title: Developing a vaccine for Type 1 diabetes through targeting enteroviral infections.
abstract: Type 1 diabetes (T1D) is a chronic disease caused by the destruction of insulin producing β-cells in the pancreas. Studies carried out during the past decades have implied that enteroviruses could be an important causative agent. These findings have generated efforts aiming at developing vaccines against these viruses and testing their efficacy against T1D in clinical trials. Extensive work has been carried out to define the serotype of enteroviruses which are linked to T1D and which should be included in the vaccine, and experimental vaccines have been shown to be effective and safe in mouse models. Large-scale studies are currently in progress to increase the confidence in the scientific concept of the enterovirus-diabetes association, paralleling the efforts aimed at starting the clinical development of the vaccine. This review summarizes recent progress in this field and the scenarios regarding this development process.
authors: School of Medicine, University of Tampere, Tampere, Finland.
authors: Heikki
authors: H
authors: Hyöty
authors: Mikael
authors: M
authors: Knip
mesh_terms: D035843:Biomedical Research / Q000639:trends; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology* / Q000517:prevention & control*; D055808:Drug Discovery / Q000639:trends; D004769:Enterovirus Infections / Q000150:complications* / Q000517:prevention & control*; D006801:Humans; D014765:Viral Vaccines / Q000276:immunology* / Q000302:isolation & purification*
chemical_list: D014765:Viral Vaccines
keywords: Type 1 diabetes; antiviral drugs; enterovirus; vaccine