title: Injectable microbeads with a thermo-responsive shell and a pH-responsive core as a dual-switch-controlled release system.
abstract: Treating inflammation with a dual-switch-controlled release system: The release of a drug from the developed microbead system occurs only in response to both an increase in local temperature and an acidic environmental pH. This dual-switch-controlled release system has the advantages of distinguishing between inflamed and healthy tissues to improve treatment efficacy.
authors: Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan, 30013, ROC; Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan, 30013, ROC.
authors: Wei-Lun
authors: WL
authors: Chiang
authors: Yi-Chen
authors: YC
authors: Hu
authors: Hung-Yi
authors: HY
authors: Liu
authors: Chun-Wen
authors: CW
authors: Hsiao
authors: Radhakrishnan
authors: R
authors: Sureshbabu
authors: Chih-Man
authors: CM
authors: Yang
authors: Min-Fan
authors: MF
authors: Chung
authors: Wei-Tso
authors: WT
authors: Chia
authors: Hsing-Wen
authors: HW
authors: Sung
mesh_terms: D016503:Drug Delivery Systems; D006863:Hydrogen-Ion Concentration; D018613:Microscopy, Confocal; D008855:Microscopy, Electron, Scanning; D008863:Microspheres
keywords: controlled release; drug delivery; inflammatory diseases; smart carriers; stimuli-responsive materials