title: Use of apixaban for an elderly patient with left atrial thrombus.
abstract: An 86-year-old man had long-standing persistent atrial fibrillation, but had not received any anticoagulants. Transthoracic echocardiography revealed a large thrombus formation in the left atrium. We hesitated to use the conventional anticoagulant, warfarin, because he was very old and had dementia. We decided to resolve the thrombus at our outpatient clinic. He was started on the novel oral anticoagulant, apixaban, 2.5 mg twice daily, which is a direct factor Xa (FXa) inhibitor. After 11 weeks on that therapy, the thrombus formation had almost resolved. During oral anticoagulant therapy, no serious bleeding complications, systemic embolisms or strokes were noted. To the best of our knowledge, we are the first to report that apixaban (5 mg/day) can possibly resolve a thrombus formation in the left atrium.
authors: Department of Cardiovascular Medicine, Toho University Faculty of Medicine, Tokyo, Japan.
authors: Shintaro
authors: S
authors: Dobashi
authors: Department of Cardiovascular Medicine, Toho University Faculty of Medicine, Tokyo, Japan.
authors: Tadashi
authors: T
authors: Fujino
authors: Department of Cardiovascular Medicine, Toho University Faculty of Medicine, Tokyo, Japan.
authors: Takanori
authors: T
authors: Ikeda
mesh_terms: D000369:Aged, 80 and over; D000925:Anticoagulants / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000150:complications; D004452:Echocardiography; D006325:Heart Atria; D006331:Heart Diseases / Q000188:drug therapy*; D006801:Humans; D008297:Male; D011720:Pyrazoles / Q000627:therapeutic use*; D011728:Pyridones / Q000627:therapeutic use*; D013927:Thrombosis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D011720:Pyrazoles; D011728:Pyridones; C522181:apixaban