title: Serum leukotrienes, circulating neutrophils, and high sensitivity C-reactive protein in Chinese children with sleep-disordered breathing.
abstract: BACKGROUND
  A number of previous works have shown that leukotriene (LT) concentration emerged disease severity-dependent increases in both exhaled breath condensate and urine of sleep-disordered breathing (SDB) patients. However, few studies have investigated how circulating level of LTs contributes to systemic inflammation of SDB, and the relationship between LT production, leukocyte count and high sensitivity C-reactive protein (hsCRP) level in SDB disease remains controversial.
  
  
  METHODS
  Prospective, observational study that included standard questionnaires, physical examinations and polysomnography. Serum leukotriene B4 (LTB(4)) and cysteinyl leukotrienes (cysLTs) were determined by means of enzyme-linked immunosorbent assays.
  
  
  RESULTS
  A total of 166 children with SDB and 45 control subjects were recruited. SDB children had increased serum levels for both LTB(4) and cysLTs as well as neutrophil (Neu) count and hsCRP than the control group, and all the inflammatory parameters emerged disease severity-dependent increases. LT production correlated significantly with Neu count and hsCRP level. In the regression model, both apnea-hypopnea index and body mass index z-score were significant predictors of LTB(4) and cysLTs (p < 0.001).
  
  
  CONCLUSIONS
  The activated systemic inflammatory response as reflected by serum elevations of LTs, Neu counts and hsCRP is present in children with SDB, and the magnitude of inflammation emerged disease severity-dependent. The level of LTs is significantly associated with circulating Neu counts and hsCRP values in SDB.
authors: Department No. 2 of Respiratory Medicine, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing, People's Republic of China.
authors: Yuelin
authors: Y
authors: Shen
authors: Department No. 1 of Respiratory Medicine, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing, People's Republic of China.
authors: Qiang
authors: Q
authors: Qin
authors: Department of Sleep Center, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing, People's Republic of China.
authors: Zhifei
authors: Z
authors: Xu
authors: Department No. 1 of Respiratory Medicine, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing, People's Republic of China. Electronic address: kunlingshen1717@163.com.
authors: Kunling
authors: K
authors: Shen
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism*; D002452:Cell Count; D002648:Child; D002675:Child, Preschool; D002681:China; D018450:Disease Progression; D006801:Humans; D007975:Leukotriene B4 / Q000097:blood*; D009504:Neutrophils / Q000276:immunology*; D017286:Polysomnography; D011379:Prognosis; D011446:Prospective Studies; D018077:Receptors, Leukotriene / Q000378:metabolism*; D012119:Respiration; D012891:Sleep Apnea Syndromes / Q000175:diagnosis* / Q000276:immunology
chemical_list: D018077:Receptors, Leukotriene; D007975:Leukotriene B4; D002097:C-Reactive Protein; C083169:leukotriene D4 receptor
keywords: Cysteinyl leukotrienes; High sensitivity C-reactive protein; Leukotriene B(4); Neutrophil; Sleep-disordered breathing; Systemic inflammation