title: Difference gel electrophoresis DIGE.
abstract: Proteomics offers powerful technologies to assist in the discovery of targets for novel therapeutic agents, by allowing the investigation of changes in protein state between control and diseased tissue and biofluids. Difference gel electrophoresis coupled with mass spectrometry (DIGE/MS) is a technology used within proteomics that has demonstrated technical robustness and associated statistical confidence to enable successful identification of therapeutic targets.:
authors: Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, UK CB2 1QW. Electronic address:k.s.lilley@bioc.cam.ac.uk.
authors: Kathryn S
authors: KS
authors: Lilley
authors: Proteomics Laboratory, Mass Spectrometry Research Center, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-8575, USA. Electronic address:david.friedman@vanderbilt.edu.
authors: David B
authors: DB
authors: Friedman