title: Kif7 keeps cilia tips in shape.
abstract: The kinesin-4 motor protein Kif7 regulates Hedgehog signalling at cilia in mammals by controlling the activity of Gli transcription factors. Kif7 is now found to inhibit microtubule growth to restrict and coordinate the length of axonemal microtubules at the ciliary tip. Such Kif7-mediated organization of the ciliary tip compartment regulates Gli activity and is proposed to be required for correct Hedgehog signalling.
authors: Department of Biology, University of Copenhagen, Universitetsparken 13, 2100 Copenhagen OE, Denmark.
authors: Lotte B
authors: LB
authors: Pedersen
authors: Department of Biology, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.
authors: Anna
authors: A
authors: Akhmanova
mesh_terms: D000818:Animals; D002923:Cilia / Q000378:metabolism*; D053823:Hedgehog Proteins / Q000378:metabolism*; D006801:Humans; D016547:Kinesins / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D053823:Hedgehog Proteins; C543639:Kif7 protein, mouse; D016547:Kinesins