title: Pathway-based toxicity: history, current approaches and liver fibrosis and steatosis as prototypes.
abstract: The Human Toxicology Project Consortium (HTPC) was created to accelerate implementation of the science and policies required to achieve a pathway-based foundation for toxicology as articulated in the 2007 National Research Council report, Toxicity Testing in the 21st Century: a Vision and a Strategy. The HTPC held a workshop, "Building Shared Experience to Advance Practical Application of Pathway-Based Toxicology: Liver Toxicity Mode-of-Action," in January, 2013, in Baltimore, MD, to further the science of pathway-based approaches to liver toxicity. This review was initiated as a thought-starter for this workshop and has since been updated to include insights from the workshop and other activities occurring in 2013. The report of the workshop has been published elsewhere in this journal (Willett et al., 2014).
authors: The Humane Society of the United States, Gaithersburg, MD, USA.
authors: Catherine
authors: C
authors: Willett
authors: Jessica
authors: J
authors: Caverly Rae
authors: Katy O
authors: KO
authors: Goyak
authors: Brigitte
authors: B
authors: Landesmann
authors: Gary
authors: G
authors: Minsavage
authors: Carl
authors: C
authors: Westmoreland
mesh_terms: D000818:Animals; D005234:Fatty Liver / Q000139:chemically induced*; D015386:Hazardous Substances / Q000633:toxicity*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008103:Liver Cirrhosis / Q000139:chemically induced*; D011237:Predictive Value of Tests; D018675:Toxicity Tests / Q000266:history* / Q000639:trends*
chemical_list: D015386:Hazardous Substances