title: CX3CR1(+) B cells show immune suppressor properties.
abstract: The immune regulatory functions of B cells are not fully understood yet. The present study aims to characterize a subtype of B cells that expresses CX3CR1. In this study, peripheral blood samples were collected from patients with food allergies and healthy subjects. Peripheral B cells were analyzed by flow cytometry. T cell proliferation was assessed by carboxyfluorescein succinimidyl ester dilution assay. The results showed that the CX3CR1(+) B cells were detected in the peripheral blood samples of healthy subjects and were significantly less in patients with food allergies. CX3CR1(+) B cells expressed high levels of TGF-β and integrin αvβ6. CX3CR1(+) B cells could efficiently suppress other effector CD4(+) T cell activation. We conclude that human peripheral CX3CR1(+) B cells have immune suppressor properties.
authors: Department of Gastroenterology, First Affiliated Hospital, People's Liberation Army General Hospital, Beijing 100037, China. Electronic address: zhiqiangwu32@163.com.
authors: Zhiqiang
authors: Z
authors: Wu
mesh_terms: D000328:Adult; D000951:Antigens, Neoplasm / Q000096:biosynthesis / Q000276:immunology; D016175:B-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000473:pathology; D000073883:CX3C Chemokine Receptor 1; D049109:Cell Proliferation; D005260:Female; D005512:Food Hypersensitivity / Q000097:blood / Q000276:immunology* / Q000473:pathology; D005786:Gene Expression Regulation / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D016023:Integrins / Q000096:biosynthesis / Q000276:immunology; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D019707:Receptors, Chemokine / Q000276:immunology* / Q000378:metabolism
chemical_list: D000951:Antigens, Neoplasm; D000073883:CX3C Chemokine Receptor 1; C095235:CX3CR1 protein, human; D016023:Integrins; D019707:Receptors, Chemokine; C073878:integrin alphavbeta6
keywords: Allergy; Cytokine; Flow Cytometry; Lymphocyte; Western Blot