title: Seroprevalence of human herpesvirus 8 and hepatitis C virus among drug users in Shanghai, China.
abstract: To elucidate and compare the seroprevalence of human herpesvirus 8 (HHV8) and hepatitis C virus (HCV) among Chinese drug users, a cross-sectional study of 441 participants, was conducted in Shanghai, China, from 2012 through 2013. Seventy-seven (17.5%) participants were found to be positive for HHV8 antibodies, while 271 (61.5%) participants were positive for HCV. No significant association between HHV8 seropositivity and drug use characteristics, sexual behaviors, HCV, or syphilis was observed. In contrast, a statistically significant association between HCV seropositivity and injected drug history (OR, 2.18, 95% CI 1.41-3.37) was detected, whereas no statistically significant association between HCV seropositivity and syphilis infection (OR, 7.56, 95% CI 0.94-60.57) were observed. Pairwise comparisons showed no significant differences between latent and lytic antibodies regarding HCV and HHV8 serostatus. The study demonstrated a moderate but elevated prevalence of HHV8 infection among drug users. The discordance between HHV8 and HCV infections suggests that blood borne transmission of HHV8 might not be the predominant mode of transmission in this population, which is in contrast to HCV.
authors: Department of Epidemiology, School of Public Health, Fudan University, and The Key Laboratory of Public Health Safety of Ministry of Education, Shanghai 200032, China. tjzhang@shmu.edu.cn.
authors: Tiejun
authors: T
authors: Zhang
authors: Department of Epidemiology, School of Public Health, Fudan University, and The Key Laboratory of Public Health Safety of Ministry of Education, Shanghai 200032, China. hailingilei@126.com.
authors: Ying
authors: Y
authors: Liu
authors: Putuo District Center for Disease Control and Prevention, Shanghai 200032, China. zhangyy1@shpt.gov.cn.
authors: Yuyan
authors: Y
authors: Zhang
authors: Department of Epidemiology, School of Public Health, Fudan University, and The Key Laboratory of Public Health Safety of Ministry of Education, Shanghai 200032, China. 13211020065@fudan.edu.cn.
authors: Jun
authors: J
authors: Wang
authors: Nebraska Center for Virology, School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA. vminhas2@unl.edu.
authors: Veenu
authors: V
authors: Minhas
authors: Nebraska Center for Virology, School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA. cwood@unl.edu.
authors: Charles
authors: C
authors: Wood
authors: Department of Epidemiology, School of Public Health, Fudan University, and The Key Laboratory of Public Health Safety of Ministry of Education, Shanghai 200032, China. nhe@shmu.edu.cn.
authors: Na
authors: N
authors: He
mesh_terms: D000328:Adult; D000368:Aged; D002681:China / Q000453:epidemiology; D060085:Coinfection; D003430:Cross-Sectional Studies; D055030:Drug Users; D005260:Female; D015658:HIV Infections / Q000453:epidemiology; D016174:Hepacivirus / Q000145:classification / Q000302:isolation & purification*; D006526:Hepatitis C / Q000453:epidemiology*; D006566:Herpesviridae Infections / Q000453:epidemiology*; D019288:Herpesvirus 8, Human / Q000145:classification / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D012703:Serotyping; D013587:Syphilis / Q000453:epidemiology; D055815:Young Adult