title: Identification and comparative analysis of G protein-coupled receptors in Pediculus humanus humanus.
abstract: The body louse has the smallest genome size among the known genome-sequenced insects. Here, 81 GPCRs were identified in Pediculus humanus humanus, 56, 14, 6 and 5 GPCRs for family-A, -B, -C and -D, respectively. These GPCRs constitute the comparable repertoire of GPCRs with other insects. Moreover, it contains a more complete set of neuropeptide and protein hormone receptors not even than Acyrthosiphon pisum but also Drosophila melanogaster, for example, Sulfakinin, Corazonin, Trissin and PTHRL only presented in P. h. humanus but lost either in A. pisum or D. melanogaster. However, it has less duplication among the sub-families. Meanwhile, ACP, AVPL, HE6 receptors and Boss were also absent from P. h. humanus. These results indicated that the repertoire of GPCRs in P. h. humanus were not affected by its smallest genome size, and further suggested that P. h. humanus has a relatively original and concise GPCR regulation system.
authors: Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China. Electronic address: lcj3314@163.com.
authors: Chengjun
authors: C
authors: Li
authors: Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China. Electronic address: xiaowen90@126.com.
authors: Xiaowen
authors: X
authors: Song
authors: Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China. Electronic address: Fengzheng225@126.com.
authors: Xuhong
authors: X
authors: Chen
authors: Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China. Electronic address: mexing@163.com.
authors: Xing
authors: X
authors: Liu
authors: Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China. Electronic address: sangming1105@163.com.
authors: Ming
authors: M
authors: Sang
authors: Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China. Electronic address: ztaiww1314@163.com.
authors: Wei
authors: W
authors: Wu
authors: Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China. Electronic address: yunxiaopei619@126.com.
authors: Xiaopei
authors: X
authors: Yun
authors: Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China. Electronic address: whhuxingxing@163.com.
authors: Xingxing
authors: X
authors: Hu
authors: Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China. Electronic address: libin@njnu.edu.cn.
authors: Bin
authors: B
authors: Li
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000235:genetics; D004330:Drosophila / Q000145:classification / Q000235:genetics; D029721:Drosophila Proteins / Q000235:genetics; D019143:Evolution, Molecular; D005136:Eye Proteins / Q000235:genetics; D049750:Genome, Insect; D019476:Insect Proteins / Q000235:genetics; D008562:Membrane Glycoproteins / Q000235:genetics; D009479:Neuropeptides / Q000235:genetics; D010374:Pediculus / Q000145:classification / Q000235:genetics*; D010802:Phylogeny; D043562:Receptors, G-Protein-Coupled / Q000235:genetics*; D018000:Receptors, Peptide / Q000235:genetics; D016415:Sequence Alignment
chemical_list: D002352:Carrier Proteins; D029721:Drosophila Proteins; D005136:Eye Proteins; D019476:Insect Proteins; D008562:Membrane Glycoproteins; D009479:Neuropeptides; D043562:Receptors, G-Protein-Coupled; D018000:Receptors, Peptide; C568475:Trissin protein, Drosophila; C072141:boss protein, Drosophila; C060602:corazonin protein, insect
keywords: Biogenic amine; Corazonin; GPCR; Neuropeptide; Pediculus humanus humanus; Sulfakinin