title: Evaluation of final height prediction and selected parameters in Polish patients with severe and partial growth hormone deficiency.
abstract: OBJECTIVE
  The main goal of growth hormone therapy is to reach the height in the population ranges. The aim of the study was the comparison of selected methods for predicting final height in Polish patients with severe (sGHD) and partial (pGHD) growth hormone deficiency.
  
  
  METHODS
  149 children with growth hormone deficiency treated with rhGH in the Department of Pediatrics, Endocrinology, Diabetology, Metabolic Diseases and Cardiology Developmental Age, PUM, in Szczecin, in 2000-2010 have been evaluated. Patient were divided into two groups: sGHD and pGHD. Two methods of final height prediction have been used: Roche-Weiner-Thissen (RWT) and target height (TH), results were compared to the final height (FH). 117 children finished therapy in the analysed period and reached final height.
  
  
  RESULTS
  The mean FH was similar in both groups. There was no significant difference between the accuracy of prediction methods of TH and RWT between groups of pGHD v. sGHD. Further analysis revealed, that in the group of boys with sGHD the prediction error of RWT was significantly lower than of the TH method (p < 0.05).
  
  
  CONCLUSIONS
  It seems that in the group of boys with sGHD RWT is a more accurate method than TH.
authors: Agnieszka
authors: A
authors: Biczysko-Mokosa
authors: Elzbieta
authors: E
authors: Petriczko
authors: Anita
authors: A
authors: Horodnicka-Józwa
authors: Grazyna
authors: G
authors: Dawid
authors: Andrzej
authors: A
authors: Kedzia
authors: Andrzej
authors: A
authors: Lewiński
authors: Mieczysław
authors: M
authors: Walczak
mesh_terms: D000293:Adolescent; D001827:Body Height; D002648:Child; D004393:Dwarfism, Pituitary / Q000188:drug therapy* / Q000503:physiopathology*; D005260:Female; D020249:Hormone Replacement Therapy; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011044:Poland; D011379:Prognosis; D011994:Recombinant Proteins / Q000627:therapeutic use; D012720:Severity of Illness Index
chemical_list: D011994:Recombinant Proteins; D019382:Human Growth Hormone