title: Association of platelet glycoprotein receptor alpha2beta1 integrin and glycoprotein IIIa gene polymorphisms with diabetic retinopathy: evidence from 3007 subjects.
abstract: OBJECTIVE
  Many epidemiological studies have evaluated associations of platelet glycoprotein receptor alpha2beta1 integrin (ITGA2) and glycoprotein IIIa (ITGB3) gene polymorphisms with diabetic retinopathy (DR), but the published data are inconclusive. The aim of the present study was to assess the associations by using meta-analysis.
  
  
  METHODS
  A comprehensive electronic search (PubMed, EMBASE, Elsevier Science Direct, CNKI and Wanfang) was carried out until 31 August 2013. Odds ratios (ORs) and its 95% confidence intervals (CIs) were used to assess the strength of the associations.
  
  
  RESULTS
  Nine studies including 1678 cases and 1329 controls were included in the meta-analysis. Meta-analysis was performed for ITGA2 gene BgI II polymorphism (7 studies including 758 cases and 570 controls) and ITGB3 gene PlA1/A2 polymorphism (4 studies including 1047 cases and 861 controls). Significant associations were found for BgI II (+ versus -: OR = 1.42, 95% CI = 1.06-1.90, p = 0.02; +/- + +/+ versus -/-: OR = 1.46, 95% CI = 0.99-2.15, p = 0.06; +/+ versus -/- + +/-: OR = 1.90, 95% CI = 1.35-2.67, p = 0.0003) and PlA1/A2 (A2 versus A1: OR = 0.74, 95% CI = 0.52-1.07, p = 0.11; A1A2 + A2A2 versus A1A1: OR = 0.80, 95% CI = 0.64-0.99, p = 0.04; A2A2 versus A1A1 + A1A2: OR = 0.45, 95% CI = 0.27-0.75, p = 0.002) polymorphisms.
  
  
  CONCLUSIONS
  This meta-analysis demonstrates that DR is associated with ITGA2 BgI II and ITGB3 PlA1/A2 polymorphisms.
authors: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University , Hefei, Anhui , China .
authors: Jian-Yang
authors: JY
authors: Gong
authors: Da-Tong
authors: DT
authors: Deng
authors: Ye-Huan
authors: YH
authors: Sun
mesh_terms: D003930:Diabetic Retinopathy / Q000235:genetics* / Q000378:metabolism; D005838:Genotype; D006801:Humans; D038982:Integrin alpha2beta1 / Q000235:genetics* / Q000378:metabolism; D039661:Integrin beta3 / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: C061248:ITGB3 protein, human; D038982:Integrin alpha2beta1; D039661:Integrin beta3
keywords: Diabetic retinopathy; glycoprotein IIIa; glycoprotein receptor alpha2beta1 integrin; meta-analysis; polymorphism