title: Application of ulipristal acetate in female patients with uterine fibroids.
abstract: OBJECTIVE
  Uterine fibroids are the most common benign tumors in women of reproductive age. Evidence suggest that ovarian steroid hormones, in particular, progesterone play a major role in promoting leiomyoma development and growth. For the last years there was an extensive research on selective progesterone receptor modulators and their use in therapy. Ulipristal acetate (UPA) is one of these modulators. The aim of this paper is to evaluate efficacy and safety of oral ulipristal acetate for the treatment in women with symptomatic uterine fibroids.
  
  
  METHODS
  The study group comprised five patients with uterine fibroids. All patients received 5 mg of ulipristal acetate per day for three months.
  
  
  RESULTS
  The total volume of fibroids decreased by 33-68%. In all patients during the administration of UPA significant reduction of menstrual bleeding was observed. Increase of endometrial thickness without clinical significance was observed in two patients. No significant side-effects were observed during the treatment period.
  
  
  CONCLUSIONS
  1) The volume offibroids decreased from 33 to 68%. 2) The UPA administration effectively controlled excessive bleeding. 3) Treatment with UPA may modify the scope of the surgery. 4) UPA is a well-tolerated drug.
authors: Barbara
authors: B
authors: Grzechocinska
authors: Halina
authors: H
authors: Gadomska
authors: Aleksandra
authors: A
authors: Zygula
authors: Miroslaw
authors: M
authors: Wielgos
mesh_terms: D000284:Administration, Oral; D000328:Adult; D005260:Female; D006727:Hormone Antagonists / Q000008:administration & dosage*; D006801:Humans; D007889:Leiomyoma / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D008599:Menstruation Disturbances / Q000188:drug therapy / Q000209:etiology; D008875:Middle Aged; D009649:Norpregnadienes / Q000008:administration & dosage*; D011980:Receptors, Progesterone / Q000378:metabolism; D016896:Treatment Outcome; D047368:Tumor Burden / Q000187:drug effects; D014594:Uterine Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology
chemical_list: D006727:Hormone Antagonists; D009649:Norpregnadienes; D011980:Receptors, Progesterone; C555622:ulipristal acetate