title: Cardiac 123I-MIBG uptake in de novo Brazilian patients with Parkinson's disease without clinically defined dysautonomia.
abstract: Myocardial scintigraphy with meta-iodo-benzyl-guanidine (123I cMIBG) has been studied in Parkinson's disease (PD), especially in Asian countries, but not in Latin America. Most of these studies include individuals with PD associated to a defined dysautonomia. Our goal is to report the cardiac sympathetic neurotransmission in de novo Brazilian patients with sporadic PD, without clinically defined dysautonomia. We evaluated retrospectively a series of 21 consecutive cases with PD without symptoms or signs of dysautonomia assessed by the standard bedside tests. This number was reduced to 14 with the application of exclusion criteria. 123I cMIBG SPECT up-take was low or absent in all of them and the heart/mediastinum ratio was low in 12 of 14. We concluded that 123I cMIBG has been able to identify cardiac sympathetic neurotransmission disorder in Brazilian de novo PD patients without clinically defined dysautonomia.
authors: Departamento de Neurologia, Hospital Universitário Antonio Pedro, Universidade Federal Fluminense, Niterói, RJ, Brazil.
authors: Marco Antonio Araujo
authors: MA
authors: Leite
authors: Departamento de Neurologia, Hospital Universitário Antonio Pedro, Universidade Federal Fluminense, Niterói, RJ, Brazil.
authors: Osvaldo J M
authors: OJ
authors: Nascimento
authors: Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors: João Santos
authors: JS
authors: Pereira
authors: Departamento de Neurologia, Hospital Universitário Antonio Pedro, Universidade Federal Fluminense, Niterói, RJ, Brazil.
authors: Clayton
authors: C
authors: Amaral
authors: Departamento de Medicina Nuclear, Hospital Universitário Antonio Pedro, Universidade Federal Fluminense, Niterói, RJ, Brazil.
authors: Cláudio T
authors: CT
authors: Mesquita
authors: Departamento de Medicina Nuclear, Hospital Universitário Antonio Pedro, Universidade Federal Fluminense, Niterói, RJ, Brazil.
authors: Jader C
authors: JC
authors: Azevedo
authors: Hospital Barra D?Or, Rio de Janeiro, RJ, Brazil.
authors: Adriana S X de
authors: AS
authors: Brito
authors: Clínica de Medicina Nuclear Villela Pedras, Rio de Janeiro, RJ, Brazil.
authors: Felipe Villela
authors: FV
authors: Pedras
mesh_terms: D019797:3-Iodobenzylguanidine; D000368:Aged; D001938:Brazil; D016009:Chi-Square Distribution; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D010300:Parkinson Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology; D019275:Radiopharmaceuticals; D012016:Reference Values; D015203:Reproducibility of Results; D012189:Retrospective Studies; D009435:Synaptic Transmission / Q000502:physiology*; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
chemical_list: D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine