title: IL-6, IL-10 and IL-17 gene polymorphisms in Iranian women with recurrent miscarriage.
abstract: BACKGROUND
  Pro-inflammatory and anti-inflammatory cytokines and polymorphisms of their genes have been described to be involved in the pathogenesis of recurrent miscarriage (RM).
  
  
  OBJECTIVE
  To investigate the association between RM and five polymorphisms of cytokine genes, interleukin 10 (IL-10), (-592 A/C, -819 C/T, -1082 A/G), IL-6 (-174 C/G) and IL-17 (-197 G/A) in Iranian women.
  
  
  METHODS
  Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed to determine the frequencies of the IL-6, IL-10 and IL-17 gene polymorphisms in 85 women with RM compared with 104 healthy controls.
  
  
  RESULTS
  The frequencies of IL-10 promoter gene polymorphisms (-592 A/C and -819 C/T) were significantly higher in RM women than those in controls (p=0.003). However, no statistically significant differences were observed in the frequencies of IL-6 (-174 C/G), IL-10 (-1082 A/G) and IL-17 (-197 G/A) polymorphisms between RM women and controls.
  
  
  CONCLUSIONS
  These results suggest that IL-10 gene polymorphism screening might have some relevance in patients with RM, a suggestion which requires further studies.
authors: Monoclonal Antibody Research Center, Avicenna Research Institute, ACECR, Tehran, Iran, e-mail: Tannaz.bahadori@yahoo.com.
authors: Motahareh
authors: M
authors: Bahadori
authors: Saeed
authors: S
authors: Zarei
authors: Amir Hassan
authors: AH
authors: Zarnani
authors: Omid
authors: O
authors: Zarei
authors: Farah
authors: F
authors: Idali
authors: Reza
authors: R
authors: Hadavi
authors: Mahmood
authors: M
authors: Jeddi-Tehrani
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D020381:Interleukin-17 / Q000235:genetics*; D015850:Interleukin-6 / Q000235:genetics*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy
chemical_list: D020381:Interleukin-17; D015850:Interleukin-6; D016753:Interleukin-10