title: Microwave assisted tandem Heck-Sonogashira reactions of N,N-di-Boc-protected 6-amino-5-iodo-2-methyl pyrimidin-4-ol in an efficient approach to functionalized pyrido[2,3-d]pyrimidines.
abstract: A microwave assisted tandem Heck-Sonogashira cross-coupling reaction between 6-N,N-di-Boc-amino-5-iodo-2-methyl pyrimidin-4-ol and various aryl alkynyl substrates has been developed. This process generates novel 5-enynyl substituted pyrimidines, which can be transformed to novel functionalized pyrido[2,3-d]pyrimidines by way of a silver catalyzed cyclization reaction.
authors: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 ZuChongZhi Road, Shanghai, 201203, China.
authors: Yang
authors: Y
authors: Liu
authors: Shiyu
authors: S
authors: Jin
authors: Zi
authors: Z
authors: Wang
authors: Linhua
authors: L
authors: Song
authors: Youhong
authors: Y
authors: Hu
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D008872:Microwaves; D015394:Molecular Structure; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry; D012834:Silver / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D011743:Pyrimidines; D012834:Silver