title: FEV1 inversely correlates with metalloproteinases 1, 7, 9 and CRP in COPD by biomass smoke exposure.
abstract: BACKGROUND
  Matrix metalloproteinases (MMPs) and C-reactive protein (CRP) are involved in chronic obstructive pulmonary disease (COPD) pathogenesis. The aim of the present work was to determine plasma concentrations of MMPs and CRP in COPD associated to biomass combustion exposure (BE) and tobacco smoking (TS).
  
  
  METHODS
  Pulmonary function tests, plasma levels of MMP-1, MMP-7, MMP-9, MMP-9/TIMP-1 and CRP were measured in COPD associated to BE (n = 40) and TS (n =40) patients, and healthy non-smoking (NS) healthy women (controls, n = 40).
  
  
  RESULTS
  Plasma levels of MMP-1, MMP-7, MMP-9, and MMP-9/TIMP-1 and CRP were higher in BE and TS than in the NS healthy women (p <0.01). An inverse correlation between MMP-1, MMP-7, MMP-9, MMP-9/TIMP-1 and CRP plasma concentrations and FEV1 was observed.
  
  
  CONCLUSIONS
  Increase of MMPs and CRP plasma concentrations in BE suggests a systemic inflammatory phenomenon similar to that observed in COPD associated to tobacco smoking, which may also play a role in COPD pathogenesis.
authors: Martha
authors: M
authors: Montaño
authors: Raul H
authors: RH
authors: Sansores
authors: Carina
authors: C
authors: Becerril
authors: Jose
authors: J
authors: Cisneros
authors: Georgina
authors: G
authors: González-Avila
authors: Bettina
authors: B
authors: Sommer
authors: Leticia
authors: L
authors: Ochoa
authors: Iliana
authors: I
authors: Herrera
authors: Alejandra
authors: A
authors: Ramírez-Venegas
authors: Departamento de Fibrosis Pulmonar, Calzada de Tlalpan 4502, Tlalpan D,F, México, C,P, 14080 México, DF, Mexico. carlos.ramos26@yahoo.com.mx.
authors: Carlos
authors: C
authors: Ramos
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D018533:Biomass; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology*; D005648:Fuel Oils / Q000009:adverse effects; D006801:Humans; D020781:Matrix Metalloproteinase 1 / Q000097:blood*; D020783:Matrix Metalloproteinase 7 / Q000097:blood*; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D012906:Smoke / Q000009:adverse effects; D012907:Smoking / Q000009:adverse effects / Q000097:blood* / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D005648:Fuel Oils; D012906:Smoke; D002097:C-Reactive Protein; C060932:MMP7 protein, human; D020783:Matrix Metalloproteinase 7; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9; C522360:MMP1 protein, human; D020781:Matrix Metalloproteinase 1