title: Identification of susceptibility variants in ADIPOR1 gene associated with type 2 diabetes, coronary artery disease and the comorbidity of type 2 diabetes and coronary artery disease.
abstract: OBJECTIVE
  Adiponectin receptor 1 (encoded by ADIPOR1) is one of the major adiponectin receptors, and plays an important role in glucose and lipid metabolism. However, few studies have reported simultaneous associations between ADIPOR1 variants and type 2 diabetes (T2D), coronary artery disease (CAD) and T2D with CAD. Based on the "common soil" hypothesis, we investigated whether ADIPOR1 polymorphisms contributed to the etiology of T2D, CAD, or T2D with CAD in a Northern Han Chinese population.
  
  
  METHODS
  Our multi-disease comparison study enrolled 657 subjects, including 165 with T2D, 173 with CAD, 174 with both T2D and CAD (T2D+CAD), and 145 local healthy controls. Six ADIPOR1 single nucleotide polymorphisms (SNPs) were genotyped and their association with disease risk was analyzed.
  
  
  RESULTS
  Multi-case-control comparison identified two ADIPOR1 variants: rs3737884-G, which was simultaneously associated with an increased risk of T2D, CAD, and T2D+CAD (P-value range, 9.80×10(-5)-6.30×10(-4); odds ratio (OR) range: 1.96-2.42) and 16850797-C, which was separately associated with T2D and T2D+CAD (P-value range: 0.007-0.014; OR range: 1.71-1.77). The risk genotypes of both rs3737884 and 16850797 were consistently associated with common metabolic phenotypes in all three diseases (P-value range: 4.81×10(-42)-0.001). We observed an increase in the genetic dose-dependent cumulative risk with increasing risk allele numbers in T2D, CAD and T2D+CAD (P trend from 1.35×10(-5)-0.002).
  
  
  CONCLUSIONS
  Our results suggest that ADIPOR1 risk polymorphisms are a strong candidate for the "common soil" hypothesis and could partially contribute to disease susceptibility to T2D, CAD, and T2D with CAD in the Northern Han Chinese population.
authors: Department of Emergency Medicine, Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessels, Beijing, China.
authors: Zening
authors: Z
authors: Jin
authors: Department of Emergency Medicine, Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessels, Beijing, China.
authors: Lianmei
authors: L
authors: Pu
authors: The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Chinese Ministry of Health, Beijing, China.
authors: Liang
authors: L
authors: Sun
authors: Department of Cardiology, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
authors: Weijun
authors: W
authors: Chen
authors: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessels, Beijing, China.
authors: Nan
authors: N
authors: Nan
authors: Department of Emergency Medicine, Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessels, Beijing, China.
authors: Hong
authors: H
authors: Li
authors: Department of Emergency Medicine, Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessels, Beijing, China.
authors: Huagang
authors: H
authors: Zhu
authors: Department of Functional Tests, Beijing You'an Hospital, Capital Medical University, Beijing, China.
authors: Xinmiao
authors: X
authors: Yang
authors: The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Chinese Ministry of Health, Beijing, China.
authors: Nana
authors: N
authors: Wang
authors: The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Chinese Ministry of Health, Beijing, China.
authors: Juan
authors: J
authors: Hui
authors: The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Chinese Ministry of Health, Beijing, China.
authors: Yurong
authors: Y
authors: Zhang
authors: Department of Neurology, Jiangbin hospital, Nanning, China.
authors: Qin
authors: Q
authors: Zhou
authors: The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Chinese Ministry of Health, Beijing, China.
authors: Fan
authors: F
authors: Zhao
authors: The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Chinese Ministry of Health, Beijing, China.
authors: Fan
authors: F
authors: Yang
authors: The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Chinese Ministry of Health, Beijing, China.
authors: Xiaohong
authors: X
authors: Shi
authors: The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Chinese Ministry of Health, Beijing, China.
authors: Xiaoquan
authors: X
authors: Zhu
authors: The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Chinese Ministry of Health, Beijing, China.
authors: Yige
authors: Y
authors: Yang
authors: Human Health Therapeutics, Institute for Biological Sciences, National Research Council of Canada, Ottawa, Canada.
authors: Wandong
authors: W
authors: Zhang
authors: Department of Cardiac Surgery, Guangxi Zhuang Autonomous Region Women and Children Care Hospital, Nanning, China.
authors: Chenguang
authors: C
authors: Zheng
authors: Department of Emergency Medicine, Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessels, Beijing, China.
authors: Xiang
authors: X
authors: Li
authors: Department of Emergency Medicine, Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessels, Beijing, China.
authors: Duo
authors: D
authors: Yang
authors: Department of Emergency Medicine, Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessels, Beijing, China.
authors: Ruofei
authors: R
authors: Jia
authors: Department of Emergency Medicine, Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessels, Beijing, China.
authors: Shuai
authors: S
authors: Meng
authors: The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Chinese Ministry of Health, Beijing, China.
authors: Ze
authors: Z
authors: Yang
mesh_terms: D000368:Aged; D044466:Asian People / Q000208:ethnology / Q000235:genetics; D016022:Case-Control Studies; D015897:Comorbidity; D003324:Coronary Artery Disease / Q000453:epidemiology* / Q000208:ethnology / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000208:ethnology / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D060005:Genotyping Techniques; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D054419:Receptors, Adiponectin / Q000235:genetics*
chemical_list: C475418:ADIPOR1 protein, human; D054419:Receptors, Adiponectin