title: Unprecedent aminophysalin from Physalis angulata.
abstract: The 95% ethanol extract of the whole plant of Physalis angulata Linn. afforded one new skeletal physalin named aminophysalin A (1) and one new naturally occurring 5β-hydroxy-6a-chloro-5,6-dihydrophysalin B (2), together with five known physalins (3-7). Their structures were elucidated through MS, IR, NMR spectroscopy analyses and X-ray crystallography. Aminophysalin A (1) had an absolutely unusual structural feature in the chemistry of physalins with a nitrogen atom. Compounds 1-7 were evaluated for quinone reductase activities in hepa 1c1c7 cells. Physalin H (6) showed strong quinone reductase induction activity with IR (Induction ratio, QR induction activity) value of 3.74±0.02, using 4-bromoflavone as a positive control substance (2.17±0.01, 10 μg/mL), while compounds 1, 2, 3, 5 showed weak quinone reductase induction activity.
authors: Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, No. 103 Wenhua Road, Shenyang 110016, China.
authors: Rui-Zhi
authors: RZ
authors: Men
authors: Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, No. 103 Wenhua Road, Shenyang 110016, China.
authors: Ning
authors: N
authors: Li
authors: Institute of Marine Biology, Ocean College, Zhejiang University, Zijingang Campus, No. 866 Yuhangtang Road, Hangzhou 310058, PR China.
authors: Wan-Jing
authors: WJ
authors: Ding
authors: Institute of Marine Biology, Ocean College, Zhejiang University, Zijingang Campus, No. 866 Yuhangtang Road, Hangzhou 310058, PR China.
authors: Zhi-Juan
authors: ZJ
authors: Hu
authors: Institute of Marine Biology, Ocean College, Zhejiang University, Zijingang Campus, No. 866 Yuhangtang Road, Hangzhou 310058, PR China. Electronic address: mazj@zju.edu.cn.
authors: Zhong-Jun
authors: ZJ
authors: Ma
authors: Chinese Traditional Medicine Hospital of Zhejiang Province, No. 54 Youdian Road, Hangzhou 310006, PR China.
authors: Lin
authors: L
authors: Cheng
mesh_terms: D002460:Cell Line; D004790:Enzyme Induction / Q000187:drug effects; D000431:Ethanol / Q000737:chemistry; D006801:Humans; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000096:biosynthesis; D032321:Physalis / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D013256:Steroids; D000431:Ethanol; D016660:NAD(P)H Dehydrogenase (Quinone)
keywords: Aminophysalin; Physalin; Physalis angulata Linn; QR induction activity