title: Computational design of protein therapeutics.
abstract: Computation is increasingly used to guide protein therapeutic designs. Some of the potential applications for computational, structure-based protein design include antibody affinity maturation, modulation of protein-protein interaction, stability improvement and minimization of protein aggregation. The versatility of a computational approach is that different biophysical properties can be analyzed on a common framework. Developing a coherent strategy to address various protein engineering objectives will promote synergy and exploration. Advances in computational structural analysis will thus have a transformative impact on how protein therapeutics are engineered in the future.:
authors: Department of Chemical and Biological Engineering, University at Buffalo, SUNY, Buffalo, NY, 14260, USA.
authors: Inseong
authors: I
authors: Hwang
authors: Department of Chemical and Biological Engineering, University at Buffalo, SUNY, Buffalo, NY, 14260, USA. Electronic address:sjpark6@buffalo.edu.
authors: Sheldon
authors: S
authors: Park