title: Neuroprotection of atractylenolide III from Atractylodis macrocephalae against glutamate-induced neuronal apoptosis via inhibiting caspase signaling pathway.
abstract: Glutamate-induced excitotoxicity appears to play a crucial role in neurological disorders. Neuroprotection against glutamate-induced excitotoxicity has been proposed as a therapeutic strategy for preventing and/or treating these excitotoxicity-mediated diseases. In the present study, atractylenolide III, which exhibited significantly neuroprotective effect against glutamate-induced neuronal apoptosis, was isolated from Atractylodes macrocephala by means of bioactivity-guided fractionation. The inhibitory effect of atractylenolide III on glutamate-induced neuronal apoptosis was in a concentration-dependent manner. The anti-apoptotic property of atractylenolide III might be mediated, in part, via inhibiting caspase signaling pathway. Atractylenolide III may have therapeutic potential in excitotoxicity-mediated neurological diseases.
authors: Laboratory of Neuroscience, College of Medicine, Dalian University, Dalian, 116622, People's Republic of China.
authors: Chao
authors: C
authors: Liu
authors: Hong
authors: H
authors: Zhao
authors: Zhi-Hong
authors: ZH
authors: Ji
authors: Xin-Yu
authors: XY
authors: Yu
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D019659:Asteraceae / Q000737:chemistry*; D053148:Caspase 3 / Q000378:metabolism*; D018698:Glutamic Acid / Q000633:toxicity*; D007783:Lactones / Q000494:pharmacology*; D008297:Male; D008807:Mice, Inbred BALB C; D009474:Neurons / Q000166:cytology / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000494:pharmacology*; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D007783:Lactones; D018696:Neuroprotective Agents; D012717:Sesquiterpenes; C424802:atractylenolide III; D018698:Glutamic Acid; D053148:Caspase 3