title: Anaplastic pilocytic astrocytoma.
abstract: This clinical series examines the presentation of three adult patients who were found to have de novo anaplastic pilocytic astrocytoma. Initial imaging demonstrated an intracranial mass with histological analysis diagnostic of pilocytic astrocytoma with anaplastic features including necrosis, marked nuclear pleomorphism and a very high mitotic rate leading to the diagnosis of anaplastic pilocytic astrocytoma. We discuss the clinical pitfalls, treatment and implications when managing this condition.
authors: Department of Neurosurgery, St Vincent's Hospital Melbourne, P.O. Box 2900, Fitzroy, VIC 3065, Australia. Electronic address: eric.yong@svhm.org.au.
authors: Eric X Z
authors: EX
authors: Yong
authors: Department of Anatomical Pathology, St Vincent's Hospital Melbourne, VIC, Australia.
authors: Penny
authors: P
authors: McKelvie
authors: Department of Neurosurgery, St Vincent's Hospital Melbourne, P.O. Box 2900, Fitzroy, VIC 3065, Australia; Department of Surgery, The University of Melbourne, VIC, Australia.
authors: Michael
authors: M
authors: Murphy
authors: Department of Neurosurgery, St Vincent's Hospital Melbourne, P.O. Box 2900, Fitzroy, VIC 3065, Australia; Department of Surgery, The University of Melbourne, VIC, Australia.
authors: Yi Yuen
authors: YY
authors: Wang
mesh_terms: D000328:Adult; D001254:Astrocytoma / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008940:Mitotic Index; D009336:Necrosis; D060787:Neoplasm Grading; D017253:Neurofibromatoses / Q000209:etiology; D010211:Papilledema / Q000209:etiology
keywords: Adult brain tumour; Anaplastic pilocytic astrocytoma; Malignant pilocytic astrocytoma; Neurofibromatosis; Pilocytic astrocytoma