title: ACT2 peer-driven intervention increases enrollment into HIV/AIDS medical studies among African Americans/Blacks and Hispanics: A cluster randomized controlled trial.
abstract: African American/Black and Hispanic persons living with HIV/AIDS ("AABH-PLHA") are under-represented in HIV/AIDS medical studies (HAMS). This paper evaluates the efficacy of a social/behavioral intervention to increase rates of screening for and enrollment into HAMS in these populations. Participants (N = 540) were enrolled into a cluster randomized controlled trial of an intervention designed to overcome multi-level barriers to HAMS. Primary endpoints were rates of screening for and enrollment into therapeutic/treatment-oriented and observational studies. Intervention arm participants were 30 times more likely to be screened than controls (49.3 % vs. 3.7 %; p < .001). Half (55.5 %) of those screened were eligible for HAMS, primarily observational studies. Nine out of ten found eligible enrolled (91.7 %), almost all into observational studies (95.2 %), compared to no enrollments among controls. Achieving appropriate representation of AABH-PLHA in HAMS necessitates modification of study inclusion criteria to increase the proportion found eligible for therapeutic HAMS, in addition to social/behavioral interventions.
authors: Center for Drug Use and HIV Research, New York University College of Nursing, 726 Broadway, 10th Floor, New York, NY, 10003, USA, mg2890@nyu.edu.
authors: Marya
authors: M
authors: Gwadz
authors: Charles M
authors: CM
authors: Cleland
authors: Mindy
authors: M
authors: Belkin
authors: Amanda
authors: A
authors: Ritchie
authors: Noelle
authors: N
authors: Leonard
authors: Marion
authors: M
authors: Riedel
authors: Angela
authors: A
authors: Banfield
authors: Pablo
authors: P
authors: Colon
authors: Vanessa
authors: V
authors: Elharrar
authors: Jonathan
authors: J
authors: Kagan
authors: Donna
authors: D
authors: Mildvan
mesh_terms: D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data*; D005260:Female; D015658:HIV Infections / Q000453:epidemiology*; D006293:Health Promotion; D054625:Healthcare Disparities; D006630:Hispanic or Latino / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000706:statistics & numerical data*; D008875:Middle Aged; D054525:Minority Health; D018579:Patient Selection; D010379:Peer Group; D014481:United States / Q000453:epidemiology