title: Use of preservative-free hyaluronic acid (Hylabak(®)) for a range of patients with dry eye syndrome: experience in Russia.
abstract: Artificial tear preparations are important in the management of dry eye syndrome. We present the findings from four recently published studies conducted in Russia assessing Hylabak(®) (marketed as Hyabak(®) in Europe), a preservative-free hyaluronic acid preparation, for the treatment of dry eye syndrome. All studies had an open, noncomparative design, but one compared the findings with those from 25 patients treated with Tear Naturale(®) in previous studies. A total of 134 children and adults were enrolled, and the etiologies of dry eye syndrome included contact lens use, intensive office work, adenovirus eye infection, postmenopausal status, persistent meibomian blepharitis, Sjögren's syndrome, phacoemulsification with intraocular lens implantation, and refractive surgery. The patients were treated with Hylabak for 2 weeks to 2 months. All studies showed that Hylabak resulted in marked improvement as assessed by subjective sensations/complaints, Schirmer's test, Norn's test, impression cytology and biomicroscopy, staining, and tear osmolarity. Greater benefits were also reported compared with Tear Naturale, including a faster onset of action. Hylabak was well tolerated. In conclusion, Hylabak provided rapid and safe relief from the signs and symptoms of dry eye syndrome, as well as improvement in objective measures, in a wide range of patients.
authors: Department of Ophthalmology, Pediatric State Medical Academy, Saint Petersburg, Russia.
authors: Vladimir Vsevolodovich
authors: VV
authors: Brjesky
authors: Moscow Research Institute of Eye Diseases, Moscow, Russia.
authors: Yury Fedorovich
authors: YF
authors: Maychuk
authors: Department of Ophthalmology, Volgograd State Medical University, Volgograd, Russia.
authors: Alexey Vladimirovich
authors: AV
authors: Petrayevsky
authors: Novosibirsk Branch of the Federal State Institute MNTK Eye Microsurgery, Novosibirsk, Russian Federation, Russia.
authors: Peter Gerrievich
authors: PG
authors: Nagorsky
keywords: Hylabak®; artificial tears; dry eye; eye drops; hyaluronic acid; preservative-free