title: Loddigesiinols G-J: α-glucosidase inhibitors from Dendrobium loddigesii.
abstract: Four new polyphenols, loddigesiinols G-J (compounds 1-4) and a known compound, crepidatuol B (5), were isolated from the stems of Dendrobium loddigesii that have long been used in Traditional Chinese Medicine and have recently been used to treat type 2 diabetes. Compounds 1-5 structures were elucidated based on spectroscopic analysis. The absolute configurations of compounds 1-4 were determined using theoretical calculations of electronic circular dichroism (ECD), and the absolute configuration of compound 5 was determined by a comparison of the experimental ECD spectra and the literature data. Compounds 1-5 are strong inhibitors of α-glucosidase, with IC50 values of 16.7, 10.9, 2.7, 3.2, and 18.9 μM, respectively. Their activities were significantly stronger than trans-resveratrol as a positive control (IC50 values of 27.9 μM).
authors: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. luyu0626@sina.com.
authors: Yu
authors: Y
authors: Lu
authors: Guangdong Pharmaceutical University, Guangzhou 510006, China. kuangm55555@gmail.com.
authors: Ming
authors: M
authors: Kuang
authors: School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China. huguping@mail.sysu.edu.cn.
authors: Gu-Ping
authors: GP
authors: Hu
authors: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. wurb3@mail.sysu.edu.cn.
authors: Rui-Bo
authors: RB
authors: Wu
authors: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. wjun@mail.sysu.edu.cn.
authors: Jun
authors: J
authors: Wang
authors: School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China. cesllan@mail.sysu.edu.cn.
authors: Lan
authors: L
authors: Liu
authors: School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China. ceslyc@mail.sysu.edu.cn.
authors: Yong-Cheng
authors: YC
authors: Lin
mesh_terms: D031667:Dendrobium / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry / Q000302:isolation & purification*; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D010616:Phenanthrenes / Q000737:chemistry / Q000302:isolation & purification*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D018547:Plant Stems / Q000378:metabolism; D059808:Polyphenols / Q000737:chemistry / Q000302:isolation & purification*; D000520:alpha-Glucosidases / Q000737:chemistry
chemical_list: D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D010616:Phenanthrenes; D010936:Plant Extracts; D059808:Polyphenols; D000520:alpha-Glucosidases