title: Mechanotransduction: tuning stem cells fate.
abstract: It is a general concern that the success of regenerative medicine-based applications is based on the ability to recapitulate the molecular events that allow stem cells to repair the damaged tissue/organ. To this end biomaterials are designed to display properties that, in a precise and physiological-like fashion, could drive stem cell fate both in vitro and in vivo. The rationale is that stem cells are highly sensitive to forces and that they may convert mechanical stimuli into a chemical response. In this review, we describe novelties on stem cells and biomaterials interactions with more focus on the implication of the mechanical stimulation named mechanotransduction.
authors: Department of Experimental Medicine and Biochemical Science, Section of Biochemistry and Molecular Biology, University of Perugia, Via del Giochetto, 06126 Perugia, Italy. francescodangelo@hotmail.it.
authors: Francesco
authors: F
authors: D'Angelo
authors: Department of Experimental Medicine and Biochemical Science, Section of Biochemistry and Molecular Biology, University of Perugia, Via del Giochetto, 06126 Perugia, Italy. robertotiribuzi@yahoo.it.
authors: Roberto
authors: R
authors: Tiribuzi
authors: Materials Engineering Centre, UdR INSTM, NIPLAB, University of Perugia, Strada di Pentima 4, 05100 Terni, Italy. ilaria.armentano@unipg.it.
authors: Ilaria
authors: I
authors: Armentano
authors: Materials Engineering Centre, UdR INSTM, NIPLAB, University of Perugia, Strada di Pentima 4, 05100 Terni, Italy. jkenny@unipg.it.
authors: Josè Maria
authors: JM
authors: Kenny
authors: Department of Experimental Medicine and Biochemical Science, Section of Biochemistry and Molecular Biology, University of Perugia, Via del Giochetto, 06126 Perugia, Italy. martinos@unipg.it.
authors: Sabata
authors: S
authors: Martino
authors: Department of Experimental Medicine and Biochemical Science, Section of Biochemistry and Molecular Biology, University of Perugia, Via del Giochetto, 06126 Perugia, Italy. orly@unipg.it.
authors: Aldo
authors: A
authors: Orlacchio