title: Total synthesis of gonytolides C and G, lachnone C, and formal synthesis of blennolide C and diversonol.
abstract: The first stereoselective total synthesis of gonytolide C, which is a monomeric unit of an innate immune promoter gonytolide A, has been accomplished from the aldol reaction between acetophenone derived from orcinol and butyrolactone containing α-keto ester followed by the excellent diastereoselective intramolecular cyclization. The first total synthesis of gonytolide G has been achieved by the oxidation of benzylic methyl in gonytolide C. Additionally, total synthesis of lachnone C and a formal synthesis of blennolide C and diversonol have been achieved by this synthetic method.
authors: Division of CPC (Organic Chemistry-II), CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad-500007, India. gsudhakar@iict.res.in.
authors: Gangarajula
authors: G
authors: Sudhakar
authors: Shruthi
authors: S
authors: Bayya
authors: Vilas D
authors: VD
authors: Kadam
authors: Jagadeesh Babu
authors: JB
authors: Nanubolu
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D002867:Chromones / Q000138:chemical synthesis* / Q000737:chemistry; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D066244:Proton Magnetic Resonance Spectroscopy; D013237:Stereoisomerism; D013696:Temperature; D013997:Time Factors; D044004:Xanthones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D002867:Chromones; D007783:Lactones; D044004:Xanthones; C531519:blennolide C; C514121:diversonol; C570503:lachnone C; D015107:4-Butyrolactone