title: [Cutaneous squamous cell carcinoma: a review with consideration of special patient groups].
abstract: The incidence of non-melanoma skin cancer (NMSC) is increasing. Squamous cell carcinoma of the skin (SCC) is a tumor of the elderly. Due to the increasing life expectancy, SCC will become more and more frequent in the future. Generally SCC has a favorable prognosis. Standard therapy is microscopically- controlled excision. Therapy of advanced and metastatic SCC is still challenging. Patients with regional lymph node metastasis have ten-year survival rates less than 20%; patients with distant metastases less than 10%. Immunosuppression has been shown to be one of the key prognostic factors for metastasis. The article reviews SCC and focusses on patients being at risk for an unfavorable course.
authors: Klinik für Dermatologie, Universitätsklinikum Essen, Westdeutsches Tumorzentrum, Universität Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Deutschland, uwe.hillen@uk-essen.de.
authors: U
authors: U
authors: Hillen
authors: M
authors: M
authors: Ulrich
authors: M
authors: M
authors: Alter
authors: J C
authors: JC
authors: Becker
authors: R
authors: R
authors: Gutzmer
authors: U
authors: U
authors: Leiter
authors: A
authors: A
authors: Lonsdorf
authors: A
authors: A
authors: Messerschmidt
authors: C
authors: C
authors: Ulrich
mesh_terms: D017677:Age Distribution; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D062109:Dermatologic Surgical Procedures / Q000379:methods*; D006801:Humans; D015994:Incidence; D018570:Risk Assessment; D012307:Risk Factors; D017678:Sex Distribution; D012878:Skin Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D015996:Survival Rate
chemical_list: D000970:Antineoplastic Agents