title: High-oleic peanuts: new perspective to attenuate glucose homeostasis disruption and inflammation related obesity.
abstract: OBJECTIVE
  To evaluate the effects of acute and daily consumption of high-oleic peanuts (HOP) on inflammation and glucose homeostasis in overweight/obese men.
  
  
  METHODS
  In a 4-week randomized clinical trial, males with body mass index of 29.8 ± 2.3 kg/m(2) and aged 18-50 years were assigned to the groups: control (CT, n = 22); conventional peanuts (CVP, n = 22); or HOP (n = 21). They followed a hypocaloric-diet with or without 56 g/day of CVP or HOP. Main outcomes were changes in fasting blood biomarkers and postprandial insulin, glucose, tumor necrosis factor-alfa (TNF-α), and interleukin-10 (IL-10) responses after acute peanut intake.
  
  
  RESULTS
  At baseline, HOP showed significantly lower postprandial responses of glucose, insulin, and TNF-α than CVP and CT. Changes in fasting blood biomarkers did not differ between groups after the 4-week intervention. However, within groups, total cholesterol decreased in CT, and all groups reduced High-density lipoprotein (HDL-c). Triglycerides were reduced in HOP and CVP. IL-10 increased significantly in all groups while only the CT and CVP showed increased TNF-α after intervention.
  
  
  CONCLUSIONS
  Acute high-oleic peanut consumption leads to stronger moderation of postprandial glucose, insulin, and TNF-α concentrations than CVP and control meal intake. Whether daily intake of high-oleic peanuts has additional benefits to CVP remains uncertain.
authors: Nutrition and Health Department, Universidade Federal de Viçosa.
authors: Raquel Duarte
authors: RD
authors: Moreira Alves
authors: Ana Paula
authors: AP
authors: Boroni Moreira
authors: Viviane Silva
authors: VS
authors: Macedo
authors: Josefina
authors: J
authors: Bressan
authors: Rita
authors: R
authors: de Cássia Gonçalves Alfenas
authors: Richard
authors: R
authors: Mattes
authors: Neuza Maria
authors: NM
authors: Brunoro Costa
mesh_terms: D000293:Adolescent; D000328:Adult; D010367:Arachis; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D004032:Diet; D005215:Fasting; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000517:prevention & control; D019301:Oleic Acid / Q000494:pharmacology*; D019518:Postprandial Period; D013997:Time Factors; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D019301:Oleic Acid