title: Population genetics for target identification.
abstract: In this review, we address how to best use data from the Human Genome Project to discover new drug targets for common disease. We focus on population genetic approaches to identify variants associated with disease and how these can illuminate new targets and pathways for intervention. We discuss new insights into patterns of human genetic variation, evolving strategies for genome-wide case-control design, and developments in bioinformatic technologies. Hypothesis versus non-hypothesis-driven approaches to target identification are considered.:
authors: Department of Molecular Neuroscience, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London, UK WC1N 3BG.
authors: Daniel G
authors: DG
authors: Healy
authors: Department of Molecular Neuroscience, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London, UK WC1N 3BG.
authors: Patrick M
authors: PM
authors: Abou-Sleiman
authors: Department of Biology, University College London, Gower Street, London, UK WCIE 6BT.
authors: David B
authors: DB
authors: Goldstein
authors: Department of Molecular Neuroscience, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London, UK WC1N 3BG. Electronic address:n.wood@ion.ucl.ac.uk.
authors: Nicholas W
authors: NW
authors: Wood