title: Sustained attention in psychosis: Neuroimaging findings.
abstract: To provide a systematic review of scientific literature on functional magnetic resonance imaging (fMRI) studies on sustained attention in psychosis. We searched PubMed to identify fMRI studies pertaining sustained attention in both affective and non-affective psychosis. Only studies conducted on adult patients using a sustained attention task during fMRI scanning were included in the final review. The search was conducted on September 10(th), 2013. 15 fMRI studies met our inclusion criteria: 12 studies were focused on Schizophrenia and 3 on Bipolar Disorder Type I (BDI). Only half of the Schizophrenia studies and two of the BDI studies reported behavioral abnormalities, but all of them evidenced significant functional differences in brain regions related to the sustained attention system. Altered functioning of the insula was found in both Schizophrenia and BDI, and therefore proposed as a candidate trait marker for psychosis in general. On the other hand, other brain regions were differently impaired in affective and non-affective psychosis: alterations of cingulate cortex and thalamus seemed to be more common in Schizophrenia and amygdala dysfunctions in BDI. Neural correlates of sustained attention seem to be of great interest in the study of psychosis, highlighting differences and similarities between Schizophrenia and BDI.
authors: Gianna Sepede, Maria Chiara Spano, Marco Lorusso, Rosa Maria Salerno, Massimo Di Giannantonio, Francesco Gambi, Department of Neuroscience and Imaging, Institute for Advanced Biomedical Technologies, University "G. D'Annunzio" of Chieti, "G. d'Annunzio" University of Chieti, 66013 Chieti Scalo (CH), Italy.
authors: Gianna
authors: G
authors: Sepede
authors: Gianna Sepede, Maria Chiara Spano, Marco Lorusso, Rosa Maria Salerno, Massimo Di Giannantonio, Francesco Gambi, Department of Neuroscience and Imaging, Institute for Advanced Biomedical Technologies, University "G. D'Annunzio" of Chieti, "G. d'Annunzio" University of Chieti, 66013 Chieti Scalo (CH), Italy.
authors: Maria Chiara
authors: MC
authors: Spano
authors: Gianna Sepede, Maria Chiara Spano, Marco Lorusso, Rosa Maria Salerno, Massimo Di Giannantonio, Francesco Gambi, Department of Neuroscience and Imaging, Institute for Advanced Biomedical Technologies, University "G. D'Annunzio" of Chieti, "G. d'Annunzio" University of Chieti, 66013 Chieti Scalo (CH), Italy.
authors: Marco
authors: M
authors: Lorusso
authors: Gianna Sepede, Maria Chiara Spano, Marco Lorusso, Rosa Maria Salerno, Massimo Di Giannantonio, Francesco Gambi, Department of Neuroscience and Imaging, Institute for Advanced Biomedical Technologies, University "G. D'Annunzio" of Chieti, "G. d'Annunzio" University of Chieti, 66013 Chieti Scalo (CH), Italy.
authors: Domenico
authors: D
authors: De Berardis
authors: Gianna Sepede, Maria Chiara Spano, Marco Lorusso, Rosa Maria Salerno, Massimo Di Giannantonio, Francesco Gambi, Department of Neuroscience and Imaging, Institute for Advanced Biomedical Technologies, University "G. D'Annunzio" of Chieti, "G. d'Annunzio" University of Chieti, 66013 Chieti Scalo (CH), Italy.
authors: Rosa Maria
authors: RM
authors: Salerno
authors: Gianna Sepede, Maria Chiara Spano, Marco Lorusso, Rosa Maria Salerno, Massimo Di Giannantonio, Francesco Gambi, Department of Neuroscience and Imaging, Institute for Advanced Biomedical Technologies, University "G. D'Annunzio" of Chieti, "G. d'Annunzio" University of Chieti, 66013 Chieti Scalo (CH), Italy.
authors: Massimo
authors: M
authors: Di Giannantonio
authors: Gianna Sepede, Maria Chiara Spano, Marco Lorusso, Rosa Maria Salerno, Massimo Di Giannantonio, Francesco Gambi, Department of Neuroscience and Imaging, Institute for Advanced Biomedical Technologies, University "G. D'Annunzio" of Chieti, "G. d'Annunzio" University of Chieti, 66013 Chieti Scalo (CH), Italy.
authors: Francesco
authors: F
authors: Gambi
keywords: Affective psychosis; Bipolar disorder; Functional magnetic resonance imaging; Insula; Non-affective psychosis; Schizophrenia; Sustained attention