title: Lycopene intake facilitates the increase of bone mineral density in growing female rats.
abstract: Intake of the antioxidant lycopene has been reported to decrease oxidative stress and have beneficial effects on bone health. However, few in vivo studies have addressed these beneficial effects in growing female rodents or young women. The aim of this study was to investigate the effect of lycopene intake on bone metabolism through circulating oxidative stress in growing female rats. Six-week-old Sprague-Dawley female rats were randomly divided into 3 groups according to the lycopene content in their diet: 0, 50, and 100 ppm. The bone mineral density (BMD) of the lumbar spine and the tibial proximal metaphysis increased with lycopene content in a dose-dependent manner; the BMD in 100 ppm group was significantly higher than in the 0 ppm group. The urine deoxypyridinoline concentrations were significantly lower in the 50 and 100 ppm groups than in the 0 ppm group, and the serum bone-type alkaline phosphatase activity was significantly higher in 100 ppm group than in the 0 ppm group. No difference in systemic oxidative stress level was observed; however, the oxidative stress level inversely correlated with the tibial BMD. Our findings suggested that lycopene intake facilitates bone formation and inhibits bone resorption, leading to an increase of BMD in growing female rats.
authors: Department of Physical Education, Health and Sport Sciences, Graduate School of Comprehensive Human Science, University of Tsukuba.
authors: Yuki
authors: Y
authors: Iimura
authors: Umon
authors: U
authors: Agata
authors: Satoko
authors: S
authors: Takeda
authors: Yuki
authors: Y
authors: Kobayashi
authors: Shigeki
authors: S
authors: Yoshida
authors: Ikuko
authors: I
authors: Ezawa
authors: Naomi
authors: N
authors: Omi
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000596:Amino Acids / Q000652:urine; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D015519:Bone Density / Q000187:drug effects*; D050071:Bone Density Conservation Agents / Q000494:pharmacology; D001862:Bone Resorption / Q000517:prevention & control; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism; D002338:Carotenoids / Q000494:pharmacology*; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D005260:Female; D008159:Lumbar Vertebrae / Q000187:drug effects / Q000378:metabolism; D000077276:Lycopene; D018551:Solanum lycopersicum / Q000737:chemistry*; D010012:Osteogenesis / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D011897:Random Allocation; D017207:Rats, Sprague-Dawley; D013977:Tibia / Q000187:drug effects / Q000378:metabolism
chemical_list: D000596:Amino Acids; D000975:Antioxidants; D050071:Bone Density Conservation Agents; D010936:Plant Extracts; D002338:Carotenoids; C036020:deoxypyridinoline; D000469:Alkaline Phosphatase; D000077276:Lycopene