title: Synthesis and effects of new caffeic acid derivatives on nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophages.
abstract: In this study, 20 new derivatives of caffeic acid esters were synthesized and their inhibitory activities against the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophages were determined. Compounds 3l, 3r, 3s and 3t were found to decrease nitrite levels in a dose-dependent manner in LPS-induced cells and showed potent inhibitory activities against the NO production in RAW264.7 macrophages with IC50 values of 7.4, 5.9, 3.3 and 2.2 μM, respectively. They could be selected as compromising compounds for the later pharmacological study.
authors: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology Shanghai 200237, China.
authors: Jie
authors: J
authors: Zhang
authors: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology Shanghai 200237, China.
authors: Liu-Xin
authors: LX
authors: Xu
authors: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology Shanghai 200237, China.
authors: Xu-Sheng
authors: XS
authors: Xu
authors: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology Shanghai 200237, China.
authors: Bo-Wei
authors: BW
authors: Li
authors: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology Shanghai 200237, China.
authors: Rui
authors: R
authors: Wang
authors: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology Shanghai 200237, China.
authors: Jian-Jun
authors: JJ
authors: Fu
keywords: Caffeic acid; anti-inflammatory; condensation; nitric oxide; structure modification