title: [Pd(μ-Cl)Cl(IPr*)]2: a highly hindered pre-catalyst for the synthesis of tetra-ortho-substituted biaryls via Grignard reagent cross-coupling.
abstract: The new well-defined catalyst [Pd(μ-Cl)Cl(IPr*)]2 enables the efficient Grignard reagent cross-coupling for the synthesis of tetra-ortho-substituted biaryls. The high reactivity of the complex is associated with the important bulkiness of the IPr* ligand. The dimer represents the most efficient catalyst reported to date for this challenging transformation.
authors: EaStCHEM School of Chemistry, University of St Andrews, St Andrews, KY16 9ST, UK. cc111@st-andrews.ac.uk.
authors: Mathieu
authors: M
authors: Lesieur
authors: Alexandra M Z
authors: AM
authors: Slawin
authors: Catherine S J
authors: CS
authors: Cazin
mesh_terms: D001713:Biphenyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry*; D007202:Indicators and Reagents / Q000737:chemistry*; D008024:Ligands; D008958:Models, Molecular; D008968:Molecular Conformation; D010165:Palladium / Q000737:chemistry*
chemical_list: D001713:Biphenyl Compounds; D056831:Coordination Complexes; D007202:Indicators and Reagents; D008024:Ligands; D010165:Palladium