title: Measurement of blood-brain barrier permeability with t1-weighted dynamic contrast-enhanced MRI in brain tumors: a comparative study with two different algorithms.
abstract: The purpose of this study was to assess the feasibility of measuring different permeability parameters with T1-weighted dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) in order to investigate the blood brain-barrier permeability associated with different brain tumors. The Patlak algorithm and the extended Tofts-Kety model were used to this aim. Twenty-five adult patients with tumors of different histological grades were enrolled in this study. MRI examinations were performed at 1.5 T. Multiflip angle, fast low-angle shot, and axial 3D T1-weighted images were acquired to calculate T1 maps, followed by a DCE acquisition. A region of interest was placed within the tumor of each patient to calculate the mean value of different permeability parameters. Differences in permeability measurements were found between different tumor grades, with higher histological grades characterized by higher permeability values. A significant difference in transfer constant (K (trans)) values was found between the two methods on high-grade tumors; however, both techniques revealed a significant correlation between the histological grade of tumors and their K (trans) values. Our results suggest that DCE acquisition is feasible in patients with brain tumors and that K (trans) maps can be easily obtained by these two algorithms, even if the theoretical model adopted could affect the final results.
authors: Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Maternal and Child Health, University of Genoa, 16132 Genoa, Italy ; Magnetic Resonance Research Centre on Nervous System Diseases, University of Genoa, 16132 Genoa, Italy.
authors: Maurizio
authors: 0000-0001-6618-3784
authors: M
authors: Bergamino
authors: Department of Diagnostic and Interventional Neuroradiology, San Martino University Hospital, 16132 Genoa, Italy.
authors: Laura
authors: L
authors: Saitta
authors: Department of Diagnostic and Interventional Neuroradiology, San Martino University Hospital, 16132 Genoa, Italy.
authors: Laura
authors: L
authors: Barletta
authors: Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Maternal and Child Health, University of Genoa, 16132 Genoa, Italy ; Magnetic Resonance Research Centre on Nervous System Diseases, University of Genoa, 16132 Genoa, Italy.
authors: Laura
authors: L
authors: Bonzano
authors: Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Maternal and Child Health, University of Genoa, 16132 Genoa, Italy ; Magnetic Resonance Research Centre on Nervous System Diseases, University of Genoa, 16132 Genoa, Italy.
authors: Giovanni Luigi
authors: GL
authors: Mancardi
authors: Department of Diagnostic and Interventional Neuroradiology, San Martino University Hospital, 16132 Genoa, Italy.
authors: Lucio
authors: L
authors: Castellan
authors: Department of Pathology, San Martino University Hospital, 16132 Genoa, Italy.
authors: Jean Louis
authors: JL
authors: Ravetti
authors: Magnetic Resonance Research Centre on Nervous System Diseases, University of Genoa, 16132 Genoa, Italy ; Department of Diagnostic and Interventional Neuroradiology, San Martino University Hospital, 16132 Genoa, Italy ; Department of Health Sciences, University of Genoa, 16132 Genoa, Italy.
authors: Luca
authors: L
authors: Roccatagliata