title: Safety evaluation of zeaxanthin concentrate (OmniXan™): acute, subchronic toxicity and mutagenicity studies.
abstract: The available evidence suggests a beneficial effect of zeaxanthin against the progression of age-related macular degeneration (AMD). The objective of the present study was to investigate potential adverse effects of OmniXan™, a RR-zeaxanthin (65%) enriched product obtained from paprika (Capsicum annum fruits) in subchronic toxicity and mutagenicity studies. The oral LD50 of OmniXan(TM) in rats was greater than 2000 mg/kgbody weight (bw)/day. For the subchronic toxicity study, Wistar rats (10/sex/group) were gavaged daily with zeaxanthin concentrate at doses of 0, 4, 40 and 400 mg/kg bw/day for 90-days. No treatment related clinical signs and mortalities observed. Similarly, no treatment related toxicologically significant changes in body weight, feed consumption; ophthalmoscopic examination, neurological examination, hematology, urine analysis and organ weights were observed. Statistically significant changes observed in some clinical chemistry parameters were considered toxicologically and biologically insignificant and nonadverse. Macroscopic and microscopic examinations did not reveal treatment-related abnormalities. The results of mutagenicity testing using Salmonella typhimurium did not reveal any genotoxicity. The no observed-adverse-effect level (NOAEL) for zeaxanthin concentrate (OmniXan(TM)) was determined as 400 mg/kg bw/day, the highest dose tested. The findings of this subchronic toxicity and mutagenicity studies support safety of zeaxanthin concentrate.
authors: BIONEEDS, Devarahosahally, NH-4, Sompura Hobli, Nelamangala Taluk, Bangalore Rural District 562111, Karnataka, India.
authors: K B
authors: KB
authors: Ravi
authors: BIONEEDS, Devarahosahally, NH-4, Sompura Hobli, Nelamangala Taluk, Bangalore Rural District 562111, Karnataka, India.
authors: K R
authors: KR
authors: Raghunatha Reddy
authors: OmniActive Health Technologies Ltd., A 131, Road No.1, Wagle Industrial Estate, Thane (West) 400607, Maharastra, India.
authors: J
authors: J
authors: Shankaranarayanan
authors: OmniActive Health Technologies Ltd., A 131, Road No.1, Wagle Industrial Estate, Thane (West) 400607, Maharastra, India.
authors: Jayant V
authors: JV
authors: Deshpande
authors: OmniActive Health Technologies Inc., Morristown, NJ 07960, USA.
authors: Vijaya
authors: V
authors: Juturu
authors: Soni and Associates Inc., 973, 37th Place, Vero Beach, FL 32960, USA. Electronic address: sonim@bellsouth.net.
authors: Madhu G
authors: MG
authors: Soni
mesh_terms: D000818:Animals; D002212:Capsicum / Q000737:chemistry; D004249:DNA Damage / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D005638:Fruit / Q000737:chemistry; D007928:Lethal Dose 50; D008297:Male; D009152:Mutagenicity Tests; D019055:No-Observed-Adverse-Effect Level; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D012486:Salmonella typhimurium / Q000187:drug effects; D023382:Toxicity Tests, Acute; D036401:Toxicity Tests, Chronic; D065146:Zeaxanthins / Q000633:toxicity*
chemical_list: D010936:Plant Extracts; D065146:Zeaxanthins
keywords: Food ingredient; Safety; Toxicity; Zeaxanthin