title: Insulin secreting and alpha-glucosidase inhibitory activity of hexane extract of Annona squamosa Linn. in streptozotocin (STZ) induced diabetic rats.
abstract: The hexane extract of A. squamosa (ASHE) in 100 and 400 mg/kg body weight dose raised the insulin level when compared with Glimepiride (1 mg/kg) and also inhibited alpha-glucosidase activity when compared with Acarbose (10 mg/kg) in streptozotocin induced diabetic rats. The ASHE significantly reduced peak blood glucose (Gp30) and area under curve (AUC) in diabetic rats in oral glucose (OGTT) and oral sucrose (OSTT) tolerance test, but there was more reduction of Gp30 value than AUC in OSTT. Thus, it can be suggested that the ASHE, has hypoglycemic role at 2 levels, i.e. it acts as secretagogue and also inhibits the intestinal enzymes, responsible for glucose metabolism.
authors: Ranjana
authors: Yamini B
authors: YB
authors: Tripathi
mesh_terms: D000818:Animals; D031041:Annona / Q000737:chemistry; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism*; D065089:Glycoside Hydrolase Inhibitors; D006586:Hexanes / Q000737:chemistry; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000627:therapeutic use*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*; D051381:Rats
chemical_list: D065089:Glycoside Hydrolase Inhibitors; D006586:Hexanes; D007004:Hypoglycemic Agents; D007328:Insulin; D010936:Plant Extracts