title: Oncologic efficacy of angiolytic KTP laser treatment of early glottic cancer.
abstract: OBJECTIVE
  Angiolytic laser removal of early glottic cancer with ultra-narrow margins was reported in a pilot study 5 years ago as an innovative surgical treatment strategy to better preserve vocal function. Subsequently, in a cohort of > 90 patients, enhanced voice outcomes were achieved and there was diminished need for post-treatment phonosurgical reconstruction. However, the initial pilot study examining oncologic efficacy had a limited number of patients and most did not have 3-year follow-up. Consequently, further analysis of the oncologic efficacy is valuable.
  
  
  METHODS
  Retrospective review.
  
  
  RESULTS
  One hundred seventeen patients (T1a-71, T1b-11, T2a-10, T2b-25) underwent potassium-titanyl-phosphate (KTP) laser treatment of early glottic cancer with a minimum 3-year follow-up (average = 53 months). The "b" designation delineated bilateral disease. Disease control for T1 and T2 lesions was 96% (79/82) and 80% (28/35), respectively. All 10 recurrences were treated with radiotherapy. Fifty percent (5/10) were controlled with radiotherapy, and the other 5 died of disease. Larynx preservation and survival were achieved in 99% (81/82) with T1 disease and 89% (31/35) with T2 disease.
  
  
  CONCLUSIONS
  This investigation provides further evidence that angiolytic KTP laser removal of early glottic cancer with ultra-narrow margins is an effective oncologic treatment strategy. Radiotherapy was preserved for future use in more than 90% of patients. Since a majority of patients are referred by an otolaryngologist to undergo treatment of early glottic cancer with radiotherapy, this investigation provides compelling information to reappraise this paradigm.
authors: Department of Surgery, Harvard Medical School; Center for Laryngeal Surgery and Voice Rehabilitation, Massachusetts General Hospital, Boston, Massachusetts, USA zeitels.steven@mgh.harvard.edu.
authors: Steven M
authors: SM
authors: Zeitels
authors: Department of Surgery, Harvard Medical School; Center for Laryngeal Surgery and Voice Rehabilitation, Massachusetts General Hospital, Boston, Massachusetts, USA.
authors: James A
authors: JA
authors: Burns
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery*; D005931:Glottis / Q000601:surgery*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000601:surgery*; D007828:Laryngoscopy; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D008866:Microsurgery / Q000379:methods*; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy; D009367:Neoplasm Staging; D010710:Phosphates; D012189:Retrospective Studies; D014025:Titanium; D014833:Voice Quality
chemical_list: D010710:Phosphates; C064806:potassium titanylphosphate; D014025:Titanium
keywords: KTP laser; glottic cancer; phonomicrosurgery; vocal cord cancer; vocal fold cancer; voice preservation; voice surgery