title: [Effect of grain-bean package, grain-bean package dietary fiber and single whole grain dietary fiber on dyslipidemia rats].
abstract: OBJECTIVE
  To observe and compare the effects of grain-bean package, dietary fiber (DF) extracted from grain-bean package, and DF from grain corn on the blood lipids and fatty acid synthase (FAS) activity in high-fat, high-cholesterol feeding induced dyslipidemia rats, and observe its effects on regulation of sterol regulatory element protein-1c (SREBP-1c) mRNA expression in rat liver.
  
  
  METHODS
  Consolidation 50 SD rats of clean grade feeding adaptation for one week, randomly assigned into normal control group, hyperlipidemia model group, grain-bean package group, grain-bean package DF group and grain corn group. Feed with corresponding diets for 8 weeks, and measure the total cholesterol (TC), triglyceridaemia (TG), high density lipoprotein cholesterol (HDL-C), fasting blood glucose (FBG), FAS, SREBP-1c mRNA of all groups.
  
  
  RESULTS
  Compared with control group, TC, TG, FBG levels of hyperlipidemia model group were significantly increased (P < 0.05). Compared with model group, TC, TG, FBG levels of grain-bean package group, grain-bean package DF group were significantly decreased, HDL-C levels significantly increased, and activity of FAS, regulation of SREBP-1c were significantly decreased (P < 0.05).
  
  
  CONCLUSIONS
  The Grain-bean package dietary fiber can improve blood lipids levels of dyslipidemia rats, and decrease FAS activity and SREBP-1c mRNA expression.
authors: Yang
authors: Y
authors: Liu
authors: Chengkai
authors: C
authors: Zhai
authors: Guiju
authors: G
authors: Sun
authors: Hong
authors: H
authors: Zhang
authors: Mingxia
authors: M
authors: Jiang
authors: Haifeng
authors: H
authors: Zhang
authors: Junling
authors: J
authors: Guo
authors: Xi
authors: X
authors: Lan
mesh_terms: D000818:Animals; D002784:Cholesterol; D004043:Dietary Fiber; D002523:Edible Grain; D006949:Hyperlipidemias / Q000517:prevention & control*; D008055:Lipids; D008099:Liver; D012333:RNA, Messenger; D051381:Rats; D051780:Sterol Regulatory Element Binding Protein 1; D014157:Transcription Factors
chemical_list: D004043:Dietary Fiber; D008055:Lipids; D012333:RNA, Messenger; D051780:Sterol Regulatory Element Binding Protein 1; D014157:Transcription Factors; D002784:Cholesterol