title: Formation of oligonucleotide-gated silica shell-coated Fe₃O₄-Au core-shell nanotrisoctahedra for magnetically targeted and near-infrared light-responsive theranostic platform.
abstract: A new multifunctional nanoparticle to perform a near-infrared (NIR)-responsive remote control drug release behavior was designed for applications in the biomedical field. Different from the previous studies in formation of Fe3O4-Au core-shell nanoparticles resulting in a spherical morphology, the heterostructure with polyhedral core and shell was presented with the truncated octahedral Fe3O4 nanoparticle as the core over a layer of trisoctahedral Au shell. The strategy of Fe3O4@polymer@Au was adopted using poly-l-lysine as the mediate layer, followed by the subsequent seeded growth of Au nanoparticles to form a Au trisoctahedral shell. Fe3O4@Au trisoctahedra possess high-index facets of {441}. To combine photothermal and chemotherapy in a remote-control manner, the trisoctahedral core-shell Fe3O4@Au nanoparticles were further covered with a mesoporous silica shell, yielding Fe3O4@Au@mSiO2. The bondable oligonucleotides (referred as dsDNA) were used as pore blockers of the mesoporous silica shell that allowed the controlled release, resulting in a NIR-responsive DNA-gated Fe3O4@Au@mSiO2 nanocarrier. Taking advantage of the magnetism, remotely triggered drug release was facilitated by magnetic attraction accompanied by the introduction of NIR radiation. DNA-gated Fe3O4@Au@mSiO2 serves as a drug control and release carrier that features functions of magnetic target, MRI diagnosis, and combination therapy through the manipulation of a magnet and a NIR laser. The results verified the significant therapeutic effects on tumors with the assistance of combination therapy consisting of magnetic guidance and remote NIR control.
authors: Department of Chemistry, Center for Micro/Nano Science and Technology and Advanced Optoelectronic Technology Center, National Cheng Kung University , Tainan 701, Taiwan.
authors: Wei-Peng
authors: WP
authors: Li
authors: Pei-Yi
authors: PY
authors: Liao
authors: Chia-Hao
authors: CH
authors: Su
authors: Chen-Sheng
authors: CS
authors: Yeh
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use; D004317:Doxorubicin / Q000008:administration & dosage / Q000627:therapeutic use; D004337:Drug Carriers / Q000138:chemical synthesis; D016503:Drug Delivery Systems; D005290:Ferric Compounds / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008280:Magnetics; D051379:Mice; D008819:Mice, Nude; D049329:Nanostructures / Q000737:chemistry*; D009368:Neoplasm Transplantation; D009841:Oligonucleotides / Q000737:chemistry*; D010316:Particle Size; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D005290:Ferric Compounds; D009841:Oligonucleotides; C000499:ferric oxide; D006046:Gold; D012822:Silicon Dioxide; D004317:Doxorubicin