title: NIH Toolbox Cognition Battery (CB): validation of executive function measures in adults.
abstract: This study describes psychometric properties of the NIH Toolbox Cognition Battery (NIHTB-CB) executive function measures in an adult sample. The NIHTB-CB was designed for use in epidemiologic studies and clinical trials for ages 3 to 85. A total of 268 self-described healthy adults were recruited at four university-based sites, using stratified sampling guidelines to target demographic variability for age (20-85 years), gender, education and ethnicity. The NIHTB-CB contains two computer-based instruments assessing executive function: the Dimensional Change Card Sort (a measure of cognitive flexibility) and a flanker task (a measure of inhibitory control and selective attention). Participants completed the NIHTB-CB, corresponding gold standard convergent and discriminant measures, and sociodemographic questionnaires. A subset of participants (N=89) was retested 7 to 21 days later. Results reveal excellent sensitivity to age-related changes during adulthood, excellent test-retest reliability, and adequate to good convergent and discriminant validity. The NIH Toolbox EF measures can be used effectively in epidemiologic and clinical studies.
authors: 1University of Minnesota,Minneapolis,Minnesota.
authors: Philip David
authors: PD
authors: Zelazo
authors: 1University of Minnesota,Minneapolis,Minnesota.
authors: Jacob E
authors: JE
authors: Anderson
authors: 2Indiana University,Bloomington,Indiana.
authors: Jennifer
authors: J
authors: Richler
authors: 3Westat,Inc.,Rockville,Maryland.
authors: Kathleen
authors: K
authors: Wallner-Allen
authors: 4Northwestern University,Evanston,Illinois.
authors: Jennifer L
authors: JL
authors: Beaumont
authors: 5National Institutes of Health,Bethesda,Maryland.
authors: Kevin P
authors: KP
authors: Conway
authors: 4Northwestern University,Evanston,Illinois.
authors: Richard
authors: R
authors: Gershon
authors: 4Northwestern University,Evanston,Illinois.
authors: Sandra
authors: S
authors: Weintraub
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001288:Attention / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D003936:Diagnosis, Computer-Assisted; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D008875:Middle Aged; D009316:National Institutes of Health (U.S.) / Q000592:standards*; D009483:Neuropsychological Tests; D014481:United States; D054928:Validation Studies as Topic; D055815:Young Adult