title: Indications, limitations and maneuvers to enable extended hepatectomy: current trends.
abstract: The liver is a solid organ with a wide variety of primary benign or malignant tumors as well as metastatic lesions. Surgical resection of these tumors remains the only curative modality. Several limitations, however, do not allow the performance of these operations. This review evaluates the indications and limitations regarding these extended hepatic resections, as well as describing all the manipulations that increase the candidates for such operations. A thorough review of the literature was performed in order to define indications for extended hepatectomy, as well as to present all methods that contribute to increasing the volume of the future remnant liver. The role of portal vein ligation, portal vein embolization, two-stage hepatectomy, and in situ liver transection are evaluated in the setting of indications and results. Extended hepatectomies are a necessity due to oncological reasons. All methods developed in order to increase the volume of the remnant liver are safe and efficient. in situ liver transection is a novel and revolutionary two-step procedure for extended hepatic resections. Further clinical studies are required to estimate long-term results and the oncological basis of this technique.
authors: Dimitrios Dimitroulis, Petros Tsaparas, Dimitrios Mantas, Eleftherios Spartalis, Charalampos Markakis, Gregory Kouraklis, Second Department of Propedeutic Surgery, Athens University Medical School, "Laiko" Hospital, 11527 Athens, Greece.
authors: Dimitrios
authors: D
authors: Dimitroulis
authors: Dimitrios Dimitroulis, Petros Tsaparas, Dimitrios Mantas, Eleftherios Spartalis, Charalampos Markakis, Gregory Kouraklis, Second Department of Propedeutic Surgery, Athens University Medical School, "Laiko" Hospital, 11527 Athens, Greece.
authors: Petros
authors: P
authors: Tsaparas
authors: Dimitrios Dimitroulis, Petros Tsaparas, Dimitrios Mantas, Eleftherios Spartalis, Charalampos Markakis, Gregory Kouraklis, Second Department of Propedeutic Surgery, Athens University Medical School, "Laiko" Hospital, 11527 Athens, Greece.
authors: Serena
authors: S
authors: Valsami
authors: Dimitrios Dimitroulis, Petros Tsaparas, Dimitrios Mantas, Eleftherios Spartalis, Charalampos Markakis, Gregory Kouraklis, Second Department of Propedeutic Surgery, Athens University Medical School, "Laiko" Hospital, 11527 Athens, Greece.
authors: Dimitrios
authors: D
authors: Mantas
authors: Dimitrios Dimitroulis, Petros Tsaparas, Dimitrios Mantas, Eleftherios Spartalis, Charalampos Markakis, Gregory Kouraklis, Second Department of Propedeutic Surgery, Athens University Medical School, "Laiko" Hospital, 11527 Athens, Greece.
authors: Eleftherios
authors: E
authors: Spartalis
authors: Dimitrios Dimitroulis, Petros Tsaparas, Dimitrios Mantas, Eleftherios Spartalis, Charalampos Markakis, Gregory Kouraklis, Second Department of Propedeutic Surgery, Athens University Medical School, "Laiko" Hospital, 11527 Athens, Greece.
authors: Charalampos
authors: C
authors: Markakis
authors: Dimitrios Dimitroulis, Petros Tsaparas, Dimitrios Mantas, Eleftherios Spartalis, Charalampos Markakis, Gregory Kouraklis, Second Department of Propedeutic Surgery, Athens University Medical School, "Laiko" Hospital, 11527 Athens, Greece.
authors: Gregory
authors: G
authors: Kouraklis
mesh_terms: D004621:Embolization, Therapeutic / Q000639:trends; D006498:Hepatectomy / Q000009:adverse effects / Q000379:methods / Q000639:trends*; D006801:Humans; D008026:Ligation; D008113:Liver Neoplasms / Q000098:blood supply* / Q000473:pathology / Q000601:surgery*; D011169:Portal Vein / Q000601:surgery*; D016896:Treatment Outcome
keywords: Extended hepatectomy; Portal vein ligation; Remnant liver volume