title: Implications of peritoneal lavage cytology in resectable left-sided pancreatic cancer.
abstract: OBJECTIVE
  The aim of this study was to determine the utility of the peritoneal lavage cytology findings in predicting the clinical outcomes of resectable left-sided pancreatic cancer.
  
  
  METHODS
  Peritoneal lavage samples were collected from 39 consecutive patients who underwent surgery for left-sided pancreatic cancer between January 2000 and December 2010. We analyzed the correlations between the peritoneal lavage cytology findings and the clinical outcomes.
  
  
  RESULTS
  Five patients (12.8 %) had malignant cells in the cytology samples (positive cytology). This occurred more frequently in patients with vascular invasion (P = 0.008). Positive cytology was significantly associated with lower overall (P = 0.0007) and recurrent-free (P < 0.0001) survival rates. Positive cytology was an independent prognostic factor for recurrence (P = 0.022); it was closely associated with local recurrence, peritoneal recurrence and distant metastasis.
  
  
  CONCLUSIONS
  Surgeons should carefully consider the intraoperative diagnosis of peritoneal lavage cytology in patients with resectable left-sided pancreatic cancers, because patients with positive cytology are likely to experience recurrence.
authors: Department of Surgery, Graduate School of Medicine, Osaka University, Yamadaoka 2-2 (E2), Suita, Osaka, 565-0871, Japan, yiwagami@gesurg.med.osaka-u.ac.jp.
authors: Yoshifumi
authors: Y
authors: Iwagami
authors: Hidetoshi
authors: H
authors: Eguchi
authors: Hiroshi
authors: H
authors: Wada
authors: Yoshito
authors: Y
authors: Tomimaru
authors: Naoki
authors: N
authors: Hama
authors: Koichi
authors: K
authors: Kawamoto
authors: Shogo
authors: S
authors: Kobayashi
authors: Masaki
authors: M
authors: Mori
authors: Yuichiro
authors: Y
authors: Doki
authors: Hiroaki
authors: H
authors: Nagano
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D021441:Carcinoma, Pancreatic Ductal / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D015331:Cohort Studies; D003581:Cytodiagnosis / Q000379:methods*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy / Q000379:methods; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D010533:Peritoneal Lavage / Q000379:methods*; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D016896:Treatment Outcome