title: Cytotoxic triterpenoids from Saussurea phyllocephala.
abstract: Three new triterpenoids, 11α-hydroxy-lup-20(29)-ene-3β-palmitate (1), 28-hydroxy-20-oxo-30-norlupane-3β-palmitate (2), and 1β,11α,28-tyrihydroxy oleana-9(11),12-dien-3β-palmitate (3), together with three known compounds were isolated from the 95 % EtOH extract of Saussurea phyllocephala. The structures of the new compounds were elucidated on the basis of 1D and 2D NMR (COSY, HMQC, HMBC and NOESY) analyses. All the triterpenoids were in vitro evaluated for their cytotoxic activities. Compound 1-3 exhibited the significant cytotoxic activities with low IC50 values (IC50 < 4.0 μM) against six tumor cell lines (MCF-7, HeLa, HepG2, SGC-7901, NCI-H460 and BGC-823).
authors: College of Biological Resources and Environment Science, Qujing Normal University, Sanjiang Avenue, Unicorn District, Qujing, 655011, Yunnan Province, China, hujiang@ustc.edu.
authors: Jiang
authors: J
authors: Hu
authors: Yan
authors: Y
authors: Song
authors: Benshou
authors: B
authors: Yang
authors: Xiang
authors: X
authors: Zuo
authors: Xiao
authors: X
authors: Mao
authors: Xiaodong
authors: X
authors: Shi
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D030441:Saussurea / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D014315:Triterpenes