title: Copper-catalyzed direct C-2 difluoromethylation of furans and benzofurans: access to C-2 CF2H derivatives.
abstract: We report herein the first copper-catalyzed C-2 difluoromethylation of furans and benzofurans. The developed methodology allows the selective introduction of the CF2CO2Et moiety at C-2 using CuI as a catalyst. This process was applied to a broad range of furans and benzofurans, giving the functionalized products in moderate to good yields. The resulting products were then decarboxylated to afford the highly valuable C-2-CF2H-substituted furans and benzofurans in good yields.
authors: Normandie Université, COBRA, UMR 6014 et FR 3038; Université de Rouen; INSA Rouen; CNRS, 1 rue Tesnière, 76821 Mont Saint-Aignan Cedex, France.
authors: Marie-Charlotte
authors: MC
authors: Belhomme
authors: Thomas
authors: T
authors: Poisson
authors: Xavier
authors: X
authors: Pannecoucke
mesh_terms: D001572:Benzofurans / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D005663:Furans / Q000737:chemistry*; D007454:Iodides / Q000737:chemistry*; D008745:Methylation; D015394:Molecular Structure
chemical_list: D001572:Benzofurans; D005663:Furans; D007454:Iodides; D003300:Copper; C073870:cuprous iodide