title: Effects of nonsteroidal anti-inflammatory meloxicam on stomach, kidney, and liver of rats.
abstract: Nonsteroidal anti-inflammatory (NSAI) drugs are the most commonly used group of drugs today. Increase in the use of standard NSAI for treating pain and inflammation was restricted by the fact that these drugs were proven to possibly cause gastrointestinal and renal toxicity. Meloxicam is a NSAI that has anti-inflammatory, analgesic, and antipyretic effects. This study aims to investigate the effects of meloxicam on stomach, kidney, and liver of rats under light microscopy level. Based on the light microscopic observations, mononuclear cell infiltration and pseudolobular formation was established in liver samples of animals in the experimental group. Metaplasia in surface and glandular epithelia and atrophy were observed in stomach samples. Glomerular stasis-related hypertrophy and focal interstitial nephritis were found in kidneys. It was concluded in this study that meloxicam might cause hepatotoxicity, nephrotoxicity, and gastric metaplasia in rats at a used dose and duration.
authors: Department of Histology and Embryology, School of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey.
authors: Dilek
authors: D
authors: Burukoglu
authors: Department of Histology and Embryology, School of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey.
authors: Cengiz
authors: C
authors: Baycu
authors: Department of Obstetrics and Gynecology, School of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey.
authors: Fulya
authors: F
authors: Taplamacioglu
authors: Department of Histology and Embryology, School of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey sahine@ogu.edu.tr.
authors: Erhan
authors: E
authors: Sahin
authors: Department of Histology and Embryology, School of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey.
authors: Ezgi
authors: E
authors: Bektur
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis; D051546:Cyclooxygenase 2 / Q000235:genetics / Q000378:metabolism; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D007249:Inflammation / Q000188:drug therapy; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced / Q000175:diagnosis; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D000077239:Meloxicam; D008679:Metaplasia / Q000139:chemically induced; D010146:Pain / Q000188:drug therapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D013270:Stomach / Q000187:drug effects* / Q000473:pathology; D013272:Stomach Diseases / Q000139:chemically induced / Q000175:diagnosis; D013843:Thiazines / Q000494:pharmacology*; D013844:Thiazoles / Q000494:pharmacology*; D018675:Toxicity Tests
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D013843:Thiazines; D013844:Thiazoles; D051546:Cyclooxygenase 2; C489691:Ptgs2 protein, rat; D000077239:Meloxicam
keywords: Nonsteroidal anti-inflammatory (NSAI) drugs; kidney; liver; meloxicam; rats; stomach