title: Syntheses of [14C]-labeled 2-(3-chlorophenyloxy)-3-[3-(3-hydroxy) pyridin-4-yl propoxy]pyridine, a phosphodiesterase 4 inhibitor and its metabolites.
abstract: We describe here the synthesis of [(14)C]-2-(3-chlorophenyloxy)-3-[3-(3-hydroxy)pyridin-4-yl propoxy]pyridine (1), a phosphodiesterase 4 inhibitor. [(14)C]-Labeled 1 was prepared in three steps from [(14)C]-2-bromopyridin-3-ol in an overall yield of 32%. Preparation of [(14)C]-labeled 2 and 3, two metabolites of 1, is also described.
authors: Drug Research Division, Dainippon Sumitomo Pharma Co., Ltd., 33-94 Enoki-cho, Suita, Osaka, 564-0053, Japan.
authors: Takeshi
authors: T
authors: Ochi
authors: Yusuke
authors: Y
authors: Sawayama
authors: Motoji
authors: M
authors: Kawasaki
authors: Tomohiro
authors: T
authors: Nigo
authors: Masashi
authors: M
authors: Nakao
authors: Tomoki
authors: T
authors: Omodani
authors: Takaaki
authors: T
authors: Sumiyoshi
mesh_terms: D002250:Carbon Radioisotopes / Q000737:chemistry; D058988:Phosphodiesterase 4 Inhibitors / Q000138:chemical synthesis*; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
chemical_list: C000595451:2-(3-chlorophenyloxy)-3-(3-(3-hydroxy)pyridin-4-ylpropoxy)pyridine; D002250:Carbon Radioisotopes; D058988:Phosphodiesterase 4 Inhibitors; D011725:Pyridines; D019275:Radiopharmaceuticals
keywords: 2,3-disubstituted pyridine; PDE4 inhibitor; anti-inflammatory agent; carbon-14; phosphodiesterase 4; radiosynthesis