title: Therapeutic effect of irradiation of magnetic infrared laser on osteoarthritis rat model.
abstract: Osteoarthritis (OA) is a degenerative joint disease caused by articular cartilage loss. Many complementary and alternative medicines for OA have been reported so far, but the effectiveness is controversial. Previously, we have shown anti-inflammatory effects of low level laser therapy with static magnetic field, magnetic infrared laser (MIL), in various animal models. Therefore, the beneficial effects were examined in OA rat model. Rats were divided by six groups; no treatment controls of sham and OA model, three MIL treatment groups of OA model at 6.65, 2.66 and 1.33 J cm(-2), and Diclofenac group of OA model with 2 mg kg(-1) diclofenac sodium. The OA control exhibited typical symptoms of OA, but 4-week MIL treatment improved the functional movement of knee joint with reduced edematous changes. In addition, cartilage GAGs were detected more in all MIL treatment groups than OA control. It suggests that 4-week MIL irradiation has dose-dependent anti-inflammatory and chondroprotective effects on OA. Histopathological analyses revealed that MIL treatment inhibits the cartilage degradation and enhances chondrocyte proliferation. The fact that MIL has an additional potential for the cartilage formation and no adverse effects can be regarded as great advantages for OA treatment. These suggest that MIL can be useful for OA treatment.
authors: Department of Oriental Rehabilitation Medicine, College of Korean Medicine, Daegu Haany University, Gyeongsan, Korea.
authors: Chul-Hwan
authors: CH
authors: Moon
authors: Ogon
authors: O
authors: Kwon
authors: Chang-Hoon
authors: CH
authors: Woo
authors: Hee-Duk
authors: HD
authors: Ahn
authors: Young-Sam
authors: YS
authors: Kwon
authors: Soo-Jin
authors: SJ
authors: Park
authors: Chang-Hyun
authors: CH
authors: Song
authors: Sae-Kwang
authors: SK
authors: Ku
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D002358:Cartilage, Articular / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D049109:Cell Proliferation / Q000187:drug effects / Q000528:radiation effects; D019902:Chondrocytes / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D004008:Diclofenac / Q000494:pharmacology; D004307:Dose-Response Relationship, Radiation; D004487:Edema / Q000473:pathology / Q000628:therapy*; D005260:Female; D007259:Infrared Rays / Q000627:therapeutic use*; D053685:Laser Therapy / Q000295:instrumentation / Q000379:methods*; D060526:Magnetic Fields; D010003:Osteoarthritis / Q000473:pathology / Q000628:therapy*; D016059:Range of Motion, Articular / Q000187:drug effects / Q000528:radiation effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013640:Tarsal Joints / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac