title: [Bone metabolism and cardiovascular function update. Effects of antiosteoporotic agents on glucose and lipid metabolism].
abstract: At present, antiosteoporotic agents that might affect glucose and/or lipid metabolism include bisphosphonates, Selective Estrogen Receptor Modulators ; SERMs and activated vitamin D. Bisphosphonates have little, if any, effect on lipid metabolism, while they are suggested to improve glucose metabolism, via osteocalcin or adiponectin. SERMs are shown to decrease serum triglycerides and LDL cholesterol levels, and increase HDL cholesterol level. To date, SERMs are not proven to reduce the risk of coronary events. From nutritional point of view, studies suggest that vitamin D may improve lipid and glucose metabolism, whereas its therapeutic effect on lifestyle related diseases is unknown.
authors: Division of Endocrinology and Metabolism, Kanto Central Hospital, Tokyo, Japan.
authors: Mai
authors: M
authors: Kondo
authors: Yuzo
authors: Y
authors: Mizuno
mesh_terms: D001842:Bone and Bones / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects*; D010024:Osteoporosis / Q000188:drug therapy* / Q000378:metabolism; D020845:Selective Estrogen Receptor Modulators / Q000627:therapeutic use*; D014807:Vitamin D / Q000378:metabolism
chemical_list: D020845:Selective Estrogen Receptor Modulators; D014807:Vitamin D; D005947:Glucose