title: Midodrine in patients with spinal cord injury and anejaculation: A double-blind randomized placebo-controlled pilot study.
abstract: OBJECTIVE
  The objective of this study is to evaluate the efficacy of midodrine in the treatment of anejaculation in men with spinal cord injury (SCI).
  
  
  METHODS
  Prospective, double-blind, randomized, placebo-controlled pilot study.
  
  
  METHODS
  Men with anejaculation associated with SCI (level of injury above T10) of more than 1 year in duration were approached. Those with no ejaculatory response to one penile vibratory stimulation (PVS) trial were assigned in a double-blind manner to one of the two following interventions once a week for a maximum of 3 weeks or until ejaculation occurred: oral administration of flexible midodrine (7.5-22.5 mg max) followed by PVS (group M), or oral administration of flexible sham-midodrine (placebo) followed by PVS (group P). Sociodemographic data, medical characteristics, and plasma desglymidodrine concentration were collected for all participants.
  
  
  METHODS
  Ejaculation success rate in each group.
  
  
  RESULTS
  Among the 78 men approached, 23 participants (level of SCI: C4-T9) were randomized. Three participants abandoned the study and 20 completed the study; 10 were assigned to group M, 10 to group P. Ejaculation was reached for one participant of group M and for two participants of group P. Autonomic dysreflexia associated to PVS occurred in three patients.
  
  
  CONCLUSIONS
  In this small sample study, treatment of anejaculation after SCI with midodrine and PVS did not result in a better rate of antegrade ejaculation in 10 men than in 10 men treated with a placebo and PVS.
authors: Bernard E
authors: BE
authors: Leduc
authors: Christine
authors: C
authors: Fournier
authors: Géraldine
authors: G
authors: Jacquemin
authors: Yves
authors: Y
authors: Lepage
authors: Bernard
authors: B
authors: Vinet
authors: Pierre-Olivier
authors: PO
authors: Hétu
authors: Miguel
authors: M
authors: Chagnon
mesh_terms: D058646:Adrenergic alpha-1 Receptor Agonists / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000328:Adult; D004542:Ejaculation / Q000187:drug effects*; D005832:Genital Diseases, Male / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008879:Midodrine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D013119:Spinal Cord Injuries / Q000150:complications* / Q000534:rehabilitation
chemical_list: D058646:Adrenergic alpha-1 Receptor Agonists; D008879:Midodrine
keywords: Anejaculation; Midodrine; Spinal cord injury