title: Cyanogramide with a new spiro[indolinone-pyrroloimidazole] skeleton from Actinoalloteichus cyanogriseus.
abstract: Cyanogramide (1), an unprecedented alkaloid bearing a novel spirocyclic pyrrolo[1,2-c]imidazole skeleton, was identified from the fermentation broth of the marine-derived Actinoalloteichus cyanogriseus WH1-2216-6. The structure was fully determined by spectroscopic analysis, an exciton chirality CD method, and quantum mechanical calculations. Cyanogramide (1) could efficiently reverse the adriamycin-induced resistance of K562/A02 and MCF-7/Adr cells, and the vincristine-induced resistance of KB/VCR cells at a concentration of 5 μM, with the reversal fold values of 15.5, 41.5, and 9.7, respectively.
authors: Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, China.
authors: Peng
authors: P
authors: Fu
authors: Fandong
authors: F
authors: Kong
authors: Xia
authors: X
authors: Li
authors: Yi
authors: Y
authors: Wang
authors: Weiming
authors: W
authors: Zhu
mesh_terms: D039903:Actinobacteria / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020014:K562 Cells; D007624:KB Cells; D008386:Marine Biology; D019906:Nuclear Magnetic Resonance, Biomolecular; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D026121:Indole Alkaloids; D013141:Spiro Compounds; C000596830:cyanogramide