title: Timing of response differentiation in human motor cortex during a speeded Go/No-Go task.
abstract: We explored the brain's ability to quickly prevent a pre-potent but unwanted motor response. To address this, transcranial magnetic stimulation was delivered over the motor cortex (hand representation) to probe excitability changes immediately after somatosensory cues prompted subjects to either move as fast as possible or withhold movement. Our results showed a difference in motor cortical excitability 90ms post-stimulus contingent on cues to either promote or prevent movement. We suggest that our study design emphasizing response speed coupled with well-defined early probes allowed us to extend upon similar past investigations into the timing of response inhibition.
authors: Department of Kinesiology, University of Waterloo, Waterloo, ON, Canada; Heart and Stroke Foundation Centre for Stroke Recovery, ON, Canada. Electronic address: d.bolton@qub.ac.uk.
authors: David A E
authors: DA
authors: Bolton
authors: Department of Kinesiology, University of Waterloo, Waterloo, ON, Canada; Heart and Stroke Foundation Centre for Stroke Recovery, ON, Canada; Sunnybrook Health Sciences Centre Research Institute, Toronto, ON, Canada.
authors: Michael
authors: M
authors: Vesia
authors: Graduate Department of Rehabilitation Science, University of Toronto, Toronto, ON, Canada; Mobility Research Team, Toronto Rehabilitation Institute, Toronto, ON, Canada.
authors: Bimal
authors: B
authors: Lakhani
authors: Department of Kinesiology, University of Waterloo, Waterloo, ON, Canada; Heart and Stroke Foundation Centre for Stroke Recovery, ON, Canada.
authors: W Richard
authors: WR
authors: Staines
authors: Department of Kinesiology, University of Waterloo, Waterloo, ON, Canada; Heart and Stroke Foundation Centre for Stroke Recovery, ON, Canada; Sunnybrook Health Sciences Centre Research Institute, Toronto, ON, Canada; Graduate Department of Rehabilitation Science, University of Toronto, Toronto, ON, Canada; Mobility Research Team, Toronto Rehabilitation Institute, Toronto, ON, Canada.
authors: William E
authors: WE
authors: McIlroy
mesh_terms: D000328:Adult; D019054:Evoked Potentials, Motor / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D009044:Motor Cortex / Q000502:physiology*; D009068:Movement / Q000502:physiology*; D009433:Neural Inhibition / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology*; D050781:Transcranial Magnetic Stimulation; D055815:Young Adult
keywords: Go/No-Go; Motor cortex; Response inhibition; Speed of processing; Transcranial magnetic stimulation