title: The roles and regulation of multicellular rosette structures during morphogenesis.
abstract: Multicellular rosettes have recently been appreciated as important cellular intermediates that are observed during the formation of diverse organ systems. These rosettes are polarized, transient epithelial structures that sometimes recapitulate the form of the adult organ. Rosette formation has been studied in various developmental contexts, such as in the zebrafish lateral line primordium, the vertebrate pancreas, the Drosophila epithelium and retina, as well as in the adult neural stem cell niche. These studies have revealed that the cytoskeletal rearrangements responsible for rosette formation appear to be conserved. By contrast, the extracellular cues that trigger these rearrangements in vivo are less well understood and are more diverse. Here, we review recent studies of the genetic regulation and cellular transitions involved in rosette formation. We discuss and compare specific models for rosette formation and highlight outstanding questions in the field.
authors: Department of Cell and Developmental Biology, Oregon Health & Science University, Portland, OR 97239, USA Neuroscience Graduate Program, Oregon Health & Science University, Portland, OR 97239, USA.
authors: Molly J
authors: MJ
authors: Harding
authors: Department of Cell and Developmental Biology, Oregon Health & Science University, Portland, OR 97239, USA.
authors: Hillary F
authors: HF
authors: McGraw
authors: Department of Cell and Developmental Biology, Oregon Health & Science University, Portland, OR 97239, USA nechipor@ohsu.edu.
authors: Alex
authors: A
authors: Nechiporuk
mesh_terms: D000818:Animals; D019521:Body Patterning / Q000502:physiology*; D002448:Cell Adhesion / Q000502:physiology*; D003599:Cytoskeleton / Q000502:physiology; D004331:Drosophila melanogaster; D004847:Epithelial Cells / Q000502:physiology*; D006801:Humans; D007684:Kidney Tubules / Q000196:embryology; D053403:Lateral Line System / Q000196:embryology; D008954:Models, Biological; D009024:Morphogenesis / Q000502:physiology*; D054259:Neural Tube / Q000196:embryology; D010179:Pancreas / Q000196:embryology; D017956:Photoreceptor Cells, Invertebrate / Q000502:physiology; D014982:Xenopus laevis; D015027:Zebrafish
keywords: Drosophila epithelium; Morphogenesis; Myosin II; Rosette; Zebrafish lateral line