title: Resistance to fluoroquinolones and methicillin in ophthalmic isolates of Staphylococcus pseudintermedius from companion animals.
abstract: Resistance to fluoroquinolones and methicillin was determined for 49 ophthalmic isolates of Staphylococcus pseudintermedius from dogs with and without ophthalmic disease. Resistance was observed for ciprofloxacin (40.8%), ofloxacin (38.8%), enrofloxacin (38.8%), levofloxacin (34.7%), and moxifloxacin (4.1%). Eighteen isolates, 16 of which were resistant to oxacillin, were mecA-positive. Nine of the 16 oxacillin-resistant mecA-positive S. pseudintermedius isolates were resistant to more than one fluoroquinolone and 2 isolates were resistant to 5 fluoroquinolones. The frequency of mecA gene occurrence and fluoroquinolone resistance was twice as high among S. pseudintermedius isolates derived from dogs with ophthalmic disease compared with isolates for dogs without ophthalmic disease. The high prevalence of methicillin and fluoroquinolone resistance in S. pseudintermedius from dogs with ophthalmic disease is a concern.
authors: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea (Kang, Chae, Lee, Yoo, Park); Department of Veterinary Microbiology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea (Yoon).
authors: Min-Hee
authors: MH
authors: Kang
authors: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea (Kang, Chae, Lee, Yoo, Park); Department of Veterinary Microbiology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea (Yoon).
authors: Min-Joo
authors: MJ
authors: Chae
authors: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea (Kang, Chae, Lee, Yoo, Park); Department of Veterinary Microbiology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea (Yoon).
authors: Jang-Won
authors: JW
authors: Yoon
authors: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea (Kang, Chae, Lee, Yoo, Park); Department of Veterinary Microbiology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea (Yoon).
authors: So-Young
authors: SY
authors: Lee
authors: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea (Kang, Chae, Lee, Yoo, Park); Department of Veterinary Microbiology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea (Yoon).
authors: Jong-Hyun
authors: JH
authors: Yoo
authors: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea (Kang, Chae, Lee, Yoo, Park); Department of Veterinary Microbiology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea (Yoon).
authors: Hee-Myung
authors: HM
authors: Park
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D004283:Dog Diseases / Q000382:microbiology*; D004285:Dogs; D024901:Drug Resistance, Multiple, Bacterial; D015818:Eye Infections, Bacterial / Q000382:microbiology*; D024841:Fluoroquinolones / Q000494:pharmacology*; D008712:Methicillin / Q000494:pharmacology*; D057805:Pets; D013203:Staphylococcal Infections / Q000382:microbiology / Q000662:veterinary*; D057790:Staphylococcus saprophyticus / Q000145:classification / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D008712:Methicillin