title: Triterpenoids with anti-tobacco mosaic virus activities from Melia toosendan.
abstract: Four new triterpenoids, named Toosendansins A-D (1-4), along with nine known ones (5-13) were isolated from the fruits of Melia toosendan Sieb. et Zucc. Their structures were established on the basis of spectroscopic data. The isolation of compounds 1-12 were reported for the first time from this plant. All compounds were analyzed for the anti-Tobacco Mosaic Virus (TMV) activity and protective effect on H2O2-induced damage of SH-SY5Y cells. Compound 7 showed evident anti-TMV activity. Compounds 2 and 9 exhibited modest protection against H2O2-induced damage of SH-SY5Y cells.
authors: College of Pharmacy, Guizhou University, Guiyang 550025, China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, China.
authors: Lin
authors: L
authors: Chen
authors: The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, China.
authors: Jian-Xin
authors: JX
authors: Zhang
authors: The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, China.
authors: Bin
authors: B
authors: Wang
authors: The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, China. Electronic address: muzi0558@126.com.
authors: Shu-Zhen
authors: SZ
authors: Mu
authors: The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, China.
authors: Xiao-Jiang
authors: XJ
authors: Hao
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002460:Cell Line; D006801:Humans; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031585:Melia / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D014027:Tobacco Mosaic Virus / Q000187:drug effects*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D000998:Antiviral Agents; D036701:Limonins; D014315:Triterpenes
keywords: Anti-tobacco mosaic virus activities; Limonoids; Melia toosendan; Triterpenoids