title: Supercooling enables long-term transplantation survival following 4 days of liver preservation.
abstract: The realization of long-term human organ preservation will have groundbreaking effects on the current practice of transplantation. Herein we present a new technique based on subzero nonfreezing preservation and extracorporeal machine perfusion that allows transplantation of rat livers preserved for up to four days, thereby tripling the viable preservation duration.
authors: 1] Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. [2] Department of Surgery, University Medical Center, Utrecht, the Netherlands.
authors: Tim A
authors: TA
authors: Berendsen
authors: Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors: Bote G
authors: BG
authors: Bruinsma
authors: Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors: Catheleyne F
authors: CF
authors: Puts
authors: Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors: Nima
authors: N
authors: Saeidi
authors: Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors: O Berk
authors: OB
authors: Usta
authors: Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors: Basak E
authors: BE
authors: Uygun
authors: Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors: Maria-Louisa
authors: ML
authors: Izamis
authors: Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors: Mehmet
authors: M
authors: Toner
authors: 1] Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. [2] Department of Biomedical Engineering, Rutgers University, Piscataway, New Jersey, USA.
authors: Martin L
authors: ML
authors: Yarmush
authors: Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors: Korkut
authors: K
authors: Uygun
mesh_terms: D000818:Animals; D003080:Cold Temperature; D016031:Liver Transplantation; D009926:Organ Preservation; D051381:Rats; D015996:Survival Rate