title: [Cu(OH)(TMEDA)]₂Cl₂-catalyzed regioselective 2-arylation of 5-substituted tetrazoles with boronic acids under mild conditions.
abstract: A mild and regioselective 2-arylation of 5-substituted tetrazoles is described. The reaction proceeds regioselectively with a variety of arylboronic acids in the presence of [Cu(OH)(TMEDA)]2Cl2 to afford 2,5-disubstituted tetrazoles. This is the first report of highly regioselective arylation of 5-alkyltetrazoles.
authors: Fujimoto Chemicals Co., Ltd. , 1-2-38, Kinrakuji-cho, Amagasaki, Hyogo 660-0806, Japan.
authors: Takuya
authors: T
authors: Onaka
authors: Hideaki
authors: H
authors: Umemoto
authors: Yasuyoshi
authors: Y
authors: Miki
authors: Akira
authors: A
authors: Nakamura
authors: Tomohiro
authors: T
authors: Maegawa
mesh_terms: D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D013777:Tetrazoles / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D001897:Boronic Acids; D056831:Coordination Complexes; D013777:Tetrazoles; D003300:Copper