title: [Comparison of blood leptin concentration and colonic mucosa leptin expression in colon adenoma patients and healthy control].
abstract: OBJECTIVE
  Obesity increases the risk of colorectal cancer and adenomatous polyp, and one of the underlying mechanisms of this increase is considered to be due to the growth promoting effects of adipokines, such as leptin. In order to investigate this finding, leptin expression in the colonic tissue and blood leptin concentration of the colonic adenoma patients were compared to those of the control group.
  
  
  METHODS
  Colonic adenoma tissues were obtained by polypectomy (n=60). In these patients, normal colonic mucosa at remote areas from the polyp was also obtained and blood samples were collected as well. Age and sex matched control subjects were selected among those who showed normal colonic mucosa in health screening colonoscopy (n=60).
  
  
  RESULTS
  There was no significant difference in serum leptin concentration between the colonic adenoma patients and control subjects. Leptin expression was noted in 43.3% of the colonic adenomas, but only in 6.7% of normal colonic mucosa from the control subjects (p<0.01). There were ten cases of concurrent adenocarcinoma in situ in adenoma patients, eight cases of which expressed leptin (p=0.01). In adenoma group, leptin expression rate was significantly high in larger adenomas and in obese patients (p<0.05). However, there was no statistically significant relationship between leptin expression in colonic mucosa and serum leptin level.
  
  
  CONCLUSIONS
  Leptin expression was more frequently observed in colonic adenomas, especially in larger adenomas associated with adenocarcinoma in situ, but blood leptin level was not related to tissue leptin expression. Leptin expression was more frequently observed in obese patients from the adenoma group. Therefore, leptin may play an important role in colonic tumorigenesis and progression, especially in obese patient.
authors: Department of Internal Medicine, Catholic University of Daegu School of Medicine, 33 Duryugongwon-ro 17-gil, Nam-gu, Daegu 705-718, Korea.
authors: Jang Seok
authors: JS
authors: Oh
authors: Hyun Hee
authors: HH
authors: Kim
authors: Hyun Sik
authors: HS
authors: Hwang
authors: Dae Young
authors: DY
authors: Yun
authors: Byung Seok
authors: BS
authors: Kim
authors: Chang Hyeong
authors: CH
authors: Lee
authors: Jimin
authors: J
authors: Han
authors: Ho Gak
authors: HG
authors: Kim
authors: Jin Tae
authors: JT
authors: Jung
authors: Joong Goo
authors: JG
authors: Kwon
authors: Eun Young
authors: EY
authors: Kim
mesh_terms: D000236:Adenoma / Q000378:metabolism / Q000473:pathology*; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D003110:Colonic Neoplasms / Q000378:metabolism / Q000473:pathology*; D003111:Colonic Polyps / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D020738:Leptin / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism / Q000473:pathology; D016017:Odds Ratio; D055105:Waist Circumference
chemical_list: D020738:Leptin