title: Effect of the Y chromosome on plasma high-density lipoprotein-cholesterol levels in Y-chromosome-consomic mouse strains.
abstract: BACKGROUND
  Plasma high-density lipoprotein (HDL)-cholesterol level is a clinically important quantitative phenotype that widely varies among inbred mouse strains. Several genes or loci associated with plasma HDL-cholesterol levels have been identified on autosomes and the X chromosome. In contrast, genes or loci on the Y chromosome have not attracted significant attention hitherto. Therefore, we investigated the effects of the Y chromosome on plasma HDL-cholesterol levels in Y- chromosome-consomic (Y-consomic) mouse strains.
  
  
  RESULTS
  Plasma HDL-cholesterol level data from 16 Y-consomic strains demonstrated that the Y chromosome substitutions significantly altered plasma HDL-cholesterol levels, i.e., variations in the plasma HDL-cholesterol level could be partially explained by Y chromosome genes. We obtained the following results from the genotype data on 30 single nucleotide polymorphisms (SNPs), including nonsynonymous and synonymous SNPs and 9 polymorphisms in Sry: (1) Variation in rs46947134 of Uty was significantly associated with plasma HDL-cholesterol levels. (2) A CAG repeat number polymorphism in Sry was significantly associated with plasma HDL-cholesterol levels. (3) Strains with a certain haplotype of the Mus musculus domesticus-type Y chromosome had significantly lower plasma HDL-cholesterol levels than strains with a certain haplotype of the M. m. musculus-type Y chromosome.
  
  
  CONCLUSIONS
  The effect of the Y chromosome on plasma HDL-cholesterol levels was confirmed in the Y-consomic strains. We identified several variants associated with plasma HDL-cholesterol levels. Because the physiological significance of various Y-linked genes remains unclear, the results of this study will provide further insights into the functions of Y-linked genes in lipid metabolism.
authors: Agrogenomics Research Center, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8634, Japan. jsuto@affrc.go.jp.
authors: Jun-ichi
authors: J
authors: Suto
authors: Kunio
authors: K
authors: Satou
mesh_terms: D000818:Animals; D008076:Cholesterol, HDL / Q000097:blood*; D003433:Crosses, Genetic; D005260:Female; D050173:Genes, Y-Linked / Q000235:genetics*; D024282:Genes, sry / Q000235:genetics; D005838:Genotype; D006239:Haplotypes; D040582:Inheritance Patterns / Q000235:genetics; D008297:Male; D008815:Mice, Inbred Strains; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D014998:Y Chromosome / Q000235:genetics*
chemical_list: D008076:Cholesterol, HDL