title: A novel chromosomal abnormality t (9;14)(p24;q13) in B-acute lymphoblastic leukemia.
abstract: Acute lymphoblastic leukemia is a malignant disease of the bone marrow in which early lymphoid precursors proliferate and replace the normal hematopoietic cells of the marrow. We describe the clinical, morphologic, immunophenotypic and cytogenetic findings in the case of a 26-year-old man with B-lymphoblastic leukemia. Surface marker analysis revealed that they are positive for CD markers CD10, CD19, CD13, CD34, CD45 and HLA-DR, but negative for CD20, CD33, CD117 and CD11C markers. Cytogenetic analysis established a novel translocation, t (9;14)(p24;q13). Apart from this, spectral karyotyping revealed an additional translocation, t (6p; 14q). This is the first documented case of B-lymphoblastic leukemia with concurrent occurrence of both abnormalities. Further studies are needed to understand the role of this abnormality in carcinogenesis.
authors: Division of Cancer Research, Regional Cancer Centre, Medical College, Trivandrum, Kerala, India.
authors: Sureshkumar
authors: S
authors: Raveendran
authors: Division of Cancer Research, Regional Cancer Centre, Medical College, Trivandrum, Kerala, India.
authors: Santhi
authors: S
authors: Sarojam
authors: Division of Medical Oncology, Regional Cancer Centre, Medical College, Trivandrum, Kerala, India.
authors: Geetha
authors: G
authors: Narayanan
authors: Division of Cancer Research, Regional Cancer Centre, Medical College, Trivandrum, Kerala, India.
authors: Hariharan
authors: H
authors: Sreedharan
keywords: B-acute lymphoblastic leukemia; Janus kinase 2; conventional cytogenetics; spectral karyotyping