title: Borrelia miyamotoi sensu lato seroreactivity and seroprevalence in the northeastern United States.
abstract: Borrelia miyamotoi sensu lato, a relapsing fever Borrelia sp., is transmitted by the same ticks that transmit B. burgdorferi (the Lyme disease pathogen) and occurs in all Lyme disease-endemic areas of the United States. To determine the seroprevalence of IgG against B. miyamotoi sensu lato in the northeastern United States and assess whether serum from B. miyamotoi sensu lato-infected persons is reactive to B. burgdorferi antigens, we tested archived serum samples from area residents during 1991-2012. Of 639 samples from healthy persons, 25 were positive for B. miyamotoi sensu lato and 60 for B. burgdorferi. Samples from ≈10% of B. miyamotoi sensu lato-seropositive persons without a recent history of Lyme disease were seropositive for B. burgdorferi. Our results suggest that human B. miyamotoi sensu lato infection may be common in southern New England and that B. burgdorferi antibody testing is not an effective surrogate for detecting B. miyamotoi sensu lato infection.
authors: Peter J
authors: PJ
authors: Krause
authors: Sukanya
authors: S
authors: Narasimhan
authors: Gary P
authors: GP
authors: Wormser
authors: Alan G
authors: AG
authors: Barbour
authors: Alexander E
authors: AE
authors: Platonov
authors: Janna
authors: J
authors: Brancato
authors: Timothy
authors: T
authors: Lepore
authors: Kenneth
authors: K
authors: Dardick
authors: Mark
authors: M
authors: Mamula
authors: Lindsay
authors: L
authors: Rollend
authors: Tanner K
authors: TK
authors: Steeves
authors: Maria
authors: M
authors: Diuk-Wasser
authors: Sahar
authors: S
authors: Usmani-Brown
authors: Phillip
authors: P
authors: Williamson
authors: Denis S
authors: DS
authors: Sarksyan
authors: Erol
authors: E
authors: Fikrig
authors: Durland
authors: D
authors: Fish
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood / Q000276:immunology; D001898:Borrelia / Q000276:immunology*; D001899:Borrelia Infections / Q000097:blood / Q000453:epidemiology* / Q000276:immunology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D008193:Lyme Disease / Q000097:blood / Q000453:epidemiology / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009511:New England / Q000453:epidemiology; D016036:Seroepidemiologic Studies
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G
keywords: Borrelia burgdorferi; Borrelia miyamotoi infection; Borrelia miyamotoi sensu lato; Lyme disease; New England; New York State; United States; bacteria; northeastern United States; relapsing fever; seroprevalence; seroreactivity; spirochete; tick-borne disease; ticks