title: Biochemical alterations during the obese-aging process in female and male monosodium glutamate (MSG)-treated mice.
abstract: Obesity, from children to the elderly, has increased in the world at an alarming rate over the past three decades, implying long-term detrimental consequences for individual's health. Obesity and aging are known to be risk factors for metabolic disorder development, insulin resistance and inflammation, but their relationship is not fully understood. Prevention and appropriate therapies for metabolic disorders and physical disabilities in older adults have become a major public health challenge. Hence, the aim of this study was to evaluate inflammation markers, biochemical parameters and glucose homeostasis during the obese-aging process, to understand the relationship between obesity and health span during the lifetime. In order to do this, the monosodium glutamate (MSG) obesity mice model was used, and data were evaluated at 4, 8, 12, 16 and 20 months in both female and male mice. Our results showed that obesity was a major factor contributing to premature alterations in MSG-treated mice metabolism; however, at older ages, obesity effects were attenuated and MSG-mice became more similar to normal mice. At a younger age (four months old), the Lee index, triglycerides, total cholesterol, TNF-α and transaminases levels increased; while adiponectin decreased and glucose tolerance and insulin sensitivity levels were remarkably altered. However, from 16 months old-on, the Lee index and TNF-α levels diminished significantly, while adiponectin increased, and glucose and insulin homeostasis was recovered. In summary, MSG-treated obese mice showed metabolic changes and differential susceptibility by gender throughout life and during the aging process. Understanding metabolic differences between genders during the lifespan will allow the discovery of specific preventive treatment strategies for chronic diseases and functional decline.
authors: Post-Grade in Experimental Biology, Division of Health and Biological Sciences, Metropolitan Autonomous University, A.P. 55-535, D.F. Mexico, Mexico. mkf@xanum.uam.mx.
authors: René J
authors: RJ
authors: Hernández-Bautista
authors: Laboratory of Pharmacology, Department of Health Sciences, Division of Health and Biological Sciences, Metropolitan Autonomous University, A.P. 55-535, D.F. Mexico, Mexico. aaaf@xanum.uam.mx.
authors: Francisco J
authors: FJ
authors: Alarcón-Aguilar
authors: Laboratory of Pharmacology, Department of Health Sciences, Division of Health and Biological Sciences, Metropolitan Autonomous University, A.P. 55-535, D.F. Mexico, Mexico. mcev@xanum.uam.mx.
authors: María
authors: M
authors: Del C Escobar-Villanueva
authors: Laboratory of Pharmacology, Department of Health Sciences, Division of Health and Biological Sciences, Metropolitan Autonomous University, A.P. 55-535, D.F. Mexico, Mexico. jcap@xanum.uam.mx.
authors: Julio C
authors: JC
authors: Almanza-Pérez
authors: Laboratory of Pharmacology, Department of Health Sciences, Division of Health and Biological Sciences, Metropolitan Autonomous University, A.P. 55-535, D.F. Mexico, Mexico. mkf@xanum.uam.mx.
authors: Héctor
authors: H
authors: Merino-Aguilar
authors: Laboratory of Bioenergetics and Cellular Aging, Department of Health Sciences, Division of Health and Biological Sciences, Metropolitan Autonomous University, A.P. 55-535, D.F. Mexico, Mexico. mkf@xanum.uam.mx.
authors: Mina Konigsberg
authors: MK
authors: Fainstein
authors: Laboratory of Bioenergetics and Cellular Aging, Department of Health Sciences, Division of Health and Biological Sciences, Metropolitan Autonomous University, A.P. 55-535, D.F. Mexico, Mexico. norm@xanum.uam.mx.
authors: Norma E
authors: NE
authors: López-Diazguerrero
mesh_terms: D052242:Adiponectin / Q000097:blood; D000367:Age Factors; D000818:Animals; D002784:Cholesterol / Q000097:blood; D005260:Female; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D051379:Mice; D009765:Obesity / Q000209:etiology / Q000378:metabolism*; D012737:Sex Factors; D012970:Sodium Glutamate / Q000633:toxicity*; D000637:Transaminases / Q000097:blood; D014280:Triglycerides / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D052242:Adiponectin; D015850:Interleukin-6; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha; D002784:Cholesterol; D000637:Transaminases; D012970:Sodium Glutamate