title: Bovine lactoferrin and piroxicam as an adjunct treatment for lymphocytic-plasmacytic gingivitis stomatitis in cats.
abstract: Feline lymphocytic-plasmacytic gingivitis/stomatitis (LPGS) or caudal stomatitis is an inflammatory disease that causes painfully erosive lesions and proliferations of the oral mucosa. The disease is difficult to cure and can affect cats at an early age, resulting in lifetime therapy. In this study, a new treatment using a combination of bovine lactoferrin (bLf) oral spray and oral piroxicam was investigated using a randomized double-blinded clinical trial in 13 cats with caudal stomatitis. Oral lesion grading and scoring of clinical signs were conducted during and after the trial to assess treatment outcome. Oral mucosal biopsies were used to evaluate histological changes during and after treatment. Clinical signs were significantly improved in 77% of the cats. In a 4-week study, clinical signs were considerably ameliorated by oral piroxicam during the first 2 weeks. In a 12-week study, the combined bLf oral spray and piroxicam, when compared with piroxicam alone, exhibited an enhanced effect that reduced the severity of the oral lesions (P = 0.059), while also significantly improving clinical signs (P <0.05), quality of life (P <0.05), and weight gain (P <0.05). The remission of oral inflammation was closely correlated with the decreased number of macrophages (OR = 4.719, P < 0.05). There was no detectable influence on liver or kidney function during a 12-week assessment. It was concluded that combining oral bLf spray and piroxicam was safe and might be used to decrease the clinical signs of caudal stomatitis in cats.
authors: Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University, 250 Kuo-Kuang Road, Taichung 40227, Taiwan.
authors: Yi-Ping
authors: YP
authors: Hung
authors: Veterinary Medical Teaching Hospital, College of Veterinary Medicine, National Chung Hsing University, 250 Kuo-Kuang Road, Taichung 40227, Taiwan.
authors: Yi-Ping
authors: YP
authors: Yang
authors: Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University, 250 Kuo-Kuang Road, Taichung 40227, Taiwan; Veterinary Medical Teaching Hospital, College of Veterinary Medicine, National Chung Hsing University, 250 Kuo-Kuang Road, Taichung 40227, Taiwan.
authors: Hsien-Chi
authors: HC
authors: Wang
authors: Graduate Institute of Pathobiology, College of Veterinary Medicine, National Chung Hsing University, 250 Kuo-Kuang Road, Taichung 40227, Taiwan.
authors: Jiunn-Wang
authors: JW
authors: Liao
authors: Graduate Institute of Microbiology and Public Health, College of Veterinary Medicine, National Chung Hsing University, 250 Kuo-Kuang Road, Taichung 40227, Taiwan.
authors: Wei-Li
authors: WL
authors: Hsu
authors: Graduate Institute of Microbiology and Public Health, College of Veterinary Medicine, National Chung Hsing University, 250 Kuo-Kuang Road, Taichung 40227, Taiwan.
authors: Chao-Chin
authors: CC
authors: Chang
authors: Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University, 250 Kuo-Kuang Road, Taichung 40227, Taiwan; Veterinary Medical Teaching Hospital, College of Veterinary Medicine, National Chung Hsing University, 250 Kuo-Kuang Road, Taichung 40227, Taiwan. Electronic address: scchang@dragon.nchu.edu.tw.
authors: Shih-Chieh
authors: SC
authors: Chang
mesh_terms: D000284:Administration, Oral; D000336:Aerosols; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D004311:Double-Blind Method; D007781:Lactoferrin / Q000008:administration & dosage / Q000627:therapeutic use*; D010894:Piroxicam / Q000008:administration & dosage / Q000627:therapeutic use*; D013280:Stomatitis / Q000145:classification / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*
chemical_list: D000336:Aerosols; D000890:Anti-Infective Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam; D007781:Lactoferrin
keywords: Feline; Gingivitis; Lactoferrin; Non-steroidal anti-inflammatory drug; Oral spray; Stomatitis