title: Review of the correlation between results of cytogenetic dosimetry from blood lymphocytes and EPR dosimetry from tooth enamel for victims of radiation accidents.
abstract: The goal of this study was to compare dose estimates from electron paramagnetic resonance (EPR) dosimetry with teeth and cytogenetic dosimetry with blood lymphocytes for 30 victims of radiation accidents. The whole-body exposures estimated by tooth enamel EPR dosimetry were ranging from 0.01 to 9.3 Gy. Study group comprised victims exposed to acute and prolonged irradiation at high and low dose rate in different accidents. Blood samples were taken from each of them for cytogenetic analysis. Aberrations were scored and analysed according to International Atomic Energy Agency (IAEA) guidelines for conventional and FISH analysis. Tooth samples were collected in dental clinics after they had been extracted during ordinary practice. EPR dosimetry was performed according to the IAEA protocol. EPR dosimetry showed good correlation with dosimetry based on chromosomal analysis. All estimations of cytogenetic dose below detection limit coincide with EPR dose estimates within the ranges of uncertainty. The differences between cytogenetic and EPR assays may occur in a case of previous unaccounted exposure, non-homogeneous irradiation and due to contribution to absorbed dose from neutron irradiation.
authors: Medical Radiological Research Center, Koroliova str. 4, Obninsk, Kaluga Region 249036, Russia igor.khvostunov@gmail.com.
authors: I K
authors: IK
authors: Khvostunov
authors: Medical Radiological Research Center, Koroliova str. 4, Obninsk, Kaluga Region 249036, Russia.
authors: A I
authors: AI
authors: Ivannikov
authors: Medical Radiological Research Center, Koroliova str. 4, Obninsk, Kaluga Region 249036, Russia.
authors: V G
authors: VG
authors: Skvortsov
authors: Burnasyan Federal Medical Biophysical Center of the Russian Federal Medical Biological Agency, Zhivopisnaya str. 46, Moscow 123182, Russia.
authors: V Yu
authors: VY
authors: Nugis
authors: Medical Radiological Research Center, Koroliova str. 4, Obninsk, Kaluga Region 249036, Russia.
authors: E V
authors: EV
authors: Golub
mesh_terms: D000328:Adult; D002675:Child, Preschool; D020732:Cytogenetic Analysis / Q000379:methods*; D003743:Dental Enamel / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D018788:Radioactive Hazard Release; D011874:Radiometry / Q000295:instrumentation / Q000379:methods*; D014070:Tooth / Q000528:radiation effects*; D055815:Young Adult