title: Patient preferences for noninsulin diabetes medications: a systematic review.
abstract: OBJECTIVE
  An evidence-based synthesis of patient preferences for management of hyperglycemia is needed. Our objective was to systematically review patient preferences for noninsulin diabetes medications in adults with type 2 diabetes.
  
  
  METHODS
  We searched the PubMed, Embase, CINAHL, and EconLit databases for articles published on or before 23 January 2013. We included English-language studies of adult patients with type 2 diabetes that assessed patient preferences for diabetes medication treatment. Titles, abstracts, and articles were reviewed by at least two independent reviewers. Study data and quality were abstracted with standard protocols.
  
  
  RESULTS
  Of 2,811 titles identified in our original search, 10 articles met inclusion criteria for the systematic review. Studies were conducted from 2007 to 2012 among diverse patient populations in the U.S., Sweden, Denmark, and the U.K. Methods used to assess patient preferences included discrete choice experiments (e.g., conjoint analysis), time tradeoff exercises, standard gamble, and patient surveys. Key attributes of diabetes medication associated with patient preferences included treatment benefits (e.g., glycemic control and weight loss/control), treatment burden (e.g., administration, frequency, and cost), and side effects (e.g., weight gain, gastrointestinal effects, and hypoglycemia).
  
  
  CONCLUSIONS
  Various clinical and quality of life-related factors influence patient preferences for noninsulin diabetes medications. Treatment efficacy with regard to glycemic control and weight loss/control and the risk of treatment-related hypoglycemia and gastrointestinal effects are reported to be important drivers of patient treatment selections. Future work is needed to identify practical methods for incorporating patient preferences into treatment decision making and patient-centered care.
authors: Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MDWelch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD tpurnel1@jhmi.edu.
authors: Tanjala S
authors: TS
authors: Purnell
authors: Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
authors: Susan
authors: S
authors: Joy
authors: Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
authors: Emily
authors: E
authors: Little
authors: Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
authors: John F P
authors: JF
authors: Bridges
authors: Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MDWelch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MDDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
authors: Nisa
authors: N
authors: Maruthur
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000187:drug effects; D002755:Choice Behavior; D003657:Decision Making; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D057240:Patient Preference; D018802:Patient-Centered Care / Q000379:methods; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents