title: Effects of bronchoalveolar lavage on refractory Mycoplasma pneumoniae pneumonia.
abstract: BACKGROUND
  This study prospectively evaluated the effect of early bronchoalveolar lavage (BAL) on refractory Mycoplasma pneumoniae pneumonia with radiologically proven large pulmonary lesions in children.
  
  
  METHODS
  A total of 35 children diagnosed as having refractory M. pneumoniae pneumonia with radiologically proven large pulmonary lesions completed the study. According to the time point of BAL, they were divided into 2 groups. In the early BAL group, BAL was performed within 3 d after admission (n = 22); in the late BAL group, BAL was performed 3 d later after admission (n = 13). Clinical effects were compared between these 2 groups.
  
  
  RESULTS
  After BAL therapy, improvement in clinical symptoms and laboratory findings as well as resolution of pulmonary lesions on radiography were obtained in all subjects. The median fever duration after admission was 4 (2-7) d and 5 (2-10) d (P < .05), and the median hospitalization duration was 7 (5-10) d and 10 (5-14) d (P < .05), respectively, in the early BAL group and the late BAL group. Approximately 7 d after admission, 67% of subjects in the early BAL group showed resolution of atelectasis on x-ray image versus a corresponding rate of 14% in the late BAL group (P < .05). Furthermore, laboratory indices recovered quicker in the early BAL group than in the late BAL group (P < .01).
  
  
  CONCLUSIONS
  BAL appeared to be efficacious and well-tolerated treatment for refractory M. pneumoniae pneumonia with radiologically proven large pulmonary lesions, and early application of BAL may be more beneficial.
authors: Department of Pulmonology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
authors: Yuanyuan
authors: Y
authors: Zhang
authors: Department of Pulmonology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
authors: Ying
authors: Y
authors: Chen
authors: Department of Pulmonology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China. drchenzm@163.com.
authors: Zhimin
authors: Z
authors: Chen
authors: Department of Pulmonology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
authors: Yunlian
authors: Y
authors: Zhou
authors: Department of Pulmonology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
authors: Yuanjian
authors: Y
authors: Sheng
authors: Department of Pulmonology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
authors: Dan
authors: D
authors: Xu
authors: Department of Pulmonology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
authors: Yingshuo
authors: Y
authors: Wang
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D018893:Bronchoalveolar Lavage / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D005260:Female; D005334:Fever / Q000209:etiology; D006801:Humans; D007902:Length of Stay; D018942:Macrolides / Q000627:therapeutic use; D008297:Male; D009177:Mycoplasma pneumoniae; D011019:Pneumonia, Mycoplasma / Q000150:complications / Q000000981:diagnostic imaging* / Q000628:therapy*; D011446:Prospective Studies; D001261:Pulmonary Atelectasis / Q000000981:diagnostic imaging / Q000209:etiology; D011859:Radiography; D019233:Retreatment; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides
keywords: bronchoalveolar lavage; children; flexible bronchoscopy; mycoplasma pneumonia; pneumonia; refractory