title: [Clinical assessment of CD4/8 ratio of bone marrow lymphocytes in acquired pure red cell aplasia].
abstract: We have reviewed 6 patients with acquired PRCA and investigated CD4/8 ratio in the bone marrow lymphocytes prior to treatment with cyclosporin A (CsA). CsA, as a remission induction therapy, produced CR in 3/6 patients, and PR+NR in 3/6 patients. CD4/8 ratio in CR group was high compared to PR+NR group. Moreover, the number of reticulocyte and hemoglobin concentration in CR group was high in comparison with PR+NR group. In acquired PRCA, CD4/8 ratio in the bone marrow lymphocytes may correlate with the disease status and the outcome of CsA treatment.
authors: Department of Hematology and Oncology, Kumamoto City Hospital.
authors: Takahiro
authors: T
authors: Tsuji
authors: Taichi
authors: T
authors: Hirano
authors: Hiroshi
authors: H
authors: Yamasaki
authors: Hiroyuki
authors: H
authors: Tsuda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001853:Bone Marrow / Q000276:immunology*; D016516:CD4-CD8 Ratio; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012010:Red-Cell Aplasia, Pure / Q000175:diagnosis / Q000276:immunology*; D016896:Treatment Outcome