title: Relationship between MCP-1 promoter -2518 A/G gene polymorphism (rs1024611) and systemic lupus erythematosus/lupus nephritis.
abstract: Results from the published studies on the association between monocyte chemoattractant protein-1 (MCP-1) promoter -2518 A/G (rs1024611) gene polymorphism and systemic lupus erythematosus (SLE)/lupus nephritis (LN) are still conflicting. This meta-analysis was performed to evaluate the relationship between MCP-1 A/G gene polymorphism and SLE/LN and to explore whether MCP-1 A allele, AA genotype or GG genotype could become a predictive marker for SLE/LN risk. Association studies were identified from the databases of PubMed, Embase, Cochrane Library and CBM-disc (China Biological Medicine Database) as of 1 January 2014, and eligible investigations were synthesized using meta-analysis method. Results were expressed with odds ratios (OR) for dichotomous data, and 95% confidence intervals (CI) were also calculated. Sixteen investigations were identified for the analysis of association between MCP-1 A/G gene polymorphism and SLE, consisting of 2425 patients with SLE and 2567 controls. In the overall populations, Asians, Caucasian population, the association between MCP-1 A/G gene polymorphism and SLE susceptibility was not found. Interestingly, a trend toward an association between A allele/AA genotype and LN risk was observed in overall populations, although there was no statistical difference. However, this meta-analysis indicated that AA genotype was associated with LN risk in Caucasians (OR = 0.71; 95% CI: 0.54-0.93; p = 0.01). In conclusion, our results indicate that AA homozygous might be a significant genetic molecular marker to predict the SLE patients developing into LN in Caucasians. However, more investigations are required to further clarify this association.
authors: Department of Nephrology, The Sixth Affiliated Hospital, Sun Yat-Sen University , Guangzhou , China.
authors: Tian-Biao
authors: TB
authors: Zhou
authors: Zong-Pei
authors: ZP
authors: Jiang
authors: Meng-Jun
authors: MJ
authors: Liang
authors: Ya-Juan
authors: YJ
authors: Huang
mesh_terms: D018932:Chemokine CCL2 / Q000235:genetics*; D002681:China; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000473:pathology; D008181:Lupus Nephritis / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D044465:White People
chemical_list: C111835:CCL2 protein, human; D018932:Chemokine CCL2
keywords: A/G gene polymorphism; lupus nephritis; meta-analysis; monocyte chemoattractant protein-1; systemic lupus erythematosus