title: Does nephrotoxicity exist in pediatric epileptic patients on valproate or carbamazepine therapy?
abstract: The aim of this study was to investigate the effects of valproate and carbamazepine, on renal glomerular and tubular functions. The patient group comprised 54 children with new-onset epilepsy treated with valproate (n = 30) and carbamazepine (n = 24). Twenty-six healthy children were in the control group. The serum creatinine and cystatin C levels and urinary excretion of N-acetyl-β-d-glucosaminidase (NAG) levels were measured and the glomerular filtration rate (GFR) was estimated. Serum creatinine and cystatin C concentrations were not different between patients and controls. The glomerular filtration rate of the patient groups were higher than those of the control group. Thus, both drugs probably lead to glomerular hyperfiltration and toxicity for glomerular functions. However, urinary N-acetyl-β-d-glucosaminidase/creatinine levels were significantly higher in patients receiving only valproate (6.1 ± 5). The difference between carbamazepine and control groups was not significant for urinary N-acetyl-β-d-glucosaminidase/creatinine levels. Our data suggest that valproate has adverse effects on renal tubular functions.
authors: Department of Pediatric Neurology, Gazi University Faculty of Medicine, Ankara, Turkey cengizhavali@gmail.com.
authors: Cengiz
authors: C
authors: Havali
authors: Department of Pediatric Neurology, Gazi University Faculty of Medicine, Ankara, Turkey.
authors: Kıvılcım
authors: K
authors: Gücüyener
authors: Department of Pediatric Nephrology, Gazi University Faculty of Medicine, Ankara, Turkey.
authors: Necla
authors: N
authors: Buyan
authors: Department of Pediatric Neurology, Dr. Behçet Uz Children's Hospital, Izmir, Turkey.
authors: Ünsal
authors: Ü
authors: Yılmaz
authors: Department of Pediatric Neurology, Gazi University Faculty of Medicine, Ankara, Turkey.
authors: Esra
authors: E
authors: Gürkaş
authors: Department of Biochemistry, Gazi University Faculty of Medicine, Ankara, Turkey.
authors: Özlem
authors: Ö
authors: Gülbahar
authors: Department of Pediatric Neurology, Gazi University Faculty of Medicine, Ankara, Turkey.
authors: Ercan
authors: E
authors: Demir
authors: Department of Pediatric Neurology, Gazi University Faculty of Medicine, Ankara, Turkey.
authors: Ayşe
authors: A
authors: Serdaroğlu
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000009:adverse effects*; D002220:Carbamazepine / Q000009:adverse effects*; D016022:Case-Control Studies; D002648:Child; D003404:Creatinine / Q000097:blood; D055316:Cystatin C / Q000097:blood; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006596:Hexosaminidases / Q000652:urine; D006801:Humans; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis / Q000652:urine; D008297:Male; D018709:Statistics, Nonparametric; D014635:Valproic Acid / Q000009:adverse effects*
chemical_list: D000927:Anticonvulsants; D055316:Cystatin C; D002220:Carbamazepine; D014635:Valproic Acid; D003404:Creatinine; D006596:Hexosaminidases
keywords: antiepileptic drugs; glomerular toxicity; tubulopathy