title: [Metabolic syndrome and cardiovascular risk patients under antiretrovirals in a day hospital at Bobo-Dioulasso (Burkina Faso)].
abstract: Highly active antiretroviral therapy (HAART) has reduced morbidity and mortality of HIV but has led to an increasing metabolic cardiovascular risk. A cross-sectional study was conducted from May to September 2011 in Day Care Hospital for HIV-Patients of Bobo-Dioulasso. We included in this study 400 patients infected by HIVon antiretroviral therapy ≥ 6 months selected by a random draw. Metabolic syndrome was assessed according to the definitions of the IDF and ATP-III. The high risk of cardiovascular disease in 10 years was defined by a Framingham score ≥ 20%. The average age of our patients was 41.4 years [20-76]. 17% received an IP. The average duration of PI exposure was 35.5 months and 50.1 months for NNRTI. The prevalence of diabetes was 1.3% (95% CI: 0.5-3) and that of hypertension of 12.0 % (95% CI: 9.3-16). The prevalence of metabolic syndrome according to IDF was 10% (95% CI: 7.3-13.5) and the metabolic syndrome according to ATP-III 12.3% (95% CI: 9.3-16). The body mass index was higher (BMI 25.2 vs. 22.5 kg/m(2), p <10(-3) with ATPIII and BMI 26.6 vs. 22.4 kg/m(2), p <10(-3) with IDF), and duration exposure to ARVs longer in patients with metabolic syndrome regardless of the definition used (58.6 months vs 27.9 months). High cardiovascular risk was present in 1.8% (95% CI: 0.8 to 3.7) of our patients, all male more than half (n=4/7) of them were smoking. The choice of antiretroviral therapy must take into account its potential long-term toxicity. It should also strengthen supervision.
authors: Service d'hépato-gastro-entérologie du CHU Sanou Sourô (CHUSS), 01 BP 676, Bobo-Dioulasso 01, Burkina Faso, drsawadogo.appolinaire@yahoo.fr.
authors: A
authors: A
authors: Sawadogo
authors: S
authors: S
authors: Sanou
authors: A
authors: A
authors: Hema
authors: B E
authors: BE
authors: Kamboule
authors: N F
authors: NF
authors: Kabore
authors: I
authors: I
authors: Sore
authors: A
authors: A
authors: Konate
authors: G E A
authors: GE
authors: Poda
authors: J
authors: J
authors: Zoungrana
authors: A B
authors: AB
authors: Sawadogo
mesh_terms: D000328:Adult; D000368:Aged; D000554:Ambulatory Care Facilities; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects; D002050:Burkina Faso / Q000453:epidemiology; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology*; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000453:epidemiology; D015497:HIV-1; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000209:etiology*; D008875:Middle Aged; D012307:Risk Factors; D055815:Young Adult