title: Vitamin e is a nephroprotectant agent in male but not in female in a model of Cisplatin-induced nephrotoxicity.
abstract: Background. The role of gender for nephroprotectant agent such as vitamin E in cisplatin- (CP-) induced nephrotoxicity has not been documented yet. Methods. One group from each gender of Wistar rats received a single dose of CP (7 mg/kg; i.p) and was treated with vitamin E (1 g/kg/day) for 7 days, and they were compared with similar gender in the control group. Results. The serum levels of blood urea nitrogen (BUN) and creatinine (Cr) in male animals treated with CP was not different from the control group, but it was significantly different in the female rats (P < 0.05). The CP-induced damage intensity in male kidney tissue was not significantly different between the CP-treated and control groups, but this was not the case in female, indicating that the tissue damage in female is significantly different from the control group (P < 0.05). No significant difference in serum levels of magnesium (Mg), nitrite, malondialdehyde (MDA), and lactate dehydrogenase (LDH) was seen between the genders. Kidney weight and body weight changes were statistically significant in both genders (P < 0.05). Significant difference was observed in uterus weight between the two groups of female (P < 0.05). Conclusion. Vitamin E may prevent CP-induced nephrotoxicity in male, but possibly it has not such nephroprotectant effect in female.
authors: Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan 81745, Iran ; Deparment of Biology, Falavarjan Branch, Islamic Azad University, Isfahan 84515, Iran.
authors: Sima
authors: S
authors: Jilanchi
authors: Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan 81745, Iran ; Department of Physiology, Isfahan University of Medical Sciences, Isfahan 81745, Iran ; Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan 81745, Iran.
authors: Mehdi
authors: 0000-0002-9565-9187
authors: M
authors: Nematbakhsh
authors: Deparment of Biology, Falavarjan Branch, Islamic Azad University, Isfahan 84515, Iran.
authors: Mehrnoosh
authors: M
authors: Bahadorani
authors: Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan 81745, Iran ; Department of Clinical Pathology, Isfahan University of Medical Sciences, Isfahan 81745, Iran.
authors: Ardeshir
authors: A
authors: Talebi
authors: Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan 81745, Iran.
authors: Fatemeh
authors: F
authors: Eshraghi-Jazi
authors: Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan 81745, Iran.
authors: Azam
authors: A
authors: Mansouri
authors: Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan 81745, Iran ; Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan 81745, Iran.
authors: Farzaneh
authors: F
authors: Ashrafi