title: MAPLE fabricated Fe3O4@Cinnamomum verum antimicrobial surfaces for improved gastrostomy tubes.
abstract: Cinnamomum verum-functionalized Fe3O4 nanoparticles of 9.4 nm in size were laser transferred by matrix assisted pulsed laser evaporation (MAPLE) technique onto gastrostomy tubes (G-tubes) for antibacterial activity evaluation toward Gram positive and Gram negative microbial colonization. X-ray diffraction analysis of the nanoparticle powder showed a polycrystalline magnetite structure, whereas infrared mapping confirmed the integrity of C. verum (CV) functional groups after the laser transfer. The specific topography of the deposited films involved a uniform thin coating together with several aggregates of bio-functionalized magnetite particles covering the G-tubes. Cytotoxicity assays showed an increase of the G-tube surface biocompatibility after Fe3O4@CV treatment, allowing a normal development of endothelial cells up to five days of incubation. Microbiological assays on nanoparticle-modified G-tube surfaces have proved an improvement of anti-adherent properties, significantly reducing both Gram negative and Gram positive bacteria colonization.
authors: ENT, "Carol Davila" University of Medicine and Pharmacy, Traian Vuia no.6, Bucharest 020956, Romania. dr_alina.anghel@yahoo.com.
authors: Alina Georgiana
authors: AG
authors: Anghel
authors: Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Polizu Street no 1-7, Bucharest 011061, Romania. grumezescu@yahoo.com.
authors: Alexandru Mihai
authors: AM
authors: Grumezescu
authors: Departamento de Química Fisica, Universidade de Vigo, 36310 Vigo, Pontevedra, Spain. mariana.chirea@uvigo.es.
authors: Mariana
authors: M
authors: Chirea
authors: Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Polizu Street no 1-7, Bucharest 011061, Romania. gabriel.socol@inflpr.ro.
authors: Valentina
authors: V
authors: Grumezescu
authors: National Institute for Lasers, Plasma & Radiation Physics, Lasers Department, P.O. Box MG-36, Bucharest-Magurele, Bucharest 769231, Romania. gabriel.socol@inflpr.ro.
authors: Gabriel
authors: G
authors: Socol
authors: Flow Cytometry and Cell Therapy Laboratory, Institute of Cellular Biology and Pathology "Nicolae Simionescu" (ICBP), Bucharest 050568, Romania. floriniordache84@yahoo.com.
authors: Florin
authors: F
authors: Iordache
authors: Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Polizu Street no 1-7, Bucharest 011061, Romania. elena_oprea_93@yahoo.co.uk.
authors: Alexandra Elena
authors: AE
authors: Oprea
authors: ENT, "Carol Davila" University of Medicine and Pharmacy, Traian Vuia no.6, Bucharest 020956, Romania. ionangheldoc@yahoo.com.
authors: Ion
authors: I
authors: Anghel
authors: Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Polizu Street no 1-7, Bucharest 011061, Romania. alina_m_h@yahoo.com.
authors: Alina Maria
authors: AM
authors: Holban
mesh_terms: D018441:Biofilms; D055499:Catheter-Related Infections / Q000517:prevention & control; D002460:Cell Line; D002935:Cinnamomum zeylanicum / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D004750:Enteral Nutrition; D004926:Escherichia coli / Q000254:growth & development; D005774:Gastrostomy; D006801:Humans; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000254:growth & development; D014961:X-Ray Diffraction
chemical_list: D020099:Coated Materials, Biocompatible; D058185:Magnetite Nanoparticles; D010936:Plant Extracts