title: Evaluating the effects and safety of intravenous lipid emulsion on haloperidol-induced neurotoxicity in rabbit.
abstract: There are many reports on the effect of intravenous lipid emulsion (ILE) as an antidote in drugs related toxicities. We determined the effects of ILE on neurotoxicity of haloperidol (HA), a highly lipophilic antipsychotic, as a model of antipsychotics poisoning. We used six groups of five male rabbits. Two groups received distilled water intravenously followed by infusions of either 18 mL/kg of normal saline or ILE 20%, after 30 minutes. The third group received 18 mL/kg of normal saline after HA (2.6 mg/kg) administration. The three other groups received ILE 20% solution (6, 12, and 18 mL/kg) following HA injection. Catalepsy scores, temperature, pupil size, and mortality rate were measured at 0, 0.5, 1, 2, 3, 4, 8, and 24 hours after HA administration began. Blood and tissue samples were taken from all animals at 24 hours or at death time for biochemical, cell count, and pathological studies. ILE reversed cataleptic scores, miotic pupils, and hypothermia of HA intoxication much faster than normal saline (P < 0.001). Biochemical complications and mortality rate of the animals were significantly higher in the HA + 18 mL/Kg ILE group. ILE reversed sings of HA neurotoxicity; however, synergistic effect of high dose of ILE and HA increased complications and mortality.
authors: Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Mohammad
authors: M
authors: Moshiri
authors: Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Amir Hooshang
authors: AH
authors: Mohammadpour
authors: Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran ; Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Maryam
authors: M
authors: Vahabzadeh
authors: Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Leila
authors: L
authors: Etemad
authors: Department of Pathology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Bahram
authors: B
authors: Memar
authors: Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, P.O. Box 91775 1365, Mashhad, Iran.
authors: Hossein
authors: H
authors: Hosseinzadeh
mesh_terms: D000818:Animals; D001831:Body Temperature; D002375:Catalepsy; D005217:Fat Emulsions, Intravenous / Q000009:adverse effects*; D006220:Haloperidol / Q000009:adverse effects*; D020287:In Situ Nick-End Labeling; D007958:Leukocyte Count; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008297:Male; D020258:Neurotoxicity Syndromes / Q000097:blood / Q000473:pathology*; D011680:Pupil; D011817:Rabbits; D016019:Survival Analysis
chemical_list: D005217:Fat Emulsions, Intravenous; D006220:Haloperidol