title: Impact of histopathological variant on the outcome of patients treated by radical cystectomy.
abstract: OBJECTIVE
  It is well established that muscle-invasive urothelial carcinoma (UC) has a marked propensity for divergent differentiation, a fact that has significant diagnostic, prognostic, and therapeutic implications. This work is designed to assess the impact of different histopathologic variants of bladder cancer on morbidity and mortality in patients undergoing radical cystectomy (RC) as compared to the impact in patients with conventional UC.
  
  
  METHODS
  We reviewed records of 201 patients treated with RC and pelvic lymph node dissections. Demographics as well as clinico-pathologic parameters, including histopathological variant, tumor stage, and nodal status, were reviewed. Multivariate analyses were used to evaluate these parameters for overall survival (OS). Kaplan-Meier curves for overall and cancer-specific survival were plotted.
  
  
  RESULTS
  The majority of patients were male (84%), and the mean age was 61±13.1 years (range, 27-87 years). The mean follow-up was 67 months (range, 6-132 months). A histological variant of UC tumor was found in 19 patients (11%). The OS was 55%, and the cancer-specific survival was 35%. The histopathologic variance showed significant impact on morbidity and mortality (p=0.02 and p=0.05, respectively). Patients with divergent histopathology of bladder tumor have poorer survival than do those with UC in a multivariate analysis.
  
  
  CONCLUSIONS
  The pathologic stages at RC and lymph node involvement are predictors for OS. Because of its aggressive nature, histopathologic variance is an independent risk factor determining the outcome in terms of both morbidity and mortality.
authors: Department of Surgery, Aga Khan University, Karachi, Pakistan.
authors: Mehwash
authors: M
authors: Nadeem
authors: Department of Surgery, Aga Khan University, Karachi, Pakistan.
authors: M Hammad
authors: MH
authors: Ather
keywords: Epithelial neoplasms; Malignant; Urinary bladder neoplasms