title: The influence of oxidative stress on symptom occurrence, severity, and distress during childhood leukemia treatment.
abstract: OBJECTIVE
  To explore the symptom trajectory during the first 16 months of childhood leukemia treatment and any associations with the oxidative stress pathway measured by cerebrospinal fluid (CSF) concentration of oxidized phosphatidylcholine (PC), the predominant glycerophospholipid in the brain and cell membranes.
  
  
  METHODS
  Prospective, longitudinal design.
  
  
  METHODS
  Two cancer centers in the southwestern United States.
  
  
  METHODS
  36 children (aged 3-14 years) newly diagnosed with acute lymphoblastic leukemia.
  
  
  METHODS
  Symptoms were measured using the Memorial Symptom Assessment Scale at six specific time points during treatment. Biochemical changes in oxidative stress were measured by oxidized PC in the CSF.
  
  
  METHODS
  Childhood cancer symptoms, oxidized PC.
  
  
  RESULTS
  Significant differences were found in the number of symptoms experienced during the three phases of treatment. Symptom trajectory changes and influence of the oxidative stress pathway on symptom experiences were identified.
  
  
  CONCLUSIONS
  Symptoms experienced during treatment for childhood leukemia are associated with increased oxidative stress.
  
  
  CONCLUSIONS
  Children with leukemia experience symptoms throughout treatment. Physiologic measures indicate the influence of oxidative stress on symptoms.
authors: School of Nursing, Duke University, Durham, NC.
authors: Marilyn J
authors: MJ
authors: Hockenberry
authors: College of Medicine, Baylor University, Houston, TX.
authors: Olga A
authors: OA
authors: Taylor
authors: College of Nursing, University of Arizona in Tucson.
authors: Alice
authors: A
authors: Pasvogel
authors: School of Nursing, Duke University.
authors: Cheryl
authors: C
authors: Rodgers
authors: College of Medicine, Baylor University.
authors: Kathy
authors: K
authors: McCarthy
authors: College of Nursing, University of Arizona.
authors: Patricia
authors: P
authors: Gundy
authors: College of Nursing, University of Arizona.
authors: David W
authors: DW
authors: Montgomery
authors: College of Medicine, Baylor University.
authors: Phillip
authors: P
authors: Ribbeck
authors: Population Sciences Biorepository, College of Medicine at Baylor University.
authors: Michael E
authors: ME
authors: Scheurer
authors: Biobehavioral Health Science Division in the College of Nursing, University of Arizona.
authors: Ida M Ki
authors: IM
authors: Moore
mesh_terms: D000293:Adolescent; D000342:Affective Symptoms / Q000523:psychology*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005221:Fatigue / Q000139:chemically induced / Q000451:nursing / Q000523:psychology; D005260:Female; D006801:Humans; D007938:Leukemia / Q000188:drug therapy / Q000451:nursing / Q000523:psychology; D008137:Longitudinal Studies; D008223:Lymphoma / Q000188:drug therapy / Q000451:nursing / Q000523:psychology; D008297:Male; D019964:Mood Disorders / Q000139:chemically induced / Q000451:nursing / Q000523:psychology; D009325:Nausea / Q000139:chemically induced / Q000451:nursing / Q000523:psychology; D009859:Oncology Nursing / Q000379:methods*; D018384:Oxidative Stress / Q000502:physiology*; D010146:Pain / Q000139:chemically induced / Q000451:nursing / Q000523:psychology; D011446:Prospective Studies; D012720:Severity of Illness Index; D014839:Vomiting / Q000139:chemically induced / Q000451:nursing / Q000523:psychology
chemical_list: D000970:Antineoplastic Agents
keywords: fatigue; leukemia/lymphomas/hematology; symptoms