title: Synthesis of tertiary propargylamines via a rationally designed multicomponent reaction of primary amines, formaldehyde, arylboronic acids and alkynes.
abstract: A novel approach for the synthesis of tertiary propargylamines is achieved through a Cu(OAc)2-catalyzed multicomponent reaction of primary amines, formaldehyde, arylboronic acids and alkynes, where a combination of PBM and A(3)-coupling reactions is involved in this new multicomponent reaction.
authors: Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, P. R. China. ghsong@ecust.edu.cn.
authors: Jiayi
authors: J
authors: Wang
authors: Qiaoying
authors: Q
authors: Shen
authors: Pinzhen
authors: P
authors: Li
authors: Yanqing
authors: Y
authors: Peng
authors: Gonghua
authors: G
authors: Song
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D005557:Formaldehyde / Q000737:chemistry*; D010293:Pargyline / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D011437:Propylamines / Q000138:chemical synthesis* / Q000737:chemistry; D012997:Solvents / Q000737:chemistry
chemical_list: D000480:Alkynes; D000588:Amines; D001897:Boronic Acids; D011437:Propylamines; D012997:Solvents; D005557:Formaldehyde; C009054:propargylamine; D010293:Pargyline