title: A randomized controlled trial of the effects of aerobic dance training on blood lipids among individuals with hypertension on a thiazide.
abstract: OBJECTIVE
  Hypertension is associated with dyslipidemia. Thiazides adversely affect serum lipid levels in hypertensives. There is currently a dearth of information on benefits of aerobic exercise training on serum lipid levels in individuals on thiazides and this study aimed at bridging this gap in knowledge.
  
  
  METHODS
  This randomized-controlled trial involved 120 newly-diagnosed adults with essential hypertension (≥65 years). They were treated with 50 mg of hydrochlorothiazide + 5 mg of hydrochloride amiloride and 5 or 10 mg of amlodipine for 4-6 weeks before they were randomly assigned into exercise group (EG) and control croup (CG). Only EG underwent 12-week aerobic dance training at 50-70 % of heart rate reserve three times per week. Low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol, triglyceride and total cholesterol were measured and recorded at baseline and post-study.
  
  
  RESULTS
  Eighty-eight (45 in EG and 43 in CG) of 120 participants randomly assigned to groups completed the study. Systolic (p = 0.370) and diastolic (p = 0.771) blood pressures (BP) were similar between the two groups at baseline. Systolic (p < 0.001) and diastolic (p < 0.001) BPs reduced significantly in exercise and control groups. LDL-C (from 120.10 ± 33.41 to 110.50 ± 31.68 mg/dl; p = 0.037) and triglyceride (from 117.49 ± 45.12 to 100.63 ± 35.42 mg/dl; p = 0.002) decreased in EG post-study but no significant between-group differences were observed.
  
  
  CONCLUSIONS
  Although, LDL-C and triglyceride are reduced after aerobic dance training, they were not any more than without it. Aerobic dance training has favorable effects on LDL-C, triglyceride, and systolic and diastolic BP in individuals with hypertension on a thiazide.
authors: Department of Medical Rehabilitation, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Nigeria, mafaad@yahoo.com.
authors: Fatai A
authors: FA
authors: Maruf
authors: Aderonke O
authors: AO
authors: Akinpelu
authors: Babatunde L
authors: BL
authors: Salako
mesh_terms: D000368:Aged; D000584:Amiloride / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003615:Dancing / Q000502:physiology*; D004359:Drug Therapy, Combination; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use*; D006973:Hypertension / Q000097:blood* / Q000628:therapy*; D008055:Lipids / Q000097:blood*; D008297:Male; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D008055:Lipids; D006852:Hydrochlorothiazide; D000584:Amiloride