title: Alternative expression pattern of MALT1-A20-NF-κB in patients with rheumatoid arthritis.
abstract: Rheumatoid arthritis (RA) is an inflammatory autoimmune disorder; abnormal T cell immunity plays a critical role in the development of RA. Recently, A20 was identified as a key negative regulator for T cell activation and inflammatory signaling and may be involved in RA pathogenesis. In this study, we analyzed the expression level of A20, NF-κB, and A20 regulatory factor mucosa-associated lymphoid tissue lymphoma translocation gene 1 (MALT1) in patients with RA. Real-time PCR was used to determine the expression level of MALT1, MALT-V1, A20, and NF-κB genes in RA and healthy individuals (HI). Significantly lower A20 expression was found in RA patients compared with those in the healthy group, while NF-κB overexpression could be detected in patients with RA. Moreover, the MALT1 and MALT1-V1 expression level was downregulated in RA patients. A positive correlation between MALT1 and A20 and MALT1-V1 and A20 was found in patients with RA, and a tendency towards a negative correlation was found between MALT1 and NF-κB, MALT1-V1 and NF-κB, and A20 and NF-κB. In conclusion, we first characterized the alternative expression pattern of MALT1, A20, and NF-κB in RA, which may be related to abnormal T cell activation.
authors: Institute of Hematology, Jinan University, Guangzhou 510632, China ; Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou 510632, China.
authors: Xu
authors: X
authors: Wang
authors: Institute of Hematology, Jinan University, Guangzhou 510632, China ; Department of Rheumatism and Immunology, First Hospital Affiliated, Jinan University, Guangzhou 510632, China.
authors: Lihua
authors: L
authors: Zhu
authors: Institute of Hematology, Jinan University, Guangzhou 510632, China.
authors: Ziwei
authors: Z
authors: Liao
authors: Institute of Hematology, Jinan University, Guangzhou 510632, China.
authors: Fan
authors: F
authors: Zhang
authors: Institute of Hematology, Jinan University, Guangzhou 510632, China.
authors: Ling
authors: L
authors: Xu
authors: Institute of Hematology, Jinan University, Guangzhou 510632, China ; Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou 510632, China.
authors: Yan
authors: Y
authors: Xu
authors: Institute of Hematology, Jinan University, Guangzhou 510632, China.
authors: Shaohua
authors: S
authors: Chen
authors: Institute of Hematology, Jinan University, Guangzhou 510632, China.
authors: Lijian
authors: L
authors: Yang
authors: Department of Rheumatism and Immunology, First Hospital Affiliated, Jinan University, Guangzhou 510632, China.
authors: Yi
authors: Y
authors: Zhou
authors: Institute of Hematology, Jinan University, Guangzhou 510632, China ; Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou 510632, China ; Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Jinan University, Guangzhou 510632, China.
authors: Yangqiu
authors: Y
authors: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D016022:Case-Control Studies; D020169:Caspases / Q000235:genetics* / Q000276:immunology; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000276:immunology; D005260:Female; D015870:Gene Expression; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics* / Q000276:immunology; D007527:Isoenzymes / Q000235:genetics / Q000276:immunology; D008213:Lymphocyte Activation; D008875:Middle Aged; D000074884:Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein; D016328:NF-kappa B / Q000235:genetics* / Q000276:immunology; D009363:Neoplasm Proteins / Q000235:genetics* / Q000276:immunology; D009687:Nuclear Proteins / Q000235:genetics* / Q000276:immunology; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology; D000072598:Tumor Necrosis Factor alpha-Induced Protein 3
chemical_list: D004268:DNA-Binding Proteins; D047908:Intracellular Signaling Peptides and Proteins; D007527:Isoenzymes; D016328:NF-kappa B; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; C076529:TNFAIP3 protein, human; D000072598:Tumor Necrosis Factor alpha-Induced Protein 3; D020169:Caspases; C400109:MALT1 protein, human; D000074884:Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein