title: The spatiotemporal cellular dynamics of lung immunity.
abstract: The lung is a complex structure that is interdigitated with immune cells. Understanding the 4D process of normal and defective lung function and immunity has been a centuries-old problem. Challenges intrinsic to the lung have limited adequate microscopic evaluation of its cellular dynamics in real time, until recently. Because of emerging technologies, we now recognize alveolar-to-airway transport of inhaled antigen. We understand the nature of neutrophil entry during lung injury and are learning more about cellular interactions during inflammatory states. Insights are also accumulating in lung development and the metastatic niche of the lung. Here we assess the developing technology of lung imaging, its merits for studies of pathophysiology and areas where further advances are needed.
authors: Department of Pediatrics, University of California-San Francisco, 513 Parnassus Avenue, HSW 518, San Francisco, CA 94143-0511, USA; Department of Pathology, University of California-San Francisco, 513 Parnassus Avenue, HSW 518, San Francisco, CA 94143-0511, USA.
authors: Efrat
authors: E
authors: Lelkes
authors: Department of Pathology, University of California-San Francisco, 513 Parnassus Avenue, HSW 518, San Francisco, CA 94143-0511, USA.
authors: Mark B
authors: MB
authors: Headley
authors: Department of Pathology, University of California-San Francisco, 513 Parnassus Avenue, HSW 518, San Francisco, CA 94143-0511, USA.
authors: Emily E
authors: EE
authors: Thornton
authors: Department of Medicine, University of California-San Francisco, 513 Parnassus Avenue, HSE 1355A, San Francisco, CA 94143-0511, USA.
authors: Mark R
authors: MR
authors: Looney
authors: Department of Pathology, University of California-San Francisco, 513 Parnassus Avenue, HSW 518, San Francisco, CA 94143-0511, USA. Electronic address: Matthew.Krummel@ucsf.edu.
authors: Matthew F
authors: MF
authors: Krummel
mesh_terms: D000818:Animals; D002450:Cell Communication; D006801:Humans; D021621:Imaging, Three-Dimensional; D007249:Inflammation / Q000276:immunology; D008168:Lung / Q000276:immunology* / Q000473:pathology; D008175:Lung Neoplasms / Q000276:immunology*; D038081:Organogenesis