title: One-pot synthesis of 2-amino-4(3H)-quinazolinones via ring-opening of isatoic anhydride and palladium-catalyzed oxidative isocyanide-insertion.
abstract: An efficient and practical two-step process has been developed for the synthesis of 2-amino-4(3H)-quinazolinones via ring-opening of isatoic anhydride and palladium-catalyzed oxidative isocyanide-insertion in one pot. This regioselective procedure could construct a wide range of 2-amino-4(3H)-quinazolinones in moderate to excellent yields. Furthermore, the methodology also had distinct advantages of easily accessible starting materials and operational simplicity.
authors: Chemical Engineering College, Nanjing University of Science and Technology, Nanjing, China. c.cai@mail.njust.edu.cn.
authors: Fei
authors: F
authors: Ji
authors: Mei-Fang
authors: MF
authors: Lv
authors: Wen-Bin
authors: WB
authors: Yi
authors: Chun
authors: C
authors: Cai
mesh_terms: D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D018360:Crystallography, X-Ray; D003486:Cyanides / Q000737:chemistry*; D003500:Cyclization; D008968:Molecular Conformation; D010078:Oxazines / Q000737:chemistry*; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D003486:Cyanides; D010078:Oxazines; D011799:Quinazolines; D010165:Palladium; C037902:isatoic anhydride