title: Pallidal deep brain stimulation in the treatment of Meige syndrome.
abstract: BACKGROUND
  Meige syndrome (MS) is characterized by blepharospasm, facial, oromandibular, and often cervical dystonia. The medical treatment of this condition is challenging and unsuccessful over long time. Recent case reports and small clinical series showed that bilateral deep brain stimulation (DBS) of globus pallidus pars interna (GPi) improves dystonic features of MS validated by Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS).
  
  
  METHODS
  We report on our experience in using bilateral GPi DBS in 3 cases of MS. We present short-term (3 months) follow-up as well long-term (from 8 months to 36 months) results. Preoperative and postoperative BFMDRS assessments were performed on each patient. The postoperative BFMDRS scores was done when both stimulators were switched on and compared to baseline scores.
  
  
  RESULTS
  Bilateral GPi DBS reduced the BFMDRS total movement score by 66% at short-term follow-up, and by 75% at long-term follow-up when compared to baseline scores. The BFMDRS total disability score was reduced by 34% at short-term follow-up, and by 47% at long-term follow-up when compared to baseline scores.
  
  
  CONCLUSIONS
  Our results showed that bilateral GPi DBS in MS is effective and safe, if conservative treatment options failed. The benefit is not only observed at short-term 3 months period but is maintained at long-term follow-up ranging from 8 to 36 months.
authors: Department of Neurosurgery, Postgraduate Medical Center, Warsaw, Poland. Electronic address: mrsob@op.pl.
authors: Michał
authors: M
authors: Sobstyl
authors: Department of Neurosurgery, Postgraduate Medical Center, Warsaw, Poland.
authors: Mirosław
authors: M
authors: Ząbek
authors: Department of Neurosurgery, Bródno Mazovia Hospital, Warsaw, Poland.
authors: Zbigniew
authors: Z
authors: Mossakowski
authors: Department of Neurosurgery, Bródno Mazovia Hospital, Warsaw, Poland.
authors: Artur
authors: A
authors: Zaczyński
mesh_terms: D000328:Adult; D046690:Deep Brain Stimulation / Q000379:methods*; D004185:Disability Evaluation; D005260:Female; D005500:Follow-Up Studies; D005917:Globus Pallidus / Q000502:physiology*; D006801:Humans; D008209:Lymphedema / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D013997:Time Factors
keywords: Deep brain stimulation; Meige syndrome; Pallidal stimulation