title: Dynamic light scattering and X-ray photoelectron spectroscopy characterization of PEGylated polymer nanocarriers: internal structure and surface properties.
abstract: In this work, nanospheres and nanocapsules are precipitated in confined impinging jet mixers through solvent displacement and characterized. Acetone and water are used as the solvent and antisolvent, respectively, together with polymethoxypolyethylene glycol cyanoacrylate-co-hexadecylcyanoacrylate and Miglyol as the copolymer and oil, respectively. Characterization is performed with dynamic light scattering, with electrophoretic measurements, and for the first time with X-ray photoelectron spectroscopy. Results show that the presence of polyethylene glycol chains seems to be more pronounced on the surface of nanospheres than on that of nanocapsules. The thickness of the copolymer layer in nanocapsules ranges from 1 to 10 nm, depending on the value of the oil:copolymer mass ratio. Fast dilution is confirmed to have a positive effect in suppressing aggregation but can induce further copolymer precipitation.
authors: Dipartimento di Fisica, Università di Genova , via Dodecaneso 33, 16146 Genova, Italy.
authors: Edvige
authors: E
authors: Celasco
authors: Ilaria
authors: I
authors: Valente
authors: Daniele L
authors: DL
authors: Marchisio
authors: Antonello A
authors: AA
authors: Barresi
mesh_terms: D003487:Cyanoacrylates / Q000737:chemistry*; D053769:Nanocapsules / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D056951:Photoelectron Spectroscopy; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
chemical_list: D003487:Cyanoacrylates; D053769:Nanocapsules; D011108:Polymers; D011092:Polyethylene Glycols