title: The association of baseline health and gender with small renal mass pathology.
abstract: BACKGROUND
  To explore further the association of baseline health and gender with small renal mass pathology as approximately 20% of those masses are benign and women are twice as likely as men to have benign pathology.
  
  
  METHODS
  We conducted retrospective chart reviews of patients with renal masses ≤ 4 cm who underwent partial and radical nephrectomy from 1998 to 2012. Multivariable logistic regression analysis was performed to determine demographic and clinicopathologic factors associated with malignant pathology.
  
  
  RESULTS
  In our cohort of 1726 patients, compared to patients with benign pathology, those with malignant pathology included a higher proportion of men (64.3% versus 42.7%, p < 0.01) and high American Society of Anesthesiologists class (43.8% versus 37.3%, p = 0.04), and had higher preoperative serum creatinine levels (1.1 mg/dL versus 1.0 mg/dL, p < 0.01) and larger tumors (2.5 cm versus 2.2 cm, p < 0.01). Gender-specific multivariable logistic regression analysis showed that in women factors associated with malignant pathology were high American Society of Anesthesiologists class (OR 1.57, 95% CI 1.07-2.32, p = 0.02) and tumor size (OR 1.46, 95% CI 1.19-1.79, p < 0.01). In men, factors associated with malignant pathology were tumor size (OR 1.33, 95% CI 1.06-1.67, p = 0.01) and age (OR 0.97, 95% CI 0.95-0.99, p < 0.01).
  
  
  CONCLUSIONS
  Our results are consistent with prior reports, in which male gender and larger tumor size are significantly associated with malignant small renal masses. In addition, poor baseline health as represented by a high American Society of Anesthesiologists class is significantly associated with malignant pathology in women.
authors: Memorial Sloan Kettering Cancer Center, New York, New York, USA.
authors: Wassim M
authors: WM
authors: Bazzi
authors: Sheila Z
authors: SZ
authors: Dejbakhsh
authors: Melanie
authors: M
authors: Bernstein
authors: Paul
authors: P
authors: Russo
mesh_terms: D000368:Aged; D015331:Cohort Studies; D003404:Creatinine / Q000097:blood; D003625:Data Collection; D005260:Female; D006304:Health Status; D006801:Humans; D015994:Incidence; D007680:Kidney Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D009392:Nephrectomy; D012189:Retrospective Studies; D012737:Sex Factors
chemical_list: D003404:Creatinine