title: Safety and efficacy of the Yukon Choice Flex sirolimus-eluting coronary stent in an all-comers population cohort.
abstract: OBJECTIVE
  The use of biodegradable-polymer drug-eluting stents has been shown to provide favorable results when compared with durable polymer drug-eluting stents and long-term follow up data have recently shown significant reductions in terms of very late stent thrombosis. Aim of the present study was to assess the safety and efficacy profile of a novel biodegradable polymer DES, the Yukon Choice Flex sirolimus-eluting stent.
  
  
  METHODS
  We report here the one-year clinical outcomes associated with the use of the Yukon Choice Flex sirolimus-eluting stent in an all-comers patient population. The present stent represents a further refinement of the stent platform tested in the ISAR TEST 3 and 4 randomized clinical trials. A total of 778 consecutive patients undergoing implantation of this stent were enrolled in the present observational study and prospectively followed for one year.
  
  
  RESULTS
  The use of the Yukon Choice Flex stent in a patient population with complex coronary lesion morphology was associated with optimal immediate angiographic results. At one year follow up the rates of death, myocardial infarction, definite stent thrombosis and ischemia-driven target lesion revascularization were respectively 2.4%, 1.9%, 0.3% and 11.3%.
  
  
  CONCLUSIONS
  The use of the sirolimus-eluting biodegradable polymer Yukon Choice Flex stent in an all-comers population of patients with complex coronary artery disease is associated with a favorable safety and efficacy profile up to one year follow up.
authors: Deutsches Herzzentrum, Technische Universität, Lazarettstrasse 36, 80636 Munich, Germany.
authors: E
authors: E
authors: Xhepa
authors: Deutsches Herzzentrum, Technische Universität, Lazarettstrasse 36, 80636 Munich, Germany.
authors: T
authors: T
authors: Tada
authors: Deutsches Herzzentrum, Technische Universität, Lazarettstrasse 36, 80636 Munich, Germany.
authors: S
authors: S
authors: Cassese
authors: Deutsches Herzzentrum, Technische Universität, Lazarettstrasse 36, 80636 Munich, Germany.
authors: L
authors: L
authors: King
authors: Deutsches Herzzentrum, Technische Universität, Lazarettstrasse 36, 80636 Munich, Germany.
authors: I
authors: I
authors: Ott
authors: Deutsches Herzzentrum, Technische Universität, Lazarettstrasse 36, 80636 Munich, Germany.
authors: M
authors: M
authors: Fusaro
authors: Deutsches Herzzentrum, Technische Universität, Lazarettstrasse 36, 80636 Munich, Germany. Electronic address: kastrati@dhm.mhn.de.
authors: A
authors: A
authors: Kastrati
authors: Deutsches Herzzentrum, Technische Universität, Lazarettstrasse 36, 80636 Munich, Germany.
authors: R A
authors: RA
authors: Byrne
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020341:Absorbable Implants; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery; D023903:Coronary Restenosis / Q000401:mortality; D054855:Drug-Eluting Stents; D005500:Follow-Up Studies; D007166:Immunosuppressive Agents / Q000494:pharmacology; D007194:India / Q000453:epidemiology; D053208:Kaplan-Meier Estimate; D011446:Prospective Studies; D011474:Prosthesis Design; D011475:Prosthesis Failure; D020123:Sirolimus / Q000494:pharmacology; D015996:Survival Rate / Q000639:trends; D013997:Time Factors; D016896:Treatment Outcome; D016032:Randomized Controlled Trials as Topic
chemical_list: D007166:Immunosuppressive Agents; D020123:Sirolimus
keywords: Bioresorbable-polymer drug-eluting stent; Percutaneous coronary intervention; Stent thrombosis