title: Marine actinobacteria: an important source of bioactive natural products.
abstract: Marine environment is largely an untapped source for deriving actinobacteria, having potential to produce novel, bioactive natural products. Actinobacteria are the prolific producers of pharmaceutically active secondary metabolites, accounting for about 70% of the naturally derived compounds that are currently in clinical use. Among the various actinobacterial genera, Actinomadura, Actinoplanes, Amycolatopsis, Marinispora, Micromonospora, Nocardiopsis, Saccharopolyspora, Salinispora, Streptomyces and Verrucosispora are the major potential producers of commercially important bioactive natural products. In this respect, Streptomyces ranks first with a large number of bioactive natural products. Marine actinobacteria are unique enhancing quite different biological properties including antimicrobial, anticancer, antiviral, insecticidal and enzyme inhibitory activities. They have attracted global in the last ten years for their ability to produce pharmaceutically active compounds. In this review, we have focused attention on the bioactive natural products isolated from marine actinobacteria, possessing unique chemical structures that may form the basis for synthesis of novel drugs that could be used to combat resistant pathogenic microorganisms.
authors: Specialized Graduate School Science & Technology Convergence, Department of Marine-Bio. Convergence Science and Marine Bioprocess Research Center, Pukyong National University, Busan 608-739, Republic of Korea.
authors: Panchanathan
authors: P
authors: Manivasagan
authors: Specialized Graduate School Science & Technology Convergence, Department of Marine-Bio. Convergence Science and Marine Bioprocess Research Center, Pukyong National University, Busan 608-739, Republic of Korea.
authors: Kyong-Hwa
authors: KH
authors: Kang
authors: Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai 608 502, Tamil Nadu, India.
authors: Kannan
authors: K
authors: Sivakumar
authors: The University of British Columbia, Faculty of Land and Food Systems, Food Nutrition and Health Program, 2205 East Mall, Vancouver, British Columbia, Canada V6T 1Z4.
authors: Eunice C Y
authors: EC
authors: Li-Chan
authors: Specialized Graduate School Science & Technology Convergence, Department of Marine-Bio. Convergence Science and Marine Bioprocess Research Center, Pukyong National University, Busan 608-739, Republic of Korea.
authors: Hyun-Myung
authors: HM
authors: Oh
authors: Specialized Graduate School Science & Technology Convergence, Department of Marine-Bio. Convergence Science and Marine Bioprocess Research Center, Pukyong National University, Busan 608-739, Republic of Korea. Electronic address: sknkim@pknu.ac.kr.
authors: Se-Kwon
authors: SK
authors: Kim
mesh_terms: D039903:Actinobacteria / Q000378:metabolism*; D000818:Animals; D001688:Biological Products / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans
chemical_list: D001688:Biological Products
keywords: Antibiotics; Bioactive compounds; Chemical structures; Marine actinobacteria; Natural products