title: Early suppressive antiretroviral therapy in HIV infection is associated with measurable changes in the corpus callosum.
abstract: The purpose of this study was to examine the impact of early suppressive antiretroviral therapy (ART) on brain structure and neurocognitive outcomes. We conducted an observational study of subjects within 1 year of HIV infection. Ten ART-naïve and 10 ART-suppressed individuals were matched for age and infection duration and age-matched to 10 HIV-seronegative controls. Quantitative brain imaging and neurocognitive data were analyzed. Subjects on suppressive ART had diminished corpus callosum structural integrity on macromolecular and microstructural imaging, higher cerebrospinal fluid percent, higher depression scores, and lower functional performance. Early suppressive ART may alter the trajectory of neurological progression of HIV infection, particularly in the corpus callosum.
authors: Department of Internal Medicine, Feinberg School of Medicine, Northwestern University, 251 East Huron Street, Galter Pavilion Suite 3-150, Chicago, IL, 60611, USA.
authors: Sean G
authors: SG
authors: Kelly
authors: Babafemi O
authors: BO
authors: Taiwo
authors: Ying
authors: Y
authors: Wu
authors: Ramona
authors: R
authors: Bhatia
authors: Casey S
authors: CS
authors: Kettering
authors: Yi
authors: Y
authors: Gao
authors: Suyang
authors: S
authors: Li
authors: Ryan
authors: R
authors: Hutten
authors: Ann B
authors: AB
authors: Ragin
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D003337:Corpus Callosum / Q000187:drug effects* / Q000473:pathology*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000473:pathology*; D006801:Humans; D008297:Male; D059906:Neuroimaging
chemical_list: D044966:Anti-Retroviral Agents