title: Effect of carbazochrome sodium sulfonate on refractory chronic prostatitis.
abstract: OBJECTIVE
  To study the effect of carbazochrome sodium sulfonate, an agent that reduces capillary permeability, on refractory chronic prostatitis.
  
  
  METHODS
  Patients with prostatitis refractory to at least 8 weeks of routine therapy and with urinalysis positive for microhematuria were considered for the present study. In addition to their prior therapy, the patients received carbazochrome at a dose of 30 mg three times a day. The severity of pain (score 0-10), daytime and night-time frequency, international prostate symptom score, global self-assessment, urine occult blood positivity, and adverse events were assessed after 4 and 8 weeks of treatment, and compared with baseline findings.
  
  
  RESULTS
  A total of 50 patients (mean age 68.6 ± 8.5 years) were evaluable. The pain score decreased significantly from 3.2 ± 2.1 at baseline to 1.7 ± 1.4 after 4 weeks of treatment and to 1.1 ± 1.8 after 8 weeks. Daytime and night-time frequency, storage symptoms, post-micturition symptoms, and urine occult blood positivity also significantly improved. More than 36% of the patients gave a global self-assessment rating of "improved" or "better" after both 4 and 8 weeks of treatment. Mild adverse events occurred in three patients; one had nausea and two developed drug rash.
  
  
  CONCLUSIONS
  Carbazochrome seems to effectively improve pain as well as storage and post-micturition symptoms in patients with refractory chronic prostatitis.
authors: Department of Urology, National Hospital Organization, Kobe Medical Center, Kobe, Hyogo.
authors: Hitoshi
authors: H
authors: Oh-oka
authors: Tetsuo
authors: T
authors: Yamada
authors: Hiromitsu
authors: H
authors: Noto
authors: Tomokazu
authors: T
authors: Umeyama
authors: Katsumi
authors: K
authors: Kadekawa
authors: Katsuhiro
authors: K
authors: Ashitomi
authors: Saori
authors: S
authors: Nishijima
authors: Kimio
authors: K
authors: Sugaya
mesh_terms: D000323:Adrenochrome / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000368:Aged; D002908:Chronic Disease; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011472:Prostatitis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D006490:Hemostatics; D000323:Adrenochrome; C073338:carbazochrome
keywords: capillary permeability; carbazochrome; chronic prostatitis; urine occult blood