title: Emergency reversal of anticoagulation: novel agents.
abstract: Historically, oral anticoagulation involved the administration of vitamin K antagonists, such as warfarin. However, because of the need for frequent monitoring and the desire for safer anticoagulants, several novel oral anticoagulants have been developed. These newer agents include the factor Xa inhibitors (eg, rivaroxaban, apixaban, edoxaban), along with the direct thrombin inhibitors (eg, dabigatran). This manuscript provides a brief overview of their uses and mechanisms of action, along with a review of currently available evidence for reversal strategies when life-threatening bleeding occurs.
authors: Department of Emergency Medicine, Section of Medical Toxicology, University of Southern California, 1200 North State Street, Room 1011, Los Angeles, CA, 90033, USA, mdlevine@usc.edu.
authors: Michael
authors: M
authors: Levine
authors: Joshua N
authors: JN
authors: Goldstein
mesh_terms: D000925:Anticoagulants / Q000494:pharmacology*; D000991:Antithrombins / Q000494:pharmacology*; D065427:Factor Xa Inhibitors / Q000494:pharmacology*; D006801:Humans
chemical_list: D000925:Anticoagulants; D000991:Antithrombins; D065427:Factor Xa Inhibitors