title: Motor-Language Coupling in Huntington's Disease Families.
abstract: Traditionally, Huntington's disease (HD) has been known as a movement disorder, characterized by motor, psychiatric, and cognitive impairments. Recent studies have shown that motor and action-language processes are neurally associated. The cognitive mechanisms underlying this interaction have been investigated through the action compatibility effect (ACE) paradigm, which induces a contextual coupling of ongoing motor actions and verbal processing. The present study is the first to use the ACE paradigm to evaluate action-word processing in HD patients (HDP) and their families. Specifically, we tested three groups: HDP, healthy first-degree relatives (HDR), and non-relative healthy controls. The results showed that ACE was abolished in HDP as well as HDR, but not in controls. Furthermore, we found that the processing deficits were primarily linguistic, given that they did not correlate executive function measurements. Our overall results underscore the role of cortico-basal ganglia circuits in action-word processing and indicate that the ACE task is a sensitive and robust early biomarker of HD and familial vulnerability.
authors: Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO), Favaloro University , Buenos Aires , Argentina ; National Scientific and Technical Research Council (CONICET) , Buenos Aires , Argentina ; UDP-INECO Foundation Core on Neuroscience (UIFCoN), Diego Portales University , Santiago , Chile.
authors: Lucila
authors: L
authors: Kargieman
authors: Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO), Favaloro University , Buenos Aires , Argentina ; National Scientific and Technical Research Council (CONICET) , Buenos Aires , Argentina ; Universidad Autónoma del Caribe , Barranquilla , Colombia.
authors: Eduar
authors: E
authors: Herrera
authors: Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO), Favaloro University , Buenos Aires , Argentina ; National Scientific and Technical Research Council (CONICET) , Buenos Aires , Argentina ; UDP-INECO Foundation Core on Neuroscience (UIFCoN), Diego Portales University , Santiago , Chile.
authors: Sandra
authors: S
authors: Baez
authors: Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO), Favaloro University , Buenos Aires , Argentina ; National Scientific and Technical Research Council (CONICET) , Buenos Aires , Argentina ; UDP-INECO Foundation Core on Neuroscience (UIFCoN), Diego Portales University , Santiago , Chile ; School of Languages, National University of Córdoba (UNC) , Córdoba , Argentina.
authors: Adolfo M
authors: AM
authors: García
authors: Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO), Favaloro University , Buenos Aires , Argentina.
authors: Martin
authors: M
authors: Dottori
authors: Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO), Favaloro University , Buenos Aires , Argentina.
authors: Carlos
authors: C
authors: Gelormini
authors: Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO), Favaloro University , Buenos Aires , Argentina ; National Scientific and Technical Research Council (CONICET) , Buenos Aires , Argentina ; Australian Research Council (ARC) Centre of Excellence in Cognition and its Disorders , Sydney, NSW , Australia.
authors: Facundo
authors: F
authors: Manes
authors: Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO), Favaloro University , Buenos Aires , Argentina ; National Scientific and Technical Research Council (CONICET) , Buenos Aires , Argentina.
authors: Oscar
authors: O
authors: Gershanik
authors: Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO), Favaloro University , Buenos Aires , Argentina ; National Scientific and Technical Research Council (CONICET) , Buenos Aires , Argentina ; UDP-INECO Foundation Core on Neuroscience (UIFCoN), Diego Portales University , Santiago , Chile ; Universidad Autónoma del Caribe , Barranquilla , Colombia.
authors: Agustín
authors: A
authors: Ibáñez
keywords: ACE; Huntington’s disease; KDT; action–language; familial vulnerability; motor–language coupling