title: Treatment of inflammatory myofibroblastic tumor of the subglottis with KTP laser: a case report.
abstract: Although inflammatory myofibroblastic tumors (IMTs) are seen in the lower respiratory tract in the pediatric population, few cases occurring in the larynx have been reported in the literature. Treatment of choice is complete surgical excision because of risk of recurrence. We describe a case of pediatric subglottic IMT presenting with progressive hoarseness and symptoms of persistent reactive airway treated with potassium titanyl phosphate laser. We also enumerate the number of pediatric cases of IMT that occur in the larynx and subglottis compared with those which occur in the upper respiratory tract, specifically the trachea and bronchi. To the best of our knowledge, this is the first reported case of respiratory tract IMT excision using a potassium titanyl phosphate laser and the second reported case of a pediatric laryngeal IMT showing anaplastic lymphoma kinase-1 immunoreactivity.
authors: Department of Otolaryngology, Detroit Medical Center, Children's Hospital of Michigan, Detroit, Michigan; Department of Surgical Services, Michigan State University, Lansing, Michigan. Electronic address: mkieu@dmc.org.
authors: Monica Q
authors: MQ
authors: Kieu
authors: Department of Otolaryngology, Detroit Medical Center, Children's Hospital of Michigan, Detroit, Michigan; Department of Surgical Services, Michigan State University, Lansing, Michigan.
authors: Prasad J
authors: PJ
authors: Thottam
authors: Department of Otolaryngology, Detroit Medical Center, Children's Hospital of Michigan, Detroit, Michigan; Department of Surgical Services, Michigan State University, Lansing, Michigan.
authors: Victor
authors: V
authors: DaCosta
authors: Department of Pathology, Detroit Medical Center, Children's Hospital of Michigan, Detroit, Michigan.
authors: Laura
authors: L
authors: Gonzalez-Krellwitz
authors: Department of Pathology, Detroit Medical Center, Children's Hospital of Michigan, Detroit, Michigan.
authors: Janet M
authors: JM
authors: Poulik
authors: Department of Otolaryngology, Detroit Medical Center, Children's Hospital of Michigan, Detroit, Michigan; Department of Surgical Services, Michigan State University, Lansing, Michigan.
authors: David N
authors: DN
authors: Madgy
mesh_terms: D000077548:Anaplastic Lymphoma Kinase; D001706:Biopsy; D002675:Child, Preschool; D005260:Female; D006104:Granuloma, Plasma Cell / Q000150:complications / Q000175:diagnosis / Q000201:enzymology / Q000601:surgery*; D006685:Hoarseness / Q000209:etiology; D006801:Humans; D007150:Immunohistochemistry; D007818:Laryngeal Diseases / Q000150:complications / Q000175:diagnosis / Q000201:enzymology / Q000601:surgery*; D007828:Laryngoscopy; D007829:Laryngostenosis / Q000209:etiology; D053685:Laser Therapy / Q000295:instrumentation*; D053844:Lasers, Solid-State; D020794:Receptor Protein-Tyrosine Kinases / Q000032:analysis; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases
keywords: Inflammatory fibrosarcoma; Inflammatory myofibroblastic tumor; Inflammatory pseudotumors; KTP laser; Laryngotracheal stenosis; Plasma cell granulomas; Potassium titanyl phosphate laser; Stridor; Subglottic stenosis