title: A trehalose ester from Lancea tibetica.
abstract: A phytochemical study of the 95% ethanolic extract of the whole plant of Lancea tibetica Hook. f. et Thoms. led to the isolation of a new trehalose ester, 6-O-undecanoyl-α,β-trehalose (1), along with 23 known compounds (2-24), of which compounds 2-17 were isolated from this plant for the first time. The structures of these compounds were established on the basis of spectroscopic methods. Compound 1 was evaluated for their in vitro anti-proliferative activities against MCF-7, NCI-H460 and Hep-G2 tumour cell lines. Compound 1 exhibited potent inhibitory activity against NCI-H460 cell growth, in contrast to moderate cytotoxic activity against MCF-7 and Hep-G2 cells.
authors: a Department of Pharmaceutical Engineering , School of Chemistry and Chemical Engineering, Southeast University , Nanjing 211189 , P.R. China.
authors: Shi-Jun
authors: SJ
authors: Liu
authors: Zhi-Xin
authors: ZX
authors: Liao
authors: Chao
authors: C
authors: Liu
authors: Yan-Bo
authors: YB
authors: Qu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005260:Female; D056945:Hep G2 Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D014199:Trehalose / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C000594191:6-O-undecanoyl-alpha,beta-trehalose; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D014199:Trehalose
keywords: Lancea tibetica; anti-tumour activity; flavone; trehalose ester; triterpenoid