title: Subchronic toxicity, toxicity to reproduction and prenatal developmental toxicity of vinyl laurate.
abstract: Vinyl laurate (VL), is used in the manufacture of polyvinyl acetate vinyl laurate copolymer a component of gum base for chewing gum production. The potential toxicity of VL to reproduction was examined in a combined repeated dose and reproduction/developmental toxicity screening study (OECD test guideline 422) and a prenatal developmental toxicity screening study (OECD test guideline 414). VL was administered to Wistar rats by gavage at 0 (controls), 50, 250 and 1000mg/kgbw/d. There were no signs of systemic toxicity in the parental animals of either study. Adverse effects on reproductive performance and fetal development that could be attributed to the VL treatment were not observed. Thus, the highest dose level tested was a NOAEL in these two studies.
authors: Bioresco Ltd., Bundesstrasse 29, 4054 Basel, Switzerland.
authors: Horst
authors: H
authors: Messinger
authors: Bioresco Ltd., Bundesstrasse 29, 4054 Basel, Switzerland. Electronic address: contact@bioresco.ch.
authors: Albert
authors: A
authors: Bär
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D047109:Fetal Development / Q000187:drug effects*; D007848:Laurates / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D019055:No-Observed-Adverse-Effect Level; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D012098:Reproduction / Q000187:drug effects*; D059550:Toxicity Tests, Subchronic
chemical_list: D007848:Laurates
keywords: CAS 2146-71-6; Prenatal development toxicity; Repeated dose toxicity; Reproduction toxicity; Vinyl laurate