title: Synthesis of hollow mesoporous silica nanoparticles with tunable shell thickness and pore size using amphiphilic block copolymers as core templates.
abstract: This paper presents a facile method for the fabrication of uniform hollow mesoporous silica nanoparticles (HMSNs) with tunable shell thickness and pore size. In this method, a series of amphiphilic block copolymers of polystyrene-b-poly (acrylic acid) (PS-b-PAA) with different hydrophobic block (PS) lengths were first synthesized via atom transfer radical polymerization (ATRP). The as-synthesized PS-b-PAA and cetyltrimethylammonium bromide (CTAB) were subsequently used as co-templates to fabricate HMSNs. This approach allows the control of shell thickness and pore size distribution of the synthesized HMSNs simply by changing the amounts of PS-b-PAA and CTAB, respectively. In vitro cytotoxicity and hemolysis assays demonstrated that the synthesized HMSNs had a low and shell thickness-dependent cytotoxicity and hemolytic activity. Therefore, these HMSNs have great potential for biomedical applications due to their good biocompatibility and ease of synthesis.
authors: College of Chemistry, Chemical Engineering and Biotechnology, State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, Shanghai 201620, People's Republic of China. hcl@dhu.edu.cn.
authors: Xiaojun
authors: X
authors: Zhou
authors: Xiao
authors: X
authors: Cheng
authors: Wei
authors: W
authors: Feng
authors: Kexin
authors: K
authors: Qiu
authors: Liang
authors: L
authors: Chen
authors: Wei
authors: W
authors: Nie
authors: Zhiqi
authors: Z
authors: Yin
authors: Xiumei
authors: X
authors: Mo
authors: Hongsheng
authors: H
authors: Wang
authors: Chuanglong
authors: C
authors: He
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D000077286:Cetrimonium; D002593:Cetrimonium Compounds / Q000737:chemistry; D004912:Erythrocytes / Q000187:drug effects; D006367:HeLa Cells; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D011137:Polystyrenes / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry* / Q000494:pharmacology; D013501:Surface-Active Agents / Q000737:chemistry
chemical_list: D000179:Acrylates; D002593:Cetrimonium Compounds; D011137:Polystyrenes; D013501:Surface-Active Agents; C509855:poly(styrene-b-acrylic acid); D012822:Silicon Dioxide; D000077286:Cetrimonium