title: Stem cells, immortalized cells and primary cells in ADMET assays.
abstract: Cell-based assays are beginning to replace traditional absorption, distribution, metabolism, elimination and toxicology (ADMET) models employing subcellular fractions in high throughput drug discovery screening and drug development where drugs are characterized and predictions are formulated to forecast in vivo biological outcomes. Significant and continuing advances in stem cell research, new immortalized cell lines and our enhanced ability to predict outcomes from primary cells have increased the ability to employ cell-based assays to study ADMET properties of new drugs.:
authors: Department of Metabolism and Pharmacokinetics, Pharmaceutical Candidate Optimization, Bristol Myers Squibb Co., 5 Research Parkway, Wallingford, CT 06492, USA. Electronic address:michael.sinz@bms.com.
authors: Michael W
authors: MW
authors: Sinz
authors: Department of Metabolism and Pharmacokinetics, Pharmaceutical Candidate Optimization, Bristol Myers Squibb Co., 5 Research Parkway, Wallingford, CT 06492, USA.
authors: Sean
authors: S
authors: Kim