title: A new acoustic method to determine the setting time of calcium sulfate bone cement mixed with antibiotics.
abstract: A new method is described which can be used to determine the setting times of small amounts of high value bone cements. The test was developed to measure how the setting times of a commercially available synthetic calcium sulfate cement (Stimulan, Biocomposites, UK) in two forms (standard and Rapid Cure) varies with the addition of clinically relevant antibiotics. The importance of being able to accurately quantify these setting times is discussed. The results demonstrate that this new method, which is shown to correlate to the Vicat needle, gives reliable and repeatable data with additional benefits expressed in the article. The majority of antibiotics mixed were found to retard the setting reaction of the calcium sulfate cement.
authors: Research Department, Biocomposites Ltd, Keele Science Park, Staffordshire, UK.
authors: J J
authors: JJ
authors: Cooper
authors: M J
authors: MJ
authors: Brayford
authors: P A
authors: PA
authors: Laycock
mesh_terms: D000162:Acoustics; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000737:chemistry*; D001843:Bone Cements / Q000737:chemistry*; D001847:Bone Diseases / Q000188:drug therapy / Q000382:microbiology; D001842:Bone and Bones / Q000187:drug effects; D002133:Calcium Sulfate / Q000737:chemistry*; D016503:Drug Delivery Systems; D006801:Humans; D008422:Materials Testing; D009339:Needles; D011208:Powders; D018461:Soft Tissue Infections / Q000188:drug therapy; D014867:Water / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D001843:Bone Cements; D011208:Powders; C561373:Stimulan; D014867:Water; D002133:Calcium Sulfate