title: A 'clicked' tetrameric hydroxamic acid glycopeptidomimetic antagonizes sugar-lectin interactions on the cellular level.
abstract: A tetrameric N-acetyl galactosaminyl (GalNAc) peptidomimetic was constructed by N-acetylation of repeating proline-based hydroxamic acid units, followed by a convergent 'click chemistry' coupling. This novel glycopeptidomimetic was determined to effectively antagonize the interaction between a transmembrane hepatic lectin and GalNAc on the cellular level.
authors: Key Laboratory for Advanced Materials & Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237, PR China.
authors: Hai-Lin
authors: HL
authors: Zhang
authors: National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 189 Guo Shoujing Rd., Shanghai 201203, PR China.
authors: Yi
authors: Y
authors: Zang
authors: PPSM, Institut d'Alembert, ENS de Cachan, CNRS UMR 8531, 61 Avenue du Pt Wilson, F-94235 Cachan, France.
authors: Juan
authors: J
authors: Xie
authors: National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 189 Guo Shoujing Rd., Shanghai 201203, PR China.
authors: Jia
authors: J
authors: Li
authors: Key Laboratory for Advanced Materials & Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237, PR China.
authors: Guo-Rong
authors: GR
authors: Chen
authors: Key Laboratory for Advanced Materials & Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237, PR China.
authors: Xiao-Peng
authors: XP
authors: He
authors: Key Laboratory for Advanced Materials & Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237, PR China.
authors: He
authors: H
authors: Tian
mesh_terms: D016475:3T3 Cells; D000818:Animals; D040761:Biomimetic Materials / Q000008:administration & dosage / Q000138:chemical synthesis; D050260:Carbohydrate Metabolism / Q000187:drug effects / Q000502:physiology*; D057930:Click Chemistry / Q000379:methods; D004305:Dose-Response Relationship, Drug; D006020:Glycopeptides / Q000737:chemistry; D056945:Hep G2 Cells; D006801:Humans; D006877:Hydroxamic Acids / Q000008:administration & dosage* / Q000737:chemistry*; D037102:Lectins / Q000378:metabolism*; D051379:Mice; D010455:Peptides / Q000008:administration & dosage* / Q000737:chemistry*
chemical_list: D006020:Glycopeptides; D006877:Hydroxamic Acids; D037102:Lectins; D010455:Peptides