title: Effect of light transition metal complexes of methanesulfonic acid hydrazide on the viability of yeast Saccharomyces cerevisiae.
abstract: The effect of methanesulfonic acid hydrazide (MSH) and its complexes [M(MSH)4Cl2] (M = Mn, Fe, Co, Ni) and [Zn(MSH)2Cl2] on culture growth suppression and viability (Colony Forming Units) of Saccharomyces cerevisiae has been studied. The highest culture growth suppression was exhibited by [Co(MSH)4Cl2], whereas the most cytotoxic appeared [Mn(MSH)4Cl2]. The changes in cell morphology were also traced by means of FACS analysis.
authors: Institute of Molecular Biology, Acad. Roumen Tsanev, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, Block 21, 1113 Sofia, Bulgaria. Electronic address: miloshev@bio21.bas.bg.
authors: George A
authors: GA
authors: Miloshev
authors: Institute of Molecular Biology, Acad. Roumen Tsanev, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, Block 21, 1113 Sofia, Bulgaria.
authors: Ekaterina N
authors: EN
authors: Peycheva
authors: Institute of Molecular Biology, Acad. Roumen Tsanev, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, Block 21, 1113 Sofia, Bulgaria.
authors: Nicolay I
authors: NI
authors: Dodoff
authors: Institute of Molecular Biology, Acad. Roumen Tsanev, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, Block 21, 1113 Sofia, Bulgaria.
authors: Daniel N
authors: DN
authors: Kushev
authors: Department of Chemistry, Aristotle University of Thessaloniki, P. O. Box 135, 54124 Thessaloniki, Greece.
authors: Maria
authors: M
authors: Lalia-Kantouri
mesh_terms: D004305:Dose-Response Relationship, Drug; D006834:Hydrazines / Q000737:chemistry* / Q000494:pharmacology; D008698:Mesylates / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development; D013997:Time Factors; D028561:Transition Elements / Q000737:chemistry*
chemical_list: D006834:Hydrazines; D008698:Mesylates; D009942:Organometallic Compounds; D028561:Transition Elements; C045880:methanesulfonic acid
keywords: FACS analysis; Methanesulfonic acid hydrazide; Saccharomyces cerevisiae; Transition metal complexes