title: 2-Phenoxychromones and prenylflavonoids from Epimedium koreanum and their inhibitory effects on LPS-induced nitric oxide and interleukin-1β production.
abstract: Two new 2-phenoxychromones 1 and 2 and two prenylflavonoids 3 and 4 along with 12 known compounds (5-16) were isolated from the CH2Cl2-soluble fraction of a methanol extract of Epimedium koreanum. Compounds 1, 4, 6, 7, 9, 10, 12, and 15 exhibit inhibitory effects on nitric oxide production with IC50 values ranging from 16.8 to 49.3 μM. Compounds 1, 4, 7, and 12 also showed inhibitory effects on interleukin-1β production with IC50 values ranging from 8.6 to 38.9 μM in RAW 264.7 macrophages.
authors: College of Pharmacy, Chungbuk National University , Cheongju 361-763, Korea.
authors: Qinghao
authors: Q
authors: Jin
authors: Chul
authors: C
authors: Lee
authors: Jin Woo
authors: JW
authors: Lee
authors: Eung Tae
authors: ET
authors: Yeon
authors: Dongho
authors: D
authors: Lee
authors: Sang Bae
authors: SB
authors: Han
authors: Jin Tae
authors: JT
authors: Hong
authors: Youngsoo
authors: Y
authors: Kim
authors: Mi Kyeong
authors: MK
authors: Lee
authors: Bang Yeon
authors: BY
authors: Hwang
mesh_terms: D000818:Animals; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D034181:Epimedium / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D053583:Interleukin-1beta / Q000096:biosynthesis; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D002867:Chromones; D005419:Flavonoids; D053583:Interleukin-1beta; D008070:Lipopolysaccharides; D009569:Nitric Oxide; D052247:Nitric Oxide Synthase Type II