title: Use of St. John's Wort in potentially dangerous combinations.
abstract: OBJECTIVE
  The objective of this study was to assess how often St. John's wort (SJW) is prescribed with medications that may interact dangerously with it.
  
  
  METHODS
  The study design was a retrospective analysis of nationally representative data from the National Ambulatory Medical Care Survey.
  
  
  METHODS
  The study setting was U.S. nonfederal outpatient physician offices.
  
  
  METHODS
  Those prescribed SJW between 1993 and 2010 were the subjects.
  
  
  METHODS
  The outcome measures were medications co-prescribed with SJW.
  
  
  RESULTS
  Twenty-eight percent (28%) of SJW visits involved a drug that has potentially dangerous interaction with SJW. These included selective serotonin reuptake inhibitors, benzodiazepines, warfarin, statins, verapamil, digoxin, and oral contraceptives.
  
  
  CONCLUSIONS
  SJW is frequently used in potentially dangerous combinations. Physicians should be aware of these common interactions and warn patients appropriately.
authors: 1 Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine , Winston-Salem, NC.
authors: Scott A
authors: SA
authors: Davis
authors: Steven R
authors: SR
authors: Feldman
authors: Sarah L
authors: SL
authors: Taylor
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use; D041743:Herb-Drug Interactions; D006801:Humans; D020902:Hypericum; D008517:Phytotherapy / Q000009:adverse effects* / Q000379:methods*; D010936:Plant Extracts / Q000008:administration & dosage* / Q000009:adverse effects*; D055656:Prescriptions; D012189:Retrospective Studies; D014481:United States
chemical_list: D000928:Antidepressive Agents; D010936:Plant Extracts