title: Shinjulactone O, a new quassinoid from the root bark of Ailanthus altissima.
abstract: A new quassinoid, shinjulactone O (1), and seven known quassinoids, were isolated from the 50% ethanol extract of the root bark of Ailanthus altissima. The structures of these compounds were determined based on spectroscopic methods including UV, IR, HR-ESI-MS, 1D and 2D NMR. Their cytotoxic activities were evaluated on the tumour cell lines MCF-7, MDA-MB-231, HepG2 and A549 cells, as well as the normal HUVEC line in vitro. Compounds 1-8 exhibited different levels of inhibitory activity against tumour cell lines.
authors: a Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University , Guangzhou 510632 , P.R. China.
authors: Xiao-Lin
authors: XL
authors: Yang
authors: Yong-Liang
authors: YL
authors: Yuan
authors: Dong-Mei
authors: DM
authors: Zhang
authors: Fei
authors: F
authors: Li
authors: Wen-Cai
authors: WC
authors: Ye
mesh_terms: D032268:Ailanthus / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005260:Female; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects; D006801:Humans; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D036702:Quassins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D036702:Quassins; C000593551:shinjulactone O
keywords: Ailanthus altissima; cytotoxicity; quassinoid; shinjulactone O