title: Fabrication of corona-free nanoparticles with tunable hydrophobicity.
abstract: A protein corona is formed at the surface of nanoparticles in the presence of biological fluids, masking the surface properties of the particle and complicating the relationship between chemical functionality and biological effects. We present here a series of zwitterionic NPs of variable hydrophobicity that do not adsorb proteins at moderate levels of serum protein and do not form hard coronas at physiological serum concentrations. These particles provide platforms to evaluate nanobiological behavior such as cell uptake and hemolysis dictated directly by chemical motifs at the nanoparticle surface.
authors: Department of Chemistry, University of Massachusetts Amherst , 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.
authors: Daniel F
authors: DF
authors: Moyano
authors: Krishnendu
authors: K
authors: Saha
authors: Gyan
authors: G
authors: Prakash
authors: Bo
authors: B
authors: Yan
authors: Hao
authors: H
authors: Kong
authors: Mahdieh
authors: M
authors: Yazdani
authors: Vincent M
authors: VM
authors: Rotello
mesh_terms: D000327:Adsorption; D001692:Biological Transport; D001798:Blood Proteins / Q000737:chemistry; D006461:Hemolysis / Q000187:drug effects; D057927:Hydrophobic and Hydrophilic Interactions; D061986:MCF-7 Cells; D053758:Nanoparticles / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D036103:Nanotechnology / Q000379:methods*; D013499:Surface Properties
chemical_list: D001798:Blood Proteins