title: Fabrication of folic acid sensor based on the Cu doped SnO2 nanoparticles modified glassy carbon electrode.
abstract: A novel folic acid biosensor has been fabricated using Cu doped SnO2 nanoparticles (NPs) synthesized by a simple microwave irradiation method. Powder XRD and TEM studies confirmed that both the pure and Cu doped SnO2 (Cu: 0, 10, 20wt%) crystallized in tetragonal rutile-type structure with spherical morphology. The average crystallite size of pure SnO2 was estimated to be around 16 nm. Upon doping, the crystallite sizes decreased to 9 nm and 5 nm for 10 and 20wt% Cu doped SnO2 respectively. XPS studies confirmed the electronic state of Sn and Cu to be 4+ and 2+ respectively. Cu (20wt%) doped SnO2 NPs are proved to be a good sensing element for the determination of folic acid (FA). Cu-SnO2 NPs (20wt%) modified glassy carbon electrode (GCE) exhibited the lowest detection limit of 0.024 nM over a wide folic acid concentration range of 1.0 × 10(-10) to 6.7 × 10(-5) M at physiological pH of 7.0. The fabricated sensor is highly selective towards the determination of FA even in the presence of a 100 fold excess of common interferent ascorbic acid. The sensor proved to be useful for the estimation of FA content in pharmaceutical sample with satisfactory recovery.
authors: Department of Bioelectronics and Biosensors, Alagappa University, Karaikudi-630 003, Tamilnadu, India.
authors: N
authors: N
authors: Lavanya
authors: S
authors: S
authors: Radhakrishnan
authors: N
authors: N
authors: Sudhan
authors: C
authors: C
authors: Sekar
authors: S G
authors: SG
authors: Leonardi
authors: C
authors: C
authors: Cannilla
authors: G
authors: G
authors: Neri
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D002244:Carbon / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D055664:Electrochemical Techniques; D005492:Folic Acid / Q000032:analysis*; D006801:Humans; D057230:Limit of Detection; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D008839:Microelectrodes; D008872:Microwaves; D017971:Tin Compounds / Q000737:chemistry*
chemical_list: D017971:Tin Compounds; D002244:Carbon; D003300:Copper; D005492:Folic Acid; C045358:stannic oxide