title: Mitogen-Activated Protein Kinase Phosphatase (MKP)-1 in Nervous System Development and Disease.
abstract: Mitogen-activated protein kinase phosphatase (MKP)-1 provides a negative feedback mechanism for regulating mitogen-activated protein kinase (MAPK) activity and thus a variety of cellular processes such as proliferation, differentiation, growth and apoptosis. MKP-1 is established as a central regulator of a variety of functions in the immune, metabolic and cardiovascular systems, and it is now increasingly acknowledged as having a role to play in the nervous system. It has been implicated in regulating processes of neuronal cell development and death as well as in glial cell function. Reduced MKP-1 levels have been observed in models of neurological conditions including Huntington's disease, multiple sclerosis, ischemia and cerebral hypoxia. It has also been suggested to have a role to play in psychiatric disorders such as major depressive disorder. Here, we discuss the role of MKP-1 in nervous system development and disease and examine current evidence providing insight into MKP-1 as a potential therapeutic target for various diseases of the central nervous system.
authors: Department of Anatomy and Neuroscience, University College Cork, Western Gate Building, Cork, Ireland.
authors: Louise M
authors: LM
authors: Collins
authors: Eric J
authors: EJ
authors: Downer
authors: André
authors: A
authors: Toulouse
authors: Yvonne M
authors: YM
authors: Nolan
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000201:enzymology* / Q000254:growth & development*; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000201:enzymology; D054638:Dual Specificity Phosphatase 1 / Q000096:biosynthesis*; D006801:Humans; D006816:Huntington Disease / Q000175:diagnosis / Q000201:enzymology; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000201:enzymology
chemical_list: D054638:Dual Specificity Phosphatase 1