title: The odontogenic-related microinflammation in patients with chronic kidney disease.
abstract: OBJECTIVE
  This study estimated plasma levels of interleukin IL-1β, IL-6, tumour necrosis factor-α (TNF-α), interferon-γ (INF-γ) in chronic kidney disease (CKD) patients with a single odontogenic pathology.
  
  
  METHODS
  Forty-nine selected adult CKD patients with single odontogenic pathology based on clinical and X-ray examination: patients after proper root canal treatment, without periapical lesions (n = 12), with pulp necrosis (n = 7), with asymptomatic periapical lesions (n = 22), with periodontal disease (n = 8), and 14 with healthy teeth were enrolled. Patients with coexisting different dental pathologies and the evidence of other infection were excluded. In all patients plasma concentrations of CRP, IL-1β, IL-6, TNF-α, and INF-γ were measured.
  
  
  RESULTS
  Patients with periodontitis were characterized by increased concentrations of IL-6 and TNF-α. Those with pulp necrosis had significantly more frequently serum CRP level over 2 mg/L and presented significantly elevated IL-6, but decreased TNF-α concentration than in the subjects with healthy teeth. In patients with periapical lesions and patients after root canal therapy, the concentrations of cytokines did not indicate for the systemic inflammation.
  
  
  CONCLUSIONS
  Periodontitis and pulp necrosis are important sources of systemic microinflammation in CKD patients. Plasma concentrations of IL-6 and TNF-α appear to be more sensitive markers of odontogenic inflammation in CKD patients than CRP.
authors: Department of Craniomaxillofacial Surgery, Medical University of Silesia , Katowice , Poland .
authors: Iwona
authors: I
authors: Niedzielska
authors: Jerzy
authors: J
authors: Chudek
authors: Izabela
authors: I
authors: Kowol
authors: Natalia
authors: N
authors: Slabiak-Blaz
authors: Aureliusz
authors: A
authors: Kolonko
authors: Piotr
authors: P
authors: Kuczera
authors: Andrzej
authors: A
authors: Wiecek
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D003788:Dental Pulp Diseases / Q000097:blood / Q000150:complications* / Q000382:microbiology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D008297:Male; D008875:Middle Aged; D010483:Periapical Diseases / Q000097:blood / Q000150:complications* / Q000382:microbiology; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000150:complications*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D016207:Cytokines; D002097:C-Reactive Protein
keywords: Chronic kidney disease; IL-6; TNF-alpha; odontogenic inflammation