title: Interleukin-6 gene polymorphisms, dietary fat intake, obesity and serum lipid concentrations in black and white South African women.
abstract: This study investigated interactions between dietary fat intake and IL-6 polymorphisms on obesity and serum lipids in black and white South African (SA) women. Normal-weight and obese, black and white women underwent measurements of body composition, serum lipids and dietary fat intake, and were genotyped for the IL-6 -174 G>C, IVS3 +281 G>T and IVS4 +869 A>G polymorphisms. In black women the IVS4 +869 G allele was associated with greater adiposity, and with increasing dietary fat intake adiposity increased in the IVS3 +281 GT+GG and IVS4 +869 AA or AG genotypes. In white women, with increasing omega-3 (n-3) intake and decreasing n-6:n-3 ratio, body mass index (BMI) decreased in those with the -174 C allele, IVS3 +281 T allele and IVS4 +869 AG genotype. In the white women, those with the IVS3 +281 T allele had lower triglycerides. Further, with increasing n-3 polyunsaturated fatty acid (PUFA); triglyceride and total cholesterol:high-density lipoprotein cholesterol (T-C:HDL-C) ratio decreased in those with the -174 C allele. In black women, with increasing total fat intake, triglycerides and T-C:HDL-C ratio increased in those with the IVS4 +869 G allele. This study is the first to show that dietary fat intake modulates the relationship between the IL-6 -174 G>C, IVS3 +281 G>T and IVS4 +869 A>G polymorphisms on obesity and serum lipids in black and white SA women.
authors: UCT/MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town 7505, South Africa. yael.joffe@gmail.com.
authors: Yael T
authors: YT
authors: Joffe
authors: UCT/MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town 7505, South Africa. lize@lizestats.co.za.
authors: Lize
authors: L
authors: van der Merwe
authors: UCT/MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town 7505, South Africa. juliet.evans@westerncape.gov.za.
authors: Juliet
authors: J
authors: Evans
authors: UCT/MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town 7505, South Africa. malcolm.collins@uct.ac.za.
authors: Malcolm
authors: M
authors: Collins
authors: UCT/MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town 7505, South Africa. vicki.lambert@uct.ac.za.
authors: Estelle V
authors: EV
authors: Lambert
authors: UCT/MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town 7505, South Africa. alison.september@uct.ac.za.
authors: Alison V
authors: AV
authors: September
authors: UCT/MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town 7505, South Africa. julia.goedecke@mrc.ac.za.
authors: Julia H
authors: JH
authors: Goedecke
mesh_terms: D000328:Adult; D000483:Alleles; D044383:Black People; D001823:Body Composition; D015992:Body Mass Index; D004041:Dietary Fats / Q000008:administration & dosage*; D002149:Energy Intake; D005260:Female; D005838:Genotype; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics / Q000378:metabolism*; D008055:Lipids / Q000097:blood*; D009765:Obesity / Q000453:epidemiology*; D011110:Polymorphism, Genetic; D013019:South Africa; D044465:White People
chemical_list: D004041:Dietary Fats; D015850:Interleukin-6; D008055:Lipids