title: Macrophages in renal transplantation: Roles and therapeutic implications.
abstract: The presence of macrophages within transplanted renal allografts has been appreciated for some time, whereby macrophages were viewed primarily as participants in the process of cell-mediated allograft rejection. Recent insights into macrophage biology have greatly expanded our conceptual understanding of the multiple roles of macrophages within the allograft. Distinct macrophage subsets are present within the kidney and these sub-serve discrete functions in promoting and attenuating inflammation, immune modulation and tissue repair. Unraveling the complex roles macrophages play in transplantation will allow identification of potential therapeutic targets to prevent and treat allograft rejection and maximize graft longevity.
authors: Department of Renal Medicine, Royal Prince Alfred Hospital, Sydney, Australia; Collaborative Transplant Research Group, Sydney Medical School, The University of Sydney, Sydney, Australia.
authors: Tony
authors: T
authors: Kwan
authors: Department of Renal Medicine, Royal Prince Alfred Hospital, Sydney, Australia; Collaborative Transplant Research Group, Sydney Medical School, The University of Sydney, Sydney, Australia.
authors: Huiling
authors: H
authors: Wu
authors: Department of Renal Medicine, Royal Prince Alfred Hospital, Sydney, Australia; Collaborative Transplant Research Group, Sydney Medical School, The University of Sydney, Sydney, Australia. Electronic address: steve.chadban@sswahs.nsw.gov.au.
authors: Steven J
authors: SJ
authors: Chadban
mesh_terms: D000818:Animals; D006084:Graft Rejection / Q000276:immunology*; D006801:Humans; D056747:Immunomodulation / Q000276:immunology; D007249:Inflammation / Q000276:immunology*; D007668:Kidney / Q000276:immunology*; D016030:Kidney Transplantation / Q000379:methods*; D051379:Mice; D009000:Monocytes / Q000276:immunology*; D015427:Reperfusion Injury / Q000276:immunology*
keywords: Innate immunity; Macrophages; Renal transplantation