title: Evaluation of mean platelet volume in patients with type 2 diabetes mellitus and blood glucose regulation: a marker for atherosclerosis?
abstract: OBJECTIVE
  Platelets have an important role in atherosclerosis and arterial thrombosis. Cardiovascular complication prevalence of type 2 diabetes mellitus (type 2 DM) may be associated with glycosylated hemoglobin (HbA1c) and mean platelet volume (MPV). The aim of the study was to investigate if platelets were activated in diabetes and its associated vascular complications by measuring the MPV in the diabetics compared to the non-diabetics, and to determine the correlation of MPV with fasting serum glucose (FSG), HbA1c and duration of diabetes in the diabetic patients, respectively.
  
  
  METHODS
  The study carried out in 65 patients with type 2 DM and 40 non-diabetic subjects. In addition to non-diabetic patients, all diabetic patients were divided into two groups according to their HbA1c levels: group A consisted of patients with HbA1c levels ≤7% and group B consisted of patients with HbA1c levels >7%.
  
  
  RESULTS
  MPV was significantly higher in Group B as compared to both non-diabetics and Group A. MPV had a high positive correlation with HbA1c and FSG, as with diabetes duration. It is found that MPV was increased in type 2 DM.
  
  
  CONCLUSIONS
  Our findings suggested an association between MPV and HbA1c. Therefore, MPV would be a beneficial prognostic marker of cardio-vascular complications in patients with type 2 DM.
authors: Department of Biochemistry, Kadirli State Hospital Osmaniye, Turkey.
authors: Kemal Turker
authors: KT
authors: Ulutas
authors: Department of Medical Physiology, Medical Faculty, Mustafa Kemal University Hatay, Turkey.
authors: Recep
authors: R
authors: Dokuyucu
authors: Department of Medical Physiology, Medical Faculty, Mustafa Kemal University Hatay, Turkey.
authors: Fatih
authors: F
authors: Sefil
authors: Department of Family Medicine, Medical Faculty, Mustafa Kemal University Hatay, Turkey.
authors: Erhan
authors: E
authors: Yengil
authors: Department of Medical Oncology, Medical Faculty, Mustafa Kemal University Hatay, Turkey.
authors: Ahmet Taner
authors: AT
authors: Sumbul
authors: Department of Internal Medicine, Medical Faculty, Mustafa Kemal University Hatay, Turkey.
authors: Hatice
authors: H
authors: Rizaoglu
authors: Department of Endocrinology and Metabolism, Mustafa Kemal University Hatay, Turkey.
authors: Ihsan
authors: I
authors: Ustun
authors: Department of Medical Microbiology, Medical Faculty, Mustafa Kemal University Hatay, Turkey.
authors: Erkan
authors: E
authors: Yula
authors: Department of Endocrinology and Metabolism, Medical Faculty, Harran University Sanliurfa, Turkey.
authors: Tevfik
authors: T
authors: Sabuncu
authors: Department of Endocrinology and Metabolism, Mustafa Kemal University Hatay, Turkey.
authors: Cumali
authors: C
authors: Gokce
keywords: MPV; atherosclerosis; diabetes duration; glucose regulation