title: Effect of HLA on hepatitis C virus clearance and persistence in anti-HCV-positive end-stage renal disease patients.
abstract: OBJECTIVE
  The efficacy of immune response against hepatitis C virus (HCV) is determined by human leukocyte antigen (HLA) molecules of the host which present HCV antigens to CD4 + and CD8 + T lymphocytes. In this study, we aimed to investigate the possible relationship between the frequencies of certain HLA class I-II alleles and the natural history of HCV in patients with end-stage renal disease (ESRD).
  
  
  METHODS
  This is a retrospective cohort study conducted in a university hospital.
  
  
  METHODS
  The present study comprised 189 ESRD patients (candidates for renal transplantation) who had positive anti-HCV antibody test. The results concerning HCV and HLA status were gathered from patients' files. The viral persistence was compared between the groups that were determined by HLA sub-typing.
  
  
  METHODS
  Statistical evaluation was performed using Mann-Whitney U-test, Chi-square test, and Fisher's exact test. Level of error was set at 0.05 for all statistical evaluations, and P values < 0.05 were considered statistically significant.
  
  
  RESULTS
  We found possible association between the course of HCV infection and specific HLA alleles. HLA class I CwFNx016 and HLA class II DRBFNx0110 alleles were observed more frequently in the viral clearance group (P < 0.05). The HLA class I BFNx0138 allele group was more prone to develop chronic hepatitis C (P < 0.01).
  
  
  CONCLUSIONS
  These findings suggest that HLA class I CwFNx016 and HLA class II DRBFNx0110 alleles may be associated with immunological elimination of HCV in Turkish patients on hemodialysis. HLA sub-typing could help predict the prognosis of HCV infection.
authors: Department of Gastroenterology, Baskent University, Faculty of Medicine, Ankara, Turkey.
authors: Serkan
authors: S
authors: Ocal
authors: Haldun
authors: H
authors: Selcuk
authors: Murat
authors: M
authors: Korkmaz
authors: Reskan
authors: R
authors: Altun
authors: Abdullah E
authors: AE
authors: Yildirim
authors: Enver
authors: E
authors: Akbas
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D016009:Chi-Square Distribution; D015331:Cohort Studies; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D016174:Hepacivirus / Q000276:immunology*; D006526:Hepatitis C / Q000453:epidemiology / Q000276:immunology*; D006801:Humans; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D012737:Sex Factors; D018709:Statistics, Nonparametric; D014421:Turkey; D019562:Viral Load / Q000276:immunology*
chemical_list: D006680:HLA Antigens