title: No association between genetic or epigenetic variation in insulin growth factors and antipsychotic-induced metabolic disturbances in a cross-sectional sample.
abstract: OBJECTIVE
  Second-generation antipsychotics (SGA) are known to induce metabolic disturbances. Genetic pathways, such as the IGF pathway could be associated with increased metabolic syndrome (MetS). Additionally, IGF2 methylation varies as a function of environmental influences and is associated with schizophrenia and MetS. The current study aims to evaluate whether genetic and epigenetic variation in genes of the IGF pathway are associated with metabolic disturbances in patients under treatment with SGAs.
  
  
  METHODS
  Cross-sectional metabolic data from 438 patients with schizophrenia spectrum disorder was analyzed. Using the Sequenom MassARRAY iPLEX(TM) platform, 27 SNPs of the IGF1 and IGF2 genes and the IGF receptors IGF1R and IGF2R were genotyped. Methylation status of seven IGF2 CpG dinucleotides was evaluated using a Sequenom MALDI-TOF spectrometer.
  
  
  CONCLUSIONS
  There was a significant association between IGF2 methylation and genotype, but no significant association between genetic or epigenetic variability and metabolic parameters in the present study.
authors: GRASP Research Unit, University Psychiatric Centre Catholic University Leuven, Herestraat 49, 3000 Leuven, Belgium.
authors: Tim
authors: T
authors: Moons
authors: Marc
authors: M
authors: De Hert
authors: Gunther
authors: G
authors: Kenis
authors: Wolfgang
authors: W
authors: Viechtbauer
authors: Jim
authors: J
authors: van Os
authors: Henning
authors: H
authors: Gohlke
authors: Stephan
authors: S
authors: Claes
authors: Ruud
authors: R
authors: van Winkel
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D019175:DNA Methylation / Q000235:genetics; D044127:Epigenesis, Genetic; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D007335:Insulin-Like Growth Factor II / Q000235:genetics*; D008297:Male; D024821:Metabolic Syndrome / Q000139:chemically induced / Q000235:genetics; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017526:Receptor, IGF Type 1 / Q000235:genetics*; D017527:Receptor, IGF Type 2 / Q000235:genetics*; D012559:Schizophrenia / Q000150:complications / Q000188:drug therapy / Q000235:genetics*
chemical_list: C583557:IGF1 protein, human; C035170:IGF2 protein, human; D017527:Receptor, IGF Type 2; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II; D017526:Receptor, IGF Type 1
keywords: IGF; antipsychotic; genetic variation; insulin growth factor; metabolic syndrome; methylation; schizophrenia