title: Efficacy and Tolerability of Clarema 1% Cream and Hirudoid 40000 U.APTT Gel in the Topical Treatment of Haematomas and/or Subcutaneous Haematic Extravasations.
abstract: Ninety-six caucasian both-gender patients with haematomas and/or subcutaneous haematic extravasation of traumatic or surgical origin were randomized to receive local treatment (max 10 days) with heparan sulfate cream or glycosaminoglycan-polysulphate (GAGPS) gel. Signs (oedema, disability, and colour of the lesion) and symptoms (pain at rest and at movement) (scored 0-3), the sum of the scores (primary end point), and the size of the lesion were evaluated at the baseline visit and afterwards every 5 days. The rate of the patients completely healed at the end of the study was also recorded. The results of the study showed that heparan sulfate 1% cream was comparable or superior to GAGPS gel in relieving signs and symptoms. No AEs were recorded.
authors: Sport Medicine and Traumatology Unit, Lucca General Hospital, 55100 Lucca, Italy.
authors: Tiziana
authors: T
authors: Polieri
authors: Sport Medicine and Traumatology Unit, Lucca General Hospital, 55100 Lucca, Italy.
authors: Enrico
authors: E
authors: Orsoni
authors: Sport Medicine and Traumatology Unit, Lucca General Hospital, 55100 Lucca, Italy.
authors: Giorgio
authors: G
authors: Saponati
authors: Sport Medicine and Traumatology Unit, Lucca General Hospital, 55100 Lucca, Italy.
authors: Enrico
authors: E
authors: Castellacci