title: Anti-quorum sensing activity of AgCl-TiO2 nanoparticles with potential use as active food packaging material.
abstract: OBJECTIVE
  To study the anti-quorum sensing (anti-QS) activity of AgCl-TiO2 nanoparticles (ATNPs) and its mechanism.
  
  
  RESULTS
  Anti-QS activity of ATNPs was evaluated using the bacterial model Chromobacterium violaceum. Silver present in ATNPs significantly reduced violacein production in a concentration-dependent manner, indicating inhibition of QS. Anti-QS activity was confirmed by the absence of signalling molecule, oxo-octanoyl homoserine lactone during growth in the presence of ATNPs. TiO2 acted as a good supporting matrix facilitating controlled release of silver with prolonged residual activity.
  
  
  CONCLUSIONS
  ATNPs are proposed as QS inhibitors with potential for use as an antipathogenic but nontoxic bioactive material. Although silver is well known for its bioactive potential of antibacterial, antifungal and antiviral properties, this study adds further note on its anti-QS activity and its potential use in food packaging industry.
  
  
  CONCLUSIONS
  Food spoilage is a major socio-economic problem, and the potential role of QS in food spoilage and food safety has been indicated. Anti-QS materials such as ATNPs are proposed as efficient models for controlling food spoilage. ATNPs incorporated in food packaging materials could play an important role in food preservation and ensure safety of food by prolonging their shelf life.
authors: Birla Institute of Technology & Science Pilani K K Birla Goa Campus, Zuarinagar, Goa, India.
authors: K
authors: K
authors: Naik
authors: M
authors: M
authors: Kowshik
mesh_terms: D054742:Acyl-Butyrolactones / Q000032:analysis / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018441:Biofilms / Q000254:growth & development; D002861:Chromobacterium / Q000187:drug effects* / Q000502:physiology; D018857:Food Packaging; D053758:Nanoparticles; D053038:Quorum Sensing / Q000187:drug effects*; D018030:Silver Compounds / Q000494:pharmacology*; D014025:Titanium / Q000494:pharmacology*
chemical_list: D054742:Acyl-Butyrolactones; D000900:Anti-Bacterial Agents; D018030:Silver Compounds; C009495:titanium dioxide; D014025:Titanium; C037548:silver chloride
keywords: AgCl-TiO2; Chromobacterium violaceum; N-acyl homoserine lactone; anti-quorum sensing activity; food packaging