title: Bindings of ChREBP and SREBP1, and histone acetylation around the rat liver fatty acid synthase gene are associated with induction of the gene during the suckling-weaning transition.
abstract: It has been reported that the enzymic activity of fatty acid synthase (Fas) in rat liver increases during suckling-weaning transition. In this study, we investigated whether induction of the gene (Fasn) in the rat liver during the suckling-weaning transition is regulated by histone acetylation, and the nuclear transcription factors carbohydrate response element-binding protein (ChREBP) and sterol regulatory element-binding protein 1 (SREBP1). We observed that levels of Fas and Fasn increased during suckling-weaning transition. Binding levels of ChREBP and SREBP1 to upstream regions of Fasn increased during the suckling-weaning transition. Acetylation of histones H3 and H4 around Fasn increased during the transient period. Our results suggest that induction of liver Fasn during the suckling-weaning transition is closely associated with increased levels of ChREBP and SREBP1 binding, and acetylation of histones H3 and H4 around the gene.
authors: Department of Health and Nutritional Sciences, Faculty of Health Promotional Sciences, Hamamatsu University.
authors: Saho
authors: S
authors: Morishita
authors: Kazuki
authors: K
authors: Mochizuki
authors: Toshinao
authors: T
authors: Goda
mesh_terms: D000107:Acetylation; D000818:Animals; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000378:metabolism*; D064429:Fatty Acid Synthases / Q000235:genetics* / Q000378:metabolism; D015971:Gene Expression Regulation, Enzymologic; D006657:Histones / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D017207:Rats, Sprague-Dawley; D051780:Sterol Regulatory Element Binding Protein 1 / Q000378:metabolism*; D014886:Weaning
chemical_list: D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D006657:Histones; C442825:Mlxipl protein, rat; D051780:Sterol Regulatory Element Binding Protein 1; D064429:Fatty Acid Synthases