title: [A twelve-years-old girl with multiloculated gynandroblastoma CD99 negative: case report].
abstract: The ginandroblastoma is an extremely rare ovarian tumor which shows components of granulosa cells and Sertoli/Leydig cells. We describe a case of a twelve-years-old girl who presented abnormal uterine bleeding and progressively growing intraabdominal mass associated with menorrhagia, CA-125 60.4 UI/mL and extension studies reporting cystic mass in the left ovary. She underwent oophorectomy. Pathological study shows a multilocular tumor filled with serous material. Many Call-Exner bodies were observed in the histopathological analysis, 45% of Sertoli/Leydig cells. Immunohistochemistry was reactive for inhibin, calretinin and pCK while AE1/AE3 and CD99 markers were negative. This is the first case report about a multiloculated gynandroblastoma, negative for CD99 in a 12-years-old girl. Thus, the study of this clinical case represents a systematic approach for tumors of the sex cord cells.
authors: Grupo de Patología Estructural, Funcional y Clínica, Universidad Industrial de Santander.
authors: Jairo Alonso
authors: JA
authors: Sierra-Avendaño
authors: Grupo de Patología Estructural, Funcional y Clínica, Universidad Industrial de Santander.
authors: Ricardo
authors: R
authors: García-Pino
authors: Grupo de Patología Estructural, Funcional y Clínica, Universidad Industrial de Santander.
authors: Gabriel Eduardo
authors: GE
authors: Pérez-García
mesh_terms: D000071443:12E7 Antigen; D015703:Antigens, CD / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D015815:Cell Adhesion Molecules / Q000097:blood*; D002648:Child; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000097:blood* / Q000473:pathology; D018312:Sex Cord-Gonadal Stromal Tumors / Q000097:blood* / Q000473:pathology
chemical_list: D000071443:12E7 Antigen; D015703:Antigens, CD; D014408:Biomarkers, Tumor; C061828:CD99 protein, human; D015815:Cell Adhesion Molecules