title: Asymmetric epoxidation of alkenes and benzylic hydroxylation with P450tol monooxygenase from Rhodococcus coprophilus TC-2.
abstract: P450tol monooxygenase was discovered as a unique and highly enantioselective enzyme for asymmetric epoxidation of some terminal alkenes containing electron-withdrawing groups and benzylic hydroxylation of several ethylbenzenes giving the corresponding useful and valuable products, such as (R)-2- and 3-substituted styrene oxides, (S)-4-substituted styrene oxides, and (S)-benzylic alcohols, in high ee.
authors: Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore. chelz@nus.edu.sg.
authors: Aitao
authors: A
authors: Li
authors: Shuke
authors: S
authors: Wu
authors: Joseph P
authors: JP
authors: Adams
authors: Radka
authors: R
authors: Snajdrova
authors: Zhi
authors: Z
authors: Li
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D001555:Benzene Derivatives / Q000737:chemistry*; D004852:Epoxy Compounds / Q000737:chemistry*; D004926:Escherichia coli / Q000201:enzymology; D006900:Hydroxylation; D010105:Oxygenases / Q000737:chemistry*; D012240:Rhodococcus / Q000201:enzymology*; D013329:Structure-Activity Relationship; D013343:Styrenes / Q000737:chemistry
chemical_list: D000475:Alkenes; D001555:Benzene Derivatives; D004852:Epoxy Compounds; D013343:Styrenes; D010105:Oxygenases