title: Quantitative correlation of the in vitro biological effect with parameters of molecular complexation in mutagen-interceptor systems.
abstract: According to the theory of interceptor-protector action a quantitative link between the physico-chemical parameters of molecular complexation and in vitro biological effect in aromatic drug-interceptor systems must exist. In the present communication such link between relative change in mutagenicity of IQ-type aromatic mutagens on addition of aromatic interceptor molecules with equilibrium hetero-association constants of mutagen-interceptor complexation has been found using the published in vitro data in bacteria cell systems.
authors: Department of Biology and Chemistry, Belgorod State University, Belgorod 308015, Russia.
authors: Anatoly S
authors: AS
authors: Buchelnikov
authors: Department of Biology and Chemistry, Belgorod State University, Belgorod 308015, Russia; Department of Physics, Sevastopol National Technical University, Sevastopol 299053, Russia. Electronic address: max_evstigneev@mail.ru.
authors: Maxim P
authors: MP
authors: Evstigneev
mesh_terms: D001419:Bacteria / Q000235:genetics / Q000378:metabolism; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D007364:Intercalating Agents / Q000737:chemistry*; D008954:Models, Biological; D008956:Models, Chemical; D009153:Mutagens / Q000737:chemistry*
chemical_list: D004269:DNA, Bacterial; D007364:Intercalating Agents; D009153:Mutagens
keywords: Hetero-association; IQ-type mutagens; Interceptor mechanism; Mutagenic test