title: Brachial-ankle pulse wave velocity for predicting functional outcome in acute stroke.
abstract: OBJECTIVE
  We investigated whether the brachial-ankle pulse wave velocity (baPWV) has prognostic value for predicting functional outcome after acute cerebral infarction and whether the prognostic value differs between stroke subtypes.
  
  
  METHODS
  We included 1091 consecutive patients with first-ever acute cerebral infarction who underwent baPWV measurements. Stroke subtypes were classified using the Trial of Org 10172 in Acute Stroke Treatment classification. Poor functional outcomes were defined as modified Rankin Scale score >2 at 3 months after stroke onset.
  
  
  RESULTS
  We noted that 181 (16.59%) patients had a poor functional outcome. In multivariate logistic regression, patients in the highest tertile of baPWV (>22.25 m/s) were found to be at increased risk for poor functional outcome (adjusted odds ratio, 1.88; 95% confidence interval, 1.06-3.40) compared with those in the lowest tertile (<17.55 m/s). No significant interaction between baPWV and stroke subtype was noted. Receiver operating characteristic curve analysis indicated that the addition of baPWV to the prediction model significantly improved the discrimination ability for poor functional outcome.
  
  
  CONCLUSIONS
  baPWV has an independent prognostic value for predicting functional outcome after acute cerebral infarction. The prognostic value did not differ according to the stroke subtype.
authors: From the Department of Neurology, CHA Bundang Medical Center, CHA University, Seongnam, Gyeonggi-do, Korea (J.K.); Department of Neurology, Ewha Womans University, Seoul, Korea (T.-J.S.); and Departments of Neurology (J.K., E.H.K., K.J.L., D.S., H.S.N., Y.D.K., J.H.H.) and Biostatistics (H.S.L., C.M.N.), Yonsei University College of Medicine, Seoul, Korea.
authors: Jinkwon
authors: J
authors: Kim
authors: From the Department of Neurology, CHA Bundang Medical Center, CHA University, Seongnam, Gyeonggi-do, Korea (J.K.); Department of Neurology, Ewha Womans University, Seoul, Korea (T.-J.S.); and Departments of Neurology (J.K., E.H.K., K.J.L., D.S., H.S.N., Y.D.K., J.H.H.) and Biostatistics (H.S.L., C.M.N.), Yonsei University College of Medicine, Seoul, Korea.
authors: Tae-Jin
authors: TJ
authors: Song
authors: From the Department of Neurology, CHA Bundang Medical Center, CHA University, Seongnam, Gyeonggi-do, Korea (J.K.); Department of Neurology, Ewha Womans University, Seoul, Korea (T.-J.S.); and Departments of Neurology (J.K., E.H.K., K.J.L., D.S., H.S.N., Y.D.K., J.H.H.) and Biostatistics (H.S.L., C.M.N.), Yonsei University College of Medicine, Seoul, Korea.
authors: Eun Hye
authors: EH
authors: Kim
authors: From the Department of Neurology, CHA Bundang Medical Center, CHA University, Seongnam, Gyeonggi-do, Korea (J.K.); Department of Neurology, Ewha Womans University, Seoul, Korea (T.-J.S.); and Departments of Neurology (J.K., E.H.K., K.J.L., D.S., H.S.N., Y.D.K., J.H.H.) and Biostatistics (H.S.L., C.M.N.), Yonsei University College of Medicine, Seoul, Korea.
authors: Ki Jeong
authors: KJ
authors: Lee
authors: From the Department of Neurology, CHA Bundang Medical Center, CHA University, Seongnam, Gyeonggi-do, Korea (J.K.); Department of Neurology, Ewha Womans University, Seoul, Korea (T.-J.S.); and Departments of Neurology (J.K., E.H.K., K.J.L., D.S., H.S.N., Y.D.K., J.H.H.) and Biostatistics (H.S.L., C.M.N.), Yonsei University College of Medicine, Seoul, Korea.
authors: Hye Sun
authors: HS
authors: Lee
authors: From the Department of Neurology, CHA Bundang Medical Center, CHA University, Seongnam, Gyeonggi-do, Korea (J.K.); Department of Neurology, Ewha Womans University, Seoul, Korea (T.-J.S.); and Departments of Neurology (J.K., E.H.K., K.J.L., D.S., H.S.N., Y.D.K., J.H.H.) and Biostatistics (H.S.L., C.M.N.), Yonsei University College of Medicine, Seoul, Korea.
authors: Chung Mo
authors: CM
authors: Nam
authors: From the Department of Neurology, CHA Bundang Medical Center, CHA University, Seongnam, Gyeonggi-do, Korea (J.K.); Department of Neurology, Ewha Womans University, Seoul, Korea (T.-J.S.); and Departments of Neurology (J.K., E.H.K., K.J.L., D.S., H.S.N., Y.D.K., J.H.H.) and Biostatistics (H.S.L., C.M.N.), Yonsei University College of Medicine, Seoul, Korea.
authors: Dongbeom
authors: D
authors: Song
authors: From the Department of Neurology, CHA Bundang Medical Center, CHA University, Seongnam, Gyeonggi-do, Korea (J.K.); Department of Neurology, Ewha Womans University, Seoul, Korea (T.-J.S.); and Departments of Neurology (J.K., E.H.K., K.J.L., D.S., H.S.N., Y.D.K., J.H.H.) and Biostatistics (H.S.L., C.M.N.), Yonsei University College of Medicine, Seoul, Korea.
authors: Hyo Suk
authors: HS
authors: Nam
authors: From the Department of Neurology, CHA Bundang Medical Center, CHA University, Seongnam, Gyeonggi-do, Korea (J.K.); Department of Neurology, Ewha Womans University, Seoul, Korea (T.-J.S.); and Departments of Neurology (J.K., E.H.K., K.J.L., D.S., H.S.N., Y.D.K., J.H.H.) and Biostatistics (H.S.L., C.M.N.), Yonsei University College of Medicine, Seoul, Korea.
authors: Young Dae
authors: YD
authors: Kim
authors: From the Department of Neurology, CHA Bundang Medical Center, CHA University, Seongnam, Gyeonggi-do, Korea (J.K.); Department of Neurology, Ewha Womans University, Seoul, Korea (T.-J.S.); and Departments of Neurology (J.K., E.H.K., K.J.L., D.S., H.S.N., Y.D.K., J.H.H.) and Biostatistics (H.S.L., C.M.N.), Yonsei University College of Medicine, Seoul, Korea. jhheo@yuhs.ac.
authors: Ji Hoe
authors: JH
authors: Heo
mesh_terms: D000368:Aged; D055109:Ankle Brachial Index; D001783:Blood Flow Velocity / Q000502:physiology*; D001916:Brachial Artery / Q000503:physiopathology*; D002545:Brain Ischemia / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D063177:Pulse Wave Analysis; D012189:Retrospective Studies; D020521:Stroke / Q000188:drug therapy / Q000503:physiopathology*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator
keywords: prognosis; pulse wave analysis; stroke