title: Genome typing of nonhuman primate models: implications for biomedical research.
abstract: The success of personalized medicine rests on understanding the genetic variation between individuals. Thus, as medical practice evolves and variation among individuals becomes a fundamental aspect of clinical medicine, a thorough consideration of the genetic and genomic information concerning the animals used as models in biomedical research also becomes critical. In particular, nonhuman primates (NHPs) offer great promise as models for many aspects of human health and disease. These are outbred species exhibiting substantial levels of genetic variation; however, understanding of the contribution of this variation to phenotypes is lagging behind in NHP species. Thus, there is a pivotal need to address this gap and define strategies for characterizing both genomic content and variability within primate models of human disease. Here, we discuss the current state of genomics of NHP models and offer guidelines for future work to ensure continued improvement and utility of this line of biomedical research.
authors: EUPRIM-Net, Research Coordination, German Primate Center, Leibniz Institute for Primate Research, Goettingen, Germany. Electronic address: thaus@dpz.eu.
authors: Tanja
authors: T
authors: Haus
authors: Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, OR, USA.
authors: Betsy
authors: B
authors: Ferguson
authors: Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
authors: Jeffrey
authors: J
authors: Rogers
authors: Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Rijswijk, The Netherlands.
authors: Gaby
authors: G
authors: Doxiadis
authors: Department of Pharmaceutical Sciences (pRED), F. Hoffmann-La Roche Ltd, Basel, Switzerland.
authors: Ulrich
authors: U
authors: Certa
authors: Division of Virology, National Institute for Biological Standards and Control, Potters Bar, UK.
authors: Nicola J
authors: NJ
authors: Rose
authors: EUPRIM-Net, Research Coordination, German Primate Center, Leibniz Institute for Primate Research, Goettingen, Germany.
authors: Robert
authors: R
authors: Teepe
authors: Covance Laboratories GmbH, Muenster, Germany.
authors: Gerhard F
authors: GF
authors: Weinbauer
authors: Gene Bank of Primates and Primate Genetics Laboratory, German Primate Center, Leibniz Institute for Primate Research, Goettingen, Germany.
authors: Christian
authors: C
authors: Roos
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000379:methods* / Q000639:trends; D004195:Disease Models, Animal; D014644:Genetic Variation; D055106:Genome-Wide Association Study / Q000379:methods / Q000639:trends; D023281:Genomics / Q000379:methods* / Q000639:trends; D006801:Humans; D057285:Precision Medicine / Q000379:methods / Q000639:trends; D011323:Primates; D017422:Sequence Analysis, DNA / Q000379:methods / Q000639:trends
keywords: biomedicine; breeding management; genetic variation; genomics; genotyping; primates