title: Dopamine receptor heteromeric complexes and their emerging functions.
abstract: Dopamine neurotransmission is traditionally accepted as occurring through the five dopamine receptors that transduce its signal. Recent evidence has demonstrated that the range of physiologically relevant dopamine signaling complexes is greatly expanded by the ability of dopamine receptors to interact with other dopamine receptors and with receptors of other endogenous signaling ligands. These novel heteromeric complexes have functional properties distinct from the component receptors or are able to modulate the canonical signaling and function of the cognate receptors. These dopamine receptor heteromers provide new insight into physiological mechanisms and pathophysiological processes involving dopamine.
authors: Departments of Medicine and Pharmacology, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada. Electronic address: s.george@utoronto.ca.
authors: Susan R
authors: SR
authors: George
authors: Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL, USA.
authors: Andras
authors: A
authors: Kern
authors: Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL, USA.
authors: Roy G
authors: RG
authors: Smith
authors: Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Spain.
authors: Rafael
authors: R
authors: Franco
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D011954:Receptors, Dopamine / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D011954:Receptors, Dopamine; D004298:Dopamine
keywords: BRET; D1 receptor; D2 receptor; SRET; adenosine receptor; confocal FRET; dopamine receptor heteromer; ghrelin receptor; oligomerization