title: Cost savings with interventions to reduce aerosolized bronchodilator use in mechanically ventilated patients.
abstract: OBJECTIVE
  The purpose of this evaluation is to describe the cost savings associated with multimodal interventions aimed at reducing aerosolized bronchodilator use in mechanically ventilated patients without adversely affecting costs associated with length of stay (LOS).
  
  
  METHODS
  Subjects were included in the analysis if they were aged more than 18 years, on mechanical ventilation in the intensive care unit, and received aerosolized bronchodilators. Patients were excluded if they had reversible airway disease, an indication needing bronchodilator therapy. Patient data were obtained using the University Health System Consortium Clinical Data Base/Resource Manager (Chicago, IL) to compare outcomes during two 6-month periods separated by a 4-month intervention phase aimed to reduce bronchodilator use.
  
  
  RESULTS
  There were no significant differences in age, sex, and LOS (observed and expected) between the preintervention and postintervention phases. Based on whole acquisition costs, the total cost of bronchodilators dispensed to the adult intensive care units over the 6-month postintervention phase was reduced by $56960 compared with the 6-month preintervention phase ($120562 vs $63602, respectively).
  
  
  CONCLUSIONS
  Multimodal efforts to restrict aerosolized bronchodilator therapy in mechanically ventilated patients were successful and led to sustained reductions in use that was associated with substantial reductions in cost, without affecting LOS.
authors: University of Arizona Medical Center, Department of Pharmacy Services, Tucson, AZ; The University of Arizona College of Pharmacy, Department of Pharmacy Practice and Science, Tucson, AZ. Electronic address: james.camamo@uahealth.com.
authors: James M
authors: JM
authors: Camamo
authors: University of Arizona Medical Center, Department of Pharmacy Services, Tucson, AZ; The University of Arizona College of Pharmacy, Department of Pharmacy Practice and Science, Tucson, AZ.
authors: Kurt
authors: K
authors: Weibel
authors: University of Arizona Medical Center, Department of Pharmacy Services, Tucson, AZ; The University of Arizona College of Medicine, Tucson, AZ.
authors: Terence
authors: T
authors: O'Keeffe
authors: University of Arizona Medical Center, Department of Pharmacy Services, Tucson, AZ; The University of Arizona College of Pharmacy, Department of Pharmacy Practice and Science, Tucson, AZ.
authors: Yvonne
authors: Y
authors: Huckleberry
authors: University of Arizona Medical Center, Department of Pharmacy Services, Tucson, AZ; The University of Arizona College of Pharmacy, Department of Pharmacy Practice and Science, Tucson, AZ.
authors: Brian J
authors: BJ
authors: Kopp
authors: University of Arizona Medical Center, Department of Pharmacy Services, Tucson, AZ; The University of Arizona College of Medicine, Tucson, AZ.
authors: Conrad
authors: C
authors: Diven
authors: University of Arizona Medical Center, Department of Pharmacy Services, Tucson, AZ; The University of Arizona College of Pharmacy, Department of Pharmacy Practice and Science, Tucson, AZ.
authors: Brian L
authors: BL
authors: Erstad
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D000336:Aerosols; D000368:Aged; D001993:Bronchodilator Agents / Q000008:administration & dosage* / Q000191:economics*; D017046:Cost Savings; D005260:Female; D006801:Humans; D007362:Intensive Care Units / Q000191:economics; D007902:Length of Stay / Q000191:economics* / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D012121:Respiration, Artificial / Q000191:economics*; D012189:Retrospective Studies
chemical_list: D000336:Aerosols; D001993:Bronchodilator Agents
keywords: Bronchodilator; Cost savings; Mechanical ventilation