title: Associations between thyroid hormones and serum metabolite profiles in an euthyroid population.
abstract: The aim was to characterise associations between circulating thyroid hormones-free thyroxine (FT4) and thyrotropin (TSH)-and the metabolite profiles in serum samples from participants of the German population-based KORA F4 study. Analyses were based on the metabolite profile of 1463 euthyroid subjects. In serum samples, obtained after overnight fasting (≥8), 151 different metabolites were quantified in a targeted approach including amino acids, acylcarnitines (ACs), and phosphatidylcholines (PCs). Associations between metabolites and thyroid hormone concentrations were analysed using adjusted linear regression models. To draw conclusions on thyroid hormone related pathways, intra-class metabolite ratios were additionally explored. We discovered 154 significant associations (Bonferronip< 1.75 × 10-04) between FT4 and various metabolites and metabolite ratios belonging to AC and PC groups. Significant associations with TSH were lacking. High FT4 levels were associated with increased concentrations of many ACs and various sums of ACs of different chain length, and the ratio of C2 by C0. The inverse associations observed between FT4 and many serum PCs reflected the general decrease in PC concentrations. Similar results were found in subgroup analyses, e.g., in weight-stable subjects or in obese subjects. Further, results were independent of different parameters for liver or kidney function, or inflammation, which supports the notion of an independent FT4 effect. In fasting euthyroid adults, higher serum FT4 levels are associated with increased serum AC concentrations and an increased ratio of C2 by C0 which is indicative of an overall enhanced fatty acyl mitochondrial transport and β-oxidation of fatty acids.
authors: Institute of Epidemiology I, Helmholtz Zentrum München, German Research Centre for Environmental Health (HMGU), Ingolstädter Landstraße 1, 85746 Neuherberg, Germany.
authors: Carolin
authors: C
authors: Jourdan
authors: Institute of Epidemiology I, Helmholtz Zentrum München, German Research Centre for Environmental Health (HMGU), Ingolstädter Landstraße 1, 85746 Neuherberg, Germany.
authors: Jakob
authors: J
authors: Linseisen
authors: Institute of Epidemiology I, Helmholtz Zentrum München, German Research Centre for Environmental Health (HMGU), Ingolstädter Landstraße 1, 85746 Neuherberg, Germany.|Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg, Germany.
authors: Christa
authors: C
authors: Meisinger
authors: Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany.
authors: Ann-Kristin
authors: AK
authors: Petersen
authors: Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany.
authors: Christian
authors: C
authors: Gieger
authors: Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany.
authors: Rajesh
authors: R
authors: Rawal
authors: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany.|Hannover Unified Biobank, Hannover Medical School, Hannover, Germany.
authors: Thomas
authors: T
authors: Illig
authors: Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg, Germany.
authors: Margit
authors: M
authors: Heier
authors: Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg, Germany.|Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany.
authors: Annette
authors: A
authors: Peters
authors: Institute of Clinical Chemistry and Laboratory Medicine, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany.
authors: Henri
authors: H
authors: Wallaschofski
authors: Institute of Clinical Chemistry and Laboratory Medicine, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany.
authors: Matthias
authors: M
authors: Nauck
authors: Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, Neuherberg, Germany.
authors: Gabi
authors: G
authors: Kastenmüller
authors: Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, Neuherberg, Germany.|Department of Physiology and Biophysics, Weill Cornell Medical College, Education City, Doha, Qatar.
authors: Karsten
authors: K
authors: Suhre
authors: Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum München, Neuherberg, Germany.
authors: Cornelia
authors: C
authors: Prehn
authors: Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum München, Neuherberg, Germany.|Institute of Experimental Genetics, Life and Food Science Center Weihenstephan, Technische Universität München, Freising-Weihenstephan, Germany.
authors: Jerzy
authors: J
authors: Adamski
authors: Department of Internal Medicine II-Cardiology, University of Ulm, Medical Center, Ulm, Germany.
authors: Wolfgang
authors: W
authors: Koenig
authors: Institute for Clinical Diabetology, German Diabetes Center, Düsseldorf, Germany.
authors: Michael
authors: M
authors: Roden
authors: Institute of Epidemiology I, Helmholtz Zentrum München, German Research Centre for Environmental Health (HMGU), Ingolstädter Landstraße 1, 85746 Neuherberg, Germany.|Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität München, Neuherberg, Germany.|Klinikum Großhadern, Munich, Germany.
authors: H-Erich
authors: HE
authors: Wichmann
authors: Institute for Community Medicine, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany.
authors: Henry
authors: H
authors: Völzke
keywords: Epidemiology; Free thyroxine; Serum metabolites; Targeted metabolomics; Thyroid hormones; Thyrotropin