title: Malignant myoepithelioma of the breast: a case report and review of literature.
abstract: In this article, we described a malignant myoepithelioma of the breast (MMB) in a 69-year-old woman. Breast cancer derived from myoepithelial cells is very rare, usually benign. The diagnosis of MMB based on histological and immunohistochemical finding. In this case, the author diagnosed the tumor as MMB, because tumor tissues were immunopositive for 34βE12, P63, SMA, S-100, CD10, E-Cad and Ki-67, and immunnegative for CK5/6, desmin, ER, PR and C-erbB-2, because tumor tissue showed invasive growth and local hemorrhage or necrosis, suggesting malignant, and also because there was a transition between the tumor cells and hyperplastic myoepithelium of non-tumorous ducts. The patient's postoperative recovery is smooth and regular following of patient is essential.
authors: Department of Pathology, Taiping People's Hospital of Dongguan Dongguan 523905, China ; Dongguan Hospital Affiliated to Medical College of Jinan University Dongguan, 523905, China.
authors: Yan-Fang
authors: YF
authors: Liang
authors: Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics Dongguan, 523808, China.
authors: Jin-Cheng
authors: JC
authors: Zeng
authors: Department of Pathology, Taiping People's Hospital of Dongguan Dongguan 523905, China ; Dongguan Hospital Affiliated to Medical College of Jinan University Dongguan, 523905, China.
authors: Jian-Bo
authors: JB
authors: Ruan
authors: Department of Pathology, Taiping People's Hospital of Dongguan Dongguan 523905, China ; Dongguan Hospital Affiliated to Medical College of Jinan University Dongguan, 523905, China.
authors: Dong-Ping
authors: DP
authors: Kang
authors: Department of Pathology, Taiping People's Hospital of Dongguan Dongguan 523905, China ; Dongguan Hospital Affiliated to Medical College of Jinan University Dongguan, 523905, China.
authors: Ling-Mei
authors: LM
authors: Wang
authors: Department of Pathology, Taiping People's Hospital of Dongguan Dongguan 523905, China ; Dongguan Hospital Affiliated to Medical College of Jinan University Dongguan, 523905, China.
authors: Can
authors: C
authors: Chen
authors: Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics Dongguan, 523808, China.
authors: Jun-Fa
authors: JF
authors: Xu
authors: Sun Yat-Sen University Cancer Center Guanzhou 510060, China.
authors: Qiu-Liang
authors: QL
authors: Wu
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D001943:Breast Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D006965:Hyperplasia; D007150:Immunohistochemistry; D015409:Mastectomy, Radical; D009208:Myoepithelioma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D009336:Necrosis; D009361:Neoplasm Invasiveness
chemical_list: D014408:Biomarkers, Tumor
keywords: Malignant myoepithelioma; breast; immunohistochemistry