title: Esophageal radioprotection by swallowed JP4-039/F15 in thoracic-irradiated mice with transgenic lung tumors.
abstract: OBJECTIVE
  To determine whether Gramicidin S (GS)-nitroxide, JP4-039, esophageal radiation protection protected lung tumors in a transgenic model, LoxP-Stoop-LoxP Kristen Rat Sarcoma Viral oncogene (LSL-K-RAS) mice were administered intra-tracheal- Carbapenem-resistant Enterobacteriaceae (CRE) recombinase, bilateral lung tumors were confirmed at 11 weeks, then thoracic irradiation was delivered.
  
  
  METHODS
  Mice received single-fraction 15 Gy or 24 Gy to both lungs, in subgroups receiving intraesophageal administration 10 min before irradiation of JP4-039 (in F15 emulsion) tumor size reduction and survival were investigated. Mice were followed for survival, and reduction in tumor size.
  
  
  RESULTS
  There was no evidence of tumor radioprotection in mice receiving JP4-039/F15.
  
  
  CONCLUSIONS
  Intraesophageal radioprotective small-molecule antioxidant therapy protects normal tissue but not tumor tissue in mice with transgenic lung tumors.
authors: Department of Radiation Oncology, UPCI Cancer Institute, Pittsburgh, PA, USA.
authors: Michael W
authors: MW
authors: Epperly
authors: Department of Radiation Oncology, UPCI Cancer Institute, Pittsburgh, PA, USA.
authors: Julie P
authors: JP
authors: Goff
authors: Department of Radiation Oncology, UPCI Cancer Institute, Pittsburgh, PA, USA.
authors: Darcy
authors: D
authors: Franicola
authors: Department of Radiation Oncology, UPCI Cancer Institute, Pittsburgh, PA, USA.
authors: Hong
authors: H
authors: Wang
authors: Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, U.S.A. Center for Chemical Methodologies & Library Development, University of Pittsburgh, Pittsburgh, PA, U.S.A.
authors: Peter
authors: P
authors: Wipf
authors: Department of Pharmaceutical Science, University of Pittsburgh, Pittsburgh, PA, U.S.A.
authors: Song
authors: S
authors: Li
authors: Department of Radiation Oncology, UPCI Cancer Institute, Pittsburgh, PA, USA greenbergerjs@upmc.edu.
authors: Joel S
authors: JS
authors: Greenberger
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004655:Emulsions; D004947:Esophagus / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D005260:Female; D011905:Genes, ras; D059765:Homologous Recombination; D019426:Integrases / Q000235:genetics; D008081:Liposomes; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000235:genetics / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D009589:Nitrogen Oxides / Q000008:administration & dosage* / Q000493:pharmacokinetics; D059351:Organ Sparing Treatments; D011837:Radiation-Protective Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics
chemical_list: D004655:Emulsions; C544775:JP4-039; D008081:Liposomes; D009589:Nitrogen Oxides; D011837:Radiation-Protective Agents; C045073:Cre recombinase; D019426:Integrases
keywords: GS-Nitroxide; esophageal radioprotection; transgenic lung cancer