title: Nutraceuticals in joint health: animal models as instrumental tools.
abstract: Osteoarthritis (OA) is a degenerative joint disease with no curative treatments. Many studies have begun to demonstrate the efficacy of nutraceuticals for slowing down OA. Animal models are utilized as a compulsory step in demonstrating the protective potential of these compounds on joint health. Nevertheless, there exist a wide variety of available OA models and selecting a suitable system for evaluating the effects of a specific compound remains difficult. Here, we discuss animal studies that have investigated nutraceutical effects on OA. In particular, we highlight the large spectrum of animal models that are currently accepted for examining the OA-related effects of nutraceuticals, giving recommendations for their use.
authors: INSERM, UMR 791, Skeletal Tissue Engineering and Physiopathology team LIOAD, Nantes, France; Union Grap'Sud, Cruviers-Lascours, France; Université de Nantes, UFR Odontologie, Nantes, France.
authors: Elsa
authors: E
authors: Mével
authors: Université d'Auvergne, Unité de Nutrition Humaine, Clermont-Ferrand, France; INRA, UMR 1019, Unité de Nutrition Humaine, CRNH Auvergne, Clermont-Ferrand, France.
authors: Laurent-Emmanuel
authors: LE
authors: Monfoulet
authors: INSERM, UMR 791, Skeletal Tissue Engineering and Physiopathology team LIOAD, Nantes, France; Université de Nantes, UFR Odontologie, Nantes, France.
authors: Christophe
authors: C
authors: Merceron
authors: Université d'Auvergne, Unité de Nutrition Humaine, Clermont-Ferrand, France; INRA, UMR 1019, Unité de Nutrition Humaine, CRNH Auvergne, Clermont-Ferrand, France.
authors: Véronique
authors: V
authors: Coxam
authors: Université d'Auvergne, Unité de Nutrition Humaine, Clermont-Ferrand, France; INRA, UMR 1019, Unité de Nutrition Humaine, CRNH Auvergne, Clermont-Ferrand, France.
authors: Yohann
authors: Y
authors: Wittrant
authors: INSERM, UMR 791, Skeletal Tissue Engineering and Physiopathology team LIOAD, Nantes, France; Université de Nantes, UFR Odontologie, Nantes, France.
authors: Laurent
authors: L
authors: Beck
authors: INSERM, UMR 791, Skeletal Tissue Engineering and Physiopathology team LIOAD, Nantes, France; Université de Nantes, UFR Odontologie, Nantes, France; CHU Nantes, PHU 4 OTONN, Nantes, France. Electronic address: jerome.guicheux@inserm.fr.
authors: Jérôme
authors: J
authors: Guicheux
mesh_terms: D000818:Animals; D019587:Dietary Supplements; D007596:Joints; D023421:Models, Animal; D010003:Osteoarthritis / Q000178:diet therapy* / Q000188:drug therapy