title: Direct comparison of solid-phase gastric emptying times assessed by means of a carbon isotope-labeled sodium acetate breath test and technetium Tc 99m albumin colloid radioscintigraphy in healthy cats.
abstract: OBJECTIVE
  To directly compare solid-phase gastric emptying times assessed by means of a [(13)C]sodium acetate breath test ([(13)C]-SABT) and technetium Tc 99m albumin colloid radioscintigraphy ((99m)Tc-ACR) in healthy cats.
  
  
  METHODS
  12 healthy cats.
  
  
  METHODS
  After ingestion of a test meal containing 50 mg of [(13)C]sodium acetate and 250 MBq of (99m)Tc-albumin colloid, each cat underwent simultaneous [(13)C]-SABT and (99m)Tc-ACR on 2 consecutive days. Breath samples and scintigrams were acquired at 30, 60, 90, 120, 150, 180, 210, 240, 300, 360, 480, and 600 minutes after meal ingestion. Quartiles of gastric emptying (25%, 50%, and 75%) were calculated for breath test analysis by use of the area under the curve of the (13)C:(12)C ratio. Quartiles of gastric emptying times were extrapolated from the scintigraphic findings by beans of nonlinear curve regression analysis.
  
  
  RESULTS
  Mean ± SD gastric half-emptying (50%) times obtained with [(13)C]-SABT and (99m)Tc-ACR, were 239 ± 28 minutes and 276 ± 59 minutes, respectively. A 2-way repeated-measures ANOVA revealed that mean gastric emptying times determined with [(13)C]-SABT and (99m)Tc-ACR differed significantly. For the stages of gastric emptying, Pearson correlation between the 2 methods was good at 25% (r = 0.655) and weak at 50% (r = 0.588) and 75% (r = 0.566)of gastric emptying.
  
  
  CONCLUSIONS
  Results indicated that the [(13)C]-SABT can be a valid alternative to (99m)Tc-ACR in healthy cats; it was easy to perform, was tolerated well by the cats, and had acceptable correlation to scintigraphic findings at gastric emptying of 25%, 50% and 75%. Studies in cats with delayed gastric emptying will be needed to verify the validity of the [(13)C]-SABT.
authors: Department for Internal Medicine of the Small Animal Hospital, Justus-Liebig-University, 35392 Giessen, Germany.
authors: Silke
authors: S
authors: Schmitz
authors: Birte
authors: B
authors: Götte
authors: Christian
authors: C
authors: Borsch
authors: Clemens
authors: C
authors: Kunz
authors: Klaus
authors: K
authors: Failing
authors: Reto
authors: R
authors: Neiger
mesh_terms: D000818:Animals; D001944:Breath Tests / Q000379:methods*; D002247:Carbon Isotopes; D002415:Cats / Q000502:physiology*; D005260:Female; D005746:Gastric Emptying / Q000502:physiology*; D008297:Male; D011877:Radionuclide Imaging / Q000379:methods / Q000662:veterinary*; D019346:Sodium Acetate / Q000737:chemistry / Q000378:metabolism*; D013668:Technetium Tc 99m Aggregated Albumin; D013997:Time Factors
chemical_list: D002247:Carbon Isotopes; D013668:Technetium Tc 99m Aggregated Albumin; D019346:Sodium Acetate