title: Interleukin-28A promotes IFN-γ production by peripheral blood mononuclear cells from patients with Behçet's disease.
abstract: Behçet's disease (BD) is an autoimmune disease of unknown etiology. Interleukin-28A (IL-28A) promotes immune responses and may participate in the pathogenesis of autoimmune diseases. To examine the role of IL-28A in the pathogenesis of BD, we measured the expression of IFN-γ and IL-17 by IL-28A-stimulated peripheral blood mononuclear cells (PBMCs) from 19 patients with BD and 16 healthy individuals. We found that IFN-γ and IL-17 were undetectable in the sera from BD patients and control subjects. The mRNA expression and protein production of IFN-γ by IL-28A-stimulated PBMCs from BD patients were significantly increased compared to healthy individuals. No significant difference was observed in the mRNA expression and protein production of IL-17 by IL-28A-stimulated PBMCs between BD patients and normal individuals.
authors: The State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.
authors: Bing
authors: B
authors: Li
authors: The State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.
authors: Chufang
authors: C
authors: Xie
authors: The State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.
authors: Xiaomin
authors: X
authors: Lin
authors: The State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China. Electronic address: sushaobo7836@gmail.com.
authors: Shao Bo
authors: SB
authors: Su
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000276:immunology*; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis / Q000097:blood* / Q000235:genetics; D020381:Interleukin-17 / Q000096:biosynthesis / Q000097:blood* / Q000235:genetics; D015847:Interleukin-4 / Q000097:blood; D007378:Interleukins / Q000276:immunology* / Q000494:pharmacology; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000096:biosynthesis; D058504:Th17 Cells / Q000276:immunology; D055815:Young Adult; D000095022:Interferon Lambda
chemical_list: D007371:Interferon-gamma; D020381:Interleukin-17; D015847:Interleukin-4; D007378:Interleukins; D012333:RNA, Messenger; C000624353:interferon-lambda, human; D000095022:Interferon Lambda; C508598:IL4 protein, human
keywords: Behçet’s disease; Cytokine; IL-28A; PBMCs