title: CXC and CC chemokines as angiogenic modulators in nonhaematological tumors.
abstract: Chemokines are a superfamily of structurally homologous heparin-binding proteins that includes potent inducers and inhibitors of angiogenesis. The imbalance between angiogenic and angiostatic chemokine activities can lead to abnormalities, such as chronic inflammation, dysplastic transformation, and even tumor development and spreading. In this review, we summarize the current literature regarding the role of chemokines as modulators of tumor angiogenesis and their potential role as therapeutic targets in patients with nonhaematological tumors.
authors: Clinica di Oncologia Medica, AOU "Ospedali Riuniti ," Università Politecnica delle Marche, Via Conca, 60020 Ancona, Italy.
authors: Matteo
authors: 0000-0001-7340-6173
authors: M
authors: Santoni
authors: UOC Medical Oncology, Department of Oncology, AUSL8, 52100 Arezzo, Italy.
authors: Sergio
authors: S
authors: Bracarda
authors: School of Pharmacy, Section of Experimental Medicine, University of Camerino, 62032 Camerino, Italy.
authors: Massimo
authors: M
authors: Nabissi
authors: Medical Oncology, Azienda Ospedaliera Universitaria Integrata, University of Verona, Piazzale L.A. Scuro 10, 37124 Verona, Italy.
authors: Francesco
authors: F
authors: Massari
authors: Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche, Clinica di Urologia, AOU Ospedali Riuniti, Università Politecnica delle Marche, Via Conca 71, 60126 Ancona, Italy.
authors: Alessandro
authors: 0000-0002-7322-9880
authors: A
authors: Conti
authors: Medical Oncology, Azienda Ospedaliera Universitaria Integrata, University of Verona, Piazzale L.A. Scuro 10, 37124 Verona, Italy.
authors: Emilio
authors: E
authors: Bria
authors: Medical Oncology, Azienda Ospedaliera Universitaria Integrata, University of Verona, Piazzale L.A. Scuro 10, 37124 Verona, Italy.
authors: Giampaolo
authors: G
authors: Tortora
authors: School of Pharmacy, Section of Experimental Medicine, University of Camerino, 62032 Camerino, Italy.
authors: Giorgio
authors: G
authors: Santoni
authors: Clinica di Oncologia Medica, AOU "Ospedali Riuniti ," Università Politecnica delle Marche, Via Conca, 60020 Ancona, Italy.
authors: Stefano
authors: S
authors: Cascinu
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000473:pathology; D019742:Chemokines, CC / Q000378:metabolism*; D019743:Chemokines, CXC / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000098:blood supply* / Q000378:metabolism*; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D019707:Receptors, Chemokine / Q000378:metabolism
chemical_list: D019742:Chemokines, CC; D019743:Chemokines, CXC; D019707:Receptors, Chemokine