title: Sudden and isolated Broca's aphasia: a new clinical phenotype of anti NMDA receptor antibodies encephalitis in children.
abstract: BACKGROUND
  Anti NMDA receptor (anti NMDAR) encephalitis is a well-characterized entity in children associating movement disorders, psychiatric features and speech difficulties. Novel phenotypes have been described in adults.
  
  
  RESULTS
  A 4-year-old girl presented partial seizures which evolved towards sudden and isolated Broca's aphasia. Anti NMDAR antibodies were positive in CSF and serum confirming anti NMDAR encephalitis. Clinical recovery was observed after a specific treatment.
  
  
  CONCLUSIONS
  This case widens the clinical spectrum of anti-NMDAR encephalitis in children and awareness of this newly identified symptom is important as early treatment is a predictor of good outcome.
authors: Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Hôpital Bicêtre, Pediatric Neurology Department, Le Kremlin Bicêtre, France; National Referral Center for Neuro-Inflammatory Diseases in Children and University Paris-Sud, Le Kremlin-Bicêtre, France. Electronic address: kumaran.deiva@bct.aphp.fr.
authors: Kumaran
authors: K
authors: Deiva
authors: Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Hôpital Bicêtre, Pediatric Neurology Department, Le Kremlin Bicêtre, France.
authors: Maria Carmela
authors: MC
authors: Pera
authors: Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Hôpital Bicêtre, Pediatric Neurology Department, Le Kremlin Bicêtre, France.
authors: Hélène
authors: H
authors: Maurey
authors: Assistance Publique Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Hôpital Bicêtre, Immunology Department, Le Kremlin-Bicêtre, France.
authors: Pascale
authors: P
authors: Chrétien
authors: Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Biophysics and Nuclear Medecine Department, Le Kremlin-Bicêtre, France.
authors: Frédérique
authors: F
authors: Archambaud
authors: Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Neurophysiology and Epileptology Departement, Le Kremlin-Bicêtre, France.
authors: Viviane
authors: V
authors: Bouilleret
authors: Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Hôpital Bicêtre, Pediatric Neurology Department, Le Kremlin Bicêtre, France; National Referral Center for Neuro-Inflammatory Diseases in Children and University Paris-Sud, Le Kremlin-Bicêtre, France.
authors: Marc
authors: M
authors: Tardieu
mesh_terms: D060426:Anti-N-Methyl-D-Aspartate Receptor Encephalitis / Q000150:complications*; D001039:Aphasia, Broca / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology*; D002648:Child; D004569:Electroencephalography; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D049268:Positron-Emission Tomography; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate; D019788:Fluorodeoxyglucose F18
keywords: Auto immune; Broca's aphasia; Children; Epilepsy; NMDAR encephalitis