title: Neuromodulation in developing motor microcircuits.
abstract: Neuromodulation confers operational flexibility on motor network output and resulting behaviour. Furthermore, neuromodulators play crucial long-term roles in the assembly and maturational shaping of the same networks as they develop. Although previous studies have identified such modulator-dependent contributions to microcircuit ontogeny, some of the underlying mechanisms are only now being elucidated. Deciphering the role of neuromodulatory systems in motor network development has potentially important implications for post-lesional regenerative strategies in adults.
authors: School of Psychology and Neuroscience, University of St Andrews, Westburn Lane, St Andrews, Fife KY16 9JP, Scotland, UK. Electronic address: kts1@st-andrews.ac.uk.
authors: Keith T
authors: KT
authors: Sillar
authors: Université de Bordeaux, Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, CNRS Unité Mixte de Recherche 5287, 146 rue Léo Saignat, 33076 Bordeaux, France.
authors: Denis
authors: D
authors: Combes
authors: Université de Bordeaux, Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, CNRS Unité Mixte de Recherche 5287, 146 rue Léo Saignat, 33076 Bordeaux, France.
authors: John
authors: J
authors: Simmers
mesh_terms: D000818:Animals; D005075:Biological Evolution; D004525:Efferent Pathways / Q000502:physiology*; D006801:Humans; D009046:Motor Neurons / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000502:physiology*
chemical_list: D018377:Neurotransmitter Agents