title: Assessment of early response to concurrent chemoradiotherapy in cervical cancer: value of diffusion-weighted and dynamic contrast-enhanced MR imaging.
abstract: OBJECTIVE
  To investigate diffusion-weighted (DWI) and dynamic contrast-enhanced MR imaging (DCE-MRI) as early response predictors in cervical cancer patients who received concurrent chemoradiotherapy (CCRT).
  
  
  METHODS
  Sixteen patients with cervical cancer underwent DWI and DCE-MRI before CCRT (preTx), at 1week (postT1) and 4weeks (postT2) after initiating treatment, and 1month after the end of treatment (postT3). At each point, apparent diffusion coefficient (ADC) and DCE-MRI parameters were measured in tumors and gluteus muscles (GM). Tumor response was correlated with imaging parameters or changes in imaging parameters at each point.
  
  
  RESULTS
  At each point, ADC, K(trans) and Ve in tumors showed significant changes (P<0.05), as compared with those of GM (P>0.05). PostT1 tumor ADCs showed a significant correlation with tumor size response at postT2 (P=0.041), and changes in tumor ADCs at postT1 had a significant correlation with tumor size (P=0.04) and volume response (P=0.003) at postT2. In tumors, preTx K(trans) and Ve showed significant correlations with tumor size at postT3 (P=0.011) and tumor size response at postT2 (P=0.019), respectively.
  
  
  CONCLUSIONS
  DWI and DCE-MRI, as early biomarkers, have the potential to evaluate therapeutic responses to CCRT in cervical cancers.
authors: Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors: Jung Jae
authors: JJ
authors: Park
authors: Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address: chankyokim@skku.edu.
authors: Chan Kyo
authors: CK
authors: Kim
authors: Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Department of of Radiology and Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors: Sung Yoon
authors: SY
authors: Park
authors: MR Clinical Science, Philips Healthcare, Best, Netherlands.
authors: Arjan W
authors: AW
authors: Simonetti
authors: Philips Healthcare Korea, Seoul, Republic of Korea; Graduate school of Biomedical Science and Engineering, Hanyang University, Seoul, Republic of Korea.
authors: EunJu
authors: E
authors: Kim
authors: Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors: Byung Kwan
authors: BK
authors: Park
authors: Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors: Seung Jae
authors: SJ
authors: Huh
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D001918:Brachytherapy / Q000379:methods; D059248:Chemoradiotherapy / Q000379:methods*; D003287:Contrast Media / Q000737:chemistry*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000473:pathology; D015203:Reproducibility of Results; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*
chemical_list: D003287:Contrast Media
keywords: Biomarker; Cervical cancer; Concurrent chemoradiotherapy; Diffusion-weighted MRI; Dynamic contrast-enhanced MRI