title: A concise total synthesis of puberulic acid, a potent antimalarial agent.
abstract: Efficient and practical total synthesis of puberulic acid has been accomplished via 8 steps, with 54% overall yield, and only two C-C bond formations, without the introduction of oxygen atoms into the core skeleton. Construction of the tropolone framework as the key transformation was achieved by multi-tandem oxidation of the aliphatic-triol, from D-(+)-galactose as the starting material.
authors: Graduate School of Infection Control Sciences, Kitasato University, Japan.
authors: Goh
authors: G
authors: Sennari
authors: Tomoyasu
authors: T
authors: Hirose
authors: Masato
authors: M
authors: Iwatsuki
authors: Satoshi
authors: S
authors: Ōmura
authors: Toshiaki
authors: T
authors: Sunazuka
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis*; D002264:Carboxylic Acids / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry; D010407:Penicillium / Q000737:chemistry; D014334:Tropolone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000962:Antimalarials; D002264:Carboxylic Acids; D007202:Indicators and Reagents; C000597460:puberulic acid; D014334:Tropolone; D010100:Oxygen