title: Acantholytic squamous cell carcinoma: pathological study of nine cases with review of literature.
abstract: Squamous cell carcinoma (SCC) is classified in many subtypes or forms; one of them is the acantholytic squamous cell carcinoma, also called pseudoglandular, adenoid, epithelioma dyskeratoticum segregans, or adenoacanthoma. Researching and analyzing nine cases of acantholytic squamous cell carcinoma, we intend to verify if the data provided by the cases studied can be validated by the scientific literature. All the cases presented lesions found on the head and neck skin, with two exceptions - one on the larynx and the other one on the tonsil, all of them ulcerated lesions. In two cases, the tumors developed on the skin, in preneoplasic lesions (actinic keratosis). The tumors had dimensions between 4/3/4 mm and 100/90/36 mm. During one year, two of the cases studied presented multiple recurrences. We also found two cases of metatypical carcinoma accompanied the acantholytic variant of squamous cell carcinoma. None of the analyzed cases presented distant metastasis. The histopathological criteria for selection were: keratinised squamous tumor cell type, adenoid structures with round spaces with a defined wall of at least one cell width, spaces with isolated or grouped dyskeratotic acantholytic cells.
authors: Department of Pathology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania; m_costache_dermatopat@yahoo.com.
authors: Maria
authors: M
authors: Sajin
authors: Alina
authors: A
authors: Hodorogea Prisăcaru
authors: Mihaela Cristina
authors: MC
authors: Luchian
authors: Oana Maria
authors: OM
authors: Pătraşcu
authors: Adrian
authors: A
authors: Dumitru
authors: Diana
authors: D
authors: Costache
authors: Doina
authors: D
authors: Dumitrescu
authors: Daniela
authors: D
authors: Vrînceanu
authors: Liliana Mary
authors: LM
authors: Voinea
authors: Olga
authors: O
authors: Simionescu
authors: Mariana
authors: M
authors: Costache
mesh_terms: D000051:Acantholysis / Q000150:complications / Q000473:pathology*; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000473:pathology*; D005142:Eyelid Neoplasms / Q000150:complications / Q000473:pathology; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000150:complications / Q000473:pathology; D008048:Lip Neoplasms / Q000150:complications / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000150:complications / Q000473:pathology; D012878:Skin Neoplasms / Q000150:complications / Q000473:pathology*; D014067:Tonsillar Neoplasms / Q000150:complications / Q000473:pathology