title: Bottlenecks in proteomics.
abstract: Mass spectrometry (MS) is the core for advanced methods in proteomic experiments. When effectively used, proteomics may provide extensive information about proteins and their post-translational modifications, as well as their interaction partners. However, there are also many problems that one can encounter during a proteomic experiment, including, but not limited to sample preparation, sample fractionation, sample analysis, data analysis & interpretation, and biological significance. Here we discuss some of the problems that researchers should be aware of when performing a proteomic experiment.
authors: Biochemistry & Proteomics Group, Department of Chemistry & Biomolecular Science, Clarkson University, 8 Clarkson Avenue, Potsdam, NY, 13699-5810, USA.
authors: Armand G
authors: AG
authors: Ngounou Wetie
authors: Devon A
authors: DA
authors: Shipp
authors: Costel C
authors: CC
authors: Darie
mesh_terms: D013058:Mass Spectrometry / Q000379:methods*; D040901:Proteomics / Q000379:methods*