title: Lost in translation? Role of metabolomics in solving translational problems in drug discovery and development.
abstract: Too few drug discovery projects generate a marketed drug product, often because preclinical studies fail to predict the clinical experience with a drug candidate. Improving the success of preclinical-to-clinical translation is of paramount importance in optimizing the pharmaceutical value chain. Here, we advance the case for a molecular systems approach to crossing the preclinical-to-clinical translational chasm and for metabolomic analysis of readily accessible bodyfluids as a key technology in translational activities.:
authors: TNO Systems Biology, Netherlands Organization for Applied Scientific Research, Zeist, Netherlands.
authors: Jan
authors: J
authors: van der Greef
authors: BG Medicine, Inc., Waltham, MA 02451, USA.
authors: Aram
authors: A
authors: Adourian
authors: BG Medicine, Inc., Waltham, MA 02451, USA. Electronic address:PMuntendam@bg-medicine.com.
authors: Pieter
authors: P
authors: Muntendam
authors: BG Medicine, Inc., Waltham, MA 02451, USA.
authors: Robert N
authors: RN
authors: McBurney