title: Intrahepatic cholangiocarcinoma in a transplant liver--selective internal radiation therapy followed by right hemihepatectomy: report of a case.
abstract: Intra- or extrahepatic cholangiocarcinomas are the second most common primary liver malignancies behind hepatocellular carcinoma. Whereas the incidence for intrahepatic cholangiocarcinoma is rising, the occurrence of extrahepatic cholangiocarcinoma is trending downwards. The treatment of choice for intrahepatic cholangiocarcinoma remains liver resection. However, a case of liver resection after selective internal radiation therapy in order to treat a recurrent intrahepatic cholangiocarcinoma in a transplant liver is unknown in the literature so far. Herein, we present a case of a patient undergoing liver transplantation for Wilson's disease with an accidental finding of an intrahepatic cholangiocarcinoma within the explanted liver. Due to a recurrent intrahepatic cholangiocarcinoma after liver transplantation, a selective internal radiation therapy with yttrium-90 microspheres was performed followed by right hemihepatectomy. Four years later, the patient is tumor-free and in a healthy condition.
authors: Jens
authors: J
authors: Sperling
authors: Christoph
authors: C
authors: Justinger
authors: Jochen
authors: J
authors: Schuld
authors: Christian
authors: C
authors: Ziemann
authors: Roland
authors: R
authors: Seidel
authors: Present address: Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Georg August University, D-37075 Göttingen, Germany. otto.kollmar@med.uni-goettingen.de.
authors: Otto
authors: O
authors: Kollmar
mesh_terms: D001650:Bile Duct Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D001653:Bile Ducts, Intrahepatic / Q000473:pathology; D001918:Brachytherapy; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D018281:Cholangiocarcinoma / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D003131:Combined Modality Therapy; D004621:Embolization, Therapeutic; D006498:Hepatectomy; D006527:Hepatolenticular Degeneration / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D016031:Liver Transplantation / Q000009:adverse effects*; D008863:Microspheres; D008875:Middle Aged; D011379:Prognosis; D015021:Yttrium Radioisotopes / Q000627:therapeutic use
chemical_list: D015021:Yttrium Radioisotopes