title: Low SOX17 expression: prognostic significance in de novo acute myeloid leukemia with normal cytogenetics.
abstract: BACKGROUND
  Aberrant expression of SRY-box containing gene 17 (SOX17) has been observed in several solid tumors. However, little is known about SOX17 expression in acute myeloid leukemia (AML). The purpose of this study was to investigate the alteration of SOX17 expression and to explore its clinical significance in AML.
  
  
  METHODS
  Real-time quantitative PCR (RQ-PCR) was performed to analyze the status of SO1X17 expression in 103 patients with de novo AML and 26 normal controls. The clinical relevance of SOX17 expression was analyzed in AML.
  
  
  RESULTS
  SOX17 level in AML was significantly down-regulated compared to controls (p<0.001). Receiver operating characteristic curve (ROC) curve analysis revealed that an area under the ROC curve (AUC) of 0.834 (95% CI 0.765-0.903; p<0.0001) or 0.789 (95% CI 0.690-0.888, p<0.001) in discriminating all patients or cytogenetically normal patients from controls, respectively. The cohort of AML patients was divided into two groups according to the cut-off value of 0.017 (60% sensitivity and 100% specificity, respectively). Cytogenetically normal patients with low SOX17 expression had significantly shorter OS than those with high SOX17 expression (median 4 vs. 25 months, respectively, p=0.035). Multivariate analysis confirmed low SOX17 expression as an independent risk factor.
  
  
  CONCLUSIONS
  Our findings indicated that low SOX17 level may define an important risk factor in AML with normal cyotgenetics.
authors: Chun-Yan
authors: CY
authors: Tang
authors: Jiang
authors: J
authors: Lin
authors: Wei
authors: W
authors: Qian
authors: Jing
authors: J
authors: Yang
authors: Ji-Chun
authors: JC
authors: Ma
authors: Zhao-Qun
authors: ZQ
authors: Deng
authors: Lei
authors: L
authors: Yang
authors: Cui
authors: C
authors: An
authors: Xiang-Mei
authors: XM
authors: Wen
authors: Ying-Ying
authors: YY
authors: Zhang
authors: Jun
authors: J
authors: Qian
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D045744:Cell Line, Tumor; D015331:Cohort Studies; D015536:Down-Regulation; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012333:RNA, Messenger / Q000378:metabolism; D012372:ROC Curve; D012307:Risk Factors; D055760:SOXF Transcription Factors / Q000235:genetics / Q000378:metabolism*; D015996:Survival Rate; D055815:Young Adult
chemical_list: D012333:RNA, Messenger; C109188:SOX17 protein, human; D055760:SOXF Transcription Factors