title: Sensing viral invasion by RIG-I like receptors.
abstract: Cellular responses to pathogen invasion are crucial for maintaining cell homeostasis and survival. The interferon (IFN) system is one of the most effective cellular responses to viral intrusion in mammals. Viral recognition by innate immune sensors activates the antiviral IFN system. Retinoic acid-inducible gene I (RIG-I) like receptors (RLRs) are DExD/H box RNA helicases that sense viral invasion. RLRs recognize cytoplasmic viral RNAs and trigger antiviral responses, resulting in production of type I IFN and inflammatory cytokines. Unique and common sensing mechanisms among RLRs have been reported. In this review, recent progress in the understanding of antiviral responses by RLRs is summarized and discussed.
authors: Laboratory of Molecular Genetics, Institute for Virus Research, Kyoto University, Kyoto, Japan; Laboratory of Molecular Cell Biology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
authors: Ji-Seung
authors: JS
authors: Yoo
authors: Laboratory of Molecular Genetics, Institute for Virus Research, Kyoto University, Kyoto, Japan; Laboratory of Molecular Cell Biology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
authors: Hiroki
authors: H
authors: Kato
authors: Laboratory of Molecular Genetics, Institute for Virus Research, Kyoto University, Kyoto, Japan; Laboratory of Molecular Cell Biology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan. Electronic address: tfujita@virus.kyoto-u.ac.jp.
authors: Takashi
authors: T
authors: Fujita
mesh_terms: D000818:Animals; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D053487:DEAD-box RNA Helicases / Q000276:immunology / Q000378:metabolism*; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D008322:Mammals; D012367:RNA, Viral / Q000276:immunology / Q000378:metabolism; D011971:Receptors, Immunologic / Q000276:immunology / Q000378:metabolism*; D014780:Viruses / Q000276:immunology*
chemical_list: D016207:Cytokines; D012367:RNA, Viral; D011971:Receptors, Immunologic; D053487:DEAD-box RNA Helicases