title: Prognostic value of matrix metalloproteinase 9 expression in patients with juvenile nasopharyngeal angiofibroma: tissue microarray analysis.
abstract: OBJECTIVE
  Although JNA is a benign neoplasm histopathologically, it has a propensity for locally destructive growth and remains a higher postoperative recurrence rate. The aim of this study was to analyze the expression and localization of MMP-9 in JNA using tissue microarray to elucidate its correlation with clinicopathological features and recurrence.
  
  
  METHODS
  The expression of MMP-9 was assessed by immunohistochemistry in a tissue microarray from 70 patients with JNA and 10 control subjects. Correlation between the levels of MMP-9 expression and clinicopathologic variables, as well as tumor recurrence, were analyzed.
  
  
  RESULTS
  MMP-9 was detected in perivascular and extravascular less differentiated cells and stromal cells of patients with JNA but not in the matured vascular endothelial cells of these patients. The presence of MMP-9 expression in JNA was correlated with patient's age (p=0.001). Spearman correlation analysis suggested that high expression of MMP-9 in JNA had negative correlation with patient's age (r=-0.412, p<0.001). The recurrence rate in JNA patients with high MMP-9 expression was significantly higher than those with low MMP-9 expression (p=0.002). In multivariate and ROC curve analysis, MMP-9 was a good prognostic factor for tumor recurrence of JNA.
  
  
  CONCLUSIONS
  Higher MMP-9 expression is a poor prognostic factor for patients with JNA who have been surgically treated.
authors: Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
authors: Xicai
authors: X
authors: Sun
authors: Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
authors: Limin
authors: L
authors: Guo
authors: Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
authors: Jingjing
authors: J
authors: Wang
authors: Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
authors: Huan
authors: H
authors: Wang
authors: Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
authors: Zhuofu
authors: Z
authors: Liu
authors: Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
authors: Juan
authors: J
authors: Liu
authors: Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
authors: Huapeng
authors: H
authors: Yu
authors: Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
authors: Li
authors: L
authors: Hu
authors: Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
authors: Han
authors: H
authors: Li
authors: Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address: wangdehuient@sina.com.
authors: Dehui
authors: D
authors: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D018322:Angiofibroma / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D015999:Multivariate Analysis; D009303:Nasopharyngeal Neoplasms / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000201:enzymology*; D011379:Prognosis; D017154:Stromal Cells / Q000201:enzymology; D046888:Tissue Array Analysis; D055815:Young Adult
chemical_list: D020780:Matrix Metalloproteinase 9
keywords: Juvenile nasopharyngeal angiofibroma (JNA); Matrix metalloproteinase 9(MMP-9); Prognosis; Tissue microarray (TMA)