title: Patterns of cortical activation following motor tasks and psychological-inducing movie cues in heroin users: an fMRI study.
abstract: OBJECTIVE
  Drug abuse and addiction are worldwide health problems. However, few studies have used fMRI to investigate the effect of chronic heroin use on brain activation. This is a study along this line.
  
  
  METHODS
  fMRI positive sites in the brain were recorded during different motor and sensory activities.
  
  
  RESULTS
  Following motor activities, heroin users had more sites globally activated in the brain than in normal volunteers, with ex-heroin users being least reactive. Conversely, a "heroin puffing" movie produced more activation in ongoing-heroin and ex-heroin users than in the normal individuals, whereas a movie with explicit sexual content was less stimulatory in both groups of heroin users compared to normal individuals.
  
  
  CONCLUSIONS
  These significant findings relative to the function of specific brain nuclei are discussed.
authors: Yan-Ling
authors: YL
authors: Jiang
authors: Wei
authors: W
authors: Tian
authors: Gang
authors: G
authors: Lu
authors: John A
authors: JA
authors: Rudd
authors: K F
authors: KF
authors: Lai
authors: L Y
authors: LY
authors: Yeung
authors: Maria S M
authors: MS
authors: Wai
authors: Yuan Yuan
authors: YY
authors: Li
authors: Ming Long
authors: ML
authors: Huang
authors: David T
authors: DT
authors: Yew
mesh_terms: D000328:Adult; D001143:Arousal / Q000187:drug effects* / Q000502:physiology*; D001288:Attention / Q000187:drug effects / Q000502:physiology; D001931:Brain Mapping; D002531:Cerebellum / Q000187:drug effects / Q000503:physiopathology; D002540:Cerebral Cortex / Q000187:drug effects* / Q000503:physiopathology*; D003337:Corpus Callosum / Q000187:drug effects / Q000503:physiopathology; D003463:Cues; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D005260:Female; D003932:Heroin / Q000494:pharmacology*; D006556:Heroin Dependence / Q000503:physiopathology* / Q000534:rehabilitation; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009040:Motion Pictures; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology; D011434:Proprioception / Q000187:drug effects / Q000502:physiology; D012016:Reference Values
chemical_list: D003932:Heroin