title: Comparison of bupivacaine moistened dressing and conventional dressing for pain relief on skin graft donor sites.
abstract: OBJECTIVE
  To compare the effectiveness of bupivacaine moistened dressing and conventional dressing in patients requiring split thickness skin graft for reconstruction of various defects.
  
  
  METHODS
  Randomized controlled trial.
  
  
  METHODS
  Department of Plastic Surgery and Burns Unit, Mayo Hospital, King Edward Medical University, Lahore, from January 2011 to January 2013.
  
  
  METHODS
  One hundred and fifty patients requiring split thickness skin grafting for various soft tissue defects were divided into two groups A and B, with 75 patients in each group. In Group A, skin graft donor site dressing was kept moist with 12 mL/100 cm2 of 0.25% bupivacaine solution and in Group B, dressing was moistened with same amount of normal saline. Outcome was measured by calculating rescue analgesia requirements in the two groups after 24 hours. Significance was determined by comparing analgesia sparing effect of each dressing using chi-square test.
  
  
  RESULTS
  In Group A, 5 out of 75 (6.7%) patients required rescue analgesia. In Group B, 72 out of 75 (96%) patients required rescue analgesia (p < 0.0001). There was 93.3% effectiveness of bupivacaine soaked dressing while only 4% effectiveness of conventional dressing.
  
  
  CONCLUSIONS
  Bupivacaine soaked dressing is much more effective in pain relief and in reducing the requirement of rescue analgesia, in early postoperative period, at split thickness skin graft donor site compared to the conventional dressing.
authors: Department of Plastic Surgery and Burn Unit, Mayo Hospital, KEMU, Lahore.
authors: Muhammad Sheraz
authors: MS
authors: Raza
authors: Department of Plastic Surgery and Burn Unit, Mayo Hospital, KEMU, Lahore.
authors: Tauqeer
authors: T
authors: Nazim
authors: Department of Plastic Surgery and Burn Unit, Mayo Hospital, KEMU, Lahore.
authors: Farid Ahmad
authors: FA
authors: Khan
mesh_terms: D000293:Adolescent; D000328:Adult; D000779:Anesthetics, Local / Q000627:therapeutic use*; D001458:Bandages; D002045:Bupivacaine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D059408:Pain Management; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D019651:Plastic Surgery Procedures; D016038:Skin Transplantation; D060053:Transplant Donor Site; D016896:Treatment Outcome; D014945:Wound Healing; D055815:Young Adult
chemical_list: D000779:Anesthetics, Local; D002045:Bupivacaine