title: The promise and challenges of cardiac stem cell therapy.
abstract: After an extensive myocardial infarction, restoration of heart function depends on the ability of the heart to promote regeneration and prevent adverse ventricular remodeling. Preclinical research demonstrated that the transplantation of healthy stem cells restored heart function, but the stem cells obtained from older animals or patients were not as efficacious as those from younger individuals. In this paper, we review the successes and limitations discovered in preclinical studies and clinical trials examining cell therapy for damaged hearts. After the modest successes of the early clinical trials, research is now exploring the benefits of enhanced stem cell therapy. Cell based gene therapy markedly improves the angiogenesis achieved. Rejuvenating aged stems cells prior to transplantation restores the functional benefits attained. Transplanting healthy allogeneic stem cells from young donors into aged individuals can restore function if rejection can be prevented. Finally, modulating the cellular environment in aged individuals permits the full functional benefits of stem cell therapy to be realized. Significant challenges remain, but these approaches show promise that cell therapy may become routine therapy to improve functional recovery of older patients after an extensive myocardial infarction.
authors: Division of Cardiovascular Surgery, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada.; Division of Cardiac Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
authors: Nathan C
authors: NC
authors: Ni
authors: Division of Cardiovascular Surgery, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada.; Division of Cardiac Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
authors: Ren-Ke
authors: RK
authors: Li
authors: Division of Cardiovascular Surgery, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada.; Division of Cardiac Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.. Electronic address: rweisel@uhnresearch.ca.
authors: Richard D
authors: RD
authors: Weisel
mesh_terms: D000818:Animals; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D006331:Heart Diseases / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D033581:Stem Cell Transplantation / Q000379:methods*; D016896:Treatment Outcome; D020257:Ventricular Remodeling
keywords: aging; rejuvenation; stem cell; stem cell therapy