title: New paradigms in the establishment and maintenance of gradients during directed cell migration.
abstract: Directional guidance of migrating cells is relatively well explored in the reductionist setting of cell culture experiments. Here spatial gradients of chemical cues as well as gradients of mechanical substrate characteristics prove sufficient to attract single cells as well as their collectives. How such gradients present and act in the context of an organism is far less clear. Here we review recent advances in understanding how guidance cues emerge and operate in complex physiological settings.
authors: Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
authors: Ritankar
authors: R
authors: Majumdar
authors: IST Austria (Institute of Science and Technology Austria), 3400 Klostemeuburg, Austria.
authors: Michael
authors: M
authors: Sixt
authors: Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States. Electronic address: parentc@mail.nih.gov.
authors: Carole A
authors: CA
authors: Parent
mesh_terms: D002465:Cell Movement; D004058:Diffusion; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction