title: Multifunctional Bi2S3/PLGA nanocapsule for combined HIFU/radiation therapy.
abstract: A multifunctional organic-inorganic hybrid nanocapsule based on Bi2S3-embedded poly (lactic-co-glycolic acid) (PLGA) nanocapsule has been elaborately designed to combine the merits of both polymeric shell structure and Bi2S3 nanoparticles. Hydrophobic Bi2S3 nanoparticles were successfully introduced into the PLGA nanocapsules via a facile and efficient water/oil/water (W/O/W) emulsion strategy. The elastic polymeric PLGA shell provides the excellent capability of ultrasound contrast imaging to the Bi2S3/PLGA. Meanwhile, the potential of these microcapsules to enhance the high intensity focused ultrasound (HIFU) therapy was demonstrated. Importantly, this research provided the first example of both in vitro and in vivo to demonstrate the radiosensitization effect of Bi2S3-embedded PLGA hybrid nanocapsules against prostate cancer under external X-ray irradiation. Thus, the successful integration of the Bi2S3 and PLGA nanocapsules provided an alternative strategy for the highly efficient ultrasound guided HIFU/RT synergistic therapy.
authors: Department of Ultrasound in Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R.China.
authors: Ming-hua
authors: MH
authors: Yao
authors: State Key Laboratory of High Performance Ceramic and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Science, Shanghai 200050, P.R.China.
authors: Ming
authors: M
authors: Ma
authors: State Key Laboratory of High Performance Ceramic and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Science, Shanghai 200050, P.R.China.
authors: Yu
authors: Y
authors: Chen
authors: State Key Laboratory of High Performance Ceramic and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Science, Shanghai 200050, P.R.China.
authors: Xiao-qing
authors: XQ
authors: Jia
authors: Department of Ultrasound in Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R.China.
authors: Guang
authors: G
authors: Xu
authors: Department of Ultrasound in Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R.China.
authors: Hui-xiong
authors: HX
authors: Xu
authors: State Key Laboratory of High Performance Ceramic and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Science, Shanghai 200050, P.R.China.
authors: Hang-rong
authors: HR
authors: Chen
authors: Department of Ultrasound in Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R.China. Electronic address: rong7111@hotmail.com.
authors: Rong
authors: R
authors: Wu
mesh_terms: D000818:Animals; D017209:Apoptosis; D001672:Biocompatible Materials / Q000737:chemistry*; D001729:Bismuth / Q000737:chemistry*; D002460:Cell Line; D049109:Cell Proliferation; D003287:Contrast Media / Q000737:chemistry; D004548:Elasticity; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D053769:Nanocapsules / Q000737:chemistry; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry; D011471:Prostatic Neoplasms / Q000628:therapy; D011817:Rabbits; D011838:Radiation-Sensitizing Agents / Q000737:chemistry; D013440:Sulfides / Q000737:chemistry*; D013696:Temperature; D014463:Ultrasonography; D014965:X-Rays
chemical_list: D001672:Biocompatible Materials; D003287:Contrast Media; D053769:Nanocapsules; D011108:Polymers; D011838:Radiation-Sensitizing Agents; D013440:Sulfides; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D001729:Bismuth; C049897:bismuth sulfide
keywords: HIFU; Nanocapsule; PLGA; Radiotherapy