title: Factor structure, convergent validity, and discriminant validity of the NIH Toolbox Cognitive Health Battery (NIHTB-CHB) in adults.
abstract: The objective of this study is to evaluate the construct validity of the NIH Neurobehavioral Toolbox Cognitive Health Battery (NIHTB-CHB) in adults. Confirmatory factor analysis was used to evaluate the dimensional structure underlying the NIHTB-CHB and Gold Standard tests chosen to serve as concurrent validity criteria for the NIHTB-CHB. These results were used to evaluate the convergent and discriminant validity of the NIHTB-CHB in adults ranging from 20 to 85 years of age. Five dimensions were found to explain the correlations among NIHTB-CHB and Gold Standard tests: Vocabulary, Reading, Episodic Memory, Working Memory and Executive Function/Processing Speed. NIHTB-CHB measures and their Gold Standard analogues defined factors in a pattern that broadly supported the convergent and discriminant validity of the NIHTB-CHB tests. This 5-factor structure was found to be invariant across 20-60 year old (N=159) and 65-85 year old (N=109) age groups that were included in the current validity study. Second order Crystallized Abilities (Vocabulary and Reading) and Fluid Abilities (Episodic Memory, Working Memory, Executive/Speed) factors parsimoniously explained correlations among the five first order factors. These results suggest that the NIHTB-CHB will provide both fine-grained and broad characterization of cognition across the adult age span.
authors: 1Department of Neurology,University of California,Davis,California.
authors: Dan
authors: D
authors: Mungas
authors: 2Department of Psychiatry,University of California,San Diego,California.
authors: Robert
authors: R
authors: Heaton
authors: 3Rusk Institute / Department of Rehabilitation Medicine,New York University,New York,New York.
authors: David
authors: D
authors: Tulsky
authors: 4Institute of Child Development,University of Minnesota,Minneapolis,Minnesota.
authors: Philip David
authors: PD
authors: Zelazo
authors: 5Department of Medical Social Sciences,Northwestern University,Chicago,Illinois.
authors: Jerry
authors: J
authors: Slotkin
authors: 5Department of Medical Social Sciences,Northwestern University,Chicago,Illinois.
authors: David
authors: D
authors: Blitz
authors: 5Department of Medical Social Sciences,Northwestern University,Chicago,Illinois.
authors: Jin-Shei
authors: JS
authors: Lai
authors: 5Department of Medical Social Sciences,Northwestern University,Chicago,Illinois.
authors: Richard
authors: R
authors: Gershon
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003071:Cognition / Q000502:physiology*; D016002:Discriminant Analysis; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009316:National Institutes of Health (U.S.) / Q000592:standards*; D009483:Neuropsychological Tests / Q000592:standards*; D015203:Reproducibility of Results; D014481:United States; D054928:Validation Studies as Topic; D055815:Young Adult