title: Low-income status is an important risk factor in North East Mexican patients with cystic fibrosis.
abstract: BACKGROUND. Factors such as environment, income status, as well as access to proper healthcare influence the survival and quality of life of people affected by chronic diseases including cystic fibrosis (CF). Survival factors in Mexican patients with CF have not been reported before, even when it has been estimated that this disease could not be negligible in the Mexican population. OBJECTIVE. To compare the influence of the mutant allele ΔF508 and environmental factors on the survival of Mexican CF patients. MATERIAL AND METHODS. We collected epidemiological data of 40 patients molecularly tested between 1987 and 2008 in the Clínica de Fibrosis Quística from the Hospital Universitario of the Universidad Autónoma de Nuevo León in Northeastern México. Kaplan-Meier plots and survival statistics were estimated and compared. RESULTS. Survival analysis revealed statistical significance for low-income status (p = 3.13 x 10-6), cor pulmonale (p = 0.00169), severe pulmonary disease (p = 0.00136), and BMI ≤15 kg/m2 (p = 0.00678). Statistical significance was not observed for the predominant allele ΔF508 considering two (p = 0.992), one (p = 0.503) or no (p = 0.403) mutant allele. CONCLUSIONS. Low income status was the most detrimental factor; followed by cor pulmonale, severe pulmonary disease and BMI ≤ 15 kg/m2 for the survival in North East Mexican patients with CF. Carrying the ΔF508 allele did not influence survival.
authors: Departamento de Bioquímica y Medicina Molecular. Facultad de Medicina. Centro de Investigación y Desarrollo en Ciencias de la Salud. Universidad Autónoma de Nuevo León.
authors: Celia Nohemí
authors: CN
authors: Sánchez-Domínguez
authors: Miguel Angel
authors: MA
authors: Reyes-López
authors: Adriana
authors: A
authors: Bustamante
authors: Víctor
authors: V
authors: Treviño
authors: Herminia Guadalupe
authors: HG
authors: Martínez-Rodríguez
authors: Augusto
authors: A
authors: Rojas-Martínez
authors: Hugo Alberto
authors: HA
authors: Barrera-Saldaña
authors: Rocío
authors: R
authors: Ortiz-López
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000235:genetics / Q000401:mortality*; D005838:Genotype; D006801:Humans; D007182:Income; D007223:Infant; D007231:Infant, Newborn; D053208:Kaplan-Meier Estimate; D008800:Mexico / Q000453:epidemiology; D011660:Pulmonary Heart Disease / Q000401:mortality; D012307:Risk Factors; D055815:Young Adult