title: Insights in Hodgkin Lymphoma angiogenesis.
abstract: Angiogenesis is a hallmark of tumor growth and progression in solid and hematological malignancies. Different cellular components of the tumor microenvironment such as macrophages, mast cells, circulating endothelial cells and angiogenic factors, including vascular endothelial growth factor and its receptors are involved in the maintenance of Hodgkin Lymphoma. In this review article, we highlight relevant literature focusing on the relationships between angiogenesis and Hodgkin Lymphoma as well as discussing anti-angiogenic treatments in this malignancy.
authors: Department of Basic Medical Sciences, Neurosciences, and Sensory Organs, University of Bari Medical School, Bari, Italy.
authors: Christian
authors: C
authors: Marinaccio
authors: Department of Basic Medical Sciences, Neurosciences, and Sensory Organs, University of Bari Medical School, Bari, Italy.
authors: Beatrice
authors: B
authors: Nico
authors: Department of Emergency and Transplantation, Pathology Section, University of Bari Medical School, Bari, Italy.
authors: Eugenio
authors: E
authors: Maiorano
authors: Department of Emergency and Transplantation, Hematology Section, University of Bari Medical School, Bari, Italy.
authors: Giorgina
authors: G
authors: Specchia
authors: Department of Basic Medical Sciences, Neurosciences, and Sensory Organs, University of Bari Medical School, Bari, Italy; National Cancer Institute "Giovanni Paolo II", Bari, Italy. Electronic address: domenico.ribatti@uniba.it.
authors: Domenico
authors: D
authors: Ribatti
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000818:Animals; D056572:Histone Deacetylase Inhibitors / Q000627:therapeutic use; D006689:Hodgkin Disease / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D006801:Humans; D056747:Immunomodulation; D008264:Macrophages / Q000502:physiology; D008407:Mast Cells / Q000502:physiology; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors / Q000276:immunology
chemical_list: D020533:Angiogenesis Inhibitors; D056572:Histone Deacetylase Inhibitors; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A
keywords: Angiogenesis; Anti-angiogenesis; Hodgkin Lymphoma; Tumor microenvironment