title: Dynamic transcriptional events in distal sural nerve revealed by transcriptome analysis.
abstract: Compared with biochemical information available about the diseases in the central nervous system, that for peripheral neuropathy is quite limited primarily due to the difficulties in obtaining samples. Characterization of the core pathology is a prerequisite to the development of personalized medicine for genetically heterogeneous diseases, such as hereditary motor and sensory neuropathy (HMSN). Here, we first documented the transcriptome profile of distal sural nerve obtained from HMSN patients. RNA-seq analysis revealed that over 12,000 genes are expressed in distal sural nerve. Among them 4,000 transcripts are novel and 10 fusion genes per sample were observed. Comparing dataset from whole exome sequencing revealed that over 1,500 transcriptional base modifications occur during transcription. These data implicate that dynamic alterations are generated when genetic information are transitioned in distal sural nerve. Although, we could not find significant alterations associated with HMSN, these data might provide crucial information about the pathophysiology of HMSN. Therefore, next step in the development of therapeutic strategy for HMSN might be unveiling biochemical and biophysical abnormalities derived from those potent variation.
authors: Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea.
authors: Young Bin
authors: YB
authors: Hong
authors: Department of Biochemistry, Ewha Womans University School of Medicine, Seoul 158-710, Korea.
authors: Sung-Chul
authors: SC
authors: Jung
authors: Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea.
authors: Jinho
authors: J
authors: Lee
authors: Department of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 110-746, Korea.
authors: Heui-Soo
authors: HS
authors: Moon
authors: Department of Biological Science, Kongju National University, Gongju 314-701, Korea.
authors: Ki Wha
authors: KW
authors: Chung
authors: Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea.
authors: Byung-Ok
authors: BO
authors: Choi
keywords: distal sural nerve; hereditary motor and sensory neuropathy (HMSN); peripheral nervous system (PNS); transcriptome