title: Metalloproteinases in hypertension and cardiac disease: differential expression and mutual regulation.
abstract: Arterial hypertension, a condition characterized by sustained elevated blood pressure, is associated with pathological cardiac remodeling (i.e. cardiac hypertrophy and fibrosis) and is a major risk factor for cardiac failure. These processes can be triggered by excess vasoconstrictive agonists, which induce metalloproteinase-dependent shedding of growth factors to transactivate growth factor receptors and initiate disease signaling. Here, we review emerging evidence that agonist-activated metalloproteinases exhibit different expression patterns and mutual transcriptional regulation during the development of hypertension and cardiac remodeling.
authors: Department of Biochemistry, School of Molecular and Systems Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada ; The Cardiovascular Research Group, University of Alberta, Edmonton, AB, Canada.
authors: Ana-Maria
authors: AM
authors: Bosonea
authors: Department of Biochemistry, School of Molecular and Systems Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada ; The Cardiovascular Research Group, University of Alberta, Edmonton, AB, Canada.
authors: Xiang
authors: X
authors: Wang
authors: Department of Biochemistry, School of Molecular and Systems Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada ; The Cardiovascular Research Group, University of Alberta, Edmonton, AB, Canada.
authors: Jeffrey
authors: J
authors: Odenbach
authors: Department of Biochemistry, School of Molecular and Systems Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada ; The Cardiovascular Research Group, University of Alberta, Edmonton, AB, Canada ; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada.
authors: Carlos
authors: C
authors: Fernandez-Patron