title: Association between ephrin-A1 mRNA expression and poor prognosis after hepatectomy to treat hepatocellular carcinoma.
abstract: Hypoxia regulates the expression of genes that promote tumor growth, angiogenesis and invasion. We previously studied hypoxic tumor cells in vitro and from hepatic metastases of colorectal cancer and determined several potential prognostic factors for hepatocellular carcinoma (HCC). In this study, we evaluated the prognostic impact of the expression of ephrin-A1 (EFNA1) and its receptor, EPHA2, in patients with HCC after curative resection. Samples from a total of 139 HCC patients were analyzed by either microarray alone (n=86) or by microarray and quantitative PCR (n=53). There was no correlation between EFNA1 expression and clinicopathological factors. EPHA2 expression was not significantly correlated with any clinicopathological factors, except for microscopic portal invasion. EFNA1 was an independent prognostic factor for HCC (p=0.0277). These findings suggest that EFNA1 expression may be a useful marker for predicting high risk of recurrence in patients who have undergone curative resection for HCC.
authors: Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
authors: Hiroshi
authors: H
authors: Wada
authors: Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
authors: Hirofumi
authors: H
authors: Yamamoto
authors: Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
authors: Chiwan
authors: C
authors: Kim
authors: Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
authors: Mamoru
authors: M
authors: Uemura
authors: Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
authors: Hirofumi
authors: H
authors: Akita
authors: Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
authors: Yoshito
authors: Y
authors: Tomimaru
authors: Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
authors: Naoki
authors: N
authors: Hama
authors: Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
authors: Koichi
authors: K
authors: Kawamoto
authors: Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
authors: Shogo
authors: S
authors: Kobayashi
authors: Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
authors: Hidetoshi
authors: H
authors: Eguchi
authors: Division of Health Sciences, Graduate School of Medicine, Osaka University, Osaka, Japan.
authors: Koji
authors: K
authors: Umeshita
authors: Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
authors: Yuichiro
authors: Y
authors: Doki
authors: Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
authors: Masaki
authors: M
authors: Mori
authors: Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
authors: Hiroaki
authors: H
authors: Nagano
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D045744:Cell Line, Tumor; D036382:Ephrin-A1 / Q000235:genetics*; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D056945:Hep G2 Cells; D006498:Hepatectomy; D006801:Humans; D000860:Hypoxia / Q000235:genetics; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D011379:Prognosis; D012333:RNA, Messenger / Q000378:metabolism; D036082:Receptor, EphA1 / Q000235:genetics*; D036104:Receptor, EphA2 / Q000235:genetics*
chemical_list: D036382:Ephrin-A1; D012333:RNA, Messenger; D036082:Receptor, EphA1; D036104:Receptor, EphA2