title: Effects of the combined use of a dermal substitute with a cleansing process in the simulation of autologous skin: a pilot study.
abstract: Historically, in severe trauma, such as extensive burns and large loss of substance of the soft tissues, increased emphasis is given to the survival of the traumatized person and less attention is placed on the recovery of the actual traumatized organ. Today, recovery of complete functionality of the injured part and the possibility of minimizing scars in order to make them as acceptable and invisible as possible are also important. The present study analyzed morphologically the events occurring in the wounds of patients in which a dermal substitute was used in combination with a cleansing process. Pre-treatment of the lesion by cleansing followed by the application of a biomaterial showed that in the tissue that forms, a reduced number of cells are present, the collagen is more undulating with interstitial spaces, and Langerhans cells are evident. In addition, these cells participate in the growth and turnover of keratinocytes. The mediating role of these elements would also be strongly dependent on the components of the extracellular matrix of the dermis.
authors: Department of Mental and Physical Health and Preventive Medicine, Section of Human Anatomy, Second University of Naples, Italy angela.lucariello@gmail.com.
authors: Angela
authors: A
authors: Lucariello
authors: Department of Biomorphological and Functional Sciences, University of Naples Federico II, Naples, Italy.
authors: Mariapia
authors: M
authors: Cinelli
authors: Department of Mental and Physical Health and Preventive Medicine, Section of Human Anatomy, Second University of Naples, Italy.
authors: Antonello
authors: A
authors: DE Novellis
authors: Department of Mental and Physical Health and Preventive Medicine, Section of Human Anatomy, Second University of Naples, Italy.
authors: Charalampos
authors: C
authors: Nikolopoulos
authors: Department of Mental and Physical Health and Preventive Medicine, Section of Human Anatomy, Second University of Naples, Italy.
authors: Vicenzo
authors: V
authors: Esposito
authors: Department of Medicine and Health Sciences; University of Molise, Campobasso, Italy.
authors: Germano
authors: G
authors: Guerra
mesh_terms: D000328:Adult; D001706:Biopsy; D003094:Collagen; D020405:Dermis / Q000473:pathology / Q000601:surgery / Q000648:ultrastructure; D004203:Disinfection / Q000379:methods*; D005109:Extracellular Matrix; D005260:Female; D006801:Humans; D007801:Langerhans Cells; D008297:Male; D008875:Middle Aged; D018919:Neovascularization, Physiologic; D010865:Pilot Projects; D016038:Skin Transplantation; D017768:Skin, Artificial; D014945:Wound Healing
chemical_list: D003094:Collagen
keywords: Dermal substitute; Langerhans cells; TEM; keratinocytes