title: Antithrombotic and antidiabetic flavonoid glycosides from the grains of Sorghum bicolor (L.) Moench var. hwanggeumchal.
abstract: A phytochemical study of the grains of S. bicolor, resulting in the isolation of twelve flavonoid glycosides 1-12. Their chemical structures were elucidated on the basis of spectroscopic (1D and 2D NMR) and MS data analyses. All compounds were tested on thrombin time (TT) assay and α-glucosidase assay in order to assess their inhibitory effects on blood coagulation and α-glucosidase enzyme. At the concentration of 500 μg/mL, compounds 3, 4, 7 and 10 possessed the potential effects on blood coagulation with inhibitory percentage of 197, 152, 120 and 158 %, respectively, whereas aspirin, which used as a positive control, indicated 181 and 138 % inhibition at 500 and 375 μg/mL, respectively. Furthermore, compounds 3, 4, 7, 9 and 10 also displayed strong inhibitory effects on α-glucosidase enzyme, with 85.2, 55.7, 43.9, 52.7 and 65.2 % inhibition at 100 μg/mL, respectively, whereas acarbose, as a positive control, possessed only 38.7 % at the same concentration. Taken together, our data suggest that S. bicolor and its flavonoid-enrich extracts could be considered as supplemental and or functional foods having beneficial effects against blood coagulation-induced ischemia, possibly thromboembolism disease, as well as diabetes.
authors: College of Pharmacy, Catholic University of Daegu, Hayang, 712-702, Gyeongbuk, Korea.
authors: Phi-Hung
authors: PH
authors: Nguyen
authors: Vu Viet
authors: VV
authors: Dung
authors: Bing Tian
authors: BT
authors: Zhao
authors: Young Ho
authors: YH
authors: Kim
authors: Byung Sun
authors: BS
authors: Min
authors: Mi Hee
authors: MH
authors: Woo
mesh_terms: D001777:Blood Coagulation / Q000187:drug effects; D005343:Fibrinolytic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology; D065089:Glycoside Hydrolase Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007004:Hypoglycemic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D066298:In Vitro Techniques; D012639:Seeds / Q000737:chemistry; D045868:Sorghum / Q000737:chemistry*; D013918:Thrombin Time; D000520:alpha-Glucosidases / Q000737:chemistry
chemical_list: D005343:Fibrinolytic Agents; D005419:Flavonoids; D065089:Glycoside Hydrolase Inhibitors; D006027:Glycosides; D007004:Hypoglycemic Agents; D000520:alpha-Glucosidases