title: In vitro activities of nine antifungal drugs and their combinations against Phialophora verrucosa.
abstract: The in vitro activities of nine antifungal drugs and their combinations against 31 clinical and 15 environmental Phialophora verrucosa strains were tested. The MIC90/90% minimum effective concentration (MIC/MEC90) values (μg/ml) across all strains were as follows: for terbinafine, 0.25; for posaconazole, 0.5; for voriconazole, 1; for itraconazole, 2; for amphotericin B, 4; for caspofungin and micafungin, 16; and for fluconazole and flucytosine, 64. The highest synergy was shown by the combination of itraconazole plus caspofungin (with synergy against 100% of the 31 clinical strains), followed by amphotericin B plus flucytosine (45.2%) and itraconazole plus terbinafine or micafungin (25.8% or 12.9%, respectively).
authors: Department of Dermatology and Venereology, Peking University First Hospital, Research Center for Medical Mycology, Peking University, and Beijing Key Laboratory of Molecular Diagnosis of Dermatoses, Beijing, People's Republic of China.
authors: Yali
authors: Y
authors: Li
authors: Department of Dermatology and Venereology, Peking University First Hospital, Research Center for Medical Mycology, Peking University, and Beijing Key Laboratory of Molecular Diagnosis of Dermatoses, Beijing, People's Republic of China.
authors: Zhe
authors: Z
authors: Wan
authors: Department of Dermatology and Venereology, Peking University First Hospital, Research Center for Medical Mycology, Peking University, and Beijing Key Laboratory of Molecular Diagnosis of Dermatoses, Beijing, People's Republic of China mycolab@126.com.
authors: Ruoyu
authors: R
authors: Li
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D002862:Chromoblastomycosis / Q000188:drug therapy; D004338:Drug Combinations; D008826:Microbial Sensitivity Tests; D010676:Phialophora / Q000145:classification / Q000187:drug effects*
chemical_list: D000935:Antifungal Agents; D004338:Drug Combinations