title: [The basic functions of inosine 5'-monophosphate dehydrogenase and its application in drug discovery].
abstract: Inosine 5'-monophosphate dehydrogenase (IMPDH) is a key enzyme of de novo GMP biosynthesis. The expression and activity of IMPDH can be affected by diseases and physiological process. It is the drug target for anticancer, antiviral, antimicrobial and immunosuppressive therapeutics. Not only catalytic action but the other biological functions of IMPDH also play an important role in diseases. The basic functions, mechanism of catalysis, classification of inhibitors, biological functions and the latest advances to IMPDH will be illustrated in this review. It is expected to be helpful to the discovery of new inhibitors and biological functions of IMPDH.
authors: You-Wen
authors: YW
authors: Zhang
authors: Dan
authors: D
authors: Zhang
authors: Hua
authors: H
authors: Sun
mesh_terms: D000818:Animals; D001665:Binding Sites; D002384:Catalysis; D015195:Drug Design; D055808:Drug Discovery; D004791:Enzyme Inhibitors / Q000145:classification* / Q000494:pharmacology; D006801:Humans; D007168:IMP Dehydrogenase / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D007291:Inosine Monophosphate / Q000378:metabolism; D015394:Molecular Structure; D009243:NAD / Q000378:metabolism; D011110:Polymorphism, Genetic
chemical_list: D004791:Enzyme Inhibitors; D009243:NAD; D007291:Inosine Monophosphate; D007168:IMP Dehydrogenase; C488211:IMPDH1 protein, human; C501687:IMPDH2 protein, human