title: Comparison of muscle paralysis after intravenous and intraosseous administration of succinylcholine in Swine.
abstract: OBJECTIVE
  To compare the onset and duration of intravenous (IV) and intraosseous (IO) administration of succinylcholine in swine.
  
  
  METHODS
  Electromyographic (EMG) amplitudes were used to characterize muscle paralysis following administration of succinylcholine via the IV or IO route in four Yorkshire-cross swine.
  
  
  RESULTS
  The onset of action of succinylcholine was statistically longer after IO administration (0.97±0.40) compared with IV administration (0.55±0.26) (p=.048). Duration of action was unaffected by route of administration: IO, 11.4±4.2, and IV, 12.9±3.8 (p=.65).
  
  
  CONCLUSIONS
  Succinylcholine can be effectively administered via the IO route. However, an increased dose may be necessary when administering succinylcholine via the IO route to achieve the same rapid onset as standard IV dosing.
authors: Michael J
authors: MJ
authors: Loughren
authors: James
authors: J
authors: Kilbourn
authors: Kevin
authors: K
authors: Worth
authors: James
authors: J
authors: Burgert
authors: Brian
authors: B
authors: Gegel
authors: Don
authors: D
authors: Johnson
mesh_terms: D061605:Administration, Intravenous; D000818:Animals; D018592:Cross-Over Studies; D004576:Electromyography; D017148:Infusions, Intraosseous; D018482:Muscle, Skeletal / Q000187:drug effects*; D019148:Neuromuscular Blockade / Q000379:methods*; D009467:Neuromuscular Depolarizing Agents / Q000008:administration & dosage* / Q000494:pharmacology; D010243:Paralysis; D013390:Succinylcholine / Q000008:administration & dosage* / Q000494:pharmacology; D034421:Sus scrofa; D013552:Swine
chemical_list: D009467:Neuromuscular Depolarizing Agents; D013390:Succinylcholine