title: Association between thrombophilia gene polymorphisms and preeclampsia: a meta-analysis.
abstract: OBJECTIVE
  To estimate the relationship between the risk of preeclampsia and two thrombophilia gene single-nucleotide polymorphisms (SNPs), the factor V G1691A SNP and the prothrombin G20210A SNP.
  
  
  METHODS
  A systematic search of the English-language literature up to November 2012 was performed using Medline and EMBASE. Search terms included "preeclampsia," "thrombophilia," "factor V Leiden," "prothrombin gene 20210," and their combinations.
  
  
  RESULTS
  Thirty-seven studies with 5048 preeclampsia patients and 6796 controls were included in the meta-analysis. We found that the prothrombin G20210A polymorphism was associated with an increased risk of all preeclampsia (pooled odds ratio (OR) = 1.81, 95% confidence interval (CI) 1.25-2.63) and severe preeclampsia (pooled OR = 3.02, 95%CI 2.06-4.45). Meanwhile, the pooled OR for the association between factor V Leiden and all preeclampsia was 1.60 (95%CI 1.28-2.00) and 2.45 (95%CI 1.63-3.69) for the cases of severe preeclampsia.
  
  
  CONCLUSIONS
  This meta-analysis supports that the factor V G1691A SNP and the prothrombin G20210A SNP are associated with an increased risk for both preeclampsia overall and severe preeclampsia.
authors: Graduate School of Peking Union Medical College, Beijing, China; National Research Institute for Family Planning, Beijing, China.
authors: Xi
authors: X
authors: Wang
authors: Graduate School of Peking Union Medical College, Beijing, China; National Research Institute for Family Planning, Beijing, China.
authors: Tingting
authors: T
authors: Bai
authors: Graduate School of Peking Union Medical College, Beijing, China; National Research Institute for Family Planning, Beijing, China.
authors: Shengnan
authors: S
authors: Liu
authors: National Research Institute for Family Planning, Beijing, China.
authors: Hong
authors: H
authors: Pan
authors: Graduate School of Peking Union Medical College, Beijing, China; National Research Institute for Family Planning, Beijing, China.
authors: Binbin
authors: B
authors: Wang
mesh_terms: D005165:Factor V / Q000235:genetics*; D005260:Female; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D011516:Prothrombin / Q000235:genetics*; D019851:Thrombophilia / Q000235:genetics*
chemical_list: D005165:Factor V; D011516:Prothrombin