title: Third-line trabectedin for a metastatic desmoplastic small round cell tumour treated with multimodal therapy.
abstract: BACKGROUND
  Desmoplastic small round cell tumour (DSRCT) is a rare and aggressive cancer that usually develops in the peritoneal cavity of young males. Its prognosis is dismal, with current treatment options including the combination of multi-agent chemotherapy, aggressive surgery, radiation therapy, and autologous stem cell transplantation. Hyperthermic intraperitoneal chemotherapy (HIPEC) may also be an option.
  
  
  METHODS
  Herein we report the administration of the marine-derived multi-target antineoplastic agent, trabectedin, in a patient with DSRCT, heavily pre-treated with conventional multi-agent chemotherapy, HIPEC, and surgery.
  
  
  RESULTS
  The patient achieved a prolonged partial response and an extended period of stable disease with third-line trabectedin, following disease progression after conventional multi-agent chemotherapy, HIPEC, and surgery.
  
  
  CONCLUSIONS
  Trabectedin may be a treatment option in multimodal therapy for the management of DSRCT and warrants further research to explore the impact of trabectedin in the treatment of this disease.
authors: Medical Oncology Unit, National Cancer Institute "Giovanni Paolo II", Bari, Italy brunetti.ae@gmail.com.
authors: Anna Elisabetta
authors: AE
authors: Brunetti
authors: Scientific Direction, National Cancer Institute "Giovanni Paolo II", Bari, Italy.
authors: Sabina
authors: S
authors: Delcuratolo
authors: Medical Oncology Unit, National Cancer Institute "Giovanni Paolo II", Bari, Italy.
authors: Vito
authors: V
authors: Lorusso
authors: Medical Oncology Unit, National Cancer Institute "Giovanni Paolo II", Bari, Italy.
authors: Loredana
authors: L
authors: Palermo
authors: Department of Surgery, Sapienza University of Rome, Rome, Italy.
authors: Angelo
authors: A
authors: Di Giorgio
authors: Medical Oncology Unit, S.G. Moscati Hospital, Taranto, Italy.
authors: Salvatore
authors: S
authors: Pisconti
authors: Medical Oncology Unit, National Cancer Institute "Giovanni Paolo II", Bari, Italy.
authors: Nicola
authors: N
authors: Silvestris
mesh_terms: D000328:Adult; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use*; D058405:Desmoplastic Small Round Cell Tumor / Q000188:drug therapy*; D004149:Dioxoles / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D044005:Tetrahydroisoquinolines / Q000627:therapeutic use*; D000077606:Trabectedin; D055815:Young Adult
chemical_list: D018906:Antineoplastic Agents, Alkylating; D004149:Dioxoles; D044005:Tetrahydroisoquinolines; D000077606:Trabectedin
keywords: Chemotherapy; desmoplastic small round cell tumour; multimodal therapy; trabectedin