title: Management of radicular cysts using platelet-rich fibrin and bioactive glass: a report of two cases.
abstract: Platelet-rich fibrin (PRF) created by Choukroun's protocol concentrates most platelets and leukocytes from a blood harvest into a single autologous fibrin biomaterial. However, no current data is available concerning the use of PRF for the treatment of periapical lesions. Two cases of radicular cysts were reported using an interdisciplinary approach, including regular endodontic therapy followed by surgical management with PRF and bioactive glass. Two cases of radicular cysts presented as an incidental radiographic finding, appearing as an apical radiolucency with well-circumscribed sclerotic borders. After regular endodontic retreatment, cystic lining/granulation tissues were enucleated and the periradicular bony defect was grafted using PRF and bioactive glass. Then, PRF was applied to serve as a membrane over the grafted defects. Recall periapical radiographs of Case 1 and cone beam computer tomography of Case 2 showed satisfactory healing of the periapical pathosis. In Case 2, the bony defect appeared completely healed at 4 months surgical reentry and the new bone was clinically very dense and mature. The results of these case reports show that the combination of PRF and bioactive glass is an effective modality of regenerative treatment for radicular cysts.
authors: School of Dentistry, Chung Shan Medical University, Taichung, Taiwan.
authors: Jiing-Huei
authors: JH
authors: Zhao
authors: Department of Oral Pathology, Chung Shan Medical University Hospital, Taichung, Taiwan.
authors: Chung-Hung
authors: CH
authors: Tsai
authors: School of Dentistry, Chung Shan Medical University, Taichung, Taiwan; Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan. Electronic address: cyc@csmu.edu.tw.
authors: Yu-Chao
authors: YC
authors: Chang
mesh_terms: D000328:Adult; D001792:Blood Platelets; D005260:Female; D005337:Fibrin / Q000627:therapeutic use*; D005898:Glass; D006801:Humans; D011842:Radicular Cyst / Q000000981:diagnostic imaging / Q000601:surgery / Q000628:therapy*; D011859:Radiography
chemical_list: D005337:Fibrin
keywords: bioactive glass; platelet-rich fibrin; radicular cyst; tissue regeneration