title: Acid-coated Textiles (pH 5.5-6.5)--a New Therapeutic Strategy for Atopic Eczema?
abstract: Increased transepidermal water loss (TEWL) and decreased skin capacitance are characteristic features of the disturbed epidermal barrier in atopic eczema (AE). The "acid mantle", which is a slightly acidic film on the surface of the skin has led to the development of acidic emollients for skin care. In this context, the effect of citric acid-coated textiles on atopic skin has not been examined to date. A textile carrier composed of cellulose fibres was coated with a citric acid surface layer by esterification, ensuring a constant pH of 5.5-6.5. Twenty patients with AE or atopic diathesis were enrolled in the study. In a double-blind, half-side experiment, patients had to wear these textiles for 12 h a day for 14 days. On day 0 (baseline), 7 and 14, tolerability (erythema, pruritus, eczema, wearing comfort) and efficacy on skin barrier were assessed by TEWL skin hydration (corneometry/capacitance), pH and clinical scoring of eczema (SCORAD). Citric acid-coated textiles were well tolerated and improved eczema and objective parameters of skin physiology, including barrier function and a reduced skin surface pH, with potential lower pathogenic microbial colonisation.
authors: Department of Dermatology and Allergy, Biederstein, Technische Universität München, DE-80802 Munich, Germany. teresa.jaeger@lrz.tu-muenchen.de.
authors: Teresa
authors: T
authors: Jaeger
authors: Markus
authors: M
authors: Rothmaier
authors: Holger
authors: H
authors: Zander
authors: Johannes
authors: J
authors: Ring
authors: Jan
authors: J
authors: Gutermuth
authors: Mark D
authors: MD
authors: Anliker
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002482:Cellulose; D019343:Citric Acid / Q000008:administration & dosage* / Q000009:adverse effects; D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000503:physiopathology; D004198:Disease Susceptibility / Q000503:physiopathology; D004311:Double-Blind Method; D004337:Drug Carriers; D025802:Electric Capacitance; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000737:chemistry / Q000503:physiopathology; D013784:Textiles; D014870:Water Loss, Insensible / Q000187:drug effects; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D019343:Citric Acid; D002482:Cellulose