title: Effects of resveratrol and other polyphenols in hepatic steatosis.
abstract: Non-alcoholic fatty liver disease covers a wide spectrum of liver pathologies which range from simple steatosis to non-alcoholic steatohepatitis. Polyphenols are members of a very large family of plant-derived compounds that can have beneficial effects on human health, and thus their study has become an increasingly important area of human nutrition research. The aim of the present review is to compile published data concerning the effects of both isolated polyphenols as well as polyphenol extracts, on hepatocyte and liver fat accumulation under different steatosis-inducing conditions. The results reported clearly show that this group of biomolecules is able to reduce fat accumulation, but further studies are needed to establish the optimal dose and treatment period length. With regard to the potential mechanisms of action, there is a good consensus. The anti-lipidogenic effect of polyphenols is mainly due to reduced fatty acid and triacylglycerol synthesis, increased in fatty acid oxidation, and reduced of oxidative stress and inflammation. As a general conclusion, it can be stated that polyphenols are biomolecules which produce hepatoprotective effects. To date, these beneficial effects have been demonstrated in cultured cells and animal models. Thus, studies performed in humans are needed before these molecules can be considered as truly useful tools in the prevention of liver steatosis.
authors: Leixuri Aguirre, Maria Puy Portillo, Nutrition and Obesity Group, Department of Nutrition and Food Science, University of Basque Country (UPV/EHU) and Centro de Investigación Lucio Lascaray, 01006 Vitoria, Spain.
authors: Leixuri
authors: L
authors: Aguirre
authors: Leixuri Aguirre, Maria Puy Portillo, Nutrition and Obesity Group, Department of Nutrition and Food Science, University of Basque Country (UPV/EHU) and Centro de Investigación Lucio Lascaray, 01006 Vitoria, Spain.
authors: Maria Puy
authors: MP
authors: Portillo
authors: Leixuri Aguirre, Maria Puy Portillo, Nutrition and Obesity Group, Department of Nutrition and Food Science, University of Basque Country (UPV/EHU) and Centro de Investigación Lucio Lascaray, 01006 Vitoria, Spain.
authors: Elizabeth
authors: E
authors: Hijona
authors: Leixuri Aguirre, Maria Puy Portillo, Nutrition and Obesity Group, Department of Nutrition and Food Science, University of Basque Country (UPV/EHU) and Centro de Investigación Lucio Lascaray, 01006 Vitoria, Spain.
authors: Luis
authors: L
authors: Bujanda
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D050356:Lipid Metabolism / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D065626:Non-alcoholic Fatty Liver Disease / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D010946:Plants, Medicinal; D059808:Polyphenols / Q000627:therapeutic use*; D011794:Quercetin / Q000627:therapeutic use; D000077185:Resveratrol; D013267:Stilbenes / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D059808:Polyphenols; D013267:Stilbenes; D011794:Quercetin; D000077185:Resveratrol
keywords: Non-alcoholic fatty liver disease; Polyphenols; Quercetin liver; Resveratrol; Steatosis