title: Does family history of depression predict major depression in midlife women? Study of Women's Health Across the Nation Mental Health Study (SWAN MHS).
abstract: This study aims to determine whether family history of depression predicts major depression in midlife women independent of psychosocial and health profiles at midlife. Participants were 303 African American and Caucasian women (42-52 years at baseline) recruited into the Study of Women's Health Across the Nation (SWAN) and the Women's Mental Health Study (MHS) in Pittsburgh. Major depression was assessed annually with the Structured Clinical Interview for DSM-IV. Family mental health history was collected at the ninth or tenth follow-up. Multivariable logistic regression was used to determine whether family history of depression predicted major depression in midlife, adjusting for covariates. The odds of experiencing major depression during the study were three times greater for those with a family history than for those without a family history (OR = 3.22, 95% CI = 1.95-5.31). Family history predicted depression (OR = 2.67, 95% CI = 1.50-4.78) after adjusting for lifetime history of depression, age, trait anxiety, chronic medical conditions, and stressful life events. In analyses stratified by lifetime history of depression, family history significantly predicted depression only among women with a lifetime history of depression. Family history of depression predicts major depression in midlife women generally, but particularly in those with a lifetime history of depression prior to midlife.
authors: Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 3811 O'Hara St., Pittsburgh, PA, 15213, USA.
authors: Alicia
authors: A
authors: Colvin
authors: Gale A
authors: GA
authors: Richardson
authors: Jill M
authors: JM
authors: Cyranowski
authors: Ada
authors: A
authors: Youk
authors: Joyce T
authors: JT
authors: Bromberger
mesh_terms: D000328:Adult; D001741:Black or African American / Q000523:psychology*; D001008:Anxiety Disorders / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D003863:Depression / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics / Q000523:psychology; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics / Q000523:psychology; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D020022:Genetic Predisposition to Disease / Q000523:psychology; D006801:Humans; D016015:Logistic Models; D008593:Menopause / Q000523:psychology; D008603:Mental Health; D008875:Middle Aged; D015143:Philadelphia / Q000453:epidemiology; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors; D044465:White People / Q000523:psychology*; D016387:Women's Health