title: Phenotype standardization of angioedema in the head and neck region caused by agents acting on the angiotensin system.
abstract: Angioedema is a potentially life-threatening adverse reaction to angiotensin-converting enzyme inhibitors and angiotensin receptor blockers. To study the genetic etiology of this rare adverse event, international consortia and multicenter recruitment of patients are needed. To reduce patient heterogeneity, we have standardized the phenotype. In brief, it comprises swelling in the head and neck region that first occurs during treatment. It should not coincide with urticaria or have another likely cause such as hereditary angioedema.
authors: Department of Medical Sciences, Clinical Pharmacology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
authors: M
authors: M
authors: Wadelius
authors: Medical Research Institute, College of Medicine, Dentistry and Nursing, University of Dundee, Ninewells Hospital, Dundee, UK.
authors: S E
authors: SE
authors: Marshall
authors: Department of Intensive and Perioperative Care, Skåne University Hospital, Lund, Sweden.
authors: G
authors: G
authors: Islander
authors: Department of Surgical Sciences, Otorhinolaryngology, and Head & Neck Surgery, Uppsala University, Uppsala, Sweden.
authors: L
authors: L
authors: Nordang
authors: Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden.
authors: M
authors: M
authors: Karawajczyk
authors: Medical Products Agency, Uppsala, Sweden.
authors: Q-Y
authors: QY
authors: Yue
authors: Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands.
authors: I
authors: I
authors: Terreehorst
authors: Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht University, Utrecht, The Netherlands.
authors: E V
authors: EV
authors: Baranova
authors: Department of Otorhinolaryngology, Örebro University Hospital and Örebro University, Örebro, Sweden.
authors: S
authors: S
authors: Hugosson
authors: Department of Otorhinolaryngology, Hudiksvall Hospital, Hudiksvall, Sweden.
authors: K
authors: K
authors: Sköldefors
authors: Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.
authors: M
authors: M
authors: Pirmohamed
authors: Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht University, Utrecht, The Netherlands.
authors: A-H
authors: AH
authors: Maitland-van der Zee
authors: Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.
authors: A
authors: A
authors: Alfirevic
authors: Department of Medical Sciences, Clinical Pharmacology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
authors: P
authors: P
authors: Hallberg
authors: Medical Research Institute, College of Medicine, Dentistry and Nursing, University of Dundee, Ninewells Hospital, Dundee, UK.
authors: C N A
authors: CN
authors: Palmer
mesh_terms: D000799:Angioedema / Q000139:chemically induced* / Q000145:classification / Q000453:epidemiology; D057911:Angiotensin Receptor Antagonists / Q000009:adverse effects*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D001920:Bradykinin / Q000378:metabolism; D006257:Head; D006801:Humans; D009333:Neck; D010641:Phenotype; D012307:Risk Factors
chemical_list: D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D001920:Bradykinin