title: Allelic imbalance in the miR-31 host gene locus in lung cancer--its potential role in carcinogenesis.
abstract: Small non-protein coding RNA, microRNA (miR), which regulate messenger RNA levels, have recently been identified, and may play important roles in the pathogenesis of various diseases. The present study focused on miR-31 and investigated its potential involvement in lung carcinogenesis. The expression of miR-31 was altered in lung cancer cells through either the amplification or loss of the host gene locus. The strong expression of miR-31 in large cell carcinomas was attributed to the gene amplification. Meanwhile, the loss of miR-31 expression was more frequently observed in aggressive adenocarcinomas. Thus, miR-31 may play a pleiotropic role in the development of lung cancers among different histological types. To the best of our knowledge, this is the first study to show the potential causative mechanism of the altered expression of miR-31 and suggest its potentially diverse significance in the different histological types of lung cancers.
authors: Department of Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors: Koji
authors: K
authors: Okudela
authors: Department of Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors: Yoko
authors: Y
authors: Tateishi
authors: Department of Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors: Shigeaki
authors: S
authors: Umeda
authors: Department of Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors: Hideaki
authors: H
authors: Mitsui
authors: Department of Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors: Takeshisa
authors: T
authors: Suzuki
authors: Department of Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors: Yuichi
authors: Y
authors: Saito
authors: Department of Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors: Tetsukan
authors: T
authors: Woo
authors: Division of General Thoracic Surgery, Kanagawa Cardiovascular and Respiratory Disease Center Hospital, Yokohama, Japan.
authors: Michihiko
authors: M
authors: Tajiri
authors: Department of Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors: Munetaka
authors: M
authors: Masuda
authors: Clinical Research Institute, Kanagawa Prefectural Cancer Center Hospital, Yokohama, Japan.
authors: Yohei
authors: Y
authors: Miyagi
authors: Department of Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors: Kenichi
authors: K
authors: Ohashi
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D022981:Allelic Imbalance; D063646:Carcinogenesis / Q000235:genetics / Q000473:pathology; D018287:Carcinoma, Large Cell / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D018288:Carcinoma, Small Cell / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D045744:Cell Line, Tumor; D018628:Gene Dosage; D015972:Gene Expression Regulation, Neoplastic; D056426:Genetic Loci; D058685:Genetic Pleiotropy; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D035683:MicroRNAs / Q000235:genetics*
chemical_list: C534612:MIRN31 microRNA, human; D035683:MicroRNAs