title: One-step synthesis of diazaspiro[4.5]decane scaffolds with exocyclic double bonds.
abstract: Unactivated yne-en-ynes reacted with a range of substituted aryl halides in the presence of Pd(OAc)2-PPh3 to afford diazaspiro[4.5]decane with exocyclic double bonds. Three carbon-carbon bonds are formed in this domino reaction, which involves highly regioselective C-C coupling and spiro scaffold steps.
authors: Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Key Laboratory of Molecular-Based Materials, School of Chemistry and Materials Science, Anhui Normal University, Wuhu, Anhui 241000, China. yiminhu@mail.ahnu.edu.cn.
authors: Lidong
authors: L
authors: Li
authors: Qiong
authors: Q
authors: Hu
authors: Pingping
authors: P
authors: Zhou
authors: Haifeng
authors: H
authors: Xie
authors: Xiaorong
authors: X
authors: Zhang
authors: Hao
authors: H
authors: Zhang
authors: Yadong
authors: Y
authors: Hu
authors: Fei
authors: F
authors: Yin
authors: Yimin
authors: Y
authors: Hu
mesh_terms: D000473:Alkanes / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D002845:Chromatography; D008968:Molecular Conformation; D010165:Palladium / Q000737:chemistry*; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000473:Alkanes; D013141:Spiro Compounds; D010165:Palladium; C012867:decane