title: Amino acid capture and utilization within the Mycobacterium tuberculosis phagosome.
abstract: Mycobacterium tuberculosis, the agent of TB, is a facultative intracellular bacterial pathogen that replicates inside host macrophages and other phagocytes within a membrane-bound vacuole or phagosome. How M. tuberculosis captures and exploits vital nutrients inside host cells is an intensive research area that might lead to novel therapeutics for tuberculosis. Recent reports provided evidence that M. tuberculosis relies on amino acid uptake and degradation pathways to thrive inside its host. This opens novel research venues for the development of innovative antimicrobials against TB.
authors: Centre National de la Recherche Scientifique (CNRS), UMR 5089, Institut de Pharmacologie et de Biologie Structurale (IPBS), 205 Route de Narbonne, 31077 Toulouse Cedex 04, France.
authors: Alexandre
authors: A
authors: Gouzy
authors: Yannick
authors: Y
authors: Poquet
authors: Olivier
authors: O
authors: Neyrolles
mesh_terms: D026905:Amino Acid Transport Systems / Q000378:metabolism*; D001216:Asparagine / Q000378:metabolism*; D001224:Aspartic Acid / Q000378:metabolism*; D054884:Host-Pathogen Interactions; D008247:Lysosomes / Q000382:microbiology / Q000473:pathology; D008264:Macrophages / Q000276:immunology / Q000382:microbiology*; D009169:Mycobacterium tuberculosis / Q000276:immunology / Q000378:metabolism*; D010587:Phagocytosis / Q000276:immunology; D010588:Phagosomes / Q000378:metabolism; D014376:Tuberculosis / Q000382:microbiology
chemical_list: D026905:Amino Acid Transport Systems; D001224:Aspartic Acid; D001216:Asparagine
keywords: Mycobacterium tuberculosis; asparaginase; asparagine; aspartate; macrophage; permease; phagosome