title: The unique pathology of nonpolypoid colorectal neoplasia in IBD.
abstract: Patients with inflammatory bowel disease may develop dysplasia in the cryptal epithelium, polypoid neoplasias, and nonpolypoid (flat) adenomas, lesions at risk to proceed to colorectal carcinoma. The onset of invasion in nonpolypoid adenomas may occur without changes in the shape or the size of the lesion. In experimental animals, some colonotropic carcinogens induce polypoid and nonpolypoid neoplasias and others induce polypoid neoplasias exclusively. Some of the biologic attributes of nonpolypoid adenomas in humans can be demonstrated in laboratory animals.
authors: Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, Stockholm 17176, Sweden. Electronic address: Carlos.Rubio@ki.se.
authors: Carlos A
authors: CA
authors: Rubio
authors: Department of Gastrointestinal Endoscopy, Karolinska University Hospital, Stockholm 17176, Sweden.
authors: Premysl
authors: P
authors: Slezak
mesh_terms: D000236:Adenoma / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D017209:Apoptosis; D002277:Carcinoma / Q000209:etiology / Q000473:pathology*; D049109:Cell Proliferation; D003111:Colonic Polyps / Q000209:etiology / Q000473:pathology*; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications / Q000473:pathology*; D009077:Mucins / Q000378:metabolism; D011230:Precancerous Conditions / Q000209:etiology / Q000473:pathology*; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D016283:Proto-Oncogene Proteins p21(ras); D051381:Rats; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D018631:ras Proteins / Q000378:metabolism
chemical_list: C117307:KRAS protein, human; D009077:Mucins; D011518:Proto-Oncogene Proteins; D016159:Tumor Suppressor Protein p53; D016283:Proto-Oncogene Proteins p21(ras); D018631:ras Proteins
keywords: Biologic attributes; Chronologic appearance; Classification; Experimental studies; Histopathology; IBD; Nonpolypoid colorectal adenomas