title: Investigation of the relationship of some antihypertensive drugs with oxidant/antioxidant parameters and DNA damage on rat uterus tissue.
abstract: BACKGROUND
  In this study, we investigated the effects of treatment with chronic antihypertensive drugs (clonidine, methyldopa, amlodipine, ramipril and rilmenidine) on oxidant-antioxidant parameters and toxic effects on DNA in rat uterus tissue. In addition, uterus tissues were examined histopathologically.
  
  
  METHODS
  A total of 36 albino Wistar rats were divided into the following six groups: 0.075 mg/kg clonidine group; 100 mg/kg methyldopa group; 2 mg/kg amlodipine group; 2.5 mg/kg ramipril group; 0.5 mg/kg rilmenidine group; and the healthy group. Rats underwent chronic drug administration for 30 days and at the end, biochemical and histopathological examinations were performed. All data were subjected to one-way ANOVA test.
  
  
  RESULTS
  We divided these drugs into the following three groups according to their effects on rat uteri: (I) mild negative effects (clonidine), (II) moderate negative effects (rilmenidine, methyldopa) and (III) drugs which had severe negative effects (amlodipine, ramipril).
  
  
  CONCLUSIONS
  These data may help with selection of antihypertensive drugs, in order to determine which drugs have the lowest toxicity in pregnant and non-pregnant (pre-pregnancy) women.
authors: Ministry of Health, Obstetrics and Gynecology Hospital, Igdir, Turkey.
authors: Suleyman
authors: S
authors: Salman
authors: Ministry of Health, Obstetrics and Gynecology Hospital, Igdir, Turkey.
authors: Serkan
authors: S
authors: Kumbasar
authors: Department of Pathology, Ataturk University Medical Faculty, 25240 Erzurum, Turkey.
authors: Nesrin
authors: N
authors: Gursan
authors: Department of Obstetrics and Gynecology, Ataturk University Medical Faculty, 25240 Erzurum, Turkey.
authors: Yakup
authors: Y
authors: Kumtepe
authors: Department of Obstetrics and Gynecology, Ataturk University Medical Faculty, 25240 Erzurum, Turkey.
authors: Bunyamin
authors: B
authors: Borekci
authors: Department of Pharmacology, Ataturk University Medical Faculty, 25240 Erzurum, Turkey.
authors: Beyzagul
authors: B
authors: Polat
authors: Department of Biochemistry, Ataturk University Medical Faculty, 25240 Erzurum, Turkey.
authors: Hamit
authors: H
authors: Hakan Alp
authors: Department of Forensic Medicine, Ataturk University Medical Faculty, 25240 Erzurum, Turkey.
authors: Mustafa
authors: M
authors: Talip Sener
authors: Department of Pharmacology, Ataturk University Medical Faculty, 25240 Erzurum, Turkey.
authors: Halis
authors: H
authors: Suleyman
keywords: Antihypertensive; DNA Damage; Oxidant/Antioxidant Parameters