title: Secondary pulmonary conventional chordoma arising from primary sarcomatoid chordoma of the sacrum: A case report.
abstract: Chordomas are low- to intermediate-grade malignant tumors that recapitulate the notochord. Chordomas belong to the dysontogenetic bone tumors and appear primarily in the region of the axial skeleton. Chordomas are divided into conventional, chondroid, sarcomatoid and dedifferentiated subtypes. The different subtypes of chordoma have varied survival periods. According to the literature to date, secondary pulmonary and lymph-node metastases occur most frequently, followed by liver, bone and skin metastases. To the best of our knowledge, there has been no previous report of one subtype of chordoma metastasizing or transforming into another subtype with a different histopathology. This study presents a 24-year-old man with secondary pulmonary conventional chordoma arising from a primary sarcomatoid chordoma of the sacrum. The patient was alive at the end of November, 2009 and the survival time exceeded eight years. This is the first case of a patient with primary sarcomatoid chordoma of the sacrum with complete remission in whom a secondary pulmonary conventional chordoma arose from the primary cancer.
authors: Department of Medicine, Division of Hematology/Oncology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan, R.O.C.
authors: Jia-Hong
authors: JH
authors: Chen
authors: Hualien Armed Forces General Hospital, Hualien 920, Taiwan, R.O.C.
authors: Kuan-Yu
authors: KY
authors: Chen
authors: Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan, R.O.C.
authors: Dueng-Yuan
authors: DY
authors: Hueng
authors: Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan, R.O.C.
authors: Jong-Shiaw
authors: JS
authors: Jin
keywords: chordoma; conventional; sarcomatoid; transformation