title: Cyclooxygenase-2 promoter 765C increase of digestive tract cancer risk in the Chinese population: a meta-analysis.
abstract: BACKGROUND
  To evaluate relationship between the cyclooxygenase-2 promoter 765G/C polymorphism and digestive cancer risk in China.
  
  
  METHODS
  A literature search through February 2014 was performed using PubMed, Chinese Biomedical Literature Database (CBM) and China National Knowledge Infrastructure (CNKI) databases, and a meta-analysis was performed with RevMan 5.2 software for odds ratios and 95%CIs.
  
  
  RESULTS
  In total, 9 articles with 3,263 cases and 4,858 controls were included in this meta-analysis.The pooled OR (95%CIs) in the co-dominant model (GC vs GG) was 1.56 [1.19, 2.06], and in the dominant model ((CC+GC) vs GG), the pooled OR was 1.59 [1.21, 2.09] in overall cancers. In the subgroup analysis, stratified by cancer type, significant associations were found that the-765C allele had increased pancreatic cancer and gastric risk. No significant liver cancer and colorectal cancer risk of COX-2 -765G/C polymorphism was found.
  
  
  CONCLUSIONS
  These findings suggest that COX-2-765*C is related to cancer susceptibility and may increase gastric and pancreatic cancer risk.
authors: Department of Emergency, First Affiliated Hospital, Guangxi Medical University, Nanning, China E-mail : tang6985@qq.com.
authors: Yan-Song
authors: YS
authors: Xu
authors: Bo
authors: B
authors: Zhao
authors: Chen-Yan
authors: CY
authors: Long
authors: Hui
authors: H
authors: Li
authors: Xing
authors: X
authors: Lu
authors: Gang
authors: G
authors: Liu
authors: Xiao-Zhun
authors: XZ
authors: Tang
authors: Wei-Zhong
authors: WZ
authors: Tang
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D051546:Cyclooxygenase 2 / Q000235:genetics*; D004067:Digestive System Neoplasms / Q000209:etiology* / Q000235:genetics* / Q000473:pathology; D041981:Gastrointestinal Tract / Q000473:pathology; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012306:Risk; D012307:Risk Factors
chemical_list: D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human