title: [Correlation between urinary catecholamines dosage and apnea-hypopnea index in a hypertension population: pilot study].
abstract: OBJECTIVE
  Sleep disorders like obstructive sleep apnea in adults are associated with increased sympathetic activity, which induced high blood pressure and could be associated with resistant hypertension. Some studies have demonstrated that high urinary catecholamine levels in obstructive sleep apnea patients may be decreased with continuous positive airway pressure therapy. However, very few studies have demonstrated a correlation between apnea-hypopnea index and urinary catecholamine levels in hypertension patients.
  
  
  METHODS
  In this pilot study, 20 hypertensive patients referred for hypertension work-up including night-time polygraphy and 24h urinary catecholamine dosage were included.
  
  
  RESULTS
  Mean age was 51±11 years (30-76), 68% were males. Diagnosis of obstructive sleep apnea was confirmed in 13 patients at the end of the work-up. Mean apnea-hypopnea index was 14±9 (2-32). The only urinary catecholamine parameter significantly increased in patients with obstructive sleep apnea was 24h urinary normetanephrine (1931±1285 vs 869±293nmol/24h; P<0.05). However, this difference was not significant when this parameter was adjusted to 24h urinary creatinine. We observed a significant positive correlation between AHI and 24h urinary normetanephine (r=0.486; P=0.035).
  
  
  CONCLUSIONS
  This pilot study confirms an isolated elevation of 24h urinary normetanephrine in hypertensive patients with obstructive sleep apnea and shows a significant correlation between sleep disorders expressed by apnea-hypopnea index and urinary catecholamines excretion.
authors: Service de médecine interne, université Paris XIII, hôpital Avicenne, Assistance publique-Hôpitaux de Paris, 125, rue de Stalingrad, 93009 Bobigny cedex, France. Electronic address: marilucy.lopez-sublet@avc.aphp.fr.
authors: M
authors: M
authors: Lopez-Sublet
authors: Service de médecine interne, université Paris XIII, hôpital Avicenne, Assistance publique-Hôpitaux de Paris, 125, rue de Stalingrad, 93009 Bobigny cedex, France.
authors: S
authors: S
authors: Le Jeune
authors: Service de médecine interne, université Paris XIII, hôpital Avicenne, Assistance publique-Hôpitaux de Paris, 125, rue de Stalingrad, 93009 Bobigny cedex, France.
authors: B
authors: B
authors: Giroux-Leprieur
authors: Service de médecine interne, université Paris XIII, hôpital Avicenne, Assistance publique-Hôpitaux de Paris, 125, rue de Stalingrad, 93009 Bobigny cedex, France.
authors: D
authors: D
authors: Agnoletti
authors: Service de médecine interne, université Paris XIII, hôpital Avicenne, Assistance publique-Hôpitaux de Paris, 125, rue de Stalingrad, 93009 Bobigny cedex, France.
authors: R
authors: R
authors: Dhote
authors: Service de médecine interne, université Paris XIII, hôpital Avicenne, Assistance publique-Hôpitaux de Paris, 125, rue de Stalingrad, 93009 Bobigny cedex, France.
authors: J J
authors: JJ
authors: Mourad
mesh_terms: D000328:Adult; D000368:Aged; D001049:Apnea; D015415:Biomarkers / Q000652:urine; D015992:Body Mass Index; D002395:Catecholamines / Q000652:urine*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000175:diagnosis* / Q000652:urine; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011237:Predictive Value of Tests; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000175:diagnosis* / Q000652:urine
chemical_list: D015415:Biomarkers; D002395:Catecholamines
keywords: Apnée du sommeil; Arterial hypertension; Dérivés méthoxylés urinaires; Hypertension artérielle; Obstructive sleep apnea; Urinary catecholamines