title: microRNA regulation of lipoprotein metabolism.
abstract: OBJECTIVE
  The objective of this review article is to summarize the recent findings about the importance of microRNAs (miRNAs) in regulating lipoprotein metabolism. We highlight the recent findings that uncover the importance of miRNAs in controlling plasma LDL-cholesterol (LDL-C) levels.
  
  
  RESULTS
  In 2013, several studies reported a number of miRNAs that regulate plasma LDL-C levels, including miR-30c. In this review article, we discuss those miRNAs that modulate LDL-C levels and lipoprotein secretion. We also discuss the numerous studies that demonstrate the critical role of miRNAs in governing the many facets of HDL metabolism, such as the ATP transporters, ABCA1, and ABCG1, and the scavenger receptor, SRB1.
  
  
  CONCLUSIONS
  The understanding of how these miRNAs modulate lipoprotein metabolism promises to reveal new therapeutic targets to treat dyslipidemias and related cardiovascular disorders.
authors: aVascular Biology and Therapeutics Program bIntegrative Cell Signaling and Neurobiology of Metabolism Program, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut cDepartment of Medicine, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA.
authors: Leigh
authors: L
authors: Goedeke
authors: Juan F
authors: JF
authors: Aranda
authors: Carlos
authors: C
authors: Fernández-Hernando
mesh_terms: D064286:ATP Binding Cassette Transporter 1 / Q000235:genetics / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D008074:Lipoproteins / Q000378:metabolism*; D035683:MicroRNAs / Q000235:genetics*; D051122:Scavenger Receptors, Class B / Q000235:genetics / Q000378:metabolism
chemical_list: D064286:ATP Binding Cassette Transporter 1; D008074:Lipoproteins; D035683:MicroRNAs; C495124:SCARB1 protein, human; D051122:Scavenger Receptors, Class B; D002784:Cholesterol