title: Update on research and clinical translation on specific clinical areas: From bench to bedside: How insight in immune pathogenesis can lead to precision medicine of severe juvenile idiopathic arthritis.
abstract: Despite the enormous progress in the treatment of juvenile idiopathic arthritis (JIA), innovations based on true bench-to-bedside research, performed in JIA patients, are still scarce. This chapter describes novel developments in which clinical innovations go hand in hand with basic discoveries. For the purpose of this review, we will mainly focus on developments in severe forms of JIA, most notably systemic JIA and polyarticular JIA. However, also in less severe forms of JIA, such as oligoarticular JIA, better insight will help to improve diagnosis and treatment. Facilitating the transition from bench to bedside will prove crucial for addressing the major challenges in JIA management. If successful, it will set new standards for a safe, targeted and personalized therapeutic approach for children with JIA.
authors: Department of Pediatric Immunology, Centre for Molecular and Clinical Immunology (CMCI), Laboratory for Translational Medicine, University Medical Centre Utrecht, Lundlaan 6/P.O. Box 85090, 3584 EA/3508 AB Utrecht, The Netherlands. Electronic address: b.vastert@umcutrecht.nl.
authors: Sebastiaan
authors: S
authors: Vastert
authors: Department of Pediatric Immunology, Centre for Molecular and Clinical Immunology (CMCI), Laboratory for Translational Medicine, University Medical Centre Utrecht, Lundlaan 6/P.O. Box 85090, 3584 EA/3508 AB Utrecht, The Netherlands.
authors: Berent
authors: B
authors: Prakken
mesh_terms: D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001171:Arthritis, Juvenile / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D015415:Biomarkers / Q000097:blood; D002648:Child; D006801:Humans; D020382:Interleukin-18 / Q000097:blood; D007378:Interleukins / Q000502:physiology*; D057285:Precision Medicine; D057170:Translational Research, Biomedical
chemical_list: D018501:Antirheumatic Agents; D015415:Biomarkers; D020382:Interleukin-18; D007378:Interleukins
keywords: Bench to bedside; JIA; Personalized medicine; Translational research