title: Ce³⁺ sensitized GdPO₄:Tb³⁺ with iron oxide nanoparticles: a potential biphasic system for cancer theranostics.
abstract: We report a biphasic system (BPS) consisting of PEGylated Tb(3+)-doped GdPO4 nanorice sensitized with Ce(3+) (PEG-NRs) and glutamic acid coated iron oxide nanoparticles (IONPs) with multifunctional capabilities. The mesoporous PEG-NRs exhibit green light luminescence properties and a high degree of aqueous stability. Their drug loading and release capacities were investigated for anti-cancer chemo doxorubicin (DOX). Their mesoporous nature and availability of plenty of negatively charged functional groups (-COO(-)) on the surface of PEG-NRs facilitate approximately 94 wt% DOX loading. In vitro studies carried out for PEG-NRs and their biphasic integrated system with iron oxide using HeLa and MCF-7 cell lines demonstrated their cell killing efficacy. The green luminescence observed under confocal laser scanning microscopy (CLSM) confirms the cellular uptake of PEG-NRs by HeLa cell lines and their accumulation in the cytoplasm. Approximately 50-55% of HeLa and MCF-7 cell death was observed after 24 h of incubation with DOX loaded BPS (2 mg IONPs and 0.25 mg PEG-NRs + DOX), which further increased to about 90% when exposed to an AC magnetic field (ACMF) for 25 min. Our findings demonstrate that the therapeutic efficacy of BPS loaded with DOX could be a powerful multimodal system for imaging and synergistic chemo-thermal cancer therapy.
authors: Department of Metallurgical Engineering and Materials Science, Indian Institute of Technology Bombay, Mumbai 400 076, India. dhirenb@iitb.ac.in.
authors: Niroj Kumar
authors: NK
authors: Sahu
authors: Naorem Shanta
authors: NS
authors: Singh
authors: Lina
authors: L
authors: Pradhan
authors: Dhirendra
authors: D
authors: Bahadur
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002563:Cerium / Q000737:chemistry*; D004337:Drug Carriers; D005290:Ferric Compounds / Q000737:chemistry*; D005682:Gadolinium / Q000737:chemistry*; D006801:Humans; D049449:Luminescence; D053768:Metal Nanoparticles / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology; D010710:Phosphates / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D005290:Ferric Compounds; D009942:Organometallic Compounds; D010710:Phosphates; C000499:ferric oxide; D002563:Cerium; D005682:Gadolinium