title: Primary breast lymphoma.
abstract: Primary breast lymphoma is a rare form of extranodal lymphoma, defined by the presence of a primary lesion within the breast with or without regional nodal involvement but no other extra-mammary sites of involvement. It comprises diverse histologic subtypes, but diffuse large B-cell lymphoma is the most common. In this review, we describe in detail the clinical features, diagnosis and staging, pathogenesis, risk factors and therapy of primary breast diffuse large B-cell lymphoma. We consider choice and number of cycles of chemotherapy, the indications for radiotherapy and discuss the need for central nervous system prophylaxis. We also provide a brief overview of the less commonly encountered histologic subtypes including marginal zone, follicular, Burkitt and breast implant associated anaplastic large cell lymphoma. We conclude with a suggested treatment approach and potential areas of future research.
authors: Department of Haematology, Peter MacCallum Cancer Centre, East Melbourne, Melbourne, Victoria, Australia; University of Melbourne, Parkville, Melbourne, Victoria, Australia. Electronic address: chan.cheah@petermac.org.
authors: Chan Y
authors: CY
authors: Cheah
authors: University of Melbourne, Parkville, Melbourne, Victoria, Australia; Division of Radiation Oncology, Peter MacCallum Cancer Centre, East Melbourne, Melbourne, Victoria, Australia. Electronic address: Belinda.campbell@petermac.org.
authors: Belinda A
authors: BA
authors: Campbell
authors: Department of Haematology, Peter MacCallum Cancer Centre, East Melbourne, Melbourne, Victoria, Australia; University of Melbourne, Parkville, Melbourne, Victoria, Australia. Electronic address: john.seymour@petermac.org.
authors: John F
authors: JF
authors: Seymour
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*
keywords: Breast neoplasms; Extranodal lymphoma; Non-Hodgkin lymphoma; Primary breast lymphoma; Review article