title: Metadherin, p50, and p65 expression in epithelial ovarian neoplasms: an immunohistochemical study.
abstract: NF-κB signaling promotes cancer progression in a large number of malignancies. Metadherin, a coactivator of the NF-κB transcription complex, was recently identified to regulate different signaling pathways that are closely related to cancer. We assessed the immunohistochemical expression of p50, p65, and metadherin in 30 ovarian carcinomas, 15 borderline ovarian tumours, and 31 benign ovarian cystadenomas. Ovarian carcinomas exhibited significantly higher expression of all 3 markers compared to benign ovarian tumours. Borderline ovarian tumours demonstrated significantly higher expression for all 3 markers compared to benign cystadenomas. Ovarian carcinomas demonstrated significantly higher expression of p50 and metadherin compared to borderline ovarian tumours, whereas no significant difference was noted in p65 expression between ovarian carcinomas and borderline ovarian tumours. There was a strong correlation with the expression levels of p50, p65, and metadherin, whereas no correlation was observed with either grade or stage. Strong p50, p65, and metadherin expression was associated with a high probability to distinguish ovarian carcinomas over borderline and benign ovarian tumours, as well as borderline ovarian tumours over benign ovarian neoplasms. A gradual increase in the expression of these molecules is noted when moving across the spectrum of ovarian carcinogenesis, from borderline ovarian tumours to epithelial carcinomas.
authors: Department of Anatomy, School of Medicine, University of Patras, 26500 Patras, Greece.
authors: Ioanna
authors: 0000-0003-4393-7517
authors: I
authors: Giopanou
authors: Department of Anatomy, School of Medicine, University of Patras, 26500 Patras, Greece.
authors: Vasiliki
authors: V
authors: Bravou
authors: Department of Medical Oncology, Imperial College, London W6 8RF, UK.
authors: Panagiotis
authors: P
authors: Papanastasopoulos
authors: Department of Anatomy, School of Medicine, University of Patras, 26500 Patras, Greece.
authors: Ioannis
authors: I
authors: Lilis
authors: Department of Pathology, "Agios Andreas" Hospital, 26335 Patras, Greece.
authors: Panagiotis
authors: P
authors: Aroukatos
authors: Department of Anatomy, School of Medicine, University of Patras, 26500 Patras, Greece.
authors: Dionysios
authors: D
authors: Papachristou
authors: Department of Pathology, Elena Venizelou Hospital, 11521 Athens, Greece.
authors: Sophia
authors: S
authors: Kounelis
authors: Department of Anatomy, School of Medicine, University of Patras, 26500 Patras, Greece.
authors: Helen
authors: H
authors: Papadaki
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015815:Cell Adhesion Molecules / Q000096:biosynthesis*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008565:Membrane Proteins; D008875:Middle Aged; D052002:NF-kappa B p50 Subunit / Q000096:biosynthesis*; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology; D016601:RNA-Binding Proteins; D012189:Retrospective Studies; D051996:Transcription Factor RelA / Q000096:biosynthesis*
chemical_list: D015815:Cell Adhesion Molecules; C483039:MTDH protein, human; D008565:Membrane Proteins; D052002:NF-kappa B p50 Subunit; C489548:NFKB1 protein, human; D009363:Neoplasm Proteins; C498143:RELA protein, human; D016601:RNA-Binding Proteins; D051996:Transcription Factor RelA