title: Self-assembled nanoscale coordination polymers with trigger release properties for effective anticancer therapy.
abstract: Nanoscale coordination polymers (NCPs) are self-assembled from metal ions and organic bridging ligands, and can overcome many drawbacks of existing drug delivery systems by virtue of tunable compositions, sizes and shapes, high drug loadings, ease of surface modification and intrinsic biodegradability. Here we report the self-assembly of zinc bisphosphonate NCPs that carry 48 ± 3 wt% cisplatin prodrug and 45 ± 5 wt% oxaliplatin prodrug. In vivo pharmacokinetic studies in mice show minimal uptake of pegylated NCPs by the mononuclear phagocyte system and excellent blood circulation half-lives of 16.4 ± 2.9 and 12.0 ± 3.9 h for the NCPs carrying cisplatin and oxaliplatin, respectively. In all tumour xenograft models evaluated, including CT26 colon cancer, H460 lung cancer and AsPC-1 pancreatic cancer, pegylated NCPs show superior potency and efficacy compared with free drugs. As the first example of using NCPs as nanotherapeutics with enhanced antitumour activities, this study establishes NCPs as a promising drug delivery platform for cancer therapy.
authors: Department of Chemistry, University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA.
authors: Demin
authors: D
authors: Liu
authors: Department of Chemistry, University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA.
authors: Christopher
authors: C
authors: Poon
authors: Department of Chemistry, University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA.
authors: Kuangda
authors: K
authors: Lu
authors: Department of Chemistry, University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA.
authors: Chunbai
authors: C
authors: He
authors: Department of Chemistry, University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA.
authors: Wenbin
authors: W
authors: Lin
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002945:Cisplatin / Q000493:pharmacokinetics / Q000494:pharmacology*; D003110:Colonic Neoplasms; D004337:Drug Carriers; D006801:Humans; D008175:Lung Neoplasms; D053768:Metal Nanoparticles; D051379:Mice; D009369:Neoplasms; D009944:Organoplatinum Compounds / Q000493:pharmacokinetics / Q000494:pharmacology*; D000077150:Oxaliplatin; D010190:Pancreatic Neoplasms; D011092:Polyethylene Glycols; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D011092:Polyethylene Glycols; D002945:Cisplatin