title: Replication of SULT4A1-1 as a pharmacogenetic marker of olanzapine response and evidence of lower weight gain in the high response group.
abstract: OBJECTIVE
  Antipsychotic efficacy biomarkers have the potential to improve outcomes in psychotic patients. This study examined the effect of SULT4A1-1 haplotype status (rs2285162 [A]-rs2285167 [G]) on olanzapine response.
  
  
  METHODS
  We evaluated 87 olanzapine treated subjects from Phases 1, 1B and 2 of the CATIE trial for the impact of SULT4A1-1 status on change in Positive and Negative Syndrome Scale (PANSS) total score using two models of response. We also examined weight change.
  
  
  RESULTS
  SULT4A1-1-positive status correlated with superior olanzapine response in Phase 1 (p = 0.004 for model 1 and p = 0.001 for model 2) and Phases 1B/2 (p = 0.05 for model 1 and p = 0.007 for model 2). SULT4A1-1-positive subjects gained significantly less weight per month on olanzapine, 0.15 lbs, than did SULT4A1-1-negative subjects, 2.27 lbs (p = 0.04).
  
  
  CONCLUSIONS
  This study provides a second replication of superior olanzapine response in SULT4A1-1-positive subjects compared with SULT4A1-1-negative subjects. SULT4A1-1-positive subjects treated with olanzapine also gained less weight than SULT4A1-1-negative subjects.
authors: SureGene, LLC, 600 Envoy Circle, Louisville, KY 40299, USA.
authors: Timothy L
authors: TL
authors: Ramsey
authors: Qian
authors: Q
authors: Liu
authors: Mark D
authors: MD
authors: Brennan
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects; D001569:Benzodiazepines / Q000008:administration & dosage* / Q000009:adverse effects; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077152:Olanzapine; D010597:Pharmacogenetics; D015238:Sulfotransferases / Q000235:genetics*; D015430:Weight Gain / Q000187:drug effects / Q000235:genetics*
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; C479953:SULT4A1 protein, human; D015238:Sulfotransferases; D000077152:Olanzapine
keywords: CATIE trial; antipsychotic response; biomarker; weight gain