title: Auditory-prefrontal axonal connectivity in the macaque cortex: quantitative assessment of processing streams.
abstract: Primate sensory systems subserve complex neurocomputational functions. Consequently, these systems are organised anatomically in a distributed fashion, commonly linking areas to form specialised processing streams. Each stream is related to a specific function, as evidenced from studies of the visual cortex, which features rather prominent segregation into spatial and non-spatial domains. It has been hypothesised that other sensory systems, including auditory, are organised in a similar way on the cortical level. Recent studies offer rich qualitative evidence for the dual stream hypothesis. Here we provide a new paradigm to quantitatively uncover these patterns in the auditory system, based on an analysis of multiple anatomical studies using multivariate techniques. As a test case, we also apply our assessment techniques to more ubiquitously-explored visual system. Importantly, the introduced framework opens the possibility for these techniques to be applied to other neural systems featuring a dichotomised organisation, such as language or music perception.
authors: Rotman Research Institute of Baycrest Centre, University of Toronto, Toronto, Ontario M6A 2E1, Canada; Department of Neuroinformatics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6525 AJ Nijmegen, The Netherlands; C. & O. Vogt Brain Research Institute, Heinrich Heine University, D-40225 Düsseldorf, Germany; Institute of Computer Science, Heinrich Heine University, D-40225 Düsseldorf, Germany. Electronic address: gbezgin@research.baycrest.org.
authors: Gleb
authors: G
authors: Bezgin
authors: C. & O. Vogt Brain Research Institute, Heinrich Heine University, D-40225 Düsseldorf, Germany; Department of Diagnostic and Interventional Neuroradiology, HELIOS Medical Center Wuppertal, University Hospital Witten/Herdecke, Wuppertal, Germany.
authors: Konrad
authors: K
authors: Rybacki
authors: Department of Biophysics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6525 AJ Nijmegen, The Netherlands.
authors: A John
authors: AJ
authors: van Opstal
authors: Department of Neuroinformatics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6525 AJ Nijmegen, The Netherlands; Institute of Neuroscience and Medicine (INM-6), Research Center Jülich, Germany; Department of Biology II, Ludwig-Maximilians-Universität München, Germany.
authors: Rembrandt
authors: R
authors: Bakker
authors: Rotman Research Institute of Baycrest Centre, University of Toronto, Toronto, Ontario M6A 2E1, Canada.
authors: Kelly
authors: K
authors: Shen
authors: Rotman Research Institute of Baycrest Centre, University of Toronto, Toronto, Ontario M6A 2E1, Canada; The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
authors: Vasily A
authors: VA
authors: Vakorin
authors: Rotman Research Institute of Baycrest Centre, University of Toronto, Toronto, Ontario M6A 2E1, Canada; Department of Psychology, University of Toronto, Toronto, Ontario M5S 3G3, Canada.
authors: Anthony R
authors: AR
authors: McIntosh
authors: Department of Neuroinformatics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6525 AJ Nijmegen, The Netherlands; C. & O. Vogt Brain Research Institute, Heinrich Heine University, D-40225 Düsseldorf, Germany.
authors: Rolf
authors: R
authors: Kötter
mesh_terms: D000818:Animals; D001303:Auditory Cortex / Q000166:cytology* / Q000502:physiology*; D001369:Axons / Q000502:physiology*; D007802:Language; D008251:Macaca; D008959:Models, Neurological; D010465:Perception / Q000502:physiology; D017397:Prefrontal Cortex / Q000166:cytology* / Q000502:physiology*; D025341:Principal Component Analysis; D014793:Visual Cortex / Q000166:cytology / Q000502:physiology
keywords: Auditory cortex; Brain connectivity; Graph drawing; Parallel cortical pathways; Prefrontal cortex; Primate brain; Principal component analysis; Processing streams; Sensory system; Structure–function relationships