title: Predictive factors for masticatory performance in Duchenne muscular dystrophy.
abstract: Patients with Duchenne muscular dystrophy (DMD) report masticatory and swallowing problems. Such problems may cause complications such as choking, and feeling of food sticking in the throat. We investigated whether masticatory performance in DMD is objectively impaired, and explored predictive factors for compromised mastication. Twenty-three patients and 23 controls filled out two questionnaires about mandibular function, and underwent a clinical examination of the masticatory system and measurements of anterior bite force and masticatory performance. In the patients, moreover, quantitative ultrasound of the tongue and motor function measurement was performed. The patients were categorized into ambulatory stage (early or late), early non-ambulatory stage, or late non-ambulatory stage. Masticatory performance, anterior bite force and occlusal contacts were all reduced in the patient group compared to the controls (all p < 0.001). Mastication abnormalities were present early in the disease process prior to a reduction of motor function measurement. The early non-ambulatory and late non-ambulatory stage groups showed less masticatory performance compared to the ambulatory stage group (p < 0.028 and p < 0.010, respectively). Multiple linear regression analysis revealed that stage of the disease was the strongest independent risk factor for the masticatory performance (R(2) = 0.52). Anterior bite force, occlusal contacts and masticatory performance in DMD are severely reduced.
authors: Department of Oral Function and Prosthetic Dentistry, College of Dental Science, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Oral-Maxillofacial Surgery, Prosthodontics and Special Dental Care, University Medical Center Utrecht, The Netherlands. Electronic address: Willemijn.vanBruggen@radboudumc.nl.
authors: H W
authors: HW
authors: van Bruggen
authors: Department of Rehabilitation, Radboud University Medical Center, Nijmegen, The Netherlands.
authors: L
authors: L
authors: van de Engel-Hoek
authors: Department of Oral Function and Prosthetic Dentistry, College of Dental Science, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Oral-Maxillofacial Surgery, Prosthodontics and Special Dental Care, University Medical Center Utrecht, The Netherlands.
authors: M H
authors: MH
authors: Steenks
authors: Department of Preventive and Restorative Dentistry, College of Dental Science, Radboud University Medical Center, Nijmegen, The Netherlands.
authors: E M
authors: EM
authors: Bronkhorst
authors: Department of Oral Function and Prosthetic Dentistry, College of Dental Science, Radboud University Medical Center, Nijmegen, The Netherlands.
authors: N H J
authors: NH
authors: Creugers
authors: Department of Rehabilitation, Radboud University Medical Center, Nijmegen, The Netherlands.
authors: I J M
authors: IJ
authors: de Groot
authors: Department of Oral Function and Prosthetic Dentistry, College of Dental Science, Radboud University Medical Center, Nijmegen, The Netherlands.
authors: S I
authors: SI
authors: Kalaykova
mesh_terms: D000293:Adolescent; D000328:Adult; D001732:Bite Force; D016022:Case-Control Studies; D002648:Child; D015331:Cohort Studies; D018450:Disease Progression; D006801:Humans; D016014:Linear Models; D008297:Male; D008409:Mastication; D009055:Mouth / Q000000981:diagnostic imaging / Q000503:physiopathology; D020388:Muscular Dystrophy, Duchenne / Q000000981:diagnostic imaging / Q000503:physiopathology*; D010808:Physical Examination; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014463:Ultrasonography; D055815:Young Adult
keywords: Bite force; Duchenne muscular dystrophy; Masticatory performance; Masticatory system