title: A one-pot parallel reductive amination of aldehydes with heteroaromatic amines.
abstract: A parallel reductive amination of heteroaromatic amines has been performed using a combination of ZnCl2-TMSOAc (activating agents) and NaBH(OAc)3 (reducing agent). A library of diverse secondary amines was easily prepared on a 50-300 mg scale.
authors: Enamine Ltd. , 23 Matrosova Street, Kyiv 01103, Ukraine.
authors: Andrey V
authors: AV
authors: Bogolubsky
authors: Yurii S
authors: YS
authors: Moroz
authors: Pavel K
authors: PK
authors: Mykhailiuk
authors: Dmitriy M
authors: DM
authors: Panov
authors: Sergey E
authors: SE
authors: Pipko
authors: Anzhelika I
authors: AI
authors: Konovets
authors: Andrey
authors: A
authors: Tolmachev
mesh_terms: D000447:Aldehydes / Q000138:chemical synthesis / Q000737:chemistry*; D000586:Amination; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002712:Chlorides / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis* / Q000737:chemistry; D010084:Oxidation-Reduction; D019163:Reducing Agents / Q000737:chemistry; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry; D017967:Zinc Compounds / Q000737:chemistry
chemical_list: D000447:Aldehydes; D000588:Amines; D002712:Chlorides; D006841:Hydrocarbons, Aromatic; D019163:Reducing Agents; D054852:Small Molecule Libraries; D017967:Zinc Compounds; C016837:zinc chloride