title: Two Clinically Unusual Cases of Folliculotropic Mycosis Fungoides: One with and the Other without Syringotropism.
abstract: Mycosis fungoides is the most common form of cutaneous T-cell lymphoma, and it rarely exhibits predilection for hair follicle and eccrine gland infiltration. Here, we present 2 similar cases that display folliculotropism with varying amounts of follicular mucinosis, with and without syringotropism. The features observed in both cases were cystic, comedo-like, acneiform lesions; generalized involvement with loss of body hair; pruritus; and hidradenitis suppurativa-like lesions. Hypohidrosis as well as nail and palmoplantar involvement with lichen planopilaris-like clinical features were unique characteristics of the first case. Despite the well-known aggressive behavior of follicular mycosis fungoides, the presented cases had a subtle, slowly progressive, but persistent, clinical course. Folliculotropic and syringotropic mycosis fungoides are variants of cutaneous T-cell lymphoma. Clinical presentations might be challenging, and multiple, deep biopsy specimens containing adnexal structures are required for this critical diagnosis. Aggressive treatment may not be necessary in cases having an indolent course, especially in those with syringotropism.
authors: Department of Dermatology, School of Medicine, Acibadem University, Istanbul, Turkey.
authors: Ozgür
authors: O
authors: Bakar
authors: Department of Dermatology, School of Medicine, Marmara University, Istanbul, Turkey.
authors: Dilek
authors: D
authors: Seçkin
authors: Department of Pathology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors: Cuyan
authors: C
authors: Demirkesen
authors: Department of Dermatology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
authors: Can
authors: C
authors: Baykal
authors: Department of Pathology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
authors: Nesimi
authors: N
authors: Büyükbabani
keywords: Adnexal; Eccrine gland; Follicle; Lymphoma; Mycosis fungoides; Neoplasm