title: Structure based molecular inhibition of Caspase-8 for treatment of multi-neurodegenerative diseases using known natural compounds.
abstract: Neurodegenerative disorders are often associated with excessive neuronal apoptosis. It is well known that apoptosis is regulated by some intracellular proteases, such as, Caspases (cysteine-dependent, aspartate-specific proteases). In fact, Caspase-8 which is an initiator caspase, has been identified as a key mediator of neuronal apoptosis. In addition, Caspase-8 is found to be coupled with the regulation of various neurodegenerative disorders including Alzheimer׳s disease (AD), Parkinson׳s disease (PD), Huntington׳s Diseases (HD) and Dentatorubral Pallidoluysian Atrophy (DRPLA). Caspase-8 inhibition may provide an effective means of treatment for multiple neurodegenerative disorders. Therefore, the present study describes the molecular interaction of some selected natural compounds with known anti neurodegenerative properties with Caspase-8. Docking between Caspase-8 and each of these compounds (separately) was performed using 'Autodock4.2'. Out of all the selected compounds, rosmarinic acid and curcumin proved to be the most potent inhibitors of Caspase-8 with binding energy (ΔG) of -7.10 Kcal/mol and -7.08 Kcal/mol, respectively. However, further in vitro and in vivo studies are needed to validate the anti-neurodegenerative potential of these compounds.
authors: Department of Biosciences, Integral University, Lucknow.
authors: Khurshid
authors: K
authors: Ahmad
authors: College of Applied Medical Sciences, University of Ha׳il, Kingdom of Saudi Arabia.
authors: Saif
authors: S
authors: Khan
authors: Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, India.
authors: Mohd
authors: M
authors: Adil
authors: Department of Biosciences, Integral University, Lucknow.
authors: Mohd
authors: M
authors: Saeed
authors: Department of Biosciences, Integral University, Lucknow.
authors: Ashwini Kumar
authors: AK
authors: Srivastava
keywords: Caspase 8; Molecular Docking; Natural compounds; Neurodegenerative disorders