title: Fetal intracranial hemorrhage related to maternal autoimmune thrombocytopenic purpura.
abstract: BACKGROUND
  Maternal autoimmune thrombocytopenic purpura (AITP) can cause fetal intracranial hemorrhage.
  
  
  METHODS
  A 19-year-old primigravida was referred to our institution for prenatally detected ventriculomegaly at 30th week of gestation. Her personal and family histories were unremarkable. Her platelet count was 54 × 109/L. Fetal neurosonography showed intraparenchymal hemorrhage. AITP was diagnosed in the mother and platelet count decreased at 34 × 109/L. Patient was treated with methylprednisolone and intravenous immunoglobulin. She delivered a 2,340-g infant at 37 weeks with elective cesarean section. The platelet count of the newborn was 181 × 109/L and coagulation tests were normal. No antiplatelet specific antibodies were detected in cord blood. Postnatal MRI evaluation confirmed grade IV intracranial hemorrhage. The newborn baby has suffered from mild spasticity and seizures.
  
  
  CONCLUSIONS
  Clinicians must be vigilant about the catastrophic fetal complications of maternal AITP; a close follow-up with a multidisciplinary cooperation between obstetricians, hematologists, and neonatologists must be warranted.
authors: Division of Perinatalogy, Faculty of Medicine, Department of Obstetrics and Gynecology, Erciyes University, Kayseri, Turkey.
authors: Mehmet Serdar
authors: MS
authors: Kutuk
authors: Laure
authors: L
authors: Croisille
authors: Sureyya Burcu
authors: SB
authors: Gorkem
authors: Ebru
authors: E
authors: Yilmaz
authors: Levent
authors: L
authors: Korkmaz
authors: Philippe
authors: P
authors: Bierling
authors: Ekrem
authors: E
authors: Unal
mesh_terms: D002585:Cesarean Section; D003299:Cooperative Behavior; D004453:Echoencephalography; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D007116:Immunization, Passive; D007231:Infant, Newborn; D033183:Interdisciplinary Communication; D020300:Intracranial Hemorrhages / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D010976:Platelet Count; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000175:diagnosis* / Q000628:therapy; D011263:Pregnancy Trimester, Third; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000175:diagnosis* / Q000628:therapy; D016216:Ultrasonography, Prenatal; D055815:Young Adult
chemical_list: D008775:Methylprednisolone