title: Nickel-catalyzed site-selective amidation of unactivated C(sp(3))-H bonds.
abstract: Intramolecular dehydrogenative cyclization of aliphatic amides was achieved on unactivated sp(3) carbon atoms by a nickel-catalyzed CH bond functionalization process with the assistance of a bidentate directing group. The reaction favors the CH bonds of β-methyl groups over the γ-methyl or β-methylene groups. Additionally, a predominant preference for the β-methyl CH bonds over the aromatic sp(2) CH bonds was observed. Moreover, this process also allows for the effective functionalization of benzylic secondary sp(3) CH bonds.
authors: Department of Chemistry and Chemical Biology, Indiana University Purdue University Indianapolis, Indianapolis, Indiana 46202 (USA), Fax: (+1) 317-2744701.
authors: Xuesong
authors: X
authors: Wu
authors: Yan
authors: Y
authors: Zhao
authors: Haibo
authors: H
authors: Ge
keywords: CH bond functionalization; amidation; nickel; site selectivity; β-lactams