title: Acute liver failure caused by severe acute hepatitis B: a case series from a multi-center investigation.
abstract: BACKGROUND
  Few data can be available regarding acute liver failure (ALF) caused by severe acute hepatitis B up to now. This study aims to report such cases from China.
  
  
  RESULTS
  We conducted a multi-center investigation on ALF from 7 tertiary hospitals in different areas of China. A total of 11 patients with ALF caused by severe acute hepatitis B were finally identified. In these patients, there were 10 male and 1 female patients. As a serious complication, apparent hemorrhage occurred in 9 patients. Eventually, in these 11 patients, 4 survived and 7 died. 4 died of heavy bleeding, 2 died of systemic inflammatory response syndrome and 1 died of irreversible coma. No patients received liver transplantation.
  
  
  CONCLUSIONS
  ALF caused by severe acute hepatitis B is worthy of formal studies based on its rarity and severity.
authors: Chun-Ya
authors: CY
authors: Wang
authors: Clinical Trial Center, Liver Failure Therapy and Research Center, Beijing 302 Hospital (PLA 302 Hospital), No,100 of West Fourth Ring Middle Road, Beijing 100039, China. doczhaopan@126.com.
authors: Pan
authors: P
authors: Zhao
authors: Wei-Wei
authors: WW
authors: Liu
mesh_terms: D000328:Adult; D000368:Aged; D002681:China; D005260:Female; D006470:Hemorrhage / Q000453:epidemiology / Q000209:etiology; D006509:Hepatitis B / Q000150:complications* / Q000175:diagnosis*; D006801:Humans; D017114:Liver Failure, Acute / Q000150:complications / Q000175:diagnosis* / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D017678:Sex Distribution; D016019:Survival Analysis; D062606:Tertiary Care Centers