title: Synthesis of 3,3-disubstituted indoline-2-thiones catalysed by an N-heterocyclic carbene.
abstract: A catalytic method has been developed for construction of indoline-2-thiones containing an all-carbon quaternary centre at the C-3 position. Successive treatment of α,β-unsaturated aldehydes bearing an isothiocyanato moiety with an in situ generated N-heterocyclic carbene and an appropriate heteroatomic nucleophile provided the 3,3-disubstituted indoline derivatives in moderate to good yields.
authors: Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan. takemoto@pharm.kyoto-u.ac.jp.
authors: Hideo
authors: H
authors: Ikota
authors: Takayuki
authors: T
authors: Ishida
authors: Chihiro
authors: C
authors: Tsukano
authors: Yoshiji
authors: Y
authors: Takemoto
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D007211:Indoles / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D013871:Thiones / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D007211:Indoles; D013871:Thiones; C030011:carbene; D008697:Methane