title: Peripheral biomarkers of oxidative stress and their limited potential in evaluation of clinical features of Huntington's patients.
abstract: BACKGROUND
  Peripheral oxidative biomarkers could be useful for monitoring clinical features of Huntington's disease (HD).
  
  
  METHODS
  Cu/Zn-superoxide dismutase (Cu/Zn-SOD), neuron-specific enolase (NSE) and 8-hydroxy-2'-deoxyguanosine (8-oxoGua) serum levels were analysed in 18 HD patients and 10 controls. Clinical measures were recorded from each HD patients.
  
  
  RESULTS
  Cu/Zn-SOD, NSE and 8-oxoGua values were higher in HD patients than in controls. Cu/Zn-SOD and NSE correlated positively. No correlation was observed between the biomarkers analysed and the clinical measures assessed.
  
  
  CONCLUSIONS
  Serum oxidative biomarkers could express the neuronal oxidative processes going on in HD patients but are inadequate to evaluate clinical features of the disease.
authors: Department of Medicine, Health, and Environmental Sciences, University of L'Aquila , L'Aquila , Italy .
authors: Irene
authors: I
authors: Ciancarelli
authors: Daniela
authors: D
authors: De Amicis
authors: Caterina
authors: C
authors: Di Massimo
authors: Carla
authors: C
authors: Di Scanno
authors: Caterina
authors: C
authors: Pistarini
authors: Nicolantonio
authors: N
authors: D'Orazio
authors: Maria Giuliana
authors: MG
authors: Tozzi Ciancarelli
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000097:blood; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D010751:Phosphopyruvate Hydratase / Q000097:blood; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D015415:Biomarkers; D000080242:8-Hydroxy-2'-Deoxyguanosine; D013482:Superoxide Dismutase; D010751:Phosphopyruvate Hydratase; D003849:Deoxyguanosine
keywords: Biomarkers; Huntington's disease; neuronal oxidative damage; oxidative stress