title: Apotirucallane protolimonoids from the Chinese mangrove Xylocarpus granatum Koenig.
abstract: A series of previously unreported compounds including seven new apotirucallane protolimonoids, xylogranatumines A-G (1-7), were isolated together with three known analogues (8-10) from the twigs and leaves of the Chinese mangrove, Xylocarpus granatum. The structures of these new compounds were elucidated by extensive spectroscopic analysis including 1D and 2D NMR and high-resolution electrospray ionization mass spectrometry (HRESIMS) and by comparison with those of related known compounds in the literature. Xylogranatumine F (6) exhibited cytotoxic activity against A549 tumor cell in vitro.
authors: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zu Chong Zhi Road 555, Shanghai 201203, China.
authors: Zhen-Fang
authors: ZF
authors: Zhou
authors: Dipartimento di Farmacia, Università di Napoli 'Federico II', Via D. Montesano, 49, 80131 Napoli, Italy.
authors: Orazio
authors: O
authors: Taglialatela-Scafati
authors: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zu Chong Zhi Road 555, Shanghai 201203, China.
authors: Hai-Li
authors: HL
authors: Liu
authors: Syngenta Jealotts Hill International Research Centre, Berkshire RG42 6EY, United Kingdom.
authors: Yu-Cheng
authors: YC
authors: Gu
authors: State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. Electronic address: cpu_lykong@126.com.
authors: Ling-Yi
authors: LY
authors: Kong
authors: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zu Chong Zhi Road 555, Shanghai 201203, China. Electronic address: ywguo@simm.ac.cn.
authors: Yue-Wei
authors: YW
authors: Guo
mesh_terms: D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D029582:Meliaceae / Q000737:chemistry*; D015394:Molecular Structure; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D014315:Triterpenes; C000596997:xylogranatumine F
keywords: Apotirucallane; Cytotoxicity; Protolimonoid; Xylocarpus granatum