title: Novel immobilization of a quaternary ammonium moiety on keratin fibers for medical applications.
abstract: This paper introduces a new approach for immobilizing a quaternary ammonium moiety on a keratinous substrate for enhanced medical applications. The method involves the generation of thiols by controlled reduction of cystine disulfide bonds in the keratin, followed by reaction with [2-(acryloyloxy)ethyl]trimethylammonium chloride through thiol-ene click chemistry. The modified substrate was characterized with Raman and infrared spectroscopy, and assessed for its antibacterial efficacy and other performance changes. The results have demonstrated that the quaternary ammonium moiety has been effectively attached onto the keratin structure, and the resultant keratin substrate exhibits a multifunctional effect including antibacterial and antistatic properties, improved liquid moisture management property, improved dyeability and a non-leaching characteristic of the treated substrate.
authors: CSIRO Materials Science and Engineering, P.O. Box 21, Belmont, Victoria 3216, Australia; College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China.
authors: Dan
authors: D
authors: Yu
authors: CSIRO Materials Science and Engineering, P.O. Box 21, Belmont, Victoria 3216, Australia. Electronic address: jackie.cai@csiro.au.
authors: Jackie Y
authors: JY
authors: Cai
authors: Institute for Frontier Materials, Deakin University, Geelong 3216, Australia.
authors: Xin
authors: X
authors: Liu
authors: CSIRO Materials Science and Engineering, P.O. Box 21, Belmont, Victoria 3216, Australia.
authors: Jeffrey S
authors: JS
authors: Church
authors: School of Fashion and Textiles, RMIT University, 25 Dawson Street, Brunswick, Victoria 3056, Australia.
authors: Lijing
authors: L
authors: Wang
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D007633:Keratins / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D014935:Wool / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D000644:Quaternary Ammonium Compounds; D007633:Keratins
keywords: Antibacterial; Antistatic; Immobilization; Keratin fiber; Quaternary ammonium; Thiol-ene