title: Bone marrow stem cells added to a hydroxyapatite scaffold result in better outcomes after surgical treatment of intertrochanteric hip fractures.
abstract: BACKGROUND
  Intertrochanteric hip fractures occur in the proximal femur. They are very common in the elderly and are responsible for high rates of morbidity and mortality. The authors hypothesized that adding an autologous bone marrow stem cells concentrate (ABMC) to a hydroxyapatite scaffold and placing it in the fracture site would improve the outcome after surgical fixation of intertrochanteric hip fractures.
  
  
  METHODS
  30 patients were randomly selected and divided into 2 groups of 15 patients, to receive either the scaffold enriched with the ABMC (Group A) during the surgical procedure, or fracture fixation alone (Group B).
  
  
  RESULTS
  There was a statistically significant difference in favor of group A at days 30, 60, and 90 for Harris Hip Scores (HHS), at days 30 and 60 for VAS pain scales, for bedridden period and time taken to start partial and total weight bearing (P < 0.05).
  
  
  CONCLUSIONS
  These results show a significant benefit of adding a bone marrow enriched scaffold to surgical fixation in intertrochanteric hip fractures, which can significantly reduce the associated morbidity and mortality rates.
  
  
  CONCLUSIONS
  Bone marrow stem cells added to a hydroxyapatite scaffold result in better outcomes after surgical treatment of intertrochanteric hip fractures.
authors: Faculty of Medicine, University of Porto, Alameda Hernani Monteiro, 4200-319 Porto, Portugal ; Hospital S. Joao, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal.
authors: Joao
authors: 0000-0001-9927-1158
authors: J
authors: Torres
authors: Faculty of Medicine, University of Porto, Alameda Hernani Monteiro, 4200-319 Porto, Portugal ; Hospital S. Joao, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal.
authors: Manuel
authors: M
authors: Gutierres
authors: CEMUC, Faculdade de Engenharia, Universidade do Porto, Rua Doutor Roberto Frias, 4200-465 Porto, Portugal.
authors: M Ascenção
authors: MA
authors: Lopes
authors: CEMUC, Faculdade de Engenharia, Universidade do Porto, Rua Doutor Roberto Frias, 4200-465 Porto, Portugal.
authors: J Domingos
authors: JD
authors: Santos
authors: Faculty of Medicine, University of Porto, Alameda Hernani Monteiro, 4200-319 Porto, Portugal ; Hospital S. Joao, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal.
authors: A T
authors: AT
authors: Cabral
authors: Hospital S. Joao, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal.
authors: R
authors: R
authors: Pinto
authors: Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, 3471 Fifth Avenue, Kaufman building suite 1011, Pittsburgh, PA 15213, USA.
authors: Carola
authors: 0000-0002-6657-0001
authors: C
authors: van Eck
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001854:Bone Marrow Cells / Q000737:chemistry / Q000378:metabolism*; D017886:Durapatite / Q000008:administration & dosage* / Q000737:chemistry; D005260:Female; D005269:Femur / Q000601:surgery; D006620:Hip Fractures / Q000473:pathology / Q000601:surgery* / Q000628:therapy*; D006801:Humans; D008297:Male; D011182:Postoperative Care; D013234:Stem Cells / Q000737:chemistry / Q000378:metabolism*; D016896:Treatment Outcome
chemical_list: D017886:Durapatite