title: Dual acquisition of (18)F-FMISO and (18)F-FDOPA.
abstract: Metabolic imaging using positron emission tomography (PET) has found increasing clinical use for the management of infiltrating tumours such as glioma. However, the heterogeneous biological nature of tumours and intrinsic treatment resistance in some regions means that knowledge of multiple biological factors is needed for effective treatment planning. For example, the use of (18)F-FDOPA to identify infiltrative tumour and (18)F-FMISO for localizing hypoxic regions. Performing multiple PET acquisitions is impractical in many clinical settings, but previous studies suggest multiplexed PET imaging could be viable. The fidelity of the two signals is affected by the injection interval, scan timing and injected dose. The contribution of this work is to propose a framework to explicitly trade-off signal fidelity with logistical constraints when designing the imaging protocol. The particular case of estimating (18)F-FMISO from a single frame prior to injection of (18)F-FDOPA is considered. Theoretical experiments using simulations for typical biological scenarios in humans demonstrate that results comparable to a pair of single-tracer acquisitions can be obtained provided protocol timings are carefully selected. These results were validated using a pre-clinical data set that was synthetically multiplexed. The results indicate that the dual acquisition of (18)F-FMISO and (18)F-FDOPA could be feasible in the clinical setting. The proposed framework could also be used to design protocols for other tracers.
authors: CSIRO Preventative Health Flagship, CSIRO Computational Informatics, The Australian e-Health Research Centre, Herston QLD 4029, Australia. School of Medicine, The University of Queensland, St Lucia, Brisbane, Australia.
authors: Christopher
authors: C
authors: Bell
authors: Stephen
authors: S
authors: Rose
authors: Simon
authors: S
authors: Puttick
authors: Alex
authors: A
authors: Pagnozzi
authors: Christopher M
authors: CM
authors: Poole
authors: Yaniv
authors: Y
authors: Gal
authors: Paul
authors: P
authors: Thomas
authors: Michael
authors: M
authors: Fay
authors: Rosalind L
authors: RL
authors: Jeffree
authors: Nicholas
authors: N
authors: Dowson
mesh_terms: D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D007700:Kinetics; D008920:Misonidazole / Q000031:analogs & derivatives*; D008954:Models, Biological; D049268:Positron-Emission Tomography; D011829:Radiation Dosage
chemical_list: C031843:fluoromisonidazole; C043437:fluorodopa F 18; D004295:Dihydroxyphenylalanine; D008920:Misonidazole