title: No clinical benefit of gender-specific total knee arthroplasty.
abstract: OBJECTIVE
  There is no consensus regarding the clinical relevance of gender-speciﬁc prostheses in total knee arthroplasty (TKA). We summarize the current best evidence in a comparison of clinical and radiographic outcomes between gender-speciﬁc prostheses and standard unisex prostheses in female patients.
  
  
  METHODS
  We used the PubMed, Embase, Cochrane, Science Citation Index, and Scopus databases. We included randomized controlled trials published up to January 2013 that compared gender-speciﬁc prostheses with standard unisex prostheses in female patients who underwent primary TKAs.
  
  
  RESULTS
  6 trials involving 423 patients with 846 knee joints met the inclusion criteria. No statistically significant differences were observed between the 2 designs regarding pain, range of motion (ROM), knee scores, satisfaction, preference, complications, and radiographic results. The gender-specific design (Gender Solutions; Zimmer Inc, Warsaw, Indiana) reduced the prevalence of overhang. However, it had less overall coverage of the femoral condyles compared to the unisex group. In fact, the femoral prosthesis in the standard unisex group matched better than that in the gender-speciﬁc group.
  
  
  CONCLUSIONS
  Gender-speciﬁc prostheses do not appear to confer any beneﬁt in terms of clinician- and patient-reported outcomes for the female knee.
authors: Department of Orthopaedic Surgery , Shanghai Jiao Tong University Affiliated Sixth People's Hospital.
authors: Tao
authors: T
authors: Cheng
authors: Chen
authors: C
authors: Zhu
authors: Jiaxing
authors: J
authors: Wang
authors: Mengqi
authors: M
authors: Cheng
authors: Xiaochun
authors: X
authors: Peng
authors: Qi
authors: Q
authors: Wang
authors: Xianlong
authors: X
authors: Zhang
mesh_terms: D019645:Arthroplasty, Replacement, Knee / Q000379:methods*; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D007720:Knee Prosthesis; D008297:Male; D011474:Prosthesis Design / Q000379:methods*; D016032:Randomized Controlled Trials as Topic; D012737:Sex Factors