title: Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
abstract: The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ∼8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD.
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authors: Dan E
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authors: Arking
authors: 1] Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA. [2] Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. [3] Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands. [4].
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authors: Pim
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authors: 1] Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. [2] Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA. [3] Harvard Medical School, Boston, Massachusetts, USA.
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authors: 1] Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA. [2] Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. [3] Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
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authors: J Gustav
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authors: Department of Medicine, University of Helsinki, Helsinki, Finland.
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authors: Markus
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authors: Kimmo
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authors: Department of Cardiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany.
authors: Raimund
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authors: Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany.
authors: Karl-Heinz
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authors: Department of Cardiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany.
authors: Hagen
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authors: Dag S
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authors: Institute of Genetic Epidemiology, Helmholtz Zentrum Munich-German Research Center for Environmental Health, Neuherberg, Germany.
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authors: Thomas
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authors: Institute for Biological and Medical Imaging, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
authors: Siegfried
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authors: Annette
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authors: Department of Medicine I, University Hospital Munich, Ludwig Maximilians Universität, Munich, Germany.
authors: Moritz F
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authors: Sinner
authors: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
authors: Melanie
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authors: Waldenberger
authors: Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors: Rudolf A
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authors: de Boer
authors: Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors: Lude
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authors: Franke
authors: 1] Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. [2] Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors: Pieter A
authors: PA
authors: van der Vleuten
authors: Department of Medicine I, University Hospital Munich, Ludwig Maximilians Universität, Munich, Germany.
authors: Britt Maria
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authors: Beckmann
authors: 1] Department of Medicine I, University Hospital Munich, Ludwig Maximilians Universität, Munich, Germany. [2] Department of Medicine, Hospital of Friedberg, Friedberg, Germany.
authors: Eimo
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authors: Martens
authors: Heart Failure Research Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands.
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authors: Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands.
authors: Nynke
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authors: Hofman
authors: 1] Heart Failure Research Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands. [2] Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders, Jeddah, Saudi Arabia.
authors: Arthur A M
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authors: Wilde
authors: Cardiovascular and Cell Sciences Institute, St George's University of London, London, UK.
authors: Elijah R
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authors: Behr
authors: Biomedical Sciences, St George's University of London, London, UK.
authors: Chrysoula
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authors: Dalageorgou
authors: Windland Smith Rice Sudden Death Genomics Laboratory, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USA.
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authors: 0000000158710265
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authors: Windland Smith Rice Sudden Death Genomics Laboratory, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USA.
authors: Argelia
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authors: Institut du Thorax, INSERM UMR1087, CNRS UMR 6291, Université de Nantes, Nantes, France.
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authors: Barc
authors: 1] Institut du Thorax, Centre Hospitalier Universitaire de Nantes, Université de Nantes, Nantes, France. [2] Institut du Thorax, INSERM UMR1087, CNRS UMR 6291, Université de Nantes, Nantes, France.
authors: Florence
authors: F
authors: Kyndt
authors: 1] Institut du Thorax, Centre Hospitalier Universitaire de Nantes, Université de Nantes, Nantes, France. [2] Institut du Thorax, INSERM UMR1087, CNRS UMR 6291, Université de Nantes, Nantes, France.
authors: Vincent
authors: V
authors: Probst
authors: 1] Department of Molecular Medicine, Section of Cardiology, University of Pavia, Pavia, Italy. [2] Center for Cardiac Arrhythmias of Genetic Origin, Istituto di Ricerca e Cura a Carattere Scientifico Istituto Auxologico Italiano, Milan, Italy.
authors: Alice
authors: A
authors: Ghidoni
authors: 1] Department of Molecular Medicine, Section of Cardiology, University of Pavia, Pavia, Italy. [2] Center for Cardiac Arrhythmias of Genetic Origin, Istituto di Ricerca e Cura a Carattere Scientifico Istituto Auxologico Italiano, Milan, Italy.
authors: Roberto
authors: R
authors: Insolia
authors: 1] The Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. [2] Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada.
authors: Robert M
authors: RM
authors: Hamilton
authors: The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.
authors: Stephen W
authors: SW
authors: Scherer
authors: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors: Jeffrey
authors: J
authors: Brandimarto
authors: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors: Kenneth
authors: K
authors: Margulies
authors: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors: Christine E
authors: CE
authors: Moravec
authors: Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy (affiliated institute of the University of Lübeck, Lübeck, Germany).
authors: Fabiola
authors: F
authors: del Greco M
authors: Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.
authors: Christian
authors: C
authors: Fuchsberger
authors: 1] Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA. [2] Program for Personalized and Genomic Medicine, University of Maryland, Baltimore, Maryland, USA.
authors: Jeffrey R
authors: JR
authors: O'Connell
authors: BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
authors: Wai K
authors: WK
authors: Lee
authors: General Practice and Primary Care, University of Glasgow, Glasgow, UK.
authors: Graham C M
authors: GC
authors: Watt
authors: Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.
authors: Harry
authors: H
authors: Campbell
authors: Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.
authors: Sarah H
authors: SH
authors: Wild
authors: Biobank PopGen, Institute of Experimental Medicine, Christian Albrechts University of Kiel, Kiel, Germany.
authors: Nour E
authors: NE
authors: El Mokhtari
authors: Department of Internal Medicine III, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany.
authors: Norbert
authors: N
authors: Frey
authors: 1] Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute of The Netherlands-Netherlands Heart Institute, Utrecht, The Netherlands. [2] Department of Cardiology, Division of Heart and Lungs, University Medical Centre Utrecht, Utrecht, The Netherlands. [3] Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, UK.
authors: Folkert W
authors: FW
authors: Asselbergs
authors: Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors: Irene
authors: I
authors: Mateo Leach
authors: Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors: Gerjan
authors: G
authors: Navis
authors: Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors: Maarten P
authors: MP
authors: van den Berg
authors: Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors: Dirk J
authors: DJ
authors: van Veldhuisen
authors: 1] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [2] Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
authors: Manolis
authors: M
authors: Kellis
authors: 1] Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands. [2] Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands.
authors: Bouwe P
authors: BP
authors: Krijthe
authors: 1] Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands. [2] Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands.
authors: Oscar H
authors: OH
authors: Franco
authors: 1] Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands. [2] Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands.
authors: Albert
authors: A
authors: Hofman
authors: Department of Medical Informatics, Erasmus Medical Center, Rotterdam, The Netherlands.
authors: Jan A
authors: JA
authors: Kors
authors: 1] Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands. [2] Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands. [3] Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
authors: André G
authors: AG
authors: Uitterlinden
authors: 1] Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands. [2] Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands.
authors: Jacqueline C M
authors: JC
authors: Witteman
authors: First Department of Internal Medicine, Paracelsus Medical University/Salzburger Landeskliniken, Salzburg, Austria.
authors: Lyudmyla
authors: L
authors: Kedenko
authors: Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria.
authors: Claudia
authors: C
authors: Lamina
authors: Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
authors: Ben A
authors: BA
authors: Oostra
authors: Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.
authors: Gonçalo R
authors: GR
authors: Abecasis
authors: Laboratory of Cardiovascular Sciences, Human Cardiovascular Studies Unit, National Institute on Aging, US National Institutes of Health, Baltimore, Maryland, USA.
authors: Edward G
authors: EG
authors: Lakatta
authors: Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy.
authors: Antonella
authors: A
authors: Mulas
authors: Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy.
authors: Marco
authors: M
authors: Orrú
authors: Laboratory of Genetics, Intramural Research Program, National Institute on Aging, US National Institutes of Health, Baltimore, Maryland, USA.
authors: David
authors: D
authors: Schlessinger
authors: Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy.
authors: Manuela
authors: M
authors: Uda
authors: Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
authors: Marcello R P
authors: MR
authors: Markus
authors: 1] DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany. [2] Interfaculty Institute for Genetics and Functional Genomics, Ernst Moritz Arndt University Greifswald, Greifswald, Germany.
authors: Uwe
authors: U
authors: Völker
authors: Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors: Harold
authors: H
authors: Snieder
authors: Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
authors: Timothy D
authors: TD
authors: Spector
authors: 1] Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden. [2] School of Health and Social Sciences, Dalarna University, Falun, Sweden.
authors: Johan
authors: J
authors: Ärnlöv
authors: Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
authors: Lars
authors: L
authors: Lind
authors: Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
authors: Johan
authors: J
authors: Sundström
authors: Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
authors: Ann-Christine
authors: AC
authors: Syvänen
authors: Institute of Cardiovascular Science, University College London, London, UK.
authors: Mika
authors: M
authors: Kivimaki
authors: Department of Clinical Physiology, Tampere University Hospital and University of Tampere School of Medicine, Tampere, Finland.
authors: Mika
authors: M
authors: Kähönen
authors: Department of Clinical Chemistry, Fimlab Laboratories and University of Tampere School of Medicine, Tampere, Finland.
authors: Nina
authors: N
authors: Mononen
authors: 1] Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland. [2] Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
authors: Olli T
authors: OT
authors: Raitakari
authors: Department of Medicine, Turku University Hospital and University of Turku, Turku, Finland.
authors: Jorma S
authors: JS
authors: Viikari
authors: Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
authors: Vera
authors: V
authors: Adamkova
authors: Department of Neurology, Innsbruck Medical University, Innsbruck, Austria.
authors: Stefan
authors: S
authors: Kiechl
authors: 1] Grupo de Medicina Xenómica, Centro Nacional de Genotipado, Centro de Investigación Biomédica en Red de Enfermedades Raras, Universidade de Santiago de Compostela, Santiago de Compostela, Spain. [2] Xenética de Enfermidades Cardiovasculares e Oftalmolóxicas, Complexo Hospitalario Universitario de Santiago de Compostela, Servicio Galego de Saude, Santiago de Compostela, Spain.
authors: Maria
authors: M
authors: Brion
authors: 1] Cyprus Cardiovascular and Educational Research Trust, Nicosia, Cyprus. [2] Vascular Screening and Diagnostic Centre, London, UK.
authors: Andrew N
authors: AN
authors: Nicolaides
authors: First Department of Internal Medicine, Paracelsus Medical University/Salzburger Landeskliniken, Salzburg, Austria.
authors: Bernhard
authors: B
authors: Paulweber
authors: Institute of Medical Epidemiology, Biostatistics and Informatics, Martin Luther University Halle-Wittenberg, Halle, Germany.
authors: Johannes
authors: J
authors: Haerting
authors: BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
authors: Anna F
authors: AF
authors: Dominiczak
authors: 1] Department of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. [2] Global Epidemiology, AstraZeneca Research and Development, Mölndal, Sweden.
authors: Fredrik
authors: F
authors: Nyberg
authors: Division of Population Health Sciences and Education, St George's University of London, London, UK.
authors: Peter H
authors: PH
authors: Whincup
authors: Institute of Cardiovascular Science, University College London, London, UK.
authors: Aroon D
authors: AD
authors: Hingorani
authors: 1] Institut du Thorax, Centre Hospitalier Universitaire de Nantes, Université de Nantes, Nantes, France. [2] Institut du Thorax, INSERM UMR1087, CNRS UMR 6291, Université de Nantes, Nantes, France.
authors: Jean-Jacques
authors: JJ
authors: Schott
authors: Heart Failure Research Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands.
authors: Connie R
authors: CR
authors: Bezzina
authors: 1] Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden. [2] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
authors: Erik
authors: E
authors: Ingelsson
authors: Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, USA.
authors: Luigi
authors: L
authors: Ferrucci
authors: 1] Institute for Maternal and Child Health, "Burlo Garofolo" Trieste, Trieste, Italy. [2] Clinical Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
authors: Paolo
authors: P
authors: Gasparini
authors: Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.
authors: James F
authors: JF
authors: Wilson
authors: Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.
authors: Igor
authors: 0000000169936884
authors: I
authors: Rudan
authors: Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.
authors: Andre
authors: A
authors: Franke
authors: 1] Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany. [2] Institute of Human Genetics, University of Bonn, Bonn, Germany. [3] Institute of Neuroscience and Medicine (INM-1), Structural and Functional Organization of the Brain, Genomic Imaging, Research Centre Juelich, Juelich, Germany.
authors: Thomas W
authors: TW
authors: Mühleisen
authors: 1] Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy (affiliated institute of the University of Lübeck, Lübeck, Germany). [2] Department of Neurology, University of Lübeck, Lübeck, Germany. [3] Department of Neurology, General Central Hospital, Bolzano, Italy.
authors: Peter P
authors: PP
authors: Pramstaller
authors: Department of Clinical Chemistry, Fimlab Laboratories and University of Tampere School of Medicine, Tampere, Finland.
authors: Terho J
authors: TJ
authors: Lehtimäki
authors: Genetics and Genome Biology Program, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
authors: Andrew D
authors: AD
authors: Paterson
authors: 1] Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA. [2] Program for Personalized and Genomic Medicine, University of Maryland, Baltimore, Maryland, USA.
authors: Afshin
authors: A
authors: Parsa
authors: Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University, Winston-Salem, North Carolina, USA.
authors: Yongmei
authors: Y
authors: Liu
authors: Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
authors: Cornelia M
authors: CM
authors: van Duijn
authors: 1] Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA. [2] Department of Epidemiology, University of Washington, Seattle, Washington, USA. [3] Department of Medicine, University of Washington, Seattle, Washington, USA.
authors: David S
authors: DS
authors: Siscovick
authors: 1] Icelandic Heart Association, Kopavogur, Iceland. [2] Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
authors: Vilmundur
authors: V
authors: Gudnason
authors: Human Genetics Research Centre, St George's University of London, London, UK.
authors: Yalda
authors: Y
authors: Jamshidi
authors: Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.
authors: Veikko
authors: V
authors: Salomaa
authors: 1] Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany. [2] DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
authors: Stephan B
authors: SB
authors: Felix
authors: Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy.
authors: Serena
authors: S
authors: Sanna
authors: Center for Systems Genomics, Pennsylvania State University, University Park, Pennsylvania, USA.
authors: Marylyn D
authors: 0000000212081720
authors: MD
authors: Ritchie
authors: 1] Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands. [2] Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands. [3] Department of Medical Informatics, Erasmus Medical Center, Rotterdam, The Netherlands. [4] Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. [5] Inspectorate of Health Care, The Hague, The Netherlands.
authors: Bruno H
authors: BH
authors: Stricker
authors: 1] deCODE genetics, Reykjavik, Iceland. [2] Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
authors: Kari
authors: K
authors: Stefansson
authors: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
authors: Laurie A
authors: LA
authors: Boyer
authors: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors: Thomas P
authors: TP
authors: Cappola
authors: Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
authors: Jesper V
authors: JV
authors: Olsen
authors: 1] Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. [2] Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA. [3] Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark. [4] Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark. [5] Pediatric Surgical Research Laboratories, MassGeneral Hospital for Children, Massachusetts General Hospital, Boston, Massachusetts, USA.
authors: Kasper
authors: K
authors: Lage
authors: Center for Cardiac Arrhythmias of Genetic Origin, Istituto di Ricerca e Cura a Carattere Scientifico Istituto Auxologico Italiano, Milan, Italy.
authors: Peter J
authors: PJ
authors: Schwartz
authors: 1] Department of Medicine I, University Hospital Munich, Ludwig Maximilians Universität, Munich, Germany. [2] DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
authors: Stefan
authors: S
authors: Kääb
authors: Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors: Aravinda
authors: A
authors: Chakravarti
authors: 1] Department of Pediatrics, Division of Pediatric Cardiology, Mayo Clinic, Rochester, Minnesota, USA. [2] Windland Smith Rice Sudden Death Genomics Laboratory, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USA. [3] Department of Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA. [4].
authors: Michael J
authors: MJ
authors: Ackerman
authors: 1] Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy (affiliated institute of the University of Lübeck, Lübeck, Germany). [2] Institute of Human Genetics, Technische Universität München, Munich, Germany. [3] Institute for Bioinformatics and Systems Biology, Helmholtz Zentrum, Munich, Germany. [4].
authors: Arne
authors: A
authors: Pfeufer
authors: 1] Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands. [2] Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. [3].
authors: Paul I W
authors: PI
authors: de Bakker
authors: 1] Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA. [2] Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. [3] Harvard Medical School, Boston, Massachusetts, USA. [4] Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA. [5].
authors: Christopher
authors: C
authors: Newton-Cheh
mesh_terms: D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000235:genetics / Q000378:metabolism; D020013:Calcium Signaling / Q000235:genetics*; D016757:Death, Sudden, Cardiac / Q000209:etiology; D004562:Electrocardiography / Q000379:methods; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000379:methods; D005838:Genotype; D006352:Heart Ventricles / Q000378:metabolism; D006801:Humans; D008133:Long QT Syndrome / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide