title: The role of ghrelin in neuroprotection after ischemic brain injury.
abstract: Ghrelin, a gastrointestinal peptide with a major role in regulating feeding and metabolism, has recently been investigated for its neuroprotective effects. In this review we discuss pre-clinical evidence suggesting ghrelin may be a useful therapeutic in protecting the brain against injury after ischemic stroke. Specifically, we will discuss evidence showing ghrelin administration can improve neuronal cell survival in animal models of focal cerebral ischemia, as well as rescue memory deficits. We will also discuss its proposed mechanisms of action, including anti-apoptotic and anti-inflammatory effects, and suggest ghrelin treatment may be a useful intervention after stroke in the clinic.
authors: School of Health Sciences and Health Innovations Research Institute (HIRi), RMIT University, Melbourne, VIC 3083, Australia. Sarah.Spencer@rmit.edu.au.
authors: Sarah J
authors: SJ
authors: Spencer
authors: Department of Pharmacology, Faculty of Medicine, Monash University, Melbourne, VIC 3800, Australia. alyson.miller@monash.edu.
authors: Alyson A
authors: AA
authors: Miller
authors: Department of Physiology, Faculty of Medicine, Monash University, Melbourne, VIC 3800, Australia. zane.andrews@monash.edu.
authors: Zane B
authors: ZB
authors: Andrews