title: Visible-light-promoted redox neutral C-H amidation of heteroarenes with hydroxylamine derivatives.
abstract: A room temperature redox neutral direct C-H amidation of heteroarenes has been achieved. Hydroxylamine derivatives, which are easily accessed, have been employed as tunable nitrogen sources. These reactions were enabled by a visible-light-promoted single-electron transfer pathway without a directing group. A variety of heteroarenes, such as indoles, pyrroles, and furans, could go through this amidation with high yields (up to 98%). These reactions are highly regioselective, and all the products were isolated as a single regioisomer.
authors: State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing 210093, China.
authors: Qixue
authors: Q
authors: Qin
authors: Shouyun
authors: S
authors: Yu
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D005663:Furans / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D006898:Hydroxylamines / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D008027:Light; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry; D010084:Oxidation-Reduction; D011758:Pyrroles / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000577:Amides; D005663:Furans; D006571:Heterocyclic Compounds; D006898:Hydroxylamines; D007211:Indoles; D011758:Pyrroles; D009584:Nitrogen