title: Relationship of osteopontin and renal function with severity of coronary artery lesions.
abstract: OBJECTIVE
  To explore the relationship of plasma osteopontin (OPN) level and renal function with severity of coronary artery lesions.
  
  
  METHODS
  OPN level and renal function were detected and compared in 210 patients with coronary heart disease (CHD group) and 134 patients without coronary heart disease (control group) to analyze the relationship of osteopontin and renal function with severity of coronary artery lesions.
  
  
  RESULTS
  Plasma OPN and creatinine level were significantly higher in CHD group than those in control group (P<0.01), and estimated glomerular filtration rate (eGFR) was lower in CHD group than that in control group (P<0.01). The proportions of multi-vessel lesion and moderate to severe decreased renal function were higher in patients with high osteopontin than those in patients with low osteopontin (P<0.05), and the proportion of multi-vessel lesion was higher in patients with moderate to severe decreased renal function than that in normal renal function (P<0.05). Osteopontin and renal failure were the independent risk factors for coronary heart disease.
  
  
  CONCLUSIONS
  Plasma OPN level is associated with renal failure, both of which are correlated with the severity of coronary artery lesions.
authors: Department of Cardiology, Xinhua (Chongming) Hospital, School of Medicine, Shanghai Jiaotong University Shanghai 202150, China.
authors: Jian
authors: J
authors: Chen
authors: Department of Cardiology, Xinhua (Chongming) Hospital, School of Medicine, Shanghai Jiaotong University Shanghai 202150, China.
authors: Yingmin
authors: Y
authors: Lu
authors: Department of Cardiology, Xinhua (Chongming) Hospital, School of Medicine, Shanghai Jiaotong University Shanghai 202150, China.
authors: Damin
authors: D
authors: Huang
authors: Department of Cardiology, Xinhua (Chongming) Hospital, School of Medicine, Shanghai Jiaotong University Shanghai 202150, China.
authors: Xiaohan
authors: X
authors: Luo
authors: Department of Cardiology, Xinhua (Chongming) Hospital, School of Medicine, Shanghai Jiaotong University Shanghai 202150, China.
authors: Yachen
authors: Y
authors: Zhang
keywords: Osteopontin; atherosclerosis; coronary heart disease; renal failure