title: Spectral studies on a series of metal ion complexes derived from pyrimidine nucleus, TEM, biological and γ-irradiation effect.
abstract: A series of thiouracil complexes was prepared, all the prepared compounds are investigated by all possible tools. The ligand coordinates towards two central atoms as a neutral hexadentate mode. The octahedral structure was proposed with Ni(II), Pt(IV) and UO2(II) complexes. Square-pyramidal and square planar with VO(II) and Pd(II) complexes, respectively. VO(II) complex was irradiated by using Gamma radiation to through a light on the probability of geometry changes with the effect of radiation. The parameters calculated from ESR spectra before and after γ-irradiation reflect the rigidity of the complex towards the effect. Such may discuss the unaffected biological behavior before and after irradiation. XRD patterns were carried out to emphasis on the nature of the particles and the purity of products. The ligand, Pt(IV) and Pd(II) are found in nanometer range. TEM is a sensitive tool used to justify on the microstructure and surface morphology. All the investigated compounds are in nanorange. TG curves reflect a lower thermal stability of all investigated complexes due to the presence of water of crystallization. Finally, a toxic effect was observed with all investigated complexes towards Gram positive bacterium as well as a resistant behavior was observed with Gram negative bacteria.
authors: Chemistry Department, Faculty of Applied Science, Umm Al-Qura University, Makah, Saudi Arabia.
authors: Sawsan
authors: S
authors: Al-Ashqer
authors: Chem. Department, Fac. of Science, King Khalid University, Abha, Saudi Arabia.
authors: Khlood S
authors: KS
authors: Abou-Melha
authors: Chem. Department, Fac. of Science, King Khalid University, Abha, Saudi Arabia; Chemistry Department, Fac. of Applied Science, Taiz University, P.O. Box 82, Taiz, Yemen.
authors: G A A
authors: GA
authors: Al-Hazmi
authors: Chemistry Department, Faculty of Applied Science, Umm Al-Qura University, Makah, Saudi Arabia.
authors: Fawaz A
authors: FA
authors: Saad
authors: Chemistry Department, Faculty of Applied Science, Umm Al-Qura University, Makah, Saudi Arabia; Chemistry Department, Faculty of Science, Mansoura University, Egypt. Electronic address: n_elmetwaly00@yahoo.com.
authors: Nashwa M
authors: NM
authors: El-Metwaly
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology* / Q000528:radiation effects*; D004578:Electron Spin Resonance Spectroscopy; D004583:Electrons; D005720:Gamma Rays; D007477:Ions; D008024:Ligands; D060328:Magnetic Phenomena; D008826:Microbial Sensitivity Tests; D046529:Microscopy, Electron, Transmission; D008958:Models, Molecular; D011743:Pyrimidines / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013818:Thermogravimetry; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D056831:Coordination Complexes; D007477:Ions; D008024:Ligands; D011743:Pyrimidines; C030986:pyrimidine
keywords: Biological; Gamma rays; Modeling; Spectral; TEM; Thiouracil derivative