title: Endoscopic submucosal dissection: experience in an Australian tertiary center.
abstract: BACKGROUND
  Endoscopic submucosal dissection (ESD) is a technique foren blocresection of superficial tumors of the gastrointestinal tract. In contrast to Japan and other Asian countries, few data are available in Western countries. The objective of the current study was to evaluate the experience of ESD in a single Australian tertiary center.
  
  
  METHODS
  The patient features, outcomes and complications of ESD of 20 lesions in 18 patients at a single center between 2008 and 2012, were evaluated retrospectively.
  
  
  RESULTS
  Twenty lesions, in 18 patients of median age 69.5 years, were resected with ESD. Ten patients had gastric lesions (of whom two had two synchronous lesions), four patients had rectal lesions, one had a colonic lesion, one had a duodenal lesion and two had esophageal lesions. The median (range) lesion size was 2.5 (0.5-6.5) cm. In the entire cohort,en blocresection occurred in 80% cases and complete histological resection was achieved in 60% cases. Significant bleeding requiring repeat endoscopy and transfusion occurred in two cases and microscopic perforation occurred in 1 case. Surgery for unsuccessful ESD was pursued without complication in 6 cases. There were two recurrences during follow up of median 36 months, both of which occurred in cases of gastric ESD and one of which (carcinoid) occurred after surgery.
  
  
  CONCLUSIONS
  ESD appears feasible in an Australian population. It should however be contemplated in carefully selected patients whilst there is refinement of pre-treatment diagnosis, the ESD technique and the management of its complications.
authors: Department of Gastroenterology, East Kent Hospitals University Foundation Trust, UK (Prayman T. Sattianayagam) ; Department of Gastroenterology, St. Vincent's Hospital, Melbourne, Australia (Prayman T. Sattianayagam, Paul V. Desmond, Chatura Jayasekera, Robert Y. Chen).
authors: Prayman T
authors: PT
authors: Sattianayagam
authors: Department of Gastroenterology, St. Vincent's Hospital, Melbourne, Australia (Prayman T. Sattianayagam, Paul V. Desmond, Chatura Jayasekera, Robert Y. Chen).
authors: Paul V
authors: PV
authors: Desmond
authors: Department of Gastroenterology, St. Vincent's Hospital, Melbourne, Australia (Prayman T. Sattianayagam, Paul V. Desmond, Chatura Jayasekera, Robert Y. Chen).
authors: Chatura
authors: C
authors: Jayasekera
authors: Department of Gastroenterology, St. Vincent's Hospital, Melbourne, Australia (Prayman T. Sattianayagam, Paul V. Desmond, Chatura Jayasekera, Robert Y. Chen).
authors: Robert Y
authors: RY
authors: Chen
keywords: Endoscopic submucosal dissection; en bloc resection; perforation