title: [Head to head comparison of two currently used nomograms predicting the risk of side specific extra capsular extension to indicate nerve sparing during radical prostatectomy for treatment of prostate cancer].
abstract: OBJECTIVE
  To perform a head to head comparison of these two nomograms by an external validation combined with an identification of probability cut-offs when to indicate NS.
  
  
  METHODS
  The full models of the nomograms of Ohori et al. and Steuber et al. were used to calculate the risk of ECE based on PSA and side specific information on clinical stage, biopsy Gleason score, % positive cores, and % cancer in cores. A dataset of 968 prostate half lobes was used retrospectively for analysis. All patients underwent laparoscopic robot-assisted or open radical prostatectomy for localized prostate cancer.
  
  
  RESULTS
  The predictive accuracy of the Ohori nomogram was at 0.80 and for the Steuber Nomogram at 0.78 (comparison P > 0.05). In the calibration plot, the Ohori nomogram showed less departures from ideal predictions than the Steuber nomogram. The best probability cut-off to allow NS for the Ohori nomogram seemed to be ≤ 10%, permitting NS in 59.7% of all cases and being associated with a false negative rate of 10%. The best cut-off for the Steuber nomogram seemed to be ≤ 8%, permitting NS in 44% and associated with a false negative rate 12.5%.
  
  
  CONCLUSIONS
  The Ohori et al. and the Steuber et al. nomograms allow highly accurate and comparable predictions of the risk of side specific ECE.
  
  
  METHODS
  4.
authors: Service d'urologie, hôpital Nord, chemin des Bourrelys, 13015 Marseille, France; Aix-Marseille université, 13284 Marseille, France. Electronic address: c.clement13@hotmail.fr.
authors: C
authors: C
authors: Clement
authors: Aix-Marseille université, 13284 Marseille, France; Service d'urologie et transplantation rénale, hôpital La Conception, AP-HM, 13385 Marseille, France.
authors: C
authors: C
authors: Maurin
authors: Service d'anatomo-pathologie, hôpital Nord, 13015 Marseille, France.
authors: J
authors: J
authors: Villeret
authors: Service d'anatomo-pathologie, institut Paoli-Calmettes, 13009 Marseille, France.
authors: M
authors: M
authors: Marcy
authors: Service de radiothérapie, institut Paoli-Calmettes, 13009 Marseille, France.
authors: N
authors: N
authors: Salem
authors: Service de radiologie, institut Paoli-Calmettes, 13009 Marseille, France.
authors: S
authors: S
authors: Brunelle
authors: Service d'oncologie, institut Paoli-Calmettes, 13009 Marseille, France.
authors: G
authors: G
authors: Gravis
authors: Service d'anatomo-pathologie, hôpital Nord, 13015 Marseille, France.
authors: S
authors: S
authors: Garcia
authors: Service d'anatomo-pathologie, hôpital Nord, 13015 Marseille, France.
authors: S
authors: S
authors: Giusiano
authors: Service d'urologie, hôpital Nord, chemin des Bourrelys, 13015 Marseille, France.
authors: C
authors: C
authors: Bastide
authors: Service d'urologie, hôpital Nord, chemin des Bourrelys, 13015 Marseille, France.
authors: D
authors: D
authors: Rossi
authors: Service d'urologie, Jewish hospital, QC H3TIE2 Montreal, Canada.
authors: F
authors: F
authors: Bladou
authors: Service d'urologie, institut Paoli-Calmettes, 13009 Marseille, France.
authors: J
authors: J
authors: Walz
mesh_terms: D000368:Aged; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D049451:Nomograms; D011379:Prognosis; D011468:Prostatectomy / Q000379:methods*; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery*; D012189:Retrospective Studies; D018570:Risk Assessment
keywords: Cancer de la prostate; Conservation nerveuse; Extension extra-capsulaire; Extra capsular extension; Nerve sparing; Nomogram; Nomogrammes; Prediction; Prostate cancer; Prostatectomie; Prostatectomy; Prédiction; T3; Validation