title: Drug co-loading and pH-sensitive release core-shell nanoparticles via layer-by-layer assembly.
abstract: Multifunctional core-shell nanoparticles are widely used for biomedical and catalytic applications. In this work, bilayers of chitosan (Cs) and phosphorylated polyvinyl alcohol (PPVA) were sequentially deposited on 3-Aminopropyltri-ethoxysilane-modified SiO2 nanoparticles via layer-by-layer electrostatic self-assembly. The good spherical shape and size distribution were observed by DLS and transmission electron microscope analysis. 7-Hydroxycoumarin (7-HC) and rhodamine B (RhB) as model drugs were loaded in the core and shell of the nanoparticles separately. Confocal laser scanning microscopy shows the core-shell structure of HC-SiO2(PPVA/Cs)n-RhB nanoparticles and the embedded location of 7-HC and RhB. The pH-sensitive release investigation of RhB indicates that the release profiles of RhB from HC-SiO2(PPVA/Cs)3PPVA-RhB core-shell nanoparticles are totally different at pH values of 2.0, 7.4, and 9.2. These results predict that the multifunctional nanoparticle SiO2(PPVA/Cs)n has a great potential for drug delivery.
authors: a School of Chemical Engineering and Technology , Tianjin University , Tianjin 300072 , China.
authors: Liang
authors: L
authors: Tian
authors: Jing
authors: J
authors: Yang
authors: Feng
authors: F
authors: Ji
authors: Yuxi
authors: Y
authors: Liu
authors: Fanglian
authors: F
authors: Yao
mesh_terms: D002214:Capsules; D048271:Chitosan / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D006863:Hydrogen-Ion Concentration; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D010316:Particle Size; D010766:Phosphorylation; D011142:Polyvinyl Alcohol / Q000737:chemistry; D012235:Rhodamines / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry; D014468:Umbelliferones / Q000737:chemistry
chemical_list: D002214:Capsules; D004337:Drug Carriers; D012235:Rhodamines; D014468:Umbelliferones; C031477:7-hydroxycoumarin; D012822:Silicon Dioxide; D011142:Polyvinyl Alcohol; D048271:Chitosan; C029773:rhodamine B
keywords: chitosan; co-loading; core–shell nanoparticle; layer-by-layer assembly; pH sensitive; phosphorylated polyvinyl alcohol; silica