title: Angiographic evaluation of the effects of glucose metabolic status on progression of coronary artery lesions in patients with coronary artery disease.
abstract: BACKGROUND
  The aim of the present study was to assess the effect of glucose metabolic status on the progression of coronary artery lesions in patients with coronary artery disease (CAD).
  
  
  METHODS
  Two hundred and ninety-eight CAD patients who underwent coronary angiography were included in the study; follow-up angiography was performed after 9-15 months. The Gensini score, SYNTAX score, and the number of diseased vessels (at baseline and follow-up, as well as the change from baseline to follow-up) were used to determine the severity and progression of coronary artery lesions. The relationship between glucose metabolic status and progression of coronary artery lesions was investigated. Based on results of an oral glucose tolerance test, patients were divided into three groups: normal glucose tolerance (NGT); impaired glucose regulation(IGR); and type 2 diabetes mellitus (DM).
  
  
  RESULTS
  Compared with the NGT group, changes (from baseline to follow-up) in the Gensini score, SYNTAX score, and the number of diseased vessels were significantly higher in the IGR and DM groups. There were no significant differences between the IGR and DM groups. Multivariate regression analysis suggested abnormal glucose metabolism was an independent risk factor for greater changes in the Gensini and SYNTAX scores, as well as for a greater number of diseased vessels.
  
  
  CONCLUSIONS
  Greater progression of coronary artery lesions is seen in patients with abnormal glucose metabolism (DM and/or IGR), even when levels of HbA1c are on target.
authors: Department of Endocrinology, East Hospital, Tongji University School of Medicine, Shanghai, China.
authors: Hua
authors: H
authors: Wang
authors: Zhaosheng
authors: Z
authors: Tang
authors: Xu
authors: X
authors: Li
authors: Bo
authors: B
authors: Hu
authors: Bo
authors: B
authors: Feng
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging*; D003331:Coronary Vessels; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications*; D018450:Disease Progression; D005260:Female; D018149:Glucose Intolerance / Q000097:blood / Q000150:complications*; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D001786:Blood Glucose
keywords: abnormal glucose metabolism; angiography; coronary artery lesions; 关键词：糖代谢异常，血管造影，冠状动脉病变