title: Polyunsaturated fatty acids and gliomas: a critical review of experimental, clinical, and epidemiologic data.
abstract: Certain polyunsaturated fatty acids (PUFAs) called essential fatty acids (EFAs) cannot be biosynthesized by the body and hence, need to be obtained from diet. These PUFAs and their metabolites have multiple physiological functions that are altered in tumor cells due to a decreased expression of Δdelta-6-desaturase, which is an essential step in their metabolism. As a result, tumor cells would be protected from the toxic effect caused by free radicals, one product of EFA metabolism. EFAs have been proposed to have therapeutic potential in the treatment of glioblastoma. Gliomas are the most common primary tumors of the central nervous system in children and adults. High-grade gliomas remain a therapeutic challenge in neuro-oncology because there is no treatment that achieves a significant improvement in survival. Novel therapeutic strategies that use PUFAs for the treatment of gliomas have been assessed in cell cultures, rodent glioma models, and humans, with encouraging results. Here we review the latest progress made in the field.
authors: Biología Celular, Histología y Embriología, Facultad de Ciencias Médicas, INICSA (CONICET-Universidad Nacional de Córdoba), Córdoba, Argentina; Servicio de Patología, Hospital Rawson de Córdoba, Córdoba, Argentina.
authors: Silvana Silvia
authors: SS
authors: Sandrone
authors: Biología Celular, Histología y Embriología, Facultad de Ciencias Médicas, INICSA (CONICET-Universidad Nacional de Córdoba), Córdoba, Argentina; Cátedra de Histología, Embriología y Genética, Universidad Nacional de La Rioja, La Rioja, Argentina.
authors: Gaston
authors: G
authors: Repossi
authors: Instituto de Investigaciones Biomédicas, Facultad de Medicina, Universidad de Buenos Aires, Ciudad de Buenos Aires, Argentina; CONICET-Universidad Nacional de Córdoba, Córdoba, Argentina.
authors: Marianela
authors: M
authors: Candolfi
authors: Biología Celular, Histología y Embriología, Facultad de Ciencias Médicas, INICSA (CONICET-Universidad Nacional de Córdoba), Córdoba, Argentina; CONICET-Universidad Nacional de Córdoba, Córdoba, Argentina. Electronic address: aeynard@gmail.com.
authors: Aldo Renato
authors: AR
authors: Eynard
mesh_terms: D000818:Animals; D004032:Diet; D005228:Fatty Acids, Essential / Q000378:metabolism / Q000627:therapeutic use*; D005909:Glioblastoma / Q000188:drug therapy; D005910:Glioma / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D050602:Linoleoyl-CoA Desaturase / Q000378:metabolism
chemical_list: D005228:Fatty Acids, Essential; D050602:Linoleoyl-CoA Desaturase
keywords: Central nervous system tumors; Essential fatty acids; Glioma treatment; Polyunsaturated fatty acids