title: Exercise and nutrition in myocardial matrix metabolism, remodeling, regeneration, epigenetics, microcirculation, and muscle.
abstract: Remodeling and myocardial matrix metabolism contributes to cardiac endothelium-myocyte (perivascular fibrosis), myocyte-myocyte (interstitial fibrosis), and mitochondrion-myocyte (fusion and fission) coupling. Matrix metalloproteinases (MMPs), and tissue inhibitor of metalloproteinases (TIMPs) play differential roles in different tissues and diseases. For example, although present in the heart, MMP-3 is known as stromelysin (i.e., stromal tissue enzyme). Interestingly, TIMP-3 causes apoptosis. Exercise and nutrition are synergistic in the mitigation of diseases: exercise releases exosomes containing miRNAs. Nutrition/vitamins B6 and B12 regulate the metabolism of homocysteine (an epigenetic byproduct of DNA/RNA/protein methylation). Thus, epigenetic silencing is an important therapeutic target. The statistical analysis of cohorts may be less indicative for the treatment of a disease, particularly if the 2 twins are different in terms of responding to the medicine for the same disease, therefore, personalized medicine is the future of therapy.
authors: Department of Physiology and Biophysics, University of Louisville School of Medicine, 323 East Chestnut Street, Louisville, KY 40202, USA.
authors: Suresh C
authors: SC
authors: Tyagi
authors: Irving G
authors: IG
authors: Joshua
mesh_terms: D003326:Coronary Circulation; D044127:Epigenesis, Genetic; D015444:Exercise / Q000502:physiology*; D005109:Extracellular Matrix / Q000378:metabolism*; D005355:Fibrosis; D006801:Humans; D008833:Microcirculation; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D009747:Nutritional Physiological Phenomena; D012038:Regeneration
keywords: couplage des myocytes endothéliaux; endothelium–myocyte coupling; epigenetics; matrice; matrix; médecine personnalisée; personalized medicine; épigénétique