title: Wound healing reaction: A switch from gestation to senescence.
abstract: The repair of wounded tissue during postnatal life could be associated with the upregulation of some functions characteristic of the initial phases of embryonic development. The focusing of these recapitulated systemic functions in the interstitial space of the injured tissue is established through a heterogeneous endothelial barrier which has excretory-secretory abilities which in turn, would induce a gastrulation-like process. The repair of adult tissues using upregulated embryonic mechanisms could explain the universality of the inflammatory response against injury, regardless of its etiology. However, the early activation after the injury of embryonic mechanisms does not always guarantee tissue regeneration since their long-term execution is mediated by the host organism.
authors: Maria-Angeles Aller, Jaime Arias, Surgery Department, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.
authors: Maria-Angeles
authors: MA
authors: Aller
authors: Maria-Angeles Aller, Jaime Arias, Surgery Department, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.
authors: Jose-Ignacio
authors: JI
authors: Arias
authors: Maria-Angeles Aller, Jaime Arias, Surgery Department, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.
authors: Luis-Alfonso
authors: LA
authors: Arraez-Aybar
authors: Maria-Angeles Aller, Jaime Arias, Surgery Department, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.
authors: Carlos
authors: C
authors: Gilsanz
authors: Maria-Angeles Aller, Jaime Arias, Surgery Department, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.
authors: Jaime
authors: J
authors: Arias
keywords: Amniotic; Embryonic mechanisms; Repair; Vitelline; Wound healing