title: A computational microscope focused on the sense of smell.
abstract: In this article, we review studies of the protagonists of the perception of smell focusing on Odorant-Binding Proteins and Olfactory Receptors. We notably put forward studies performed by means of molecular modeling, generally combined with experimental data. Those works clearly emphasize that computational approaches are now a force to reckon with. In the future, they will certainly be more and more used, notably in the framework of a computational microscope meant to observe how the laws of physics govern the biomolecular systems originating our sense of smell.
authors: Université de Nice - Sophia Antipolis, Institut de Chimie de Nice UMR 7272, Parc Valrose, 28 Avenue Valrose, 06108 Nice Cedex 2, France.
authors: Claire A
authors: CA
authors: de March
authors: Université de Nice - Sophia Antipolis, Institut de Chimie de Nice UMR 7272, Parc Valrose, 28 Avenue Valrose, 06108 Nice Cedex 2, France. Electronic address: jerome.golebiowski@unice.fr.
authors: Jérôme
authors: J
authors: Golebiowski
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D018034:Olfactory Receptor Neurons / Q000378:metabolism*; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D018035:Receptors, Odorant / Q000737:chemistry* / Q000378:metabolism*; D012903:Smell
chemical_list: D018035:Receptors, Odorant; C045648:odorant-binding protein
keywords: Molecular modeling; Odorant-Binding Protein; Olfactory receptor; Structure–function