title: Gastric-type endocervical glandular neoplasms associated with aberrant p16 expression and K-RAS gene mutation in Peutz-Jeghers syndrome.
abstract: In this report, unique endocervical glandular lesions exhibiting gastric differentiation were examined in a patient with Peutz-Jeghers syndrome. The result of the human papillomavirus (HPV) in situ hybridization (ISH) for the hysterectomy specimens was negative, but they demonstrated a papillary mucinous adenocarcinoma at the proximal endocervix continuous to atypical lobular endocervical glandular hyperplasia. Both contained MUC6-positive neutral mucin in cytoplasm, and showed different immunoreactivity to p16, Ki-67, and p53. Moreover, they harbored the identical K-RAS gene mutation suggesting that there was a common origin. Somatic K-RAS mutation and defective function of p16 may have been involved in the tumorigenesis of these unusual mucinous neoplasms.
authors: Department of Pathology, Miyagi Cancer Center, Natori, Japan.
authors: Shigemi
authors: S
authors: Ito
authors: Toru
authors: T
authors: Tase
authors: Kennichi
authors: K
authors: Satoh
authors: Miyuki
authors: M
authors: Ueki
authors: Ikuro
authors: I
authors: Sato
authors: Hironobu
authors: H
authors: Sasano
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000150:complications / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D019941:Cyclin-Dependent Kinase Inhibitor p16; D005260:Female; D006801:Humans; D009154:Mutation; D009363:Neoplasm Proteins / Q000378:metabolism*; D010580:Peutz-Jeghers Syndrome / Q000150:complications / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D016283:Proto-Oncogene Proteins p21(ras); D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D055815:Young Adult; D018631:ras Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: C000614131:CDKN2A protein, human; D019941:Cyclin-Dependent Kinase Inhibitor p16; C117307:KRAS protein, human; D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins; D016283:Proto-Oncogene Proteins p21(ras); D018631:ras Proteins
keywords: K-RAS; Peutz-Jeghers syndrome; cervical adenocarcinoma; lobular endocervical glandular hyperplasia; p16