title: Bone and fat: a relationship of different shades.
abstract: Environmental and behavioral changes which occurred over the last century led simultaneously to a remarkable increase in human lifespan and to the development of health problems associated with functional impairment of organs either regulating or dependent on balanced energy metabolism. Diseases such as diabetes, obesity and osteoporosis are prevalent in our society and pose major challenges with respect to the overall health and economy. Therefore, better understanding of regulatory axes between bone and fat may provide the basis for development of strategies which will treat these diseases simultaneously and improve health and life quality of elderly.
authors: Department of Orthopaedic Surgery, University of Toledo Health Science Campus, Toledo, OH 43614, United States; Department of Physiology and Pharmacology, University of Toledo Health Science Campus, Toledo, OH 43614, United States; Center for Diabetes and Endocrine Research, University of Toledo Health Science Campus, Toledo, OH 43614, United States. Electronic address: beata.leckaczernik@utoledo.edu.
authors: Beata
authors: B
authors: Lecka-Czernik
authors: Department of Orthopaedic Surgery, University of Toledo Health Science Campus, Toledo, OH 43614, United States; Center for Diabetes and Endocrine Research, University of Toledo Health Science Campus, Toledo, OH 43614, United States.
authors: Lance A
authors: LA
authors: Stechschulte
mesh_terms: D000273:Adipose Tissue / Q000166:cytology / Q000502:physiology*; D000818:Animals; D016723:Bone Remodeling / Q000502:physiology*; D001842:Bone and Bones / Q000166:cytology / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D008954:Models, Biological
keywords: Adipocyte; BAT; Beige adipocytes; Bone marrow; Bone remodeling; Energy homeostasis; WAT