title: Evolution of TRP channels inferred by their classification in diverse animal species.
abstract: The functions of TRP channels have primarily been characterized in model organisms within a limited evolutionary context. We thus characterize the TRP channels in choanoflagellate, sponge, Cnidaria, Lophotrochozoa, and arthropods to understand how they emerged during early evolution of animals and have changed during diversification of various species. As previously reported, five metazoan TRP subfamily members (TRPA, TRPC, TRPM, TRPML, and TRPV) were identified in choanoflagellates, demonstrating that they evolved before the emergence of multicellular animals. TRPN was identified in Hydra magnipapillata, and therefore emerged in the last common ancestor of Cnidaria-Bilateria. A novel subfamily member (TRPVL) was identified in Cnidaria and Capitella teleta, indicating that it was present in the last common ancestor of Cnidaria-Bilateria but has since been lost in most bilaterians. The characterization of arthropod TRP channels revealed that Daphnia pulex and insects have specifically expanded the TRPA subfamily, which diverged from the ancient TRPA1 channel gene. The diversity of TRPA channels except TRPA1 was detectable even within a single insect family, namely the ant lineage. The present study demonstrates the evolutionary history of TRP channel genes, which may have diverged in conjunction with the specific habitats and life histories of individual species.
authors: Department of Biological Sciences, Xi'an Jiaotong-Liverpool University, 111 Ren'ai Road, Suzhou Dushu Lake Higher Education Town, Jiangsu Province 215123, China.
authors: Guangda
authors: G
authors: Peng
authors: Department of Biological Sciences, Xi'an Jiaotong-Liverpool University, 111 Ren'ai Road, Suzhou Dushu Lake Higher Education Town, Jiangsu Province 215123, China.
authors: Xiao
authors: X
authors: Shi
authors: Department of Biological Sciences, Xi'an Jiaotong-Liverpool University, 111 Ren'ai Road, Suzhou Dushu Lake Higher Education Town, Jiangsu Province 215123, China. Electronic address: Tatsuhiko.Kadowaki@xjtlu.edu.cn.
authors: Tatsuhiko
authors: T
authors: Kadowaki
mesh_terms: D000818:Animals; D005075:Biological Evolution; D007448:Invertebrates / Q000235:genetics; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D050051:Transient Receptor Potential Channels / Q000145:classification*
chemical_list: D050051:Transient Receptor Potential Channels
keywords: Arthropoda; Choanoflagellate; Cnidaria; Lophotrochozoa; Sponge; TRP channel