title: Predictive factors for red blood cell transfusion in children undergoing noncomplex cardiac surgery.
abstract: BACKGROUND
  Red blood cell (RBC) transfusion is frequently required in pediatric cardiac surgery and is associated with altered outcome and increased costs. Determining which factors predict transfusion in this context will enable clinicians to adopt strategies that will reduce the risk of RBC transfusion. This study aimed to assess predictive factors associated with RBC transfusion in children undergoing low-risk cardiac surgery with cardiopulmonary bypass (CPB).
  
  
  METHODS
  Children undergoing surgery to repair ventricular septal defect or atrioventricular septal defect from 2006 to 2011 were included in this retrospective study. Demography, preoperative laboratory testing, intraoperative data, and RBC transfusion were reviewed. Univariate and multivariate logistic regression analysis were used to define factors that were able to predict RBC transfusion. Then, we employed receiver operating characteristic analysis to design a predictive score.
  
  
  RESULTS
  Among the 334 children included, 261 (78%) were transfused. Age (<18 months), priming volume of the CPB (>43 mL/kg), type of oxygenator used, minimal temperature reached during CPB (<32°C), and preoperative hematocrit (<34%) were independently associated with RBC transfusion in the studied population. A predictive score 2 or greater was the best predictor of RBC transfusion.
  
  
  CONCLUSIONS
  The present study identified several factors that were significantly associated with perioperative RBC transfusion. Based on these factors, we designed a predictive score that can be used to develop a patient-based blood management program with the aim of reducing the incidence of RBC transfusion.
authors: Department of Anesthesiology, Centre Hospitalier Universitaire Brugmann and Queen Fabiola Children's University Hospital, Brussels, Belgium.
authors: Muj
authors: M
authors: Mulaj
authors: Department of Anesthesiology, Centre Hospitalier Universitaire Brugmann and Queen Fabiola Children's University Hospital, Brussels, Belgium. Electronic address: davidfaraoni@icloud.com.
authors: David
authors: D
authors: Faraoni
authors: Pediatric Intensive Care Unit, Queen Fabiola Children's University Hospital, Brussels, Belgium.
authors: Ariane
authors: A
authors: Willems
authors: Department of Anesthesiology, Centre Hospitalier Universitaire Brugmann and Queen Fabiola Children's University Hospital, Brussels, Belgium.
authors: Cristel
authors: C
authors: Sanchez Torres
authors: Department of Anesthesiology, Centre Hospitalier Universitaire Brugmann and Queen Fabiola Children's University Hospital, Brussels, Belgium.
authors: Philippe
authors: P
authors: Van der Linden
mesh_terms: D006348:Cardiac Surgical Procedures; D002675:Child, Preschool; D017707:Erythrocyte Transfusion / Q000706:statistics & numerical data*; D005260:Female; D005544:Forecasting; D006343:Heart Septal Defects / Q000601:surgery; D006801:Humans; D007223:Infant; D008297:Male; D012189:Retrospective Studies