title: Controlled release from recombinant polymers.
abstract: Recombinant polymers provide a high degree of molecular definition for correlating structure with function in controlled release. The wide array of amino acids available as building blocks for these materials lend many advantages including biorecognition, biodegradability, potential biocompatibility, and control over mechanical properties among other attributes. Genetic engineering and DNA manipulation techniques enable the optimization of structure for precise control over spatial and temporal release. Unlike the majority of chemical synthetic strategies used, recombinant DNA technology has allowed for the production of monodisperse polymers with specifically defined sequences. Several classes of recombinant polymers have been used for controlled drug delivery. These include, but are not limited to, elastin-like, silk-like, and silk-elastinlike proteins, as well as emerging cationic polymers for gene delivery. In this article, progress and prospects of recombinant polymers used in controlled release will be reviewed.
authors: Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, USA; Utah Center for Nanomedicine, Nano Institute of Utah, University of Utah, Salt Lake City, UT, USA.
authors: Robert
authors: R
authors: Price
authors: Utah Center for Nanomedicine, Nano Institute of Utah, University of Utah, Salt Lake City, UT, USA; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA.
authors: Azadeh
authors: A
authors: Poursaid
authors: Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, USA; Utah Center for Nanomedicine, Nano Institute of Utah, University of Utah, Salt Lake City, UT, USA; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA. Electronic address: hamid.ghandehari@pharm.utah.edu.
authors: Hamidreza
authors: H
authors: Ghandehari
mesh_terms: D000818:Animals; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004549:Elastin / Q000737:chemistry; D006801:Humans; D010455:Peptides / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011994:Recombinant Proteins; D047011:Silk / Q000737:chemistry
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D010455:Peptides; D011108:Polymers; D011994:Recombinant Proteins; D047011:Silk; D004549:Elastin
keywords: Controlled release; Elastin-like Polypeptides (ELP); Recombinant Cationic Polymers (RCP); Recombinant polymers; Silk-elastinlike Protein Polymers (SELP); Silk-like Polypeptides (SLP)