title: H3N2 canine influenza virus with the matrix gene from the pandemic A/H1N1 virus: infection dynamics in dogs and ferrets.
abstract: After an outbreak of pandemic influenza A/H1N1 (pH1N1) virus, we had previously reported the emergence of a recombinant canine influenza virus (CIV) between the pH1N1 virus and the classic H3N2 CIV. Our ongoing routine surveillance isolated another reassortant H3N2 CIV carrying the matrix gene of the pH1N1 virus from 2012. The infection dynamics of this H3N2 CIV variant (CIV/H3N2mv) were investigated in dogs and ferrets via experimental infection and transmission. The CIV/H3N2mv-infected dogs and ferrets produced typical symptoms of respiratory disease, virus shedding, seroconversion, and direct-contact transmissions. Although indirect exposure was not presented for ferrets, CIV/H3N2mv presented higher viral replication in MDCK cells and more efficient transmission was observed in ferrets compared to classic CIV H3N2. This study demonstrates the effect of reassortment of the M gene of pH1N1 in CIV H3N2.
authors: Research Unit,Green Cross Veterinary Products, Yongin, Gyeonggi,Republic of Korea.
authors: H
authors: H
authors: Moon
authors: Viral Infectious Disease Research Center,Korea Research Institute of Bioscience and Biotechnology,Daejeon,Republic of Korea.
authors: M
authors: M
authors: Hong
authors: College of Pharmacy,Korea University,Sejong,Republic of Korea.
authors: J K
authors: JK
authors: Kim
authors: Research Unit,Green Cross Veterinary Products, Yongin, Gyeonggi,Republic of Korea.
authors: B
authors: B
authors: Seon
authors: Viral Infectious Disease Research Center,Korea Research Institute of Bioscience and Biotechnology,Daejeon,Republic of Korea.
authors: W
authors: W
authors: Na
authors: Viral Infectious Disease Research Center,Korea Research Institute of Bioscience and Biotechnology,Daejeon,Republic of Korea.
authors: S J
authors: SJ
authors: Park
authors: Animal and Plant Quarantine Agency,Anyang, Gyeonggi,Republic of Korea.
authors: D J
authors: DJ
authors: An
authors: Animal and Plant Quarantine Agency,Anyang, Gyeonggi,Republic of Korea.
authors: H Y
authors: HY
authors: Jeoung
authors: Viral Infectious Disease Research Center,Korea Research Institute of Bioscience and Biotechnology,Daejeon,Republic of Korea.
authors: D J
authors: DJ
authors: Kim
authors: Research Unit,Green Cross Veterinary Products, Yongin, Gyeonggi,Republic of Korea.
authors: J M
authors: JM
authors: Kim
authors: Viral Infectious Disease Research Center,Korea Research Institute of Bioscience and Biotechnology,Daejeon,Republic of Korea.
authors: S H
authors: SH
authors: Kim
authors: St Jude Children's Research Hospital,Memphis, TN,USA.
authors: R J
authors: RJ
authors: Webby
authors: St Jude Children's Research Hospital,Memphis, TN,USA.
authors: R G
authors: RG
authors: Webster
authors: Research Unit,Green Cross Veterinary Products, Yongin, Gyeonggi,Republic of Korea.
authors: B K
authors: BK
authors: Kang
authors: Viral Infectious Disease Research Center,Korea Research Institute of Bioscience and Biotechnology,Daejeon,Republic of Korea.
authors: D
authors: D
authors: Song
mesh_terms: D000818:Animals; D001483:Base Sequence; D004283:Dog Diseases / Q000453:epidemiology / Q000635:transmission / Q000821:virology*; D004285:Dogs / Q000821:virology; D005289:Ferrets / Q000821:virology*; D005814:Genes, Viral / Q000235:genetics; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics*; D053122:Influenza A Virus, H3N2 Subtype / Q000235:genetics / Q000302:isolation & purification; D061985:Madin Darby Canine Kidney Cells / Q000821:virology; D008969:Molecular Sequence Data; D009976:Orthomyxoviridae Infections / Q000453:epidemiology / Q000235:genetics / Q000635:transmission / Q000662:veterinary*; D058873:Pandemics / Q000706:statistics & numerical data / Q000662:veterinary*; D011995:Recombination, Genetic / Q000235:genetics; D014763:Viral Matrix Proteins / Q000235:genetics
chemical_list: D014763:Viral Matrix Proteins
keywords: transmission