title: Tertiary amide-based Knoevenagel-type reactions: a direct, general, and chemoselective approach to enaminones.
abstract: We report one-pot and chemoselective Knoevenagel-type reactions using highly stable amides and lactams as the electrophilic substrates. The method is based on the in situ activation of amide carbonyl with triflic anhydride and a subsequent reaction with carbanions generated in situ from carbonyl compounds. The amide-based method is an alternative to the versatile thioamide-based Eschenmoser sulfide contraction.
authors: Department of Chemistry, College of Chemistry and Chemical Engineering, and Fujian Provincial Key Laboratory of Chemical Biology, Xiamen University, Xiamen, Fujian 361005, P. R. China. pqhuang@xmu.edu.cn.
authors: Pei-Qiang
authors: PQ
authors: Huang
authors: Wei
authors: W
authors: Ou
authors: Kai-Jiong
authors: KJ
authors: Xiao
authors: Ai-E
authors: AE
authors: Wang