title: Eurothiocin A and B, sulfur-containing benzofurans from a soft coral-derived fungus Eurotium rubrum SH-823.
abstract: Two new sulfur-containing benzofuran derivatives, eurothiocin A and B (1 and 2), along with five known compounds, zinniol (3), butyrolactone I (4), aspernolide D (5), vermistatin (6), and methoxyvermistatin (7), were isolated from the cultures of Eurotium rubrum SH-823, a fungus obtained from a Sarcophyton sp. soft coral collected from the South China Sea. The new compounds (1 and 2) share a methyl thiolester moiety, which is quite rare among natural secondary metabolites. The structures of these metabolites were assigned on the basis of detailed spectroscopic analysis. The absolute configurations of 1 and 2 were determined by comparison of the experimental and calculated electronic circular dichroism (ECD) data. Compounds 1 and 2 exhibited more potent inhibitory effects against α-glucosidase activity than the clinical α-glucosidase inhibitor acarbose. Further mechanistic analysis showed that both of them exhibited competitive inhibition characteristics.
authors: School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China. liuzhaom@mail2.sysu.edu.cn.
authors: Zhaoming
authors: Z
authors: Liu
authors: School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China. xiagp@mail2.sysu.edu.cn.
authors: Guoping
authors: G
authors: Xia
authors: School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China. chensh65@mail2.sysu.edu.cn.
authors: Senhua
authors: S
authors: Chen
authors: School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China. liuyayue@mail2.sysu.edu.cn.
authors: Yayue
authors: Y
authors: Liu
authors: School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China. lihx3@mail.sysu.edu.cn.
authors: Hanxiang
authors: H
authors: Li
authors: School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China. cesshzhg@mail.sysu.edu.cn.
authors: Zhigang
authors: Z
authors: She
mesh_terms: D020909:Acarbose / Q000494:pharmacology; D000818:Animals; D037421:Anthozoa / Q000382:microbiology*; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002681:China; D002942:Circular Dichroism; D055325:Eurotium / Q000302:isolation & purification / Q000378:metabolism*; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009792:Oceans and Seas; D013057:Spectrum Analysis; D000520:alpha-Glucosidases / Q000187:drug effects / Q000378:metabolism
chemical_list: D001572:Benzofurans; D065089:Glycoside Hydrolase Inhibitors; C000594482:eurothiocin A; C000594483:eurothiocin B; D000520:alpha-Glucosidases; D020909:Acarbose