title: Physicochemical properties and in vitro mineralization of porous polymethylmethacrylate cement loaded with calcium phosphate particles.
abstract: The main goal of this study was to evaluate the effects of incorporation of calcium phosphate (CaP) particles on the physicochemical properties and mineralization capacity of cements in vitro. Herein, two different types of CaP particles were loaded into polymethylmethacrylate (PMMA) cements exhibiting an interconnected porosity created by mixing with carboxymethylcellulose. The incorporation of CaP particles did not influence the maximum polymerization temperature of the porous PMMA, but reduced the porosity and the average pore size. Small CaP particles formed agglomerations within the PMMA pores, whereas big CaP particles were partially embedded in the PMMA matrix and partially exposed to the pores. Both types of CaP particles enhanced the mineralization capacity of PMMA cement without compromising their mechanical properties. The data presented herein suggest that porous PMMA/CaP cements hold strong promise for surgical application in bone reconstruction.
authors: The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, People's Republic of China; Department of Biomaterials, Radboud University Medical Center, Nijmegen, The Netherlands.
authors: Yue
authors: Y
authors: Sa
authors: Fang
authors: F
authors: Yang
authors: Sander C G
authors: SC
authors: Leeuwenburgh
authors: Joop G C
authors: JG
authors: Wolke
authors: Guang
authors: G
authors: Ye
authors: Joost R
authors: JR
authors: de Wijn
authors: John A
authors: JA
authors: Jansen
authors: Yining
authors: Y
authors: Wang
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D001843:Bone Cements / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry*; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry; D019245:Compressive Strength; D003460:Crystallization; D055119:Elastic Modulus; D006801:Humans; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D010949:Plasma; D058105:Polymerization; D019904:Polymethyl Methacrylate / Q000737:chemistry*; D016062:Porosity; D012996:Solutions; D013696:Temperature; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D001843:Bone Cements; D002130:Calcium Phosphates; D012996:Solutions; D019904:Polymethyl Methacrylate; C020243:calcium phosphate; D002266:Carboxymethylcellulose Sodium
keywords: calcium phosphate; cement; porous polymethylmethacrylate