title: HP-1γ Controls High-Affinity Antibody Response to T-Dependent Antigens.
abstract: In vitro observations suggest a role for the mouse heterochromatin protein 1γ (HP-1γ) in the immune system. However, it has not been shown if and how HP-1γ contributes to immunity in vivo. Here we show that in mice, HP-1γ positively regulates the germinal center reaction and high-affinity antibody response to thymus (T)-dependent antigens by limiting the size of CD8(+) regulatory T-cell (Treg) compartment without affecting progenitor B- or T-cell-development. Moreover, HP-1γ does not control cell proliferation or class switch recombination. Haploinsufficiency of cbx-3 (gene encoding HP-1γ) is sufficient to expand the CD8(+) Treg population and impair the immune response in mice despite the presence of wild-type HP-1α and HP-1β. This is the first in vivo evidence demonstrating the non-redundant role of HP-1γ in immunity.
authors: Beth Israel Deaconess Medical Center, Department of Pathology, Harvard Medical School , Boston, MA , USA.
authors: Ngoc
authors: N
authors: Ha
authors: Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven , Leuven , Belgium.
authors: Duc-Hung
authors: DH
authors: Pham
authors: Department of Pathology, Brigham and Women's Hospital , Boston, MA , USA.
authors: Aliakbar
authors: A
authors: Shahsafaei
authors: Advanced Science Research Center, Kanazawa University , Kanazawa , Japan.
authors: Chie
authors: C
authors: Naruse
authors: Advanced Science Research Center, Kanazawa University , Kanazawa , Japan.
authors: Masahide
authors: M
authors: Asano
authors: Beth Israel Deaconess Medical Center, Department of Pathology, Harvard Medical School , Boston, MA , USA.
authors: To-Ha
authors: TH
authors: Thai
keywords: CD8+ regulatory T cells; adaptive immunity; chromatin remodeling; epigenetics; germinal center response