title: Determination of absolute configuration via vibrational circular dichroism.
abstract: Vibrational circular dichroism (VCD) provides a growing and promising technology for the determination of the absolute configuration of molecules in solution, including drug molecules. The practical application of VCD spectroscopy consists of the experimental determination and comparison to quantum chemically calculated data. The key features of the VCD technology are presented and an example of an application of the technique is discussed.:
authors: Department of Inorganic and Physical Chemistry, Ghent University, Krijgslaan 281 (S3), B-9000 Gent, Belgium.
authors: Tom
authors: T
authors: Kuppens
authors: Department of Inorganic and Physical Chemistry, Ghent University, Krijgslaan 281 (S3), B-9000 Gent, Belgium. Electronic address:patrick.bultinck@ugent.be.
authors: Patrick
authors: P
authors: Bultinck
authors: Janssen Pharmaceutica N.V., PAS Specification Management, Lammerdries 55, 2250 Olen, Belgium.
authors: Wilfried
authors: W
authors: Langenaeker