title: Matrix-mini-tablets of lornoxicam for targeting early morning peak symptoms of rheumatoid arthritis.
abstract: OBJECTIVE
  The aim of present research was to develop matrix-mini-tablets of lornoxicam filled in capsule for targeting early morning peak symptoms of rheumatoid arthritis.
  
  
  METHODS
  Matrix-mini-tablets of lornoxicam were prepared by direct compression method using microsomal enzyme dependent and pH-sensitive polymers which were further filled into an empty HPMC capsule. To assess the compatibility, FT-IR and DSC studies for pure drug, polymers and their physical mixture were performed. The formulated batches were subjected to physicochemical studies, estimation of drug content, in vitro drug release, drug release kinetics, and stability studies.
  
  
  RESULTS
  When FTIR and DSC studies were performed it was found that there was no interaction between lornoxicam and polymers which used. All the physicochemical properties of prepared matrix-mini-tablets were found to be in normal limits. The percentage of drug content was found to be 99.60±0.07%. Our optimized matrix mini-tablets-filled-capsule formulation F30 released lornoxicam after a lag time of 5.02±0.92 hr, 95.48±0.65 % at the end of 8 hr and 99.90±0.83 % at the end of 12 hr. Stability was also found for this formulation as per the guidelines of International Conference on Harmonisation of Technical Requirements of Pharmaceuticals for Human Use.
  
  
  CONCLUSIONS
  A novel colon targeted delivery system of lornoxicam was successfully developed by filling matrix-mini-tablets into an empty HPMC capsule shell for targeting early morning peak symptoms of rheumatoid arthritis.
authors: Department of Pharmaceutics, Bhaskar Pharmacy College (JB Group of Educational Institutions), Yenkapally (V), Moinabad (M), R.R.District, Hyderabad-500075, Andhra Pradesh, India.
authors: Abdul Hadi
authors: AH
authors: Mohd
authors: Jyothishmathi Institute of Pharmaceutical Science, Thimmapur, Karimnagar -505481, Andhra Pradesh, India.
authors: Nidagurthi Guggilla
authors: NG
authors: Raghavendra Rao
authors: Bhaskar Pharmacy College (JB Group of Educational Institutions), Yenkapally (V), Moinabad (M), R.R.District, Hyderabad-500075, Andhra Pradesh, India.
authors: Srinivasa Rao
authors: SR
authors: Avanapu
keywords: Lornoxicam; Matrix-mini-tablets-filled-capsule system; Microsomal enzyme dependent polymers; Rheumatoid arthritis; pH-sensitive polymers