title: Regioselective synthesis of benzimidazolones via cascade C-N coupling of monosubstituted ureas.
abstract: A direct method for the regioselective construction of benzimidazolones is reported wherein a single palladium catalyst is employed to couple monosubstituted urea substrates with differentially substituted 1,2-dihaloaromatic systems. In this method, the catalyst is able to promote a cascade of two discrete chemoselective C-N bond-forming processes that allows the highly selective and predictable formation of complex heterocycles from simple, readily available starting materials.
authors: Department of Chemistry, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.
authors: Johannes B
authors: JB
authors: Ernst
authors: Nicholas E S
authors: NE
authors: Tay
authors: Nathan T
authors: NT
authors: Jui
authors: Stephen L
authors: SL
authors: Buchwald
mesh_terms: D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D014508:Urea / Q000737:chemistry*
chemical_list: D001562:Benzimidazoles; C014353:benzimidazolone; D010165:Palladium; D014508:Urea