title: Parasites alter the pathological phenotype of lupus nephritis.
abstract: Lupus nephritis is one of the most serious complications of systemic lupus erythematosus and manifests with considerable phenotypic and histological heterogeneity. In particular, diffuse proliferative lupus nephritis (DPLN) and membranous lupus nephritis (MLN) represent morphologic forms that are polar opposites. DPLN is associated with autoimmune responses dominated by Th1 immune response associated with high levels of interferon (IFN)-γ. In contrast, a Th2 cytokine response is associated with the pathogenesis of MLN. MRL/lpr mice develop human LN-like immune complex-associated nephritis and provide a suitable histological model for human DPLN. Infection with Schistosoma mansoni skewed a Th2-type immune response induction and IL-10 in MRL/lpr mice, drastically changing the pathophysiology of glomerulonephritis from DPLN to MLN accompanied by increased IgG1 and IgE in the sera. T cells in 32-week-old MRL/lpr mice infected with S. mansoni expressed significantly more IL-4 and IL-10 than T cells of uninfected mice; T cells with IFN-γ were comparable between infected and uninfected MR/lpr mice. Thus, the helminthic infection modified the cytokine microenvironment and altered the pathological phenotype of autoimmune nephritis.
authors: Division of Nephrology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Fukuoka University , Fukuoka , Japan .
authors: Katsuhisa
authors: K
authors: Miyake
authors: Keishi
authors: K
authors: Adachi
authors: Maho
authors: M
authors: Watanabe
authors: Yoshie
authors: Y
authors: Sasatomi
authors: Satoru
authors: S
authors: Ogahara
authors: Yasuhiro
authors: Y
authors: Abe
authors: Kenji
authors: K
authors: Ito
authors: Yombo K
authors: YK
authors: Dan Justin
authors: Takao
authors: T
authors: Saito
authors: Hitoshi
authors: H
authors: Nakashima
authors: Shinjiro
authors: S
authors: Hamano
mesh_terms: D000818:Animals; D016207:Cytokines / Q000235:genetics / Q000276:immunology; D005260:Female; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008181:Lupus Nephritis / Q000097:blood / Q000276:immunology / Q000469:parasitology*; D051379:Mice; D019463:Mice, Inbred MRL lpr; D010641:Phenotype; D012313:RNA / Q000737:chemistry / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012550:Schistosoma mansoni / Q000276:immunology*; D012555:Schistosomiasis mansoni / Q000097:blood / Q000150:complications* / Q000276:immunology / Q000469:parasitology; D013047:Specific Pathogen-Free Organisms; D018417:Th1 Cells / Q000276:immunology / Q000469:parasitology; D018418:Th2 Cells / Q000276:immunology / Q000469:parasitology
chemical_list: D016207:Cytokines; D007074:Immunoglobulin G; D007073:Immunoglobulin E; D012313:RNA
keywords: Diffuse proliferative lupus nephritis; MRL/lpr mice; Schistosoma manson; Th2 type immune responses; membranous lupus nephritis