title: Predicting the intestinal absorption potential of hits and leads.
abstract: Today's pharma environment requires rapid and reliable methods of screening drug leads for intestinal permeability potential in the early stages of drug discovery. Techniques using excised tissues, Caco-2 cells, artificial membranes, 'in silico' techniques and surface plasmon resonance (SPR)-based biosensors are critically examined in terms of their reliability, measurement criteria, throughput and utility in identifying potentially successful or unsuccessful drug molecules.:
authors: Biacore AB, Rapsgatan 7, S-75450 Uppsala, Sweden. Electronic address:markku.hamalainen@biacore.com.
authors: M D
authors: MD
authors: Hämäläinen
authors: Biacore AB, Rapsgatan 7, S-75450 Uppsala, Sweden.
authors: A
authors: A
authors: Frostell-Karlsson