title: Comparative pharmacokinetics of naringin in rat after oral administration of chaihu-shu-gan-san aqueous extract and naringin alone.
abstract: Chaihu-Shu-Gan-San (CSGS), a traditional Chinese medicine (TCM) formula containing seven herbal medicines, has been used in the clinical treatment of gastritis, peptic ulcer, irritable bowel syndrome and depression in China. In order to explore the interaction between naringin and other constituents in CSGS, the pharmacokinetic difference of naringin in rats after oral administration of CSGS aqueous extract and naringin alone was investigated. The pharmacokinetic parameters of naringin in rats were achieved by quantification of its aglycone, naringenin by LC-MS/MS method. The double peaks phenomenon was observed in both serum profiles of rats after orally administered CSGS aqueous extract and naringin alone. However, the T1/2b was significantly decreased in rats given CSGS aqueous extract compared with naringin alone, and the mean residence time (MRT) and the area under the serum concentration-time curve (AUC0-τ) were higher than those of naringin, which indicated that naringin in CSGS had higher bioavailability, longer term efficacy and somewhat faster metabolism and excretion than those of naringin. The results suggested that certain ingredients co-exist in CSGS could influence pharmacokinetic behavior of naringin. This also provides a reference for human studies.
authors: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China. lishuqibrezz@163.com.
authors: Shu-Qi
authors: SQ
authors: Li
authors: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China. book_000@163.com.
authors: Shu
authors: S
authors: Dong
authors: Guangxi Medical University, Nanning 530021, China. suzhiheng1981@126.com.
authors: Zhi-Heng
authors: ZH
authors: Su
authors: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China. hwzhang@implad.ac.cn.
authors: Hong-Wu
authors: HW
authors: Zhang
authors: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China. tinghai10142000@yahoo.com.cn.
authors: Jing-Bo
authors: JB
authors: Peng
authors: College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China. yucy@mail.buct.edu.cn.
authors: Chang-Yuan
authors: CY
authors: Yu
authors: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China. zmzou@implad.ac.cn.
authors: Zhong-Mei
authors: ZM
authors: Zou