title: Performance of FDG PET/CT at initial diagnosis in a rare lymphoma: nodular lymphocyte-predominant Hodgkin lymphoma.
abstract: OBJECTIVE
  Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare Hodgkin lymphoma distinguished from classical Hodgkin lymphoma (cHL) by the nature of the neoplastic cells which express B-cell markers. We wanted to determine the diagnostic performance of FDG PET/CT in initial assessment and its therapeutic impact on staging.
  
  
  METHODS
  We retrospectively studied a population of 35 patients with NLPHL (8 previously treated for NLHPL, 27 untreated). All patients underwent an initial staging by pretherapeutic FDG PET/CT. The impact on initial stage or relapse stage was assessed by an independent physician.
  
  
  RESULTS
  In a per-patient analysis, the sensitivity of the pretherapeutic FDG PET/CT was 100%. In a per-site analysis, the sensitivity, specificity, positive predictive value, negative predictive value and accuracy of pretherapeutic FDG PET/CT were 100%, 99%, 97%, 100% and 99%, respectively. Pretherapeutic FDG PET/CT led to a change in the initial stage/relapse stage in 12 of the 35 patients (34%). In contrast to previous results established without FDG PET/CT, 20% of patient had osteomedullary lesions.
  
  
  CONCLUSIONS
  Pretherapeutic FDG PET/CT has excellent performance for initial staging or relapse staging of NLPHL.
authors: AP-HP- Hôpital Européen Georges Pompidou, Service de médecine nucléaire, Paris, 75015, France, jeffgrellier@hotmail.fr.
authors: Jean François
authors: JF
authors: Grellier
authors: Laetitia
authors: L
authors: Vercellino
authors: Thierry
authors: T
authors: Leblanc
authors: Pascal
authors: P
authors: Merlet
authors: Catherine
authors: C
authors: Thieblemont
authors: Pierre
authors: P
authors: Weinmann
authors: Marie-Elisabeth
authors: ME
authors: Toubert
authors: Nathalie
authors: N
authors: Berenger
authors: Josette
authors: J
authors: Brière
authors: Pauline
authors: P
authors: Brice
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D019788:Fluorodeoxyglucose F18; D006689:Hodgkin Disease / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008214:Lymphocytes / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D019788:Fluorodeoxyglucose F18