title: Correlates of sexual function in male and female patients with multiple sclerosis.
abstract: BACKGROUND
  Many factors have been suggested to contribute to sexual dysfunction (SD) in multiple sclerosis (MS) patients, but the research on their impact on sexual functioning (SF) and sexual quality of life (SQoL) remains scant.
  
  
  OBJECTIVE
  The aim of this study was to investigate correlates of SF and SQoL in MS patients, as well as possible gender differences.
  
  
  METHODS
  204 MS patients were interviewed, completed the questionnaires, and underwent neurological assessment.
  
  
  METHODS
  Primary outcome measures included the International Index of Erectile Function, the Female Sexual Function Questionnaire, the Sexual Quality of Life Questionnaire, the Beck Depression Inventory, and the Expanded Disability Status Scale.
  
  
  RESULTS
  The course and duration of the disease did not predict patients' SF. Negative correlations were found for brainstem symptoms with orgasmic function and overall satisfaction in men and between cognitive functioning and the partner domain in women. Interestingly, brainstem symptoms correlated positively with the arousal domain in women. More than half (52.1%) of patients fulfilled Beck Depression Inventory criteria for depression, and these patients showed more SD than nondepressive individuals. The strongest negative correlations with depressive symptoms were found for desire, erectile function, and overall satisfaction with sexual life in men and for orgasm and sexual enjoyment in women. Deterioration in particular domains of SF was clearly related with diminished SQoL. The main gender difference was a strong influence of decreased desire on SQoL in women and no such correlation in men. Negative assessment of the relationship with partner significantly affected all domains of SF and SQoL in MS women and the desire domain in MS men.
  
  
  CONCLUSIONS
  Several correlates of SF in MS patients were found. The role of brainstem symptoms needs further investigation. Clinicians should pay close attention to depressive symptoms and relationship factors in MS patients who suffer from SD.
authors: III Department of Psychiatry, Institute of Psychiatry and Neurology, Warsaw, Poland.
authors: Michal
authors: M
authors: Lew-Starowicz
authors: Rafal
authors: R
authors: Rola
mesh_terms: D000328:Adult; D003863:Depression / Q000209:etiology* / Q000503:physiopathology / Q000523:psychology; D006233:Persons with Disabilities; D005260:Female; D006801:Humans; D007989:Libido; D008297:Male; D009103:Multiple Sclerosis / Q000150:complications* / Q000503:physiopathology / Q000523:psychology; D009948:Orgasm; D010549:Personal Satisfaction; D011788:Quality of Life; D012725:Sexual Behavior; D012735:Sexual Dysfunction, Physiological / Q000209:etiology* / Q000503:physiopathology / Q000523:psychology; D011795:Surveys and Questionnaires
keywords: Correlates of Sexual Function; Gender Differences; Multiple Sclerosis; Neurologic Male and Female Sexual Dysfunction; Sexual Dysfunction; Sexual Quality of Life