title: Insulin resistance in patients with post-adolescent acne.
abstract: BACKGROUND
  Post-adolescent acne has been defined as acne in a patient aged >25 years. Acne vulgaris first develops at the onset of puberty as a result of hormonal changes. During puberty, there is a transient decline in insulin sensitivity. We hypothesized that insulin resistance might persist after puberty in patients with post-adolescent acne.
  
  
  OBJECTIVE
  This study was conducted in order to investigate the relationship between post-adolescent acne and insulin resistance.
  
  
  METHODS
  The study population comprised 35 patients with post-adolescent acne and 35 healthy control subjects. The parameters measured were fasting blood glucose, insulin, aspartate aminotransferase (AST) and alanine aminotransferase (ALT), total cholesterol (TC), triglycerides, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). The homeostasis model assessment of insulin resistance (HOMA-IR) index was calculated for each individual.
  
  
  RESULTS
  No significant differences were observed between patients with post-adolescent acne and control subjects in fasting blood glucose, fasting insulin, AST, ALT, triglyceride and HDL-C levels, and HOMA-IR index. There were also no correlations between these parameters and the severity of acne.
  
  
  CONCLUSIONS
  This study suggests that insulin resistance may not play a major role in the pathogenesis of post-adolescent acne. Hormonal changes, genetic susceptibility, stress, the use of cosmetics, drugs, and environmental factors should be considered in the development of post-adolescent acne.
authors: Department of Dermatology, Kecioren Training and Research Hospital, Ministry of Health, Ankara, Turkey.
authors: Ilknur
authors: I
authors: Balta
authors: Department of Dermatology, Tayfur Ata Sokmen School of Medicine, Mustafa Kemal University, Hatay, Turkey.
authors: Ozlem
authors: O
authors: Ekiz
authors: Department of Dermatology, School of Medicine, Afyon Kocatepe University, Afyon, Turkey.
authors: Pınar
authors: P
authors: Ozuguz
authors: Department of Endocrinology, Tayfur Ata Sokmen School of Medicine, Mustafa Kemal University, Hatay, Turkey.
authors: Ihsan
authors: I
authors: Ustun
authors: Department of Dermatology, School of Medicine, Afyon Kocatepe University, Afyon, Turkey.
authors: Semsettin
authors: S
authors: Karaca
authors: Department of Dermatology, School of Medicine, Afyon Kocatepe University, Afyon, Turkey.
authors: Seval
authors: S
authors: Dogruk Kacar
authors: Ankara Training and Research Hospital, Ministry of Health, Department of Dermatology, Ankara, Turkey.
authors: Meral
authors: M
authors: Eksioglu
mesh_terms: D000152:Acne Vulgaris / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged