title: Alterations in microRNA expression profile in rabies virus-infected mouse neurons.
abstract: Rabies virus (RABV) is known to cause a fatal infection in many mammalian species, yet its pathogenesis remains poorly understood. This study was performed to analyze the microRNA (miRNA) expression profiles in RABV-infected primary neurons of mice. A total of 53 miRNAs were found to be differentially expressed in RABV-infected samples compared with mock samples in a time-dependent manner. Among them, the expression of ten miRNAs was validated by real-time RT-PCR. Potential target genes of differentially expressed miRNAs were predicted by TargetScan. Further bioinformatics analysis indicated that these predicted targets were overrepresented in neuronal function-related Gene Ontology (GO) terms and biological pathways. The results of this study suggest that RABV may cause neuronal dysfunction by regulating cellular miRNA expression.
authors: N
authors: N
authors: Shi
authors: X Y
authors: XY
authors: Zhang
authors: C Y
authors: CY
authors: Dong
authors: J L
authors: JL
authors: Hou
authors: M L
authors: ML
authors: Zhang
authors: Z H
authors: ZH
authors: Guan
authors: Z Y
authors: ZY
authors: Li
authors: M
authors: M
authors: Duan
mesh_terms: D000818:Animals; D020869:Gene Expression Profiling; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D011818:Rabies / Q000235:genetics* / Q000378:metabolism / Q000821:virology; D011820:Rabies virus / Q000502:physiology*
chemical_list: D035683:MicroRNAs