title: Targeting transcription factors in cancer: Challenges and evolving strategies.
abstract: As investigators uncover the molecular pathways leading to cancer, an abundance of potential molecular targets is accumulating. Among these targets, transcription factors are especially promising. This review discusses the reasons for focusing targeting efforts on transcription factors and highlights some salient examples. The advantages and problems with current methods for targeting are summarized. Finally, we discuss the drug delivery technologies in development that may one day make transcription factor targeting a therapeutic reality.:
authors: Section of Hematology-Oncology, Department of Pediatrics, Texas Children's Cancer Center and Baylor College of Medicine, Houston, TX, USA.
authors: Michele S
authors: MS
authors: Redell
authors: Section of Infectious Diseases, Department of Medicine, and Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, BCM 286; Room N1319, Houston, TX 77030, USA. Electronic address:dtweardy@bcm.tmc.edu.
authors: David J
authors: DJ
authors: Tweardy