title: Toward pH-responsive coating materials--high-throughput study of (meth)acrylic copolymers.
abstract: The release behavior of a model compound (β-naphthol orange) encapsulated in (meth)acrylate-based statistical copolymers under different environmental conditions was investigated. From monomers of varying polarity (methyl acrylate, ethyl acrylate, tert-butyl acrylate, 2-ethylhexyl methacrylate, and benzyl methacrylate) in combination with methacrylic acid, five polymer series were synthesized by free radical polymerization. The pH-dependent release kinetics were investigated via UV-vis spectroscopy at pH 1.2 and 6.8, simulating physiological conditions in the stomach and intestines. Furthermore, the influence of different ethanol contents (0 and 40 vol %) in the acidic medium was investigated. The whole approach was designed to meet the requirements of a high-throughput experimentation workflow.
authors: Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena , Humboldtstr. 10, 07743 Jena, Germany.
authors: Andreas
authors: A
authors: Krieg
authors: Elif
authors: E
authors: Arici
authors: Norbert
authors: N
authors: Windhab
authors: Jan Hendrik
authors: JH
authors: Schattka
authors: Stephanie
authors: S
authors: Schubert
authors: Ulrich S
authors: US
authors: Schubert
mesh_terms: D001391:Azo Compounds / Q000008:administration & dosage*; D001557:Benzenesulfonates / Q000008:administration & dosage*; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000737:chemistry*; D057166:High-Throughput Screening Assays; D006863:Hydrogen-Ion Concentration; D058105:Polymerization; D019904:Polymethyl Methacrylate / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D001391:Azo Compounds; D001557:Benzenesulfonates; D003692:Delayed-Action Preparations; D019904:Polymethyl Methacrylate; C014722:2-naphthol orange