title: Synthesis and evaluation of 2,4-disubstituted quinazoline derivatives with potent anti-angiogenesis activities.
abstract: A series of 2,4-disubstituted quinazoline derivatives were designed and synthesized. The biological results showed that most of quinazoline derivatives exhibited potent antiproliferative activities against a panel of three tumor cell lines and a good inhibitory effect against the adhesion and migration of human umbilical vein endothelial cells (HUVECs). Among these compounds, 11d was the most potent agent, that also exhibited the highest anti-angiogenesis activities in the chick embryo chorioallantoic membrane (CAM) assay.
authors: Department of Chirurgery, First Affiliated Hospital of Anhui Medical University, Hefei 230032, China. yusysu@163.com.
authors: Guangjin
authors: G
authors: Yu
authors: Department of Chemistry, Anhui Medical University, Hefei 230032, China. stronglz110732@163.com.
authors: Zeng
authors: Z
authors: Li
authors: Department of Chirurgery, First Affiliated Hospital of Anhui Medical University, Hefei 230032, China. tang@163.com.
authors: Liang
authors: L
authors: Tang
authors: Department of Chirurgery, First Affiliated Hospital of Anhui Medical University, Hefei 230032, China. xiongqiru@gmail.com.
authors: Qiru
authors: Q
authors: Xiong
mesh_terms: D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D002642:Chick Embryo; D049033:Chorioallantoic Membrane / Q000098:blood supply / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects / Q000502:physiology; D006801:Humans; D020128:Inhibitory Concentration 50; D018919:Neovascularization, Physiologic / Q000187:drug effects; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D020533:Angiogenesis Inhibitors; D011799:Quinazolines