title: Synthesis of N-aryl substituted, five- and six-membered azacycles using aluminum-amide complexes.
abstract: Synthesis of N-aryl substituted, five- and six-membered azacycloalkanes, isoindolines and tetrahydroisoquinolines, has been described. In this synthesis, cyclic ethers (n = 1, 2) were treated with dimethylaluminum-amide reagents, derived from a range of aryl amines and trimethylaluminum, to afford the corresponding azacycles in good yields.
authors: Department of Life Chemistry, Catholic University of Daegu, Gyeongsan-si, Gyeongbuk 712-702, South Korea. leeshh@cu.ac.kr.
authors: Balaji L
authors: BL
authors: Korbad
authors: Sang-Hyeup
authors: SH
authors: Lee
mesh_terms: D000535:Aluminum / Q000737:chemistry*; D000577:Amides / Q000737:chemistry*; D001372:Aza Compounds / Q000138:chemical synthesis*; D003500:Cyclization; D003516:Cycloparaffins / Q000138:chemical synthesis*; D007211:Indoles / Q000138:chemical synthesis*; D044005:Tetrahydroisoquinolines / Q000138:chemical synthesis*
chemical_list: D000577:Amides; D001372:Aza Compounds; D003516:Cycloparaffins; D007211:Indoles; D044005:Tetrahydroisoquinolines; D000535:Aluminum