title: Comparative genetics of longevity and cancer: insights from long-lived rodents.
abstract: Mammals have evolved a remarkable diversity of ageing rates. Within the single order of Rodentia, maximum lifespans range from 4 years in mice to 32 years in naked mole rats. Cancer rates also differ substantially between cancer-prone mice and almost cancer-proof naked mole rats and blind mole rats. Recent progress in rodent comparative biology, together with the emergence of whole-genome sequence information, has opened opportunities for the discovery of genetic factors that control longevity and cancer susceptibility.
authors: University of Rochester, Rochester, New York 14627, USA.
authors: Vera
authors: V
authors: Gorbunova
authors: University of Rochester, Rochester, New York 14627, USA.
authors: Andrei
authors: A
authors: Seluanov
authors: Albert Einstein College of Medicine, Bronx, New York 10461, USA.
authors: Zhengdong
authors: Z
authors: Zhang
authors: Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors: Vadim N
authors: VN
authors: Gladyshev
authors: Albert Einstein College of Medicine, Bronx, New York 10461, USA.
authors: Jan
authors: J
authors: Vijg
mesh_terms: D000375:Aging / Q000235:genetics; D000818:Animals; D056726:Genetic Association Studies; D008136:Longevity / Q000235:genetics*; D051379:Mice; D009369:Neoplasms / Q000235:genetics*; D051381:Rats; D012377:Rodentia; D013045:Species Specificity