title: Defective expression of scavenger receptors in celiac disease mucosa.
abstract: Celiac disease (CD) is a gluten sensitive enteropathy characterized by a marked infiltration of the mucosa with immune cells, over-production of inflammatory cytokines and epithelial cell damage. The factors/mechanisms that sustain and amplify the ongoing mucosal inflammation in CD are not however fully understood. Here, we have examined whether in CD there is a defective clearance of apoptotic cells/bodies, a phenomenon that helps promote tolerogenic signals thus liming pathogenic responses. Accumulation of apoptotic cells and bodies was more pronounced in the epithelial and lamina propria compartments of active CD patients as compared to inactive CD patients and normal controls. Expression of scavenger receptors, which are involved in the clearance of apoptotic cells/bodies, namely thrombospondin (TSP)-1, CD36 and CD61, was significantly reduced in active CD as compared to inactive CD and normal mucosal samples. Consistently, lamina propria mononuclear cells (LPMC) of active CD patients had diminished ability to phagocyte apoptotic cells. Interleukin (IL)-15, IL-21 and interferon-γ, cytokines over-produced in active CD, inhibited the expression of TSP-1, CD36, and CD61 in normal intestinal LPMC. These results indicate that CD-related inflammation is marked by diminished clearance of apoptotic cells/bodies, thus suggesting a role for such a defect in the ongoing mucosal inflammation in this disorder.
authors: Dipartimento di Medicina dei Sistemi, Università Tor Vergata, Rome, Italy.
authors: Maria Laura
authors: ML
authors: Cupi
authors: Dipartimento di Medicina dei Sistemi, Università Tor Vergata, Rome, Italy.
authors: Massimiliano
authors: M
authors: Sarra
authors: Dipartimento di Medicina dei Sistemi, Università Tor Vergata, Rome, Italy.
authors: Daniela
authors: D
authors: De Nitto
authors: Dipartimento di Medicina dei Sistemi, Università Tor Vergata, Rome, Italy.
authors: Eleonora
authors: E
authors: Franzè
authors: Dipartimento di Medicina dei Sistemi, Università Tor Vergata, Rome, Italy.
authors: Irene
authors: I
authors: Marafini
authors: Dipartimento di Medicina dei Sistemi, Università Tor Vergata, Rome, Italy.
authors: Ivan
authors: I
authors: Monteleone
authors: Dipartimento di Medicina dei Sistemi, Università Tor Vergata, Rome, Italy.
authors: Giovanna
authors: G
authors: Del Vecchio Blanco
authors: Dipartimento di Medicina dei Sistemi, Università Tor Vergata, Rome, Italy.
authors: Omero Alessandro
authors: OA
authors: Paoluzi
authors: Dipartimento di Medicina dei Sistemi, Università Tor Vergata, Rome, Italy.
authors: Davide
authors: D
authors: Di Fusco
authors: Dipartimento di Medicina dei Sistemi, Università Tor Vergata, Rome, Italy.
authors: Paolo
authors: P
authors: Gentileschi
authors: Dipartimento di Medicina dei Sistemi, Università Tor Vergata, Rome, Italy.
authors: Angela
authors: A
authors: Ortenzi
authors: Dipartimento di Medicina dei Sistemi, Università Tor Vergata, Rome, Italy.
authors: Alfredo
authors: A
authors: Colantoni
authors: Dipartimento di Medicina dei Sistemi, Università Tor Vergata, Rome, Italy.
authors: Francesco
authors: F
authors: Pallone
authors: Dipartimento di Medicina dei Sistemi, Università Tor Vergata, Rome, Italy.
authors: Giovanni
authors: G
authors: Monteleone
mesh_terms: D017209:Apoptosis; D016022:Case-Control Studies; D002446:Celiac Disease / Q000378:metabolism*; D002478:Cells, Cultured; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism* / Q000473:pathology; D010587:Phagocytosis; D051116:Receptors, Scavenger / Q000235:genetics / Q000378:metabolism*
chemical_list: D051116:Receptors, Scavenger