title: Highly regioselective lithiation of pyridines bearing an oxetane unit by n-butyllithium.
abstract: The first regioselective ortho-lithiation at the 4-position of simple pyridine derivatives containing a 3-oxetane unit has been achieved using n-butyllithium as base. Electrophilic quenching of the resulting lithio species provides a rapid access to a broad range of new functionalized pyridine oxetane building blocks.
authors: Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK. gr354@cam.ac.uk.
authors: Guy
authors: G
authors: Rouquet
authors: David C
authors: DC
authors: Blakemore
authors: Steven V
authors: SV
authors: Ley
mesh_terms: D004988:Ethers, Cyclic / Q000737:chemistry*; D008094:Lithium / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*
chemical_list: D004988:Ethers, Cyclic; D009942:Organometallic Compounds; D011725:Pyridines; C434823:n-butyllithium; D008094:Lithium; C005287:oxetane