title: Actual status of therapeutic vaccination in non-small cell lung cancer.
abstract: Lung cancer is the leading cause of cancer-related death worldwide. Although treatment methods such as surgery, radiotherapy and/or chemotherapy have improved, prognosis remains unsatisfactory, and developing new therapeutic strategies is still an urgent matter. Immunotherapy is a novel therapeutic approach wherein activated immune cells can specifically kill tumour cells. Several lung cancer vaccines have demonstrated prolonged survival time in phase II and III trials, and several clinical trials are under investigation. However, many clinical trials involving cancer vaccination with defined tumour antigens have shown this method to work only in a small number of patients. Cancer immunotherapy is not completely effective in eradicating tumour cells because they evade host immune control.
authors: Department of Clinical Oncology with the Subdepartment of Diurnal Chemotherapy, Wielkopolska Center of Pulmonology and Thoracosurgery of Eugenia and Janusz Zeyland, Poznan, Poland.
authors: Katarzyna
authors: K
authors: Szyszka-Barth
authors: Clinic Hospital, Poznan University of Medical Sciences, Poland.
authors: Katarzyna
authors: K
authors: Ramlau
authors: Department of Pulmonology, Allergology and Lung Oncology, Poznan University of Medical Sciences, Poland.
authors: Joanna
authors: J
authors: Goździk-Spychalska
authors: Department of Clinical Oncology with the Subdepartment of Diurnal Chemotherapy, Wielkopolska Center of Pulmonology and Thoracosurgery of Eugenia and Janusz Zeyland, Poznan, Poland.
authors: Lukasz
authors: L
authors: Spychalski
authors: Department of Clinical Oncology with the Subdepartment of Diurnal Chemotherapy, Wielkopolska Center of Pulmonology and Thoracosurgery of Eugenia and Janusz Zeyland, Poznan, Poland.
authors: Maciej
authors: M
authors: Bryl
authors: Department of Clinical Oncology with the Subdepartment of Diurnal Chemotherapy, Wielkopolska Center of Pulmonology and Thoracosurgery of Eugenia and Janusz Zeyland, Poznan, Poland.
authors: Iwona
authors: I
authors: Gołda-Gocka
authors: Department of Chemotherapy, Poznan University of Medical Sciences, Poland.
authors: Anna
authors: A
authors: Kopczyńska
authors: Adult Pulmonary-Rehabilitation Department, Wielkopolska Center of Pulmonology and Thoracosurgery of Eugenia and Janusz Zeyland, Poznan, Poland.
authors: Aleksander
authors: A
authors: Barinow-Wojewódzki
authors: Department of Clinical Oncology with the Subdepartment of Diurnal Chemotherapy, Wielkopolska Center of Pulmonology and Thoracosurgery of Eugenia and Janusz Zeyland, Poznan, Poland ; Thoracosurgery Clinic, Poznan University of Medical Sciences, Poland.
authors: Rodryg
authors: R
authors: Ramlau
keywords: immunotherapy; non-small cell lung cancer; vaccines