title: Coupled forward-adjoint Monte Carlo simulation of spatial-angular light fields to determine optical sensitivity in turbid media.
abstract: We present a coupled forward-adjoint Monte Carlo (cFAMC) method to determine the spatially resolved sensitivity distributions produced by optical interrogation of three-dimensional (3-D) tissue volumes. We develop a general computational framework that computes the spatial and angular distributions of the forward-adjoint light fields to provide accurate computations in mesoscopic tissue volumes. We provide full computational details of the cFAMC method and provide results for low- and high-scattering tissues probed using a single pair of optical fibers. We examine the effects of source-detector separation and orientation on the sensitivity distributions and consider how the degree of angular discretization used in the 3-D tissue model impacts the accuracy of the resulting absorption sensitivity profiles. We discuss the value of such computations for optical imaging and the design of optical measurements.
authors: Beckman Laser Institute, Laser Microbeam and Medical Program, 1002 Health Sciences Road, Irvine, California 92697-3010bUniversity of California, Department of Chemical Engineering and Materials Science, 916 Engineering Tower, Irvine, California 92697-2575.
authors: Adam R
authors: AR
authors: Gardner
authors: Beckman Laser Institute, Laser Microbeam and Medical Program, 1002 Health Sciences Road, Irvine, California 92697-3010bUniversity of California, Department of Chemical Engineering and Materials Science, 916 Engineering Tower, Irvine, California 92697-2575.
authors: Carole K
authors: CK
authors: Hayakawa
authors: Beckman Laser Institute, Laser Microbeam and Medical Program, 1002 Health Sciences Road, Irvine, California 92697-3010bUniversity of California, Department of Chemical Engineering and Materials Science, 916 Engineering Tower, Irvine, California 92697-2575.
authors: Vasan
authors: V
authors: Venugopalan
mesh_terms: D000465:Algorithms; D016880:Anisotropy; D003198:Computer Simulation; D003952:Diagnostic Imaging / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D021621:Imaging, Three-Dimensional; D008027:Light; D009010:Monte Carlo Method; D009391:Nephelometry and Turbidimetry; D055100:Optical Fibers; D055095:Optics and Photonics; D011336:Probability; D012542:Scattering, Radiation; D012984:Software