title: New dihydro-β-agarofuran sesquiterpenes from Parnassia wightiana wall: isolation, identification and cytotoxicity against cancer cells.
abstract: Five new (4-8) and three known (1-3) dihydro-β-agarofuran sesquiterpene polyesters were isolated from the whole plants of Parnassia wightiana. The structures of all compounds were elucidated through spectroscopic analysis including 2D-NMR and HR-MS. The absolute configuration of these compounds was established by X-ray diffraction analysis, comparison of NOESY spectra and biogenetic means. The cytotoxities of compounds 2-8 were evaluated in vitro against HL-60, SMMC-7721, A549, MCF-7 and SW480 cell lines. Compounds 5-7 exhibited the highest activities with IC₅₀ values of 11.8-30.1 μM in most cases. The SAR revealed that the introduction of hydroxyl group was able to significantly improve the activities of the compounds for most of the cell lines.
authors: College of Science, Northwest A&F University, Yangling 712100, China. dear.chao.lu@gmail.com.
authors: Chao
authors: C
authors: Lv
authors: College of Science, Northwest A&F University, Yangling 712100, China. zhengzuolue@gmail.com.
authors: Zuo-Lue
authors: ZL
authors: Zheng
authors: College of Life Science, Northwest A&F University, Yangling 712100, China. miaofangmf@163.com.
authors: Fang
authors: F
authors: Miao
authors: College of Science, Northwest A&F University, Yangling 712100, China. genghuiling5@163.com.
authors: Hui-Ling
authors: HL
authors: Geng
authors: College of Science, Northwest A&F University, Yangling 712100, China. zhoulechem@nwsuaf.edu.cn.
authors: Le
authors: L
authors: Zhou
authors: College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China. llp-sx@163.com.
authors: La-Ping
authors: LP
authors: Liu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D029753:Celastraceae / Q000737:chemistry* / Q000378:metabolism; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D061986:MCF-7 Cells; D008968:Molecular Conformation; D010936:Plant Extracts / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D013329:Structure-Activity Relationship
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D012717:Sesquiterpenes; C079978:dihydroagarofuran