title: The synthesis of well-defined heparin and heparan sulfate fragments.
abstract: Heparin and heparan sulfate are key players in a plethora of physiological processes. Organic synthesis is the method of choice for the production of these oligosaccharides and their derivatives and analogues. The highly complex structure of these polysaccharides presents a formidable synthetic challenge and the incorporation of the full array of variations in oligosaccharides of significant length is a daunting task. This review records the development of strategies to access these exciting biomolecules.:
authors: Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands (http://www.leidenuniv.nl/).
authors: Jeroen D C
authors: JD
authors: Codée
authors: Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands (http://www.leidenuniv.nl/).
authors: Herman S
authors: HS
authors: Overkleeft
authors: Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands (http://www.leidenuniv.nl/).
authors: Gijsbert A
authors: GA
authors: van der Marel
authors: Medicinal Chemistry, Organon N.V., P.O. Box 20, 5340 BH Oss, The Netherlands (http://www.organon.nl/). Electronic address:stan.vanboeckel@organon.com.
authors: Constant A A
authors: CA
authors: van Boeckel