title: Synthesis of functionalized chromones through sequential reactions in aqueous media.
abstract: An efficient sequential four-component reaction of chromone carbaldehydes, Meldrum's acid, 4-hydroxyl coumarin or 6-methyl-4-hydroxyl-pyrone and primary alcohols is reported which leads to 5a-i in aqueous media. Replacing the primary alcohol with isopropyl alcohol and tert-butyl alcohol results in different products 10 and 11. The environmentally friendly features, good to high yields and easy work-up are advantages of this approach.
authors: Peptide Chemistry Research Center, K. N. Toosi University of Technology, P. O. Box 15875-4416, Tehran, Iran. balalaie@kntu.ac.ir.
authors: Saber
authors: S
authors: Mehrparvar
authors: Saeed
authors: S
authors: Balalaie
authors: Mahnaz
authors: M
authors: Rabbanizadeh
authors: Frank
authors: F
authors: Rominger
authors: Elmira
authors: E
authors: Ghabraie
mesh_terms: D000440:Butanols / Q000737:chemistry; D002867:Chromones / Q000138:chemical synthesis* / Q000737:chemistry*; D008968:Molecular Conformation; D014867:Water / Q000737:chemistry*
chemical_list: D000440:Butanols; D002867:Chromones; D014867:Water