title: Use of dietary phytochemicals to target inflammation, fibrosis, proliferation, and angiogenesis in uterine tissues: promising options for prevention and treatment of uterine fibroids?
abstract: Uterine leiomyomas (fibroids, myomas) are the most common benign tumors of female reproductive tract. They are highly prevalent, with 70-80% of women burdened by the end of their reproductive years. Fibroids are a leading cause of pelvic pain, abnormal vaginal bleeding, pressure on the bladder, miscarriage, and infertility. They are the leading indication for hysterectomy, and costs exceed 6 billion dollars annually in the United States. Unfortunately, no long-term medical treatments are available. Dysregulation of inflammatory processes are thought to be involved in the initiation of leiomyoma and extracellular matrix deposition, cell proliferation, and angiogenesis are the key cellular events implicated in leiomyoma growth. In modern pharmaceutical industries, dietary phytochemicals are used as source of new potential drugs for many kinds of tumors. Dietary phytochemicals may exert therapeutic effects by interfering with key cellular events of the tumorigenesis process. At present, a negligible number of phytochemicals have been tested as therapeutic agents against fibroids. In this context, our aim was to introduce some of the potential dietary phytochemicals that have shown anti-inflammatory, antiproliferative, antifibrotic, and antiangiogenic activities in different biological systems. This review could be useful to stimulate the evaluation of these phytochemicals as possible therapies for uterine fibroids.
authors: Department of Experimental and Clinical Medicine, Faculty of Medicine, Polytechnic University of Marche, Ancona, Italy; Biotechnology and Microbiology Laboratory, Department of Botany, University of Rajshahi, Rajshahi, Bangladesh.
authors: Md Soriful
authors: MS
authors: Islam
authors: Most Mauluda
authors: MM
authors: Akhtar
authors: Andrea
authors: A
authors: Ciavattini
authors: Stefano Raffaele
authors: SR
authors: Giannubilo
authors: Olga
authors: O
authors: Protic
authors: Milijana
authors: M
authors: Janjusevic
authors: Antonio Domenico
authors: AD
authors: Procopio
authors: James H
authors: JH
authors: Segars
authors: Mario
authors: M
authors: Castellucci
authors: Pasquapina
authors: P
authors: Ciarmela
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D049109:Cell Proliferation; D019587:Dietary Supplements; D005260:Female; D005355:Fibrosis; D006801:Humans; D007889:Leiomyoma / Q000178:diet therapy / Q000276:immunology / Q000503:physiopathology / Q000517:prevention & control*; D009389:Neovascularization, Pathologic / Q000209:etiology / Q000517:prevention & control; D018919:Neovascularization, Physiologic; D064209:Phytochemicals / Q000627:therapeutic use*; D014599:Uterus / Q000098:blood supply / Q000166:cytology / Q000276:immunology* / Q000473:pathology
chemical_list: D020533:Angiogenesis Inhibitors; D000894:Anti-Inflammatory Agents, Non-Steroidal; D064209:Phytochemicals
keywords: Antifibrotic; Antiproliferative; Dietary phytochemicals; Inflammation; Uterine fibroid