title: Expression of small glutamine-rich TPR-containing protein A (SGTA) in Non-Hodgkin's Lymphomas promotes tumor proliferation and reverses cell adhesion-mediated drug resistance (CAM-DR).
abstract: The expression and biologic function of SGTA in Non-Hodgkin's Lymphomas (NHL) was investigated in this study. Clinically, by immunohistochemistry analysis we detected SGTA expression in both reactive lymphoid tissues and NHL tissues. In addition, we also correlated high expression of SGTA with poor prognosis. Functionally, SGTA expression was positively related with cell proliferation and negative related with cell adhesion. Finally, SGTA knockdown induced adhesion-mediated drug resistance. Our finding supports a role of SGTA in NHL cell proliferation, adhesion and drug resistance, and it may pave the way for a novel therapeutic approach for CAM-DR in NHL.
authors: Department of Pathology, Affiliated Cancer Hospital of Nantong University, Nantong 226361, Jiangsu, China.
authors: Yuchan
authors: Y
authors: Wang
authors: Department of Pathology, Medical College, Nantong University, Nantong 226001, Jiangsu, China.
authors: Yuejiao
authors: Y
authors: Huang
authors: Department of Pathology, Affiliated Cancer Hospital of Nantong University, Nantong 226361, Jiangsu, China.
authors: Xiaohong
authors: X
authors: Xu
authors: Department of Pathology, Medical College, Nantong University, Nantong 226001, Jiangsu, China.
authors: Jie
authors: J
authors: Tang
authors: Department of Pathology, Medical College, Nantong University, Nantong 226001, Jiangsu, China.
authors: Xianting
authors: X
authors: Huang
authors: Department of Pathology, Medical College, Nantong University, Nantong 226001, Jiangsu, China.
authors: Junya
authors: J
authors: Zhu
authors: Department of Pathology, Medical College, Nantong University, Nantong 226001, Jiangsu, China.
authors: Jing
authors: J
authors: Liu
authors: Department of Pathology, Affiliated Cancer Hospital of Nantong University, Nantong 226361, Jiangsu, China.
authors: Xiaobing
authors: X
authors: Miao
authors: Department of Pathology, Affiliated Cancer Hospital of Nantong University, Nantong 226361, Jiangsu, China.
authors: Yaxun
authors: Y
authors: Wu
authors: Department of Pediatrics, Medical College, Nantong University, Nantong 226001, Jiangsu, China.
authors: Fan
authors: F
authors: Yang
authors: Department of Pathology, Medical College, Nantong University, Nantong 226001, Jiangsu, China. Electronic address: liliji79@ntu.edu.cn.
authors: Lili
authors: L
authors: Ji
authors: Department of Pathology, Affiliated Cancer Hospital of Nantong University, Nantong 226361, Jiangsu, China. Electronic address: hesong2009@126.com.
authors: Song
authors: S
authors: He
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D002448:Cell Adhesion / Q000187:drug effects / Q000235:genetics; D049109:Cell Proliferation / Q000187:drug effects; D019008:Drug Resistance, Neoplasm / Q000187:drug effects / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D055785:Gene Knockdown Techniques; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D018832:Molecular Chaperones; D034741:RNA, Small Interfering / Q000235:genetics; D014407:Tumor Cells, Cultured
chemical_list: D014408:Biomarkers, Tumor; D002352:Carrier Proteins; D018832:Molecular Chaperones; D034741:RNA, Small Interfering; C114575:SGTA protein, human
keywords: Cell adhesion; Drug resistance; Non-Hodgkin's Lymphomas (NHL); Proliferation; SGTA