title: Effectively designed molecularly imprinted polymers for selective extraction of glabridin from Glycyrrhiza glabra L. residues by screening the library of non-imprinted polymers.
abstract: Molecularly imprinted polymers (MIPs) with high selectivity and affinity to glabridin were designed based on the screening results of the library of non-imprinted polymers (NIPs). The NIP library contained 48 polymers that were polymerized with the combinations of different functional monomers, cross-linkers, and porogenic solvents. The distribution coefficient (k) values were used to estimate the affinity of NIPs to glabridin. The corresponding MIPs of the best three NIPs were prepared. After evaluating the imprinting effects and selectivity of the three MIPs, the performance of the best MIP as solid phase extraction sorbent was investigated. Glabridin with percent recovery of 83 was obtained from the extract of Glycyrrhiza glabra L. (G. glabra L.) residues by molecularly imprinted solid phase extraction (MISPE). Thus, this material can be successfully used for the extraction and purification of glabridin from G. glabra L. residues.
authors: Shandong Analysis and Test Center, Shandong Academy of Sciences, Jinan 250014, China; College of Food Science and Engineering, Shandong Agricultural University, Taian, China.
authors: Lingxiao
authors: L
authors: Chen
authors: Shandong Analysis and Test Center, Shandong Academy of Sciences, Jinan 250014, China.
authors: Wenhua
authors: W
authors: Ji
authors: Shandong Analysis and Test Center, Shandong Academy of Sciences, Jinan 250014, China.
authors: Wenjuan
authors: W
authors: Duan
authors: Shandong Analysis and Test Center, Shandong Academy of Sciences, Jinan 250014, China; College of Food Science and Engineering, Shandong Agricultural University, Taian, China. Electronic address: wangx@sdas.org.
authors: Xiao
authors: X
authors: Wang
authors: Shandong Analysis and Test Center, Shandong Academy of Sciences, Jinan 250014, China.
authors: Qianshan
authors: Q
authors: Gao
authors: Shandong Analysis and Test Center, Shandong Academy of Sciences, Jinan 250014, China.
authors: Yanling
authors: Y
authors: Geng
authors: National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. Electronic address: luqihuang@126.com.
authors: Luqi
authors: L
authors: Huang
mesh_terms: D000327:Adsorption; D006035:Glycyrrhiza / Q000737:chemistry*; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification*; D000432:Methanol; D054802:Molecular Imprinting / Q000379:methods*; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification*; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D054852:Small Molecule Libraries; D052616:Solid Phase Extraction
chemical_list: D007529:Isoflavones; D010636:Phenols; D010936:Plant Extracts; D011108:Polymers; D054852:Small Molecule Libraries; C107601:glabridin; D000432:Methanol
keywords: Adsorption; Glabridin; Imprinting; Polymer; Polymer screening