title: Evaluation of selective positron emission tomography template method for spatial normalization of amyloid imaging with 11C-Pittsburgh Compound B.
abstract: OBJECTIVE
  Spatial normalization of C-Pittsburgh Compound B (PiB) images is challenging for an automatic quantitative analysis without magnetic resonance imaging (MRI) because of different distribution patterns between amyloid positive and negative images. To overcome this issue, we evaluated a selective positron emission tomography template (SPT) method.
  
  
  METHODS
  Three sets of single positron emission tomography templates were created: PiB negative template, PiB positive template, and mixed template. Sixty-one patients with dementia were enrolled as the validation cohort. Magnetic resonance imaging-aided normalization method was used as a reference. The SPT method was based on visual classification (positive, negative, and equivocal). The optimal templates for each visual group were determined by correlation values and average percent errors (APEs) with MRI-aided normalization. The results of the SPT and the single template methods were compared with those of MRI-aided normalization in terms of correlation values, APEs, and concordance rates.
  
  
  RESULTS
  The SPT (PiB negative template for the negative and equivocal groups and PiB positive template for the positive group) showed higher correlations and concordance rate and lower APEs with MRI-aided normalization than did the single template.
  
  
  CONCLUSIONS
  Use of the SPT provides accurate normalization of amyloid images without MRI.
authors: From the Departments of *Nuclear Medicine, and †Neurology, Asan Medical Center, University of Ulsan College of Medicine; and ‡Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors: Sun Young
authors: SY
authors: Chae
authors: Hye Ok
authors: HO
authors: Kim
authors: Minyoung
authors: M
authors: Oh
authors: Dong Yun
authors: DY
authors: Lee
authors: Soyoung
authors: S
authors: Jin
authors: Seung Jun
authors: SJ
authors: Oh
authors: Jae Hong
authors: JH
authors: Lee
authors: Duk L
authors: DL
authors: Na
authors: Sang Won
authors: SW
authors: Seo
authors: Chong Sik
authors: CS
authors: Lee
authors: Jae Seung
authors: JS
authors: Kim
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000378:metabolism*; D000682:Amyloid / Q000378:metabolism*; D000814:Aniline Compounds; D002250:Carbon Radioisotopes; D005260:Female; D006801:Humans; D008297:Male; D049268:Positron-Emission Tomography / Q000379:methods*; D013844:Thiazoles
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000682:Amyloid; D000814:Aniline Compounds; D002250:Carbon Radioisotopes; D013844:Thiazoles