title: Anticancer substances of mushroom origin.
abstract: The present status of investigations about the anticancer activity which is inherent to medicinal mushrooms, as well as their biomedical potential and future prospects are discussed. Mushroom products and extracts possess promising immunomodulating and anticancer effects, so the main biologically active substances of mushrooms responsible for immunomodulation and direct cytoto-xicity toward cancer cell lines (including rarely mentioned groups of anticancer mushroom proteins), and the mechanisms of their antitumor action were analyzed. The existing to date clinical trials of mushroom substances are mentioned. Mushroom anticancer extracts, obtained by the different solvents, are outlined. Modern approaches of cancer treatment with implication of mushroom products, including DNA vaccinotherapy with mushroom immunomodulatory adjuvants, creation of prodrugs with mushroom lectins that can recognize glycoconjugates on the cancer cell surface, development of nanovectors etc. are discussed. The future prospects of mushroom anticancer substances application, including chemical modification of polysaccharides and terpenoids, gene engineering of proteins, and implementation of vaccines are reviewed.
authors: Institute of Food Biotechnology and Genomics of National Academy of Sciences of Ukraine, Kyiv 04123, Ukraine.
authors: T S
authors: TS
authors: Ivanova
authors: Institute of Food Biotechnology and Genomics of National Academy of Sciences of Ukraine, Kyiv 04123, Ukraine.
authors: T A
authors: TA
authors: Krupodorova
authors: Institute of Food Biotechnology and Genomics of National Academy of Sciences of Ukraine, Kyiv 04123, Ukraine.
authors: V Y
authors: VY
authors: Barshteyn
authors: RE Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, Kyiv 03022, Ukraine.
authors: A B
authors: AB
authors: Artamonova
authors: RE Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, Kyiv 03022, Ukraine.
authors: V A
authors: VA
authors: Shlyakhovenko
mesh_terms: D000363:Agaricales / Q000737:chemistry*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001688:Biological Products / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products