title: Host-guest interactions in Fe(III)-trimesate MOF nanoparticles loaded with doxorubicin.
abstract: Doxorubicin (DOX) entrapment in porous Fe(III)-trimesate metal organic frameworks (MIL-100(Fe)) nanoparticles was investigated in neutral Tris buffer via UV-vis absorption, circular dichroism (CD), and fluorescence. The binding constants and the absolute spectra of the DOX-MIL-100(Fe) complexes were determined via absorption and fluorescence titrations. A binding model where DOX associates as monomer to the dehydrated Fe3O (OH)(H2O)2 [(C6H3)(CO2)3]2 structural unit in 1:1 stoichiometry, with apparent association constant of (1.1 to 1.8) × 10(4) M(-1), was found to reasonably fit the experimental data. Spectroscopic data indicate that DOX binding occurs via the formation of highly stable coordination bonds between one or both deprotonated hydroxyl groups of the aglycone moiety and coordinatively unsaturated Fe(III) centers. Complete quenching of the DOX fluorescence and remarkable thermal and photochemical stability were observed for DOX incorporated in the MIL-100(Fe) framework.
authors: Istituto per la Sintesi Organica e la Fotoreattività, ISOF-CNR , Via Piero Gobetti 101, Bologna I-40129, Italy.
authors: Resmi
authors: R
authors: Anand
authors: Francesco
authors: F
authors: Borghi
authors: Francesco
authors: F
authors: Manoli
authors: Ilse
authors: I
authors: Manet
authors: Valentina
authors: V
authors: Agostoni
authors: Pierluigi
authors: P
authors: Reschiglian
authors: Ruxandra
authors: R
authors: Gref
authors: Sandra
authors: S
authors: Monti
mesh_terms: D004317:Doxorubicin / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D004355:Drug Stability; D005609:Free Radicals / Q000737:chemistry; D007501:Iron / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D053758:Nanoparticles / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D016062:Porosity
chemical_list: D004337:Drug Carriers; D005609:Free Radicals; D009942:Organometallic Compounds; D004317:Doxorubicin; D007501:Iron