title: Current perspectives in stem cell therapy for spinal cord repair in humans: a review of work from the past 10 years.
abstract: Spinal cord injury (SCI) and amyotrophic laterals sclerosis (ALS) are devastating neurological conditions that affect individuals worldwide, significantly reducing quality of life, both for patients and their relatives.
  
  
  OBJECTIVE
  The present review aims to summarize the multiple restorative approaches being developed for spinal cord repair, the use of different stem cell types and the current knowledge regarding stem cell therapy.
  
  
  METHODS
  Review of the literature from the past 10 years of human studies using stem cell transplantation as the main therapy, with or without adjuvant therapies.
  
  
  CONCLUSIONS
  The current review offers an overview of the state of the art regarding spinal cord restoration, and serves as a starting point for future studies.
authors: Departamento de Neurologia, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil.
authors: Eric Domingos
authors: ED
authors: Mariano
authors: Departamento de Neurologia, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil.
authors: Chary Marquez
authors: CM
authors: Batista
authors: Departamento de Neurologia, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil.
authors: Breno José Alencar Pires
authors: BJ
authors: Barbosa
authors: Departamento de Neurologia, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil.
authors: Suely Kazue Nagahashi
authors: SK
authors: Marie
authors: Departamento de Neurologia, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil.
authors: Manoel Jacobsen
authors: MJ
authors: Teixeira
authors: Department of Neurosurgery, Eberhard-Karls University, Tuebingen, Germany.
authors: Matthias
authors: M
authors: Morgalla
authors: Department of Neurosurgery, Eberhard-Karls University, Tuebingen, Germany.
authors: Marcos
authors: M
authors: Tatagiba
authors: Department of Neurosurgery, Eberhard-Karls University, Tuebingen, Germany.
authors: Jun
authors: J
authors: Li
authors: Departamento de Neurologia, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil.
authors: Guilherme
authors: G
authors: Lepski
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000628:therapy*; D006801:Humans; D013119:Spinal Cord Injuries / Q000628:therapy*; D058630:Spinal Cord Regeneration; D033581:Stem Cell Transplantation / Q000639:trends*; D013234:Stem Cells / Q000166:cytology