title: Protein pathway analysis in Clinical Proteomics using protein microarrays.
abstract: Molecular diagnostics research within the field of cancer is increasingly focused on detecting low-abundance protein endpoints that can be used to define a patient's disease more completely. Protein microarrays represent an important Clinical Proteomics tool for directly measuring protein endpoints in samples extracted from patient tissues. By combining laser capture microdissection, arraying devices, validated isoform-specific antibodies and advanced reporter technology tools, Clinical Proteomics laboratories are currently generating molecular portraits of cancer cells harvested from patient biopsies.:
authors: The Center for Applied Proteomics and Molecular Medicine, George Mason University, 10900 University Blvd MS 4E3, Discovery Hall Room 182, Manassas, VA 20110, USA. Electronic address:dgeho@gmu.edu.
authors: David H
authors: DH
authors: Geho
authors: The Center for Applied Proteomics and Molecular Medicine, George Mason University, 10900 University Blvd MS 4E3, Discovery Hall Room 182, Manassas, VA 20110, USA.
authors: Virginia
authors: V
authors: Espina
authors: The Center for Applied Proteomics and Molecular Medicine, George Mason University, 10900 University Blvd MS 4E3, Discovery Hall Room 182, Manassas, VA 20110, USA.
authors: Julia
authors: J
authors: Wulfkuhle
authors: The Center for Applied Proteomics and Molecular Medicine, George Mason University, 10900 University Blvd MS 4E3, Discovery Hall Room 182, Manassas, VA 20110, USA.
authors: Emanuel F
authors: EF
authors: Petricoin
authors: The Center for Applied Proteomics and Molecular Medicine, George Mason University, 10900 University Blvd MS 4E3, Discovery Hall Room 182, Manassas, VA 20110, USA.
authors: Lance A
authors: LA
authors: Liotta