title: Vitamin D improves cognitive function and modulates Th17/T reg cell balance after hepatectomy in mice.
abstract: It is known that surgery-induced tissue damage activates the peripheral immune system resulting in the release of inflammatory mediators and cognitive impairment in aged mice. Vitamin D has been shown to have immunomodulatory function, but the molecular basis for it has not been well understood. In this study, we mainly investigated the efficacy and mechanism of vitamin D against postoperative cognitive dysfunction (POCD). The treatment of C57BL mice with vitamin D significantly preserves postoperative cognitive function, markedly inhibits surgery-induced interleukin (IL)-17, IL-6, transforming growth factor beta (TGF-β), and retinoic acid-related orphan receptor (RORγt) production, and obviously induces IL-10 and forkhead box p3 (Foxp3) expression. These findings indicate that vitamin D amelioration of POCD is, to a large extent, due to inhibit inflammatory CD4_T cell lineage, T helper 17 (Th17) cells, accompanied with expansion in regulatory T cells (Treg cells), a subset of CD4_T cells that are important in inhibiting inflammation. Our results suggest that Th17 and Treg cell imbalance may play a role in the development of POCD. Vitamin D is useful in the control of inflammatory diseases.
authors: Department of Anesthesiology, The First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Heping, Shenyang, 110001, Liaoning, China.
authors: Ayong
authors: A
authors: Tian
authors: Hong
authors: H
authors: Ma
authors: Xuezhao
authors: X
authors: Cao
authors: Rongwei
authors: R
authors: Zhang
authors: Xiaolong
authors: X
authors: Wang
authors: Binyang
authors: B
authors: Wu
mesh_terms: D000818:Animals; D003071:Cognition / Q000187:drug effects*; D005260:Female; D051858:Forkhead Transcription Factors / Q000096:biosynthesis; D006498:Hepatectomy / Q000009:adverse effects; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D016753:Interleukin-10 / Q000096:biosynthesis; D020381:Interleukin-17 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D008099:Liver / Q000166:cytology; D018655:Lymphocyte Count; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3 / Q000096:biosynthesis; D011183:Postoperative Complications / Q000188:drug therapy*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D058504:Th17 Cells / Q000276:immunology*; D016212:Transforming Growth Factor beta / Q000096:biosynthesis; D014807:Vitamin D / Q000494:pharmacology*
chemical_list: D051858:Forkhead Transcription Factors; C498833:Foxp3 protein, mouse; D020381:Interleukin-17; D015850:Interleukin-6; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D016212:Transforming Growth Factor beta; D016753:Interleukin-10; D014807:Vitamin D