title: Structure-activity relationship study of dibenzocyclooctadiene lignans isolated from Schisandra chinensis on lipopolysaccharide-induced microglia activation.
abstract: To explore the relationship of the dibenzocyclooctadiene lignans from Schisandra chinensis to their anti-inflammatory activities, series of dibenzocyclooctadiene lignans were isolated and assessed by testing their inhibitory effects on nitric oxide production in lipopolysaccharide-induced BV2 mouse microglia. It was found, for the first time, that dibenzocyclooctadiene lignans which have S-biphenyl and methylenedioxy groups strongly inhibited LPS-induced microglia activation. The methoxy group on the cyclooctadiene introduced more effectiveness, but the presence of an acetyl group on the cyclooctadiene or hydroxyl group on C-7 decreased the inhibitory activity.
authors: Development and Utilization Key Laboratory of Northeast Plant Materials of Liaoning Province, Department of Pharmacognosy, Shenyang Pharmaceutical University, Shenyang, China.
authors: Di
authors: D
authors: Hu
authors: Development and Utilization Key Laboratory of Northeast Plant Materials of Liaoning Province, Department of Pharmacognosy, Shenyang Pharmaceutical University, Shenyang, China.
authors: Na
authors: N
authors: Han
authors: Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China.
authors: Xuechun
authors: X
authors: Yao
authors: Development and Utilization Key Laboratory of Northeast Plant Materials of Liaoning Province, Department of Pharmacognosy, Shenyang Pharmaceutical University, Shenyang, China.
authors: Zhihui
authors: Z
authors: Liu
authors: The Chinese People's Liberation Army 463 Hospital, Shenyang, China.
authors: Yu
authors: Y
authors: Wang
authors: Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China.
authors: Jingyu
authors: J
authors: Yang
authors: Development and Utilization Key Laboratory of Northeast Plant Materials of Liaoning Province, Department of Pharmacognosy, Shenyang Pharmaceutical University, Shenyang, China.
authors: Jun
authors: J
authors: Yin
mesh_terms: D000818:Animals; D002460:Cell Line; D034242:Cyclooctanes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000009:adverse effects*; D051379:Mice; D017628:Microglia / Q000187:drug effects*; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D032141:Schisandra / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D034242:Cyclooctanes; D017705:Lignans; D008070:Lipopolysaccharides; D010936:Plant Extracts; C510994:dibenzocyclooctadiene lignan; D009569:Nitric Oxide