title: The single nucleotide polymorphism rs2208454 confers an increased risk for ischemic stroke: a case-control study.
abstract: OBJECTIVE
  A recent genome-wide association study identified a strong association of covert magnetic resonance imaging infarcts with the single nucleotide polymorphism (SNP) rs2208454. The aim of this study was to determine whether the rs2208454 polymorphism is associated with an increased risk for ischemic stroke (IS).
  
  
  METHODS
  Ischemic stroke patients (n = 712) and control subjects (n = 774) from a southern Chinese Han population were included. The snapshot technique was used for genotype analysis.
  
  
  RESULTS
  Compared with the GT+GG or GG genotype, the frequency of the TT genotype was significantly higher in IS than in controls. After adjusting for age, gender, family history of IS, hypertension history, and history of diabetes mellitus, a significant correlation between the TT genotype and IS persisted (TT vs. GT+GG: adjusted OR = 1.79, 95% CI: 1.16-2.77; TT vs. GG: adjusted OR = 1.88, 95% CI: 1.20-2.94). In subgroup analyses, SNP rs2208454 was significantly associated with large artery atherosclerosis (LAA) (TT vs. GG: adjusted OR = 2.16, 95% CI: 1.19-3.93), but failed to show significant association with small-artery occlusion or cardioembolism IS subtypes.
  
  
  CONCLUSIONS
  Single nucleotide polymorphism rs2208454 confers an increased risk for IS in a southern Chinese Han population. When the IS subtype was examined, the effect of the SNP was restricted to LAA.
authors: Department of Neurology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China; Department of Neurology, First Affiliated Hospital, Guangxi Medical University, Nanning, China.
authors: Man
authors: M
authors: Luo
authors: Jiao-Xing
authors: JX
authors: Li
authors: Xun-Sha
authors: XS
authors: Sun
authors: Rong
authors: R
authors: Lai
authors: Yu-Fang
authors: YF
authors: Wang
authors: Xiao-Wei
authors: XW
authors: Xu
authors: Wen-Li
authors: WL
authors: Sheng
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000235:genetics; D002545:Brain Ischemia / Q000150:complications; D016022:Case-Control Studies; D002681:China; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D012737:Sex Factors; D020521:Stroke / Q000209:etiology / Q000235:genetics*
keywords: Ischemic stroke; Large artery atherosclerosis; Single nucleotide polymorphism; Stroke subtype; rs2208454