title: Clinical performance of digital cervicography and cytology for cervical cancer screening in HIV-infected women in Lusaka, Zambia.
abstract: Although there is a growing literature on the clinical performance of visual inspection with acetic acid in HIV-infected women, to the best of our knowledge, none have studied visual inspection with acetic acid enhanced by digital cervicography. We estimated clinical performance of cervicography and cytology to detect cervical intraepithelial neoplasia grade 2 or worse. Sensitivity and specificity of cervicography were 84% [95% confidence interval (CI): 72 to 91) and 58% (95% CI: 52 to 64). At the high-grade squamous intraepithelial lesion or worse cutoff for cytology, sensitivity and specificity were 61% (95% CI: 48 to 72) and 58% (95% CI: 52 to 64). In our study, cervicography seems to be as good as cytology in HIV-infected women.
authors: *Centre for Infectious Disease Research in Zambia, Lusaka, Zambia; †University of North Carolina at Chapel Hill, Chapel Hill, NC; ‡University Teaching Hospital, Lusaka, Zambia; §Vanderbilt University, Nashville, TN; ‖University of Cincinnati, Cincinnati, OH; and ¶Michigan Cancer Institute, Pontiac, MI.
authors: Allen C
authors: AC
authors: Bateman
authors: Groesbeck P
authors: GP
authors: Parham
authors: Vikrant V
authors: VV
authors: Sahasrabuddhe
authors: Mulindi H
authors: MH
authors: Mwanahamuntu
authors: Sharon
authors: S
authors: Kapambwe
authors: Katundu
authors: K
authors: Katundu
authors: Theresa
authors: T
authors: Nkole
authors: Jacqueline
authors: J
authors: Mulundika
authors: Krista S
authors: KS
authors: Pfaendler
authors: Michael L
authors: ML
authors: Hicks
authors: Aaron
authors: A
authors: Shibemba
authors: Sten H
authors: SH
authors: Vermund
authors: Jeffrey S A
authors: JS
authors: Stringer
authors: Carla J
authors: CJ
authors: Chibwesha
mesh_terms: D019342:Acetic Acid; D000328:Adult; D003127:Colposcopy / Q000379:methods*; D003584:Cytological Techniques / Q000379:methods*; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D061848:Optical Imaging / Q000379:methods*; D012680:Sensitivity and Specificity; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis*; D055815:Young Adult; D015024:Zambia; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis*
chemical_list: D019342:Acetic Acid