title: Slow-MAS NMR: A new technology for in vivo metabolomic studies.
abstract: Obtaining detailed in vivo metabolic information has been identified as key elements of better understanding the efficacy and toxicity of new therapies. A new nuclear magnetic resonance (NMR) technology called LOCMAT is reported in this paper that yields substantially increased spectral resolution in spatially localized in vivo H NMR metabolite spectra, as illustrated by measurements in the liver of a live mouse. LOCMAT promises to significantly enhance the utility of NMR spectroscopy for biomedical research.:
authors: Pacific Northwest National Laboratory, P.O. Box 999, MS K8-98, 3335 Q Avenue, Richland, WA 99352, USA. Electronic address:robert.wind@pnl.gov.
authors: Robert A
authors: RA
authors: Wind
authors: Pacific Northwest National Laboratory, P.O. Box 999, MS K8-98, 3335 Q Avenue, Richland, WA 99352, USA.
authors: Jian Z
authors: JZ
authors: Hu
authors: Pacific Northwest National Laboratory, P.O. Box 999, MS K8-98, 3335 Q Avenue, Richland, WA 99352, USA.
authors: Paul D
authors: PD
authors: Majors