title: Case of recurrence of spiradenoma in palpebral conjunctiva.
abstract: BACKGROUND
  To report a rare case of a recurrence of spiradenoma that developed in the upper eyelid.
  
  
  METHODS
  A 49-year-old woman who had a second recurrence of a tumor in the right palpebral conjunctiva underwent local resection of the lesion with adjunctive cryotherapy to the surgical site. The tumor consisted of smooth, round to oval nodular lesions approximately 1-3 mm in size with enlarged blood vessels. Histopathologically, the solid and well-circumscribed nodule was located beneath the conjunctival epithelium. It was composed of cells with slightly basophilic-to-clear cytoplasm and round-to-oval nuclei arranged in a trabecular pattern. Periodic acid-Schiff stain was positive in the cytoplasm, and the staining disappeared after digesting by diastase. Many cells in mitosis were observed throughout the tumor but no necrotic cells. Immunohistochemistry showed that the Ki-67 labeling index was 12%. From these findings, we diagnosed this tumor as a recurrence of the spiradenoma. There has been no recurrence and no signs of malignancy in the 6 months after the surgical excision.
  
  
  CONCLUSIONS
  Our findings indicate that a spiradenoma should be completely excised surgically because of malignant transformation after repeated recurrences.
authors: Shinya
authors: S
authors: Oie
authors: Department of Ophthalmology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu-shi 501-1194, Japan. sawadaa-gif@umin.ac.jp.
authors: Akira
authors: A
authors: Sawada
authors: Kiyofumi
authors: K
authors: Mochizuki
authors: Kozue
authors: K
authors: Tsuji
authors: Yoshinobu
authors: Y
authors: Hirose
authors: Chiemi
authors: C
authors: Saigo
authors: Hiroshi
authors: H
authors: Yoshikawa
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D003228:Conjunctiva / Q000473:pathology*; D003230:Conjunctival Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000378:metabolism; D013508:Ophthalmologic Surgical Procedures; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen