title: Development of three X-linked tetrameric microsatellite markers for forensic purposes.
abstract: In this study, we obtained sequence and population genetic data for three X-linked short tandem repeat markers (X-STRs; DXS7129, DXS2500, G10583). We investigated their population genetics and estimated their forensic parameters in 214 healthy unrelated individuals from the Han population of Northern China (105 males and 109 females). We showed that DXS2500 and G10583 were highly polymorphic and thus have potential for application in forensic medicine. We also estimated the overall linkage disequilibrium between pairs of loci, specific multiallelic or interallelic associations, and haplotype frequencies in males. We showed that the three X-STR loci segregate as stable haplotype blocks; this could be a powerful tool for haplotype analysis in kinship testing.
authors: Department of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory of Forensic Medicine, No. 361 Zhongshan East Road, Shijiazhuang, 050017, People's Republic of China.
authors: Chunnan
authors: C
authors: Dong
authors: Lihong
authors: L
authors: Fu
authors: Xiaojing
authors: X
authors: Zhang
authors: Chunling
authors: C
authors: Ma
authors: Feng
authors: F
authors: Yu
authors: Shujin
authors: S
authors: Li
authors: Bin
authors: B
authors: Cong
mesh_terms: D000483:Alleles; D005260:Female; D053803:Forensic Genetics; D005787:Gene Frequency; D050172:Genes, X-Linked; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats