title: Ciprofloxacin-collagen conjugate in the wound healing treatment.
abstract: The synthesis of a novel functional biomaterial for wound healing treatment was carried out by adopting a free-radical grafting procedure in aqueous media. With this aim, ciprofloxacin (CFX) was covalently incorporated into collagen (T1C) chains employing an ascorbic acid/hydrogen peroxide redox pair as biocompatible initiator system. The covalent insertion of CFX in the polymeric chains was confirmed by FT-IR and UV analyses, while an antibacterial assay demonstrated the activity of the synthesized conjugate against Staphylococcus aureus and Escherichia coli, microorganisms that commonly infect wounds. A catechin blended conjugate was also tested in order to evaluate the ability to influence fibroblast cell growth. The observed antibacterial activity and stimulation of fibroblast growth support the applicability of CFX-T1C conjugate in wound treatment encouraging the healing process.
authors: Department of Pharmaceutical Sciences, University of Calabria, Edificio Polifunzionale, Arcavacata di Rende (CS) 87036, Italy. francesco.puoci@unical.it.
authors: Francesco
authors: F
authors: Puoci
authors: Principium Europe, Via Como 45, Solaro (MI) 20020, Italy. c.piangiolino@principium-bsi.com.
authors: Cristiana
authors: C
authors: Piangiolino
authors: Department of Thoracic Surgery, Policlinico Universitario Germaneto-Fondazione Tommaso Campanella, Campus Universitario "Salvatore Venuta" Viale Europa, Località Germaneto 88100, Italy. francescogiv@gmail.com.
authors: Francesco
authors: F
authors: Givigliano
authors: Department of Pharmaceutical Sciences, University of Calabria, Edificio Polifunzionale, Arcavacata di Rende (CS) 87036, Italy. ortensiailaria.parisi@unical.it.
authors: Ortensia Ilaria
authors: OI
authors: Parisi
authors: Department of Pharmaceutical Sciences, University of Calabria, Edificio Polifunzionale, Arcavacata di Rende (CS) 87036, Italy. roberta.cassano@unical.it.
authors: Roberta
authors: R
authors: Cassano
authors: Department of Pharmaceutical Sciences, University of Calabria, Edificio Polifunzionale, Arcavacata di Rende (CS) 87036, Italy. sonia.trombino@unical.it.
authors: Sonia
authors: S
authors: Trombino
authors: Department of Pharmaceutical Sciences, University of Calabria, Edificio Polifunzionale, Arcavacata di Rende (CS) 87036, Italy. manuela.curcio@unical.it.
authors: Manuela
authors: M
authors: Curcio
authors: Department of Pharmaceutical Sciences, University of Calabria, Edificio Polifunzionale, Arcavacata di Rende (CS) 87036, Italy. francesca.iemma@unical.it.
authors: Francesca
authors: F
authors: Iemma
authors: Department of Pharmaceutical Sciences, University of Calabria, Edificio Polifunzionale, Arcavacata di Rende (CS) 87036, Italy. giuseppe.cirillo@unical.it.
authors: Giuseppe
authors: G
authors: Cirillo
authors: Department of Pharmaceutical Sciences, University of Calabria, Edificio Polifunzionale, Arcavacata di Rende (CS) 87036, Italy. g.spizzirri@unical.it.
authors: Umile Gianfranco
authors: UG
authors: Spizzirri
authors: Department of Pharmaceutical Sciences, University of Calabria, Edificio Polifunzionale, Arcavacata di Rende (CS) 87036, Italy. donatella.restuccia@unical.it.
authors: Donatella
authors: D
authors: Restuccia
authors: Department of Pharmaceutical Sciences, University of Calabria, Edificio Polifunzionale, Arcavacata di Rende (CS) 87036, Italy. rita.muzzalupo@unical.it.
authors: Rita
authors: R
authors: Muzzalupo
authors: Department of Pharmaceutical Sciences, University of Calabria, Edificio Polifunzionale, Arcavacata di Rende (CS) 87036, Italy. nevio.picci@unical.it.
authors: Nevio
authors: N
authors: Picci