title: Elevated urinary levels of cystatin C and neutrophil gelatinase-associated lipocalin in Henoch-Schönlein purpura patients with renal involvement.
abstract: Henoch-Schönlein purpura (HSP) is a commonest systemic vasculitis in childhood. The long-term prognosis of HSP is determined by the degree of renal involvement. The aim of this study is to search novel clinically applicable biomarkers to evaluate renal involvement in HSP patients. 20 bio-indexes in urine samples were simultaneously screened by antibody array assay. We indicated that urinary levels of cystatin C (Cys C) and neutrophil gelatinase-associated lipocalin (NGAL) in HSP patients with renal involvement were significantly higher than those without renal involvement and healthy controls. Furthermore, ELISA was used to analyze urinary Cys C and NGAL levels in HSP patients with or without renal involvement, atopic dermatitis (AD) patients and healthy controls. Our results demonstrated that urinary Cys C and NGAL levels in HSP patients with renal involvement were significantly elevated, when compared with those without renal involvement, AD patients and control subjects. In addition, by receiver operating characteristic (ROC) curve analysis, we demonstrated that the area under the ROC curve of NGAL (0.789) was larger than that of Cys C (0.692). Taken together, we show firstly that urinary Cys C and NGAL levels is abnormally elevated in HSP patients with renal involvement. We suggest that urinary Cys C and NGAL are novel useful biomarkers of renal involvement in HSP patients.
authors: Department of Dermatovenereology, Chengdu second people's hospital, Chengdu, China.
authors: Tao
authors: T
authors: Chen
authors: Department of Dermatovenereology, Chengdu second people's hospital, Chengdu, China.
authors: Yong-hong
authors: YH
authors: Lu
authors: Department of Dermatovenereology, Chengdu second people's hospital, Chengdu, China.
authors: Wen-ju
authors: WJ
authors: Wang
authors: Department of Dermatovenereology, Chengdu second people's hospital, Chengdu, China.
authors: Cai-yun
authors: CY
authors: Bian
authors: Department of Nephrology, Chengdu second people's hospital, Chengdu, China; Department of Rheumatology, Chengdu second people's hospital, Chengdu, China.
authors: Xiao-yun
authors: XY
authors: Cheng
authors: Department of Nephrology, Chengdu second people's hospital, Chengdu, China.
authors: Yu
authors: Y
authors: Su
authors: Department of Dermatovenereology, Chengdu second people's hospital, Chengdu, China.
authors: Pei-mei
authors: PM
authors: Zhou
mesh_terms: D000209:Acute-Phase Proteins / Q000652:urine*; D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000652:urine*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D055316:Cystatin C / Q000652:urine*; D003876:Dermatitis, Atopic / Q000175:diagnosis* / Q000652:urine; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D011695:IgA Vasculitis / Q000175:diagnosis* / Q000652:urine; D007668:Kidney / Q000503:physiopathology*; D000071068:Lipocalin-2; D054834:Lipocalins / Q000652:urine*; D008297:Male; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000652:urine*; D012372:ROC Curve; D055815:Young Adult
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; D055316:Cystatin C; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins