title: An association study between genetic polymorphism in the interleukin-6 receptor gene and coronary heart disease.
abstract: The goal of our study is to test the association of IL6R rs7529229 polymorphism with CHD through a case-control study in Han Chinese population and a meta-analysis. Our result showed there is a lack of association between IL6R rs7529229 polymorphism and CHD on both genotype and allele levels in Han Chinese (P > 0.05). However, a meta-analysis among 11678 cases and 12861 controls showed that rs7529229-C allele was significantly associated with a decreased risk of CHD, especially in Europeans (P < 0.0001, odds ratio = 0.93, 95% confidential interval = 0.89-0.96). Since there is significant difference among different populations, further studies are warranted to test the contribution of rs7529229 to CHD in other ethnic populations.
authors: Ningbo Medical Center, Lihuili Hospital, Ningbo University, 57 Xingning Road, Ningbo, Zhejiang 315211, China.
authors: Jiangqing
authors: J
authors: Zhou
authors: Ningbo Medical Center, Lihuili Hospital, Ningbo University, 57 Xingning Road, Ningbo, Zhejiang 315211, China ; School of Medicine, Ningbo University, 818 Fenghua Road, Ningbo, Zhejiang 315211, China.
authors: Xiaoliang
authors: X
authors: Chen
authors: School of Medicine, Ningbo University, 818 Fenghua Road, Ningbo, Zhejiang 315211, China.
authors: Huadan
authors: H
authors: Ye
authors: Ningbo Medical Center, Lihuili Hospital, Ningbo University, 57 Xingning Road, Ningbo, Zhejiang 315211, China ; School of Medicine, Ningbo University, 818 Fenghua Road, Ningbo, Zhejiang 315211, China.
authors: Ping
authors: P
authors: Peng
authors: Ningbo Medical Center, Lihuili Hospital, Ningbo University, 57 Xingning Road, Ningbo, Zhejiang 315211, China ; School of Medicine, Ningbo University, 818 Fenghua Road, Ningbo, Zhejiang 315211, China.
authors: Yanna
authors: Y
authors: Ba
authors: Ningbo Medical Center, Lihuili Hospital, Ningbo University, 57 Xingning Road, Ningbo, Zhejiang 315211, China.
authors: Xi
authors: X
authors: Yang
authors: Ningbo Medical Center, Lihuili Hospital, Ningbo University, 57 Xingning Road, Ningbo, Zhejiang 315211, China.
authors: Xiaoyan
authors: X
authors: Huang
authors: Ningbo Medical Center, Lihuili Hospital, Ningbo University, 57 Xingning Road, Ningbo, Zhejiang 315211, China.
authors: Yae
authors: Y
authors: Lu
authors: Ningbo Medical Center, Lihuili Hospital, Ningbo University, 57 Xingning Road, Ningbo, Zhejiang 315211, China.
authors: Xin
authors: X
authors: Jiang
authors: Ningbo Medical Center, Lihuili Hospital, Ningbo University, 57 Xingning Road, Ningbo, Zhejiang 315211, China.
authors: Jiangfang
authors: J
authors: Lian
authors: School of Medicine, Ningbo University, 818 Fenghua Road, Ningbo, Zhejiang 315211, China.
authors: Shiwei
authors: S
authors: Duan
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D003327:Coronary Disease / Q000235:genetics*; D003920:Diabetes Mellitus / Q000235:genetics; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D019947:Receptors, Interleukin-6 / Q000235:genetics*; D012044:Regression Analysis; D012907:Smoking / Q000009:adverse effects; D044366:Transition Temperature
chemical_list: D019947:Receptors, Interleukin-6