title: A cooperative Pd-Cu system for direct C-H bond arylation.
abstract: A novel and efficient method for C-H arylation using well-defined Pd- and Cu-NHC systems has been developed. This process promotes the challenging construction of C-C bonds from arenes or heteroarenes using aryl bromides and chlorides. Mechanistic studies show that [Cu(OH)(NHC)] plays a key role in the C-H activation and is involved in the transmetallation with the Pd-NHC co-catalyst.
authors: EaStCHEM School of Chemistry, University of St Andrews, St Andrews, KY16 9ST, UK. cc111@st-andrews.ac.uk.
authors: Mathieu
authors: M
authors: Lesieur
authors: Faïma
authors: F
authors: Lazreg
authors: Catherine S J
authors: CS
authors: Cazin
mesh_terms: D001965:Bromides / Q000737:chemistry; D002384:Catalysis; D002712:Chlorides / Q000737:chemistry; D003300:Copper / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D001965:Bromides; D002712:Chlorides; D009942:Organometallic Compounds; D010165:Palladium; D003300:Copper