title: Psychiatric disturbances in patients with progressive supranuclear palsy: a case-control study.
abstract: OBJECTIVE
  To investigate the frequency and the different types of psychiatric disturbances in PSP patients using validated psychiatric instruments.
  
  
  METHODS
  We conducted a case-control study using the Structured Clinical Interview (SCID-I) for DSM-IV to investigate psychiatric disorders in 28 PSP patients and 28 age and gender matched healthy controls. PSP severity was scored using the PSP rating scale; cognitive functions were assessed using the Montreal Cognitive Assessment scale and the Frontal Assessment Battery scale.
  
  
  RESULTS
  SCID-I disclosed that psychiatric disturbances were more frequent in PSP patients (53%) than in healthy controls (17.8%) (p = 0.005). Psychiatric disorders in PSP patients were characterized by mood disorders. Depression due to PSP was the most frequent diagnosis and was found in 8 of the 15 patients with depressive disorders. None of the PSP patients had a diagnosis of other SCID-I disorders. No clinical or demographic differences were found when comparing PSP patients with and without psychiatric disturbances.
  
  
  CONCLUSIONS
  Psychiatric disturbances, namely depressive disorders, were more frequent in PSP patients than in controls. A thorough evaluation of psychiatric disorders is important to insure appropriate treatment of PSP patients..
authors: Department of Neurology and Psychiatry, Sapienza University of Rome, Italy.
authors: Maria Carmela
authors: MC
authors: Bloise
authors: Department of Neurology and Psychiatry, Sapienza University of Rome, Italy.
authors: Isabella
authors: I
authors: Berardelli
authors: Department of Neurology and Psychiatry, Sapienza University of Rome, Italy.
authors: Valentina
authors: V
authors: Roselli
authors: Department of Neurology and Psychiatry, Sapienza University of Rome, Italy.
authors: Massimo
authors: M
authors: Pasquini
authors: Department of Neurology and Psychiatry, Sapienza University of Rome, Italy.
authors: Paola
authors: P
authors: Stirpe
authors: Department of Neurology and Psychiatry, Sapienza University of Rome, Italy.
authors: Carlo
authors: C
authors: Colosimo
authors: Department of Neurology and Psychiatry, Sapienza University of Rome, Italy; IRCSS Neuromed Institute, Pozzilli, IS, Italy.
authors: Alfredo
authors: A
authors: Berardelli
authors: Department of Neurology and Psychiatry, Sapienza University of Rome, Italy; IRCSS Neuromed Institute, Pozzilli, IS, Italy. Electronic address: giovanni.fabbrini@uniroma1.it.
authors: Giovanni
authors: G
authors: Fabbrini
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001519:Behavior / Q000502:physiology; D016022:Case-Control Studies; D003071:Cognition / Q000502:physiology*; D003866:Depressive Disorder / Q000209:etiology / Q000523:psychology / Q000628:therapy*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013494:Supranuclear Palsy, Progressive / Q000150:complications / Q000523:psychology / Q000628:therapy*
keywords: Anxiety; Depression; Progressive supranuclear palsy; SCID-I