title: Angiotensin Type-1 Receptor Blockade May Not Protect Kidney against Cisplatin-Induced Nephrotoxicity in Rats.
abstract: Background. Cisplatin (CDDP) is an anticancer drug, which is accompanied with major side effects including nephrotoxicity. We tested two doses of losartan (10 and 20 mg/kg/day) against nephrotoxicity in a rat model treated with daily administration of CDDP (2.5 mg/kg/day). Methods. Five groups of rats were examined. Groups 1 and 2 received losartan 10 and 20 mg/kg/day, i.p, for a period of 10 days. Group 3 received saline for 10 days, but from day 3 the animals received CDDP (2.5 mg/kg/day, i.p) for the next seven days. Groups 4 and 5 received treatment regimen the same as groups 1 and 2, but from day 3 they also received CDDP for the next seven days. At the end of the experiment, blood samples were obtained and the kidneys were removed to undergo pathological investigation and to obtain supernatant from homogenized tissue. Results. CDDP induced nephrotoxicity, but the serum levels of creatinine and blood urea nitrogen were not attenuated by losartan. The pathological findings confirmed that losartan did not have nephroprotective effect in this experimental model. Conclusion. According to the findings, losartan could not improve renal function impaired by toxicity induced by continuous doses of CDDP, and also it worsened the renal failure.
authors: Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan 81745, Iran ; Department of Biology, Falavarjan Branch, Islamic Azad University, Isfahan 84515, Iran.
authors: Roya
authors: R
authors: Rastghalam
authors: Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan 81745, Iran ; Department of Physiology, Isfahan University of Medical Sciences, Isfahan 81745, Iran ; Isfahan MN Institute of Basic and Applied Sciences Research, Isfahan 81546, Iran.
authors: Mehdi
authors: M
authors: Nematbakhsh
authors: Department of Biology, Falavarjan Branch, Islamic Azad University, Isfahan 84515, Iran.
authors: Mehrnoosh
authors: M
authors: Bahadorani
authors: Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan 81745, Iran.
authors: Fatemeh
authors: F
authors: Eshraghi-Jazi
authors: Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan 81745, Iran ; Department of Clinical Pathology, Isfahan University of Medical Sciences, Isfahan 81745, Iran.
authors: Ardeshir
authors: A
authors: Talebi
authors: Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan 81745, Iran.
authors: Maryam
authors: M
authors: Moeini
authors: Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan 81745, Iran ; Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan 81745, Iran.
authors: Farzaneh
authors: F
authors: Ashrafi
authors: Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan 81745, Iran.
authors: Soheila
authors: S
authors: Shirdavani