title: Examination of daytime sleepiness and cognitive performance testing in patients with primary insomnia.
abstract: OBJECTIVE
  While individuals with insomnia consistently complain of cognitive impairment, previous studies on the effect of insomnia on objective measures of cognitive function have obtained ambiguous results. The relationship between daytime sleepiness and cognitive manifestations in insomnia patients is not clear.
  
  
  METHODS
  Thirty-six primary insomnia patients (PIPs) and 26 good sleep controls (GSCs) with age and gender matched manner were included in the study. Participants underwent an overnight polysomnography followed by a multiple sleep latency test (MSLT) and an examination of the attention network test (ANT). ANT reflected three attentional networks including alerting, orienting and executive control. According to whether accompanied with excessive daytime sleepiness (EDS), the insomnia group were subdivided into PIPs with EDS (n = 12, score on MSLT<10 min) and PIPs without EDS (n = 24, score on MSLT≥10 min).
  
  
  RESULTS
  PIPs only performed worse on executive control function than GSCs in ANT. PIPs with EDS had longer overall reaction time (RT) related to PIPs without EDS. Further analyses with Pearson correlation analysis showed a significant negative correlation between the overall RT and MSLT latency in insomniacs (r = -0.444, p<0.01), whereas no such correlation was found in controls.
  
  
  CONCLUSIONS
  Results suggest that PIPs do show executive control function deficits compared with GSCs. Daytime sleepiness in terms of MSLT latency was associated with poor cognitive manifestations in patients with insomnia.
authors: Sleep Medicine Center, Mental Health Center, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China; Department of Internal Medicine, First People's Hospital of Yibin, Yibin, Sichuan Province, China.
authors: Hong
authors: H
authors: Liu
authors: Sleep Medicine Center, Mental Health Center, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China; Department of Neurosurgery, First People's Hospital of Yibin, Yibin, Sichuan Province, China.
authors: Dexi
authors: D
authors: Wang
authors: Sleep Medicine Center, Mental Health Center, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors: Yun
authors: Y
authors: Li
authors: Sleep Medicine Center, Mental Health Center, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors: Zhe
authors: Z
authors: Li
authors: Department of Psychology, Dalhousie University, Halifax, Nova Scotia, Canada.
authors: Ying
authors: Y
authors: Zhang
authors: Sleep Medicine Center, Mental Health Center, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors: Fei
authors: F
authors: Lei
authors: Sleep Medicine Center, Mental Health Center, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors: Lina
authors: L
authors: Du
authors: Sleep Medicine Center, Mental Health Center, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors: Xiangdong
authors: X
authors: Tang
mesh_terms: D000328:Adult; D001288:Attention; D003071:Cognition; D006970:Disorders of Excessive Somnolence / Q000503:physiopathology*; D056344:Executive Function; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D011930:Reaction Time; D007319:Sleep Initiation and Maintenance Disorders / Q000503:physiopathology*