title: Health technology assessment in evolution - focal therapy in localised prostate cancer.
abstract: Focal therapy in prostate cancer aims to treat only the part of the gland harboring clinically significant disease while preserving the rest of the tissue. This approach may substantially reduce treatment-related toxicity without compromising disease control outcomes. Short- to medium-term functional and oncological results in prospective interventional studies are promising, but comparative effectiveness research against standard of care is required to incorporate focal therapy among standard options. In this review, we discuss the actual stage of assessment and results of sources of energy commonly used to deliver focal therapy. We also provide our viewpoint on how the field will evolve in the near future.
authors: Division of Surgery and Interventional Science, University College London, London, UK.
authors: Massimo
authors: M
authors: Valerio
authors: Mark
authors: M
authors: Emberton
authors: Eric
authors: E
authors: Barret
authors: Daniel
authors: D
authors: Eberli
authors: Scott E
authors: SE
authors: Eggener
authors: Behfar
authors: B
authors: Ehdaie
authors: Patrice
authors: P
authors: Jichlinski
authors: John F
authors: JF
authors: Ward
authors: Hashim U
authors: HU
authors: Ahmed
mesh_terms: D017679:Cryotherapy / Q000379:methods / Q000639:trends; D053672:Electrochemotherapy / Q000379:methods / Q000639:trends; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D013673:Technology Assessment, Biomedical / Q000379:methods / Q000639:trends*; D014464:Ultrasonic Therapy / Q000379:methods / Q000639:trends
keywords: focal therapy; health technology assessment; minimally invasive treatment; prostate cancer; tissue-preserving approaches