title: Selection of aptamers targeting the sialic acid receptor of hemagglutinin by epitope-specific SELEX.
abstract: A new SELEX scheme is proposed for the selection of aptamers targeting a specific epitope of a native protein. Anti-sialic acid receptor (SAR) aptamers that inhibit H1 hemagglutination at a low picomole dose are selected accordingly.
authors: Department of Bio-Industrial Mechatronics Engineering, National Taiwan University, Taipei 10617, Taiwan. chenlinchi@ntu.edu.tw.
authors: Yeh-Hsing
authors: YH
authors: Lao
authors: Hui-Yu
authors: HY
authors: Chiang
authors: Deng-Kai
authors: DK
authors: Yang
authors: Konan
authors: K
authors: Peck
authors: Lin-Chi
authors: LC
authors: Chen
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology; D052157:Aptamers, Nucleotide / Q000235:genetics*; D004277:DNA, Single-Stranded / Q000737:chemistry; D000939:Epitopes / Q000187:drug effects*; D006384:Hemagglutination / Q000187:drug effects; D006388:Hemagglutinins / Q000187:drug effects*; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects; D011956:Receptors, Cell Surface / Q000187:drug effects*; D052156:SELEX Aptamer Technique; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D052157:Aptamers, Nucleotide; D004277:DNA, Single-Stranded; D000939:Epitopes; D006388:Hemagglutinins; D011956:Receptors, Cell Surface; C092488:sialic acid receptor