title: Evaluation of the ovarian reserve function in patients with metabolic syndrome in relation to healthy controls and different age groups.
abstract: OBJECTIVE
  To evaluate the ovarian reserve function in female patients with metabolic syndrome (MetS).
  
  
  METHODS
  This study evaluated 136 subjects, 67 with MetS and 69 controls. Subjects were divided into three age groups. Group I included 49 subjects aged 20-29 years, 22 with MetS and 27 controls; group II included 45 subjects aged 30-39 years, 22 with MetS and 23 controls; and group III included 42 subjects aged 40-49 years, 23 with MetS and 19 controls. Demographic characteristics, anthropometrics, blood biochemistry, and gonadotrophic hormones were compared as total ovarian volume and antral follicle count on ovarian transvaginal ultrasonography.
  
  
  RESULTS
  Serum levels of FSH, LH, E2 and progesterone were similar in the MetS and control groups, while testosterone levels were significantly higher in MetS patients than controls, both in the overall population (p = 0.024) and in those aged 20-29 years (p = 0.018). Total ovarian volume was significantly lower in MetS patients than controls, in both the overall population (p = 0.003) and those aged 20-29 years (p = 0.018), while antral follicle counts were similar. Ovarian volume correlated positively with antral follicle count (AFC) (r = 0.37; p < 0.001) and negatively with age (r = 0.34; p < 0.001) and FSH concentration (r = 0.21; p = 0.013). AFC was negatively correlated with age (r = 0.36; p < 0.001).
  
  
  CONCLUSIONS
  Ovarian reserve function is significantly lower in MetS patients than in healthy control subjects, particularly in women aged 20-29 years.
authors: Endocrinology and Metabolic Disease, Aksaray State Hospital, Aksaray, Turkey.
authors: Fevzi
authors: F
authors: Balkan
authors: Radiology Department, Aksaray State Hospital, Aksaray, Turkey.
authors: Nurcan
authors: N
authors: Cetin
authors: Endocrinology and Metabolic Disease, Dr. Ersin Arslan State Hospital, Gaziantep, Turkey.
authors: Celil Alper
authors: CA
authors: Usluogullari
authors: Endocrinology and Metabolic Disease, Aksaray State Hospital, Aksaray, Turkey.
authors: Oguz Kaan
authors: OK
authors: Unal
authors: Gynecology and Obstetrics Department, Cengiz Gokcek State Hospital, Gaziantep, Turkey.
authors: Betul
authors: B
authors: Usluogullari
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D024821:Metabolic Syndrome / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology*; D008875:Middle Aged; D065851:Ovarian Reserve; D010053:Ovary / Q000000981:diagnostic imaging / Q000473:pathology; D011859:Radiography; D014421:Turkey; D055815:Young Adult
chemical_list: D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
keywords: Antral follicle; Gonadotropins; Metabolic syndrome; Obesity; Ovarian reserve; Ovarian volume