title: [Bone metabolism and cardiovascular function update. Relationship between immune and vascular system in bone tissues].
abstract: Bone marrow is a highly vascularized organ and the vessel walls have a large number of fenestrations. Various kinds of hematopoietic cells are continuously entering into and egressing from bone marrow cavity through these unique features. Monocytoid osteoclast precursors also migrate across the capillary endothelium, serving as a dynamic point of control of bone homeostasis. We have recently revealed the cellular dynamics of monocytoid osteoclast precursors in vivo by a novel fluorescent imaging technology. Furthermore we found the regulatory mechanism of vascular permeability in bone marrow in vivo by using intravital multiphoton microscopy. Here we show the latest data and also discuss its further application.
authors: Department of Immunology and Cell Biology, Graduate School of Medicine, Osaka University, Japan./Japan Science and Technology Agency, CREST.
authors: Junichi
authors: J
authors: Kikuta
authors: Masaru
authors: M
authors: Ishii
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000276:immunology / Q000378:metabolism; D001842:Bone and Bones / Q000276:immunology / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007107:Immune System; D010010:Osteoclasts / Q000378:metabolism; D053245:RANK Ligand / Q000378:metabolism
chemical_list: D053245:RANK Ligand