title: Acid-base assessment: when and how to apply the Henderson-Hasselbalch equation and strong ion difference theory.
abstract: The Henderson-Hasselbalch equation is probably the most famous equation in biology but is more descriptive than mechanistic. The traditional approach to acid-base assessment using the Henderson-Hasselbalch equation provides a clinically useful and accurate method when plasma protein concentrations are within the reference range. The simplified strong ion approach is a mechanistic acid-base model that can provide new insight into complicated acid-base disturbances. The simplified strong ion approach should be used to evaluate acid-base balance whenever plasma protein concentrations are abnormal.
authors: College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, IL 61802, USA. Electronic address: constabl@illinois.edu.
authors: Peter D
authors: PD
authors: Constable
mesh_terms: D000136:Acid-Base Equilibrium; D000138:Acidosis / Q000175:diagnosis / Q000378:metabolism / Q000662:veterinary*; D000471:Alkalosis / Q000175:diagnosis / Q000378:metabolism / Q000662:veterinary*; D000820:Animal Diseases / Q000175:diagnosis / Q000378:metabolism*; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000175:diagnosis / Q000378:metabolism; D003967:Diarrhea / Q000175:diagnosis / Q000378:metabolism / Q000662:veterinary; D006863:Hydrogen-Ion Concentration; D007700:Kinetics
keywords: Acidosis; Alkalosis; Anion gap; Strong ion gap; Total CO(2)