title: Towards a genomics approach to tick (Acari: Ixodidae) control in cattle: a review.
abstract: Ticks and tick-borne disease (TBD) are major challenges to cattle production in the tropics and subtropics. Economic losses associated with ticks amount to billions of dollars annually. Although efforts to eradicate ticks and TBD using chemical control strategies have been implemented in many developing countries for decades, these acaricides are costly, and cattle susceptibility to ticks remains unchanged. Traditional breeding methods, where the farmer selected animals using records to improve the host genetic resistance to ticks (HGRT), are less than fully effective and time consuming. The HGRT has been reported in literature. To date, solutions to fight ticks and TBD are still unclear. Development of single-nucleotide polymorphism (SNP) technologies has created an opportunity to estimate breeding values of animals from DNA samples. The use of SNP technology for genomic selection allows information retrieval from the genotype even before the gene is expressed; thus potentially giving farmers the ability to make selection decisions on HGRT at an earlier age. This review discusses factors that affect HGRT, breeding selection, immunology, and genomic approaches and their application to improve HGRT in order to enhance livestock production.
authors: ARC-Animal Production Institute, P. Bag X2, Irene 0062, South Africa; Department of Animal Sciences, Stellenbosch University, P. Bag X1, Matieland 7602, South Africa.
authors: Ntanganedzeni O
authors: NO
authors: Mapholi
authors: Discipline of Animal and Poultry Science, University of KwaZulu-Natal, P. Bag X01, Scottsville 3201, South Africa.
authors: Munyaradzi C
authors: MC
authors: Marufu
authors: ARC-Animal Production Institute, P. Bag X2, Irene 0062, South Africa.
authors: Azwihangwisi
authors: A
authors: Maiwashe
authors: ARC-Animal Production Institute, P. Bag X2, Irene 0062, South Africa.
authors: Cuthbert B
authors: CB
authors: Banga
authors: Department of Livestock and Pasture Sciences, University of Fort Hare, P. Bag X1314, Alice 5700, South Africa.
authors: Voster
authors: V
authors: Muchenje
authors: ARC-Animal Production Institute, P. Bag X2, Irene 0062, South Africa; Delta G, 145 Ice Cave Road, Miles City, MT 59301, USA.
authors: Michael D
authors: MD
authors: MacNeil
authors: Discipline of Animal and Poultry Science, University of KwaZulu-Natal, P. Bag X01, Scottsville 3201, South Africa.
authors: Michael
authors: M
authors: Chimonyo
authors: Department of Animal Sciences, Stellenbosch University, P. Bag X1, Matieland 7602, South Africa. Electronic address: kdzama@sun.ac.za.
authors: Kennedy
authors: K
authors: Dzama
mesh_terms: D000818:Animals; D001947:Breeding; D002417:Cattle; D002418:Cattle Diseases / Q000235:genetics / Q000469:parasitology* / Q000517:prevention & control; D020022:Genetic Predisposition to Disease; D023281:Genomics; D020641:Polymorphism, Single Nucleotide; D013984:Tick Infestations / Q000235:genetics / Q000517:prevention & control / Q000662:veterinary*
keywords: Bos taurus africanus; Genomic selection; Host genetic resistance to ticks; Single-nucleotide polymorphisms; Tick control