title: LOX-1, oxidant stress, mtDNA damage, autophagy, and immune response in atherosclerosis.
abstract: As a major receptor for oxidized low density lipoprotein (ox-LDL), lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is upregulated in many pathophysiological events, including endothelial cell dysfunction and smooth muscle cell growth, as well as monocyte migration and transformation into foam cells, which are present in atherosclerosis and myocardial ischemia. Excessive production of reactive oxygen species (ROS) increases LOX-1 expression, induces mitochondrial DNA damage, and activates autophagy. Damaged mitochondrial DNA that escapes from autophagy induces an inflammatory response. This paper reviews the potential link between LOX-1, mitochondrial DNA damage, autophagy, and immune response in atherosclerosis.
authors: a Central Arkansas Veterans Healthcare System and the Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72212, USA.
authors: Zufeng
authors: Z
authors: Ding
authors: Shijie
authors: S
authors: Liu
authors: Xianwei
authors: X
authors: Wang
authors: Yao
authors: Y
authors: Dai
authors: Magomed
authors: M
authors: Khaidakov
authors: Francesco
authors: F
authors: Romeo
authors: Jawahar L
authors: JL
authors: Mehta
mesh_terms: D050197:Atherosclerosis / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D001343:Autophagy; D004249:DNA Damage; D004272:DNA, Mitochondrial / Q000378:metabolism*; D006801:Humans; D018384:Oxidative Stress; D051127:Scavenger Receptors, Class E / Q000378:metabolism*
chemical_list: D004272:DNA, Mitochondrial; C495137:OLR1 protein, human; D051127:Scavenger Receptors, Class E
keywords: ADN mitochondrial; LDL oxydées; LOX-1; atherosclerosis; athérosclérose; autophagie; autophagy; espèce réactive d’oxygène; immunity; immunité; mitochondrial DNA; oxidized LDL; reactive oxygen species