title: Synthetic K⁺/Cl⁻-selective symporter across a phospholipid membrane.
abstract: Synthetic molecules which selectively transport sodium or potassium chloride across a lipid membrane have been prepared. The salt carriers consist of two heteroditopic binding sites, an anion-binding cavity with three hydrogen bond donors and an azacrown ether for binding an alkali metal cation. The association constants between the carriers and chloride ion have been enhanced by 1 order of the magnitude in the presence of sodium or potassium ion in 10% (v/v) CD3OH/CD3CN, due to the formation of a contact ion-pair between the bound cation and chloride as demonstrated by the single-crystal X-ray structure of a sodium chloride complex. A series of transport experiments have demonstrated that the synthetic molecule functions as a mobile carrier of transporting salts via M(+)/Cl(-) symport. Among alkali metal chlorides, the carrier with an 18-azacrown-6 exhibits a strong selectivity toward potassium chloride, while the carrier with a 15-azacrown-5 displays a moderate selectivity for sodium chloride.
authors: Department of Chemistry, University of Yonsei , Seoul 120-749, Korea.
authors: Jung Ha
authors: JH
authors: Lee
authors: Ji Hyun
authors: JH
authors: Lee
authors: Ye Rin
authors: YR
authors: Choi
authors: Philjae
authors: P
authors: Kang
authors: Moon-Gun
authors: MG
authors: Choi
authors: Kyu-Sung
authors: KS
authors: Jeong
mesh_terms: D043844:Crown Ethers / Q000138:chemical synthesis / Q000737:chemistry*; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure; D010743:Phospholipids / Q000737:chemistry*; D011189:Potassium Chloride / Q000737:chemistry*; D012965:Sodium Chloride / Q000737:chemistry
chemical_list: D043844:Crown Ethers; D010743:Phospholipids; D012965:Sodium Chloride; C015762:18-crown-6; D011189:Potassium Chloride