title: Bioactive diterpenoids and flavonoids from the aerial parts of Scoparia dulcis.
abstract: Six new diterpenoids, 4-epi-7α-O-acetylscoparic acid A (1), 7α-hydroxyscopadiol (2), 7α-O-acetyl-8,17β-epoxyscoparic acid A (3), neo-dulcinol (4), dulcinodal-13-one (5), and 4-epi-7α-hydroxydulcinodal-13-one (6), and a new flavonoid, dillenetin 3-O-(6″-O-p-coumaroyl)-β-D-glucopyranoside (10), along with 12 known compounds, were isolated from the aerial parts of Scoparia dulcis. The 7S absolute configuration of the new diterpenoids 1-4 and 6 was deduced by comparing their NOESY spectra with that of a known compound, (7S)-4-epi-7-hydroxyscoparic acid A (7), which was determined by the modified Mosher's method. The flavonoids scutellarein (11), hispidulin (12), apigenin (15), and luteolin (16) and the terpenoids 4-epi-scopadulcic acid B (9) and betulinic acid (19) showed more potent α-glucosidase inhibitory effects (with IC50 values in the range 13.7-132.5 μM) than the positive control, acarbose. In addition, compounds 1, 11, 12, 15, 16, and acerosin (17) exhibited peroxisome proliferator-activated receptor gamma (PPAR-γ) agonistic activity, with EC50 values ranging from 0.9 to 24.9 μM.
authors: The MOE Key Laboratory of Standardization of Chinese Medicines, and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine , Shanghai 201210, People's Republic of China.
authors: Qing
authors: Q
authors: Liu
authors: Qi-Ming
authors: QM
authors: Yang
authors: Hai-Jun
authors: HJ
authors: Hu
authors: Li
authors: L
authors: Yang
authors: Ying-Bo
authors: YB
authors: Yang
authors: Gui-Xin
authors: GX
authors: Chou
authors: Zheng-Tao
authors: ZT
authors: Wang
mesh_terms: D045784:Abietanes / Q000737:chemistry / Q000494:pharmacology; D020909:Acarbose / Q000494:pharmacology; D047310:Apigenin / Q000737:chemistry / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors; D047311:Luteolin / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D047495:PPAR gamma / Q000819:agonists; D035261:Plant Components, Aerial / Q000737:chemistry; D036721:Scoparia
chemical_list: D045784:Abietanes; D004224:Diterpenes; D005419:Flavonoids; D005960:Glucosides; D065089:Glycoside Hydrolase Inhibitors; D047495:PPAR gamma; C000591557:dillenetin 3-O-(6'-O-p-coumaroyl)-beta-D-glucopyranoside; C058658:scopadulcic acid B; C071755:scopadulciol; D047310:Apigenin; D047311:Luteolin; C458179:scutellarein; D020909:Acarbose; C041477:3-hydroxyflavone