title: [Economic cost of Streptococcus pneumoniae community-acquired pneumonia, meningitis and bacteremia in an adult population that required hospitalization in Bogotá, Colombia].
abstract: BACKGROUND
  Streptococcus pneumoniae infection in adults is related to pneumonia, meningitis and bacteremia. Its care costs in adults are not well documented in Colombia and it has a greater impact in people over 45 years old.
  
  
  OBJECTIVE
  The aims of this study were to analyze the associated costs of pneumonia, bacteremia and meningitis in invasive S. pneumoniae infection in Colombia among hospitalized adults and to estimate outpatient costs for community-acquired pneumonia. Additionally, we wanted to serve as a starting point for future economic evaluations.
  
  
  METHODS
  We performed a direct cost study associated with S. pneumoniae outpatient community-acquired pneumonia, bacteremia and meningitis costs confirmed by cultures. A cohort of hospitalized adults treated between January 2010 and June 2011 in three third level hospitals in Bogotá was analyzed. We evaluated 107 records and 60 bills charged to the payer. The data were classified according to care and treatment costs. We performed an estimate of direct costs for community-acquired pneumonia for outpatient cases through Delphi methodology using expert clinicians.
  
  
  RESULTS
  The average direct costs associated with pneumococcal disease were US$ 6,283, US$ 3,886, and US$ 4,768 for pneumonia, meningitis and bacteremia, respectively (exchange rate 1 US$ = Col$ 1,938.34; average variation between 2010 and 2011). Pneumonia cases were 70% men and 30% women; the distribution for meningitis was the same for both genders (50%); and for bacteremia we had 67% men and 33% women. Outpatient cost of community-acquired pneumonia was estimated at US$ 82.2 ( Col $ 159,280 ) in adults. For special cases, direct cost increased to US$ 142 ( Col $ 274,427).
  
  
  CONCLUSIONS
  The management of S. pneumoniae infection in people over 45 years old represents a high cost due to the use of drugs and hospitalization, which has a direct impact on health resources. Prevention and early treatment for pneumonia can reduce the cost and the burden of the disease.
authors: Investigadora independiente, Bogotá, D.C, Colombia.
authors: Claudia
authors: C
authors: Calderón
authors: Departamento de Investigaciones, Fundación Cardioinfantil-Instituto de Cardiología, Bogotá, D.C, Colombia.
authors: Rodolfo
authors: R
authors: Dennis
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000191:economics* / Q000628:therapy*; D003105:Colombia; D017714:Community-Acquired Infections / Q000191:economics / Q000628:therapy; D017281:Cost of Illness; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D008586:Meningitis, Pneumococcal / Q000191:economics* / Q000628:therapy*; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000191:economics* / Q000628:therapy*; D011018:Pneumonia, Pneumococcal / Q000191:economics* / Q000628:therapy*; D013296:Streptococcus pneumoniae; D055815:Young Adult