title: Intrapancreatic accessory spleen: possibilities of computed tomography in differentiation from nonfunctioning pancreatic neuroendocrine tumor.
abstract: OBJECTIVE
  The aim of this study was to evaluate the ability of computed tomography (CT) in differentiating between intrapancreatic accessory spleen (IPAS) from pancreatic neuroendocrine tumor (PanNET).
  
  
  METHODS
  Eight IPASs and 12 PanNETs in the pancreatic tail were retrospectively evaluated by 2 radiologists. Readers assigned a diagnosis to each examination and evaluated for the presence or absence of 9 CT findings that may aid in the diagnosis.
  
  
  RESULTS
  Reader 1 had a sensitivity of 0.83 and a specificity of 1; reader 2 had a sensitivity of 0.78 and a specificity of 0.86. Three of the 9 CT findings were found to be statistically significant in IPASs: the lesion present along the pancreatic dorsal surface, the lesion demonstrating the same enhancement as the spleen on venous phase, and heterogeneous enhancement during arterial phase.
  
  
  CONCLUSIONS
  CT can be used to differentiate between IPAS and PanNET with good specificity and sensitivity. The IPAS mirrors the spleen's enhancement and is usually located along the dorsal surface of the pancreas.
authors: From the *Department of Radiology, †Division of Biostatistics and Bioinformatics, Sidney Kimmel Cancer Center, and ‡Department of Pathology, the Sol Goldman Pancreatic Center Research Center, Johns Hopkins Hospital, Baltimore, MD.
authors: Stephanie F
authors: SF
authors: Coquia
authors: Satomi
authors: S
authors: Kawamoto
authors: Atif
authors: A
authors: Zaheer
authors: Karen B
authors: KB
authors: Bleich
authors: Amanda L
authors: AL
authors: Blackford
authors: Ralph H
authors: RH
authors: Hruban
authors: Elliot K
authors: EK
authors: Fishman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002828:Choristoma / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010182:Pancreatic Diseases / Q000000981:diagnostic imaging*; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging*; D012189:Retrospective Studies; D013154:Spleen; D014057:Tomography, X-Ray Computed