title: Alternative splicing in Drosophila neuronal development.
abstract: Post-transcriptional pre-mRNA splicing has emerged as a critical step in the gene expression cascade greatly influencing diversification and spatiotemporal control of the proteome in many developmental processes. The percentage of genes targeted by alternative splicing (AS) is shown to be over 95% in humans and 60% in Drosophila. Therefore, it is evident that deregulation of this process underlies many genetic diseases. Among all tissues, the brain shows the highest transcriptome diversity, which is not surprising in view of the complex inter- and intracellular networks underlying the development of this organ. Reports of isoforms known to function at different steps during Drosophila nervous system development are rapidly increasing as well as knowledge on their regulation and function, highlighting the role of AS during neuronal development in Drosophila.
authors: Institute of Human Genetics, University Medical Center Freiburg , Freiburg , Germany.
authors: Carmen
authors: C
authors: Mohr
authors: Britta
authors: B
authors: Hartmann
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D004330:Drosophila / Q000235:genetics*; D029721:Drosophila Proteins / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental; D055495:Neurogenesis; D009474:Neurons / Q000166:cytology
chemical_list: D029721:Drosophila Proteins
keywords: Alternative splicing; Drosophila; neurogenesis; post-transcriptional regulation