title: Chemoradiation related acute morbidity in carcinoma cervix and correlation with hematologic toxicity: a South Indian prospective study.
abstract: OBJECTIVE
  To assess chemoradiation related acute morbidity in women with carcinoma cervix and to find and correlation between hematologic toxicity and organ system specific damage.
  
  
  METHODS
  A prospective study was carried out between August 2012 and July 2013 enrolling 79 women with cancer cervix receiving chemo-radiotherapy. Weekly assessment of acute morbidity was done using the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) version 4 and the toxicities were graded.
  
  
  RESULTS
  Anemia [77 (97.5%)], vomiting [75 (94.8%)] and diarrhea [72 (91.1%)], leukopenia [11 (13.9%)], cystitis [28 (35.4%], dermatitis [19 (24.1%)] and fatigue [29 (36.71%)] were the acute toxicities noted. The toxicities were most severe in 3rd and 5th week. All women could complete radiotherapy except two due to causes unrelated to radiation morbidity; seven (8.86%) had to discontinue chemotherapy due to leukopenia and intractable diarrhea. Though there was no correlation between anemia and other toxicities, it was found that all with leukopenia had diarrhea.
  
  
  CONCLUSIONS
  Chemoradiation for cancer cervix is on the whole well tolerated. Leukopenia and severe diarrhea were the acute toxicities that compelled discontinuation of chemotherapy in two women. Though anemia had no correlation with gastrointestinal toxicity, all of those with leukopenia had diarrhea.
authors: Department of Obstetrics Gynecology, Kasturba Medical College, Manipal, India E-mail : shyamala_doc@yahoo.co.in, shyamalarajgopal@hotmail.com.
authors: Aswathy
authors: A
authors: Kumaran
authors: Shyamala
authors: S
authors: Guruvare
authors: Krishna
authors: K
authors: Sharan
authors: Lavanya
authors: L
authors: Rai
authors: Shripad
authors: S
authors: Hebbar
mesh_terms: D000328:Adult; D002277:Carcinoma / Q000188:drug therapy / Q000532:radiotherapy*; D002584:Cervix Uteri / Q000528:radiation effects*; D059248:Chemoradiotherapy / Q000009:adverse effects*; D002945:Cisplatin / Q000627:therapeutic use; D003131:Combined Modality Therapy / Q000379:methods; D003967:Diarrhea / Q000209:etiology; D005260:Female; D006801:Humans; D007194:India; D007970:Leukopenia / Q000209:etiology; D008875:Middle Aged; D011446:Prospective Studies; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*
chemical_list: D002945:Cisplatin