title: [Cytogenetical and molecular analyses in a horse with SRY-negative sex reversal].
abstract: Numerical and structural aberrations of chromosomes may cause malformations, embryonal losses and reduced or missing fertility. In male horses the fertility is rather well controlled through their semen evaluation. For mares there are no mandatory regulations which specify their use in a breeding programme. Therefore, mares with chromosomal aberrations, which exclude reproduction success may be chosen for breeding. The present case describes a horse, offically registered as a female, which was presented for a breeding exam. On this occasion, small and inactive ovaries were diagnosed. Although the cytogenetical analysis excluded a numerical or gross structural chromosome aberration, the karyotype (64,XY) corresponded to the male sex. The diagnosis male to female sex-reversal (SRY-negative) excludes reproductive success for this horse. This case underlines the importance of a cytogenetic analysis for female horses, before they enter a breeding programme.
authors: Klinik für Reproduktionsmedizin, Vetsuisse-Fakultät Universität Zürich.
authors: A
authors: A
authors: Pieńkowska-Schelling
authors: Institut für Genetik, Vetsuisse-Fakultät Universität Bern.
authors: D
authors: D
authors: Becker
authors: Tierklinik Leimental, Biel-Benken.
authors: V
authors: V
authors: Bracher
authors: Klinik für Reproduktionsmedizin, Vetsuisse-Fakultät Universität Zürich.
authors: B
authors: B
authors: Pineroli
authors: Klinik für Reproduktionsmedizin, Vetsuisse-Fakultät Universität Zürich.
authors: C
authors: C
authors: Schelling
mesh_terms: D000818:Animals; D020732:Cytogenetic Analysis; D012734:Disorders of Sex Development / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology; D005260:Female; D005298:Fertility; D006736:Horses; D059785:Karyotype; D008297:Male
keywords: Chromosomen; Fruchtbarkeit; Pferd; Sex-Umkehr; chromosomes; fertility; horse; sex-reversal