title: Severe androgenetic alopecia as a proxy of metabolic syndrome in male psoriatic patients older than 59 years.
abstract: BACKGROUND
  Whereas several studies have underlined the association between severe psoriasis and metabolic syndrome (MetS), the association of androgenetic alopecia (AGA) and MetS have yielded inconsistent results.
  
  
  OBJECTIVE
  To investigate the relationship between AGA and the components of MetS in a population of psoriatic male patients.
  
  
  METHODS
  A non-interventional, cross-sectional, multicenter study was conducted in France. A standardized questionnaire was completed, including information on components of MetS and other possible risk factors. MetS was defined in this study as a combination of three or more of the four components of MetS: waist circumference, hyperlipidemia, diabetes mellitus and hypertension. In addition, a standardized simplified Norwood classification limited into 5 grades (0-4) was used.
  
  
  RESULTS
  In a total of 1073 male patients, hypertension, high waist circumference, diabetes mellitus and hyperlipidemia were observed in 28%, 59%, 11%, and 31%, respectively. In age-adjusted multivariate analysis, severe AGA (grade 3-4 versus grade 0) was associated with the presence of at least one component of MetS. By groups of age, a statistically significant association of severe AGA and MetS was demonstrated in patients over 59 years. Severe AGA was also associated with a first degree familial history of major cardiovascular event in patients older than 59 years.
  
  
  CONCLUSIONS
  Our study, based on a simplified but stringent definition of MetS, confirmed the link between severe AGA and individual components of MetS in psoriatic patients. This argues for careful follow-up with regular screening in male psoriatic patients with severe AGA in order to early detect determinants of MetS.
authors: Department of Dermatology, Bichat Claude Bernard Hospital, APHP Paris Diderot University 46 rue Henri Huchard, 75877 Paris Cedex 18, France.
authors: Vincent
authors: V
authors: Descamps
authors: Department of Dermatology, Hôpital Victor Dupouy, Argenteuil, France.
authors: Emmanuel
authors: E
authors: Mahé
authors: Department of Dermatology, Hôpital d'Instruction des Armées Bégin, Saint-Mandé, France.
authors: François
authors: F
authors: Maccari
authors: Department of Dermatology, CH de Pontoise, Pontoise, France.
authors: Edouard
authors: E
authors: Begon
authors: Department of Dermatology, CH d'Auxerre, Auxerre, France.
authors: Hugues
authors: H
authors: Barthelemy
authors: Department of Dermatology, CHU de Reims, Reims, France.
authors: Ziad
authors: Z
authors: Reguiai
authors: Department of Dermatology, CH du Mans, Le Mans, France.
authors: Nathalie
authors: N
authors: Bénéton
authors: Department of Dermatology, CH Régional d'Orléans, Orléans, France.
authors: Eric
authors: E
authors: Estève
authors: Department of Dermatology, Hôpital Sud, CHU d'Amiens, Amiens, France.
authors: Guillaume
authors: G
authors: Chaby
authors: Martigues, France.
authors: Mireille
authors: M
authors: Ruer-Mulard
authors: Vienne, France.
authors: Henry-Georges
authors: HG
authors: Steiner
authors: Department of Dermatology, CH Intercommunal Poissy/Saint-Germain-en-Laye, Saint-Germain-en-Laye, France.
authors: Domitille
authors: D
authors: Thomas-Beaulieu
authors: Department of Dermatology, Hospital of Angers, Angers, France.
authors: Martine
authors: M
authors: Avenel-Audran
authors: Department of Clinical Immunology and Allergy, CHU Lyon-Sud, Lyon, France.
authors: Catherine
authors: C
authors: Goujon-Henry
authors: Department of Dermatology, Hôpital Victor Dupouy, Argenteuil, France.
authors: Michele-Lea
authors: ML
authors: Sigal
authors: Department of Dermatology, CHU de Bordeaux, Bordeaux, France.
authors: Khaled
authors: K
authors: Ezzedine
authors: Department of Public Health, CHU Ambroise Paré, University of Versailles-Saint Quentin en Yvelines, APHP, Boulogne-Billancourt, France.
authors: Alain
authors: A
authors: Beauchet
mesh_terms: D000328:Adult; D000505:Alopecia / Q000150:complications*; D003430:Cross-Sectional Studies; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000175:diagnosis; D008875:Middle Aged; D011446:Prospective Studies; D011565:Psoriasis / Q000150:complications*; D012720:Severity of Illness Index
keywords: androgenetic alopecia; hypertension; metabolic syndrome; psoriasis