title: Evaluation of gastric submucosal tumors using endoscopically visualized features with submucosal endoscopy.
abstract: Although the macroscopic characteristics of submucosal tumors (SMTs), such as gastrointestinal stromal tumors (GISTs), have been characterized, the assessment of SMTs by their endoscopically visualized features (EVF; which are observed by endoscopic imaging under direct view) remains unevaluated. The aim of the present study was to investigate the potential of endoscopic diagnostics for SMTs using EVF. The EVF of 26 gastric SMT cases, in which the final pathological diagnosis was obtained by core biopsy using the submucosal endoscopy with mucosal flap method, were retrospectively reviewed. Each type of SMT was classified according to the following five EVF: Color, clarity, shape, tumor coating and solidity. Additionally, the EVF of 13 low-risk GISTs and 13 benign submucosal tumors (BSTs) were comparatively evaluated for the five abovementioned EVF. Similar trends were identified between the low-risk GISTs, granular cell tumors and the schwannoma with regard to EVF. However, while these tumors exhibited cloudy EVF, the leiomyomas tended to exhibit clear EVF. Among SMTs of the heterotopic pancreas type, the EVF demonstrated particularly small nodules of the pancreatic tissue itself. Although the sample size included in the present study is small, a classification system for gastric SMTs was proposed according to the EVF. When compared with the BST group, the GIST group demonstrated a significantly higher frequency of tumors that exhibited a combination of three EVF (white, cloudy and rigid) that are consistent with all gastric GISTs (P<0.05). Gastric SMTs may be classified based on the EVF, which indicates that the EVF possess potential diagnostic value for the differentiation of GISTs from BSTs.
authors: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Miki, Kagawa 761-0793, Japan.
authors: Hideki
authors: H
authors: Kobara
authors: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Miki, Kagawa 761-0793, Japan.
authors: Hirohito
authors: H
authors: Mori
authors: Department of Pharmacology, Faculty of Medicine, Kagawa University, Miki, Kagawa 761-0793, Japan.
authors: Kazi
authors: K
authors: Rafiq
authors: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Miki, Kagawa 761-0793, Japan.
authors: Tae
authors: T
authors: Matsunaga
authors: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Miki, Kagawa 761-0793, Japan.
authors: Shintaro
authors: S
authors: Fujihara
authors: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Miki, Kagawa 761-0793, Japan.
authors: Noriko
authors: N
authors: Nishiyama
authors: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Miki, Kagawa 761-0793, Japan.
authors: Maki
authors: M
authors: Ayaki
authors: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Miki, Kagawa 761-0793, Japan.
authors: Tatsuo
authors: T
authors: Yachida
authors: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Miki, Kagawa 761-0793, Japan.
authors: Johji
authors: J
authors: Tani
authors: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Miki, Kagawa 761-0793, Japan.
authors: Hisaaki
authors: H
authors: Miyoshi
authors: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Miki, Kagawa 761-0793, Japan.
authors: Kiyohito
authors: K
authors: Kato
authors: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Miki, Kagawa 761-0793, Japan.
authors: Hideki
authors: H
authors: Kamada
authors: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Miki, Kagawa 761-0793, Japan.
authors: Hirohito
authors: H
authors: Yoneyama
authors: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Miki, Kagawa 761-0793, Japan.
authors: Asahiro
authors: A
authors: Morishita
authors: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Miki, Kagawa 761-0793, Japan.
authors: Kunihiko
authors: K
authors: Tsutsui
authors: Life Science Research Center, Faculty of Medicine, Kagawa University, Miki, Kagawa 761-0793, Japan.
authors: Hisakazu
authors: H
authors: Iwama
authors: Department of Diagnostic Pathology, Faculty of Medicine, Kagawa University, Miki, Kagawa 761-0793, Japan.
authors: Reiji
authors: R
authors: Haba
authors: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Miki, Kagawa 761-0793, Japan.
authors: Tsutomu
authors: T
authors: Masaki
keywords: diagnostic techniques; differential diagnosis; endoscopic imaging; gastrointestinal stromal tumors; submucosal endoscopy; submucosal tumor