title: Biological evaluation and SAR analysis of O-methylated analogs of quercetin as inhibitors of cancer cell proliferation.
abstract: Using a high-throughout screening approach, the anticancer activities of 16 O-methylated (OMe) analogs of quercetin were assessed. The structure-activity relationships showed that OMe moieties at the 4' and/or 7 positions were important for maintaining inhibitory activities against the 16 cancer cell lines. Furthermore, when the OH groups at the 3' and 4' positions were both replaced by OMe moieties, anticancer activity was enhanced.
authors: National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210023, China; Department of Organic Chemistry, China Pharmaceutical University, Nanjing, Jiangsu, 211198, China.
authors: Zhi-Hao
authors: ZH
authors: Shi
authors: Nian-Guang
authors: NG
authors: Li
authors: Yu-Ping
authors: YP
authors: Tang
authors: Qian-Ping
authors: QP
authors: Shi
authors: Hao
authors: H
authors: Tang
authors: Wei
authors: W
authors: Li
authors: Xu
authors: X
authors: Zhang
authors: Hai-An
authors: HA
authors: Fu
authors: Jin-Ao
authors: JA
authors: Duan
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008745:Methylation; D015394:Molecular Structure; D009369:Neoplasms / Q000473:pathology*; D011794:Quercetin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D011794:Quercetin
keywords: analog; anticancer; methylation; quercetin; structure-activity relationship