title: Multivalent glycosylated nanoparticles for studying carbohydrate-protein interactions.
abstract: Carbohydrates are essential mediators of many important extracellular binding events. Multivalent effects are often required for these binding interactions that are generally weak. Biologically significant carbohydrate-modified nanomaterials are an appealing model system for a systematic investigation of multivalent binding effects. This review seeks to highlight recent striking examples of multivalent glycosylated nanomaterials concentrating on carbohydrate-protein interactions. The specific aim is to provide an overview of various aspects of glyco-nanoparticles in binding assays, targeted therapy, molecular imaging, enzyme activity assay, and bacterium detection.
authors: Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan. cclin66@mx.nthu.edu.tw.
authors: Avijit K
authors: AK
authors: Adak
authors: Hong-Jyune
authors: HJ
authors: Lin
authors: Chun-Cheng
authors: CC
authors: Lin
mesh_terms: D002241:Carbohydrates / Q000737:chemistry*; D016503:Drug Delivery Systems; D006031:Glycosylation; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D011485:Protein Binding; D011506:Proteins / Q000378:metabolism*
chemical_list: D002241:Carbohydrates; D011506:Proteins