title: Vagus nerve stimulator implantation for epilepsy in a paediatric hospital: outcomes and effect on quality of life.
abstract: BACKGROUND
  Epilepsy, which is present in 0.5% to 1% of the paediatric population, is one of the most frequent childhood neurological disorders. Approximately 20% to 30% of these cases will be drug-resistant. The objective of this study is to describe the impact of vagal nerve stimulation (VNS) on seizures and quality of life in a sample of 30 patients.
  
  
  METHODS
  Descriptive, retrospective study of all patients with a VNS device implanted between 2008 and 2013 in a single paediatric hospital, based on patients' medical records. Quality of life was assessed using the Spanish scale for quality of life in children with epilepsy, completed by means of a telephone interview.
  
  
  RESULTS
  We describe a population of 19 boys (64%) and 11 girls (36%) with a mean age at seizure onset of 21 months (1-144 months). The mean age of VNS implantation was 11.89 years. Follow-up periods ranged from 6 to 36 months. Mean reduction in seizures at 6 months was 38%, with a reduction of 43% at 12 months, 42% at 24 months, and 54% at 36 months. At least half of all patients were classified as responders. According to the quality of life scale, 54% of the families rated the effect of VNS as either very good or good while 39% rated it as fair.
  
  
  CONCLUSIONS
  VNS is a safe palliative treatment that is generally well tolerated. It is partially effective for controlling drug-resistant epilepsy and exerts a positive effect on quality of life.
authors: Unidad de Epilepsia, Servicio de Neurología y Neurocirugía, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, España. Electronic address: adrianaulate@hotmail.com.
authors: A
authors: A
authors: Ulate-Campos
authors: Unidad de Epilepsia, Servicio de Neurología y Neurocirugía, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, España.
authors: L
authors: L
authors: Cean-Cabrera
authors: Unidad de Epilepsia, Servicio de Neurología y Neurocirugía, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, España.
authors: J
authors: J
authors: Petanas-Argemi
authors: Unidad de Epilepsia, Servicio de Neurología y Neurocirugía, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, España.
authors: G
authors: G
authors: García-Fructuoso
authors: Unidad de Epilepsia, Servicio de Neurología y Neurocirugía, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, España.
authors: J
authors: J
authors: Aparicio
authors: Unidad de Epilepsia, Servicio de Neurología y Neurocirugía, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, España.
authors: A
authors: A
authors: López-Sala
authors: Unidad de Epilepsia, Servicio de Neurología y Neurocirugía, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, España.
authors: A
authors: A
authors: Palacio-Navarro
authors: Unidad de Epilepsia, Servicio de Neurología y Neurocirugía, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, España.
authors: M J
authors: MJ
authors: Mas
authors: Unidad de Epilepsia, Servicio de Neurología y Neurocirugía, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, España.
authors: J
authors: J
authors: Muchart
authors: Unidad de Epilepsia, Servicio de Neurología y Neurocirugía, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, España.
authors: M
authors: M
authors: Rebollo
authors: Unidad de Epilepsia, Servicio de Neurología y Neurocirugía, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, España.
authors: F X
authors: FX
authors: Sanmartí
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D000069279:Drug Resistant Epilepsy / Q000628:therapy*; D005260:Female; D006776:Hospitals, Pediatric; D006801:Humans; D008297:Male; D011788:Quality of Life; D012189:Retrospective Studies; D012640:Seizures / Q000209:etiology; D016896:Treatment Outcome; D055536:Vagus Nerve Stimulation / Q000295:instrumentation*; D055815:Young Adult
keywords: Drug-resistant epilepsy; Epilepsia refractaria; Epilepsy treatment; Escala de calidad de vida en el niño con epilepsia; Estimulador nervio vago; Quality of life in children with epilepsy scale; Tratamiento de epilepsia refractaria; Vagal nerve stimulator