title: Identification of microRNAs as potential biomarker for gastric cancer by system biological analysis.
abstract: Gastric cancers (GC) have the high morbidity and mortality rates worldwide and there is a need to identify sufficiently sensitive biomarkers for GC. MicroRNAs (miRNAs) could be promising potential biomarkers for GC diagnosis. We employed a systematic and integrative bioinformatics framework to identify GC-related microRNAs from the public microRNA and mRNA expression dataset generated by RNA-seq technology. The performance of the 17 candidate miRNAs was evaluated by hierarchal clustering, ROC analysis, and literature mining. Fourteen have been found to be associated with GC and three microRNAs (miR-211, let-7b, and miR-708) were for the first time reported to associate with GC and may be used for diagnostic biomarkers for GC.
authors: Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China ; Taicang Center for Translational Bioinformatics Center for Systems Biology, Taicang 215400, China.
authors: Wenying
authors: W
authors: Yan
authors: Department of Pathology, Soochow University School of Medicine, Suzhou 215123, China.
authors: Shouli
authors: S
authors: Wang
authors: Center for Systems Biology, Soochow University, No. 1 Shizi Street, Suzhou 215006, China.
authors: Zhandong
authors: Z
authors: Sun
authors: Center for Systems Biology, Soochow University, No. 1 Shizi Street, Suzhou 215006, China.
authors: Yuxin
authors: Y
authors: Lin
authors: School of Chemistry, Biology and Material Engineering, Suzhou University of Science and Technology, Suzhou 215011, China.
authors: Shengwei
authors: S
authors: Sun
authors: Center for Systems Biology, Soochow University, No. 1 Shizi Street, Suzhou 215006, China ; School of Chemistry, Biology and Material Engineering, Suzhou University of Science and Technology, Suzhou 215011, China.
authors: Jiajia
authors: J
authors: Chen
authors: Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
authors: Weichang
authors: W
authors: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism; D016000:Cluster Analysis; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D053263:Gene Regulatory Networks; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012372:ROC Curve; D013274:Stomach Neoplasms / Q000235:genetics*; D049490:Systems Biology / Q000379:methods*
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs; D012333:RNA, Messenger