title: Vaccination against δ-retroviruses: the bovine leukemia virus paradigm.
abstract: Bovine leukemia virus (BLV) and human T-lymphotropic virus type 1 (HTLV-1) are closely related d-retroviruses that induce hematological diseases. HTLV-1 infects about 15 million people worldwide, mainly in subtropical areas. HTLV-1 induces a wide spectrum of diseases (e.g., HTLV-associated myelopathy/tropical spastic paraparesis) and leukemia/lymphoma (adult T-cell leukemia). Bovine leukemia virus is a major pathogen of cattle, causing important economic losses due to a reduction in production, export limitations and lymphoma-associated death. In the absence of satisfactory treatment for these diseases and besides the prevention of transmission, the best option to reduce the prevalence of d-retroviruses is vaccination. Here, we provide an overview of the different vaccination strategies in the BLV model and outline key parameters required for vaccine efficacy.
authors: Instituto de Virología, Centro de Investigaciones en Ciencias Veterinarias y Agronómicas, INTA, C.C. 1712, Castelar, Argentina. gutierrez.geronimo@inta.gob.ar.
authors: Gerónimo
authors: G
authors: Gutiérrez
authors: Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (Gembloux Agro-Bio Tech), University of Liège (ULg), 4000 Liège, Belgium. sabrirodriguez@hotmail.com.
authors: Sabrina M
authors: SM
authors: Rodríguez
authors: Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (Gembloux Agro-Bio Tech), University of Liège (ULg), 4000 Liège, Belgium. arsene.burny@guest.ulg.ac.be.
authors: Alix
authors: A
authors: de Brogniez
authors: Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (Gembloux Agro-Bio Tech), University of Liège (ULg), 4000 Liège, Belgium. n.gillet@ulg.ac.be.
authors: Nicolas
authors: N
authors: Gillet
authors: Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (Gembloux Agro-Bio Tech), University of Liège (ULg), 4000 Liège, Belgium. ramugolime@gmail.com.
authors: Ramarao
authors: R
authors: Golime
authors: Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (Gembloux Agro-Bio Tech), University of Liège (ULg), 4000 Liège, Belgium. arsene.burny@guest.ulg.ac.be.
authors: Arsène
authors: A
authors: Burny
authors: Instituto de Virología, Centro de Investigaciones en Ciencias Veterinarias y Agronómicas, INTA, C.C. 1712, Castelar, Argentina. jaworski.juan@inta.gob.ar.
authors: Juan-Pablo
authors: JP
authors: Jaworski
authors: Instituto de Virología, Centro de Investigaciones en Ciencias Veterinarias y Agronómicas, INTA, C.C. 1712, Castelar, Argentina. alvarez.irene@inta.gob.ar.
authors: Irene
authors: I
authors: Alvarez
authors: Instituto de Virología, Centro de Investigaciones en Ciencias Veterinarias y Agronómicas, INTA, C.C. 1712, Castelar, Argentina. vagnoni.lucas@inta.gob.ar.
authors: Lucas
authors: L
authors: Vagnoni
authors: Instituto de Virología, Centro de Investigaciones en Ciencias Veterinarias y Agronómicas, INTA, C.C. 1712, Castelar, Argentina. trono.karina@inta.gob.ar.
authors: Karina
authors: K
authors: Trono
authors: Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (Gembloux Agro-Bio Tech), University of Liège (ULg), 4000 Liège, Belgium. luc.willems@ulg.ac.be.
authors: Luc
authors: L
authors: Willems
mesh_terms: D000818:Animals; D057134:Antibodies, Neutralizing / Q000276:immunology; D000914:Antibodies, Viral / Q000276:immunology; D002417:Cattle; D017977:Deltaretrovirus / Q000276:immunology* / Q000502:physiology; D006800:Deltaretrovirus Infections / Q000517:prevention & control* / Q000821:virology; D016583:Enzootic Bovine Leukosis / Q000517:prevention & control / Q000821:virology; D015490:HTLV-I Infections / Q000517:prevention & control; D015368:Human T-lymphotropic virus 1 / Q000276:immunology / Q000502:physiology; D006801:Humans; D001909:Leukemia Virus, Bovine / Q000276:immunology / Q000502:physiology; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D014613:Vaccines, Attenuated; D014765:Viral Vaccines