title: Decision making in avoidance-reward conflict: a paradigm for non-human primates and humans.
abstract: Decision making in both animals and humans is influenced by the anticipation of reward and/or punishment. Little is known about how reward and punishment interact in the context of decision making. The Avoidance-Reward Conflict (ARC) Task is a new paradigm that varies the degree of reward and the probability of punishment in a single paradigm that can be used in both non-human primates (NHPs) and humans. This study examined the behavioral pattern in the ARC task in both NHPs and humans. Two adult male NHPs (macaca mulatta) and 20 healthy human volunteers (12 females) participated in the ARC task. NHPs and humans perform similarly on the ARC task. With a high probability of punishment (an aversive air puff to the eye), both NHPs and humans are more likely to forgo reward if it is small or medium magnitude than when it is large. Both NHPs and humans perform similarly on the same behavioral task suggesting the reliability of animal models in predicting human behavior.
authors: Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
authors: Demetrio
authors: D
authors: Sierra-Mercado
authors: Thilo
authors: T
authors: Deckersbach
authors: Amanda R
authors: AR
authors: Arulpragasam
authors: Tina
authors: T
authors: Chou
authors: Alexandra M
authors: AM
authors: Rodman
authors: Amanda
authors: A
authors: Duffy
authors: Eric J
authors: EJ
authors: McDonald
authors: Christine A
authors: CA
authors: Eckhardt
authors: Andrew K
authors: AK
authors: Corse
authors: Navneet
authors: N
authors: Kaur
authors: Emad N
authors: EN
authors: Eskandar
authors: Darin D
authors: DD
authors: Dougherty
mesh_terms: D000328:Adult; D000818:Animals; D001519:Behavior / Q000502:physiology*; D001522:Behavior, Animal / Q000502:physiology*; D003657:Decision Making / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D011323:Primates; D011678:Punishment / Q000523:psychology; D015203:Reproducibility of Results; D012201:Reward