title: Relationship of high sensitivity C-reactive protein with cardiac biomarkers in patients presenting with acute coronary syndrome.
abstract: OBJECTIVE
  To determine high sensitivity C-reactive protein (hsCRP) levels in patients with acute myocardial infarction (AMI) and its correlation with classical enzyme markers of myocardial damage.
  
  
  METHODS
  Observational study.
  
  
  METHODS
  Department of Emergency Medicine at King Khalid University Hospital, King Saud University, Riyadh and Department of Physiology, from August 2010 to December 2011.
  
  
  METHODS
  Consecutive eligible patients with either ST elevation myocardial infarction (STEMI) or non-ST elevation myocardial infarction (NSTEMI) who were admitted to the Emergency Department of King Khalid University Hospital were recruited. A total of 71 subjects were finally selected for the study. The hsCRP, Troponin I (Trop I), creatine kinase myocardial bound (CK-MB), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) concentrations of all patients with an acute myocardial infarction (AMI) were measured.
  
  
  RESULTS
  Among all patients 34 (47.9%) patients had diabetes mellitus, 21 (29.6%) were hypertensive, and 16 (22.5%) had no associated illness. Patients with STEMI had significantly higher levels of CKMB (p=0.0348), LDH (p=0.0471) and hsCRP (p=0.0231) compared to NSTEMI patients. While the differences were non-significant for Trop I (p=0.7022), AST (p=0.9729) and Lp(a) (p=0.5985). Spearman's correlations revealed that CRP correlated significantly with Trop I, CK-MB and LDH. There was a significant predictive relationship of hsCRP with Trop I, LDH and CK-MB while with AST it was nonsignificant.
  
  
  CONCLUSIONS
  High sensitivity CRP levels is a significant predictor of standard markers for myocardial damage and it may be a useful prognostic marker in acute coronary syndromes.
authors: Department of Emergency Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.
authors: Zohair Al
authors: ZA
authors: Aseri
authors: Department of Emergency Physiology, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.
authors: Syed Shahid
authors: SS
authors: Habib
authors: Department of Biochemistry, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.
authors: Abdullah Saleh
authors: AS
authors: Alhomida
authors: Department of Biochemistry, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.
authors: Haseeb Ahmad
authors: HA
authors: Khan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis / Q000378:metabolism*; D017023:Coronary Angiography; D052279:Creatine Kinase, MB Form / Q000097:blood; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis*; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D019210:Troponin I / Q000097:blood
chemical_list: D015415:Biomarkers; D019210:Troponin I; D002097:C-Reactive Protein; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D052279:Creatine Kinase, MB Form