title: Notch-1 and Ki-67 receptor as predictors for the recurrence and prognosis of Kimura's disease.
abstract: Kimura's disease (KD) is a rare chronic disease with unknown origin. It remains controversial in KD's diagnosis, treatment, transformation and need further research. The aim of this study is to investigate the clinicopathologic features of KD and the relationship between the expression of Notch-1, Ki-67 receptor and the recurrence of KD. The hematoxylin and eosin sections and clinical data of 40 patients diagnosed with KD were examined retrospectively. Specimens were available in these 40 cases. Notch-1 and Ki-67 expression were examined using IHC (immunohistochemistry staining) analysis. Of 40 cases of KD (average age, 38.4 years; median age, 36.0 years), 34 cases (85.0%) were clinically seen to involve swelling of the head and neck region. Notch-1 and Ki-67 have a high expression in recurrent patients. High expression of Notch-1 receptor and Ki-67 tended to be found in patients who relapsed. This is the first study to discuss the correlation among Notch-1, Ki-67 and recurrent KD. These results suggest both of the markers may act as promising predictors for the recurrence and prognosis of KD. However, Notch-1 immunoexpression had no statistically significant association with the Ki-67 proliferation index.
authors: Department of Head and Neck Surgery, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine 651 Dongfeng East Road, Guangzhou City, Guangdong Province, China.
authors: Wei-Ye
authors: WY
authors: Deng
authors: Department of Experimental Research, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine 651 Dongfeng East Road, Guangzhou City, Guangdong Province, China.
authors: Shu-Biao
authors: SB
authors: Ye
authors: Department of Pathology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine 651 Dongfeng East Road, Guangzhou City, Guangdong Province, China.
authors: Rong-Zhen
authors: RZ
authors: Luo
authors: Department of Pathology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine 651 Dongfeng East Road, Guangzhou City, Guangdong Province, China.
authors: Shu-Mei
authors: SM
authors: Yan
authors: Department of Head and Neck Surgery, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine 651 Dongfeng East Road, Guangzhou City, Guangdong Province, China.
authors: Yun-Fei
authors: YF
authors: Gao
authors: Department of Pathology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine 651 Dongfeng East Road, Guangzhou City, Guangdong Province, China.
authors: Yuan-Zhong
authors: YZ
authors: Yang
authors: Department of Head and Neck Surgery, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine 651 Dongfeng East Road, Guangzhou City, Guangdong Province, China.
authors: Zhu-Ming
authors: ZM
authors: Guo
authors: Department of Head and Neck Surgery, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine 651 Dongfeng East Road, Guangzhou City, Guangdong Province, China.
authors: Yan-Feng
authors: YF
authors: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000796:Angiolymphoid Hyperplasia with Eosinophilia / Q000378:metabolism* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D049109:Cell Proliferation; D002648:Child; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D019394:Ki-67 Antigen / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D051881:Receptor, Notch1 / Q000032:analysis*; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D040521:Subcutaneous Tissue / Q000737:chemistry* / Q000473:pathology; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015415:Biomarkers; D019394:Ki-67 Antigen; C497761:NOTCH1 protein, human; D051881:Receptor, Notch1
keywords: Ki-67 proliferation index; Kimura’s disease (KD); Notch-1 receptor; recurrence