title: Viral regulators of complement activation: structure, function and evolution.
abstract: The complement system surveillance in the host is effective in controlling viral propagation. Consequently, to subvert this effector mechanism, viruses have developed a series of adaptations. One among these is encoding mimics of host regulators of complement activation (RCA) which help viruses to avoid being labeled as 'foreign' and protect them from complement-mediated neutralization and complement-enhanced antiviral adaptive immunity. In this review, we provide an overview on the structure, function and evolution of viral RCA proteins.
authors: National Centre for Cell Science, Pune University Campus, Ganeshkhind, Pune 411007, India.
authors: Hina
authors: H
authors: Ojha
authors: National Centre for Cell Science, Pune University Campus, Ganeshkhind, Pune 411007, India.
authors: Hemendra Singh
authors: HS
authors: Panwar
authors: Department of Bioengineering, University of California, Riverside, CA 92521, USA.
authors: Ronald D
authors: RD
authors: Gorham
authors: Department of Bioengineering, University of California, Riverside, CA 92521, USA. Electronic address: dmorikis@ucr.edu.
authors: Dimitrios
authors: D
authors: Morikis
authors: National Centre for Cell Science, Pune University Campus, Ganeshkhind, Pune 411007, India. Electronic address: arvindsahu@nccs.res.in.
authors: Arvind
authors: A
authors: Sahu
mesh_terms: D000818:Animals; D005075:Biological Evolution; D003167:Complement Activation / Q000276:immunology*; D003165:Complement System Proteins / Q000502:physiology*; D006801:Humans; D011485:Protein Binding; D014764:Viral Proteins / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism*
chemical_list: D014764:Viral Proteins; D003165:Complement System Proteins
keywords: Complement regulation; Herpesvirus; Immune evasion; Poxvirus; RCA; Viral evolution.