title: AGR2-mediated lung adenocarcinoma metastasis novel mechanism network through repression with interferon coupling cytoskeleton to steroid metabolism-dependent humoral immune response.
abstract: 7 anterior gradient homolog 2 (AGR2)-inhibited different molecular mutual positive correlation network was constructed in lung adenocarcinoma compared with human normal adjacent tissues by 17 overlapping molecules of 358 GRNInfer and 19 Pearson (AGR2 CC⩽-0.25). Based on GO, KEGG, GenMAPP, BioCarta and disease databases, we determined AGR2-mediated lung adenocarcinoma metastasis through repression with cytoskeleton of MAST1; steroid metabolism of SOAT2; humoral immune response of POU2AF1; interferon alpha-inducible of IFI6; immunoglobulin of IGKC_3, CTA_246H3.1. Thus we proposed AGR2-mediated lung adenocarcinoma metastasis novel mechanism network through repression with interferon coupling cytoskeleton to steroid metabolism-dependent humoral immune response.
authors: Biomedical Center, School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing 100876, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
authors: Juxiang
authors: J
authors: Huang
authors: Biomedical Center, School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing 100876, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. Electronic address: wanglin98@tsinghua.org.cn.
authors: Lin
authors: L
authors: Wang
authors: Lab of Computational Linguistics, School of Humanities and Social Sciences, Tsinghua University, Beijing 100084, China.
authors: Minghu
authors: M
authors: Jiang
authors: Biomedical Center, School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing 100876, China.
authors: Qingchun
authors: Q
authors: Chen
authors: School of Mechanical Electronic & Information Engineering, China University of Mining and Technology, Beijing 100083, China.
authors: Zhenfu
authors: Z
authors: Jiang
authors: Dean Department, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
authors: Haitao
authors: H
authors: Feng
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000556:secondary*; D000077192:Adenocarcinoma of Lung; D003599:Cytoskeleton; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D056724:Immunity, Humoral; D016898:Interferon-alpha / Q000276:immunology*; D008175:Lung Neoplasms / Q000235:genetics / Q000556:secondary*; D008869:Microtubule-Associated Proteins / Q000037:antagonists & inhibitors; D024101:Mitochondrial Proteins / Q000276:immunology; D009088:Mucoproteins; D009362:Neoplasm Metastasis; D015513:Oncogene Proteins; D011506:Proteins / Q000276:immunology*; D002785:Sterol O-Acyltransferase / Q000378:metabolism; D015534:Trans-Activators / Q000276:immunology; D000097587:Sterol O-Acyltransferase 2
chemical_list: D016898:Interferon-alpha; D008869:Microtubule-Associated Proteins; D024101:Mitochondrial Proteins; D009088:Mucoproteins; D015513:Oncogene Proteins; D011506:Proteins; D002785:Sterol O-Acyltransferase; D015534:Trans-Activators; D000097587:Sterol O-Acyltransferase 2; C502296:AGR2 protein, human; C468762:IFI6 protein, human; C091546:POU2AF1 protein, human
keywords: Anterior gradient homolog 2 (AGR2); Humoral immune response; Lung adenocarcinoma; Mechanism