title: Amino alcohols from the ascidian Pseudodistoma sp.
abstract: Seven new amino alcohol compounds, pseudoaminols A-G (1-7), were isolated from the ascidian Pseudodistoma sp. collected off the coast of Chuja-do, Korea. Structures of these new compounds were determined by analysis of the spectroscopic data and from chemical conversion. The presence of an N-carboxymethyl group in two of the new compounds (6 and 7) is unprecedented among amino alcohols. Several of these compounds exhibited moderate antimicrobial activity and cytotoxicity, as well as weak inhibitory activity toward Na+/K+-ATPase.
authors: Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea. wth123@snu.ac.kr.
authors: Tae Hyung
authors: TH
authors: Won
authors: Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea. lovemin90@snu.ac.kr.
authors: Minjung
authors: M
authors: You
authors: Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Korea. awhee84@naver.com.
authors: So-Hyoung
authors: SH
authors: Lee
authors: Department of Biological Science, College of Life Science, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun, Seoul 120-750, Korea. nhm@ewha.ac.kr.
authors: Boon Jo
authors: BJ
authors: Rho
authors: Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea. dongchanoh@snu.ac.kr.
authors: Dong-Chan
authors: DC
authors: Oh
authors: Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Korea. awhee84@naver.com.
authors: Ki-Bong
authors: KB
authors: Oh
authors: Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea. shinj@snu.ac.kr.
authors: Jongheon
authors: J
authors: Shin
mesh_terms: D000605:Amino Alcohols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D056910:Republic of Korea; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors; D013057:Spectrum Analysis; D014561:Urochordata / Q000378:metabolism*
chemical_list: D000605:Amino Alcohols; D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D000254:Sodium-Potassium-Exchanging ATPase