title: A vision for cyclodextrin nanoparticles in drug delivery systems and pharmaceutical applications.
abstract: Cyclodextrins (CDs) have brought a revolution in the pharmaceutical field over the last decade. Natural and modified CDs (α-CD and β-CD) have been studied and some have gained US FDA approval or achieved 'Generally Regarded as Safe' (GRAS) status. Another characteristic of CDs is the ease with which they can be induced to form supramolecular structures for its use in drug delivery. CDs, grafted or crosslinked with polymers, are now being developed into 'smart' systems for efficient targeted drug delivery, especially for hydrophobic drugs. Amphiphilic CDs have the ability to form nanospheres or nanocapsules via a simple nanoprecipitation technique. This review deals with different types of CDs, and their efficacy, physicochemical properties and transformation into nanoparticles with interesting in vitro and in vivo applications.
authors: Department of Applied Chemistry, Center for Nanomaterials Science, University of Johannesburg, Doornfontein 2028, Gauteng, South Africa.
authors: Jaya Raju
authors: JR
authors: Lakkakula
authors: Rui Werner
authors: RW
authors: Maçedo Krause
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D003505:Cyclodextrins / Q000737:chemistry* / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods; D018014:Gene Transfer Techniques; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry* / Q000378:metabolism / Q000648:ultrastructure; D009369:Neoplasms / Q000188:drug therapy; D009696:Nucleic Acids / Q000008:administration & dosage; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D011108:Polymers / Q000737:chemistry / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D003505:Cyclodextrins; D004337:Drug Carriers; D009696:Nucleic Acids; D004364:Pharmaceutical Preparations; D011108:Polymers
keywords: amphiphilic cyclodextrins; cancer; cyclodextrin nanoparticles; drug delivery systems; gene delivery; inclusion complex; smart polymers; supramolecular structures