title: Main ion channels and receptors associated with visceral hypersensitivity in irritable bowel syndrome.
abstract: Irritable bowel syndrome (IBS) is a very frequent functional gastrointestinal disorder characterized by recurrent abdominal pain or discomfort and alteration of bowel habits. The IBS physiopathology is extremely complex. Visceral hypersensitivity plays an important role in the pathogenesis of abdominal pain in bothin vitroandin vivomodels of this functional disorder. In order to obtain a general view of the participation of the main ion channels and receptors regarding the visceral hypersensitivity in the IBS and to describe their chemical structure, a literature review was carried out. A bibliographical research in the following electronic databases: Pubmed and Virtual Library in Health (BVS) was fulfilled by using the search terms "ion channels" "or" "receptors" "and" "visceral hypersensitivity" "or" "visceral nociception" "and" "irritable bowel syndrome". Original and review articles were considered for data acquisition. The activation of the ATP ion-gated channels, voltage-gated sodium (Nav) and calcium (Cav) channels, as well as the activation of protease-activated receptors (PAR2), transient receptor potential vanilloide-1, serotonin, cannabinoids and cholecystokinin are involved in the genesis of visceral hypersensitivity in IBS. The involvement of ion channels and receptors concerning visceral hypersensitivity is noteworthy in IBS models.
authors: Health Sciences Center (Heraldo Arcela de Carvalho Rocha, Bruna Priscilla Vasconcelos Dantas, Thaísa Leite Rolim, Bagnólia Araújo Costa), Federal University of Paraíba, Cidade Universitária, Campus I, João Pessoa, PB, Brazil ; Medical Sciences Center (Heraldo Arcela de Carvalho Rocha, Arnaldo Correira de Medeiros), Federal University of Paraíba, Cidade Universitária, Campus I, João Pessoa, PB, Brazil.
authors: Heraldo Arcela
authors: HA
authors: de Carvalho Rocha
authors: Health Sciences Center (Heraldo Arcela de Carvalho Rocha, Bruna Priscilla Vasconcelos Dantas, Thaísa Leite Rolim, Bagnólia Araújo Costa), Federal University of Paraíba, Cidade Universitária, Campus I, João Pessoa, PB, Brazil.
authors: Bruna Priscilla Vasconcelos
authors: BP
authors: Dantas
authors: Health Sciences Center (Heraldo Arcela de Carvalho Rocha, Bruna Priscilla Vasconcelos Dantas, Thaísa Leite Rolim, Bagnólia Araújo Costa), Federal University of Paraíba, Cidade Universitária, Campus I, João Pessoa, PB, Brazil.
authors: Thaísa Leite
authors: TL
authors: Rolim
authors: Health Sciences Center (Heraldo Arcela de Carvalho Rocha, Bruna Priscilla Vasconcelos Dantas, Thaísa Leite Rolim, Bagnólia Araújo Costa), Federal University of Paraíba, Cidade Universitária, Campus I, João Pessoa, PB, Brazil.
authors: Bagnólia Araújo
authors: BA
authors: Costa
authors: Medical Sciences Center (Heraldo Arcela de Carvalho Rocha, Arnaldo Correira de Medeiros), Federal University of Paraíba, Cidade Universitária, Campus I, João Pessoa, PB, Brazil.
authors: Arnaldo Correia
authors: AC
authors: de Medeiros
keywords: Visceral hypersensitivity; ion channels; irritable bowel syndrome