title: Anticancer activities of sulindac in prostate cancer cells associated with c-Jun NH2-terminal kinase 1/β-catenin signaling.
abstract: The non-steroidal anti-inflammatory agent, sulindac, has shown strong effects on cancer prevention in colorectal cancers, however, its anticancer activities on prostate cancer remain unclear. In the current study, human prostate cancer cell lines, LNCaP and PC-3, were treated with various concentrations of sulindac and it was found that sulindac significantly inhibits prostate cancer cell proliferation and promotes cell apoptosis in a dose- and time-dependent manner. Further studies revealed that sulindac significantly induces c-Jun NH2-terminal kinase (JNK) 1 phosphorylation and inhibits β-catenin at the transcriptional and post-transcriptional levels. In conclusion, by targeting the JNK1/β-catenin signaling pathway, sulindac may present a potential preventive or therapeutic agent for treatment of patients with prostate cancer.
authors: Department of Urology, Xinxiang Central Hospital, The Teaching Hospital of Xinxiang Medical University, Xinxiang, Henan 453000, P.R. China.
authors: Jun
authors: J
authors: DU
authors: Department of Laboratory Medicine, Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China.
authors: Yongchen
authors: Y
authors: Guo
authors: Department of Microbiology, Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China.
authors: Yonghua
authors: Y
authors: Bao
authors: Department of Pathology, University of Illinois at Chicago, Chicago, IL 60612, USA.
authors: Mengtao
authors: M
authors: Xing
authors: Department of Pathology, University of Illinois at Chicago, Chicago, IL 60612, USA.
authors: Abeer M
authors: AM
authors: Mahmoud
authors: Department of Neurology, Xinxiang Central Hospital, The Teaching Hospital of Xinxiang Medical University, Xinxiang, Henan 453000, P.R. China.
authors: Zhenyong
authors: Z
authors: Che
authors: Department of Pathology, Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China.
authors: Zhiguo
authors: Z
authors: Chen
authors: Department of Pathology, University of Illinois at Chicago, Chicago, IL 60612, USA ; Department of Pathology, Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China.
authors: Wancai
authors: W
authors: Yang
keywords: c-Jun NH2-terminal kinase 1; prostate cancer; sulindac; β-catenin