title: Massive pulmonary embolism in a young boy with T-cell leukaemia. Successful thrombolytic therapy by recombinant tissue plasminogen activator (rtPA).
abstract: Acute pulmonary embolism (PE) is a serious complication in association with malignant diseases. We describe the successful treatment of PE applying a systemic thrombolytic therapy in a 4-year-old boy with acute lymphoblastic leukaemia. The thrombolytic therapy with recombinant tissue plasminogen activator (rtPA) 0.1 mg/kg bodyweight per hour for six hours was continued for six days without important side effects. In particular no bleeding complications were observed. Computed tomography with contrast revealed a remarkable regression of the central PE. Without further delays the chemotherapy was resumed.
authors: Olaf Beck, MD, Children`s Hospital, Paediatric Haematology and Oncology, Johannes Gutenberg-University Mainz, Langenbeckstr. 1, 55131 Mainz, Germany, Tel. +49/(0)61 31/17 35 20, Fax +49/(0)61 31/17 64 69, E-mail: obeck@uni-mainz.de.
authors: O
authors: O
authors: Beck
authors: C
authors: C
authors: Martin
authors: F
authors: F
authors: Alt
authors: A
authors: A
authors: Wingerter
authors: G
authors: G
authors: Staatz
authors: H
authors: H
authors: Schinzel
authors: J
authors: J
authors: Faber
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D005343:Fibrinolytic Agents / Q000008:administration & dosage; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage*; D006801:Humans; D015458:Leukemia, T-Cell / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D011655:Pulmonary Embolism / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D011994:Recombinant Proteins / Q000008:administration & dosage; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D005343:Fibrinolytic Agents; D006495:Heparin, Low-Molecular-Weight; D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator
keywords: Pulmonary embolism; children; leukaemia; recombinant tissue plasminogen activator; rtPA