title: Antiprotozoal activity of 8-acyl and 8-alkyl incomptine A analogs.
abstract: The activities of 11 C-8-O-acyl and alkyl analogs of the antiprotozoal sesquiterpene lactone, incomptine A (1) against Entamoeba histolytica and Giardia lamblia, were determined. Here, the effects of different lengths and amounts of branching of the acyl and alkyl groups on the antiprotozoal activity of the synthesized incomptine A-analogs are reported.
authors: Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, C.P. 04510 México D.F., Mexico.
authors: Elihú
authors: E
authors: Bautista
authors: Unidad de Investigación Médica en Farmacología, UMAE Hospital de Especialidades, 2° Piso CORSE, Centro Médico Nacional Siglo XXI, IMSS, Av. Cuahutemoc 330, Col. Doctores, C.P. 06725 México D.F., Mexico.
authors: Fernando
authors: F
authors: Calzada
authors: Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, C.P. 04510 México D.F., Mexico.
authors: Fabiola A
authors: FA
authors: López-Huerta
authors: Unidad de Investigación Médica en Enfermedades Infecciosas y Parasitarias, UMAE Hospital de Pediatría, Centro Médico Nacional Siglo XXI, IMSS, Av. Cuahutemoc 330, Col. Doctores, C.P. 06725 México D.F., Mexico.
authors: Lilian
authors: L
authors: Yépez-Mulia
authors: Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, C.P. 04510 México D.F., Mexico. Electronic address: ahortega@unam.mx.
authors: Alfredo
authors: A
authors: Ortega
mesh_terms: D000981:Antiprotozoal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004748:Entamoeba histolytica / Q000187:drug effects*; D016829:Giardia lamblia / Q000187:drug effects*; D008968:Molecular Conformation; D021261:Parasitic Sensitivity Tests; D012717:Sesquiterpenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000981:Antiprotozoal Agents; D012717:Sesquiterpenes; C585422:incomptine A
keywords: Antiprotozoal activity; Entamoeba histolytica; Giardia lamblia; Incomptine A analogs; Sesquiterpene lactones