title: Umbilical cord blood acid-base status in pregnancy with congenital heart disease.
abstract: BACKGROUND
  The risk of fetal and neonatal complications is higher in pregnant women with congenital heart disease (CHD). It remains unknown whether umbilical cord blood gas values are different between pregnant women with CHD and healthy women undergoing elective cesarean section during combined spinal-epidural anesthesia. The purpose of the present study was to compare umbilical cord blood acid-base status and gas values in pregnant women with CHD vs. healthy pregnant women undergoing elective cesarean section during combined spinal-epidural (CSE) anesthesia.
  
  
  METHODS
  Patients with singleton pregnancy undergoing elective cesarean delivery under CSE anesthesia were enrolled. Patients were divided into two groups: healthy pregnant women (group H) and pregnant with congenital heart disease (group CHD). Immediately after delivery, umbilical cord arterial blood sample and venous blood sample were collected and measured. The comparison between two groups was performed using grouped t-test.
  
  
  RESULTS
  Forty-four women in group H and 33 women in group CHD were analyzed finally. Umbilical arterial blood pH, base excess (BE) and HCO3 (-) (pH 7.29 ± 0.05, BE -1.4 ± 1.9 mmol/L, HCO3 (-) 21.5 ± 1.4 mmol/L) were significantly lower in pregnant women with CHD than in healthy pregnant women (pH 7.33 ± 0.03, BE -0.1 ± 2.1 mmol/L, HCO3 (-) 22.5 ± 1.4 mmol/L).
  
  
  CONCLUSIONS
  The lower values of umbilical arterial blood pH, BE and HCO3 (-) were observed in pregnant women with CHD than in healthy women undergoing elective cesarean section during CSE anesthesia.
authors: Department of Anesthesia, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors: Q
authors: Q
authors: Zhan
authors: X
authors: X
authors: Wang
authors: J
authors: J
authors: Yu
authors: Y
authors: Y
authors: Fan
mesh_terms: D000137:Acid-Base Imbalance / Q000453:epidemiology / Q000209:etiology*; D000328:Adult; D000767:Anesthesia, Epidural / Q000009:adverse effects; D000773:Anesthesia, Obstetrical / Q000009:adverse effects; D000775:Anesthesia, Spinal / Q000009:adverse effects; D001034:Apgar Score; D001639:Bicarbonates / Q000097:blood; D001724:Birth Weight; D002585:Cesarean Section; D017558:Elective Surgical Procedures; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005865:Gestational Age; D006330:Heart Defects, Congenital / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006976:Hypertension, Pulmonary / Q000209:etiology / Q000503:physiopathology; D007022:Hypotension / Q000188:drug therapy / Q000209:etiology; D007231:Infant, Newborn; D007744:Obstetric Labor Complications / Q000188:drug therapy / Q000209:etiology; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000503:physiopathology*; D015995:Prevalence
chemical_list: D001639:Bicarbonates