title: Narrow-band imaging system with magnifying endoscopy for early oral cancer.
abstract: It is often difficult to detect early oral cancer due to the specificity of the oral mucosa structure. The aim of this study was to investigate the potential of narrow band imaging (NBI) as an effective and non-invasive diagnostic tool in early oral cancer and other oral diseases. A magnifying endoscopy system manufactured by Olympus Corporation was used. A total of 121 subjects were included in the study. Subepithelial capillary loops were identified and categorized according to the classification of Inoue, with healthy mucosa graded as Type I or II, and that showing evidence of cancer-induced morphological change as Type III or IV. Sensitivity and specificity for the identification of oral cancer were estimated at 92.3% and 88.2%, respectively. Examination under a microscope with H&E staining and immunostaining for CD34 revealed dilation and extension of the capillaries in epithelial dysplasia, in addition to thickening of the epithelial layer. The present results indicate that use of NBI in conjunction with conventional magnifying endoscopy has great potential as an effective and non-invasive diagnostic tool in the early detection of oral cancer.
authors: Department of Oral and Maxillofacial Surgery, Tokyo Dental College.
authors: Takahiko
authors: T
authors: Shibahara
authors: Nobuharu
authors: N
authors: Yamamoto
authors: Takashi
authors: T
authors: Yakushiji
authors: Takeshi
authors: T
authors: Nomura
authors: Riyo
authors: R
authors: Sekine
authors: Kyotaro
authors: K
authors: Muramatsu
authors: Hitoshi
authors: H
authors: Ohata
mesh_terms: D018952:Antigens, CD34 / Q000032:analysis; D002196:Capillaries / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000098:blood supply / Q000175:diagnosis; D004108:Dilatation, Pathologic / Q000473:pathology; D055088:Early Detection of Cancer / Q000379:methods* / Q000706:statistics & numerical data; D019723:Endoscopes; D004724:Endoscopy / Q000379:methods* / Q000706:statistics & numerical data; D004848:Epithelium / Q000098:blood supply / Q000473:pathology; D004867:Equipment Design; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007972:Leukoplakia, Oral / Q000098:blood supply / Q000175:diagnosis; D017676:Lichen Planus, Oral / Q000175:diagnosis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000098:blood supply; D009062:Mouth Neoplasms / Q000098:blood supply / Q000175:diagnosis*; D062048:Narrow Band Imaging / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D011230:Precancerous Conditions / Q000098:blood supply / Q000175:diagnosis; D012680:Sensitivity and Specificity
chemical_list: D018952:Antigens, CD34