title: Red ginseng delays age-related hearing and vestibular dysfunction in C57BL/6 mice.
abstract: Since Korean red ginseng (KRG) has been proven to protect against gentamicin-induced vestibular and hearing dysfunction, the effects of KRG on age-related inner ear disorder in C57BL/6 mice were investigated. While age-related hearing loss was detected at the age of 6months (32kHz) and 9months (16kHz) in the control group, it was significantly delayed (p<0.05) in the 150mg/kg KRG-treated group. Vestibular dysfunction was observed in the tail-hanging and swimming tests, with significantly different severity scores and swimming times detected between the control and 150mg/kg KRG-treated group at the age of 12months (p<0.05). Mice treated with 500mg/kg KRG exhibited irritability and aggravated inner ear dysfunction. Histological observation supported the findings of hearing and vestibular function defects. In conclusion, C57BL/6 mice showed early-onset hearing loss and progressive vestibular dysfunction with aging, which were delayed by treatment with 150mg/kg KRG. However, 500mg/kg KRG treatment may induce aggressive behavior.
authors: Department of Otolaryngology, Ajou University School of Medicine, Suwon, Republic of Korea.
authors: Chunjie
authors: C
authors: Tian
authors: Department of Otolaryngology, Ajou University School of Medicine, Suwon, Republic of Korea.
authors: Yeon Ju
authors: YJ
authors: Kim
authors: Department of Otolaryngology, Ajou University School of Medicine, Suwon, Republic of Korea.
authors: Hye Jin
authors: HJ
authors: Lim
authors: Department of Otolaryngology, Ajou University School of Medicine, Suwon, Republic of Korea.
authors: Young Sun
authors: YS
authors: Kim
authors: Department of Otolaryngology, Ajou University School of Medicine, Suwon, Republic of Korea.
authors: Hun Yi
authors: HY
authors: Park
authors: Department of Otolaryngology, Ajou University School of Medicine, Suwon, Republic of Korea. Electronic address: yhc@ajou.ac.kr.
authors: Yun-Hoon
authors: YH
authors: Choung
mesh_terms: D000375:Aging / Q000187:drug effects; D000818:Animals; D045304:Cytochromes c / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D006198:Hair Cells, Auditory / Q000187:drug effects / Q000648:ultrastructure; D034381:Hearing Loss / Q000378:metabolism / Q000517:prevention & control*; D008297:Male; D055670:Medicine, Korean Traditional; D008810:Mice, Inbred C57BL; D005894:Panax; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D011897:Random Allocation; D015837:Vestibular Diseases / Q000378:metabolism / Q000517:prevention & control*; D051020:bcl-X Protein / Q000378:metabolism
chemical_list: C494812:Bcl2l1 protein, mouse; D010936:Plant Extracts; D051020:bcl-X Protein; D045304:Cytochromes c
keywords: Aging; Hearing loss; Korean red ginseng; Prevention; Vestibular dysfunction