title: Initially localized synovial sarcoma in adults: a retrospective single-center analysis of 26 patients registered at the Department of Oncology, University of Vienna between 2004 and 2013.
abstract: BACKGROUND
  Synovial sarcoma is a rare subgroup of all soft-tissue sarcomas. The aim of this retrospective single-center analysis was to investigate the outcome of patients with initially localized disease.
  
  
  METHODS
  Twenty-six patients were enrolled in this retrospective single-center analysis. Baseline characteristics, treatment and outcome were evaluated.
  
  
  RESULTS
  In 13 patients (50%), the tumor was located in the lower extremity and in 4 patients (15%) in the upper extremity. Surgical resection was done in all but 2 patients (92%). Re-resection was done in 7 patients (27%). Fourteen patients (54%) received adjuvant chemotherapy. After a median follow-up of 23.3 months (range: 2.6-150.3), median disease-free survival was not reached at the time of analysis. Eight patients (31%) relapsed after initial therapy. Surgery was done in 2 patients, amputation in 1 patient, palliative chemotherapy was administered in 3 and radiation therapy in 2 patients. Median overall survival (OS) for all patients was not reached at the time of analysis. The estimated 5-year OS rate was 62%.
  
  
  CONCLUSIONS
  Patients with initially localized synovial sarcoma who were included in this retrospective single-center analysis have an estimated 5-year OS rate of 62%.
authors: Clinical Division of Oncology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.
authors: Wolfgang
authors: W
authors: Lamm
authors: Sophie
authors: S
authors: Schur
authors: Wolfgang J
authors: WJ
authors: Köstler
authors: Gabriele
authors: G
authors: Amann
authors: Boris
authors: B
authors: Pokrajac
authors: Philipp
authors: P
authors: Funovics
authors: Joannis
authors: J
authors: Panotopoulos
authors: Thomas
authors: T
authors: Brodowicz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001317:Austria; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000517:prevention & control*; D011379:Prognosis; D012189:Retrospective Studies; D013584:Sarcoma, Synovial / Q000401:mortality / Q000628:therapy*; D012983:Soft Tissue Neoplasms / Q000401:mortality / Q000628:therapy*; D016896:Treatment Outcome; D055815:Young Adult