title: Dual-site sampling improved detection rates for MRSA colonization in patients with cutaneous abscesses.
abstract: Extranasal sites are common reservoirs of Staphylococcus aureus colonization and may be relevant for methicillin-resistant S. aureus (MRSA) screening and infection control strategies. The objective here was to determine whether inguinal specimens could also be screened using Xpert SA Nasal Complete assay for MRSA. Results were compared to broth enrichment culture. Among 162 consented adults seeking care in the emergency department for cutaneous abscesses, inguinal specimens were found positive for MRSA more often than nares specimens, 24% and 26% by PCR or culture, respectively, compared to 19% each by PCR or culture. Overall, 6% of adults colonized with MRSA would have been missed by nares screening alone. Compared to culture, Xpert SA Nasal Complete assay demonstrated sensitivity and specificity of 89% and 97%, respectively, for detecting nares and/or inguinal MRSA colonization. In conclusion, inguinal specimens were a more common reservoir for MRSA than nares specimens in this population of patients.
authors: Department of Emergency Medicine, The George Washington University Medical Faculty Associates, Washington, DC; Department of Epidemiology and Biostatistics, School of Public Health and Health Services, The George Washington University, Washington, DC. Electronic address: larissa@gwu.edu.
authors: L
authors: L
authors: May
authors: Department of Epidemiology and Biostatistics, School of Public Health and Health Services, The George Washington University, Washington, DC.
authors: C
authors: C
authors: McCann
authors: Department of Emergency Medicine, The George Washington University Medical Faculty Associates, Washington, DC; Department of Epidemiology and Biostatistics, School of Public Health and Health Services, The George Washington University, Washington, DC.
authors: G
authors: G
authors: Brooks
authors: Department of Emergency Medicine, Johns Hopkins University, Baltimore, MD.
authors: R
authors: R
authors: Rothman
authors: Infectious Disease Clinical Outcomes Research Unit, Division of Infectious Disease, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA.
authors: L
authors: L
authors: Miller
authors: Department of Epidemiology and Biostatistics, School of Public Health and Health Services, The George Washington University, Washington, DC.
authors: J
authors: J
authors: Jordan
mesh_terms: D000038:Abscess / Q000175:diagnosis* / Q000382:microbiology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001431:Bacteriological Techniques / Q000379:methods*; D002353:Carrier State / Q000175:diagnosis* / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification*; D008875:Middle Aged; D009296:Nasal Cavity / Q000382:microbiology; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D013203:Staphylococcal Infections / Q000175:diagnosis* / Q000382:microbiology; D055815:Young Adult
keywords: Cutaneous abscess; Emergency department; Infection control; Molecular diagnostics