title: White matter abnormalities in schizophrenia and schizotypal personality disorder.
abstract: Prior diffusion tensor imaging (DTI) studies examining schizotypal personality disorder (SPD) and schizophrenia, separately have shown that compared with healthy controls (HCs), patients show frontotemporal white matter (WM) abnormalities. This is the first DTI study to directly compare WM tract coherence with tractography and fractional anisotropy (FA) across the schizophrenia spectrum in a large sample of demographically matched HCs (n = 55), medication-naive SPD patients (n = 49), and unmedicated/never-medicated schizophrenia patients (n = 22) to determine whether (a) frontal-striatal-temporal WM tract abnormalities in schizophrenia are similar to, or distinct from those observed in SPD; and (b) WM tract abnormalities are associated with clinical symptom severity indicating a common underlying pathology across the spectrum. Compared with both the HC and SPD groups, schizophrenia patients showed WM abnormalities, as indexed by lower FA in the temporal lobe (inferior longitudinal fasciculus) and cingulum regions. SPD patients showed lower FA in the corpus callosum genu compared with the HC group, but this regional abnormality was more widespread in schizophrenia patients. Across the schizophrenia spectrum, greater WM disruptions were associated with greater symptom severity. Overall, frontal-striatal-temporal WM dysconnectivity is attenuated in SPD compared with schizophrenia patients and may mitigate the emergence of psychosis.
authors: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY;
authors: Marc S
authors: MS
authors: Lener
authors: Translational and Molecular Imaging Institute, Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY;
authors: Edmund
authors: E
authors: Wong
authors: Translational and Molecular Imaging Institute, Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY;
authors: Cheuk Y
authors: CY
authors: Tang
authors: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY; Mental Illness Research, Education, and Clinical Center (MIRECC VISN 3), James J. Peters Veterans Affairs Medical Center, Bronx, NY; Department of Outpatient Psychiatry, James J. Peters Veterans Affairs Medical Center, Bronx, NY;
authors: William
authors: W
authors: Byne
authors: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY;
authors: Kim E
authors: KE
authors: Goldstein
authors: Mental Illness Research, Education, and Clinical Center (MIRECC VISN 3), James J. Peters Veterans Affairs Medical Center, Bronx, NY; Research and Development, James J. Peters Veterans Affairs Medical Center, Bronx, NY.
authors: Nicholas J
authors: NJ
authors: Blair
authors: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY; Department of Outpatient Psychiatry, James J. Peters Veterans Affairs Medical Center, Bronx, NY;
authors: M Mehmet
authors: MM
authors: Haznedar
authors: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY; Mental Illness Research, Education, and Clinical Center (MIRECC VISN 3), James J. Peters Veterans Affairs Medical Center, Bronx, NY;
authors: Antonia S
authors: AS
authors: New
authors: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY; Department of Outpatient Psychiatry, James J. Peters Veterans Affairs Medical Center, Bronx, NY;
authors: Eran
authors: E
authors: Chemerinski
authors: Mental Illness Research, Education, and Clinical Center (MIRECC VISN 3), James J. Peters Veterans Affairs Medical Center, Bronx, NY; Research and Development, James J. Peters Veterans Affairs Medical Center, Bronx, NY.
authors: King-Wai
authors: KW
authors: Chu
authors: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY;
authors: Liza S
authors: LS
authors: Rimsky
authors: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY; Mental Illness Research, Education, and Clinical Center (MIRECC VISN 3), James J. Peters Veterans Affairs Medical Center, Bronx, NY; Department of Outpatient Psychiatry, James J. Peters Veterans Affairs Medical Center, Bronx, NY;
authors: Larry J
authors: LJ
authors: Siever
authors: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY; Department of Outpatient Psychiatry, James J. Peters Veterans Affairs Medical Center, Bronx, NY;
authors: Harold W
authors: HW
authors: Koenigsberg
authors: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY; Mental Illness Research, Education, and Clinical Center (MIRECC VISN 3), James J. Peters Veterans Affairs Medical Center, Bronx, NY; Research and Development, James J. Peters Veterans Affairs Medical Center, Bronx, NY erin.hazlett@mssm.edu.
authors: Erin A
authors: EA
authors: Hazlett
mesh_terms: D000328:Adult; D016880:Anisotropy; D001921:Brain / Q000473:pathology; D016022:Case-Control Studies; D056324:Diffusion Tensor Imaging; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D017072:Neostriatum / Q000473:pathology; D009434:Neural Pathways / Q000473:pathology; D012559:Schizophrenia / Q000473:pathology*; D012565:Schizophrenic Psychology; D012569:Schizotypal Personality Disorder / Q000473:pathology* / Q000523:psychology; D012720:Severity of Illness Index; D013702:Temporal Lobe / Q000473:pathology; D066127:White Matter / Q000473:pathology*; D055815:Young Adult
keywords: DTI; MRI; cingulum; genu; inferior longitudinal fasciculus; psychosis; schizophrenia; schizotypal personality disorder; white matter