title: [Seven cases of port-a-cath contamination caused by Pantoea agglomerans in the Oncological Service of Iseo Hospital, Brescia (Italy)].
abstract: Pantoea agglomerans, a gram negative bacillus in the Enterobacteriaceae family, has been isolated from feculent material, plants and soil. Soft tissue and bone-joint infections due to P. agglomerans following penetrating trauma by vegetation and bacteraemia in association with intravenous fluid, total parenteral nutrition, blood products and anaesthetic agent contamination have been reported. Between October 2009 and January 2010 seven cases of port a cath contamination caused by P. agglomerans were observed in the Oncological Service of our hospital. All patients presented with septic fever after heparinization of the central venous catheter. 5/7 patients were female; mean age was 67 years (range 58-75). 6/7 patients were affected by colorectal adenocarcinoma, 1/7 by mammarian cancer. Mean time from CVC insertion was 23.8 months (range 13-42) at the time of fever. In three cases, port a cath was removed following the oncologist prescription. P. agglomerans was isolated from the catheter tip in one case and from CVC blood culture in 6-7 cases. In all cases peripheral blood cultures were negative. Patients were treated with ciprofloxacin lock therapy and systemic therapy (per os), obtaining negative cultures from port a cath. Notwithstanding the absence of isolation of Pantoea strains from environmental cultures, after educational intervention, which underlined some faulty procedures in CVC management, no further cases were observed.
authors: UOSC Medicina Generale; Gruppo operativo per il controllo delle infezioni ospedaliere; UOSD Oncologia; UOSC Laboratorio analisi, AO Mellino Mellini, Chiari (BS), Italy.
authors: Ilaria
authors: I
authors: Izzo
authors: UOSC Medicina Generale; Gruppo operativo per il controllo delle infezioni ospedaliere; UOSD Oncologia; UOSC Laboratorio analisi, AO Mellino Mellini, Chiari (BS), Italy.
authors: Donatella
authors: D
authors: Lania
authors: UOSC Medicina Generale; Gruppo operativo per il controllo delle infezioni ospedaliere; UOSD Oncologia; UOSC Laboratorio analisi, AO Mellino Mellini, Chiari (BS), Italy.
authors: Antonino
authors: A
authors: Castro
authors: UOSC Medicina Generale; Gruppo operativo per il controllo delle infezioni ospedaliere; UOSD Oncologia; UOSC Laboratorio analisi, AO Mellino Mellini, Chiari (BS), Italy.
authors: Fernanda
authors: F
authors: Lanzini
authors: UOSC Medicina Generale; Gruppo operativo per il controllo delle infezioni ospedaliere; UOSD Oncologia; UOSC Laboratorio analisi, AO Mellino Mellini, Chiari (BS), Italy.
authors: Daniele
authors: D
authors: Bella
authors: UOSC Medicina Generale; Gruppo operativo per il controllo delle infezioni ospedaliere; UOSD Oncologia; UOSC Laboratorio analisi, AO Mellino Mellini, Chiari (BS), Italy.
authors: Adriano
authors: A
authors: Pagani
authors: UOSC Medicina Generale; Gruppo operativo per il controllo delle infezioni ospedaliere; UOSD Oncologia; UOSC Laboratorio analisi, AO Mellino Mellini, Chiari (BS), Italy.
authors: Paolo
authors: P
authors: Colombini
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage; D055499:Catheter-Related Infections / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D002939:Ciprofloxacin / Q000627:therapeutic use; D003428:Cross Infection / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D004756:Enterobacteriaceae Infections / Q000150:complications*; D005260:Female; D006761:Hospitals; D006801:Humans; D007558:Italy; D008297:Male; D008495:Medical Oncology; D008875:Middle Aged; D020636:Pantoea / Q000302:isolation & purification* / Q000472:pathogenicity; D012189:Retrospective Studies; D016896:Treatment Outcome; D062666:Vascular Access Devices / Q000009:adverse effects*
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D002939:Ciprofloxacin