title: Novel prospective in colon specific drug delivery system.
abstract: This review deals with the targeting of drugs to the lower gastrointestinal tract i.e. colon. Colonic drug delivery becomes important for localized action as well as for improved systemic availability of peptide and proteins. Drugs which have absorption window in the colonic region have been targeted using different novel technologies. pH sensitive polymers and prodrug based formulation have been used for the delivery of drugs into the colon. Different natural polymers have been used successfully for the delivery of drugs into the colon. Natural polymers are less toxic, biodegradable and easily available with a wide range of molecular weight and varying chemical compositions. One of the supporting properties associated with these polymers is that natural polymers can be used as approved pharmaceutical excipient.
authors: Research Associate, FR&D, Akums Drugs and Pharmaceuticals Ltd, Haridwar, UK, India.
authors: Vipin
authors: V
authors: Bansal
authors: Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India.
authors: Rishabha
authors: R
authors: Malviya
authors: Department of Botany, University of Allahabad, Allahabad, Uttar Pradesh, India.
authors: Tanya
authors: T
authors: Malaviya
authors: Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India.
authors: Pramod Kumar
authors: PK
authors: Sharma
mesh_terms: D020341:Absorbable Implants; D000284:Administration, Oral; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D020099:Coated Materials, Biocompatible; D003106:Colon / Q000378:metabolism*; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D005079:Excipients / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D006863:Hydrogen-Ion Concentration; D008970:Molecular Weight; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D011134:Polysaccharides / Q000737:chemistry*; D011355:Prodrugs / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D020551:Pulse Therapy, Drug
chemical_list: D020099:Coated Materials, Biocompatible; D004337:Drug Carriers; D005079:Excipients; D004364:Pharmaceutical Preparations; D011134:Polysaccharides; D011355:Prodrugs