title: The association of leptin with dyslipidemia, arterial hypertension and obesity in Kyrgyz (Central Asian nation) population.
abstract: BACKGROUND
  Leptin, an adipocytokine produced by adipose tissue, along with the traditional cardiometabolic risk factors, contributes to the development of cardiovascular complications. At the same time, ethnic features of adipocytokines have been insufficiently investigated, especially among Asians, who have an increased risk of cardiovascular complications compared with Europeans. Aim of study was to investigate the relationship between leptin levels and age, gender, anthropometric parameters, lipid parameters, arterial hypertension (AH), and obesity in the adult population of ethnic Kyrgyz people living in Central Asia.
  
  
  RESULTS
  In total, 322 ethnic Kyrgyz (145 men, 177 women) aged ≥ 30 years were studied. Waist and hip circumference, body mass index, blood glucose, lipids, leptin, and homeostatic model assessment were measured. Patients in the upper quartile of leptin levels had high values of BMI, WC, systolic and diastolic blood pressure, glucose, and HOMA index compared with patients with lower leptin levels. The prevalence of metabolic syndrome and AH increased with higher levels of leptin. Leptin positively correlated with BMI, WC, triglycerides, and glucose concentrations in patients of both sexes. According to the multivariate logistic regression analysis, elevated leptin levels increased by 30 times the risk of obesity in men, regardless of the presence of type 2 diabetes, and 17.7 times in women.
  
  
  CONCLUSIONS
  Leptin is associated with general and abdominal obesity, dyslipidemia, and insulin resistance in Kyrgyz patients.
authors: Erkin M
authors: EM
authors: Mirrakhimov
authors: Alina S
authors: AS
authors: Kerimkulova
authors: Olga S
authors: OS
authors: Lunegova
authors: Aibek E
authors: AE
authors: Mirrakhimov
authors: Malik P
authors: MP
authors: Nabiev
authors: Kseniya V
authors: KV
authors: Neronova
authors: Asiyat A
authors: AA
authors: Bayramukova
authors: Nazira T
authors: NT
authors: Alibaeva
authors: Nurdin
authors: N
authors: Satarov
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism / Q000503:physiopathology; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D001823:Body Composition; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D050171:Dyslipidemias / Q000097:blood* / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D007707:Kyrgyzstan / Q000453:epidemiology; D020738:Leptin / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; D007328:Insulin; D020738:Leptin; D014280:Triglycerides