title: The association between coronary calcification and adenomatous polyps of colon in Korean adults.
abstract: OBJECTIVE
  Adenomatous polyps of colon is a precancerous lesion. Many studies have shown that the adenomatous polyps of colon and cardiovascular disease share several common risk factors. This cross-sectional study aimed to investigate whether coronary calcification is associated with the adenomatous polyps of colon.
  
  
  METHODS
  Among 1637 Korean adults, we examined the association between coronary calcium score (CCS) as a measurement of coronary calcification and the presence of adenomatous polyps of colon via multi-detected row computed tomography (MDCT) and colonoscopy, respectively. CCS values were categorized as follows: 0, 1-17, 18-105, or≥106. The odds ratios (ORs) and 95% confidence intervals (CIs) for the presence of adenomatous polyps of colon were calculated across CCS groups.
  
  
  CONCLUSIONS
  After adjusting for confounding variables, the adjusted ORs (95% CIs) for the presence of adenomatous polyps of colon in each of the four CCS groups were 1.00 (reference), 1.44 (0.91-2.33), 1.88 (1.15-3.01) and 3.61 (2.23-5.74). And higher CCS values were associated with multiple polyps (P≤0.001), villous histologic features or high-grade dysplasia (P=0.02), and advanced adenomatous polyps (P≤0.001). A higher level of CCS was found to be strongly and independently associated with the presence of adenomatous polyps of colon in Korean adults. This finding suggests that people at high risk for coronary atherosclerosis through MDCT should be considered for further evaluation of adenomatous polyps.
authors: Myongji Hospital, GyungGi-Do Goyang City, Republic of Korea.
authors: Hong-Bae
authors: HB
authors: Kim
authors: Yongin Severance Hospital, GyungGi-Do Yongin City, Republic of Korea.
authors: Yong-Jae
authors: YJ
authors: Lee
authors: GangNam Severance Hospital, Department of Family Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors: Jae-Yong
authors: JY
authors: Shim
authors: GangNam Severance Hospital, Department of Family Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: love0614@yuhs.ac.
authors: Hye-Ree
authors: HR
authors: Lee
mesh_terms: D018256:Adenomatous Polyps / Q000150:complications* / Q000453:epidemiology; D044466:Asian People; D003111:Colonic Polyps / Q000150:complications* / Q000453:epidemiology; D003324:Coronary Artery Disease / Q000150:complications*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D061205:Vascular Calcification / Q000150:complications*