title: Raised concentrations of lipid peroxidation products (LPO) in pregnant women with impaired glucose tolerance.
abstract: BACKGROUND
  Lipid peroxidation (LPO) results from oxidative damage to membrane lipids. Whereas LPO rises in normal pregnancy, the effect of gestational diabetes mellitus (GDM) on this process has not been clearly defined.
  
  
  METHODS
  Fasting blood concentrations of malondialdehyde+4-hydroxyalkenals (MDA+4-HDA), as LPO index, TNFa soluble receptors (sTNF-R1 and sTNF-R2), and soluble adhesion molecules (sICAM-1, sVCAM-1), were measured in 51 women at 28 weeks of gestation. The women were divided according to the results of 50.0 g glucose challenge test (GCT) and 75.0 g oral glucose tolerance test (OGTT): Controls (n=20), normal responses to both GCT and OGTT; Intermediate Group (IG) (n=15), abnormal GCT but normal OGTT; GDM group (n=16), abnormal both GCT and OGTT.
  
  
  RESULTS
  Glucose concentrations in women diagnosed with GDM were within the range of impaired glucose tolerance. There were no significant differences in concentrations of either TNF a soluble receptors R1 and R2, or sICAM-1 or sVCAM-1. LPO concentrations [MDA+4-HDA (nmol/mg protein)] were significantly higher in women with GDM than in the other two groups [64.1±24.3 (mean±SD), 39.3±23.1, 47.0±18.1, for GDM, IG and Controls, respectively; p<0.05]. In multivariate analysis, the only significant independent correlation was between LPO level and glucose at 120 minutes of OGTT (rs=0.42; p=0.009).
  
  
  CONCLUSIONS
  Oxidative damage to membrane lipids is increased in GDM and might result directly from hyperglycaemia. Physiological significance of this phenomenon remains to be elucidated.
authors: Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, Lodz, Poland, Department of Endocrinology and Metabolic Diseases, Polish Mother's Memorial Hospital - Research Institute, Lodz, Poland.
authors: Krzysztof C
authors: KC
authors: Lewandowski
authors: Department of Diabetes and Endocrinology, Royal Free Hospital, Hampstead, London, UK.
authors: Nemanja
authors: N
authors: Stojanovic
authors: Department of Diabetes and Endocrinology, Royal Free Hospital, Hampstead, London, UK.
authors: Martin
authors: M
authors: Press
authors: Department of Obstetrics and Gynaecology, Royal Free Hospital, Hampstead, London, UK.
authors: Susan
authors: S
authors: Tuck
authors: Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, Lodz, Poland, Department of Endocrinology and Metabolic Diseases, Polish Mother's Memorial Hospital - Research Institute, Lodz, Poland.
authors: Andrzej
authors: A
authors: Lewiński
authors: Department of Endocrinology and Metabolic Diseases, Polish Mother's Memorial Hospital - Research Institute, Lodz, Poland, Department of Oncological Endocrinology, Medical University of Lodz, Lodz, Poland.
authors: Małgorzata
authors: M
authors: Karbownik-Lewińska
mesh_terms: D000328:Adult; D015815:Cell Adhesion Molecules / Q000378:metabolism; D003430:Cross-Sectional Studies; D016640:Diabetes, Gestational / Q000097:blood / Q000378:metabolism; D005260:Female; D018149:Glucose Intolerance / Q000097:blood*; D006801:Humans; D007333:Insulin Resistance; D015227:Lipid Peroxidation; D008131:London; D011044:Poland; D011247:Pregnancy; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism
chemical_list: D015815:Cell Adhesion Molecules; D018124:Receptors, Tumor Necrosis Factor