title: The Drosophila TNF ortholog Eiger: emerging physiological roles and evolution of the TNF system.
abstract: The TNF and TNFR superfamilies of proteins are conserved throughout evolution. The first invertebrate orthologs of TNF and TNFR, Eiger and Wengen, were identified in Drosophila, which enabled us to take advantage of its powerful genetics. Indeed, genetic studies on Eiger in the last decade have discovered their signaling mechanisms through activation of the JNK pathway and unveiled the role of Eiger-JNK signaling in a variety of cellular and tissue processes such as cell death, cell proliferation, tissue growth regulation, host defense, pain sensitization, and canalization. In this review, we will describe the in vivo signaling of Eiger and its physiological roles in fly development and homeostasis, and will discuss the evolution of the TNF/TNFR systems.
authors: Laboratory of Genetics, Graduate School of Biostudies, Kyoto University, Yoshida-Konoecho, Sakyo-ku, Kyoto 606-8501, Japan; Precursory Research for Embryonic Science and Technology (PRESTO), Basic Research Program, Japan Science and Technology Agency, Chiyoda-ku, Tokyo 102-0075, Japan. Electronic address: igaki@lif.kyoto-u.ac.jp.
authors: Tatsushi
authors: T
authors: Igaki
authors: Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan; Core Research for Evolutional Science and Technology (CREST), Basic Research Program, Japan Science and Technology Agency, Chiyoda-ku, Tokyo 102-0075, Japan. Electronic address: miura@molo.f.u-tokyo.ac.jp.
authors: Masayuki
authors: M
authors: Miura
mesh_terms: D000818:Animals; D005075:Biological Evolution; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology; D048031:JNK Mitogen-Activated Protein Kinases / Q000378:metabolism; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology; D018124:Receptors, Tumor Necrosis Factor / Q000235:genetics* / Q000276:immunology / Q000378:metabolism / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics* / Q000276:immunology* / Q000378:metabolism
chemical_list: D029721:Drosophila Proteins; D008565:Membrane Proteins; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; C464573:egr protein, Drosophila; C464933:wgn protein, Drosophila; D048031:JNK Mitogen-Activated Protein Kinases
keywords: Cancer; Cell death; Drosophila; JNK; TNF; TNFR