title: Comparison of continuous subcutaneous insulin infusion and multiple daily insulin injections in Chinese patients with type 2 diabetes mellitus.
abstract: OBJECTIVE
  To investigate prospectively the insulin dose requirements of Chinese patients with type 2 diabetes mellitus treated with either multiple daily insulin injections (MDI) or continuous subcutaneous insulin infusion (CSII) therapy during a 2-week therapeutic intervention.
  
  
  METHODS
  Patients with type 2 diabetes mellitus were randomly assigned to MDI or CSII therapy. The effects of the two treatment methods were determined based on blood glucose parameters, total daily insulin dose and rates of hypoglycaemia.
  
  
  RESULTS
  A total of 609 patients were enrolled in the study. Glycaemic goals were achieved after a mean ± SD of 6.90 ± 2.10 and 5.44 ± 2.22 days' treatment in the MDI and CSII groups, respectively. Once stabilized, the mean ± SD total daily insulin doses were 37.12 ± 10.19 IU and 32.58 ± 8.78 IU for the MDI and CSII groups, respectively. Once stabilized, the mean ± SD total basal and bolus doses were 19.46 ± 7.95 IU/day and 17.66 ± 3.53 IU/day for the MDI group, and 22.79 ± 7.55 IU/day and 9.81 ± 2.64 IU/day for the CSII group, respectively. There were significant differences in the total, basal and bolus insulin doses between the two groups.
  
  
  CONCLUSIONS
  CSII therapy may be considered as an effective method to achieve good glycaemic control in Chinese patients with type 2 diabetes mellitus.
authors: Department of Endocrinology, Yishui People's Hospital, Linyi, Shandong Province, China.
authors: Honghong
authors: H
authors: Yang
authors: Department of Clinical Medicine, Linyi People's Hospital, Linyi, Shandong Province, China.
authors: Xueyuan
authors: X
authors: Heng
authors: Department of Endocrinology, Linyi People's Hospital, Linyi, Shandong Province, China.
authors: Cuige
authors: C
authors: Liang
authors: Department of Endocrinology, Linyi People's Hospital, Linyi, Shandong Province, China.
authors: Xiaomeng
authors: X
authors: Liu
authors: Department of Endocrinology, Linyi People's Hospital, Linyi, Shandong Province, China.
authors: Wenhua
authors: W
authors: Du
authors: Department of Endocrinology, Yishui People's Hospital, Linyi, Shandong Province, China.
authors: Shoujie
authors: S
authors: Li
authors: Department of Endocrinology, Linyi People's Hospital, Linyi, Shandong Province, China.
authors: Yueli
authors: Y
authors: Wang
authors: Department of Endocrinology, Linyi People's Hospital, Linyi, Shandong Province, China.
authors: Qingyu
authors: Q
authors: Dong
authors: Department of Endocrinology, Linyi People's Hospital, Linyi, Shandong Province, China.
authors: Wenxia
authors: W
authors: Li
authors: Department of Internal Medicine, Shandong Medical College, Linyi, Shandong Province, China.
authors: Zhenyu
authors: Z
authors: Pan
authors: Department of Internal Medicine, Shandong Medical College, Linyi, Shandong Province, China.
authors: Qian
authors: Q
authors: Gong
authors: Department of Endocrinology, Linyi People's Hospital, Linyi, Shandong Province, China guanqigao@126.com.
authors: Guanqi
authors: G
authors: Gao
mesh_terms: D001786:Blood Glucose / Q000187:drug effects*; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000097:blood; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D055104:Infusions, Subcutaneous / Q000379:methods*; D007267:Injections / Q000379:methods*; D007328:Insulin / Q000008:administration & dosage* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin
keywords: Type 2 diabetes mellitus; continuous subcutaneous insulin infusion; multiple daily injections