title: Steroidal esters from Ferula sinkiangensis.
abstract: Two new steroidal esters with an unusual framework, Sinkiangenorin A and B, a new organic acid glycoside, Sinkiangenorin C, and four known lignin compounds were isolated from the seeds of Ferula sinkiangensis. The structures of these compounds were established by spectroscopic analysis and single-crystal X-ray diffraction. All of the isolated compounds were tested against Hela, K562 and AGS human cancer cell lines. Sinkiangenorin C showed cytotoxic activity against AGS cells with an IC50 of 36.9 μM.
authors: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China.
authors: Guangzhi
authors: G
authors: Li
authors: Xinjiang Institute of Chinese Materia Medica and Ethical Materia Medica, Urumqi 830002, China.
authors: Xiaojin
authors: X
authors: Li
authors: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China.
authors: Li
authors: L
authors: Cao
authors: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China.
authors: Liangang
authors: L
authors: Shen
authors: Xinjiang Institute of Chinese Materia Medica and Ethical Materia Medica, Urumqi 830002, China.
authors: Jun
authors: J
authors: Zhu
authors: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China.
authors: Jing
authors: J
authors: Zhang
authors: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China.
authors: Junchi
authors: J
authors: Wang
authors: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China.
authors: Lijing
authors: L
authors: Zhang
authors: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China. Electronic address: jianyongsi@126.com.
authors: Jianyong
authors: J
authors: Si
mesh_terms: D004354:Drug Screening Assays, Antitumor; D004952:Esters; D005309:Ferula / Q000737:chemistry*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification*; D006367:HeLa Cells; D006801:Humans; D020014:K562 Cells; D015394:Molecular Structure; D010421:Pentanoic Acids / Q000737:chemistry / Q000302:isolation & purification*; D010840:Phytosterols / Q000737:chemistry / Q000302:isolation & purification; D012639:Seeds / Q000737:chemistry
chemical_list: C000596998:2-(1-hydroxyethyl)-4-methylpentanoic acid-4-O-glucopyranoside; D004952:Esters; D005960:Glucosides; D010421:Pentanoic Acids; D010840:Phytosterols
keywords: Arctigenin (PubChem CID: 64981); Cytotoxic activities; Ferula sinkiangensis; Lariciresinol (PubChem CID: 332427); Lignin compounds; Matairesinol (PubChem CID: 119205); Organic acid glycoside; Secroisolariciresinol (PubChem CID: 6336781); Steroidal esters