title: Hypotensive effect of retabolil correcting the concentration of aldosterone during stress exposures.
abstract: Male rats were exposed to single or repeated (19 days) cold treatment (4°C) and non-cold stress (60-min shaking on a laboratory shuttle device). Retabolil had a hypotensive effect, which was accompanied by the prevention of a stress-induced increase in the concentration of a hypertensive hormone aldosterone. Under conditions of repeated stress, these effects were realized via μ-opioid receptors. Our results suggest that retabolil can be used as a hypotensive and aldosterone-blocking agent, at least during stress exposure in animals (and probably in humans).
authors: Research Institute of Clinical Immunology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
authors: T A
authors: TA
authors: Obut
authors: M V
authors: MV
authors: Ovsyukova
authors: S A
authors: SA
authors: Egorova
authors: T A
authors: TA
authors: Erdynieva
authors: T Yu
authors: TY
authors: Dement'eva
authors: E T
authors: ET
authors: Obut
authors: A G
authors: AG
authors: Gorobchuk
mesh_terms: D000450:Aldosterone / Q000097:blood*; D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000077603:Nandrolone Decanoate; D051381:Rats; D017208:Rats, Wistar; D017450:Receptors, Opioid, mu / Q000378:metabolism
chemical_list: D000959:Antihypertensive Agents; D017450:Receptors, Opioid, mu; D000450:Aldosterone; D009277:Nandrolone; D000077603:Nandrolone Decanoate