title: [A case of micafungin-hyposensitive Candida glabrata due to FKS2 gene mutation].
abstract: Candida glabrata was continuously isolated in cultured urine samples from a subject with thrombotic thrombocytopenic purpura. Yeast-like fungal phagocytosis found in gram staining led to agents being tested for antifungal susceptibility, revealing hyposensitivity to micafungin (MCFG) of MIC < 2 mg/mL. MCFG administered for 10 days failed to cure C. glabrata infection. To clarify why hyposensitivity occurred, we analyzed the FKS gene sequence using the PCR, finding a deficit of 3 bases coding phenylalanine at FKS2 gene amino acid 659. MCFG hyposensitivity may thus occur in long-term candin-class anti-fungal agent treatment. Candin-class agents have potent anti-fungal activity with fewer adverse effects and are widely used clinically. Hyposensitivity due to resistant C. glabrata species showed thus be considered in fungal infection treatment.
authors: Sachiko
authors: S
authors: Inui
authors: Tatsuya
authors: T
authors: Nakamura
authors: Kouichi
authors: K
authors: Tanabe
authors: Hideaki
authors: H
authors: Ohno
authors: Chihiro
authors: C
authors: Koike
authors: Kazuyuki
authors: K
authors: Okuda
authors: Chiyo
authors: C
authors: Nakata
authors: Hiroko
authors: H
authors: Fujimoto
authors: Hiroe
authors: H
authors: Ohkura
authors: Yoshitsugu
authors: Y
authors: Miyazaki
authors: Hakuo
authors: H
authors: Takahashi
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000494:pharmacology*; D041221:Candida glabrata / Q000187:drug effects* / Q000235:genetics*; D025141:Drug Resistance, Fungal; D054714:Echinocandins / Q000494:pharmacology*; D005260:Female; D005656:Fungal Proteins / Q000235:genetics; D005800:Genes, Fungal / Q000235:genetics*; D005964:Glucosyltransferases / Q000235:genetics; D006801:Humans; D055666:Lipopeptides / Q000494:pharmacology*; D008565:Membrane Proteins / Q000235:genetics; D000077551:Micafungin; D009154:Mutation
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D005656:Fungal Proteins; D055666:Lipopeptides; D008565:Membrane Proteins; D005964:Glucosyltransferases; D000077551:Micafungin