title: Protection against brain tissues oxidative damage as a possible mechanism for the beneficial effects of Rosa damascena hydroalcoholic extract on scopolamine induced memory impairment in rats.
abstract: OBJECTIVE
  Hypnotic, analgesic, anticonvulsant, and antioxidant effects of Rosa damascena have been reported. This study, investigated the effect of R. damascena hydroalcoholic extract on memory performance in a scopolamine-induced memory impairment model.
  
  
  METHODS
  The rats were divided into control group received just saline; scopolamine group was treated by saline for 2 weeks, but was injected by scopolamine 30 minutes before each trial in Morris water maze test; treatment groups (scopolamine + extract 50; Sco + Ext 50) and (scopolamine + extract 250; Sco + Ext 250) were daily treated by 50 and 250 mg/kg of R. damascena extract (2 weeks) and were finally injected by scopolamine before each trial in Morris water maze. The brains were removed for biochemical measurements.
  
  
  RESULTS
  Time latency and path length in the scopolamine group were higher than control (P < 0.01 to <0.001). Both treatment groups showed shorter traveled distance and time latency compared with scopolamine group (P < 0.05 to <0.001). Time spent in target quadrant by scopolamine group was lower than control (P < 0.05), while Sco + Ext 250 group spent longer time in target quadrant than scopolamine group (P < 0.05). Malondialdehyde concentrations in hippocampal and cortical tissues of scopolamine group were higher, while thiol concentrations were lower than control ones (P < 0.001). Treatment by both doses of the extract decreased the malondialdehyde concentration, while increased the thiol concentration (P < 0.05 to <0.001).
  
  
  CONCLUSIONS
  The results of this study showed that the hydroalcoholic extract of R. damascena prevents scopolamine-induced memory deficits. This finding suggests that memory improvement may be in part due to the antioxidant effects.
authors: Toktam
authors: T
authors: Mohammadpour
authors: Mahmoud
authors: M
authors: Hosseini
authors: Asieh
authors: A
authors: Naderi
authors: Reza
authors: R
authors: Karami
authors: Hamid Reza
authors: HR
authors: Sadeghnia
authors: Mohammad
authors: M
authors: Soukhtanloo
authors: Farzaneh
authors: F
authors: Vafaee
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde; D008568:Memory / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced / Q000188:drug therapy*; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D027826:Rosa / Q000737:chemistry*; D012601:Scopolamine / Q000633:toxicity*
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D008315:Malondialdehyde; D012601:Scopolamine
keywords: Memory; Morris water maze; Oxidative damage; Rosa damascena; Scopolamine