title: Genetics of cognition in epilepsy.
abstract: With the completion of the Human Genome Project and the advent of more advanced sequencing platforms capable of high throughput genotyping at reduced cost, research on the genetics/genomics of cognition has expanded rapidly over the past several decades. This has been facilitated even further by global consortia including HapMap, 1000 Genomes Project, ENCODE, and others, which have made information regarding genetic variation and genomic functional elements readily available to all researchers. Thus, the goal of this Targeted Review is not to provide an exhaustive review of the existing literature on the role of genetic factors in cognition. Rather, we will highlight some of the most consistent findings in this field, review the research in epilepsy to date, and provide a background within which to set forth unique opportunities epilepsy may provide to further elucidate the role of genetics in cognition.
authors: Epilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA; Department of Psychiatry & Psychology, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA; Department of Neurology, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address: buschr@ccf.org.
authors: Robyn M
authors: RM
authors: Busch
authors: Epilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA; Department of Neurology, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.
authors: Imad
authors: I
authors: Najm
authors: Charles Matthew Neuropsychology Section, Department of Neurology, University of Wisconsin, Madison, WI, USA.
authors: Bruce P
authors: BP
authors: Hermann
authors: Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.
authors: Charis
authors: C
authors: Eng
mesh_terms: D003072:Cognition Disorders / Q000235:genetics*; D004827:Epilepsy / Q000235:genetics*; D006801:Humans
keywords: Cognition; Epilepsy; Epilepsy surgery; Genetics; Genomics; Neuropsychology