title: Relation between serum ferritin and liver and heart MRI T2* in beta thalassaemia major patients.
abstract: There is a need for higly accurate non-invasive methods for assessing organ iron content in thalassaemia patients. This study evaluated the relation between serum ferritin level, liver enzyme levels and hepatitis C antibody and liver and heart iron deposition assessed by MRI T2*. Data were obtained from the medical records of 156 thalassemia major patients in Tehran. There was a moderate negative correlation between serum ferritin and liver MRI T2* relaxation time (r = -0.535) and a weak negative correlation between serum ferritin and heart MRI T2* relaxation time (r = -0.361). Hepatitis C infection and liver enzyme levels did not confound or modify the relation between ferritin and liver or heart MRI T2*. Liver and heart MRI T2* readings were poorly correlated (r = 0.281). Routine evaluation of liver and heart iron content using MRI T2* is suggested to better evaluate the haemosiderosis status in thalassemia patients.
authors: A
authors: A
authors: Azarkeivan
authors: M
authors: M
authors: Hashemieh
authors: S
authors: S
authors: Akhlaghpoor
authors: A
authors: A
authors: Shirkavand
authors: M
authors: M
authors: Yaseri
authors: K
authors: K
authors: Sheibani
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D005260:Female; D005293:Ferritins / Q000097:blood*; D006321:Heart / Q000503:physiopathology*; D018937:Hepatitis C Antibodies / Q000097:blood; D006801:Humans; D007492:Iran; D007501:Iron / Q000032:analysis*; D019190:Iron Overload / Q000175:diagnosis; D008099:Liver / Q000201:enzymology / Q000503:physiopathology*; D008111:Liver Function Tests; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008485:Medical Audit; D009206:Myocardium / Q000378:metabolism; D055815:Young Adult; D017086:beta-Thalassemia / Q000208:ethnology / Q000276:immunology / Q000378:metabolism*
chemical_list: D018937:Hepatitis C Antibodies; D005293:Ferritins; D007501:Iron; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase