title: Clinical significance of expression of tissue factor and tissue factor pathway inhibitor in ulcerative colitis.
abstract: OBJECTIVE
  To investigate the clinical significance of expression of tissue factor (TF) and tissue factor pathway inhibitor (TFPI) in ulcerative colitis (UC).
  
  
  METHODS
  Thirty UC specimens taken by colonoscopy from patients with active UC treated at the Department of Pathology, Central Hospital Affiliated to Shenyang Medical College from February 2010 to January 2012 were included in an experimental group, and 30 normal colon tissue samples taken by colonoscopy from non-UC patients were included in a control group. Expression of TF and TFPI in UC and normal colon tissue samples was detected by immunohistochemistry.
  
  
  RESULTS
  The positive rate of TF in UC was significantly higher than that in normal colon tissue (63% vs 33%, χ(2) = 5.41, P < 0.05). The positive rate of TFPI in UC was also significantly higher than that in normal colon tissue (43% vs 17%, χ(2) = 5.08, P < 0.05).
  
  
  CONCLUSIONS
  Positive rates of TF and TFPI expression in UC are significantly higher than those in normal colon tissue. TF and TFPI may play an important role in the pathogenesis of UC.
authors: Hao-Lan He, Qian Li, Department of Gastroenterology, Central Hospital Affiliated to Shenyang Medical College, Shenyang 110024, Liaoning Province, China.
authors: Hao-Lan
authors: HL
authors: He
authors: Hao-Lan He, Qian Li, Department of Gastroenterology, Central Hospital Affiliated to Shenyang Medical College, Shenyang 110024, Liaoning Province, China.
authors: Ji-Bin
authors: JB
authors: Zhang
authors: Hao-Lan He, Qian Li, Department of Gastroenterology, Central Hospital Affiliated to Shenyang Medical College, Shenyang 110024, Liaoning Province, China.
authors: Qian
authors: Q
authors: Li
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D016022:Case-Control Studies; D002681:China; D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000378:metabolism*; D003106:Colon / Q000737:chemistry* / Q000473:pathology; D003113:Colonoscopy; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008074:Lipoproteins / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D013925:Thromboplastin / Q000032:analysis*; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D008074:Lipoproteins; C051928:lipoprotein-associated coagulation inhibitor; D013925:Thromboplastin
keywords: Tissue factor; Tissue factor pathway inhibitor; Ulcerative colitis