title: Comparison of Postprandial Responses to a High-Fat Meal in Hypertriglyceridemic Men and Women before and after Treatment with Fenofibrate in the Genetics and Lipid Lowering Drugs and Diet Network (GOLDN) Study.
abstract: BACKGROUND
  The fenofibrate effect on the subclass size distribution of lipoproteins before and after a high-fat challenge is not well studied.
  
  
  OBJECTIVE
  To characterize the baseline and post-prandial response (PPL) to a high-fat challenge following fenofibrate therapy, on changes in LDL, HDL, and VLDL particle subclasses, number, and size in 271 hypertriglyceridemic participants.
  
  
  METHODS
  Participants from the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study who conducted PPL studies both before and after three weeks of fenofibrate (160 mg/d) treatment were analyzed. Particle size distributions were determined using nuclear magnetic resonance imaging, and lipid determinations were measured at fasting (0 hr), 3.5 hours, and 6 hours after ingestion of a standardized high-fat meal. Analyses were stratified by gender. Changes in particle subclass distributions were assessed using repeated measures analysis of variance adjusted for pedigree.
  
  
  RESULTS
  Before PPL, fenofibrate in men (adjusted for age, field center, smoking status, diabetes, and weight circumference) lowered fasting and postprandial VLDL primarily due to reductions in postprandial levels of large and medium VLDL particles (9 SE +/-0.7 to 4 +/-0.4 and 78 / -4 to 36 / -3 nmol/L bothP< .0001, resp.). Fenofibrate also reduced fasting and postprandial total LDL particles, primarily a result of reduced small LDL particles (1497 = / - 37 to 1088 = / - 36 nmol/L,P< .0001). Directional changes were similar in men and women but the magnitude of change was different for some parameters.
  
  
  CONCLUSIONS
  Fenofibrate treatment resulted in a lower triglyceride excursion following a high-fat meal. This investigation provides new knowledge of the magnitude and time course of fenofibrate induced attenuation of Lipoprotein subclass size distribution following a postprandial lipid challenge.
authors: Department of Medicine, Division of Preventive Medicine, University of Alabama at Birmingham, AL 35294-1150, USA.
authors: Stephen P
authors: SP
authors: Glasser
authors: Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, AL 35294-1150, USA.
authors: Mary K
authors: MK
authors: Wojczynski
authors: Department of Medicine, Division of Preventive Medicine, University of Alabama at Birmingham, AL 35294-1150, USA.
authors: A I
authors: AI
authors: Oberman
authors: Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, AL 35294-1150, USA.
authors: Edmond K
authors: EK
authors: Kabagambe
authors: Department of Laboratory Medicine and Pathology, University of Minnesota, MN 55455-0213, USA.
authors: Michael Y
authors: MY
authors: Tsai
authors: Lipid Metabolism Laboratory, Tufts University, MA 02155, USA.
authors: Jose M
authors: JM
authors: Ordovas
authors: Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, MN 55455-0213, USA.
authors: Robert J
authors: RJ
authors: Straka
authors: Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, AL 35294-1150, USA.
authors: Donna K
authors: DK
authors: Arnett