title: EMMPRIN expression in oral squamous cell carcinomas: correlation with tumor proliferation and patient survival.
abstract: The aim of our study was to explore the clinicopathological and prognostic significance of extracellular matrix metalloproteinase inducer (EMMPRIN) expression in oral squamous cell carcinomas (OSCC), and its relation with the proliferative tumor status of OSCC. We examined EMMPRIN and Ki-67 proteins expression by immunohistochemistry in 74 cases with OSCC. Statistical analysis was conducted to examine their clinicopathological and prognostic significance in OSCC. EMMPRIN membrane expression was observed in all cases, with both membrane and cytoplasmic tumor expression in 61 cases (82.4%). EMMPRIN overexpression was observed in 56 cases (75.7%). Moderately or poorly differentiated tumors showed EMMPRIN overexpression more frequently than well-differentiated tumors (P = 0.002). Overexpression of EMMPRIN was correlated with high Ki-67 expression (P = 0.004). In the multivariate analysis, EMMPRIN overexpression reveals an adverse independent prognostic value for cancer-specific survival (CSS) (P = 0.034). Our results reveal that EMMPRIN protein is overexpressed in more than two-thirds of OSCC cases, especially in high proliferative and less differentiated tumors. The independent value of EMMPRIN overexpression in CSS suggests that this protein could be used as an important biological prognostic marker for patients with OSCC. Moreover, the high expression of EMMPRIN makes it a possible therapeutic target in OSCC patients.
authors: Molecular Oncology Group, Institute of Research and Advanced Training in Health Sciences and Technologies (IINFACTS), Higher Institute of Health Sciences, CESPU, 4585-116 Paredes, Portugal ; Medicine and Oral Surgery Department, Higher Institute of Health Sciences, 4585-116 Paredes, Portugal.
authors: Luís Silva
authors: LS
authors: Monteiro
authors: Molecular Oncology Group, Institute of Research and Advanced Training in Health Sciences and Technologies (IINFACTS), Higher Institute of Health Sciences, CESPU, 4585-116 Paredes, Portugal.
authors: Maria Leonor
authors: ML
authors: Delgado
authors: Pathology Department, Higher School of Health of Vale do Sousa, 4585-116 Paredes, Portugal ; Differentiation and Cancer Group, Institute of Molecular Pathology and Immunology of the University of Porto, (IPATIMUP), 4200-465 Porto, Portugal.
authors: Sara
authors: S
authors: Ricardo
authors: Pathology Department, Higher School of Health of Vale do Sousa, 4585-116 Paredes, Portugal.
authors: Fernanda
authors: F
authors: Garcez
authors: Molecular Oncology Group, Institute of Research and Advanced Training in Health Sciences and Technologies (IINFACTS), Higher Institute of Health Sciences, CESPU, 4585-116 Paredes, Portugal ; Medicine and Oral Surgery Department, Higher Institute of Health Sciences, 4585-116 Paredes, Portugal ; Stomatology Department, Santo António Hospital, Oporto Hospitalar Centre, 4099-001 Porto, Portugal.
authors: Barbas
authors: B
authors: do Amaral
authors: Molecular Oncology Group, Institute of Research and Advanced Training in Health Sciences and Technologies (IINFACTS), Higher Institute of Health Sciences, CESPU, 4585-116 Paredes, Portugal ; Medicine and Oral Surgery Department, Higher Institute of Health Sciences, 4585-116 Paredes, Portugal.
authors: José Júlio
authors: JJ
authors: Pacheco
authors: Molecular Pathology and Immunology Department, Institute of Biomedical Sciences Abel Salazar (ICBAS), Porto University, 4050-313 Porto, Portugal.
authors: Carlos
authors: C
authors: Lopes
authors: Molecular Oncology Group, Institute of Research and Advanced Training in Health Sciences and Technologies (IINFACTS), Higher Institute of Health Sciences, CESPU, 4585-116 Paredes, Portugal ; Centro de Química Medicinal da Universidade do Porto (CEQUIMED-UP), Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal ; Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR/CIMAR), Universidade do Porto, Rua dos Bragas 289, 4050-123 Porto, Portugal.
authors: Hassan
authors: 0000-0002-4006-5779
authors: H
authors: Bousbaa
mesh_terms: D000368:Aged; D051926:Basigin / Q000096:biosynthesis*; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D049109:Cell Proliferation; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D015996:Survival Rate
chemical_list: C497886:BSG protein, human; D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D051926:Basigin