title: [Biological network modelling and precision medicine in oncology].
abstract: Precision medicine in oncology is becoming reality thanks to the next-generation sequencing of tumours and the development of targeted inhibitors enabling tailored therapies. Many clinical trials base their strategy on the identification of mutations to deliver the targeted inhibitor that counteract supposedly the effect of a mutated gene. Recent results have shown that this gene-centered strategy can be successful, but can also fall short in stopping progression. This is due to the many compensation mechanisms, cross-talks and feedback loops that enable the tumoral cell to escape treatment. Taking into account the regulatory network is necessary to establish which inhibitor or combination of inhibitors would achieve the best therapeutic results. Mathematical modelling of biological networks, together with high-quality pathway databases collecting our knowledge of the molecular circuitry of normal and tumoral cells, hold the hopes of an enhanced future for precision medicine in oncology.
authors: Institut Curie, 26 rue d'Ulm, 75248 Paris, France, INSERM U900, 75248 Paris, France, Mines ParisTech, 77300 Fontainebleau, France.
authors: Laurence
authors: L
authors: Calzone
authors: Institut Curie, 26 rue d'Ulm, 75248 Paris, France, INSERM U900, 75248 Paris, France, Mines ParisTech, 77300 Fontainebleau, France.
authors: Inna
authors: I
authors: Kuperstein
authors: Institut Curie, 26 rue d'Ulm, 75248 Paris, France, INSERM U900, 75248 Paris, France, Mines ParisTech, 77300 Fontainebleau, France.
authors: David
authors: D
authors: Cohen
authors: Institut Curie, 26 rue d'Ulm, 75248 Paris, France, INSERM U900, 75248 Paris, France, Mines ParisTech, 77300 Fontainebleau, France, Ecole Normale Supérieure, IBENS, 46 rue d'Ulm, Paris, France, CNRS UMR8197, 75005 Paris, France, INSERM U1024, 75005 Paris, France, Present address : Clinical Operational Research Unit, University College London, London, UK.
authors: Luca
authors: L
authors: Grieco
authors: Institut Curie, 26 rue d'Ulm, 75248 Paris, France, INSERM U900, 75248 Paris, France, Mines ParisTech, 77300 Fontainebleau, France.
authors: Eric
authors: E
authors: Bonnet
authors: Institut Curie, 26 rue d'Ulm, 75248 Paris, France, INSERM U900, 75248 Paris, France, Mines ParisTech, 77300 Fontainebleau, France.
authors: Nicolas
authors: N
authors: Servant
authors: Institut Curie, 26 rue d'Ulm, 75248 Paris, France, INSERM U900, 75248 Paris, France, Mines ParisTech, 77300 Fontainebleau, France, CNRS UMR144, 75248 Paris, France.
authors: Philippe
authors: P
authors: Hupé
authors: Institut Curie, 26 rue d'Ulm, 75248 Paris, France, INSERM U900, 75248 Paris, France, Mines ParisTech, 77300 Fontainebleau, France.
authors: Andrei
authors: A
authors: Zinovyev
authors: Institut Curie, 26 rue d'Ulm, 75248 Paris, France, INSERM U900, 75248 Paris, France, Mines ParisTech, 77300 Fontainebleau, France.
authors: Emmanuel
authors: E
authors: Barillot
mesh_terms: D016208:Databases, Factual; D006801:Humans; D008495:Medical Oncology / Q000379:methods* / Q000639:trends; D008954:Models, Biological; D009369:Neoplasms / Q000235:genetics / Q000628:therapy*; D057285:Precision Medicine / Q000379:methods* / Q000639:trends
keywords: molecular profiles of tumour; network-based genomic analysis; pathway databases; systems biology; targeted inhibitor