title: Brain neuropeptides in gastric mucosal protection.
abstract: The centrally induced gastroprotective effect of neuropeptides has been intensively studied. Besides many similarities, however, differences can also be observed in their gastroprotective actions. The gastroprotective dose-response curve proved to be either sigmoid, or bell-shaped. Additional gastrointestinal effects of neuropeptides can contribute to their mucosal protective effect. Part of the neuropeptides induces gastroprotection by peripheral administration as well. Besides vagal nerve the sympathetic nervous system may also be involved in conveying the central effect to the periphery. Better understanding of the complex mechanism of the maintenance of gastric mucosal integrity may result in the development of new strategy to enhance gastric mucosal resistance against injury.
authors: Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Semmelweis University, Nagyvárad tér 4, 1089, Budapest, Hungary. Electronic address: gyires.klara@med.semmelweis-univ.hu.
authors: Klára
authors: K
authors: Gyires
authors: Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Semmelweis University, Nagyvárad tér 4, 1089, Budapest, Hungary.
authors: Zoltán S
authors: ZS
authors: Zádori
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005753:Gastric Mucosa / Q000187:drug effects*; D009479:Neuropeptides / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology*
chemical_list: D009479:Neuropeptides; D020011:Protective Agents