title: The clinical profile, management, and overall outcome of aneurysmal subarachnoid hemorrhage at the neurosurgical unit of a tertiary care center in India.
abstract: OBJECTIVE
  Several studies report good outcomes in selected patients of aneurysmal subarachnoid hemorrhage (aSAH). The purpose of our study is to project the clinical characteristics, management, and overall outcome of patients with aSAH presenting to a tertiary care center in India.
  
  
  METHODS
  A prospective study was conducted over a period of 10 months and all patients presenting with aSAH were studied. Patients presenting in all grades and managed with any type of intervention or managed conservatively were included to characterize their clinical and radiological profile at admission, during management, and at discharge. Outcome was assessed with the Glasgow Outcome Score (GOS) at 3 months follow-up.
  
  
  RESULTS
  Out of the 482 patients [mean age: 51.3 (±13.5); M: F = 1:1], 330 patients were fit to be taken up for intervention of the ruptured aneurysm, while 152 patients were unfit for any intervention. At 3 months follow-up, good outcome (GOS 4 and 5) was observed in 159 (33%), poor outcome (GOS 2 and 3) in 53 (11%), and death in 219 (45.4%) patients, while 51 patients (10.6%) were lost to follow-up. Most (95%) of the patients in the non-intervention group expired, and hence the high mortality rate, as we have analyzed the results of all patients of all grades, regardless of the treatment given. The predictors of poor outcome (GOS 1, 2, and 3) at 3 months follow-up, using multinomial regression model, were: World Federation of Neurological Surgeons (WFNS) grade IV and V (at admission and after adequate resuscitation) [odds ratio (OR): 35.1, 95% confidence interval (CI): 10.8-114.7] and presence of hypertension as a co-morbid illness [OR: 2.7, 95% CI: 1.6-5.6]. All patients showing acute infarction on computed tomography scan at presentation had a poor outcome.
  
  
  CONCLUSIONS
  Despite recent advances in the treatment of patients with aSAH, the morbidity and mortality rates have failed to improve significantly in unselected patients and natural cohorts. This may be attributed to the natural history of aSAH, and calls for new strategies to diagnose and treat such patients before the catastrophe strikes.
authors: Department of Neurosurgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
authors: Harsimrat Bir Singh
authors: HB
authors: Sodhi
authors: Department of Neurosurgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
authors: Amey R
authors: AR
authors: Savardekar
authors: Department of Neurosurgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
authors: Sandeep
authors: S
authors: Mohindra
authors: Department of Neurosurgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
authors: Rajesh
authors: R
authors: Chhabra
authors: Department of Radio-Diagnosis, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
authors: Vivek
authors: V
authors: Gupta
authors: Department of Neurosurgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
authors: Sunil K
authors: SK
authors: Gupta
keywords: Intracranial aneurysm; overall outcome; subarachnoid hemorrhage