title: Changes in circulating leptin levels during acute stress and associations with craving in abstinent smokers: a preliminary investigation.
abstract: Recent research suggests a role for the appetite hormone leptin in cigarette smoking. This study examined patterns of change in leptin in response to stress and associations with craving during the initial phase of a quit attempt. Thirty-six smokers (average age±SEM, 33.4±2.4) interested in smoking cessation set a quit day and were required to be abstinent for 24h. After, they completed a laboratory session including public speaking and cognitive challenges, and attended 4 weekly post-cessation assessments. Blood samples and self-report measures were collected throughout the laboratory session. The results indicated that leptin levels significantly increased following exposure to acute stress. We also found positive correlations between leptin and craving for cigarettes. No differences were observed in leptin levels between smokers who maintained abstinence for 4 weeks and those who relapsed during this period. These findings suggest that leptin levels may change in response to stress and that leptin could be a useful marker of craving for smoking.
authors: University of Minnesota School of Medicine, 1035 University Drive, Duluth, MN 55812-2487, USA.
authors: Sheena
authors: S
authors: Potretzke
authors: University of Minnesota School of Medicine, 1035 University Drive, Duluth, MN 55812-2487, USA.
authors: Motohiro
authors: M
authors: Nakajima
authors: University of Minnesota School of Medicine, 1035 University Drive, Duluth, MN 55812-2487, USA.
authors: Tiffany
authors: T
authors: Cragin
authors: University of Minnesota School of Medicine, 1035 University Drive, Duluth, MN 55812-2487, USA. Electronic address: malabsi@umn.edu.
authors: Mustafa
authors: M
authors: al'Absi
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D066249:Craving / Q000502:physiology*; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D016540:Smoking Cessation / Q000523:psychology*; D013315:Stress, Psychological / Q000097:blood*; D013375:Substance Withdrawal Syndrome / Q000097:blood* / Q000523:psychology; D014029:Tobacco Use Disorder / Q000097:blood* / Q000523:psychology; D055815:Young Adult
chemical_list: D020738:Leptin
keywords: Craving; Leptin; Relapse; Stress; Tobacco