title: Identification of novel inhibitors that disrupt STAT3-DNA interaction from a γ-AApeptide OBOC combinatorial library.
abstract: From a γ-AApeptide-based one-bead-one-compound (OBOC) combinatorial library, we identified γ-AApeptides that can selectively inhibit STAT3-DNA interaction and suppress the expression levels of STAT3 target genes in intact cells. Our results demonstrate that in addition to the SH2 domain, the DNA binding domain of STAT3 is targetable for the development of a new generation of anti-cancer therapeutics.
authors: Department of Chemistry, University of South Florida, 4202 E. Fowler Ave, Tampa, FL 33620, USA. jianfengcai@usf.edu.
authors: Peng
authors: P
authors: Teng
authors: Xiaolei
authors: X
authors: Zhang
authors: Haifan
authors: H
authors: Wu
authors: Qiao
authors: Q
authors: Qiao
authors: Said M
authors: SM
authors: Sebti
authors: Jianfeng
authors: J
authors: Cai
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D045744:Cell Line, Tumor; D020650:Combinatorial Chemistry Techniques; D004247:DNA / Q000187:drug effects*; D005260:Female; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D019151:Peptide Library; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D057786:Peptidomimetics / Q000138:chemical synthesis* / Q000494:pharmacology*; D050796:STAT3 Transcription Factor / Q000187:drug effects*; D018909:src Homology Domains / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D019151:Peptide Library; D010455:Peptides; D057786:Peptidomimetics; D050796:STAT3 Transcription Factor; D004247:DNA