title: Remifentanil versus Fentanyl for Assisted Reproductive Technologies: Effect on Hemodynamic Recovery from Anesthesia and Outcome of ART Cycles.
abstract: BACKGROUND
  We conducted this study to compare the outcome of assisted reproductive technology (ART) procedures and recovery from anesthesia in women who received opioid analgesia with remifentanil versus fentanyl.
  
  
  METHODS
  This double-blind, randomized clinical trial was carried out in the Yazd Research and Clinical Center for Infertility, Yazd, Iran. We studied 145 women who were participants in an ART program. During the first phase of the study, all patients underwent induction of anesthesia with thiopental and received analgesia with remifentanil or fentanyl. The primary endpoint was pregnancy rate per transfer. The numbers of oocytes collected, fertilized and cleaved were recorded, as was the number of oocytes transferred and recovery profile. In the second phase of the study, all patients were followed for outcome of ART cycle.
  
  
  RESULTS
  This study suggested that in women undergoing transvaginal ultrasound-guided oocyte retrieval procedures, the likelihood of a successful pregnancy was higher with a remifentanil-based monitored anesthesia care (MAC) technique than with a fentanyl-based MAC technique. The recovery from anesthesia was significantly better in the remifentanil group versus fentanyl group.
  
  
  CONCLUSIONS
  The results of this study suggest that remifentanil in clinical practice is superior to fentanyl (
  
  
  BACKGROUND
  IRCT201009283468N3).
authors: Anesthesiology and Critical Care Department, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
authors: Mohammad Hossein
authors: MH
authors: Jarahzadeh
authors: Obstetrics and Gynecology Department, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
authors: Robab
authors: R
authors: Davar
authors: Anesthesiology and Critical Care Department, Tehran University of Medical Sciences and Health Services, Tehran, Iran.
authors: Mohammad Reza
authors: MR
authors: Hajiesmaeili
authors: Anesthesiology and Critical Care Department, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
authors: Ahmad
authors: A
authors: Entezari
authors: Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
authors: Fatemeh
authors: F
authors: Musavi
keywords: Analgesia; Assisted Reproductive Technologies; Fentanyl; Remifentanil