title: The King-Devick (K-D) test of rapid eye movements: a bedside correlate of disability and quality of life in MS.
abstract: OBJECTIVE
  We investigated the King-Devick (K-D) test of rapid number naming as a visual performance measure in a cohort of patients with multiple sclerosis (MS).
  
  
  METHODS
  In this cross-sectional study, 81 patients with MS and 20 disease-free controls from an ongoing study of visual outcomes underwent K-D testing. A test of rapid number naming, K-D requires saccadic eye movements as well as intact vision, attention and concentration. To perform the K-D test, participants are asked to read numbers aloud as quickly as possible from three test cards; the sum of the three test card times in seconds constitutes the summary score. High-contrast visual acuity (VA), low-contrast letter acuity (1.25% and 2.5% levels), retinal nerve fiber layer (RNFL) thickness by optical coherence tomography (OCT), MS Functional Composite (MSFC) and vision-specific quality of life (QOL) measures (25-Item NEI Visual Functioning Questionnaire [NEI-VFQ-25] and 10-Item Neuro-Ophthalmic Supplement) were also assessed.
  
  
  RESULTS
  K-D time scores in the MS cohort (total time to read the three test cards) were significantly higher (worse) compared to those for disease-free controls (P=0.003, linear regression, accounting for age). Within the MS cohort, higher K-D scores were associated with worse scores for the NEI-VFQ-25 composite (P<0.001), 10-Item Neuro-Ophthalmic Supplement (P<0.001), binocular low-contrast acuity (2.5%, 1.25%, P<0.001, and high-contrast VA (P=0.003). Monocular low-contrast vision scores (P=0.001-0.009) and RNFL thickness (P=0.001) were also reduced in eyes of patients with worse K-D scores (GEE models accounting for age and within-patient, inter-eye correlations). Patients with a history of optic neuritis (ON) had increased (worse) K-D scores. Patients who classified their work disability status as disabled (receiving disability pension) did worse on K-D testing compared to those working full-time (P=0.001, accounting for age).
  
  
  CONCLUSIONS
  The K-D test, a <2 minute bedside test of rapid number naming, is associated with visual dysfunction, neurologic impairment, and reduced vision-specific QOL in patients with MS. Scores reflect work disability as well as structural changes as measured by OCT imaging. History of ON and abnormal binocular acuities were associated with worse K-D scores, suggesting that abnormalities detected by K-D may go along with afferent dysfunction in MS patients. A brief test that requires saccadic eye movements, K-D should be considered for future MS trials as a rapid visual performance measure.
authors: Department of Neurology, New York University School of Medicine, New York, NY, United States.
authors: Stephen
authors: S
authors: Moster
authors: Department of Neurology, New York University School of Medicine, New York, NY, United States.
authors: James A
authors: JA
authors: Wilson
authors: Department of Neurology, New York University School of Medicine, New York, NY, United States.
authors: Steven L
authors: SL
authors: Galetta
authors: Department of Neurology, New York University School of Medicine, New York, NY, United States; Department of Population Health, New York University School of Medicine, New York, NY, United States. Electronic address: laura.balcer@nyumc.org.
authors: Laura J
authors: LJ
authors: Balcer
mesh_terms: D000328:Adult; D004185:Disability Evaluation; D006233:Persons with Disabilities; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D009460:Neurologic Examination; D011788:Quality of Life; D012160:Retina / Q000473:pathology; D012895:Sleep, REM / Q000502:physiology*; D013223:Statistics as Topic; D013997:Time Factors; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology
keywords: King–Devick; Low-contrast letter acuity; Optical coherence tomography; Quality of life; Retinal nerve fiber layer; Visual acuity