title: Seroprevalence of helicobacter pylori in human immunodeficiency virus-positive Patients and it's correlation with CD4(+) Lymphocyte Count.
abstract: BACKGROUND
  This study assessed the seroprevalence of Helicobacter pylori antibodies among Iranian patients with human immunodeficiency virus (HIV) infection. It also examines whether anti H. pylori seroprevalence was associated with the severity of the HIV infection or the antiretroviral treatment.
  
  
  METHODS
  A total of 114 HIV-infected patients and 114 age and sex-matched controls, without symptoms referable to upper gastrointestinal tract were recruited. Blood samples were obtained from all subjects. Serum IgG and IgA against H. pylori measured using the enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  The rate of anti H. pylori IgG seropositivity was 57.9% in HIV-infected patients and 28.95% in controls (P < 0.001), while the rate of IgA seropositivity was 2.64% in HIV patients and 31.57% in controls (P < 0.001). Although there was an increasing trend of higher IgG and IgA titre by increasing CD4 cell count in HIV-positive patients, it was not reach statistical significance. There was no statistical difference in the serology of anti H. pylori IgG and IgA between patients receiving antiretroviral therapy comparing untreated HIV patients.
  
  
  CONCLUSIONS
  This study showed higher seroprevalence of H. pylori IgG along with lower seroprevalence of H. pylori IgA in HIV-positive patients compared matched controls.
authors: Associate Professor of Pathology, Central Laboratory, Tehran University of Medical Sciences, Tehran, Iran.
authors: Alireza
authors: A
authors: Abdollahi
authors: Associate Professor of Pathology, Central Laboratory, Tehran University of Medical Sciences, Tehran, Iran ; Laboratory Assistant, Student Scientific Research Center, Central Laboratory, Tehran University of Medical Sciences, Tehran, Iran.
authors: Saeed
authors: S
authors: Shoar
authors: Associate Professor of Infectious Diseases, Infectious Diseases Department, Imam Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
authors: Siroos
authors: S
authors: Jafari
authors: Associate Professor of Infectious Diseases, Infectious Diseases Department, Imam Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
authors: Hamid
authors: H
authors: Emadi-Kochak
keywords: H. pylori; HIV; IgA; IgG; Seroprevalence