title: Magnetically responsive smart nanoparticles for cancer treatment with a combination of magnetic hyperthermia and remote-control drug release.
abstract: We report the synthesis of smart nanoparticles (NPs) that generate heat in response to an alternating current magnetic field (ACMF) and that sequentially release an anticancer drug (doxorubicin, DOX). We further study the in vivo therapeutic efficacy of the combination of magnetic hyperthermia (MHT) and chemotherapy using the smart NPs for the treatment of multiple myeloma. The smart NPs are composed of a polymer with a glass-transition temperature (T g) of 44°C, which contains clustered Fe3O4 NPs and DOX. The clustered Fe3O4 NPs produce heat when the ACMF is applied and rise above 44°C, which softens the polymer phase and leads to the release of DOX. The combination of MHT and chemotherapy using the smart NPs destroys cancer cells in the entire tumor and achieves a complete cure in one treatment without the recurrence of malignancy. Furthermore, the smart NPs have no significant toxicity.
authors: 1. Department of Anatomy and Cell Biology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan. E-mail: hayashi@tokushima-u.ac.jp ; 5. Division of Nanomaterials Science, EcoTopia Science Institute, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan.
authors: Koichiro
authors: K
authors: Hayashi
authors: 1. Department of Anatomy and Cell Biology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan. E-mail: hayashi@tokushima-u.ac.jp.
authors: Michihiro
authors: M
authors: Nakamura
authors: 2. Division of Transfusion Medicine, Tokushima University Hospital 2-50-1 Kuramoto-cho, Tokushima, 770-0042, Japan;
authors: Hirokazu
authors: H
authors: Miki
authors: 3. Department of Internal Medicine, Tokushima Prefectural Central Hospital, 1-10-3 Kuramoto-cho, Tokushima, 770-0042, Japan;
authors: Shuji
authors: S
authors: Ozaki
authors: 4. Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Medical Sciences, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan;
authors: Masahiro
authors: M
authors: Abe
authors: 4. Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Medical Sciences, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan;
authors: Toshio
authors: T
authors: Matsumoto
authors: 5. Division of Nanomaterials Science, EcoTopia Science Institute, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan.
authors: Wataru
authors: W
authors: Sakamoto
authors: 5. Division of Nanomaterials Science, EcoTopia Science Institute, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan.
authors: Toshinobu
authors: T
authors: Yogo
authors: 1. Department of Anatomy and Cell Biology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan. E-mail: hayashi@tokushima-u.ac.jp.
authors: Kazunori
authors: K
authors: Ishimura
mesh_terms: D000818:Animals; D001835:Body Weight; D065546:Drug Liberation; D005260:Female; D006979:Hyperthermia, Induced; D060328:Magnetic Phenomena; D051379:Mice; D053758:Nanoparticles / Q000627:therapeutic use*; D009369:Neoplasms / Q000628:therapy*; D009929:Organ Size; D017216:Telemedicine / Q000379:methods*
keywords: alternating current magnetic field; cancer cells; smart nanoparticles