title: Spontaneous remission of a squamous cell carcinoma of the floor of the mouth.
abstract: Spontaneous remission is a rare, but well recognized event in oncology. Certain tumours, such as melanomas, hypernephromas and neuroblastomas, are known for showing spontaneous regression. Similarly, spontaneous regression of oral lymphomas, as well as oropharyngeal and recurrent tongue carcinomas, has been reported. Here, we present a novel case of a patient with a primary squamous cell carcinoma on the floor of the mouth whose tumour regressed spontaneously in three months, without any treatment. We also review of the literature on the spontaneous remission of oral cancer and discuss possible mechanisms for this phenomenon.
authors: Instituto Alfa de Gastroenterologia, Federal University of Minas Gerais, Brazil.
authors: Alexandre
authors: A
authors: de Andrade Sousa
authors: Instituto Alfa de Gastroenterologia, Federal University of Minas Gerais, Brazil.
authors: Rafael
authors: R
authors: Lopes Rena
authors: Instituto Alfa de Gastroenterologia, Federal University of Minas Gerais, Brazil.
authors: Guilherme
authors: G
authors: Souza Silva
authors: Instituto Alfa de Gastroenterologia, Federal University of Minas Gerais, Brazil; School of Medicine, Federal University of Sao Joao Del Rey, Brazil.
authors: João
authors: J
authors: Marcos Arantes Soares
authors: Instituto Alfa de Gastroenterologia, Federal University of Minas Gerais, Brazil.
authors: José Maria
authors: JM
authors: Porcaro-Salles
authors: School of Dentistry, Federal University of Minas Gerais, Brazil.
authors: Laiz
authors: L
authors: Nunes
authors: School of Dentistry, Federal University of Minas Gerais, Brazil.
authors: Ricardo
authors: R
authors: Alves Mesquita
authors: College of Dental Medicine - Illinois, Midwestern University, 555 31st Street, Science Hall 211-II, Downers Grove, IL 60515, USA. Electronic address: bjham@midwestern.edu.
authors: Bruno Correia
authors: BC
authors: Jham
mesh_terms: D001706:Biopsy / Q000379:methods; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009060:Mouth Floor / Q000473:pathology*; D009061:Mouth Mucosa / Q000473:pathology; D009062:Mouth Neoplasms / Q000473:pathology*; D009365:Neoplasm Regression, Spontaneous / Q000473:pathology*; D019226:Oral Ulcer / Q000473:pathology
keywords: Floor of the mouth; Oral cancer; Primary; Spontaneous regression; Spontaneous remission; Squamous cell carcinoma