title: From membranes to organelles: emerging roles for dynamin-like proteins in diverse cellular processes.
abstract: Dynamin is a GTPase mechanoenzyme most noted for its role in vesicle scission during endocytosis, and belongs to the dynamin family proteins. The dynamin family consists of classical dynamins and dynamin-like proteins (DLPs). Due to structural and functional similarities DLPs are thought to carry out membrane tubulation and scission in a similar manner to dynamin. Here, we discuss the newly emerging roles for DLPs, which include vacuole fission and fusion, peroxisome maintenance, endocytosis and intracellular trafficking. Specific focus is given to the role of DLPs in the budding yeast Saccharomyces cerevisiae because the diverse function of DLPs has been well characterized in this organism. Recent insights into DLPs may provide a better understanding of mammalian dynamin and its associated diseases.
authors: Department of Biology, Missouri State University, 901 South National, Springfield, MO 65897, United States.
authors: Michelle
authors: M
authors: Williams
authors: Department of Biology, Missouri State University, 901 South National, Springfield, MO 65897, United States. Electronic address: kkim@missouristate.edu.
authors: Kyoungtae
authors: K
authors: Kim
mesh_terms: D034281:Dynamins / Q000378:metabolism*; D004705:Endocytosis; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism; D015388:Organelles / Q000378:metabolism*; D020675:Peroxisomes / Q000378:metabolism; D021381:Protein Transport; D012441:Saccharomyces cerevisiae / Q000378:metabolism* / Q000648:ultrastructure
chemical_list: D034281:Dynamins
keywords: Dynamin-like protein; Endocytosis; Intracellular trafficking; Peroxisome; Scission; Tubulation; Vacuole; Vps1