title: Self-assembled asymmetric catalyst engaged in a continuous-flow platform: an anti-selective catalytic asymmetric nitroaldol reaction.
abstract: An anti-selective catalytic asymmetric nitroaldol reaction was manifested in a continuous-flow platform. The requisite Nd/Na heterogeneous catalyst was readily prepared by self-assembly of an amide-based chiral ligand, NdO1/5(O(i)Pr)13/5, NaHMDS, and a multiwalled carbon nanotube without covalent linkage. A stainless-steel column filled with the Nd/Na catalyst was incorporated in a flow system to promote the nitroaldol reaction with high stereoselectivity. The flow system with the heterogeneous catalyst obviated the quenching operation, and the cooling system was minimized.
authors: Institute of Microbial Chemistry (BIKAKEN), Tokyo , 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo 141-0021, Japan.
authors: Kazuki
authors: K
authors: Hashimoto
authors: Naoya
authors: N
authors: Kumagai
authors: Masakatsu
authors: M
authors: Shibasaki
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000577:Amides / Q000737:chemistry; D002384:Catalysis; D002625:Chemistry, Organic / Q000295:instrumentation / Q000379:methods; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry*; D015394:Molecular Structure; D037742:Nanotubes, Carbon / Q000737:chemistry; D009574:Nitro Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000577:Amides; D006575:Heterocyclic Compounds, 3-Ring; D037742:Nanotubes, Carbon; D009574:Nitro Compounds; C560828:nitroaldol