title: Pricing and reimbursement frameworks in Central Eastern Europe: a decision tool to support choices.
abstract: OBJECTIVE
  Given limited financial resources in the Central Eastern European (CEE) region, challenges in obtaining access to innovative medical technologies are formidable. The objective of this research was to develop a decision tree that supports decision makers and drug manufacturers from CEE region in their search for optimal innovative pricing and reimbursement scheme (IPRSs).
  
  
  METHODS
  A systematic literature review was performed to search for published IPRSs, and then ten experts from the CEE region were interviewed to ascertain their opinions on these schemes.
  
  
  RESULTS
  In total, 33 articles representing 46 unique IPRSs were analyzed. Based on our literature review and subsequent expert input, key decision nodes and branches of the decision tree were developed.
  
  
  CONCLUSIONS
  The results indicate that outcome-based schemes are better suited to deal with uncertainties surrounding cost effectiveness, while non-outcome-based schemes are more appropriate for pricing and budget impact challenges.
authors: Department of Pharmacoeconomics, Warsaw Medical University, Warazawz, Poland.
authors: Katarzyna
authors: K
authors: Kolasa
authors: Zoltan
authors: Z
authors: Kalo
authors: Edward
authors: E
authors: Hornby
mesh_terms: D003362:Cost-Benefit Analysis; D003365:Costs and Cost Analysis; D003657:Decision Making; D003663:Decision Trees; D004345:Drug Industry / Q000191:economics*; D005061:Europe, Eastern; D006297:Health Services Accessibility / Q000191:economics*; D006801:Humans; D012051:Reimbursement Mechanisms / Q000191:economics*
keywords: Central Eastern European region; budget impact; cost effectiveness; innovative pricing and reimbursement schemes