title: Efficacy of glycerol and flax seed oil as anti-adhesive barriers after thyroidectomy.
abstract: BACKGROUND
  We evaluated the effects of local flax seed oil and glycerol application for reducing adhesion formation after thyroidectomy.
  
  
  METHODS
  We randomly assigned 18 female Wistar albino rats (median weight: 275 g, median age: 4.5 mth) to 3 groups: 0.1 ml 0.9% NaCl, glycerol, and flax seed oil were sprayed in a perithyroidal area after thyroidectomy operation on all animals as anti-adhesive barriers. Rats were sacrificed on the postoperative 14th day and adhesions were evaluated macroscopically and microscopically.
  
  
  RESULTS
  The median macroscopic adhesion score was 3.0±0.0 in the 0.9% NaCl group, 1.33±0.52 in the glycerol group, and 1.67±0.53 in the flax seed oil group. The median histopathological fibrosis scores were 2.33±0.82, 0.67±0.52, and 0.83±0.75, respectively. Both glycerol and flaxseed oil group macroscopic and microscopic scores were significantly lower than the 0.9% NaCl group (p<0.05). There was no significant difference among the groups (p>0.05).
  
  
  CONCLUSIONS
  Glycerol and flax seed oil both decrease the incidence of post-thyroidectomy adhesion in rats, but glycerol is more effective.
authors: Department of General Surgery, Bezmialem University, İstanbul, Turkey.
authors: Oguz
authors: O
authors: Idiz
authors: Department of General Surgery, Bezmialem University, İstanbul, Turkey.
authors: Erhan
authors: E
authors: Aysan
authors: Department of General Surgery, Erzincan University, Erzincan, Turkey.
authors: Deniz
authors: D
authors: Firat
authors: Department of General Surgery, Bezmialem University, İstanbul, Turkey.
authors: Yeliz Emine
authors: YE
authors: Ersoy
authors: Department of General Surgery, Bezmialem University, İstanbul, Turkey.
authors: Merve Busra
authors: MB
authors: Cengiz
authors: Department of General Surgery, Bezmialem University, İstanbul, Turkey.
authors: Huseyin
authors: H
authors: Akbulut
authors: Department of General Surgery, Erzincan University, Erzincan, Turkey.
authors: Arda
authors: A
authors: Isık
authors: Department of General Surgery, Bezmialem University, İstanbul, Turkey.
authors: Mahmut
authors: M
authors: Muslumanoglu
mesh_terms: D000818:Animals; D005260:Female; D005355:Fibrosis; D005990:Glycerol / Q000627:therapeutic use*; D008043:Linseed Oil / Q000627:therapeutic use*; D017208:Rats, Wistar; D013965:Thyroidectomy / Q000009:adverse effects*; D000267:Tissue Adhesions / Q000188:drug therapy* / Q000209:etiology*
chemical_list: D008043:Linseed Oil; D005990:Glycerol