title: Lack of association of angiotensin-converting enzyme insertion/deletion polymorphism with breast cancer: An update meta-analysis based on 10405 subjects.
abstract: OBJECTIVE
  Previous case-control studies on the relation between angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and breast cancer did not reach the same conclusion. In the present study, we aimed to further evaluate the relationship between the ACE gene I/D polymorphism and breast cancer.
  
  
  METHODS
  We selected 13 case-control studies related to ACE gene I/D polymorphism and breast cancer by searching PubMed, EMBase, Chinese Biomedical Literature Database, Chinese CNKI, and Wanfang database. To test the heterogeneity between each study, we utilized the Q-test and I(2) test. To merge the odds ratio (OR) and 95% confidence interval (CI), we utilized the random effects model during the analyses.
  
  
  RESULTS
  The present study included 1997 patients with breast cancer and 8404 cancer-free control subjects. By meta-analysis, we did not find any association of ACE gene I/D polymorphism with breast cancer in different model (DD vs (ID+II): OR=1.28, 95% CI (0.90-1.81), p=0.16; II vs (ID+DD): OR=0.99, 95% CI (0.81-1.21), p=0.93; D allele vs I allele: OR=1.15, 95% CI (0.94-1.41), p=0.18).
  
  
  CONCLUSIONS
  We concluded that ACE gene I/D polymorphism was not associated with breast cancer.
authors: Department of Breast Surgery, First People's Hospital of Wenling, P.R. China.
authors: Xiao-Lei
authors: XL
authors: Li
authors: Department of Breast Surgery, First People's Hospital of Wenling, P.R. China.
authors: Zhi-Jian
authors: ZJ
authors: Zheng
authors: Department of Breast Surgery, First People's Hospital of Wenling, P.R. China quhaiou@21cn.com.
authors: Hai-Ou
authors: HO
authors: Qu
mesh_terms: D000483:Alleles; D001943:Breast Neoplasms / Q000201:enzymology* / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D054643:INDEL Mutation / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D017594:Publication Bias; D012307:Risk Factors
chemical_list: C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A
keywords: Breast cancer; angiotensin-converting enzyme; gene polymorphism; meta-analysis