title: Association of insulin-related serum factors with colorectal polyp number and type in adult males.
abstract: BACKGROUND
  Dysregulated insulin signaling is thought to contribute to cancer risk.
  
  
  METHODS
  To determine if insulin-related serum factors are associated with colon polyps, 126 asymptomatic men (48-65 years) were recruited at colonoscopy. Blood was collected. Odds ratios were determined using polytomous logistic regression for polyp number and type.
  
  
  RESULTS
  Males with serum C-peptide concentration >3.3 ng/mL were 3.8 times more likely to have an adenoma relative to no polyp than those with C-peptide ≤1.8 ng/mL. As C-peptide tertile increased, an individual was 2 times more likely to have an adenoma (P = 0.01) than no polyp. There were no associations between insulin-like growth factor or its binding proteins with polyp number or type. Males with soluble receptor for advanced glycation end products (sRAGE) concentration >120.4 pg/mL were 0.25 times less likely to have ≥3 polyps relative to no polyps compared with males with sRAGE ≤94.5 pg/mL. For each increase in sRAGE tertile, a man was 0.5 times less likely to have ≥3 polyps than no polyps (P = 0.03). Compared with males with a serum vascular endothelial growth factor (VEGF) concentration ≤104.7 pg/mL, males with a serum VEGF concentration >184.2 pg/mL were 3.4 times more likely to have ≥3 polyps relative to no polyps. As the VEGF tertile increased, a man was 1.9 times more likely to have ≥3 polyps than no polyps (P = 0.049).
  
  
  CONCLUSIONS
  Serum concentrations of C-peptide, sRAGE, and VEGF may indicate which men could benefit most from colonoscopy.
  
  
  CONCLUSIONS
  Identification of biomarkers could reduce medical costs through the elimination of colonoscopies on low-risk individuals.
authors: Department of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan.
authors: Sarah S
authors: SS
authors: Comstock
authors: Department of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan.
authors: Diana
authors: D
authors: Xu
authors: College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan.
authors: Kari
authors: K
authors: Hortos
authors: College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan. Tri-County Gastroenterology, P.C., Charter Township of Clinton, Michigan.
authors: Bruce
authors: B
authors: Kovan
authors: College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan.
authors: Sarah
authors: S
authors: McCaskey
authors: Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, Michigan.
authors: Dorothy R
authors: DR
authors: Pathak
authors: Department of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan. College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan. imigjeni@msu.edu.
authors: Jenifer I
authors: JI
authors: Fenton
mesh_terms: D000236:Adenoma / Q000097:blood / Q000473:pathology; D000368:Aged; D002096:C-Peptide / Q000097:blood*; D003111:Colonic Polyps / Q000097:blood* / Q000473:pathology*; D003113:Colonoscopy / Q000379:methods; D015179:Colorectal Neoplasms / Q000097:blood / Q000473:pathology; D017127:Glycation End Products, Advanced / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D013002:Somatomedins / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
chemical_list: D002096:C-Peptide; D017127:Glycation End Products, Advanced; D007328:Insulin; D013002:Somatomedins; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; C050920:insulin-related factor