title: Optical coherence tomographic observation of morphological features of neointimal tissue after drug-eluting stent implantation.
abstract: OBJECTIVE
  The impacts of different time courses and the degree of neointimal growth on neointimal morphology have not yet been sufficiently investigated. Therefore, we evaluated the morphological features of neointimal tissue after drug-eluting stent (DES) implantation using optical coherence tomography (OCT).
  
  
  METHODS
  The morphological features of neointimal tissue in stented segments with a maximal percentage of cross-sectional area (CSA) stenosis of neointima were evaluated in 507 DES-treated lesions with >100 μm mean neointimal thickness on follow-up OCT. Neointimal tissue was categorized as homogeneous, heterogeneous, layered, or neoatherosclerotic.
  
  
  RESULTS
  In lesions with <50% of neointimal CSA stenosis, homogeneous neointima (68.2%) was predominant, followed by heterogeneous neointima (14.1%) and layered neointima (14.1%). In lesions with ≥50% of neointimal CSA stenosis, layered neointima was most frequently observed (68.3%), followed by neoatherosclerotic neointima (25.2%). In subgroup analysis of lesions with ≥50% of neointimal CSA stenosis, 89.5% of the lesions with a stent age<30 months were layered neointima, while 62.3% of the lesions with a stent age≥30 months were neoatherosclerotic neointima.
  
  
  CONCLUSIONS
  This study suggests that the OCT-detected morphology of DES neointimal tissue was different according to the follow-up time course and degree of neointimal hyperplasia.
authors: Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors: Seung-Yul
authors: SY
authors: Lee
authors: Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors: Dong-Ho
authors: DH
authors: Shin
authors: Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors: Jung-Sun
authors: JS
authors: Kim
authors: Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors: Byeong-Keuk
authors: BK
authors: Kim
authors: Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors: Young-Guk
authors: YG
authors: Ko
authors: Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors: Donghoon
authors: D
authors: Choi
authors: Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea. ; Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea.
authors: Yangsoo
authors: Y
authors: Jang
authors: Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea. mkhong61@yuhs.ac; Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea.
authors: Myeong-Ki
authors: MK
authors: Hong
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000601:surgery*; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D058426:Neointima / Q000175:diagnosis*; D041623:Tomography, Optical Coherence / Q000379:methods*
keywords: Optical coherence tomography; coronary artery disease; stent