title: Event-Related Potential, Time-frequency, and Functional Connectivity Facets of Local and Global Auditory Novelty Processing: An Intracranial Study in Humans.
abstract: Auditory novelty detection has been associated with different cognitive processes. Bekinschtein et al. (2009) developed an experimental paradigm to dissociate these processes, using local and global novelty, which were associated, respectively, with automatic versus strategic perceptual processing. They have mostly been studied using event-related potentials (ERPs), but local spiking activity as indexed by gamma (60-120 Hz) power and interactions between brain regions as indexed by modulations in beta-band (13-25 Hz) power and functional connectivity have not been explored. We thus recorded 9 epileptic patients with intracranial electrodes to compare the precise dynamics of the responses to local and global novelty. Local novelty triggered an early response observed as an intracranial mismatch negativity (MMN) contemporary with a strong power increase in the gamma band and an increase in connectivity in the beta band. Importantly, all these responses were strictly confined to the temporal auditory cortex. In contrast, global novelty gave rise to a late ERP response distributed across brain areas, contemporary with a sustained power decrease in the beta band (13-25 Hz) and an increase in connectivity in the alpha band (8-13 Hz) within the frontal lobe. We discuss these multi-facet signatures in terms of conscious access to perceptual information.
authors: INSERM U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Equipe PICNIC Paris 75013, France.
authors: Imen
authors: I
authors: El Karoui
authors: INSERM U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Equipe PICNIC Paris 75013, France Cognitive Neuroimaging Unit, INSERM U992, Gif-sur-Yvette 91191, France NeuroSpin Center, Institute of BioImaging, Commissariat à l'Energie Atomique, Gif-sur-Yvette 91191, France.
authors: Jean-Remi
authors: JR
authors: King
authors: INSERM U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Equipe PICNIC Paris 75013, France Cognitive Neuroimaging Unit, INSERM U992, Gif-sur-Yvette 91191, France NeuroSpin Center, Institute of BioImaging, Commissariat à l'Energie Atomique, Gif-sur-Yvette 91191, France.
authors: Jacobo
authors: J
authors: Sitt
authors: INSERM U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Equipe PICNIC Paris 75013, France.
authors: Florent
authors: F
authors: Meyniel
authors: INSERM U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Equipe PICNIC Paris 75013, France Cognitive Neuroimaging Unit, INSERM U992, Gif-sur-Yvette 91191, France NeuroSpin Center, Institute of BioImaging, Commissariat à l'Energie Atomique, Gif-sur-Yvette 91191, France.
authors: Simon
authors: S
authors: Van Gaal
authors: INSERM U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Equipe PICNIC Paris 75013, France AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Neurophysiology, Paris 75013, France.
authors: Dominique
authors: D
authors: Hasboun
authors: AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Neurology, Paris 75013, France.
authors: Claude
authors: C
authors: Adam
authors: INSERM U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Equipe PICNIC Paris 75013, France Cognitive Neuroimaging Unit, INSERM U992, Gif-sur-Yvette 91191, France AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Neurology, Paris 75013, France.
authors: Vincent
authors: V
authors: Navarro
authors: AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Neurology, Paris 75013, France.
authors: Michel
authors: M
authors: Baulac
authors: Cognitive Neuroimaging Unit, INSERM U992, Gif-sur-Yvette 91191, France NeuroSpin Center, Institute of BioImaging, Commissariat à l'Energie Atomique, Gif-sur-Yvette 91191, France Université Paris 11, Orsay 91400, France Collège de France, Paris 75005, France.
authors: Stanislas
authors: S
authors: Dehaene
authors: INSERM U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Equipe PICNIC Paris 75013, France AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Neurology, Paris 75013, France.
authors: Laurent
authors: L
authors: Cohen
authors: INSERM U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Equipe PICNIC Paris 75013, France AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Neurophysiology, Paris 75013, France AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Neurology, Paris 75013, France.
authors: Lionel
authors: L
authors: Naccache
mesh_terms: D000161:Acoustic Stimulation; D000293:Adolescent; D000328:Adult; D001307:Auditory Perception / Q000502:physiology; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D004569:Electroencephalography; D004827:Epilepsy / Q000473:pathology*; D005071:Evoked Potentials / Q000502:physiology*; D005145:Face; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000503:physiopathology; D010775:Photic Stimulation; D013997:Time Factors; D014741:Video Recording; D055815:Young Adult
keywords: P300; connectivity; intracranial recordings; mismatch negativity; time-frequency