title: Effects of intranasal oxytocin administration on memory for infant cues: moderation by childhood emotional maltreatment.
abstract: Oxytocin has been implicated in parent-infant attachment and social recognition. With respect to emotion recognition memory, both memory-enhancing and impairing effects have been observed, suggesting an influence of individual factors. We assessed the effects of oxytocin on memory for infant cues, and whether these effects are moderated by self-reported childhood emotional maltreatment. Nulliparous females (N = 102) participated in a randomized, double-blind, between-subjects study with intranasal oxytocin or placebo administration. Participants' memory was tested using the Baby Social Reward Task, where participants were asked to select the happier infant from a pair of two infants based on the information that they received about the infants' mood in the previous phase. Participants reporting more childhood emotional maltreatment were less accurate in this task after inhaling oxytocin. Our findings add to a growing body of literature showing that the effects of intranasal oxytocin on memory and social behavior are moderated by adverse early life experiences.
authors: a Centre for Child and Family Studies , Leiden University , Leiden , Netherlands.
authors: Ritu
authors: R
authors: Bhandari
authors: Rixt
authors: R
authors: van der Veen
authors: Christine E
authors: CE
authors: Parsons
authors: Katherine S
authors: KS
authors: Young
authors: Alexandra
authors: A
authors: Voorthuis
authors: Marian J
authors: MJ
authors: Bakermans-Kranenburg
authors: Alan
authors: A
authors: Stein
authors: Morten L
authors: ML
authors: Kringelbach
authors: Marinus H
authors: MH
authors: van IJzendoorn
mesh_terms: D000281:Administration, Intranasal; D002491:Central Nervous System Agents / Q000008:administration & dosage*; D002649:Child Abuse / Q000523:psychology*; D003463:Cues; D004311:Double-Blind Method; D004644:Emotions; D005149:Facial Expression; D005260:Female; D006801:Humans; D007223:Infant; D007858:Learning / Q000502:physiology; D008568:Memory / Q000502:physiology*; D010121:Oxytocin / Q000008:administration & dosage*; D010364:Pattern Recognition, Visual / Q000502:physiology; D011581:Psychological Tests; D011930:Reaction Time; D012938:Social Perception; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D002491:Central Nervous System Agents; D010121:Oxytocin
keywords: Baby Social Reward Task; Decision-making; Emotional maltreatment; Intranasal administration; Memory; Oxytocin