title: Cytotoxic and anti-inflammatory prenylated benzoylphloroglucinols and xanthones from the twigs of Garcinia esculenta.
abstract: Five new prenylated benzoylphloroglucinol derivatives, garciesculentones A-E (1-5), a new xanthone, garciesculenxanthone A (6), and 15 known compounds were isolated from the petroleum ether extract and the EtOAc-soluble fraction of a 80% (v/v) EtOH extract of Garcinia esculenta. The structures of the new compounds were elucidated by 1D- and 2D-NMR spectroscopic analysis and mass spectrometry. Experimental and calculated ECD and a convenient modified Mosher's method were used to determine the absolute configurations. The cytotoxicity of these compounds were evaluated by MTT assay against three human cancer cell lines (HepG2, MCF-7, and MDA-MB-231) and against normal hepatic cells (HL-7702). In addition, these isolates were evaluated for their inhibitory effects on interferon-γ plus lipopolysaccharide-induced nitric oxide production in RAW264.7 cells.
authors: School of Pharmacy, Shanghai University of Traditional Chinese Medicine , Cai Lun Lu 1200, Shanghai 201203, People's Republic of China.
authors: Hong
authors: H
authors: Zhang
authors: Dan-Dan
authors: DD
authors: Zhang
authors: Yuan-Zhi
authors: YZ
authors: Lao
authors: Wen-Wei
authors: WW
authors: Fu
authors: Shuang
authors: S
authors: Liang
authors: Qing-Hong
authors: QH
authors: Yuan
authors: Ling
authors: L
authors: Yang
authors: Hong-Xi
authors: HX
authors: Xu
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005260:Female; D029760:Garcinia / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D007371:Interferon-gamma / Q000187:drug effects; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D019906:Nuclear Magnetic Resonance, Biomolecular; D010696:Phloroglucinol / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D054876:Prenylation; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D008070:Lipopolysaccharides; D044004:Xanthones; D009569:Nitric Oxide; D007371:Interferon-gamma; D010696:Phloroglucinol