title: Combined reduced forced expiratory volume in 1 second (FEV1) and peripheral artery disease in sedentary elders with functional limitations.
abstract: OBJECTIVE
  Because they are potentially modifiable and may coexist, we evaluated the combined occurrence of a reduced forced expiratory volume in 1 second (FEV1) and peripheral artery disease (PAD), including its association with exertional symptoms, physical inactivity, and impaired mobility, in sedentary elders with functional limitations.
  
  
  METHODS
  Cross sectional.
  
  
  METHODS
  Lifestyle Interventions and Independence in Elder (LIFE) Study.
  
  
  METHODS
  A total of 1307 sedentary community-dwelling persons, mean age 78.9, with functional limitations (Short Physical Performance Battery [SPPB] <10).
  
  
  METHODS
  A reduced FEV1 was defined by a z-score less than -1.64 (<lower limit of normal), whereas PAD was defined by an ankle-brachial index less than 1.00. Exertional dyspnea was defined as moderate to severe (modified Borg index) immediately after a 400-meter walk test (400MWT). Exertional leg symptoms were established by the San Diego Claudication Questionnaire. Physical inactivity was evaluated by percent of accelerometry wear-time with activity less than 100 counts per minute (top quartile established high sedentary time). Mobility was evaluated by the 400MWT (gait speed <0.8 m/s defined as slow) and SPPB (≤ 7 defined moderate-to-severe mobility impairment).
  
  
  RESULTS
  A combined reduced FEV1 and PAD was established in 6.0% (78/1307) of participants. However, among those who had a reduced FEV1, 34.2% (78/228) also had PAD, whereas 20.8% (78/375) of those who had PAD also had a reduced FEV1. The 2 combined conditions were associated with exertional dyspnea (adjusted odds ratio [adjOR] 2.59 [1.20-5.60]) and slow gait speed (adjOR 3.15 [1.72-5.75]) but not with exertional leg symptoms, high sedentary time, and moderate-to-severe mobility impairment.
  
  
  CONCLUSIONS
  In sedentary community-dwelling elders with functional limitations, a reduced FEV1 and PAD frequently coexisted and, in combination, were strongly associated with exertional dyspnea and slow gait speed (a frailty indicator that increases the risk of deleterious outcomes).
authors: Clinical Epidemiology Research Center, VA Connecticut, West Haven, CT; Department of Medicine, Yale School of Medicine, New Haven, CT. Electronic address: carlos.fragoso@yale.edu.
authors: Carlos A
authors: CA
authors: Vaz Fragoso
authors: Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC.
authors: Fang-Chi
authors: FC
authors: Hsu
authors: Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC.
authors: Tina
authors: T
authors: Brinkley
authors: Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA; Klein Buendel, Inc., Golden, CO.
authors: Timothy
authors: T
authors: Church
authors: Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA; Section of Geriatrics, Department of Medicine, Boston University School of Medicine, Boston, MA.
authors: Christine K
authors: CK
authors: Liu
authors: Department of Aging and Geriatric Research, University of Florida, Gainesville, FL.
authors: Todd
authors: T
authors: Manini
authors: Department of Epidemiology and Medicine, University of Pittsburgh, Pittsburgh, PA.
authors: Anne B
authors: AB
authors: Newman
authors: Program on Prevention Outcomes and Practices, Stanford Prevention Research Center, Stanford School of Medicine, Stanford, CA.
authors: Randall S
authors: RS
authors: Stafford
authors: Northwestern University Feinberg School of Medicine, Chicago, IL.
authors: Mary M
authors: MM
authors: McDermott
authors: Department of Medicine, Yale School of Medicine, New Haven, CT.
authors: Thomas M
authors: TM
authors: Gill
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D005541:Forced Expiratory Volume; D005684:Gait / Q000502:physiology; D015577:Geriatric Assessment; D006801:Humans; D008297:Male; D051346:Mobility Limitation; D016491:Peripheral Vascular Diseases / Q000503:physiopathology*; D057185:Sedentary Behavior; D013147:Spirometry
keywords: FEV1; mobility; peripheral artery disease; sedentary