title: Familial urothelial cell carcinoma of the bladder with autosomal dominant inheritance and late onset phenotype.
abstract: OBJECTIVE
  Familial Urothelial cell bladder cancer is rare. We report two families with urothelial cell carcinoma (UCC) of bladder with family history in other relatives, displaying probable autosomal dominant inheritance and a late onset pure UCC phenotype, and document the phenotype in each family.
  
  
  METHODS
  Descriptive familial study on two pedigrees over three generations.
  
  
  RESULTS
  Two families with UCC bladder were identified, and the phenotype documented, each family having three cases of late onset UCC.
  
  
  CONCLUSIONS
  Some cases of UCC are hereditary and may display autosomal dominant inheritance with late onset of the cancer. Clinicians should be aware of the existence of a familial late onset UCC phenotype when managing cases of UCC.
authors: Department of Urological Surgery, Daisy Hill Hospital, 5 Hospital Road, Newry, BT35 8DR UK.
authors: Robin
authors: R
authors: Brown
authors: Department Genetic Medicine, Belfast HSC Trust, Lisburn Road, Belfast, BT9 7AB UK.
authors: Deirdre E
authors: DE
authors: Donnelly
authors: Department of Histopathology, Belfast HSC Trust, Lisburn Road, Belfast, BT9 7AB UK.
authors: Derek
authors: D
authors: Allen
authors: Department of Histopathology, Belfast HSC Trust, Lisburn Road, Belfast, BT9 7AB UK.
authors: Maurice B
authors: MB
authors: Loughrey
authors: Department Genetic Medicine, Belfast HSC Trust, Lisburn Road, Belfast, BT9 7AB UK ; Centre for Cancer Research and Cell Biology, Queens University of Belfast, 97 Lisburn Road, Belfast, BT9 7AE UK.
authors: Patrick J
authors: PJ
authors: Morrison
keywords: Autosomal dominant; Cancer; Urothelial cell bladder