title: Differences in coronary risk factors, procedural characteristics, mortality and stent thrombosis between two all-comers percutaneous coronary intervention registries from Europe and Japan: a patient-level data analysis of the Bern-Rotterdam and j-Cypher registries.
abstract: OBJECTIVE
  The reported rate of stent thrombosis (ST) after drug-eluting stent (DES) implantation varies among registries. To investigate differences in baseline characteristics and clinical outcome in European and Japanese all-comers registries, we performed a pooled analysis of patient-level data.
  
  
  RESULTS
  The j-Cypher registry (JC) is a multicentre observational study conducted in Japan, including 12,824 patients undergoing SES implantation. From the Bern-Rotterdam registry (BR) enrolled at two academic hospitals in Switzerland and the Netherlands, 3,823 patients with SES were included in the current analysis. Patients in BR were younger, more frequently smokers and presented more frequently with ST-elevation myocardial infarction (MI). Conversely, JC patients more frequently had diabetes and hypertension. At five years, the definite ST rate was significantly lower in JC than BR (JC 1.6% vs. BR 3.3%, p<0.001), while the unadjusted mortality tended to be lower in BR than in JC (BR 13.2% vs. JC 14.4%, log-rank p=0.052). After adjustment, the j-Cypher registry was associated with a significantly lower risk of all-cause mortality (HR 0.56, 95% CI: 0.49-0.64) as well as definite stent thrombosis (HR 0.46, 95% CI: 0.35-0.61).
  
  
  CONCLUSIONS
  The baseline characteristics of the two large registries were different. After statistical adjustment, JC was associated with lower mortality and ST.
authors: Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands.
authors: Yoshinobu
authors: Y
authors: Onuma
authors: Takeshi
authors: T
authors: Kimura
authors: Lorenz
authors: L
authors: Räber
authors: Michael
authors: M
authors: Magro
authors: Chrisafios
authors: C
authors: Girasis
authors: Ron
authors: R
authors: van Domburg
authors: Stephan
authors: S
authors: Windecker
authors: Kazuaki
authors: K
authors: Mitsudo
authors: Patrick W
authors: PW
authors: Serruys
mesh_terms: D054058:Acute Coronary Syndrome / Q000453:epidemiology / Q000628:therapy*; D000367:Age Factors; D000368:Aged; D003328:Coronary Thrombosis / Q000453:epidemiology*; D003920:Diabetes Mellitus / Q000453:epidemiology; D054855:Drug-Eluting Stents; D005260:Female; D006083:Graft Occlusion, Vascular / Q000453:epidemiology*; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D007564:Japan; D008297:Male; D008875:Middle Aged; D009026:Mortality; D009203:Myocardial Infarction / Q000453:epidemiology / Q000628:therapy*; D009426:Netherlands; D062645:Percutaneous Coronary Intervention / Q000706:statistics & numerical data*; D011475:Prosthesis Failure; D012042:Registries; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology; D013557:Switzerland