title: Association between aggregative adherence fimbriae types including putative new variants and virulence-related genes and clump formation among aggR-positive Escherichia coli strains isolated in Thailand and Japan.
abstract: Enteroaggregative Escherichia coli (EAggEC) are an important cause of diarrhea. Four types of AAF have been identified; however, their prevalence and association with virulence properties remain unclear. E. coli strains carrying the aggR gene as EAggEC that were isolated in Japan and Thailand (n = 90) were examined for AAF subunit genes, two toxin genes (pet/astA), and clump formation. The most prevalent AAF gene was hdaA (28%), followed by aafA (20%), aggA (12%), and agg3A (4%), as well as a putative new AAF sequence (25.6%). Retention status of the toxin genes and intensities of clump formation appeared to vary according to the AAF type.
authors: Department of Bacteriology I, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo, 162-8640.
authors: Kenitiro
authors: K
authors: Ito
authors: Shigeru
authors: S
authors: Matsushita
authors: Mitsugu
authors: M
authors: Yamazaki
authors: Kazuo
authors: K
authors: Moriya
authors: Takayuki
authors: T
authors: Kurazono
authors: Noriaki
authors: N
authors: Hiruta
authors: Hiroshi
authors: H
authors: Narimatsu
authors: Nobuhiro
authors: N
authors: Ueno
authors: Junko
authors: J
authors: Isobe
authors: Jun
authors: J
authors: Yatsuyanagi
authors: Norimichi
authors: N
authors: Kumagai
authors: Michiko
authors: M
authors: Hashimoto
authors: Orn-Anong
authors: OA
authors: Ratchtrachenchai
mesh_terms: D001422:Bacterial Adhesion; D004926:Escherichia coli / Q000145:classification / Q000235:genetics / Q000302:isolation & purification* / Q000502:physiology; D004927:Escherichia coli Infections / Q000382:microbiology*; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism*; D010861:Fimbriae, Bacterial / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007564:Japan; D013785:Thailand; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism*; D037521:Virulence Factors / Q000235:genetics / Q000378:metabolism
chemical_list: C088603:AggR protein, E coli; D029968:Escherichia coli Proteins; D015534:Trans-Activators; D037521:Virulence Factors
keywords: aggR-positive Escherichia coli; aggregative adherence (AA); aggregative adherence fimbriae (AAF) type; toxin gene