title: Design and green synthesis of 2-(diarylalkyl)aminobenzothiazole derivatives and their dual activities as angiotensin converting enzyme inhibitors and calcium channel blockers.
abstract: A series of novel 2-(diarylalkyl)aminobenzothiazoles were designed based on commercial synthetic calcium channel blockers (CCBs) and angiotensin converting enzyme (ACE) inhibitors. Which are further modified based on the natural products which are angiotensin converting enzyme (ACE) inhibitors. Completely green protocol was developed for their synthesis. As they are initially designed based on CCBs, they were screened for their ACE inhibition property believing that almost all the compounds will be CCBs. Out of 42 compounds two lead molecules were identified as ACE inhibitors, which were further screened for CCB. As expected both were identified as CCBs with different selectivity over ACE inhibition. Their selectivity over ACE and CCB can be used to treat resistant hypertension.
authors: Crop Protection Chemicals Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India.
authors: Praveen Kumar
authors: PK
authors: Kalavagunta
authors: Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India.
authors: Pankaj K
authors: PK
authors: Bagul
authors: Crop Protection Chemicals Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India; Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India.
authors: Anvesh
authors: A
authors: Jallapally
authors: Crop Protection Chemicals Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India. Electronic address: srinivask@iict.res.in.
authors: Srinivas
authors: S
authors: Kantevari
authors: Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India. Electronic address: skbanerjee@iict.res.in.
authors: Sanjay K
authors: SK
authors: Banerjee
authors: Crop Protection Chemicals Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India. Electronic address: ravindra@iict.res.in.
authors: Narender
authors: N
authors: Ravirala
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D052160:Benzothiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D002121:Calcium Channel Blockers / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D060326:Chemistry Techniques, Synthetic; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D055772:Green Chemistry Technology; D008297:Male; D062105:Molecular Docking Simulation; D007703:Peptidyl-Dipeptidase A / Q000737:chemistry / Q000378:metabolism; D011487:Protein Conformation; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D052160:Benzothiazoles; D002121:Calcium Channel Blockers; D007703:Peptidyl-Dipeptidase A; C005465:benzothiazole
keywords: 2-Aminobenzothiazole; ACE inhibitors; Calcium channel blockers; Diarylalkylamine; Green synthesis; Resistant hypertension