title: Tramadol toxicity in a cat: case report and literature review of serotonin syndrome.
abstract: BACKGROUND
  Tramadol toxicity has not previously been reported in a cat.
  
  
  METHODS
  This report describes the clinical signs, diagnosis and treatment of tramadol toxicity, manifesting as serotonin syndrome, in a cat in Australia.
  
  
  BACKGROUND
  For any cat with suspicion of serotonin syndrome, in particular secondary to tramadol overdose, it is recommended that decontamination, monitoring and supportive care are instituted as soon as clinical signs develop. Prolonged hospitalisation may be required in the event of a severe overdose.
  
  
  METHODS
  The literature relating to the pharmacology of tramadol and tramadol overdose, clinical manifestations of tramadol overdose, and serotonin syndrome in cats, humans and dogs is reviewed. Recommended treatment for tramadol overdose and serotonin syndrome is also discussed.
authors: Animal Accident and Emergency, Melbourne, Victoria, Australia y.indrawirawan@animalemergency.com.au.
authors: Yenny
authors: Y
authors: Indrawirawan
authors: Animal Accident and Emergency, Melbourne, Victoria, Australia.
authors: Trudi
authors: T
authors: McAlees
mesh_terms: D000701:Analgesics, Opioid / Q000506:poisoning*; D000818:Animals; D001315:Australia; D002371:Cat Diseases / Q000139:chemically induced / Q000175:diagnosis* / Q000188:drug therapy; D002415:Cats; D004285:Dogs; D062787:Drug Overdose / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D006801:Humans; D008508:Medication Errors / Q000662:veterinary*; D020230:Serotonin Syndrome / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D014147:Tramadol / Q000506:poisoning*
chemical_list: D000701:Analgesics, Opioid; D014147:Tramadol