title: Histopathological features and their prognostic impact in nodular lymphocyte-predominant Hodgkin lymphoma--a matched pair analysis from the German Hodgkin Study Group (GHSG).
abstract: Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare lymphoma entity. We performed a matched-pair analysis to evaluate the prognostic impact of several histopathological features in this distinct Hodgkin lymphoma subtype. Lymph node samples of NLPHL patients were tested for CD15, IgD, phosphorylated STAT6, ICOS and Epstein-Barr virus status of the malignant lymphocyte-predominant cells as well as epithelioid cell clusters and activated T cells in the microenvironment. None of these features was associated with a particular clinical outcome. However, patients presenting with epithelioid cell clusters showed a non-significant trend towards a lower relapse rate, justifying further evaluation of this marker.
authors: Dr. Senckenberg Institute of Pathology, Goethe University, Frankfurt am Main, Germany.
authors: Sylvia
authors: S
authors: Hartmann
authors: Dennis A
authors: DA
authors: Eichenauer
authors: Annette
authors: A
authors: Plütschow
authors: Anja
authors: A
authors: Mottok
authors: Roshanak
authors: R
authors: Bob
authors: Karoline
authors: K
authors: Koch
authors: Heinz-Wolfram
authors: HW
authors: Bernd
authors: Sergio
authors: S
authors: Cogliatti
authors: Michael
authors: M
authors: Hummel
authors: Alfred C
authors: AC
authors: Feller
authors: German
authors: G
authors: Ott
authors: Peter
authors: P
authors: Möller
authors: Andreas
authors: A
authors: Rosenwald
authors: Harald
authors: H
authors: Stein
authors: Martin-Leo
authors: ML
authors: Hansmann
authors: Andreas
authors: A
authors: Engert
authors: Wolfram
authors: W
authors: Klapper
mesh_terms: D000293:Adolescent; D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D005647:Fucosyltransferases / Q000032:analysis; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006689:Hodgkin Disease / Q000276:immunology / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D006801:Humans; D007072:Immunoglobulin D / Q000032:analysis; D060889:Inducible T-Cell Co-Stimulator Protein / Q000032:analysis; D016256:Lewis X Antigen / Q000032:analysis; D008213:Lymphocyte Activation / Q000276:immunology; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D009367:Neoplasm Staging; D011379:Prognosis; D012008:Recurrence; D050800:STAT6 Transcription Factor / Q000032:analysis; D016176:T-Lymphocyte Subsets / Q000276:immunology; D059016:Tumor Microenvironment / Q000276:immunology; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C556692:ICOS protein, human; D007072:Immunoglobulin D; D060889:Inducible T-Cell Co-Stimulator Protein; D016256:Lewis X Antigen; D009363:Neoplasm Proteins; D050800:STAT6 Transcription Factor; C494101:STAT6 protein, human; C066693:FUT4 protein, human; D005647:Fucosyltransferases
keywords: histopathological feature; nodular lymphocyte-predominant Hodgkin lymphoma; prognostic impact