title: Value of MR diffusion imaging in hepatic fibrosis and its correlations with serum indices.
abstract: OBJECTIVE
  To compare apparent diffusion coefficient (ADC) values on diffusion-weighted imaging (DWI) of hepatic fibrosis patients with those of healthy controls and to identify their correlations with serum indices of liver fibrosis.
  
  
  METHODS
  Hyaluronic acid (HA), laminin (LN), type III procollagen (PCIII), and collagen type IV (IV-C) were measured in 54 hepatic fibrosis patients and 23 normal controls, and ADC values were determined on DWI at different b values (b = 300, 500, 700 s/mm(2)). Correlations between serum indices and ADC values at different liver fibrosis stages were examined, and each index variation of liver fibrosis in different stages were compared, and correlation analysis of each index and the staging of liver fibrosis carried out, and the correlation of each index performed.
  
  
  RESULTS
  With progressive liver fibrosis, HA, PCIII, and IV-C levels increased (P < 0.01). As the b value increased, the ADC value decreased gradually with the hepatic fibrosis stages. In different groups with b values of 500 s/mm(2) and 700 s/mm(2), the ADC value decreased significantly as liver fibrosis progressed (P < 0.01). With b values of 500 s/mm(2) and 700 s/mm(2), there were negative correlations between ADC and LN, PCIII, HA, and IV-C. This pattern was observed only for HA and IV-C at a b value of 300 s/mm(2).
  
  
  CONCLUSIONS
  Serum indices of liver fibrosis and ADC values are useful for diagnosing liver fibrosis, with some correlations among them.
authors: Xing-Rong Hu, Department of Imaging, The Central Hospital of Enshi Autonomous Prefecture, The Enshi Clinical College of Wuhan University, Enshi 445000, Hubei Province, China.
authors: Xing-Rong
authors: XR
authors: Hu
authors: Xing-Rong Hu, Department of Imaging, The Central Hospital of Enshi Autonomous Prefecture, The Enshi Clinical College of Wuhan University, Enshi 445000, Hubei Province, China.
authors: Xian-Nian
authors: XN
authors: Cui
authors: Xing-Rong Hu, Department of Imaging, The Central Hospital of Enshi Autonomous Prefecture, The Enshi Clinical College of Wuhan University, Enshi 445000, Hubei Province, China.
authors: Qi-Tuo
authors: QT
authors: Hu
authors: Xing-Rong Hu, Department of Imaging, The Central Hospital of Enshi Autonomous Prefecture, The Enshi Clinical College of Wuhan University, Enshi 445000, Hubei Province, China.
authors: Jun
authors: J
authors: Chen
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D016022:Case-Control Studies; D024061:Collagen Type III / Q000097:blood; D024141:Collagen Type IV / Q000097:blood; D038524:Diffusion Magnetic Resonance Imaging; D018450:Disease Progression; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood; D007797:Laminin / Q000097:blood; D008099:Liver / Q000378:metabolism / Q000473:pathology*; D008103:Liver Cirrhosis / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011347:Procollagen / Q000097:blood; D011379:Prognosis; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D015415:Biomarkers; D024061:Collagen Type III; D024141:Collagen Type IV; D007797:Laminin; D011347:Procollagen; D006820:Hyaluronic Acid
keywords: Biological marker; Diffusion-weighted imaging; Hyaluronic acid; Laminin; Liver cirrhosis