title: The effects of dendrimer size and central metal ions on photosensitizing properties of dendrimer porphyrins.
abstract: A series of dendrimer porphyrins (G(n)DP(M); n = generation of dendrimer, n = 1-3; M = coordination metal, M = freebase, Zn, Pt) were prepared and their photosensitizing properties were compared. All G(n)DP(M) exhibited sharp absorption in organic solvents. However, the Soret absorptions of G(n)DP(M)(CO(2)H) in 10 mM phosphate buffer solution (pH = 7.4) are broader than those of G(n)DP(M) in organic solvents, indicating inhomogeneous microenvironments of the focal porphyrin derivatives. All G(3)DP(M)(CO(2)H) successfully formed globular polyion complex micelles that were uniform in size. Under dark conditions, all G(n)DP(M)(CO(2)H) showed negligible cytotoxicity. However, all samples exhibited concentration-dependent photocytotoxicity under light irradiation. In vitro photocytotoxicity as well as singlet oxygen generation revealed that G(3)DP(Zn)(CO(2)H) is the best dendritic PS of the three different dendrimer porphyrin species.
authors: Department of Chemistry, Yonsei University , Seodaemun-Gu, Seoul , Korea.
authors: Joo-Ho
authors: JH
authors: Kim
authors: Hee-Jae
authors: HJ
authors: Yoon
authors: Jinsook
authors: J
authors: Sim
authors: Sang-Yong
authors: SY
authors: Ju
authors: Woo-Dong
authors: WD
authors: Jang
mesh_terms: D065966:Absorption, Physicochemical; D002470:Cell Survival / Q000187:drug effects; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008027:Light; D008665:Metalloporphyrins / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000528:radiation effects; D008823:Micelles; D015394:Molecular Structure; D010316:Particle Size; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000528:radiation effects; D010984:Platinum / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D015032:Zinc / Q000737:chemistry*
chemical_list: D050091:Dendrimers; D004337:Drug Carriers; D008665:Metalloporphyrins; D008823:Micelles; D017319:Photosensitizing Agents; D012997:Solvents; D010984:Platinum; D015032:Zinc
keywords: Copolymer; HeLa cells; dendrimer; drug delivery