title: Trifluoromethylation of alkenes with concomitant introduction of additional functional groups.
abstract: The trifluoromethyl group is found in many synthetic bioactive compounds, and the difunctionalization of a C=C bond, as a powerful strategy for the construction of compounds with various functional groups, has been intensively investigated. Therefore, the difunctionalizing trifluoromethylation of alkenes has attracted growing interest because of the potential of the products as building blocks for bioactive molecules. In this review, we focus on recent advances in the trifluoromethylation of alkenes with concomitant introduction of additional functional groups.
authors: Synthetic Organic Chemistry Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan); Sodeoka Live Cell Chemistry Project, ERATO, JST, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan).
authors: Hiromichi
authors: H
authors: Egami
authors: Mikiko
authors: M
authors: Sodeoka
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D008745:Methylation; D015394:Molecular Structure
chemical_list: D000475:Alkenes
keywords: alkenes; difunctionalization; electrophilic trifluoromethylation; homogeneous catalysis