title: Evaluation of the Relationship Between Ischemia-Modified Albumin Levels and Thyroid Hormone Levels.
abstract: BACKGROUND
  A novel ischemia marker named ischemia modified albumin was previously considered as an early marker of myocardial ischemia, however due to recent reports, its contribution was demonstrated in different pathologies such as oxidative stress, diabetes, stroke and cancer. We aimed to investigate the relation between oxidative stress and thyroid dysfunctions determining IMA levels since IMA is closely related with increased oxidative stress.
  
  
  METHODS
  A total of 88 individuals were participated in this study: 34 cases in hypothyroid, 27 cases in hyperthyroid and 27 cases in euthyroid group. Ischemia-modified albumin levels were measured by albumin cobalt binding test and thyroid hormone levels were determined with electrochemiluminescent method.
  
  
  RESULTS
  Ischemia modified albumin levels were significantly decreased in hypothyroid group compared to hyperthyroid and euthyroid groups (p < 0.001). In hyperthyroid individuals ischemia modified albumin levels were higher compared to euthyroid ones (p < 0.001). Ischemia modified albumin was negatively correlated with TSH levels (r = -0.473, p < 0.001), and positively correlated with FT4 and FT3 levels (r = 0.496, p < 0.001 and r = 0.275, p = 0.010, respectively).
  
  
  CONCLUSIONS
  We suggest that albumin adjusted IMA levels are significantly lower in hypothyroid group than hyperthyroid and euthyroid groups.
authors: Department of Biochemistry, Faculty of Medicine, Mevlana University, Konya, Turkey.
authors: Mufide
authors: M
authors: Oncel
authors: Department of Biochemistry, Faculty of Medicine, Mevlana University, Konya, Turkey.
authors: Aysel
authors: A
authors: Kıyıcı
authors: Department of Internal Medicine, Beyhekim State Hospital, Konya, Turkey.
authors: Serife
authors: S
authors: Onen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood / Q000175:diagnosis*; D007037:Hypothyroidism / Q000097:blood / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D011379:Prognosis; D012709:Serum Albumin; D000075462:Serum Albumin, Human; D013963:Thyroid Hormones / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; D013963:Thyroid Hormones; C561522:ischemia-modified albumin; D000075462:Serum Albumin, Human
keywords: euthyroid; hyperthyroid; hypothyroid; ischemia-modified albumin; thyroid hormone levels