title: Aerobic copper-catalyzed oxidative [6C+1C] annulation: an efficient route to seven-membered carbocycles.
abstract: It has been revealed for the first time that co-promoted by CuCl and NaH in the presence of molecular oxygen (air), the reaction of dicinnamoyl ketene dithioacetals as the acyclic C6 synthons with ethyl cyanoacetate gives functionalized seven-membered carbocycles. A mechanism is proposed involving a tandem Michael addition-intramolecular radical cyclization-benzyl C(sp(3))-H bond oxidation.
authors: Department of Chemistry, Northeast Normal University, Changchun 130024, China. xuxx677@nenu.edu.cn liuqun@nenu.edu.cn.
authors: Xiao
authors: X
authors: Liu
authors: Lingjuan
authors: L
authors: Zhang
authors: Xianxiu
authors: X
authors: Xu
authors: Shan
authors: S
authors: Wang
authors: Ling
authors: L
authors: Pan
authors: Qian
authors: Q
authors: Zhang
authors: Qun
authors: Q
authors: Liu
mesh_terms: D001593:Benzyl Compounds / Q000737:chemistry; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D006860:Hydrogen Bonding; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry*; D011083:Polycyclic Compounds / Q000737:chemistry*
chemical_list: D001593:Benzyl Compounds; D011083:Polycyclic Compounds; D003300:Copper; D010100:Oxygen