title: The (G>A) rs11573191 polymorphism of PLA2G5 gene is associated with premature coronary artery disease in the Mexican Mestizo population: the genetics of atherosclerotic disease Mexican study.
abstract: Coronary artery disease (CAD) is a multifactorial disorder that results from an excessive inflammatory response. Secretory phospholipase A2-V (sPLA2-V) encoded by PLA2G5 gene promotes diverse proinflammatory processes. The aim of the present study was to analyze if PLA2G5 gene polymorphisms are associated with premature CAD. Three PLA2G5 polymorphisms (rs11573187, rs2148911, and rs11573191) were analyzed in 707 patients with premature CAD and 749 healthy controls. Haplotypes were constructed after linkage disequilibrium analysis. Under dominant, recessive, and additive models, the rs11573191 polymorphism was associated with increased risk of premature CAD (OR = 1.51, P(dom) = 3.5 × 10(-3); OR = 2.95, P(rec) = 0.023; OR = 1.51, P(add) = 1.2 × 10(-3)). According to the informatics software, this polymorphism had a functional effect modifying the affinity of the sequence by the MZF1 transcription factor. PLA2G5 polymorphisms were in linkage disequilibrium and the CGA haplotype was associated with increased risk of premature CAD (OR = 1.49, P = 0.0023) and with hypertension in these patients (OR = 1.75, P = 0.0072). Our results demonstrate the association of the PLA2G5 rs11573191 polymorphism with premature CAD. In our study, it was possible to distinguish one haplotype associated with increased risk of premature CAD and hypertension.
authors: Departments of Molecular Biology, Endocrinology, and Immunology, National Institute of Cardiology Ignacio Chávez, 14080 Mexico City, DF, Mexico.
authors: Gilberto
authors: G
authors: Vargas-Alarcón
authors: Department of Endocrinology, National Institute of Cardiology Ignacio Chávez, Juan Badiano 1, Sección XVI, Tlalpan, 14080 Mexico City, DF, Mexico.
authors: Carlos
authors: 0000-0002-0546-9794
authors: C
authors: Posadas-Romero
authors: Cardiovascular Genomics Laboratory, National Institute of Genomic Medicine, 14610 Mexico City, DF, Mexico.
authors: Teresa
authors: T
authors: Villarreal-Molina
authors: Departments of Molecular Biology, Endocrinology, and Immunology, National Institute of Cardiology Ignacio Chávez, 14080 Mexico City, DF, Mexico.
authors: Edith
authors: E
authors: Alvarez-León
authors: Departments of Molecular Biology, Endocrinology, and Immunology, National Institute of Cardiology Ignacio Chávez, 14080 Mexico City, DF, Mexico.
authors: Javier
authors: J
authors: Angeles-Martinez
authors: Department of Immunology, National Institute of Cardiology Ignacio Chávez, Juan Badiano 1, Sección XVI, Tlalpan, 14080 Mexico City, DF, Mexico.
authors: María Elena
authors: ME
authors: Soto
authors: Departments of Molecular Biology, Endocrinology, and Immunology, National Institute of Cardiology Ignacio Chávez, 14080 Mexico City, DF, Mexico.
authors: Irma
authors: I
authors: Monroy-Muñoz
authors: Department of Endocrinology, National Institute of Cardiology Ignacio Chávez, Juan Badiano 1, Sección XVI, Tlalpan, 14080 Mexico City, DF, Mexico.
authors: Juan Gabriel
authors: JG
authors: Juárez
authors: Departments of Molecular Biology, Endocrinology, and Immunology, National Institute of Cardiology Ignacio Chávez, 14080 Mexico City, DF, Mexico.
authors: Carlos Jerges
authors: CJ
authors: Sánchez-Ramírez
authors: Laboratory of Genomic Medicine, Research Unit, Juárez de México Hospital, 07760 Mexico City, DF, Mexico.
authors: Julian
authors: J
authors: Ramirez-Bello
authors: Departments of Molecular Biology, Endocrinology, and Immunology, National Institute of Cardiology Ignacio Chávez, 14080 Mexico City, DF, Mexico.
authors: Silvestre
authors: S
authors: Ramírez-Fuentes
authors: Departments of Molecular Biology, Endocrinology, and Immunology, National Institute of Cardiology Ignacio Chávez, 14080 Mexico City, DF, Mexico.
authors: José Manuel
authors: JM
authors: Fragoso
authors: Departments of Molecular Biology, Endocrinology, and Immunology, National Institute of Cardiology Ignacio Chávez, 14080 Mexico City, DF, Mexico.
authors: José Manuel
authors: 0000-0002-3802-0897
authors: JM
authors: Rodríguez-Pérez
mesh_terms: D000328:Adult; D003324:Coronary Artery Disease / Q000235:genetics* / Q000473:pathology; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D054505:Group V Phospholipases A2 / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000473:pathology; D008297:Male; D008800:Mexico; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D054505:Group V Phospholipases A2; C516299:PLA2G5 protein, human