title: Action at a distance: functional drug delivery using electromagnetic-field-responsive polypyrrole nanowires.
abstract: In this work, we introduce a free-standing, vertically aligned conductive polypyrrole (Ppy) architecture that can serve as a high-capacity drug reservoir. This novel geometric organization of Ppy provides a new platform for improving the drug-loading efficiency. Most importantly, we present the first formal evidence that an impregnated drug (dexamethasone, DEX) can be released on demand by a focal, pulsatile electromagnetic field (EMF). This remotely controlled, on-off switchable polymer system provides a framework for implantable constructs that can be placed in critical areas of the body without any physical contact (such as percutaneous electrodes) with the Ppy, contributing to a low "foreign body" footprint. We demonstrate this possibility by using a BV-2 microglia culture model in which reactive oxygen species (ROS) and inducible nitric oxide synthase (iNOS) expression was attenuated in response to DEX released from EMF-stimulated Ppy.
authors: Center for Paralysis Research, Department of Basic Medical Sciences, College of Veterinary Medicine and ‡Weldon School of Biomedical Engineering, College of Engineering, Purdue University , West Lafayette, Indiana 47907, United States.
authors: Wen
authors: W
authors: Gao
authors: Jianming
authors: J
authors: Li
authors: John
authors: J
authors: Cirillo
authors: Richard
authors: R
authors: Borgens
authors: Youngnam
authors: Y
authors: Cho
mesh_terms: D003907:Dexamethasone / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D004574:Electromagnetic Fields; D053770:Nanowires / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*; D017382:Reactive Oxygen Species
chemical_list: D011108:Polymers; D011758:Pyrroles; D017382:Reactive Oxygen Species; C067635:polypyrrole; D003907:Dexamethasone