title: Values of troponin T and myoglobin predictive of non-cardiac ischemia in rats.
abstract: OBJECTIVE
  Biochemical markers are important for the timely diagnosis and follow-up of ischemic events. Most of the markers have been previously studied in the context of cardiac ischemia. However, research on markers of non-cardiac events has been insufficient. Therefore, we investigated the relationship between troponin and myoglobin which are commonly used markers of cardiac ischemia, in non-cardiac ischemia.
  
  
  METHODS
  Forty-eight rats were equally divided into six groups. Group I was the control group. Group II was the sham group and received a simple laparotomy. The superior mesenteric artery was clamped in groups III and IV in order to create mesenteric ischemia. The left femoral artery was clamped in groups V and VI in order to create peripheral ischemia. Intracardiac blood samples were taken from all groups (during the 3(rd) hour of ischemia in groups III and V and the 6(th) hour of ischemia in group IV and VI) and troponin T and myoglobin levels were measured.
  
  
  RESULTS
  Troponin and myoglobin levels were statistically similar in groups I and II. Moreover, increments were detected for troponin and myoglobin in ischemia groups according to group I and II. Furthermore, higher troponin Tlevels were detected after three hours of mesenteric ischemia and higher myoglobin values were observed after six hours of mesenteric ischemia (P<0.05).
  
  
  CONCLUSIONS
  Troponin T and myoglobin are not specific for non-cardiac ischemia, and they may be useful for detecting other ischemic events.
authors: Medical School of Dicle University, Department of Cardiovascular Surgery, Diyarbakir, Turkey.
authors: Orkut
authors: O
authors: Guclu
authors: Medical School of Dicle University, Department of Cardiovascular Surgery, Diyarbakir, Turkey.
authors: Ahmet
authors: A
authors: Caliskan
authors: Medical School of Dicle University, Department of Cardiovascular Surgery, Diyarbakir, Turkey.
authors: Oguz
authors: O
authors: Karahan
authors: Medical School of Dicle University, Department of Cardiovascular Surgery, Diyarbakir, Turkey.
authors: Sinan
authors: S
authors: Demirtas
authors: Medical School of Dicle University, Department of Cardiovascular Surgery, Diyarbakir, Turkey.
authors: Suleyman
authors: S
authors: Yazici
authors: Medical School of Dicle University, Department of Cardiovascular Surgery, Diyarbakir, Turkey.
authors: Celal
authors: C
authors: Yavuz
authors: Medical School of Dicle University, Department of Cardiovascular Surgery, Diyarbakir, Turkey.
authors: Binali
authors: B
authors: Mavitas
keywords: Mesenteric ischemia; Myoglobin; Peripheral ischemia; Troponin T