title: Prolactin serum levels correlate with inflammatory status in drug-naïve first-episode schizophrenia.
abstract: OBJECTIVE
  The present study was to examine the relationship between serum levels of prolactin and the inflammatory status in drug-naïve, first-episode schizophrenia patients with normal weight.
  
  
  METHODS
  Patients with normal weight, drug-naïve, first-episode schizophrenia and healthy controls were enrolled in the study. Serum levels of prolactin (PRL) were measured using electrical chemiluminescence immunoassay. Serum levels of interleukin-1β (IL-1β), tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were examined using enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  Sixty patients with normal weight, drug-naïve, first-episode schizophrenia and 60 healthy controls were enrolled. The schizophrenia group had higher serum levels of PRL, IL-1β, IL-6 and TNF-α compared with the control group. There was a gender difference of hyperprolactinemia in schizophrenia group. There were positive relationships between serum levels of PRL and serum levels of IL-1β, IL-6 and TNF-α within the schizophrenia group. Within the schizophrenia group, TNF-α was the strongest predictor among the three cytokines for serum levels of prolactin after controlling for gender, age, education, smoking status and disease duration.
  
  
  CONCLUSIONS
  Patients with normal weight, drug-naïve, first-episode schizophrenia present elevated serum levels of PRL, which might be related to the up-regulated inflammatory status in this patient population.
authors: The First Affiliated Hospital/Zhengzhou University , Zhengzhou , China.
authors: Xueqin
authors: X
authors: Song
authors: Xiaoduo
authors: X
authors: Fan
authors: Jianjiang
authors: J
authors: Zhang
authors: Hui
authors: H
authors: Zheng
authors: Xue
authors: X
authors: Li
authors: Lijuan
authors: L
authors: Pang
authors: Xumei
authors: X
authors: Chen
authors: Wei
authors: W
authors: Zhang
authors: Amy
authors: A
authors: Harrington
authors: Douglas
authors: D
authors: Ziedonis
authors: Luxian
authors: L
authors: Lv
mesh_terms: D000328:Adult; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood; D007249:Inflammation / Q000097:blood*; D053583:Interleukin-1beta / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D011388:Prolactin / Q000097:blood*; D012559:Schizophrenia / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D055815:Young Adult
chemical_list: D016207:Cytokines; D053583:Interleukin-1beta; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D011388:Prolactin
keywords: IL-1β; IL-6; TNF-α; prolactin; schizophrenia