title: Functional genomics and target gene validation in experimental and human disease.
abstract: In contrast to rare monogenic disorders related to mutations in distinct genes, frequent multifactorial diseases including complex neuronal disorders as well as neoplasms involve expression changes in a multitude of genes. The integration of data derived from human disease tissue and of animal models by data mining constitutes a recent approach to increase the pathogenetic significance of target genes. Functional validation by animal models represents a key step to develop new treatment pathways for common disorders.:
authors: University Children's Hospital of Essen, Hufelandstr. 55, 45122 Essen, Germany.
authors: Johannes H
authors: JH
authors: Schulte
authors: Department of Neuropathology, University of Bonn Medical Center, Sigmund-Freud Str. 25, 53105 Bonn, Germany.
authors: Julika
authors: J
authors: Pitsch
authors: Department of Neuropathology, University of Bonn Medical Center, Sigmund-Freud Str. 25, 53105 Bonn, Germany. Electronic address:albert_becker@uni-bonn.de.
authors: Albert J
authors: AJ
authors: Becker