title: Effects of treatment with bimatoprost 0.03% for 3 years in patients with normal-tension glaucoma.
abstract: OBJECTIVE
  To evaluate the effects of bimatoprost 0.03% single treatment for 3 years on intraocular pressure (IOP) and visual field performance.
  
  
  METHODS
  We monitored the IOP of 62 patients with normal-tension glaucoma every 1-3 months. The Humphrey visual field test was performed every 6 months after treatment and the results obtained were compared to those before treatment. In addition, visual field performance was evaluated using trend and event analysis.
  
  
  RESULTS
  The mean ± standard deviation (SD) of IOP after treatment with bimatoprost for 3 years (13.6±3.1 mmHg) was significantly lower than that before treatment (16.8±2.4 mmHg, P<0.0001). No change was observed in the mean deviation and pattern SD values of the Humphrey visual field before and 3 years after treatment. Worsening of visual field performance was observed in one patient (3.0%) by using trend analysis and in four patients (12.1%) by using event analysis. Treatment was discontinued in 17 patients (27.4%) because of adverse reactions.
  
  
  CONCLUSIONS
  Bimatoprost 0.03% single treatment was effective in reducing the IOP at least during the 3 years of treatment, but visual field performance worsened by 3.0%-12.1% in patients with normal-tension glaucoma.
authors: Inouye Eye Hospital, Tokyo, Japan.
authors: Kenji
authors: K
authors: Inoue
authors: Inouye Eye Hospital, Tokyo, Japan.
authors: Minako
authors: M
authors: Shiokawa
authors: Inouye Eye Hospital, Tokyo, Japan.
authors: Takayuki
authors: T
authors: Fujimoto
authors: 2nd Department of Ophthalmology, Toho University School of Medicine, Tokyo, Japan.
authors: Goji
authors: G
authors: Tomita
keywords: IOP; event analysis; trend analysis; visual field