title: In Vivo Antioxidant and Anti-Skin-Aging Activities of Ethyl Acetate Extraction from Idesia polycarpa Defatted Fruit Residue in Aging Mice Induced by D-Galactose.
abstract: Two different concentrations of D-galactose (D-gal) induced organism and skin aging in Kunming mice were used to examine comprehensively the antioxidant and antiaging activities of ethyl acetate extraction (EAE) from Idesia polycarpa defatted fruit residue for the first time. The oxygen radical absorbance capacity (ORAC) of EAE was 13.09 ± 0.11  μ mol Trolox equivalents (TE)/mg, which showed EAE had great in vitro free radical scavenging and antioxidant activity. Biochemical indexes and morphological analysis of all tested tissues showed that EAE could effectively improve the total antioxidant capacity (T-AOC) of the antioxidant defense system of the aging mice, enhance the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) of tissues and serum, increase glutathione (GSH) content and decrease the malondialdehyde (MDA) content, and maintain the skin collagen, elastin, and moisture content. Meanwhile, EAE could effectively attenuate the morphological damage in brain, liver, kidney, and skin induced by D-gal and its effect was not less than that of the well-known L-ascorbic acid (VC) and α -tocopherol (VE). Overall, EAE is a potent natural antiaging agent with great antioxidant activity, which can be developed as a new medicine and cosmetic for the treatment of age-related conditions.
authors: National and Local Joint Engineering Laboratory for Energe Plant Bio-Oil Production and Application, Sichuan Key Laboratory of Resource Biology and Biopharmaceutical Engineering, Key Laboratory of Bio-Resources and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, Sichuan 610064, China.
authors: Yang
authors: 0000-0002-7719-1808
authors: Y
authors: Ye
authors: National and Local Joint Engineering Laboratory for Energe Plant Bio-Oil Production and Application, Sichuan Key Laboratory of Resource Biology and Biopharmaceutical Engineering, Key Laboratory of Bio-Resources and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, Sichuan 610064, China.
authors: Ran-Ran
authors: RR
authors: Jia
authors: National and Local Joint Engineering Laboratory for Energe Plant Bio-Oil Production and Application, Sichuan Key Laboratory of Resource Biology and Biopharmaceutical Engineering, Key Laboratory of Bio-Resources and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, Sichuan 610064, China.
authors: Lin
authors: 0000-0002-4400-5802
authors: L
authors: Tang
authors: National and Local Joint Engineering Laboratory for Energe Plant Bio-Oil Production and Application, Sichuan Key Laboratory of Resource Biology and Biopharmaceutical Engineering, Key Laboratory of Bio-Resources and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, Sichuan 610064, China.
authors: Fang
authors: F
authors: Chen