title: Facile fabrication of a near-infrared responsive nanocarrier for spatiotemporally controlled chemo-photothermal synergistic cancer therapy.
abstract: Remote-controlled nanocarriers for drug delivery are of great promise to provide timely, sensitive and spatiotemporally selective treatments for cancer therapy. Due to convenient and precise manipulation, deep penetration through tissues and excellent biocompatibility, near-infrared (NIR) irradiation is a preferred external stimulus for triggering the release of loaded drugs. In this work, for spatiotemporally controlled chemo-photothermal synergistic cancer therapy, a NIR responsive nanocarrier was fabricated using reduced graphene oxide nanosheets (rNGO) decorated with mesoporous silica shell and the subsequent functionalization of the thermoresponsive polymer brushes (pNIPAM-co-pAAm) at the outlet of the silica pore channels. rNGO, which combined with the mesoporous silica shell provide a high loading capacity for anticancer drugs (doxorubicin, DOX), was assigned to sense NIR irradiation for the manipulation of pNIPAM-co-pAAm valve to control the diffusion of loaded DOX. Under NIR irradiation, rNGO would generate heat, which could not only elevate the surrounding temperature over the low critical solution temperature (LCST) of pNIPAM-co-pAAm to open the thermoresponsive polymer valve and promote the diffusion of DOX, but also kill the cancer cells through the hypothermia effect. By manipulating NIR irradiation, the nanocarrier exhibited efficiently controlled release of loaded DOX both in the buffer and in living HeLa cells (the model cancer cells), providing powerful and site-targeted treatments, which can be attributed to synergistic effects of chemo-photothermal therapy. To sum up, this novel nanocarrier is an excellent drug delivery platform in remote-controlled chemo-photothermal synergistic cancer therapy via NIR irradiation.
authors: CAS Key Laboratory of Separation Sciences for Analytical Chemistry, National Chromatographic R&A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Dalian 116023, China. hanfazou@dicp.ac.cn.
authors: Hao
authors: H
authors: Wan
authors: Yi
authors: Y
authors: Zhang
authors: Zheyi
authors: Z
authors: Liu
authors: Guiju
authors: G
authors: Xu
authors: Guang
authors: G
authors: Huang
authors: Yongsheng
authors: Y
authors: Ji
authors: Zhichao
authors: Z
authors: Xiong
authors: Quanqing
authors: Q
authors: Zhang
authors: Jing
authors: J
authors: Dong
authors: Weibing
authors: W
authors: Zhang
authors: Hanfa
authors: H
authors: Zou
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry; D004058:Diffusion; D004317:Doxorubicin / Q000008:administration & dosage; D016503:Drug Delivery Systems; D006108:Graphite / Q000737:chemistry; D006367:HeLa Cells; D006358:Hot Temperature; D006801:Humans; D007834:Lasers; D018613:Microscopy, Confocal; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology; D009369:Neoplasms / Q000628:therapy*; D010087:Oxides / Q000737:chemistry; D010777:Photochemistry; D011108:Polymers / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry; D019265:Spectroscopy, Near-Infrared
chemical_list: D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D010087:Oxides; D011108:Polymers; D012822:Silicon Dioxide; D006108:Graphite; D004317:Doxorubicin