title: Delayed tumor resection in a 5-year-old child with bilateral Wilms tumor.
abstract: We describe the case of a 5-year-old girl whose abdominal pain and distension were caused by Wilms tumor of the kidney. Because of the bilateral nature of her disease, she was spared biopsy or initial nephrectomy as part of her treatment course. Rather, she was treated presumptively for Wilms tumor based primarily on radiologic findings. Neoadjuvant chemotherapy consisting of vincristine, dactinomycin and doxorubicin was given to facilitate nephron-sparing surgery for tumor resection. Her initial chemotherapeutic course was complicated by tumor lysis syndrome manifested by elevated serum uric acid and was treated effectively with hyperhydration and alkalization of intravenous fluids. The patient's disease responded well to chemotherapy, and she underwent successful tumor excision after 12 weeks of chemotherapy. The resected tumor was identified as anaplastic Wilms tumor, illustrating that pathologic identification of Wilms tumor is possible even after multiple cycles of neoadjuvant chemotherapy and marked tumor shrinkage.
authors: University of Kentucky College of Medicine, Lexington, KY, USA.
authors: Samuel P
authors: SP
authors: Carmichael
authors: Department of Pathology, University of Kentucky College of Medicine, Lexington, KY, USA.
authors: Joseph F
authors: JF
authors: Pulliam
authors: Department of Pediatrics (Hematology-Oncology) and the Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY, USA jdorazio@uky.edu.
authors: John A
authors: JA
authors: D'Orazio