title: X marks the spot: does it matter that O-GlcNAc transferase is an X-linked gene?
abstract: O-GlcNAcylation has emerged as a critical post-translational modification important for a wide array of cellular processes. This modification has been identified on a large pool of intracellular proteins that have wide-ranging roles, including transcriptional regulation, cell cycle progression, and signaling, among others. Interestingly, in mammals the single gene encoding O-GlcNAc Transferase (OGT) is located on the X-chromosome near the Xist locus suggesting that tight dosage regulation is necessary for normal development. Herein, we highlight the importance of OGT dosage and consider how its genomic location can contribute to a gender-specific increased risk for a number of diseases.
authors: Laboratory of Cellular and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Bethesda, MD 20892, USA.
authors: Stéphanie
authors: S
authors: Olivier-Van Stichelen
authors: Laboratory of Cellular and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Bethesda, MD 20892, USA.
authors: Lara K
authors: LK
authors: Abramowitz
authors: Laboratory of Cellular and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Bethesda, MD 20892, USA. Electronic address: jah@helix.nih.gov.
authors: John A
authors: JA
authors: Hanover
mesh_terms: D000117:Acetylglucosamine / Q000378:metabolism; D000818:Animals; D004303:Dosage Compensation, Genetic; D047108:Embryonic Development / Q000235:genetics / Q000502:physiology; D005260:Female; D050172:Genes, X-Linked; D018392:Genomic Imprinting; D006031:Glycosylation; D006801:Humans; D008297:Male; D051379:Mice; D008954:Models, Biological; D017351:N-Acetylglucosaminyltransferases / Q000235:genetics* / Q000378:metabolism; D011247:Pregnancy; D011499:Protein Processing, Post-Translational; D049951:X Chromosome Inactivation
chemical_list: D017351:N-Acetylglucosaminyltransferases; C449880:O-GlcNAc transferase; D000117:Acetylglucosamine
keywords: Embryogenesis; O-GlcNAc Transferase; O-GlcNAcylation; X-inactivation; X-linked gene