title: Clinico-histopathologic types of maxillofacial malignancies with emphasis on sarcomas: a 10-year review.
abstract: BACKGROUND
  Sarcomas are malignant neoplasms that occur anywhere in the human body. Though their occurrence in the head and neck region is rare vis-a-vis other malignancies, their presence is of tremendous concern due to their often grave prognosis.
  
  
  OBJECTIVE
  To determine the pattern of occurrence, histopathologic types of maxillofacial sarcomas and their proportion to other malignant neoplasms of this region based on archival material accumulated over 10 years (2000-2009).
  
  
  METHODS
  A combined retrospective and prospective cross-sectional study.
  
  
  METHODS
  The University of Nairobi Dental Hospital (UNDH).
  
  
  METHODS
  All cases with a diagnosis of sarcoma registered between 2000-2009 were evaluated.
  
  
  RESULTS
  Of the 528 malignancies recorded over the ten-year period, 427 (80.9%) were of epithelial origin while 101 (19.1%) were sarcomas. Patients with epithelial malignancies were older (54.16 +/- 15.94 years) than patients with sarcomas (31.73 +/- 16.78) with the differences having been statistically significant. Osteosarcoma was the most commonly occurring sarcoma (29.7%), followed by Kaposi's sarcoma (KS) (28.7%), fibrosarcoma (FBS) (18.8%), and rhabdomyosarcoma (RMS) (9.9%). Sarcomas peaked in the third decade with 70% occurring below the age of 40 years. The maxilla and the mandible were the most afflicted sites in the maxillofacial region accounting for 52%. The patients on average presented to medical personel about nine months after noticing the lesion with the most frequent complaint having been swelling.
  
  
  CONCLUSIONS
  The present study confirms the relative rarity of maxillofacial sarcomas. It also provides data on the histopathologic types and demographic characteristics of maxillofacial sarcomas in a select Kenyan population. This information is a contribution to the comprehensive documentation of sarcomas that occur globally and is useful in the provision of baseline data upon which future prospective analytical protocols may arise.
authors: M W
authors: MW
authors: Kamau
authors: M L
authors: ML
authors: Chindia
authors: E A O
authors: EA
authors: Dimba
authors: D
authors: D
authors: Awange
authors: L
authors: L
authors: Gathece
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007630:Kenya / Q000453:epidemiology; D008297:Male; D008339:Mandibular Neoplasms / Q000453:epidemiology*; D008441:Maxillary Neoplasms / Q000453:epidemiology*; D008875:Middle Aged; D010157:Palatal Neoplasms / Q000453:epidemiology*; D012509:Sarcoma / Q000453:epidemiology* / Q000473:pathology*; D012737:Sex Factors; D014062:Tongue Neoplasms / Q000453:epidemiology*; D055815:Young Adult