title: Prevalence of perfusion defects detected by stress 99mtechnetium sestamibi myocardial perfusion single-photon emission computed tomography in asymptomatic patients with breast cancer.
abstract: OBJECTIVE
  The aim of the present study was to investigate myocardial perfusion in relation to disease history and laboratory parameters of atherosclerosis risk in asymptomatic patients with breast carcinoma.
  
  
  METHODS
  One-hundred and eighty-one patients with breast carcinoma were studied. Myocardial perfusion was assessed using single-photon emission computed tomography (SPECT) with 99mtechnetium sestamibi.
  
  
  RESULTS
  Perfusion defects were detected in 12 patients (7%). Higher body-mass index, increased concentrations of D-dimers, C-reactive protein, fibrinogen, glucose, triglycerides, and urinary albumin, a history of hypertension and of radiotherapy to the left chest wall were all associated with increased risk of perfusion defects. In a multivariate stepwise selection logistic regression model, body mass index, albuminuria and radiotherapy to the left hemithorax were significantly associated with the presence of perfusion defects.
  
  
  CONCLUSIONS
  In addition to other factors, treatment history may be associated with the presence of perfusion defects in patients with breast cancer.
authors: Department of Oncology, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic Department of Oncology and Radiotherapy, Charles University Medical School and Teaching Hospital, Hradec Králové, Czech Republic; Fourth Department of Medicine, Charles University Medical School and Teaching Hospital, Hradec Králové, Czech Republic;
authors: Bohuslav
authors: B
authors: Melichar
authors: Department of Nuclear Medicine, Charles University Medical School and Teaching Hospital, Hradec Králové, Czech Republic;
authors: Jiří
authors: J
authors: Doležal
authors: Department of Oncology, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic.
authors: Vlastislav
authors: V
authors: Srámek
authors: Department of Oncology, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic.
authors: Hana
authors: H
authors: Kalábová
authors: Third Department of Medicine, Charles University Medical School and Teaching Hospital, Hradec Králové, Czech Republic; Department of Analytical Chemistry, Charles University School of Pharmacy, Hradec Králové, Czech Republic.
authors: Lenka Kujovská
authors: LK
authors: Krčmová
authors: Third Department of Medicine, Charles University Medical School and Teaching Hospital, Hradec Králové, Czech Republic;
authors: Radomír
authors: R
authors: Hyšpler
authors: Department of Oncology, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic.
authors: Hana
authors: H
authors: Studentová
authors: Department of Oncology and Radiotherapy, Charles University Medical School and Teaching Hospital, Hradec Králové, Czech Republic;
authors: Milan
authors: M
authors: Vošmik
authors: Fourth Department of Medicine, Charles University Medical School and Teaching Hospital, Hradec Králové, Czech Republic;
authors: Miroslav
authors: M
authors: Pecka
authors: International Clinical Research Center-Department of Clinical Development and Technology Transfer, St. Anne's University Hospital, Brno, Czech Republic.
authors: Adam
authors: A
authors: Svobodník
authors: International Clinical Research Center-Department of Clinical Development and Technology Transfer, St. Anne's University Hospital, Brno, Czech Republic.
authors: Ladislav
authors: L
authors: Pecen
authors: Department of Oncology, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic dolezelm@email.cz.
authors: Martin
authors: M
authors: Doležel
authors: Department of Nuclear Medicine, Charles University Medical School and Teaching Hospital, Hradec Králové, Czech Republic;
authors: Dagmar
authors: D
authors: Solichová
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
chemical_list: D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi
keywords: Atherosclerosis; breast cancer; single-photon emission computed tomography