title: Four new sesquiterpenoids from fruiting bodies of the fungus Inonotus rickii.
abstract: Three new bisabolane sesquiterpenoids, inonotic acid A (1), 3-O-formyl inonotic acid A (2), inonotic acid B (3), and one new drimane sesquiterpenoid 3α,6β-dihydroxycinnamolide (4), were isolated from the fruiting bodies of mushroom Inonotus rickii. Their structures were elucidated by means of extensive spectroscopic methods. Compound 4 had moderate inhibitory activity on human colon cancer SW480 (IC50 = 20.4 μmol).
authors: a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
authors: He-Ping
authors: HP
authors: Chen
authors: Wen-Bin
authors: WB
authors: Dong
authors: Tao
authors: T
authors: Feng
authors: Xia
authors: X
authors: Yin
authors: Zheng-Hui
authors: ZH
authors: Li
authors: Ze-Jun
authors: ZJ
authors: Dong
authors: Yan
authors: Y
authors: Li
authors: Ji-Kai
authors: JK
authors: Liu
mesh_terms: D000363:Agaricales / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002681:China; D004354:Drug Screening Assays, Antitumor; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C000591868:3alpha,6beta-dihydroxycinnamolide; D000970:Antineoplastic Agents; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C437376:drimane; C000591865:inonotic acid A; C000591867:inonotic acid B
keywords: Inonotus rickii; cytotoxicity; sesquiterpenoid