title: Detection of Corynebacterium bovis infection in athymic nude mice from a research animal facility in Korea.
abstract: Corynebacterium (C.) bovis infection in nude mice causes hyperkeratosis and weight loss and has been reported worldwide but not in Korea. In 2011, nude mice from an animal facility in Korea were found to have white flakes on their dorsal skin. Histopathological testing revealed that the mice had hyperkeratosis and Gram-positive bacteria were found in the skin. We identified isolated bacteria from the skin lesions as C. bovis using PCR and 16S rRNA sequencing. To the best of our knowledge, this is the first report of C. bovis infection in nude mice from Korea.
authors: Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea.
authors: Tae-Hyoun
authors: TH
authors: Kim
authors: Dong-Su
authors: DS
authors: Kim
authors: Ju-Hee
authors: JH
authors: Han
authors: Seo-Na
authors: SN
authors: Chang
authors: Kyung-Sul
authors: KS
authors: Kim
authors: Seung-Hyeok
authors: SH
authors: Seok
authors: Dong-Jae
authors: DJ
authors: Kim
authors: Jong-Hwan
authors: JH
authors: Park
authors: Jae-Hak
authors: JH
authors: Park
mesh_terms: D000818:Animals; D003352:Corynebacterium / Q000302:isolation & purification*; D003354:Corynebacterium Infections / Q000382:microbiology* / Q000473:pathology; D051379:Mice; D008819:Mice, Nude; D016133:Polymerase Chain Reaction / Q000662:veterinary; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D056910:Republic of Korea; D012376:Rodent Diseases / Q000382:microbiology* / Q000473:pathology; D017192:Skin Diseases, Bacterial / Q000382:microbiology* / Q000473:pathology
chemical_list: D012336:RNA, Ribosomal, 16S
keywords: Corynebacterium bovis; athymic nude mice; hyperkeratosis