title: Prostatic and testicular parameters in lepromatous patients.
abstract: OBJECTIVE
  To evaluate PSA (Prostate-specific antigen) parameters in patients with lepromatous leprosy (LL).
  
  
  METHODS
  In a retrospective study, 23 male patients with LL were evaluated. PSA parameters (serum total PSA (tPSA), free PSA (fPSA), free-to-total PSA ratio (f/tPSA), PSA Density (PSAD)) were assessed. PSA parameters were compared with a control group.
  
  
  RESULTS
  The mean tPSA, fPSA, f/tPSA, prostate volume, and PSAD values of the patient group with LL were 1.87 +/- 0.81 ng/ml, 0.67 +/- 0.29 ng/ml, 0.36 +/- 0.11, 41.08 +/- 23.65 ml and 0.055 +/- 0.037, respectively. The mean tPSA, fPSA, f/tPSA, prostate volume, and PSAD values of the control group were 2.71 +/- 0.91 ng/ml, 0.80 +/- 0.34 ng/ml, 0.30 +/- 0.08, 65.0 +/- 28.73 ml and 0.049 +/- 0.028, respectively. The mean tPSA and prostate volume values were found to be significantly lower in the patient group with LL (p = 0.002 and 0.004, respectively). No significant difference was found between two groups in terms of mean fPSA and PSAD values (p = 0.18 and 0.5, respectively). The mean f/tPSA value was found to be significantly higher in the patient group with LL (p = 0.02). Testes in 16 (69%) patients with LL were bilaterally atrophic.
  
  
  CONCLUSIONS
  Serum tPSA values and prostate volumes in the patients with LL were significantly reduced and f/tPSA values were significantly increased. Testicular atrophy in the lepromatous cases might be due to leprosy-related orchitis and associated with a reduction in prostatic volume.
authors: Erdogan
authors: E
authors: Aglamis
authors: Cemal
authors: C
authors: Tasdemir
authors: Mehmet Ozgur
authors: MO
authors: Yucel
authors: Cavit
authors: C
authors: Ceylan
authors: Ilker
authors: I
authors: Erden
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D015440:Leprosy, Lepromatous / Q000097:blood / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D009929:Organ Size; D011467:Prostate / Q000254:growth & development / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood*; D012189:Retrospective Studies; D013737:Testis / Q000473:pathology*
chemical_list: D017430:Prostate-Specific Antigen