title: Evaluation of urinary enzymes in newborns treated with gentamicin.
abstract: OBJECTIVE
  In recent years, there has been an increasing amount of study on early diagnosis of kidney injury through sensitive and specific biomarkers. We examined the practical applicability of the urinary levels of NAG (N-acetyl-β-D-glucosaminidase), AP (alkaline phosphatase), and LDH (lactate dehydrogenase) as renal dysfunction screening biomarkers in full and pre-term newborns treated with gentamicin.
  
  
  METHODS
  Fourteen pre-term and fifteen full-term newborns who received gentamicin for suspected infections were enrolled. Serum and urine specimens were obtained before the zero days and after gentamicin infusion on the 1st, 3rd, and 5th days of treatment.
  
  
  RESULTS
  In full-term newborns a significant increase in urinary NAG, LDH, AP after 5 days of gentamicin administration compared with control group was noted (P<0.05, P<0.001 and P<0.01; respectively).
  
  
  CONCLUSIONS
  Our findings indicate that urinary enzymes may be useful in full-term newborns as a non-invasive method for evaluation of tubular function.
authors: Alborz Hospital, Social Security Organization, Karaj, Iran ; Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.
authors: Ali Mohammadi
authors: AM
authors: Karakani
authors: Alborz Hospital, Social Security Organization, Karaj, Iran.
authors: Solmaz Asgharzadeh
authors: SA
authors: Haghighi
authors: Departments of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors: Mahmoud
authors: M
authors: Ghazi-Khansari
authors: Alborz Hospital, Social Security Organization, Karaj, Iran.
authors: Afsaneh
authors: A
authors: Seyed-Ebrahimi
authors: Nursing and Midwifery, Islamic Azad University of Karaj, Iran.
authors: Sharareh
authors: S
authors: Zeighami-Mohammadi
keywords: Biomarker; Gentamicin; Newborn; Urine