title: Antithrombotic functions of small molecule-capped gold nanoparticles.
abstract: Here we report the antithrombotic functions of pyrimidinethiol-capped gold nanoparticles (Au_DAPT NPs). They can prolong coagulation parameters when injected intravenously in normal mice. Applied in two typical thrombosis models, mice tail thrombosis and pulmonary thromboembolism, gold NPs can inhibit both thrombosis and improve the survival rates of mice tremendously, without increasing the bleeding risk. The anticoagulant mechanisms include inhibiting the platelet aggregation as well as interfering with thrombin and fibrin generation.
authors: Beijing Engineering Research Center for BioNanotechnology and CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, 11 Beiyitiao, ZhongGuanCun, Beijing, 100190, China. xingyuiijiang@nanoctr.cn zhangw@nanoctr.cn.
authors: Yue
authors: Y
authors: Tian
authors: Yuyun
authors: Y
authors: Zhao
authors: Wenfu
authors: W
authors: Zheng
authors: Wei
authors: W
authors: Zhang
authors: Xingyu
authors: X
authors: Jiang
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000737:chemistry; D001777:Blood Coagulation / Q000187:drug effects; D001792:Blood Platelets / Q000378:metabolism; D005337:Fibrin / Q000737:chemistry; D005343:Fibrinolytic Agents / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D006470:Hemorrhage; D008171:Lung Diseases / Q000503:physiopathology; D008297:Male; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D011743:Pyrimidines / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D013438:Sulfhydryl Compounds / Q000737:chemistry; D013917:Thrombin / Q000737:chemistry; D013927:Thrombosis / Q000503:physiopathology; D014914:Whole Blood Coagulation Time
chemical_list: D000925:Anticoagulants; D005343:Fibrinolytic Agents; D011743:Pyrimidines; D013438:Sulfhydryl Compounds; D006046:Gold; D005337:Fibrin; D013917:Thrombin; C030986:pyrimidine