title: Tubular breast cancer. A retrospective study.
abstract: BACKGROUND
  The well-characterized tubular-type of breast tumors is classified as low-risk breast cancer.
  
  
  METHODS
  We report on the results of a retrospective analysis on clinical and biological features of 248 tubular breast tumors including follow-up and treatment data from two German series of 21,065 breast cancer cases. The majority of tumors were stage I or stage II, ER- and PR-positive and c-erbB2-negative with a 5-year survival-rate of 96.3%. 51.3% of patients received hormonal treatment, 75.5% had post-operative radiotherapy and 11.8% were treated with a chemotherapeutical regimen.
  
  
  CONCLUSIONS
  Our retrospective analysis showed no treatment benefit for either anti-hormonal or chemotherapeutical regimens. Post-operative radiotherapy, however, improved the survival rate of patients with tubular carcinoma (log-rank=5, p=0.025). Our data suggest that post-operative radiotherapy is an important treatment to prolong survival for patients suffering from tubular breast cancer.
authors: Institute of Digital Medicine, Stuttgart, Germany Robert Bosch Hospital, Department of Clinical Pathology, Stuttgart, Germany.
authors: Peter
authors: P
authors: Fritz
authors: Pathology Hamburg-West, Hamburg, Germany.
authors: Klaus
authors: K
authors: Bendrat
authors: Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology and University of Tuebingen, Stuttgart, Germany maike.sonnenberg@ikp-stuttgart.de.
authors: Maike
authors: M
authors: Sonnenberg
authors: Robert Bosch Hospital, Department of Gynecology, Stuttgart, Germany.
authors: Christian
authors: C
authors: Trautmann
authors: Robert Bosch Hospital, Department of Clinical Pathology, Stuttgart, Germany.
authors: German
authors: G
authors: Ott
authors: Onkologischer Schwerpunkt Stuttgart e.V., Stuttgart, Germany.
authors: Else
authors: E
authors: Heidemann
authors: Onkologischer Schwerpunkt Stuttgart e.V., Stuttgart, Germany.
authors: Friedhelm
authors: F
authors: Brinkmann
authors: Onkologischer Schwerpunkt Stuttgart e.V., Stuttgart, Germany.
authors: Simone
authors: S
authors: Faisst
authors: Robert Bosch Hospital, Department of Gynecology, Stuttgart, Germany.
authors: Andreas
authors: A
authors: Gerteis
authors: Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology and University of Tuebingen, Stuttgart, Germany.
authors: Hiltrud
authors: H
authors: Brauch
authors: Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology and University of Tuebingen, Stuttgart, Germany Department of Clinical Pharmacology, University Hospital Tubingen, Tubingen, Germany.
authors: Matthias
authors: M
authors: Schwab
authors: Agaplesion Diakonieklinikum, Gynecology, Hamburg, Germany.
authors: Christoph
authors: C
authors: Lindner
authors: Mammazentrum Hamburg, Hamburg, Germany.
authors: Kay
authors: K
authors: Friedrichs
authors: Institute of Digital Medicine, Stuttgart, Germany.
authors: Mark Dominik
authors: MD
authors: Alscher
authors: University of Stuttgart, Institute of Stochastics and Applications, Stuttgart, Germany.
authors: Juergen
authors: J
authors: Dippon
authors: Pathology Hamburg-West, Hamburg, Germany.
authors: Axel
authors: A
authors: Niendorf
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology* / Q000628:therapy*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D012189:Retrospective Studies
keywords: Tubular breast cancer; breast cancer therapy; histological subtypes; survival