title: Epidemiology, clinical manifestations, and outcomes of Streptococcus suis infection in humans.
abstract: Streptococcus suis, a bacterium that affects pigs, is a neglected pathogen that causes systemic disease in humans. We conducted a systematic review and meta-analysis to summarize global estimates of the epidemiology, clinical characteristics, and outcomes of this zoonosis. We searched main literature databases for all studies through December 2012 using the search term "streptococcus suis." The prevalence of S. suis infection is highest in Asia; the primary risk factors are occupational exposure and eating of contaminated food. The pooled proportions of case-patients with pig-related occupations and history of eating high-risk food were 38.1% and 37.3%, respectively. The main clinical syndrome was meningitis (pooled rate 68.0%), followed by sepsis, arthritis, endocarditis, and endophthalmitis. The pooled case-fatality rate was 12.8%. Sequelae included hearing loss (39.1%) and vestibular dysfunction (22.7%). Our analysis identified gaps in the literature, particularly in assessing risk factors and sequelae of this infection.
authors: Vu Thi Lan
authors: VT
authors: Huong
authors: Ngo
authors: N
authors: Ha
authors: Nguyen Tien
authors: NT
authors: Huy
authors: Peter
authors: P
authors: Horby
authors: Ho Dang Trung
authors: HD
authors: Nghia
authors: Vu Dinh
authors: VD
authors: Thiem
authors: Xiaotong
authors: X
authors: Zhu
authors: Ngo Thi
authors: NT
authors: Hoa
authors: Tran Tinh
authors: TT
authors: Hien
authors: Javier
authors: J
authors: Zamora
authors: Constance
authors: C
authors: Schultsz
authors: Heiman Frank Louis
authors: HF
authors: Wertheim
authors: Kenji
authors: K
authors: Hirayama
mesh_terms: D000328:Adult; D000818:Animals; D016022:Case-Control Studies; D003141:Communicable Diseases / Q000453:epidemiology; D003430:Cross-Sectional Studies / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009790:Occupations; D012307:Risk Factors; D013290:Streptococcal Infections / Q000453:epidemiology*; D017011:Streptococcus suis; D034421:Sus scrofa / Q000382:microbiology; D013552:Swine / Q000382:microbiology; D015047:Zoonoses / Q000453:epidemiology*
keywords: Streptococcus suis; bacteria; bacterial meningitis; humans; meta-analysis; systematic review; zoonoses