title: Associations between vitamin D-binding protein (DBP) gene polymorphism (TAAA)n and development of osteoporosis in the Volga-Ural region of Russia.
abstract: Study of DBP gene (TAAA) n polymorphism in women of postmenopausal age revealed a significantly lower incidence of DBP(*) 10 allele and a higher incidence of DBP(*) 11 allele in Russian women with bone fractures in comparison with the relevant controls (χ(2) = 4.47, p = 0.034 and χ(2) = 4.28, p = 0.038, respectively). Allele DBP(*) 11 is a high risk marker (OR = 1.93; 95%CI 1.06-3.48), while allele DBP(*)10 a marker of low risk of bone fractures (OR = 0.59; 95%CI 0.37-0.94). A trend to a reduction of mineral density of the femoral neck and of the lumbar vertebrae in women with DBP(*) 10(*) 8 genotype of DBP gene polymorphic locus (TAAA) n in comparison with DBP(*) 10(*) 10 and DBP(*) 10(*) 11 genotype carriers is traced.
authors: Institute of Biochemistry and Genetics, Ural Research Center, the Russian Academy of Sciences, Ufa, Russia, ritakh@mail.ru.
authors: R I
authors: RI
authors: Khusainova
authors: L I
authors: LI
authors: Seleznyova
authors: A V
authors: AV
authors: Mal'tsev
authors: R Ya
authors: RY
authors: Shakirova
authors: R Z
authors: RZ
authors: Nurlygayanov
authors: D D
authors: DD
authors: Nadyrshina
authors: E K
authors: EK
authors: Khusnutdinova
mesh_terms: D000368:Aged; D005260:Female; D050723:Fractures, Bone / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D008875:Middle Aged; D010024:Osteoporosis / Q000453:epidemiology* / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics; D012426:Russia; D014809:Vitamin D-Binding Protein / Q000235:genetics*
chemical_list: D014809:Vitamin D-Binding Protein