title: Chemotherapy-induced peripheral neurotoxicity (CIPN): what we need and what we know.
abstract: Chemotherapy-induced peripheral neurotoxicity (CIPN) is one of the most frequent and severe long-term side effects of cancer chemotherapy. Preclinical and clinical studies have extensively investigated CIPN searching for effective strategies to limit its severity or to treat CIPN-related impairment, but the results have been disappointing. Among the reasons for this failure are methodological flaws in both preclinical and clinical investigations. Their successful resolution might provide a brighter perspective for future studies. Among the several neurotoxic chemotherapy drugs, oxaliplatin may offer a clear example of a methodological approach eventually leading to successful clinical trials. However, the same considerations apply to the other neurotoxic agents and, although frequently neglected, also to the new "targeted" agents.
authors: Experimental Neurology Unit and Milan Center for Neuroscience, Department of Surgery and Translational Medicine, University of Milano-Bicocca, Monza, Italy.
authors: Guido
authors: G
authors: Cavaletti
mesh_terms: D064420:Drug-Related Side Effects and Adverse Reactions / Q000150:complications*; D006801:Humans; D020258:Neurotoxicity Syndromes / Q000150:complications / Q000191:economics / Q000209:etiology*; D010523:Peripheral Nervous System Diseases / Q000150:complications / Q000191:economics / Q000209:etiology*
keywords: chemotherapy; neuropathy; pathogenesis; toxicity; treatment