title: Sex-specific association of RANTES gene -403 variant in Meniere's disease.
abstract: Several studies have shown the correlation between RANTES gene and inflammatory disorders; the aim of the present study was to investigate the association between RANTES promoter gene polymorphism and Meniere's disease (MD) in an Iranian population. In this study patients with MD comprising definite MD (N = 56) and probable MD (N = 15) were selected according to diagnostic criteria of AAO-HNS. The control group (N = 101) were healthy normal subjects who did not have a history of ear disease and vertigo. PCR-RFLP for RANTES -403G>A has been performed. We found a protective role for RANTES -403A allele in male group in our population. None of the male patients with MD were carrier of allele A which was significantly different from the presence of allele A in the male control group (AA+GA vs. GG: p = 0.0004, OR 0.05, 95 % CI 0.001-0.39). This difference was not significant in female group. There was no significant association between RANTES gene polymorphism and the level of hearing loss. our results showed a sex-specific association between RANTES gene polymorphism and MD but more studies are necessary to further assess this association.
authors: Otorhinolaryngology Research Center, Amir-Alam Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
authors: Nasrin
authors: N
authors: Yazdani
authors: Marzieh
authors: M
authors: Mojbafan
authors: Motahareh
authors: M
authors: Taleba
authors: Parvin
authors: P
authors: Amiri
authors: Farzaneh
authors: F
authors: Nejadian
authors: Mohammadtaghi Khorsandi
authors: MK
authors: Ashtiani
authors: Mahsa M
authors: MM
authors: Amoli
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D018946:Chemokine CCL5 / Q000235:genetics*; D005260:Female; D006801:Humans; D007492:Iran; D008297:Male; D008575:Meniere Disease / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D011401:Promoter Regions, Genetic; D012737:Sex Factors
chemical_list: C483024:CCL5 protein, human; D018946:Chemokine CCL5