title: Therapeutic interventions in sepsis: current and anticipated pharmacological agents.
abstract: Sepsis is a clinical syndrome characterized by a multisystem response to a pathogenic assault due to underlying infection that involves a combination of interconnected biochemical, cellular and organ-organ interactive networks. After the withdrawal of recombinant human-activated protein C (rAPC), researchers and physicians have continued to search for new therapeutic approaches and targets against sepsis, effective in both hypo- and hyperinflammatory states. Currently, statins are being evaluated as a viable option in clinical trials. Many agents that have shown favourable results in experimental sepsis are not clinically effective or have not been clinically evaluated. Apart from developing new therapeutic molecules, there is great scope for for developing a variety of drug delivery strategies, such as nanoparticulate carriers and phospholipid-based systems. These nanoparticulate carriers neutralize intracorporeal LPS as well as deliver therapeutic agents to targeted tissues and subcellular locations. Here, we review and critically discuss the present status and new experimental and clinical approaches for therapeutic intervention in sepsis.
authors: Pharmaceutics Division, Preclinical South PCS 002/011, CSIR - Central Drug Research Institute, Lucknow, India.
authors: Prashant
authors: P
authors: Shukla
authors: G Madhava
authors: GM
authors: Rao
authors: Gitu
authors: G
authors: Pandey
authors: Shweta
authors: S
authors: Sharma
authors: Naresh
authors: N
authors: Mittapelly
authors: Ranjita
authors: R
authors: Shegokar
authors: Prabhat Ranjan
authors: PR
authors: Mishra
mesh_terms: D000818:Animals; D002319:Cardiovascular System / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007668:Kidney / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D008070:Lipopolysaccharides / Q000378:metabolism; D008099:Liver / Q000276:immunology / Q000503:physiopathology; D008168:Lung / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D018805:Sepsis / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology
chemical_list: D008070:Lipopolysaccharides