title: Serum levels of thrombotic markers in patients with acute myocardial infarction.
abstract: Tissue plasminogen activator (TPA) and plasminogen activator inhibitor-1 (PAI-1) have pro- and anti-fibrinolytic activities respectively. The net fibrinolytic activity is mainly determined by the balance between TPA and PAI-1 levels. Considering the important role of these markers in thrombotic pathway, we determined the levels of TPA and PAI-1 in sera of 50 AMI patients, 100 patients with associated risk factors (dyslipidemia and high blood pressure) and 100 healthy controls. The findings showed significantly high levels of TPA and PAI-1 in AMI patients as compared to control subjects. Both these markers were only non-significantly increased in the risk group. There was no correlation between body mass index and these markers however TPA and PAI-1 were significantly correlated with age and systolic blood pressure, respectively. In conclusion, a combination of these markers could provide a useful tool to assess the prognosis of AMI.
authors: Department of Biochemistry, College of Science, King Saud University Riyadh 11451, Saudi Arabia.
authors: Shafiqul
authors: S
authors: Islam
authors: Biomarkers Research Lab, Department of Biochemistry, College of Science, King Saud University Riyadh 11451, Saudi Arabia.
authors: Sobhy M
authors: SM
authors: Yakout
authors: Department of Biochemistry, College of Science, King Saud University Riyadh 11451, Saudi Arabia ; Biomarkers Research Lab, Department of Biochemistry, College of Science, King Saud University Riyadh 11451, Saudi Arabia.
authors: Nasser M Al
authors: NM
authors: Daghri
authors: Department of Biochemistry, College of Science, King Saud University Riyadh 11451, Saudi Arabia.
authors: Abdullah S
authors: AS
authors: Alhomida
authors: Department of Biochemistry, College of Science, King Saud University Riyadh 11451, Saudi Arabia.
authors: Haseeb A
authors: HA
authors: Khan
keywords: Acute myocardial infarction; PAI-1; TPA; thrombotic markers