title: Perturbations of lipid metabolism indexed by lipidomic biomarkers.
abstract: The lipidome of the liver and the secreted circulating lipoproteins can now be interrogated conveniently by automated mass spectrometric methods. Multivariate analysis of the liver and serum lipid composition in various animal modes or in human patients has pointed to specific molecular species markers. The perturbations of lipid metabolism can be categorized on the basis of three basic pathological mechanisms: (1) an accelerated rate of de novo lipogenesis; (2) perturbation of the peroxisome pathway of ether-lipid and very-long-chain fatty acid biosynthesis; (3) a change in the rate of interconversion of essential omega-3 and -6 polyunsaturated fatty acids. This review provides examples to illustrate the practicalities of lipidomic studies in biomedicine.
authors: INSERM U1057, Faculte de Medicine, "P. et M. Curie" 27 rue Chaligny, Paris 75012, France. antonin.lamaziere@upmc.fr.
authors: Antonin
authors: A
authors: Lamaziere
authors: INSERM U1057, Faculte de Medicine, "P. et M. Curie" 27 rue Chaligny, Paris 75012, France. claude.wolf@upmc.fr.
authors: Claude
authors: C
authors: Wolf
authors: Department of Biochemistry, King's College London, 150 Stamford Street, London SE1 9NH, UK. p.quinn@kcl.ac.uk.
authors: Peter J
authors: PJ
authors: Quinn