title: The unfulfilled gene and nervous system development in Drosophila.
abstract: The unfulfilled gene of Drosophila encodes a member of the NR2E subfamily of nuclear receptors. Like related members of the NR2E subfamily, UNFULFILLED is anticipated to function as a dimer, binding to DNA response elements and regulating the expression of target genes. The UNFULFILLED protein may be regulated by ligand-binding and may also be post-transcriptionally modified by sumoylation and phosphorylation. unfulfilled mutants display a range of aberrant phenotypes, problems with eclosion and post-eclosion behaviors, compromised fertility, arrhythmicity, and a lack of all adult mushroom body lobes. The locus of the fertility problem has not been determined. The behavioral arrhythmicity is due to the unfulfilled-dependent disruption of gene expression in a set of pacemaker neurons. The eclosion and the mushroom body lobe phenotypes of unfulfilled mutants are the result of developmental problems associated with failures in axon pathfinding or re-extension. Interest in genes that act downstream of unfulfilled has resulted in the identification of a growing number of unfulfilled interacting loci, providing the first glimpse into the composition of unfulfilled-dependent gene networks. This article is part of a Special Issue entitled: Nuclear receptors in animal development.
authors: Department of Biology, University of Hawaii, Honolulu, HI 96822, USA.
authors: Karen E
authors: KE
authors: Bates
authors: Department of Biology, University of Hawaii, Honolulu, HI 96822, USA.
authors: Janos
authors: J
authors: Molnar
authors: Department of Biology, University of Hawaii, Honolulu, HI 96822, USA. Electronic address: robinow@hawaii.edu.
authors: Steven
authors: S
authors: Robinow
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D030801:Animals, Genetically Modified; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology*; D004331:Drosophila melanogaster / Q000196:embryology* / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental; D053263:Gene Regulatory Networks; D008969:Molecular Sequence Data; D024521:Mushroom Bodies / Q000196:embryology; D009420:Nervous System / Q000196:embryology*; D055495:Neurogenesis / Q000235:genetics; D010641:Phenotype; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000502:physiology*
chemical_list: D029721:Drosophila Proteins; C539176:Hr51 protein, Drosophila; D018160:Receptors, Cytoplasmic and Nuclear
keywords: Clock neurons; Mushroom body; Nuclear receptor; PNR; dHR51; fax-1