title: Relationship between impulsivity, prefrontal anticipatory activation, and striatal dopamine release during rewarded task performance.
abstract: Impulsivity, and in particular the negative urgency aspect of this trait, is associated with poor inhibitory control when experiencing negative emotion. Individual differences in aspects of impulsivity have been correlated with striatal dopamine D2/D3 receptor availability and function. This multi-modal pilot study used both positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) to evaluate dopaminergic and neural activity, respectively, using modified versions of the monetary incentive delay task. Twelve healthy female subjects underwent both scans and completed the NEO Personality Inventory Revised to assess Impulsiveness (IMP). We examined the relationship between nucleus accumbens (NAcc) dopaminergic incentive/reward release, measured as a change in D2/D3 binding potential between neutral and incentive/reward conditions with [(11)C]raclopride PET, and blood oxygen level-dependent (BOLD) activation elicited during the anticipation of rewards, measured with fMRI. Left NAcc incentive/reward dopaminergic release correlated with anticipatory reward activation within the medial prefrontal cortex (mPFC), left angular gyrus, mammillary bodies, and left superior frontal cortex. Activation in the mPFC negatively correlated with IMP and mediated the relationship between IMP and incentive/reward dopaminergic release in left NAcc. The mPFC, with a regulatory role in learning and valuation, may influence dopamine incentive/reward release.
authors: Department of Psychology and Neuroscience, University of Colorado, Boulder, CO, USA; Department of Psychiatry, The University of Michigan, Ann Arbor, MI, USA. Electronic address: barbara.weiland@colorado.edu.
authors: Barbara J
authors: BJ
authors: Weiland
authors: Department of Psychiatry, The University of Michigan, Ann Arbor, MI, USA.
authors: Mary M
authors: MM
authors: Heitzeg
authors: Department of Psychiatry, Vanderbilt University, Nashville, TN, USA.
authors: David
authors: D
authors: Zald
authors: Department of Psychiatry, The University of Michigan, Ann Arbor, MI, USA.
authors: Chelsea
authors: C
authors: Cummiford
authors: Department of Psychiatry, The University of Michigan, Ann Arbor, MI, USA.
authors: Tiffany
authors: T
authors: Love
authors: Department of Psychiatry, The University of Michigan, Ann Arbor, MI, USA.
authors: Robert A
authors: RA
authors: Zucker
authors: Department of Psychiatry, The University of Michigan, Ann Arbor, MI, USA.
authors: Jon-Kar
authors: JK
authors: Zubieta
mesh_terms: D000328:Adult; D059031:Anticipation, Psychological; D002250:Carbon Radioisotopes; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D018492:Dopamine Antagonists; D005260:Female; D006801:Humans; D007175:Impulsive Behavior / Q000378:metabolism / Q000503:physiopathology; D007182:Income; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D017072:Neostriatum / Q000378:metabolism; D009714:Nucleus Accumbens / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D049268:Positron-Emission Tomography; D017397:Prefrontal Cortex / Q000378:metabolism / Q000503:physiopathology*; D020891:Raclopride; D017448:Receptors, Dopamine D2 / Q000187:drug effects / Q000378:metabolism; D050637:Receptors, Dopamine D3 / Q000187:drug effects / Q000378:metabolism; D012201:Reward; D013647:Task Performance and Analysis
chemical_list: D002250:Carbon Radioisotopes; D018492:Dopamine Antagonists; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D020891:Raclopride; D004298:Dopamine
keywords: Dopamine; NAcc; PET; Reward; fMRI; mPFC