title: Dysfunction of affective network in post ischemic stroke depression: a resting-state functional magnetic resonance imaging study.
abstract: OBJECTIVE
  Previous studies have demonstrated that stroke characteristics and social and psychological factors jointly contribute to the development of poststroke depression (PSD). The purpose of this study was to identify altered functional connectivity (FC) of the affective network (AN) in patients with PSD and to explore the correlation between FC and the severity of PSD.
  
  
  METHODS
  26 PSD patients, 24 stroke patients without depression, and 24 age-matched normal controls underwent the resting-state functional MRI (fMRI) scanning. The bilateral anterior cingulated cortices (ACCs) were selected as regions of interest (ROIs). FC was calculated and compared among the three groups. The association between FC and Hamilton Depression Rate Scale (HDRS) scores of PSD group was investigated.
  
  
  RESULTS
  The FC of the AN was disrupted in PSD patients compared to stroke patients without depression and normal controls. Moreover, the left orbital part of inferior frontal gyrus which indicated altered FC was significantly correlated with HDRS scores in PSD patients.
  
  
  CONCLUSIONS
  Dysfunction of the affective network may be one of the reasons of the development of PSD.
authors: Department of Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantanxili, Dongcheng District, Beijing 100050, China.
authors: Peiyao
authors: P
authors: Zhang
authors: Centre for Studies of Psychological Application, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, School of Psychology, South China Normal University, Guangzhou, China.
authors: Qin
authors: 0000-0002-4481-3965
authors: Q
authors: Xu
authors: Department of Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantanxili, Dongcheng District, Beijing 100050, China.
authors: Jianping
authors: 0000-0001-8957-7954
authors: J
authors: Dai
authors: State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, 19 Xinjiekouwai Street, Haidian District, Beijing 100875, China ; Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, 19 Xinjiekouwai Street, Haidian District, Beijing 100875, China.
authors: Jun
authors: J
authors: Wang
authors: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantanxili, Dongcheng District, Beijing 100050, China.
authors: Ning
authors: N
authors: Zhang
authors: State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, 19 Xinjiekouwai Street, Haidian District, Beijing 100875, China ; Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, 19 Xinjiekouwai Street, Haidian District, Beijing 100875, China.
authors: Yuejia
authors: Y
authors: Luo
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging*; D002545:Brain Ischemia / Q000150:complications / Q000000981:diagnostic imaging*; D003863:Depression / Q000000981:diagnostic imaging* / Q000209:etiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000000981:diagnostic imaging*; D011446:Prospective Studies; D011859:Radiography; D020521:Stroke / Q000150:complications / Q000000981:diagnostic imaging*