title: Amyloid precursor protein and neural development.
abstract: Interest in the amyloid precursor protein (APP) has increased in recent years due to its involvement in Alzheimer's disease. Since its molecular cloning, significant genetic and biochemical work has focused on the role of APP in the pathogenesis of this disease. Thus far, however, these studies have failed to deliver successful therapies. This suggests that understanding the basic biology of APP and its physiological role during development might be a crucial missing link for a better comprehension of Alzheimer's disease. Here, we present an overview of some of the key studies performed in various model organisms that have revealed roles for APP at different stages of neuronal development.
authors: VIB Center for the Biology of Disease, VIB, 3000 Leuven, Belgium Center for Human Genetics, University of Leuven School of Medicine, 3000 Leuven, Belgium Doctoral Program in Molecular and Developmental Genetics, University of Leuven Group Biomedicine, 3000 Leuven, Belgium.
authors: Maya
authors: M
authors: Nicolas
authors: VIB Center for the Biology of Disease, VIB, 3000 Leuven, Belgium Center for Human Genetics, University of Leuven School of Medicine, 3000 Leuven, Belgium Doctoral Program in Molecular and Developmental Genetics, University of Leuven Group Biomedicine, 3000 Leuven, Belgium bh@kuleuven.be.
authors: Bassem A
authors: BA
authors: Hassan
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics* / Q000378:metabolism*; D000818:Animals; D017173:Caenorhabditis elegans; D004331:Drosophila melanogaster; D006801:Humans; D051379:Mice; D008959:Models, Neurological; D009024:Morphogenesis / Q000502:physiology*; D009420:Nervous System / Q000254:growth & development*; D016501:Neurites / Q000502:physiology; D055495:Neurogenesis / Q000235:genetics*; D017434:Protein Structure, Tertiary; D013045:Species Specificity; D013569:Synapses / Q000502:physiology*; D015027:Zebrafish
chemical_list: D016564:Amyloid beta-Protein Precursor
keywords: Amyloid precursor protein; Axonal outgrowth; Neural development; Synapse formation