title: Acute clearance of human metapneumovirus occurs independently of natural killer cells.
abstract: Human metapneumovirus (HMPV) is a major cause of respiratory disease. The role of NK cells in protection against HMPV is unclear. We show that while HMPV-infected C57BL/6 mice had higher numbers of functional lung NK cells than mock-treated mice, comparing NK cell-depleted and control mice did not reveal differences in lung viral titers, histopathology, cytokine levels, or T cell numbers or function. These data indicate that NK cells are not required for host control of HMPV.
authors: Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee.
authors: Sherry C
authors: SC
authors: Wen
authors: Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee.
authors: Sharon J
authors: SJ
authors: Tollefson
authors: Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee.
authors: Monika
authors: M
authors: Johnson
authors: Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee.
authors: Pavlo
authors: P
authors: Gilchuk
authors: Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee.
authors: Kelli L
authors: KL
authors: Boyd
authors: Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee.
authors: Bryan
authors: B
authors: Shepherd
authors: Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee.
authors: Sebastian
authors: S
authors: Joyce
authors: Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee john.williams@vanderbilt.edu.
authors: John V
authors: http://orcid.org/0000-0001-8377-5175
authors: JV
authors: Williams
mesh_terms: D000818:Animals; D016207:Cytokines / Q000276:immunology; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008168:Lung / Q000276:immunology / Q000821:virology; D029121:Metapneumovirus / Q000276:immunology / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018184:Paramyxoviridae Infections / Q000276:immunology* / Q000821:virology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D016207:Cytokines