title: Oxidative status parameters in children with urinary tract infection.
abstract: BACKGROUND
  Urinary tract infection (UTI) is one of the most common bacterial infectious diseases in children. The aim of this study was to determine the total prooxidant and antioxidant capacity of children with UTI, as well as changes of oxidative status parameters according to acute inflammation persistence and acute kidney injury (AKI) development.
  
  
  METHODS
  The patients enrolled in the study comprised 50 Caucasian children (median age was 6 months) with UTI. Total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), inflammation marker C-reactive protein (CRP) and renal function parameters urea and creatinine were analyzed in patient's serums.
  
  
  RESULTS
  According to duration of inflammation during UTI, TAS values were significantly higher (0.99 vs. 0.58 mmol/L, P = 0.017) and OSI values were significantly lower (0.032 vs. 0.041 AU, P = 0.037) in the subjects with longer duration of inflammation than in the subjects with shorter duration of inflammation. We did not find significant difference in basal values of oxidative status parameters according to AKI development.
  
  
  CONCLUSIONS
  OSI values could detect the simultaneous change of TAS and TOS due to change in the oxidative-antioxidant balance during the recovery of children with UTI. TAS and OSI as markers of oxidative stress during UTI are sensitive to accompanying inflammatory condition. Further investigations are needed to evaluate whether TAS, TOS and OSI could be used to monitor disease severity in children with UTI.
authors: Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
authors: Stanislava
authors: S
authors: Petrovic
authors: Natasa
authors: N
authors: Bogavac-Stanojevic
authors: Jelena
authors: J
authors: Kotur-Stevuljevic
authors: Amira
authors: A
authors: Peco-Antic
authors: Ivana
authors: I
authors: Ivanisevic
authors: Jasmina
authors: J
authors: Ivanisevic
authors: Dusan
authors: D
authors: Paripovic
authors: Zorana
authors: Z
authors: Jelic-Ivanovic
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood* / Q000175:diagnosis / Q000209:etiology / Q000382:microbiology; D000975:Antioxidants / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D015169:Colony Count, Microbial; D003404:Creatinine / Q000097:blood; D004926:Escherichia coli; D004927:Escherichia coli Infections / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000382:microbiology; D005260:Female; D006801:Humans; D007223:Infant; D007249:Inflammation / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000382:microbiology; D008297:Male; D018384:Oxidative Stress; D011446:Prospective Studies; D014508:Urea / Q000097:blood; D014552:Urinary Tract Infections / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000382:microbiology
chemical_list: D000975:Antioxidants; D014508:Urea; D002097:C-Reactive Protein; D003404:Creatinine