title: Tapping, pulling, probing: atomic force microscopy in drug discovery.
abstract: The atomic force microscope is a versatile instrument that can image surfaces with nanoscale resolution, probe local mechanical properties, and measure a variety of interaction forces. It can be relatively easily operated in fluids, and thus experiments can be conducted under nearly physiological conditions, which is behind its numerous applications in biological problems. In the field of drug discovery, atomic force microscopy (AFM) presents a unique opportunity to study a variety of phenomena at the cellular and subcellular level, down to individual (macro)molecular complexes.:
authors: Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA.
authors: Justin
authors: J
authors: Legleiter
authors: Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA. Electronic address:tomek@andrew.cmu.edu.
authors: Tomasz
authors: T
authors: Kowalewski