title: Duodeno-jejunal tube placement in an experimental model of obesity: effects on food behaviour and basal energy expenditure.
abstract: BACKGROUND
  Metabolic surgery can modulate weight as well as food intake and basal energy expenditure. In this study, we evaluate the effectiveness of duodenal exclusion by analysing anthropometric results, intake variations, food behaviour and calorimetric parameters.
  
  
  METHODS
  This is an experimental study with 8-week-old Sprague-Dawley male rats. The sequences used are as follows: Cafeteria diet for 3 weeks, followed by surgery and sacrifice at 4 weeks. Four experimental groups are as follows: two non-obese groups (n = 15; surgery = 10, sham = 5) and two obese groups by cafeteria diet (n = 15; surgery = 10, sham = 5). Surgery performed was duodenal exclusion with physical barrier. Weight, intake, glycaemia and basal energy expenditure by indirect calorimetry were monitored before and after surgery.
  
  
  RESULTS
  Weight changes in groups that underwent intervention were significant. The reduction in calorie consumption after surgery was significant in the obese intervention group despite an increased standard feed consumption (161 ± 11 vs 139 ± 13 Kcal/day, p < 0.05; due to a lower consumption of cafeteria diet). In non-obese animals, changes were transient. Basal energy expenditure decreased in both intervention groups: 6.2 ± 0.5 vs 5.5 ± 0.4 Kcal/kg/h in non-obese animals and 5.6 ± 0.3 vs 4.7 ± 0.3 Kcal/kg/h in obese animals (p < 0.05).
  
  
  CONCLUSIONS
  Duodeno-jejunal tube placement stops weight gain in obese and non-obese animals. In obese animals, there is an important qualitative change in appetite towards standard feed with a significant decrease in caloric intake. In non-obese animals, changes in quantitative intake are transient. This surgery decreases basal energy expenditure in obese animals. This may be attributed to an enhanced thermogenic effect of food and a slowing in the animal's weight gain.
authors: Surgery Unit of the Faculty of Medicine and Health Sciences, Rovira i Virgili University, Reus, Tarragona, Spain, fatima.sabench@urv.cat.
authors: Fàtima
authors: F
authors: Sabench Pereferrer
authors: Margarida
authors: M
authors: Vives Espelta
authors: Arantxa
authors: A
authors: Cabrera Vilanova
authors: Mercè
authors: M
authors: Hernández González
authors: Albert
authors: A
authors: Feliu Rovira
authors: Santiago
authors: S
authors: Blanco Blasco
authors: Alicia
authors: A
authors: Molina López
authors: Raul
authors: R
authors: Beltrán Nebot
authors: Jorge
authors: J
authors: Joven Maried
authors: Daniel
authors: D
authors: Del Castillo Déjardin
mesh_terms: D000818:Animals; D050110:Bariatric Surgery / Q000379:methods*; D001835:Body Weight; D002153:Calorimetry, Indirect; D004195:Disease Models, Animal; D004386:Duodenum / Q000473:pathology / Q000601:surgery*; D002149:Energy Intake; D004734:Energy Metabolism; D005247:Feeding Behavior; D007583:Jejunum / Q000473:pathology / Q000601:surgery*; D008297:Male; D009765:Obesity / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015430:Weight Gain / Q000502:physiology