title: Assessing the speed of kill of hookworms, Ancylostoma caninum, by Advantage Multi ® for Dogs using endoscopic methods.
abstract: Endoscopic capsules and endoscopy were used to assess the speed of kill and the clearance of hookworms in dogs experimentally infected with Ancylostoma caninum. A total of four adult dogs were inoculated in two separate cohorts comprised of two 4-year-old females and two 7-year-old males. Dogs were treated topically with Advantage Multi(®) for Dogs 13 days (Cohort 1) or 16 days (Cohort 2) after infection. Endoscopic imaging of the small intestine was carried out both pre- and post-treatment. Examination of the first cohort revealed that the worms had been cleared and the hookworm-induced lacerations were markedly diminished within 48 h of treatment. In the second cohort, endoscopic capsules were given the day of, the day after, and two days after treatment; within 24h of product administration, the worms had been removed with a concurrent reduction in observed lesions. Topical application of Advantage Multi(®) for Dogs rapidly removed worms from the small intestine of the dogs in this study as early as 24h post-treatment, with a marked reduction in the number of mucosal lesions seen.
authors: Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
authors: Alice C Y
authors: AC
authors: Lee
authors: Bayer HealthCare LLC, Veterinary Services, Shawnee Mission, KS, USA.
authors: Joseph A
authors: JA
authors: Hostetler
authors: Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA. Electronic address: ddb3@cornell.edu.
authors: Dwight D
authors: DD
authors: Bowman
mesh_terms: D000722:Ancylostoma / Q000187:drug effects; D000723:Ancylostomatoidea / Q000187:drug effects*; D000724:Ancylostomiasis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D000818:Animals; D015331:Cohort Studies; D004283:Dog Diseases / Q000188:drug therapy* / Q000469:parasitology; D004285:Dogs; D004724:Endoscopy / Q000662:veterinary; D005260:Female; D006725:Hookworm Infections / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D007093:Imidazoles / Q000008:administration & dosage*; D007700:Kinetics; D018942:Macrolides / Q000008:administration & dosage*; D008297:Male; D000073943:Neonicotinoids; D009574:Nitro Compounds / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D007093:Imidazoles; D018942:Macrolides; D000073943:Neonicotinoids; D009574:Nitro Compounds; C082359:imidacloprid; C027837:moxidectin
keywords: Ancylostoma; Endoscopic capsule; Endoscopy; Hookworms; In vivo; Lesions; Therapy