title: Effect of oral administration of unfractionated heparin (UFH) on coagulation parameters in plasma and levels of urine and fecal heparin in dogs.
abstract: The effects of heparin administration, by the oral route, were evaluated in dogs. In single and multiple dose studies (single 7.5 mg/kg, multiple 3 × 7.5 mg/kg per 48 h), plasma, urine, and fecal samples were collected at various times up to 120 h after oral administration of unfractionated heparin. Changes in plasma and urine anti-Xa activity, plasma and urine anti-IIa activity, plasma activated partial thromboplastin time (APTT) and antithrombin (ATIII), and chemical heparin in urine and feces were examined with time. There was support for heparin absorption, with significant differences in APTT, heparin in plasma as determined by anti-Xa activity (Heptest) in the single dose study and plasma anti-Xa activity, anti-IIa activity and ATIII; and chemical heparin in urine in the multiple dose study. No clinical evidence of bleeding was detected in any dog during the studies. Oral heparin therapy may be applicable for thromboembolic disease in animals. Further studies are warranted to determine the effects of oral heparin at the endothelial level in the dog.
authors: Department of Small Animal Clinical Sciences (Erickson, Carr, Stickney) and Department of Veterinary Biomedical Sciences (Hiebert), Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4.
authors: Malathi
authors: M
authors: Erickson
authors: Department of Small Animal Clinical Sciences (Erickson, Carr, Stickney) and Department of Veterinary Biomedical Sciences (Hiebert), Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4.
authors: Linda M
authors: LM
authors: Hiebert
authors: Department of Small Animal Clinical Sciences (Erickson, Carr, Stickney) and Department of Veterinary Biomedical Sciences (Hiebert), Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4.
authors: Anthony P
authors: AP
authors: Carr
authors: Department of Small Animal Clinical Sciences (Erickson, Carr, Stickney) and Department of Veterinary Biomedical Sciences (Hiebert), Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4.
authors: Jocelyn D
authors: JD
authors: Stickney
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology / Q000652:urine; D000991:Antithrombins / Q000378:metabolism; D004285:Dogs / Q000097:blood* / Q000378:metabolism* / Q000652:urine; D015949:Factor IXa / Q000378:metabolism; D015951:Factor Xa / Q000378:metabolism; D005243:Feces / Q000737:chemistry*; D005260:Female; D006493:Heparin / Q000097:blood* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000652:urine; D008297:Male; D011516:Prothrombin / Q000378:metabolism
chemical_list: D000925:Anticoagulants; D000991:Antithrombins; D011516:Prothrombin; C025337:Factor IIa; D006493:Heparin; D015949:Factor IXa; D015951:Factor Xa