title: Synthesis and evaluation of a molecularly imprinted polymer for selective solid-phase extraction of irinotecan from human serum samples.
abstract: A molecularly imprinted polymer (MIP) was synthesized by non-covalent imprinting polymerization using irinotecan as template. Methacrylic acid and 4-vinylpyridine were selected as functional monomers. An optimized procedure coupled to LC-PDA analysis was developed for the selective solid-phase extraction of irinotecan from various organic media. A specific capacity of 0.65 µmol•g-1 for the MIP was determined. The high specificity of this MIP was demonstrated by studying the retention behaviour of two related compounds, camptothecin and SN-38. This support was applied for the extraction of irinotecan from human serum samples.
authors: Institut des Biomolécules Max Mousseron, Université Montpellier 2, UMR 5247 CNRS-UM1-UM2, case courrier 1705, Place Eugène Bataillon, Montpellier Cedex 05 F-34095, France. beatrice.roy@univ-montp2.fr.
authors: Béatrice
authors: B
authors: Roy
authors: Institut des Biomolécules Max Mousseron, Université Montpellier 2, UMR 5247 CNRS-UM1-UM2, case courrier 1705, Place Eugène Bataillon, Montpellier Cedex 05 F-34095, France. sung.voduy@yahoo.fr.
authors: Sung
authors: S
authors: Vo Duy
authors: Institut des Biomolécules Max Mousseron, Université Montpellier 2, UMR 5247 CNRS-UM1-UM2, case courrier 1705, Place Eugène Bataillon, Montpellier Cedex 05 F-34095, France. jean-yves.puy@univ-montp2.fr.
authors: Jean-Yves
authors: JY
authors: Puy
authors: Institut des Biomolécules Max Mousseron, Université Montpellier 2, UMR 5247 CNRS-UM1-UM2, case courrier 1705, Place Eugène Bataillon, Montpellier Cedex 05 F-34095, France. charlotte.martin@univ-montp2.fr.
authors: Charlotte
authors: C
authors: Martin
authors: Laboratoire de Ciblage Thérapeutique en Cancérologie, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre Bénite F-69495, France. jerome.guitton@univ-lyon1.fr.
authors: Jérome
authors: J
authors: Guitton
authors: Laboratoire de Cytologie Analytique, Inserm U590, Université Lyon 1, Lyon F-69008, France. charles.dumontet@chu-lyon.fr.
authors: Charles
authors: C
authors: Dumontet
authors: Institut des Biomolécules Max Mousseron, Université Montpellier 2, UMR 5247 CNRS-UM1-UM2, case courrier 1705, Place Eugène Bataillon, Montpellier Cedex 05 F-34095, France. christian.perigaud@univ-montp2.fr.
authors: Christian
authors: C
authors: Périgaud
authors: Institut des Biomolécules Max Mousseron, Université Montpellier 2, UMR 5247 CNRS-UM1-UM2, case courrier 1705, Place Eugène Bataillon, Montpellier Cedex 05 F-34095, France. tournier@univ-montp2.fr.
authors: Isabelle
authors: I
authors: Lefebvre-Tournier