title: Efficacy and acceptability of a mifepristone-misoprostol combined regimen for early induced abortion among women in Mexico City.
abstract: OBJECTIVE
  To evaluate the experience of women receiving mifepristone-misoprostol for early induced abortion in public sector facilities in the Federal District of Mexico City.
  
  
  METHODS
  An open-label prospective study was conducted with 1000 pregnant women who sought induced abortion with a pregnancy of up to 63days of gestation, as measured from the date of their last menstrual period. The study was conducted in three public sector healthcare facilities: two secondary level hospitals and one primary care clinic. Women ingested 200mg mifepristone on day 1, followed by 800μg buccal misoprostol 24hours later, and they returned for follow-up on day 8. The primary outcome was complete abortion without recourse to surgical intervention.
  
  
  RESULTS
  A total of 971 women received mifepristone-misoprostol and were included in the analysis for efficacy of treatment. The overall efficacy of the combined medical abortion regimen studied was 97.3% (n=945); the success rate did not vary significantly by gestational age (95.9%-100%; P=0.449). Most women (n=922, 95.0%) had a successful induced abortion with only one dose of misoprostol.
  
  
  CONCLUSIONS
  The combined mifepristone and buccal misoprostol regimen was found to be highly effective and acceptable among Mexican women. www.ClinicalTrials.gov: NCT00386282.
authors: Gynuity Health Projects, New York, USA. Electronic address: mpena@gynuity.org.
authors: Melanie
authors: M
authors: Peña
authors: Gynuity Health Projects, New York, USA.
authors: Ilana G
authors: IG
authors: Dzuba
authors: Secretariat of Health, Mexico City, Mexico.
authors: Patricio Sanhueza
authors: PS
authors: Smith
authors: Secretariat of Health, Mexico City, Mexico.
authors: Luis Jorge Arellano
authors: LJ
authors: Mendoza
authors: Independent consultant, Mexico City, Mexico.
authors: Manuel
authors: M
authors: Bousiéguez
authors: Secretariat of Health, Mexico City, Mexico.
authors: María Laura García
authors: ML
authors: Martínez
authors: Secretariat of Health, Mexico City, Mexico.
authors: Ranulfo Ríos
authors: RR
authors: Polanco
authors: Secretariat of Health, Mexico City, Mexico.
authors: Antonio Eduardo Flores
authors: AE
authors: Villalón
authors: Gynuity Health Projects, New York, USA.
authors: Beverly
authors: B
authors: Winikoff
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage* / Q000009:adverse effects; D000021:Abortifacient Agents, Steroidal / Q000008:administration & dosage* / Q000009:adverse effects; D000028:Abortion, Induced / Q000009:adverse effects / Q000379:methods* / Q000706:statistics & numerical data; D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008800:Mexico; D008875:Middle Aged; D015735:Mifepristone / Q000008:administration & dosage* / Q000009:adverse effects; D016595:Misoprostol / Q000008:administration & dosage* / Q000009:adverse effects; D010342:Patient Acceptance of Health Care; D011446:Prospective Studies; D016896:Treatment Outcome; D014505:Urban Population; D055815:Young Adult
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D000021:Abortifacient Agents, Steroidal; D016595:Misoprostol; D015735:Mifepristone
keywords: Acceptability; Combined regimen; Efficacy; Medical abortion; Mexico; Mifepristone; Misoprostol