title: TH17- and IL-17- mediated autoantibodies and placental oxidative stress play a role in the pathophysiology of pre-eclampsia.
abstract: Pre-eclampsia is a multisystem disorder of pregnancy that affects 5-8% of pregnancies. The pathophysiologic mechanisms that lead to the development of pre-eclampsia are poorly understood. Higher than normal levels of circulating TH17 is observed in preeclamptic women compared to women with normal pregnancy. TH17 cells are a subset of CD4+ T helper cells that are characterized by their secretion of IL-17. Recent studies suggest a role for TH17 cells and IL-17 in the pathophysiology of pre-eclampsia. In this review, we will discuss the known function of TH17 cells and IL-17 in immunity and vascular function. We will then review the role of IL-17 and TH17 cells in normal pregnancy and their association with pre-eclampsia, followed by a discussion of the literature to examine a potential role for IL-17 and TH17 cells in mediating pathophysiology in pre-eclampsia.
authors: Department of Pharmacology and Obstetrics and Gynecology University of Mississippi Medical Center Jackson, MS, USA - bblamarca@umc.edu.
authors: D C
authors: DC
authors: Cornelius
authors: B
authors: B
authors: Lamarca
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology; D018384:Oxidative Stress; D010920:Placenta / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000276:immunology / Q000503:physiopathology*; D011247:Pregnancy; D058504:Th17 Cells / Q000276:immunology
chemical_list: D001323:Autoantibodies; D020381:Interleukin-17