title: Impact of conditioning hyperglycemic on myocardial infarction rats: Cardiac cell survival factors.
abstract: While clinical data have suggested that the diabetic heart is more susceptible to ischemic heart disease (IHD), animal data have so far pointed to a lower probability of IHD. Thus, the aim of this present review is to look at these conflicting results and discuss the protective mechanisms that conditioned hyperglycemia may confer to the heart against ischemic injury. Several mechanisms have been proposed to explain the cardioprotective action of high glucose exposure, namely, up-regulation of anti-apoptotic factor Bcl-2, inactivation of pro-apoptotic factor bad, and activation of pro-survival factors such as protein kinase B (Akt), vascular endothelial growth factor (VEGF), hypoxia inducible factor-1α and protein kinase C-ε. Indeed, cytosolic increase in Ca(2+) concentration, the mitochondrial permeability transition pore, plays a key role in the genesis of ischemic injury. Previous studies have shown that the diabetic heart decreased Na(+)/Ca(2+) and Na(+)/H(+) exchanger activity and as such it accumulates less Ca(2+) in cardiomyocyte, thus preventing cardiac injury and the associated heart dysfunctions. In addition, the expression of VEGF in diabetic animals leads to increased capillary density before myocardial infarction. Despite poor prognostic in the long-term, all these results suggest that diabetes mellitus and consequently hyperglycemia may indeed play a cardioprotective role against myocardial infarction in the short term.
authors: Christiane Malfitano, Laboratório de Fisiologia Translacional, UNINOVE, 01504001 São Paulo, Brazil.
authors: Christiane
authors: C
authors: Malfitano
authors: Christiane Malfitano, Laboratório de Fisiologia Translacional, UNINOVE, 01504001 São Paulo, Brazil.
authors: Alcione Lescano
authors: AL
authors: de Souza Junior
authors: Christiane Malfitano, Laboratório de Fisiologia Translacional, UNINOVE, 01504001 São Paulo, Brazil.
authors: Maria Cláudia
authors: MC
authors: Irigoyen
keywords: Cardioprotection; Conditioned hyperglycemia; Diabetes mellitus; Myocardial infarction; Survival factors