title: From genes to drugs: target validation in Caenorhabditis elegans.
abstract: A central challenge in post-genomic drug discovery is selection of relevant therapeutic targets from a large pool of candidates, so that resources are invested productively. Key to meeting this challenge is demonstrating target function in disease-related pathways in vivo. The nematode Caenorhabditis elegans, a well-characterized experimental system for genetic analysis of biological regulatory pathways, provides a powerful means of assessing the impact of modulating target function on biological processes, thus facilitating selection of high-value targets.:
authors: Cambria Biosciences LLC, 8A Henshaw St., Woburn, MA 01801, USA. Electronic address:asluder@cambriabio.com.
authors: Ann E
authors: AE
authors: Sluder
authors: Bio3/Bioinformatics and Molecular Genetics, University of Freiburg, Schaenzlestr. 1, D-79104 Freiburg, Germany.
authors: Ralf
authors: R
authors: Baumeister