title: Epidemiology of neurodegenerative diseases in sub-Saharan Africa: a systematic review.
abstract: BACKGROUND
  Sub-Saharan African (SSA) countries are experiencing rapid transitions with increased life expectancy. As a result the burden of age-related conditions such as neurodegenerative diseases might be increasing. We conducted a systematic review of published studies on common neurodegenerative diseases, and HIV-related neurocognitive impairment in SSA, in order to identify research gaps and inform prevention and control solutions.
  
  
  METHODS
  We searched MEDLINE via PubMed, 'Banque de Données de Santé Publique' and the database of the 'Institut d'Epidemiologie Neurologique et de Neurologie Tropicale' from inception to February 2013 for published original studies from SSA on neurodegenerative diseases and HIV-related neurocognitive impairment. Screening and data extraction were conducted by two investigators. Bibliographies and citations of eligible studies were investigated.
  
  
  RESULTS
  In all 144 publications reporting on dementia (n = 49 publications, mainly Alzheimer disease), Parkinsonism (PD, n = 20), HIV-related neurocognitive impairment (n = 47), Huntington disease (HD, n = 19), amyotrophic lateral sclerosis (ALS, n = 15), cerebellar degeneration (n = 4) and Lewy body dementia (n = 1). Of these studies, largely based on prevalent cases from retrospective data on urban populations, half originated from Nigeria and South Africa. The prevalence of dementia (Alzheimer disease) varied between <1% and 10.1% (0.7% and 5.6%) in population-based studies and from <1% to 47.8% in hospital-based studies. Incidence of dementia (Alzheimer disease) ranged from 8.7 to 21.8/1000/year (9.5 to 11.1), and major risk factors were advanced age and female sex. HIV-related neurocognitive impairment's prevalence (all from hospital-based studies) ranged from <1% to 80%. Population-based prevalence of PD and ALS varied from 10 to 235/100,000, and from 5 to 15/100,000 respectively while that for Huntington disease was 3.5/100,000. Equivalent figures for hospital based studies were the following: PD (0.41 to 7.2%), ALS (0.2 to 8.0/1000), and HD (0.2/100,000 to 46.0/100,000).
  
  
  CONCLUSIONS
  The body of literature on neurodegenerative disorders in SSA is large with regard to dementia and HIV-related neurocognitive disorders but limited for other neurodegenerative disorders. Shortcomings include few population-based studies, heterogeneous diagnostic criteria and uneven representation of countries on the continent. There are important knowledge gaps that need urgent action, in order to prepare the sub-continent for the anticipated local surge in neurodegenerative diseases.
authors: Alain
authors: A
authors: Lekoubou
authors: Justin B
authors: JB
authors: Echouffo-Tcheugui
authors: Department of Medicine, University of Cape Town, Cape Town, South Africa. andre.kengne@mrc.ac.za.
authors: Andre P
authors: AP
authors: Kengne
mesh_terms: D017954:Africa South of the Sahara / Q000453:epidemiology; D002493:Central Nervous System Diseases / Q000453:epidemiology*; D003072:Cognition Disorders / Q000453:epidemiology* / Q000209:etiology; D003704:Dementia / Q000453:epidemiology*; D005260:Female; D015658:HIV Infections / Q000150:complications; D006801:Humans; D008297:Male; D019636:Neurodegenerative Diseases / Q000453:epidemiology*