title: Severe traumatic brain injury management and clinical outcome using the Lund concept.
abstract: This review covers the main principles of the Lund concept for treatment of severe traumatic brain injury. This is followed by a description of results of clinical studies in which this therapy or a modified version of the therapy has been used. Unlike other guidelines, which are based on meta-analytical approaches, important components of the Lund concept are based on physiological mechanisms for regulation of brain volume and brain perfusion and to reduce transcapillary plasma leakage and the need for plasma volume expanders. There have been nine non-randomized and two randomized outcome studies with the Lund concept or modified versions of the concept. The non-randomized studies indicated that the Lund concept is beneficial for outcome. The two randomized studies were small but showed better outcome in the groups of patients treated according to the modified principles of the Lund concept than in the groups given a more conventional treatment.
authors: Department of Pharmacology and Clinical Neuroscience, Neurosurgery, Umeå University, Sweden. Electronic address: Lars-Owe.Koskinen@neuro.umu.se.
authors: L-O D
authors: LO
authors: Koskinen
authors: Department of Pharmacology and Clinical Neuroscience, Neurosurgery, Umeå University, Sweden; Department of Anaesthesia and Intensive Care, University of Örebro, Sweden.
authors: M
authors: M
authors: Olivecrona
authors: Department of Clinical Science in Lund, Anaesthesia and Intensive Care, Lund University, Sweden.
authors: P O
authors: PO
authors: Grände
mesh_terms: D001930:Brain Injuries / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D019468:Disease Management; D006801:Humans; D007427:Intracranial Pressure / Q000502:physiology; D017410:Practice Guidelines as Topic; D013548:Sweden
keywords: Lund concept; management; outcome; severe traumatic brain injury