title: Neuronal activity-dependent regulation of MicroRNAs.
abstract: MicroRNAs are non-coding short (~23 nucleotides) RNAs that mediate post-transcriptional regulation through sequence-specific gene silencing. The role of miRNAs in neuronal development, synapse formation and synaptic plasticity has been highlighted. However, the role of neuronal activity on miRNA regulation has been less focused. Neuronal activity-dependent regulation of miRNA may fine-tune gene expression in response to synaptic plasticity and memory formation. Here, we provide an overview of miRNA regulation by neuronal activity including high-throughput screening studies. We also discuss the possible molecular mechanisms of activity-dependent induction and turnover of miRNAs.
authors: Department of Brain and Cognitive Sciences, Seoul National University, Seoul 151-747, Korea.
authors: Su-Eon
authors: SE
authors: Sim
authors: Department of Brain and Cognitive Sciences, Seoul National University, Seoul 151-747, Korea.
authors: Joseph
authors: J
authors: Bakes
authors: Department of Brain and Cognitive Sciences, Seoul National University, Seoul 151-747, Korea ; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151-747, Korea.
authors: Bong-Kiun
authors: BK
authors: Kaang
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D057166:High-Throughput Screening Assays; D006801:Humans; D008568:Memory / Q000502:physiology; D035683:MicroRNAs / Q000502:physiology*; D009473:Neuronal Plasticity / Q000235:genetics; D009474:Neurons / Q000502:physiology*; D034622:RNA Interference
chemical_list: D035683:MicroRNAs
keywords: NMDAR; high-throughput screening; miRNA induction; miRNA turnover; neuronal activity