title: [The immunologic function and role of allograft inflammatory factor-1].
abstract: Allograft inflammatory factor-1 is the protein that expressed in the macrophages around the coronary arteries in rat ectopic cardiac allograft model. AIF-1 is produced mainly by macrophages and regulated by interferon-gamma (IFN-γ). There are various splicing valiants in AIF-1, and the functions are different. AIF-1 has Ca-binding EF-hand motif that induces cell proliferation and migration by structural features. Besides cell proliferation and migration, AIF-1 contributes to secretion of inflammatory cytokines and chemokines such as IL-6, IL-10, IL-12, and transforming growth factor-beta (TGF-β), insulin resistance by downregulation of GLUT4 or IRS-1, and fibrosis process by upregulation of collagen production. It has been elucidated that AIF-1 is responsible for the onset of various diseases such as rheumatoid arthritis and systemic sclerosis, atherosclerotic disease, diabetes mellitus. AIF-1 may have the therapeutic potential for chronic inflammatory diseases by elucidation of the mechanism.
authors: Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine.
authors: Aihiro
authors: A
authors: Yamamoto
authors: Yutaka
authors: Y
authors: Kawahito
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology; D049109:Cell Proliferation; D004268:DNA-Binding Proteins / Q000276:immunology*; D006801:Humans; D016350:Leucine Zippers; D009687:Nuclear Proteins / Q000276:immunology; D012595:Scleroderma, Systemic / Q000276:immunology
chemical_list: D004268:DNA-Binding Proteins; D009687:Nuclear Proteins