title: [Bone metabolism and cardiovascular function update. Cross link of hypertension, bone loss and vascular calcification - common back grounds in renin angiotensin system with anti-aging aspect -].
abstract: Hypertension, osteoporosis and vascular calcification are major diseases in the recent aging society and may share the same backgrounds genetically and environmentally. As treatments to prevent aging-related diseases simultaneously are desirable, we investigate common backgrounds underling these diseases. Renin- angiotensin system, which causes high blood pressure, is found to be involved in bone metabolism. Angiotensin II has been shown to accelerate osteoporosis through RANKL up-regulation in osteoblast. RANKL, in turn, contributes to vascular calcification by regulating bone morphogenetic protein-2 and MGP expression, as well as bone-related proteins. Angiotensin type 1 receptor blockers (ARBs) ameliorate osteoporosis and vascular calcification beyond their blood pressure lowering effects. These pleiotropic effects of antihypertensive drugs such as ARBs might benefit especially hypertensive postmenopausal women.
authors: Department of Nutritional Sciences for Well-being, Kansai University of Welfare Sciences, Japan/Department of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Japan.
authors: Hideo
authors: H
authors: Shimizu
authors: Hironori
authors: H
authors: Nakagami
authors: Ryuichi
authors: R
authors: Morishita
mesh_terms: D000375:Aging / Q000187:drug effects*; D001842:Bone and Bones / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D010024:Osteoporosis / Q000150:complications / Q000378:metabolism*; D012084:Renin-Angiotensin System; D061205:Vascular Calcification / Q000150:complications / Q000378:metabolism*