title: Medical and economic burden of chronic hepatitis B patients at Queen Savang Vadhana Memorial Hospital.
abstract: OBJECTIVE
  To study and to compare the medical and economic burden among chronic hepatitis B (CHB) patients.
  
  
  METHODS
  A prospective observational study was conducted among 129 adult CHB patients. The medical burden was assessed by using the EuroQol-5D (EQ-5D) and the Chronic Liver Disease Questionnaire (CLDQ) at initial day, the six and 12-month follow-up. The economic burden was assessed in term of total cost per case per year
  
  
  RESULTS
  At one-year follow-up, the mean age of 129 patients was 41.6 (SD = 11.8) years. For medical burden at over time, CHB with antiviral drugs (ARV) for hepatitis B infection had a significant decreased in percentage of anxiety, and increased the mean (SD) CLDQ score. The mean total costs per case per year of CHB without ARV (52 cases), CHB with antiviral drugs (50 cases), and CHB with cirrhosis/hepatocellular carcinoma (HCC) with ARV (27 cases) were significantly different (p < 0.001) with USD 615.9 (SD = 688.0), 1,777.4 (SD = 1,220.4), and 2,651.3 (SD = 3,885.0), respectively.
  
  
  CONCLUSIONS
  CHB causes a great economic burden in Thailand Early antiviral drugs treatment prevents complication in CHB patients.
authors: Chuenrutai
authors: C
authors: Yeekian
authors: Nopavut
authors: N
authors: Geratikornsupak
authors: Pongsak
authors: P
authors: Chumpongthong
authors: Sirinat
authors: S
authors: Tongsiri
authors: Jittima
authors: J
authors: Dhitavat
authors: Benjaluck
authors: B
authors: Phonrat
authors: Punnee
authors: P
authors: Pitisuttithum
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000191:economics / Q000627:therapeutic use; D017281:Cost of Illness; D005260:Female; D017048:Health Care Costs; D019694:Hepatitis B, Chronic / Q000191:economics* / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011788:Quality of Life; D013785:Thailand
chemical_list: D000998:Antiviral Agents