title: Resveratrol protects against cigarette smoke-induced oxidative damage and pulmonary inflammation.
abstract: This study was carried out to investigate the effects of resveratrol on cigarette smoke (CS)-induced lung injury. Experimental mice were administrated with 1 mg/kg or 3 mg/ kg resveratrol orally, 1 h prior to CS exposure (five cigarettes a day for 3 consecutive days). Airway inflammation and gene expression changes were assessed. CS exposure increased the number of pulmonary inflammatory cells, coupled with elevated production of tumor necrosis factor α and interleukin-6 in bronchoalveolar lavage fluids. Resveratrol treatment decreased CS-induced lung inflammation. Resveratrol restored the activities of superoxide dismutase, GSH peroxidase, and catalase in CS-treated mice. CS significantly enhanced the nuclear translocation of nuclear factor κB (NF-κB) and NF-κB DNA binding activity, which was impaired by resveratrol pretreatment. In addition, resveratrol promoted CS-induced heme oxygenase-1 (HO-1) expression and activation. Our results collectively indicate that resveratrol attenuates CS-induced lung oxidative injury, which involves decreased NF-κB activity and the elevated HO-1 expression and activity.
authors: Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China. wangjing2012k@163.com.
authors: Hong
authors: H
authors: Liu
authors: JianZhuang
authors: J
authors: Ren
authors: Hongjie
authors: H
authors: Chen
authors: Yongjie
authors: Y
authors: Huang
authors: Haiyan
authors: H
authors: Li
authors: Zhao
authors: Z
authors: Zhang
authors: Jing
authors: J
authors: Wang
mesh_terms: D000818:Animals; D001992:Bronchoalveolar Lavage Fluid; D002374:Catalase / Q000378:metabolism; D005260:Female; D015870:Gene Expression / Q000187:drug effects; D005979:Glutathione Peroxidase / Q000378:metabolism; D051547:Heme Oxygenase-1 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D055370:Lung Injury / Q000209:etiology / Q000517:prevention & control*; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D016328:NF-kappa B / Q000378:metabolism; D011014:Pneumonia / Q000139:chemically induced / Q000201:enzymology / Q000378:metabolism / Q000517:prevention & control*; D000077185:Resveratrol; D012906:Smoke / Q000009:adverse effects*; D013267:Stilbenes / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000378:metabolism; D014026:Nicotiana; D051996:Transcription Factor RelA / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D015850:Interleukin-6; D008565:Membrane Proteins; D016328:NF-kappa B; C498144:Rela protein, mouse; D012906:Smoke; D013267:Stilbenes; D051996:Transcription Factor RelA; D014409:Tumor Necrosis Factor-alpha; D002374:Catalase; D005979:Glutathione Peroxidase; D051547:Heme Oxygenase-1; C496542:Hmox1 protein, mouse; D013482:Superoxide Dismutase; D000077185:Resveratrol
keywords: Cigarette Smoke; Heme Oxygenase-1 (HO-1); Lung Oxidative Injury; Nuclear Factor-κB (NF-κB); Resveratrol