title: Antipsychotics and associated risk of out-of-hospital cardiac arrest.
abstract: Antipsychotic drugs have been associated with sudden cardiac death, but differences in the risk of out-of-hospital cardiac arrest (OHCA) associated with different antipsychotic drug classes are not clear. We identified all OHCAs in Denmark (2001-2010). The risk of OHCA associated with antipsychotic drug use was evaluated by conditional logistic regression analysis in case-time-control models. In total, 2,205 (7.6%) of 28,947 OHCA patients received treatment with an antipsychotic drug at the time of the event. Overall, treatment with any antipsychotic drug was associated with OHCA (odds ratio (OR) = 1.53, 95% confidence interval (CI): 1.23-1.89), as was use with typical antipsychotics (OR = 1.66, CI: 1.27-2.17). By contrast, overall, atypical antipsychotic drug use was not (OR = 1.29, CI: 0.90-1.85). Two individual typical antipsychotic drugs, haloperidol (OR = 2.43, CI: 1.20-4.93) and levomepromazine (OR = 2.05, CI: 1.18-3.56), were associated with OHCA, as was one atypical antipsychotic drug, quetiapine (OR = 3.64, CI: 1.59-8.30).
authors: Department of Cardiology, Copenhagen University Hospital, Gentofte, Denmark.
authors: P
authors: P
authors: Weeke
authors: Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark.
authors: A
authors: A
authors: Jensen
authors: Department of Cardiology, Copenhagen University Hospital, Gentofte, Denmark.
authors: F
authors: F
authors: Folke
authors: 1] Department of Cardiology, Copenhagen University Hospital, Gentofte, Denmark [2] National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.
authors: G H
authors: GH
authors: Gislason
authors: Department of Cardiology, Copenhagen University Hospital, Gentofte, Denmark.
authors: J B
authors: JB
authors: Olesen
authors: Department of Cardiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
authors: E L
authors: EL
authors: Fosbøl
authors: Department of Cardiology, Copenhagen University Hospital, Gentofte, Denmark.
authors: M
authors: M
authors: Wissenberg
authors: Prehospital Emergency Medical Services, On behalf of the Capital, Central Denmark, Northern, South Denmark and Zealand Regions, Denmark.
authors: F K
authors: FK
authors: Lippert
authors: Prehospital Emergency Medical Services, On behalf of the Capital, Central Denmark, Northern, South Denmark and Zealand Regions, Denmark.
authors: E F
authors: EF
authors: Christensen
authors: Department of Cardiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
authors: S L
authors: SL
authors: Nielsen
authors: Geriatric Department, Nykøbing Falster Hospital, Nykøbing Falster, Denmark.
authors: E
authors: E
authors: Holm
authors: Laboratory of Experimental Cardiology, University of Copenhagen, Copenhagen, Denmark.
authors: J K
authors: JK
authors: Kanters
authors: Laboratory of Clinical Pharmacology, Copenhagen University Hospital, Bispebjerg, Denmark.
authors: H E
authors: HE
authors: Poulsen
authors: Department of Cardiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
authors: L
authors: L
authors: Køber
authors: Department of Health, Science and Technology, Aalborg University, Aalborg, Denmark.
authors: C
authors: C
authors: Torp-Pedersen
mesh_terms: D000368:Aged; D014150:Antipsychotic Agents / Q000009:adverse effects*; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006323:Heart Arrest / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D014150:Antipsychotic Agents