title: Novel biomarkers of abdominal aortic aneurysm disease: identifying gaps and dispelling misperceptions.
abstract: Abdominal aortic aneurysm (AAA) is a prevalent and potentially life-threatening disease. Early detection by screening programs and subsequent surveillance has been shown to be effective at reducing the risk of mortality due to aneurysm rupture. The aim of this review is to summarize the developments in the literature concerning the latest biomarkers (from 2008 to date) and their potential screening and therapeutic values. Our search included human studies in English and found numerous novel biomarkers under research, which were categorized in 6 groups. Most of these studies are either experimental or hampered by their low numbers of patients. We concluded that currently no specific laboratory markers allow screeing for the disease and monitoring its progression or the results of treatment. Further studies and studies in larger patient groups are required in order to validate biomarkers as cost-effective tools in the AAA disease.
authors: First Department of Surgery, Vascular Unit, "Laiko" General Hospital, National and Kapodistrian University of Athens, Agiou Thoma 17, 11527 Athens, Greece.
authors: Demetrios
authors: D
authors: Moris
authors: First Department of Surgery, Vascular Unit, "Laiko" General Hospital, National and Kapodistrian University of Athens, Agiou Thoma 17, 11527 Athens, Greece.
authors: Eleftherios
authors: 0000-0003-3640-6881
authors: E
authors: Mantonakis
authors: Division of Vascular Surgery, University of Pittsburgh, Pittsburgh, PA 15213-2582, USA.
authors: Efthymios
authors: E
authors: Avgerinos
authors: Imperial College, London SW7 2AZ, UK.
authors: Marinos
authors: M
authors: Makris
authors: First Department of Surgery, Vascular Unit, "Laiko" General Hospital, National and Kapodistrian University of Athens, Agiou Thoma 17, 11527 Athens, Greece.
authors: Chris
authors: C
authors: Bakoyiannis
authors: First Department of Surgery, Vascular Unit, "Laiko" General Hospital, National and Kapodistrian University of Athens, Agiou Thoma 17, 11527 Athens, Greece.
authors: Emmanuel
authors: E
authors: Pikoulis
authors: First Department of Surgery, Vascular Unit, "Laiko" General Hospital, National and Kapodistrian University of Athens, Agiou Thoma 17, 11527 Athens, Greece.
authors: Sotirios
authors: S
authors: Georgopoulos
mesh_terms: D017544:Aortic Aneurysm, Abdominal / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male
chemical_list: D015415:Biomarkers