title: Clinical genetics of Alzheimer's disease.
abstract: Alzheimer's disease (AD) is the most common progressive neurodegenerative disease and the most common form of dementia in the elderly. It is a complex disorder with environmental and genetic components. There are two major types of AD, early onset and the more common late onset. The genetics of early-onset AD are largely understood with mutations in three different genes leading to the disease. In contrast, while susceptibility loci and alleles associated with late-onset AD have been identified using genetic association studies, the genetics of late-onset Alzheimer's disease are not fully understood. Here we review the known genetics of early- and late-onset AD, the clinical features of EOAD according to genotypes, and the clinical implications of the genetics of AD.
authors: Department of Neurology, Fujian Medical University Union Hospital, Fuzhou 350001, China.
authors: Zhangyu
authors: Z
authors: Zou
authors: Department of Neurology, Fujian Medical University Union Hospital, Fuzhou 350001, China.
authors: Changyun
authors: C
authors: Liu
authors: Department of Neurology, Fujian Medical University Union Hospital, Fuzhou 350001, China.
authors: Chunhui
authors: C
authors: Che
authors: Department of Neurology, Fujian Medical University Union Hospital, Fuzhou 350001, China.
authors: Huapin
authors: H
authors: Huang
mesh_terms: D017668:Age of Onset; D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics* / Q000473:pathology; D016564:Amyloid beta-Protein Precursor / Q000235:genetics*; D003704:Dementia / Q000235:genetics* / Q000473:pathology; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D009154:Mutation; D053764:Presenilin-1 / Q000235:genetics; D053766:Presenilin-2 / Q000235:genetics
chemical_list: D016564:Amyloid beta-Protein Precursor; C508853:PSEN1 protein, human; C508861:PSEN2 protein, human; D053764:Presenilin-1; D053766:Presenilin-2