title: PEG-Ursolic Acid Conjugate: Synthesis and In Vitro Release Studies.
abstract: A highly water-soluble macromolecular compound of ursolic acid with monomethoxypoly(ethylene glycol) (mPEG) was prepared. The physicochemical properties and stabilities under different conditions were investigated. By PEG conjugation, greatly increased water solubility was obtained, and the results showed that this conjugate was a potential prodrug for the oral delivery of ursolic acid.
authors: Department of Chemical and Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy.
authors: Marina
authors: M
authors: Zacchigna
authors: Department of Chemical and Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy.
authors: Francesca
authors: F
authors: Cateni
authors: Department of Chemical and Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy.
authors: Sara
authors: S
authors: Drioli
authors: Department of Chemical and Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy.
authors: Giuseppe
authors: G
authors: Procida
authors: School of Advanced Studies "G. D'Annunzio", University of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti Scalo, Chieti, Italy.
authors: Tiziano
authors: T
authors: Altieri
keywords: Conjugation; Monomethoxypoly(ethylene glycol); Solubility; Ursolic acid