title: Multivalent anchoring and cross-linking of mussel-inspired antifouling surface coatings.
abstract: In this work, we combine nature's amazing bioadhesive catechol with the excellent bioinert synthetic macromolecule hyperbranched polyglycerol (hPG) to prepare antifouling surfaces. hPG can be functionalized by different amounts of catechol groups for multivalent anchoring and cross-linking because of its highly branched architecture. The catecholic hPGs can be immobilized on various surfaces including metal oxides, noble metals, ceramics, and polymers via simple incubation procedures. The effect of the catechol amount on the immobilization, surface morphology, stability, and antifouling performance of the coatings was studied. Both anchoring and cross-linking interactions provided by catechols can enhance the stability of the coatings. When the catechol groups on the hPG are underrepresented, the tethering of the coating is not effective; while an overrepresentation of catechol groups leads to protein adsorption and cell adhesion. Thus, only a well-balanced amount of catechols as optimized and described in this work can supply the coatings with both good stability and antifouling ability.
authors: Multifunctional Biomaterials for Medicine, Helmholtz Virtual Institute , Kantstr. 55, 14513 Teltow-Seehof, Germany.
authors: Qiang
authors: Q
authors: Wei
authors: Tobias
authors: T
authors: Becherer
authors: Radu-Cristian
authors: RC
authors: Mutihac
authors: Paul-Ludwig Michael
authors: PL
authors: Noeske
authors: Florian
authors: F
authors: Paulus
authors: Rainer
authors: R
authors: Haag
authors: Ingo
authors: I
authors: Grunwald
mesh_terms: D000327:Adsorption; D000818:Animals; D057219:Biofouling / Q000517:prevention & control*; D049872:Bivalvia / Q000737:chemistry*; D002396:Catechols; D002448:Cell Adhesion; D002460:Cell Line; D002516:Ceramics / Q000737:chemistry; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism; D005990:Glycerol / Q000737:chemistry; D051379:Mice; D018625:Microscopy, Atomic Force; D041681:NIH 3T3 Cells; D010087:Oxides / Q000737:chemistry; D056951:Photoelectron Spectroscopy; D011108:Polymers / Q000737:chemistry; D011506:Proteins / Q000737:chemistry; D013499:Surface Properties
chemical_list: D002396:Catechols; D020099:Coated Materials, Biocompatible; D010087:Oxides; D011108:Polymers; D011506:Proteins; C043941:polyglycerol; C034221:catechol; D005990:Glycerol