title: Effects of 60-day head-down bed rest on osteocalcin, glycolipid metabolism and their association with or without resistance training.
abstract: BACKGROUND
  Bone loss and subclinical diabeteslike are developed during long-term spaceflight. Recently, it was demonstrated that bone was able to regulate energy metabolism and testosterone synthesis via osteocalcin. The aim of this study was to determine whether serum osteocalcin level is associated with glycolipid metabolism or testosterone under the influence of microgravity with or without resistive vibration exercise (RVE).
  
  
  METHODS
  A total of 14 healthy adult male volunteers (25-40 years) were randomly assigned to two groups (n = 7 each): control (CON) group and RVE group. Radioimmunoassay kits and ELISA kits were used for measurement of serum indices.
  
  
  RESULTS
  During 60-day bed rest, serum osteocalcin of both groups increased at day 4 during bed rest. Serum OPG started decreasing and reached its lowest value at day 30 during bed rest. In control group, serum insulin increased at day 4 during bed rest. IGF-I did not change significantly during the entire period of bed rest. The serum glucose decline 10% and 14% in CON and RVE groups at day 4 during bed rest. Relatively, the same results as glucose were found in serum HDL and LDL for both groups. Leptin rose and became highest at day 60 during bed rest in both groups. The level of serum testosterone was declined in control group at day 4 during bed rest. Cortisol kept stable in both group during bed rest. By spearman correlation analysis, serum osteocalcin was significantly associated with serum insulin (P < 0·05), LDL (P < 0·01) and Leptin (P < 0·01).
  
  
  CONCLUSIONS
  Our findings suggested that the mutual regulation may exist between skeletal and energy metabolism under simulated microgravity.
authors: School of Life Science and Technology, Haerbin Institute of Technology, Haerbin, China; State key Lab of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China.
authors: Chao
authors: C
authors: Yang
authors: Jian
authors: J
authors: Chen
authors: Feng
authors: F
authors: Wu
authors: Jinqiao
authors: J
authors: Li
authors: Peilong
authors: P
authors: Liang
authors: Hongyu
authors: H
authors: Zhang
authors: Honghui
authors: H
authors: Wang
authors: Yu
authors: Y
authors: Li
authors: Yumin
authors: Y
authors: Wan
authors: Ling
authors: L
authors: Qin
authors: Kwok Sui
authors: KS
authors: Liang
authors: Zhongquan
authors: Z
authors: Dai
authors: Yinghui
authors: Y
authors: Li
mesh_terms: D000328:Adult; D001510:Bed Rest / Q000379:methods*; D001786:Blood Glucose / Q000378:metabolism; D015519:Bone Density; D005081:Exercise Therapy; D006017:Glycolipids / Q000378:metabolism*; D018475:Head-Down Tilt / Q000502:physiology*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D050356:Lipid Metabolism; D008297:Male; D015675:Osteocalcin / Q000097:blood*; D055070:Resistance Training; D013739:Testosterone / Q000097:blood; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D006017:Glycolipids; D015675:Osteocalcin; D013739:Testosterone; D006854:Hydrocortisone