title: Exercise physiology in heart failure and preserved ejection fraction.
abstract: Recent advances in the pathophysiology of exercise intolerance in patients with heart failure with preserved ejection fraction (HFPEF) suggest that noncardiac peripheral factors contribute to the reduced peak V(o2) (peak exercise oxygen uptake) and to its improvement after endurance exercise training. A greater understanding of the peripheral skeletal muscle vascular adaptations that occur with physical conditioning may allow for tailored exercise rehabilitation programs. The identification of specific mechanisms that improve whole body and peripheral skeletal muscle oxygen uptake could establish potential therapeutic targets for medical therapies and a means to follow therapeutic response.
authors: Faculty of Rehabilitation Medicine, Alberta Cardiovascular and Stroke Research Centre (ABACUS), Mazankowski Alberta Heart Institute, University of Alberta, 3-16 Corbett Hall, Edmonton, Alberta T6G-2G4, Canada. Electronic address: mark.haykowsky@ualberta.ca.
authors: Mark J
authors: MJ
authors: Haykowsky
authors: Cardiology Section, Department of Internal Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1045, USA.
authors: Dalane W
authors: DW
authors: Kitzman
mesh_terms: D000368:Aged; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test / Q000379:methods*; D017079:Exercise Tolerance / Q000502:physiology; D005260:Female; D006333:Heart Failure / Q000175:diagnosis* / Q000534:rehabilitation; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000098:blood supply / Q000502:physiology*; D010101:Oxygen Consumption / Q000502:physiology; D016032:Randomized Controlled Trials as Topic; D012016:Reference Values; D012680:Sensitivity and Specificity; D013318:Stroke Volume / Q000502:physiology*; D013577:Syndrome; D016277:Ventricular Function, Left / Q000502:physiology*
keywords: Exercise physiology; Heart failure and preserved ejection fraction; Physical conditioning