title: Palladium catalyzed intramolecular acylcyanation of alkenes using α-iminonitriles.
abstract: Reported here is a palladium catalyzed intramolecular acylcyanation of alkenes using α-iminonitriles. Through this method, highly functionalized indanones are synthesized in moderate to high yields using Pd(PPh3)4, without need for any additional ligands, and a common Lewis acid (ZnCl2). Additionally, the reaction tolerates substitution at various positions on the aromatic ring including electron donating and electron withdrawing groups.
authors: Department of Chemistry, University of Minnesota, 207 Pleasant Street, SE, Minneapolis, Minnesota 55455, USA. cdouglas@umn.edu.
authors: Naveen R
authors: NR
authors: Rondla
authors: Jodi M
authors: JM
authors: Ogilvie
authors: Zhongda
authors: Z
authors: Pan
authors: Christopher J
authors: CJ
authors: Douglas
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D002712:Chlorides / Q000737:chemistry; D009570:Nitriles / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D017967:Zinc Compounds / Q000737:chemistry
chemical_list: D000475:Alkenes; D002712:Chlorides; D009570:Nitriles; D017967:Zinc Compounds; D010165:Palladium; C016837:zinc chloride