title: Vincristine-induced polyneuropathy in a child with stage I Wilms' tumour presenting with unilateral abducens nerve palsy.
abstract: A 4-year-old boy presented with right esotropia while receiving vincristine and dactinomycin for stage I Wilms' tumour according to the National Wilms Tumour Study-5 protocol. On examination, he had isolated limitation of his right lateral gaze. CT of the brain and cerebrospinal fluid examination were normal. A nerve conduction velocity study which was performed on the peripheral nerves revealed predominant motor polyneuropathy compatible with axonal loss involving the upper limbs. The patient had received a cumulative vincristine dose of 17 mg/m(2) before developing esotropia. Vincristine-induced abducens nerve mononeuropathy and subclinical motor polyneuropathy was suspected. Unilateral esotropia markedly improved after the discontinuation of vincristine and a short course of oral pyridoxine treatment.
authors: Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
authors: Panadeekarn
authors: P
authors: Panjawatanan
authors: Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
authors: Pimlak
authors: P
authors: Charoenkwan
authors: Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
authors: Kamornwan
authors: K
authors: Katanyuwong
authors: Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
authors: Worawut
authors: W
authors: Choeyprasert
mesh_terms: D020434:Abducens Nerve Diseases / Q000139:chemically induced*; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects* / Q000627:therapeutic use; D002675:Child, Preschool; D004948:Esotropia / Q000139:chemically induced*; D006801:Humans; D008297:Male; D011115:Polyneuropathies / Q000139:chemically induced*; D014750:Vincristine / Q000009:adverse effects* / Q000627:therapeutic use; D009396:Wilms Tumor / Q000188:drug therapy*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014750:Vincristine