title: Photobacteriosis: prevention and diagnosis.
abstract: Photobacteriosis or fish pasteurellosis is a bacterial disease affecting wild and farm fish. Its etiological agent, the gram negative bacterium Photobacterium damselae subsp. piscicida, is responsible for important economic losses in cultured fish worldwide, in particular in Mediterranean countries and Japan. Efforts have been focused on gaining a better understanding of the biology of the pathogenic microorganism and its natural hosts with the aim of developing effective vaccination strategies and diagnostic tools to control the disease. Conventional vaccinology has thus far yielded unsatisfactory results, and recombinant technology has been applied to identify new antigen candidates for the development of subunit vaccines. Furthermore, molecular methods represent an improvement over classical microbiological techniques for the identification of P. damselae subsp. piscicida and the diagnosis of the disease. The complete sequencing, annotation, and analysis of the pathogen genome will provide insights into the pathogen laying the groundwork for the development of vaccines and diagnostic methods.
authors: Department of Biomolecular Science, Biotechnology Section, University of Urbino "Carlo Bo", Via Arco d'Augusto 2, 61032 Fano, Italy.
authors: Francesca
authors: 0000-0002-4857-8210
authors: F
authors: Andreoni
authors: Department of Biomolecular Science, Biotechnology Section, University of Urbino "Carlo Bo", Via Arco d'Augusto 2, 61032 Fano, Italy.
authors: Mauro
authors: 0000-0001-6456-6626
authors: M
authors: Magnani
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000235:genetics* / Q000276:immunology; D024881:Drug Resistance, Bacterial; D005393:Fish Diseases / Q000175:diagnosis* / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D005399:Fishes; D016680:Genome, Bacterial; D016905:Gram-Negative Bacterial Infections / Q000175:diagnosis / Q000276:immunology / Q000517:prevention & control* / Q000662:veterinary*; D010776:Photobacterium / Q000187:drug effects / Q000235:genetics* / Q000276:immunology; D017422:Sequence Analysis, DNA; D014611:Vaccination; D022223:Vaccines, Subunit; D014614:Vaccines, Synthetic
chemical_list: D000900:Anti-Bacterial Agents; D001428:Bacterial Vaccines; D022223:Vaccines, Subunit; D014614:Vaccines, Synthetic