title: Computational analysis of mRNA expression profiles identifies the ITG family and PIK3R3 as crucial genes for regulating triple negative breast cancer cell migration.
abstract: Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer that does not express estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor (Her2/neu). TNBC has worse clinical outcomes than other breast cancer subtypes. However, the key molecules and mechanisms of TNBC migration remain unclear. In this study, we compared two normalized microarray datasets from GEO database between Asian (GSE33926) and non-Asian populations (GSE46581) to determine the molecules and common pathways in TNBC migration. We demonstrated that 16 genes in non-Asian samples and 9 genes in Asian samples are related to TNBC migration. In addition, our analytic results showed that 4 genes, PIK3R3, ITGB1, ITGAL, and ITGA6, were involved in the regulation of actin cytoskeleton. Our results indicated potential genes that link to TNBC migration. This study may help identify novel therapeutic targets for drug development in cancer therapy.
authors: Department of Clinical Pharmacy, Taipei Medical University, Taipei 110, Taiwan.
authors: Sukhontip
authors: 0000-0001-9823-0733
authors: S
authors: Klahan
authors: Department of Clinical Pharmacy, Taipei Medical University, Taipei 110, Taiwan.
authors: Mei-Shin
authors: 0000-0001-6544-1163
authors: MS
authors: Wu
authors: Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
authors: Edward
authors: 0000-0002-8272-6707
authors: E
authors: Hsi
authors: Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei 106, Taiwan ; Cathay General Hospital SiJhih, New Taipei 221, Taiwan ; School of Medicine, Fu-Jen Catholic University, New Taipei 242, Taiwan ; School of Medicine, Taipei Medical University, Taipei 110, Taiwan.
authors: Chi-Cheng
authors: 0000-0003-4378-4776
authors: CC
authors: Huang
authors: Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan ; Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan ; Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 801, Taiwan.
authors: Ming-Feng
authors: MF
authors: Hou
authors: Department of Clinical Pharmacy, Taipei Medical University, Taipei 110, Taiwan ; Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan ; Department of Pharmacy, Taipei Medical University-Wan Fang Hospital, Taipei 116, Taiwan ; Master Program for Clinical Pharmacogenomics and Pharmacoproteomics, School of Pharmacy, Taipei Medical University, Taipei 110, Taiwan.
authors: Wei-Chiao
authors: WC
authors: Chang
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D002465:Cell Movement / Q000235:genetics*; D019295:Computational Biology / Q000379:methods*; D057225:Data Mining; D003710:Demography; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D053263:Gene Regulatory Networks / Q000235:genetics; D006801:Humans; D016023:Integrins / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics* / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics; D012984:Software; D064726:Triple Negative Breast Neoplasms / Q000235:genetics* / Q000473:pathology*
chemical_list: D016023:Integrins; D019869:Phosphatidylinositol 3-Kinases; D012333:RNA, Messenger; C523442:PIK3R3 protein, human