title: Total pancreatectomy for primary pancreatic neoplasms: renaissance of an unpopular operation.
abstract: OBJECTIVE
  To assess the long-term survival and quality of life in total pancreatectomies and to identify risk factors for perioperative morbidity and mortality.
  
  
  BACKGROUND
  Total pancreatectomy may be required in locally advanced or centrally located pancreatic neoplasms to achieve complete tumor clearance, but available data on short- and long-term results are limited.
  
  
  METHODS
  A total of 434 consecutive total pancreatectomies for primary pancreatic or periampullary tumors were performed between October 2001 and September 2012 at the authors' institution and were prospectively documented and analyzed. Long-term outcome was assessed using Kaplan-Meier and quality of life analysis (EORTC-QLQ-C30 and PAN26). Uni- and multivariate analysis was performed to identify perioperative risk factors and predictors for long-term survival.
  
  
  RESULTS
  Extended total pancreatectomies were performed in 54% of cases, with arterial and portal vein resections in 15% and 32%, respectively. Overall 30-day and in-hospital mortality rates were 3.7% and 7.8%, respectively. High blood loss, long operative time, and arterial resections were independently associated with increased perioperative mortality (P ≤ 0.018). In malignant disease, median and 5-year survival were good for standard total pancreatectomies (28.6 months and 24.3%, respectively) and were significantly impaired after vascular resections (P < 0.001). Poor tumor grading, high American Joint Commission on Cancer tumor stage, age more than 70 years, and an R1 resection were independent prognostic parameters. Long-term global quality of life was comparable with a matched healthy control group.
  
  
  CONCLUSIONS
  Standard total pancreatectomy, if needed, is associated with good long-term outcome in pancreatic cancer. Marked surgical morbidity and impaired survival associated with vascular resections reflect the invasiveness of extended total pancreatectomies and the underlying advanced malignant disease.
authors: *Department of General, Visceral, and Transplantation Surgery; †Division of Biostatistics; and ‡Institute of Pathology, University of Heidelberg, Heidelberg, Germany.
authors: Werner
authors: W
authors: Hartwig
authors: Alexander
authors: A
authors: Gluth
authors: Ulf
authors: U
authors: Hinz
authors: Frank
authors: F
authors: Bergmann
authors: Pauline E R
authors: PE
authors: Spronk
authors: Thilo
authors: T
authors: Hackert
authors: Jens
authors: J
authors: Werner
authors: Markus W
authors: MW
authors: Büchler
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D005858:Germany / Q000453:epidemiology; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy / Q000379:methods* / Q000401:mortality; D010190:Pancreatic Neoplasms / Q000601:surgery*; D011446:Prospective Studies; D011788:Quality of Life; D012307:Risk Factors; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers