title: Development of GI-safe NSAID; progression from the bark of willow tree to modern pharmacology.
abstract: Non-steroidal anti-inflammatory drugs (NSAIDs) have been used for analgesic, anti-inflammatory and antithrombotic actions and recently for cancer prevention, but they carries a risk of major gastroduodenal damages from symptomatic ulcers to serious complications leading to fatal outcomes. Therefore, the novel strategies to rescue long-term NSAID requiring patients from NSAID-associated gastroduodenal damages are essential. Besides of current drugs based on classic damaging mechanisms attributable to the decline of gastric mucosal prostaglandin synthesis, reductions of mucosal blood flow, attenuated bicarbonate secretion and mucus synthesis related with prostaglandin levels, effective therapeutics targeted for update mechanisms of NSAID-induced gastroduodenal damages are introduced in this paper based on recent advances in basic science and biotechnology exploring deeper molecular mechanisms of NSAID-induced gastroduodenal damage beyond COX inhibition.
authors: CHA Cancer Prevention Research Center, CHA Cancer Institute, CHA University, Seoul 135-081, Republic of Korea.
authors: Napapan
authors: N
authors: Kangwan
authors: CHA Cancer Prevention Research Center, CHA Cancer Institute, CHA University, Seoul 135-081, Republic of Korea.
authors: Jong Min
authors: JM
authors: Park
authors: CHA Cancer Prevention Research Center, CHA Cancer Institute, CHA University, Seoul 135-081, Republic of Korea; CHA University Bundang Medical Center, Digestive Disease Center, Seongnam 463-712, Republic of Korea. Electronic address: hahmkb@cha.ac.kr.
authors: Ki Baik
authors: KB
authors: Hahm
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D005753:Gastric Mucosa / Q000187:drug effects; D006801:Humans; D007410:Intestinal Diseases / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control; D024301:Plant Bark; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use; D032108:Salix
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D020011:Protective Agents