title: Multivalvular Replacement and Ventricular Arrhythmias in a Female Child With Congenital Polyvalvular Disease.
abstract: We report the clinical course of a female child with a normal karyotype and chromosomal microarray who presented as an infant with clinical findings consistent with congenital polyvalvular disease (CPVD). This clinical entity describes patients with multiple congenitally dysplastic valves, often showing nodular or cystic malformation in at least two cardiac valves. This patient then developed medically refractory multifocal ventricular arrhythmia and required radiofrequency ablation at seven months of age. She had good tachycardia control but became symptomatic with right heart failure related to progressive tricuspid, pulmonary, and mitral valve dysfunction necessitating multivalvular replacement at 21 months of age.
authors: Division of Cardiology, Department of Pediatrics, Children's Hospital Colorado, University of Colorado, Aurora, CO, USA benjamin.goot@childrenscolorado.org.
authors: Benjamin H
authors: BH
authors: Goot
authors: Division of Cardiovascular Surgery, Department of Pediatrics, Children's Hospital Colorado, University of Colorado, Aurora, CO, USA.
authors: James
authors: J
authors: Jaggers
authors: Department of Pathology, Children's Hospital Colorado, University of Colorado, Aurora, CO, USA.
authors: Miran Rhee
authors: MR
authors: Anagnost
authors: Division of Cardiology, Department of Pediatrics, Children's Hospital Colorado, University of Colorado, Aurora, CO, USA.
authors: Kathryn K
authors: KK
authors: Collins
mesh_terms: D001021:Aortic Valve / Q000002:abnormalities / Q000601:surgery*; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006349:Heart Valve Diseases / Q000151:congenital / Q000175:diagnosis / Q000601:surgery*; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006801:Humans; D007231:Infant, Newborn; D008943:Mitral Valve / Q000002:abnormalities / Q000601:surgery*; D017180:Tachycardia, Ventricular / Q000151:congenital*
keywords: congenital polyvalvular disease; mitral valve replacement; pulmonary valve replacement; tricuspid valve replacement; trisomy 18; ventricular tachycardia