title: Continuous flow synthesis of ketones from carbon dioxide and organolithium or Grignard reagents.
abstract: We describe an efficient continuous flow synthesis of ketones from CO2 and organolithium or Grignard reagents that exhibits significant advantages over conventional batch conditions in suppressing undesired symmetric ketone and tertiary alcohol byproducts. We observed an unprecedented solvent-dependence of the organolithium reactivity, the key factor in governing selectivity during the flow process. A facile, telescoped three-step-one-flow process for the preparation of ketones in a modular fashion through the in-line generation of organometallic reagents is also established.
authors: Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139 (USA).
authors: Jie
authors: J
authors: Wu
authors: Xiaoqing
authors: X
authors: Yang
authors: Zhi
authors: Z
authors: He
authors: Xianwen
authors: X
authors: Mao
authors: T Alan
authors: TA
authors: Hatton
authors: Timothy F
authors: TF
authors: Jamison
keywords: CO2 conversion; Grignard reactions; gas/liquid continuous flow; ketones; organic lithium reactivity