title: Five New Guanacastane-Type Diterpenes from Cultures of the Fungus Psathyrella candolleana.
abstract: Five new guanacastane-type diterpenes, named guanacastepenes P-T (1-5), were isolated from cultures of the fungus Psathyrella candolleana. Their structures were elucidated on the basis of extensive spectroscopic methods. All of the compounds were tested for their 11β-hydroxysteroid dehydrogenase (11β-HSD1) inhibitory activity. Compound 3 exhibited inhibitory activity against both human and mouse isozymes of 11β-HSD1 with IC50 values of 6.2 and 13.9 μM, respectively.
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 People's Republic of China ; University of Chinese Academy of Sciences, Beijing, 100049 People's Republic of China.
authors: Xia
authors: X
authors: Yin
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 People's Republic of China.
authors: Tao
authors: T
authors: Feng
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 People's Republic of China.
authors: Zheng-Hui
authors: ZH
authors: Li
authors: Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203 People's Republic of China.
authors: Ying
authors: Y
authors: Leng
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 People's Republic of China.
authors: Ji-Kai
authors: JK
authors: Liu
keywords: 11β-HSD1; Guanacastepenes P–T; Psathyrella candolleana; Psathyrellaceae diterpenes