title: Intralipid emulsion treatment as an antidote in lipophilic drug intoxications.
abstract: Intravenous lipid emulsion (ILE) is a lifesaving treatment of lipophilic drug intoxications. Not only does ILE have demonstrable efficacy as an antidote to local anesthetic toxicity, it is also effective in lipophilic drug intoxications. Our case series involved 10 patients with ingestion of different types of lipophilic drugs. Intravenous lipid emulsion treatment improved Glasgow Coma Scale or blood pressure and pulse rate or both according to the drug type. Complications were observed in 2 patients (minimal change pancreatitis and probable ILE treatment-related fat infiltration in lungs). In our case series, ILE was used for different lipophilic drug intoxications to improve cardiovascular and neurologic symptoms. According to the results, it was found that ILE treatment is a lifesaving agent in lipophilic drug intoxications and it can be used in unconscious patients who have cardiac and/or neurologic symptoms but no history of a specific drug ingestion.
authors: Department of Emergency Medicine, Umraniye Training and Research Hospital, Istanbul, Turkey. Electronic address: sebnemec@gmail.com.
authors: Sebnem
authors: S
authors: Eren Cevik
authors: Department of Emergency Medicine, Umraniye Training and Research Hospital, Istanbul, Turkey.
authors: Tanju
authors: T
authors: Tasyurek
authors: Department of Emergency Medicine, Dr Lutfi Kirdar Kartal Education and Research Hospital, Istanbul, Turkey.
authors: Ozlem
authors: O
authors: Guneysel
mesh_terms: D000293:Adolescent; D000328:Adult; D000525:Alprazolam / Q000506:poisoning; D000639:Amitriptyline / Q000037:antagonists & inhibitors / Q000506:poisoning*; D000931:Antidotes / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D003987:Dibenzothiazepines / Q000506:poisoning*; D062787:Drug Overdose / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D005217:Fat Emulsions, Intravenous / Q000627:therapeutic use*; D005260:Female; D005473:Fluoxetine / Q000506:poisoning*; D015600:Glasgow Coma Scale; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D000077213:Lamotrigine; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D008790:Metoprolol / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000506:poisoning; D008875:Middle Aged; D009543:Nifedipine / Q000506:poisoning; D000069348:Quetiapine Fumarate; D014227:Triazines / Q000506:poisoning*; D055815:Young Adult
chemical_list: D000931:Antidotes; D003987:Dibenzothiazepines; D005217:Fat Emulsions, Intravenous; D014227:Triazines; D005473:Fluoxetine; D000639:Amitriptyline; D000069348:Quetiapine Fumarate; D008790:Metoprolol; D009543:Nifedipine; D000077213:Lamotrigine; D000525:Alprazolam