title: Novel regulators of rabbit reproductive functions.
abstract: This is a review of original data concerning new extra- and intracellular regulators of rabbit ovarian functions. Effects of some hormones including leptin, ghrelin, oxytocin, arginine-vasotocin, endothelin (ET-1), gonadotropin releasing hormone (GnRH), adrenocorticotropic hormone (ACTH), growth factors such as insulin-like growth factor-I (IGF-I), epidermal growth factor (EGF), nuclear peroxisome proliferator-activated receptor gamma (PPARγ), pharmacological regulators of some protein kinases such as protein kinase A (PKA), mitogen-activated protein (MAP) kinase, cell division cycle protein 2 homolog (CDC2 kinase, CDK), tyrosine kinases), and plant molecules (resveratrol, rapamycin) on the functions of ovarian cells (proliferation, apoptosis, secretory activity, expression of some protein kinases) and reproductive end points (blood level of reproductive hormones, ovarian morphology, number of ovulations, embryo yield and quality, number and viability of offspring), and their possible interrelationships and practical application in rabbit breeding are reviewed.
authors: Research Institute of Animal Production, Nitra, Slovak Republic; Constantine the Philosopher University in Nitra, Slovak Republic. Electronic address: sirotkin@vuzv.sk.
authors: Alexander V
authors: AV
authors: Sirotkin
authors: Research Institute of Animal Production, Nitra, Slovak Republic; Slovak University of Agriculture in Nitra, Slovak Republic.
authors: Peter
authors: P
authors: Chrenek
authors: Slovak University of Agriculture in Nitra, Slovak Republic.
authors: Adriana
authors: A
authors: Kolesarová
authors: Scuola di Bioscienze e Medicina veterinaria, Università di Camerino, 62024 Matelica, Italy.
authors: Francesco
authors: F
authors: Parillo
authors: Scuola di Bioscienze e Medicina veterinaria, Università di Camerino, 62024 Matelica, Italy.
authors: Massimo
authors: M
authors: Zerani
authors: Dipartimento di Scienze biopatologiche ed Igiene delle produzioni animali e alimentari, Laboratorio di Biotecnologie fisiologiche, Sezione di Fisiologia veterinaria, Università di Perugia, 06100 Perugia, Italy.
authors: Cristiano
authors: C
authors: Boiti
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D005299:Fertility Agents / Q000494:pharmacology; D005938:Glucocorticoids / Q000494:pharmacology; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology; D006062:Gonadotropins / Q000494:pharmacology; D010121:Oxytocin / Q000494:pharmacology; D011817:Rabbits / Q000502:physiology*; D012098:Reproduction / Q000187:drug effects / Q000502:physiology*; D014667:Vasopressins / Q000494:pharmacology; D014668:Vasotocin / Q000494:pharmacology
chemical_list: D005299:Fertility Agents; D005938:Glucocorticoids; D006062:Gonadotropins; D014667:Vasopressins; D007987:Gonadotropin-Releasing Hormone; D010121:Oxytocin; D000324:Adrenocorticotropic Hormone; D014668:Vasotocin
keywords: Fecundity; Growth factor; Hormone; Protein kinases; Rabbit; Reproduction