title: Inflammation and insulin/IGF-1 resistance as the possible link between obesity and neurodegeneration.
abstract: Obesity is a growing epidemic that contributes to several brain disorders including Alzheimer's, Parkinson's, and Huntington's diseases. Obesity could promote these diseases through several different mechanisms. Here we review evidence supporting the involvement of two recently recognized factors linking obesity with neurodegeneration: the induction of pro-inflammatory cytokines and onset of insulin and insulin-like growth factor 1 (IGF-1) resistance. Excess peripheral pro-inflammatory mediators, some of which can cross the blood brain barrier, may trigger neuroinflammation, which subsequently exacerbates neurodegeneration. Insulin and IGF-1 resistance leads to weakening of neuroprotective signaling by these molecules and can contribute to onset of neurodegenerative diseases.
authors: Department of Biology, University of British Columbia Okanagan Campus, 3333 University Way, Kelowna, BC, V1V 1V7 Canada.
authors: Lindsay J
authors: LJ
authors: Spielman
authors: School of Health and Exercise Sciences, University of British Columbia Okanagan Campus, 3333 University Way, Kelowna, BC, V1V 1V7 Canada.
authors: Jonathan P
authors: JP
authors: Little
authors: Department of Biology, University of British Columbia Okanagan Campus, 3333 University Way, Kelowna, BC, V1V 1V7 Canada. Electronic address: andis.klegeris@ubc.ca.
authors: Andis
authors: A
authors: Klegeris
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000209:etiology*; D007333:Insulin Resistance; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000150:complications*; D009765:Obesity / Q000150:complications*
chemical_list: D016207:Cytokines; D007334:Insulin-Like Growth Factor I
keywords: Adipose tissue; Alzheimer's disease; Cytokines; Huntington's disease; Neuroinflammation; Parkinson's disease