title: Involvement of cAMP- and IKK-2-dependent signal pathways in the growth capacity of mesenchymal progenitor cells under the influence of basic fibroblast growth factor.
abstract: We studied the role of cAMP- and IKK-2-dependent pathways under conditions of functional stimulation of mesenchymal progenitor cells by basic fibroblast growth factor. An adenylate cyclase inhibitor 2',5'-dideoxyadenosine had no effect on functional activity of early (primitive) mesenchymal precursors. This agent produced a stimulatory effect on proliferation of stromal precursor cells. Mitotic activity of mesenchymal progenitor cells was shown to decrease after treatment with a specific blocker of the IKK-2 kinase-inhibitor complex.
authors: E. D. Gol'dberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia, zgn@pharm.tsu.ru.
authors: G N
authors: GN
authors: Zyuz'kov
authors: V V
authors: VV
authors: Zhdanov
authors: M G
authors: MG
authors: Danilets
authors: E V
authors: EV
authors: Udut
authors: L A
authors: LA
authors: Miroshnichenko
authors: A A
authors: AA
authors: Ligacheva
authors: E V
authors: EV
authors: Simanina
authors: A V
authors: AV
authors: Chaikovskii
authors: E S
authors: ES
authors: Trofimova
authors: M Yu
authors: MY
authors: Minakova
authors: V V
authors: VV
authors: Udut
authors: A M
authors: AM
authors: Dygai
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000378:metabolism*; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D051550:I-kappa B Kinase / Q000378:metabolism*; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism*; D051379:Mice; D044968:Regenerative Medicine; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D016222:Fibroblast Growth Factor 2; D000242:Cyclic AMP; D051550:I-kappa B Kinase; C496562:Ikbkb protein, mouse