title: Association between RANTES gene polymorphisms and asthma: a meta-analysis.
abstract: BACKGROUND
  A few recent studies have suggested that regulated on activation, normal T cell expressed and secreted (RANTES) polymorphisms (-403 G/A, -28C/G) are associated with asthma. However, there still existed studies which did not confirm these correlations.
  
  
  OBJECTIVE
  The objective of this study was to evaluate the relationship of RANTES and asthma using a meta-analysis.
  
  
  METHODS
  Pubmed, Embase, and Cochrane library databases were systemically searched. Data were extracted by two independent reviewers and pooled odds ratio (OR) with 95% confidence interval (CI) were calculated.
  
  
  RESULTS
  Eighteen studies were enrolled, including a total of 2558 cases and 2630 controls of -403 G/A, as well as 3311 cases and 4031 controls of -28C/G in this meta-analysis. The overall ORs and 95% CIs of -403 G/A were 1.19, 1.06-1.33 (P<0.001) and 1.25, 1.03-1.51 (P = 0.933) in dominant and recessive models, respectively. The overall ORs and 95% CIs of -28G were 1.23, 1.09-1.39 (P = 0.221) and 1.76, 1.32-2.34 (P = 0.356) in dominant and recessive models, respectively. No publication bias among studies was showed.
  
  
  CONCLUSIONS
  This meta-analysis showed that RANTES -403 G/A polymorphism was a risk factor for asthma, while -28C/G polymorphism were not associated with asthma.
authors: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
authors: Dan
authors: D
authors: Wen
authors: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
authors: Xin
authors: X
authors: Du
authors: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
authors: Shao-Ping
authors: SP
authors: Nie
authors: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
authors: Jian-Zeng
authors: JZ
authors: Dong
authors: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
authors: Chang-Sheng
authors: CS
authors: Ma
mesh_terms: D001249:Asthma / Q000235:genetics*; D018946:Chemokine CCL5 / Q000737:chemistry / Q000235:genetics*; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D011110:Polymorphism, Genetic
chemical_list: D018946:Chemokine CCL5