title: The color and size of chili peppers (Capsicum annuum) influence Hep-G2 cell growth.
abstract: Four types of chili (Capsicum annuum) extracts, categorized according to color; green and red, and size; small and large were studied in Hep-G2 cells. Red small (RS) chili had an LC50 value of 0.378 ± 0.029 compared to green big (GB) 1.034 ± 0.061 and green small (GS) 1.070 ± 0.21 mg/mL. Red big (RB) was not cytotoxic. Capsaicin content was highest in RS and produced a greater percentage sub-G1 cells (6.47 ± 1.8%) after 24 h compared to GS (2.96 ± 1.3%) and control (1.29 ± 0.8%) cells. G2/M phase was reduced by GS compared to RS and control cells. RS at the LC50 concentration contained 1.6 times the amount of pure capsaicin LC50 to achieve the same effect of capsaicin alone. GS and GB capsaicin content at the LC50 value was lower (0.2 and 0.66, respectively) compared to the amount of capsaicin to achieve a similar reduction in cell growth.
authors: Institute of Food, Nutrition and Human Health, College of Health, Massey University , Palmerston North , New Zealand .
authors: David G
authors: DG
authors: Popovich
authors: Sharon Y
authors: SY
authors: Sia
authors: Wei
authors: W
authors: Zhang
authors: Mon L
authors: ML
authors: Lim
mesh_terms: D000818:Animals; D002211:Capsaicin / Q000737:chemistry / Q000494:pharmacology*; D002212:Capsicum / Q000737:chemistry*; D002453:Cell Cycle / Q000187:drug effects; D005638:Fruit / Q000737:chemistry*; D056945:Hep G2 Cells; D022781:Hepatocytes / Q000166:cytology / Q000187:drug effects; D006801:Humans; D010860:Pigments, Biological
chemical_list: D010860:Pigments, Biological; D002211:Capsaicin
keywords: Capsaicin; Capsicum annuum; HepG2; chili; cytotoxicity