title: Analysis of Differentially Expressed Genes Associated With Alzheimer's Disease Based on Bioinformatics Methods.
abstract: OBJECTIVE
  To screen differentially expressed genes (DEGs) of Alzheimer's disease (AD).
  
  
  METHODS
  The gene expression profile (GSE26972) of AD was downloaded from Gene Expression Omnibus database. The DEGs were mapped to protein-protein interaction (PPI) data for acquiring the potential PPI relationship. The coexpressed significance of a gene pair in AD was determined. Then significantly enriched Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of DEGs were analyzed based on database for annotation visualization and integrated discovery tool.
  
  
  RESULTS
  The PPI network showed 7 upregulated genes and 4 downregulated genes that might play meaningful functional roles in AD. Meanwhile, 3 significantly enriched KEGG pathways as well as several significant GO terms (included α-actinin binding, interleukin 33 receptor activity, and telethonin binding) were identified.
  
  
  CONCLUSIONS
  The screened DEGs have the potential to become candidate target molecules to monitor, diagnose, and treat AD.
authors: Department of Neurology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong PR China Department of Neurology, Hospital Affiliated to Binzhou medical University, Binzhou, PR China.
authors: Bo
authors: B
authors: Feng
authors: Department of Spine, Hospital Affiliated to Binzhou medical University, Binzhou, PR China.
authors: Peng
authors: P
authors: Hu
authors: Department of Neurology, Hospital Affiliated to Binzhou medical University, Binzhou, PR China.
authors: Jinbo
authors: J
authors: Chen
authors: Department of Neurology, Hospital Affiliated to Binzhou medical University, Binzhou, PR China.
authors: Qingxin
authors: Q
authors: Liu
authors: Department of Neurology, Hospital Affiliated to Binzhou medical University, Binzhou, PR China.
authors: Xizhi
authors: X
authors: Li
authors: Department of Neurology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong PR China duuyiifeng@hotmail.com.
authors: Yifeng
authors: Y
authors: Du
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics*; D019295:Computational Biology / Q000379:methods*; D020869:Gene Expression Profiling; D006801:Humans; D060066:Protein Interaction Maps
keywords: Alzheimer’s disease; differentially expressed genes; functional enrichment analysis; protein–protein interaction network