title: Mooren's Ulcer in a Cornea Referral Practice in Korea.
abstract: OBJECTIVE
  To investigate the clinical characteristics of patients with Mooren's ulcer in the Korean population, and to identify the risk factors that affect the therapeutic outcome.
  
  
  METHODS
  We reviewed the medical records of 33 eyes of 24 Korean patients who were referred to a cornea clinic and clinically diagnosed with Mooren's ulcer.
  
  
  RESULTS
  Despite intensive immunosuppression, corneal perforation occurred in 16 of 24 (66.7%) patients, which required tectonic graft. Age was significantly correlated with corneal perforation development: the age was 52.5 ± 21.8 years in patients with perforation and 70.2 ± 6.1 years in those without perforation (p = 0.036). Also, all 8 patients who were 55 years and younger had corneal perforation, while 8 of 16 patients older than 55 years developed perforation (p = 0.022). Other factors had no significant correlation with the occurrence of perforation.
  
  
  CONCLUSIONS
  Young patients with Mooren's ulcer should be treated and carefully followed for high possibility of corneal perforation.
authors: a Department of Ophthalmology , Seoul National University Hospital, Seoul National University Hospital , Seoul , Korea and.
authors: Dong Hyun
authors: DH
authors: Kim
authors: a Department of Ophthalmology , Seoul National University Hospital, Seoul National University Hospital , Seoul , Korea and.|b Laboratory of Ocular Regenerative Medicine and Immunology , Seoul Artificial Eye Center, Seoul National University Hospital Biomedical Research Institute , Seoul , Korea.
authors: Mee Kum
authors: MK
authors: Kim
authors: a Department of Ophthalmology , Seoul National University Hospital, Seoul National University Hospital , Seoul , Korea and.|b Laboratory of Ocular Regenerative Medicine and Immunology , Seoul Artificial Eye Center, Seoul National University Hospital Biomedical Research Institute , Seoul , Korea.
authors: Won Ryang
authors: WR
authors: Wee
authors: a Department of Ophthalmology , Seoul National University Hospital, Seoul National University Hospital , Seoul , Korea and.|b Laboratory of Ocular Regenerative Medicine and Immunology , Seoul Artificial Eye Center, Seoul National University Hospital Biomedical Research Institute , Seoul , Korea.
authors: Joo Youn
authors: JY
authors: Oh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000974:Antibodies, Antinuclear / Q000097:blood; D044466:Asian People / Q000208:ethnology; D002648:Child; D057112:Corneal Perforation / Q000209:etiology* / Q000601:surgery; D003320:Corneal Ulcer / Q000150:complications* / Q000175:diagnosis / Q000208:ethnology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012017:Referral and Consultation; D056910:Republic of Korea / Q000453:epidemiology; D012217:Rheumatoid Factor / Q000276:immunology; D012307:Risk Factors; D014792:Visual Acuity / Q000502:physiology
chemical_list: D000974:Antibodies, Antinuclear; D012217:Rheumatoid Factor
keywords: Age; Korean; Mooren’s ulcer; cornea; perforation