title: Levels of 1,25(OH)2D3 for patients with pulmonary tuberculosis and correlations of 1,25(OH)2D3 with the clinical features of TB.
abstract: BACKGROUND
  To determine the 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] concentrations to patients with tuberculosis (TB) and whether it influenced the patient's clinical features.
  
  
  METHODS
  For the first part, a total of 153 healthy adults and 74 patients with pulmonary TB (PTB) were enrolled. Serum concentrations of 1,25(OH)2D3 were determined by liquid chromatography-tandem mass spectroscopy to examine the 1,25(OH)2D3 concentrations of the two groups from the peripheral blood. If there are differences between the two groups, what follow will increase the experimental group numbers to examine the relationship among the 1,25(OH)2D3 concentrations with the numbers of the lesion area, the tubercule bacilli in sputum and the CD4/CD8 ratio of T lymphocytes in the peripheral blood.
  
  
  RESULTS
  In the first part, the 1,25(OH)2D3 concentrations was lower in patients with TB than in those healthy adults [365.9 (SD 235.7) vs. 464.3 (SD 335.6), P<0.05]. In the second part, we increased the sample size to 134 (male 91 cases, female 43 cases). we found that the plasma levels of 1,25(OH)2D3 are not correlated with the numbers of the lesion area and the tubercule bacilli in sputum, but the 1,25(OH)2D3 levels can interact the ratio of CD4/CD8 T lymphocytes, it shows a positive correlation with the ratio of CD4/CD8 T lymphocytes.
  
  
  CONCLUSIONS
  The 1,25(OH)2D3 concentrations in TB patients lower than the healthy adults, it might exist as a risk factor during the development of TB or TB might affect the levels of 1,25(OH)2D3. But the different status vitamin D concentration might not affect the numbers of the lesion area, the tubercule bacilli in sputum. It shows a positive correlation with the ratio of CD4/CD8 T lymphocytes. The study will have a significance value to clinical medicine, but further study will need to study the levels of 1,25(OH)2D3 with the TB.
authors: 1 Department of Tuberculosis, Nanjing Chest Hospital, Nanjing 210029, China ; 2 Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing 210093, China ; 3 Department of Respiratory Medicine, Nanjing Children's Hospital Affiliated with Nanjing Medical University, Nanjing 210008, China.
authors: Wei-Wei
authors: WW
authors: Gao
authors: 1 Department of Tuberculosis, Nanjing Chest Hospital, Nanjing 210029, China ; 2 Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing 210093, China ; 3 Department of Respiratory Medicine, Nanjing Children's Hospital Affiliated with Nanjing Medical University, Nanjing 210008, China.
authors: Yu
authors: Y
authors: Wang
authors: 1 Department of Tuberculosis, Nanjing Chest Hospital, Nanjing 210029, China ; 2 Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing 210093, China ; 3 Department of Respiratory Medicine, Nanjing Children's Hospital Affiliated with Nanjing Medical University, Nanjing 210008, China.
authors: Xiang-Rong
authors: XR
authors: Zhang
authors: 1 Department of Tuberculosis, Nanjing Chest Hospital, Nanjing 210029, China ; 2 Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing 210093, China ; 3 Department of Respiratory Medicine, Nanjing Children's Hospital Affiliated with Nanjing Medical University, Nanjing 210008, China.
authors: Chun-Yang
authors: CY
authors: Yin
authors: 1 Department of Tuberculosis, Nanjing Chest Hospital, Nanjing 210029, China ; 2 Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing 210093, China ; 3 Department of Respiratory Medicine, Nanjing Children's Hospital Affiliated with Nanjing Medical University, Nanjing 210008, China.
authors: Chun-Mei
authors: CM
authors: Hu
authors: 1 Department of Tuberculosis, Nanjing Chest Hospital, Nanjing 210029, China ; 2 Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing 210093, China ; 3 Department of Respiratory Medicine, Nanjing Children's Hospital Affiliated with Nanjing Medical University, Nanjing 210008, China.
authors: Man
authors: M
authors: Tian
authors: 1 Department of Tuberculosis, Nanjing Chest Hospital, Nanjing 210029, China ; 2 Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing 210093, China ; 3 Department of Respiratory Medicine, Nanjing Children's Hospital Affiliated with Nanjing Medical University, Nanjing 210008, China.
authors: Hong-Wei
authors: HW
authors: Wang
authors: 1 Department of Tuberculosis, Nanjing Chest Hospital, Nanjing 210029, China ; 2 Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing 210093, China ; 3 Department of Respiratory Medicine, Nanjing Children's Hospital Affiliated with Nanjing Medical University, Nanjing 210008, China.
authors: Xia
authors: X
authors: Zhang
keywords: 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]; CD4/CD8 T lymphocytes; Tuberculosis (TB); clinical features