title: Supermolecular evodiamine loaded water-in-oil nanoemulsions: enhanced physicochemical and biological characteristics.
abstract: The purpose of this study was to develop and evaluate the supermolecular evodiamine (EVO) loaded water-in-oil nanoemulsions containing brucea javanica oil (NESEB) with enhanced physicochemical and biological characteristics. NESEB was fabricated by applying supermolecular phytosome nanotechnology and nanoemulsification technology together, in addition to using synergistic plant essential oil as a basic composition. Preferred physicochemical and biological characteristics of NESEB were investigated and compared with free EVO and other nanoemulsive EVO carriers. The possible explanations for improved absorption and bioavailability were put forward here. NESEB had high absorption and bioavailability, for example: the absorption rate constants and permeabilities of NESEB in different intestinal segments were 3.65-6.76 times that of free EVO; the relative bioavailability of NESEB to free EVO was 846.97%. NESEB markedly improved the oral bioavailability of EVO, which was most likely due to the increased gastrointestinal absorption. The development of nanoemulsion-based supermolecular EVO nanocarriers provides valuable tactics in insoluble natural antitumor drug delivering.
authors: Medicine Engineering Research Center, Chongqing Key Laboratory of Biochemical & Molecular Pharmacology, Chongqing Medical University, Chongqing, People's Republic of China.
authors: Jiangbo
authors: J
authors: Hu
authors: Medicine Engineering Research Center, Chongqing Key Laboratory of Biochemical & Molecular Pharmacology, Chongqing Medical University, Chongqing, People's Republic of China.
authors: Lili
authors: L
authors: Sun
authors: Medicine Engineering Research Center, Chongqing Key Laboratory of Biochemical & Molecular Pharmacology, Chongqing Medical University, Chongqing, People's Republic of China.
authors: Dezhang
authors: D
authors: Zhao
authors: Medicine Engineering Research Center, Chongqing Key Laboratory of Biochemical & Molecular Pharmacology, Chongqing Medical University, Chongqing, People's Republic of China.
authors: Liangke
authors: L
authors: Zhang
authors: Department of Health Statistics, College of Public Health, Chongqing Medical University, Chongqing, People's Republic of China.
authors: Mengliang
authors: M
authors: Ye
authors: Department of Thoracic Surgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People's Republic of China.
authors: Qunyou
authors: Q
authors: Tan
authors: Department of Thoracic Surgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People's Republic of China.
authors: Chunshu
authors: C
authors: Fang
authors: Medicine Engineering Research Center, Chongqing Key Laboratory of Biochemical & Molecular Pharmacology, Chongqing Medical University, Chongqing, People's Republic of China.
authors: Hong
authors: H
authors: Wang
authors: Medicine Engineering Research Center, Chongqing Key Laboratory of Biochemical & Molecular Pharmacology, Chongqing Medical University, Chongqing, People's Republic of China. Electronic address: 13308300303@163.com.
authors: Jingqing
authors: J
authors: Zhang
mesh_terms: D001682:Biological Availability; D004655:Emulsions; D041981:Gastrointestinal Tract / Q000378:metabolism; D007700:Kinetics; D009821:Oils / Q000737:chemistry*; D010539:Permeability; D011799:Quinazolines / Q000737:chemistry* / Q000493:pharmacokinetics; D014867:Water / Q000737:chemistry*
chemical_list: D004655:Emulsions; D009821:Oils; D011799:Quinazolines; D014867:Water; C049639:evodiamine
keywords: Absorption; Brucea javanica oil; Characteristics; Nanoemulsification; Oral bioavailability; Supermolecular evodiamine