title: Preventive effect of a high fluoride toothpaste and arginine-carbonate toothpaste on dentinal tubules exposure followed by acid challenge: a dentine permeability evaluation.
abstract: BACKGROUND
  Considering the current high use of high fluoride toothpastes, the aim of the study was to quantify alterations in the root dentine permeability submitted to treatment with a high fluoride toothpaste and 8% arginine, calcium carbonate, sodium monofluorophosphate toothpaste as a preventive treatment for dentinal tubules exposure followed by acid challenge.
  
  
  METHODS
  Thirty-third molars were sectioned below the cementoenamel. The root segments were connected to a hydraulic pressure apparatus to measure dentine permeability after the following sequential steps (n = 10 per group): I) Baseline; II) treatment with phosphoric acid for 30 s (maximum permeability); III) Toothbrushing (1 min) according to the experimental groups (G1- control; G2- 5000 ppm fluoride toothpaste; G3- 8% arginine-calcium carbonate toothpaste); IV) acid challenge for 5 min (orange juice). The data were converted into percentage, considering stage II as 100%.
  
  
  RESULTS
  The results have shown a statistically significant decreasing on dentine permeability after treatment with toothpaste (Friedman test and Dunn's post hoc test). Comparison among groups demonstrated a high increasing on dentine permeability when acid challenge was performed after toothbrushing with distilled water (control group) (Kruskal-Wallis and Dunn's post hoc test).
  
  
  CONCLUSIONS
  The toothpaste treatment may provide sufficient resistance on dentine surface, preventing dentinal tubules exposure after acid challenge.
authors: Shelon Cristina Souza
authors: SC
authors: Pinto
authors: Department of Post-Graduate Program in Dentistry, CEUMA University, Sao Luis, MA, Brazil. mbandeca@gmail.com.
authors: Matheus Coelho
authors: MC
authors: Bandéca
authors: Michele Carolina
authors: MC
authors: Pinheiro
authors: Rodrigo
authors: R
authors: Cavassim
authors: Mateus Rodrigues
authors: MR
authors: Tonetto
authors: Alvaro Henrique
authors: AH
authors: Borges
authors: José Eduardo Cezar
authors: JE
authors: Sampaio
mesh_terms: D000293:Adolescent; D001120:Arginine / Q000494:pharmacology*; D001628:Beverages; D002119:Calcium Carbonate / Q000494:pharmacology*; D032084:Citrus sinensis / Q000737:chemistry; D003804:Dentin / Q000187:drug effects*; D005459:Fluorides / Q000494:pharmacology*; D006801:Humans; D008963:Molar / Q000737:chemistry / Q000187:drug effects; D010477:Perfusion; D010539:Permeability / Q000187:drug effects; D010710:Phosphates / Q000494:pharmacology*; D010756:Phosphoric Acids / Q000494:pharmacology*; D012969:Sodium Fluoride / Q000494:pharmacology*; D046509:Tissue Culture Techniques; D014081:Tooth Extraction; D014099:Toothbrushing; D014100:Toothpastes / Q000737:chemistry; D055815:Young Adult
chemical_list: D010710:Phosphates; D010756:Phosphoric Acids; D014100:Toothpastes; C012980:fluorophosphate; D012969:Sodium Fluoride; D001120:Arginine; C030242:phosphoric acid; D002119:Calcium Carbonate; D005459:Fluorides