title: Artery buckling analysis using a four-fiber wall model.
abstract: Artery bent buckling has been suggested as a possible mechanism that leads to artery tortuosity, which is associated with aging, hypertension, atherosclerosis, and other pathological conditions. It is necessary to understand the relationship between microscopic wall structural changes and macroscopic artery buckling behavior. To this end, the objectives of this study were to develop arterial buckling equations using a microstructure-based 4-fiber reinforced wall model, and to simulate the effects of vessel wall microstructural changes on artery buckling. Our results showed that the critical pressure increased nonlinearly with the axial stretch ratio, and the 4-fiber model predicted higher critical buckling pressures than what the Fung model predicted. The buckling equation using the 4-fiber model captured the experimentally observed reduction of critical pressure induced by elastin degradation and collagen fiber orientation changes in the arterial wall. These results improve our understanding of arterial stability and its relationship to microscopic wall remodeling, and the model provides a useful tool for further studies.
authors: Department of Mechanical Engineering, University of Texas at San Antonio, San Antonio, TX 78249, USA.
authors: Qin
authors: Q
authors: Liu
authors: Orthopaedics Department, Shaanxi Province People׳s Second Hospital, Xi'an, China.
authors: Qi
authors: Q
authors: Wen
authors: Department of Mechanical Engineering, University of Texas at San Antonio, San Antonio, TX 78249, USA.
authors: Mohammad
authors: M
authors: Mottahedi
authors: Department of Mechanical Engineering, University of Texas at San Antonio, San Antonio, TX 78249, USA; Biomedical Engineering Program, UTSA-UTHSCSA, San Antonio, TX, USA; Institute of Mechanobiology & Medical Engineering, Shanghai Jiaotong University, China. Electronic address: haichao.han@utsa.edu.
authors: Hai-Chao
authors: HC
authors: Han
mesh_terms: D000818:Animals; D001158:Arteries / Q000002:abnormalities* / Q000503:physiopathology; D001696:Biomechanical Phenomena; D001794:Blood Pressure; D002339:Carotid Arteries / Q000502:physiology*; D005109:Extracellular Matrix / Q000502:physiology*; D007593:Joint Instability / Q000503:physiopathology*; D008955:Models, Cardiovascular; D011312:Pressure; D012873:Skin Diseases, Genetic / Q000503:physiopathology*; D013314:Stress, Mechanical; D013552:Swine; D054079:Vascular Malformations / Q000503:physiopathology*
keywords: Artery buckling; Artery wall; Collagen; Critical buckling pressure; Elastin; Extracellular matrix; Fiber model; Mechanical instability