title: A bittersweet symphony.
abstract: This issue analyzes new work expanding the range of how genetic dysregulation of succinate dehydrogenase subunit (SDHx) genes can cause cancer syndromes with a prominent endocrine component, in this case Carney triad, which is characterized by gastrointestinal stromal tumors, paraganglioma, and pulmonary chondromas.
authors: Department of EndocrinologyCentre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart-Tilman, 4000 Liège, Belgium adrian.daly@ulg.ac.be.
authors: Adrian F
authors: AF
authors: Daly
authors: Department of EndocrinologyCentre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart-Tilman, 4000 Liège, Belgium.
authors: Albert
authors: A
authors: Beckers
mesh_terms: D002812:Chondroma / Q000235:genetics*; D004701:Endocrine Gland Neoplasms / Q000235:genetics; D044127:Epigenesis, Genetic; D006801:Humans; D007890:Leiomyosarcoma / Q000235:genetics*; D008175:Lung Neoplasms / Q000235:genetics*; D009154:Mutation; D010236:Paraganglioma, Extra-Adrenal / Q000235:genetics*; D021122:Protein Subunits / Q000235:genetics; D013274:Stomach Neoplasms / Q000235:genetics*; D013385:Succinate Dehydrogenase / Q000235:genetics*
chemical_list: D021122:Protein Subunits; D013385:Succinate Dehydrogenase
keywords: Carney triad; gene regulation