title: Evaluation of matrix solid-phase dispersion extraction for 11 β-agonists in swine feed by liquid chromatography with electrospray ionization tandem mass spectrometry.
abstract: A sensitive liquid chromatography with tandem mass spectrometry method was developed for the determination of 11 β-agonists (clenbuterol, salbutamol, ractopamine, terbutaline, fenoterol, cimaterol, isoxsuprine, mabuterol, mapenterol, clenproperol, and tulobuterol) in swine feed. This rapid, simple, and effective extraction method was based on matrix solid-phase dispersion. The limit of quantification of clenbuterol, cimaterol, mabuterol, salbutamol, terbutaline, mapenterol, clenproperol, and tulobuterol was 1 μg/kg and that of ractopamine, fenoterol, and isoxsuprine was 2 μg/kg. The recoveries of β-agonists spiked in swine feeds at a concentration range of 1-8 μg/kg were >83.1% with relative standard deviations <9.3%. This rapid and reliable method can be used to efficiently separate, characterize, and quantify the residues of 11 β-agonists in swine feeds with advantages of simple pretreatment and environmental friendliness.
authors: National Reference Laboratory of Veterinary Drug Residues (HZAU)/MOA Key Laboratory of Food Safety Evaluation, Huazhong Agricultural University, Wuhan, China.
authors: Yanfei
authors: Y
authors: Tao
authors: Fangwei
authors: F
authors: Zhu
authors: Dongmei
authors: D
authors: Chen
authors: Shuyu
authors: S
authors: Xie
authors: Pan
authors: P
authors: Yuanhu
authors: Xu
authors: X
authors: Wang
authors: Zhenli
authors: Z
authors: Liu
authors: Dapeng
authors: D
authors: Peng
authors: Zonghui
authors: Z
authors: Yuan
mesh_terms: D000318:Adrenergic beta-Agonists / Q000008:administration & dosage / Q000302:isolation & purification*; D000821:Animal Feed / Q000032:analysis*; D000818:Animals; D002853:Chromatography, Liquid; D015394:Molecular Structure; D052616:Solid Phase Extraction; D021241:Spectrometry, Mass, Electrospray Ionization; D013552:Swine; D053719:Tandem Mass Spectrometry
chemical_list: D000318:Adrenergic beta-Agonists
keywords: Feed; Matrix solid-phase dispersion; Tandem mass spectrometry; β-Agonists