title: Meroterpenes and azaphilones from marine mangrove endophytic fungus Penicillium 303#.
abstract: Three new metabolites (compounds 1-2 and 6), one azaphilone, and two meroterpenes, together with eleven known compounds have been isolated from a mangrove endophytic fungus, Penicillium 303#. Structure elucidation was achieved by 1D and 2D NMR spectroscopy. The absolute configurations of 1 and 2 were determined by electronic circular dichroism (ECD). Cytotoxic activities of new compounds 1-2 and 6 and compound 7were evaluated in vitro against human cancer lines MDA-MB-435, HepG2, HCT-116, and A549. Those compounds showed weak to moderate cytotoxic activities.
authors: School of Marine Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
authors: Jing
authors: J
authors: Li
authors: Department of Chemistry, College of Life Science and Technology, Jinan University, Guangzhou 510632, People's Republic of China.
authors: Xin
authors: X
authors: Yang
authors: School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, People's Republic of China.
authors: Yingying
authors: Y
authors: Lin
authors: Zhongshan Medical College, Sun Yat-sen University, Guangzhou 510800, People's Republic of China.
authors: Jie
authors: J
authors: Yuan
authors: School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, People's Republic of China.
authors: Yongjun
authors: Y
authors: Lu
authors: Zhongshan Medical College, Sun Yat-sen University, Guangzhou 510800, People's Republic of China.
authors: Xun
authors: X
authors: Zhu
authors: Zhongshan Medical College, Sun Yat-sen University, Guangzhou 510800, People's Republic of China.
authors: Jun
authors: J
authors: Li
authors: Zhongshan Medical College, Sun Yat-sen University, Guangzhou 510800, People's Republic of China.
authors: Mengfeng
authors: M
authors: Li
authors: School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, People's Republic of China.
authors: Yongcheng
authors: Y
authors: Lin
authors: School of Marine Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
authors: Jianguo
authors: J
authors: He
authors: School of Marine Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China. Electronic address: cesllan@mail.sysu.edu.cn.
authors: Lan
authors: L
authors: Liu
mesh_terms: D001578:Benzopyrans / Q000302:isolation & purification; D004354:Drug Screening Assays, Antitumor; D060026:Endophytes / Q000737:chemistry*; D045325:HCT116 Cells; D056945:Hep G2 Cells; D006801:Humans; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry*; D010860:Pigments, Biological / Q000302:isolation & purification; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification*; D053833:Wetlands
chemical_list: D001578:Benzopyrans; D010860:Pigments, Biological; D013729:Terpenes; C494154:azaphilone
keywords: Azaphilone; Cytotoxic activity; Endophytic fungus; Meroterpenes