title: TRPs and pain.
abstract: Pain usually occurs as a result of tissue damage and has a role in healing and protection. However, in certain conditions it has no functional purpose and can become chronic and debilitating. A demand for more effective treatments to deal with this highly prevalent problem requires a better understanding of the underlying mechanisms. TRP channels are associated with numerous sensory functions across a wide range of species. Investigation into the expression patterns, electrophysiological properties and the effects of channel deletion in transgenic animal models have produced a great deal of evidence linking these channels to transduction of noxious stimuli as well as signalling within the pain system.
authors: Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London, WC1E 6BT, UK, jane.sexton.09@ucl.ac.uk.
authors: Jane E
authors: JE
authors: Sexton
authors: Jeffrey
authors: J
authors: Vernon
authors: John N
authors: JN
authors: Wood
mesh_terms: D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D003080:Cold Temperature; D006358:Hot Temperature; D006801:Humans; D059225:Nociception; D010146:Pain / Q000503:physiopathology*; D015398:Signal Transduction / Q000502:physiology; D050051:Transient Receptor Potential Channels / Q000502:physiology*
chemical_list: D000700:Analgesics; D050051:Transient Receptor Potential Channels