title: Enteral nutrition and total parenteral nutrition components in the course of total parenteral nutrition-associated cholestasis in neonatal necrotizing enterocolitis.
abstract: BACKGROUND
  Newborns with necrotizing enterocolitis (NEC) are at high risk for the development of total parenteral nutritional-associated cholestasis (TPNAC). Patients with NEC were evaluated to determine risk factors for development of TPNAC and predictors of resolution. We hypothesized that there are additional factors relating to the timing of enteral nutrition or TPN components that effect development and persistence of TPNAC in patients with NEC that may be altered to decrease the chance of progression to liver failure.
  
  
  METHODS
  This was a retrospective chart review of NEC patients from 2001 to 2010. TPNAC was defined as direct bilirubin ≥2 mg/dL, the level used for cholestasis in neonatal studies relating to TPNAC.
  
  
  RESULTS
  Of 178 patients with NEC, 96 developed TPNAC, and in 27 TPNAC had resolved by discharge. Days of TPN did not affect TPNAC resolution by discharge (P = 1.0). TPNAC was less likely to occur in patients with body weights >1,500 g, enteral nutrition within the first week of life, no infection, fewer TPN days, and lesser hospital stay (P < .01). There were many factors affecting resolution of cholestasis. Enteral nutrition within 6 days of birth decreased development of TPNAC (P < .01), and resumption of enteral nutrition within 3 weeks after NEC diagnosis increased the resolution of cholestasis (P < .01). No component of TPN was important for the development or resolution of cholestasis.
  
  
  CONCLUSIONS
  Of the factors that effect development and resolution of TPNAC in NEC, the ones that we can alter include early enteral feeds and surveillance for infection.
authors: Department of Pediatric Surgery, Children's Hospital of Michigan, Detroit, MI. Electronic address: mveenstr@dmc.org.
authors: Michelle
authors: M
authors: Veenstra
authors: Department of Pediatric Surgery, Children's Hospital of Michigan, Detroit, MI.
authors: Logan
authors: L
authors: Danielson
authors: Department of Pediatric Surgery, Children's Hospital of Michigan, Detroit, MI.
authors: Evan
authors: E
authors: Brownie
authors: Department of Pharmacy, Children's Hospital of Michigan, Detroit, MI.
authors: May
authors: M
authors: Saba
authors: Division of Neonatal and Perinatal Medicine, Children's Hospital of Michigan, Detroit, MI.
authors: Girija
authors: G
authors: Natarajan
authors: Department of Pediatric Surgery, Children's Hospital of Michigan, Detroit, MI; Department of Surgery, Wayne State University School of Medicine, Detroit, MI.
authors: Michael
authors: M
authors: Klein
mesh_terms: D002779:Cholestasis / Q000209:etiology*; D004750:Enteral Nutrition / Q000009:adverse effects*; D020345:Enterocolitis, Necrotizing / Q000150:complications* / Q000628:therapy*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010289:Parenteral Nutrition, Total / Q000009:adverse effects*; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors