title: Association between co-stimulatory molecule gene polymorphism and acute rejection of allograft.
abstract: Co-stimulatory molecules play important roles in T cell-mediated immune response and transplantation. Numerous epidemiological studies have evaluated the association between CD28, CTLA-4 gene variant and allograft rejection. However, the results of these studies on the association remain conflicting. The main purpose of this study was to integrate previous results and explore whether the CD28 IVS3 +17T/C variant, CTLA-4, CD86 and PDCD1 gene polymorphisms were associated with allograft rejection susceptibility. PubMed and Embase (before 2014-3-25), were searched for studies on the relationship of CD28, CTLA-4, CD86 and PDCD1 gene polymorphisms and the incidence of allograft rejection susceptibility. Eligible articles were included for data extraction. The main outcome was the frequency of co-stimulate molecule gene polymorphisms between rejection and non-rejection populations. Comparison of the distribution of SNP was mainly performed using Review Manager 5.0. The odds ratio (OR) and its 95% confidence interval (95% CI) were used to assess the strength of association. Significant associations of the CD28 IVS3 +17T/C variant with acute allograft rejection susceptibility were found (CC +CT/TT OR, 1.45; 95% CI, 1.08-1.94; P=0.01). Also we found an association of the CD28 IVS3 +17T/C variant with kidney allograft rejection cases (CC +CT/TT OR, 1.72; 95% CI, 1.19-2.49; P=0.004) and (C allele OR, 1.74; 95% CI, 1.11-2.75; P=0.02), but not established for liver allograft rejection cases (CC +CT/TT OR, 1.19; 95% CI, 0.47-2.98; P=0.72) and (C allele OR, 0.96; 95% CI, 0.67-1.39; P=0.84). And we found an association of the CD86 +1057G/A variant with non-allograft rejection cases (AA +AG/GG OR, 0.35; 95% CI, 0.14-0.85; P=0.02). This meta-analysis demonstrates that the CD28 IVS3 +17T/C variant might increase acute allograft rejection risk in kidney transplant but not in liver transplant, and there was an association between CD86 +1057G/A variant and reduced acute rejection risk. Further studies will be needed to confirm our findings.
authors: Pharmacy Department of Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
authors: Fei-Fei
authors: FF
authors: Han
authors: Hepatobiliary Surgery Department of Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
authors: Hua
authors: H
authors: Fan
authors: Pharmacy Department of Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
authors: Zi-Hui
authors: ZH
authors: Wang
authors: Pharmacy Department of Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
authors: Guang-Run
authors: GR
authors: Li
authors: Pharmacy Department of Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
authors: Ya-Li
authors: YL
authors: Lv
authors: Pharmacy Department of Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
authors: Li-Li
authors: LL
authors: Gong
authors: Pharmacy Department of Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
authors: He
authors: H
authors: Liu
authors: Hepatobiliary Surgery Department of Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China. Electronic address: heqiang349@sina.com.
authors: Qiang
authors: Q
authors: He
authors: Pharmacy Department of Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China. Electronic address: hongllh@126.com.
authors: Li-Hong
authors: LH
authors: Liu
mesh_terms: D064591:Allografts; D051940:B7-2 Antigen / Q000235:genetics*; D018106:CD28 Antigens / Q000235:genetics*; D060908:CTLA-4 Antigen / Q000235:genetics*; D006084:Graft Rejection / Q000235:genetics* / Q000276:immunology; D006801:Humans; D016030:Kidney Transplantation; D016031:Liver Transplantation; D020641:Polymorphism, Single Nucleotide; D061026:Programmed Cell Death 1 Receptor / Q000235:genetics*; D013601:T-Lymphocytes / Q000276:immunology; D014184:Transplantation, Homologous
chemical_list: D051940:B7-2 Antigen; D018106:CD28 Antigens; C497964:CD86 protein, human; D060908:CTLA-4 Antigen; C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor
keywords: Acuter allograft rejection; CD86 +1057G/A variant; CTLA-4 +49 A/G variant; Co-stimulatory molecule gene golymorphism CD28 IVS3 +17T/C variant