title: Serotonin transporter gene: a new polymorphism may affect response to antidepressant treatments in major depressive disorder.
abstract: OBJECTIVE
  Several gene variants have been related to major depressive disorder (MDD) treatment outcomes; however, few studies have investigated a possible different effect on pharmacotherapy and brief psychotherapy response.
  
  
  METHODS
  A total of 137 MDD patients were randomized to either interpersonal counseling (IPC; n = 40) or antidepressant pharmacological treatment (n = 97). Outcomes were remission, response, and symptom improvement at week 8. Five genetic variants were investigated (5HTR2A rs6314, BDNF rs6265, SLC6A4 rs8076005, CREB1 rs2253206, and TPH2 rs11179023) as possible modulators of outcomes.
  
  
  RESULTS
  The LC6A4 rs8076005 AA genotype and A allele were associated with response rate in the antidepressant group (p = 0.015 and 0.005, respectively) and in the whole sample (p = 0.03 and 0.02, respectively). In the IPC group a non-significant trend in the same direction was observed. The TPH2 rs11179023 A allele showed a marginal association with symptom improvement in the IPC group only. Other gene variants did not impact on outcomes in any treatment group.
  
  
  CONCLUSIONS
  Our study suggests that rs8076005 in the SLC6A4 gene may be a modulator of antidepressant response, especially when pharmacological treatment is used.
authors: Department of Biomedical and Neuromotor Sciences, University of Bologna, Viale Carlo Pepoli 5, 40123, Bologna, Italy.
authors: Yoshihiko
authors: Y
authors: Matsumoto
authors: Chiara
authors: C
authors: Fabbri
authors: Silvia
authors: S
authors: Pellegrini
authors: Stefano
authors: S
authors: Porcelli
authors: Pierluigi
authors: P
authors: Politi
authors: Silvio
authors: S
authors: Bellino
authors: Caterina
authors: C
authors: Iofrida
authors: Veronica
authors: V
authors: Mariotti
authors: Erika
authors: E
authors: Melissari
authors: Marco
authors: M
authors: Menchetti
authors: Valentina
authors: V
authors: Martinelli
authors: Marco
authors: M
authors: Cappucciati
authors: Paola
authors: P
authors: Bozzatello
authors: Elena
authors: E
authors: Brignolo
authors: Paolo
authors: P
authors: Brambilla
authors: Matteo
authors: M
authors: Balestrieri
authors: Alessandro
authors: A
authors: Serretti
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003376:Counseling; D003865:Major Depressive Disorder / Q000235:genetics* / Q000628:therapy*; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D016896:Treatment Outcome; D014365:Tryptophan Hydroxylase / Q000235:genetics*; D055815:Young Adult
chemical_list: D000928:Antidepressive Agents; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; C494784:TPH2 protein, human; D014365:Tryptophan Hydroxylase