title: Subcutaneous dermatofibroma: a rare case report with review of literature.
abstract: A purely Sub-cutaneous benign fibrous histiocytoma (BFH; dermatofibroma) is rarely reported, as it is usually a dermally located mesenchymal tumour and in absence of supportive immunohistochemical (IHC) studies, it is often misdiagnosed. We are describing a case of a 19-year-old female who presented to the skin outpatient department with a painful swelling on the medial side of her thigh. Fine needle aspiration (FNA) revealed a sub-cutaneous spindle cell (mesenchymal) lesion which was corroborated on histopathology, with differentials of BFH and dermatofibrosarcoma protruberans (DFSP). BFH constitutes a diagnostic dilemma for both clinicians and pathologists, because the lesions share common clinical symptoms, radiological characteristics and histological features with many varied entities. For its subtyping and confirmation; immunohistochemical (IHC) studies were undertaken. In the present case, positivity of IHC markers, vimentin and smooth muscle actin emphatically proved that BFH arose exclusively from the subcutaneous region, with no dermal origin. Also, a negative CD34 immunostaining, along with low B-cell lymphoma 2 (Bcl-2) expression ruled out DFSP (both are strongly expressed in DFSP), MFH and other malignant mesenchymal lesions. Negative CD 68 staining ruled out giant cell lesions and their congeners. This case is worth reporting, as it not only describes a rare case presentation of BFH, but as it also highlights the importance of IHC, thus helping to comprehensively clinch the diagnosis by systematically ruling out other differentials.
authors: Asscoiate Professor, Department of Pathology, Sri Guru Ram Das Institute of Medical Sciences and Research , Amritsar, Punjab, India .
authors: Harjot
authors: H
authors: Kaur
authors: Professor, Department of Dermatology, Sri Guru Ram Das Institute of Medical Sciences and Research , Amritsar, Punjab, India .
authors: Jasleen
authors: J
authors: Kaur
authors: Professor, Department of Pathology, Sri Guru Ram Das Institute of Medical Sciences and Research , Amritsar, Punjab, India .
authors: Karamjit Singh
authors: KS
authors: Gill
authors: Associate Professor, Department of Pathology, Sri Guru Ram Das Institute of Medical Sciences and Research , Amritsar, Punjab, India .
authors: Rahul
authors: R
authors: Mannan
authors: Assistant Professor, Department of Dermatology, Sri Guru Ram Das Institute of Medical Sciences and Research , Amritsar, Punjab, India .
authors: Swati
authors: S
authors: Arora
keywords: Benign fibrous histiocytoma; Immunohistochemistry; Subcutaneous