title: First report of trastuzumab treatment after postoperative Takotsubo cardiomyopathy.
abstract: BACKGROUND
  Trastuzumab is a humanized monoclonal antibody used for the treatment of HER2-positive breast cancer. Cardiotoxicity is a well-known adverse event of trastuzumab use but little has been documented regarding its use in patients with a history of cardiac disease.
  
  
  METHODS
  We describe a case in which trastuzumab treatment was administered to a 40-year-old female patient with early breast cancer after acute heart failure secondary to postoperative Takotsubo cardiomyopathy. After one year of follow-up with close monitoring by echocardiography, there have been no heart-related symptoms. Additional surgery was performed because of positive resection margins at first surgery, without complications, despite the risk of recurrence of Takotsubo cardiomyopathy.
  
  
  CONCLUSIONS
  Trastuzumab can be safely administered after acute heart failure secondary to postoperative Takotsubo cardiomyopathy.
authors: Department of Medical Oncology, Civil Hospital, Strasbourg, France.
authors: Mickael
authors: M
authors: Burgy
authors: Breast Diseases Center, Department of Obstetrics and Gynaecology, Hautepierre Hospital, CHRU, University Hospital Strasbourg, Strasbourg; France.
authors: Hélène
authors: H
authors: Brossat
authors: Department of Medical Oncology, Civil Hospital, Strasbourg, France.
authors: Philippe
authors: P
authors: Barthelemy
authors: Department of Nuclear Medicine, Hautepierre Hospital, CHRU, University Hospital Strasbourg, Strasbourg; France.
authors: Alessio
authors: A
authors: Imperiale
authors: Department of Cardiology, Civil Hospital, Strasbourg, France.
authors: Annie
authors: A
authors: Trinh
authors: Department of Anesthesiology, Hautepierre Hospital, CHRU, University Hospital Strasbourg, Strasbourg; France.
authors: Chafia Assia
authors: CA
authors: Hazam
authors: Department of Medical Oncology, Civil Hospital, Strasbourg, France.
authors: Jean-Pierre
authors: JP
authors: Bergerat
authors: Breast Diseases Center, Department of Obstetrics and Gynaecology, Hautepierre Hospital, CHRU, University Hospital Strasbourg, Strasbourg; France carole.mathelin@chru-strasbourg.fr.
authors: Carole
authors: C
authors: Mathelin
mesh_terms: D000328:Adult; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D005260:Female; D006801:Humans; D054549:Takotsubo Cardiomyopathy / Q000209:etiology / Q000503:physiopathology*; D000068878:Trastuzumab
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D000068878:Trastuzumab
keywords: Early breast cancer; Takotsubo cardiomyopathy; surgery; trastuzumab