title: Effect of a low dose combined oral contraceptive pill on the hormonal profile and cycle outcome following COS with a GnRH antagonist protocol in women over 35 years old.
abstract: This prospective study examines if pre-treatment with two different doses of an oral contraceptive pill (OCP) modifies significantly the hormonal profile and/or the IVF/ICSI outcome following COS with a GnRH antagonist protocol. Infertile patients were allocated to receive either OCP containing 0.03 mg of ethinylestradiol and 3 mg of drospirenone, or OCP containing 0.02 mg of ethinylestradiol and 3 mg of drospirenone prior to initiation of controlled ovarian stimulation (COS) with recombinant gonadotropins on a variable multi-dose antagonist protocol (Ganirelix), while the control group underwent COS without OCP pretreatment. Lower dose OCP was associated with recovery of FSH on day 3 instead of day 5, but the synchronization of the follicular cohort, the number of retrieved oocytes and the clinical pregnancy rate were similar to higher dose OCP.
authors: 2nd Department of Obstetrics and Gynecology, Aretaieion Hospital, University of Athens , Greece.
authors: Panagiotis
authors: P
authors: Bakas
authors: Dimitrios
authors: D
authors: Hassiakos
authors: Charalampos
authors: C
authors: Grigoriadis
authors: Nikolaos F
authors: NF
authors: Vlahos
authors: Angelos
authors: A
authors: Liapis
authors: George
authors: G
authors: Creatsas
mesh_terms: D000328:Adult; D000736:Androstenes / Q000008:administration & dosage / Q000627:therapeutic use; D003277:Contraceptives, Oral, Combined / Q000008:administration & dosage* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004997:Ethinyl Estradiol / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors* / Q000627:therapeutic use; D006727:Hormone Antagonists / Q000627:therapeutic use*; D006801:Humans; D008597:Menstrual Cycle / Q000187:drug effects*; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D016896:Treatment Outcome
chemical_list: D000736:Androstenes; D003277:Contraceptives, Oral, Combined; D006727:Hormone Antagonists; D007987:Gonadotropin-Releasing Hormone; D004997:Ethinyl Estradiol; D005640:Follicle Stimulating Hormone; C061018:ganirelix; C035144:drospirenone
keywords: COS; Contraceptive pill; GnRH antagonist; ICSI; IVF; ganirelix; ovarian stimulation