title: Oxygen-related chemoreceptor drive to breathe during H₂S infusion.
abstract: This study addresses the following question: Could the acute depression in breathing produced by hyperoxia, a reflection of the tonic drive to breathe from the arterial chemoreceptors, be accounted for by a background level of endogenous H2S? To address this question, we produced a stable but moderate increase in breathing (24±11%) via continuous infusion of low levels of H2S, in 10 spontaneously breathing urethane-sedated rats. We found that acute exposure to 100% O2 (20 tests) decreased minute ventilation (V˙(I)) from 301±51 to 210±43 ml/min within 15s in control conditions, but no additional significant drop in V˙(I) was observed during H2S induced hyperpnea. In addition, no decrease in the estimated concentrations of gaseous H2S in the arterial blood was observed during the hyperoxic tests. It is concluded that the ventilatory depression induced by high O2 appears to be limited to the tonic background peripheral chemosensory drive to breathe, but has little or no impact on the CB stimulation produced by low levels of H2S.
authors: Pennsylvania State University, College of Medicine Department of Medicine, Division of Pulmonary and Critical Care Medicine, Hershey, PA, USA. Electronic address: phaouzi@hmc.psu.edu.
authors: Philippe
authors: P
authors: Haouzi
authors: Pennsylvania State University, College of Medicine Department of Medicine, Division of Pulmonary and Critical Care Medicine, Hershey, PA, USA.
authors: Takashi
authors: T
authors: Sonobe
authors: Pennsylvania State University, College of Medicine Department of Medicine, Division of Pulmonary and Critical Care Medicine, Hershey, PA, USA.
authors: Bruno
authors: B
authors: Chenuel
mesh_terms: D000393:Air Pollutants / Q000097:blood / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D002245:Carbon Dioxide / Q000008:administration & dosage; D002628:Chemoreceptor Cells / Q000187:drug effects*; D006862:Hydrogen Sulfide / Q000097:blood / Q000494:pharmacology*; D018496:Hyperoxia; D000860:Hypoxia / Q000503:physiopathology; D008297:Male; D010100:Oxygen / Q000008:administration & dosage / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012119:Respiration / Q000187:drug effects*; D013997:Time Factors
chemical_list: D000393:Air Pollutants; D002245:Carbon Dioxide; D010100:Oxygen; D006862:Hydrogen Sulfide
keywords: Arterial chemoreflex; Dejours test; Hydrogen sulfide