title: Comparing the effect of An's Shaobei Injection ([symbols; see text]) with Xiaozhiling Injection ([symbols; see text]) in patients with internal hemorrhoids of grade I-III: a prospective cohort study.
abstract: OBJECTIVE
  To compare the effect of An's Shaobei Injection ([symbols; see text]) with Xiaozhiling Injection ([symbols; see text]) in patients with internal hemorrhoids of grade I-III.
  
  
  METHODS
  This cohort study included 1,520 internal hemorrhoids patients with grade I-III who were scheduled for liquid injection treatment from July 2003 to July 2009. The cohort included patients who underwent either An's Shaobei Injection treatment (the treatment group, 760 cases) or Xiaozhiling Injection treatment (the control group, 760 cases). All patients were followed up regularly for 3 years; the observing indices included anal function recovery and clinical response after operation.
  
  
  RESULTS
  Among the 1,520 patients, 1,508 (99.2%) completed the 3-year follow-up. The efficacy rate was 97.5% in the treatment group, significantly higher than the control group (91.8%, P<0.01). The recurrence rate in the treatment group was 0.5%, significantly lower than that of the control group (1.3%, P<0.01). In addition, perianal callosity occurred in 8 cases (1.1%) and anorectal stricture in 26 cases (3.5%) after operation in the control group. There was no perianal callosity and anorectal stricture in the treatment group.
  
  
  CONCLUSIONS
  The treatment with An's Shaobei Injection demonstrated superior clinical effect to Xiaozhiling Injection with fewer adverse effects.
authors: Anorectal Department, China-Japan Friendship Hospital, Beijing, 100029, China, aay1010@163.com.
authors: A-yue
authors: AY
authors: An
authors: Da-yong
authors: DY
authors: Feng
authors: Chun-hui
authors: CH
authors: Wang
authors: Yu-ying
authors: YY
authors: Shi
authors: Jing-jing
authors: JJ
authors: Xiang
authors: Zhi-yong
authors: ZY
authors: Bai
authors: Kun-cheng
authors: KC
authors: Li
authors: Jin-yang
authors: JY
authors: Liu
mesh_terms: D000328:Adult; D001003:Anal Canal / Q000187:drug effects / Q000473:pathology; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D006484:Hemorrhoids / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000187:drug effects / Q000473:pathology; D011446:Prospective Studies; D012008:Recurrence; D012597:Sclerosing Solutions / Q000008:administration & dosage* / Q000009:adverse effects; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D004365:Drugs, Chinese Herbal; D012597:Sclerosing Solutions