title: Spatial patterns of whole brain grey and white matter injury in patients with occult spastic diplegic cerebral palsy.
abstract: Spastic diplegic cerebral palsy (SDCP) is a common type of cerebral palsy (CP), which presents as a group of motor-impairment syndromes. Previous conventional MRI studies have reported abnormal structural changes in SDCP, such as periventricular leucomalacia. However, there are roughly 27.8% SDCP patients presenting normal appearance in conventional MRI, which were considered as occult SDCP. In this study, sixteen patients with occult SDCP and 16 age- and sex-matched healthy control subjects were collected and the data were acquired on a 3T MR system. We applied voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) analysis to investigate whole brain grey and white matter injury in occult SDCP. By using VBM method, the grey matter volume reduction was revealed in the bilateral basal ganglia regions, thalamus, insula, and left cerebral peduncle, whereas the white matter atrophy was found to be located in the posterior part of corpus callosum and right posterior corona radiata in the occult SDCP patients. By using TBSS, reduced fractional anisotropy (FA) values were detected in multiple white matter regions, including bilateral white matter tracts in prefrontal lobe, temporal lobe, internal and external capsule, corpus callosum, cingulum, thalamus, brainstem and cerebellum. Additionally, several regions of white matter tracts injury were found to be significantly correlated with motor dysfunction. These results collectively revealed the spatial patterns of whole brain grey and white matter injury in occult SDCP.
authors: Department of Radiology, Chinese PLA General Hospital, Beijing, China; Department of MRI, The General Hospital of Chinese People's Armed Police Forces, Beijing, China.
authors: Xuetao
authors: X
authors: Mu
authors: Key Laboratory of Nuclear Analysis Techniques, Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China.
authors: Binbin
authors: B
authors: Nie
authors: Department of MRI, The General Hospital of Chinese People's Armed Police Forces, Beijing, China.
authors: Hong
authors: H
authors: Wang
authors: Key Laboratory of Nuclear Analysis Techniques, Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China.
authors: Shaofeng
authors: S
authors: Duan
authors: Neurosurgical Institute, The General Hospital of Chinese People's Armed Police Forces, Beijing, China.
authors: Zan
authors: Z
authors: Zhang
authors: Neurosurgical Institute, The General Hospital of Chinese People's Armed Police Forces, Beijing, China.
authors: Guanghui
authors: G
authors: Dai
authors: Department of MRI, The General Hospital of Chinese People's Armed Police Forces, Beijing, China.
authors: Qiaozhi
authors: Q
authors: Ma
authors: Key Laboratory of Nuclear Analysis Techniques, Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China.
authors: Baoci
authors: B
authors: Shan
authors: Department of Radiology, Chinese PLA General Hospital, Beijing, China.
authors: Lin
authors: L
authors: Ma
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002547:Cerebral Palsy / Q000473:pathology* / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D066128:Gray Matter / Q000293:injuries* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009043:Motor Activity; D009929:Organ Size; D062206:Spatial Analysis; D066127:White Matter / Q000293:injuries* / Q000473:pathology / Q000503:physiopathology