title: Access to pyridyl-substituted 1,3,5-triazines from 4H-pyrido[1,3]oxazin-4-ones via a cyclocondensation process.
abstract: Pyridyl-substituted 1,3,5-triazines were synthesized in good to excellent yields via an unprecedented one-step cyclocondensation of 4H-pyrido[1,3]oxazin-4-ones with amidines at room temperature or under microwave irradiations. The broad applicability was demonstrated by 33 examples with a variety of amidines and three different 4H-pyrido[1,3]oxazin-4-one chemical series. In addition, a one-pot process from 4H-pyrido[1,3]oxazin-4-one precursors (imide sodium salts) was developed and led to the desired triazines compounds, thus allowing a one-step economy in their global synthetic preparation. This approach provides rapid access to pyridyl (or pyridone)-substituted 1,3,5-triazines with high potential in various fields of application.
authors: Exploratory Unit, Sanofi R&D , 1 Avenue Pierre Brossolette, 91385 Chilly Mazarin Cedex, France.
authors: Laetitia
authors: L
authors: Le Falher
authors: Omar
authors: O
authors: Ben Ayad
authors: Ozge
authors: O
authors: Ziyaret
authors: Alexander
authors: A
authors: Mamontov
authors: Candice
authors: C
authors: Botuha
authors: Serge
authors: S
authors: Thorimbert
authors: Franck
authors: F
authors: Slowinski
mesh_terms: D003500:Cyclization; D015394:Molecular Structure; D010078:Oxazines / Q000737:chemistry*; D014227:Triazines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D010078:Oxazines; D014227:Triazines