title: Influenza immunization in hemodialyzed or kidney transplanted adolescents and young adults.
abstract: OBJECTIVE
  To clarify the immunogenicity and safety of influenza vaccine in patients with end-stage kidney disease (ESKD) on dialysis or who have received a kidney transplant.
  
  
  METHODS
  Sixty adolescents and young adults with ESKD (25 on hemodialysis and 35 kidney transplant recipients) were randomized 1:1 to receive a traditional trivalent split virion vaccine (TIIV) or a virosome-adjuvanted trivalent inactivated influenza vaccine (VATIIV). The immunogenicity and safety of the two vaccines was evaluated and compared with the findings observed in 30 healthy subjects of similar age and gender distribution who received TIIV.
  
  
  RESULTS
  The results indicate that the immune response of the patients to TIIV and VATIIV were similar. The administered vaccines were safe and well tolerated, and no advantage was found with the use of VATIIV.
  
  
  CONCLUSIONS
  Given the potential clinical relevance of influenza in patients with ESKD, these findings support the official recommendation that they should receive annual influenza vaccinations.
authors: Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
authors: Susanna
authors: S
authors: Esposito
authors: Maria Vincenza
authors: MV
authors: Mastrolia
authors: Luciana
authors: L
authors: Ghio
authors: Fabio
authors: F
authors: Paglialonga
authors: Leonardo
authors: L
authors: Terranova
authors: Alessia
authors: A
authors: Scala
authors: Alberto
authors: A
authors: Edefonti
authors: Nicola
authors: N
authors: Principi
mesh_terms: D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology; D005260:Female; D006801:Humans; D007114:Immunization / Q000009:adverse effects / Q000379:methods*; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D007251:Influenza, Human / Q000517:prevention & control*; D016030:Kidney Transplantation; D008297:Male; D011446:Prospective Studies; D006435:Renal Dialysis; D051437:Renal Insufficiency; D016037:Single-Blind Method; D022223:Vaccines, Subunit / Q000008:administration & dosage / Q000276:immunology; D022721:Vaccines, Virosome / Q000008:administration & dosage / Q000276:immunology; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines; D022223:Vaccines, Subunit; D022721:Vaccines, Virosome
keywords: chronic renal disease; hemodialysis; influenza vaccination; kidney transplantation; trivalent inactivated influenza vaccine; virosomal-adjuvanted influenza vaccine