title: [Benefits of Decumanum Phlebodium intake on the muscle damage in the response to intense physical exercise in sedentary subjects].
abstract: BACKGROUND
  Intense physical exercise provoke muscle damage, that in sedentary people can increase cardiovascular risk. Phlebodium decumanum (PD) has shown to have immunomodulator effects in models of moderate intense physical activities in well conditioned groups. To evaluate the PD effects during eccentric exercise, as a model of muscle inflammation protocol, on a sedentary population with cardiovascular risk.
  
  
  METHODS
  This is an experimental, double-blind, multigroup randomized study. Experimental Group 1 (n = 17)received PD, 9 doses of 400 mg (total amount 3.6 g) every 8 hours during 3 days, and Control Group 2 (n = 16)received a placebo. All the subjects performed two treadmill ergoespirometry tests: first, a modified Bruce protocol to discard ischemic responses during exercise and to evaluate VO2max before the experimental phase;and second, with an eccentric protocol (14% descending ramp test) during 10 minutes in stable state at 70-80%VO2max, as experimental inflammatory protocol.We compared intra and inter groups to evaluate differences in the pre and post-test differences results on blood muscle damage variables.
  
  
  RESULTS
  The study shown statistically significant differences in all pre-post intra-groups results in muscle damage variables (CK, LDH and Myoglobin, but not in Cardiac Troponin), and in functional lower-limb test (SJand CMJ). The comparison of inter-group results shown less muscle damage and less functional lower-limb deterioration in Group 1 compared with Control group, with statistical significance in both cases. Differences in handgrip dynamometry were no statistically significant.
  
  
  CONCLUSIONS
  The eccentric exercise protocol in that study has proven to be a good model to induce muscle and functional damage in sedentary people. Short PD treatment has shown to reduce muscle and functional acute damages compared with placebo control group in this specific population.
authors: Catedrática. Facultad de Ciencias de la Salud. Departamento de Enfermería. Universidad de Granada. España.. carmenvarco@hotmail.com.
authors: M C
authors: MC
authors: Vargas Corzo
authors: Especialista en Medicina de la Educación Física y el Deporte. Centro Andaluz de Medicina del Deporte de Granada. España.. mariajaguilar@telefonica.net.
authors: M J
authors: MJ
authors: Aguilar Cordero
authors: Catedrático. Departamento de Enfermería. Facultad de Ciencias de la Salud. Universidad de Granada. España.. cdeteresa2403@gmail.com.
authors: C
authors: C
authors: de Teresa Galván
authors: Diplomado Universitario en Enfermería. Centro Andaluz de Medicina del Deporte de Granada. España.. tedipost.2012@gmail.com.
authors: D
authors: D
authors: Segura Millán
authors: Profesora Titular de Universidad. Departamento de Estadística e Investigación Operativa. Universidad de Granada. España.. tmiranda@ugr.es.
authors: M T
authors: MT
authors: Miranda Leon
authors: Diplomada Universitaria en Enfermería. Servicio Andaluz de Salud. Jaén. España.. gertru2001@hotmail.es.
authors: G
authors: G
authors: Castillo Rueda
authors: Especialista en Medicina de la Educación Física y el Deporte. Centro Andaluz Medicina del Deporte de Granada. Hospital Universitario San Juan de Dios. España.. rguisado@ugr.es.
authors: R
authors: R
authors: Guisado Barrilao
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D015444:Exercise; D005080:Exercise Test; D018737:Hand Strength; D006801:Humans; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength / Q000502:physiology; D018482:Muscle, Skeletal / Q000293:injuries*; D010936:Plant Extracts / Q000627:therapeutic use*; D029621:Polypodiaceae / Q000737:chemistry*; D057185:Sedentary Behavior
chemical_list: D010936:Plant Extracts