title: Hepatitis B vaccine immunogenicity among nurses of a hospital.
abstract: The aim of this study was to determine the factors affecting hepatitis B vaccine immunogenicity among nursing staff of Teaching Hospital, Jaffna. 152 nursing staffs were recruited from April to July 2013. Those who received three doses had 7.7% failure rate in developing protective immune response. Failure rates were 20% in those who received one dose and 10.6% in two doses. Following vaccination, participants who had chickenpox had a failure rate of 75% (n=13; p=0.02). Pregnancy significantly impaired protective immunity among those who received two doses (p=0.03). Three doses of hepatitis B vaccine may not be sufficient to protect the vaccinees. Therefore assessment of HBsAb titres is warranted after vaccination.
authors: Department of Pathology, Faculty of Medicine, University of Jaffna, Sri Lanka. kalamathy6@gmail.com.
authors: V
authors: V
authors: Piratheepkumar
authors: S
authors: S
authors: Kulendran
authors: S
authors: S
authors: Nadarajah
authors: K
authors: K
authors: Murugananthan
mesh_terms: D000328:Adult; D002644:Chickenpox / Q000276:immunology; D005260:Female; D006510:Hepatitis B Antibodies / Q000097:blood*; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D017325:Hepatitis B Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D006801:Humans; D008297:Male; D009741:Nursing Staff, Hospital; D011247:Pregnancy / Q000276:immunology; D013188:Sri Lanka; D055815:Young Adult
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines