title: Tranexamic acid reduces intraoperative blood loss in orthognathic surgery.
abstract: METHODS
  Medline, Embase and the reference lists of identified articles were also scanned for relevant papers.
  
  
  METHODS
  Only randomised controlled trials in English were considered.
  
  
  METHODS
  Two reviewers extracted data independently and study quality was assessed using the Jadad score. Meta-analysis was conducted.
  
  
  RESULTS
  Four RCTs with a total of 183 patients were included. Intraoperative blood loss in the tranexamic acid group was statistically reduced (weighted mean difference [WMD] = -93.56, 95% CI = -132.59-54.52, P < .00001). No statistical difference was seen in the postoperative levels of haemoglobin and haematocrit (WMD = 0.50, 95% CIs = -0.43-1.43, P = .29 and WMD = 0.18, 95% CIs = -1.64-1.99, P = .85, respectively).
  
  
  CONCLUSIONS
  This meta-analysis confirms that tranexamic acid can effectively reduce intraoperative blood loss in orthognathic surgery, especially by intravenous administration. But tranexamic acid cannot affect postoperative levels of haemoglobin and haematocrit.
authors: NYU College of Dentistry, New York, USA.
authors: Camelia
authors: C
authors: Espahbod
authors: NYU College of Dentistry, New York, USA.
authors: Analia
authors: A
authors: Veitz-Keenan
mesh_terms: D000933:Antifibrinolytic Agents / Q000627:therapeutic use*; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D006801:Humans; D056948:Orthognathic Surgical Procedures / Q000379:methods*; D016032:Randomized Controlled Trials as Topic; D014148:Tranexamic Acid / Q000627:therapeutic use*
chemical_list: D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid