title: Coronary artery indexed diameter and z score regression equations in healthy Chinese Han children.
abstract: OBJECTIVE
  In children with coronary disease, clinical decision should be based on detailed measurements of the coronary arteries by two-dimensional echocardiography. We aimed to establish coronary artery reference indexed diameter and z scores regression equations in a large cohort of Chinese Han children.
  
  
  METHODS
  We measured the diameter of the proximal right (RCA), left main (LMCA), left anterior descending, and left circumflex coronary artery, and of the aortic annulus, and calculated the coronary-aorta index (coronary artery-to-aortic annulus ratio) in 506 Chinese Han children with normal hearts whose ages ranged from 1 day to 18 years. Regression analyses were performed, relating the coronary artery dimensions to body surface area (BSA). Several models were used, and the best model (yielding the maximum adjusted R(2) ) was chosen to establish a z score calculator.
  
  
  RESULTS
  Based on cubic regression, (M) = β0 + β1 × BSA + β2 × BSA(2)  + β3 × BSA(3) , the adjusted R(2) values were 0.515, 0.553, 0.505, and 0.518 for the RCA, LMCA, left anterior descending, and left circumflex coronary artery models, respectively. RCA/aortic annulus was 0.14 ± 0.02 (range, 0.07-0.24) and LMCA/AOA was 0.15 ± 0.03 (range, 0.10-0.28).
  
  
  CONCLUSIONS
  Our results provide reference values of coronary artery z scores, regression equation, and coronary-aorta index as a quick guide to determine coronary dilation in Chinese Han children.
authors: Department of Pediatric Cardiology, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, 200127, China.
authors: Yu-qi
authors: YQ
authors: Zhang
authors: Shu-bao
authors: SB
authors: Chen
authors: Guo-ying
authors: GY
authors: Huang
authors: Hong-yan
authors: HY
authors: Zhang
authors: Mei-rong
authors: MR
authors: Huang
authors: Shan-shan
authors: SS
authors: Wang
authors: Lan-ping
authors: LP
authors: Wu
authors: Wen-jing
authors: WJ
authors: Hong
authors: Rong
authors: R
authors: Shen
authors: Yi-qing
authors: YQ
authors: Liu
authors: Jun-xue
authors: JX
authors: Zhu
authors: Zhao-hui
authors: ZH
authors: Lu
mesh_terms: D000293:Adolescent; D001011:Aorta / Q000033:anatomy & histology / Q000000981:diagnostic imaging; D001837:Body Weights and Measures; D002648:Child; D002675:Child, Preschool; D002681:China; D015331:Cohort Studies; D003331:Coronary Vessels / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012016:Reference Values; D014463:Ultrasonography
keywords: Kawasaki disease; coronary artery; echocardiography; z scores