title: The protective effects of Schisandra chinensis fruit extract and its lignans against cardiovascular disease: a review of the molecular mechanisms.
abstract: Schisandra chinensis fruit extract (SCE) has traditionally been used as an oriental medicine for the treatment of various human diseases, including cardiovascular disease. Advances in scientific knowledge and analytical technologies provide opportunities for translational research involving S. chinensis; such research may contribute to future drug discovery. To date, emerging experimental evidence supports the therapeutic effects of the SCE or its bioactive lignan ingredients in cardiovascular disease, unraveling the mechanistic basis for their pharmacological actions. In the present review, we highlight SCE and its lignans as promising resources for the development of safe, effective, and multi-targeted agents against cardiovascular disease. Moreover, we offer novel insight into future challenges and perspective on S. chinensis research to future clinical investigations and healthcare strategies.
authors: Department of Physiology and Biomedical Sciences, Seoul National University College of Medicine, Seoul 110-799, Korea; Institute of Human-Environment Interface Biology, Seoul National University, Seoul 110-799, Korea. Electronic address: jnchun@gmail.com.
authors: Jung Nyeo
authors: JN
authors: Chun
authors: Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, Seoul, 152-742, Korea.
authors: Minsoo
authors: M
authors: Cho
authors: Department of Physiology and Biomedical Sciences, Seoul National University College of Medicine, Seoul 110-799, Korea; Institute of Human-Environment Interface Biology, Seoul National University, Seoul 110-799, Korea.
authors: Insuk
authors: I
authors: So
authors: Department of Physiology and Biomedical Sciences, Seoul National University College of Medicine, Seoul 110-799, Korea; Institute of Human-Environment Interface Biology, Seoul National University, Seoul 110-799, Korea. Electronic address: jhjeon2@snu.ac.kr.
authors: Ju-Hong
authors: JH
authors: Jeon
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D005355:Fibrosis / Q000188:drug therapy; D005638:Fruit; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D017705:Lignans / Q000494:pharmacology / Q000627:therapeutic use*; D018384:Oxidative Stress / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D032141:Schisandra; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D017705:Lignans; D010936:Plant Extracts
keywords: Cardiovascular disease; Lignans; Molecular mechanism; Schisandra chinensis; Signaling pathway