title: [Concurrent association of reirradiation therapy with everolimus for lymph node metastasis of gastroesophageal junction cancer: a case report].
abstract: Advanced gastric cancer or gastro-oesophageal junction cancer after a failure of first line chemotherapy have poor outcome. Hereby, we present the first patient treated by radiotherapy with concurrent everolimus, a mTor inhibitor, for a reirradiation of metastasis invading left axillary, infraclavicular and supraclavicular lymph nodes in progression despite several lines of chemotherapy. After 6 months of follow-up, this association provided a satisfactory anti-tumor efficiency and tolerance. Nevertheless, clinical trials are needed in order to confirm this strategy for the treatment of gastric cancer metastasis.
authors: Département de radiothérapie oncologie, Institut Curie, 26, rue d'Ulm, 75248 Paris cedex 05, France.
authors: V
authors: V
authors: Pernin
authors: Département de radiothérapie oncologie, Institut Curie, 26, rue d'Ulm, 75248 Paris cedex 05, France.
authors: P
authors: P
authors: Beuzeboc
authors: Département de radiothérapie oncologie, Institut Curie, 26, rue d'Ulm, 75248 Paris cedex 05, France.
authors: D
authors: D
authors: Peurien
authors: Département de radiothérapie oncologie, Institut Curie, 26, rue d'Ulm, 75248 Paris cedex 05, France.
authors: C
authors: C
authors: Louvet
authors: Département de radiothérapie oncologie, Institut Curie, 26, rue d'Ulm, 75248 Paris cedex 05, France. Electronic address: youlia.kirova@curie.fr.
authors: Y
authors: Y
authors: Kirova
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D059248:Chemoradiotherapy / Q000379:methods*; D004943:Esophagogastric Junction / Q000000981:diagnostic imaging / Q000473:pathology; D000068338:Everolimus; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D019233:Retreatment; D020123:Sirolimus / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D017211:Treatment Failure
chemical_list: D000970:Antineoplastic Agents; D000068338:Everolimus; D020123:Sirolimus
keywords: Adénocarcinome œsogastrique; Association; Concurrent association; Everolimus; Gastro-oesophageal junction cancer; Reirradiation; Réirradiation; Évérolimus