title: [Association of CYP1A1 Ile462Val polymorphisms with susceptibility to small cell lung cancer].
abstract: OBJECTIVE
  To investigate the association of Ile462Val polymorphisms of cytochrome P450 1A1 (CYP1A1) gene with small cell lung cancer susceptibility.
  
  
  METHODS
  A case-control study was done in 275 patients with small cell lung cancer and 406 control subjects. Genotypes of CYP1A1 Ile462Val were determined by polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP). Logistic regression analysis was performed to estimate odd ratios (ORs) and 95% confidence intervals (95% CI) associated with genetic variants of CYP1A1.
  
  
  RESULTS
  A case-control analysis showed ORs of 0.65 (95% CI 0.48 - 0.91) and 0.60 (95% CI 0.32 - 0.97) for small cell lung cancer in the CYP1A1 462 Ile/Val and 462 Val/Val genotype carriers respectively, compared with 462 Ile/Ile carriers. When stratified by smoking status, the ORs of 462 Ile/Val or Val/Val genotype for nonsmokers and smokers were 0.99 (95% CI 0.62 - 1.51) and 0.42 (95% CI 0.26 - 0.65), respectively. Furthermore, for light and heavy smokers, the ORs of 462 Ile/ Val or Val/Val genotype were 0.42 (95% CI 0.21 - 0.85) and 0.44 (95% CI 0.24 - 0.82), respectively.
  
  
  CONCLUSIONS
  CYP1A1 Ile462Val polymorphisms may contribute to the decreased susceptibility of small cell lung cancer.
authors: Bing
authors: B
authors: He
authors: Jia
authors: J
authors: Lin
authors: Lei
authors: L
authors: Cao
authors: Hongge
authors: H
authors: Wang
authors: Juan
authors: J
authors: Rao
authors: Yingwen
authors: Y
authors: Liu
authors: Zhi
authors: Z
authors: Zhang
mesh_terms: D016022:Case-Control Studies; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D004198:Disease Susceptibility; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D055752:Small Cell Lung Carcinoma / Q000235:genetics*
chemical_list: D019363:Cytochrome P-450 CYP1A1