title: Rapid detection and characterization of major phenolic compounds in Radix Actinidia chinensis Planch by ultra-performance liquid chromatography tandem mass spectrometry.
abstract: Radix Actinidia chinensis Planch is a traditional Chinese herb, and its decotion had been widely used clinically to treat several types of cancer. In our study, the phenolic compounds constituting the major water soluble components of Radix A. chinensis were profiled and characterized by ultraperformance liquid chromatography electrospray ionization tandem mass spectrometry. A total of 50 compounds were identified or tentatively characterized, including caffeic acid, p-coumaric acid, 29 catechin derivatives, 12 quinic acid derivatives and 7 coumarin derivatives. Most of the identified compounds were firstly reported from A. chinensis. Among them, scopoletin, scoplin, isofraxoside and quinic acid derivatives have not ever been reported from genus Actinidia previously. These phenolic compounds might be responsible for the antitumor activity of the water extract of radix A. chinensis, and the established analytical method could be applied to further study of quality evaluation and active components of Radix A. chinensis.
authors: Pharmacy Department, China-Japan Friendship Hospital, Beijing, China.
authors: Tie
authors: T
authors: Zhao
authors: Pharmacy Department, China-Japan Friendship Hospital, Beijing, China.
authors: Jun
authors: J
authors: He
authors: Pharmacy Department, China-Japan Friendship Hospital, Beijing, China.
authors: Xiaoxue
authors: X
authors: Wang
authors: Pharmacy Department, China-Japan Friendship Hospital, Beijing, China.
authors: Bingzhi
authors: B
authors: Ma
authors: Pharmacy Department, China-Japan Friendship Hospital, Beijing, China.
authors: Xiaoxing
authors: X
authors: Wang
authors: Pharmacy Department, China-Japan Friendship Hospital, Beijing, China.
authors: Lei
authors: L
authors: Zhang
authors: Department of Pharmacology, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.
authors: Ping
authors: P
authors: Li
authors: Institute Of Microbiology, Chinese Academy of Sciences, China.
authors: Ning
authors: N
authors: Liu
authors: Pharmacy Department, China-Japan Friendship Hospital, Beijing, China.
authors: Jin
authors: J
authors: Lu
authors: Pharmacy Department, China-Japan Friendship Hospital, Beijing, China. Electronic address: zryhyyzxl@sina.com.
authors: Xianglin
authors: X
authors: Zhang
mesh_terms: D029042:Actinidia / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D010636:Phenols / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry; D053719:Tandem Mass Spectrometry / Q000379:methods
chemical_list: D004365:Drugs, Chinese Herbal; D010636:Phenols
keywords: Phenols; Radix Actinidia chinensis Planch; Structural characterization; UPLC–TOF/MS; UPLC–TQ/MS