title: Hyper-adhesion: a unique property of desmosomes.
abstract: Hyper-adhesion is a unique, strongly adhesive form of desmosomal adhesion that functions to maintain tissue integrity. In this short review, we define hyper-adhesion, summarise the evidence for it in culture and in vivo, discuss its role in development, wound healing, and skin disease, and speculate about its molecular and cellular basis.
authors: Faculty of Life Sciences, University of Manchester , Manchester , UK.
authors: David
authors: D
authors: Garrod
authors: Lydia
authors: L
authors: Tabernero
mesh_terms: D000818:Animals; D002118:Calcium / Q000737:chemistry / Q000378:metabolism; D002448:Cell Adhesion; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D003896:Desmosomes / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D010392:Pemphigus / Q000378:metabolism / Q000473:pathology; D051571:Protein Kinase C-alpha / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D014945:Wound Healing
chemical_list: D051571:Protein Kinase C-alpha; D002118:Calcium
keywords: cell–cell adhesion; desmosomal cadherin; desmosome; development; pemphigus; wound healing