title: Tissue microarrays for early target evaluation.
abstract: Early assessment of the probable biological importance of drug targets, the potential market size of a successful new drug, and possible treatment side effects are critical for risk management in drug development. A comprehensive molecular epidemiology analysis involving thousands of well-characterized human tissues will thus provide vital information for strategic decision-making. Tissue microarray (TMA) technology is ideally suited for such projects. The simultaneous analysis of thousands of tissues enables highly standardized, fast and affordable translational research studies of unprecedented scale.:
authors: Division of Molecular Pathology, Institute of Pathology, Basel University Hospital, Schoenbeinstrasse 40, CH-4031 Basel, Switzerland.
authors: Ronald
authors: R
authors: Simon
authors: Division of Molecular Pathology, Institute of Pathology, Basel University Hospital, Schoenbeinstrasse 40, CH-4031 Basel, Switzerland.
authors: Martina
authors: M
authors: Mirlacher
authors: Division of Molecular Pathology, Institute of Pathology, Basel University Hospital, Schoenbeinstrasse 40, CH-4031 Basel, Switzerland. Electronic address:Guido.Sauter@unibas.ch.
authors: Guido
authors: G
authors: Sauter