title: Immunology of Taenia solium taeniasis and human cysticercosis.
abstract: The life cycle of Taenia solium, the pork tapeworm, is continuously closed in many rural settings in developing countries when free roaming pigs ingest human stools containing T. solium eggs and develop cysticercosis, and humans ingest pork infected with cystic larvae and develop intestinal taeniasis, or may also accidentally acquire cysticercosis by faecal-oral contamination. Cysticercosis of the human nervous system, neurocysticercosis, is a major cause of seizures and other neurological morbidity in most of the world. The dynamics of exposure, infection and disease as well as the location of parasites result in a complex interaction which involves immune evasion mechanisms and involutive or progressive disease along time. Moreover, existing data are limited by the relative lack of animal models. This manuscript revises the available information on the immunology of human taeniasis and cysticercosis.
authors: Department of Microbiology, School of Sciences and Center for Global Health - Tumbes, Universidad Peruana Cayetano Heredia, Lima, Peru; Cysticercosis Unit, Instituto Nacional de Ciencias Neurologicas, Lima, Peru.
authors: H H
authors: HH
authors: Garcia
authors: S
authors: S
authors: Rodriguez
authors: J S
authors: JS
authors: Friedland
mesh_terms: D000818:Animals; D003551:Cysticercosis / Q000276:immunology / Q000635:transmission; D006790:Host-Parasite Interactions / Q000276:immunology; D006801:Humans; D008018:Life Cycle Stages; D008460:Meat / Q000469:parasitology*; D013552:Swine; D013553:Swine Diseases / Q000276:immunology / Q000469:parasitology*; D041201:Taenia solium / Q000254:growth & development / Q000276:immunology*; D013622:Taeniasis / Q000276:immunology / Q000473:pathology / Q000635:transmission / Q000662:veterinary*
keywords: Peru; Taenia solium; cysticercosis; neurocysticercosis; parasitic infections; seizures