title: No association between MTR rs1805087 A > G polymorphism and non-Hodgkin lymphoma susceptibility: evidence from 11 486 subjects.
abstract: Numerous investigations have examined the association between MTR rs1805087 A> G polymorphism and non-Hodgkin lymphoma (NHL) susceptibility, yet have generated conflicting results. Therefore, the current meta-analysis was performed to comprehensively reevaluate this association. A systematic literature search of PubMed and Embase databases was conducted to seek eligible publications. The final analysis included 13 publications with a total of 4555 cases of NHL and 6931 controls. Overall, pooled analysis did not yield any statistically significant association between MTR rs1805087 A> G and NHL risk. Stratification analysis by source of controls showed a decreased risk of NHL with the polymorphism of interest in hospital-based studies, while no significant association was observed when data were stratified by ethnicity, sample size and NHL subtype. This meta-analysis does not indicate a major role of the MTR rs1805087 A> G polymorphism in modulating NHL risk. However, well-designed prospective studies with large sample sizes are encouraged to validate our findings.
authors: State Key Laboratory of Oncology in South China, Department of Experimental Research, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center , Guangzhou, Guangdong , China.
authors: Jing
authors: J
authors: He
authors: Fang
authors: F
authors: Wang
authors: Jin-Hong
authors: JH
authors: Zhu
authors: Wei
authors: W
authors: Chen
authors: Zhuo
authors: Z
authors: Cui
authors: Wei-Hua
authors: WH
authors: Jia
mesh_terms: D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; C585801:MTR protein, human
keywords: MTR; NHL; meta-analysis; susceptibility