title: Selective serotonin reuptake inhibitor and bleeding in a cynomolgus macaque (Macaca fascicularis).
abstract: Selective serotonin reuptake inhibitors (SSRI) are associated with an increased bleeding risk in humans. This report describes a bleeding event in a cynomolgus macaque (Macaca fascicularis) treated with the SSRI sertraline HCl (Zoloft). During the treatment course, the subject presented with a maculopapular rash, cutaneous bleeding, epistaxis, bleeding from the eye, melena, and a severe thrombocytopenia. To our knowledge, this report is the first description of an SSRI-related adverse event in a nonhuman primate. This report demonstrates that the clinical presentation of SSRI-associated bleeding in cynomolgus macaques is consistent with that reported in humans and that complications from SSRI treatment should be considered as a differential diagnosis for maculopapular dermatitis or spontaneous bleeding in this species.
authors: Department of Pathology, Section on Comparative Medicine, Integrative Physiology and Pharmacology Graduate Program, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
authors: Marnie G
authors: MG
authors: Silverstein
authors: Department of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
authors: Colette Kirk
authors: CK
authors: El-Amin
authors: Department of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. cshively@wakehealth.edu.
authors: Carol A
authors: CA
authors: Shively
mesh_terms: D000818:Animals; D000830:Animals, Laboratory; D003863:Depression / Q000188:drug therapy; D006470:Hemorrhage / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*; D008252:Macaca fascicularis; D008992:Monkey Diseases / Q000139:chemically induced* / Q000473:pathology*; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*; D020280:Sertraline / Q000009:adverse effects*; D013921:Thrombocytopenia / Q000139:chemically induced / Q000473:pathology
chemical_list: D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline