title: In vitro and in vivo anti-cancer effects of targeting and photothermal sensitive solid lipid nanoparticles.
abstract: This report focuses on the in vitro and in vivo anti-cancer effects evaluation of targeting and photothermal sensitive solid lipid nanoparticles (SLN) for the co-loading of docetaxel (DTX), oxidized single-walled carbon nanotubes (OSWNT) and folic acid (FA). Compared with free DTX, FA-DTX-OSWNT-SLN could efficiently cross cell membranes and afford higher antitumor efficacy on the human hepatic carcinoma cell line (SMMC-7721) in vitro. Annexin V-FITC/PI double staining further confirmed that FA-DTX-OSWNT-SLN induced higher apoptotic rates on SMMC-7721 cells. Meanwhile, the combination of near-infrared (NIR) laser irradiation at 808 nm with FA-DTX-OSWNT-SLN significantly enhanced cell inhibition. For in vivo experiments, the relative tumor volume of the sarcomaia 180 (S180) tumor-bearing mice in FA-DTX-OSWNT-SLN group was significantly smaller than that of control groups. Furthermore, when combining with NIR laser irradiation, the suppression on tumor growth was much stronger. In a word, FA-DTX-OSWNT-SLN in combination with 808 nm NIR laser could exhibit both in vitro and in vivo anti-tumor effects and may be a promising approach for cancer therapy.
authors: School of Pharmaceutical Sciences, Zhengzhou University , Zhengzhou , PR China and.
authors: Xiali
authors: X
authors: Zhu
authors: Shengnan
authors: S
authors: Huang
authors: Heqing
authors: H
authors: Huang
authors: Yingjie
authors: Y
authors: Zhang
authors: Yingxia
authors: Y
authors: Xie
authors: Lin
authors: L
authors: Hou
authors: Huijuan
authors: H
authors: Zhang
authors: Jinjin
authors: J
authors: Shi
authors: Zhenzhong
authors: Z
authors: Zhang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D001692:Biological Transport / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D059248:Chemoradiotherapy; D000077143:Docetaxel; D004337:Drug Carriers / Q000737:chemistry; D005492:Folic Acid / Q000008:administration & dosage; D006801:Humans; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010316:Particle Size; D043823:Taxoids / Q000008:administration & dosage* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D037742:Nanotubes, Carbon; D043823:Taxoids; D000077143:Docetaxel; D005492:Folic Acid
keywords: Anti-tumor effects; nanoparticles; near-infrared laser; single-walled carbon nanotubes