title: Multicentre observational cohort study of NSAIDs as risk factors for postoperative adverse events in gastrointestinal surgery.
abstract: BACKGROUND
  Non-steroidal anti-inflammatory drugs (NSAIDs) are recommended as postoperative analgesia by the Enhanced Recovery After Surgery Society. Recent studies have raised concerns that NSAID administration following colorectal anastomosis may be associated with increased risk of anastomotic leak. This multicentre study aims to determine NSAIDs' safety profile following gastrointestinal resection.
  
  
  METHODS
  This prospective, multicentre cohort study will be performed over a 2-week period utilising a collaborative methodology. Consecutive adults undergoing open or laparoscopic, elective or emergency gastrointestinal resection will be included. The primary end point will be the 30-day morbidity, assessed using the Clavien-Dindo classification. This study will be disseminated through medical student networks, with an anticipated recruitment of at least 900 patients. The study will be powered to detect a 10% increase in complication rates with NSAID use.
  
  
  BACKGROUND
  Following the Research Ethics Committee Chairperson's review, a formal waiver was received. This study will be registered as a clinical audit or service evaluation at each participating hospital. Dissemination will take place through previously described novel research collaborative networks.
authors: Norwich Academic Foundation Programme, Norwich, UK.
authors: Dmitri
authors: D
authors: Nepogodiev
authors: University of Leeds Medical School, Leeds, UK.
authors: Stephen J
authors: SJ
authors: Chapman
authors: Cardiff University Medical School, Cardiff, UK.
authors: James C D
authors: JC
authors: Glasbey
authors: University of Liverpool Medical School, Liverpool, UK.
authors: Michael
authors: M
authors: Kelly
authors: Imperial College London Medical School, London, UK.
authors: Chetan
authors: C
authors: Khatri
authors: University College London, London, UK.
authors: J Edward
authors: JE
authors: Fitzgerald
authors: West Midlands Deanery General Surgery Rotation, Birmingham, UK.
authors: Aneel
authors: A
authors: Bhangu
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D015331:Cohort Studies; D013505:Digestive System Surgical Procedures; D005260:Female; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000139:chemically induced* / Q000453:epidemiology*; D011446:Prospective Studies; D012107:Research Design; D012307:Risk Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal
keywords: Surgery