title: Clinical patterns and outcome of early-onset inflammatory bowel disease.
abstract: We sought to determine whether extremely-early-onset childhood inflammatory bowel disease (age <6 years; 20 ulcerative colitis [UC], 8 Crohn disease [CD], 2 indeterminate, sequentially diagnosed) was clinically more severe than in older children (6-17 years; 19 UC, 39 CD, 2 indeterminate). Early-onset UC was marked by less abdominal pain at presentation, but an aggressive course with a significant reduction in weight-for-age, increased use of immunosuppressants, and more surgery. Children with early-onset CD were more likely to have bloody stools at presentation and an isolated colitis. This study supports the suggestion that inflammatory bowel disease phenotype differs in early-onset disease.
authors: Department of Gastroenterology and Clinical Nutrition, Royal Children's Hospital, Parkville, Victoria, Australia.
authors: Oren
authors: O
authors: Ledder
authors: Anthony G
authors: AG
authors: Catto-Smith
authors: Mark R
authors: MR
authors: Oliver
authors: George
authors: G
authors: Alex
authors: Donald J S
authors: DJ
authors: Cameron
authors: Winita
authors: W
authors: Hardikar
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D017668:Age of Onset; D001835:Body Weight; D002675:Child, Preschool; D003092:Colitis / Q000209:etiology; D003093:Colitis, Ulcerative / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D003424:Crohn Disease / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D010641:Phenotype; D011379:Prognosis; D012720:Severity of Illness Index
chemical_list: D007166:Immunosuppressive Agents