title: Cost-effectiveness of contemporary vascular closure devices for the prevention of vascular complications after percutaneous coronary interventions in an all-comers PCI population.
abstract: OBJECTIVE
  The present observational case-control study assessed the cost-effectiveness of contemporary vascular closure devices (VCDs) for the prevention of vascular complications in an all-comers transfemoral percutaneous coronary intervention (PCI) population.
  
  
  RESULTS
  A total of 8,292 consecutive PCI patients were enrolled from a single-centre prospective registry from January 2005 to December 2010. VCDs were available from July 2007 and, from that time point, VCDs were implanted in 1,780 of the 5,394 patients (33%). Vascular complications occurred in 221 (2.7%) patients. The use of VCDs was independently associated with a 53% risk reduction (OR 0.47, 95% CI: 0.3-0.7) in vascular complications (3.0% vs. 1.5%) and with a 65% risk reduction (IRR 0.37, 95% CI: 0.32-0.43) in the post-PCI length of hospital stay (LOS) (mean 2.8 vs. 1.5 days). Mainly due to the reduced LOS, the patients with VCDs accrued vascular direct medical costs (VCD, diagnosis and treatment of vascular complications, post-PCI LOS) that were on average 498€ less than those accrued by the non-VCD patients. The cost-effectiveness was present across all vascular risk profiles.
  
  
  CONCLUSIONS
  In this large, all-comers transfemoral PCI population, the use of VCDs was independently associated with a reduction in the rate of vascular complications and the post-PCI length of hospital stay and proved to be cost-saving across all vascular risk profiles.
authors: Department of Cardiology, Antwerp University Hospital, Antwerp, Belgium.
authors: Steven
authors: S
authors: Kerré
authors: Lise
authors: L
authors: Kustermans
authors: Tom
authors: T
authors: Vandendriessche
authors: Johan
authors: J
authors: Bosmans
authors: Steven E
authors: SE
authors: Haine
authors: Hielko
authors: H
authors: Miljoen
authors: Christiaan J
authors: CJ
authors: Vrints
authors: Philippe
authors: P
authors: Beutels
authors: Kristien
authors: K
authors: Wouters
authors: Marc J
authors: MJ
authors: Claeys
mesh_terms: D000368:Aged; D001530:Belgium; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D017046:Cost Savings; D003362:Cost-Benefit Analysis; D005260:Female; D005263:Femoral Artery; D006470:Hemorrhage / Q000191:economics* / Q000517:prevention & control*; D006489:Hemostatic Techniques / Q000191:economics* / Q000295:instrumentation*; D017721:Hospital Costs; D006801:Humans; D007902:Length of Stay / Q000191:economics; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000191:economics* / Q000379:methods; D011677:Punctures; D012042:Registries; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D062666:Vascular Access Devices / Q000191:economics*