title: Identifying orphan G protein coupled receptors in drug discovery.
abstract: G-protein coupled receptors (GPCRs) represent the most tractable family of drug targets. Those GPCRs identified by sequence only, but lacking an endogenous ligand, are defined as orphan GPCRs (oGPCRs) and might represent the next generation of targets for GPCR drug discovery. Drug discovery at oGPCRs is a resource intensive approach and frequently taken 'at-risk' without a clear understanding of the role in a disease. Identification of oGPCRs is, therefore, a prerequisite for the initiation of a drug discovery program.:
authors: Neuroscience Discovery Research, Wyeth Research, CN-8000, Princeton, NJ 08543, USA.
authors: John
authors: J
authors: Dunlop
authors: DiscoveRx Corporation, 42501 Albrae St. Fremont, CA 94538, USA. Electronic address:reglen@discoverx.com.
authors: Richard M
authors: RM
authors: Eglen