title: Association of apolipoprotein E-219T>G promoter polymorphism with primary open angle glaucoma in Turkish population.
abstract: OBJECTIVE
  To investigate the association between apolipoprotein E (APOE) -219 T>G promoter polymorphism and primary open angle glaucoma (POAG).
  
  
  METHODS
  Patients and healthy subjects were genotyped with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Genotype/allele frequencies were compared between 122 healthy subjects and in 75 POAG patients using Chi-square test.
  
  
  RESULTS
  Although the frequency of APOE -219 GG genotype was higher in POAG group (13.3%) than in control group (6.6%), this finding was not statistically significant (P=0.09). In glaucoma patients carrying GG genotype, mean linear C/D ratio was higher and progression was more compared to glaucoma patients with GT genotype.
  
  
  CONCLUSIONS
  APOE -219 T>G polymorphism does not seem to be a risk factor for the presence of glaucoma, but might play a role in deterioration of the disease, which needs further evaluation.
authors: Department of Molecular Biology, Faculty of Science, Hacettepe University, Ankara 06800, Turkey.
authors: Emel
authors: E
authors: Saglar
authors: Department of Ophthalmology, Selcuk University Faculty of Medicine, Konya 42131, Turkey.
authors: Banu
authors: B
authors: Bozkurt
authors: Department of Ophthalmology, Hacettepe University Faculty of Medicine, Ankara 06100, Turkey.
authors: Murat
authors: M
authors: Irkec
keywords: apolipoprotein E; primary open angle glaucoma; promoter; single nucleotide polymorphism