title: In search of a surrogate: engineering human beta cell lines for therapy.
abstract: Replacement of insulin-producing cells is a promising therapy for the restoration of the beta cell mass that is destroyed in patients with type 1 diabetes (T1D). However, the use of large amounts of islets per transplant, coupled with the scarcity of donor tissue, diminishes its feasibility. Here we briefly discuss current progress in developing ideal functional beta cells as well as the rationale for developing renewable sources of insulin-producing cells that can be transplanted.
authors: Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610-0275, USA.
authors: Brittney N
authors: BN
authors: Newby
authors: Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610-0275, USA.
authors: Naohiro
authors: N
authors: Terada
authors: Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610-0275, USA. Electronic address: clayton.mathews@pathology.ufl.edu.
authors: Clayton E
authors: CE
authors: Mathews
mesh_terms: D002460:Cell Line; D003922:Diabetes Mellitus, Type 1 / Q000628:therapy*; D006801:Humans; D050417:Insulin-Secreting Cells / Q000166:cytology / Q000637:transplantation*; D016381:Islets of Langerhans Transplantation / Q000379:methods*
keywords: beta cells; embryonic stem cell; induced pluripotent stem cell; islet cell transplantation; type 1 diabetes