title: Lack of influence of serum magnesium levels on overall mortality and cardiovascular outcomes in patients with advanced chronic kidney disease.
abstract: Background. Low serum magnesium has been associated with an increased cardiovascular risk in the general population and in dialysis patients. Our aim was to analyze the influence of serum magnesium on overall mortality and cardiovascular outcomes in patients with advanced CKD not yet on dialysis. Methods. Seventy patients with CKD stages 4 and 5 were included. After a single measurement of s-magnesium, patients were followed a mean of 11 months. Primary end-point was death of any cause, and secondary end-point was the occurrence of fatal or nonfatal CV events. Results. Basal s-magnesium was within normal range (2.1 ± 0.3 mg/dL), was lower in men (P = 0.008) and in diabetic patients (P = 0.02), and was not different (P = 0.2) between patients with and without cardiopathy. Magnesium did not correlate with PTH, calcium, phosphate, albumin, inflammatory parameters (CRP), and cardiac (NT-proBNP) biomarkers but correlated inversely (r = -0.23; P = 0.052) with the daily dose of loop diuretics. In univariate and multivariate Cox proportional hazard models, magnesium was not an independent predictor for overall mortality or CV events. Conclusions. Our results do not support that serum magnesium can be an independent predictor for overall mortality or future cardiovascular events among patients with advanced CKD not yet on dialysis.
authors: Nephrology Service, Hospital Severo Ochoa, Avenida Orellana s/n, Leganés 28911, Madrid, Spain.
authors: Olimpia
authors: 0000-0001-5122-3018
authors: O
authors: Ortega
authors: Nephrology Service, Hospital Severo Ochoa, Avenida Orellana s/n, Leganés 28911, Madrid, Spain.
authors: Isabel
authors: I
authors: Rodriguez
authors: Nephrology Service, Hospital Severo Ochoa, Avenida Orellana s/n, Leganés 28911, Madrid, Spain.
authors: Gabriela
authors: G
authors: Cobo
authors: Nephrology Service, Hospital Severo Ochoa, Avenida Orellana s/n, Leganés 28911, Madrid, Spain.
authors: Julie
authors: J
authors: Hinostroza
authors: Nephrology Service, Hospital Severo Ochoa, Avenida Orellana s/n, Leganés 28911, Madrid, Spain.
authors: Paloma
authors: P
authors: Gallar
authors: Nephrology Service, Hospital Severo Ochoa, Avenida Orellana s/n, Leganés 28911, Madrid, Spain.
authors: Carmen
authors: C
authors: Mon
authors: Nephrology Service, Hospital Severo Ochoa, Avenida Orellana s/n, Leganés 28911, Madrid, Spain.
authors: Milagros
authors: M
authors: Ortiz
authors: Nephrology Service, Hospital Severo Ochoa, Avenida Orellana s/n, Leganés 28911, Madrid, Spain.
authors: Juan Carlos
authors: JC
authors: Herrero
authors: Nephrology Service, Hospital Severo Ochoa, Avenida Orellana s/n, Leganés 28911, Madrid, Spain.
authors: Cristina
authors: C
authors: Di Gioia
authors: Nephrology Service, Hospital Severo Ochoa, Avenida Orellana s/n, Leganés 28911, Madrid, Spain.
authors: Aniana
authors: A
authors: Oliet
authors: Nephrology Service, Hospital Severo Ochoa, Avenida Orellana s/n, Leganés 28911, Madrid, Spain.
authors: Ana
authors: A
authors: Vigil