title: Analysis of factors associated with portal vein thrombosis in pediatric living donor liver transplant recipients.
abstract: The technique of vascular reconstruction plays a major role in the outcome of living donor liver transplantation (LDLT). An increased use of vascular grafts (VGs) as replacements for sclerotic portal veins has become a standard technique for our group. The aim of this study was to analyze the factors associated with portal vein thrombosis (PVT) in pediatric LDLT. We performed a retrospective analysis of 486 primary pediatric LDLT procedures performed between October 1995 and May 2013. VGs used for portal reconstruction included living donor inferior mesenteric veins, living donor ovarian veins, recipient internal jugular veins, deceased donor iliac arteries, and deceased donor iliac veins. Thirty-four patients (7.0%) developed PVT. The incidence of PVT dropped from 10.1% to 2%; the overall utilization of VGs increased from 3.5% to 37.1%. In a multivariate analysis, only the use of VGs remained an independent risk factor for the occurrence of PVT (hazard ratio = 7.2, 95% confidence interval = 2.8-18.7, P < 0.001). There was no difference in survival rates between patients with PVT and patients without PVT. No patient with PVT underwent retransplantation. In conclusion, the use of VGs was independently associated with the development of PVT. Over time, there was a reduction in the incidence of early PVT in this cohort, and there was a trend toward a reduction in total PVT. The occurrence of isolated PVT in this study was not associated with decreased patient or graft survival.
authors: Hepatology and Liver Transplantation, Hospital Sirio-Libanes, São Paulo, Brazil; A. C. Camargo Cancer Center, São Paulo, Brazil.
authors: Joao Seda
authors: JS
authors: Neto
authors: Eduardo A
authors: EA
authors: Fonseca
authors: Flávia H
authors: FH
authors: Feier
authors: Renata
authors: R
authors: Pugliese
authors: Helry L
authors: HL
authors: Candido
authors: Marcel R
authors: MR
authors: Benavides
authors: Gilda
authors: G
authors: Porta
authors: Irene K
authors: IK
authors: Miura
authors: Vera B
authors: VB
authors: Danesi
authors: Teresa
authors: T
authors: Guimaraes
authors: Adriana
authors: A
authors: Porta
authors: Cristian
authors: C
authors: Borges
authors: Andre
authors: A
authors: Godoy
authors: Mario
authors: M
authors: Kondo
authors: Paulo
authors: P
authors: Chapchap
mesh_terms: D001938:Brazil / Q000453:epidemiology; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007223:Infant; D016031:Liver Transplantation / Q000009:adverse effects* / Q000379:methods; D019520:Living Donors; D008297:Male; D011169:Portal Vein; D011183:Postoperative Complications; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate / Q000639:trends; D066027:Transplant Recipients; D020246:Venous Thrombosis / Q000453:epidemiology / Q000209:etiology*