title: Pan myeloid antigen-negative pediatric acute megakaryoblastic leukemia.
abstract: Acute megakaryoblastic leukemia (AMKL) is a relatively common type of acute myeloid leukemia in children. We describe two unusual cases of AMKL that by flow cytometry (FC) lacked expression of any commonly evaluated myeloid antigens. One case presented as a periorbital myeloid sarcoma and clinically was thought to be a solid tumor. In both cases, the leukemic blasts were variably positive for the megakaryocytic marker CD61. Cytogenetics confirmed the presence of the t(1;22) in one case. Cytogenetics and inclusion of megakaryocytic markers in FC panels when evaluating pediatric specimens is critical for appropriate diagnosis for myeloid antigen negative AMKL.
authors: Department of Pathology, Arkansas Children's Hospital and the University of Arkansas for Medical Sciences, Little Rock, Arkansas.
authors: Neslihan
authors: N
authors: Cetin
authors: Robert B
authors: RB
authors: Lorsbach
mesh_terms: D002675:Child, Preschool; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007223:Infant; D007947:Leukemia, Megakaryoblastic, Acute / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D051917:Leukosialin / Q000032:analysis; D008297:Male; D014178:Translocation, Genetic
chemical_list: D051917:Leukosialin; C465014:SPN protein, human
keywords: Down syndrome; acute megakaryoblastic leukemia; acute myeloid leukemia; flow cytometry; myeloid sarcoma; pediatric