title: Refractive accuracy with light-adjustable intraocular lenses.
abstract: OBJECTIVE
  To evaluate efficacy, predictability, and stability of refractive treatments using light-adjustable intraocular lenses (IOLs).
  
  
  METHODS
  University Hospital Virgen de la Arrixaca, Murcia, Spain.
  
  
  METHODS
  Prospective nonrandomized clinical trial.
  
  
  METHODS
  Eyes with a light-adjustable IOL (LAL) were treated with spatial intensity profiles to correct refractive errors. The effective changes in refraction in the light-adjustable IOL after every treatment were estimated by subtracting those in the whole eye and the cornea, which were measured with a Hartmann-Shack sensor and a corneal topographer, respectively. The refractive changes in the whole eye and light-adjustable IOL, manifest refraction, and visual acuity were obtained after every light treatment and at the 3-, 6-, and 12-month follow-ups.
  
  
  RESULTS
  The study enrolled 53 eyes (49 patients). Each tested light spatial pattern (5 spherical; 3 astigmatic) produced a different refractive change (P<.01). The combination of 2 light adjustments induced a maximum change in spherical power of the light-adjustable IOL of between -1.98 diopters (D) and +2.30 D and in astigmatism of up to -2.68 D with axis errors below 9 degrees. Intersubject variability (standard deviation) ranged between 0.10 D and 0.40 D. The 2 required lock-in procedures induced a small myopic shift (range +0.01 to +0.57 D) that depended on previous adjustments.
  
  
  CONCLUSIONS
  Light-adjustable IOL implantation achieved accurate refractive outcomes (around emmetropia) with good uncorrected distance visual acuity, which remained stable over time. Further refinements in nomograms and in the treatment's protocol would improve the predictability of refractive and visual outcomes with these IOLs.
  
  
  BACKGROUND
  No author has a financial or proprietary interest in any material or method mentioned.
authors: From Laboratorio de Optica (Villegas, Alcon, Artal), Departamento de Física, Universidad de Murcia, and Servicio de Oftalmología (Rubio, Marín), Hospital Universitario Virgen de la Arrixaca El Palmar, Murcia, Spain. Electronic address: villegas@um.es.
authors: Eloy A
authors: EA
authors: Villegas
authors: From Laboratorio de Optica (Villegas, Alcon, Artal), Departamento de Física, Universidad de Murcia, and Servicio de Oftalmología (Rubio, Marín), Hospital Universitario Virgen de la Arrixaca El Palmar, Murcia, Spain.
authors: Encarna
authors: E
authors: Alcon
authors: From Laboratorio de Optica (Villegas, Alcon, Artal), Departamento de Física, Universidad de Murcia, and Servicio de Oftalmología (Rubio, Marín), Hospital Universitario Virgen de la Arrixaca El Palmar, Murcia, Spain.
authors: Elena
authors: E
authors: Rubio
authors: From Laboratorio de Optica (Villegas, Alcon, Artal), Departamento de Física, Universidad de Murcia, and Servicio de Oftalmología (Rubio, Marín), Hospital Universitario Virgen de la Arrixaca El Palmar, Murcia, Spain.
authors: José M
authors: JM
authors: Marín
authors: From Laboratorio de Optica (Villegas, Alcon, Artal), Departamento de Física, Universidad de Murcia, and Servicio de Oftalmología (Rubio, Marín), Hospital Universitario Virgen de la Arrixaca El Palmar, Murcia, Spain.
authors: Pablo
authors: P
authors: Artal
mesh_terms: D000328:Adult; D020811:Biomedical Technology / Q000379:methods; D003432:Cross-Linking Reagents / Q000528:radiation effects; D005260:Female; D006801:Humans; D019654:Lens Implantation, Intraocular / Q000379:methods*; D007910:Lenses, Intraocular; D008297:Male; D008875:Middle Aged; D055095:Optics and Photonics; D018918:Phacoemulsification; D058105:Polymerization / Q000528:radiation effects; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D012029:Refraction, Ocular / Q000502:physiology*; D012030:Refractive Errors / Q000517:prevention & control*; D015203:Reproducibility of Results; D014466:Ultraviolet Rays; D014792:Visual Acuity / Q000502:physiology
chemical_list: D003432:Cross-Linking Reagents