title: Magnetite nanostructures functionalized with cytostatic drugs exhibit great anti-tumoral properties without application of high amplitude alternating magnetic fields.
abstract: Here, we report the synthesis, characterization and the impact of magnetite nanoparticles functionalized with cytostatic drugs, epirubicin (Epi) and fludarabine (Flu) (Fe3O4@Epi, Fe3O4@Flu) prepared by chemical co-precipitation method on tumoral cells in vitro. The average diameter of the resulted particles was about 4 nm for both Fe3O4@Epi and for Fe3O4@Flu. These bioactive nanostructured materials proved to significantly enhance the antitumor effect of tested cytostatic drugs in vitro. The most significant result was obtained in the case of Epi, where the tested magnetite nanostructured material enhanced the cytotoxic effect of this drug with more than 50%.
authors: Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Romania; grumezescu@yahoo.com.
authors: Georgeta
authors: G
authors: Voicu
authors: Livia Elena
authors: LE
authors: Crică
authors: Oana
authors: O
authors: Fufă
authors: Lavinia Iuliana
authors: LI
authors: Moraru
authors: Roxana Cristina
authors: RC
authors: Popescu
authors: Gabriela
authors: G
authors: Purcel
authors: Miruna Codruta
authors: MC
authors: Stoilescu
authors: Alexandru Mihai
authors: AM
authors: Grumezescu
authors: Coralia
authors: C
authors: Bleotu
authors: Alina Maria
authors: AM
authors: Holban
authors: Ecaterina
authors: E
authors: Andronescu
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D054697:Cytostatic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D006801:Humans; D060526:Magnetic Fields; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use; D010316:Particle Size; D014407:Tumor Cells, Cultured; D014961:X-Ray Diffraction
chemical_list: D000970:Antineoplastic Agents; D054697:Cytostatic Agents; D058185:Magnetite Nanoparticles