title: Hispidanins A-D: four new asymmetric dimeric diterpenoids from the rhizomes of Isodon hispida.
abstract: Hispidanins A-D (1-4), four unprecedented asymmetric dimeric diterpenoids, were obtained from the rhizomes of Isodon hispida. Their structures were elucidated by extensive spectroscopic analysis (1D and 2D NMR, MS, UV, IR), as well as single-crystal X-ray diffraction analysis. Hispidanin B showed significant cytotoxicities against tumor cell lines SGC7901, SMMC7721, and K562, with IC50 values of 10.7, 9.8, and 13.7 μM, respectively.
authors: Institute of Materia Medica, Dali University , Dali, Yunnan 671000, P. R. China.
authors: Bo
authors: B
authors: Huang
authors: Chao-Jiang
authors: CJ
authors: Xiao
authors: Zhen-Yuan
authors: ZY
authors: Huang
authors: Xin-Yan
authors: XY
authors: Tian
authors: Xia
authors: X
authors: Cheng
authors: Xiang
authors: X
authors: Dong
authors: Bei
authors: B
authors: Jiang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D037602:Isodon / Q000737:chemistry*; D020014:K562 Cells; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D027343:Rhizome / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes