title: Regioselective desymmetrization of diaryltetrahydrofurans via directed ortho-lithiation: an unexpected help from green chemistry.
abstract: An efficient functionalization of diaryltetrahydrofurans via a regioselective THF-directed ortho-lithiation is first described. This reaction can be successfully carried out in cyclopentyl methyl ether as a "greener" alternative to Et2O, with better results in terms of yield and selectivity and, surprisingly, also in protic eutectic mixtures competitively with protonolysis.
authors: Dipartimento di Farmacia-Scienze del Farmaco, Università di Bari "Aldo Moro", Consorzio C.I.N.M.P.I.S., Via E. Orabona 4, Bari, I-70125, Italy. vito.capriati@uniba.it.
authors: Valentina
authors: V
authors: Mallardo
authors: Ruggiero
authors: R
authors: Rizzi
authors: Francesca C
authors: FC
authors: Sassone
authors: Rosmara
authors: R
authors: Mansueto
authors: Filippo M
authors: FM
authors: Perna
authors: Antonio
authors: A
authors: Salomone
authors: Vito
authors: V
authors: Capriati
mesh_terms: D004787:Environmental Pollution / Q000517:prevention & control; D005663:Furans / Q000737:chemistry*; D008094:Lithium / Q000737:chemistry*; D008968:Molecular Conformation; D011522:Protons; D013237:Stereoisomerism
chemical_list: D005663:Furans; D011522:Protons; D008094:Lithium