5'-fluorouracil (TPF) group and the remaining twenty-nine patients are in the cisplatin and 5'-fluorouracil (PF) group.
  
  
  RESULTS
  The overall response rate was better in the TPF group (p=0.005) than the PF group. Patients who received induction chemotherapy, TPF, followed by surgery and concurrent chemoradiotherapy (CRT) had better overall survival (OS) (p=0.012) and progression-free survival (PFS) (p=0.038), while patients with prior intra-arterial-infusion-chemotherapy had an adverse impact on OS (p=0.039).
  
  
  CONCLUSIONS
  We showed that induction chemotherapy with TPF, followed by surgery and consolidation CRT, is the ideal choice for recurrent advanced HNSCC with improving response rates and survival. However, prior intra-arterial-infusion-chemotherapy showed an adverse impact.
authors: Division of Hematology and Medical Oncology, Department of Internal Medicine, Yuan's General Hospital, Kaohsiung, Taiwan, R.O.C. Molecular Medicine Lab, Yuan's General Hospital, Kaohsiung, Taiwan, R.O.C.
authors: Wen-Chi
authors: WC
authors: Yang
authors: Division of Oral Maxillofacial Surgery, Department of Dentistry, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, R.O.C.
authors: Chung-Ho
authors: CH
authors: Chen
authors: Department of Radiation Oncology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, R.O.C.
authors: Jen-Yang
authors: JY
authors: Tang
authors: Division of Surgical Oncology, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, R.O.C.
authors: Chih-Fung
authors: CF
authors: Wu
authors: Division of Hematology and Medical Oncology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, R.O.C.
authors: Yi-Chang
authors: YC
authors: Liu
authors: Department of Radiation Oncology, Columbia University College of Physicians and Surgeons, New York, NY, U.S.A.
authors: Youping
authors: Y
authors: Sun
authors: Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C. Division of Hematology and Medical Oncology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, R.O.C. shlin@kmu.edu.tw.
authors: Sheng-Fung
authors: SF
authors: Lin
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D059248:Chemoradiotherapy; D002945:Cisplatin / Q000008:administration & dosage; D000077143:Docetaxel; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy; D012189:Retrospective Studies; D000077195:Squamous Cell Carcinoma of Head and Neck; D043823:Taxoids / Q000008:administration & dosage
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D002945:Cisplatin; D005472:Fluorouracil
keywords: IAIC; TPF; head and neck cancer