title: Design of symmetrical and nonsymmetricalN,N-dimethylaminopyridine derivatives as highly potent choline kinase alpha inhibitors.
abstract: Choline kinase alpha is hyperactivated in many solid tumours and regulates malignant progression, making it a promising cancer drug target. The successful design and synthesis of novel inhibitors with high cellular activity are described.
authors: Comprehensive Cancer Imaging Centre, Department of Surgery & Cancer, Hammersmith Campus, Imperial College, London, UK.
authors: Sebastian
authors: S
authors: Trousil
authors: Comprehensive Cancer Imaging Centre, Department of Surgery & Cancer, Hammersmith Campus, Imperial College, London, UK.
authors: Laurence
authors: L
authors: Carroll
authors: Comprehensive Cancer Imaging Centre, Department of Surgery & Cancer, Hammersmith Campus, Imperial College, London, UK.
authors: Andrew
authors: A
authors: Kalusa
authors: Comprehensive Cancer Imaging Centre, Department of Surgery & Cancer, Hammersmith Campus, Imperial College, London, UK.
authors: Ola
authors: O
authors: Aberg
authors: Comprehensive Cancer Imaging Centre, Department of Surgery & Cancer, Hammersmith Campus, Imperial College, London, UK.
authors: Maciej
authors: M
authors: Kaliszczak
authors: Comprehensive Cancer Imaging Centre, Department of Surgery & Cancer, Hammersmith Campus, Imperial College, London, UK.
authors: Eric O
authors: EO
authors: Aboagye