title: Primitive neuroectodermal tumor originating in the vulva: A case report.
abstract: Primitive neuroectodermal tumors (PNETs) exhibit chromosomal translocations in common with those of Ewing's sarcoma. They usually originate in bone or soft tissue but rarely arise in the vulva. The current case report presents a case of PNET originating in the vulva in a 60-year-old female, who previously underwent enucleation of a vulvar tumor in another hospital. The pathologist suspected a histopathological diagnosis of PNET, and simple vulvectomy and resection of the inguinal lymph nodes were performed. An ~3 cm mass recurred in the right side of the vulva four years following the initial surgery and the tumor was excised. The tumor comprised small, round-to-oval nuclei and stained positively for MIC-2, synaptophysin, neuron-specific enolase and neurofilament antibodies. To date, the patient remains alive and with no evidence of disease four years following multidisciplinary treatment, despite PNETs usually exhibiting a poor prognosis. This is due to the small tumor size and the absence of distant metastasis.
authors: Department of Obstetrics and Gynecology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.
authors: Makiko
authors: M
authors: Matsuda
authors: Department of Obstetrics and Gynecology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.
authors: Tomoyuki
authors: T
authors: Ichimura
authors: Department of Obstetrics and Gynecology, Osaka City Sumiyoshi Hospital, Osaka 559-0012, Japan.
authors: Mari
authors: M
authors: Kasai
authors: Department of Obstetrics and Gynecology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.
authors: Makoto
authors: M
authors: Murakami
authors: Department of Orthopedic Surgery, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.
authors: Manabu
authors: M
authors: Hoshi
authors: Department of Obstetrics and Gynecology, Osaka City General Hospital, Osaka 534-0021, Japan.
authors: Naoki
authors: N
authors: Kawamura
authors: Department of Obstetrics and Gynecology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.
authors: Toshiyuki
authors: T
authors: Sumi
keywords: MIC-2; primitive neuroectodermal tumor; vulva