title: Novel biomarkers in heart failure with preserved ejection fraction.
abstract: Heart failure with preserved ejection fraction (HFPEF) is a common subtype of heart failure with morbidity and mortality similar to that of heart failure with systolic dysfunction. This article discusses the numerous biomarkers that promise to play a substantial role in terms of our ability to understand the mechanisms of HFPEF and discern possible phenotypes that respond to targeted therapies: natriuretic peptides, high-sensitivity troponins, galectin-3, soluble ST2, neutrophil gelatinase-associated lipocalin, and cystatin C.
authors: Department of Internal Medicine, University of California, San Diego, 402 Dickinson Street, Suite 380, San Diego, CA 92103-8425, USA.
authors: Kevin S
authors: KS
authors: Shah
authors: Cardiology Section (9111-A), VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA. Electronic address: amaisel@ucsd.edu.
authors: Alan S
authors: AS
authors: Maisel
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood*; D055316:Cystatin C / Q000097:blood; D018450:Disease Progression; D005260:Female; D037502:Galectin 3 / Q000097:blood; D006333:Heart Failure / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D000072179:Interleukin-1 Receptor-Like 1 Protein; D008297:Male; D008875:Middle Aged; D045265:Natriuretic Peptides / Q000097:blood*; D011379:Prognosis; D011956:Receptors, Cell Surface / Q000097:blood; D012016:Reference Values; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D013318:Stroke Volume / Q000502:physiology*; D013577:Syndrome; D020107:Troponin T / Q000097:blood
chemical_list: D015415:Biomarkers; D055316:Cystatin C; D037502:Galectin 3; C079241:IL1RL1 protein, human; D000072179:Interleukin-1 Receptor-Like 1 Protein; D045265:Natriuretic Peptides; D011956:Receptors, Cell Surface; D020107:Troponin T
keywords: Biomarkers; Diagnosis; Heart failure; Preserved ejection fraction; Prognosis