title: Role of cerebrospinal fluid IL-8 as a marker for differentiation between acute bacterial and aseptic meningitis.
abstract: No doubt, the distinguishing between bacterial and aseptic meningitis in the emergency department could help to limit unnecessary antibiotic use and hospital admissions. This study evaluated the role of cerebrospinal fluid IL-8 in differentiating acute bacterial meningitis (ABM) from aseptic meningitis (AM). A total of 80 hospitalized patients with clinical presentations of suspected acute meningitis were subjected to estimation of IL-8 CSF concentrations. The results showed that CSF IL-8 levels were higher in acute bacterial meningitis than in aseptic ones (p < 0.05). The best cut-off value of CSF IL8 for early diagnosis of bacterial meningitis was 3.6 ng/ml with a sensitivity of 82.5% and a specificity of 85.0%.
authors: Amal Tohamy
authors: AT
authors: Abdelmoez
authors: Doaa Zakaria
authors: DZ
authors: Zaky
authors: Amany M
authors: AM
authors: Maher
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000134:cerebrospinal fluid* / Q000235:genetics / Q000378:metabolism; D008297:Male; D008582:Meningitis, Aseptic / Q000134:cerebrospinal fluid* / Q000378:metabolism; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid* / Q000378:metabolism; D008875:Middle Aged; D055815:Young Adult
chemical_list: D015415:Biomarkers; D016209:Interleukin-8