title: CXCL17 is a major chemotactic factor for lung macrophages.
abstract: Chemokines are a superfamily of chemotactic cytokines that direct the movement of cells throughout the body under homeostatic and inflammatory conditions. The mucosal chemokine CXCL17 was the last ligand of this superfamily to be characterized. Several recent studies have provided greater insight into the basic biology of this chemokine and have implicated CXCL17 in several human diseases. We sought to better characterize CXCL17's activity in vivo. To this end, we analyzed its chemoattractant properties in vivo and characterized a Cxcl17 (-/-) mouse. This mouse has a significantly reduced number of macrophages in its lungs compared with wild-type mice. In addition, we observed a concurrent increase in a new population of macrophage-like cells that are F4/80(+)CDllc(mid). These results indicate that CXCL17 is a novel macrophage chemoattractant that operates in mucosal tissues. Given the importance of macrophages in inflammation, these observations strongly suggest that CXCL17 is a major regulator of mucosal inflammatory responses.
authors: Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, Irvine, CA 92697; Institute for Immunology, University of California, Irvine, Irvine, CA 92697; and.
authors: Amanda M
authors: AM
authors: Burkhardt
authors: Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, Irvine, CA 92697; Institute for Immunology, University of California, Irvine, Irvine, CA 92697; and.
authors: José L
authors: JL
authors: Maravillas-Montero
authors: Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, Irvine, CA 92697; Institute for Immunology, University of California, Irvine, Irvine, CA 92697; and.
authors: Christina D
authors: CD
authors: Carnevale
authors: Department of Pathologic Anatomy and Cytopathology, University of Nuevo Leon, Monterrey, Nuevo Leon 64460, Mexico.
authors: Natalia
authors: N
authors: Vilches-Cisneros
authors: Department of Pathologic Anatomy and Cytopathology, University of Nuevo Leon, Monterrey, Nuevo Leon 64460, Mexico.
authors: Juan P
authors: JP
authors: Flores
authors: Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, Irvine, CA 92697; Institute for Immunology, University of California, Irvine, Irvine, CA 92697; and.
authors: Peter A
authors: PA
authors: Hevezi
authors: Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, Irvine, CA 92697; Institute for Immunology, University of California, Irvine, Irvine, CA 92697; and azlotnik@uci.edu.
authors: Albert
authors: A
authors: Zlotnik
mesh_terms: D000818:Animals; D019743:Chemokines, CXC / Q000502:physiology*; D006706:Homeostasis / Q000276:immunology; D016130:Immunophenotyping; D007249:Inflammation / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D018836:Inflammation Mediators / Q000502:physiology; D008168:Lung / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D016676:Macrophages, Alveolar / Q000166:cytology / Q000276:immunology* / Q000473:pathology; D051379:Mice; D018345:Mice, Knockout; D020545:Respiratory Mucosa / Q000276:immunology / Q000378:metabolism / Q000473:pathology
chemical_list: C000591605:CXCL17 protein, mouse; D019743:Chemokines, CXC; D018836:Inflammation Mediators