title: One-pot synthesis of polysubstituted 3-acylpyrroles by cooperative catalysis.
abstract: One-pot syntheses of polysubstituted 3-acylpyrroles from readily available unsaturated ketones and N-substituted propargylated amines have been developed. An aza-Michael/alkyne carbocyclization cascade, by cooperative catalysis using pyrrolidine and a copper salt, followed by oxidation in situ gave 3-acylpyrroles, which were also transformed further to functionalized, highly substituted 3-acylpyrroles.
authors: Chemistry and Chemical Bioengineering Unit, Okinawa Institute of Science and Technology Graduate University, 1919-1 Tancha, Onna, Okinawa 904-0495, Japan. ftanaka@oist.jp.
authors: Hai-Lei
authors: HL
authors: Cui
authors: Fujie
authors: F
authors: Tanaka
mesh_terms: D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D005663:Furans / Q000138:chemical synthesis / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry*; D013696:Temperature
chemical_list: D005663:Furans; D004364:Pharmaceutical Preparations; D011758:Pyrroles