title: Design, synthesis and biological evaluation of mitochondria targeting theranostic agents.
abstract: Dual mitochondria targeting fluorescent F16-TPP analogues were designed and synthesized. Uptake and cytotoxicity studies indicate that FF16 and FF16-TPP, two compounds discovered in this study, are promising mitochondria targeting theranostic agents.
authors: Molecular Imaging Program at Stanford (MIPS), Bio-X Program, Department of Radiology, Stanford University, California, 94305-5344, USA. zcheng@stanford.edu.
authors: Song
authors: S
authors: Wu
authors: Qizhen
authors: Q
authors: Cao
authors: Xiaolin
authors: X
authors: Wang
authors: Kai
authors: K
authors: Cheng
authors: Zhen
authors: Z
authors: Cheng
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D015195:Drug Design; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D008928:Mitochondria / Q000378:metabolism*; D009861:Onium Compounds / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D061848:Optical Imaging; D009943:Organophosphorus Compounds / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D011726:Pyridinium Compounds / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D009861:Onium Compounds; D009943:Organophosphorus Compounds; D011726:Pyridinium Compounds; C471842:4-(2-(indol-3-yl)vinyl)-1-methylpyridinium; C013289:tetraphenylphosphonium