title: Beyond standard image-enhanced endoscopy confocal endomicroscopy.
abstract: Endomicroscopy is a new imaging tool for gastrointestinal endoscopy. In vivo histology becomes possible at subcellular resolution during ongoing colonoscopy. Panchromoendoscopy with targeted biopsies has become the method of choice for surveillance of patients with inflammatory bowel disease. Endomicroscopy can be added after chromoendoscopy to clarify whether standard biopsies are needed. This smart biopsy concept can increase the diagnostic yield of intraepithelial neoplasia and substantially reduce the need for biopsies. Clinical acceptance is increasing because of a multitude of positive studies about the diagnostic value of endomicroscopy. Smart biopsies, functional imaging, and molecular imaging may represent the future for endomicroscopy.
authors: Department for Internal Medicine, Gastroenterology and Oncology, St Marienkrankenhaus, Richard-Wagner-Street, 14, Frankfurt 60318, Germany.
authors: Daniel
authors: D
authors: Teubner
authors: Department for Internal Medicine, Gastroenterology and Oncology, St Marienkrankenhaus, Richard-Wagner-Street, 14, Frankfurt 60318, Germany. Electronic address: info@ralf-kiesslich.de.
authors: Ralf
authors: R
authors: Kiesslich
authors: Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors: Takayuki
authors: T
authors: Matsumoto
authors: Department for Internal Medicine, Gastroenterology and Oncology, St Marienkrankenhaus, Richard-Wagner-Street, 14, Frankfurt 60318, Germany.
authors: Johannes W
authors: JW
authors: Rey
authors: Department for Internal Medicine, Gastroenterology and Oncology, St Marienkrankenhaus, Richard-Wagner-Street, 14, Frankfurt 60318, Germany.
authors: Arthur
authors: A
authors: Hoffman
mesh_terms: D048588:Benzoxazines; D001706:Biopsy / Q000379:methods; D003113:Colonoscopy / Q000379:methods*; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*; D004396:Coloring Agents; D016099:Endoscopy, Gastrointestinal / Q000379:methods; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D015212:Inflammatory Bowel Diseases / Q000150:complications / Q000473:pathology*; D018613:Microscopy, Confocal / Q000379:methods; D011230:Precancerous Conditions / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*
chemical_list: D048588:Benzoxazines; D004396:Coloring Agents; C028911:cresyl violet
keywords: Chromoendoscopy; Confocal endomicroscopy; IBD