title: Extracellular Ser/Thr/Tyr phosphorylated proteins of Pseudomonas aeruginosa PA14 strain.
abstract: Protein phosphorylation on serine, threonine, and tyrosine is known to be involved in a wide variety of cellular processes, signal transduction, and bacterial virulence. We characterized, for the first time, the extracellular phosphoproteins of the Pseudomonas aeruginosa PA14 strain. We identified 28 phosphoproteins (59 phosphosites) including enzymes, with various phosphorylation sites, known as potent secreted virulence factors in P. aeruginosa. The high phosphorylation level of these virulence factors might reflect a relationship between Ser/Thr/Tyr phosphorylation and virulence.
authors: Polymers, Biopolymers, Surfaces Laboratory, CNRS, UMR 6270, Mont-Saint-Aignan, France; Normandie University, UR, Mont-Saint-Aignan, France; PISSARO Proteomic Platform, Institute for Research and Innovation in Biomedicine, University of Rouen, Mont Saint Aignan, France.
authors: Tassadit
authors: T
authors: Ouidir
authors: Frédérique
authors: F
authors: Jarnier
authors: Pascal
authors: P
authors: Cosette
authors: Thierry
authors: T
authors: Jouenne
authors: Julie
authors: J
authors: Hardouin
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry* / Q000378:metabolism; D001426:Bacterial Proteins / Q000737:chemistry* / Q000378:metabolism; D005110:Extracellular Space / Q000737:chemistry / Q000378:metabolism; D013058:Mass Spectrometry; D008565:Membrane Proteins / Q000737:chemistry* / Q000378:metabolism; D008969:Molecular Sequence Data; D010750:Phosphoproteins / Q000737:chemistry* / Q000378:metabolism; D010766:Phosphorylation; D011550:Pseudomonas aeruginosa / Q000378:metabolism*
chemical_list: D000596:Amino Acids; D001426:Bacterial Proteins; D008565:Membrane Proteins; D010750:Phosphoproteins
keywords: Bacteria; Extracellular phosphoproteins; Mass spectrometry; Microbiology; Phosphorylation