title: A genetic variant in SLC6A20 is associated with Type 2 diabetes in white-European and Chinese populations.
abstract: OBJECTIVE
  To investigate whether polymorphisms in SLC6A20 are associated with susceptibility to Type 2 diabetes.
  
  
  METHODS
  In the Rotterdam Study, a prospective, population-based cohort (n = 5974), 22 tagging polymorphisms with minor allele frequencies>0.05 across SLC6A20 were studied. Replication studies were performed in an independent Dutch case-control study (DiaGene-Rotterdam Study 2 n = 3133), and in a Chinese Han case-control population (n = 2279). A meta-analysis of the results was performed.
  
  
  RESULTS
  In the Rotterdam study, the minor alleles of rs13062383, rs10461016 and rs2286489 increased the risk of Type 2 diabetes (hazard ratio 1.37, 95% CI 1.15-1.63, hazard ratio 1.30 95% CI 1.09-1.54 and hazard ratio 1.20, 95% CI 1.07-1.35, respectively). In the DiaGene/Rotterdam Study 2, the A allele of rs13062383 increased the risk of Type 2 diabetes (odds ratio 1.45, 95% CI 1.19-1.76). In the Chinese Han study, the rs13062383 A allele also increased the risk of Type 2 diabetes (odds ratio 1.21, 95% CI 1.03-1.42). Meta-analysis showed a highly significant association of rs13062383 with Type 2 diabetes (odds ratio 1.35, 95% CI 1.21-1.47; P = 3.3 × 10⁻⁸).
  
  
  CONCLUSIONS
  In conclusion, rs13062383 in SLC6A20 increased the susceptibility to Type 2 diabetes in populations with different genetic backgrounds.
authors: Department of Endocrinology and Metabolism, Zhongshan hospital, Fudan University, Shanghai, China.
authors: Y
authors: Y
authors: Ling
authors: T T W
authors: TT
authors: van Herpt
authors: M
authors: M
authors: van Hoek
authors: A
authors: A
authors: Dehghan
authors: A
authors: A
authors: Hofman
authors: A G
authors: AG
authors: Uitterlinden
authors: S
authors: S
authors: Jiang
authors: A G
authors: AG
authors: Lieverse
authors: B
authors: B
authors: Bravenboer
authors: D
authors: D
authors: Lu
authors: C M
authors: CM
authors: van Duijn
authors: X
authors: X
authors: Gao
authors: E J G
authors: EJ
authors: Sijbrands
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People; D016022:Case-Control Studies; D002681:China; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007438:Introns; D008297:Male; D026901:Membrane Transport Proteins / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D009426:Netherlands; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D044465:White People
chemical_list: D026901:Membrane Transport Proteins; C431703:SLC6A20 protein, human