title: Predictors of work-related sensitisation, allergic rhinitis and asthma in early work life.
abstract: Although work-related asthma and allergies are a huge burden for society, investigation of occupational exposures in early work life using an unexposed reference group is rare. Thus, the present analyses aimed to assess the potential impact of occupational exposure and other risk factors on the prevalence of work-related sensitisation and incidence of allergic rhinitis/asthma using a population-based approach and taking into account an unexposed reference group. In SOLAR (Study on Occupational Allergy Risks) II, German participants of ISAAC (International Study of Asthma and Allergies in Childhood) phase II were followed from childhood (9-11 years) until early adulthood (19-24 years). Data on 1570 participants were available to fit predictive models. Occupational exposure was not statistically significantly associated with disease prevalence/incidence. Sensitisation in childhood, parental asthma, environmental tobacco smoke exposure during puberty, sex and study location were statistically significant predictors of outcome. Our results indicate that occupational exposure is of little relevance for work-related sensitisation prevalence and allergic rhinitis/asthma incidence in early work life, while other risk factors can be used to improve career guidance for adolescents. Further research on the role of a potential healthy hire effect and the impact of longer exposure duration is needed.
authors: Occupational and Environmental Epidemiology and Net Teaching Unit, Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Hospital of Munich (LMU), Munich, Germany jessica.kellberger@med.lmu.de.
authors: Jessica
authors: J
authors: Kellberger
authors: Occupational and Environmental Epidemiology and Net Teaching Unit, Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Hospital of Munich (LMU), Munich, Germany.
authors: Astrid S
authors: AS
authors: Peters-Weist
authors: Occupational and Environmental Epidemiology and Net Teaching Unit, Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Hospital of Munich (LMU), Munich, Germany.
authors: Sabine
authors: S
authors: Heinrich
authors: Occupational and Environmental Epidemiology and Net Teaching Unit, Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Hospital of Munich (LMU), Munich, Germany.
authors: Susanne
authors: S
authors: Pfeiffer
authors: Paediatric Dept, University Hospital Carl Gustav Carus Dresden, TU Dresden, Dresden, Germany.
authors: Christian
authors: C
authors: Vogelberg
authors: Paediatric Dept, University Hospital Carl Gustav Carus Dresden, TU Dresden, Dresden, Germany.
authors: Diana
authors: D
authors: Roller
authors: Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.
authors: Jon
authors: J
authors: Genuneit
authors: Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.
authors: Gudrun
authors: G
authors: Weinmayr
authors: Dr. v. Haunersches Kinderspital, University Hospital of Munich (LMU), Munich, Germany.
authors: Erika
authors: E
authors: von Mutius
authors: Dept of Statistics, LMU Munich, Munich, Germany.
authors: Christian
authors: C
authors: Heumann
authors: Occupational and Environmental Epidemiology and Net Teaching Unit, Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Hospital of Munich (LMU), Munich, Germany.
authors: Dennis
authors: D
authors: Nowak
authors: Occupational and Environmental Epidemiology and Net Teaching Unit, Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Hospital of Munich (LMU), Munich, Germany.
authors: Katja
authors: K
authors: Radon
mesh_terms: D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D002648:Child; D004781:Environmental Exposure; D005260:Female; D005500:Follow-Up Studies; D005858:Germany; D006801:Humans; D008297:Male; D009784:Occupational Diseases / Q000209:etiology; D016273:Occupational Exposure; D065631:Rhinitis, Allergic / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D012307:Risk Factors; D012907:Smoking; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D055815:Young Adult