title: Synthesis and Antimicrobial Activities of His(2-aryl)-Arg and Trp-His(2-aryl) Classes of Dipeptidomimetics.
abstract: In this communication, we report the design, synthesis andin vitroantimicrobial activity of ultra short peptidomimetics. Besides producing promising antibacterial activities againstStaphylococcus aureusand methicillin-resistantS. aureus(MRSA), the dipeptidomimetics exhibited high antifungal activity againstC. neoformanswith IC50values in the range of 0.16-19 μg/mL. The most potent analogs exhibited 4-fold higher activity than the currently used drug amphotericin B, with no apparent cytotoxicity in a panel of mammalian cell lines.
authors: Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, S. A. S. Nagar, Punjab 160 062, India.
authors: Amit
authors: A
authors: Mahindra
authors: Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, S. A. S. Nagar, Punjab 160 062, India.
authors: Krishna K
authors: KK
authors: Sharma
authors: Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, S. A. S. Nagar, Punjab 160 062, India.
authors: Dinesh
authors: D
authors: Rathore
authors: National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA.
authors: Shabana I
authors: SI
authors: Khan
authors: National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA.
authors: Melissa R
authors: MR
authors: Jacob
authors: Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, S. A. S. Nagar, Punjab 160 062, India.
authors: Rahul
authors: R
authors: Jain