title: CD57 expression in incidental, clinically manifest, and metastatic carcinoma of the prostate.
abstract: OBJECTIVE
  CD57 is normally found on NK-cells, but little is known about its expression in prostatic tissue.
  
  
  METHODS
  We investigated CD57 expression by immunohistochemistry using tissue microarrays containing 3262 prostate cancers (PCa), lymph node metastases, and benign prostatic tissue. The results were compared with clinical and pathological parameters.
  
  
  RESULTS
  Overall, 87% of PCa showed a moderate or strong expression of CD57. There was no significant difference to corresponding benign prostatic tissue. CD57 was increasingly lost from incidental over clinically manifest cancers to metastases. It correlated significantly with Gleason grade and pT-category, but not with PSA tissue expression. Loss of CD57 expression was an independent risk factor for PSA recurrence after prostatectomy in a multivariate Cox regression analysis. In standard sections, CD57 expression was heterogeneous, especially in large, high-grade PCa.
  
  
  CONCLUSIONS
  There is a peculiar expression of CD57 in PCa and benign prostatic tissue. CD57 loss is associated with tumor dedifferentiation and tumor size. However, the use of this marker for prognostic purposes is hampered by its heterogeneous expression.
authors: Institute of Pathology, University Medicine Rostock, Strempelstraße 14, 18055 Rostock, Germany.
authors: Holger
authors: H
authors: Wangerin
authors: Institute of Pathology, University of Bonn, Germany.
authors: Glen
authors: 0000-0003-4149-5487
authors: G
authors: Kristiansen
authors: Martini Clinic, University Hospital Hamburg-Eppendorf, Germany.
authors: Thorsten
authors: T
authors: Schlomm
authors: Department of Urology, Charité University Hospital Berlin and Berlin Institute for Urologic Research, Germany.
authors: Carsten
authors: C
authors: Stephan
authors: Institute of Pathology, Stendal, Germany.
authors: Sven
authors: S
authors: Gunia
authors: Institute of Pathology, University Medicine Rostock, Strempelstraße 14, 18055 Rostock, Germany.
authors: Annette
authors: A
authors: Zimpfer
authors: Institute of Pathology, University of Heidelberg, Germany.
authors: Wilko
authors: W
authors: Weichert
authors: Institute of Pathology, University Hospital Hamburg-Eppendorf, Germany.
authors: Guido
authors: G
authors: Sauter
authors: Institute of Pathology, University Medicine Rostock, Strempelstraße 14, 18055 Rostock, Germany.
authors: Andreas
authors: A
authors: Erbersdobler
mesh_terms: D018959:CD57 Antigens / Q000378:metabolism*; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008297:Male; D011379:Prognosis; D011467:Prostate / Q000378:metabolism / Q000473:pathology; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D046888:Tissue Array Analysis
chemical_list: D018959:CD57 Antigens