title: Syntheses and properties of elastic copoly(ester-urethane)s containing a phospholipid moiety and the fabrication of nanosheets.
abstract: In these years, we have investigated the syntheses of novel diamine and diol monomers containing phosphorylcholine (PC) group to obtain biocompatible polymers, the backbone components of which were thermally stable and mechanically strong. In this study, the preparations of elastic copoly(ester-urethane)s containing PC group and polycarbonate segment were carried out by polycondensation and polyaddition using a diol monomer containing PC group and polycarbonate diol. It was found that the obtained polymers exhibited the high-thermal stability up to 200 °C and the elasticity derived from the soft segment. The introduction of PC group was effective to improve the resistance to the adhesions of proteins and platelets on the polymer films, which was the result of surface properties derived from the PC moiety. In addition, we tried to prepare ultra-thin polymer films composed of copoly(ester-urethane)s, so-called nanosheets. As a result, the desired nanosheets were successfully fabricated and the obtained nanosheets exhibited the high adhesive strength, indicating that the nanosheets could conform closely to the desired surfaces due to their exquisite flexibility and low roughness.
authors: a Course of Industrial Chemistry, Graduate School of Engineering , Tokai University , 4-1-1 Kitakaname, Hiratsuka , Kanagawa 259 1292 , Japan.
authors: Wariya
authors: W
authors: Sirithep
authors: Kohei
authors: K
authors: Morita
authors: Atsushi
authors: A
authors: Iwano
authors: Takuya
authors: T
authors: Komachi
authors: Yosuke
authors: Y
authors: Okamura
authors: Yu
authors: Y
authors: Nagase
mesh_terms: D000327:Adsorption; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D060326:Chemistry Techniques, Synthetic; D005340:Fibrinogen / Q000737:chemistry; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology; D010743:Phospholipids / Q000737:chemistry*; D010973:Platelet Adhesiveness / Q000187:drug effects; D011091:Polyesters / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D011140:Polyurethanes / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D013314:Stress, Mechanical; D013499:Surface Properties; D013696:Temperature
chemical_list: D001672:Biocompatible Materials; D010743:Phospholipids; D011091:Polyesters; D011140:Polyurethanes; C081821:microthane foam; D005340:Fibrinogen
keywords: biocompatibility; diol monomer; nanosheet; phosphorylcholine; poly(ester-urethane)