title: The IL-6/IL-6R/sgp130 system and Th17 associated cytokines in patients with gestational diabetes.
abstract: BACKGROUND
  Interleukin-6 (IL-6) is a pleiotropic cytokine which signals through a cell surface receptor complex consisting of a cognatereceptor subunit (IL-6R) and glycoprotein 130 (gp130), which is considered an antagonist to the IL-6R/IL-6 pathway. The aim of the present study was to assess IL-6/IL-6R/gp130 system and Th17 associated cytokines in different time points during and after pregnancy in women with gestational diabetes mellitus (GDM) and normal glucose tolerance (NGT).
  
  
  METHODS
  Serum levels of IL-6, sIL6R, sgp130, IL-17 and IL-23 were measured in 91 women divided into three groups: GDMin the 24th-28th week of gestation (visit 1), NGT at the 1st visit and GDM in the 29th-32nd week, and NGT at both visits.
  
  
  RESULTS
  The patients with GDM recognised at the 1st visit had significantly higher IL-6 (p = 0.02) and sgp130 (p = 0.03) concentrations than had the women with NGT, whereas the women with GDM diagnosed at the 2nd visit had elevated sIL-6R concentrations (p = 0.03). The patients with low sIL-6R but high sgp130 concentration had significantly higher glucose levels (p = 0.04) and lower IL-6 values (p = 0.04) than had the patients with low sIL-6R and sgp130 concentrations. IL-17 and IL-23 were detected in approximately one-third of the population studied. A trend towards higher IL-17 levels was observed in the subjects with GDM, but the differences were not significant.
  
  
  CONCLUSIONS
  Our results suggest that an increased serum sgp130 concentration in the patients with GDM might represent a compensatory mechanism, controlling intracellular IL-6 signalling and preventing the activation of the IL-6/IL-6R pathway.
authors: mkuzmicki@op.pl.
authors: Mariusz
authors: M
authors: Kuźmicki
authors: Beata
authors: B
authors: Telejko
authors: Danuta
authors: D
authors: Lipińska
authors: Justyna
authors: J
authors: Pliszka
authors: Juliusz
authors: J
authors: Wilk
authors: Natalia
authors: N
authors: Wawrusiewicz-Kurylonek
authors: Anna
authors: A
authors: Zielińska
authors: Angelika
authors: A
authors: Sobota
authors: Adam
authors: A
authors: Krętowski
authors: Maria
authors: M
authors: Górska
authors: Jacek
authors: J
authors: Szamatowicz
mesh_terms: D000328:Adult; D050822:Cytokine Receptor gp130 / Q000097:blood*; D016640:Diabetes, Gestational / Q000097:blood / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D011247:Pregnancy; D012307:Risk Factors; D058504:Th17 Cells / Q000378:metabolism*; D055815:Young Adult
chemical_list: C508717:IL17A protein, human; C508600:IL6 protein, human; D020381:Interleukin-17; D015850:Interleukin-6; D050822:Cytokine Receptor gp130