title: [Clinical aspects of 41 cases performed challenge test with immediate-type wheat allergy due to hydrolyzed wheat protein (HWP-IWA)].
abstract: BACKGROUND
  Immediate-type wheat allergy due to hydrolyzed wheat protein (HWP-IWA) supplemented soap has been a serious social issue. We investigated the significance of challenge test and other tests not only to diagnose HWP-IWA but to know the symptoms of each patients.
  
  
  METHODS
  From January 2010 to June 2012, we performed challenge test in 41 cases with positive prick test of Glupearl 19S®, a major allergic HWP found in Cha no Shizuku®.
  
  
  RESULTS
  Thirty nine of 41 cases were challenge test positive. In two patients who showed positive skin prick test but negative for challenge test, titer of specific IgE antibody and/or basophil histamine release test against Glupearl 19S® revealed positive reaction.
  
  
  CONCLUSIONS
  Challenge test is not included in indispensable examinations for the diagnosis of HWP-IWA in the recommended guidelines. However, challenge test is still a useful tool for assessing actual severity of each patient's symptoms and determining the timing of cessation of wheat avoidance. In addition, combined check-up with several laboratory examination and challenge test may help appropriate diagnosis of HWP-IWA.
authors: Clinical Research Center, National Fukuoka Hospital.
authors: Akiko
authors: A
authors: Sugiyama
authors: Clinical Research Center, National Fukuoka Hospital.
authors: Reiko
authors: R
authors: Kishikawa
authors: Clinical Research Center, National Fukuoka Hospital.
authors: Terufumi
authors: T
authors: Shimoda
authors: Clinical Research Center, National Fukuoka Hospital.
authors: Haruko
authors: H
authors: Nishie
authors: Clinical Research Center, National Fukuoka Hospital.
authors: Kiyotaka
authors: K
authors: Shimada
authors: Clinical Research Center, National Fukuoka Hospital.
authors: Tomoaki
authors: T
authors: Iwanaga
authors: The Department of Dermatology, Graduate School of Medical Sciences, Kyushu University.
authors: Masutaka
authors: M
authors: Furue
authors: Clinical Research Center, National Fukuoka Hospital.
authors: Sankei
authors: S
authors: Nishima
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D006801:Humans; D006868:Hydrolysis; D008297:Male; D008875:Middle Aged; D010940:Plant Proteins / Q000276:immunology*; D012915:Soaps / Q000009:adverse effects; D014908:Triticum / Q000276:immunology*; D021182:Wheat Hypersensitivity / Q000175:diagnosis / Q000276:immunology*
chemical_list: D010940:Plant Proteins; D012915:Soaps