title: Modafinil effects on middle-frequency oscillatory power during rule selection in schizophrenia.
abstract: Control-related cognitive processes such as rule selection are associated with cortical oscillations in the theta, alpha and, beta ranges, and modulated by catecholamine neurotransmission. Thus, a potential strategy for improving cognitive control deficits in schizophrenia would be to use pro-catecholamine pharmacological agents to augment these control-related oscillations. In a double-blind, placebo-controlled (within-subjects) study, we tested the effects of adjunctive single-dose modafinil 200 mg on rule-related 4-30 Hz oscillations in 23 stable schizophrenia patients, using EEG during cognitive control task performance. EEG data underwent time-frequency decomposition with Morlet wavelets to determine the power of 4-30 Hz oscillations. Modafinil (relative to placebo) enhanced oscillatory power associated with high-control rule selection in theta, alpha, and beta ranges, with modest effects during rule maintenance. Modafinil treatment in schizophrenia augments middle-frequency cortical oscillatory power associated with rule selection, and may subserve diverse subcomponent processes in proactive cognitive control.
authors: Department of Psychiatry, University of California, San Francisco School of Medicine, and San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
authors: Michael J
authors: MJ
authors: Minzenberg
authors: Department of Psychiatry, Stanford University School of Medicine, and Palo Alto Veterans Affairs Medical Center, Palo Alto, CA, USA.
authors: Jong H
authors: JH
authors: Yoon
authors: Department of Psychiatry, University of California, San Francisco School of Medicine, and San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
authors: Yaoan
authors: Y
authors: Cheng
authors: 1] Department of Psychiatry, University of California, Davis School of Medicine, Sacramento, CA, USA [2] Center for Neuroscience, University of California, Davis, CA, USA.
authors: Cameron S
authors: CS
authors: Carter
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001559:Benzhydryl Compounds / Q000494:pharmacology / Q000627:therapeutic use*; D058256:Brain Waves / Q000187:drug effects*; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology*; D003072:Cognition Disorders / Q000188:drug therapy; D004311:Double-Blind Method; D004569:Electroencephalography; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D008297:Male; D000077408:Modafinil; D009483:Neuropsychological Tests; D012189:Retrospective Studies; D012559:Schizophrenia / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D013997:Time Factors; D064690:Wakefulness-Promoting Agents / Q000494:pharmacology* / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D001559:Benzhydryl Compounds; D064690:Wakefulness-Promoting Agents; D000077408:Modafinil