title: Individual susceptibility to hypoperfusion and reductions in exercise performance when perfusion pressure is reduced: evidence for vasodilator phenotypes.
abstract: The primary objective of this study was to determine whether cardiovascular compensatory response phenotypes exist in the face of a reduced perfusion pressure challenge to exercising muscle oxygen delivery (O2D), and whether these responses might be exercise intensity (EI) dependent. Ten healthy men (19.5 ± 0.4 yr) completed two trials of progressive forearm isometric handgrip exercise to exhaustion (24.5 N increments every 3.5 min) in each of forearm above and below heart level [forearm arterial perfusion pressure (FAPP) difference of 29.5 ± 0.97 mmHg]. At the end of each EI, measurements of forearm blood flow (FBF; ml/min) via brachial artery Doppler and echo ultrasound, mean arterial blood pressure (MAP; mmHg) via finger photoplethysmography, and exercising forearm venous effluent via antecubital vein catheter revealed distinct cardiovascular response groups: n = 6 with compensatory vasodilation vs. n = 4 without compensatory vasodilation. Compensatory vasodilators were able to blunt the perfusion pressure-evoked reduction in submaximal O2D in the arm-above-heart condition, whereas nonvasodilators did not (-22.5 ± 13.6 vs. -65.4 ± 14.1 ml O2/min; P < 0.05), and in combination with being able to increase O2 extraction, nonvasodilators defended submaximal V̇o2 and experienced less of an accumulated submaximal O2D deficit (-80.7 ± 24.7 vs. -219.1 ± 36.0 ml O2/min; P < 0.05). As a result, the compensatory vasodilators experienced less of a compromise to peak EI than nonvasodilators (-24.5 ± 3.5 N vs. -52.1 ± 8.9 N; P < 0.05). In conclusion, in the forearm exercise model studied, vasodilatory response phenotypes exist that determine individual susceptibility to hypoperfusion and the degree to which aerobic metabolism and exercise performance are compromised.
authors: School of Kinesiology and Health Studies, Queen's University, Kingston, Ontario, Canada.
authors: Robert F
authors: RF
authors: Bentley
authors: School of Kinesiology and Health Studies, Queen's University, Kingston, Ontario, Canada.
authors: J Mikhail
authors: JM
authors: Kellawan
authors: School of Kinesiology and Health Studies, Queen's University, Kingston, Ontario, Canada.
authors: Jackie S
authors: JS
authors: Moynes
authors: School of Kinesiology and Health Studies, Queen's University, Kingston, Ontario, Canada.
authors: Veronica J
authors: VJ
authors: Poitras
authors: School of Kinesiology and Health Studies, Queen's University, Kingston, Ontario, Canada.
authors: Jeremy J
authors: JJ
authors: Walsh
authors: School of Kinesiology and Health Studies, Queen's University, Kingston, Ontario, Canada mt29@queensu.ca.
authors: Michael E
authors: ME
authors: Tschakovsky
mesh_terms: D000293:Adolescent; D015444:Exercise / Q000502:physiology*; D017079:Exercise Tolerance / Q000502:physiology*; D005542:Forearm / Q000098:blood supply; D018737:Hand Strength / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D009043:Motor Activity; D018482:Muscle, Skeletal / Q000098:blood supply / Q000502:physiology; D010101:Oxygen Consumption / Q000502:physiology; D010641:Phenotype; D012039:Regional Blood Flow / Q000502:physiology; D014664:Vasodilation / Q000502:physiology*; D055815:Young Adult
chemical_list: D006454:Hemoglobins
keywords: exercise; oxygen delivery; perfusion pressure