title: Milk protein fractions moderately extend the duration of satiety compared with carbohydrates independently of their digestive kinetics in overweight subjects.
abstract: Digestive kinetics are believed to modulate satiety through the modulation of nutrient delivery. We hypothesised that the duration of satiety could be extended by modulating the kinetics of dietary amino acid delivery in overweight subjects, using snacks containing casein and whey protein. In the present study, eighty-two subjects underwent a first satiety test where they received a control snack containing 60 g maltodextrin. For the next 5 d, the subjects consumed a liquid protein snack containing 30 g carbohydrates and 30 g proteins (casein, whey protein or an equal mix of the two; n 26-28 per group). The subjects then underwent a second satiety test after ingesting the protein snack. The time period elapsing between the snack and request for lunch, food intake at lunch and satiety scores were recorded. A subgroup of twenty-four subjects underwent a digestive and metabolic investigation after ingesting their protein snack. Gastric emptying times were 2·5, 4 and 6 h for whey protein, mix and casein, respectively, displaying different kinetics of appearance of dietary N in plasma but without affecting pancreatic and gastrointestinal hormones. Compared with the control snack, proteins extended the duration of satiety (+17 min, P= 0·02), with no difference between the protein groups. The satiating effect of proteins was greater in subjects who ate their lunch early after the snack (below the median value, i.e. 2 h) at the control test (+32 min, P= 0·001). Energy intake at lunch was not modulated by proteins. The satiating effect of proteins is efficient in overweight subjects, especially when the duration of satiety is short, but independently of their digestive and plasma amino acid kinetics.
authors: INRA, CRNH-IdF, UMR 914 Nutrition Physiology and Ingestive Behavior,F-75005Paris,France.
authors: Agnès
authors: A
authors: Marsset-Baglieri
authors: INRA, CRNH-IdF, UMR 914 Nutrition Physiology and Ingestive Behavior,F-75005Paris,France.
authors: Gilles
authors: G
authors: Fromentin
authors: INRA, CRNH-IdF, UMR 914 Nutrition Physiology and Ingestive Behavior,F-75005Paris,France.
authors: Gheorghe
authors: G
authors: Airinei
authors: INRA, CRNH-IdF, UMR 914 Nutrition Physiology and Ingestive Behavior,F-75005Paris,France.
authors: Camilla
authors: C
authors: Pedersen
authors: INRA, AgroCampus Ouest, UMR STLO,F-35000Rennes,France.
authors: Joëlle
authors: J
authors: Léonil
authors: INRA, CRNH-IdF, UMR 914 Nutrition Physiology and Ingestive Behavior,F-75005Paris,France.
authors: Julien
authors: J
authors: Piedcoq
authors: INRA, UMR 1019 Nutrition Humaine,F-63122 Saint Genès,Champanelle,France.
authors: Didier
authors: D
authors: Rémond
authors: INRA, CRNH-IdF, UMR 914 Nutrition Physiology and Ingestive Behavior,F-75005Paris,France.
authors: Robert
authors: R
authors: Benamouzig
authors: INRA, CRNH-IdF, UMR 914 Nutrition Physiology and Ingestive Behavior,F-75005Paris,France.
authors: Daniel
authors: D
authors: Tomé
authors: INRA, CRNH-IdF, UMR 914 Nutrition Physiology and Ingestive Behavior,F-75005Paris,France.
authors: Claire
authors: C
authors: Gaudichon
mesh_terms: D000328:Adult; D001069:Appetite Regulation; D001628:Beverages; D015992:Body Mass Index; D002364:Caseins / Q000378:metabolism / Q000627:therapeutic use; D004040:Dietary Carbohydrates / Q000378:metabolism / Q000627:therapeutic use; D004063:Digestion; D002149:Energy Intake; D005260:Female; D005526:Food, Formulated; D005746:Gastric Emptying; D006801:Humans; D062409:Lunch; D008297:Male; D008894:Milk Proteins / Q000378:metabolism / Q000627:therapeutic use*; D050177:Overweight / Q000178:diet therapy* / Q000378:metabolism; D015203:Reproducibility of Results; D012528:Satiety Response; D016037:Single-Blind Method; D062410:Snacks; D000067816:Whey Proteins; D055815:Young Adult
chemical_list: D002364:Caseins; D004040:Dietary Carbohydrates; D008894:Milk Proteins; D000067816:Whey Proteins