title: Chemical constituents from Euphorbia stracheyi and their biological activities.
abstract: Three new diterpenoids, stracheyioids A-C (1-3), as well as 36 known compounds (4-39) were isolated from the whole plants of Euphorbia stracheyi. Compound 1 was a rare 13-deoxy tigliane diterpenoid and compound 2 was an ingenol diterpenoid characterized by an unique 2Z,4Z-decadienoyl acidic moieties. All the known compounds were isolated from E. stracheyi for the first time. Their structures were elucidated on the basis of extensive spectroscopic interpretation. Compounds 1-39 were tested for their cytotoxicity against five cancer cell lines (A-549, MCF-7, Hep G2, Hela and P388) and showed IC50 values in the range 6.64-42.86 μM. The antiangiogenic activities of the isolated compounds were also evaluated using a zebrafish model.
authors: Key Laboratory of Economic Plants and Biotechnology, Germplasm Bank of Wild Species in Southwest China, Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
authors: Da-Song
authors: DS
authors: Yang
authors: Biology Institute of Shandong Academy of Sciences, Jinan 250014, PR China.
authors: Wei-Bing
authors: WB
authors: Peng
authors: Key Laboratory of Economic Plants and Biotechnology, Germplasm Bank of Wild Species in Southwest China, Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
authors: Zi-Lei
authors: ZL
authors: Li
authors: Biology Institute of Shandong Academy of Sciences, Jinan 250014, PR China.
authors: Xue
authors: X
authors: Wang
authors: Key Laboratory of Economic Plants and Biotechnology, Germplasm Bank of Wild Species in Southwest China, Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
authors: Jian-Guo
authors: JG
authors: Wei
authors: Biology Institute of Shandong Academy of Sciences, Jinan 250014, PR China.
authors: Qiu-Xia
authors: QX
authors: He
authors: Key Laboratory of Economic Plants and Biotechnology, Germplasm Bank of Wild Species in Southwest China, Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
authors: Yong-Ping
authors: YP
authors: Yang
authors: Biology Institute of Shandong Academy of Sciences, Jinan 250014, PR China.
authors: Ke-Chun
authors: KC
authors: Liu
authors: Key Laboratory of Economic Plants and Biotechnology, Germplasm Bank of Wild Species in Southwest China, Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China. Electronic address: li_xiaoli11@mail.kib.ac.cn.
authors: Xiao-Li
authors: XL
authors: Li
mesh_terms: D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000302:isolation & purification*; D000818:Animals; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D028481:Euphorbia / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification*; D015027:Zebrafish
chemical_list: D020533:Angiogenesis Inhibitors; D013729:Terpenes
keywords: Cytotoxicity; Diterpenoid; Euphorbia stracheyi; Euphorbiaceae; Sesquiterpene