title: Clinical pharmacology of the anti-IL-17 receptor antibody brodalumab (KHK4827) in Japanese normal healthy volunteers and Japanese subjects with moderate to severe psoriasis: a randomized, dose-escalation, placebo-controlled study.
authors: Kojinkai Sapporo Skin Clinic, H&B plaza building 5F, S3 w2, Chuo-ku, Sapporo Hokkaido, 060-0063, Japan. Electronic address: osamu.nemo@gmail.com.
authors: Nemoto
authors: N
authors: Osamu
authors: Yanagibashi-Clinical Trial Center, Yanagibashi Hospital, Tokyo, Japan. Electronic address: nagashima@y-ctc.com.
authors: Nagashima
authors: N
authors: Hirotaka
authors: Department of Dermatology, Ehime University Graduate School of Medicine, Ehime, Japan. Electronic address: sayama@m.ehime-u.ac.jp.
authors: Sayama
authors: S
authors: Koji
authors: Shinanozaka Clinic, Medical Corporation Shinanokai, Tokyo, Japan. Electronic address: k-takazawa@shinanozaka-clinic.jp.
authors: Takazawa
authors: T
authors: Kenji
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000737:chemistry / Q000494:pharmacology*; D061067:Antibodies, Monoclonal, Humanized; D016207:Cytokines / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy* / Q000276:immunology*; D011788:Quality of Life; D053722:Receptors, Interleukin-17 / Q000276:immunology*; D013997:Time Factors; D055815:Young Adult
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D016207:Cytokines; D053722:Receptors, Interleukin-17; C571216:brodalumab