title: Vaspin and lipocalin-2 levels in severe obsructive sleep apnea.
abstract: BACKGROUND
  Vaspin and lipocalin-2 are less-known recent members of adipocytokine family. There are ongoing studies investigating the role of vaspin ve lipocalin-2 in metabolic syndrome (MS). Obstructive sleep apnea syndrome (OSAS) is independently associated with an increased prevalence of MS. We aimed to measure the levels of vaspin and lipocalin-2 which are secreted from adipocytes in patients with severe OSAS and examine the relationship between these two adipocytokines and OSAS.
  
  
  METHODS
  THE STUDY CONSISTED OF TWO GROUPS: severe OSAS patients with an apnea-hypopnea index (AHI) of >30/h (OSAS group, 34 subjects) and age-matched healthy volunteers with a AHI <5/h (control group, 25 subjects) Serum levels of vaspin and lipocalin-2 in these two groups were compared.
  
  
  RESULTS
  Serum levels of vaspin were significantly lower in OSAS group; patients with severe OSAS compared with control group; healthy volunteers (OSAS group: 0.69±0.5 vs. control group: 1.24±1.13; P=0.034). The difference between the two groups in terms of serum levels of lipocalin-2 has not reached statistical significance (OSAS group: 61.6±18.2 vs. control group: 68.5±20.1; P=0.17).
  
  
  CONCLUSIONS
  We found that serum vaspin levels were significantly lower in patients with severe OSAS compared with healthy controls. Lipocalin-2 levels were similar. The decrease in serum vaspin levels in severe OSAS patients may be important in diagnosis and follow-up of these patients.
authors: 1 Internal Medicine Clinic, Bezmialem Vakif University, Faculty of Medicine, 34093 Fatih, Istanbul, Turkey ; 2 Deparment Of Pulmonology, 3 Deparment Of Medical Biochemistry, Bezmialem Vakif University, Faculty of Medicine, Fatih 34093, Istanbul, Turkey ; 4 Family Health Care Center, Rize 53100, Turkey.
authors: Muharrem
authors: M
authors: Kiskac
authors: 1 Internal Medicine Clinic, Bezmialem Vakif University, Faculty of Medicine, 34093 Fatih, Istanbul, Turkey ; 2 Deparment Of Pulmonology, 3 Deparment Of Medical Biochemistry, Bezmialem Vakif University, Faculty of Medicine, Fatih 34093, Istanbul, Turkey ; 4 Family Health Care Center, Rize 53100, Turkey.
authors: Mehmet
authors: M
authors: Zorlu
authors: 1 Internal Medicine Clinic, Bezmialem Vakif University, Faculty of Medicine, 34093 Fatih, Istanbul, Turkey ; 2 Deparment Of Pulmonology, 3 Deparment Of Medical Biochemistry, Bezmialem Vakif University, Faculty of Medicine, Fatih 34093, Istanbul, Turkey ; 4 Family Health Care Center, Rize 53100, Turkey.
authors: Muhammed Emin
authors: ME
authors: Akkoyunlu
authors: 1 Internal Medicine Clinic, Bezmialem Vakif University, Faculty of Medicine, 34093 Fatih, Istanbul, Turkey ; 2 Deparment Of Pulmonology, 3 Deparment Of Medical Biochemistry, Bezmialem Vakif University, Faculty of Medicine, Fatih 34093, Istanbul, Turkey ; 4 Family Health Care Center, Rize 53100, Turkey.
authors: Elif
authors: E
authors: Kilic
authors: 1 Internal Medicine Clinic, Bezmialem Vakif University, Faculty of Medicine, 34093 Fatih, Istanbul, Turkey ; 2 Deparment Of Pulmonology, 3 Deparment Of Medical Biochemistry, Bezmialem Vakif University, Faculty of Medicine, Fatih 34093, Istanbul, Turkey ; 4 Family Health Care Center, Rize 53100, Turkey.
authors: Cumali
authors: C
authors: Karatoprak
authors: 1 Internal Medicine Clinic, Bezmialem Vakif University, Faculty of Medicine, 34093 Fatih, Istanbul, Turkey ; 2 Deparment Of Pulmonology, 3 Deparment Of Medical Biochemistry, Bezmialem Vakif University, Faculty of Medicine, Fatih 34093, Istanbul, Turkey ; 4 Family Health Care Center, Rize 53100, Turkey.
authors: Mustafa
authors: M
authors: Cakirca
authors: 1 Internal Medicine Clinic, Bezmialem Vakif University, Faculty of Medicine, 34093 Fatih, Istanbul, Turkey ; 2 Deparment Of Pulmonology, 3 Deparment Of Medical Biochemistry, Bezmialem Vakif University, Faculty of Medicine, Fatih 34093, Istanbul, Turkey ; 4 Family Health Care Center, Rize 53100, Turkey.
authors: Erdinc
authors: E
authors: Yavuz
authors: 1 Internal Medicine Clinic, Bezmialem Vakif University, Faculty of Medicine, 34093 Fatih, Istanbul, Turkey ; 2 Deparment Of Pulmonology, 3 Deparment Of Medical Biochemistry, Bezmialem Vakif University, Faculty of Medicine, Fatih 34093, Istanbul, Turkey ; 4 Family Health Care Center, Rize 53100, Turkey.
authors: Cuneyt
authors: C
authors: Ardic
authors: 1 Internal Medicine Clinic, Bezmialem Vakif University, Faculty of Medicine, 34093 Fatih, Istanbul, Turkey ; 2 Deparment Of Pulmonology, 3 Deparment Of Medical Biochemistry, Bezmialem Vakif University, Faculty of Medicine, Fatih 34093, Istanbul, Turkey ; 4 Family Health Care Center, Rize 53100, Turkey.
authors: Ahmet Adil
authors: AA
authors: Camli
authors: 1 Internal Medicine Clinic, Bezmialem Vakif University, Faculty of Medicine, 34093 Fatih, Istanbul, Turkey ; 2 Deparment Of Pulmonology, 3 Deparment Of Medical Biochemistry, Bezmialem Vakif University, Faculty of Medicine, Fatih 34093, Istanbul, Turkey ; 4 Family Health Care Center, Rize 53100, Turkey.
authors: Mehmetali
authors: M
authors: Cikrikcioglu
authors: 1 Internal Medicine Clinic, Bezmialem Vakif University, Faculty of Medicine, 34093 Fatih, Istanbul, Turkey ; 2 Deparment Of Pulmonology, 3 Deparment Of Medical Biochemistry, Bezmialem Vakif University, Faculty of Medicine, Fatih 34093, Istanbul, Turkey ; 4 Family Health Care Center, Rize 53100, Turkey.
authors: Levent
authors: L
authors: Kart
keywords: Obstructive sleep apnea syndrome (OSAS); lipocalin-2; vaspin