title: Thermally modulated photoacoustic imaging with super-paramagnetic iron oxide nanoparticles.
abstract: Thermally modulated photoacoustic imaging (TMPI) is reported here for contrast enhancement when using nanoparticles as contrast agents. Exploiting the excellent sensitivity of the photoacoustic (PA) process on temperature and the highly selective heating capability of nanoparticles under electromagnetic field, the PA signals stemming from the nanoparticles labeled region can be efficiently modulated whereas those from highly light absorptive backgrounds are minimally affected. A coherent difference imaging procedure reduces the background signal and thus improves the imaging contrast. Phantom experiments with super-paramagnetic iron oxide nanoparticles (SPIONs) as contrast agents and alternating magnetic fields for heating are demonstrated. Further improvements toward clinical applications are also discussed.
authors: Xiaohua
authors: X
authors: Feng
authors: Fei
authors: F
authors: Gao
authors: Yuanjin
authors: Y
authors: Zheng
mesh_terms: D003287:Contrast Media; D003952:Diagnostic Imaging / Q000379:methods / Q000706:statistics & numerical data; D006358:Hot Temperature; D058185:Magnetite Nanoparticles; D017711:Nonlinear Dynamics; D055620:Optical Phenomena; D019047:Phantoms, Imaging; D061088:Photoacoustic Techniques / Q000379:methods* / Q000706:statistics & numerical data
chemical_list: D003287:Contrast Media; D058185:Magnetite Nanoparticles