title: A case of Liddle's syndrome; unusual presentation with hypertensive encephalopathy.
abstract: Liddle's syndrome is a rare cause of secondary hypertension. Identification of this disorder is important because treatment differs from other forms of hypertension. We report an interesting case of a 35-year-old lady, a known diabetic and hypertensive patient, who presented with features of hypertensive encephalopathy. The family history was unremarkable. Past treatment with various combinations of antihypertensive medications including spironolactone, all at high doses, failed to control her blood pressure. Upon evaluation, the patient had hypokalemic alkalosis, low 24-h urine potassium and suppressed plasma renin activity. Although these findings were similar to hyperaldosteronism, plasma aldosterone was lower than the normal range. Blood pressure decreased markedly after administration of amiloride. Along with hyporeninemic hypo-aldosteronism, the non-responsiveness to spironolactone and good response to amiloride established the diagnosis of Liddle's syndrome.
authors: Department of Endocrinology, Medwin Hospital, Hyderabad, India.
authors: Sunil Kumar
authors: SK
authors: Kota
authors: Siva Krishna
authors: SK
authors: Kota
authors: Sandip
authors: S
authors: Panda
authors: Kirtikumar D
authors: KD
authors: Modi
mesh_terms: D000328:Adult; D000584:Amiloride / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D004232:Diuretics / Q000627:therapeutic use; D005260:Female; D006801:Humans; D020343:Hypertensive Encephalopathy / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D056929:Liddle Syndrome / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D004232:Diuretics; D000584:Amiloride