title: Pavlovian discriminative stimulus effects of methamphetamine in male Japanese quail (Coturnix japonica).
abstract: Pavlovian drug discrimination (DD) procedures demonstrate that interoceptive drug stimuli may come to control behavior by informing the status of conditional relationships between stimuli and outcomes. This technique may provide insight into processes that contribute to drug-seeking, relapse, and other maladaptive behaviors associated with drug abuse. The purpose of the current research was to establish a model of Pavlovian DD in male Japanese quail. A Pavlovian conditioning procedure was used such that 3.0 mg/kg methamphetamine served as a feature positive stimulus for brief periods of visual access to a female quail and approach behavior was measured. After acquisition training, generalization tests were conducted with cocaine, nicotine, and haloperidol under extinction conditions. SCH 23390 was used to investigate the involvement of the dopamine D1 receptor subtype in the methamphetamine discriminative stimulus. Results showed that cocaine fully substituted for methamphetamine but nicotine only partially substituted for methamphetamine in quail. Haloperidol dose-dependently decreased approach behavior. Pretreatment with SCH 23390 modestly attenuated the methamphetamine discrimination suggesting that the D1 receptor subtype may be involved in the discriminative stimulus effects of methamphetamine. The findings are discussed in relation to drug abuse and associated negative health consequences.
authors: University of Kentucky.
authors: B
authors: B
authors: Levi Bolin
authors: Destiny L
authors: DL
authors: Singleton
authors: Chana K
authors: CK
authors: Akins
mesh_terms: D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003042:Cocaine / Q000494:pharmacology; D003214:Conditioning, Classical / Q000187:drug effects; D003370:Coturnix; D004192:Discrimination, Psychological / Q000187:drug effects*; D005260:Female; D005793:Generalization, Psychological / Q000187:drug effects; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D009538:Nicotine / Q000494:pharmacology; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors; D012726:Sexual Behavior, Animal / Q000187:drug effects
chemical_list: D001552:Benzazepines; D000697:Central Nervous System Stimulants; D017447:Receptors, Dopamine D1; C534628:SCH 23390; D008694:Methamphetamine; D009538:Nicotine; D003042:Cocaine; D006220:Haloperidol
keywords: Japanese quail; approach behavior; discriminative stimulus; drug discrimination; feature positive; methamphetamine; sexual motivation