title: Allosteric binding of capsaicin by a bis(β-cyclodextrin)-2,2'-bipyridine receptor.
abstract: A new β-cyclodextrin-based receptor that showed allosteric binding behavior towards capsaicin in aqueous solution was prepared. By NMR titration and nonlinear regression, we obtained binding constants, which increased more than fivefold when an effector (Zn(2+)) was bound to a central 2,2'-bipyridine that acts as the allosteric center.
authors: Kekulé-Institut für Organische Chemie und Biochemie, Rheinische Friedrich-Wilhelms-Universität Bonn, Gerhard-Domagk-Strasse 1, 53121 Bonn (Germany), Fax: (+49) 228-73-9608.
authors: Christopher
authors: C
authors: Kremer
authors: Arne
authors: A
authors: Lützen
mesh_terms: D015082:2,2'-Dipyridyl / Q000737:chemistry*; D000495:Allosteric Site; D000982:Antipruritics / Q000737:chemistry*; D001665:Binding Sites; D002211:Capsaicin / Q000737:chemistry*; D008958:Models, Molecular; D015032:Zinc / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000982:Antipruritics; D047392:beta-Cyclodextrins; D015082:2,2'-Dipyridyl; D015032:Zinc; C031215:betadex; D002211:Capsaicin
keywords: allosteric regulations; bipyridines; capsaicin; cyclodextrins; host-guest systems