title: The effects of carbon nanotubes on lung and dermal cellular behaviors.
abstract: Carbon nanotubes (CNTs) hold great promise to create new and better products, but their adverse health effect is a major concern. Human exposure to CNTs is primarily through inhalation and dermal contact, especially during the manufacturing and handling processes. Numerous animal studies have demonstrated the potential pulmonary and dermal hazards associated with CNT exposure, while in vitro studies have assessed the effects of CNT exposure on various cellular behaviors and have been used to perform mechanistic studies. In this review, we provide an overview of the pathological effects of CNTs and examine the acute and chronic effects of CNT exposure on lung and dermal cellular behaviors, beyond the generally discussed cytotoxicity. We then examine the linkage of cellular behaviors and disease pathogenesis, and discuss the pertinent mechanisms.
authors: Pharmaceutical & Pharmacological Sciences Program, West Virginia University, WV 26506, USA.
authors: Sudjit
authors: S
authors: Luanpitpong
authors: Liying
authors: L
authors: Wang
authors: Yon
authors: Y
authors: Rojanasakul
mesh_terms: D000818:Animals; D002273:Carcinogens / Q000633:toxicity; D006801:Humans; D007249:Inflammation / Q000139:chemically induced / Q000473:pathology; D008168:Lung / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology*; D009153:Mutagens / Q000633:toxicity; D037742:Nanotubes, Carbon / Q000633:toxicity*; D009389:Neovascularization, Pathologic / Q000139:chemically induced / Q000473:pathology; D012867:Skin / Q000187:drug effects* / Q000473:pathology*
chemical_list: D002273:Carcinogens; D009153:Mutagens; D037742:Nanotubes, Carbon
keywords: angiogenesis; carbon nanotubes; carcinogenicity; cellular behavior; cytotoxicity; dermal exposure; genotoxicity; inflammation; lung fibrosis; pulmonary exposure