title: Incidence of leukocytoclastic vasculitis, 1996 to 2010: a population-based study in Olmsted County, Minnesota.
abstract: OBJECTIVE
  To determine the population-based incidence of leukocytoclastic vasculitis (LCV).
  
  
  METHODS
  This is a retrospective population-based study of all Olmsted County, Minnesota, residents with a skin biopsy-proven diagnosis of LCV from January 1, 1996, through December 31, 2010.
  
  
  RESULTS
  A total of 84 patients (mean age at diagnosis, 48.3 years) with newly diagnosed skin biopsy-proven LCV (43 women and 41 men) were identified. The incidence rate (age and sex adjusted to the 2000 US white population) was 4.5 per 100,000 person-years (95% CI, 3.5-5.4). The incidence of LCV increased significantly with age at diagnosis (P<.001) and did not differ between female and male patients. Subtypes of LCV were cutaneous small-vessel vasculitis (CSVV), 38 patients (45%); IgA vasculitis, 25 (30%); urticarial vasculitis, 10 (12%); cryoglobulinemic vasculitis, 3 (4%); and antineutrophil cytoplasmic antibody-associated vasculitis, 8 (10%). LCV was idiopathic in 29 of 38 patients with CSVV (76%) and 24 of 25 patients with IgA vasculitis (96%). Thirty-nine of 84 patients (46%) had systemic involvement, with the renal system most commonly involved (17 of 39 [44%]). Twenty-four of 80 patients (30%) with follow-up data available had recurrent disease. Compared with the Minnesota white population, observed survival in the incident LCV cohort was significantly poorer than expected (P<.001), including the subset of patients with idiopathic CSVV (P=.03).
  
  
  CONCLUSIONS
  The incidence of LCV was higher than that reported in previously published studies. Idiopathic LCV was more common in our population-based cohort than that described previously. Overall survival was significantly poorer (P<.001) and should be explored further in future studies.
authors: Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC.
authors: Amrita
authors: A
authors: Arora
authors: Department of Dermatology, Mayo Clinic, Rochester, MN. Electronic address: wetter.david@mayo.edu.
authors: David A
authors: DA
authors: Wetter
authors: Department of Dermatology, Mayo Clinic, Rochester, MN.
authors: Tania M
authors: TM
authors: Gonzalez-Santiago
authors: Department of Dermatology, Mayo Clinic, Rochester, MN.
authors: Mark D P
authors: MD
authors: Davis
authors: Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN.
authors: Christine M
authors: CM
authors: Lohse
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D016208:Databases, Factual; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008499:Medical Records / Q000706:statistics & numerical data; D008875:Middle Aged; D008910:Minnesota / Q000453:epidemiology; D011159:Population Surveillance / Q000379:methods*; D012189:Retrospective Studies; D017678:Sex Distribution; D012867:Skin / Q000473:pathology*; D015996:Survival Rate; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology; D055815:Young Adult