title: Complementary molecular imaging technologies: High resolution SPECT, PET and MRI.
abstract: Molecular imaging has emerged as a powerful approach for studying drug interactions with cellular targets noninvasively in animal models and humans. Most large pharmaceutical companies are now building capacity for molecular imaging or seeking partnerships with research facilities. Therefore, it is timely to review the features and capabilities of the key technologies - single photon emission computed tomography (SPECT), positron emission tomography (PET) and magnetic resonance imaging (MRI). Owing to the differences in the information they convey and the time scales on which they are able to measure the kinetics of labelled drugs, they form a highly complementary set of technologies.:
authors: School of Medical Radiation Sciences, Faculty of Health Sciences and Ramaciotti Imaging Centre, Brain and Mind Research Institute, University of Sydney, P.O. Box 170, Lidcombe, Sydney, NSW 1825, Australia. Electronic address:smeikle@fhs.usyd.edu.au.
authors: Steven R
authors: SR
authors: Meikle
authors: Department of Nuclear Medicine, Image Sciences Institute and Department of Pharmacology and Anatomy, Rudolf Magnus Institute, University Medical Centre Utrecht, Universiteitsweg 100, STR5.203, 3584 CG Utrecht, The Netherlands.
authors: Freek J
authors: FJ
authors: Beekman
authors: Centre for Magnetic Resonance, University of Queensland, Brisbane, Qld. 4072, Australia.
authors: Stephen E
authors: SE
authors: Rose