title: Interaction of Mycobacterium tuberculosis with host cell death pathways.
abstract: Mycobacterium tuberculosis (Mtb) has coevolved with humans for tens of thousands of years. It is thus highly adapted to its human host and has evolved multiple mechanisms to manipulate host immune responses to its advantage. One central host pathogen interaction modality is host cell death pathways. Host cell apoptosis is associated with a protective response to Mtb infection, whereas a necrotic response favors the pathogen. Consistently, Mtb inhibits host cell apoptosis signaling but promotes induction of programmed necrosis. The molecular mechanisms involved in Mtb-mediated host cell death manipulation, the consequences for host immunity, and the potential for therapeutic and preventive approaches will be discussed.
authors: Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742.
authors: Lalitha
authors: L
authors: Srinivasan
authors: Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742.
authors: Sarah
authors: S
authors: Ahlbrand
authors: Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742.
authors: Volker
authors: V
authors: Briken
mesh_terms: D017209:Apoptosis / Q000235:genetics / Q000502:physiology*; D054884:Host-Pathogen Interactions / Q000235:genetics / Q000502:physiology; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology*; D009336:Necrosis / Q000235:genetics / Q000382:microbiology / Q000503:physiopathology; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D014376:Tuberculosis / Q000382:microbiology / Q000517:prevention & control / Q000628:therapy