title: Bio-reduction of redox-sensitive albumin conjugates in FcRn-expressing cells.
abstract: Disulfide-containing IgG-, Fc-, or albumin-based prodrugs that rely on FcRn-trafficking by endothelial cells for prolonged circulation in the body might be hampered by premature bio-reduction processes during FcRn-mediated recycling events. A detailed bio-reduction analysis of redox-sensitive albumin conjugates in two FcRn-expressing cell lines has been performed. The obtained results indicate that the FcRn-mediated recycling pathway is not (or is only poorly) bio-reducing.
authors: Swiss Federal Institute of Technology Zurich (ETHZ), Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Vladimir-Prelog-Weg 1-5/10, 8093 Zurich (Switzerland).
authors: Lorine
authors: L
authors: Brülisauer
authors: Gina
authors: G
authors: Valentino
authors: Sakura
authors: S
authors: Morinaga
authors: Kübra
authors: K
authors: Cam
authors: Jens
authors: J
authors: Thostrup Bukrinski
authors: Marc A
authors: MA
authors: Gauthier
authors: Jean-Christophe
authors: JC
authors: Leroux
mesh_terms: D000418:Albumins / Q000737:chemistry*; D016503:Drug Delivery Systems; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D010084:Oxidation-Reduction; D011961:Receptors, Fc / Q000235:genetics*
chemical_list: D000418:Albumins; D015395:Histocompatibility Antigens Class I; D011961:Receptors, Fc; C100688:Fc receptor, neonatal
keywords: FcRn receptors; albumin; disulfide; drug delivery; reduction