title: Chondroitin sulfate proteoglycans: structure-function relationship with implication in neural development and brain disorders.
abstract: Chondroitin sulfate proteoglycans (CSPGS) are extracellular matrix components that contain two structural parts with distinct functions: a protein core and glycosaminoglycan (GAG) side chains. CSPGs are known to be involved in important cell processes like cell adhesion and growth, receptor binding, or cell migration. It is recognized that the presence of CSPGs is critical in neuronal growth mechanisms including axon guidance following injury of nervous system components such as spinal cord and brain. CSPGs are upregulated in the central nervous system after injury and participate in the inhibition of axon regeneration mainly through their GAG side chains. Recently, it was shown that some CSPGs members like aggrecan, versican, and neurocan were strongly involved in brain disorders like bipolar disorder (BD), schizophrenia, and ADHD. In this paper, we present the chemical structure-biological functions relationship of CSPGs, both in health state and in genetic disorders, addressing methods represented by genome-wide and crystallographic data as well as molecular modeling and quantitative structure-activity relationship.
authors: Anatomy, Animal Physiology and Biophysics Department, Faculty of Biology, University of Bucharest, 91-95th Independentei Street, 050095 Bucharest, Romania.
authors: Speranta
authors: 0000-0002-4245-2502
authors: S
authors: Avram
authors: Norgenotech AS, Totenvegen 2049, 2848 Skreia, Norway.
authors: Sergey
authors: S
authors: Shaposhnikov
authors: Anatomy, Animal Physiology and Biophysics Department, Faculty of Biology, University of Bucharest, 91-95th Independentei Street, 050095 Bucharest, Romania ; Automatic Control and Systems Engineering Department, Faculty of Automatic Control and Computers, "Politehnica" University of Bucharest, 313th Independentei Street, 060042 Bucharest, Romania.
authors: Catalin
authors: 0000-0001-7159-8036
authors: C
authors: Buiu
authors: Anatomy, Animal Physiology and Biophysics Department, Faculty of Biology, University of Bucharest, 91-95th Independentei Street, 050095 Bucharest, Romania.
authors: Maria
authors: 0000-0003-3432-3302
authors: M
authors: Mernea
mesh_terms: D001927:Brain Diseases / Q000235:genetics* / Q000473:pathology; D002490:Central Nervous System / Q000737:chemistry / Q000473:pathology; D011508:Chondroitin Sulfate Proteoglycans / Q000737:chemistry* / Q000235:genetics / Q000648:ultrastructure; D018360:Crystallography, X-Ray; D005109:Extracellular Matrix / Q000235:genetics / Q000648:ultrastructure; D015894:Genome, Human; D006801:Humans; D009416:Nerve Regeneration / Q000235:genetics*; D013329:Structure-Activity Relationship
chemical_list: D011508:Chondroitin Sulfate Proteoglycans