title: Association between metabolic factors and chronic hepatitis B virus infection.
abstract: There are limited data regarding the relationship between chronic hepatitis B virus (HBV) infection and metabolic factors. This article aims to highlight the link of metabolic factors with hepatitis B surface antigen (HBsAg) serostatus, HBV load, and HBV-related hepatocellular carcinoma (HCC). Although HBsAg-positive serostatus was positively correlated with a high risk of metabolic syndrome in students, chronic HBV-infected individuals have high serum adiponectin levels. The androgen pathway in HBV carriers with a low body mass index is more triggered which leads to enhanced HBV replication. High HBV load was inversely associated with obesity in hepatitis B e antigen (HBeAg)-seropositive HBV carriers; while in HBeAg-seronegative HBV carriers, high HBV load was inversely related to hypertriglyceridemia rather than obesity. For overweight and obese HBV-infected patients, high HBV load was positively associated with serum adiponectin levels. Several large cohort studies have revealed a positive link of diabetes with incidence of HBV-related HCC. However, the association between incidence of HCC and metabolic factors other than diabetes is still inconclusive. More long-term prospective studies should elucidate the association of chronic HBV infection and its outcomes with metabolic factors in clinical practice.
authors: Chien-Hsieh Chiang, Kuo-Chin Huang, Department of Family Medicine, National Taiwan University Hospital and College of Medicine, Taipei 100, Taiwan.
authors: Chien-Hsieh
authors: CH
authors: Chiang
authors: Chien-Hsieh Chiang, Kuo-Chin Huang, Department of Family Medicine, National Taiwan University Hospital and College of Medicine, Taipei 100, Taiwan.
authors: Kuo-Chin
authors: KC
authors: Huang
mesh_terms: D052242:Adiponectin / Q000097:blood; D000818:Animals; D015415:Biomarkers / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000821:virology; D003920:Diabetes Mellitus / Q000097:blood / Q000175:diagnosis / Q000821:virology*; D050171:Dyslipidemias / Q000097:blood / Q000175:diagnosis / Q000821:virology*; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000276:immunology / Q000378:metabolism / Q000472:pathogenicity*; D019694:Hepatitis B, Chronic / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000821:virology*; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000821:virology; D009765:Obesity / Q000097:blood / Q000175:diagnosis / Q000821:virology*; D012307:Risk Factors; D019562:Viral Load; D014779:Virus Replication
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D006514:Hepatitis B Surface Antigens
keywords: Adiponectin; Diabetes; Hepatitis B surface antigen; Hepatitis B viral load; Hepatocellular carcinoma; Obesity