title: Fishing for targets: novel approaches using small molecule baits.
abstract: New technologies for target identification have emerged in the past few years. Driven by the development of novel proteomic tools and advances in analytical techniques, three new approaches have been successfully applied to drug discovery efforts by determining targets and off-targets. Recent progress in labeling live cells with activity-based probes will further aide a deeper understanding of the interaction of small molecules with a complex biological system on a molecular level.:
authors: ActivX Biosciences, 11025 N. Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address:katrins@activx.com.
authors: Katrin
authors: K
authors: Szardenings
authors: ActivX Biosciences, 11025 N. Torrey Pines Road, La Jolla, CA 92037, USA.
authors: Bei
authors: B
authors: Li
authors: ActivX Biosciences, 11025 N. Torrey Pines Road, La Jolla, CA 92037, USA.
authors: Lifu
authors: L
authors: Ma
authors: ActivX Biosciences, 11025 N. Torrey Pines Road, La Jolla, CA 92037, USA.
authors: Min
authors: M
authors: Wu