title: Role of miR-15/16 in CLL.
abstract: B-cell chronic lymphocytic leukemia (CLL) is the most common adult leukemia. The most common chromosomal abnormalities detectable by cytogenetics include deletion at 13q (55%), 11q (18%), trisomy 12 (12-16%) and 17p (8%). In 2002, we discovered that a microRNA cluster miR-15a/miR-16-1 (miR-15/16) is the target of 13q deletions in CLL. MicroRNAs encoded by the miR-15/16 locus (miR-15 and miR-16) function as tumor suppressors. Expression of these miRNAs downregulated in CLL, melanoma, colorectal cancer, bladder cancer and other solid tumors. miR-15/16 cluster targets multiple oncogenes, including BCL2, Cyclin D1, MCL1 and others. The most important target of miR-15/16 in CLL is arguably BCL2, as BCL2 is overexpressed in almost all CLLs. In this review, we discuss the discovery, functions, clinical relevance and treatment opportunities related to miR-15/16.
authors: Department of Molecular Virology, Immunology and Medical Genetics, the Wexner Medical Center, Columbus, OH, USA.
authors: Y
authors: Y
authors: Pekarsky
authors: Department of Molecular Virology, Immunology and Medical Genetics, the Wexner Medical Center, Columbus, OH, USA.
authors: C M
authors: CM
authors: Croce
mesh_terms: D000328:Adult; D000818:Animals; D002869:Chromosome Aberrations; D015536:Down-Regulation / Q000235:genetics; D015973:Gene Expression Regulation, Leukemic; D016147:Genes, Tumor Suppressor; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D005810:Multigene Family; D015513:Oncogene Proteins / Q000096:biosynthesis; D012334:RNA, Neoplasm / Q000235:genetics / Q000378:metabolism
chemical_list: C505361:MIRN15 microRNA, human; C505362:MIRN16 microRNA, human; D035683:MicroRNAs; D015513:Oncogene Proteins; D012334:RNA, Neoplasm