title: N-methyl-d-aspartate glutamate receptor (NMDA-R) antibodies in mild cognitive impairment and dementias.
abstract: The N-methyl-d-aspartate glutamate receptor (NMDA-R) plays a central role in learning and memory and has therefore a potential role in the pathophysiology of neuropsychiatric disorders. Recently, we detected NMDA-R autoantibodies in aged healthy volunteers without neuropsychiatric disorders. Since studies showing the involvement of NMDA-R antibodies in mild cognitive impairment and different forms of dementia are rare, we examined NMDA-R antibodies (Abs) in serum of 46 patients with Alzheimer's disease (AD), 26 patients with subcortical ischemic vascular dementia (SIVD), 18 patients with frontotemporal dementia (FTD), 11 patients with Lewy body disease (LBD) and 33 patients with mild cognitive impairment (MCI) and in 21 healthy aged, gender-matched volunteers. While IgM and/or IgA NMDA-R Abs were present in all groups, IgG was only detected in one AD sample. Seropositivity could be correlated with the presence of co-symptoms: MCI and AD patients suffering from depression and AD and SIVD patients with a psychosis were almost all NMDA-R Ab positive. We conclude that the presence of NMDA-R Abs in dementia could influence the incidence of comorbid depressive and/or psychotic states.
authors: Department of Psychiatry, University of Magdeburg, Magdeburg, Germany. Electronic address: stefan.busse@med.ovgu.de.
authors: Stefan
authors: S
authors: Busse
authors: Institute for Experimental Immunology, Affiliated to Euroimmun, Lübeck, Lübeck, Germany.
authors: Britta
authors: B
authors: Brix
authors: Department of Psychiatry, University of Magdeburg, Magdeburg, Germany.
authors: Ralf
authors: R
authors: Kunschmann
authors: Department of Psychiatry, University of Magdeburg, Magdeburg, Germany; Center for Behavioral Brain Sciences, Magdeburg, Germany.
authors: Bernhard
authors: B
authors: Bogerts
authors: Institute for Experimental Immunology, Affiliated to Euroimmun, Lübeck, Lübeck, Germany.
authors: Winfried
authors: W
authors: Stoecker
authors: Department of Pediatric Pulmonology & Allergology, Medical University of Hannover, Hannover, Germany.
authors: Mandy
authors: M
authors: Busse
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology; D060825:Cognitive Dysfunction / Q000097:blood / Q000276:immunology*; D015331:Cohort Studies; D003704:Dementia / Q000097:blood / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D016194:Receptors, N-Methyl-D-Aspartate
keywords: Alzheimer's disease (AD); Frontotemporal dementia (FTD); Lewy body disease (LBD); Mild cognitive impairment (MCI); NMDA-receptor antibodies; Subcortical ischemic vascular dementia (SIVD)