title: Study of subretinal exudation and consequent changes in acute central serous chorioretinopathy by optical coherence tomography.
abstract: OBJECTIVE
  To investigate the characteristics of subretinal exudation and consequent morphologic changes in acute central serous chorioretinopathy (CSC) using spectral-domain optical coherence tomography (OCT).
  
  
  METHODS
  Prospective, observational, cross-sectional case series.
  
  
  METHODS
  Patients with CSC with symptom duration of fewer than 3 months underwent visual acuity measurement, fundus observation and spectral-domain OCT examinations and then were evaluated for subretinal exudation and other changes.
  
  
  RESULTS
  A total of 123 patients (123 eyes) were included, all showing various retinal pigment epithelium (RPE) abnormalities on OCT. OCT also showed subretinal exudation (65 eyes, 52.8%); retinal dipping (14 eyes, 11.4%); and photoreceptor layer defects (88 eyes, 71.5%). Without exception, the locations of these pathologic changes were closely related to the abnormal sites in the RPE. Those with subretinal exudation showed shorter durations of symptoms, whereas those with photoreceptor layer defects showed longer durations. In most eyes with retinal dipping, exudation connected it to RPE abnormalities. The defects of the photoreceptor layer, which involved the photoreceptor outer segment in 68 eyes, the photoreceptor inner segment in 20 eyes, and the outer nuclear layer as well, were likely to be the consequence of retinal dipping.
  
  
  CONCLUSIONS
  OCT findings suggested that in eyes with acute CSC subretinal exudation, which indicated fibrin leakage through the RPE defects, might cause retinal dipping, thus leading to photoreceptor layer defects, and that spectral-domain OCT could provide a better understanding of the pathologic changes in acute CSC.
authors: Department of Ophthalmology, Eye and Ear Nose Throat Hospital of Fudan University, Shanghai, China.
authors: Jia
authors: J
authors: Yu
authors: Department of Ophthalmology, Eye and Ear Nose Throat Hospital of Fudan University, Shanghai, China. Electronic address: chhjiang70@163.com.
authors: Chunhui
authors: C
authors: Jiang
authors: Department of Ophthalmology, Eye and Ear Nose Throat Hospital of Fudan University, Shanghai, China; Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, China.
authors: Gezhi
authors: G
authors: Xu
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D056833:Central Serous Chorioretinopathy / Q000175:diagnosis* / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D055213:Retinal Pigment Epithelium / Q000473:pathology*; D058471:Subretinal Fluid / Q000378:metabolism*; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult