title: Genetic polymorphisms and plasma levels of interleukin-22 contribute to the development of nonsmall cell lung cancer.
abstract: Interleukin (IL)-22, a relatively new member of the IL-10 family, has been implicated in inflammation and tumorigenesis. The aim of this study was to identify genetic polymorphisms in IL-22 and to measure plasma levels of IL-22 in patients with nonsmall cell lung cancer (NSCLC). Patients with NSCLC had a significantly higher frequency of IL-22 rs2227484 CT genotype (odds ratio [OR]=1.917, 95% confidence interval [CI] 1.001-3.670, p=0.038) and T allele (OR=1.878, 95% CI 1.010-3.491, p=0.049) as compared with controls. The rs2227484 genotype was associated with a 2.263-fold increased risk for advanced NSCLC (p=0.041). Among different subtypes of NSCLC, these associations were more obvious in the adenocarcinoma. Moreover, patients with high frequencies of genotypic polymorphisms had high plasma levels of IL-22. IL-22 polymorphisms and corresponding high levels of IL-22 in plasma may contribute to the development of NSCLC, especially adenocarcinoma.
authors: 1 Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine , Shanghai, China .
authors: Fei
authors: F
authors: Liu
authors: Xufeng
authors: X
authors: Pan
authors: Lin
authors: L
authors: Zhou
authors: Jian
authors: J
authors: Zhou
authors: Bin
authors: B
authors: Chen
authors: Jianxin
authors: J
authors: Shi
authors: Wen
authors: W
authors: Gao
authors: Liming
authors: L
authors: Lu
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics*; D002289:Carcinoma, Non-Small-Cell Lung / Q000453:epidemiology / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000235:genetics; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007249:Inflammation / Q000235:genetics; D007378:Interleukins / Q000097:blood* / Q000235:genetics*; D008175:Lung Neoplasms / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D016324:Sequence Tagged Sites; D000097043:Interleukin-22
chemical_list: D007378:Interleukins; D000097043:Interleukin-22