title: GH and the cardiovascular system: an update on a topic at heart.
abstract: In this review, the importance of growth hormone (GH) for the maintenance of normal cardiac function in adult life is discussed. Physiological effects of GH and underlying mechanisms for interactions between GH and insulin-like growth factor I (IGF-I) and the cardiovascular system are covered as well as the cardiac dysfunction caused both by GH excess (acromegaly) and by GH deficiency in adult hypopituitary patients. In both acromegaly and adult GH deficiency, there is also increased cardiovascular morbidity and mortality possibly linked to aberrations in GH status. Finally, the status of the GH/IGF-I system in relation to heart failure and the potential of GH as a therapeutic tool in the treatment of heart failure are reviewed in this article.
authors: Laboratory of Experimental Endocrinology, Department of Internal Medicine, Sahlgrenska Academy, University of Gothenburg, Gröna Stråket 8, 413 45, Göteborg, Sweden, jorgen.isgaard@medic.gu.se.
authors: Jörgen
authors: J
authors: Isgaard
authors: Michele
authors: M
authors: Arcopinto
authors: Kristjan
authors: K
authors: Karason
authors: Antonio
authors: A
authors: Cittadini
mesh_terms: D002320:Cardiovascular Physiological Phenomena; D006321:Heart / Q000502:physiology*; D006331:Heart Diseases / Q000188:drug therapy; D019382:Human Growth Hormone / Q000502:physiology* / Q000627:therapeutic use; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D011994:Recombinant Proteins; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I