title: Immunological deregulation in classic hodgkin lymphoma.
abstract: Classic Hodgkin Lymphoma (cHL) has a unique histology since only a few neoplastic cells are surrounded by inflammatory accessory cells that in the last years have emerged as crucial players in sustaining the course of disease. In addition, recent studies suggest that the abnormal activity of these inflammatory cells (such as deregulation in regulatory T cells signaling, expansion of myeloid derived suppressor cells, HLA-G signaling and natural killer cells dysfunction) may have prognostic significance. This review is focused on summarizing recent advanced in immunological defects in cHL with translational implications.
authors: Division of Haematology, Azienda Ospedaliera "Policlinico-Vittorio Emanuele", University of Catania. Via Citelli 6, 95124 Catania, Italy.
authors: Alessandra
authors: A
authors: Romano
authors: Division of Haematology, Azienda Ospedaliera "Policlinico-Vittorio Emanuele", University of Catania. Via Citelli 6, 95124 Catania, Italy.
authors: Calogero
authors: C
authors: Vetro
authors: Hematology Unit, Department of Medical Sciences "Mario Aresu," University of Cagliari, Italy.
authors: Giovanni
authors: G
authors: Caocci
authors: Hematology Unit, Department of Medical Sciences "Mario Aresu," University of Cagliari, Italy.
authors: Marianna
authors: M
authors: Greco
authors: Division of Haematology, Azienda Ospedaliera "Policlinico-Vittorio Emanuele", University of Catania. Via Citelli 6, 95124 Catania, Italy.
authors: Nunziatina Laura
authors: NL
authors: Parrinello
authors: Division of Haematology, Azienda Ospedaliera "Policlinico-Vittorio Emanuele", University of Catania. Via Citelli 6, 95124 Catania, Italy.
authors: Francesco
authors: F
authors: Di Raimondo
authors: Hematology Unit, Department of Medical Sciences "Mario Aresu," University of Cagliari, Italy.
authors: Giorgio
authors: G
authors: La Nasa