title: Nitroxide-loaded hexosomes provide MRI contrast in vivo.
abstract: The purpose of this work was to synthesize and screen, for their effectiveness to act as T1-enhancing magnetic resonance imaging (MRI) contrast agents, a small library of nitroxide lipids incorporated into cubic-phase lipid nanoparticles (cubosomes). The most effective nitroxide lipid was then formulated into lower-toxicity lipid nanoparticles (hexosomes), and effective MR contrast was observed in the aorta and spleen of live rats in vivo. This new class of lower-toxicity lipid nanoparticles allowed for higher relaxivities on the order of those of clinically used gadolinium complexes. The new hexosome formulation presented herein was significantly lower in toxicity and higher in relaxivity than cubosome formulations previously reported by us.
authors: National Trauma Research Institute, Alfred Hospital and Department of Surgery, Monash University , Melbourne 3000, Australia.
authors: Nicole
authors: N
authors: Bye
authors: Oliver E
authors: OE
authors: Hutt
authors: Tracey M
authors: TM
authors: Hinton
authors: Durga P
authors: DP
authors: Acharya
authors: Lynne J
authors: LJ
authors: Waddington
authors: Bradford A
authors: BA
authors: Moffat
authors: David K
authors: DK
authors: Wright
authors: Hong X
authors: HX
authors: Wang
authors: Xavier
authors: X
authors: Mulet
authors: Benjamin W
authors: BW
authors: Muir
mesh_terms: D000818:Animals; D001011:Aorta / Q000033:anatomy & histology; D016466:CHO Cells; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003287:Contrast Media / Q000138:chemical synthesis*; D003412:Cricetulus; D004912:Erythrocytes / Q000187:drug effects; D005233:Fatty Alcohols / Q000737:chemistry; D005260:Female; D005989:Glycerides / Q000737:chemistry; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D008810:Mice, Inbred C57BL; D009226:Myristates / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009589:Nitrogen Oxides / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013154:Spleen / Q000033:anatomy & histology
chemical_list: D003287:Contrast Media; D005233:Fatty Alcohols; D005989:Glycerides; D009226:Myristates; D009589:Nitrogen Oxides; C508873:3,7,11,15-tetramethyl-1,2,3-hexadecanetriol; C005953:monoolein; C039900:nitroxyl