title: Memantine in the Treatment of Executive Function Deficits in Adults With ADHD.
abstract: To evaluate the efficacy and safety of memantine hydrochloride as an adjunct to stimulant pharmacotherapy for treating executive function deficits (EFDs) in adults with ADHD.
  
  
  
  This was a 12-week, double-blind, placebo-controlled, randomized clinical trial of memantine added to open-label treatment with stimulant medication. Because of the small sample size, we considered a standardized mean difference (equivalent to effect size) of ≥0.5 and odds ratios ≥2 as indicators of trend improvements.
  
  
  
  Twelve participants received memantine and 14 received a placebo. Trend improvements favoring memantine were observed on Behavior Rating Inventory of Executive Functions-Adult Inhibition and Self-Monitor subscales when compared with Placebo. No significant changes were noted on the Cambridge Neuropsychological Test Automated Battery.
  
  
  
  Among adults with ADHD and EFDs, adjunct treatment with memantine to osmotic release oral system-methylphenidate (OROS-MPH) was associated with improvements in selective areas of executive functioning, supporting the need for further research.
authors: 1 Massachusetts General Hospital, Boston, MA, USA.
authors: Joseph
authors: J
authors: Biederman
authors: 1 Massachusetts General Hospital, Boston, MA, USA.
authors: Ronna
authors: R
authors: Fried
authors: 1 Massachusetts General Hospital, Boston, MA, USA.
authors: Laura
authors: L
authors: Tarko
authors: 1 Massachusetts General Hospital, Boston, MA, USA.
authors: Craig
authors: C
authors: Surman
authors: 1 Massachusetts General Hospital, Boston, MA, USA.
authors: Thomas
authors: T
authors: Spencer
authors: 1 Massachusetts General Hospital, Boston, MA, USA.
authors: Amanda
authors: A
authors: Pope
authors: 1 Massachusetts General Hospital, Boston, MA, USA.
authors: Rebecca
authors: R
authors: Grossman
authors: 1 Massachusetts General Hospital, Boston, MA, USA.
authors: Katie
authors: K
authors: McDermott
authors: 1 Massachusetts General Hospital, Boston, MA, USA.
authors: K Yvonne
authors: KY
authors: Woodworth
authors: 2 State University of New York Upstate Medical University, Syracuse, MA, USA.
authors: Stephen V
authors: SV
authors: Faraone
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy* / Q000523:psychology; D000697:Central Nervous System Stimulants / Q000008:administration & dosage* / Q000009:adverse effects; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D056344:Executive Function / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008559:Memantine / Q000008:administration & dosage* / Q000009:adverse effects; D008774:Methylphenidate / Q000008:administration & dosage / Q000009:adverse effects; D008875:Middle Aged; D009995:Osmosis; D010865:Pilot Projects; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000697:Central Nervous System Stimulants; D003692:Delayed-Action Preparations; D008774:Methylphenidate; D008559:Memantine
keywords: ADHD; adult; adult ADHD treatment; executive function deficits; memantine