title: Impaired hepatic Gd-EOB-DTPA enhancement after radioembolisation of liver malignancies.
abstract: BACKGROUND
  To evaluate the uptake of the liver-specific magnetic resonance imaging (MRI) contrast agent gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) by functional liver parenchyma after radioembolisation (RE) of hepatic malignancies.
  
  
  METHODS
  Uptake of Gd-EOB-DTPA prior to RE versus 60+/-24d and 126+/-32d after RE was compared in a group of 33 patients with primary or secondary hepatic malignancies. In patients who underwent single-lobe treatment, left and right lobes were compared 59+/-24 days after RE. Gd-EOB-DTPA uptake was determined as follows: ratio of mean signal intensity in liver parenchyma to muscle in Gd-EOB-DTPA-enhanced T1-weighted MRI was subtracted from ratio of mean intensity in liver parenchyma to muscle in unenhanced T1-weighted MRI.
  
  
  RESULTS
  Gd-EOB-DTPA uptake in liver parenchyma was 0.845+/-0.29 before RE, 0.615+/-0.38 (P = 0.0022) at day 60+/-24, and 0.739+/-0.30 at day 126+/-32 after RE. In cases of single-lobe treatment, Gd-EOB-DTPA uptake was 0.581+/-0.256 for treated and 0.828+/-0.32 (P = 0.0164) for untreated hepatic lobes.
  
  
  CONCLUSIONS
  Uptake of Gd-EOB-DTPA by liver parenchyma is impaired after RE, indicating dysfunction of the local hepatic system. These findings suggest that Gd-EOB-DTPA-enhanced MRI has the potential to be used for monitoring liver damage after RE.
authors: Department of Radiology and Nuclear Medicine, Otto-von-Guericke University, Magdeburg, Germany.
authors: Maciej Janusz
authors: MJ
authors: Powerski
authors: Christian
authors: C
authors: Scheurig-Münkler
authors: Bernd
authors: B
authors: Hamm
authors: Bernhard
authors: B
authors: Gebauer
mesh_terms: D000368:Aged; D001918:Brachytherapy / Q000009:adverse effects*; D003287:Contrast Media / Q000493:pharmacokinetics; D005260:Female; D019786:Gadolinium DTPA / Q000493:pharmacokinetics; D006801:Humans; D017093:Liver Failure / Q000000981:diagnostic imaging* / Q000209:etiology* / Q000378:metabolism; D008113:Liver Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism / Q000532:radiotherapy*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries / Q000000981:diagnostic imaging* / Q000209:etiology* / Q000378:metabolism; D011877:Radionuclide Imaging; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D016896:Treatment Outcome
chemical_list: D003287:Contrast Media; C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA
keywords: Gd-EOB-DTPA uptake; MRI; SIRT); liver tumour; radioembolisation (RE