title: Characterization of amyloid in equine recurrent uveitis as AA amyloid.
abstract: Two horses with chronic uveitis and histological lesions consistent with equine recurrent uveitis (ERU) were examined. Microscopical findings in the ciliary body included deposits of amyloid lining the non-pigmented epithelium, intracytoplasmic, rod-shaped, eosinophilic inclusions and intraepithelial infiltration of T lymphocytes. Ultrastructural examination of the ciliary body of one horse confirmed the presence of abundant extracellular deposits of non-branching fibrils (9-11 nm in diameter) consistent with amyloid. Immunohistochemistry revealed strong positive labelling for AA amyloid and mass spectrometry showed the amyloid to consist primarily of serum amyloid A1 in both cases. The findings suggest that localized, intraocular AA amyloidosis may occur in horses with ERU.
authors: Faculty of Veterinary Medicine and Biosciences, Department of Basic Sciences and Aquatic Medicine, Norwegian University of Life Sciences, Norway. Electronic address: liv.ostevik@nmbu.no.
authors: L
authors: L
authors: Ostevik
authors: Department of Internal Medicine, Diakonhjemmet Hospital, Norway.
authors: G A
authors: GA
authors: de Souza
authors: Department of Immunology and Transfusion Medicine, Oslo University Hospital, University of Oslo, Oslo, Norway.
authors: T N
authors: TN
authors: Wien
authors: Faculty of Veterinary Medicine and Biosciences, Department of Basic Sciences and Aquatic Medicine, Norwegian University of Life Sciences, Norway.
authors: G
authors: G
authors: Gunnes
authors: Faculty of Veterinary Medicine and Biosciences, Department of Basic Sciences and Aquatic Medicine, Norwegian University of Life Sciences, Norway.
authors: R
authors: R
authors: Sørby
mesh_terms: D000686:Amyloidosis / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D005260:Female; D006734:Horse Diseases / Q000473:pathology*; D006736:Horses; D008297:Male; D000685:Serum Amyloid A Protein; D014605:Uveitis / Q000473:pathology / Q000662:veterinary*
chemical_list: D000685:Serum Amyloid A Protein
keywords: AA amyloidosis; equine recurrent uveitis; mass spectrometry