title: Onset of virus systemic infection in plants is determined by speed of cell-to-cell movement and number of primary infection foci.
abstract: The cornerstone of today's plant virology consists of deciphering the molecular and mechanistic basis of host-pathogen interactions. Among these interactions, the onset of systemic infection is a fundamental variable in studying both within- and between-host infection dynamics, with implications in epidemiology. Here, we developed a mechanistic model using probabilistic and spatio-temporal concepts to explain dynamic signatures of virus systemic infection. The model dealt with the inherent characteristic of plant viruses to use two different and sequential stages for their within-host propagation: cell-to-cell movement from the initial infected cell and systemic spread by reaching the vascular system. We identified the speed of cell-to-cell movement and the number of primary infection foci in the inoculated leaf as the key factors governing this dynamic process. Our results allowed us to quantitatively understand the timing of the onset of systemic infection, describing this global process as a consequence of local spread of viral populations. Finally, we considered the significance of our predictions for the evolution of plant RNA viruses.
authors: Institute of Systems and Synthetic Biology, CNRS-Université d'Évry Val d'Essonne-Genopole, Évry 91030, France Instituto de Biología Molecular y Celular de Plantas, CSIC-Universidad Politécnica de Valencia, Valencia 46022, Spain guillermo.rodrigo@issb.genopole.fr.
authors: Guillermo
authors: G
authors: Rodrigo
authors: Instituto de Biología Molecular y Celular de Plantas, CSIC-Universidad Politécnica de Valencia, Valencia 46022, Spain.
authors: Mark P
authors: MP
authors: Zwart
authors: Instituto de Biología Molecular y Celular de Plantas, CSIC-Universidad Politécnica de Valencia, Valencia 46022, Spain The Santa Fe Institute, Santa Fe, NM 87501, USA.
authors: Santiago F
authors: SF
authors: Elena
mesh_terms: D054884:Host-Pathogen Interactions; D008962:Models, Theoretical; D010935:Plant Diseases / Q000821:virology*; D018515:Plant Leaves / Q000821:virology; D010942:Plant Viruses / Q000502:physiology*; D010944:Plants / Q000821:virology*; D013997:Time Factors; D014026:Nicotiana / Q000821:virology*; D014027:Tobacco Mosaic Virus
keywords: local versus global infection; systems biology of virus infection; virus evolution; within-host virus dynamics