title: Low-molecular -weight heparin in pregnancies after ART -a retrospective study-.
abstract: BACKGROUND
  The utility of an antithrombotic prophylaxis in Assisted Reproductive Technologies (ART) is highly debated. It has been hypothesised that specific effects of heparin on the coagulation system during implantation can improve the number of clinical pregnancies and live births.
  
  
  METHODS
  We studied a cohort of 327 women undergone at least 1 ART cycle before thrombophilia testing. Overall, a number of 751cycles was analysed. Low-Molecular-Weight Heparin (LMWH) and/or low-dose aspirin (ASA) were prescribed in 132 (17.6%) cycles. Furthermore, all the women underwent thrombophilia screening.
  
  
  RESULTS
  The univariate analysis showed that LMWH with/without ASA was significantly associated with both the outcomes clinical pregnancy and live birth, while the use of ASA was not associated with live birth. The logistic regression showed that the use of LMWH was significantly associated with both the outcomes, clinical pregnancy (OR: 6.0, 95%CI: 2.8-15.6) and live birth (OR: 10.7, 95%CI: 3.2-36.1). The type of ART procedure significantly influenced the likelihood of achieving clinical pregnancy.
  
  
  CONCLUSIONS
  Present findings suggest that LMWH alone or combined with ASA could have a role in fostering the implantation of embryos and improving the number of live births after ART.
authors: Atherosclerosis and Thrombosis Unit, I.R.C.C.S. "Casa Sollievo della Sofferenza", S. Giovanni Rotondo, Foggia, Italy. Electronic address: e.grandone@operapadrepio.it.
authors: E
authors: E
authors: Grandone
authors: Atherosclerosis and Thrombosis Unit, I.R.C.C.S. "Casa Sollievo della Sofferenza", S. Giovanni Rotondo, Foggia, Italy.
authors: M
authors: M
authors: Villani
authors: Department of Clinical Medicine, Insubria University, Varese, Italy.
authors: F
authors: F
authors: Dentali
authors: Atherosclerosis and Thrombosis Unit, I.R.C.C.S. "Casa Sollievo della Sofferenza", S. Giovanni Rotondo, Foggia, Italy.
authors: G L
authors: GL
authors: Tiscia
authors: Atherosclerosis and Thrombosis Unit, I.R.C.C.S. "Casa Sollievo della Sofferenza", S. Giovanni Rotondo, Foggia, Italy.
authors: D
authors: D
authors: Colaizzo
authors: Atherosclerosis and Thrombosis Unit, I.R.C.C.S. "Casa Sollievo della Sofferenza", S. Giovanni Rotondo, Foggia, Italy.
authors: F
authors: F
authors: Cappucci
authors: Atherosclerosis and Thrombosis Unit, I.R.C.C.S. "Casa Sollievo della Sofferenza", S. Giovanni Rotondo, Foggia, Italy.
authors: L
authors: L
authors: Fischetti
authors: Department of Clinical Medicine, Insubria University, Varese, Italy.
authors: W
authors: W
authors: Ageno
authors: Medical Genetics, University of Foggia, Foggia, Italy.
authors: M
authors: M
authors: Margaglione
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use*; D001241:Aspirin / Q000627:therapeutic use*; D010064:Embryo Implantation; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D006801:Humans; D050498:Live Birth; D008875:Middle Aged; D011247:Pregnancy; D011256:Pregnancy Outcome; D027724:Reproductive Techniques, Assisted; D012189:Retrospective Studies; D019851:Thrombophilia / Q000175:diagnosis; D055815:Young Adult
chemical_list: D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight; D001241:Aspirin
keywords: Aspirin; Assisted Reproductive Technologies; Low-molecular- weight heparins