title: Polybutylcyanoacrylate nanoparticles and drugs of the platinum family: last status.
abstract: Cisplatinum and carboplatinum drugs from platinum-containing family are anti-cancer drugs. Using these drugs causes side effects. Targeted and selective prescription decreases side effects of the drugs. This can be achieved using nanotechnology. In this study, cisplatinum and carboplatinum drugs were loaded on polybutylcyanoacrylate nanoparticles using emulsion polymerization method. To determine amount of loaded drug onto nanoparticle, spectrophotometry method was used. Evaluation of cytotoxicity of such nanoparticles was performed on MCF-7 cell line using MTT assay. Loading percentage of cisplatinum and carboplatinum drugs on nanoparticles were estimated 4 and 6 %, respectively. Cytotoxicity survival rate for cisplatinum and nanoparticle containing cisplatinum at the lowest concentration (p < 0.01) (20 μM) were estimated 64 ± 1 and 67 ± 0.5 %, respectively. These values at the highest concentration (p < 0.01) (160 μM) were measured 28 ± 0.7 and 31 ± 0.4 %. Additionally for carboplatinum and nanoparticles containing carboplatinum at the concentration (p < 0.01) (20 μM) amounts were estimated to be 80 ± 0.6 and 84 ± 0.6 %, while at the concentration (p < 0.01) (160 μM) were identified to be 44 ± 0.5 and 51 ± 0.2 %, respectively. Probably, due to low level of loading, cytotoxicity of both drugs at nano particle status was decreased in comparison with their standard form.
authors: Department of Inorganic Chemistry, North Tehran Branch, Islamic Azad University, Tehran, Iran.
authors: Dashti Rahmat Abadi
authors: DR
authors: Fatemeh
authors: Department of Pilot Nanobiotechnology, Pasteur Institute of Iran, Tehran, Iran.
authors: Hasan
authors: H
authors: Ebrahimi Shahmabadi
authors: Department of Inorganic Chemistry, North Tehran Branch, Islamic Azad University, Tehran, Iran.
authors: Anita
authors: A
authors: Abedi
authors: Department of Pilot Nanobiotechnology, Pasteur Institute of Iran, Tehran, Iran.
authors: Seyed Ebrahim
authors: SE
authors: Alavi
authors: Department of Pilot Nanobiotechnology, Pasteur Institute of Iran, Tehran, Iran.
authors: Fatemeh
authors: F
authors: Movahedi
authors: Department of Pilot Nanobiotechnology, Pasteur Institute of Iran, Tehran, Iran.
authors: Maedeh
authors: M
authors: Koohi Moftakhari Esfahani
authors: Department of Immunology, Faculty of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran.
authors: Tahereh
authors: T
authors: Zadeh Mehrizi
authors: Department of Pilot Nanobiotechnology, Pasteur Institute of Iran, Tehran, Iran.
authors: Azim
authors: A
authors: Akbarzadeh
keywords: Carboplatinum; Cisplatinum; Drug delivery; Emulsion polymerization; Polybutylcyanoacrylate