title: Haplotype analysis of the XRCC1 gene and laryngeal cancer.
abstract: OBJECTIVE
  Several polymorphisms in DNA repair genes have been extensively studied in association with various human cancers, including laryngeal cancer. The present study aimed to investigate the association between polymorphisms of the XRCC1 gene and laryngeal cancer in a Chinese population.
  
  
  METHODS
  Five polymorphisms of the XRCC1 gene (rs3213403, rs1799778, rs1001581, rs3213282, and rs3810378) were genotyped by TaqMan in 234 patients with larynx cancer and 230 age- and sex-matched controls without cancer.
  
  
  RESULTS
  The rs3213403, rs1799778, and rs3213282 polymorphisms of XRCC1 were associated with larynx cancer. Haplotype analysis indicated that CCA (odds ratio [OR], 5.707; 95% confidence interval [CI], 3.277-9.938; p<0.001), TGG (OR, 4.344; 95% CI, 2.804-6.732; p<0.001), ACA (OR, 1.615; 95% CI, 1.159-2.250; p=0.004), and GCG (OR, 1.702; 95% CI, 1.164-2.489; p=0.005) were associated with an increased risk for larynx cancer, respectively. However, TGA (OR, 0.518; 95% CI, 0.398-0.673; p<0.001) and ACC (OR, 0.314; 95% CI, 0.215-0.457; p<0.001) were associated with a decreased risk for larynx cancer.
  
  
  CONCLUSIONS
  The results indicated that XRCC1 genetic polymorphisms were associated with larynx cancer in a Chinese population.
authors: 1 Department of Otolaryngology-Head and Neck Surgery, Jinling Hospital, Nanjing Clinical Medical College, Second Military Medical University , Nanjing, Jiangsu, People's Republic of China .
authors: Wei
authors: W
authors: Chen
authors: Li
authors: L
authors: Xu
authors: Zhi-Yi
authors: ZY
authors: Wang
authors: Li-Jun
authors: LJ
authors: Xue
authors: Feng-Lei
authors: FL
authors: Xue
authors: Man-Jie
authors: MJ
authors: Jiang
authors: Qiu-Ping
authors: QP
authors: Wang
authors: Hong-Liang
authors: HL
authors: Zheng
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D016022:Case-Control Studies; D002681:China; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D006239:Haplotypes; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020133:Reverse Transcriptase Polymerase Chain Reaction; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human