title: Lack of any prognostic relationship between adiponectin receptor (Adipo R1/R2) expression for early/advanced stage gastric cancer.
abstract: BACKGROUND
  Adiponectin (ApN) is a complement C1q-related protein, mainly secreted from adipose tissue, that signals through ApN receptor 1 (Adipo-R1) and ApN receptor 2 (Adipo-R2). Low serum ApN concentrations are associated with obesity-related malignancies. However, there are very few studies on any prognostic role of ApN receptors in gastric cancer.
  
  
  OBJECTIVE
  The aim of this study is to investigate the relationship between AdipoR1/R2 expression and early/advanced stage gastric cancer in terms of clinicopathologic characteristics and survival.
  
  
  METHODS
  Eighteen patients with early and 39 with advanced stage gastric cancer who underwent surgical gastric resection were included in this study.
  
  
  RESULTS
  Adipo-R1 expression was low in 2 of the 18 patients with early stage gastric cancer (11.1%), while 4 had low Adipo-R2 expression (22.2%). In those with advanced stage gastric cancer, 7 of 39 had low Adipo-R1 expression (17.9%) and 16 had low Adipo-R2 expression (41%). Adipo-R2 expression was significantly higher (p=0.011) in moderately differentiated tumors when compared to well-differentiated tumors. While there was nearly a statistically significant relationship between TNM stage (T, tumor size; N, regional lymph node; M, whether distant metastases exist) and Adipo-R2 expression (p=0.054), there was no relationship between Adipo-R1/-R2 expression with tumor stage and survival.
  
  
  CONCLUSIONS
  Adipo-R1/-R2 expression has no prognostic significance of in early/advanced stage gastric cancer.
authors: Department of Gastroenterology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey E-mail : talatayy@gmail.com A.
authors: Talat
authors: T
authors: Ayyildiz
authors: Enver
authors: E
authors: Dolar
authors: Nesrin
authors: N
authors: Ugras
authors: Oguzhan Sitki
authors: OS
authors: Dizdar
authors: Saduman Balaban
authors: SB
authors: Adim
authors: Omer
authors: O
authors: Yerci
mesh_terms: D005260:Female; D015870:Gene Expression / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods; D011379:Prognosis; D054419:Receptors, Adiponectin / Q000235:genetics*; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology*
chemical_list: C475418:ADIPOR1 protein, human; C475420:ADIPOR2 protein, human; D054419:Receptors, Adiponectin