title: Higher level of heme oxygenase-1 in patients with stroke than TIA.
abstract: BACKGROUND
  There is a reverse relationship between serum bilirubin level and incidence of stroke, heme oxygenase-1 (HO-1) can catalyze heme into bilirubin, it is unknown the association of HO-1 level with risk of stroke.
  
  
  METHODS
  Sixty patients with stroke and fifty patients with transient ischemic attack (TIA) were recruited. Serum level of HO-1, total and direct bilirubin, alanine transaminase, live function, lipid profile and infection status of patients were measured.
  
  
  RESULTS
  Significant differences were found between two groups in terms of serum levels of HO-1 (163.6±58.7 vs. 141.2±49.7, P=0.032), total bilirubin (10.1±4.6 vs. 15.8±2.7, P<0.001), direct bilirubin (3.2±2.1 vs. 5.9±1.2, P<0.001), fasting glucose (6.7±3.1 vs. 4.9±1.3, P<0.001), cholesterol (4.4±1.1 vs. 3.9±0.8, P=0.005) and diastolic blood pressure (DBP) (84.9±9.4 vs. 81.3±9.2, P=0.046). In multivariate analysis, serum direct bilirubin (OR, 2.83; P<0.001), total bilirubin (OR, 1.82, P=0.001), DBP (OR, 0.88, P=0.041), and fasting glucose (OR, 0.34, P<0.001) were independent predictors of stroke.
  
  
  CONCLUSIONS
  Serum HO-1 level is higher in patients with stroke than TIA, but the bilirubin level is lower in patients with stroke than TIA and is an independent predictor of stroke. Further studies are warranted to clarify the underlying link among HO-1, bilirubin and stroke.
authors: 1 Department of Neurology, 2 Department of Neurosurgery, 3 Department of Ophthalmology, First Affiliated Hospital of Jiamusi University, Jiamusi 154000, China ; 4 Department of Invasive Technology, Ditan Hospital, Capital Medical University, Beijing 100015, China ; 5 Clincical Laboratory, 6 Cardiovascular Surgery, China Japan-Friendship Hospital, Beijing 100029, China.
authors: Xin
authors: X
authors: Li
authors: 1 Department of Neurology, 2 Department of Neurosurgery, 3 Department of Ophthalmology, First Affiliated Hospital of Jiamusi University, Jiamusi 154000, China ; 4 Department of Invasive Technology, Ditan Hospital, Capital Medical University, Beijing 100015, China ; 5 Clincical Laboratory, 6 Cardiovascular Surgery, China Japan-Friendship Hospital, Beijing 100029, China.
authors: Guangfu
authors: G
authors: Song
authors: 1 Department of Neurology, 2 Department of Neurosurgery, 3 Department of Ophthalmology, First Affiliated Hospital of Jiamusi University, Jiamusi 154000, China ; 4 Department of Invasive Technology, Ditan Hospital, Capital Medical University, Beijing 100015, China ; 5 Clincical Laboratory, 6 Cardiovascular Surgery, China Japan-Friendship Hospital, Beijing 100029, China.
authors: Yuling
authors: Y
authors: Jin
authors: 1 Department of Neurology, 2 Department of Neurosurgery, 3 Department of Ophthalmology, First Affiliated Hospital of Jiamusi University, Jiamusi 154000, China ; 4 Department of Invasive Technology, Ditan Hospital, Capital Medical University, Beijing 100015, China ; 5 Clincical Laboratory, 6 Cardiovascular Surgery, China Japan-Friendship Hospital, Beijing 100029, China.
authors: Hongwei
authors: H
authors: Liu
authors: 1 Department of Neurology, 2 Department of Neurosurgery, 3 Department of Ophthalmology, First Affiliated Hospital of Jiamusi University, Jiamusi 154000, China ; 4 Department of Invasive Technology, Ditan Hospital, Capital Medical University, Beijing 100015, China ; 5 Clincical Laboratory, 6 Cardiovascular Surgery, China Japan-Friendship Hospital, Beijing 100029, China.
authors: Changqing
authors: C
authors: Li
authors: 1 Department of Neurology, 2 Department of Neurosurgery, 3 Department of Ophthalmology, First Affiliated Hospital of Jiamusi University, Jiamusi 154000, China ; 4 Department of Invasive Technology, Ditan Hospital, Capital Medical University, Beijing 100015, China ; 5 Clincical Laboratory, 6 Cardiovascular Surgery, China Japan-Friendship Hospital, Beijing 100029, China.
authors: Chengwu
authors: C
authors: Han
authors: 1 Department of Neurology, 2 Department of Neurosurgery, 3 Department of Ophthalmology, First Affiliated Hospital of Jiamusi University, Jiamusi 154000, China ; 4 Department of Invasive Technology, Ditan Hospital, Capital Medical University, Beijing 100015, China ; 5 Clincical Laboratory, 6 Cardiovascular Surgery, China Japan-Friendship Hospital, Beijing 100029, China.
authors: Shiyan
authors: S
authors: Ren
keywords: Heme oxygenase-1 (HO-1); bilirubin; stroke