title: Eleganketal A, a highly oxygenated dibenzospiroketal from the marine-derived fungus Spicaria elegans KLA03.
abstract: Eleganketal A (1), a naturally occurring aromatic polyketide possessing a rare highly oxygenated spiro[isobenzofuran-1,3'-isochroman] ring system, was isolated from the fungus Spicaria elegans KLA03 by culturing it in a modified mannitol-based medium. The structure of 1 including the absolute configuration was determined by combining spectroscopic analysis, synthesis of the racemic permethylated analogue, chiral-phase HPLC separation, and TDDFT-ECD analysis.
authors: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, People's Republic of China.
authors: Yepeng
authors: Y
authors: Luan
authors: Hongjuan
authors: H
authors: Wei
authors: Zhenpei
authors: Z
authors: Zhang
authors: Qian
authors: Q
authors: Che
authors: Yankai
authors: Y
authors: Liu
authors: Tianjiao
authors: T
authors: Zhu
authors: Attila
authors: A
authors: Mándi
authors: Tibor
authors: T
authors: Kurtán
authors: Qianqun
authors: Q
authors: Gu
authors: Dehai
authors: D
authors: Li
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D005658:Fungi / Q000737:chemistry*; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects; D008386:Marine Biology; D015394:Molecular Structure; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012254:Ribavirin / Q000494:pharmacology; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D001572:Benzofurans; D061065:Polyketides; D013141:Spiro Compounds; C000591606:eleganketal A; D012254:Ribavirin