title: Copper mediated neurological disorder: visions into amyotrophic lateral sclerosis, Alzheimer and Menkes disease.
abstract: Copper (Cu) is a vital redox dynamic metal that is possibly poisonous in superfluous. Metals can traditionally or intricately cause propagation in reactive oxygen species (ROS) accretion in cells and this may effect in programmed cell death. Accumulation of Cu causes necrosis that looks to be facilitated by DNA damage, followed by activation of P53. Cu dyshomeostasis has also been concerned in neurodegenerative disorders such as Alzheimer, Amyotrophic lateral sclerosis (ALS) or Menkes disease and is directly related to neurodegenerative syndrome that usually produces senile dementia. These mortal syndromes are closely related with an immense damage of neurons and synaptic failure in the brain. This review focuses on copper mediated neurological disorders with insights into amyotrophic lateral sclerosis, Alzheimer and Menkes disease.
authors: Department of Biotechnology, NIMS University, Jaipur, India. Electronic address: anami.genetics@gmail.com.
authors: Anami
authors: A
authors: Ahuja
authors: Faculty of Medicine in Hradec Kralove, University of Charles, Prague, Czech Republic.
authors: Kapil
authors: K
authors: Dev
authors: Department of Biotechnology, N.C. College of Engineering, Israna, India.
authors: Ranjeet S
authors: RS
authors: Tanwar
authors: Department of Biotechnology, Deenbandhu Chotu Ram University of Science and Technology, Murthal, India.
authors: Krishan K
authors: KK
authors: Selwal
authors: Department of Biotechnology, Meerut Institute of Engineering and Technology, Meerut, India.
authors: Pankaj K
authors: PK
authors: Tyagi
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology* / Q000473:pathology; D000690:Amyotrophic Lateral Sclerosis / Q000209:etiology* / Q000473:pathology; D001921:Brain / Q000378:metabolism / Q000473:pathology; D003300:Copper / Q000009:adverse effects*; D006801:Humans; D007706:Menkes Kinky Hair Syndrome / Q000209:etiology* / Q000473:pathology; D018384:Oxidative Stress
chemical_list: D003300:Copper
keywords: Alzheimer disease; Amyotrophic lateral sclerosis; Copper; Menkes disease; Neurological disorders