title: PKM2: the thread linking energy metabolism reprogramming with epigenetics in cancer.
abstract: Cancer metabolism reprogramming or alterations in epigenetics are linked to an incidence of cancer. It is apparent that epigenetic changes have been found in tumors, therefore, the complete epigenome and entire pathways relevant to cell metabolism are subject to epigenetic dysregulation. Here, we review the pyruvate kinase M2 (PKM2) isoform, a glycolytic enzyme involved in ATP generation and pyruvate production, which plays an essential role in tumor metabolism and growth, and also functions as a protein kinase that phosphorylates histones during genes transcription and chromatin remodeling. We also discuss the potential role of PKM2 in the dynamic integration between metabolic reprogramming and alterations in epigenetics during carcinogenesis and cancer progression.
authors: Cancer Research Institute, Central South University, Changsha 410078, China. linglinginbeijing@gmail.com.
authors: Ling
authors: L
authors: Chen
authors: Cancer Research Institute, Central South University, Changsha 410078, China. okoyo@163.com.
authors: Ying
authors: Y
authors: Shi
authors: Center for Medicine Research, Xiangya Hospital, Central South University, Changsha 410008, China. taoyong@csu.edu.cn.
authors: Shuang
authors: S
authors: Liu
authors: Cancer Research Institute, Central South University, Changsha 410078, China. ycao98@csu.edu.cn.
authors: Ya
authors: Y
authors: Cao
authors: Cancer Research Institute, Central South University, Changsha 410078, China. wangxiang@csu.edu.cn.
authors: Xiang
authors: X
authors: Wang
authors: Cancer Research Institute, Central South University, Changsha 410078, China. taoyong@csu.edu.cn.
authors: Yongguang
authors: Y
authors: Tao
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000235:genetics* / Q000378:metabolism; D065150:Cellular Reprogramming; D042002:Chromatin Assembly and Disassembly; D004734:Energy Metabolism; D006801:Humans; D011770:Pyruvate Kinase / Q000235:genetics / Q000378:metabolism*
chemical_list: D011770:Pyruvate Kinase