title: Farnesoid X receptor immunolocalization in reproductive tissues of adult female rabbits.
abstract: Farnesoid X receptor (FXR) has been involved in lipid metabolism, cell proliferation, apoptosis, and aromatase expression, as well as in the steroid synthesis and signaling. Considering that these events occur in reproductive tissues in females, the aim of the present study was to determine the immunolocalization of FXR in the ovary, oviduct, uterus, and vagina of rabbits. Rabbits were sacrificed and their reproductive tissues were excised and histologically processed. Immunohistochemistry for FXR was done and reproductive tissues were photographed. FXR immunoreactivity was found in all types of ovarian follicles, ovarian stroma, and corpus luteum of virgin and pregnant rabbits. Also, oviductal and vaginal epithelium of virgins, as well as the oviductal smooth muscle, showed anti-FXR immunoreactivity. The uterine epithelium and musculature of virgins had scarce anti-FXR immunoreactivity. Although the role of FXR in female reproductive tissues is still not known, it is possible to consider various functions related to the reproductive tissue.
authors: Doctorado en Neuroetología, Universidad Veracruzana, Xalapa, México.
authors: Arely
authors: A
authors: Anaya-Hernández
authors: Maestría en Ciencias Biológicas, Universidad Autónoma de Tlaxcala, Tlaxcala, México.
authors: Maribel
authors: M
authors: Méndez-Tepepa
authors: Doctorado en Ciencias Biológicas, Universidad Autónoma de Tlaxcala, Tlaxcala, México.
authors: Laura G
authors: LG
authors: Hernández-Aragón
authors: Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México, DF, México.
authors: Pablo
authors: P
authors: Pacheco
authors: Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México, DF, México; Centro Tlaxcala de Biología de la Conducta, Universidad Autónoma de Tlaxcala, Tlaxcala, México.
authors: Margarita
authors: M
authors: Martínez-Gómez
authors: Centro Tlaxcala de Biología de la Conducta, Universidad Autónoma de Tlaxcala, Tlaxcala, México.
authors: Francisco
authors: F
authors: Castelán
authors: Centro Tlaxcala de Biología de la Conducta, Universidad Autónoma de Tlaxcala, Tlaxcala, México. Electronic address: ecuevas@uatx.mx.
authors: Estela
authors: E
authors: Cuevas
mesh_terms: D000818:Animals; D004847:Epithelial Cells / Q000378:metabolism; D005260:Female; D007150:Immunohistochemistry; D009928:Organ Specificity; D010053:Ovary / Q000166:cytology / Q000378:metabolism*; D010057:Oviducts / Q000166:cytology / Q000378:metabolism*; D011817:Rabbits; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D014521:Urethra / Q000378:metabolism; D014599:Uterus / Q000166:cytology / Q000378:metabolism*; D014621:Vagina / Q000166:cytology / Q000378:metabolism*; D000099150:Receptor, Farnesoid X-Activated
chemical_list: D018160:Receptors, Cytoplasmic and Nuclear; D000099150:Receptor, Farnesoid X-Activated
keywords: Ovary; Oviduct; Oviductal crypts; Rabbit; Reproduction; Uterus; Vagina