title: Ectosomes: a new mechanism for non-exosomal secretion of tau protein.
abstract: Tau is a microtubule-associated protein that aggregates in neurodegenerative disorders known as tauopathies. Recently, studies have suggested that Tau may be secreted and play a role in neural network signalling. However, once deregulated, secreted Tau may also participate in the spreading of Tau pathology in hierarchical pathways of neurodegeneration. The mechanisms underlying neuron-to-neuron Tau transfer are still unknown; given the known role of extra-cellular vesicles in cell-to-cell communication, we wondered whether these vesicles could carry secreted Tau. We found, among vesicles, that Tau is predominately secreted in ectosomes, which are plasma membrane-originating vesicles, and when it accumulates, the exosomal pathway is activated.
authors: Inserm, UMR837, Lille, France; Université de Lille, Faculté de Médecine, IMPRT, JPARC, Lille, France.
authors: Simon
authors: S
authors: Dujardin
authors: Inserm, UMR837, Lille, France; Université de Lille, Faculté de Médecine, IMPRT, JPARC, Lille, France.
authors: Séverine
authors: S
authors: Bégard
authors: Inserm, UMR837, Lille, France; Université de Lille, Faculté de Médecine, IMPRT, JPARC, Lille, France.
authors: Raphaëlle
authors: R
authors: Caillierez
authors: Inserm, UMR837, Lille, France; Université de Lille, Faculté de Médecine, IMPRT, JPARC, Lille, France.
authors: Cédrick
authors: C
authors: Lachaud
authors: Inserm, UMR837, Lille, France; Université de Lille, Faculté de Médecine, IMPRT, JPARC, Lille, France.
authors: Lucie
authors: L
authors: Delattre
authors: Inserm, UMR837, Lille, France; Université de Lille, Faculté de Médecine, IMPRT, JPARC, Lille, France.
authors: Sébastien
authors: S
authors: Carrier
authors: Inserm, UMR837, Lille, France; Université de Lille, Faculté de Médecine, IMPRT, JPARC, Lille, France.
authors: Anne
authors: A
authors: Loyens
authors: Inserm, UMR837, Lille, France; Université de Lille, Faculté de Médecine, IMPRT, JPARC, Lille, France; CMRR, CHR, Lille, France.
authors: Marie-Christine
authors: MC
authors: Galas
authors: Laboratoire d'Enzymologie et Biochimie Structurales, UPR 3082 CNRS, Gif-sur-Yvette, France.
authors: Luc
authors: L
authors: Bousset
authors: Laboratoire d'Enzymologie et Biochimie Structurales, UPR 3082 CNRS, Gif-sur-Yvette, France.
authors: Ronald
authors: R
authors: Melki
authors: Atomic Energy Commission (CEA), Institute of Biomedical Imaging (I2BM), Molecular Imaging Research Center (MIRCen), Fontenay-aux-Roses, France; CNRS, URA2210, Molecular Imaging Research Center (MIRCen), Fontenay-aux-Roses, France.
authors: Gwennaëlle
authors: G
authors: Aurégan
authors: Atomic Energy Commission (CEA), Institute of Biomedical Imaging (I2BM), Molecular Imaging Research Center (MIRCen), Fontenay-aux-Roses, France; CNRS, URA2210, Molecular Imaging Research Center (MIRCen), Fontenay-aux-Roses, France.
authors: Philippe
authors: P
authors: Hantraye
authors: Atomic Energy Commission (CEA), Institute of Biomedical Imaging (I2BM), Molecular Imaging Research Center (MIRCen), Fontenay-aux-Roses, France; CNRS, URA2210, Molecular Imaging Research Center (MIRCen), Fontenay-aux-Roses, France.
authors: Emmanuel
authors: E
authors: Brouillet
authors: Inserm, UMR837, Lille, France; Université de Lille, Faculté de Médecine, IMPRT, JPARC, Lille, France; CMRR, CHR, Lille, France.
authors: Luc
authors: L
authors: Buée
authors: Inserm, UMR837, Lille, France; Université de Lille, Faculté de Médecine, IMPRT, JPARC, Lille, France; CMRR, CHR, Lille, France.
authors: Morvane
authors: M
authors: Colin
mesh_terms: D000818:Animals; D055252:Cell-Derived Microparticles / Q000378:metabolism*; D002478:Cells, Cultured; D004622:Embryo, Mammalian / Q000166:cytology; D055354:Exosomes / Q000378:metabolism; D045604:Extracellular Fluid / Q000378:metabolism; D006801:Humans; D008854:Microscopy, Electron; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D016875:tau Proteins