title: A cross talk between codon usage bias in human oncogenes.
abstract: BACKGROUND
  Oncogenes are the genes that have the potential to induce cancer. The extent and origin of codon usage bias is an important indicator of the forces shaping genome evolution in living organisms.
  
  
  RESULTS
  We observed moderate correlations between gene expression as measured by CAI and GC content at any codon site. The findings of our results showed that there is a significant positive correlation (Spearman's r= 0.45, P<0.01) between GC content at first and second codon position with that of third codon position. Further, striking negative correlation (r = -0.771, P < 0.01) between ENC with the GC3s values of each gene and positive correlation (r=0.644, P<0.01) in between CAI and ENC was also observed.
  
  
  CONCLUSIONS
  The mutation pressure is the major determining factor in shaping the codon usage pattern of oncogenes rather than natural selection since its effects are present at all codon positions. The results revealed that codon usage bias determines the level of oncogene expression in human. Highly expressed oncogenes had rich GC contents with high degree of codon usage bias.
authors: Department of Biotechnology, Assam University, Silchar 788011, Assam, India.
authors: Tarikul Huda
authors: TH
authors: Mazumder
authors: Department of Biotechnology, Assam University, Silchar 788011, Assam, India.
authors: Supriyo
authors: S
authors: Chakraborty
authors: Department of Biotechnology, Assam University, Silchar 788011, Assam, India.
authors: Prosenjit
authors: P
authors: Paul
keywords: Codon usage pattern; Oncogene; Synonymous codon