title: Multicenter study on the long-term (3-year) efficacy of lanthanum carbonate in dialysis patients.
abstract: We previously conducted a multicenter study enrolling 101 dialysis patients with hyperphosphatemia in which lanthanum carbonate (LC) was administered for 2 years. In this study, the administration has been continued for an additional year, and we have evaluated the long-term (a total of 3 years) effects of LC. The average serum phosphorus (P) level was 6.05 mg/dL at the start and decreased to 5.84 mg/dL after 3 years, but no significant differences were observed at both points. The average serum corrected calcium (Ca) level significantly reduced after 3 years (P < 0.001). As results of evaluating the achievement rates with the management target values of serum P, Ca and intact parathyroid hormone (PTH) stated in the Japanese guideline, the achievement rates increased after 3 years. From these results, LC is considered to be a useful P binder that can be used for long-term treatment of hyperphosphatemia, without causing a Ca load.
authors: Department of Nephrology, Musashino Red Cross Hospital, Tokyo, Japan.
authors: Ryoichi
authors: R
authors: Ando
authors: Satomi
authors: S
authors: Yama
authors: Tsuyoshi
authors: T
authors: Ohnishi
authors: Shunsuke
authors: S
authors: Iwamoto
authors: Hitoshi
authors: H
authors: Kimura
authors: Yoshiko
authors: Y
authors: Chida
authors: Yuji
authors: Y
authors: Ishida
authors: Kouei
authors: K
authors: Yamada
authors: Yuichiro
authors: Y
authors: Inagaki
authors: Masanobu
authors: M
authors: Takayama
authors: Ken
authors: K
authors: Tachibana
authors: Kan
authors: K
authors: Kikuchi
authors: Atsushi
authors: A
authors: Inoue
authors: Masakazu
authors: M
authors: Ohtsuka
mesh_terms: D000368:Aged; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D054559:Hyperphosphatemia / Q000188:drug therapy* / Q000209:etiology; D007676:Kidney Failure, Chronic / Q000628:therapy*; D007811:Lanthanum / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D010758:Phosphorus / Q000097:blood; D006435:Renal Dialysis / Q000379:methods*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D010281:Parathyroid Hormone; D010758:Phosphorus; C119467:lanthanum carbonate; D007811:Lanthanum; D002118:Calcium
keywords: Lanthanum Carbonate; Long-Term Effects; Management Target Values; Multicenter Study