title: Strategies for desymmetrising trehalose to synthesise trehalose glycolipids.
abstract: The desymmetrisation and regioselective protection of trehalose are major challenges in the chemical synthesis of biologically essential trehalose glycolipids. We reviewed the literature on desymmetrising trehalose to synthesise trehalose glycolipids and highlighted an efficient regioselective 6-O-phosphorylation method that can be applied to synthesise asymmetric trehalose glycolipids.
authors: Chemical Biology and Molecular Biophysics Program, Taiwan International Graduate Program (TIGP), Academia Sinica, Taipei 115, Taiwan.
authors: Chia-Hui
authors: CH
authors: Wu
authors: Cheng-Chung
authors: CC
authors: Wang
mesh_terms: D002236:Carbohydrate Conformation; D005947:Glucose / Q000737:chemistry; D006017:Glycolipids / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D014199:Trehalose / Q000737:chemistry*
chemical_list: D006017:Glycolipids; D014199:Trehalose; D005947:Glucose