title: Dopaminergic function in relation to genes associated with risk for schizophrenia: translational mutant mouse models.
abstract: Mutant mice play an increasingly important role in understanding disease processes at multiple levels. In particular, they illuminate the impact of risk genes for disease on such processes. This article reviews recent advances in the application of mutant mice to study the intricacies of dopaminergic (DAergic) function in relation to the putative pathophysiology of psychotic illness, particularly schizophrenia, and antipsychotic drug action. It considers models for understanding the role(s) of risk genes, with a particular focus on DTNBP1 and NRG1, their interactions with environmental factors, and with each other (epistasis). In overview, it considers new schemas for understanding psychotic illness that integrate DAergic pathophysiology with developmental, social, and cognitive processes, and how mutant mouse models can reflect and inform on such schemas.
authors: School of Psychology, University of Nottingham, Nottingham, UK.
authors: Paula M
authors: PM
authors: Moran
authors: School of Medicine, University College Cork, Cork, Ireland.
authors: Colm M P
authors: CM
authors: O'Tuathaigh
authors: Department of Neuroscience and Brain Technologies, Instituto Italiano di Tecnologia, Genova, Italy.
authors: Francesco
authors: F
authors: Papaleo
authors: Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland. Electronic address: jwadding@rcsi.ie.
authors: John L
authors: JL
authors: Waddington
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004298:Dopamine / Q000235:genetics* / Q000378:metabolism; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins / Q000235:genetics; D051379:Mice; D020890:Neuregulin-1 / Q000235:genetics; D012559:Schizophrenia / Q000235:genetics* / Q000378:metabolism
chemical_list: C498992:Dtnbp1 protein, mouse; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; D020890:Neuregulin-1; C490581:Nrg1 protein, mouse; D004298:Dopamine
keywords: DTNBP1; NRG1; dopamine; dysbindin; mutant mice; psychosis; risk genes; schizophrenia