title: Maternal and neonatal outcomes after gonadotropin-releasing hormone agonist trigger for final oocyte maturation in patients undergoing in vitro fertilization.
abstract: OBJECTIVE
  To compare the rate of congenital anomalies, obstetrical complications, and neonatal complications in antagonist cycles where either GnRH agonist (GnRHa) or hCG was used for final oocyte maturation.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  University-based tertiary fertility center.
  
  
  METHODS
  Three hundred ninety-two women under 40 years of age who underwent controlled ovarian stimulation using a GnRH antagonist protocol and who had final oocyte maturation triggered with either a GnRHa or hCG that resulted in pregnancy and delivery after 16 weeks' gestation.
  
  
  METHODS
  GnRHa versus hCG trigger of final oocyte maturation.
  
  
  METHODS
  Congenital anomaly rates, obstetrical complications, and neonatal complications.
  
  
  RESULTS
  There were no significant differences in the rate of congenital anomalies between GnRHa and hCG trigger (6.6 vs. 9.2%). There were also no differences in the maternal complications (27.6 vs. 20.8%) or neonatal complications (19.7 vs. 20.0%) between the GnRHa trigger and hCG trigger groups.
  
  
  CONCLUSIONS
  GnRHa trigger does not affect the rate of congenital anomalies or obstetrical or neonatal complications and remains a viable option in the prevention of ovarian hyperstimulation syndrome.
authors: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Center for Advanced Reproductive Services, University of Connecticut Health Center, Farmington, Connecticut.
authors: Tara H
authors: TH
authors: Budinetz
authors: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Center for Advanced Reproductive Services, University of Connecticut Health Center, Farmington, Connecticut.
authors: Jessica S
authors: JS
authors: Mann
authors: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Center for Advanced Reproductive Services, University of Connecticut Health Center, Farmington, Connecticut.
authors: Daniel W
authors: DW
authors: Griffin
authors: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Center for Advanced Reproductive Services, University of Connecticut Health Center, Farmington, Connecticut.
authors: Claudio A
authors: CA
authors: Benadiva
authors: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Center for Advanced Reproductive Services, University of Connecticut Health Center, Farmington, Connecticut.
authors: John C
authors: JC
authors: Nulsen
authors: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Center for Advanced Reproductive Services, University of Connecticut Health Center, Farmington, Connecticut. Electronic address: lengmann@uchc.edu.
authors: Lawrence L
authors: LL
authors: Engmann
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use*; D005307:Fertilization in Vitro / Q000379:methods* / Q000706:statistics & numerical data; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists* / Q000037:antagonists & inhibitors; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008596:Menotropins / Q000627:therapeutic use; D009865:Oocytes / Q000187:drug effects / Q000502:physiology; D009866:Oogenesis / Q000187:drug effects; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D012189:Retrospective Studies
chemical_list: D006063:Chorionic Gonadotropin; D005300:Fertility Agents, Female; D007987:Gonadotropin-Releasing Hormone; D008596:Menotropins
keywords: GnRH agonist; IVF; OHSS; congenital anomalies; pregnancy outcomes