title: Use of a novel one-nostril mask-spacer device to evaluate airway hyperresponsiveness (AHR) in horses after chronic administration of albuterol.
abstract: Inflammatory airway disease (IAD) is very common in stabled horses. Short-acting beta agonist (SABA) drugs are often used to relieve clinical signs, although long-term exposure to these drugs may result in rebound bronchoconstriction. The purpose of this study was twofold: i) to describe the deposition of radiolabeled drugs using a novel one-nostril design mask-spacer combination with a breath-activated inhaler (BAI), and ii) to determine whether treatment for 10 d with inhaled albuterol using this device would impair the ability of albuterol to prevent bronchospasm during a histamine challenge test. The percentage of radio-aerosol deposited in the total lung was 12.39% ± 5.05%. All study horses demonstrated airway hyperresponsiveness (AHR) before enrollment in the study [mean provocative concentration eliciting 35% increase in delta flow (PC35) < 6 mg/mL histamine]. There was no significant difference in airway hyperresponsiveness to post-albuterol histamine challenge before or after treatment with albuterol. A 10-d treatment with placebo, however, caused a significant increase in airway hyperresponsiveness in all horses (P < 0.001). The results of this study show that the novel mask-spacer device was effective in delivering radiolabeled aerosolized drug to the lung and that delivery of a SABA for 10 d using this device did not result in increased airway hyperresponsiveness.
authors: Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts 01536, USA (Mazan, Hoffman); Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, Illinois 61801, USA (Lascola); Equine Health Studies Program, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana 70803, USA (Bruns).
authors: Melissa R
authors: MR
authors: Mazan
authors: Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts 01536, USA (Mazan, Hoffman); Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, Illinois 61801, USA (Lascola); Equine Health Studies Program, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana 70803, USA (Bruns).
authors: Kara
authors: K
authors: Lascola
authors: Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts 01536, USA (Mazan, Hoffman); Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, Illinois 61801, USA (Lascola); Equine Health Studies Program, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana 70803, USA (Bruns).
authors: Susan J
authors: SJ
authors: Bruns
authors: Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts 01536, USA (Mazan, Hoffman); Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, Illinois 61801, USA (Lascola); Equine Health Studies Program, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana 70803, USA (Bruns).
authors: Andrew M
authors: AM
authors: Hoffman
mesh_terms: D000280:Administration, Inhalation; D058666:Adrenergic beta-2 Receptor Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D000336:Aerosols; D000420:Albuterol / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001985:Bronchial Provocation Tests; D004334:Drug Administration Schedule; D005260:Female; D006632:Histamine / Q000008:administration & dosage / Q000494:pharmacology; D017442:Histamine Agonists / Q000008:administration & dosage / Q000494:pharmacology; D006736:Horses / Q000502:physiology*; D009330:Nebulizers and Vaporizers
chemical_list: D058666:Adrenergic beta-2 Receptor Agonists; D000336:Aerosols; D017442:Histamine Agonists; D006632:Histamine; D000420:Albuterol