title: Increased cardiovascular stiffness and impaired age-related functional status.
abstract: Our objective was to determine if increased cardiovascular (CV) stiffness is associated with disability in middle-aged and older adults at risk for congestive heart failure. CV stiffness (brachial pulse pressure/left ventricular stroke volume indexed to body surface area) and total disability (the summed assessment of activities of daily living, mobility, and instrumental activities of daily living) were measured in 445 individuals. A subset of 109 randomly selected individuals also underwent physical function testing. Total disability was associated with CV stiffness (p = .01), driven by an association with mobility (p = .005), but not activities of daily living (p = .13) or instrumental activities of daily living (p = .61). After accounting for age, these correlations remained significant for men (p = .04), but not for women. CV stiffness was also associated with increased 400-m walk time (p = .02). In middle-aged and elderly men at risk for congestive heart failure, CV stiffness is associated with decreased mobility and physical function, and increased overall disability.
authors: Section of Cardiology, Department of Internal Medicine.
authors: Mousumi M
authors: MM
authors: Andersen
authors: Sticht Center on Aging.
authors: Stephen B
authors: SB
authors: Kritchevsky
authors: Section of Public Health Sciences.
authors: Timothy M
authors: TM
authors: Morgan
authors: Section of Public Health Sciences.
authors: Don G
authors: DG
authors: Hire
authors: Section of Cardiology, Department of Internal Medicine.
authors: Sujethra
authors: S
authors: Vasu
authors: Section of Gerontology, Department of Internal Medicine.
authors: Tina E
authors: TE
authors: Brinkley
authors: Section of Cardiology, Department of Internal Medicine.
authors: Dalane W
authors: DW
authors: Kitzman
authors: Section of Biomedical Engineering, and.
authors: Craig A
authors: CA
authors: Hamilton
authors: Section of Cardiology, Department of Internal Medicine.
authors: Sandra
authors: S
authors: Soots
authors: Section of Cardiology, Department of Internal Medicine, Section of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina. ghundley@wakehealth.edu.
authors: William G
authors: WG
authors: Hundley
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000375:Aging / Q000502:physiology*; D001916:Brachial Artery; D004185:Disability Evaluation; D005260:Female; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D051346:Mobility Limitation; D063177:Pulse Wave Analysis; D012307:Risk Factors; D011795:Surveys and Questionnaires; D059289:Vascular Stiffness / Q000502:physiology*
keywords: Cardiovascular stiffness; Congestive heart failure.; Disability