title: Recurrent hemorrhage caused by type 3 von Willebrand disease in a domestic long-haired cat.
abstract: OBJECTIVE
  To describe a case of spontaneous epistaxis in a cat with type 3 von Willebrand disease (VWD) and detail the successful management of hemorrhagic episodes on 2 occasions.
  
  
  METHODS
  A 3.6 kg, 1-year-old, female mixed-breed domestic long-haired cat presented for spontaneous epistaxis. Hemostasis testing at presentation revealed normal prothrombin and activated partial thromboplastin times, a slightly decreased platelet count of 168 × 10(9) /L [168 × 10(3) /μL] (reference interval 200-500 × 10(9) /L [200-500 × 10(3) /μL]) and prolonged buccal mucosal bleeding time of 168 seconds (reference interval <150 s). Specific activities of coagulation factors VIII, IX, XI, and XII were all within reference intervals. Plasma von Willebrand factor concentration, however, was markedly reduced at <0.1% of normal. These findings are compatible with a diagnosis of severe type 3 VWD. The initial occurrence of epistaxis resolved spontaneously soon after admission; however, the cat required a packed RBC transfusion for blood loss anemia. Desmopressin acetate was administered, but failed to arrest hemorrhage during a second episode of epistaxis 12 months later. The second episode was successfully controlled by transfusion of 6.7 mL/kg feline fresh frozen plasma.
  This is the first description of severe type 3 VWD in a domestic cat and only the second report of VWD in this species. Unlike human beings and primates with type 3 VWD, the affected cat did not have a concomitant deficiency of coagulation factor VIII or consistent prolongation of activated partial thromboplastin time. Clinicians should therefore include VWD in the list of differentials for cats with signs of abnormal hemorrhage and confirm the diagnosis with specific measurement of plasma von Willebrand factor concentration.
authors: Cape Cod Veterinary Specialists, 11 Bourne Bridge Approach, Buzzards Bay, MA, 02532.
authors: Kimberly N
authors: KN
authors: Bebar
authors: Virginia
authors: V
authors: Sinnott
authors: Marjory B
authors: MB
authors: Brooks
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000097:blood / Q000628:therapy*; D002415:Cats; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage; D003937:Diagnosis, Differential; D004844:Epistaxis / Q000150:complications / Q000628:therapy / Q000662:veterinary*; D005260:Female; D006487:Hemostasis; D006490:Hemostatics / Q000008:administration & dosage; D017713:Platelet Transfusion / Q000662:veterinary; D012008:Recurrence; D056729:von Willebrand Disease, Type 3 / Q000150:complications / Q000628:therapy / Q000662:veterinary*; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D006490:Hemostatics; D014841:von Willebrand Factor; D003894:Deamino Arginine Vasopressin
keywords: bleeding; epistaxis; feline; inherited coagulopathy