title: Clinicopathological features and survival in young Taiwanese women with endometrial carcinoma.
abstract: OBJECTIVE
  The aim of this study is to compare the clinicopathological features and survival of young women with endometrial cancer (aged <50 years) with those of older women with endometrial cancer (aged ≥50 years).
  
  
  METHODS
  We conducted a retrospective cohort study of patients with histologically confirmed endometrial cancer treated at the Taipei Veterans General Hospital from 2001 to 2010.
  
  
  RESULTS
  One hundred forty-six patients (28.5%) were aged younger than 50 years at diagnosis. The median follow-up was 36.5 months (range, 0.9-121.7 months). Low body mass index (P < 0.001), nulliparity (P < 0.001), less medical illness (P < 0.001), synchronous primary ovarian cancer (P = 0.001), endometrioid type (P = 0.005), low tumor grade (P < 0.001), no para-aortic lymph node involvement (P < 0.047), less myometrial invasion (P < 0.001), and no vascular space invasion (P = 0.001) were common among the younger women compared with the older women. There were significant differences in the disease-free survival (P = 0.006) and overall survival (P = 0.004) between the 2 groups. In the multivariate Cox model, advanced stage had an effect on both disease-free survival (P = 0.004) and overall survival (P = 0.050).
  
  
  CONCLUSIONS
  Nulliparity, body mass index less than or equal to 23 kg/m, endometrioid type, low-grade tumor, synchronous primary ovarian cancer, and favorable survival were common among the younger women.
authors: *Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, Taipei Veterans General Hospital; †Department of Obstetrics and Gynecology, National Yang-Ming University; ‡Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China.
authors: Hei-Yu
authors: HY
authors: Lau
authors: Yi-Jen
authors: YJ
authors: Chen
authors: Ming-Shyen
authors: MS
authors: Yen
authors: Kuan-Chong
authors: KC
authors: Chao
authors: Ru-Fen
authors: RF
authors: Chen
authors: Shu-O
authors: SO
authors: Yeh
authors: Nae-Fang
authors: NF
authors: Twu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D016889:Endometrial Neoplasms / Q000401:mortality* / Q000473:pathology* / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D013624:Taiwan