title: Calcium and magnesium disorders.
abstract: Hypocalcemia is a clinical disorder that can be life threatening to the cow (milk fever) and predisposes the animal to various other metabolic and infectious disorders. Calcium homeostasis is mediated primarily by parathyroid hormone, which stimulates bone calcium resorption and renal calcium reabsorption. Parathyroid hormone stimulates the production of 1,25-dihydroxyvitamin D to enhance diet calcium absorption. High dietary cation-anion difference interferes with tissue sensitivity to parathyroid hormone. Hypomagnesemia reduces tissue response to parathyroid hormone.
authors: Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, 2048 Vet Med, Ames, IA 50011, USA. Electronic address: jpgoff@iastate.edu.
authors: Jesse P
authors: JP
authors: Goff
mesh_terms: D000818:Animals; D002118:Calcium / Q000097:blood / Q000378:metabolism*; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000378:metabolism*; D005260:Female; D006996:Hypocalcemia / Q000378:metabolism / Q000662:veterinary*; D008274:Magnesium / Q000097:blood / Q000378:metabolism*
chemical_list: D008274:Magnesium; D002118:Calcium
keywords: DCAD; Hypocalcemia; Hypomagnesemia; Milk fever; Parathyroid hormone