title: A new case of syringocystadenocarcinoma papilliferum: a rare pathology for a wide-ranging comprehension.
abstract: We report a new case of p63/cytokeratin 7 (CK7) positive syringocystadenocarcinoma papilliferum (SCACP), on the shoulder of an 88-year-old man, with superficial dermal infiltration and squamoid differentiation. We describe the 24th case of SCACP, the malignant counterpart of syringocystadenoma papilliferum (SCAP). At the present, we do not know whether SCACP arises from eccrine or apocrine glands because of the contrasting opinions in the literature. Only few histochemical and ultrastructural studies have previously advised that SCACP could arise from pluripotent stem cells. Through our case, we wish to suggest the stem cell-like properties of the syringocystadenocarcinoma papilliferum. This rare neoplasm shows two different patterns of stem cell marker expression in the glandular and squamous components, respectively. For the double phenotype of SCACP, we propose it like an intriguing model to study histogenesis and stem cell properties for more wide-ranging epithelial tumors.
authors: Department of Morphology, Surgery and Experimental Medicine, Section of Anatomic Pathology, University of Ferrara and S. Anna University Hospital Via Aldo Moro, 8, 44124 Cona, Ferrara, Italy ; Department of Medical Sciences, Section of Pharmacology and Neuroscience Center, University of Ferrara, Via Aldo Moro, 8, 44124 Cona, Italy ; National Institute of Neuroscience, Italy.
authors: Beatrice
authors: B
authors: Paradiso
authors: Department of Morphology, Surgery and Experimental Medicine, Section of Anatomic Pathology, University of Ferrara and S. Anna University Hospital Via Aldo Moro, 8, 44124 Cona, Ferrara, Italy.
authors: Enzo
authors: E
authors: Bianchini
authors: Department of Medical Sciences, Section of Pharmacology and Neuroscience Center, University of Ferrara, Via Aldo Moro, 8, 44124 Cona, Italy ; Ri.MED Foundation, Palermo, Italy.
authors: Pierangelo
authors: P
authors: Cifelli
authors: Department of Morphology, Surgery and Experimental Medicine, Section of Anatomic Pathology, University of Ferrara and S. Anna University Hospital Via Aldo Moro, 8, 44124 Cona, Ferrara, Italy.
authors: Luigi
authors: L
authors: Cavazzini
authors: Department of Morphology, Surgery and Experimental Medicine, Section of Anatomic Pathology, University of Ferrara and S. Anna University Hospital Via Aldo Moro, 8, 44124 Cona, Ferrara, Italy.
authors: Giovanni
authors: G
authors: Lanza