title: Association between SNP rs13376333 and rs1131820 in the KCNN3 gene and atrial fibrillation in the Chinese Han population.
abstract: BACKGROUND
  The small conductance calcium-activated potassium, subfamily N, member 3 (KCNN3) gene rs13376333 and rs1131820 have been shown to be strongly associated with lone atrial fibrillation (AF), while replication association studies between rs13376333 in KCNN3 gene and risk of AF showed conflicting results. The current study tried to validate the impact of SNP rs13376333 and rs1131820 of KCNN3 gene on the risk of AF in the Chinese Han population.
  
  
  METHODS
  A total of 889 AF patients and 1015 controls were enrolled. Two hundred and seventy-eight cases of AF were lone AF. KCNN3 gene SNP rs13376333 and rs1131820 were genotyped by allele-specific MALDI-TOF mass spectrometry.
  
  
  RESULTS
  The genotype distribution and allele frequency of rs13376333 polymorphism were not different between total AF patients and controls. However, the genotype distribution of rs13376333 polymorphism was significantly different between lone AF and control group (p<0.001); and T allele frequency was significantly higher in lone AF group than that in controls (7.6% vs 3.6%, p<0.001). Multivariable logistic regression analysis showed that T allele carriers of rs13376333 was significantly associated with lone AF (OR=2.31, 95% CI 1.41-3.78, p=0.001). No relationship between rs1131820 polymorphism and total AF or lone AF was found in this study.
  
  
  CONCLUSIONS
  KCNN3 rs13376333 polymorphism was associated with lone AF in the Chinese Han population and the T allele carriers may be an independent predictive factor for lone AF.
authors: Zhurong
authors: Z
authors: Luo
authors: Chenghui
authors: C
authors: Yan
authors: Wenli
authors: W
authors: Zhang
authors: Xiaoli
authors: X
authors: Shen
authors: Weixing
authors: W
authors: Zheng
authors: Fengping
authors: F
authors: Chen
authors: Xiaozhi
authors: X
authors: Cao
authors: Yuhui
authors: Y
authors: Yang
authors: Xianliang
authors: X
authors: Lin
authors: Zhiqing
authors: Z
authors: Wang
authors: Mingfang
authors: M
authors: Huang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D001281:Atrial Fibrillation / Q000175:diagnosis / Q000235:genetics*; D002681:China; D003710:Demography; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D051640:Small-Conductance Calcium-Activated Potassium Channels / Q000235:genetics*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: C406328:KCNN3 protein, human; D051640:Small-Conductance Calcium-Activated Potassium Channels