title: Mesenchymal stem cells can modulate longitudinal changes in cortical thickness and its related cognitive decline in patients with multiple system atrophy.
abstract: Multiple system atrophy (MSA) is an adult-onset, sporadic neurodegenerative disease. Because the prognosis of MSA is fatal, neuroprotective or regenerative strategies may be invaluable in MSA treatment. Previously, we obtained clinical and imaging evidence that mesenchymal stem cell (MSC) treatment could have a neuroprotective role in MSA patients. In the present study, we evaluated the effects of MSC therapy on longitudinal changes in subcortical deep gray matter volumes and cortical thickness and their association with cognitive performance. Clinical and imaging data were obtained from our previous randomized trial of autologous MSC in MSA patients. During 1-year follow-up, we assessed longitudinal differences in automatic segmentation-based subcortical deep gray matter volumes and vertex-wise cortical thickness between placebo (n = 15) and MSC groups (n = 11). Next, we performed correlation analysis between the changes in cortical thickness and changes in the Korean version of the Montreal Cognitive Assessment (MoCA) scores and cognitive performance of each cognitive subdomain using a multiple, comparison correction. There were no significant differences in age at baseline, age at disease onset, gender ratio, disease duration, clinical severity, MoCA score, or education level between the groups. The automated subcortical volumetric analysis revealed that the changes in subcortical deep gray matter volumes of the caudate, putamen, and thalamus did not differ significantly between the groups. The areas of cortical thinning over time in the placebo group were more extensive, including the frontal, temporal, and parietal areas, whereas these areas in the MSC group were less extensive. Correlation analysis indicated that declines in MoCA scores and phonemic fluency during the follow-up period were significantly correlated with cortical thinning of the frontal and posterior temporal areas and anterior temporal areas in MSA patients, respectively. In contrast, no significant correlations were observed in the MSC group. These results suggest that MSC treatment in patients with MSA may modulate cortical thinning over time and related cognitive performance, inferring a future therapeutic candidate for cognitive disorders.
authors: Department of Neurology, Bundang Jesaeng General Hospital Seongnam, Korea.
authors: Mun Kyung
authors: MK
authors: Sunwoo
authors: Department of Biomedical Engineering, Hanyang University Seoul, South Korea.
authors: Hyuk Jin
authors: HJ
authors: Yun
authors: Department of Neurology, Jeju University College of Medicine Jeju, Korea.
authors: Sook K
authors: SK
authors: Song
authors: Department of Neurology, Yonsei University College of Medicine Seoul, Korea.
authors: Ji Hyun
authors: JH
authors: Ham
authors: Department of Neurology, Wonju College of Medicine, Yonsei University Wonju, Korea.
authors: Jin Yong
authors: JY
authors: Hong
authors: Department of Neurology, Yonsei University College of Medicine Seoul, Korea.
authors: Ji E
authors: JE
authors: Lee
authors: Department of Biostatistics, Yonsei University College of Medicine Seoul, Korea.
authors: Hye S
authors: HS
authors: Lee
authors: Department of Neurology, Yonsei University College of Medicine Seoul, Korea.
authors: Young H
authors: YH
authors: Sohn
authors: Department of Biomedical Engineering, Hanyang University Seoul, South Korea.
authors: Jong-Min
authors: JM
authors: Lee
authors: Department of Neurology, Yonsei University College of Medicine Seoul, Korea ; Severance Biomedical Science Institute, Yonsei University College of Medicine Seoul Korea.
authors: Phil Hyu
authors: PH
authors: Lee
keywords: clinical trial; cognition; cortical thickness; mesenchymal stem cells; multiple system atrophy