title: Cancer research: a hurdle race.
abstract: Cancer research has shifted in recent years from studying intracellular processes (identification of damaged genes and signaling pathways) to extracellular (hierarchy of tumor cells, cell transitions, clone competition) and tissue (interactions of a tumor with its environment) research. But then the next step seems to be logical: studying biochemistry of tumor-bearing organisms (namely, cancer-induced changes in cellular and tissue metabolism leading to the organism's death). These data can help to develop new methods of cancer treatment. This article discusses some of the challenges of contemporary oncology and possible ways to overcome them.
authors: Blokhin Cancer Research Center, Institute of Carcinogenesis, Moscow, 115478, Russia. alicht@mail.ru.
authors: A V
authors: AV
authors: Lichtenstein
mesh_terms: D000906:Antibodies / Q000627:therapeutic use; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D063646:Carcinogenesis; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D012106:Research; D059016:Tumor Microenvironment
chemical_list: D000906:Antibodies; D018906:Antineoplastic Agents, Alkylating