title: Increased plasma DPP4 activities predict new-onset atherosclerosis in association with its proinflammatory effects in Chinese over a four year period: A prospective study.
abstract: OBJECTIVE
  DPP4, a novel proinflammatory cytokine, is involved in the inflammatory process through its interaction with IGF-II/M6P receptor. We aimed to investigate whether it could predict new-onset atherosclerosis in Chinese.
  
  
  METHODS
  A prospective study was conducted of 590 adults (213 men and 377 women) aged 18-70 years without atherosclerosis examined in 2007(baseline) and 2011(follow-up). Circulating DPP4 activity, inflammatory markers, IGF-II/M6P receptor and common carotid artery Intima-Media Thickness (C-IMT) were measured at baseline and four years later.
  
  
  RESULTS
  At baseline, individuals in the highest quartile of DPP4 activity had higher age, WHR, BMI, SBP, fasting insulin, 2h-PG, TG, LDL-C, IL-6, hs-CRP, IGF-II/M6P-R, C-IMT and lower HDL-C compared with individuals in the lowest quartile. After a 4-year follow-up, 71 individuals developed atherosclerosis. In multiple linear regression analysis, baseline DPP4 activity was an independent predictor of an increase in inflammatory markers, IGF-II/M6P receptor, and C-IMT over a 4-year period (all P < 0.01). In multivariable-adjusted models, the odds ratio (OR) for incident atherosclerosis comparing the highest with the lowest quartiles of DPP4 activity was 3.17 (95%CI 1.33-7.58) after adjustment for confounding risk factors (P = 0.009). The incidence of atherosclerosis owing to DPP4 activity increased by 12.41%.
  
  
  CONCLUSIONS
  DPP4 activity is an important predictor of the onset of inflammation and atherosclerosis in apparently healthy Chinese. This finding may have important implications for understanding the proinflammatory role of DPP-4 in the pathogenesis of atherosclerosis.
authors: Department of Endocrinology and Metabolism, Affiliated Hospital of Guilin Medical University, Guangxi, PR China. Electronic address: w19831120@126.com.
authors: T P
authors: TP
authors: Zheng
authors: Department of Endocrinology and Metabolism, Affiliated Hospital of Guilin Medical University, Guangxi, PR China. Electronic address: tottina@126.com.
authors: F
authors: F
authors: Yang
authors: Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, Sichuan, PR China.
authors: Y
authors: Y
authors: Gao
authors: Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, Sichuan, PR China.
authors: A
authors: A
authors: Baskota
authors: Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, Sichuan, PR China.
authors: T
authors: T
authors: Chen
authors: Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, Sichuan, PR China.
authors: H M
authors: HM
authors: Tian
authors: Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, Sichuan, PR China.
authors: X W
authors: XW
authors: Ran
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D050197:Atherosclerosis / Q000453:epidemiology / Q000473:pathology*; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging; D059168:Carotid Intima-Media Thickness; D002681:China / Q000453:epidemiology; D018819:Dipeptidyl Peptidase 4 / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007249:Inflammation / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: C042807:DPP4 protein, human; D018819:Dipeptidyl Peptidase 4
keywords: Atherosclerosis; C-IMT; DPP4 activity; Inflammation