title: Crosstalk between DNA repair and cancer stem cell (CSC) associated intracellular pathways.
abstract: DNA damaging agents (ionizing radiation and chemotherapeutics) are considered as most effective in cancer treatment. However, there is a subpopulation of carcinoma cells within the tumour demonstrating resistance to DNA damaging treatment approaches. It is suggested that limited tumour response to this kind of therapy can be associated with specific molecular properties of carcinoma stem cells (CSCs) representing the most refractory cell subpopulation. This review article presents novel data about molecular features of CSCs underlying DNA damage response and related intracellular signalling.
authors: Department of Therapeutic Radiology and Oncology, Innsbruck Medical University, Innsbruck, Austria. Electronic address: Sergej.Skvortsov@i-med.ac.at.
authors: Sergej
authors: S
authors: Skvortsov
authors: Department of Anatomy, Histology and Embryology, Innsbruck Medical University, Innsbruck, Austria.
authors: Paul
authors: P
authors: Debbage
authors: Department of Therapeutic Radiology and Oncology, Innsbruck Medical University, Innsbruck, Austria.
authors: Peter
authors: P
authors: Lukas
authors: Department of Therapeutic Radiology and Oncology, Innsbruck Medical University, Innsbruck, Austria.
authors: Ira
authors: I
authors: Skvortsova
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D004249:DNA Damage; D004260:DNA Repair; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase / Q000235:genetics / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D008957:Models, Genetic; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics*
chemical_list: D000970:Antineoplastic Agents; C085108:APEX1 protein, human; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase
keywords: Ape1/Ref-1; Cancer stem cells; DNA repair; Intracellular signalling; MRN complex