title: Relapsing polymyositis in chronic graft versus host disease.
abstract: Chronic graft versus host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplantation, which contributes to the morbidity and mortality of transplant patients. A polymyositis pattern of injury is a rare manifestation of chronic GVHD in skeletal muscle after hematopoietic stem cell transplantation. We report a 54-year-old man with acute myeloid lymphoma who underwent an allogeneic bone marrow transplantation and subsequently developed acute gastrointestinal GVHD 2 months post-transplantation and polymyositis 14 months post-transplantation. Upon tapering of steroids, the patient experienced a relapse of polymyositis. The literature on polymyositis in chronic GVHD is briefly reviewed.
authors: Cleveland Clinic Lerner College of Medicine and Department of Anatomic Pathology, Cleveland Clinic Main Campus, Mail Code L25, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
authors: Nematullah
authors: N
authors: Sharaf
authors: Cleveland Clinic Lerner College of Medicine and Department of Anatomic Pathology, Cleveland Clinic Main Campus, Mail Code L25, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Electronic address: praysor@ccf.org.
authors: Richard A
authors: RA
authors: Prayson
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D002908:Chronic Disease; D006086:Graft vs Host Disease / Q000150:complications* / Q000209:etiology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017285:Polymyositis / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D012008:Recurrence; D014184:Transplantation, Homologous
chemical_list: D000305:Adrenal Cortex Hormones
keywords: Bone marrow transplantation; Graft versus host disease; Polymyositis; Relapsing graft versus host disease