title: Effect of thoracic epidural anaesthesia on serum vascular endothelial growth factor C and cytokines in patients undergoing anaesthesia and surgery for colon cancer.
abstract: BACKGROUND
  Serum vascular endothelial growth factor-C (VEGF-C), transforming growth factor-β (TGF-β), and interleukin (IL)-6 promote angiogenesis and metastases in colon cancer. We hypothesized that patients who received propofol-epidural anaesthesia (PEA) would exhibit decreases in VEGF-C, TGF-β, and IL-6 and an increase in IL-10 compared with patients who received general anaesthesia (GA).
  
  
  METHODS
  Colon cancer surgery patients were randomly assigned to the PEA (n=20) or GA (n=20) group. Serum VEGF-C, TGF-β, IL-6, and IL-10 levels before surgery and 24 h after surgery were measured.
  
  
  RESULTS
  Patients who received PEA showed decreases in VEGF-C [526 (261) vs 834 (304) pg ml(-1), P=0.001], TGF-β (P=0.027), and IL-6 (P=0.007) and an increase in IL-10 (P=0.001) 24 h after surgery compared with patients subjected to GA. The visual analogue scale scores at rest and during coughing at 2 and 24 h after operation were significantly lower in PEA patients (P<0.05).
  
  
  CONCLUSIONS
  PEA reduces serum concentrations of factors associated with angiogenesis during colon cancer surgery.
  
  
  BACKGROUND
  ChiCTR-TRC-13003146 (www.chictr.org).
authors: Department of Anaesthesiology, Fudan University Shanghai Cancer Center, No.270 Dong-an Road, Shanghai 200032, P.R. China Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, P.R. China.
authors: Y J
authors: YJ
authors: Xu
authors: Department of Anaesthesiology, Fudan University Shanghai Cancer Center, No.270 Dong-an Road, Shanghai 200032, P.R. China Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, P.R. China.
authors: W K
authors: WK
authors: Chen
authors: Department of Anaesthesiology, Fudan University Shanghai Cancer Center, No.270 Dong-an Road, Shanghai 200032, P.R. China Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, P.R. China.
authors: Y
authors: Y
authors: Zhu
authors: Department of Anaesthesiology, Fudan University Shanghai Cancer Center, No.270 Dong-an Road, Shanghai 200032, P.R. China Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, P.R. China.
authors: S L
authors: SL
authors: Wang
authors: Department of Anaesthesiology, Fudan University Shanghai Cancer Center, No.270 Dong-an Road, Shanghai 200032, P.R. China Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, P.R. China miaochh@aliyun.com.
authors: C H
authors: CH
authors: Miao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000767:Anesthesia, Epidural / Q000379:methods*; D000768:Anesthesia, General; D018686:Anesthetics, Intravenous / Q000494:pharmacology; D043925:Angiogenesis Inducing Agents / Q000097:blood; D003110:Colonic Neoplasms / Q000473:pathology / Q000601:surgery*; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood; D009367:Neoplasm Staging; D010147:Pain Measurement / Q000379:methods; D010149:Postoperative Pain; D011184:Postoperative Period; D015742:Propofol / Q000494:pharmacology; D011446:Prospective Studies; D013904:Thoracic Vertebrae; D042582:Vascular Endothelial Growth Factor C / Q000097:blood*; D055815:Young Adult
chemical_list: D018686:Anesthetics, Intravenous; D043925:Angiogenesis Inducing Agents; D016207:Cytokines; D009363:Neoplasm Proteins; C467486:VEGFC protein, human; D042582:Vascular Endothelial Growth Factor C; D015742:Propofol
keywords: anaesthesia, general; anaesthetic techniques, epidural; cancer, colorectal; surgery, colorectal