title: Correlation of serum homocysteine levels with the severity of coronary artery disease.
abstract: Coronary artery disease (CAD) has become the most common cause of mortality in the entire world. Homocysteine is implicated as an early atherosclerotic promoter. We studied the relationship between levels of serum homocysteine with severity of coronary artery disease. Total of 70 subjects who scheduled for coronary angiogram consented to participate in this study. In all the patients Gensini scoring system was used to assess the severity of CAD. Venous samples were taken from the patients in fasting state before angiography. Homocysteine levels in patients were measured by enzyme linked immunosorbant method and were compared with respective Genseni scores of participants. Fasting serum homocysteine levels in CAD patients were significantly higher than patients without coronary artery disease (p < 0.001). Also Homocyseine levels correlated significantly with increasing severity of CAD (p < 0.001). Serum homocysteine levels correlated well with the severity of CAD.
authors: Department of Biochemistry, Kasturba Medical College, Manipal University, Manipal, India.
authors: Vijetha
authors: V
authors: Shenoy
authors: Department of Applied Nutrition, Dietics Welcome Group School of Hotel Management, Manipal University, Manipal, India.
authors: Veena
authors: V
authors: Mehendale
authors: Department of Biochemistry, Kasturba Medical College, Manipal University, Manipal, India.
authors: Krishnananda
authors: K
authors: Prabhu
authors: Department of Cardiology, Kasturba Medical College, Manipal University, Manipal, India.
authors: Ranjan
authors: R
authors: Shetty
authors: Department of Biochemistry, Kasturba Medical College, Manipal University, Manipal, India.
authors: Pragna
authors: P
authors: Rao
keywords: Coronary artery disease (CAD); Gensini scoring system; Homocysteine