title: Photodynamic therapy for the treatment of microinvasive squamous cell carcinoma of the lower lip: a case report.
abstract: Photodynamic therapy (PDT) with methyl aminolevulinate (MAL) is approved in Europe for the treatment of actinic keratosis and Bowen's disease, both intraepithelial forms of squamous cell carcinoma (SCC). A therapeutic effect of MAL-PDT has been recently suggested for superficial, microinvasive and well-differentiated cutaneous SCC. We describe the successful use of MAL-PDT in a recently observed patient with microinvasive SCC of the lower lip and review published data on the use of PDT with MAL or d-aminolevulinic acid (ALA) in cutaneous microinvasive SCC. A patient with a biopsy-proven recurrent microinvasive SCC of the lower lip was treated with 2 cycles of MAL-PDT. Complete clinical, dermoscopic and histopathological clearance was obtained after 2 cycles of MAL-PDT with an excellent cosmetic result and a sustained remission after 24-month follow-up. A review of the few studies reporting on the use of MAL-PDT or ALA-PDT for cutaneous microinvasive SCCs was carried out. MAL-PDT might represent a non-invasive treatment option for microinvasive SCC of the lower lip if patients are not eligible for surgery. Post-treatment histopathological confirmation and a long-term follow-up are strictly recommended.
authors: Department of Dermatology, University of L'Aquila, L'Aquila, Italy - ketty.peris@univaq.it.
authors: M C
authors: MC
authors: Fargnoli
authors: D
authors: D
authors: Kostaki
authors: A
authors: A
authors: Piccioni
authors: A
authors: A
authors: Di Stefani
authors: K
authors: K
authors: Peris
mesh_terms: D000368:Aged; D000622:Aminolevulinic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D002613:Cheilitis / Q000188:drug therapy; D046169:Dermoscopy; D006801:Humans; D008048:Lip Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009361:Neoplasm Invasiveness; D009381:Neoplasms, Radiation-Induced / Q000188:drug therapy* / Q000473:pathology; D016609:Neoplasms, Second Primary / Q000188:drug therapy / Q000473:pathology; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D013472:Sunlight / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D017319:Photosensitizing Agents; C475457:methyl 5-aminolevulinate; D000622:Aminolevulinic Acid