title: Systemic response to ultraviolet radiation involves induction of leukocytic IL-1β and inflammation in zebrafish.
abstract: Ultraviolet radiation is a pervasive stimulus with wide-ranging effects on all living forms. The effects of UV vary from physiological to pathological, depending on levels of exposure, but the immune response at the organismal level is not well understood. We use the zebrafish embryo and larva to study immune responses to UV stress in vivo. UV exposure causes inflammation characterized by systemic induction of proinflammatory cytokines. Leukocytes are an important component of this systemic response and upregulate IL-1β expression proportional to the dose of UV exposure. Increased levels of this proinflammatory cytokine counteract the lethal effect of high doses of UV.
authors: Institute of Genetics, University of Cologne, 50674 Cologne, Germany; and European Molecular Biology Laboratory, 69117 Heidelberg, Germany.
authors: Sanjita
authors: S
authors: Banerjee
authors: Institute of Genetics, University of Cologne, 50674 Cologne, Germany; and European Molecular Biology Laboratory, 69117 Heidelberg, Germany maria.leptin@embo.org.
authors: Maria
authors: M
authors: Leptin
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D004195:Disease Models, Animal; D004625:Embryo, Nonmammalian / Q000276:immunology / Q000473:pathology / Q000528:radiation effects; D007249:Inflammation / Q000209:etiology / Q000235:genetics / Q000401:mortality; D018836:Inflammation Mediators / Q000378:metabolism* / Q000528:radiation effects; D053583:Interleukin-1beta / Q000096:biosynthesis* / Q000235:genetics / Q000528:radiation effects*; D007814:Larva / Q000235:genetics / Q000276:immunology / Q000528:radiation effects; D007962:Leukocytes / Q000276:immunology / Q000473:pathology / Q000528:radiation effects*; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism / Q000528:radiation effects; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology / Q000528:radiation effects; D014466:Ultraviolet Rays / Q000009:adverse effects; D015027:Zebrafish / Q000235:genetics / Q000276:immunology*
chemical_list: D018836:Inflammation Mediators; D053583:Interleukin-1beta; D016328:NF-kappa B