title: [Release kinetics of single pellets and the multi-pellet system of tamsulosin hydrochloride sustained release pellets].
abstract: The release behavior of single pellet was investigated by LC/MS/MS method with tamsulosin hydrochloride (TSH) as the model drug of the research and then the pellets were divided into four groups according to the drug loading. Comparison of dissolution profiles of each group and capsule were performed using f1 and f2 factor methods to study the difference and similarity. The release profiles of single pellet, each group and capsule were analyzed using principle component analysis (PCA). The particle system was built through Matlab to get the target release profile. The result of this research demonstrated the release behavior of single pellet correlated well with the drug loading. While the dissolution profile of capsule as a reference, the similarity factor of dissolution profiles of the lower drug loading groups were 62.2, 67.1, 53.9, respectively and, 43.3 for highest drug loading group. The particle systems with different pellet distribution and same release profiles were built through release behavior of single pellet. It is of significance to investigate the release behavior of single pellets for studying the release regularity of multiple-unit drug delivery system.
authors: Shuo
authors: S
authors: Yang
authors: Cai-Fen
authors: CF
authors: Wang
authors: Xue
authors: X
authors: Li
authors: Ying
authors: Y
authors: Li
authors: Xian-Zhen
authors: XZ
authors: Yin
authors: Tao
authors: T
authors: Guo
authors: Ji-Wen
authors: JW
authors: Zhang
authors: Jun
authors: J
authors: He
authors: Li-Xin
authors: LX
authors: Sun
mesh_terms: D002214:Capsules; D002626:Chemistry, Pharmaceutical; D002853:Chromatography, Liquid; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D065546:Drug Liberation; D025341:Principal Component Analysis; D013449:Sulfonamides / Q000008:administration & dosage* / Q000737:chemistry*; D000077409:Tamsulosin; D053719:Tandem Mass Spectrometry; D013678:Technology, Pharmaceutical
chemical_list: D002214:Capsules; D003692:Delayed-Action Preparations; D013449:Sulfonamides; D000077409:Tamsulosin