title: Top-down synthesized TiO2 nanowires as a solid matrix for surface-assisted laser desorption/ionization time-of-flight (SALDI-TOF) mass spectrometry.
abstract: Top-down synthesized TiO2 nanowires are presented as an ideal solid matrix to analyze small biomolecules at a m/z of less than 500. The TiO2 nanowires were synthesized as arrays using a modified hydrothermal process directly on the surface of a Ti plate. Finally, the feasibility of the TiO2 nanowires in the anatase phase as a solid matrix. The crystal and electronic structures of the top-down TiO2 nanowires were analyzed at each step of the hydrothermal process, and the optimal TiO2 nanowires were identified by checking their performance toward the ionization of analytes in surface-assisted laser desorption/ionization time-of-flight (SALDI-TOF) mass spectrometry. Finally, the feasibility of the TiO2 nanowires in the anatase phase as a solid matrix for SALDI-TOF mass spectrometry was demonstrated using eight types of amino acids and peptides as model analytes.
authors: Department of Materials Science and Engineering, Yonsei University, Seoul, Republic of Korea.
authors: Jo-Il
authors: JI
authors: Kim
authors: Department of Materials Science and Engineering, Yonsei University, Seoul, Republic of Korea.
authors: Jong-Min
authors: JM
authors: Park
authors: Department of Chemistry, Ewha Womans University, Seoul, Republic of Korea.
authors: Seung-Ju
authors: SJ
authors: Hwang
authors: Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
authors: Min-Jung
authors: MJ
authors: Kang
authors: Department of Materials Science and Engineering, Yonsei University, Seoul, Republic of Korea. Electronic address: jcpyun@yonsei.ac.kr.
authors: Jae-Chul
authors: JC
authors: Pyun
mesh_terms: D000596:Amino Acids / Q000032:analysis; D003460:Crystallization; D053770:Nanowires / Q000737:chemistry*; D010455:Peptides / Q000032:analysis; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000295:instrumentation / Q000379:methods*; D014025:Titanium / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D010455:Peptides; C009495:titanium dioxide; D014025:Titanium
keywords: Anatase; Mass spectrometry; Nanowires; SALDI-TOF; Solid matrix; TiO(2)