title: MicroRNA-199a-3p and microRNA-34a regulate apoptosis in human osteosarcoma cells.
abstract: miRNAs (microRNAs) are small non-coding RNAs [18-25 nt (nucleotides)] that regulate gene expression mainly through affecting post-transcriptional modification. Osteosarcoma is an aggressive sarcoma of the bone characterized by a high level of genetic instability and recurrent DNA deletions and amplifications. miRNAs play an important role in cancer cell growth and migration; however, the potential roles of miRNAs in osteosarcoma remain largely uncharacterized. In this paper, miR-199a and miR-34a were discussed the mechanisms of apoptosis using miRNA mimics in human osteosarcoma cells. The results demonstrated that miR-199a and miR-34a could induce the apoptosis of human osteosarcoma cells via p53 signalling pathway.
authors: *Department of Orthopaedic Surgery, the Third Hospital of HeBei Medical University, Shijiazhuang, China.
authors: Ye
authors: Y
authors: Tian
authors: *Department of Orthopaedic Surgery, the Third Hospital of HeBei Medical University, Shijiazhuang, China.
authors: Ying-Ze
authors: YZ
authors: Zhang
authors: *Department of Orthopaedic Surgery, the Third Hospital of HeBei Medical University, Shijiazhuang, China.
authors: Wei
authors: W
authors: Chen
mesh_terms: D017209:Apoptosis / Q000235:genetics*; D001859:Bone Neoplasms / Q000235:genetics*; D045744:Cell Line, Tumor; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D012516:Osteosarcoma / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
chemical_list: C522425:MIRN34 microRNA, human; D035683:MicroRNAs; D016159:Tumor Suppressor Protein p53; C531408:mirn199 microRNA, human