title: Low total IgM values and high cytomegalovirus loads in the blood of newborns with symptomatic congenital cytomegalovirus infection.
abstract: OBJECTIVE
  Neurological outcomes differ considerably between symptomatic and asymptomatic infants with congenital cytomegalovirus (CMV) infection. Our objective was to characterize laboratory markers in symptomatic newborns in comparison with asymptomatic newborns with congenital CMV infection.
  
  
  METHODS
  Ten newborns with symptomatic and 13 newborns with asymptomatic congenital CMV infection were included in this 3-year prospective cohort study. Total immunoglobulin M (IgM), CMV-IgM, CMV antigenemia, and CMV-DNA in blood and urine were measured and their positive rates and quantitative values compared between the symptomatic and asymptomatic groups.
  
  
  RESULTS
  Fifty percent of newborns in the symptomatic group were positive based on total IgM; this was significantly lower than in the asymptomatic group (100%). Quantitative total IgM values were significantly lower, and there were significantly more copies of CMV-DNA in the blood of symptomatic newborns than in asymptomatic newborns (median values for total IgM: 14 vs. 43 mg/dL and blood CMV-DNA: 3.2×102 vs. 3.5×101 copies/106 white blood cells). CMV-IgM, CMV antigenemia, and urine CMV-DNA did not differ significantly between groups.
  
  
  CONCLUSIONS
  Low total IgM values and high blood CMV loads were associated with the presence of symptoms in newborns with congenital CMV infection.
authors: Yoko
authors: Y
authors: Kobayashi
authors: Ichiro
authors: I
authors: Morioka
authors: Tsubasa
authors: T
authors: Koda
authors: Yuji
authors: Y
authors: Nakamachi
authors: Yoko
authors: Y
authors: Okazaki
authors: Yoriko
authors: Y
authors: Noguchi
authors: Miki
authors: M
authors: Ogi
authors: Masatsugu
authors: M
authors: Chikahira
authors: Kenji
authors: K
authors: Tanimura
authors: Yasuhiko
authors: Y
authors: Ebina
authors: Toru
authors: T
authors: Funakoshi
authors: Masanobu
authors: M
authors: Ohashi
authors: Kazumoto
authors: K
authors: Iijima
authors: Naoki
authors: N
authors: Inoue
authors: Seiji
authors: S
authors: Kawano
authors: Hideto
authors: H
authors: Yamada
mesh_terms: D003586:Cytomegalovirus Infections / Q000097:blood / Q000151:congenital* / Q000276:immunology; D004279:DNA, Viral / Q000097:blood* / Q000652:urine; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D007231:Infant, Newborn; D011446:Prospective Studies
chemical_list: D004279:DNA, Viral; D007075:Immunoglobulin M