title: Copper homeostasis: specialized functions of the late secretory pathway.
abstract: Differentiated cells have evolved mechanisms to adapt the functions of the late secretory pathway to the specific needs of the organism. Reporting in this issue of Developmental Cell, Polishchuk et al. (2014) demonstrate that hepatocytes utilize a unique exocytic aspect of the late endosomal/lysosomal compartment to maintain organismal copper homeostasis.
authors: Marine Biological Laboratory, Woods Hole, MA 02543, USA. Electronic address: jgitlin@mbl.edu.
authors: Jonathan D
authors: JD
authors: Gitlin
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D027682:Cation Transport Proteins / Q000378:metabolism*; D003300:Copper / Q000378:metabolism*; D000073840:Copper-Transporting ATPases; D005089:Exocytosis / Q000502:physiology*; D006056:Golgi Apparatus / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D008247:Lysosomes / Q000378:metabolism*; D008297:Male
chemical_list: D027682:Cation Transport Proteins; D003300:Copper; D000251:Adenosine Triphosphatases; D000073840:Copper-Transporting ATPases