title: Age-specific prevalence of human papilloma virus infection among Nigerian women.
abstract: BACKGROUND
  Inconsistent trends in HPV prevalence by age have been described in Africa. We examined the age prevalence pattern and distribution of 37 HPV-DNA types among urban Nigerian women.
  
  
  METHODS
  The study population was a sample of 278 women who presented to cervical cancer screening programs in Abuja, Nigeria, between April and August 2012. Using a nurse administered questionnaire, information on demographic characteristics and risk factors of cervical cancer was collected and samples of cervical exfoliated cells were obtained from all participants. Roche Linear Array HPV Genotyping Test® was used to characterize prevalent HPV and log-binomial regression models were used to examine the association between potential correlates and the prevalence of HPV infection.
  
  
  RESULTS
  The mean age (SD) of the women enrolled was 38 (8) years. The overall prevalence of HPV was 37%. HPV 35 was the most prevalent HPV type in the study population. Among women age ≤ 30 years, 52% had HPV infection compared to 23% of those women who were older than 45 years (p = 0.006). We observed a significant linear association between age and the prevalence of HPV infections. The prevalence ratio (PR) and 95% confidence interval (CI) was 2.26 (1.17, 4.34) for any HPV infection, 3.83 (1.23, 11.94) for Group 1 HPV (definite carcinogens), and 2.19 (0.99, 4.84) for Group 2a or 2b HPV (probable or possible carcinogens) types, among women aged 18-30 years, compared to women who were older than 45 years.
  
  
  CONCLUSIONS
  The prevalence of HPV infection was highest among younger women and decreased steadily with age among this population of urban Nigerian women.
authors: Department of Nutrition, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA. sna094@mail.harvard.edu.
authors: Sally N
authors: SN
authors: Akarolo-Anthony
authors: Ayo O
authors: AO
authors: Famooto
authors: Eileen O
authors: EO
authors: Dareng
authors: Olayinka B
authors: OB
authors: Olaniyan
authors: Richard
authors: R
authors: Offiong
authors: Cosette M
authors: CM
authors: Wheeler
authors: Clement A
authors: CA
authors: Adebamowo
mesh_terms: D000293:Adolescent; D000328:Adult; D000349:Africa; D000367:Age Factors; D055088:Early Detection of Cancer; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D009549:Nigeria / Q000453:epidemiology; D027383:Papillomaviridae / Q000235:genetics; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology; D015995:Prevalence; D012307:Risk Factors; D011795:Surveys and Questionnaires; D002583:Uterine Cervical Neoplasms / Q000821:virology*; D055815:Young Adult