title: Design and formulation of nanoemulsions using 2-(poly(hexafluoropropylene oxide)) perfluoropropyl benzene in combination with linear perfluoro(polyethylene glycol dimethyl ether).
abstract: This is the first report where PFPAE aromatic conjugates and perfluoro(polyethylene glycol dimethyl ether) are combined and formulated as nanoemulsions with droplet size below 100 nm. A perfluoropolyalkylether (PFPAE) aromatic conjugate, 2-(poly(hexafluoropropylene oxide)) perfluoropropyl benzene, was used as fluorophilic-hydrophilic diblock (FLD) aimed at stabilizing perfluoro(polyethylene glycol dimethyl ether) nanoemulsions. Its effects on colloidal behaviors in triphasic (organic/fluorous/aqueous) nanoemulsions were studied. The addition of FLD construct to fluorous phase led to decrease in PFPAE nanoemulsion droplet size to as low as 85 nm. Prepared nanoemulsions showed high colloidal stability. Our results suggest that these materials represent viable novel approach to fluorous colloid systems design with potential for biomedical and synthetic applications.
authors: Department of Chemistry, Saint Francis University, Loretto, PA, 15940, USA.
authors: Gregory A
authors: GA
authors: Mountain
authors: Department of Chemistry, Trinity Western University, Langley, BC, Canada V2Y 1Y1.
authors: Benson J
authors: BJ
authors: Jelier
authors: Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA, 15282, USA.
authors: Christina
authors: C
authors: Bagia
authors: Department of Chemistry, Trinity Western University, Langley, BC, Canada V2Y 1Y1 ; Department of Chemistry, Simon Fraser University, Burnaby, BC, Canada V5A 1S6.
authors: Chadron M
authors: CM
authors: Friesen
authors: Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA, 15282, USA.
authors: Jelena M
authors: JM
authors: Janjic
keywords: PFPAEs; PFPEs; fluorous; microfluidization; nanoemulsions; perfluoro(polyethylene glycol dimethyl ether)