title: Assessment of Myocardial Contractile Function Using Global and Segmental Circumferential Strain following Intracoronary Stem Cell Infusion after Myocardial Infarction: MRI Feature Tracking Feasibility Study.
abstract: Background. Magnetic resonance imaging (MRI) strain analysis is a sensitive method to assess myocardial function. Our objective was to define the feasibility of MRI circumferential strain (ε cc) analysis in assessing subtle changes in myocardial function following stem cell therapy. Methods and Results. Patients in the Amorcyte Phase I trial were randomly assigned to treatment with either autologous bone-marrow-derived stem cells infused into the infarct-related artery 5 to 11 days following primary PCI or control. MRI studies were obtained at baseline, 3, and 6 months. ε cc was measured in the short axis views at the base, mid and apical slices of the left ventricle (LV) for each patient (13 treatments and 10 controls). Mid-anterior LV ε cc improved between baseline -18.5 ± 8.6 and 3 months -22.6 ± 7.0, P = 0.03. There were no significant changes in ε cc at 3 months and 6 months compared to baseline for other segments. There was excellent intraobserver and interobserver agreement for basal and mid circumferential strain. Conclusion. MRI segmental strain analysis is feasible in assessment of regional myocardial function following cell therapy with excellent intra- and inter-observer variability's. Using this method, a modest interval change in segmental ε cc was detected in treatment group.
authors: University of Cincinnati Hospital, Cincinnati, OH, USA.
authors: Sabha
authors: S
authors: Bhatti
authors: Duke University School of Medicine, Durham, NC, USA.
authors: Hussein
authors: H
authors: Al-Khalidi
authors: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
authors: Kan
authors: K
authors: Hor
authors: University of Cincinnati Hospital, Cincinnati, OH, USA.
authors: Abdul
authors: A
authors: Hakeem
authors: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
authors: Michael
authors: M
authors: Taylor
authors: Emory University, Atlanta, GA, USA.
authors: Arshed A
authors: AA
authors: Quyyumi
authors: Emory University, Atlanta, GA, USA.
authors: John
authors: J
authors: Oshinski
authors: Amorcyte Inc., Hackensack, NJ, USA.
authors: Andrew L
authors: AL
authors: Pecora
authors: The Christ Hospital Heart and Vascular Center, Suite 138, 2123 Auburn Avenue, Cincinnati, OH 45219, USA.
authors: Dean
authors: D
authors: Kereiakes
authors: The Christ Hospital Heart and Vascular Center, Suite 138, 2123 Auburn Avenue, Cincinnati, OH 45219, USA.
authors: Eugene
authors: E
authors: Chung
authors: University of Trieste, Trieste, Italy.
authors: Gianni
authors: G
authors: Pedrizzetti
authors: Center for Diagnosis Prevention and Telemedicine, John Paul II Hospital, Krakow, Poland.
authors: Tomasz
authors: T
authors: Miszalski-Jamka
authors: The Christ Hospital Heart and Vascular Center, Suite 138, 2123 Auburn Avenue, Cincinnati, OH 45219, USA.
authors: Wojciech
authors: W
authors: Mazur