title: Stereoselective synthesis of triarylethylenes via copper-palladium catalyzed decarboxylative cross-coupling: synthesis of (Z)-tamoxifen.
abstract: The first Cu/Pd-catalyzed decarboxylative cross-coupling of 3,3-diarylacrylic acids with aryl bromides is described. Triarylethylenes were obtained in high yields with excellent stereoselectivities. This methodology was successfully applied to the stereoselective synthesis of (Z)-tamoxifen.
authors: Institut de Recherche de Chimie Paris, CNRS - Chimie ParisTech, 11 rue Pierre et Marie Curie, 75005 Paris, France. gerard.cahiez@chimie-paristech.fr.
authors: Gérard
authors: G
authors: Cahiez
authors: Alban
authors: A
authors: Moyeux
authors: Maël
authors: M
authors: Poizat
mesh_terms: D000179:Acrylates / Q000737:chemistry; D001965:Bromides / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D005030:Ethylenes / Q000138:chemical synthesis*; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D013629:Tamoxifen / Q000138:chemical synthesis*
chemical_list: D000179:Acrylates; D001965:Bromides; D005030:Ethylenes; D013629:Tamoxifen; D010165:Palladium; D003300:Copper; C036658:acrylic acid