title: A unique perylene-based DNA intercalator: localization in cell nuclei and inhibition of cancer cells and tumors.
abstract: To date, perylene derivatives have not been explored as DNA intercalator to inhibit cancer cells by intercalating into the base pairs of DNA. Herein, a water-soluble perylene bisimide (PBDI) that efficiently intercalates into the base pairs of DNA is synthesized. Excitingly, PBDI is superior to the commercial DNA intercalator, amonafide, for specific nuclear accumulation and effective suppression of cancer cells and tumors.
authors: State Key Laboratory of Chemical Resource Engineering, Key Laboratory of Carbon Fiber and Functional Polymers, Ministry of Education Beijing, University of Chemical Technology, 100029, Beijing, China.
authors: Zejun
authors: Z
authors: Xu
authors: Kunru
authors: K
authors: Guo
authors: Jieshi
authors: J
authors: Yu
authors: Haili
authors: H
authors: Sun
authors: Jun
authors: J
authors: Tang
authors: Jie
authors: J
authors: Shen
authors: Klaus
authors: K
authors: Müllen
authors: Wantai
authors: W
authors: Yang
authors: Meizhen
authors: M
authors: Yin
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002467:Cell Nucleus / Q000378:metabolism*; D002478:Cells, Cultured; D002942:Circular Dichroism; D004247:DNA / Q000378:metabolism*; D006801:Humans; D007364:Intercalating Agents / Q000378:metabolism*; D015394:Molecular Structure; D010569:Perylene / Q000737:chemistry / Q000378:metabolism*; D013050:Spectrometry, Fluorescence
chemical_list: D007364:Intercalating Agents; D010569:Perylene; D004247:DNA
keywords: DNA intercalator; anticancer activity; nuclear accumulation; perylene bisimides; planar nanoscaffolds