title: A case of peritoneal TB causing renal failure in a patient with rheumatoid arthritis and initial negative PPD after treatment with infliximab.
abstract: Opportunistic infection and reactivation of latent infection has been reported with use of monoclonal TNF alpha antibodies used for treatment of severe rheumatoid arthritis. We present a case of peritoneal tuberculosis (TB) causing renal failure secondary to ureteral constriction in a patient who had been treated with infliximab for rheumatoid arthritis. We suggest that physicians should be aware of the increased risk of false negative and false positive TST and IGRA among patients treated with monoclonal TNF alpha antibodies and should regularly look for usual and unusual symptoms of TB in this patient population.
authors: Department of Medicine, Maimonides Medical Center , NY , USA .
authors: Abhishek
authors: A
authors: Sharma
authors: Divyanshu
authors: D
authors: Dubey
authors: Kalyan
authors: K
authors: Janga
authors: Sheldon
authors: S
authors: Greenberg
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D000368:Aged; D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D018501:Antirheumatic Agents / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D000069285:Infliximab; D014395:Peritonitis, Tuberculous / Q000139:chemically induced / Q000150:complications*; D014517:Ureteral Obstruction / Q000150:complications
chemical_list: D000911:Antibodies, Monoclonal; D018501:Antirheumatic Agents; D000069285:Infliximab
keywords: Monoclonal TNF alpha antibodies; renal failure; tuberculosis