title: Low-dose corticosteroid and gallium-67 scintigraphy and acute interstitial nephritis.
abstract: We describe a 19-year-old male who developed diclofenac-induced acute interstitial nephritis (AIN). Diffuse mononuclear cell infiltration was confirmed by renal biopsy and a Gallium (Ga)-67 scintigraphy revealed diffuse uptake of the isotope in both kidneys. His renal function had gradually and promptly recovered after initiation of low-dose prednisolone (0.5 mg/kg/day). There are no established criteria for the administration of corticosteroids in the treatment of drug-induced AIN. Moreover, no clear recommendations regarding the optimal dose and duration of steroid administration in the treatment for drug-induced AIN has been established. In addition, we discuss the clinical benefit of steroid treatment and the diagnostic impact of Ga scanning on the management of drug-induced AIN.
authors: Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Tochigi, Japan.
authors: Tetsu
authors: T
authors: Akimoto
authors: Ryoko
authors: R
authors: Horikoshi
authors: Shigeaki
authors: S
authors: Muto
authors: Eiji
authors: E
authors: Kusano
mesh_terms: D000208:Acute Disease; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D001706:Biopsy; D004008:Diclofenac / Q000009:adverse effects; D005710:Gallium Radioisotopes; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging* / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D009395:Nephritis, Interstitial / Q000139:chemically induced / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D011237:Predictive Value of Tests; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones; D000894:Anti-Inflammatory Agents, Non-Steroidal; D005710:Gallium Radioisotopes; D019275:Radiopharmaceuticals; D004008:Diclofenac