title: Genomic and phylogenetic characterization of Shuni virus.
abstract: Shuni virus (SHUV), a member of the genus Orthobunyavirus, has in a recent study been associated with neurological disease in horses in South Africa. After its first isolation in 1966 from an asymptomatic bovine, very little attention was given to the genetic characterisation of SHUV. The association of SHUV with severe neurological disease in several horses in South Africa prompted us to determine the full genome sequence of a horse neurovirulent isolate to compare it to other members of the genus Orthobunyavirus, as well as the partially sequenced genome of the prototype SHUV strain. The availability of a full genome sequence will facilitate the development of a reverse genetics system to study SHUV molecular biology and pathogenesis.
authors: Zoonoses Research Unit, Department of Medical Virology, University of Pretoria, Pretoria, South Africa, charmaine.vaneeden@gmail.com.
authors: Charmaine
authors: C
authors: van Eeden
authors: Frank
authors: F
authors: Harders
authors: Jeroen
authors: J
authors: Kortekaas
authors: Alex
authors: A
authors: Bossers
authors: Marietjie
authors: M
authors: Venter
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002044:Bunyaviridae Infections / Q000662:veterinary* / Q000821:virology; D002417:Cattle; D002418:Cattle Diseases / Q000821:virology; D016679:Genome, Viral; D023281:Genomics; D006734:Horse Diseases / Q000821:virology*; D006736:Horses; D008969:Molecular Sequence Data; D016851:Orthobunyavirus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D010802:Phylogeny; D016415:Sequence Alignment; D013019:South Africa; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
chemical_list: D014764:Viral Proteins