title: DNA hydrogel by multicomponent assembly for encapsulation and killing of cells.
abstract: In this work, a new multifunctional assembled hydrogel was prepared by incorporating gadolinium ions (Gd(3+)) with salmon-sperm DNA and polythiophene derivative (PT-COOH) through chelation interactions. Efficient energy transfer from PT-COOH to Gd(3+) ions takes place followed by sensitization of oxygen molecule to generate reactive oxygen species (ROS) under light irradiation. Cancer cells can be encapsulated into the hydrogel in situ as the formation of hydrogel followed by killing by the ROS. Integration of imaging modality with therapeutic function within a single assembled hydrogel is therefore anticipated to be a new and challenging design element for new hydrogel materials.
authors: Beijing National Laboratory for Molecular Science, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences , Beijing, 100190, P. R. China.
authors: Rong
authors: R
authors: Hu
authors: Huanxiang
authors: H
authors: Yuan
authors: Bing
authors: B
authors: Wang
authors: Libing
authors: L
authors: Liu
authors: Fengting
authors: F
authors: Lv
authors: Shu
authors: S
authors: Wang
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D002412:Cations; D002614:Chelating Agents / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D005682:Gadolinium / Q000737:chemistry; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry*; D019169:Jurkat Cells; D008855:Microscopy, Electron, Scanning; D009369:Neoplasms / Q000628:therapy*; D010100:Oxygen / Q000737:chemistry; D017382:Reactive Oxygen Species / Q000737:chemistry; D012474:Salmon; D013876:Thiophenes / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D002412:Cations; D002614:Chelating Agents; D003432:Cross-Linking Reagents; D020100:Hydrogels; D017382:Reactive Oxygen Species; D013876:Thiophenes; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D004247:DNA; D005682:Gadolinium; D010100:Oxygen