title: Influence of DGKH variants on amygdala volume in patients with bipolar affective disorder and schizophrenia.
abstract: The diacylglycerol kinase eta (DGKH) gene, first identified in a genome-wide association study, is one of the few replicated risk genes of bipolar affective disorder (BD). Following initial positive studies, it not only was found to be associated with BD but also implicated in the etiology of other psychiatric disorders featuring affective symptoms, rendering DGKH a cross-disorder risk gene. However, the (patho-)physiological role of the encoded enzyme is still elusive. In the present study, we investigated primarily the influence of a risk haplotype on amygdala volume in patients suffering from schizophrenia or BD as well as healthy controls and four single nucleotide polymorphisms conveying risk. There was a significant association of the DGKH risk haplotype with increased amygdala volume in BD, but not in schizophrenia or healthy controls. These findings add to the notion of a role of DGKH in the pathogenesis of BD.
authors: Psychiatric Neurobiology and Bipolar Disorder Program, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Füchsleinstr. 15, 97080, Würzburg, Germany, Kittel_S@klinik.uni-wuerzburg.de.
authors: S
authors: S
authors: Kittel-Schneider
authors: T
authors: T
authors: Wobrock
authors: H
authors: H
authors: Scherk
authors: T
authors: T
authors: Schneider-Axmann
authors: S
authors: S
authors: Trost
authors: D
authors: D
authors: Zilles
authors: C
authors: C
authors: Wolf
authors: A
authors: A
authors: Schmitt
authors: B
authors: B
authors: Malchow
authors: A
authors: A
authors: Hasan
authors: M
authors: M
authors: Backens
authors: W
authors: W
authors: Reith
authors: P
authors: P
authors: Falkai
authors: O
authors: O
authors: Gruber
authors: A
authors: A
authors: Reif
mesh_terms: D000328:Adult; D000679:Amygdala / Q000473:pathology*; D001714:Bipolar Disorder / Q000235:genetics* / Q000473:pathology*; D004252:DNA Mutational Analysis; D019852:Diacylglycerol Kinase / Q000235:genetics*; D005260:Female; D007839:Functional Laterality; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000235:genetics* / Q000473:pathology*; D018709:Statistics, Nonparametric
chemical_list: C526463:DGKZ protein, human; D019852:Diacylglycerol Kinase