title: High expression of NEDD9 predicts adverse outcomes of colorectal cancer patients.
abstract: NEDD9, a member of Crk-associated substrate (CAS) family, is highly expressed in multiple cancer types and involved cancer cell adhesion, migration, invasion. The prognostic value of NEDD9 has not been evaluated before. The aim of this study was to evaluate the association between NEDD9 expression and survival in colorectal cancer (CRC) patients. NEDD9 expression was analyzed by immunohistochemistry in 92 patients with CRC. Patients were followed-up annually by telephone or at outpatient clinic. The results revealed that high expression of NEDD9 in 68/92 CRC samples, compared with 12/92 normal tissues (P<0.01). Correlation analysis showed high level of expression of NEDD9 was significantly correlated with advanced TNM stage (P=0.014), pT grade (P=0.009), pN (P=0.013) and pM status (P=0.047). Patients with a higher NEDD9 expression had a significantly shorter overall survival (OS) (P<0.01). The multivariate analysis revealed that NEDD9 expression could serve as an independent predictive factor of OS. Our finding demonstrated the potential value of NEDD9 expression level as a prognostic molecular marker and a target for new therapies for CRC patients.
authors: Department of General Surgery, Qingdao Municipal Hospital, Qingdao University Medical College Qingdao, China.
authors: Peng
authors: P
authors: Li
authors: Department of General Surgery, Qingdao Municipal Hospital, Qingdao University Medical College Qingdao, China.
authors: Houmin
authors: H
authors: Zhou
authors: Department of International Clinic, Qingdao Municipal Hospital, Qingdao University Medical College Qingdao, China.
authors: Xinhong
authors: X
authors: Zhu
authors: Department of General Surgery, Qingdao Municipal Hospital, Qingdao University Medical College Qingdao, China.
authors: Guiliang
authors: G
authors: Ma
authors: Department of General Surgery, Qingdao Municipal Hospital, Qingdao University Medical College Qingdao, China.
authors: Chao
authors: C
authors: Liu
authors: Department of General Surgery, Qingdao Municipal Hospital, Qingdao University Medical College Qingdao, China.
authors: Bin
authors: B
authors: Lin
authors: Department of General Surgery, Qingdao Municipal Hospital, Qingdao University Medical College Qingdao, China.
authors: Weizheng
authors: W
authors: Mao
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000032:analysis*; D000230:Adenocarcinoma / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D001706:Biopsy; D016009:Chi-Square Distribution; D015179:Colorectal Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D010750:Phosphoproteins / Q000032:analysis*; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D014408:Biomarkers, Tumor; C099942:NEDD9 protein, human; D010750:Phosphoproteins
keywords: EMT; NEDD9; colorectal cancer; immunohistochemistry; prognosis