title: Antibacterial Activity of Murrayaquinone A and 6-Methoxy-3,7-dimethyl-2,3-dihydro-1H-carbazole-1,4(9H)-dione.
abstract: The antibacterial activity of Murrayaquinone A (10), a naturally occurring carbazoloquinone alkaloid, and 6-methoxy-3,7-dimethyl-2,3-dihydro-1H-carbazole-1,4(9H)-dione (11), a synthetic carbazoloquinone, both obtained during the development of the synthesis of Carbazomycin G, having unique quinone moiety, was studied against Gram-positive (Bacillus subtilis and Staphylococcus aureus) and Gram-negative (Escherichia coli and Pseudomonas sp.) bacteria. Compound 10 showed antibacterial activities against both of Escherichia coli and Staphylococcus aureus whereas compound 11 indicated the activity against Staphylococcus aureus only. Both compounds 10 and 11 exhibited minimum inhibitory concentration (MIC) of 50  μ g mL(-1) against Staphylococcus aureus.
authors: Department of Biochemistry & Medical Biotechnology, School of Tropical Medicine, Kolkata 700073, India.
authors: Biswanath
authors: B
authors: Chakraborty
authors: Department of Clinical & Experimental Pharmacology, School of Tropical Medicine, Kolkata 700073, India.
authors: Suchandra
authors: S
authors: Chakraborty
authors: Department of Clinical & Experimental Pharmacology, School of Tropical Medicine, Kolkata 700073, India.
authors: Chandan
authors: C
authors: Saha