title: The ECM-cell interaction of cartilage extracellular matrix on chondrocytes.
abstract: Cartilage extracellular matrix (ECM) is composed primarily of the network type II collagen (COLII) and an interlocking mesh of fibrous proteins and proteoglycans (PGs), hyaluronic acid (HA), and chondroitin sulfate (CS). Articular cartilage ECM plays a crucial role in regulating chondrocyte metabolism and functions, such as organized cytoskeleton through integrin-mediated signaling via cell-matrix interaction. Cell signaling through integrins regulates several chondrocyte functions, including differentiation, metabolism, matrix remodeling, responses to mechanical stimulation, and cell survival. The major signaling pathways that regulate chondrogenesis have been identified as wnt signal, nitric oxide (NO) signal, protein kinase C (PKC), and retinoic acid (RA) signal. Integrins are a large family of molecules that are central regulators in multicellular biology. They orchestrate cell-cell and cell-matrix adhesive interactions from embryonic development to mature tissue function. In this review, we emphasize the signaling molecule effect and the biomechanics effect of cartilage ECM on chondrogenesis.
authors: Institute of Orthopedics, Chinese PLA General Hospital, Beijing 100853, China.
authors: Yue
authors: 0000-0001-9287-4730
authors: Y
authors: Gao
authors: Institute of Orthopedics, Chinese PLA General Hospital, Beijing 100853, China.
authors: Shuyun
authors: S
authors: Liu
authors: Institute of Orthopedics, Chinese PLA General Hospital, Beijing 100853, China.
authors: Jingxiang
authors: J
authors: Huang
authors: Institute of Orthopedics, Chinese PLA General Hospital, Beijing 100853, China.
authors: Weimin
authors: W
authors: Guo
authors: Institute of Orthopedics, Chinese PLA General Hospital, Beijing 100853, China.
authors: Jifeng
authors: J
authors: Chen
authors: Institute of Orthopedics, Chinese PLA General Hospital, Beijing 100853, China.
authors: Li
authors: L
authors: Zhang
authors: Institute of Orthopedics, Chinese PLA General Hospital, Beijing 100853, China.
authors: Bin
authors: B
authors: Zhao
authors: Institute of Orthopedics, Chinese PLA General Hospital, Beijing 100853, China.
authors: Jiang
authors: J
authors: Peng
authors: Institute of Orthopedics, Chinese PLA General Hospital, Beijing 100853, China.
authors: Aiyuan
authors: A
authors: Wang
authors: Institute of Orthopedics, Chinese PLA General Hospital, Beijing 100853, China.
authors: Yu
authors: Y
authors: Wang
authors: Institute of Orthopedics, Chinese PLA General Hospital, Beijing 100853, China.
authors: Wenjing
authors: W
authors: Xu
authors: Institute of Orthopedics, Chinese PLA General Hospital, Beijing 100853, China.
authors: Shibi
authors: S
authors: Lu
authors: Institute of Orthopedics, Chinese PLA General Hospital, Beijing 100853, China.
authors: Mei
authors: M
authors: Yuan
authors: Institute of Orthopedics, Chinese PLA General Hospital, Beijing 100853, China.
authors: Quanyi
authors: Q
authors: Guo
mesh_terms: D002356:Cartilage / Q000166:cytology / Q000378:metabolism; D002448:Cell Adhesion / Q000235:genetics; D002450:Cell Communication / Q000235:genetics*; D002454:Cell Differentiation / Q000235:genetics*; D019902:Chondrocytes / Q000166:cytology*; D020219:Chondrogenesis / Q000187:drug effects / Q000235:genetics; D005109:Extracellular Matrix / Q000378:metabolism*; D006801:Humans; D016023:Integrins / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics; D014212:Tretinoin / Q000494:pharmacology
chemical_list: D016023:Integrins; D014212:Tretinoin