title: Deviant dynamics of EEG resting state pattern in 22q11.2 deletion syndrome adolescents: A vulnerability marker of schizophrenia?
abstract: Previous studies have repeatedly found altered temporal characteristics of EEG microstates in schizophrenia. The aim of the present study was to investigate whether adolescents affected by the 22q11.2 deletion syndrome (22q11DS), known to have a 30 fold increased risk to develop schizophrenia, already show deviant EEG microstates. If this is the case, temporal alterations of EEG microstates in 22q11DS individuals could be considered as potential biomarkers for schizophrenia. We used high-density (204 channel) EEG to explore between-group microstate differences in 30 adolescents with 22q11DS and 28 age-matched controls. We found an increased presence of one microstate class (class C) in the 22q11DS adolescents with respect to controls that was associated with positive prodromal symptoms (hallucinations). A previous across-age study showed that the class C microstate was more present during adolescence and a combined EEG-fMRI study associated the class C microstate with the salience resting state network, a network known to be dysfunctional in schizophrenia. Therefore, the increased class C microstates could be indexing the increased risk of 22q11DS individuals to develop schizophrenia if confirmed by our ongoing longitudinal study comparing both the adult 22q11DS individuals with and without schizophrenia, as well as schizophrenic individuals with and without 22q11DS.
authors: Functional Brain Mapping Laboratory, Department of Fundamental Neuroscience, University of Geneva, Geneva, Switzerland. Electronic address: ioana.tomescu@unige.ch.
authors: Miralena I
authors: MI
authors: Tomescu
authors: Functional Brain Mapping Laboratory, Department of Fundamental Neuroscience, University of Geneva, Geneva, Switzerland.
authors: Tonia A
authors: TA
authors: Rihs
authors: Functional Brain Mapping Laboratory, Department of Fundamental Neuroscience, University of Geneva, Geneva, Switzerland.
authors: Robert
authors: R
authors: Becker
authors: Functional Brain Mapping Laboratory, Department of Fundamental Neuroscience, University of Geneva, Geneva, Switzerland.
authors: Juliane
authors: J
authors: Britz
authors: Functional Brain Mapping Laboratory, Department of Fundamental Neuroscience, University of Geneva, Geneva, Switzerland.
authors: Anna
authors: A
authors: Custo
authors: Functional Brain Mapping Laboratory, Department of Fundamental Neuroscience, University of Geneva, Geneva, Switzerland; Center for Biomedical Imaging (CIBM), Department of Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland.
authors: Frédéric
authors: F
authors: Grouiller
authors: Office Médico-Pédagogique Research Unit, Department of Psychiatry, University of Geneva School of Medicine, Geneva, Switzerland.
authors: Maude
authors: M
authors: Schneider
authors: Office Médico-Pédagogique Research Unit, Department of Psychiatry, University of Geneva School of Medicine, Geneva, Switzerland; Adolescent Clinical Psychology Research Unit, Faculty of Psychology, University of Geneva, Geneva, Switzerland.
authors: Martin
authors: M
authors: Debbané
authors: Office Médico-Pédagogique Research Unit, Department of Psychiatry, University of Geneva School of Medicine, Geneva, Switzerland.
authors: Stephan
authors: S
authors: Eliez
authors: Functional Brain Mapping Laboratory, Department of Fundamental Neuroscience, University of Geneva, Geneva, Switzerland.
authors: Christoph M
authors: CM
authors: Michel
mesh_terms: D000293:Adolescent; D015415:Biomarkers; D001921:Brain / Q000503:physiopathology*; D002648:Child; D004062:DiGeorge Syndrome / Q000503:physiopathology*; D004569:Electroencephalography; D058068:Endophenotypes; D005260:Female; D006212:Hallucinations / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000503:physiopathology; D062706:Prodromal Symptoms; D012559:Schizophrenia / Q000175:diagnosis* / Q000503:physiopathology; D035781:Siblings; D012815:Signal Processing, Computer-Assisted
chemical_list: D015415:Biomarkers
keywords: 22q11DS; EEG microstates; Endophenotype; Prodromal symptoms; VCFS