title: Maternal serum anti-Müllerian hormone at 11-13 weeks' gestation in the prediction of preeclampsia.
abstract: OBJECTIVE
  To investigate the potential value of maternal serum anti-Müllerian hormone (AMH) at 11-13 weeks' gestation in the prediction of preeclampsia (PE).
  
  
  METHODS
  The serum concentration of AMH was measured at 11-13 weeks' gestation in cases of PE (n = 50) and normotensive controls (n = 150). Backward stepwise multiple regression analysis was used to determine which of the factors amongst the maternal characteristics and gestation were significant predictors of the serum AMH in the control group and from the regression model the value in each case and control was expressed as a multiple of the expected median (MoM).
  
  
  RESULTS
  In normotensive pregnancies, the maternal serum concentration of AMH is higher in Afro-Caribbean than in Caucasian women and in smokers than in non-smokers. In the PE group, the median serum concentration of AMH was significantly higher than in the controls (2.140 ng/L, IQR 1.968-2.273 versus 2.062 ng/L, IQR 1.938-2.181; p = 0.025), but the median MoM value of AMH was not significantly different between the PE group and the controls (1.040, IQR 0.941-1.081 versus 0.995, IQR 0.939-1.065, p = 0.147).
  
  
  CONCLUSIONS
  Maternal serum AMH is not an effective early predictor for PE.
authors: Harris Birthright Research Centre for Fetal Medicine, King's College Hospital , London , UK and.
authors: Cahit
authors: C
authors: Birdir
authors: Janina
authors: J
authors: Fryze
authors: Haralambos
authors: H
authors: Vasiliadis
authors: Kypros H
authors: KH
authors: Nicolaides
authors: Leona C
authors: LC
authors: Poon
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis*; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood*; D011446:Prospective Studies; D012044:Regression Analysis
chemical_list: D015415:Biomarkers; D054304:Anti-Mullerian Hormone
keywords: AMH; fetal; preeclampsia