title: Dietary intake of Curcuma longa and Emblica officinalis increases life span in Drosophila melanogaster.
abstract: Intake of food and nutrition plays a major role in affecting aging process and longevity. However, the precise mechanisms underlying the ageing process are still unclear. To this respect, diet has been considered to be a determinant of ageing process. In order to better illustrate this, we used Drosophila melanogaster as a model and fed them orally with different concentrations of two commonly used Indian medicinal plant products, Curcuma longa (rhizome) and Emblica officinalis (fruit). The results revealed significant increase in life span of Drosophila flies on exposure to both the plant products, more efficiently by C. Longa than by E. officinalis. In order to understand whether the increase in lifespan was due to high-antioxidant properties of these medicinal plants, we performed enzymatic assays to assess the SOD and catalase activities in case of both treated and control Drosophila flies. Interestingly, the results support the free radical theory of aging as both these plant derivatives show high reactive oxygen species (ROS) scavenging activities.
authors: Department of Biotechnology, Jaypee Institute of Information Technology, A-10, Sector-62, Noida, Uttar Pradesh 201307, India.
authors: Shilpa
authors: S
authors: Rawal
authors: Department of Biotechnology, Jaypee Institute of Information Technology, A-10, Sector-62, Noida, Uttar Pradesh 201307, India.
authors: Pavneet
authors: P
authors: Singh
authors: Department of Biotechnology, Jaypee Institute of Information Technology, A-10, Sector-62, Noida, Uttar Pradesh 201307, India.
authors: Ayush
authors: A
authors: Gupta
authors: Department of Biotechnology, Jaypee Institute of Information Technology, A-10, Sector-62, Noida, Uttar Pradesh 201307, India.
authors: Sujata
authors: S
authors: Mohanty
mesh_terms: D000818:Animals; D002374:Catalase / Q000378:metabolism; D030024:Curcuma; D019587:Dietary Supplements; D029721:Drosophila Proteins / Q000378:metabolism; D004331:Drosophila melanogaster; D008136:Longevity / Q000187:drug effects*; D029842:Phyllanthus emblica; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D029721:Drosophila Proteins; D002374:Catalase; D013482:Superoxide Dismutase