title: [Effects of carbamazepine on plasma concentrations of valproic acid and its toxic metabolite in epileptic patients].
abstract: To investigate the effects of carbamazepine (CBZ) on the plasma concentrations of valproic acid (VPA) and its toxic metabolite 2-propyl-4-pentenoic acid (4-ene VPA) in epileptic patients, the plasma concentrations of VPA and 4-ene VPA were determined, and the effect of CBZ on pharmacokinetics of VPA was evaluated. All patients had been divided into two groups (VPA group, n = 87; and VPA+CBZ group, n = 19). As compared to VPA group, the combination of CBZ significantly (P < 0.01) decreased the trough concentration of VPA [VPA group, (69.5 +/- 28.8) microg x mL(-1); VPA+CBZ group, (46.3 +/- 25.6) microg x mL(-1)] and does-adjusted VPA trough concentration [VPA group, (4.89 +/- 2.21) microg x mL(-1) x mg(-1) x kg(-1); VPA+CBZ group, (3.14 +/- 1.74) microg x mL(-1) x mg(-1) x kg(-1)]. However, the addition of CBZ did not influence the concentration of 4-ene VPA. The present study revealed that coadministration of CBZ can reduce VPA plasma concentration and may impact VPA clinical effect, therefore therapeutic drug mornitoring of VPA should be used when combined use of CBZ and VPA.
authors: Zhuo-Jia
authors: ZJ
authors: Chen
authors: Xue-Ding
authors: XD
authors: Wang
authors: Lie-Min
authors: LM
authors: Zhou
authors: Zi-Yan
authors: ZY
authors: Fang
authors: Hong-Sheng
authors: HS
authors: Wang
authors: Jia-Li
authors: JL
authors: Li
authors: Jue-Qian
authors: JQ
authors: Zhou
authors: Hong-Bing
authors: HB
authors: Huang
authors: Min
authors: M
authors: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use; D002220:Carbamazepine / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000097:blood* / Q000188:drug therapy; D005229:Fatty Acids, Monounsaturated / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D014635:Valproic Acid / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000927:Anticonvulsants; D005229:Fatty Acids, Monounsaturated; C045022:2-propyl-4-pentenoic acid; D002220:Carbamazepine; D014635:Valproic Acid