title: Gestational trophoblastic disease in the western region of Saudi Arabia (single-institute experience).
abstract: OBJECTIVE
  To estimate the prevalence of gestational trophoblastic disease (GTD) in the western region of Saudi Arabia, and to evaluate the success of treatment and the effect of age and risk group on survival.
  
  
  METHODS
  Between January 2001 and December 2010, all patients treated for GTD were identified from the King Abdulaziz University Hospital database. Patients with persistent disease were evaluated according to their clinical treatment outcomes.
  
  
  RESULTS
  In total, 122 cases of GTD were identified in the database. Of these, 77 (63%) cases were diagnosed and received initial treatment at the study centre, resulting in an incidence of 1.26 cases per 1000 deliveries. The mean (±standard deviation) age of the study participants was 31.52 ± 10.8 years, mean gestational age at diagnosis was 12.42 ± 3.2 weeks, and mean follow-up for each patient was 24 months. There were 20 cases (26%) of persistent GTD after treatment. The majority of patients with low-risk disease were treated with single-agent methotrexate, with an overall success rate of 83%. The overall 5-year survival rate for all patients was 98%. Using the Wilcoxon (Gehan) test, risk group and age (cut-off 40 years) were not found to be significantly associated with survival (p=0.69).
  
  
  CONCLUSIONS
  This single-institute study reports the first survival data for GTD for Saudi Arabia. However, the overall incidence of GTD in Saudi Arabia will be defined by establishment of a GTD registry.
authors: Scientific chair of prof. Abdullah Hussain Basalamah for Gynecological Cancer, Faculty of Medicine, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.
authors: Nisrin
authors: N
authors: Anfinan
authors: Scientific chair of prof. Abdullah Hussain Basalamah for Gynecological Cancer, Faculty of Medicine, King Abdulaziz University Hospital, Jeddah, Saudi Arabia. Electronic address: khalidsait@yahoo.com.
authors: Khalid
authors: K
authors: Sait
authors: Scientific chair of prof. Abdullah Hussain Basalamah for Gynecological Cancer, Faculty of Medicine, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.
authors: Hesham
authors: H
authors: Sait
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002822:Choriocarcinoma / Q000188:drug therapy / Q000453:epidemiology / Q000556:secondary; D003609:Dactinomycin / Q000627:therapeutic use; D005260:Female; D031901:Gestational Trophoblastic Disease / Q000188:drug therapy / Q000453:epidemiology* / Q000556:secondary; D006801:Humans; D006828:Hydatidiform Mole / Q000188:drug therapy / Q000453:epidemiology / Q000556:secondary; D008175:Lung Neoplasms / Q000188:drug therapy / Q000453:epidemiology / Q000556:secondary; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D011247:Pregnancy; D015995:Prevalence; D011379:Prognosis; D012529:Saudi Arabia / Q000453:epidemiology; D014594:Uterine Neoplasms / Q000188:drug therapy / Q000453:epidemiology* / Q000473:pathology; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D003609:Dactinomycin; D008727:Methotrexate
keywords: Incidence; Survival rate; Trophoblastic disease