title: Self-assembly of DNA-oligo(p-phenylene-ethynylene) hybrid amphiphiles into surface-engineered vesicles with enhanced emission.
abstract: Surface-addressable nanostructures of linearly π-conjugated molecules play a crucial role in the emerging field of nanoelectronics. Herein, by using DNA as the hydrophilic segment, we demonstrate a solid-phase "click" chemistry approach for the synthesis of a series of DNA-chromophore hybrid amphiphiles and report their reversible self-assembly into surface-engineered vesicles with enhanced emission. DNA-directed surface addressability of the vesicles was demonstrated through the integration of gold nanoparticles onto the surface of the vesicles by sequence-specific DNA hybridization. This system could be converted to a supramolecular light-harvesting antenna by integrating suitable FRET acceptors onto the surface of the nanostructures. The general nature of the synthesis, surface addressability, and biocompatibility of the resulting nanostructures offer great promises for nanoelectronics, energy, and biomedical applications.
authors: School of Chemistry, Indian Institute of Science Education and Research-Thiruvananthapuram (IISER-TVM), CET campus, Trivandrum-695016 (India).
authors: Shine K
authors: SK
authors: Albert
authors: Hari Veera Prasad
authors: HV
authors: Thelu
authors: Murali
authors: M
authors: Golla
authors: Nithiyanandan
authors: N
authors: Krishnan
authors: Soma
authors: S
authors: Chaudhary
authors: Reji
authors: R
authors: Varghese
mesh_terms: D004247:DNA / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D009841:Oligonucleotides / Q000737:chemistry*; D013237:Stereoisomerism; D013499:Surface Properties
chemical_list: D009841:Oligonucleotides; D004247:DNA
keywords: DNA nanotechnology; amphiphiles; chromophore; supramolecular chemistry; vesicles