title: Impact of endobronchial coiling for lung volume reduction on pulmonary volume and attenuation: preinterventional and postinterventional computed tomography-quantification using separate lobe measurements.
abstract: OBJECTIVE
  The aim of this study was to objectify changes in volume and density of treated and untreated pulmonary lobes following endobronchial coiling for lung volume reduction by comparison with clinical (6-m walk test) and pulmonary function tests.
  
  
  METHODS
  Twenty-two lobes in 17 patients (8 men, 9 women) were treated by endobronchial coiling and underwent preinterventional and postinterventional computed tomography examinations (inspiratory and expiratory phase) as well as pulmonary function test measurements.
  
  
  RESULTS
  Responders (n = 14) presented a significant increase (70 ± 11 m) in the walking distance (6-m walk test) and FEV1 (forced expiratory volume in 1 second) values (61 ± 21 mL). Only in responders inspiratory volume (VolIn) of the target lobe significantly decreased (10.0% ± 16.4%; P = 0.0245), and VolIn of the nontreated ipsilateral lobe significantly increased (5.5% ± 9.1%; P = 0.0209).
  
  
  CONCLUSIONS
  Our results objectify volume reduction of the treated lobe coupled by a significant volume expansion of the ipsilateral lobe as a sole correlate for clinical improvement in responders.
authors: From the *Diagnostic and Interventional Radiology and †Department of Oncology, Hematology, Immunology, Rheumatology and Pulmonology, University Hospital Tuebingen, Tuebingen; and ‡Computed Tomography, Siemens Medical Solutions, Forchheim, Germany.
authors: Ulrich
authors: U
authors: Grosse
authors: Jörg
authors: J
authors: Hetzel
authors: Lutz
authors: L
authors: Gündel
authors: Sergios
authors: S
authors: Gatidis
authors: Roland
authors: R
authors: Syha
authors: Christoph
authors: C
authors: Schabel
authors: Fabian
authors: F
authors: Springer
authors: Marius
authors: M
authors: Horger
mesh_terms: D000368:Aged; D004646:Emphysema / Q000000981:diagnostic imaging* / Q000628:therapy*; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal / Q000295:instrumentation / Q000379:methods*; D008137:Longitudinal Studies; D008168:Lung / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D008176:Lung Volume Measurements / Q000379:methods; D008297:Male; D008875:Middle Aged; D015641:Radiography, Interventional / Q000379:methods*; D012189:Retrospective Studies; D013990:Tidal Volume; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome