title: Effect of rs6923761 gene variant of glucagon-like peptide 1 receptor on metabolic response and weight loss after a 3-month intervention with a hypocaloric diet.
abstract: BACKGROUND
  Studies of the GLP-1 receptor (GLP-1 R) have been directed at identifying polymorphisms in the GLP-1 R gene that may be a contributing factor in the pathogenesis of obesity and cardiovascular risk factors. Nevertheless, the role of GLP-1 R variants on body weight response after dietary intervention has not been evaluated.
  
  
  OBJECTIVE
  We decided to analyze the effects of the rs6923761 GLP-1 R polymorphism on body weight changes and metabolic parameters after 3 months of a hypocaloric diet.
  
  
  METHODS
  A sample of 91 obese subjects was analyzed in a prospective way. The hypocaloric diet had 1,520 calories per day; 52 % of carbohydrates, 25 % of lipids and 23 % of proteins. Distribution of fats was: 50.7 % of monounsaturated fats, 38.5 % of saturated fats and 11.8 % of polyunsaturated fats.
  
  
  RESULTS
  In both genotype groups (GG vs. GA + AA), weight, body mass index, fat mass, waist circumference, systolic blood pressure, total cholesterol, LDL cholesterol, leptin, insulin and HOMA levels decreased. No statistical differences were detected in these changes between genotypes. In wild group (GG genotype) (pretreatment and posttreatment), BMI, weight, fat mass, waist circumference and triglyceride levels were higher than (GA + AA) group.
  
  
  CONCLUSIONS
  Our data showed better anthropometric parameters and triglyceride levels in obese subjects with the mutant allele (A) of rs6923761 GLP-1R polymorphism. A lack of association of this polymorphism with weight loss or biochemical changes after a hypocaloric diet was observed.
authors: Center of Investigation of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, C/Los perales 16, 47130, Simancas, Valladolid, Spain, dadluis@yahoo.es.
authors: Daniel Antonio
authors: DA
authors: de Luis
authors: Rocío
authors: R
authors: Aller
authors: Olatz
authors: O
authors: Izaola
authors: J J
authors: JJ
authors: Lopez
authors: E
authors: E
authors: Gomez
authors: B
authors: B
authors: Torres
authors: G Diaz
authors: GD
authors: Soto
mesh_terms: D000328:Adult; D031204:Caloric Restriction / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D000067757:Glucagon-Like Peptide-1 Receptor / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics / Q000378:metabolism / Q000628:therapy; D011110:Polymorphism, Genetic; D016896:Treatment Outcome; D015431:Weight Loss / Q000235:genetics* / Q000502:physiology
chemical_list: D000067757:Glucagon-Like Peptide-1 Receptor