title: Clinical manifestations and imaging characteristics of gliomatosis cerebri with pathological confirmation.
abstract: OBJECTIVE
  To explore the clinical manifestations and imaging characteristics of gliomatosis cerebri to raise the awareness and improve its diagnostic accuracy for patients.
  
  
  METHODS
  Clinical data, imaging characteristics and pathological examination of 12 patients with GC from Jan., 2008 to Jan., 2012 were analyzed retrospectively.
  
  
  RESULTS
  Patients with GC were clinically manifested with headache, vomiting, repeated seizures, fatigue and unstable walking, most of whom had more than 2 lesions involving in parietal lobe, followed by temporal lobe, frontal lobe, periventricular white matter and corpus callosum. Magnetic resonance imaging (MRI) showed diffuse distribution, T1-weighted images (T1WI) with equal and low signals and T2-weighted images (T2WI) with bilateral symmetrical high diffuse signals. There was no reinforcement by enhancement scanning and signals were different in diffusion-weighted images (DWI). The higher the tumor staging, the stronger the signals. Pathological examination showed neuroastrocytoma in which tumor tissues were manifested by infiltrative growth in blood vessels and around neurons.
  
  
  CONCLUSIONS
  In clinical diagnosis of GC, much attention should be paid to the diffuse distribution of imaging characteristics, incomplete matching between clinical and imaging characteristics and confirmation by combining with histopathological examination.
authors: Department of Neurosurgery, Affiliated Hospital of Taishan Medical University, Tai'an, China E-mail : Lmh09910991@126.com.
authors: Chun-Pu
authors: CP
authors: Zhang
authors: Hua-Qing
authors: HQ
authors: Li
authors: Wei-Tao
authors: WT
authors: Zhang
authors: Ming-Hui
authors: MH
authors: Liu
authors: Wen-Jing
authors: WJ
authors: Pan
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009367:Neoplasm Staging / Q000379:methods; D018302:Neoplasms, Neuroepithelial / Q000473:pathology*; D012189:Retrospective Studies