title: Importance of RhoGTPases in formation, characteristics, and functions of invadosomes.
abstract: Podosomes and invadopodia (collectively known as invadosomes) are specialized plasma-membrane actin-based microdomains that combine adhesive properties with matrix degrading and/or mechanosensor activities. These organelles have been extensively studied in vitro and current concerted efforts aim at establishing their physiological relevance and subsequent association with human diseases. Proper functioning of the bone, immune, and vascular systems is likely to depend on these structures while their occurrence in cancer cells appears to be linked to tumor metastasis. The elucidation of the mechanisms driving invadosome assembly is a prerequisite to understanding their role in vivo and ultimately to controlling their functions. Adhesive and soluble ligands act via transmembrane receptors that propagate signals to the cytoskeleton via small G proteins of the Rho family, assisted by tyrosine kinases and scaffold proteins to induce invadosome formation and rearrangements. Oncogene expression and cell-cell interactions may also trigger their assembly. Manipulation of the signals that regulate invadosome formation and dynamics could therefore be a strategy to interfere with their functions in a multitude of pathological settings, such as excessive bone breakdown, infections, vascular remodeling, transendothelial diapedesis, and metastasis.
authors: Université de Bordeaux; Bordeaux, France; INSERM U1045; Bordeaux, France; IECB; European Institute of Chemistry and Biology; Pessac, France.
authors: Pirjo
authors: P
authors: Spuul
authors: Université de Bordeaux; Bordeaux, France; INSERM U1045; Bordeaux, France; IECB; European Institute of Chemistry and Biology; Pessac, France.
authors: Paolo
authors: P
authors: Ciufici
authors: Université de Bordeaux; Bordeaux, France; INSERM U1045; Bordeaux, France; IECB; European Institute of Chemistry and Biology; Pessac, France.
authors: Véronique
authors: V
authors: Veillat
authors: Université de Bordeaux; Bordeaux, France; INSERM U1045; Bordeaux, France; IECB; European Institute of Chemistry and Biology; Pessac, France.
authors: Anne
authors: A
authors: Leclercq
authors: Université de Bordeaux; Bordeaux, France; INSERM U1045; Bordeaux, France; IECB; European Institute of Chemistry and Biology; Pessac, France.
authors: Thomas
authors: T
authors: Daubon
authors: Université de Bordeaux; Bordeaux, France; INSERM U1045; Bordeaux, France; IECB; European Institute of Chemistry and Biology; Pessac, France.
authors: Ĳsbrand
authors: Ĳ
authors: Kramer
authors: Université de Bordeaux; Bordeaux, France; INSERM U1045; Bordeaux, France; IECB; European Institute of Chemistry and Biology; Pessac, France.
authors: Elisabeth
authors: E
authors: Génot
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism; D000818:Animals; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D051316:Wiskott-Aldrich Syndrome Protein / Q000235:genetics / Q000378:metabolism; D020764:cdc42 GTP-Binding Protein / Q000378:metabolism; D020744:rac GTP-Binding Proteins / Q000378:metabolism; D020741:rho GTP-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D020742:rhoA GTP-Binding Protein / Q000378:metabolism
chemical_list: D051316:Wiskott-Aldrich Syndrome Protein; D020764:cdc42 GTP-Binding Protein; D020744:rac GTP-Binding Proteins; D020741:rho GTP-Binding Proteins; D020742:rhoA GTP-Binding Protein
keywords: RhoGTPases; cytoskeleton; extracellular matrix; invadopodia; invadosomes; podosomes