title: Screening for the role of transporters in hepatic and renal drug handling.
abstract: Transport proteins expressed in liver and kidney have been studied in great detail on the molecular and cellular level, using membrane vesicles and (transport protein transfected) cell lines. Regulation of transport is studied best in cell systems, whereas an accurate determination of overall hepatic or renal drug clearance can be studied in organs. Hence, translation of this information into a physiological and pharmacological context of individual transporters in hepatic and renal drug handling still needs to be addressed adequately.:
authors: Department of Pharmacology and Toxicology 233, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address:r.masereeuw@ncmls.ru.nl.
authors: Rosalinde
authors: R
authors: Masereeuw
authors: Department of Pharmacology and Toxicology 233, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
authors: Frans
authors: F
authors: Russel