title: Cytotoxicity of Aporphine, Protoberberine, and Protopine Alkaloids from Dicranostigma leptopodum (Maxim.) Fedde.
abstract: Nine alkaloids with three different structural skeletons were isolated from Dicranostigma leptopodum (Maxim.) Fedde (Papaveraceae) by repeated silica gel column chromatography. Their chemical structures were identified on the basic of physicochemical and spectroscopic data. Among them, 10-O-methylhernovine (1), nantenine (2), corytuberine (3), lagesianine A (4), and dihydrocryptopine (9) were first isolated from this plant. With a series of cytotoxic tests, compounds 2, 3, and 7 displayed cytotoxicity against SMMC-7721 with IC50 values of 70.08 ± 4.63, 73.22 ± 2.35, and 27.77 ± 2.29 μ M, respectively.
authors: Analytic and Testing Center, Beijing Normal University, No. 19 Xinjiekouwai Street, Haidian District, Beijing 100875, China.
authors: Ruiqi
authors: 0000-0002-5433-2380
authors: R
authors: Sun
authors: College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, Liaoning 116600, China.
authors: Haiyan
authors: H
authors: Jiang
authors: State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Beijing 100875, China.
authors: Wenjuan
authors: W
authors: Zhang
authors: State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Beijing 100875, China.
authors: Kai
authors: K
authors: Yang
authors: Key Laboratory of Radiological Protection and Nuclear Emergency, Chinese Center for Disease Control and Prevention, Haidian District, Beijing 100875, China.
authors: Chengfang
authors: C
authors: Wang
authors: Key Laboratory of Radiological Protection and Nuclear Emergency, Chinese Center for Disease Control and Prevention, Haidian District, Beijing 100875, China.
authors: Li
authors: L
authors: Fan
authors: Analytic and Testing Center, Beijing Normal University, No. 19 Xinjiekouwai Street, Haidian District, Beijing 100875, China.
authors: Qing
authors: 0000-0003-2873-1297
authors: Q
authors: He
authors: Key Laboratory of Radiological Protection and Nuclear Emergency, Chinese Center for Disease Control and Prevention, Haidian District, Beijing 100875, China.
authors: Jiangbin
authors: J
authors: Feng
authors: State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Beijing 100875, China.
authors: Shushan
authors: S
authors: Du
authors: Analytic and Testing Center, Beijing Normal University, No. 19 Xinjiekouwai Street, Haidian District, Beijing 100875, China.
authors: Zhiwei
authors: Z
authors: Deng
authors: Analytic and Testing Center, Beijing Normal University, No. 19 Xinjiekouwai Street, Haidian District, Beijing 100875, China.
authors: Zhufeng
authors: Z
authors: Geng