title: Interval between intra-arterial infusion chemotherapy and surgery for locally advanced oral squamous cell carcinoma: impacts on effectiveness of chemotherapy and on overall survival.
abstract: BACKGROUND
  The interval between intra-arterial infusion chemotherapy (IAIC) and surgery was investigated in terms of its effects on survival in patients with locally advanced oral squamous cell carcinoma (OSCC).
  
  
  METHODS
  This retrospective study analyzed 126 patients who had completed treatment modalities for stage IV OSCC. All patients were followed up for 3 years. Kaplan-Meier and Cox regression methods were used to determine how survival was affected by general factors, primary tumor volume, TNM stage, and duration of neoadjuvant chemotherapy.
  
  
  RESULTS
  In 126 patients treated for locally advanced OSCC by preoperative induction IAIC using methotrexate, multivariate analysis of relevant prognostic factors showed that an IAIC duration longer than 90 days was significantly associated with poor prognosis (hazard ratio, 1.77; P = 0.0259).
  
  
  CONCLUSIONS
  Duration of IAIC is a critical factor in the effectiveness of multimodal treatment for locally advanced OSCC. Limiting the induction course to 90 days improves overall survival.
authors: Department of Surgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
authors: Chih-Fung
authors: CF
authors: Wu
authors: Department of Nursing, Min-Hwei Junior College of Health Care Management, Tainan 736, Taiwan.
authors: Chien-Hsing
authors: CH
authors: Lee
authors: Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
authors: Edward
authors: E
authors: Hsi
authors: Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan ; Department of Oral Maxillofacial Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
authors: Chung-Ho
authors: CH
authors: Chen
authors: Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan ; Department of Radiation Oncology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan ; Department of Radiation Oncology, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan ; Department of Radiation Oncology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 801, Taiwan.
authors: Jen-Yang
authors: JY
authors: Tang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000401:mortality / Q000601:surgery*; D002945:Cisplatin / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000379:methods*; D053208:Kaplan-Meier Estimate; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery*; D015999:Multivariate Analysis; D016016:Proportional Hazards Models; D012189:Retrospective Studies
chemical_list: D002945:Cisplatin; D008727:Methotrexate