title: Low signal intensity in U-fiber identified by susceptibility-weighted imaging in two cases of progressive multifocal leukoencephalopathy.
abstract: Magnetic resonance imaging (MRI) is a useful tool for diagnosing and monitoring progressive multifocal leukoencephalopathy (PML). Although characteristic MRI findings of PML are well known, we noted a potential new finding for this disease on susceptibility-weighted imaging (SWI). Two patients with PML were studied and followed using MRI. SWI revealed low signal intensities in U-fibers adjacent to the white matter lesions of PML. These findings progressed along with the disease progression. The cause underlying these findings remains unclear. This new finding suggests that SWI is useful for the diagnosis of PML. It can provide a helpful clue in a clinical setting.
authors: Department of Radiology, Mie University School of Medicine, Japan.
authors: Mai
authors: M
authors: Miyagawa
authors: Department of Radiology, Mie University School of Medicine, Japan. Electronic address: mmaeda@clin.medic.mie-u.ac.jp.
authors: Masayuki
authors: M
authors: Maeda
authors: Department of Radiology, Mie University School of Medicine, Japan.
authors: Maki
authors: M
authors: Umino
authors: Department of Neurology, Mie University School of Medicine, Japan.
authors: Ken
authors: K
authors: Kagawa
authors: Department of Virology 1, National Institute of Infectious Diseases, Japan.
authors: Kazuo
authors: K
authors: Nakamichi
authors: Department of Radiology, Mie University School of Medicine, Japan.
authors: Hajime
authors: H
authors: Sakuma
authors: Department of Neurology, Mie University School of Medicine, Japan.
authors: Hidekazu
authors: H
authors: Tomimoto
mesh_terms: D000368:Aged; D038524:Diffusion Magnetic Resonance Imaging; D004198:Disease Susceptibility / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000150:complications; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications; D007968:Leukoencephalopathy, Progressive Multifocal / Q000209:etiology / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D066127:White Matter / Q000473:pathology
keywords: MRI; Progressive multifocal leukoencephalopathy; Susceptibility-weighted imaging; U-fiber