title: Maternal venous hemodynamics in gestational hypertension and preeclampsia.
abstract: BACKGROUND
  To evaluate characteristics of venous hemodynamics, together with cardiac and arterial function, in uncomplicated pregnancies (UP), non-proteinuric gestational hypertension (GH) and preeclampsia (PE).
  
  
  METHODS
  In this observational cross-sectional study, venous hemodynamics was assessed using a standardised protocol for combined electrocardiogram (ECG)-Doppler ultrasonography, together with a non-invasive standardised cardiovascular assessment using impedance cardiography (ICG) in 13 women with UP, 21 with GH, 34 with late onset PE ≥ 34 w (LPE) and 22 with early onset PE < 34 w (EPE). ECG-Doppler parameters were impedance index at the level of hepatic veins (HVI) and renal interlobar veins (RIVI) together with venous pulse transit times (VPTT), as well as resistive and pulsatility index, and arterial pulse transit time (APTT) at the level of uterine arcuate arteries. ICG parameters were aortic flow velocity index (VI), acceleration index (ACI) and thoracic fluid content. Mann Whitney U-test, Kruskall-Wallis test and linear regression analysis with heteroskedastic variance was used for statistical analysis.
  
  
  RESULTS
  RIVI in both kidneys was >15% higher (P ≤ .010) in LPE and EPE, as compared to GH and UP. Next to this, >30% lower values for VI and ACI (P ≤ .029), and > 15% lower values for APTT (P ≤ .012) were found in GH, LPE and EPE, as compared to GH.
  
  
  CONCLUSIONS
  In comparison to UP, similar abnormalities of central arterial function and APTT were found in GH, EPE and LPE. Proteinuria of LPE and EPE was associated with increased RIVI, this was not observed in GH.
authors: Department of Obstetrics & Gynaecology, Ziekenhuis Oost, Limburg Schiepse Bos 6, 3600 Genk, Belgium. wilfried.gyselaers@zol.be.
authors: Wilfried
authors: W
authors: Gyselaers
authors: Kathleen
authors: K
authors: Tomsin
authors: Anneleen
authors: A
authors: Staelens
authors: Tinne
authors: T
authors: Mesens
authors: Jolien
authors: J
authors: Oben
authors: Geert
authors: G
authors: Molenberghs
mesh_terms: D000328:Adult; D001794:Blood Pressure; D002307:Cardiography, Impedance; D003430:Cross-Sectional Studies; D015150:Echocardiography, Doppler; D005260:Female; D005865:Gestational Age; D006439:Hemodynamics; D006503:Hepatic Veins / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000652:urine; D011225:Pre-Eclampsia / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011247:Pregnancy; D011507:Proteinuria / Q000652:urine; D063177:Pulse Wave Analysis; D012082:Renal Veins / Q000000981:diagnostic imaging / Q000503:physiopathology*; D013997:Time Factors; D014527:Uric Acid / Q000097:blood; D055988:Uterine Artery / Q000000981:diagnostic imaging / Q000503:physiopathology
chemical_list: D014527:Uric Acid