title: Matrine induces the apoptosis of lung cancer cells through downregulation of inhibitor of apoptosis proteins and the Akt signaling pathway.
abstract: Lung cancer is the leading cause of cancer‑related mortality in humans. The prognosis for advanced lung cancer patients is extremely poor. Current standard care is rather ineffective for prolonging patient life while preserving satisfactory quality of life due to adverse side-effects. Matrine extracted from the traditional Chinese herbal plant Sophora flavescens was shown to induce cancer cell death in vitro. The aim of this study was to investigate the effect of matrine on the proliferation and apoptosis of lung cancer cells and the molecular basis of matrine-induced apoptosis. The results showed that matrine inhibited cell proliferation and induced apoptosis in lung cancer A549 and 95D cells in a dose- and time-dependent manner. The apoptotic effects of matrine on lung cancer cells appeared to act via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K-Akt-mTOR) signaling pathway and downregulation of the expression of the inhibitor of apoptosis protein (IAP) family proteins. Matrine exerts its cancer-killing effect via promoting apoptosis in lung cancer cells and may be a useful adjuvant therapeutic scheme for treating advanced lung cancer patients.
authors: Department of Geriatrics, Shengjing Hospital, China Medical University, Shenyang 110004, P.R. China.
authors: Huiyan
authors: H
authors: Niu
authors: Department of Geriatrics, Shengjing Hospital, China Medical University, Shenyang 110004, P.R. China.
authors: Yifei
authors: Y
authors: Zhang
authors: Department of Geriatrics, Shengjing Hospital, China Medical University, Shenyang 110004, P.R. China.
authors: Baogang
authors: B
authors: Wu
authors: Department of Geriatrics, Shengjing Hospital, China Medical University, Shenyang 110004, P.R. China.
authors: Yi
authors: Y
authors: Zhang
authors: Department of Geriatrics, Shengjing Hospital, China Medical University, Shenyang 110004, P.R. China.
authors: Hongfang
authors: H
authors: Jiang
authors: Department of Geriatrics, Shengjing Hospital, China Medical University, Shenyang 110004, P.R. China.
authors: Ping
authors: P
authors: He
mesh_terms: D000470:Alkaloids / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D015536:Down-Regulation; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D011807:Quinolizines / Q000494:pharmacology*; D015398:Signal Transduction / Q000187:drug effects*; D000093842:Matrines
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D011807:Quinolizines; D051057:Proto-Oncogene Proteins c-akt; D000093842:Matrines