title: Adrenocortical carcinoma: the management of metastatic disease.
abstract: Adrenocortical cancer is a rare malignancy. While surgery is the cornerstone of the management of localized disease, metastatic disease is hard to treat. Cytotoxic chemotherapy and mitotane have been utilized with a variable degree of benefit and few long-term responses. A growing understanding of the molecular pathogenesis of this malignancy as well as multidisciplinary and multi-institutional collaborative efforts will result in better defined targets and subsequently, effective novel therapies.
authors: Dana-Farber Cancer Institute, Boston, MA, United States. Electronic address: Andre_Fay@dfci.harvard.edu.
authors: André P
authors: AP
authors: Fay
authors: Dana-Farber Cancer Institute, Boston, MA, United States; Brigham and Women's Hospital, Boston, MA, United States; Harvard Medical School, Boston, MA, United States.
authors: Aymen
authors: A
authors: Elfiky
authors: Joslin Diabetes Center, Boston, MA, United States.
authors: Gabriela H
authors: GH
authors: Teló
authors: Dana-Farber Cancer Institute, Boston, MA, United States.
authors: Rana R
authors: RR
authors: McKay
authors: Dana-Farber Cancer Institute, Boston, MA, United States.
authors: Marina
authors: M
authors: Kaymakcalan
authors: Dana-Farber Cancer Institute, Boston, MA, United States; Brigham and Women's Hospital, Boston, MA, United States; Harvard Medical School, Boston, MA, United States.
authors: Paul L
authors: PL
authors: Nguyen
authors: Brigham and Women's Hospital, Boston, MA, United States; Harvard Medical School, Boston, MA, United States.
authors: Anand
authors: A
authors: Vaidya
authors: Dana-Farber Cancer Institute, Boston, MA, United States; Brigham and Women's Hospital, Boston, MA, United States; Harvard Medical School, Boston, MA, United States.
authors: Daniel T
authors: DT
authors: Ruan
authors: Dana-Farber Cancer Institute, Boston, MA, United States; Brigham and Women's Hospital, Boston, MA, United States; Harvard Medical School, Boston, MA, United States.
authors: Joaquim
authors: J
authors: Bellmunt
authors: Dana-Farber Cancer Institute, Boston, MA, United States; Brigham and Women's Hospital, Boston, MA, United States; Harvard Medical School, Boston, MA, United States. Electronic address: toni_choueiri@dfci.harvard.edu.
authors: Toni K
authors: TK
authors: Choueiri
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000188:drug therapy* / Q000473:pathology; D018268:Adrenocortical Carcinoma / Q000188:drug therapy* / Q000556:secondary; D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D019468:Disease Management; D006801:Humans
chemical_list: D018931:Antineoplastic Agents, Hormonal
keywords: Adrenocortical carcinoma; Metastatic disease; Targeted therapies; Therapeutics