title: Ovulation induction with clomiphene citrate for infertile couple.
abstract: OBJECTIVE
  Among couples unable to conceive without any identifiable cause, 30% are defined as having unexplained infertility. Management depends on duration of infertility and age of female partner. In order to increase pregnancy rate, couples with infertility of unknown origin can undergo ovulation induction and intrauterine insemination. These techniques are able to increase pregnancy rate in case of unexplained infertility. Clomiphene citrate and menopausal or recombinant gonodotropins are the most used drugs to induce ovulation. Aim of the present study was to evaluate the success rate after homologous intrauterine insemination (IUI) combined with clomiphene citrate (CC) stimulation.
  
  
  METHODS
  A total of 77 couples were evaluated. Nine couples (11.6%) were excluded from the treatment (vaginal infections 4, tubal occlusions 3 and male sterility 2). Informed consent was applied for every couple. The remaining 68 couples were divided in two groups: group A (34 couples) were inducted with CC, while group B (34 couples) underwent placebo (multivitamin).
  
  
  RESULTS
  In group A (CC) 15 (44.1%) pregnancies and 3 (8.8%) abortion were registered, while in group B (placebo) there were 4 (11.7%) pregnancies and 1 (2.9%) abortion.
  
  
  CONCLUSIONS
  Ovulation inductions with CC, together with intrauterine insemination, improves fecundity in patients with infertility of unknown origin with no need to recur to more invasive techniques.
authors: Department of Surgery Obstetrics and Gynecology, University of Catania, Catania, Italy - federicagrasso88@gmail.com.
authors: V
authors: V
authors: Leanza
authors: L
authors: L
authors: Coco
authors: F
authors: F
authors: Grasso
authors: G
authors: G
authors: Leanza
authors: G
authors: G
authors: Zarbo
authors: M
authors: M
authors: Palumbo
mesh_terms: D000328:Adult; D002996:Clomiphene / Q000627:therapeutic use*; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use*; D006801:Humans; D007246:Infertility / Q000209:etiology / Q000628:therapy; D007315:Insemination, Artificial / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D016896:Treatment Outcome
chemical_list: D005300:Fertility Agents, Female; D002996:Clomiphene