title: In vitro activity studies of hyperthermal near-infrared nanoGUMBOS in MDA-MB-231 breast cancer cells.
abstract: A new kind of material called nanoGUMBOS, comprised entirely of cations and anions, has been developed by pairing various functional ions that exhibit fluorescence activity with biocompatible ions, in a process very much akin to that employed in ionic liquid chemistry. In the present study, spectral and biological properties of NIR absorbing nanoGUMBOS were evaluated using electron microscopy, dynamic light scattering, absorbance, thermal imaging, and live/dead fluorescence assays in conjunction with malignant MDA-MB-231 and non-malignant HS-578-BST epithelial human breast cells. The primary focus of this study was to maximize heat generation using NIR laser irradiation and minimize non-specific cytotoxicity using biocompatible constituent ions (e.g. amino acids, vitamins, or organic acids). Concurrently, in order to generate highly responsive nanomaterials for NIR-laser-triggered hyperthermia, optimization of the nanoparticle size, shape, and uniformity was carried out. Evaluation of data from hyperthermal studies of NIR absorbing nanoGUMBOS shows that these materials can achieve temperatures above the threshold for killing cancerous cells. Additionally, in vitro cell based assays demonstrated their promising hyperthermal effects on cancer derived epithelial cells.
authors: Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA. iwarner@lsu.edu.
authors: Jonathan C
authors: JC
authors: Dumke
authors: Ammar
authors: A
authors: Qureshi
authors: Suzana
authors: S
authors: Hamdan
authors: Kresimir
authors: K
authors: Rupnik
authors: Bilal
authors: B
authors: El-Zahab
authors: Daniel J
authors: DJ
authors: Hayes
authors: Isiah M
authors: IM
authors: Warner
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D005260:Female; D005492:Folic Acid / Q000737:chemistry; D006801:Humans; D006979:Hyperthermia, Induced; D007834:Lasers; D008856:Microscopy, Fluorescence; D049329:Nanostructures / Q000737:chemistry* / Q000633:toxicity
chemical_list: D005492:Folic Acid