title: Modeling the phenotypic architecture of autism symptoms from time of diagnosis to age 6.
abstract: The latent class structure of autism symptoms from the time of diagnosis to age 6 years was examined in a sample of 280 children with autism spectrum disorder. Factor mixture modeling was performed on 26 algorithm items from the Autism Diagnostic Interview - Revised at diagnosis (Time 1) and again at age 6 (Time 2). At Time 1, a "2-factor/3-class" model provided the best fit to the data. At Time 2, a "2-factor/2-class" model provided the best fit to the data. Longitudinal (repeated measures) analysis of variance showed that the "2-factor/3-class" model derived at the time of diagnosis allows for the identification of a subgroup of children (9 % of sample) who exhibit notable reduction in symptom severity.
authors: Offord Centre for Child Studies, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L8, Canada, georgis@mcmaster.ca.
authors: Stelios
authors: S
authors: Georgiades
authors: Michael
authors: M
authors: Boyle
authors: Peter
authors: P
authors: Szatmari
authors: Steven
authors: S
authors: Hanna
authors: Eric
authors: E
authors: Duku
authors: Lonnie
authors: L
authors: Zwaigenbaum
authors: Susan
authors: S
authors: Bryson
authors: Eric
authors: E
authors: Fombonne
authors: Joanne
authors: J
authors: Volden
authors: Pat
authors: P
authors: Mirenda
authors: Isabel
authors: I
authors: Smith
authors: Wendy
authors: W
authors: Roberts
authors: Tracy
authors: T
authors: Vaillancourt
authors: Charlotte
authors: C
authors: Waddell
authors: Teresa
authors: T
authors: Bennett
authors: Mayada
authors: M
authors: Elsabbagh
authors: Ann
authors: A
authors: Thompson
mesh_terms: D000367:Age Factors; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000145:classification* / Q000175:diagnosis* / Q000523:psychology; D002675:Child, Preschool; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D010641:Phenotype