title: Formulation of indomethacin colon targeted delivery systems using polysaccharides as carriers by applying liquisolid technique.
abstract: The present study aimed at the formulation of matrix tablets for colon-specific drug delivery (CSDD) system of indomethacin (IDM) by applying liquisolid (LS) technique. A CSDD system based on time-dependent polymethacrylates and enzyme degradable polysaccharides was established. Eudragit RL 100 (E-RL 100) was employed as time-dependent polymer, whereas bacterial degradable polysaccharides were presented as LS systems loaded with the drug. Indomethacin-loaded LS systems were prepared using different polysaccharides, namely, guar gum (GG), pectin (PEC), and chitosan (CH), as carriers separately or in mixtures of different ratios of 1:3, 1:1, and 3:1. Liquisolid systems that displayed promising results concerning drug release rate in both pH 1.2 and pH 6.8 were compressed into tablets after the addition of the calculated amount of E-RL 100 and lubrication with magnesium stearate and talc in the ratio of 1:9. It was found that E-RL 100 improved the flowability and compressibility of all LS formulations. The release data revealed that all formulations succeeded to sustain drug release over a period of 24 hours. Stability study indicated that PEC-based LS system as well as its matrix tablets was stable over the period of storage (one year) and could provide a minimum shelf life of two years.
authors: Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia ; Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.
authors: Kadria A
authors: KA
authors: Elkhodairy
authors: Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia ; Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
authors: Hanna A
authors: HA
authors: Elsaghir
authors: Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia.
authors: Amal M
authors: AM
authors: Al-Subayiel
mesh_terms: D000818:Animals; D002626:Chemistry, Pharmaceutical; D048271:Chitosan / Q000737:chemistry; D003106:Colon / Q000187:drug effects*; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D004355:Drug Stability; D005685:Galactans / Q000737:chemistry; D007213:Indomethacin / Q000008:administration & dosage* / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D008351:Mannans / Q000737:chemistry; D010368:Pectins / Q000737:chemistry; D053149:Plant Gums / Q000737:chemistry; D011134:Polysaccharides / Q000737:chemistry*; D017208:Rats, Wistar; D012212:Rheology; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013607:Tablets
chemical_list: D004337:Drug Carriers; D005685:Galactans; D008351:Mannans; D053149:Plant Gums; D011134:Polysaccharides; D013607:Tablets; D010368:Pectins; D048271:Chitosan; C007894:guar gum; D007213:Indomethacin