title: Value of the atopy patch test in the diagnosis of food allergy in children with gastrointestinal symptoms.
abstract: BACKGROUND
  In recent years, food allergy, especially in the child population, has become an increasing problem in developed societies. In the youngest children, it is a frequent cause of gastrointestinal disorders. The atopy patch test, applied from several years in clinical practice, is one of the methods used in allergology.
  
  
  OBJECTIVE
  The objective of the work was an assessment of the diagnostic value of the atopy patch test in the diagnosis of allergy to cow's milk protein and to wheat proteins in children with gastrointestinal symptoms.
  
  
  METHODS
  The study was comprised of 61 children (37 boys and 24 girls, aged 3 to 36 months, average age 13.5 months). Their medical history might have indicated a connection between the symptoms and ingested food. In all the children, an atopy patch test and a skin prick test with native food allergens were carried out. Table 1 presents the characteristics of the studied patients. Diagnosis of allergy to cow's milk protein and to wheat was verified in the open food challenge.
  
  
  RESULTS
  Sensitivity of APT for milk was 21%, specificity - 91%, PPV - 80%, NPV - 39% and for wheat - 67%, 100%, 100% and 77%, respectively (Table 4). For the skin prick test, sensitivity, specificity, PPV and NPV were 13%, 96%, 83% and 39% for milk and 22%, 80%, 50% and 53% for wheat.
  
  
  CONCLUSIONS
  APT demonstrates high sensitivity and high specificity in the diagnosis of allergy to wheat in children with gastrointestinal symptoms. The sensitivity of ATP in the detection of allergy to cow's milk in children with gastrointestinal symptoms was low and therefore the diagnosis should be verified by challenge tests.
authors: Department of Pediatrics, Gastroenterology and Nutrition, Wroclaw Medical University, Poland.
authors: Krystyna
authors: K
authors: Mowszet
authors: Department of Pediatrics, Gastroenterology and Nutrition, Wroclaw Medical University, Poland.
authors: Krzysztof
authors: K
authors: Matusiewicz
authors: Department of Pediatrics, Gastroenterology and Nutrition, Wroclaw Medical University, Poland.
authors: Barbara
authors: B
authors: Iwańczak
mesh_terms: D000367:Age Factors; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000276:immunology*; D005260:Female; D005767:Gastrointestinal Diseases / Q000276:immunology*; D006801:Humans; D007223:Infant; D008297:Male; D016269:Milk Hypersensitivity / Q000175:diagnosis* / Q000276:immunology; D010328:Patch Tests; D011237:Predictive Value of Tests; D021182:Wheat Hypersensitivity / Q000175:diagnosis* / Q000276:immunology