title: Silica-encapsulated Gd3+-aggregated gold nanoclusters for in vitro and in vivo multimodal cancer imaging.
abstract: Gd(3+)-aggregated gold nanoclusters (AuNCs) encapsulated by silica shell (Gd(3+)-A-AuNCs@SiO2NPs) were strategically designed and prepared. The as-prepared nanoparticles exhibit aggregation-enhanced fluorescence (AEF), with an intensity that is up to 3.8 times that of discrete AuNCs. The clusters served as novel nanoprobes for in vitro and in vivo multimodal (fluorescence, magnetic resonance, and computed X-ray tomography) cancer imaging.
authors: Faculty of Chemistry, Northeast Normal University, Changchun, 130024 (P.R. China).
authors: Xiaotong
authors: X
authors: Wu
authors: Chunxia
authors: C
authors: Li
authors: Suchan
authors: S
authors: Liao
authors: Lu
authors: L
authors: Li
authors: Tingting
authors: T
authors: Wang
authors: Zhongmin
authors: Z
authors: Su
authors: Chungang
authors: C
authors: Wang
authors: Jihong
authors: J
authors: Zhao
authors: Changping
authors: C
authors: Sui
authors: Jun
authors: J
authors: Lin
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D005260:Female; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D008279:Magnetic Resonance Imaging; D053768:Metal Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D051379:Mice; D009369:Neoplasms / Q000175:diagnosis*; D061848:Optical Imaging; D012822:Silicon Dioxide / Q000737:chemistry; D014057:Tomography, X-Ray Computed
chemical_list: D005456:Fluorescent Dyes; D006046:Gold; D012822:Silicon Dioxide
keywords: aggregation-enhanced fluorescence; cancer; gold; multimodal imaging; nanoclusters