title: Estimation of the lipophilicity of new anticancer and immunosuppressive 1,8-diazaphenothiazine derivatives.
abstract: The lipophilicity of anticancer and immunosuppressant active 1,8-diazaphenothiazine derivatives ( 1: - 16: ) has been investigated. Their lipophilicity (RM0 and log PTLC) was determined by reversed-phase thin-layer chromatography with mixtures of acetone and TRIS buffer as mobile phases. The parameter RM0 and specific hydrophobic surface area b were significantly intercorrelated showing congeneric classes of dipyridothiazines. The parameter RM0 was discussed in the terms of the structure-lipophilicity relationships and transformed into parameter log PTLC by use of the calibration curve. The lipophilicity was correlated with molecular and biomolecular descriptors (human intestinal absorption, blood-brain barrier, plasma protein binding, MDCK) and in vitro tumor necrosis factor alpha inhibition and antiproliferative activity.
authors: Department of Organic Chemistry, The Medical University of Silesia, Jagiellońska 4, Sosnowiec 41-200, Poland bmlodawska@sum.edu.pl.
authors: Beata
authors: B
authors: Morak-Młodawska
authors: Department of Organic Chemistry, The Medical University of Silesia, Jagiellońska 4, Sosnowiec 41-200, Poland.
authors: Krystian
authors: K
authors: Pluta
authors: Department of Organic Chemistry, The Medical University of Silesia, Jagiellońska 4, Sosnowiec 41-200, Poland.
authors: Małgorzata
authors: M
authors: Jeleń
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D056148:Chromatography, Reverse-Phase; D057927:Hydrophobic and Hydrophilic Interactions; D007166:Immunosuppressive Agents / Q000737:chemistry*; D010640:Phenothiazines / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents; D010640:Phenothiazines