title: Structure-based drug design: NMR-based approach for ligand-protein interactions.
abstract: The realization of the powerfulness in analyzing ligand-protein interactions at the atomic resolution has made NMR techniques increasingly attractive in drug discovery and development. With some significant new method developments during the past few years, NMR-based approaches will undoubtedly be helpful in high throughput screening and in providing structural and interaction information beneficial for new drug developments. Here in this review, instead of providing an exhaustive account of applications of NMR, we will seek to highlight some key points related to the solution state NMR methods for extracting information from both ligands and proteins.:
authors: State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Centre for Magnetic Resonance, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, 430071, PR China.
authors: Xu
authors: X
authors: Zhang
authors: State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Centre for Magnetic Resonance, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, 430071, PR China. Electronic address:Huiru.tang@wipm.ac.cn.
authors: Huiru
authors: H
authors: Tang
authors: State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Centre for Magnetic Resonance, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, 430071, PR China.
authors: Chaohui
authors: C
authors: Ye
authors: State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Centre for Magnetic Resonance, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, 430071, PR China. Electronic address:ml.liu@wipm.ac.cn.
authors: Maili
authors: M
authors: Liu