title: Serum lipids, apolipoproteins, and mortality among coronary artery disease patients.
abstract: The proatherogenic effect of low-density lipoprotein cholesterol (LDL-C) and antiatherogenic effect of high-density lipoprotein cholesterol (HDL-C) have been confirmed in general population. But controversy arises among coronary artery disease (CAD) patients. The goal of this study was to identify the association of different lipid measurements with CAD prognosis. The study cohort included 1916 CAD patients who were 40-85 years of age. Cox proportional hazards regression models were used to estimate the association of baseline 6 lipid factors and 3 ratios with all-cause and cardiovascular (CVD) mortality. During a median follow-up of 3.1 years, 147 deaths were recorded, 113 of which were due to CVD. When lipid factors were categorized, HDL-C showed a U-shape association with all-cause and CVD mortality after adjustment for major CVD risk factors. Serum LDL-C, apoB, LDL/HDL ratio, and apoB/apoA-I ratio were positively, and apoA-I level was inversely associated with the risk of CVD mortality. After further pairwise comparison of lipid-related risk, LDL/HDL ratio and LDL-C had stronger association with all-cause and CVD mortality than other proatherogenic measurements among Chinese CAD patients.
authors: Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, No. 74 Zhongshan Road 2, Guangzhou, Guangdong 510080, China ; Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA.
authors: Ding
authors: 0000-0002-4559-5904
authors: D
authors: Ding
authors: Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, No. 74 Zhongshan Road 2, Guangzhou, Guangdong 510080, China.
authors: Xinrui
authors: 0000-0001-7158-4785
authors: X
authors: Li
authors: Department of Cardiology, General Hospital of Guangzhou Military Command of People's Liberation Army, Guangdong 510010, China.
authors: Jian
authors: J
authors: Qiu
authors: Department of Cardiology, General Hospital of Guangzhou Military Command of People's Liberation Army, Guangdong 510010, China.
authors: Rui
authors: R
authors: Li
authors: Department of Cardiology, General Hospital of Guangzhou Military Command of People's Liberation Army, Guangdong 510010, China.
authors: Yuan
authors: Y
authors: Zhang
authors: Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, No. 74 Zhongshan Road 2, Guangzhou, Guangdong 510080, China.
authors: Dongfang
authors: 0000-0002-9384-1479
authors: D
authors: Su
authors: Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, No. 74 Zhongshan Road 2, Guangzhou, Guangdong 510080, China.
authors: Zhongxia
authors: Z
authors: Li
authors: Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, No. 74 Zhongshan Road 2, Guangzhou, Guangdong 510080, China.
authors: Min
authors: M
authors: Wang
authors: Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, No. 74 Zhongshan Road 2, Guangzhou, Guangdong 510080, China.
authors: Xiaofei
authors: X
authors: Lv
authors: Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, No. 74 Zhongshan Road 2, Guangzhou, Guangdong 510080, China.
authors: Dongliang
authors: D
authors: Wang
authors: Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, No. 74 Zhongshan Road 2, Guangzhou, Guangdong 510080, China.
authors: Yan
authors: Y
authors: Yang
authors: Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, No. 74 Zhongshan Road 2, Guangzhou, Guangdong 510080, China.
authors: Min
authors: M
authors: Xia
authors: Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, No. 74 Zhongshan Road 2, Guangzhou, Guangdong 510080, China.
authors: Dan
authors: D
authors: Li
authors: Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA.
authors: Gang
authors: 0000-0002-6172-8017
authors: G
authors: Hu
authors: Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, No. 74 Zhongshan Road 2, Guangzhou, Guangdong 510080, China.
authors: Wenhua
authors: 0000-0002-5468-6605
authors: W
authors: Ling
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016632:Apolipoprotein A-I / Q000097:blood; D001053:Apolipoproteins / Q000097:blood*; D001055:Apolipoproteins B / Q000097:blood; D002681:China / Q000453:epidemiology; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood* / Q000401:mortality*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D016896:Treatment Outcome
chemical_list: D016632:Apolipoprotein A-I; D001053:Apolipoproteins; D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL