title: Enantioselective phospha-Michael addition of diarylphosphines to β,γ-unsaturated α-ketoesters and amides.
abstract: An enantioselective hydrophosphination of β,γ-unsaturated α-ketoesters and amides has been developed using a chiral palladacycle catalyst. Adducts can be obtained in excellent yields and enantioselectivities, providing direct access to chiral tertiary phosphines which are synthetically useful intermediates in the preparation of bidentate ligands.
authors: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore. pakhing@ntu.edu.sg.
authors: Renta Jonathan
authors: RJ
authors: Chew
authors: Kai Yuan
authors: KY
authors: Teo
authors: Yinhua
authors: Y
authors: Huang
authors: Bin-Bin
authors: BB
authors: Li
authors: Yongxin
authors: Y
authors: Li
authors: Sumod A
authors: SA
authors: Pullarkat
authors: Pak-Hing
authors: PH
authors: Leung