title: Recent insights into the pathophysiology of omental metastases.
abstract: Although, useful in inflammatory conditions, the greater omentum represents an important site of metastasis in peritoneal carcinomatosis and is therefore frequently removed as a staging or therapeutic tool. Apart from the milky spots, omental adipose stem cells, and adipocytes have recently been identified to play a role in the preferential homing of tumor cells to the omentum. The extent of omentectomy and whether a routine omentectomy should be done are still known unknowns.
authors: Department of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Surgery, Ghent University Hospital, Ghent, Belgium.
authors: Manuel J
authors: MJ
authors: Koppe
authors: Iris D
authors: ID
authors: Nagtegaal
authors: Johannes H W
authors: JH
authors: de Wilt
authors: Wim P
authors: WP
authors: Ceelen
mesh_terms: D017667:Adipocytes / Q000502:physiology; D000818:Animals; D001201:Ascites / Q000503:physiopathology; D002448:Cell Adhesion / Q000502:physiology; D006801:Humans; D008264:Macrophages / Q000502:physiology; D059630:Mesenchymal Stem Cells / Q000502:physiology; D009366:Neoplasm Seeding; D009852:Omentum; D010534:Peritoneal Neoplasms / Q000503:physiopathology* / Q000556:secondary* / Q000601:surgery
keywords: adipocytes; adipose stem cells; milky spots; omental metastases; pathophysiology