title: Value of amplitude-integrated electroencephalograph in early diagnosis and prognosis prediction of neonatal hypoxic-ischemic encephalopathy.
abstract: To investigate value of amplitude-integrated electroencephalograph (aEEG) in early diagnosis and prediction of long-term prognosis of neonatal hypoxic-ischemic encephalopathy (HIE), 120 HIE Children were randomly assigned into aEEG group and control group (n = 60 per group). Children in each group were sub-divided into mild, moderate and severe HIE groups (n = 20 per group). 1, 3, 14 and 28 days after birth, aEEG was performed in aEEG group; 3, 14 and 28 days after birth, neonatal behavioral neurological assessment (NBNA) was done in both groups. Children who discharged were followed up at adjusted gestational age of 12 months with Denver Developmental Screening Test (DDST) and prognosis evaluation.
  
  
  RESULTS
  aEEG manifestation was positively related to clinical severityb of HIE (r = 0.843, P < 0.01). On day 3 and 14, NBNA score was comparable between two groups (P > 0.05), but significant difference in NBNA score was noted on day 28 (P < 0.05). On day 3, 14 and 28, aEEG manifestation was positively associated with prognosis at adjusted gestational age of 12 months (r = 0.832, 0.857, 0.778, 0.743, P < 0.01). In aEEG group, disability rate was 13.8%, which was significantly lower than that in control group (23.2%); cure rate in aEEG group (60%) was significantly higher than that in control group (40%). Moreover, long-term prognosis was also dramatically different between aEEG group and control group (χ(2) = 4.107, P < 0.05).
  
  
  CONCLUSIONS
  aEEG manifestation is significantly associated with clinical severity of HIE and may be helpful for early diagnosis of HIE. aEEG may be used to predict long term prognosis of HIE children.
authors: Affiliated Bayi Children's Hospital, Beijing Military Region General Hospital No. 5 Nan Mencang, Dongcheng District, Beijing 100700, China.
authors: Xiao-Juan
authors: XJ
authors: Yin
authors: Affiliated Bayi Children's Hospital, Beijing Military Region General Hospital No. 5 Nan Mencang, Dongcheng District, Beijing 100700, China.
authors: Wei
authors: W
authors: Wei
authors: Affiliated Bayi Children's Hospital, Beijing Military Region General Hospital No. 5 Nan Mencang, Dongcheng District, Beijing 100700, China.
authors: Tao
authors: T
authors: Han
authors: Affiliated Bayi Children's Hospital, Beijing Military Region General Hospital No. 5 Nan Mencang, Dongcheng District, Beijing 100700, China.
authors: Ming-Xia
authors: MX
authors: Shang
authors: Affiliated Bayi Children's Hospital, Beijing Military Region General Hospital No. 5 Nan Mencang, Dongcheng District, Beijing 100700, China.
authors: Xiao
authors: X
authors: Han
authors: Affiliated Bayi Children's Hospital, Beijing Military Region General Hospital No. 5 Nan Mencang, Dongcheng District, Beijing 100700, China.
authors: Yan-Nan
authors: YN
authors: Chai
authors: Affiliated Bayi Children's Hospital, Beijing Military Region General Hospital No. 5 Nan Mencang, Dongcheng District, Beijing 100700, China.
authors: Zhi-Chun
authors: ZC
authors: Feng
keywords: Amplitude-integrated electroencephalograph; early diagnosis; neonatal hypoxic-ischemic encephalopathy; prognosis