title: Two-hybrid and its recent adaptations.
abstract: Interactions between proteins play a pivotal role in virtually all cellular processes, and many of these interactions represent interesting targets for drug development. Among the wide array of interactor-hunting technologies that has emerged, genetic two-hybrid methods account for a large amount of the currently available interaction data and is being successfully applied in interactome-scale mapping projects. Reverse two-hybrid approaches have been developed that allow selected interactions to be assayed for disrupting compounds.:
authors: Flanders Interuniversity Institute for Biotechnology (VIB), Department of Medical Protein Research, Ghent University, Faculty of Medicine and Health Sciences, A. Baertsoenkaai 3, 9000 Ghent, Belgium.
authors: Sam
authors: S
authors: Lievens
authors: Flanders Interuniversity Institute for Biotechnology (VIB), Department of Medical Protein Research, Ghent University, Faculty of Medicine and Health Sciences, A. Baertsoenkaai 3, 9000 Ghent, Belgium.
authors: Irma
authors: I
authors: Lemmens
authors: Flanders Interuniversity Institute for Biotechnology (VIB), Department of Medical Protein Research, Ghent University, Faculty of Medicine and Health Sciences, A. Baertsoenkaai 3, 9000 Ghent, Belgium.
authors: Tony
authors: T
authors: Montoye
authors: Flanders Interuniversity Institute for Biotechnology (VIB), Department of Medical Protein Research, Ghent University, Faculty of Medicine and Health Sciences, A. Baertsoenkaai 3, 9000 Ghent, Belgium.
authors: Sven
authors: S
authors: Eyckerman
authors: Flanders Interuniversity Institute for Biotechnology (VIB), Department of Medical Protein Research, Ghent University, Faculty of Medicine and Health Sciences, A. Baertsoenkaai 3, 9000 Ghent, Belgium. Electronic address:jan.tavernier@ugent.be.
authors: Jan
authors: J
authors: Tavernier