title: Clinicopathological characteristics and prognostic factors of primary gastrointestinal lymphoma: a 22-year experience from South China.
abstract: Primary gastrointestinal lymphoma (PGIL) is a kind of relatively rare cancer and easily misdiagnosed due to its unspecific signs in digestive tract. Data including 216 patients histologically diagnosed as PGIL between January 1991 and October 2012 from The First Affiliated Hospital of Sun Yat-sen University were reviewed. This study was to investigate the clinicopathological features and prognosis, and make the comparison between the different sites of PGIL. Abdominal pain (75.9%) was the most frequent symptom and intermediate-grade lymphoma (53.7%) presented as the most common histological type. Intestine (55.1%) was the most common site involved, followed by stomach (38.5%), both intestine and stomach (6.4%). PGIL of different original site showed distinguished clinicopathological characteristics that patients in Stomach and GI group were older than Intestine group (Mean age: 54 and 53 vs. 43 years, p<0.001); diarrhea, B symptom, abdominal mass and complication occurred more in intestine group. Histologically, high-grade lymphoma (especially T-cell type) almost located in Intestine group (82.5%). Five-year overall survival (OS) and event-free survival (EFS) for all PGIL patients were 56.4% and 49.3%, respectively. Stomach group had better OS (72.3%) and EFS (48.4%) than Intestine group (43.1% and 23.6% respectively), but it lost the significance in the multivariate analysis. Univariate and multivariate analysis revealed that performance status, lactate dehydrogenase (LDH) level and histological type were independent prognostic factors for PGIL.
authors: Division of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University Guangzhou 510080, P.R. China.
authors: Minrui
authors: M
authors: Li
authors: Division of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University Guangzhou 510080, P.R. China.
authors: Shenghong
authors: S
authors: Zhang
authors: Division of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University Guangzhou 510080, P.R. China.
authors: Fang
authors: F
authors: Gu
authors: Division of Radiation Oncology, Cancer Center of Sun Yat-sen University Guangzhou 510080, P.R. China ; State Key Laboratory of Oncology in South China Guangzhou 510080, P.R. China.
authors: Weiwei
authors: W
authors: Xiao
authors: Division of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University Guangzhou 510080, P.R. China.
authors: Jiayan
authors: J
authors: Yao
authors: Division of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University Guangzhou 510080, P.R. China.
authors: Kang
authors: K
authors: Chao
authors: Division of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University Guangzhou 510080, P.R. China.
authors: Minhu
authors: M
authors: Chen
authors: Division of Hematology, The First Affiliated Hospital, Sun Yat-sen University Guangzhou 510080, P.R. China.
authors: Juan
authors: J
authors: Li
authors: Division of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University Guangzhou 510080, P.R. China.
authors: Bihui
authors: B
authors: Zhong
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D002681:China; D018572:Disease-Free Survival; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000150:complications / Q000201:enzymology / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D006785:Hospitals, University; D006801:Humans; D053208:Kaplan-Meier Estimate; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D008223:Lymphoma / Q000150:complications / Q000201:enzymology / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D060787:Neoplasm Grading; D016016:Proportional Hazards Models; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D007770:L-Lactate Dehydrogenase
keywords: Primary gastrointestinal lymphoma; chemotherapy; clinicopathological characteristics; performance status; prognostic factors