title: Aspirin hypersensitivity in patients with chronic rhinosinusitis and nasal polyposis: frequency and contributing factors.
abstract: BACKGROUND
  Aspirin-exacerbated respiratory disease (AERD) is a syndrome frequently seen in patients with chronic rhinosinusitis and nasal polyposis (CRSwNP). However, there are few studies on evaluating the prevalence of aspirin (acetylsalicylic acid [ASA]) hypersensitivity in patients with CRSwNP using the oral aspirin challenge (OAC) test. This cross-sectional study was designed to determine the frequency of ASA hypersensitivity and factors associated with it in patients with CRSwNP in Tehran, Iran.
  
  
  METHODS
  Adult patients with CRSwNP who were presented to the asthma and allergy clinic were recruited for the study. After confirming CRS and NP, OAC was performed to evaluate/confirm the diagnosis of ASA hypersensitivity. Atopic evaluation was performed using skin-prick test, nasal smear, blood eosinophil count, and serum total IgE.
  
  
  RESULTS
  Eighty Iranian patients (43 women and 37 men) with CRSwNP were enrolled (mean age, 38.9 ± 10.7 years). OAC was performed in all of the patients and 39 patients (48.8%) had a positive reaction; among them, 14 (35.8%) had a self-reported history of ASA hypersensitivity. Concomitant asthma, previous polyp surgery, high polyp score, and ASA hypersensitivity history were all associated with positive OAC (p < 0.05). Presence of AERD was not associated with age, stage of asthma, blood eosinophilia, nasal smear eosinophilia, and atopy.
  
  
  CONCLUSIONS
  ASA hypersensitivity is common in patients with CRSwNP in Tehran, Iran. Patients at risk for AERD should be evaluated for the presence of ASA hypersensitivity with ASA provocation challenge test to confirm the diagnosis.
authors: Department of Allergy and Immunology, Rasool-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
authors: Mohammad
authors: M
authors: Nabavi
authors: Hossein
authors: H
authors: Esmaeilzadeh
authors: Saba
authors: S
authors: Arshi
authors: Mohammad Hassan
authors: MH
authors: Bemanian
authors: Morteza
authors: M
authors: Fallahpour
authors: Ahmad
authors: A
authors: Bahrami
authors: Negar
authors: N
authors: Mortazavi
authors: Kamran
authors: K
authors: Kamrava
authors: Mohammad
authors: M
authors: Farhadi
authors: Reza
authors: R
authors: Taghipour
authors: Nima
authors: N
authors: Rezaei
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001241:Aspirin / Q000276:immunology; D055963:Asthma, Aspirin-Induced / Q000175:diagnosis / Q000453:epidemiology*; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012220:Rhinitis / Q000175:diagnosis / Q000453:epidemiology*; D012307:Risk Factors; D012852:Sinusitis / Q000175:diagnosis / Q000453:epidemiology*
chemical_list: D001241:Aspirin