title: Increased serum cathepsin K in patients with coronary artery disease.
abstract: OBJECTIVE
  Cathepsin K is a potent collagenase implicated in human and animal atherosclerosis-based vascular remodeling. This study examined the hypothesis that serum CatK is associated with the prevalence of coronary artery disease (CAD).
  
  
  METHODS
  Between January 2011 and December 2012, 256 consecutive subjects were enrolled from among patients who underwent coronary angiography and percutaneous coronary intervention treatment. A total of 129 age-matched subjects served as controls.
  
  
  RESULTS
  The subjects' serum cathepsin K and high sensitive C-reactive protein (hs-CRP) and high-density lipoprotein cholesterol were measured. The patients with CAD had significantly higher serum cathepsin K levels compared to the controls (130.8±25.5 ng/mL vs. 86.9±25.5 ng/mL, p<0.001), and the patients with acute coronary syndrome had significantly higher serum cathepsin K levels compared to those with stable angina pectoris (137.1±26.9 ng/mL vs. 102.6±12.9 ng/mL, p<0.001). A linear regression analysis showed that overall, the cathepsin K levels were inversely correlated with the high-density lipoprotein levels (r=-0.29, p<0.01) and positively with hs-CRP levels (r=0.32, p<0.01). Multiple logistic regression analyses shows that cathepsin K levels were independent predictors of CAD (odds ratio, 1.76; 95% confidence interval, 1.12 to 1.56; p<0.01).
  
  
  CONCLUSIONS
  These data indicated that elevated levels of cathepsin K are closely associated with the presence of CAD and that circulating cathepsin K serves a useful biomarker for CAD.
authors: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin P.R., China.
authors: Xiang
authors: X
authors: Li
authors: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin P.R., China.
authors: Yuzi
authors: Y
authors: Li
authors: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin P.R., China.
authors: Jiyong
authors: J
authors: Jin
authors: Intervention Laboratory, Yanbian University Hospital, Yanji, Jilin P.R., China.
authors: Dehao
authors: D
authors: Jin
authors: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin P.R., China. lancui@ybu.edu.cn.
authors: Lan
authors: L
authors: Cui
authors: Central Laboratory, Yanbian University Hospital, Yanji, Jilin P.R., China.
authors: Xiangshan
authors: X
authors: Li
authors: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin P.R., China. ; Department of Anesthesiology, Yanbian University Hospital, Yanji, Jilin P.R., China.
authors: Yanna
authors: Y
authors: Rei
authors: Department of Physiology and Pathophysiology, Yanbian University Medical College, Yanji, Jilin P.R., China.
authors: Haiying
authors: H
authors: Jiang
authors: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin P.R., China.
authors: Guangxian
authors: G
authors: Zhao
authors: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin P.R., China.
authors: Guang
authors: G
authors: Yang
authors: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin P.R., China.
authors: Enbo
authors: E
authors: Zhu
authors: Department of Anesthesiology, Yanbian University Hospital, Yanji, Jilin P.R., China.
authors: Yongshan
authors: Y
authors: Nan
authors: Department of Cardiology, Yanbian University Hospital, Yanji, Jilin P.R., China. chengxw0908@163.com ; Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan. ; Department of Internal Medicine, Kyung Hee University Hospital, Seoul, Korea.
authors: Xianwu
authors: X
authors: Cheng
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D056657:Cathepsin K / Q000097:blood*; D003324:Coronary Artery Disease / Q000097:blood* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D056657:Cathepsin K
keywords: Cathepsin K; biomarker; coronary artery disease; high sensitive C-reactive protein; myocardial ischemia