title: Pattern recognition of HER-1 in biological fluids using stochastic sensing.
abstract: Stochastic sensing was employed for pattern recognition of HER-1 in biological fluids. Nanostructured materials such as 5,10,15,20-tetraphenyl-21H,23H-porphyrin, maltodextrin and α-cyclodextrin were used to modify diamond paste for stochastic sensing of HER-1. Pattern recognition of HER-1 in biological fluids was performed in a linear concentration range between 5.60 × 10(-11) and 9.72 × 10(-7 )mg ml(-1). The lower limits of determination (10(-12 )mg ml(-1) magnitude order) were recorded when maltodextrin and α-cyclodextrin were used for stochastic sensing. The pattern recognition test of HER-1 in biological fluids samples shows high reliability for both qualitative and quantitative assay.
authors: Laboratory of Electrochemistry and PATLAB, National Institute of Research for Electrochemistry and Condensed Matter , Bucharest-6 , Romania .
authors: Raluca-Ioana
authors: RI
authors: Stefan-van Staden
authors: Iuliana
authors: I
authors: Moldoveanu
authors: Camelia Stanciu
authors: CS
authors: Gavan
mesh_terms: D001202:Ascitic Fluid / Q000737:chemistry*; D014408:Biomarkers, Tumor / Q000097:blood / Q000302:isolation & purification*; D015374:Biosensing Techniques / Q000379:methods*; D066246:ErbB Receptors / Q000097:blood / Q000302:isolation & purification*; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*; D010363:Pattern Recognition, Automated / Q000379:methods*; D011134:Polysaccharides / Q000737:chemistry; D011166:Porphyrins / Q000737:chemistry; D013269:Stochastic Processes; D047391:alpha-Cyclodextrins / Q000737:chemistry
chemical_list: C000599518:5,10,15,20-tetraphenyl-21H,23H-porphine; D014408:Biomarkers, Tumor; D011134:Polysaccharides; D011166:Porphyrins; D047391:alpha-Cyclodextrins; C008315:maltodextrin; C512478:EGFR protein, human; D066246:ErbB Receptors; C032613:alpha-cyclodextrin
keywords: HER-1; screening test; stochastic sensors