title: [Expression and significance of ERalpha mRNA of residents exposed to arsenic via drinking water].
abstract: OBJECTIVE
  To detect ERbeta mRNA expression of subjects exposed to different arsenic drinking water, and to analyze the potential relationship between their abnormal expression and heart injury caused by arsenic in order to study the endocrine disturbing effect of arsenic.
  
  
  METHODS
  Molecular epidemiological method was used. The study subjects included a total of 273 residents exposed to arsenic via drinking water,and they were divided into four groups according to arsenic concentration, and their blood ERbeta mRNA expression was detected by real-time RT-PCR.
  
  
  RESULTS
  The level of ERbeta mRNA expression rose with increasing of water As and urine As (r = 0.159, 0.21, P < 0.05). The prevalence of Q-Tc interval prolongation aggravated with increasing of water As(chi2 = 4.35, P = 0.037), while according with the variation of ERbeta mRNA expression. Tp-Te interval prolonged with increasing of water As (r = 0.199, P = 0.023), as well prolonged with increasing of ERbeta mRNA expression (r = 0.205, P = 0.019). The prevalence of arrhythmia was almost according with the variation of ERbeta mRNA expression.
  
  
  CONCLUSIONS
  chronic arsenic exposure can potentially disturb ERbeta mRNA expression, as well as there are possible relationship between ERbeta mRNA abnormal expression and Q-Tc interval prolongation and Tp-Te interval prolonged caused by arsenic.
authors: Xiaohong
authors: X
authors: Han
authors: Zhiwei
authors: Z
authors: Guo
authors: Weihong
authors: W
authors: Yang
authors: Kegong
authors: K
authors: Wu
authors: Yanhong
authors: Y
authors: Li
authors: Yajuan
authors: Y
authors: Xia
mesh_terms: D001145:Arrhythmias, Cardiac; D001151:Arsenic / Q000633:toxicity*; D060766:Drinking Water / Q000737:chemistry; D004781:Environmental Exposure; D047628:Estrogen Receptor alpha / Q000096:biosynthesis*; D047629:Estrogen Receptor beta; D006801:Humans; D015995:Prevalence; D012333:RNA, Messenger
chemical_list: D060766:Drinking Water; C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D012333:RNA, Messenger; D001151:Arsenic