title: Medicinal plant cell suspension cultures: pharmaceutical applications and high-yielding strategies for the desired secondary metabolites.
abstract: The development of plant tissue (including organ and cell) cultures for the production of secondary metabolites has been underway for more than three decades. Plant cell cultures with the production of high-value secondary metabolites are promising potential alternative sources for the production of pharmaceutical agents of industrial importance. Medicinal plant cell suspension cultures (MPCSC), which are characterized with the feature of fermentation with plant cell totipotency, could be a promising alternative "chemical factory". However, low productivity becomes an inevitable obstacle limiting further commercialization of MPCSC and the application to large-scale production is still limited to a few processes. This review generalizes and analyzes the recent progress of this bioproduction platform for the provision of medicinal chemicals and outlines a range of trials taken or underway to increase product yields from MPCSC. The scale-up of MPCSC, which could lead to an unlimited supply of pharmaceuticals, including strategies to overcome and solution of the associated challenges, is discussed.
authors: a Department of Pharmacognosy, School of Pharmacy , Second Military Medical University , Shanghai , China .|b School of Life Science , East China Normal University , Shanghai , China .
authors: Wei
authors: W
authors: Yue
authors: a Department of Pharmacognosy, School of Pharmacy , Second Military Medical University , Shanghai , China .
authors: Qian-Liang
authors: QL
authors: Ming
authors: a Department of Pharmacognosy, School of Pharmacy , Second Military Medical University , Shanghai , China .
authors: Bing
authors: B
authors: Lin
authors: c Faculty of Science, School of Pharmacy and Biomolecular Sciences , Liverpool John Moores University , Byrom Street , Liverpool , UK , and.
authors: Khalid
authors: K
authors: Rahman
authors: a Department of Pharmacognosy, School of Pharmacy , Second Military Medical University , Shanghai , China .
authors: Cheng-Jian
authors: CJ
authors: Zheng
authors: a Department of Pharmacognosy, School of Pharmacy , Second Military Medical University , Shanghai , China .|d School of Forestry and Biotechnology , ZheJiang Agriculture & Forestry University , Lin'an , Hangzhou , China.
authors: Ting
authors: T
authors: Han
authors: a Department of Pharmacognosy, School of Pharmacy , Second Military Medical University , Shanghai , China .
authors: Lu-Ping
authors: LP
authors: Qin
mesh_terms: D001688:Biological Products / Q000032:analysis / Q000302:isolation & purification / Q000378:metabolism; D019149:Bioreactors; D018929:Cell Culture Techniques; D010946:Plants, Medicinal / Q000166:cytology / Q000378:metabolism
chemical_list: D001688:Biological Products
keywords: Application; medicinal plant; pharmaceutical; plant cell culture; secondary metabolite