title: Fusobacterium and Enterobacteriaceae: important players for CRC?
abstract: The gut microbiota plays an essential role in regulating intestinal homeostasis through its capacity to modulate various biological activities ranging from barrier, immunity and metabolic function. Not surprisingly, microbial dysbiosis is associated with numerous intestinal disorders including inflammatory bowel diseases (IBD) and colorectal cancer (CRC). In this piece, we will review recent evidence that gut microbial dysbiosis can influence intestinal disease, including colitis and CRC. We will discuss the biological events implicated in the development of microbial dysbiosis and the emergence of CRC-associated microorganisms, focusing on Escherichia coli and Fusobacterium nucleatum. Finally, the mechanisms by which E. coli and F. nucleatum exert potentially carcinogenic effects on the host will be reviewed.
authors: Department of Molecular and Cellular Biology, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1, Canada.
authors: Emma
authors: E
authors: Allen-Vercoe
authors: Department of Medicine and Department of Infectious Diseases and Pathology, University of Florida, Gainesville, FL 32611, USA. Electronic address: Christian.Jobin@medicine.ufl.edu.
authors: Christian
authors: C
authors: Jobin
mesh_terms: D000818:Animals; D063646:Carcinogenesis; D003092:Colitis / Q000209:etiology / Q000276:immunology* / Q000382:microbiology; D015179:Colorectal Neoplasms / Q000209:etiology / Q000276:immunology* / Q000382:microbiology; D064806:Dysbiosis / Q000150:complications / Q000276:immunology* / Q000382:microbiology; D004755:Enterobacteriaceae / Q000276:immunology*; D004756:Enterobacteriaceae Infections / Q000150:complications / Q000276:immunology* / Q000382:microbiology; D005673:Fusobacterium / Q000276:immunology*; D005674:Fusobacterium Infections / Q000150:complications / Q000276:immunology* / Q000382:microbiology; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000382:microbiology; D007413:Intestinal Mucosa / Q000276:immunology / Q000382:microbiology
keywords: Cancer; Inflammation; Intestine; Microbiome