title: Candida antigens and immune responses: implications for a vaccine.
abstract: Superficial candidiasis of the oral cavity, vagina and the skin are common mild infections though they may be recalcitrant, as in the case of recurrent vaginitis or denture stomatitis. However, in debilitated people with immune deficiencies, Candida can cause serious invasive infections with high mortality. Both types of patients could benefit from the development of vaccines and monoclonal or polyclonal antibodies of utility for a passive immunization, according to their immune status. Several antigens as mannans, β-glucans, various adhesins, heat shock protein 90 and acid secreted proteinases can be very useful for the vaccines development. There is a broad and sound experience with many of these antigens in animal models, mainly in rabbits and mice. However, only two vaccines, based on recombinant antigens (rAls3p-N and rSap2t) are currently being tested in clinical trials.
authors: Department of Enfermería 1, Universidad del País Vasco UPV/EHU, Bilbao, Spain.
authors: Maria Dolores
authors: MD
authors: Moragues
authors: Aitor
authors: A
authors: Rementeria
authors: María Jesús
authors: MJ
authors: Sevilla
authors: Elena
authors: E
authors: Eraso
authors: Guillermo
authors: G
authors: Quindos
mesh_terms: D000818:Animals; D000946:Antigens, Fungal / Q000276:immunology*; D002175:Candida / Q000276:immunology*; D002177:Candidiasis / Q000276:immunology / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D005657:Fungal Vaccines / Q000276:immunology* / Q000302:isolation & purification*; D006801:Humans; D051379:Mice; D011817:Rabbits; D014614:Vaccines, Synthetic / Q000276:immunology / Q000302:isolation & purification
chemical_list: D000946:Antigens, Fungal; D005657:Fungal Vaccines; D014614:Vaccines, Synthetic
keywords: Candida albicans; Hsp90; betaglucan; candidiasis; mannan; monoclonal antibody; rAls3p-N; rHyr1p; rSap2t; vaccine