title: Dendrimeric tetravalent ligands for the serotonin-gated ion channel.
abstract: Multivalency is widely used in nature in specific recognition processes. This paper describes an approach to multivalency in the pentameric 5-HT3 receptor, a ligand-gated ion channel, which constitutes an example of intrinsically multivalent biological receptors. Owing to the picomolar Ki value, TETRA-L represents an outstanding multivalent ligand for the neurotransmitter receptor.
authors: Dipartimento di Biotecnologie, Chimica e Farmacia and European Research Centre for Drug Discovery and Development, Università degli Studi di Siena, Via A. Moro 2, 53100 Siena, Italy. andrea.cappelli@unisi.it.
authors: Marco
authors: M
authors: Paolino
authors: Laura
authors: L
authors: Mennuni
authors: Germano
authors: G
authors: Giuliani
authors: Maurizio
authors: M
authors: Anzini
authors: Marco
authors: M
authors: Lanza
authors: Gianfranco
authors: G
authors: Caselli
authors: Chiara
authors: C
authors: Galimberti
authors: Maria Cristina
authors: MC
authors: Menziani
authors: Alessandro
authors: A
authors: Donati
authors: Andrea
authors: A
authors: Cappelli
mesh_terms: D050091:Dendrimers / Q000138:chemical synthesis* / Q000494:pharmacology; D007473:Ion Channels / Q000378:metabolism*; D007700:Kinetics; D008958:Models, Molecular; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology; D044406:Receptors, Serotonin, 5-HT3 / Q000378:metabolism*; D013816:Thermodynamics
chemical_list: D050091:Dendrimers; D007473:Ion Channels; D010879:Piperazines; D044406:Receptors, Serotonin, 5-HT3