title: Adult T-cell leukemia/lymphoma.
abstract: Adult T-cell leukemia/lymphoma is a rare malignancy associated with the human retrovirus human T-cell lymphotropic virus type 1. It is characterized by the proliferation of highly pleomorphic lymphocytes. Involvement of peripheral blood, bone marrow, lymph nodes, spleen, and extranodal sites such as skin, liver, gastrointestinal tract, and central nervous system can occur. There are four distinct clinical variants, and the prognosis and clinical course range from highly aggressive to a more protracted course depending on the subtype. We describe a man with de novo adult T-cell leukemia/lymphoma and discuss the unique clinical, morphologic, immunophenotypic, and molecular features of this entity.
authors: Department of Pathology, Section of Hematopathology (Graham, Krause), and the Department of Hematology/Oncology (Burch), Baylor University Medical Center at Dallas and Baylor Charles A. Sammons Cancer Center, Dallas, Texas.
authors: Robbie L
authors: RL
authors: Graham
authors: Department of Pathology, Section of Hematopathology (Graham, Krause), and the Department of Hematology/Oncology (Burch), Baylor University Medical Center at Dallas and Baylor Charles A. Sammons Cancer Center, Dallas, Texas.
authors: Micah
authors: M
authors: Burch
authors: Department of Pathology, Section of Hematopathology (Graham, Krause), and the Department of Hematology/Oncology (Burch), Baylor University Medical Center at Dallas and Baylor Charles A. Sammons Cancer Center, Dallas, Texas.
authors: John R
authors: JR
authors: Krause