title: [Bone metabolism and cardiovascular function update. Lifestyle-related common diseases and osteoporosis].
abstract: In lifestyle-related common diseases, Diabetes mellitus is known to cause not only atherosclerosis and cardiovascular events but also bone fragility and high fracture risk. Advanced glycation endproducts (AGEs), which are deeply involved in diabetes pathogenesis, experimentally induce the calcification of aortic smooth muscle, while suppressing the osteoblastic differentiation and calcification of marrow stromal cells. AGEs also clinically and adversely affect fracture risk in diabetic patients. In contrast, bone deterioration is positively linked to the aggravation of lifestyle-related common diseases by diminishing in osteoblast-specific osteoclacin and Wnt signal, which increases blood glucose and triglyceride levels, and aggravates atherosclerosis.
authors: Internal Medicine 1, Shimane University Faculty of Medicine, Japan.
authors: Toru
authors: T
authors: Yamaguchi
mesh_terms: D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000150:complications / Q000378:metabolism*; D006801:Humans; D008019:Life Style; D010024:Osteoporosis / Q000150:complications / Q000378:metabolism*; D015398:Signal Transduction