title: Metal based pharmacologically active complexes of Cu(II), Ni(II) and Zn(II): synthesis, spectral, XRD, antimicrobial screening, DNA interaction and cleavage investigation.
abstract: The present contribution reports a thorough characterization of newly obtained metallointercalators incorporating Schiff bases, formed by the condensation of N-acetoacetyl-o-toluidine with 1-amino-4-nitrobenzene (L(1))/1-amino-4-chlorobenzene (L(2)) as main ligand and 1,10-phenanthroline as co-ligand respectively. The characterization of newly formed metallointercalators has been done by (1)H NMR, UV-Vis, IR, EPR spectroscopy and molar conductivity studies. X-ray powder diffraction illustrates that they are crystalline nature. Binding interaction of these complexes with calf thymus (CT-DNA) has been investigated by emission, absorption, viscosity, cyclic voltammetry and differential pulse voltammetry. DNA binding experiments results reveal that the synthesized complexes interact with DNA through intercalative mode. The in vitro antibacterial and antifungal assay indicate that these complexes are good antimicrobial agents against various pathogens. The DNA cleavage exhibits that they act as efficient cleaving agents.
authors: Research Department of Chemistry, VHNSN College, Virudhunagar 626 001, India. Electronic address: drn_raman@yahoo.co.in.
authors: Natarajan
authors: N
authors: Raman
authors: Research Department of Chemistry, VHNSN College, Virudhunagar 626 001, India.
authors: Rajkumar
authors: R
authors: Mahalakshmi
authors: Research Department of Chemistry, VHNSN College, Virudhunagar 626 001, India.
authors: T
authors: T
authors: Arun
authors: Research Department of Chemistry, VHNSN College, Virudhunagar 626 001, India.
authors: S
authors: S
authors: Packianathan
authors: Mepco Schlenk Engineering College, Sivakasi 626 005, India.
authors: R
authors: R
authors: Rajkumar
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002417:Cattle; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D053837:DNA Cleavage / Q000187:drug effects; D055664:Electrochemical Techniques; D004578:Electron Spin Resonance Spectroscopy; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000528:radiation effects; D009532:Nickel / Q000737:chemistry*; D010618:Phenanthrolines / Q000737:chemistry; D012545:Schiff Bases / Q000737:chemistry; D014783:Viscosity; D014961:X-Ray Diffraction; D015032:Zinc / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D056831:Coordination Complexes; D010618:Phenanthrolines; D012545:Schiff Bases; D003300:Copper; D009532:Nickel; D004247:DNA; C427203:calf thymus DNA; D015032:Zinc; C025205:1,10-phenanthroline
keywords: 1,10-Phenanthroline; Antibacterial investigation; Antifungal investigation; DNA damage; DNA interaction; Fluorescence; XRD