title: Executive function and depressive symptoms of retardation in nonelderly stroke patients.
abstract: The depression-executive dysfunction syndrome, a late-onset depression of vascular origin with executive dysfunction and psychomotor retardation, has also been described after stroke. We verified whether this syndrome also occurs in nonelderly stroke patients by investigating the association between domains of depressive symptoms with executive functions in 87 first-ever ischemic stroke patients. The retardation domain of the 31-item Hamilton Rating Scale for Depression was associated with decreased performance on verbal fluency (assessed with FAS). The association was maintained for younger patients (aged <60 years) after adjusting for confounders. This result supports the clinical presentation of depression-executive dysfunction syndrome in younger stroke patients. Confirmation of this finding, its neural correlates, and clinical implication deserve further investigation.
authors: a Consultation-Liaison Psychiatry Group, Department and Institute of Psychiatry, Clinics Hospital , University of São Paulo School of Medicine , São Paulo , Brazil.
authors: Matildes F M
authors: MF
authors: Sobreiro
authors: Eliane Correa
authors: EC
authors: Miotto
authors: Luisa
authors: L
authors: Terroni
authors: Gisela
authors: G
authors: Tinone
authors: Dan V
authors: DV
authors: Iosifescu
authors: Mara C S
authors: MC
authors: de Lucia
authors: Milberto
authors: M
authors: Scaff
authors: Claudia da Costa
authors: Cda C
authors: Leite
authors: Edson
authors: E
authors: Amaro
authors: Renerio
authors: R
authors: Fraguas
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000473:pathology; D003072:Cognition Disorders / Q000209:etiology*; D003866:Depressive Disorder / Q000209:etiology*; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D020521:Stroke / Q000150:complications*; D014706:Verbal Learning; D055815:Young Adult
keywords: Depressive symptoms; Executive functions; Neuropsychological tests; Stroke; Vascular depression