title: Mukaiyama Aldol Reactions in Aqueous Media.
abstract: Mukaiyama aldol reactions in aqueous media have been surveyed. While the original Mukaiyama aldol reactions entailed stoichiometric use of Lewis acids in organic solvents under strictly anhydrous conditions, Mukaiyama aldol reactions in aqueous media are not only suitable for green sustainable chemistry but are found to produce singular phenomena. These findings led to the discovery of a series of water-compatible Lewis acids such as lanthanide triflates in 1991. Our understanding on these beneficial effects in the presence of water will be deepened through the brilliant examples collected in this review. 1 Introduction 2 Rate Enhancement by Water in the Mukaiyama Aldol Reaction 3 Lewis Acid Catalysis in Aqueous or Organic Solvents 3.1 Water-Compatible Lewis Acids 4 Lewis-Base Catalysis in Aqueous or Organic Solvents 5 The Mukaiyama Aldol Reactions in 100% Water 6 Asymmetric Catalysts in Aqueous Media and Water 7 Conclusions and Perspective.
authors: Department of Chemistry, School of Science, The University of Tokyo Hongo, Bunkyo-ku, Tokyo, Japan, ; phone: (+81)-(0)3-5841-4790 e-mail: shu_kobayashi@chem.s.u-tokyo.ac.jp.
authors: Taku
authors: T
authors: Kitanosono
authors: Department of Chemistry, School of Science, The University of Tokyo Hongo, Bunkyo-ku, Tokyo, Japan, ; phone: (+81)-(0)3-5841-4790 e-mail: shu_kobayashi@chem.s.u-tokyo.ac.jp.
authors: Shū
authors: S
authors: Kobayashi
keywords: Lewis acids; aldol reaction; asymmetric catalysis; green chemistry; water