title: Copper-catalyzed enantioselective hetero-Diels-Alder reaction of Danishefsky's diene with β,γ-unsaturated α-ketoesters.
abstract: A highly enantioselective hetero-Diels-Alder reaction of Danishefsky's diene with β,γ-unsaturated α-ketoesters was developed for the first time by virtue of chiral copper complexes. This protocol provided a facile access to optically active dihydropyranones bearing a quaternary center with high enantioselectivities and good yields. Furthermore, on the basis of the isolated intermediate analysis, the reaction pathway was substrate-dependent.
authors: Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry & Collaborative Innovation Center of Suzhou Nano Science and Technology, University of Science and Technology of China , Hefei, Anhui 230026, P. R. China.
authors: Yanbin
authors: Y
authors: Hu
authors: Kun
authors: K
authors: Xu
authors: Sheng
authors: S
authors: Zhang
authors: Fengfeng
authors: F
authors: Guo
authors: Zhenggen
authors: Z
authors: Zha
authors: Zhiyong
authors: Z
authors: Wang