title: Bioactive and biodegradable nanocomposites and hybrid biomaterials for bone regeneration.
abstract: Strategies for bone tissue engineering and regeneration rely on bioactive scaffolds to mimic the natural extracellular matrix and act as templates onto which cells attach, multiply, migrate and function. Of particular interest are nanocomposites and organic-inorganic (O/I) hybrid biomaterials based on selective combinations of biodegradable polymers and bioactive inorganic materials. In this paper, we review the current state of bioactive and biodegradable nanocomposite and O/I hybrid biomaterials and their applications in bone regeneration. We focus specifically on nanocomposites based on nano-sized hydroxyapatite (HA) and bioactive glass (BG) fillers in combination with biodegradable polyesters and their hybrid counterparts. Topics include 3D scaffold design, materials that are widely used in bone regeneration, and recent trends in next generation biomaterials. We conclude with a perspective on the future application of nanocomposites and O/I hybrid biomaterials for regeneration of bone.
authors: Department of Chemical and Biochemical Engineering, The University of Western Ontario, London, Ontario N6A 5B9, Canada. ballo@uwo.ca.
authors: Bedilu A
authors: BA
authors: Allo
authors: Department of Chemical and Biochemical Engineering, The University of Western Ontario, London, Ontario N6A 5B9, Canada. dcosta@uwo.ca.
authors: Daniel O
authors: DO
authors: Costa
authors: Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, Ontario N6A 5C1, Canada. jeff.dixon@schulich.uwo.ca.
authors: S Jeffrey
authors: SJ
authors: Dixon
authors: Department of Chemical and Biochemical Engineering, The University of Western Ontario, London, Ontario N6A 5B9, Canada. kmequani@uwo.ca.
authors: Kibret
authors: K
authors: Mequanint
authors: Department of Chemical and Biochemical Engineering, The University of Western Ontario, London, Ontario N6A 5B9, Canada. arizkall@uwo.ca.
authors: Amin S
authors: AS
authors: Rizkalla