title: Unveiling cell surface and type IV secretion proteins responsible for archaeal rudivirus entry.
abstract: Sulfolobus mutants resistant to archaeal lytic virus Sulfolobus islandicus rod-shaped virus 2 (SIRV2) were isolated, and mutations were identified in two gene clusters, cluster sso3138 to sso3141 and cluster sso2386 and sso2387, encoding cell surface and type IV secretion proteins, respectively. The involvement of the mutations in the resistance was confirmed by genetic complementation. Blocking of virus entry into the mutants was demonstrated by the lack of early gene transcription, strongly supporting the idea of a role of the proteins in SIRV2 entry.
authors: Archaea Centre, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
authors: Ling
authors: L
authors: Deng
authors: Archaea Centre, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
authors: Fei
authors: F
authors: He
authors: Archaea Centre, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
authors: Yuvaraj
authors: Y
authors: Bhoobalan-Chitty
authors: Archaea Centre, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
authors: Laura
authors: L
authors: Martinez-Alvarez
authors: Archaea Centre, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
authors: Yang
authors: Y
authors: Guo
authors: Archaea Centre, Department of Biology, University of Copenhagen, Copenhagen, Denmark Peng@bio.ku.dk.
authors: Xu
authors: X
authors: Peng
mesh_terms: D019843:Archaeal Proteins / Q000378:metabolism*; D005816:Genetic Complementation Test; D006790:Host-Parasite Interactions; D008565:Membrane Proteins / Q000378:metabolism*; D005810:Multigene Family; D009154:Mutation; D023642:Rudiviridae; D016944:Sulfolobus / Q000378:metabolism* / Q000821:virology*; D053586:Virus Internalization
chemical_list: D019843:Archaeal Proteins; D008565:Membrane Proteins