title: [Expression and clinical significance of CD45RO in laryngeal carcinoma tissue].
abstract: OBJECTIVE
  To investigate the role and significance of CD45RO in occurance and development in laryngeal squamous carcinoma, and to provide some valuable clues for searching new approaches to assess prognosis and theoretical basis for tumor biotherapy.
  
  
  METHODS
  The expression of CD45RO protein in 50 cases of laryngeal squamous carcinoma and 10 cases normal mucos was detected by immunohistochemical S-P method.
  
  
  RESULTS
  The positive rate of CD45RO was 30% and 86% respectively in normal tissue and laryngeal squamous cell carcinoma tissue. The expresion of CD45RO was significantly and negatively associated with local metastatic of lymph nodes 0.713, P < 0.05) and tumor sites (r = -0.750, P < 0.05), but it have no notable difference with pathology differentiation, age, infiltrating depth and clinical stages in 50 cases of laryngeal squamous cell cancer.
  
  
  CONCLUSIONS
  (1) The expresion of CD45RO in laryngeal squamous cell cancer is more than that in normal tissue. (2) It is possible that overexpresion of CD45RO in laryngeal squamous cell carcinoma cut local metastatic lymph nodes. (3) It is probable that overexpresion of CD45RO in laryngeal squamous cell cancer made for prognosis of patients. (4) Other than UICC-TNM stage, pathology differentiation, it provide valuable clues for searching new approaches to assess prognosis of laryngeal squamous cell carcinoma.
authors: Manyi
authors: M
authors: Li
authors: Jishengi
authors: J
authors: Liu
authors: Hui
authors: H
authors: Zhou
authors: Wenying
authors: W
authors: Wu
authors: Gensheng
authors: G
authors: Xiao
authors: Yafeng
authors: Y
authors: Yu
authors: Lingchuan
authors: L
authors: Guo
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000473:pathology / Q000556:secondary; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000097:blood* / Q000473:pathology; D017493:Leukocyte Common Antigens / Q000097:blood*; D008198:Lymph Nodes; D008207:Lymphatic Metastasis; D008297:Male; D011379:Prognosis
chemical_list: D017493:Leukocyte Common Antigens