title: Comparison of the chronic effects of ribavirin and caffeic acid phenethyl ester (CAPE) on pancreatic damage and hepatotoxicity.
abstract: This study was aimed to comparison of the effects of the chronic use of the Ribavirin and caffeic acid phenethyl ester (CAPE) on the pancreatic damage and hepatotoxicity in rats.
  
  
  METHODS
  The rats were given orally 30 mg/kg/day doses of Ribavirin for 30 days, and intraperitoneally 10 μmol/kg doses of CAPE. The 37 rats were divided into 4 groups: (I) Control (n=7), (II) Ribavirin (R) (n=10), (III) CAPE (n=10), and (IV) R+CAPE (n=10).
  
  
  RESULTS
  Ribavirin and CAPE yielded similar results in terms of Serum, total antioxidant status (TAS), total oxidant status (TOS), amylase, lipase, and insulin compared to the control group. However, while Ribavirin provided similar results with the control group in terms of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) enzymes, the CAPE group had elevated AST and ALT levels compared to the control group. Histopathologic evaluations revealed that CAPE or Ribavirin had no degenerative effects on both the pancreas and liver tissues. In this way, the biochemical results were confirmed by the histopathologic results.
  
  
  CONCLUSIONS
  It can be concluded that Ribavirin does not lead to any pancreatic damage and hepatotoxicity, and has more beneficial effects than CAPE on especially liver tissue.
authors: Department of Biochemistry, School of Medicine, Mustafa Kemal University Hatay, Turkey.
authors: Sedat
authors: S
authors: Motor
authors: Department of Pharmacology, School of Medicine, Mustafa Kemal University Hatay, Turkey.
authors: Harun
authors: H
authors: Alp
authors: Department of Medical Pathology, School of Medicine, Medeniyet University Istanbul, Turkey.
authors: Serkan
authors: S
authors: Senol
authors: Department of Pharmacology, School of Medicine, Mustafa Kemal University Hatay, Turkey.
authors: Neslihan
authors: N
authors: Pınar
authors: Department of Infectious Diseases and Clinical Microbiology, School of Medicine, Mustafa Kemal University Hatay, Turkey.
authors: Vicdan Köksaldı
authors: VK
authors: Motor
authors: Department of Biochemistry, School of Medicine, Dicle University Diyarbakir, Turkey.
authors: Ibrahim
authors: I
authors: Kaplan
authors: Department of Biochemistry, Hatay Maternity and Pediatric Hospital Hatay, Turkey.
authors: Ayşe
authors: A
authors: Alp
authors: Department of Endocrinology and Metabolism, School of Medicine, Mustafa Kemal University Hatay, Turkey.
authors: Cumali
authors: C
authors: Gökçe
keywords: CAPE; hepatotoxicity; insulin; oxidative stress; pancreatic damage; ribavirin