title: Pesticide exposure as a risk factor for lymphoproliferative disorders in adults.
abstract: In view of the widespread use of pesticides in Egypt and the increasing incidence of leukaemia and lymphoma we aimed to assess pesticide exposure and other selected variables as risk factors for lymphoproliferative disorders (leukaemia and non-Hodgkin lymphoma). In a hospital-based, retrospective, case-control study in 2011-2012, adult cases of lymphoproliferative disorders (n = 130) were recruited from outpatient clinics in Menoufia, Egypt, while controls (n = 130) were age- and sex-matched fracture patients. Family history of cancer, exposure to X-rays, smoking and use of hair dyes were not risk factors for lymphoproliferative disorders in univariate analysis. History of exposure to pesticides and HCV infection were significant risk factors for lymphoproliferative disorders in multivariate analysis (OR = 2.24; 95% CI: 1.22-4.11 and OR = 2.67; 95% CI: 1.50-4.80 respectively). The risk was significant for cases of non-Hodgkin lymphoma but not chronic lymphocytic leukaemia.
authors: Department of Public Health and Community Medicine, Faculty of Medicine, University of Menoufiya, Menoufiya, Egypt.
authors: E A
authors: EA
authors: Salem
authors: Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, University of Menoufiya, Menoufiya, Egypt.
authors: M M
authors: MM
authors: Hegazy
authors: Department of Clinical Oncology, Faculty of Medicine, University of Menoufiya, Menoufiya, Egypt.
authors: E A
authors: EA
authors: El Khouley
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004534:Egypt / Q000453:epidemiology; D004781:Environmental Exposure / Q000009:adverse effects; D005260:Female; D006801:Humans; D015994:Incidence; D007938:Leukemia / Q000139:chemically induced / Q000453:epidemiology; D008228:Lymphoma, Non-Hodgkin / Q000139:chemically induced / Q000453:epidemiology; D008232:Lymphoproliferative Disorders / Q000139:chemically induced* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects; D010575:Pesticides / Q000633:toxicity*; D012189:Retrospective Studies; D012307:Risk Factors; D011795:Surveys and Questionnaires
chemical_list: D010575:Pesticides