title: The metabolic syndrome is associated with an increased risk of colorectal polyps independent of plasma homocysteine.
abstract: OBJECTIVE
  The links between the metabolic syndrome and homocysteine in relation to the risk of colorectal polyps are not understood. The purpose of this study was to investigate the association between the metabolic syndrome and homocysteine and further analyze the relationship between these two factors and the risk of colorectal polyps.
  
  
  METHODS
  This was a case-control study. A total of 135 participants with colorectal polyps (cases) and 110 participants without polyps (controls) were recruited.
  
  
  RESULTS
  There were 59 participants with the metabolic syndrome in the case group and 36 participants with the metabolic syndrome in the control group. The metabolic syndrome and its individual components, except for serum triglycerides, and homocysteine were associated with the risk of colorectal polyps. When the association of the metabolic syndrome and homocysteine with the risk of colorectal polyps was simultaneously considered, the association between homocysteine and the risk of colorectal polyps disappeared, but waist circumference, systolic and diastolic blood pressure, high-density lipoprotein cholesterol, and the metabolic syndrome itself were still significant risk factors for the development of colorectal polyps.
  
  
  CONCLUSIONS
  Although the metabolic syndrome and plasma homocysteine were individually related to the risk of colorectal polyps, the metabolic syndrome was a major contributing factor in relation to the risk of colorectal polyps independent of plasma homocysteine.
authors: School of Nutrition, Chung Shan Medical University, Taichung, Taiwan, ROC.
authors: Fang-Pei
authors: FP
authors: Chen
authors: Hwei-Ming
authors: HM
authors: Wang
authors: Feng-Fan
authors: FF
authors: Chiang
authors: Chun-Che
authors: CC
authors: Lin
authors: Shih-Chien
authors: SC
authors: Huang
authors: Yi-Chia
authors: YC
authors: Huang
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D015992:Body Mass Index; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications; D008875:Middle Aged; D011127:Polyps / Q000097:blood* / Q000209:etiology; D012307:Risk Factors; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006710:Homocysteine