title: Structure-based characterization of multiprotein complexes.
abstract: Multiprotein complexes govern virtually all cellular processes. Their 3D structures provide important clues to their biological roles, especially through structural correlations among protein molecules and complexes. The detection of such correlations generally requires comprehensive searches in databases of known protein structures by means of appropriate structure-matching techniques. Here, we present a high-speed structure search engine capable of instantly matching large protein oligomers against the complete and up-to-date database of biologically functional assemblies of protein molecules. We use this tool to reveal unseen structural correlations on the level of protein quaternary structure and demonstrate its general usefulness for efficiently exploring complex structural relationships among known protein assemblies.
authors: Division of Structural Biology & Bioinformatics, Department of Molecular Biology, University of Salzburg, Hellbrunnerstraße 34, 5020 Salzburg, Austria. Electronic address: markII@came.sbg.ac.at.
authors: Markus
authors: M
authors: Wiederstein
authors: Division of Structural Biology & Bioinformatics, Department of Molecular Biology, University of Salzburg, Hellbrunnerstraße 34, 5020 Salzburg, Austria.
authors: Markus
authors: M
authors: Gruber
authors: Division of Structural Biology & Bioinformatics, Department of Molecular Biology, University of Salzburg, Hellbrunnerstraße 34, 5020 Salzburg, Austria.
authors: Karl
authors: K
authors: Frank
authors: Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, 8320000 Santiago, Chile; Molecular Bioinformatics Laboratory, Millennium Institute on Immunology and Immunotherapy, 8320000 Santiago, Chile.
authors: Francisco
authors: F
authors: Melo
authors: Division of Structural Biology & Bioinformatics, Department of Molecular Biology, University of Salzburg, Hellbrunnerstraße 34, 5020 Salzburg, Austria.
authors: Manfred J
authors: MJ
authors: Sippl
mesh_terms: D000465:Algorithms; D019295:Computational Biology / Q000379:methods*; D030562:Databases, Protein; D016247:Information Storage and Retrieval / Q000379:methods*; D020407:Internet; D008958:Models, Molecular; D046912:Multiprotein Complexes / Q000737:chemistry*; D011487:Protein Conformation; D020836:Protein Structure, Quaternary; D015203:Reproducibility of Results
chemical_list: D046912:Multiprotein Complexes