title: Increased CD147 (EMMPRIN) expression in the rat brain following traumatic brain injury.
abstract: The extracellular matrix metalloproteinase inducer (EMMPRIN), or CD147, has been known to play a key regulatory role in vascular permeability and leukocyte activation by inducing the expression of matrix metalloproteinases (MMPs). The effects of traumatic brain injury on the expression of EMMPRIN remain poorly understood. In this study, we investigated changes in EMMPRIN expression in a rat model of fluid percussion injury (FPI) and examined the potential association between EMMPRIN and MMP-9 expression. Adult male rats were subjected to FPI. EMMPRIN expression was markedly up-regulated in the brain tissue surrounding the injured region 6-48 h after TBI, as measured by immunoblot and immunohistochemistry. EMMPRIN expression was localized to inflammatory cells. The increase in EMMPRIN expression was temporally correlated with an increase in MMP-9 levels. These data demonstrate, for the first time, changes in CD147 and MMP-9 expression following TBI. These data also suggest that CD147 and MMP-9 may play a role in vascular injuries after TBI.
authors: Department of Neurosurgery, The Second Hospital, Tianjin Medical University, Tianjin 300211, China; Tianjin Huanhu Hospital, Tianjin 300060, China.
authors: Ming
authors: M
authors: Wei
authors: Department of Neurosurgery, The Second Hospital, Tianjin Medical University, Tianjin 300211, China.
authors: Hong
authors: H
authors: Li
authors: Tianjin Huanhu Hospital, Tianjin 300060, China.
authors: Yanguo
authors: Y
authors: Shang
authors: Tianjin Neurological Institute, General Hospital, Tianjin Medical University, 154 Anshan Road, Tianjin 300052, China.
authors: Ziwei
authors: Z
authors: Zhou
authors: Tianjin Neurological Institute, General Hospital, Tianjin Medical University, 154 Anshan Road, Tianjin 300052, China. Electronic address: jianningzhang@yeah.net.
authors: Jianning
authors: J
authors: Zhang
mesh_terms: D000818:Animals; D051926:Basigin / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D001930:Brain Injuries / Q000378:metabolism*; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D010296:Parietal Lobe / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D051926:Basigin; D020780:Matrix Metalloproteinase 9
keywords: CD147; Immunocytochemistry; MMP-9; Rat; Traumatic brain injury