title: Science to practice: Cellular therapy of Parkinson disease--a new radiotracer to target transplanted dopaminergic cells with PET.
abstract: The article by Bu and colleagues (1) introduces N-[2-(diethylamino)ethyl]-(18)F-5-fluoropicolinamide ((18)F-P3BZA) as a promising positron emission tomography (PET) radiotracer to target transplanted porcine retinal pigment epithelial (pRPE) cells in the striatum. This strategy to monitor cellular therapy of Parkinson disease has a high translational potential and in the future may help us to better understand some of the controversial results reported in clinical trials.
authors: Department of Experimental Molecular Imaging, RWTH Aachen University Pauwelsstrasse 20 52074 Aachen, Germany.
authors: Fabian
authors: F
authors: Kiessling
mesh_terms: D000818:Animals; D005260:Female; D005462:Fluorine Radioisotopes / Q000493:pharmacokinetics*; D057054:Molecular Imaging / Q000379:methods*; D064847:Multimodal Imaging; D010300:Parkinson Disease / Q000628:therapy*; D010848:Picolinic Acids / Q000493:pharmacokinetics*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D055213:Retinal Pigment Epithelium / Q000637:transplantation*; D014057:Tomography, X-Ray Computed
chemical_list: D005462:Fluorine Radioisotopes; C000591167:N-(2-(diethylamino)ethyl)-5-fluoropicolinamide; D010848:Picolinic Acids; D019275:Radiopharmaceuticals