title: Nitrogen-containing dihydro-β-agarofuran derivatives from Tripterygium wilfordii.
abstract: Thunder god vine, the dried roots of Tripterygium wilfordii, is a widely used traditional Chinese medicine. More than 200 bioactive complex natural products have been isolated from this herb. Inspired by the diversity of chemical structures and bioactivities of the components of this herb, the investigation to mine new chemical entities as potential drug leads led to the identification of 36 nitrogen-containing compounds. Among them, 18 new dihydro-β-agarofuran alkaloids (tripterygiumines A-L (1-12), M-Q (22-26), and R (33)) were identified from the spectroscopic data and chemical degradation studies. Tripterygiumine Q (26) exhibited immunosuppressive activity against human peripheral mononuclear cells with an IC50 value of 8.67 μM and showed no cytotoxicity, even at 100 μM, indicating that 26 may represent a novel scaffold for the development of new immunosuppressants.
authors: Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences , 9 Section 4, Renmin Road South, Chengdu 610041, People's Republic of China.
authors: Yinggang
authors: Y
authors: Luo
authors: Xiang
authors: X
authors: Pu
authors: Guoyong
authors: G
authors: Luo
authors: Min
authors: M
authors: Zhou
authors: Qi
authors: Q
authors: Ye
authors: Yan
authors: Y
authors: Liu
authors: Jian
authors: J
authors: Gu
authors: Huayi
authors: H
authors: Qi
authors: Guoyou
authors: G
authors: Li
authors: Guolin
authors: G
authors: Zhang
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D029757:Tripterygium / Q000737:chemistry
chemical_list: D000470:Alkaloids; D004365:Drugs, Chinese Herbal; D007166:Immunosuppressive Agents; C000591562:tripterygiumine Q; D009584:Nitrogen