title: Placental oxidative status in rural residents environmentally exposed to organophosphates.
abstract: The impact of environmental organophosphate pesticide exposure on the placenta oxidative status was assessed. Placental samples were collected from women residing in an agricultural area during pesticide pulverization period, non-pulverization period and from control group. Carboxylesterase activity was significantly decreased in pulverization period group. Enzymatic and non-enzymatic defense system, the oxidative stress biomarkers and the nuclear factor erythroid 2-related factor levels showed no differences among groups. However, in the pulverization period group, an inverse association between catalase activity and placental index, a useful metric for estimating placental inefficiency, was found. This result suggests that catalase may serve as a potential placental biomarker of susceptibility to pesticides. Further studies designed from a gene-environment perspective are needed.
authors: Facultad de Ciencias Médicas, Universidad Nacional del Comahue, Cipolletti, Río Negro, Argentina; LIBIQUIMA, Instituto Multidisciplinario de Investigación y Desarrollo de la Patagonia Norte (IDEPA), CONICET - Universidad Nacional del Comahue, Neuquén, Argentina. Electronic address: grachiapella@live.com.ar.
authors: Graciela
authors: G
authors: Chiapella
authors: Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina. Electronic address: sgenti@fcq.unc.edu.ar.
authors: Susana
authors: S
authors: Genti-Raimondi
authors: Facultad de Ciencias Médicas, Universidad Nacional del Comahue, Cipolletti, Río Negro, Argentina; LIBIQUIMA, Instituto Multidisciplinario de Investigación y Desarrollo de la Patagonia Norte (IDEPA), CONICET - Universidad Nacional del Comahue, Neuquén, Argentina. Electronic address: ggmag23@gmail.com.
authors: Gladis
authors: G
authors: Magnarelli
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D043182:Carboxylesterase / Q000378:metabolism; D002374:Catalase / Q000378:metabolism*; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation; D051267:NF-E2-Related Factor 2 / Q000378:metabolism; D010755:Organophosphates / Q000633:toxicity*; D018384:Oxidative Stress; D010575:Pesticides / Q000633:toxicity*; D010920:Placenta / Q000187:drug effects* / Q000378:metabolism; D011247:Pregnancy; D050050:Protein Carbonylation; D012424:Rural Population; D055815:Young Adult
chemical_list: D015415:Biomarkers; D051267:NF-E2-Related Factor 2; C495635:NFE2L2 protein, human; D010755:Organophosphates; D010575:Pesticides; C577219:CAT protein, human; D002374:Catalase; D005979:Glutathione Peroxidase; D043182:Carboxylesterase; D005978:Glutathione
keywords: Catalase; Pesticides; Placenta; Placental index