title: Autologous Fat Grafting for Treatment of Breast Implant Capsular Contracture: A Study in Pigs.
abstract: BACKGROUND
  Capsular contracture (CC) is a common complication after breast augmentation. Autologous fat grafting may be effective for restoring tissue vascularization and function.
  
  
  OBJECTIVE
  The authors evaluated the efficacy of autologous fat grafting in a porcine model as a treatment for CC after breast augmentation.
  
  
  METHODS
  This prospective study was performed in 20 female 30-day-old pigs. Each animal was implanted with three 30-cc textured silicone implants (stage 1 of the experiment). Group A served as the untreated control group. To induce CC, 2 mL of autologous fibrin glue was applied to the pericapsular space in group B and C animals at implantation. Three months after implantation (stage 2), the CCs of all groups were assessed by Baker classification and applanation tonometry (AT). Liposuction was performed in group B to harvest fat for these animals. Three months after group B underwent fat grafting, all 3 groups were reevaluated. Reassessments included Baker classification, AT, histologic analysis, and tensiometry (stage 3).
  
  
  RESULTS
  The deposition of mature and immature collagen was similar for the 3 groups. The amount of fat remaining around the implanted capsules did not differ significantly between the groups. At stage 3, group B exhibited significantly larger tonometry areas than did group C. The CCs in groups B and C were significantly thicker than those of group A, but the difference between groups B and C was not significant. Capsule rupture forces did not differ significantly between groups A and B but were significantly higher in group C compared with the other groups.
  
  
  CONCLUSIONS
  Results in this animal model indicate that pericapsular lipoinjection may be a promising treatment for CC in humans.
authors: Dr Roça is a plastic surgeon in private practice in Curitiba, Paraná, Brazil contato@guilhermeroca.com.br.
authors: Guilherme Berto
authors: GB
authors: Roça
authors: Dr Graf is Professor, Dr Freitas is Professor and Head of Unit, and Mr Maluf is a resident in the Plastic Surgery Unit, Federal University of Paraná, Brazil.
authors: Ruth
authors: R
authors: Graf
authors: Dr Graf is Professor, Dr Freitas is Professor and Head of Unit, and Mr Maluf is a resident in the Plastic Surgery Unit, Federal University of Paraná, Brazil.
authors: Renato
authors: R
authors: da Silva Freitas
authors: Drs Salles, Francisco, and Noronha are Professors at Pontifical Catholic University of Paraná, Brazil.
authors: Guataçara
authors: G
authors: Salles
authors: Drs Salles, Francisco, and Noronha are Professors at Pontifical Catholic University of Paraná, Brazil.
authors: Julio Cesar
authors: JC
authors: Francisco
authors: Drs Salles, Francisco, and Noronha are Professors at Pontifical Catholic University of Paraná, Brazil.
authors: Lucia
authors: L
authors: Noronha
authors: Dr Graf is Professor, Dr Freitas is Professor and Head of Unit, and Mr Maluf is a resident in the Plastic Surgery Unit, Federal University of Paraná, Brazil.
authors: Ivan
authors: I
authors: Maluf
mesh_terms: D000273:Adipose Tissue / Q000637:transplantation*; D000818:Animals; D019928:Breast Implantation / Q000009:adverse effects* / Q000295:instrumentation; D018427:Breast Implants; D004195:Disease Models, Animal; D005260:Female; D057910:Implant Capsular Contracture / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D012828:Silicones; D034421:Sus scrofa; D013997:Time Factors; D014182:Transplantation, Autologous
chemical_list: D012828:Silicones
keywords: applanation tonometry; autologous fat grafting; breast augmentation; capsular contracture; silicone breast implants