title: Immunoglobulin genes influence the magnitude of humoral immunity to cytomegalovirus glycoprotein B.
abstract: Human cytomegalovirus (HCMV) is a risk factor for many human diseases, but among exposed individuals, not everyone is equally likely to develop HCMV-spurred diseases, implying the presence of host genetic factors that might modulate immunity to this virus. Here, we show that antibody responsiveness to HCMV glycoprotein B (gB) is significantly associated with particular immunoglobulin GM (γ marker) genotypes. Anti-HCMV gB antibody levels were highest in GM 17/17 homozygotes, intermediate in GM 3/17 heterozygotes, and lowest in GM 3/3 homozygotes (28.2, 19.0, and 8.1 µg/mL, respectively; P=.014). These findings provide mechanistic insights in the etiopathogenesis of HCMV-spurred diseases.
authors: Department of Microbiology and Immunology.
authors: Janardan P
authors: JP
authors: Pandey
authors: Department of Public Health Sciences, Medical University of South Carolina, Charleston.
authors: Emily
authors: E
authors: Kistner-Griffin
authors: Department of Microbiology and Immunology.
authors: Faisal F
authors: FF
authors: Radwan
authors: Department of Microbiology and Immunology.
authors: Navtej
authors: N
authors: Kaur
authors: Department of Microbiology and Immunology.
authors: Aryan M
authors: AM
authors: Namboodiri
authors: Department of Microbiology and Immunology.
authors: Laurel
authors: L
authors: Black
authors: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio.
authors: Mary Ann
authors: MA
authors: Butler
authors: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio.
authors: Tania
authors: T
authors: Carreón
authors: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio.
authors: Avima M
authors: AM
authors: Ruder
mesh_terms: D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D016022:Case-Control Studies; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000235:genetics* / Q000276:immunology*; D005803:Genes, Immunoglobulin; D005838:Genotype; D006801:Humans; D056724:Immunity, Humoral; D007126:Immunoglobulin Allotypes / Q000235:genetics / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D014759:Viral Envelope Proteins / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D007126:Immunoglobulin Allotypes; D007074:Immunoglobulin G; D014759:Viral Envelope Proteins; C040495:glycoprotein B, Simplexvirus
keywords: GM allotypes; candidate genes; glycoprotein B; human cytomegalovirus; humoral immunity