title: Acute respiratory failure secondary to eosinophilic pneumonia following influenza vaccination in an elderly man with chronic obstructive pulmonary disease.
abstract: Acute respiratory failure with diffuse pulmonary opacities is an unusual manifestation following influenza vaccination. We report herein a patient with chronic obstructive pulmonary disease who developed fever with worsening of respiratory symptoms and severe hypoxemia requiring ventilatory support shortly after influenza vaccination. Bronchoalveolar lavage was compatible with acute eosinophilic pneumonia. Rapid clinical improvement was observed 2 weeks after systemic corticosteroid treatment, followed by radiographic improvement at 4 weeks. No disease recurrence was observed at the 6-month follow-up.
authors: Division of Pulmonary and Critical Care, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Ratchathewi, Bangkok 10400, Thailand. Electronic address: pprapaporn@gmail.com.
authors: Prapaporn
authors: P
authors: Pornsuriyasak
authors: Division of Diagnostic Radiology, Department of Diagnostic and Therapeutic Radiology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
authors: Thitiporn
authors: T
authors: Suwatanapongched
authors: Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine, Allergy and Clinical Immunology Research Group, Chulalongkorn University, Bangkok, Thailand.
authors: Jettanong
authors: J
authors: Klaewsongkram
authors: Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine, Allergy and Clinical Immunology Research Group, Chulalongkorn University, Bangkok, Thailand.
authors: Supranee
authors: S
authors: Buranapraditkun
authors: Division of Infectious Disease, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
authors: Porpon
authors: P
authors: Rotjanapan
mesh_terms: D000369:Aged, 80 and over; D006801:Humans; D007252:Influenza Vaccines / Q000009:adverse effects*; D008168:Lung / Q000000981:diagnostic imaging; D008297:Male; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications*; D011657:Pulmonary Eosinophilia / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D011859:Radiography; D012128:Respiratory Distress Syndrome / Q000175:diagnosis / Q000209:etiology*; D014611:Vaccination
chemical_list: D007252:Influenza Vaccines
keywords: Acute respiratory failure; Diffuse lung disease; Eosinophilic pneumonia; Influenza vaccination