title: The influence of endocannabinoid receptor 1 gene variations on anthropometric and metabolic parameters of women with polycystic ovary syndrome.
abstract: BACKGROUND
  Polycystic ovary syndrome (PCOS) is associated with an increasing number of metabolic comorbidities. About 50% of PCOS patients are obese, and insulin resistance affects up to 70% of these women. The endocannabinoid system contributes to human energy homeostasis. CNR1 is a biological candidate for human obesity and related metabolic disorders. The aim of this study was to determine the relationships between CNR1 polymorphisms and anthropometric and metabolic parameters in PCOS women.
  
  
  METHODS
  130 women diagnosed with PCOS according to the Rotterdam criteria were recruited. The control group consisted of 70 healthy women. Medical history was taken, and physical examination as well as assessment of anthropometric (body mass, height, waist and hip circumference, BMI, waist-to-hip ratio [WHR]) and metabolic parameters (glucose and insulin, the insulin resistance index HOMA, lipid profile) was carried out. Genetic studies to detect six CNR1 gene polymorphisms were performed.
  
  
  RESULTS
  The total cholesterol and low-density lipoprotein (LDL) cholesterol levels in PCOS women carrying T/T genotype of rs2023239CNR1 polymorphism were higher than in those with C/T and C/C. There were no statistical differences in other metabolic parameters or in the value of BMI and WHR between the variants of rs2023239 CNR1 polymorphism. The other studied polymorphisms of the CNR1 gene were not associated with anthropometric or metabolic parameters in PCOS women. There were no differences in anthropometric or metabolic parameters between the variants of studied polymorphisms of the CNR1 gene in control women.
  
  
  CONCLUSIONS
  On the basis of our study, it seems that CNR1 polymorphisms are not associated with obesity and metabolic disorders, including insulin resistance, in PCOS women.
authors: agalena0@op.pl.
authors: Agnieszka
authors: A
authors: Lenarcik-Kabza
authors: Łukasz
authors: Ł
authors: Łaczmański
authors: Andrzej
authors: A
authors: Milewicz
authors: Bożena
authors: B
authors: Bidzińska-Speichert
authors: Maurycy
authors: M
authors: Pawlak
authors: Katarzyna
authors: K
authors: Kolackov
authors: Justyna
authors: J
authors: Kuliczkowska-Płaksej
authors: Anna
authors: A
authors: Trzmiel-Bira
authors: Anna
authors: A
authors: Brona
mesh_terms: D000328:Adult; D050218:Body Fat Distribution; D015992:Body Mass Index; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics*; D009765:Obesity / Q000150:complications / Q000235:genetics* / Q000378:metabolism; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D043884:Receptor, Cannabinoid, CB1 / Q000235:genetics*; D044465:White People / Q000235:genetics; D055815:Young Adult
chemical_list: C571130:CNR1 protein, human; D043884:Receptor, Cannabinoid, CB1