title: Fluorescent nanothermometers for intracellular thermal sensing.
abstract: The importance of high-resolution intracellular thermal sensing and imaging in the field of modern biomedicine has boosted the development of novel nanosized fluorescent systems (fluorescent nanothermometers) as the next generation of probes for intracellular thermal sensing and imaging. This thermal mapping requires fluorescent nanothermometers with good biocompatibility and high thermal sensitivity in order to obtain submicrometric and subdegree spatial and thermal resolutions, respectively. This review describes the different nanosized systems used up to now for intracellular thermal sensing and imaging. We also include the later advances in molecular systems based on fluorescent proteins for thermal mapping. A critical overview of the state of the art and the future perspective is also included.
authors: Fluorescence Imaging Group, Departamento de Física de Materiales, Universidad Autónoma de Madrid, 28049 Madrid, Spain.
authors: Daniel
authors: D
authors: Jaque
authors: Blanca Del
authors: BD
authors: Rosal
authors: Emma Martín
authors: EM
authors: Rodríguez
authors: Laura Martínez
authors: LM
authors: Maestro
authors: Patricia
authors: P
authors: Haro-González
authors: José García
authors: JG
authors: Solé
mesh_terms: D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D013696:Temperature; D013821:Thermometers
keywords: cellular temperature; fluorescent nanoparticle; nanotechnology; nanothermometry; single cell