title: Bushen Huoxue decoction improves cognitive decline in rats with cerebral hypoperfusion.
abstract: Cerebral hypoperfusion is a common feature of vascular dementia and has recently been recognized to contribute to the progression of cognitive decline. The present study aimed to investigate the effects of Bushen Huoxue decoction (BHD), a two‑herb Chinese Medicine, on cognitive impairment in a rat model of cerebral hypoperfusion induced by permanent occlusion of bilateral common carotid arteries (2VO). The results demonstrated that BHD significantly attenuated learning and spatial memory deficits in the Morris water maze test in a dose‑dependent manner. Transmission electron microscopy observation revealed that the reduction of synapse density in hippocampal CA1 and cortex parietal isolated from rats with 2VO was partially restored by BHD treatment. In addition, the expression levels of a number of antioxidants, including superoxide dismutase, catalase (CAT), glutathine and glutathione peroxidase‑1 (GPx‑1) increased, whereas malondialdehyde decreased in the hippocampi of rats with 2VO following BHD treatment. Polymerase chain reaction and western blot analysis further confirmed that the GPx‑1 and CAT expression increased in the BHD treatment group. In conclusion the results suggested that BHD has therapeutic potential to treat vascular dementia, which may be associated with synapse density and anti‑oxidant activities in the hippocampus.
authors: Academy of Integrative Medicine Fujian, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, P.R. China.
authors: Shuifen
authors: S
authors: Ye
authors: School of Chinese Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China.
authors: Yong
authors: Y
authors: Gu
authors: Academy of Integrative Medicine Fujian, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, P.R. China.
authors: Yihui
authors: Y
authors: Xu
authors: Academy of Integrative Medicine Fujian, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, P.R. China.
authors: Wen
authors: W
authors: Fan
authors: College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, P.R. China.
authors: Xiaoting
authors: X
authors: Wang
authors: College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, P.R. China.
authors: Shuting
authors: S
authors: Chen
authors: College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, P.R. China.
authors: Siyi
authors: S
authors: Cai
authors: College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, P.R. China.
authors: Shirong
authors: S
authors: Lv
authors: School of Chinese Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China.
authors: Yao
authors: Y
authors: Tong
authors: Academy of Integrative Medicine Fujian, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, P.R. China.
authors: Jing
authors: J
authors: Cai
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002545:Brain Ischemia / Q000188:drug therapy*; D002374:Catalase / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D003071:Cognition / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005979:Glutathione Peroxidase / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D007858:Learning / Q000187:drug effects; D008315:Malondialdehyde / Q000378:metabolism; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000188:drug therapy; D046529:Microscopy, Electron, Transmission; D018696:Neuroprotective Agents / Q000494:pharmacology*; D008517:Phytotherapy; D028321:Plant Preparations / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D000094765:Glutathione Peroxidase GPX1
chemical_list: D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents; D028321:Plant Preparations; C527851:bushen huoxue; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D000094765:Glutathione Peroxidase GPX1; C000722069:Gpx1 protein, rat