title: [Determination of fatty acid esters of chloropropanediols in diet samples by gas chromatography-mass spectrometry coupled with solid-supported liquid-liquid extraction].
abstract: OBJECTIVE
  To establish a method for the determination of fatty acid esters of 3-monochloropropane-1, 2-diol (3-MCPD) and 2-monochloropropane-1, 3-diol (2-MCPD) in diet samples by gas chromatography-mass spectrometry (GC-MS) with solid-supported liquid-liquid extraction (SLE).
  
  
  METHODS
  Diet samples were ultrasonically extracted by hexane, followed by ester cleavage reaction with sodium methylate in methanol, and then purified by solid-supported liquid-liquid extraction. (SLE) using diatomaceous earth as the sorbent. After derivatization with heptafluorobutyrylimidazole, the analytes were detected by GC-MS and quantified by the deuterated internal standards.
  
  
  RESULTS
  The limits of detection (LODs) of 3-MCPD esters and 2-MCPD esters in different diet samples were 0.002 - 0.005 mg/kg and 0.002 - 0.006 mg/kg. The average recoveries of 3-MCPD esters and 2-MCPD esters at the spiking levels of 0.05 and 0.1 mg/kg in the diet samples were in the range of 65.9% - 104.2% and 75.4% - 118.0%, respectively, with the relative standard deviations in the range of 2.2% - 14.2% and 0.8% - .13.9%.
  
  
  CONCLUSIONS
  The method is simple, accurate and rugged for the determination of fatty acid esters of 3-MCPD and 2-MCPD in diet samples.
authors: Jie
authors: J
authors: Gao
authors: Qing
authors: Q
authors: Liu
authors: Feng
authors: F
authors: Han
authors: Hong
authors: H
authors: Miao
authors: Yunfeng
authors: Y
authors: Zhao
authors: Yongning
authors: Y
authors: Wu
mesh_terms: D004032:Diet; D004952:Esters; D005227:Fatty Acids / Q000032:analysis*; D005502:Food; D005504:Food Analysis; D008401:Gas Chromatography-Mass Spectrometry; D059625:Liquid-Liquid Extraction; D000517:alpha-Chlorohydrin
chemical_list: D004952:Esters; D005227:Fatty Acids; D000517:alpha-Chlorohydrin