title: Maternal hypertriglyceridemia: A link between maternal overweight-obesity and macrosomia in gestational diabetes.
abstract: OBJECTIVE
  Infants born from overweight and obese mothers with glucose-controlled gestational diabetes (GDM) tend to be large-for-gestational age (LGA). It is hypothesized that this is due to an excessive rise in maternal triglyceride levels.
  
  
  METHODS
  Two-hundred and seventy nine singleton GDM pregnancies were divided into three groups according to prepregnancy BMI: normal weight (BMI = 20-24.9; n = 128), overweight (BMI = 25-29.9; n = 105), and obese (BMI ≥ 30; n = 46). Individual z-scores (ZS) of maternal triglycerides and of newborn weight (NWZS) were calculated as deviations from published 50th percentiles. Mean z-scores (MZS) were the average of triglyceride ZSs. MZS of triglycerides, HbA1c and NWZS were compared. Variables are expressed as mean ± SD.
  
  
  RESULTS
  In the three groups respectively: LGA (%) = 10.1%, 19.0% and 30.4% (P = 0.015). Birth weight (g) = 3274.2 ± 501.3, 3342.4 ± 620.2 and 3366.3±644.7 (RSPEARMAN  = 0.111, P = 0.027). HbA1c (%) = 5.2 ± 0.39, 5.3 ± 0.50 and 5.4 ± 0.47 (P = NS). Triglyceride MZS = 1.20 ± 1.13, 1.52 ± 1.37 and 1.62 ± 1.42 (RSPEARMAN = 0.116, P = 0.024). Correlations between triglyceride MZS and NWZS were, respectively: r = 0.12 (P = NS), r = 0.42 (P <0.001), and r = 0.47 (P < 0.001).
  
  
  CONCLUSIONS
  In overweight and obese GDM mothers, maternal triglycerides are partially responsible for LGA infants despite good maternal glucose control during pregnancy.
authors: Department of Obstetrics & Gynecology, College of Medicine, Pontificia Universidad Católica de Chile, Alameda, 340, Santiago, Chile; Department of Nutrition, College of Medicine, Pontificia Universidad Católica de Chile, Alameda, 340, Santiago, Chile.
authors: Pablo R
authors: PR
authors: Olmos
authors: Attilio
authors: A
authors: Rigotti
authors: Dolores
authors: D
authors: Busso
authors: Loni
authors: L
authors: Berkowitz
authors: José L
authors: JL
authors: Santos
authors: Gisella R
authors: GR
authors: Borzone
authors: José A
authors: JA
authors: Poblete
authors: Claudio
authors: C
authors: Vera
authors: Cristián
authors: C
authors: Belmar
authors: Denisse
authors: D
authors: Goldenberg
authors: Bárbara
authors: B
authors: Samith
authors: Ana M
authors: AM
authors: Acosta
authors: Manuel
authors: M
authors: Escalona
authors: Ian
authors: I
authors: Niklitschek
authors: Jorge R
authors: JR
authors: Mandiola
authors: Nicolás
authors: N
authors: Mertens
mesh_terms: D000328:Adult; D001835:Body Weight; D016640:Diabetes, Gestational; D005260:Female; D005320:Fetal Macrosomia / Q000209:etiology*; D005865:Gestational Age; D006801:Humans; D015228:Hypertriglyceridemia / Q000150:complications*; D007231:Infant, Newborn; D009765:Obesity; D011247:Pregnancy; D011248:Pregnancy Complications; D011446:Prospective Studies