title: Podoplanin--a novel marker in oral carcinogenesis.
abstract: Podoplanin, a transmembrane sialoglycoprotein, is a specific marker for lymphatic endothelial cells which in recent years has gained prominent notoriety for its role in tumor progression and metastasis. It is an extensively studied biomarker for predictive assessment of malignant transformation as well as biologic behavior in both human precancer and cancer, respectively. This review summarizes the association of podoplanin overexpression in oral potentially malignant disorders and oral cancer with special emphasis on its putative role in carcinogenesis as well as its prospective use in targeted therapy.
authors: Department of Oral Pathology, MGM Dental College and Hospital, 304, Siddhi Vinayak Residency Sector 9, Plot no. 40 Kamothe, Navi Mumbai, 410209, Maharashtra, India, niharikadec30@gmail.com.
authors: Niharika
authors: N
authors: Swain
authors: Shwetha V
authors: SV
authors: Kumar
authors: Samapika
authors: S
authors: Routray
authors: Jigna
authors: J
authors: Pathak
authors: Shilpa
authors: S
authors: Patel
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic / Q000378:metabolism* / Q000473:pathology; D018450:Disease Progression; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008954:Models, Biological; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D009362:Neoplasm Metastasis; D011379:Prognosis; D000098853:Podoplanin
chemical_list: D014408:Biomarkers, Tumor; D008562:Membrane Glycoproteins; C117468:PDPN protein, human; D000098853:Podoplanin