title: Benzocoumarins: isolation, synthesis, and biological activities.
abstract: Benzocoumarins are coumarins with a phenyl group bonded to 3,4-, 5,6-, 6,7-, or 7,8-positions. Over the past years, significant efforts have been made not only to isolate the novel structural analogs of benzocoumarins with prominent bioactivities but also to design new synthetic methods to synthesize benzocoumarins with better or novel biological properties. The aim of this review is to provide the readers with an overview of the research progress of benzocoumarins from 1953 to May 2014, covering its isolation, synthesis, and biological activities.
authors: Hai-Ning
authors: HN
authors: Lv
authors: Peng-Fei
authors: PF
authors: Tu
authors: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China. yongjiang@bjmu.edu.cn.
authors: Yong
authors: Y
authors: Jiang
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D004396:Coloring Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D050171:Dyslipidemias / Q000188:drug therapy; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004965:Estrogen Antagonists / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004967:Estrogens / Q000378:metabolism; D006801:Humans; D007834:Lasers
chemical_list: D000890:Anti-Infective Agents; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D004396:Coloring Agents; D003374:Coumarins; D004791:Enzyme Inhibitors; D004965:Estrogen Antagonists; D004967:Estrogens