title: Burkholderia cepacia complex isolation in non-polypoid chronic rhinosinusitis.
abstract: OBJECTIVE
  Burkholderia cepacia complex (Bcc) infections of the head and neck have been infrequently reported in immunocompetent patients, while their association with cystic fibrosis is quite well known. One of the main problems associated with Bcc is their intrinsic resistance to most clinically-available antimicrobials. Bcc has already been isolated in sinonasal polyposis, while here we report for the first time on its isolation in patients with chronic rhinosinusitis (CRS) but no nasal polyposis.
  
  
  METHODS
  Thirty-four consecutive surgically-treated CRS patients without cystic fibrosis were recruited.
  
  
  RESULTS
  Bcc was isolated in 4 cases of CRS without polyposis, and in another case in sinonasal polyposis. All tested Bcc strains isolated in non-polypotic CRS were resistant to ciprofloxacin, amikacin, ertapenem, amoxicillin/clavulanate, cefotaxime, and gentamicin.
  
  
  CONCLUSIONS
  The novel finding of Bcc species in CRS without polyposis as well suggests that the mechanism by which these bacteria adhere to the epithelium of the upper respiratory tract may be important in the host's colonization.
authors: Department of Neurosciences, Otolaryngology Section, University of Padova, Padova, Italy.
authors: Giancarlo
authors: G
authors: Ottaviano
authors: Department of Neurosciences, Otolaryngology Section, Treviso Hospital Branch, University of Padova, Treviso, Italy.
authors: Claudia
authors: C
authors: Staffieri
authors: Department of Neurosciences, Otolaryngology Section, University of Padova, Padova, Italy.
authors: Niccolò
authors: N
authors: Favaretto
authors: Department of Neurosciences, Otolaryngology Section, University of Padova, Padova, Italy.
authors: Elena
authors: E
authors: Fasanaro
authors: Department of Histology, Microbiology and Medical Biotechnology, Microbiology Section, University of Padova, Padova, Italy.
authors: Davide
authors: D
authors: Abate
authors: Department of Neurosciences, Otolaryngology Section, University of Padova, Padova, Italy.
authors: Cosimo
authors: C
authors: de Filippis
authors: Department of Neurosciences, Otolaryngology Section, University of Padova, Padova, Italy.
authors: Alberto
authors: A
authors: Staffieri
authors: Department of Neurosciences, Otolaryngology Section, University of Padova, Padova, Italy. Electronic address: gino.marioni@unipd.it.
authors: Gino
authors: G
authors: Marioni
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019121:Burkholderia Infections / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery*; D042602:Burkholderia cepacia complex / Q000302:isolation & purification*; D002908:Chronic Disease; D003131:Combined Modality Therapy; D024881:Drug Resistance, Bacterial; D004724:Endoscopy; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D012220:Rhinitis / Q000382:microbiology*; D012852:Sinusitis / Q000382:microbiology*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents