title: Medicinal chemistry discoveries among 1,3,5-triazines: recent advances (2000-2013) as antimicrobial, anti-TB, anti-HIV and antimalarials.
abstract: The chemistry and an extensive spectrum of biological activities of s-triazines have been examined since several decades and this heterocyclic core has received emerging consensus. This article aims to summarize recent advances (2000-2013) made towards the discovery of antimicrobial, antituberculosis, anti-HIV and antimalarial agents holding 1,3,5-triazine ring as a nucleus with the substitution of several types of nucleophiles. Molecular patterns associated with particular potency have been identified targeting several Gram-positive and Gram-negative bacteria and some fungal species, mycobacterium tuberculosis H37Rv, HIV type I and HIV type II, particularly, HIV-1I IIB and HIV- 1ROD strains as well as a variety of P. falciparum malarial strains as chloroquine-resistant K1, chloroquine-susceptible NF54, chloroquine-sensitive 3D7, P. falciparum (D6 clone), P. falciparum (W2 clone), cycloguanil-resistant FCR-3, chloroquine sensitive RKL2. The report will be of considerable interest to gain useful information for the furtherance of drug discovery with extended 1,3,5-triazine designs.
authors: Rahul V
authors: RV
authors: Patel
authors: Young-Soo
authors: YS
authors: Keum
authors: Organic Research Laboratory, Department of Bioresources and Food Science, College of Life and Environmental Sciences, Konkuk University, Seoul- 143 701, South Korea. sewpark@konkuk.ac.kr.
authors: Se Won
authors: SW
authors: Park
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D055808:Drug Discovery; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000469:parasitology; D009181:Mycoses / Q000188:drug therapy / Q000382:microbiology; D014227:Triazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use
chemical_list: D019380:Anti-HIV Agents; D000890:Anti-Infective Agents; D000962:Antimalarials; D000995:Antitubercular Agents; D014227:Triazines