title: Analysis of cefaclor in novel chocolate-based camouflage capsules.
abstract: The determination of cefaclor in a new, complex chocolate matrix was performed by using a simple sample preparation (dispersion in dilute hydrochloric acid at 80 degrees C, centrifugation, washing with cyclohexane), followed by ion pair HPLC on a Kinetex pentafluorophenyl core-shell stationary phase with UV detection at 265 nm. We obtained good linearity (R2 = 0.9976) and precision (average RSD 0.86%) for the relevant concentration range. The preparations, although hand-made in this pilot phase, showed good uniformity of content. After being stored for four weeks in a refrigerator the preparation did not contain recognizable amounts of decomposition products.
authors: F
authors: F
authors: Vetter
authors: J
authors: J
authors: Pohl
authors: B
authors: B
authors: Pohl
authors: F
authors: F
authors: Bracher
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002099:Cacao; D002214:Capsules; D002433:Cefaclor / Q000008:administration & dosage*; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D004304:Dosage Forms; D005780:Gelatin; D012015:Reference Standards; D015203:Reproducibility of Results; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000900:Anti-Bacterial Agents; D002214:Capsules; D004304:Dosage Forms; D002433:Cefaclor; D005780:Gelatin