title: Research of electrosurgical ablation with antiadhesive functionalization on thermal and histopathological effects of brain tissues in vivo.
abstract: Thermal injury and tissue sticking are two major concerns in the electrosurgery. In the present study, the effect of lateral thermal injury caused by different electrosurgical electrodes on wound healing was investigated. An electrosurgical unit equipped with untreated (SS) and titanium oxide layer-coated (TiO2-coated) stainless steel needle-type electrodes was used to create lesions on the rat brain tissue. TiO2 layers were produced by radiofrequency plasma and magnetron sputtering in the form of amorphous (TO-SS-1), anatase (TO-SS-2), and rutile (TO-SS-3) phase. Animals were sacrificed for evaluations at 0, 2, 7, and 28 days postoperatively. TO-SS-3 electrodes generated lower levels of sticking tissue, and the thermographs showed that the recorded highest temperature in brain tissue from the TO-SS-3 electrode was significantly lower than in the SS electrode. The total injury area of brain tissue caused by TO-SS-1 and TO-SS-3 electrodes was significantly lower than that caused by SS electrodes at each time point. The results of the present study reveal that the plating of electrodes with a TiO2 film with rutile phases is an efficient method for improving the performance of electrosurgical units and should benefit wound healing.
authors: School of Dentistry, Taipei Medical University, Taipei 110, Taiwan.
authors: Wen-Tien
authors: WT
authors: Hsiao
authors: Department of Dentistry, Cathay General Hospital, Taipei 106, Taiwan ; Department of Dentistry, Cathay General Hospital, Sijhih, Taipei 221, Taiwan ; Research Center for Biomedical Devices and Prototyping Production, Taipei Medical University, Taipei 110, Taiwan.
authors: Chun-Ming
authors: CM
authors: Kung
authors: Department of Pathology, School of Medicine, Taipei Medical University, Taipei 110, Taiwan.
authors: Jan-Show
authors: JS
authors: Chu
authors: Research Center for Biomedical Devices and Prototyping Production, Taipei Medical University, Taipei 110, Taiwan ; Graduate Institute of Biomedical Materials and Tissue Engineering, Taipei Medical University, No. 250, Wu-Hsing Street, Taipei 110, Taiwan ; Department of Dentistry, Taipei Medical University, Shuang Ho Hospital, Taipei 235, Taiwan ; Research Center for Biomedical Implants and Microsurgery Devices, Taipei Medical University, Taipei 110, Taiwan.
authors: Keng-Liang
authors: KL
authors: Ou
authors: School of Dental Technology, Taipei Medical University, No. 250, Wu-Hsing Street, Taipei 110, Taiwan.
authors: Pei-Wen
authors: PW
authors: Peng
mesh_terms: D000268:Adhesiveness; D000818:Animals; D001930:Brain Injuries / Q000209:etiology* / Q000517:prevention & control*; D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D004566:Electrodes / Q000009:adverse effects; D004598:Electrosurgery; D008297:Male; D008422:Materials Testing; D051381:Rats; D017207:Rats, Sprague-Dawley; D014025:Titanium / Q000494:pharmacology*
chemical_list: D020099:Coated Materials, Biocompatible; C009495:titanium dioxide; D014025:Titanium