title: Effect of Sipjeondaebo-tang on cancer-induced anorexia and cachexia in CT-26 tumor-bearing mice.
abstract: Cancer-associated anorexia and cachexia are a multifactorial condition described by a loss of body weight and muscle with anorexia, asthenia, and anemia. Moreover, they correlate with a high mortality rate, poor response to chemotherapy, poor performance status, and poor quality of life. Cancer cachexia is regulated by proinflammatory cytokines such as interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and tumor necrosis factor- α (TNF- α). In addition, glucagon like peptide-1 (GIP-1), peptide YY (PYY), ghrelin, and leptin plays a crucial role in food intake. In this study, we investigated the therapeutic effects of one of the traditional herbal medicines, Sipjeondaebo-tang (Juzen-taiho-to in Japanese; SJDBT), on cancer anorexia and cachexia in a fundamental mouse cancer anorexia/cachexia model, CT-26 tumor-bearing mice. SJDBT was more significantly effective in a treatment model where it was treated after anorexia and cachexia than in a prevention model where it was treated before anorexia and cachexia on the basis of parameters such as weights of muscles and whole body and food intakes. Moreover, SJDBT inhibited a production of IL-6, MCP-1, PYY, and GLP-1 and ameliorated cancer-induced anemia. Therefore, our in vivo studies provide evidence on the role of SJDBT in cancer-associated anorexia and cachexia, thereby suggesting that SJDBT may be useful for treating cancer-associated anorexia and cachexia.
authors: Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea.
authors: Youn Kyung
authors: 0000-0001-6576-5547
authors: YK
authors: Choi
authors: Department of Oriental Internal Medicine, College of Oriental Medicine, Gachon University, Seongnam, Republic of Korea.
authors: Ki Yong
authors: KY
authors: Jung
authors: Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea.
authors: Sang-Mi
authors: SM
authors: Woo
authors: Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea.
authors: Yee Jin
authors: 0000-0001-5918-1465
authors: YJ
authors: Yun
authors: Department of Oriental Internal Medicine, College of Oriental Medicine, Gachon University, Seongnam, Republic of Korea.
authors: Chan-Yong
authors: CY
authors: Jun
authors: Department of Oriental Internal Medicine, College of Oriental Medicine, Gachon University, Seongnam, Republic of Korea.
authors: Jong Hyeong
authors: JH
authors: Park
authors: Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea.
authors: Yong Cheol
authors: YC
authors: Shin
authors: Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea.
authors: Sung-Gook
authors: 0000-0002-8791-9532
authors: SG
authors: Cho
authors: Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea.
authors: Seong-Gyu
authors: SG
authors: Ko
mesh_terms: D000818:Animals; D000855:Anorexia / Q000150:complications* / Q000188:drug therapy; D001835:Body Weight; D002100:Cachexia / Q000150:complications* / Q000188:drug therapy; D045744:Cell Line, Tumor; D018932:Chemokine CCL2 / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D054439:Ghrelin / Q000097:blood; D052216:Glucagon-Like Peptide 1 / Q000097:blood; D007249:Inflammation; D015850:Interleukin-6 / Q000097:blood; D007413:Intestinal Mucosa / Q000378:metabolism; D020738:Leptin / Q000097:blood; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009132:Muscles / Q000473:pathology; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000150:complications* / Q000188:drug therapy; D019894:Peptide YY / Q000097:blood; D028321:Plant Preparations / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: C491768:Ccl2 protein, mouse; D018932:Chemokine CCL2; D004365:Drugs, Chinese Herbal; D054439:Ghrelin; D015850:Interleukin-6; D020738:Leptin; D028321:Plant Preparations; D014409:Tumor Necrosis Factor-alpha; C063587:juzentaihoto; D019894:Peptide YY; D052216:Glucagon-Like Peptide 1