title: Total synthesis of the cyanobacterial metabolite nostodione A: discovery of its antiparasitic activity against Toxoplasma gondii.
abstract: A total synthesis of the cyanobacterial natural product nostodione A is reported involving a convergent, diversity-oriented route. A small assemblage of structural analogues were prepared and their cytotoxicity and anti-invasion activity against the protozoal parasite Toxoplasma gondii is reported for the first time.
authors: Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario, Canada L8S 4M1. jmcnult@mcmaster.ca.
authors: J
authors: J
authors: McNulty
authors: K
authors: K
authors: Keskar
authors: C
authors: C
authors: Bordón
authors: R
authors: R
authors: Yolken
authors: L
authors: L
authors: Jones-Brando
mesh_terms: D000977:Antiparasitic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D000458:Cyanobacteria; D005347:Fibroblasts / Q000469:parasitology; D006801:Humans; D026121:Indole Alkaloids / Q000138:chemical synthesis* / Q000494:pharmacology*; D014122:Toxoplasma / Q000187:drug effects* / Q000502:physiology
chemical_list: D000977:Antiparasitic Agents; D026121:Indole Alkaloids; C541082:nostodione A