title: Antiartherosclerotic effects of plant flavonoids.
abstract: Atherosclerosis is the process of hardening and narrowing the arteries. Atherosclerosis is generally associated with cardiovascular diseases such as strokes, heart attacks, and peripheral vascular diseases. Since the usage of the synthetic drug, statins, leads to various side effects, the plants flavonoids with antiartherosclerotic activity gained much attention and were proven to reduce the risk of atherosclerosis in vitro and in vivo based on different animal models. The flavonoids compounds also exhibit lipid lowering effects and anti-inflammatory and antiatherogenic properties. The future development of flavonoids-based drugs is believed to provide significant effects on atherosclerosis and its related diseases. This paper discusses the antiatherosclerotic effects of selected plant flavonoids such as quercetin, kaempferol, myricetin, rutin, naringenin, catechin, fisetin, and gossypetin.
authors: Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
authors: Shamala
authors: 0000-0003-1485-6339
authors: S
authors: Salvamani
authors: Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
authors: Baskaran
authors: B
authors: Gunasekaran
authors: Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
authors: Noor Azmi
authors: 0000-0003-0057-9932
authors: NA
authors: Shaharuddin
authors: Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
authors: Siti Aqlima
authors: 0000-0002-7625-3704
authors: SA
authors: Ahmad
authors: Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
authors: Mohd Yunus
authors: MY
authors: Shukor
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000188:drug therapy*; D005419:Flavonoids / Q000627:therapeutic use*; D006801:Humans; D010944:Plants / Q000737:chemistry*
chemical_list: D005419:Flavonoids