title: Sex-specific biatrial volumetric measurements obtained with use of multidetector computed tomography in subjects with and without coronary artery disease.
abstract: Atrial volumetric measurement has proven clinical implications. Advances in cardiac imaging, notably the precision enabled by multidetector computed tomography (MDCT), herald the need for new criteria of what constitutes normal volumetric measurements. With use of 64-slice MDCT, we compared the atrial volumes in healthy individuals with those in individuals with coronary artery disease. By means of manual segmentation, we measured biatrial volume in 686 participants who underwent retrospective electrocardiographic-gated MDCT angiographic evaluation. The study population included a control group of 203 persons with no cardiac abnormalities, and a study group of 483 patients with obstructive coronary artery disease. All variables were compared between men and women and between the groups. We found a significant difference in left atrial end-systolic and end-diastolic volumes between men and women in the control group (P <0.05); however, right atrial volumes were similar. In comparison with the entire control group, the coronary artery disease group had significantly higher left atrial volume, significantly lower right atrial stroke volume, and significantly lower biatrial ejection fraction, except for left atrial ejection fraction in men. Right atrial volume and left atrial stroke volume were not significantly different. The results imply that a sex-specific reference value is necessary for left atrial volumetric evaluation, and that left atrial volume and biatrial ejection fraction (excluding left atrial ejection fraction in men) might be useful during diagnosis and prognosis in patients who have coronary artery disease.
authors: Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502.
authors: Matthew J
authors: MJ
authors: Budoff
authors: Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502.
authors: Sandeep R
authors: SR
authors: Pagali
authors: Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502.
authors: Yasmin S
authors: YS
authors: Hamirani
authors: Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502.
authors: Andy
authors: A
authors: Chen
authors: Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502.
authors: Gordon
authors: G
authors: Cheu
authors: Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502.
authors: Yanlin
authors: Y
authors: Gao
authors: Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502.
authors: Dong
authors: D
authors: Li
authors: Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502.
authors: SongShou
authors: S
authors: Mao
mesh_terms: D000328:Adult; D000368:Aged; D016279:Atrial Function, Left; D016280:Atrial Function, Right; D002140:California / Q000453:epidemiology; D055424:Cardiac-Gated Imaging Techniques; D006332:Cardiomegaly / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000503:physiopathology; D017023:Coronary Angiography / Q000379:methods* / Q000592:standards; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000503:physiopathology; D004562:Electrocardiography; D005260:Female; D054624:Health Status Disparities; D006325:Heart Atria / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography / Q000592:standards; D011237:Predictive Value of Tests; D015995:Prevalence; D011857:Radiographic Image Interpretation, Computer-Assisted; D012016:Reference Values; D012189:Retrospective Studies; D012737:Sex Factors
keywords: Atrial function; cardiac volume/physiology; coronary angiography/methods; heart atria/pathology/ultrasonography; image interpretation, computer-assisted/methods; imaging, three-dimensional; predictive value of tests; sensitivity and specificity; tomography, x-ray computed/methods/utilization