title: Stimulating effect of a new triterpene derived from Anoectochilus elwesii on glucose uptake in insulin-resistant human HepG2 cells.
abstract: A new triterpene (1), 3-β-O-olean-11,13 (18)-diene-23,28-dioic acid, together with five known compounds (2-6), was isolated from Anoectochilus elwesii and their structures were elucidated by extensive spectroscopic methods and comparison with the literature data. Compound 1 was the first example of highly oxygenated triterpene obtained from Anoectochilus genus. The isolated compounds were evaluated on insulin-resistant human HepG2 cells for stimulating glucose uptake activity and the new compound displayed highly potent effect on the stimulation of glucose uptake in human HepG2 cells.
authors: a School of Pharmacy, Guangdong Pharmaceutical University , Guangzhou 510006 , P.R. China.
authors: Jinyan
authors: J
authors: Cai
authors: Lin
authors: L
authors: Zhao
authors: En
authors: E
authors: Zhu
authors: Jiao
authors: J
authors: Guo
mesh_terms: D001692:Biological Transport; D002470:Cell Survival / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism*; D056945:Hep G2 Cells; D006801:Humans; D007333:Insulin Resistance; D023421:Models, Animal; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D029595:Orchidaceae / Q000737:chemistry*
chemical_list: C000595391:3-beta-O-olean-11,13(18)-diene-23,28-dioic acid; D004365:Drugs, Chinese Herbal; D009828:Oleanolic Acid; D005947:Glucose
keywords: Anoectochilus elwesii; insulin-resistant human HepG2 cells; triterpene