title: Clinical experiences of bixalomer usage at our hospital.
abstract: In 2012, bixalomer was launched as new non-calcium (Ca) containing phosphorus (P) binder, increasing the choices available for the treatment of hyperphosphatemia. In this study, among the maintenance dialysis patients at our hospital, we newly administered bixalomer to 21 patients who were not receiving any P binders, and switched to bixalomer for 13 patients who had been receiving sevelamer hydrochloride and 23 patients who had been receiving lanthanum carbonate. The initial dosage of bixalomer was set as 1500 mg/day for new administration patients and dosage equivalent to that of the previously-used P binder for patients who were switched to bixalomer. The dosage of bixalomer was increased if the effects were insufficient. The serum P, Ca and intact parathyroid hormone concentrations as well as serum pH, HCO3 concentration and base excess were evaluated prior to administering bixalomer, 3 months and 6 months after administering bixalomer. For the group who were newly administered bixalomer, significant reductions in serum P concentrations were seen (P<0.01) and no significant changes were seen in clinical test items that serve as indices for acidosis. For the group who were switched from sevelamer hydrochloride to bixalomer, significant reductions in serum P concentrations were seen (P<0.01) together with significant improvements in acidosis (P<0.01). For the group who were switched from lanthanum carbonate to bixalomer, by increasing the dosage of bixalomer to approximately three times the dosage of lanthanum carbonate, it was possible to maintain post-switch serum P concentrations at almost the same levels as before the switch. Furthermore, there were minor, yet significant improvements in acidosis (P<0.01). From these results, it was shown that bixalomer can be useful treatment alternative in dialysis patients for whom it is necessary to change the P binder due to insufficient management of serum P concentrations or development of acidosis.
authors: Kidney Disease Center, Ohno Memorial Hospital, Osaka, Japan.
authors: Hideaki
authors: H
authors: Shima
authors: Ryojiro
authors: R
authors: Makino
authors: Kenichiro
authors: K
authors: Hata
authors: Akihiko
authors: A
authors: Ban
authors: Kiyoaki
authors: K
authors: Funao
authors: Syouzou
authors: S
authors: Sugita
authors: Yutaka
authors: Y
authors: Furumitsu
authors: Keisuke
authors: K
authors: Inoue
authors: Mitsuru
authors: M
authors: Yoshimoto
authors: Mikio
authors: M
authors: Okamura
mesh_terms: D000368:Aged; D002118:Calcium / Q000097:blood; D002614:Chelating Agents / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D054559:Hyperphosphatemia / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D007564:Japan; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D010758:Phosphorus / Q000097:blood; D011073:Polyamines / Q000097:blood* / Q000627:therapeutic use*; D011446:Prospective Studies; D006435:Renal Dialysis / Q000009:adverse effects*; D000069603:Sevelamer
chemical_list: D002614:Chelating Agents; D010281:Parathyroid Hormone; D011073:Polyamines; D010758:Phosphorus; C000589735:bixalomer; D000069603:Sevelamer; D002118:Calcium
keywords: Acidosis; Bixalomer; Lanthanum carbonate; Serum phosphorus concentration; Sevelamer hydrochloride