title: A single pathway targets several health challenges of the elderly.
abstract: New avenues to modulate the autophagy-lysosomal route of protein clearance have the potential to help treat several disease states to which the elderly are particularly vulnerable. Two recent papers identified distinct ways to tap into the lysosomal degradation pathway of autophagy to reduce age-related protein accumulation events. Shoji-Kawata et al. (Nature 2013;494:201-206) describe a new autophagy-inducing peptide, Tat-Beclin 1, that enhances the clearance of polyglutamine aggregates related to Huntington's disease and, interestingly, suppresses viral and bacterial infections. Savolainen et al. (Neurobiol Dis 2014;68:1-15) describe a prolyl oligopeptidase inhibitor that reduces α-synuclein species related to Parkinson's disease and other α-synucleinopathies, and this inhibitor caused a concomitant increase in autophagic activation markers. Previous studies have also linked the autophagy-lysosomal pathway to the protective clearing of the Aβ peptides of Alzheimer's disease and tau species of tauopathies. Enhancing autophagy-lysosomal efficiency may provide a therapeutic avenue for diverse types of proteinopathies, including the most common neurodegenerative disorders of the elderly.
authors: Biotechnology Research and Training Center, William C. Friday Laboratory, University of North Carolina-Pembroke , Pembroke, North Carolina.
authors: Ben A
authors: BA
authors: Bahr
mesh_terms: D000818:Animals; D051017:Apoptosis Regulatory Proteins / Q000737:chemistry* / Q000627:therapeutic use*; D001343:Autophagy / Q000187:drug effects*; D001927:Brain Diseases / Q000235:genetics*; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry* / Q000627:therapeutic use*; D010446:Peptide Fragments / Q000737:chemistry* / Q000494:pharmacology*; D011392:Proline / Q000031:analogs & derivatives*; D012697:Serine Endopeptidases / Q000378:metabolism*; D015842:Serine Proteinase Inhibitors / Q000627:therapeutic use*; D051844:alpha-Synuclein / Q000378:metabolism*
chemical_list: D051017:Apoptosis Regulatory Proteins; D008565:Membrane Proteins; D010446:Peptide Fragments; D015842:Serine Proteinase Inhibitors; D051844:alpha-Synuclein; D011392:Proline; D012697:Serine Endopeptidases