title: Left atrial appendage closure devices.
abstract: Atrial fibrillation (AF) increases the risk for thromboembolic stroke five-fold. The left atrial appendage (LAA) has been shown to be the main source of thrombus formation in the majority of strokes associated with AF. Oral anticoagulation with warfarin and novel anticoagulants remains the standard of care; however, it has several limitations, including bleeding and poor compliance. Occlusion of the LAA has been shown to be an alternative therapeutic approach to drug therapy. The purpose of this article is to review the different techniques and devices that have emerged for the purpose of occluding this structure, with a particular emphasis on the efficacy and safety studies published to date in the medical literature.
authors: Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY, USA.
authors: Jorge
authors: J
authors: Romero
authors: Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY, USA.
authors: Irving E
authors: IE
authors: Perez
authors: Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY, USA.
authors: Andrew
authors: A
authors: Krumerman
authors: Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY, USA.
authors: Mario J
authors: MJ
authors: Garcia
authors: Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY, USA.
authors: Richard J
authors: RJ
authors: Lucariello
keywords: Atrial appendage; Atrial fibrillation; Atrium closure devices; LAA