title: Rotavirus vaccination compliance and completion in a Medicaid infant population.
abstract: We examined completion and compliance rates of rotavirus (RV) vaccination according to the recommendations of the Advisory Committee on Immunization Practices (ACIP) and the Food and Drug Administration approved Prescribing Information (PI) for Rotarix® (RV1, GlaxoSmithKline Vaccines) and RotaTeq® (RV5, Merck and Co.) among infants under one year of age covered by Medicaid programs. Healthcare claims data from state Medicaid programs that constituted the Truven Health MarketScan® Multi-State Medicaid Database were retrieved from May 2008-June 2012. Infants were grouped under PI and ACIP cohorts based on the dosing regimens followed. The overall compliance per PI (n=673,956) and ACIP (n=695,612) recommendations were 24.5% and 28.2%, respectively; completion rates were 30.3% and 32.6%, respectively. In the PI cohort, infants who received RV1 had significantly higher compliance as compared with infants who received RV5 (65.2% vs. 31.3%; p<0.0001); completion rates among infants receiving RV1 and RV5 were 65.3% and 46.4%, respectively (p<0.0001). In the ACIP cohort, compliance with RV1 was significantly higher than RV5 (68.8% vs. 45.9%; p<0.0001) as was the overall completion rate (73.5% vs. 48.8%; p<0.0001). While compliance is increasing year over year, overall compliance of RV vaccines is suboptimal, with over 40% of eligible infants unvaccinated in both populations. The 2-dose RV vaccine showed better completion rates and higher compliance than the 3-dose RV vaccine in the United States. Public health initiatives focusing on suboptimal compliance and completion rates of RV vaccination in the Medicaid population could improve these metrics, thereby offering protection against RV infection.
authors: USHO & MP, NAMA, GSK 5 Crescent Drive, Philadelphia, PA 19112, United States. Electronic address: girishanthy.x.krishnarajah@gsk.com.
authors: Girishanthy
authors: G
authors: Krishnarajah
authors: Truven Health Analytics, Ann Arbor, MI, United States.
authors: Pamela
authors: P
authors: Landsman-Blumberg
authors: Truven Health Analytics, Ann Arbor, MI, United States. Electronic address: elnara.eynullayeva@truvenhealth.com.
authors: Elnara
authors: E
authors: Eynullayeva
mesh_terms: D015331:Cohort Studies; D006801:Humans; D007223:Infant; D008484:Medicaid; D055118:Medication Adherence; D012189:Retrospective Studies; D012400:Rotavirus Infections / Q000453:epidemiology / Q000517:prevention & control*; D022243:Rotavirus Vaccines / Q000008:administration & dosage* / Q000276:immunology; D014481:United States / Q000453:epidemiology; D014611:Vaccination / Q000379:methods* / Q000706:statistics & numerical data*; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology
chemical_list: C492457:RIX4414 vaccine; C492535:RotaTeq; D022243:Rotavirus Vaccines; D014613:Vaccines, Attenuated
keywords: Completion; Compliance; Medicaid; Rotavirus; United States