title: [Nationwide surveillance of parenteral antibiotics containing meropenem activities against clinically isolated strains in 2012].
abstract: The nationwide surveillance of antibacterial susceptibility to meropenem (MEPM) and other parenteral antibiotics against clinical isolates during 2012 in Japan was conducted. A total of 2985 strains including 955 strains of Gram-positive bacteria, 1782 strains of Gram-negative bacteria, and 248 strains of anaerobic bacteria obtained from 31 medical institutions were examined. The results were as follows; 1. MEPM was more active than the other carbapenem antibiotics tested against Gram-negative bacteria, especially against enterobacteriaceae and Haemophilus influenzae. MEPM was also active against most of the species tested in Gram-positive and anaerobic bacteria, except for multi-drug resistant strains including methicillin-resistant Staphylococcus aureus (MRSA). 2. Of all species tested, there were no species, which MIC90 of MEPM was more than 4-fold higher than those in our previous studies in 2009 or 2006. Therefore, the tendency to increase in antimicrobial resistance rates was not observed. 3. MEPM resistance against Pseudomonas aeruginosa was 17.8% (56/315 strains). Compared to our previous results, it was the lowest than that in 2006 and 2009. 4. Carbapenem-resistant Klebsiella pneumoniae, and multi-drug-resistant Acinetobacter species, which emerged in worldwide, were not observed. 5. The proportion of extended-spectrum beta-lactamase (ESBL) strains was 6.2% (59/951 strains) in enterobacteriaceae, which increased compared with that of our previous studies in 2009 or before. Whereas, the proportion of metallo-beta-lactamase strains was 1.6% (5/315 strains) in P. aeruginosa, which was stable. In conclusion, the results from this surveillance suggest that MEPM retains its potent and broad antibacterial activity and therefore is a clinically useful carbapenem for serious infections treatment at present, 17 years passed after available for commercial use in Japan.
authors: Keizo
authors: K
authors: Yamaguchi
authors: Yoshikazu
authors: Y
authors: Ishii
authors: Kazuhiro
authors: K
authors: Tateda
authors: Morihiro
authors: M
authors: Iwata
authors: Naoki
authors: N
authors: Watanabe
authors: Masaaki
authors: M
authors: Shinagawa
authors: Hiroyuki
authors: H
authors: Kayaba
authors: Masahiko
authors: M
authors: Kimura
authors: Akira
authors: A
authors: Suwabe
authors: Mitsuo
authors: M
authors: Kaku
authors: Yuko
authors: Y
authors: Abe
authors: Keiji
authors: K
authors: Kanemitsu
authors: Nobuyuki
authors: N
authors: Taniguchi
authors: Masami
authors: M
authors: Murakami
authors: Shigefumi
authors: S
authors: Maesaki
authors: Toru
authors: T
authors: Kawamura
authors: Fumio
authors: F
authors: Nomura
authors: Masaharu
authors: M
authors: Watanabe
authors: Harushige
authors: H
authors: Kanno
authors: Hajime
authors: H
authors: Horiuchi
authors: Yoko
authors: Y
authors: Tazawa
authors: Shigemi
authors: S
authors: Kondo
authors: Shigeki
authors: S
authors: Misawa
authors: Hiromu
authors: H
authors: Takemura
authors: Hideki
authors: H
authors: Nakashima
authors: Takayuki
authors: T
authors: Matsuto
authors: Yoshinori
authors: Y
authors: Fujimoto
authors: Shiomi
authors: S
authors: Ishigo
authors: Hirokazu
authors: H
authors: Gotoh
authors: Osamu
authors: O
authors: Watanabe
authors: Tetsuya
authors: T
authors: Yagi
authors: Nami
authors: N
authors: Shimaoka
authors: Hiroshige
authors: H
authors: Mikamo
authors: Yuka
authors: Y
authors: Yamagishi
authors: Naohisa
authors: N
authors: Fujita
authors: Toshiaki
authors: T
authors: Komori
authors: Satoshi
authors: S
authors: Ichiyama
authors: Seiji
authors: S
authors: Kawano
authors: Akifumi
authors: A
authors: Nakayama
authors: Fumihiko
authors: F
authors: Nakamura
authors: Hisashi
authors: H
authors: Kohno
authors: Saori
authors: S
authors: Fukuda
authors: Nobuchika
authors: N
authors: Kusano
authors: Motoko
authors: M
authors: Nose
authors: Michiya
authors: M
authors: Yokozaki
authors: Makoto
authors: M
authors: Onodera
authors: Koji
authors: K
authors: Murao
authors: Kiyoshi
authors: K
authors: Negayama
authors: Tatsuya
authors: T
authors: Nishimiya
authors: Hitoshi
authors: H
authors: Miyamoto
authors: Akira
authors: A
authors: Matsunaga
authors: Hisae
authors: H
authors: Yoshimura
authors: Shigeru
authors: S
authors: Kohno
authors: Katsunori
authors: K
authors: Yanagihara
authors: Kazufumi
authors: K
authors: Hiramatsu
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D024881:Drug Resistance, Bacterial; D006801:Humans; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D013845:Thienamycins / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D013845:Thienamycins; D000077731:Meropenem