title: Singlet molecular oxygen generated by biological hydroperoxides.
abstract: The chemistry behind the phenomenon of ultra-weak photon emission has been subject of considerable interest for decades. Great progress has been made on the understanding of the chemical generation of electronically excited states that are involved in these processes. Proposed mechanisms implicated the production of excited carbonyl species and singlet molecular oxygen in the mechanism of generation of chemiluminescence in biological system. In particular, attention has been focused on the potential generation of singlet molecular oxygen in the recombination reaction of peroxyl radicals by the Russell mechanism. In the last ten years, our group has demonstrated the generation of singlet molecular oxygen from reactions involving the decomposition of biologically relevant hydroperoxides, especially from lipid hydroperoxides in the presence of metal ions, peroxynitrite, HOCl and cytochrome c. In this review we will discuss details on the chemical aspects related to the mechanism of singlet molecular oxygen generation from different biological hydroperoxides.
authors: Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, CP26077, CEP 05513-970 São Paulo, SP, Brazil. Electronic address: miyamoto@iq.usp.br.
authors: Sayuri
authors: S
authors: Miyamoto
authors: Departamento de Bioquímica e Biologia Molecular, Setor de Ciências Biológicas, Universidade Federal do Paraná, Curitiba-PR, Brazil.
authors: Glaucia R
authors: GR
authors: Martinez
authors: Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, CP26077, CEP 05513-970 São Paulo, SP, Brazil.
authors: Marisa H G
authors: MH
authors: Medeiros
authors: Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, CP26077, CEP 05513-970 São Paulo, SP, Brazil. Electronic address: pdmascio@iq.usp.br.
authors: Paolo
authors: P
authors: Di Mascio
mesh_terms: D000818:Animals; D006801:Humans; D006861:Hydrogen Peroxide / Q000737:chemistry* / Q000378:metabolism*; D008027:Light; D051336:Mitochondrial Membranes / Q000378:metabolism; D018462:Photobiology / Q000379:methods*; D026082:Singlet Oxygen / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D026082:Singlet Oxygen; D006861:Hydrogen Peroxide
keywords: Lipid hydroperoxides; Peroxyl radicals; Singlet molecular oxygen; Ultra-weak photon emission