title: How has urinary proteomics contributed to the discovery of early biomarkers of acute kidney injury?
abstract: In the past decade, analysis of the urinary proteome (urinary proteomics) has intensified in response to the need for novel biomarkers that support early diagnosis of kidney diseases. In particular, this also applies to acute kidney injury, which is a heterogeneous complex syndrome with a still-increasing incidence at the intensive care unit. Unfortunately, this major need remains largely unmet to date. The current report aims to explain why attempts to implement urinary proteomic-discovered acute kidney injury diagnostic candidates in the intensive care unit setting have not yet led to success. Subsequently, some key notes are provided that should enhance the chance of translating selected urinary proteomic candidates to valuable tools for the nephrologist and intensivist in the near future.
authors: Ghent University, Department of Pharmacology, Toxicology and Biochemistry, B-9820 Merelbeke, Belgium.
authors: Jorien
authors: J
authors: De Loor
authors: Kris
authors: K
authors: Gevaert
authors: Eric
authors: E
authors: Hoste
authors: Evelyne
authors: E
authors: Meyer
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000209:etiology / Q000652:urine; D000818:Animals; D015415:Biomarkers / Q000652:urine; D006348:Cardiac Surgical Procedures / Q000009:adverse effects; D006801:Humans; D008297:Male; D040901:Proteomics / Q000379:methods*; D018805:Sepsis / Q000150:complications; D014556:Urine / Q000737:chemistry*
chemical_list: D015415:Biomarkers
keywords: acute kidney injury; animal model; diagnostic biomarker; early detection; intensive care unit; urinary proteomics