title: Double barrier as an effective method for slower delivery rate of ibuprofen.
abstract: Ibuprofen (IBU) was chosen as a model drug to investigate the drug delivery rate. Mesoporous MCM-41 has been charged with ibuprofen (MCM-41_IBU). Calcium alginate was applied to encapsulate free drug and the mesoporous material. The system with double barrier demonstrated a slower release of IBU than free ibuprofen-loaded alginate beads and MCM-41_IBU. The IBU release from alginate matrix can be controlled by adjusting the free IBU/MCM-41_IBU ratio.
authors: Faculty of Chemistry, Adam Mickiewicz University in Poznań, Umultowska 89B, Poznań 61-614, Poland. Electronic address: asiaw@amu.edu.pl.
authors: Joanna
authors: J
authors: Kurczewska
authors: Faculty of Chemistry, Adam Mickiewicz University in Poznań, Umultowska 89B, Poznań 61-614, Poland.
authors: Dawid
authors: D
authors: Lewandowski
authors: Faculty of Chemistry, Adam Mickiewicz University in Poznań, Umultowska 89B, Poznań 61-614, Poland.
authors: Anna
authors: A
authors: Olejnik
authors: Faculty of Chemistry, Adam Mickiewicz University in Poznań, Umultowska 89B, Poznań 61-614, Poland.
authors: Grzegorz
authors: G
authors: Schroeder
authors: Faculty of Chemistry, Adam Mickiewicz University in Poznań, Umultowska 89B, Poznań 61-614, Poland.
authors: Izabela
authors: I
authors: Nowak
mesh_terms: D000464:Alginates / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D016503:Drug Delivery Systems; D065546:Drug Liberation; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry; D007052:Ibuprofen / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D000464:Alginates; D000894:Anti-Inflammatory Agents, Non-Steroidal; D006603:Hexuronic Acids; D020100:Hydrogels; C509968:MCM-41; D012822:Silicon Dioxide; D020723:Glucuronic Acid; D007052:Ibuprofen
keywords: Alginate; Controlled release; Ibuprofen; MCM-41