title: Toxic and antifeedant activities of prenylated flavonoids isolated from Tephrosia apollinea L. against three major coleopteran pests of stored grains with reference to their structure-activity relationship.
abstract: Four prenylated flavonoids, isoglabratephrin, (+)-glabratephrin, tephroapollin-F and lanceolatin-A, were isolated from Tephrosia apollinea L. and tested against three stored grain insects. Using the filter paper bioassay, compounds showed adulticidal activity against Sitophilus oryzae (L), Rhyzopertha dominica (F) and Tribolium castaneum (Herbst) at concentrations of 0.875, 1.75 and 3.5 mg mL(- 1). At 3.5 mg mL(- 1), tephroapollin-F was the most toxic (78.6%, 64.6% and 60.7% mortality was recorded after 10 days exposure of S. oryzae, R. dominica and T. castaneum, respectively). The F1 progeny production of insects was affected after parental exposure to flavonoids, where S. oryzae was the most susceptible. A nutritional bioassay, employing a flour disc and test concentrations of 0.65, 1.3 and 2.6 mg g(- 1), revealed a significant reduction in the relative growth rate, relative consumption rate and efficiency of conversion of ingested food by all insects. The structure-activity relationship among the tested flavonoids was discussed.
authors: a Zoology Department , Faculty of Science, Kafrelsheikh University , 33516 Kafr El Sheikh , Egypt.
authors: Gomah E
authors: GE
authors: Nenaah
mesh_terms: D000818:Animals; D001517:Coleoptera / Q000187:drug effects; D004534:Egypt; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005433:Flour / Q000382:microbiology; D007313:Insecta / Q000187:drug effects; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D031304:Tephrosia / Q000737:chemistry*; D014231:Tribolium / Q000187:drug effects; D048889:Weevils / Q000187:drug effects
chemical_list: D005419:Flavonoids; D007306:Insecticides; C532409:glabratephrin; C546075:isoglabratephrin; C000595290:lanceolatin A; C000595289:tephroapollin F
keywords: Tephrosia apollinea; antifeedant activity; insecticidal activity; prenylated flavonoids; stored grain insects; structure–activity relationship