title: T-cell lymphoblastic leukemia/lymphoma with t(7;14)(p15;q32) [TCRγ-TCL1A translocation]: a case report and a review of the literature.
abstract: A 22-year-old man sought medical advice for a swelling in the right side of the neck in December 2011. Histopathological examination of the lymph node biopsy initially suggested reactive lymphadenitis, on account of the only sparse presence of tumor cells. Bone marrow examination was performed in February 2012 revealed findings consistent with a diagnosis of T-cell lymphoblastic leukemia/lymphoma (T-LBL), and the patient was begun on remission induction therapy. The bone marrow showed an immature thymocytic pattern: cytoplasmic CD3+, surface CD3-, CD5+, CD4-, and CD8-. Re-assessment of the lymph node specimens revealed the same phenotype of the cells in the lymph node as that of the blasts in the bone marrow. In addition, a chromosomal aberration t(7;14)(p15;q32) was noted. The lymph node biopsy specimens were examined by paraffin-embedded tissue section-fluorescence in situ hybridization (PS-FISH), which revealed a fusion signal of T-cell receptor (TCR)γ gene (7p15) with T-cell leukemia/lymphoma 1A (TCL1A) gene (14q32.13). There have been at least 10 reported cases of T-LBL with t(7;14)(p15;q32), including the present case. However, this is the first reported case in which TCRγ-TCL1A translocation was confirmed by FISH.
authors: Department of Hematology, Juntendo University Urayasu Hospital Urayasu, Japan.
authors: Kei-Ji
authors: KJ
authors: Sugimoto
authors: Department of Hematology, Juntendo University Urayasu Hospital Urayasu, Japan.
authors: Asami
authors: A
authors: Shimada
authors: Department of Hematology, Juntendo University Urayasu Hospital Urayasu, Japan.
authors: Mutsumi
authors: M
authors: Wakabayashi
authors: Department of Hematology, Juntendo University Urayasu Hospital Urayasu, Japan.
authors: Yasunobu
authors: Y
authors: Sekiguchi
authors: Department of Pathology, Juntendo University Urayasu Hospital Urayasu, Japan.
authors: Hiroshi
authors: H
authors: Izumi
authors: Department of Pathology, Research Hospital, The Institute of Medical Science, The University of Tokyo Japan.
authors: Yasunori
authors: Y
authors: Ota
authors: Department of Hematology, Juntendo University School of Medicine Tokyo, Japan.
authors: Norio
authors: N
authors: Komatsu
authors: Department of Hematology, Juntendo University Urayasu Hospital Urayasu, Japan.
authors: Masaaki
authors: M
authors: Noguchi
mesh_terms: D000293:Adolescent; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics*; D001706:Biopsy; D001856:Bone Marrow Examination; D002648:Child; D002675:Child, Preschool; D002883:Chromosomes, Human, Pair 14; D002897:Chromosomes, Human, Pair 7; D005260:Female; D019675:Genes, T-Cell Receptor gamma; D020022:Genetic Predisposition to Disease; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D012074:Remission Induction; D014057:Tomography, X-Ray Computed; D014178:Translocation, Genetic; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D011518:Proto-Oncogene Proteins; C090851:TCL1A protein, human
keywords: T lymphoblastic leukemia/lymphoma; TCL1A; TCR gamma; immature thymocytic pattern; t(7;14)(p15;q32)