title: Is granular formulation of lanthanum carbonate more effective than chewable tablets?
abstract: Maintenance dialysis patients at our hospital who had been receiving lanthanum carbonate (LC) chewable tablets were switched to the same dosage of the granules, and the differences in serum phosphorus (P) levels were compared, together with stratifying patients at the baseline characteristics. Compared to average serum P level of 5.48 mg/dL for 2 months prior to switching, the average level for 2 months after switching was 4.99 mg/dL (P = 0.049). For patients who were under 60, serum P levels were significantly improved after switching (P = 0.016), and for patients who were concomitantly taking many kinds of medications, a correlation to high reductions of serum P level after switching was shown (R = -0.635, P = 0.015). In order to maximize pharmaceutical potential of LC, we think that it is not only necessary to provide patients with how to take the medication, but it is also important to take into consideration the patients' baseline characteristics.
authors: Department of Nephrology, Mashiko Hospital, Saitama, Japan; Department of Internal Medicine, Division of Kidney and Hypertension, The Jikei University School of Medicine, Tokyo, Japan.
authors: Hidekazu
authors: H
authors: Okamoto
authors: Koutarou
authors: K
authors: Haruhara
authors: Sahoko
authors: S
authors: Kamejima
authors: Hana
authors: H
authors: Mafune
authors: Mayumi
authors: M
authors: Manabe
authors: Goh
authors: G
authors: Kanzaki
authors: Hiroshi
authors: H
authors: Mashiko
authors: Takashi
authors: T
authors: Yokoo
mesh_terms: D000328:Adult; D000368:Aged; D002626:Chemistry, Pharmaceutical; D005260:Female; D006801:Humans; D054559:Hyperphosphatemia / Q000188:drug therapy*; D007811:Lanthanum / Q000008:administration & dosage* / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D010758:Phosphorus / Q000097:blood*; D006435:Renal Dialysis; D012189:Retrospective Studies; D013607:Tablets
chemical_list: D013607:Tablets; D010758:Phosphorus; C119467:lanthanum carbonate; D007811:Lanthanum
keywords: Chewable Tablets; Granules; Lanthanum Carbonate; Patients' Baseline Characteristics; Serum Phosphorus Level