title: Effect of diagnostic criteria on prevalence of frontotemporal dementia in the elderly.
abstract: BACKGROUND
  Frontotemporal dementia (FTD) is believed to be rare in the elderly, and the influence of different criteria on the prevalence of FTD is unclear.
  
  
  METHODS
  Population-based samples of 70- to 95-year-olds (n = 2462) in Gothenburg, Sweden, underwent neuropsychiatric examinations. Behavioral variant FTD (bvFTD) was diagnosed according to the International Behavioural Variant FTD Criteria Consortium (FTDC), the Frontotemporal Lobe Degeneration Consensus criteria, and the Lund-Manchester Research Criteria. A subset (n = 1074) underwent computerized tomography (CT) of the brain.
  
  
  RESULTS
  The prevalence of bvFTD varied between 0.2% and 0.5% at age 70 to 79 years, between 2.5% and 3.6% at age 80 to 89 years, and between 1.7% and 2.2% at age 90 to 95 years. The agreement between different criteria was low to moderate (κ = 0.20-0.42). Among those with bvFTD according to FTDC, 93.3% had frontal and/or temporal lobar atrophy on CT, compared with 12.6% of those without bvFTD (P < .001).
  
  
  CONCLUSIONS
  The prevalence of bvFTD was higher than expected in this population. To a large extent, different criteria captured different individuals.
authors: Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, The Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden. Electronic address: thorsteinn.gislason@neuro.gu.se.
authors: Thorsteinn B
authors: TB
authors: Gislason
authors: Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, The Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.
authors: Svante
authors: S
authors: Östling
authors: Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, The Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.
authors: Anne
authors: A
authors: Börjesson-Hanson
authors: Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, The Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.
authors: Magnus
authors: M
authors: Sjögren
authors: Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy.
authors: Michela
authors: M
authors: Simoni
authors: Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy.
authors: Leonardo
authors: L
authors: Pantoni
authors: Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, The Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.
authors: Ingmar
authors: I
authors: Skoog
mesh_terms: D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000000981:diagnostic imaging; D016009:Chi-Square Distribution; D016000:Cluster Analysis; D018672:Community Health Planning; D005260:Female; D057180:Frontotemporal Dementia / Q000175:diagnosis* / Q000453:epidemiology*; D006801:Humans; D008297:Male; D015995:Prevalence; D011569:Psychiatric Status Rating Scales / Q000592:standards*; D012189:Retrospective Studies; D017678:Sex Distribution; D013548:Sweden / Q000453:epidemiology; D014057:Tomography, X-Ray Computed
keywords: Aged; Frontotemporal dementia; Prevalence; Tomography; X-ray computed