title: Genomic characterization of acute leukemias.
abstract: Over the past two decades, hematologic malignancies have been extensively evaluated due to the introduction of powerful technologies, such as conventional karyotyping, FISH analysis, gene and microRNA expression profiling, array comparative genomic hybridization and SNP arrays, and next-generation sequencing (including whole-exome sequencing and RNA-seq). These analyses have allowed for the refinement of the mechanisms underlying the leukemic transformation in several oncohematologic disorders and, more importantly, they have permitted the definition of novel prognostic algorithms aimed at stratifying patients at the onset of disease and, consequently, treating them in the most appropriate manner. Furthermore, the identification of specific molecular markers is opening the door to targeted and personalized medicine. The most important findings on novel acquisitions in the context of acute lymphoblastic leukemia of both B and T lineage and de novo acute myeloid leukemia are described in this review.
authors: Division of Hematology, Department of Cellular Biotechnologies and Hematology, Sapienza University of Rome, Rome, Italy.
authors: Sabina
authors: S
authors: Chiaretti
authors: Valentina
authors: V
authors: Gianfelici
authors: Giulia
authors: G
authors: Ceglie
authors: Robin
authors: R
authors: Foà
mesh_terms: D000208:Acute Disease; D000367:Age Factors; D055028:Comparative Genomic Hybridization; D020869:Gene Expression Profiling; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000235:genetics*; D015470:Leukemia, Myeloid, Acute / Q000235:genetics; D035683:MicroRNAs; D009154:Mutation; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics; D012737:Sex Factors
chemical_list: D035683:MicroRNAs