title: DNA replication: damage tolerance at the assembly line.
abstract: Damage tolerance mechanisms ensure resumption of DNA synthesis at damage-replisome encounters. Replication fork reversal (RFR) is one such widely recognized mechanism that acts on replisomes where lagging strand synthesis continues upon leading strand synthesis block. The possibility to form such a structure is highly counter to our current understanding of the replisome dynamics of single replisomes. Here, I suggest a model that takes coupled bidirectional replisome organization into account to solve this apparent contradiction.
authors: Department of Biochemistry and Molecular Biology, University of Szeged, Faculty of Science and Informatics, H-6726 Szeged, Hungary. Electronic address: blastyak@brc.hu.
authors: András
authors: A
authors: Blastyák
mesh_terms: D000818:Animals; D004249:DNA Damage / Q000502:physiology*; D004261:DNA Replication; D004268:DNA-Binding Proteins / Q000378:metabolism; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D006801:Humans
chemical_list: D004268:DNA-Binding Proteins; D004259:DNA-Directed DNA Polymerase
keywords: bidirectional replication; coupled replisomes; damage tolerance; replication factory; replication fork reversal