title: The incidence of postoperative thromboembolic complications following surgical resection of intracranial meningioma. A retrospective study of a large single center patient cohort.
abstract: BACKGROUND
  Patients with meningiomas carry an increased risk for postoperative venous thromboembolic complications (VTE) including deep venous thrombosis (DVT) and pulmonary embolism (PE).
  
  
  OBJECTIVE
  In the present retrospective study we investigated the incidence of VTE and the risk factors involved, in a large cohort of patients surgically treated for an intracranial meningioma at our institution.
  
  
  METHODS
  During the period from January 1997 to January 2009, 581 consecutive patients underwent craniotomy for intracranial meningioma. All patients received low-molecular weight heparins as thromboembolism prophylaxis. Patient demographics and tumor characteristics were gathered via retrospective chart review. Postoperative VTE and hemorrhages were noted. Backward stepwise logistic regression was used to determine the risk factors.
  
  
  RESULTS
  80.6% of meningiomas were WHO grade 1; 15.1% WHO grade 2; 4.3% WHO grade 3. Postoperative VTE were observed in 41 patients (7.2%). Of these, DVT was seen in 20 (3.5%) and PE in 26 patients (4.6%). The thromboembolic complication appeared on average 21.1±29.2 days post surgery. The 90-day mortality rate after VTE was 11.2% (23.1% for PE and 5.0% for DVT). Postoperative hemorrhages requiring surgical treatment were found in 2.9% of patients. Risk factors for VTE were body mass index (p=0.015) for DVT; weight (p=0.001) and bedridden postoperatively (p=0.001) for PE; and weight (p=0.004) and bedridden postoperatively (p=0.003) for VTE in general. There was no relation between tumor grade and thromboembolic complications.
  
  
  CONCLUSIONS
  The major risk factors for postoperative VTE found in our single center study are patient weight and a bedridden status postoperatively. Prophylactic intervention for this potentially fatal complication should be evaluated against the relative lower risk of postoperative hemorrhages.
authors: Department of Neurosurgery, Erasmus MC, Rotterdam, The Netherlands.
authors: Daphna
authors: D
authors: Hoefnagel
authors: Department of Neurosurgery, Erasmus MC, Rotterdam, The Netherlands.
authors: Lesley E
authors: LE
authors: Kwee
authors: Department of Neurosurgery, Slotervaartziekenhuis, Amsterdam, The Netherlands.
authors: Erik H P
authors: EH
authors: van Putten
authors: Department of Neuropathology, Erasmus MC, Rotterdam, The Netherlands.
authors: Johan M
authors: JM
authors: Kros
authors: Department of Neurosurgery, Erasmus MC, Rotterdam, The Netherlands.
authors: Clemens M F
authors: CM
authors: Dirven
authors: Department of Neurosurgery, Erasmus MC, Rotterdam, The Netherlands. Electronic address: r.dammers@erasmusmc.nl.
authors: Ruben
authors: R
authors: Dammers
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000627:therapeutic use; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008577:Meningeal Neoplasms / Q000601:surgery; D008579:Meningioma / Q000150:complications / Q000601:surgery*; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology*; D011655:Pulmonary Embolism / Q000453:epidemiology*; D012189:Retrospective Studies; D012307:Risk Factors; D013923:Thromboembolism / Q000453:epidemiology*; D020246:Venous Thrombosis / Q000453:epidemiology*
chemical_list: D000925:Anticoagulants
keywords: Meningioma; Post-operative mobilisation; Risk stratification model; Venous thromboembolic complications; Weight