title: Hypothalamic inflammation and the central nervous system control of energy homeostasis.
abstract: The control of energy homeostasis relies on robust neuronal circuits that regulate food intake and energy expenditure. Although the physiology of these circuits is well understood, the molecular and cellular response of this program to chronic diseases is still largely unclear. Hypothalamic inflammation has emerged as a major driver of energy homeostasis dysfunction in both obesity and anorexia. Importantly, this inflammation disrupts the action of metabolic signals promoting anabolism or supporting catabolism. In this review, we address the evidence that favors hypothalamic inflammation as a factor that resets energy homeostasis in pathological states.
authors: Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
authors: Gustavo D
authors: GD
authors: Pimentel
authors: Cardiovascular Research Institute, University of California, San Francisco, CA 94158-9001, United States.
authors: Kirthana
authors: K
authors: Ganeshan
authors: Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil. Electronic address: carvalheira@me.com.
authors: José B C
authors: JB
authors: Carvalheira
mesh_terms: D000818:Animals; D000855:Anorexia / Q000150:complications / Q000378:metabolism / Q000473:pathology; D002490:Central Nervous System / Q000502:physiology*; D004734:Energy Metabolism; D006706:Homeostasis; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism / Q000473:pathology*; D007249:Inflammation / Q000150:complications; D007328:Insulin / Q000378:metabolism; D020738:Leptin / Q000378:metabolism; D008954:Models, Biological; D009765:Obesity / Q000150:complications / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction
chemical_list: D007328:Insulin; D020738:Leptin
keywords: Cancer; Cytokines; Hypothalamus; Inflammation; Obesity; Peripheral tissues