title: Systematic review of minimally invasive ablation treatment for locally advanced pancreatic cancer.
abstract: Unresectable locally advanced pancreatic cancer with or without metastatic disease is associated with a very poor prognosis. Ablation techniques are based on direct application of chemical, thermal, or electrical energy to a tumor, which leads to cellular necrosis. Initial studies about ablation therapies of the pancreas were associated with significant morbidity and mortality, which limited widespread adoption. Modifications to the various applications, in particular combining the techniques with high-quality imaging and intra-operative approach has enabled real-time treatment monitoring and significant improvements in safety. Inoperable cases of pancreatic cancer have been treated by various ablation techniques in the last few years with promising results. The purpose of this review is to present the current status of local ablative therapies in the treatment of pancreatic advanced tumor.
authors: Department of Radiology, Interventional Radiology, Insubria University, Viale Borri, 57, 21100, Varese, Italy.
authors: Anna Maria
authors: AM
authors: Ierardi
authors: Natalie
authors: N
authors: Lucchina
authors: Mario
authors: M
authors: Petrillo
authors: Chiara
authors: C
authors: Floridi
authors: Filippo
authors: F
authors: Piacentino
authors: Alessandro
authors: A
authors: Bacuzzi
authors: Paolo
authors: P
authors: Fonio
authors: Federico
authors: F
authors: Fontana
authors: Carlo
authors: C
authors: Fugazzola
authors: Luca
authors: L
authors: Brunese
authors: Gianpaolo
authors: G
authors: Carrafiello
mesh_terms: D055011:Ablation Techniques; D018274:Electroporation / Q000379:methods; D006801:Humans; D019060:Minimally Invasive Surgical Procedures; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000473:pathology / Q000601:surgery*; D011183:Postoperative Complications; D015641:Radiography, Interventional