title: Synchronous pleural and peritoneal malignant mesothelioma: a case report and review of literature.
abstract: The coexistence of mesothelioma and other primary malignancies has been previously reported in literature, but the finding of a pleural mesothelioma with a synchronous peritoneal mesothelioma has not been reported so far. We report a case of a 58-years-old woman that came to our attention for the incidental finding of an inguinal mass. Fine-needle biopsies of the mass and a thoracoscopy with pleural biopsies were performed, after imaging studies showed pleural thickenings suspicious for malignancy. Histological morphology and growth pattern were similar in both cases. Both tumors stained for calretinin, but only the pleural mesothelioma showed positivity for Wilms-Tumor 1 antibody. We tried to demonstrate with molecular biology techniques whether they were synchronous or one was the metastasis of the other, but our studies did not give informative results. The prognosis in this case is poor, and after 6 months the patient is still following a chemotherapy regimen, which is the only practicable approach given the extent of the disease.
authors: Division of Pathology, Fondazione IRCCS "Ca' Granda" - Ospedale Maggiore Policlinico and University of Milan Medical School Italy.
authors: Alessandro
authors: A
authors: Del Gobbo
authors: Division of Pathology, Fondazione IRCCS "Ca' Granda" - Ospedale Maggiore Policlinico and University of Milan Medical School Italy.
authors: Stefano
authors: S
authors: Fiori
authors: Division of Pathology, Fondazione IRCCS "Ca' Granda" - Ospedale Maggiore Policlinico and University of Milan Medical School Italy.
authors: Gabriella
authors: G
authors: Gaudioso
authors: Division of Pathology, Fondazione IRCCS "Ca' Granda" - Ospedale Maggiore Policlinico and University of Milan Medical School Italy.
authors: Eleonora
authors: E
authors: Bonaparte
authors: Department of Clinical/Surgical Pathophysiology and Organ Transplant, University of Milan Medical School and Division of Pathology, Fondazione IRCCS "Ca' Granda" - Ospedale Maggiore Policlinico Italy.
authors: Silvia
authors: S
authors: Tabano
authors: Division of Thoracic Surgery, Fondazione IRCCS "Ca' Granda" Ospedale Maggiore Policlinico Milan, Italy.
authors: Alessandro
authors: A
authors: Palleschi
authors: Department of Clinical/Surgical Pathophysiology and Organ Transplant, University of Milan Medical School and Division of Pathology, Fondazione IRCCS "Ca' Granda" - Ospedale Maggiore Policlinico Italy.
authors: Silvano
authors: S
authors: Bosari
authors: Department of Biomedical, Surgical and Dental Sciences, University of Milan Medical School and Division of Pathology, Fondazione IRCCS "Ca' Granda" - Ospedale Maggiore Policlinico Italy.
authors: Stefano
authors: S
authors: Ferrero
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics; D044963:Biopsy, Fine-Needle; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000737:chemistry / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D008297:Male; D008654:Mesothelioma / Q000737:chemistry / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D000086002:Mesothelioma, Malignant; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D010534:Peritoneal Neoplasms / Q000737:chemistry / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D010997:Pleural Neoplasms / Q000737:chemistry / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D011237:Predictive Value of Tests; D013906:Thoracoscopy; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor
keywords: EGFR; Mesothelioma; X-chromosome inactivation; peritoneal malignancy; pleural malignancy