title: Insulin resistance and its relationship with high molecular weight adiponectin in adolescents with polycystic ovary syndrome and a maternal history of polycystic ovary syndrome.
abstract: OBJECTIVE
  To assess the rate of insulin resistance (IR) and the relationship between IR and high molecular weight (HMW) adiponectin in normal weight adolescents with polycystic ovary syndrome (PCOS) and a maternal history of PCOS.
  
  
  METHODS
  Case-controlled study.
  
  
  METHODS
  Adolescent clinic of a teaching and research hospital.
  
  
  METHODS
  Forty normal weight adolescents with PCOS and a maternal history of PCOS and 40 normo-ovulatory age- and body mass index (BMI)-matched controls.
  
  
  METHODS
  A 75-g oral glucose tolerance test (OGTT) was performed for each participant.
  
  
  METHODS
  Homeostasis model assessment of IR and HMW adiponectin.
  
  
  RESULTS
  There were no statistically significant differences between the PCOS and control groups in terms of fasting glucose, fasting insulin, and lipid parameters. Although total and free T were significantly higher, HMW adiponectin levels were significantly lower in the PCOS group compared with the control group. When the PCOS group was compared according to the IR, the HMW adiponectin level was significantly lower in the adolescents with PCOS and IR. The adolescents with PCOS and biochemical hyperandrogenemia had significantly lower HMW adiponectin levels and significantly higher homeostasis model assessment of IR score compared with the adolescents with PCOS and normoandrogenemia.
  
  
  CONCLUSIONS
  The adolescents with PCOS had a significantly increased rate of IR without clinical findings of metabolic disorders or obesity. The HMW adiponectin levels were negatively correlated with IR.
authors: Kovancılar State Hospital, Elazıg, Turkey.
authors: Sevil
authors: S
authors: Cankaya
authors: Department of Obstetrics and Gynecology, Etlik Zubeyde Hanim Women's Health Teaching and Research Hospital, Ankara, Turkey. Electronic address: demirberfu@gmail.com.
authors: Berfu
authors: B
authors: Demir
authors: Department of Obstetrics and Gynecology, Etlik Zubeyde Hanim Women's Health Teaching and Research Hospital, Ankara, Turkey.
authors: Sezin Erturk
authors: SE
authors: Aksakal
authors: Department of Obstetrics and Gynecology, Etlik Zubeyde Hanim Women's Health Teaching and Research Hospital, Ankara, Turkey.
authors: Berna
authors: B
authors: Dilbaz
authors: Department of Medical Biochemistry, Gazi University School of Medicine, Ankara, Turkey.
authors: Canan
authors: C
authors: Demirtas
authors: Kosovo Pay Hospital and IVF Clinic, Kosovo.
authors: Umit
authors: U
authors: Goktolga
mesh_terms: D052242:Adiponectin / Q000097:blood* / Q000737:chemistry; D000293:Adolescent; D016022:Case-Control Studies; D016241:Child of Impaired Parents; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance; D008970:Molecular Weight; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000378:metabolism*; D055815:Young Adult
chemical_list: D052242:Adiponectin
keywords: High molecular weight adiponectin; insulin resistance; polycystic ovary syndrome