title: Functionalized nanofibers as drug-delivery systems for osteochondral regeneration.
abstract: A wide range of drug-delivery systems are currently attracting the attention of researchers. Nanofibers are very interesting carriers for drug delivery. This is because nanofibers are versatile, flexible, nanobiomimetic and similar to extracellular matrix components, possible to be functionalized both on their surface as well as in their core, and also because they can be produced easily and cost effectively. There have been increasing attempts to use nanofibers in the construction of a range of tissues, including cartilage and bone. Nanofibers have also been favorably engaged as a drug-delivery system in cell-free scaffolds. This short overview is devoted to current applications and to further perspectives of nanofibers as drug-delivery devices in the field of cartilage and bone regeneration, and also in osteochondral reconstruction.
authors: Department of Biophysics, 2nd Faculty of Medicine, Charles University in Prague, V Úvalu 84, 150 06 Prague, Czech Republic.
authors: Evžen
authors: E
authors: Amler
authors: Eva
authors: E
authors: Filová
authors: Matej
authors: M
authors: Buzgo
authors: Eva
authors: E
authors: Prosecká
authors: Michala
authors: M
authors: Rampichová
authors: Alois
authors: A
authors: Nečas
authors: Patcharakamon
authors: P
authors: Nooeaid
authors: Aldo R
authors: AR
authors: Boccaccini
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000502:physiology*; D002356:Cartilage / Q000166:cytology; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D057139:Nanofibers / Q000737:chemistry*
keywords: bone; cartilage; drug delivery; electrospinning; liposome; nanofiber