title: Hemophagocytic lymphohistiocytosis secondary to T-cell/histiocyte-rich large B-cell lymphoma.
abstract: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening clinical syndrome characterized by dysregulation of the immune system. Impaired function of cytotoxic T cells and natural killer cells is often seen, and T-cell malignancies represent most cases of lymphoma-associated HLH. HLH associated with B-cell lymphoma is rare. We describe a case of a 30-year-old man who presented with fever, splenomegaly, and hyperferritinemia. Bone marrow biopsy revealed T-cell/histiocyte-rich large B-cell lymphoma, a rare, aggressive B-cell malignancy. This case highlights the interplay between a pro-inflammatory cytokine microenvironment and tumor-mediated immune suppression, and addresses the importance of accurately diagnosing these entities for appropriate clinical management.
authors: Department of Pathology UMass Memorial Medical Center and University of Massachusetts Medical School, 1 Innovation Drive, Biotech 3, Worcester, MA 01605, USA.
authors: Katherine
authors: K
authors: Devitt
authors: Department of Hematology/Oncology, UMass Memorial Medical Center and University of Massachusetts Medical School, Worcester, MA 01605, USA.
authors: Jan
authors: J
authors: Cerny
authors: Department of Hematology/Oncology, UMass Memorial Medical Center and University of Massachusetts Medical School, Worcester, MA 01605, USA.
authors: Bradley
authors: B
authors: Switzer
authors: Department of Hematology/Oncology, UMass Memorial Medical Center and University of Massachusetts Medical School, Worcester, MA 01605, USA.
authors: Muthalagu
authors: M
authors: Ramanathan
authors: Department of Hematology/Oncology, UMass Memorial Medical Center and University of Massachusetts Medical School, Worcester, MA 01605, USA.
authors: Rajneesh
authors: R
authors: Nath
authors: Department of Pathology UMass Memorial Medical Center and University of Massachusetts Medical School, 1 Innovation Drive, Biotech 3, Worcester, MA 01605, USA.
authors: Hongbo
authors: H
authors: Yu
authors: Department of Pathology UMass Memorial Medical Center and University of Massachusetts Medical School, 1 Innovation Drive, Biotech 3, Worcester, MA 01605, USA.
authors: Bruce A
authors: BA
authors: Woda
authors: Department of Pathology UMass Memorial Medical Center and University of Massachusetts Medical School, 1 Innovation Drive, Biotech 3, Worcester, MA 01605, USA.
authors: Benjamin J
authors: BJ
authors: Chen
keywords: Chemotherapy; Hemophagocytic lymphohistiocytosis (HLH); Stem cell transplant; T-cell/histiocyte rich large B-cell lymphoma (THRLBCL)