title: Phenoxyacetohydrazide Schiff bases: β-glucuronidase inhibitors.
abstract: Phenoxyacetohydrazide Schiff base analogs 1-28 have been synthesized and their in vitro β-glucouoronidase inhibition potential studied. Compounds 1 (IC50=9.20±0.32 µM), 5 (IC50=9.47±0.16 µM), 7 (IC50=14.7±0.19 µM), 8 (IC50=15.4±1.56 µM), 11 (IC50=19.6±0.62 µM), 12 (IC50=30.7±1.49 µM), 15 (IC50=12.0±0.16 µM), 21 (IC50=13.7±0.40 µM) and 22 (IC50=22.0±0.14 µM) showed promising β-glucuronidase inhibition activity, better than the standard (D-saccharic acid-1,4-lactone, IC50=48.4±1.25 µM).
authors: Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. waqas143kh@yahoo.com.
authors: Waqas
authors: W
authors: Jamil
authors: Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. sarosh.iqbal@yahoo.com.
authors: Shagufta
authors: S
authors: Perveen
authors: Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, Bandar Puncak Alam, Selangor Darul Ehsan 42300, Malaysia. syedadnan@salam.uitm.edu.my.
authors: Syed Adnan Ali
authors: SA
authors: Shah
authors: Atta-ur-Rahman Institute for Natural Products Discovery (AuRIns), Level 9, FF3, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, Bandar Puncak Alam, Selangor Darul Ehsan 42300, Malaysia. taha_hej@yahoo.com.
authors: Muhammad
authors: M
authors: Taha
authors: Atta-ur-Rahman Institute for Natural Products Discovery (AuRIns), Level 9, FF3, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, Bandar Puncak Alam, Selangor Darul Ehsan 42300, Malaysia. norhadiani@puncakalam.uitm.edu.my.
authors: Nor Hadiani
authors: NH
authors: Ismail
authors: PCSIR Laboratories Complex, Shahrah-e-Dr. Salimuzzaman, Karachi 75280, Pakistan. shamim_302@yahoo.com.
authors: Shahnaz
authors: S
authors: Perveen
authors: Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. nida_mishi2002@yahoo.com.
authors: Nida
authors: N
authors: Ambreen
authors: Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. khalid.khan@iccs.edu.
authors: Khalid M
authors: KM
authors: Khan
authors: Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. hassaan2@super.net.pk.
authors: Muhammad I
authors: MI
authors: Choudhary
mesh_terms: D000818:Animals; D002417:Cattle; D004791:Enzyme Inhibitors / Q000737:chemistry*; D005966:Glucuronidase / Q000037:antagonists & inhibitors* / Q000737:chemistry; D006834:Hydrazines / Q000737:chemistry*; D010642:Phenoxyacetates / Q000737:chemistry*; D012545:Schiff Bases
chemical_list: D004791:Enzyme Inhibitors; D006834:Hydrazines; D010642:Phenoxyacetates; D012545:Schiff Bases; D005966:Glucuronidase