title: Dual task walking reveals cognitive dysfunction in community-dwelling elderly subjects: the Sefuri brain MRI study.
abstract: The aim of our study was to investigate the effects of subclinical brain lesions and cognitive function on gait performance with or without concurrent cognitive task in community-dwelling elderly subjects. Participants without dementia (92 men and 109 women with a mean age of 67.8 years) underwent brain magnetic resonance imaging, neuropsychologic tests, and gait measurements. Impaired gait velocity of the Timed Up and Go test was associated with deep white matter lesions (odds ratio [OR], 2.338; 95% confidence interval [CI], 1.120-4.880) and diabetes mellitus (OR, 2.725; 95% CI, 1.120-6.630) after adjusted for age, sex, education, and cognitive function tests. Impaired gait velocity of dual task walking was associated with age and the score of Rivermead Behavioral Memory Test (OR, .899/1 point higher; 95% CI, .813-.994), whereas deep white matter lesions were not significantly associated with dual task walking. The present study showed that gait represents not only physical functioning but also subclinical cognitive dysfunction particularly memory impairment in healthy elderly subjects.
authors: Center for Emotional and Behavioral Disorders, National Hospital Organization Hizen Psychiatric Center, Saga, Japan.
authors: Manabu
authors: M
authors: Hashimoto
authors: Center for Emotional and Behavioral Disorders, National Hospital Organization Hizen Psychiatric Center, Saga, Japan.
authors: Yuki
authors: Y
authors: Takashima
authors: Department of Diagnostic Radiology, Saitama Medical University International Medical Center, Saitama, Japan.
authors: Akira
authors: A
authors: Uchino
authors: Center for Emotional and Behavioral Disorders, National Hospital Organization Hizen Psychiatric Center, Saga, Japan.
authors: Takefumi
authors: T
authors: Yuzuriha
authors: Center for Emotional and Behavioral Disorders, National Hospital Organization Hizen Psychiatric Center, Saga, Japan. Electronic address: hyao@hizen2.hosp.go.jp.
authors: Hiroshi
authors: H
authors: Yao
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology*; D059345:Cerebral Small Vessel Diseases / Q000473:pathology; D003072:Cognition Disorders / Q000473:pathology* / Q000523:psychology*; D005260:Female; D020233:Gait Disorders, Neurologic / Q000473:pathology / Q000523:psychology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012959:Socioeconomic Factors; D016138:Walking / Q000502:physiology*; D066127:White Matter / Q000473:pathology
keywords: Gait; cognition; magnetic resonance imaging; silent stroke; small vessel disease; white matter lesions