title: Mitogen Activated Protein Kinase Family Proteins and c-jun Signaling in Injury-induced Schwann Cell Plasticity.
abstract: Schwann cells (SCs) in the peripheral nerves myelinate axons during postnatal development to allow saltatory conduction of nerve impulses. Well-organized structures of myelin sheathes are maintained throughout life unless nerves are insulted. After peripheral nerve injury, unidentified signals from injured nerves drive SC dedifferentiation into an immature state. Dedifferentiated SCs participate in axonal regeneration by producing neurotrophic factors and removing degenerating nerve debris. In this review, we focus on the role of mitogen activated protein kinase family proteins (MAP kinases) in SC dedifferentiation. In addition, we will highlight neuregulin 1 and the transcription factor c-jun as upstream and downstream signals for MAP kinases in SC responses to nerve injury.
authors: Department of Pharmacology, Mitochondria Hub Regulation Center (MHRC), College of Medicine, Dong-A University, Busan 602-714, Korea.
authors: Hye Jeong
authors: HJ
authors: Lee
authors: Department of Physiology, Mitochondria Hub Regulation Center (MHRC), College of Medicine, Dong-A University, Busan 602-714, Korea.
authors: Yoon Kyung
authors: YK
authors: Shin
authors: Department of Physiology, Mitochondria Hub Regulation Center (MHRC), College of Medicine, Dong-A University, Busan 602-714, Korea.
authors: Hwan Tae
authors: HT
authors: Park
keywords: Schwann cell; c-jun; dedifferentiation; mitogen activated protein kinase family proteins; nerve injury; plasticity