title: Clinical efficacy of abatacept, tocilizumab, and etanercept in Japanese rheumatoid arthritis patients with inadequate response to anti-TNF monoclonal antibodies.
abstract: The aim of this study was to compare the efficacy and retention rates of three biologics (abatacept, tocilizumab, and etanercept) after switching from first-course anti-TNF monoclonal antibody therapy. We performed a retrospective multicenter study of 89 patients who underwent second-course biologic therapy for 52 weeks after switching from first-course anti-TNF monoclonal antibody therapy. Patients at baseline had a mean age of 58.7 years, mean disease duration of 9.8 years, and mean clinical disease activity index (CDAI) of 22.4. There was no significant difference between the three drugs, except in rheumatoid factor positivity. Retention rates for abatacept, tocilizumab, and etanercept treatment at 52 weeks were 72.0, 89.5 and 84.6 %, respectively. The evaluation of CDAI indicated no significant difference at 52 weeks among the three drugs. Discontinuation due to all unfavorable causes did not significantly differ among the three drugs in hazard ratio-based evaluations. Our results show that patients treated with abatacept, tocilizumab, and etanercept achieved a high response rate with no significant differences in drug retention rates and clinical efficacy. These drugs represent good therapeutic options for patients with RA who are refractory to anti-TNF monoclonal antibody therapy.
authors: Department of Orthopedic Surgery and Rheumatology, Nagoya University Hospital, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, Aichi, Japan.
authors: Shinya
authors: S
authors: Hirabara
authors: Nobunori
authors: N
authors: Takahashi
authors: Naoki
authors: N
authors: Fukaya
authors: Hiroyuki
authors: H
authors: Miyake
authors: Yuichiro
authors: Y
authors: Yabe
authors: Atsushi
authors: A
authors: Kaneko
authors: Takayasu
authors: T
authors: Ito
authors: Takeshi
authors: T
authors: Oguchi
authors: Daihei
authors: D
authors: Kida
authors: Yuji
authors: Y
authors: Hirano
authors: Takayoshi
authors: T
authors: Fujibayashi
authors: Fumiaki
authors: F
authors: Sugiura
authors: Masatoshi
authors: M
authors: Hayashi
authors: Koji
authors: K
authors: Funahashi
authors: Masahiro
authors: M
authors: Hanabayashi
authors: Shuji
authors: S
authors: Asai
authors: Naoki
authors: N
authors: Ishiguro
authors: Toshihisa
authors: T
authors: Kojima
mesh_terms: D000069594:Abatacept; D000328:Adult; D000368:Aged; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D057915:Drug Substitution; D000068800:Etanercept; D005260:Female; D006801:Humans; D018796:Immunoconjugates / Q000627:therapeutic use*; D007074:Immunoglobulin G / Q000627:therapeutic use*; D007564:Japan; D008297:Male; D008875:Middle Aged; D018124:Receptors, Tumor Necrosis Factor / Q000627:therapeutic use*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D018501:Antirheumatic Agents; D018796:Immunoconjugates; D007074:Immunoglobulin G; D018124:Receptors, Tumor Necrosis Factor; D000069594:Abatacept; C502936:tocilizumab; D000068800:Etanercept