title: Protein detection on biotin-derivatized polyallylamine by optical microring resonators.
abstract: Silicon optical microring resonators (MRRs) are sensitive devices that can be used for biosensing. We present a novel biosensing platform based on the application of polyelectrolyte (PE) layers on such MRRs. The top PE layer was covalently labeled with biotin to ensure binding sites for antibodies via a streptavidin-biotin binding scheme. Monitoring the shift in the microring resonance wavelength allows real-time, highly sensitive detection of the biomolecular interaction.
authors: Daniela
authors: D
authors: Ullien
authors: Peter J
authors: PJ
authors: Harmsma
authors: Shahina M C
authors: SM
authors: Abdulla
authors: Bart M
authors: BM
authors: de Boer
authors: Duco
authors: D
authors: Bosma
authors: Ernst J R
authors: EJ
authors: Sudhölter
authors: Louis C P M
authors: LC
authors: de Smet
authors: Wolter F
authors: WF
authors: Jager
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D001710:Biotin / Q000032:analysis*; D011073:Polyamines / Q000032:analysis*; D012825:Silicon / Q000737:chemistry*; D019809:Streptavidin / Q000032:analysis*
chemical_list: D011073:Polyamines; C063994:polyallylamine; D001710:Biotin; D019809:Streptavidin; D012825:Silicon