title: An efficient route for annulation of pyrimidines to steroids and non-steroids via a base catalyzed one-pot three component reaction.
abstract: A facile strategy for the synthesis of steroidal A- and D-ring fused pyrimidines has been accomplished in high yields via a one-pot reaction of steroidal ketones, aromatic aldehydes and amidine derivatives in presence of potassium tert-butoxide in refluxing ethanol. The generality of the reaction was also extended to non-steroidal ketones.
authors: Medicinal Chemistry Division, CSIR-North East Institute of Science and Technology, Jorhat 785006, Assam, India.
authors: Pallabi
authors: P
authors: Saikia
authors: Medicinal Chemistry Division, CSIR-North East Institute of Science and Technology, Jorhat 785006, Assam, India.
authors: Shyamalee
authors: S
authors: Gogoi
authors: Medicinal Chemistry Division, CSIR-North East Institute of Science and Technology, Jorhat 785006, Assam, India. Electronic address: skgogoi1@gmail.com.
authors: Sanjib
authors: S
authors: Gogoi
authors: Medicinal Chemistry Division, CSIR-North East Institute of Science and Technology, Jorhat 785006, Assam, India. Electronic address: rc_boruah@yahoo.co.in.
authors: Romesh C
authors: RC
authors: Boruah
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000578:Amidines / Q000737:chemistry; D000440:Butanols / Q000737:chemistry; D002384:Catalysis; D000431:Ethanol / Q000737:chemistry; D007659:Ketones / Q000737:chemistry; D011743:Pyrimidines / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry*; D013696:Temperature
chemical_list: D000447:Aldehydes; D000578:Amidines; D000440:Butanols; D007659:Ketones; D011743:Pyrimidines; D013256:Steroids; D000431:Ethanol; C077664:tert-butoxide, potassium
keywords: Amidine; Heterosteroid; Multicomponent reaction; Potassium tert-butoxide; Pyrimidine