title: Indolent systemic mastocytosis in a patient with ileocolitis.
abstract: Systemic mastocytosis is a clonal disorder of the mast cell and its progenitor cell. It is a rare disorder with unknown incidence in Greece, with an estimate of 2 cases per year in Great Britain. We present a case of an asymptomatic, 72-year-old man who was found to have ileocolitis on endoscopy. Histology revealed mast cells in lamina propria >15 HPF and biochemistry showed high levels of serum total tryptase. Molecular testing was positive for the mutation Asp816Val in exon 17 ofc-kit gene. The patient met one major and two minor criteria for the diagnosis of systemic indolent mastocytosis (according to WHO classification). He has been treated prophylactically with H1- and H2-histamine receptor antagonists and remains asymptomatic.
authors: Gastroenterology Department of 1 I.K.A. Hospital - Present address: Gastroenterology Clinic, General and Oncology Hospital of Kifissia Agioi Anargyroi (Georgios Chrysakopoulos, Stelios Papasavvas, Andreas Koutsoumpas, Georgios Mylonas, Vassilios Tzias), Athens, Greece.
authors: Georgios
authors: G
authors: Chrysakopoulos
authors: Pathology Laboratory of G.H. Sismanoglion (Maria Demonakou), Athens, Greece.
authors: Maria
authors: M
authors: Demonakou
authors: Gastroenterology Department of 1 I.K.A. Hospital - Present address: Gastroenterology Clinic, General and Oncology Hospital of Kifissia Agioi Anargyroi (Georgios Chrysakopoulos, Stelios Papasavvas, Andreas Koutsoumpas, Georgios Mylonas, Vassilios Tzias), Athens, Greece.
authors: Stelios
authors: S
authors: Papasavvas
authors: Gastroenterology Department of 1 I.K.A. Hospital - Present address: Gastroenterology Clinic, General and Oncology Hospital of Kifissia Agioi Anargyroi (Georgios Chrysakopoulos, Stelios Papasavvas, Andreas Koutsoumpas, Georgios Mylonas, Vassilios Tzias), Athens, Greece.
authors: Andreas
authors: A
authors: Koutsoumpas
authors: Gastroenterology Department of 1 I.K.A. Hospital - Present address: Gastroenterology Clinic, General and Oncology Hospital of Kifissia Agioi Anargyroi (Georgios Chrysakopoulos, Stelios Papasavvas, Andreas Koutsoumpas, Georgios Mylonas, Vassilios Tzias), Athens, Greece.
authors: Georgios
authors: G
authors: Mylonas
authors: Gastroenterology Department of 1 I.K.A. Hospital - Present address: Gastroenterology Clinic, General and Oncology Hospital of Kifissia Agioi Anargyroi (Georgios Chrysakopoulos, Stelios Papasavvas, Andreas Koutsoumpas, Georgios Mylonas, Vassilios Tzias), Athens, Greece.
authors: Vassilios
authors: V
authors: Tzias
keywords: Mastocytosis; asymptomatic; colitis; ileitis; indolent