title: Correlation study of structural parameters of bioadhesive polymers in designing a tunable drug delivery system.
abstract: Keeping in view the importance of network structure in designing tunable drug delivery devices, in the present work, correlation between structural parameters and drug release profile has been determined for polysaccharide gum based polymers. These polymers have been characterized by SEMs, FTIR, (13)C NMR, XRD, TGA/DTA/DTG, DSC, and swelling studies. The mechanical, biocompatible, and mucoadhesive properties of polymers have also been determined. The polymer network parameters such as polymer volume fraction in the swollen state, Flory-Huggins interaction parameter, molecular weight of the polymer chain between two cross-links, cross-link density, and mesh size have been evaluated. Different kinetic models have been applied for the drug release profile of the antifungal drug fluconazole. The swelling and drug release occurred through a non-Fickian diffusion mechanism and a release profile best fitted in the Higuchi square root model. The polymers have been observed as non-thrombogenic, hemo-compatible, and mucoadhesive in nature and may be used in slow drug delivery applications to oral mucosa.
authors: Department of Chemistry, Himachal Pradesh University , Shimla 171005, India.
authors: Baljit
authors: B
authors: Singh
authors: Vikrant
authors: V
authors: Sharma
mesh_terms: D016503:Drug Delivery Systems / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D011108:Polymers / Q000737:chemistry*
chemical_list: D011108:Polymers