title: Coriander alleviates 2,4-dinitrochlorobenzene-induced contact dermatitis-like skin lesions in mice.
abstract: Contact dermatitis (CD) is a pattern of inflammatory responses in the skin that occurs through contact with external factors. The clinical picture is a polymorphic pattern of skin inflammation characterized by a wide range of clinical features, including itching, redness, scaling, and erythema. Coriandrum sativum L. (CS), commonly known as coriander, is a member of the Apiaceae family and is cultivated throughout the world for its nutritional and culinary values. Linoleic acid and linolenic acid in CS have various pharmacological activities. However, no study of the inhibitory effects of CS on CD has been reported. In this study, we demonstrated the protective effect of CS against 2,4-dinitrochlorobenzene-induced CD-like skin lesions. CS, at doses of 0.5-1%, applied to the dorsal skin inhibited the development of CD-like skin lesions. Moreover, the Th2-mediated inflammatory cytokines, immunoglobulin E, tumor necrosis factor-α, interferon-γ, interleukin (IL)-1, IL-4, and IL-13, were significantly reduced. In addition, CS increased the levels of total glutathione and heme oxygenase-1 protein. Thus, CS can inhibit the development of CD-like skin lesions in mice by regulating immune mediators and may be an effective alternative therapy for contact diseases.
authors: 1 Department of Life and Nanopharmaceutical Science, Graduate School and Kyung Hee East-West Pharmaceutical Research Institute, Kyung Hee University , Seoul, Korea.
authors: Gunhyuk
authors: G
authors: Park
authors: Hyo Geun
authors: HG
authors: Kim
authors: Soonmin
authors: S
authors: Lim
authors: Wonil
authors: W
authors: Lee
authors: Yeomoon
authors: Y
authors: Sim
authors: Myung Sook
authors: MS
authors: Oh
mesh_terms: D000818:Animals; D028526:Coriandrum / Q000737:chemistry*; D003877:Dermatitis, Contact / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D004137:Dinitrochlorobenzene / Q000633:toxicity*; D006801:Humans; D018793:Interleukin-13 / Q000235:genetics / Q000276:immunology; D015847:Interleukin-4 / Q000235:genetics / Q000276:immunology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010936:Plant Extracts / Q000008:administration & dosage*; D012867:Skin / Q000187:drug effects / Q000276:immunology / Q000473:pathology
chemical_list: D004137:Dinitrochlorobenzene; D018793:Interleukin-13; D010936:Plant Extracts; D015847:Interleukin-4
keywords: 2,4-dinitrochlorobenzene; Coriandrum sativum L.; Th2-mediated cytokines; contact dermatitis-like skin; scratching behavior