title: Treatment of c-kit positive adenoid cystic carcinoma of the tongue: A case report.
abstract: Adenoid cystic carcinoma (ACC) or 'cylindroma' is a malignant tumor that often occurs in the areas of the head and neck, affecting the secretory glands and the major and minor salivary glands. The present study describes a case of a patient who presented with a posterior tongue lesion. The case is of a 71-year-old female with an asymptomatic volume growth of the posterior left tongue perceived 8 months prior, and neoplastic cells positive for c-kit. A computed tomography of the head and neck showed asymmetry of the base of the tongue, which was enlarged in the left portion. A physical examination revealed a nodule on the posterior left tongue of ~3 cm in diameter, while the cervical lymph node chain had a normal size and consistency. Surgical exeresis of the tongue lesion and cervical lymph node dissection were performed. Subsequent to surgical removal of the cancer cells and adjuvant radiotherapy, the patient showed excellent health, although the follow-up remains in progress. ACC, one of the most biologically destructive tumors of the head and neck, is locally aggressive and gives rise to distant metastases. The tongue is the place of origin in 3.4-17.1% of cases. The treatment for ACC consists of primary surgical resection with adjuvant radiotherapy. To prevent the risk for distant metastasis, it is necessary to remove the first echelon nodes and monitor the patient with a long-term follow-up.
authors: Ear, Nose and Throat Department, University 'Federico II', Naples I-80138, Italy.
authors: Massimo
authors: M
authors: Mesolella
authors: Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples I-80138, Italy.
authors: Amalia
authors: A
authors: Luce
authors: Ear, Nose and Throat Department, University 'Federico II', Naples I-80138, Italy.
authors: Anna
authors: A
authors: Marino
authors: Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples I-80138, Italy.
authors: Michele
authors: M
authors: Caraglia
authors: Ear, Nose and Throat Department, University 'Federico II', Naples I-80138, Italy.
authors: Filippo
authors: F
authors: Ricciardiello
authors: Ear, Nose and Throat Department, University 'Federico II', Naples I-80138, Italy.
authors: Maurizio
authors: M
authors: Iengo
keywords: adenoid cystic carcinoma; c-kit; cylindroma; lymph nodes; salivary gland neoplasm; tongue