title: Asthma control in elderly asthmatics. An Italian observational study.
abstract: BACKGROUND
  The exponential increase of individuals aged >64 yrs is expected to impact the burden of asthma. We aimed to explore the level of asthma control in elderly subjects, and factors influencing it.
  
  
  METHODS
  A multicenter observational study was performed on consecutive patients >64 years old with a documented physician-diagnosis of asthma. Sixteen Italian centers were involved in this 6-month project.
  
  
  RESULTS
  A total of 350 patients were enrolled in the study. More than one-third of elderly asthmatic patients, despite receiving GINA step 3-4 antiasthmatic therapy, had an Asthma Control Test score ≤19, with a quarter experiencing at least one severe asthma exacerbation in the previous year. Twenty-nine percent of patients (n = 101) were classified as having Asthma-COPD Overlap Syndrome (ACOS) due to the presence of chronic bronchitis and/or CO lung diffusion impairment. This subgroup of patients had lower mean Asthma Control Test scores and more exacerbations compared to the asthmatic patients (18 ± 4 compared to 20 ± 4, p < 0.01, and 43% compared to 18%, p < 0.01, respectively). Modified Medical Research Council dyspnea mMRC scores and airway obstruction, assessed on the basis of a FEV(1)/FVC ratio below the lower limit of normal, were more severe in ACOS than in asthma, without any difference in responses to salbutamol. In a multivariate analysis, the mMRC dyspnea score, FEV(1)% of predicted and the coexistence of COPD were the only variables to enter the model.
  
  
  CONCLUSIONS
  Our results highlight the need to specifically evaluate the coexistence of features of COPD in elderly asthmatics, a factor that worsens asthma control.
authors: Struttura Complessa di Pneumologia, Azienda Sanitaria Locale 2 Savonese, Pietra Ligure, Italy. Electronic address: manlio.milanese@unige.it.
authors: M
authors: M
authors: Milanese
authors: Struttura Complessa di Pneumologia Ospedale S. Paolo, Dipartimento di Scienze della Salute, Università degli Studi di Milano, Italy.
authors: F
authors: F
authors: Di Marco
authors: Struttura Complessa di Pneumologia, Fondazione IRCCS Policlinico San Matteo, Dipartimento di Medicina Molecolare, Università di Pavia, Pavia, Italy.
authors: A G
authors: AG
authors: Corsico
authors: Allergologia e Immunologia Clinica Università di Torino, Azienda Ospedaliera Ordine Mauriziano, Torino, Italy.
authors: G
authors: G
authors: Rolla
authors: Pneumologia, Azienda Ospedale Misericordia, Grosseto, Italy.
authors: B
authors: B
authors: Sposato
authors: Struttura Complessa di Fisiopatologia Respiratoria, Azienda Ospedaliera di Padova, Padova, Italy.
authors: F
authors: F
authors: Chieco-Bianchi
authors: Struttura Complessa di Pneumologia, Azienda Ospedaliera Carlo Poma di Mantova, Mantova, Italy.
authors: M T
authors: MT
authors: Costantino
authors: Servizio di Allergologia, Medicina del Lavoro, Azienda Ospedaliera Università degli Studi di Padova, Padova, Italy.
authors: M A
authors: MA
authors: Crivellaro
authors: Fisiopatologia Respiratoria, Medicina del Lavoro, Università di Padova, Padova, Italy.
authors: G
authors: G
authors: Guarnieri
authors: DIBIMIS, Università degli Studi di Palermo, Palermo, Italy.
authors: N
authors: N
authors: Scichilone
mesh_terms: D000368:Aged; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use; D001249:Asthma / Q000150:complications / Q000503:physiopathology / Q000517:prevention & control*; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D008297:Male; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications; D016896:Treatment Outcome; D014797:Vital Capacity / Q000502:physiology
chemical_list: D018927:Anti-Asthmatic Agents
keywords: Asthma; Asthma control test; Elderly