title: Fiber-optic raster scanning two-photon endomicroscope using a tubular piezoelectric actuator.
abstract: A nonresonant, fiber-optic raster scanning endomicroscope was developed using a quarter-tubular piezoelectric (PZT) actuator. A fiber lever mechanism was utilized to enhance the small actuation range of the tubular PZT actuator and to increase its field-of-view. Finite element method simulation of the endoscopic probe was conducted for various conditions to maximize its scanning range. After fabricating the probe using a double clad fiber, we obtained two-photon fluorescence images using raster beam scanning of the fiber. The outer diameter of the probe was 3.5 mm and its rigid distal length was 30 mm including a high numerical aperture gradient index lens. These features are sufficient for input into the instrumental channel of a commercial colonoscope or gastroscope to obtain high resolution images in vivo.
authors: Korea Advanced Institute of Science and Technology, Nano Opto-Mechatronics Laboratory, Department of Mechanical Engineering, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Republic of Korea.
authors: Dukho
authors: D
authors: Do
authors: Hanyang University, Biomedial Optics and Photomedicine Laboratory, Department of Biomedical Engineering, 222 Wangsimni-ro, Seongdong-gu, Seoul 133-791, Republic of Korea.
authors: Hongki
authors: H
authors: Yoo
authors: Korea Advanced Institute of Science and Technology, Nano Opto-Mechatronics Laboratory, Department of Mechanical Engineering, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Republic of Korea.
authors: Dae-Gab
authors: DG
authors: Gweon
mesh_terms: D000818:Animals; D003113:Colonoscopy / Q000295:instrumentation / Q000379:methods; D003198:Computer Simulation; D004581:Electronics; D004724:Endoscopy / Q000295:instrumentation / Q000379:methods*; D004867:Equipment Design; D005336:Fiber Optic Technology; D020342:Finite Element Analysis; D005767:Gastrointestinal Diseases / Q000175:diagnosis; D007091:Image Processing, Computer-Assisted; D007668:Kidney / Q000473:pathology; D051379:Mice; D008853:Microscopy / Q000379:methods*; D017785:Photons; D012031:Refractometry