title: Opioid use is associated with decreased quality of life in patients with Crohn's disease.
abstract: OBJECTIVE
  Quality of life is an important consideration in the management of patients with Crohn's disease. Previous studies suggest that Crohn's disease patients using opioids may have decreased quality of life and increased risk of mortality. Our aim was to determine the association between health-related quality of life (HRQoL) and opioid use in patients with Crohn's disease while controlling for disease severity.
  
  
  METHODS
  We conducted a cross-sectional study recruiting Crohn's disease patients at our center. Disease activity was measured using the Harvey-Bradshaw Index (HBI), and HRQoL was measured using the Inflammatory Bowel Disease Questionnaire (IBDQ).
  
  
  RESULTS
  We enrolled 38 Crohn's disease patients using opioids and 62 patients not using opioids. Patients using opioids had an increased duration of disease (median 18.5 vs. 9 years, P = 0.005), increased surgeries related to Crohn's disease (median 3 vs. 0, P < 0.001), and increased prednisone use (29% vs. 11.3%, P = 0.03). Patients using opioids had increased disease activity (median HBI score 9.0 vs. 3.0, P < 0.001). Quality of life was lower in patients using opioids (mean IBDQ score 109.3 vs. 162.9, P < 0.001). This finding was significant when controlling for HBI scores, number of previous surgeries, and prednisone use (P = 0.003).
  
  
  CONCLUSIONS
  Opioid use in Crohn's disease patients appears to be associated with disease activity and severity. HRQoL is markedly decreased in patients using opioids and this association is significant even when controlling for variables reflecting disease severity. Our findings suggest that Crohn's disease patients using opioids are likely to be significantly impacted by their disease.
authors: Department of Medicine, Western University, Victoria Hospital, London, ON, Canada.
authors: David
authors: D
authors: Sanford
authors: Patrick
authors: P
authors: Thornley
authors: Anouar
authors: A
authors: Teriaky
authors: Nilesh
authors: N
authors: Chande
authors: James
authors: J
authors: Gregor
mesh_terms: D000046:Academic Medical Centers; D000328:Adult; D000367:Age Factors; D000701:Analgesics, Opioid / Q000009:adverse effects* / Q000627:therapeutic use; D059350:Chronic Pain / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D003424:Crohn Disease / Q000150:complications / Q000188:drug therapy* / Q000523:psychology*; D003430:Cross-Sectional Studies; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009864:Ontario; D010147:Pain Measurement / Q000187:drug effects; D011788:Quality of Life; D018570:Risk Assessment; D012720:Severity of Illness Index; D012737:Sex Factors
chemical_list: D000701:Analgesics, Opioid