title: [(18) F]CuCF3 : a [(18) F]trifluoromethylating agent for arylboronic acids and aryl iodides.
abstract: Positron emission tomography has emerged as the leading method for medical imaging with fluorine-18 as the most widely used radioactive isotope. Here we report a semi-automated method for the preparation of valuable [(18) F]trifluoromethylcopper, as well as its use for the radiosynthesis of [(18) F]trifluoromethylarenes and heteroarenes. Mild conditions of [(18) F]trifluoromethylation make this method particularly useful for the radiosynthesis of pharmacologically relevant [(18) F]trifluoromethylarenes and heteroarenes.
authors: Normandie Univ., COBRA, UMR 6014 et FR 3038, Univ. Rouen; INSA Rouen; CNRS, 1 rue Tesnière, 76821 Mont Saint-Aignan Cedex (France).
authors: Pavel
authors: P
authors: Ivashkin
authors: Gérald
authors: G
authors: Lemonnier
authors: Jonathan
authors: J
authors: Cousin
authors: Vincent
authors: V
authors: Grégoire
authors: Daniel
authors: D
authors: Labar
authors: Philippe
authors: P
authors: Jubault
authors: Xavier
authors: X
authors: Pannecoucke
mesh_terms: D000477:Alkylating Agents / Q000737:chemistry; D001897:Boronic Acids / Q000138:chemical synthesis*; D005617:Chlorofluorocarbons, Methane / Q000737:chemistry; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D006847:Hydrocarbons, Iodinated / Q000138:chemical synthesis* / Q000737:chemistry; D007553:Isotope Labeling / Q000379:methods; D008745:Methylation; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis*; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
chemical_list: D000477:Alkylating Agents; D001897:Boronic Acids; D005617:Chlorofluorocarbons, Methane; D005462:Fluorine Radioisotopes; D006847:Hydrocarbons, Iodinated; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; D003300:Copper; C009554:fluoroform
keywords: arylboronic acid; copper; fluorine; radiochemistry; trifluoromethylation