title: Multifocal interferometric synthetic aperture microscopy.
abstract: There is an inherent trade-off between transverse resolution and depth of field (DOF) in optical coherence tomography (OCT) which becomes a limiting factor for certain applications. Multifocal OCT and interferometric synthetic aperture microscopy (ISAM) each provide a distinct solution to the trade-off through modification to the experiment or via post-processing, respectively. In this paper, we have solved the inverse problem of multifocal OCT and present a general algorithm for combining multiple ISAM datasets. Multifocal ISAM (MISAM) uses a regularized combination of the resampled datasets to bring advantages of both multifocal OCT and ISAM to achieve optimal transverse resolution, extended effective DOF and improved signal-to-noise ratio. We present theory, simulation and experimental results.
authors: Yang
authors: Y
authors: Xu
authors: Xiong Kai Benjamin
authors: XK
authors: Chng
authors: Steven G
authors: SG
authors: Adie
authors: Stephen A
authors: SA
authors: Boppart
authors: P Scott
authors: PS
authors: Carney
mesh_terms: D000465:Algorithms; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007368:Interferometry / Q000295:instrumentation*; D008857:Microscopy, Interference / Q000295:instrumentation*; D041623:Tomography, Optical Coherence / Q000295:instrumentation*