title: Management of periorbital hemangioma by intralesional glucocorticoids and systemic propranolol: a single-center retrospective study.
abstract: Periorbital hemangioma may lead to the vision impairment so effective treatment should be adopted in time. In this study, we made a retrospective analysis of intralesional glucocorticoids and systemic propranolol in the management of periorbital hemangioma. From Jan. 2006 to Dec. 2013, twenty-five children with periorbital hemangioma were enrolled into this study. Among them, sixteen children accepted intralesional injection of compound betamethasone preparation. Eight children accepted systemic propranolol. One child accepted both of the two treatments. The follow-up period ranged from 6 months to 60 months. The results showed that in the patients with intralesional compound betamethasone preparation, 13/16 patients' tumors involuted completely. 3/16 patients' tumors didn't involute completely at the end of follow-up. In the patients with systemic propranolol, 8/8 patients' tumors involuted almost completely. One patient didn't respond to intralesional glucocorticoids, and so switched to systemic propranolol, which lead to the involution of tumor finally. The adverse effects in the patients with intralesional glucocorticoids included local soft tissue atrophy, local ulcer, and Cushing-like manifestations, which occurred in three patients respectively. In the patients with systemic propranolol, mild diarrhoea occurred in one child. According to our observation, both of intralesional glucocorticoids and systemic propranolol achieved good results in the management of periorbital hemangioma. Systemic propranolol showed superiority in efficacy and safety. We recommend systemic propranolol as the first-line therapy. However, for the children who can't tolerate systemic propranolol, intralesional glucocorticoids still is a feasible choice.
authors: Department of Plastic Surgery, Jinling Hospital, School of Medicine, Nanjing University Nanjing, Jiangsu, China.
authors: Si-Ming
authors: SM
authors: Yuan
authors: Department of Plastic Surgery, Jinling Hospital, School of Medicine, Nanjing University Nanjing, Jiangsu, China.
authors: Lei
authors: L
authors: Cui
authors: Department of Plastic Surgery, Jinling Hospital, School of Medicine, Nanjing University Nanjing, Jiangsu, China.
authors: Yao
authors: Y
authors: Guo
authors: Department of Ophthalmology, Jinling Hospital, School of Medicine, Nanjing University Nanjing, Jiangsu, China.
authors: Chun-Yan
authors: CY
authors: Xue
authors: Department of Plastic Surgery, Jinling Hospital, School of Medicine, Nanjing University Nanjing, Jiangsu, China.
authors: Zhi-Jian
authors: ZJ
authors: Hong
authors: Department of Plastic Surgery, Jinling Hospital, School of Medicine, Nanjing University Nanjing, Jiangsu, China.
authors: Hui-Qing
authors: HQ
authors: Jiang
keywords: Periorbital hemangioma; intralesional glucocorticoids; systemic propranolol