title: Autobiographical narratives relate to Alzheimer's disease biomarkers in older adults.
abstract: BACKGROUND
  Autobiographical memory (ABM), personal semantic memory (PSM), and autonoetic consciousness are affected in individuals with mild cognitive impairment (MCI) but their relationship with Alzheimer's disease (AD) biomarkers are unclear.
  
  
  METHODS
  Forty-five participants (healthy controls (HC) = 31, MCI = 14) completed the Episodic ABM Interview and a battery of memory tests. Thirty-one (HC = 22, MCI = 9) underwent β-amyloid positron emission tomography (PET) and magnetic resonance (MR) imaging. Fourteen participants (HC = 9, MCI = 5) underwent one imaging modality.
  
  
  RESULTS
  Unlike PSM, ABM differentiated between diagnostic categories but did not relate to AD biomarkers. Personal semantic memory was related to neocortical β-amyloid burden after adjusting for age and apolipoprotein E (APOE) ɛ4. Autonoetic consciousness was not associated with AD biomarkers, and was not impaired in MCI.
  
  
  CONCLUSIONS
  Autobiographical memory was impaired in MCI participants but was not related to neocortical amyloid burden, suggesting that personal memory systems are impacted by differing disease mechanisms, rather than being uniformly underpinned by β-amyloid. Episodic and semantic ABM impairment represent an important AD prodrome.
authors: Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Victoria, Australia.|The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia.
authors: Rachel F
authors: RF
authors: Buckley
authors: Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Victoria, Australia.|The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia.
authors: Michael M
authors: MM
authors: Saling
authors: Neuroscience Research Australia, Sydney, New South Wales, Australia.|School of Psychology, the University of New South Wales, Kensington, Sydney, New South Wales, Australia.
authors: Muireann
authors: M
authors: Irish
authors: National Aging Research Institute, Melbourne, Victoria, Australia.|The Academic Unit for Psychiatry of Old Age, St. Vincent's Hospital, Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia.
authors: David
authors: D
authors: Ames
authors: Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Australia.|The Department of Medicine, Austin Health, University of Melbourne, Melbourne, Victoria, Australia.
authors: Christopher C
authors: CC
authors: Rowe
authors: Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Australia.|The Department of Medicine, Austin Health, University of Melbourne, Melbourne, Victoria, Australia.
authors: Victor L
authors: VL
authors: Villemagne
authors: The Academic Unit for Psychiatry of Old Age, St. Vincent's Hospital, Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia.|School of Psychiatry and Clinical Neurosciences and West Australian Centre for Health & Ageing, University of Western Australia, Crawley, Australia.
authors: Nicola T
authors: NT
authors: Lautenschlager
authors: The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia.|Cogstate Ltd, Melbourne, Victoria, Australia.
authors: Paul
authors: P
authors: Maruff
authors: Commonwealth Scientific Industrial Research Organization, Melbourne, Victoria, Australia.
authors: S Lance
authors: SL
authors: Macaulay
authors: Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical Sciences, Edith Cowan University, Perth, Western Australia, Australia.|Sir James McCusker Alzheimer's Disease Research Unit (Hollywood Private Hospital), Perth, Western Australia, Australia.|School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Western Australia, Australia.
authors: Ralph N
authors: RN
authors: Martins
authors: National Aging Research Institute, Melbourne, Victoria, Australia.
authors: Cassandra
authors: C
authors: Szoeke
authors: The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia.
authors: Colin L
authors: CL
authors: Masters
authors: Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical Sciences, Edith Cowan University, Perth, Western Australia, Australia.|Sir James McCusker Alzheimer's Disease Research Unit (Hollywood Private Hospital), Perth, Western Australia, Australia.
authors: Stephanie R
authors: SR
authors: Rainey-Smith
authors: The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia.
authors: Alan
authors: A
authors: Rembach
authors: ARC Centre of Excellence in Cognition and its Disorders, Macquarie University, Sydney, New South Wales, Australia.
authors: Greg
authors: G
authors: Savage
authors: The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia.|The Academic Unit for Psychiatry of Old Age, St. Vincent's Hospital, Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia.
authors: Kathryn A
authors: KA
authors: Ellis
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000523:psychology; D016229:Amyloid beta-Peptides / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D001923:Brain Chemistry; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory; D008569:Memory Disorders / Q000175:diagnosis / Q000523:psychology; D061212:Memory, Episodic; D059906:Neuroimaging; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers