title: Comparison of the optical coherence tomographic characters between acute Vogt-Koyanagi-Harada disease and acute central serous chorioretinopathy.
abstract: BACKGROUND
  Acute Vogt-Koyanagi-Harada (VKH) disease and acute central serous chorioretinopathy (CSCR) are two common disorders with serous retinal detachment caused by dysfunction of choroid. The purpose of this study is to compare the morphological changes of these two diseases with spectral domain optical coherence tomography (SD-OCT).
  
  
  METHODS
  In this retrospective comparative study, the SD-OCT images of 65 eyes with acute VKH and 52 eyes with acute CSCR were reviewed for the presence of subretinal fluid, folds of retinal pigment epithelial (RPE), fluctuation of internal limiting membrane (ILM), subretinal septa, retinal pigment epithelium detachment (PED) and bulge of RPE. The foveal thickness was measured using the manual caliper of OCT software. The characteristics of SD-OCT were compared between two diseases.
  
  
  RESULTS
  Subretinal fluid was present in both diseases. Folds of RPE, fluctuation of ILM, subretinal septa were seen only in VKH. Bulge of RPE presented only in CSCR. PED was more common in CSCR than in VKH (44.2% vs 3.1%, p < 0.001). The thickness of fovea and RPE undulation index were significantly greater in VKH compared to that in CSCR (746.7 ± 423.8 vs 444.9 ± 158.8 μm, p < 0.001 and 1.0667 ± 0.0509 vs. 1.0177 ± 0.0023, p = 0.003).
  
  
  CONCLUSIONS
  Our study showed that although VKH and CSCR share similar features on SDOCT, there are characteristic differences between both disease entities.
authors: Dusheng
authors: D
authors: Lin
authors: Weiqi
authors: W
authors: Chen
authors: Guihua
authors: G
authors: Zhang
authors: Huichun
authors: H
authors: Huang
authors: Zhaotao
authors: Z
authors: Zhou
authors: Lingping
authors: L
authors: Cen
authors: Joint Shantou International Eye Center, Shantou University & the Chinese University of Hong Kong, North Dongxia Road, 515041 Shantou, China. drchenhaoyu@gmail.com.
authors: Haoyu
authors: H
authors: Chen
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D056833:Central Serous Chorioretinopathy / Q000175:diagnosis*; D002829:Choroid / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008875:Middle Aged; D055213:Retinal Pigment Epithelium / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*; D014607:Uveomeningoencephalitic Syndrome / Q000175:diagnosis*; D055815:Young Adult