title: Peptides regulate expression of signaling molecules in kidney cell cultures during in vitro aging.
abstract: We studied the effect of polypeptide complex isolated from calf kidney and short peptides T-31 (AED) and T-35 (EDL) on the expression of signaling molecules, markers of cell renewal (Ki-67, p53), remodeling of the extracellular matrix (MMP-14), and immune response (IL-8) in primary kidney cell cultures during aging. The complex of renal polypeptides and T-31 peptide activate cell renewal processes during aging of the renal epithelium, while gelatinase MMP-14 is the target of T-35 peptide.
authors: I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
authors: V Kh
authors: VKh
authors: Khavinson
authors: N S
authors: NS
authors: Lin'kova
authors: V O
authors: VO
authors: Polyakova
authors: A O
authors: AO
authors: Durnova
authors: T E
authors: TE
authors: Nichik
authors: I M
authors: IM
authors: Kvetnoi
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D016922:Cellular Senescence / Q000187:drug effects*; D016209:Interleukin-8 / Q000378:metabolism; D019394:Ki-67 Antigen / Q000378:metabolism; D007668:Kidney; D053511:Matrix Metalloproteinase 14 / Q000378:metabolism; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D016209:Interleukin-8; D019394:Ki-67 Antigen; D010455:Peptides; D016159:Tumor Suppressor Protein p53; D053511:Matrix Metalloproteinase 14