title: Intestinal and blood-brain drug transport: beyond involvement of a single transport function.
abstract: It is considered that an increased understanding of drug transport in the intestine, liver, kidney and blood-brain barrier is vital to the successful development of new and effective drugs. Hence, there is a need for models that generate even more accurate prediction values than those currently applied. Future improvements in the accuracy of the discovery based predictions will probably need a more in vivo focus rather than a strictly reductionist focus on single cell models or enzymes/transporters. It is also generally believed that these transporters affect the local concentration time profiles of drugs and their metabolites in various tissues, such as liver, brain and kidney.:
authors: Department of Pharmacy, Uppsala University, Box 580, S-751 23 Uppsala, Sweden. Electronic address:hans.lennernas@farmaci.uu.se.
authors: Hans
authors: H
authors: Lennernäs
authors: Department of Pharmacy, Uppsala University, Box 580, S-751 23 Uppsala, Sweden.
authors: Ebba
authors: E
authors: Lundgren