title: Hydrolyzed polyacrylamide grafted maize starch based microbeads: application in pH responsive drug delivery.
abstract: The present study details the synthesis, characterization and pharmaceutical application of hydrolysed polyacrylamide grafted maize starch (HPam-g-MS) as promising polymeric material for the development of pH responsive microbeads. Different grades of graft copolymer were synthesized by changing the net microwave irradiation time, while keeping all other factors constant. Acute oral toxicity study performed in rodents ensured the bio-safety of graft copolymer for clinical application. Various batches of aceclofenac loaded microbeads were prepared by ionic gelation method using synthesized graft copolymers and evaluated for formulation parameters. FTIR spectroscopy confirmed the chemical compatibility between drug and graft copolymer. Results of in vitro release study (USP type-II) carried out in two different pH media (pH 1.2 acid buffer and pH 7.4 phosphate buffer) showed that release rate of drug from developed microbeads was a function of both: (a) surrounding pH and (b) the matrix composition. The drug release was relatively higher at alkaline pH as compared to acidic pH and this feature is desirable from viewpoint of site specific drug delivery. A direct correlation was observed between percentage grafting and microbeads performance and it presents a scope for further research on application and optimization of HPam-g-MS based microbeads as drug delivery carriers.
authors: Department of Pharmaceutics, The Oxford College of Pharmacy, 6/9, 1st cross Begur Road, Hongasandra, Bangalore 560068, India.
authors: C Mallikarjuna
authors: CM
authors: Setty
authors: Department of Pharmaceutics, Shree Dhanvantary Pharmacy College, Kim, Kudsad Road, Surat, Gujarat 394110, India. Electronic address: anand4ds@rediffmail.com.
authors: Anand S
authors: AS
authors: Deshmukh
authors: BDR Pharmaceuticals International Private Limited, Vadodara, Gujarat 390 001, India.
authors: Aravind M
authors: AM
authors: Badiger
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D006863:Hydrogen-Ion Concentration; D008863:Microspheres; D008872:Microwaves; D010316:Particle Size; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013213:Starch / Q000138:chemical synthesis / Q000737:chemistry*; D003313:Zea mays / Q000737:chemistry*; D000099166:Polyacrylamides
chemical_list: D000180:Acrylic Resins; D004337:Drug Carriers; D011108:Polymers; D013213:Starch; D000099166:Polyacrylamides
keywords: Microwave assisted grafting; Starch graft copolymer; pH responsive microbeads