title: High density lipoproteins and type 2 diabetes: Emerging concepts in their relationship.
abstract: Patients with type 2 diabetes mellitus (T2DM) frequently exhibit macrovascular complications of atherosclerotic cardiovascular (CV) disease. High density lipoproteins (HDL) are protective against atherosclerosis. Low levels of HDL cholesterol (HDL-C) independently contribute to CV risk. Patients with T2DM not only exhibit low HDL-C, but also dysfunctional HDL. Furthermore, low concentration of HDL may increase the risk for the development of T2DM through a decreased β cell survival and secretory function. In this paper, we discuss emerging concepts in the relationship of T2DM with HDL.
authors: Michael S Kostapanos, Moses S Elisaf, Department of Internal Medicine, School of Medicine, University of Ioannina, 45110 Ioannina, Greece.
authors: Michael S
authors: MS
authors: Kostapanos
authors: Michael S Kostapanos, Moses S Elisaf, Department of Internal Medicine, School of Medicine, University of Ioannina, 45110 Ioannina, Greece.
authors: Moses S
authors: MS
authors: Elisaf
keywords: High density lipoproteins; Insulin secretion; Paraoxonase-1; Type 2 diabetes; β cells