title: Cancer stem-like cells: the dark knights of clinical hematology and oncology.
abstract: According to recent epidemiological studies, malignant diseases represent the second cause of mortality worldwide and metastasis is the main cause of morbidity and mortality in most cancers. Even if the concept of "cancer stem cells" (CSCs) was anticipated by the genius of Rudolph Virchow, the father of modern pathology, more than 150 years ago, it is only in last few years that that scientists have begun to develop strategies aimed at inhibiting CSCs at a molecular level, the only way cancer can truly be attacked, by crossing the border between histology and molecular biology. The current concise review aims at emphasizing the main characteristics of tumor initiating cells, bridging the basic science to clinical hematology and oncology.
authors: Department of Hematology, Ion Chiricuta Cancer Center, Cluj-Napoca, Romania.
authors: Ioana
authors: I
authors: Frinc
authors: Mihai-Stefan
authors: MS
authors: Muresan
authors: Florin
authors: F
authors: Zaharie
authors: Ljubomir
authors: L
authors: Petrov
authors: Alexandra
authors: A
authors: Irimie
authors: Cristian
authors: C
authors: Berce
authors: Ioana
authors: I
authors: Berindan-Neagoe
authors: Ciprian
authors: C
authors: Tomuleasa
mesh_terms: D006405:Hematology; D006801:Humans; D008495:Medical Oncology; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000473:pathology / Q000503:physiopathology; D014411:Neoplastic Stem Cells / Q000502:physiology*; D055153:Stem Cell Niche / Q000502:physiology