title: Lipophilicity - beyond octanol/water: a short comparison of modern technologies.
abstract: Sorting out new chemical entities (NCE) with inappropriate absorption, distribution, metabolism, excretion (ADME) behaviour at an early stage of drug discovery and development is a major challenge in pharmaceutical profiling. An accepted strategy to predict absorption is the measurement of the permeability of a drug candidate. One step earlier the lipophilicity of a compound is determined, which is directly related to permeability and fraction absorbed. Here, we compare today's state of the art technologies for a fast measurement of lipophilicity.:
authors: NIMBUS Biotechnologie GmbH, Eilenburger Str. 4, 04317 Leipzig, Germany. Electronic address:thorsten.hartmann@nimbus-biotech.com.
authors: Thorsten
authors: T
authors: Hartmann
authors: NIMBUS Biotechnologie GmbH, Eilenburger Str. 4, 04317 Leipzig, Germany.
authors: Johannes
authors: J
authors: Schmitt