title: Nicotine enhances the expression of a sucrose or cocaine conditioned place preference in adult male rats.
abstract: Nicotine has been shown to enhance the motivational properties of non-nicotine stimuli. This reinforcement-enhancing property of nicotine has the potential to promote the use of other illicit substances as well as maladaptive patterns of food intake. Therefore, the current study aimed to examine whether nicotine enhances preference for contexts paired with cocaine or sucrose utilizing a place conditioning procedure. Separate groups of adult male rats were administered sucrose or cocaine in one of two compartments of a standard CPP chamber on four consecutive days. Preference was then assessed following no injection, a single subcutaneous (s.c.) injection of nicotine, and a s.c. saline injection. The animals preferred the chamber paired with either sucrose or cocaine, as evident from an increased time spent in the paired chamber compared to baseline. Nicotine further increased the time spent in the sucrose- or cocaine-paired chamber, consistent with a reinforcement-enhancement effect. Previous results demonstrate an interaction between nicotine and intake of other drugs or food. The present findings provide an additional mechanism that may underlie these effects and which may have implications for drug dependence and obesity.
authors: Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA. Electronic address: deanne@pitt.edu.
authors: Deanne M
authors: DM
authors: Buffalari
authors: Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA.
authors: Nana Yaa A
authors: NY
authors: Marfo
authors: Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA.
authors: Tracy T
authors: TT
authors: Smith
authors: Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA.
authors: Melissa E
authors: ME
authors: Levin
authors: Department of Psychology, Mercyhurst University, Erie, PA 16546, USA.
authors: Matthew T
authors: MT
authors: Weaver
authors: Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15260, USA.
authors: Edda
authors: E
authors: Thiels
authors: Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA.
authors: Alan F
authors: AF
authors: Sved
authors: Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA.
authors: Eric C
authors: EC
authors: Donny
mesh_terms: D000818:Animals; D003042:Cocaine / Q000008:administration & dosage*; D003214:Conditioning, Classical; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013395:Sucrose / Q000008:administration & dosage*
chemical_list: D013395:Sucrose; D009538:Nicotine; D003042:Cocaine
keywords: Cocaine; Conditioned place preference; Enhancement; Nicotine; Reinforcement; Sucrose