title: Do statins have a role in the promotion of postoperative wound healing in cardiac surgical patients?
abstract: Cardiac surgical patients often have associated comorbidities that can impede normal wound healing; however, statin therapy has the potential to improve this process through augmentation of the normal inflammatory response. Outcomes included a 30% earlier rate of wound epithelialization and an 80% greater wound-breaking strength combined with faster wound healing rates (13.0 days vs 18.7 days, p<0.0001). Inhibition of farnesyl pyrophosphate may hold a key role in the mediation of such advantageous effects. This systematic review suggests that there is sufficient evidence to warrant completion of a human trial to assess the effects of statins on wound healing.
authors: Department of Cardiothoracic Surgery, Our Lady's Children's Hospital, Crumlin, Dublin, Ireland; Department of Anaesthetics, Intensive Care & Pain Medicine, School of Medicine, Cardiff University, Cardiff, Wales. Electronic address: gfitzmaurice@doctors.org.uk.
authors: Gerard J
authors: GJ
authors: Fitzmaurice
authors: Department of Anaesthetics, Intensive Care & Pain Medicine, School of Medicine, Cardiff University, Cardiff, Wales.
authors: Billy
authors: B
authors: McWilliams
authors: Department of Cardiothoracic Surgery, Our Lady's Children's Hospital, Crumlin, Dublin, Ireland.
authors: Lars
authors: L
authors: Nölke
authors: Department of Cardiothoracic Surgery, Our Lady's Children's Hospital, Crumlin, Dublin, Ireland.
authors: J Mark
authors: JM
authors: Redmond
authors: Department of Cardiothoracic Surgery, Our Lady's Children's Hospital, Crumlin, Dublin, Ireland.
authors: Jonathan G
authors: JG
authors: McGuinness
authors: Sports and Exercise Sciences Research Institute, Faculty of Life and Health Sciences, University of Ulster, Ulster, Ireland; Division of Vascular and Endovascular Surgery, Mayo Clinic, Phoenix, Arizona.
authors: Mark E
authors: ME
authors: O'Donnell
mesh_terms: D006348:Cardiac Surgical Procedures; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors