title: Hereditary colorectal cancer syndromes and genetic testing.
abstract: Colorectal cancer (CRC) is a leading cause of cancer and cancer deaths in the Western world. Approximately 5-10% of CRC are hereditary, due to a defined genetic cause. Individuals and families affected with a hereditary CRC syndrome exhibit benign and malignant extra-intestinal tumors, require aggressive cancer screening and benefit from management by a multi-disciplinary team of professionals. The clinical manifestations, genetic causes and current management of patients with hereditary colon cancer syndrome is provided.
authors: Department of Gastroenterology and Hepatology, The Cleveland Clinic, Cleveland, Ohio.
authors: Carole
authors: C
authors: Macaron
authors: Brandie H
authors: BH
authors: Leach
authors: Carol A
authors: CA
authors: Burke
mesh_terms: D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D005820:Genetic Testing; D006801:Humans; D009386:Neoplastic Syndromes, Hereditary / Q000175:diagnosis* / Q000235:genetics*
keywords: colon cancer; genetic testing; hereditary syndromes