title: Cytological characteristics of papillary thyroid carcinoma on LBC specimens, compared with conventional specimens.
abstract: BACKGROUND
  The cytological findings in conventional specimens (C-S) and liquid-based cytology specimens (LBC-S) are not quite same. The aim of this article is to clarify the cytological findings of papillary thyroid carcinoma (PTC) characteristic of LBC-S.
  
  
  METHODS
  Out of 5,971 cases diagnosed in a single institution from March to September in 2012, 161 PTC cases with both C-S and LBC-S were reviewed. Additionally, we compared the findings with those in LBC-S of 55 adenomatous or hyperplastic nodule (AN) and 21 follicular neoplasm (FN) cases.
  
  
  RESULTS
  Compared to C-S, the incidences of trabecular and hobnail patterns, collagenous stroma, naked capillaries, intercellular spaces, convoluted nuclei, eosinophilic nucleoli, and perinucleolar halo were increased. Pale nuclei were observed in only one of 161 PTC cases. Specificity of convoluted nuclei and perinucleolar halo were 97.4% and 96.1%, respectively.
  
  
  CONCLUSIONS
  Convoluted nuclei and perinucleolar halo might become a new indicator of PTC in LBC-S. Contrarily, we should be aware that pale nuclei are rarely observed in LBC-S.
authors: Department of Laboratory, Kuma Hospital, Kobe, Hyogo, Japan.
authors: Ayana
authors: A
authors: Suzuki
authors: Mitsuyoshi
authors: M
authors: Hirokawa
authors: Miyoko
authors: M
authors: Higuchi
authors: Naoki
authors: N
authors: Yamao
authors: Seiji
authors: S
authors: Kuma
authors: Hirotoshi
authors: H
authors: Nakamura
authors: Nobuyuki
authors: N
authors: Amino
authors: Akira
authors: A
authors: Miyauchi
mesh_terms: D044963:Biopsy, Fine-Needle / Q000379:methods; D002277:Carcinoma / Q000473:pathology*; D002291:Carcinoma, Papillary; D006801:Humans; D065006:Papanicolaou Test / Q000379:methods; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000473:pathology*
keywords: convoluted nuclei; cytology; liquid-based cytology; papillary carcinoma; thyroid