title: Inherent anchorages in UiO-66 nanoparticles for efficient capture of alendronate and its mediated release.
abstract: Zr-based MOF nanoparticles were applied as efficient carriers for alendronate delivery, and an unprecedented drug loading capacity was achieved thanks to the inherent drug anchorages of Zr-O clusters therein. The encapsulated drug featured with a pH-dependent release profile, and inhibited the growth of cancer cells more efficiently than the free drug.
authors: Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China. jinlougu@ecust.edu.cn.
authors: Xiangyang
authors: X
authors: Zhu
authors: Jinlou
authors: J
authors: Gu
authors: Yao
authors: Y
authors: Wang
authors: Bing
authors: B
authors: Li
authors: Yongsheng
authors: Y
authors: Li
authors: Wenru
authors: W
authors: Zhao
authors: Jianlin
authors: J
authors: Shi
mesh_terms: D019386:Alendronate / Q000008:administration & dosage* / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry*; D050071:Bone Density Conservation Agents / Q000008:administration & dosage* / Q000737:chemistry*; D045744:Cell Line, Tumor; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D005434:Flow Cytometry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D053758:Nanoparticles / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D010316:Particle Size; D014961:X-Ray Diffraction; D015040:Zirconium / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D050071:Bone Density Conservation Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D009942:Organometallic Compounds; D015040:Zirconium; D019386:Alendronate