title: Acanthomanzamines A-E with new manzamine frameworks from the marine sponge Acanthostrongylophora ingens.
abstract: Five new manzamine alkaloids, acanthomanzamines A-E, were isolated from the marine sponge Acanthostrongylophora ingens. Acanthomanzamines A and B are the first examples, containing a tetrahydroisoquinoline instead of a β-carboline in manzamine-related alkaloids. Acanthomanzamine C contains a hexahydrocyclopenta[b]pyrrol-4(2H)-one ring that may be converted from an eight-membered ring in manzamine A. Acanthomanzamines D and E have an additional oxazolidine and 2-methyloxazolidine rings, respectively, which fuse to the manzamine skeleton.
authors: Graduate School of Pharmaceutical Sciences, Kumamoto University , 5-1 Oe-honmachi, Kumamoto 862-0973, Japan.
authors: Akane
authors: A
authors: Furusato
authors: Hikaru
authors: H
authors: Kato
authors: Tatsuo
authors: T
authors: Nehira
authors: Keisuke
authors: K
authors: Eguchi
authors: Tetsuro
authors: T
authors: Kawabata
authors: Yukio
authors: Y
authors: Fujiwara
authors: Fitje
authors: F
authors: Losung
authors: Remy E P
authors: RE
authors: Mangindaan
authors: Nicole J
authors: NJ
authors: de Voogd
authors: Motohiro
authors: M
authors: Takeya
authors: Hideyoshi
authors: H
authors: Yokosawa
authors: Sachiko
authors: S
authors: Tsukamoto
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D002227:Carbazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D002227:Carbazoles; C078290:manzamine A