title: Hemorheologic effects of dibornol in a model of myocardial ischemia/reperfusion.
abstract: We studied the effects of novel sterically hindered phenol, 4-methyl-2,6-diisobornyl phenol (dibornol) on the rheological properties of the blood in the model of myocardial ischemia/reperfusion. Dibornol (100 mg/kg intraperitoneally for 3 days before and 5 days after ischemia/reperfusion) decreased blood viscosity by 9-25% in comparison with that in sham-operatedanimals by modulating cellular (erythrocyte deformability and aggregation) and plasma (plasma viscosity) rheological parameters. Normalization of blood rheology under the influence of dibornol increased the availability of oxygen to tissues at high shear rates by 9-18% after acute ischemia/reperfusion in rats.
authors: Department of Pharmacology, Siberian State Medical University, Tomsk, Russia.
authors: T M
authors: TM
authors: Plotnikova
authors: G A
authors: GA
authors: Chernysheva
authors: V I
authors: VI
authors: Smol'yakova
authors: P P
authors: PP
authors: Shchetinin
authors: A V
authors: AV
authors: Kuchin
authors: I Yu
authors: IY
authors: Chukicheva
authors: M B
authors: MB
authors: Plotnikov
mesh_terms: D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects; D001892:Camphanes / Q000494:pharmacology* / Q000627:therapeutic use*; D003408:Cresols / Q000494:pharmacology* / Q000627:therapeutic use*; D004907:Erythrocyte Deformability / Q000187:drug effects; D008297:Male; D017202:Myocardial Ischemia / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar
chemical_list: C533990:4-methyl-2,6-diisobornylphenol; D001892:Camphanes; D003408:Cresols