title: Evaluation of the effectiveness of endoscopic retrograde cholangiopancreatography in patients with perihilar cholangiocarcinoma and its effect on development of cholangitis.
abstract: Objective. We aimed to determine the effectiveness of endoscopic retrograde cholangiopancreatography (ERCP) in patients with inoperable perihilar cholangiocarcinoma and establish the incidence of cholangitis development following ERCP. Material and Method. This retrospective study enrolled patients diagnosed with inoperable perihilar cholangiocarcinoma who underwent endoscopic drainage (stenting) with ERCP. Patients were evaluated for development of cholangitis and the effectiveness of ERCP. The procedure was considered successful if bilirubin level fell more than 50% within 7 days after ERCP. Results. Post-ERCP cholangitis developed in 40.7% of patients. Cholangitis development was observed among 39.4% of patients with effective ERCP and in 60.6% of patients with ineffective ERCP. Development of cholangitis was significantly more common in the group with ineffective ERCP compared to the effective ERCP group (P = 0.001). The average number of ERCP procedures was 2.33 ± 0.89 among patients developing cholangitis and 1.79 ± 0.97 in patients without cholangitis. The number of ERCP procedures was found to be significantly higher among patients developing cholangitis compared to those without cholangitis (P = 0.012). Conclusion. ERCP may not provide adequate biliary drainage in some of the patients with perihilar cholangiocarcinoma and also it is a procedure associated an increased risk of cholangitis.
authors: Department of Gastroenterology, Atatürk Training and Research Hospital, İzmir Katip Çelebi University, İzmir Atatürk Eğitim ve Araştırma Hastanesi, Karabağlar, 35160 İzmir, Turkey.
authors: Serkan
authors: S
authors: Ipek
authors: Department of Gastroenterology, Atatürk Training and Research Hospital, İzmir Katip Çelebi University, İzmir Atatürk Eğitim ve Araştırma Hastanesi, Karabağlar, 35160 İzmir, Turkey.
authors: Emrah
authors: E
authors: Alper
authors: Department of Gastroenterology, Atatürk Training and Research Hospital, İzmir Katip Çelebi University, İzmir Atatürk Eğitim ve Araştırma Hastanesi, Karabağlar, 35160 İzmir, Turkey.
authors: Cem
authors: C
authors: Cekic
authors: Department of Gastroenterology, Erzurum Regional and Research Hospital, 25140 Erzurum, Turkey.
authors: Serkan
authors: S
authors: Cerrah
authors: Department of Gastroenterology, Atatürk Training and Research Hospital, İzmir Katip Çelebi University, İzmir Atatürk Eğitim ve Araştırma Hastanesi, Karabağlar, 35160 İzmir, Turkey.
authors: Mahmut
authors: 0000-0002-7444-4275
authors: M
authors: Arabul
authors: Department of Gastroenterology, Atatürk Training and Research Hospital, İzmir Katip Çelebi University, İzmir Atatürk Eğitim ve Araştırma Hastanesi, Karabağlar, 35160 İzmir, Turkey.
authors: Fatih
authors: 0000-0002-1002-7202
authors: F
authors: Aslan
authors: Department of Gastroenterology, Atatürk Training and Research Hospital, İzmir Katip Çelebi University, İzmir Atatürk Eğitim ve Araştırma Hastanesi, Karabağlar, 35160 İzmir, Turkey.
authors: Belkis
authors: B
authors: Unsal