title: Oligomeric nanoparticles functionalized with NIR-emitting CdTe/CdS QDs and folate for tumor-targeted imaging.
abstract: We report herein the facile surface-functionalization of one type of biocompatible, oligomeric nanoparticles 1-NPs with NIR-emitting CdTe/CdS QDs and folate for tumor-targeted imaging in vivo. The -NH2 and -SH groups of cysteine residues on the 1-NPs were utilized to covalently conjugate CdTe/CdS QDs and Mal-FA to prepare the hybrid nanoparticles 1-NPs-QDs-FA. As-prepared 1-NPs-QDs-FA showed NIR-fluorescence emission at 734 nm, selective uptake by FR-overexpressing tumor cells in vitro, and selective FR-overexpressing tumor-targeted imaging in vivo. This first example of oligomeric/inorganic hybrid nanoparticles provides people with new type of biomaterials for tumor-targeted imaging with high selectivity.
authors: CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry & Collaborative Innovation Center of Suzhou Nano Science and Technology, University of Science and Technology of China, Hefei, Anhui 230026, China.
authors: Yue
authors: Y
authors: Yuan
authors: CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry & Collaborative Innovation Center of Suzhou Nano Science and Technology, University of Science and Technology of China, Hefei, Anhui 230026, China.
authors: Jia
authors: J
authors: Zhang
authors: CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry & Collaborative Innovation Center of Suzhou Nano Science and Technology, University of Science and Technology of China, Hefei, Anhui 230026, China.
authors: Linna
authors: L
authors: An
authors: CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry & Collaborative Innovation Center of Suzhou Nano Science and Technology, University of Science and Technology of China, Hefei, Anhui 230026, China.
authors: Qinjingwen
authors: Q
authors: Cao
authors: CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry & Collaborative Innovation Center of Suzhou Nano Science and Technology, University of Science and Technology of China, Hefei, Anhui 230026, China.
authors: Yun
authors: Y
authors: Deng
authors: CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry & Collaborative Innovation Center of Suzhou Nano Science and Technology, University of Science and Technology of China, Hefei, Anhui 230026, China. Electronic address: gliang@ustc.edu.cn.
authors: Gaolin
authors: G
authors: Liang
mesh_terms: D000818:Animals; D019187:Cadmium Compounds / Q000138:chemical synthesis / Q000737:chemistry; D003952:Diagnostic Imaging / Q000379:methods*; D005453:Fluorescence; D005492:Folic Acid / Q000737:chemistry; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009369:Neoplasms / Q000175:diagnosis* / Q000473:pathology; D061848:Optical Imaging; D009928:Organ Specificity; D045663:Quantum Dots / Q000737:chemistry*; D019265:Spectroscopy, Near-Infrared; D013440:Sulfides / Q000138:chemical synthesis / Q000737:chemistry; D013691:Tellurium / Q000737:chemistry
chemical_list: D019187:Cadmium Compounds; D013440:Sulfides; C034939:cadmium sulfide; D005492:Folic Acid; D013691:Tellurium; C028337:cadmium telluride
keywords: Hybrid nanoparticles; Imaging; Near-infrared; Oligomeric nanoparticles; Quantum dots; Tumor-targeting