title: Cognitive-behavioral therapy for hypochondriasis/health anxiety: a meta-analysis of treatment outcome and moderators.
abstract: The present investigation employed meta-analysis to examine the efficacy of cognitive-behavioral therapy (CBT) for hypochondriasis/health anxiety as well as potential moderators that may be associated with outcome. A literature search revealed 15 comparisons among 13 randomized-controlled trials (RCTs) with a total sample size of 1081 participants that met inclusion criteria. Results indicated that CBT outperformed control conditions on primary outcome measures at post-treatment (Hedges's g = 0.95) and at follow-up (Hedges's g = 0.34). CBT also outperformed control conditions on measures of depression at post-treatment (Hedges's g = 0.64) and at follow-up (Hedges's g = 0.35). Moderator analyses revealed that higher pre-treatment severity of hypochondriasis/health anxiety was associated with greater effect sizes at follow-up visits and depression symptom severity was significantly associated with a lower in effect sizes at post-treatment. Although effect size did not vary as a function of blind assessment, smaller effect sizes were observed for CBT vs. treatment as usual control conditions than for CBT vs. waitlist control. A dose response relationship was also observed, such that a greater number of CBT sessions was associated with larger effect sizes at post-treatment. This review indicates that CBT is efficacious in the treatment of hypochondriasis/health anxiety and identifies potential moderators that are associated with outcome. The implications of these findings for further delineating prognostic and prescriptive indicators of CBT for hypochondriasis/health anxiety are discussed.
authors: Department of Psychology, Vanderbilt University, United States. Electronic address: olubunmi.o.olatunji@vanderbilt.edu.
authors: Bunmi O
authors: BO
authors: Olatunji
authors: Department of Psychology, University of Texas-Austin, United States.
authors: Brooke Y
authors: BY
authors: Kauffman
authors: Department of Psychology, Vanderbilt University, United States.
authors: Sari
authors: S
authors: Meltzer
authors: Department of Psychology, University of Texas-Austin, United States.
authors: Michelle L
authors: ML
authors: Davis
authors: Department of Psychology, University of Texas-Austin, United States.
authors: Jasper A J
authors: JA
authors: Smits
authors: Department of Psychology, University of Texas-Austin, United States.
authors: Mark B
authors: MB
authors: Powers
mesh_terms: D000328:Adult; D000368:Aged; D015928:Cognitive Behavioral Therapy; D003863:Depression / Q000150:complications / Q000628:therapy; D006801:Humans; D006998:Hypochondriasis / Q000150:complications / Q000628:therapy*; D008875:Middle Aged; D008960:Models, Psychological; D016896:Treatment Outcome
keywords: Cognitive-behavioral therapy; Health anxiety; Hypochondriasis; Moderation