title: Catalytic asymmetric nucleophilic openings of 3-substituted oxetanes.
abstract: Asymmetric ring-opening of 3-substituted oxetanes provides rapid access to highly functionalized chiral building blocks. However, progress in this field is limited. Recently we developed a new catalytic system based on chiral Brønsted acids for this type of reaction and demonstrated the synthesis of a range of useful molecules under mild and operationally simple conditions. In this perspective, we describe the challenges, progress, and potential future efforts on this topic.
authors: Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China. sunjw@ust.hk.
authors: Zhaobin
authors: Z
authors: Wang
authors: Zhilong
authors: Z
authors: Chen
authors: Jianwei
authors: J
authors: Sun
mesh_terms: D002384:Catalysis; D003035:Cobalt / Q000737:chemistry; D004988:Ethers, Cyclic / Q000737:chemistry*; D007546:Isoquinolines / Q000737:chemistry; D008958:Models, Molecular
chemical_list: D004988:Ethers, Cyclic; D007546:Isoquinolines; D003035:Cobalt; C005287:oxetane