title: Comparative efficacies of cloxacillin-daptomycin and the standard cloxacillin-rifampin therapies against an experimental foreign-body infection by methicillin-susceptible Staphylococcus aureus.
abstract: We compared the efficacies of daptomycin (doses equivalent to 8 to 10 mg/kg of body weight/day in humans) and cloxacillin alone with those of cloxacillin-rifampin and cloxacillin-daptomycin combinations, using a tissue cage methicillin-susceptible Staphylococcus aureus (MSSA) infection model. Monotherapies were less effective than combinations (P<0.05), and daptomycin resistance emerged. Cloxacillin-daptomycin proved as effective as cloxacillin-rifampin and prevented the appearance of resistance; this combination may be an alternative anti-MSSA therapy, which may offer greater benefits in the early treatment of prosthetic joint infections (PJI).
authors: Laboratory of Experimental Infection, Infectious Diseases Service, IDIBELL, Hospital Universitari de Bellvitge, Feixa Llarga, L'Hospitalet Llobregat, Barcelona, Spain celhaj@idibell.cat.
authors: Cristina
authors: C
authors: El Haj
authors: Laboratory of Experimental Infection, Infectious Diseases Service, IDIBELL, Hospital Universitari de Bellvitge, Feixa Llarga, L'Hospitalet Llobregat, Barcelona, Spain.
authors: Oscar
authors: O
authors: Murillo
authors: Laboratory of Experimental Infection, Infectious Diseases Service, IDIBELL, Hospital Universitari de Bellvitge, Feixa Llarga, L'Hospitalet Llobregat, Barcelona, Spain.
authors: Alba
authors: A
authors: Ribera
authors: Laboratory of Experimental Infection, Infectious Diseases Service, IDIBELL, Hospital Universitari de Bellvitge, Feixa Llarga, L'Hospitalet Llobregat, Barcelona, Spain.
authors: Mireia
authors: M
authors: Vivas
authors: Department of Microbiology, IDIBELL, Hospital Universitari de Bellvitge, Feixa Llarga, L'Hospitalet Llobregat, Barcelona, Spain.
authors: Dolors
authors: D
authors: Garcia-Somoza
authors: Department of Microbiology, IDIBELL, Hospital Universitari de Bellvitge, Feixa Llarga, L'Hospitalet Llobregat, Barcelona, Spain.
authors: Fe
authors: F
authors: Tubau
authors: Department of Orthopaedic Surgery, IDIBELL, Hospital Universitari de Bellvitge, Feixa Llarga, L'Hospitalet Llobregat, Barcelona, Spain.
authors: Javier
authors: J
authors: Cabo
authors: Laboratory of Experimental Infection, Infectious Diseases Service, IDIBELL, Hospital Universitari de Bellvitge, Feixa Llarga, L'Hospitalet Llobregat, Barcelona, Spain.
authors: Javier
authors: J
authors: Ariza
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000627:therapeutic use; D003023:Cloxacillin / Q000493:pharmacokinetics / Q000627:therapeutic use*; D017576:Daptomycin / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004338:Drug Combinations; D008826:Microbial Sensitivity Tests; D051381:Rats; D017208:Rats, Wistar; D012293:Rifampin / Q000493:pharmacokinetics / Q000627:therapeutic use*; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D017576:Daptomycin; D003023:Cloxacillin; D012293:Rifampin