title: Linezolid-induced lactic acidosis corrected with sustained low-efficiency dialysis: a case report.
abstract: Linezolid, an oxazolidinone antibiotic, has been reported to increase the risk of lactic acidosis and peripheral neuropathy because it disrupts mitochondrial function. This case report describes the development of lactic acidosis in a 63-year-old man who had received 3 months of treatment with intravenous linezolid for pulmonary nocardiasis, and correction of the acidotic state with sustained low-efficiency dialysis. This case demonstrates that renal replacement therapy can be an alternative to discontinuation alone for rapid reversal of linezolid-induced lactic acidosis.
authors: Huntsville Hospital, Huntsville, AL. Electronic address: adam.sawyer@hhsys.org.
authors: Adam J
authors: AJ
authors: Sawyer
authors: Huntsville Hospital, Huntsville, AL. Electronic address: haley0513@gmail.com.
authors: Heather L
authors: HL
authors: Haley
authors: Huntsville Hospital, Huntsville, AL.
authors: Sharon R
authors: SR
authors: Baty
authors: Huntsville Hospital, Huntsville, AL.
authors: Grant E
authors: GE
authors: McGuffey
authors: Huntsville Hospital, Huntsville, AL.
authors: Edward H
authors: EH
authors: Eiland
mesh_terms: D000081:Acetamides / Q000009:adverse effects*; D000140:Acidosis, Lactic / Q000139:chemically induced* / Q000628:therapy*; D000890:Anti-Infective Agents / Q000009:adverse effects*; D006801:Humans; D000069349:Linezolid; D008297:Male; D008875:Middle Aged; D023303:Oxazolidinones / Q000009:adverse effects*; D006435:Renal Dialysis / Q000379:methods*
chemical_list: D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D000069349:Linezolid
keywords: Linezolid; Zyvox; dialysis; lactic acidosis; oxazolidinone antibiotic; renal replacement therapy; sustained low-efficiency dialysis (SLED)