title: The role of high-density lipoprotein cholesterol in risk for posttraumatic stress disorder: taking a nutritional approach toward universal prevention.
abstract: Several cross-sectional studies, but no prospective studies, have reported an association between an abnormal lipid profile and posttraumatic stress disorder (PTSD). We hypothesized that an abnormal lipid profile might predict risk for developing PTSD. In this prospective study, we analyzed data from 237 antidepressant-naïve severely injured patients who participated in the Tachikawa Cohort of Motor Vehicle Accident Study. High-density lipoprotein cholesterol (HDL-C) levels at baseline were significantly lower in patients with PTSD than those without PTSD at 6 months after motor vehicle accident (MVA) and were inversely associated with risk for PTSD. In contrast, triglycerides (TG) at baseline were significantly higher in patients with PTSD than in those without PTSD at 6 months post-MVA and were positively associated with risk for PTSD. There was no clear association between low-density lipoprotein cholesterol or total cholesterol and risk for PTSD. In conclusion, low HDL-C and high TG may be risk factors for PTSD. Determining lipid profiles might help identify those at risk for PTSD after experiencing trauma.
authors: Department of Clinical Epidemiology, Translational Medical Center, National Center of Neurology and Psychiatry, Tokyo, Japan; Department of Public Health, Faculty of Medicine, University of Toyama, Toyama, Japan; CREST, Japan Science and Technology Agency, Tokyo, Japan.
authors: K
authors: K
authors: Hamazaki
authors: National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan; Department of Psychiatry, National Disaster Medical Center, Tokyo, Japan; CREST, Japan Science and Technology Agency, Tokyo, Japan.
authors: D
authors: D
authors: Nishi
authors: Department of Clinical Epidemiology, Translational Medical Center, National Center of Neurology and Psychiatry, Tokyo, Japan; National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan; CREST, Japan Science and Technology Agency, Tokyo, Japan.
authors: N
authors: N
authors: Yonemoto
authors: Department of Clinical Epidemiology, Translational Medical Center, National Center of Neurology and Psychiatry, Tokyo, Japan; CREST, Japan Science and Technology Agency, Tokyo, Japan.
authors: H
authors: H
authors: Noguchi
authors: National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors: Y
authors: Y
authors: Kim
authors: Department of Clinical Epidemiology, Translational Medical Center, National Center of Neurology and Psychiatry, Tokyo, Japan; National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan; Department of Psychiatry, National Disaster Medical Center, Tokyo, Japan; CREST, Japan Science and Technology Agency, Tokyo, Japan. Electronic address: yutaka@ncnp.go.jp.
authors: Y
authors: Y
authors: Matsuoka
mesh_terms: D000063:Accidents, Traffic / Q000523:psychology*; D000328:Adult; D000367:Age Factors; D002784:Cholesterol / Q000378:metabolism; D008076:Cholesterol, HDL / Q000378:metabolism*; D008078:Cholesterol, LDL / Q000378:metabolism*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D012737:Sex Factors; D013313:Stress Disorders, Post-Traumatic / Q000378:metabolism* / Q000523:psychology; D014280:Triglycerides / Q000378:metabolism*; D055815:Young Adult
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D002784:Cholesterol
keywords: Epidemiology ;Lipid profile; Posttraumatic stress disorder