title: Atypical fibroxanthoma: new insights.
abstract: Atypical fibroxanthoma (AFX) is an ultraviolet radiation-associated dermal neoplasm. To address the clinicopathologic and molecular features of this particular neoplasm. The author conducted a literature review using PubMed searching for articles relating to AFX. AFX usually appears as a rapidly growing nodular or nodulo-ulcerative lesion. It occurs on sun-exposed skin of elderly peoples. AFX may be composed predominantly of pleomorphic, spindle, epithelioid cells, or admixture of these cells. The differential diagnosis of AFX includes pleomorphic dermal sarcoma, squamous cell carcinoma, malignant melanoma and leiomyosarcoma. Several observations favor a mesenchymal origin for AFX. These reviews address the clinicopathologic features, molecular pathology, prognosis and treatment of this neoplasm.
authors: Department of Pathology, Faculty of Medicine and Assuit University Hospitals, Assiut University, Assiut, Egypt.
authors: Mahmoud Rezk Abdelwahed
authors: MR
authors: Hussein
mesh_terms: D000368:Aged; D000818:Animals; D003937:Diagnosis, Differential; D005350:Fibroma / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D006801:Humans; D011379:Prognosis; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D013472:Sunlight / Q000009:adverse effects; D014466:Ultraviolet Rays / Q000009:adverse effects; D014973:Xanthomatosis / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy
keywords: atypical fibroxanthoma; clinicopathologic; dermal sarcoma; pathogenesis; ultraviolet light