title: In vivo implantation of hydrophobic acrylic intraocular lenses with surface modification.
abstract: OBJECTIVE
  To assess the surface properties of modified hydrophobic acrylic intraocular lenses (IOL) implanted in rabbits.
  
  
  METHODS
  The hydrophobic acrylic IOLs were modified with monomer vinyl pyrrolidone by surface modification technique. Phacoemulsification combined with IOL implantation was conducted in 9 rabbits (18 eyes). Postoperative responses were observed by slit-lamp microscope at 3, 7, 15, 30, 90 days after surgery.
  
  
  RESULTS
  During the early stage after IOL implantation, corneal edema and anterior chamber fibrin exudation were observed. The exudate fluid was almost absorbed at the 15th day postoperatively. At 7th day, the anterior chamber exudation in the modification group was significantly less severe than that in non-modification group (P < 0.05). Posterior capsular opacification occurred at 30th day after surgery and was aggravated 90 days later. IOL dislocation was seen in 5 eyes and occlusion of pupil in 3 eyes.
  
  
  CONCLUSIONS
  The hydrophobic acrylic IOLs with surface modification have improved surface properties and higher uveal biocompatibility.
authors: Guiqin
authors: G
authors: Wang
authors: Liqun
authors: L
authors: Cao
authors: Na
authors: N
authors: Li
authors: Xiujun
authors: X
authors: Peng
authors: Huiqin
authors: H
authors: Tang
authors: Rongxin
authors: R
authors: Wan
authors: Hanqing
authors: H
authors: Gu
mesh_terms: D000818:Animals; D000867:Anterior Chamber; D005122:Exudates and Transudates / Q000378:metabolism; D057927:Hydrophobic and Hydrophilic Interactions; D019654:Lens Implantation, Intraocular / Q000379:methods*; D007910:Lenses, Intraocular; D008422:Materials Testing; D018918:Phacoemulsification / Q000379:methods*; D019904:Polymethyl Methacrylate; D011760:Pyrrolidinones; D011817:Rabbits; D013499:Surface Properties / Q000187:drug effects; D014602:Uvea
chemical_list: D011760:Pyrrolidinones; D019904:Polymethyl Methacrylate