title: Effect of hemodialysis on pulmonary function tests and plasma endothelin levels.
abstract: End-stage renal disease (ESRD) is a complex illness that involves different organs including the lungs. We studied the pulmonary function tests, arterial blood gases (ABG) and plasma endothelin-1 (ET-1) levels to check whether there is any change in their levels after hemodialysis (HD) in patients with ESRD. In this cross-sectional study (from July 2009 to April 2010), 20 patients with ESRD were evaluated. ABG, spirometric parameters and plasma ET-1 were measured before and after HD in these patients. Student's t-test was performed to clarify the differences and Pearson's test was used for correlations. P <0.05 was considered statistically significant. Significant reduction was seen in oxygen saturation (O₂sat), partial pressure of carbon-dioxide (PaCO₂) and oxygen (PaO₂) after a HD session (P <0.001). Also, improvement was seen in all spirometric parameters except forced expiratory volume (FEV1)/forced vital capacity (FVC) after HD. Plasma ET-1 levels decreased significantly after HD. Mean ET-1 before HD was 6.88 + 5.81 pg/mL while it was 3.91 + 2.76 pg/mL after HD (P = 0.009). Based on the plasma levels of ET-1, the patients were divided into two groups. The mean level of ET-1 was higher in the first group. Significant increase was seen in spirometric parameters in the second group. Our study suggests that, in patients with ESRD, plasma ET-1 level is higher than in the normal population, and this is closely related to deterioration of pulmonary function tests. Significant reduction of plasma ET-1 may be an important factor in the improvement of spiro-metry parameters after HD.
authors: Javid
authors: J
authors: Safa
authors: Chronic Kidney Disease Research Center, Department of Nephrology, Sina Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Hamid
authors: H
authors: Noshad
authors: Khalil
authors: K
authors: Ansarin
authors: Alireza
authors: A
authors: Nikzad
authors: Parviz
authors: P
authors: Saleh
authors: Abdolmohammad
authors: A
authors: Ranjbar
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001784:Blood Gas Analysis; D003430:Cross-Sectional Studies; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D008168:Lung / Q000503:physiopathology*; D008171:Lung Diseases / Q000097:blood / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D020127:Recovery of Function; D006435:Renal Dialysis / Q000009:adverse effects*; D012129:Respiratory Function Tests; D016896:Treatment Outcome; D014797:Vital Capacity; D055815:Young Adult
chemical_list: D015415:Biomarkers; D019332:Endothelin-1