title: Status of immunity against PVB19 in HIV-infected patients according to CD4(+) cell count, and antiretroviral therapy regimen groups.
abstract: BACKGROUND
  Human Parvovirus B19 (PVB19) is among the aetiology of aplastic crisis in human immunodeficiency virus (HIV)-infected patients. Several studies have indicated the importance of an infection agent in bringing about complications in immuno-compromised patients. The current study aims to determine the seroprevalence of IgM and IgG antibodies to PVB19 among HIV-positive patients and its association with clinical and epidemiological factors.
  
  
  METHODS
  In a case control study, 90 HIV-positive patients were compared with 90 sex and age matched healthy controls in terms of anti-PVB19 IgG and IgM along with other primary clinical and laboratory features.
  
  
  RESULTS
  The overall prevalence of positive anti-PVB19 IgG among HIV patients and controls were 81.1% and 28.9%, respectively (P < 0.001). None of the subjects showed positive results for anti-PVB19 IgM. Patients with CD4(+) cell count <200 showed higher seroprevalence of positive anti-PVB19 IgG which did not reach statistically significant. However, anti-PVB19 IgG seropositivity differed significantly between HIV patients on different regimens of antiretroviral therapy (ART) (P < 0.05).
  
  
  CONCLUSIONS
  Immunity against PVB19 is more prevalent among HIV-positive patients compared to healthy controls. However, positive HIV status is not associated with acute PVB19 infection. The presence of anti-PVB19 IgG does not necessarily protect the body from further complications like anaemia. Given the results of the study, AIDS patients are recommended to undergo screening for parvovirus antibody in order to prevent complications like aplastic anaemia.
authors: Departments of Pathology, Infectious Diseases, Imam Hospitals Complex, Tehran University of Medical Science, Tehran, Iran.
authors: Alireza
authors: A
authors: Abdollahi
authors: Departments of Pathology, Infectious Diseases, Imam Hospitals Complex, Tehran University of Medical Science, Tehran, Iran.
authors: Saeed
authors: S
authors: Shoar
authors: Departments of Pathology, Infectious Diseases, Imam Hospitals Complex, Tehran University of Medical Science, Tehran, Iran.
authors: Sara
authors: S
authors: Sheikhbahaei
authors: Departments of Pathology, Infectious Diseases, Imam Hospitals Complex, Tehran University of Medical Science, Tehran, Iran.
authors: Behnaz
authors: B
authors: Mahdaviani
authors: Departments of Pathology, Infectious Diseases, Imam Hospitals Complex, Tehran University of Medical Science, Tehran, Iran.
authors: Mehrnaz
authors: M
authors: Rasoulinejad
keywords: ART regimen; human immunodeficiency virus; immunity; parvovirus B19