title: Total osteocalcin in serum predicts testosterone level in male type 2 diabetes mellitus.
abstract: OBJECTIVE
  To investigate the relationship between total osteocalcin (total OC) and testosterone level in the serum of male patients with type 2 diabetes mellitus (T2DM).
  
  
  METHODS
  98 male T2DM were recruited in our cross-section study. Their anthropometric parameters were measured and body mass index (BMI) was calculated. Serum markers including glucose, insulin, HbA1c, testosterone, total OC and other bone metabolic markers were examined. Simple Pearson correlation and multiple regression analysis were performed.
  
  
  RESULTS
  Poor level of glucose control was found in the patients (HbA1c 9.19±2.53 and FPG 8.20±2.98). In simple Pearson correlation, total OC was positively related with testosterone (r=0.236, P=0.019), and this relation still existed after considering all the parameters of the patients (Model 1, 2 and 3).
  
  
  CONCLUSIONS
  In male patients with T2DM, total OC was positively correlated with testosterone, so total OC might predict the testosterone level in the serum.
authors: Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
authors: Ran
authors: R
authors: Cui
authors: Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
authors: Bin
authors: B
authors: Su
authors: Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
authors: Chunjun
authors: C
authors: Sheng
authors: Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
authors: Xiaoyun
authors: X
authors: Cheng
authors: Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
authors: Peng
authors: P
authors: Yang
authors: Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
authors: Le
authors: L
authors: Bu
authors: Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
authors: Hong
authors: H
authors: Li
authors: Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
authors: Jiying
authors: J
authors: Wang
authors: Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China ; Advanced Institute of Translational Medicine, Tongji University Shanghai 200092, China.
authors: Hui
authors: H
authors: Sheng
authors: Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
authors: Shen
authors: S
authors: Qu
keywords: Osteocalcin; testosterone; type 2 diabetes mellitus; undercarboxylated osteocalcin