title: Impact of neonatal factors and nutrition on kidney size in 5-year-old preterm-born children.
abstract: OBJECTIVE
  The aim of this article is to evaluate the influence of neonatal factors on kidney size in 5-year-old preterm-born children.
  
  
  METHODS
  Preterm-born children were examined at 5 years with kidney ultrasound.
  
  
  RESULTS
  A total of 20 children were evaluated. Their gestational age (GA) was 29.3 ± 1.5 weeks, birth weight 1,321 ± 323 g. On Day 28, protein intake was (median, range) 2.8 (1.7-3.6 g/kg) g/kg, protein/total calories ratio 2.8 (range, 1.7-3.3 g/100 kcal) g/100 kcal. At 5 years, their systolic blood pressure was 97 mm Hg (range, 84-115 mm Hg). All had normal estimated glomerular filtration rate. Protein intake on Day 28 and protein/calories ratio on Day 28 were associated with a low total relative renal volume, respectively, β =  - 37 ± 15, p = 0.03; β =  - 50 ± 19, p = 0.03, after adjustment on GA, neonatal morbidities, and body mass index (multivariate linear regression). Kidney size was not associated with protein intake at 5 years.
  
  
  CONCLUSIONS
  Improving protein prescription in the neonatal period could have an impact on kidney size in childhood in preterm-born children.
authors: Neonatal Department, Maternite Regionale Universitaire, Nancy, France.
authors: Sorana C
authors: SC
authors: Galu
authors: Neonatal Department, Maternite Regionale Universitaire, Nancy, France.
authors: Jean-Michel
authors: JM
authors: Hascoet
authors: Neonatal Department, Maternite Regionale Universitaire, Nancy, France.
authors: Rachel
authors: R
authors: Vieux
mesh_terms: D001724:Birth Weight / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D002675:Child, Preschool; D005260:Female; D005865:Gestational Age; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D007668:Kidney / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D015999:Multivariate Analysis; D009752:Nutritional Status / Q000502:physiology*; D009929:Organ Size; D011446:Prospective Studies; D014463:Ultrasonography