title: Quantitative assessment of the association between HDMX polymorphism and sarcoma.
abstract: To investigate the effects of the HDMX polymorphism on sarcoma risk. Relevant studies were identified by searching the PubMed, Embase, and Web of Science databases. Data were extracted by two independent investigators. Odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated using a fixed-effects model to assess the association between the HDMX polymorphism and sarcoma risk. We also conducted heterogeneity test, sensitivity analysis, and publication bias test. A meta-analysis of four published case-control studies involving 1,115 subjects (379 cases and 736 controls) showed no statistical association between the HDMX polymorphism and sarcoma risk (ORTT vs. GG 0.88, 95 % CI 0.68-1.14, P heterogeneity 0.819; ORTT + TG vs. GG 0.95, 95 % CI 0.79-1.15, P heterogeneity 0.937; ORTT vs. TG + GG 0.82, 95 % CI 0.65-1.04, P heterogeneity 0.589; ORT allele vs. G allele 0.91, 95 % CI 0.79-1.05, P heterogeneity 0.727; ORTG vs. GG 0.95, 95 % CI 0.74-1.22, P heterogeneity = 0.869). This null result did not alter when data were stratified according to ethnicity. Our meta-analysis indicates that the HDMX polymorphism is unlikely to contribute to individual susceptibility to sarcoma.
authors: Department of Orthopedics of Jinling Hospital, Nanjing University, School of Medicine, 305 Zhongshan East Rd, Nanjing, 210002, China.
authors: Haidong
authors: H
authors: Xu
authors: Panyu
authors: P
authors: Zhou
authors: Yunfan
authors: Y
authors: Ti
authors: Fengyu
authors: F
authors: Jia
mesh_terms: D000483:Alleles; D001859:Bone Neoplasms / Q000235:genetics / Q000473:pathology; D016022:Case-Control Studies; D018797:Cell Cycle Proteins; D016208:Databases, Factual; D005260:Female; D005838:Genotype; D006801:Humans; D009687:Nuclear Proteins / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D012509:Sarcoma / Q000235:genetics* / Q000473:pathology; D014594:Uterine Neoplasms / Q000235:genetics / Q000473:pathology
chemical_list: D018797:Cell Cycle Proteins; C482775:MDM4 protein, human; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins