title: Successful pregnancy outcome after in vitro fertilisation following Pre-implantation Genetic Diagnosis/Polymerase Chain Reaction screening for single gene disorder (sickle cell anaemia) before embryo transfer: The clinical experience of an in vitro fertilisation clinic in Nigeria.
abstract: A couple, both carriers of the sickle cell anaemia trait (Genotype HbAS) with an offspring already affected with the genetic disease underwent a Pre-implantation Genetic Diagnosis/Polymerase Chain Reaction screening of biopsied blastomeres. DNA analysis of single blastomeres was carried out to find out indicated a viable intra-uterine pregnancy with embryos which carried the sickle cell mutation, which resulted in a livebirth (HbAS). PGD/PCR in combination with IVF appears to be the most suitable treatment plan for patients who are at a higher risk of reproducing offspring affected with inheritable genetic diseases.
authors: Medical Assisted Reproductive Technology Centre, Ikeja, Lagos, Nigeria.
authors: Chizara
authors: C
authors: Okeke
authors: Medical Assisted Reproductive Technology Centre, Ikeja, Lagos, Nigeria.
authors: Kemi
authors: K
authors: Ailoje-Ibru
authors: Medical Assisted Reproductive Technology Centre, Ikeja, Lagos, Nigeria.
authors: Kemi
authors: K
authors: Olukoya
authors: Medical Assisted Reproductive Technology Centre, Ikeja, Lagos, Nigeria.
authors: Rose
authors: R
authors: Ogbeche
authors: Medical Assisted Reproductive Technology Centre, Ikeja, Lagos, Nigeria.
authors: Abiola
authors: A
authors: Adewusi
authors: Medical Assisted Reproductive Technology Centre, Ikeja, Lagos, Nigeria.
authors: Ebele
authors: E
authors: Iloabachie
authors: Medical Assisted Reproductive Technology Centre, Ikeja, Lagos, Nigeria ; Medical Assisted Reproductive Technology Centre, University of Illinois, Chicago, Illinois, USA.
authors: Oladapo
authors: O
authors: Ashiru
keywords: Biopsy; FET; IVF; PGD/PCR; Sickle cell anaemia