title: [Minocycline for schizophrenia: a brief overview].
abstract: BACKGROUND
  The tetracyclic antibiotic minocycline appears to have positive results when added to the the treatment prescribed for persistent symptoms of schizophrenia.
  
  
  OBJECTIVE
  To provide an overview of the literature on minocycline and schizophrenia.
  
  
  METHODS
  PubMed, up to September 2013, was scanned for articles relating to minocycline and schizophrenia.
  
  
  RESULTS
  We found seven case reports with regard to the use of minocycline as an additive in the treatment of persistent schizophrenia. Furthermore, an open-label study and two randomised placebo-controlled studies regarding this addition were published. Using minocycline may add to the improvement of negative symptoms and cognition in patients with schizophrenia.
  
  
  CONCLUSIONS
  It is concluded, albeit somewhat cautiously, that minocycline may be helpful in treating negative and cognitive symptoms in schizophrenia.
authors: J E
authors: JE
authors: Hovens
authors: T A M
authors: TA
authors: Onderwater
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use*; D003071:Cognition / Q000187:drug effects*; D006801:Humans; D008911:Minocycline / Q000627:therapeutic use*; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology
chemical_list: D014150:Antipsychotic Agents; D008911:Minocycline