title: Assessment of topiramate's efficacy and safety in epilepsy.
abstract: OBJECTIVE
  To study the significance of topiramate (TPM) addition on seizure control in treatment of epilepsy.
  
  
  METHODS
  A prospective open label add-on trial of TPM addition in patients with epilepsy was done. The events of baseline phase of 12 weeks followed by titration and maintenance phases were recorded. Assessment of the number of seizure and emergent adverse effects was done by a monthly visit for each case.
  
  
  METHODS
  Reduction of more than 50% mean seizure frequency or response ratio of 0.33 was taken as the criteria for responders.
  
  
  METHODS
  Normal Z-test for significance of differences between two proportions and Chi-square test for presence of association was applied and mean age, median duration, sex ratio, percentage prevalence were depicted.
  
  
  RESULTS
  Significant responses to TPM in both partial as well as generalized seizures were observed (Z = 6.66, P < 0.001 and Z = 4.185, P < 0.01). The effect was more pronounced in patients with partial seizures. However, the overall response was highly significant (Z = 7.839, P < 0.001). The best response was noted at the dose of 200-300 mg/day (Z = 6.708, P < 0.001). More than 35% cases of partial and generalized seizures reported more than 75% reduction levels. The drug was well tolerated in more than 65% cases for side effects on psychosis, giddiness, and anorexia. Mild side effects were seen only in about less than 35% cases.
  
  
  CONCLUSIONS
  TPM was found as a significantly effective add-on anticonvulsant with some limitation or mild side effects.
authors: Department of Pharmacology, All India Institute of Medical Sciences, Patna, Bihar, India.
authors: Prem P
authors: PP
authors: Gupta
authors: Department of Neurology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
authors: Anup Kumar
authors: AK
authors: Thacker
authors: Department of Pharmacology, Baba Raghav Das Medical College, Uttar Pradesh, India.
authors: Jamal
authors: J
authors: Haider
authors: Department of Pharmacology, Baba Raghav Das Medical College, Uttar Pradesh, India.
authors: Shilpi
authors: S
authors: Dhawan
authors: Department of Pharmacology, TMC, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India.
authors: Neerjesh
authors: N
authors: Pandey
authors: Department of Pharmacy, ITM, Gorakhpur, Uttar Pradesh, India.
authors: Awanish Kumar
authors: AK
authors: Pandey
keywords: Antiepileptic drug; seizures; topiramate