title: Biodegradable and elastomeric poly(glycerol sebacate) as a coating material for nitinol bare stent.
abstract: We synthesized and evaluated biodegradable and elastomeric polyesters (poly(glycerol sebacate) (PGS)) using polycondensation between glycerol and sebacic acid to form a cross-linked network structure without using exogenous catalysts. Synthesized materials possess good mechanical properties, elasticity, and surface erosion biodegradation behavior. The tensile strength of the PGS was as high as 0.28 ± 0.004 MPa, and Young's modulus was 0.122 ± 0.0003 MPa. Elongation was as high as 237.8 ± 0.64%, and repeated elongation behavior was also observed to at least three times the original length without rupture. The water-in-air contact angles of the PGS surfaces were about 60°. We also analyzed the properties of an electrospray coating of biodegradable PGS on a nitinol stent for the purpose of enhancing long-term patency for the therapeutic treatment of varicose veins disease. The surface morphology and thickness of coating layer could be controlled by adjusting the electrospraying conditions and solution parameters.
authors: Department of Polymer Science and Engineering, Sungkyunkwan University, Suwon 440746, Republic of Korea.
authors: Min Ji
authors: MJ
authors: Kim
authors: Department of Polymer Science and Engineering, Sungkyunkwan University, Suwon 440746, Republic of Korea.
authors: Moon Young
authors: MY
authors: Hwang
authors: School of Chemical Engineering, Sungkyunkwan University, Suwon 440746, Republic of Korea.
authors: JiHeung
authors: J
authors: Kim
authors: Department of Polymer Science and Engineering, Sungkyunkwan University, Suwon 440746, Republic of Korea.
authors: Dong June
authors: DJ
authors: Chung
mesh_terms: D000497:Alloys / Q000737:chemistry / Q000494:pharmacology; D063566:Biodegradable Plastics / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D003651:Decanoates / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D054855:Drug-Eluting Stents; D004548:Elasticity; D005990:Glycerol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D008422:Materials Testing; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D013718:Tensile Strength; D014648:Varicose Veins / Q000473:pathology / Q000628:therapy*
chemical_list: D000497:Alloys; D063566:Biodegradable Plastics; D003651:Decanoates; D011108:Polymers; C469892:poly(glycerol-sebacate); C013616:nitinol; D005990:Glycerol