title: [Neurocognitive endophenotypes in psychiatric genetics].
abstract: Psychiatric genetics aims to map genetic factors of psychiatric disorders with complex inheritance. The most commonly used phenotype is the categorical variable of the presence or absence of a disease (case-control model). However, the biological background of various psychiatric disease categories often overlaps. Thus, the use of endophenotypes based on specific biological mechanisms seems to be a more efficient approach in genetic association studies. Results confirm that categorical variables as phenotypes are statistically not so sensitive in identification of a genetic association as well-chosen endophenotypes. Current literature advocates a growing significance of analyzing dimensional neurocognitive endophenotypes in genetic association studies, as well as in developing diagnostic category systems with biological backgrounds.
authors: Eötvös Loránd Tudományegyetem, Pszichológiai Intézet, Budapest, Hungary. kotyeszter@gmail.com.
authors: Eszter
authors: E
authors: Kotyuk
authors: Mária
authors: M
authors: Sasvári-Szekely
authors: Anna
authors: A
authors: Székely
mesh_terms: D003071:Cognition; D003937:Diagnosis, Differential; D058068:Endophenotypes; D020022:Genetic Predisposition to Disease; D006801:Humans; D001523:Mental Disorders / Q000175:diagnosis* / Q000235:genetics*; D009483:Neuropsychological Tests