title: From meiogynin A to the synthesis of dual inhibitors of Bcl-xL and Mcl-1 anti-apoptotic proteins.
abstract: The synthesis of one of the most potent dual inhibitors of the anti-apoptotic proteins Bcl-xL and Mcl-1 is reported. This analogue of a natural sesquiterpenoid dimer meiogynin A was elaborated by a convergent asymmetric synthesis with 36% yield in ten steps.
authors: Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles (ICSN), CNRS UPR 2301, 1 av de la Terrasse, 91 198 Gif-sur-Yvette Cedex, France. fanny.roussi@cnrs.fr.
authors: S
authors: S
authors: Desrat
authors: C
authors: C
authors: Remeur
authors: C
authors: C
authors: Gény
authors: G
authors: G
authors: Rivière
authors: C
authors: C
authors: Colas
authors: V
authors: V
authors: Dumontet
authors: N
authors: N
authors: Birlirakis
authors: B I
authors: BI
authors: Iorga
authors: F
authors: F
authors: Roussi
mesh_terms: D061565:Cycloaddition Reaction / Q000379:methods*; D008958:Models, Molecular; D062105:Molecular Docking Simulation; D064549:Myeloid Cell Leukemia Sequence 1 Protein / Q000037:antagonists & inhibitors / Q000378:metabolism*; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000494:pharmacology; D051020:bcl-X Protein / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: C579095:MCL1 protein, human; D064549:Myeloid Cell Leukemia Sequence 1 Protein; D012717:Sesquiterpenes; D051020:bcl-X Protein; C548770:meiogynin A