title: Characterization of sheep pox virus vaccine for cattle against lumpy skin disease virus.
abstract: Lumpy skin disease is of significant economic impact for the cattle industry in Africa. The disease is currently spreading aggressively in the Near East, posing a threat of incursion to Europe and Asia. Due to cross-protection within the Capripoxvirus genus, sheep pox virus (SPPV) vaccines have been widely used for cattle against lumpy skin disease virus (LSDV). In the Middle East and the Horn of Africa these vaccines have been associated with incomplete protection and adverse reactions in cattle post-vaccination. The present study confirms that the real identity of the commonly used Kenyan sheep and goat pox vaccine virus (KSGP) O-240 is not SPPV but is actually LSDV. The low level attenuation of this virus is likely to be not sufficient for safe use in cattle, causing clinical disease in vaccinated animals. In addition, Isiolo and Kedong goat pox strains, capable of infecting sheep, goats and cattle are identified for potential use as broad-spectrum vaccine candidates against all capripox diseases.
authors: The Pirbright Institute, Ash Road, Pirbright, Surrey GU24 0NF, UK. Electronic address: eeva.tuppurainen@pirbright.ac.uk.
authors: Eeva S M
authors: ES
authors: Tuppurainen
authors: The Pirbright Institute, Ash Road, Pirbright, Surrey GU24 0NF, UK.
authors: Caroline R
authors: CR
authors: Pearson
authors: The Pirbright Institute, Ash Road, Pirbright, Surrey GU24 0NF, UK.
authors: Katarzyna
authors: K
authors: Bachanek-Bankowska
authors: The Pirbright Institute, Ash Road, Pirbright, Surrey GU24 0NF, UK.
authors: Nick J
authors: NJ
authors: Knowles
authors: Jordan Bio-Industries Centre (JOVAC), PO Box 43, Amman 11941, Jordan.
authors: Shadi
authors: S
authors: Amareen
authors: The Pirbright Institute, Ash Road, Pirbright, Surrey GU24 0NF, UK.
authors: Lorraine
authors: L
authors: Frost
authors: The Pirbright Institute, Ash Road, Pirbright, Surrey GU24 0NF, UK.
authors: Mark R
authors: MR
authors: Henstock
authors: Animal Production and Health Laboratory, Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture, Department of Nuclear Sciences and Applications, International Atomic Energy Agency, Wagramer Strasse 5, P.O. Box 100, A-1400 Vienna, Austria.
authors: Charles E
authors: CE
authors: Lamien
authors: Animal Production and Health Laboratory, Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture, Department of Nuclear Sciences and Applications, International Atomic Energy Agency, Wagramer Strasse 5, P.O. Box 100, A-1400 Vienna, Austria.
authors: Adama
authors: A
authors: Diallo
authors: The Pirbright Institute, Ash Road, Pirbright, Surrey GU24 0NF, UK.
authors: Peter P C
authors: PP
authors: Mertens
mesh_terms: D000818:Animals; D018151:Capripoxvirus / Q000145:classification / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D002417:Cattle; D015511:Goat Diseases / Q000821:virology; D006041:Goats; D008166:Lumpy Skin Disease / Q000517:prevention & control / Q000821:virology*; D008167:Lumpy skin disease virus / Q000145:classification / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D008969:Molecular Sequence Data; D010802:Phylogeny; D012756:Sheep; D012757:Sheep Diseases / Q000821:virology; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000145:classification / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D014765:Viral Vaccines / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*
chemical_list: D014613:Vaccines, Attenuated; D014765:Viral Vaccines
keywords: Kenyan sheep and goat pox virus; Lumpy skin disease; Vaccine