title: Melatonin does not affect oxidative/inflammatory biomarkers in a closed-chest porcine model of acute myocardial infarction.
abstract: OBJECTIVE
  To test whether melatonin reduces oxidative and inflammatory biomarkers in a closed-chest porcine model of acute myocardial infarction.
  
  
  METHODS
  Twenty pigs were randomized to receive a total dosage of 200 mg (0.4 mg/ml) of melatonin, or placebo immediately prior to reperfusion of a coronary artery balloon occlusion in a randomized, observer-blinded, placebo-controlled trial. We assessed high-sensitivity troponin T (hs-TnT), malondialdehyde and interleukin-1b, -6 and -10 at baseline, 30 min and 1, 2, 3 and 4 h after the start of reperfusion.
  
  
  RESULTS
  Seventeen pigs completed the trial. There was an increase in hs-TnT, but no significant difference between the melatonin-treated and placebo-treated groups. There were no significant differences in development of any of the circulating plasma markers between the two groups.
  
  
  CONCLUSIONS
  Melatonin treatment did not result in reduction of inflammatory or oxidative stress markers after experimental myocardial infarction compared to placebo.
authors: Department of Surgery, Herlev Hospital, University of Copenhagen, Herlev, Denmark nathoel@yahoo.dk.
authors: Natalie L
authors: NL
authors: Halladin
authors: Department of Surgery, Herlev Hospital, University of Copenhagen, Herlev, Denmark.
authors: Sarah
authors: S
authors: Ekeløf
authors: Department of Cardiology, Aalborg Hospital - Aarhus University Hospital, Aalborg, Denmark.
authors: Svend Eggert
authors: SE
authors: Jensen
authors: Department of Cardiology, Aalborg Hospital - Aarhus University Hospital, Aalborg, Denmark.
authors: Jens
authors: J
authors: Aarøe
authors: Department of Cardiothoracic Surgery, Aalborg Hospital - Aarhus University Hospital, Aalborg, Denmark.
authors: Benedict
authors: B
authors: Kjærgaard
authors: National Veterinary Institute, Section for Immunology and Vaccinology, Technical University of Denmark, Frederiksberg C, Denmark.
authors: Peter M H
authors: PM
authors: Heegaard
authors: Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C, Denmark.
authors: Jens
authors: J
authors: Lykkesfeldt
authors: Department of Surgery, Herlev Hospital, University of Copenhagen, Herlev, Denmark.
authors: Jacob
authors: J
authors: Rosenberg
authors: Department of Surgery, Herlev Hospital, University of Copenhagen, Herlev, Denmark.
authors: Ismail
authors: I
authors: Gögenur
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D016207:Cytokines / Q000097:blood; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005260:Female; D018836:Inflammation Mediators / Q000097:blood; D008550:Melatonin / Q000008:administration & dosage / Q000494:pharmacology*; D009203:Myocardial Infarction / Q000097:blood*; D018384:Oxidative Stress / Q000187:drug effects*; D013552:Swine; D020107:Troponin T / Q000097:blood
chemical_list: D015415:Biomarkers; D016207:Cytokines; D018836:Inflammation Mediators; D020107:Troponin T; D008550:Melatonin
keywords: Melatonin; acute myocardial infarction; closed-chest porcine model; cytokines; oxidative stress