title: High-resolution 3D proton MRI of hyperpolarized gas enabled by parahydrogen and Rh/TiO2 heterogeneous catalyst.
abstract: Several supported metal catalysts were synthesized, characterized, and tested in heterogeneous hydrogenation of propene with parahydrogen to maximize nuclear spin hyperpolarization of propane gas using parahydrogen induced polarization (PHIP). The Rh/TiO2 catalyst with a metal particle size of 1.6 nm was found to be the most active and effective in the pairwise hydrogen addition and robust, demonstrating reproducible results with multiple hydrogenation experiments and stability for ≥1.5 years. 3D (1) H magnetic resonance imaging (MRI) of 1 % hyperpolarized flowing gas with microscale spatial resolution (625×625×625 μm(3) ) and large imaging matrix (128×128×32) was demonstrated by using a preclinical 4.7 T scanner and 17.4 s imaging scan time.
authors: Laboratory of Magnetic Resonance Microimaging, International Tomography Center, SB RAS, 3A Institutskaya St., Novosibirsk 630090 (Russia) and Novosibirsk State University, 2 Pirogova St., Novosibirsk 630090 (Russia). kovtunov@tomo.nsc.ru.
authors: Kirill V
authors: KV
authors: Kovtunov
authors: Danila A
authors: DA
authors: Barskiy
authors: Aaron M
authors: AM
authors: Coffey
authors: Milton L
authors: ML
authors: Truong
authors: Oleg G
authors: OG
authors: Salnikov
authors: Alexander K
authors: AK
authors: Khudorozhkov
authors: Elizaveta A
authors: EA
authors: Inozemtseva
authors: Igor P
authors: IP
authors: Prosvirin
authors: Valery I
authors: VI
authors: Bukhtiyarov
authors: Kevin W
authors: KW
authors: Waddell
authors: Eduard Y
authors: EY
authors: Chekmenev
authors: Igor V
authors: IV
authors: Koptyug
mesh_terms: D002384:Catalysis; D005740:Gases; D006859:Hydrogen / Q000737:chemistry*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D011522:Protons; D012238:Rhodium / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry*
chemical_list: D005740:Gases; D011522:Protons; C009495:titanium dioxide; D006859:Hydrogen; D014025:Titanium; D012238:Rhodium
keywords: heterogeneous catalysis; hyperpolarized gas; magnetic resonance imaging; parahydrogen; supported catalysts