title: The antitumor activity of a red alga polysaccharide complexes carrying 5-fluorouracil.
abstract: Porphyran is a sulfated galactan isolated from red algae Porphyra haitanensis, and have been reported to have many kinds of biological activities such as antitumor activity. In order to provide a water-soluble macromolecule prodrug of 5-Fu showing slow release of 5-Fu and reducing side-effect, we carried out fixation of 5-Fu to porphyran at 6-position. In this study, the antitumor and immunomodulation activities of low MW porphyran carrying 5-Fu on transplanted S180 tumor mice were studied. Weight of immune organ, proliferation ratio of lymphocyte concentration of TNF-α and NO from the transplanted S180 tumor mice were also determined. Results indicated that the conjugate could enhance antitumor activity of 5-Fu and improve immunocompetence damaged by 5-Fu.
authors: Department of Pharmacology, Huzhou Teachers College, Huzhou 313000, China. Electronic address: wangxiaomei@hutc.zj.cn.
authors: Xiaomei
authors: X
authors: Wang
authors: Department of Pharmacology, Huzhou Teachers College, Huzhou 313000, China.
authors: Zhongshan
authors: Z
authors: Zhang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry*; D005472:Fluorouracil / Q000737:chemistry* / Q000494:pharmacology*; D056747:Immunomodulation / Q000187:drug effects; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D011134:Polysaccharides / Q000737:chemistry*; D044664:Porphyra / Q000737:chemistry*; D013154:Spleen / Q000187:drug effects / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D011134:Polysaccharides; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide; D005472:Fluorouracil
keywords: 5-Fu; Antitumor; Low-molecular-weight porphyran