title: Endoglin (CD105) is a useful marker for evaluating microvessel density and predicting prognosis in esophageal squamous cell carcinoma.
abstract: BACKGROUND
  Angiogenic molecular markers such as vascular endothelial growth factor and tumor microvessel density reflect prognosis of human cancers. The present study clarified the usefulness of endothelial marker endoglin (CD 105) by assessing microvessel density in esophageal squamous cell carcinoma (ESCC).
  
  
  METHODS
  We immunohistochemically investigated CD105, CD31, and vascular endothelial growth factor-A VEGF-A expression in primary esophageal squamous cell carcinoma specimens from 142 patients.
  
  
  RESULTS
  Microvessel density was 35.9±21.2 for CD105 and 46.3±25.4 for CD31. CD105 microvessel density was significantly associated with tumor length, tumor invasion depth, lymph node metastasis, stage, lymphatic invasion, venous invasion, and VEGF-A expression; its correlation with almost all clinicopathological parameters was stronger than CD31 microvessel density. And significantly better prognosis was achieved in patients with low, compared to high CD105, microvessel density.
  
  
  CONCLUSIONS
  CD105 microvessel density reflected the degree of angiogenesis and prognosis in patients with esophageal squamous cell carcinoma.
authors: Department of Digestive Surgery, Breast and Thyroid Surgery Graduate School of Medical Sciences, Kagoshima University, Sakuragaoka, Kagoshima, Japan.
authors: Toshihide
authors: T
authors: Sakurai
authors: Department of Digestive Surgery, Breast and Thyroid Surgery Graduate School of Medical Sciences, Kagoshima University, Sakuragaoka, Kagoshima, Japan hokumura@m.kufm.kagoshima-u.ac.jp.
authors: Hiroshi
authors: H
authors: Okumura
authors: Department of Digestive Surgery, Breast and Thyroid Surgery Graduate School of Medical Sciences, Kagoshima University, Sakuragaoka, Kagoshima, Japan.
authors: Masataka
authors: M
authors: Matsumoto
authors: Department of Digestive Surgery, Breast and Thyroid Surgery Graduate School of Medical Sciences, Kagoshima University, Sakuragaoka, Kagoshima, Japan.
authors: Yasuto
authors: Y
authors: Uchikado
authors: Department of Digestive Surgery, Breast and Thyroid Surgery Graduate School of Medical Sciences, Kagoshima University, Sakuragaoka, Kagoshima, Japan.
authors: Tetsuhiro
authors: T
authors: Owaki
authors: Department of Digestive Surgery, Breast and Thyroid Surgery Graduate School of Medical Sciences, Kagoshima University, Sakuragaoka, Kagoshima, Japan.
authors: Yoshiaki
authors: Y
authors: Kita
authors: Department of Digestive Surgery, Breast and Thyroid Surgery Graduate School of Medical Sciences, Kagoshima University, Sakuragaoka, Kagoshima, Japan.
authors: Tetsuro
authors: T
authors: Setoyama
authors: Department of Digestive Surgery, Breast and Thyroid Surgery Graduate School of Medical Sciences, Kagoshima University, Sakuragaoka, Kagoshima, Japan.
authors: Itaru
authors: I
authors: Omoto
authors: Department of Digestive Surgery, Breast and Thyroid Surgery Graduate School of Medical Sciences, Kagoshima University, Sakuragaoka, Kagoshima, Japan.
authors: Yuko
authors: Y
authors: Kijima
authors: Department of Digestive Surgery, Breast and Thyroid Surgery Graduate School of Medical Sciences, Kagoshima University, Sakuragaoka, Kagoshima, Japan.
authors: Sumiya
authors: S
authors: Ishigami
authors: Department of Digestive Surgery, Breast and Thyroid Surgery Graduate School of Medical Sciences, Kagoshima University, Sakuragaoka, Kagoshima, Japan.
authors: Shoji
authors: S
authors: Natsugoe
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000096:biosynthesis*; D014408:Biomarkers, Tumor / Q000096:biosynthesis; D002294:Carcinoma, Squamous Cell / Q000098:blood supply* / Q000378:metabolism / Q000473:pathology; D000071063:Endoglin; D004938:Esophageal Neoplasms / Q000098:blood supply* / Q000378:metabolism / Q000473:pathology; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000473:pathology; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000096:biosynthesis; D011379:Prognosis; D011956:Receptors, Cell Surface / Q000096:biosynthesis*; D012189:Retrospective Studies; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; C064206:ENG protein, human; D000071063:Endoglin; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D011956:Receptors, Cell Surface; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A
keywords: CD31; Endoglin (CD105); esophageal cancer; vascular endothelial growth factor