title: Pyochelin potentiates the inhibitory activity of gallium on Pseudomonas aeruginosa.
abstract: Gallium (Ga) is an iron mimetic that has successfully been repurposed for antibacterial chemotherapy. To improve the antibacterial potency of Ga on Pseudomonas aeruginosa, the effect of complexation with a variety of siderophores and synthetic chelators was tested. Ga complexed with the pyochelin siderophore (at a 1:2 ratio) was more efficient than Ga(NO3)3 in inhibiting P. aeruginosa growth, and its activity was dependent on increased Ga entrance into the cell through the pyochelin translocon.
authors: Department of Sciences, Roma Tre University, Rome, Italy.
authors: Emanuela
authors: E
authors: Frangipani
authors: Department of Sciences, Roma Tre University, Rome, Italy.
authors: Carlo
authors: C
authors: Bonchi
authors: Department of Sciences, Roma Tre University, Rome, Italy.
authors: Fabrizia
authors: F
authors: Minandri
authors: Department of Biology and Biotechnology C. Darwin, Sapienza University of Rome, Rome, Italy.
authors: Francesco
authors: F
authors: Imperi
authors: Department of Sciences, Roma Tre University, Rome, Italy paolo.visca@uniroma3.it.
authors: Paolo
authors: P
authors: Visca
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001692:Biological Transport / Q000187:drug effects; D002951:Citrates / Q000494:pharmacology; D003676:Deferoxamine / Q000494:pharmacology; D004338:Drug Combinations; D004357:Drug Synergism; D005291:Ferrichrome / Q000494:pharmacology; D005708:Gallium / Q000494:pharmacology*; D009842:Oligopeptides / Q000494:pharmacology; D010636:Phenols / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D017262:Siderophores / Q000494:pharmacology*; D000077559:Sodium Citrate; D013844:Thiazoles / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D002951:Citrates; D004338:Drug Combinations; D009842:Oligopeptides; D010636:Phenols; D017262:Siderophores; D013844:Thiazoles; D005291:Ferrichrome; D000077559:Sodium Citrate; C025316:pyochelin; C042453:pyoverdin; D005708:Gallium; D003676:Deferoxamine