title: In silico finding of Putative Cis-Acting Elements for the Tethering of Polycomb Repressive Complex2 in Human Genome.
abstract: Polycomb Repressive Complex2 maintains a predetermined state of transcription which constitutes a cellular memory stable over many cell divisions. Since this complex acts through the regulation of chromatin structure, it is important to understand how it is recruited to chromatin. The specific target sequences of this complex such as PRE (polycomb repressive element) have not been completely recognized in human genome. In this study, we have compared the target sequences of this complex with non-target genes in tumor cell lines. Through in silico and statistical analyses, we have identified some motifs which are over-represented in target genes against non-target genes. Analyzing these motifs shows some transcription factors which are potential recruiters of Polycomb repressive complex2.
authors: Department of Genetics, Shahid Chamran University of Ahvaz, Ahvaz, Iran ; Department of Genetics, School of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
authors: Mohammadreza
authors: M
authors: Hajjari
authors: Department of Genetics, School of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
authors: Mehrdad
authors: M
authors: Behmanesh
authors: Department of Genetics, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
authors: Mohammad Mehdi
authors: MM
authors: Jahani
keywords: Epigenetics; PRC2; SUZ12; Transcription factors; in silico Analysis