title: Mass spectrometry for the study of autism and neurodevelopmental disorders.
abstract: Mass spectrometry (MS) has been increasingly used to study central nervous system disorders, including autism spectrum disorders (ASDs). The first studies of ASD using MS focused on the identification of external toxins, but current research is more directed at understanding endogenous protein changes that occur in ASD (ASD proteomics). This chapter focuses on how MS has been used to study ASDs, with particular focus on proteomic analysis. Other neurodevelopmental disorders have been investigated using this technique, including genetic syndromes associated with autism such as fragile X syndrome and Smith-Lemli-Opitz syndrome.
authors: Biochemistry & Proteomics Group, Department of Chemistry & Biomolecular Science, Clarkson University, 8 Clarkson Avenue, Potsdam, NY, 13699-5810, USA.
authors: Armand G
authors: AG
authors: Ngounou Wetie
authors: Robert M
authors: RM
authors: Dekroon
authors: Mihaela
authors: M
authors: Mocanu
authors: Jeanne P
authors: JP
authors: Ryan
authors: Costel C
authors: CC
authors: Darie
authors: Alisa G
authors: AG
authors: Woods
mesh_terms: D000818:Animals; D001321:Autistic Disorder / Q000378:metabolism*; D005600:Fragile X Syndrome / Q000378:metabolism*; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods*; D040901:Proteomics / Q000379:methods*; D019082:Smith-Lemli-Opitz Syndrome / Q000378:metabolism*