title: [Pronostic value of parenchyma renal invasion of pT3 upper tract urinary carcinoma].
abstract: BACKGROUND
  Upper tract urinary carcinoma (UTUC) pT3 tumors are a heterogeneous entity including tumors invading the renal parenchyma, tumors with peripelvic fat invasion or peri-ureteral fat invasion. The aim of this study was to evaluate the prognostic significance of these three different groups of pT3 tumors.
  
  
  METHODS
  Between 1998 and 2012, 205 patients with UTUC were operated in two centers, including 52 patients with pT3 tumor stage. pT3 tumors were divided into three groups: peri-ureteral fat invasion (pT3U, n = 16), peripelvic fat invasion (pT3G, n = 21), and renal parenchyma invasion (pT3P, n = 15). The prognostic significance of the type of tumor infiltration was evaluated on specific and disease-free survival.
  
  
  RESULTS
  Median follow-up was 18.9 months [6-133.4]. In univariate analysis, renal parenchyma invasion was associated with a better prognostic in both specific (P = 0.026) and disease-free survival (P = 0.031) compared with peripelvic or peri-ureteral fat invasion. Mutivariate analysis retained the pT3 subgroup as an independant prognostic factor in both specific and disease-free survival (P = 0.02).
  
  
  CONCLUSIONS
  pT3 tumors with renal parenchyma invasion had a better prognosis than those with peripelvic or peri-ureteral fat invasion. The heterogeneity of the pT3 group should be taken into account to improve the care of patients.
authors: Service d'urologie, hôpital Bicêtre, université Paris-Sud Paris XI, 94270 Le Kremlin-Bicêtre, France.
authors: M
authors: M
authors: Bruzzi
authors: Service d'urologie, hôpital Bicêtre, université Paris-Sud Paris XI, 94270 Le Kremlin-Bicêtre, France. Electronic address: constance.legoux@gmail.com.
authors: C
authors: C
authors: Le Goux
authors: Service d'urologie, hôpital Bicêtre, université Paris-Sud Paris XI, 94270 Le Kremlin-Bicêtre, France.
authors: G
authors: G
authors: Pignot
authors: Service d'urologie, hôpital Cochin, université Paris Descartes Paris V, 75014 Paris, France.
authors: D
authors: D
authors: Amsellem-Ouazana
authors: Service d'anatomopathologie, hôpital Cochin, 75014 Paris, France.
authors: A
authors: A
authors: Vieillefond
authors: Service d'urologie, hôpital Bicêtre, université Paris-Sud Paris XI, 94270 Le Kremlin-Bicêtre, France.
authors: J-J
authors: JJ
authors: Patard
authors: Service d'urologie, hôpital Cochin, université Paris Descartes Paris V, 75014 Paris, France.
authors: M
authors: M
authors: Zerbib
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology*; D007680:Kidney Neoplasms / Q000473:pathology* / Q000601:surgery*; D007682:Kidney Pelvis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D014516:Ureteral Neoplasms / Q000473:pathology* / Q000601:surgery*
keywords: Facteur pronostique; Prognostic factor; Recurrence; Récidive; Survie; Survival; Tumeur de la voie excrétrice urinaire supérieure; Upper urinary tract; Urothelial carcinoma