title: Formulation and In Vitro Evaluation of Ofloxacin Tablets using Natural Gums as Binders.
abstract: Natural gums are economical, easily available, and useful as tablet binders. In the present investigation, an attempt was made to formulate Ofloxacin tablets using three natural binders, namely Acacia arabica, Hibiscus esculentus, and xanthan gum. Such six batches of Ofloxacin tablets were prepared by using different types and amounts of the natural binders by the wet granulation method. The tablets were analyzed for their hardness, friability, and weight variation, and in vitro release was performed in a phosphate buffer at pH 6.8. The prepared tablets were also evaluated for their various release kinetics and similarity factors f2. The physical properties of the tablets containing the natural binders showed sufficient hardness, desirable disintegration time, and low friability. Their better percentage of drug release was observed as compared to the marketed formulation showing more than 85% drug release within 45 minutes. The in vitro release data was well-fitted into zero-order and the values of release exponent 'n' were between 0.303 and 0.514. The high similarity factor f2 of 64.50 was achieved with the best batch in comparison to the marketed tablets. The results obtained indicated that the gum Acacia arabica performed as well as gelatin compared to the other binders for the Ofloxacin tablet formulation.
authors: Ashok & Rita Patel Institute of Integrated Study & Research in Biotechnology and Allied Sciences, New Vallabh Vidyanagar-388120, Affiliated to Sardar Patel University, Vallabh Vidyanagar-388120, India.
authors: Amisha K
authors: AK
authors: Mistry
authors: Indukaka Ipcowala College of Pharmacy, New Vallabh Vidyanagar-388315, India.
authors: Chirag D
authors: CD
authors: Nagda
authors: A. R. College of Pharmacy & G. H. Patel Institute of Pharmacy, Vallabh Vidyanagar-388120, India.
authors: Dhruti C
authors: DC
authors: Nagda
authors: Chemistry Department, V. P. & R. P. T. P. Science College, Vallabh Vidyanagar-388120, India.
authors: Bharat C
authors: BC
authors: Dixit
authors: Ashok & Rita Patel Institute of Integrated Study & Research in Biotechnology and Allied Sciences, New Vallabh Vidyanagar-388120, Affiliated to Sardar Patel University, Vallabh Vidyanagar-388120, India.
authors: Ritu B
authors: RB
authors: Dixit
keywords: Natural binders; Physico-chemical parameters; Release kinetics; Similarity factor; Tablet