title: Microfluidic conceived drug loaded Janus particles in side-by-side capillaries device.
abstract: A side-by-side capillaries microfluidic device was developed to fabricate drug loaded poly(acrylamide)/poly(methyl acrylate) Janus particles in the range of 59-240 μm by UV-assisted free radical polymerization. This system was characterized in terms of continuous and dispersed phases flow rates (Qc/Qd), monomer composition of the two compartments, surfactant nature and concentration, outlet tube diameter and UV intensity. These factors were adequately controlled to get different particle shapes ranging from core-shell to bi-compartmental particles. For the latter, a low surfactant concentration (0.75 wt.%) was necessary when the two dispersed phases were pumped at equal flow rate, while at high surfactant concentration, dispersed phases flow rates have to be changed. FTIR analysis suggested complete polymerization of monomers and cytotoxicity test showed these particles were biocompatible having LD 50 of 9 mg/mL. Both ketoprofen and sodium fluorescein were released in sustained release manner at pH 6.8 by following a diffusion type release mechanism. Drug release was faster for bigger particles and found to result from the irregular distribution of the two phases and indentation on bigger particles as revealed by SEM analysis. In comparison, sodium fluorescein release was slower which was attributed to low encapsulation but could be modified by decreasing crosslinker concentration.
authors: Laboratory of Design and Application of Bioactive Molecules (CAMB), Faculty of Pharmacy, University of Strasbourg (UdS), Strasbourg, France; Group for the Intensification and Integration of Polymer Processes (G2IP), Institute of Chemistry and Processes for Energy, Environment and Health (ICPEES - UMR 7515 CNRS), European Engineering School of Chemistry, Polymers and Materials Science (ECPM), University of Strasbourg (UdS), CNRS UMR 7515, Strasbourg, France; College of Pharmacy, Government College University, Faisalabad, Pakistan. Electronic address: ikramglt@gmail.com.
authors: Ikram Ullah
authors: IU
authors: Khan
authors: Group for the Intensification and Integration of Polymer Processes (G2IP), Institute of Chemistry and Processes for Energy, Environment and Health (ICPEES - UMR 7515 CNRS), European Engineering School of Chemistry, Polymers and Materials Science (ECPM), University of Strasbourg (UdS), CNRS UMR 7515, Strasbourg, France. Electronic address: ca.serra@unistra.fr.
authors: Christophe A
authors: CA
authors: Serra
authors: Laboratory of Design and Application of Bioactive Molecules (CAMB), Faculty of Pharmacy, University of Strasbourg (UdS), Strasbourg, France.
authors: Nicolas
authors: N
authors: Anton
authors: Laboratory of Design and Application of Bioactive Molecules (CAMB), Faculty of Pharmacy, University of Strasbourg (UdS), Strasbourg, France.
authors: Xiang
authors: X
authors: Li
authors: Laboratory of Design and Application of Bioactive Molecules (CAMB), Faculty of Pharmacy, University of Strasbourg (UdS), Strasbourg, France; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia.
authors: Roman
authors: R
authors: Akasov
authors: Institute of Genetics and Molecular and Cellular Biology (IGBMC), CNRS/INSERM/Collège de France, Illkirch, France.
authors: Nadia
authors: N
authors: Messaddeq
authors: Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), UPR 22 CNRS, F-67034 Strasbourg, France.
authors: Isabelle
authors: I
authors: Kraus
authors: Laboratory of Design and Application of Bioactive Molecules (CAMB), Faculty of Pharmacy, University of Strasbourg (UdS), Strasbourg, France.
authors: Thierry F
authors: TF
authors: Vandamme
mesh_terms: D000180:Acrylic Resins / Q000008:administration & dosage / Q000737:chemistry; D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry; D019793:Fluorescein / Q000008:administration & dosage / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D007660:Ketoprofen / Q000008:administration & dosage / Q000737:chemistry; D051379:Mice; D046210:Microfluidic Analytical Techniques; D011109:Polymethacrylic Acids / Q000008:administration & dosage / Q000737:chemistry; D011136:Polysorbates / Q000737:chemistry; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry; D000099166:Polyacrylamides
chemical_list: D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D019793:Fluorescein; D007660:Ketoprofen; D011109:Polymethacrylic Acids; D011136:Polysorbates; D012967:Sodium Dodecyl Sulfate; D013501:Surface-Active Agents; D000099166:Polyacrylamides; C030613:polymethacrylic acid
keywords: Cytotoxicity; Drug delivery; Janus particles; Microfluidics; Poly(acrylamide); Poly(methyl acrylate)