title: Cerebrospinal fluid apolipoprotein E and phospholipid transfer protein activity are reduced in multiple sclerosis; relationships with the brain MRI and CSF lipid variables.
abstract: Apolipoprotein E (apoE), phospholipid transfer protein (PLTP) activity, lipids, total tau and beta amyloid 1-42 (Aβ42) were measured in cerebrospinal fluid (CSF) from controls (n=38) and multiple sclerosis (MS) patients (n=91). ApoE and PLTP activity were significantly reduced in MS compared to non-inflammatory disease controls (NINDC; p<0.05). In NINDC and MS, apoE correlated with PLTP activity (rs=0.399 and 0.591, respectively), Aβ42(rs= 0.609 and 0.483, respectively), and total tau (rs=0.748 and 0.380, respectively; all p<0.05). CSF apoE and PLTP significantly contributed to the variance of the normalized brain volume (NBV) and T2 lesion volume in MS (p<0.001 and p<0.05, respectively). ApoE correlated with CSF cholesterol and 24-hydroxycholesterol in all groups; PLTP activity correlated with CSF cholesterol in controls (p<0.05).
authors: Northwest Lipid Metabolism and Diabetes Research Laboratories, 401 Queen Anne Ave N, University of Washington, Department of Medicine, Seattle, WA 98109, USA.
authors: Simona
authors: S
authors: Vuletic
authors: Northwest Lipid Metabolism and Diabetes Research Laboratories, 401 Queen Anne Ave N, University of Washington, Department of Medicine, Seattle, WA 98109, USA.
authors: Hal
authors: H
authors: Kennedy
authors: Northwest Lipid Metabolism and Diabetes Research Laboratories, 401 Queen Anne Ave N, University of Washington, Department of Medicine, Seattle, WA 98109, USA.
authors: John J
authors: JJ
authors: Albers
authors: Department of Neurology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
authors: Joep
authors: J
authors: Killestein
authors: Department of Radiology, Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands ; Department of Physics and Medical Technology, PK-1 X 104, VU University Medical Center, De Boelelaan 1118, 1081 HZ Amsterdam, The Netherlands.
authors: Hugo
authors: H
authors: Vrenken
authors: Institute for Clinical Chemistry and Clinical Pharmacology, University Clinics of Bonn, Sigmund-Freud-Str. 25, D-53127 Bonn, Germany.
authors: Dieter
authors: D
authors: Lütjohann
authors: Neurological Laboratory, Department of Clinical Chemistry, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
authors: Charlotte E
authors: CE
authors: Teunissen
keywords: apolipoprotein E; atrophy; biomarkers; cerebrospinal fluid; multiple sclerosis; phospholipid transfer protein