title: Glycerin suppository for promoting feeding tolerance in preterm very low birthweight neonates: a randomized controlled trial.
abstract: OBJECTIVE
  To compare the efficacy of glycerin suppository versus no suppository in preterm very-low-birthweight neonates for improving feeding tolerance.
  
  
  METHODS
  Randomized controlled trial.
  
  
  METHODS
  Level III neonatal unit from Mumbai, India.
  
  
  METHODS
  50 very-low-birthweight (birth weight between 1000 to 1500 grams)preterm (gestational age between 28 to 32 weeks) neonates randomized to glycerine suppository (n=25) or no intervention (n=26).
  
  
  METHODS
  Glycerin suppository (1g) once a day from day-2 to day-14 of life or no suppository, along with intermittent oral feeds and standardized care.
  
  
  METHODS
  Time required to achieve full enteral feeds (180 mL/kg/d).
  
  
  RESULTS
  Baseline characteristics of neonates like gestational age, birthweight, gender and age at the time of introduction of feeds were comparable in both groups. The mean (SD) duration to reach full enteral feed was 11.90 (3.1) days in glycerin suppository group and was not significantly different (P=0.58) from control group, [11.33 (3.57) days]. Glycerin suppository group regained birth weight 2 days earlier than control group but this difference was not significant (P=0.16). There was no significant difference in duration of hospital stay or occurrence of necrotizing enterocolitis amongst the two study groups.
  
  
  CONCLUSIONS
  Once daily application of glycerin suppository does not accelerate the achievement of full feeds in preterm very-low-birthweight neonates.
authors: Department of Neonatology, Surya Childrens Hospital, Santacruz West, Mumbai, India. Correspondence to: Dr Nandkishor S Kabra, Department of Neonatology, Surya Childrens Hospital, Mangal Ashirwad, Junction of S V Road and Dattatraya Road, Santacruz West, Mumbai 400054 India. nskabra@gmail.com.
authors: Suvarna
authors: S
authors: Shinde
authors: Nandkishor S
authors: NS
authors: Kabra
authors: Shobha R
authors: SR
authors: Sharma
authors: Bhupendra S
authors: BS
authors: Avasthi
authors: Javed
authors: J
authors: Ahmed
mesh_terms: D001724:Birth Weight / Q000502:physiology; D004750:Enteral Nutrition / Q000706:statistics & numerical data*; D005260:Female; D005990:Glycerol / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D054368:Laxatives / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male
chemical_list: D054368:Laxatives; D005990:Glycerol