title: Application of gas chromatography-mass spectrometry in analyzing pharmacokinetics and distribution of deltamethrin in miniature pig tissues.
abstract: OBJECTIVE
  To characterize the pharmacokinetics and distribution profiles of deltamethrin in miniature pig tissues by gas chromatography-mass spectrometry (GC-MS).
  
  
  METHODS
  Pharmacokinetics and distribution of deltamethrin in blood and tissues of 30 miniature pigs were studied by GC-MS after oral administration of deltamethrin (5 mg/kg bw). Data were processed by 3P97 software.
  
  
  RESULTS
  The serum deltamethrin level was significantly lower in tissues than in blood of miniature pigs. The AUC0-72 h, Cmax, of deltamethrin were 555.330 ± 316.987 ng h/mL and 17.861 ± 11.129 ng/mL, respectively. The Tmax, of deltamethrin was 6.004 ± 3.131 h.
  
  
  CONCLUSIONS
  The metabolism of deltamethrin in miniature pigs is fit for a one-compartment model with a weighting function of 1/C2. Deltamethrin is rapidly hydrolyzed and accumulated in miniature pig tissues.
authors: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi, China; Key Laboratory of Food Safety Risk Assessment of Ministry of Health, China National Center for Food Safety Risk Assessment, Beijing 100021, China.
authors: Pan
authors: P
authors: Zhu
authors: Institute of Nutrition and Food Safety, Beijing Centre of Disease Control and Prevention, Beijing 100013, China.
authors: Sai
authors: S
authors: Fan
authors: The Second Artillery General Hospital, Beijing 100088, China.
authors: Jian Hong
authors: JH
authors: Zou
authors: Key Laboratory of Food Safety Risk Assessment of Ministry of Health, China National Center for Food Safety Risk Assessment, Beijing 100021, China.
authors: Hong
authors: H
authors: Miao
authors: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi, China; Key Laboratory of Food Safety Risk Assessment of Ministry of Health, China National Center for Food Safety Risk Assessment, Beijing 100021, China.
authors: Jing Guang
authors: JG
authors: Li
authors: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi, China.
authors: Guo Wen
authors: GW
authors: Zhang
authors: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi, China; Key Laboratory of Food Safety Risk Assessment of Ministry of Health, China National Center for Food Safety Risk Assessment, Beijing 100021, China.
authors: Yong Ning
authors: YN
authors: Wu
mesh_terms: D000042:Absorption; D000818:Animals; D008401:Gas Chromatography-Mass Spectrometry; D023421:Models, Animal; D009570:Nitriles / Q000493:pharmacokinetics*; D011722:Pyrethrins / Q000493:pharmacokinetics*; D013552:Swine; D013556:Swine, Miniature; D014018:Tissue Distribution
chemical_list: D009570:Nitriles; D011722:Pyrethrins; C017180:decamethrin
keywords: Deltamethrin; GC-MS; Miniature pig; Pharmacokinetics; Tissue distribution