title: Plexin a4 expression in adult rat cranial nerves.
abstract: PlexinsA1-A4 participate in class 3 semaphorin signaling as co-receptors to neuropilin 1 and 2. PlexinA4 is the latest member of the PlexinA subfamily to be identified. In previous studies, we described the expression of PlexinA4 in the brain and spinal cord of the adult rat. Here, antibodies to PlexinA4 were used to reveal immunolabeling in most of the cranial nerve surveyed. Labeling was found in the olfactory, optic, oculomotor, trochlear, trigeminal, abducens, facial, vestibulocochlear, glossopharyngeal, vagus, and hypoglossal nerves. This is the first detailed description of the cellular and subcellular distribution of PlexinA4 in the adult cranial nerves. The findings will set the basis for future studies on the potential role of PlexinA4 in regeneration and repair of the adult central and peripheral nervous system.
authors: Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA, USA. Electronic address: cguteku@emory.edu.
authors: Claire-Anne
authors: CA
authors: Gutekunst
authors: Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA, USA; Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA; Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA. Electronic address: rgross@emory.edu.
authors: Robert E
authors: RE
authors: Gross
mesh_terms: D000818:Animals; D003391:Cranial Nerves / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D009419:Nerve Tissue Proteins / Q000032:analysis / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011956:Receptors, Cell Surface / Q000032:analysis / Q000096:biosynthesis*
chemical_list: D009419:Nerve Tissue Proteins; C575033:Plxna4 protein, rat; D011956:Receptors, Cell Surface
keywords: Axon guidance molecule; Cranial nerve; Plexa4; PlexinA4; Plxna4; Protein distribution; Semaphorin