title: [Chemical constituents of leaves of Psidium guajava].
abstract: To study the chemical constituents of the 95% ethanol extract of Psidium guajava. Compounds were separated by using a combination of various chromatographic methods including silica gel, D101 macroporous resin, ODS, Sephadex LH-20 and preparative HPLC. Their structures were elucidated by physicochemical properties and spectral data Eighteen compounds were isolated and identified as (+) -globulol (1), clovane-2beta, 9alpha-diol (2), 2beta-acetoxyclovan-9alpha-ol (3), (+) -caryolane-1 ,9beta-diol (4), ent-T-muurolol (5), clov-2-ene-9alpha-ol (6), isophytol (7), tamarixetin (8), gossypetin (9), quercetin (10), kaempferol (11), guajaverin (12), avicularin (13), chrysin 6-C-glucoside (14), 3'-O-methyl-3, 4-methylenedioxyellagic acid 4'-O-beta-D-glucopyranoside (15), p-hydroxy-benzoic acid (16), guavinoside A (17) and guavinoside B (18). Compounds 2-9 and 14-16 were isolated from this plant for the first time. The ethanol extract showed 61.3% inhibition against the proliferation of colon cancer cell line SW480.
authors: Meng
authors: M
authors: Shao
authors: Ying
authors: Y
authors: Wang
authors: Yu-Qing
authors: YQ
authors: Jian
authors: Xue-Gang
authors: XG
authors: Sun
authors: Xiao-Jun
authors: XJ
authors: Huang
authors: Xiao-Qi
authors: XQ
authors: Zhang
authors: Wen-Cai
authors: WC
authors: Ye
mesh_terms: D004365:Drugs, Chinese Herbal / Q000737:chemistry; D009930:Organic Chemicals / Q000032:analysis*; D018515:Plant Leaves / Q000737:chemistry*; D031647:Psidium / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal; D009930:Organic Chemicals