title: Contemporary profile of acute heart failure in Southern Nigeria: data from the Abeokuta Heart Failure Clinical Registry.
abstract: OBJECTIVE
  The aim of this study was to determine the contemporary profile, clinical characteristics, and intrahospital outcomes of acute heart failure (AHF) in an African urban community.
  
  
  BACKGROUND
  There are limited data on the current burden and characteristics of AHF in Nigerian Africans.
  
  
  METHODS
  Comprehensive and detailed clinical and sociodemographic data were prospectively collected from 452 consecutive patients presenting with AHF to the only tertiary hospital in Abeokuta, Nigeria (population about 1 million) over a 2-year period.
  
  
  RESULTS
  The mean age was 56.6 ± 15.3 years (57.3 ± 13.4 years for men, 55.7 ± 17.1 years for women), and 204 patients (45.1%) were women. Overall, 415 subjects (91.8%) presented with de novo AHF. The most common risk factor for heart failure was hypertension (pre-existing in 64.3% of patients). Type 2 diabetes mellitus was present in 41 patients (10.0%). Hypertensive heart failure was the most common etiological cause of heart failure, responsible for 78.5% of cases. Dilated cardiomyopathy (7.5%), cor pulmonale (4.4%), pericardial disease (3.3%), rheumatic heart disease (2.4%), and ischemic heart disease were less common (0.4%) causes. The majority of subjects (71.2%) presented with left ventricular dysfunction (mean left ventricular ejection fraction 43.9 ± 9.0%), with valvular dysfunction and abnormal left ventricular geometry frequently documented. The mean duration of hospital stay was 11.4 ± 9.1 days, and intrahospital mortality was 3.8%.
  
  
  CONCLUSIONS
  Compared with those in high-income countries, patients presenting with AHF in Abeokuta, Nigeria, are relatively younger and still of working age. It is also more common in men and associated with severe symptoms because of late presentation. Intrahospital mortality is similar to that in other parts of the world.
authors: Division of Cardiology, Department of Medicine, University College Hospital, Ibadan, Nigeria; Soweto Cardiovascular Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Electronic address: osogah56156@yahoo.com.
authors: Okechukwu S
authors: OS
authors: Ogah
authors: NHMRC Centre of Research Excellence to Reduce Inequality in Heart Disease, Baker IDI Heart and Diabetes Institute, Melbourne, Australia.
authors: Simon
authors: S
authors: Stewart
authors: Division of Cardiology, Department of Medicine, University College Hospital, Ibadan, Nigeria.
authors: Ayodele O
authors: AO
authors: Falase
authors: Department of Epidemiology and Medical Statistics, College of Medicine, University of Ibadan, Ibadan, Nigeria.
authors: Joshua O
authors: JO
authors: Akinyemi
authors: Department of Medicine, Sacred Heart Hospital, Lantoro, Abeokua, Nigeria.
authors: Gail D
authors: GD
authors: Adegbite
authors: Department of Medicine, Sacred Heart Hospital, Lantoro, Abeokua, Nigeria.
authors: Albert A
authors: AA
authors: Alabi
authors: Department of Medicine, Federal Medical Centre, Abeokua, Nigeria.
authors: Akinlolu A
authors: AA
authors: Ajani
authors: Department of Medicine, Federal Medical Centre, Abeokua, Nigeria.
authors: Julius O
authors: JO
authors: Adesina
authors: Department of Medicine, Federal Medical Centre, Abeokua, Nigeria.
authors: Amina
authors: A
authors: Durodola
authors: Soweto Cardiovascular Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Hatter Institute for Cardiovascular Research in Africa & IIDMM, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
authors: Karen
authors: K
authors: Sliwa
mesh_terms: D000208:Acute Disease; D017281:Cost of Illness; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006333:Heart Failure / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D009549:Nigeria / Q000453:epidemiology; D011379:Prognosis; D011446:Prospective Studies; D012042:Registries; D012307:Risk Factors; D012959:Socioeconomic Factors; D014504:Urban Health
keywords: Nigeria; acute heart failure; clinical registry; health outcomes