title: White matter microstructural organization and gait stability in older adults.
abstract: Understanding age-related decline in gait stability and the role of alterations in brain structure is crucial. Here, we studied the relationship between white matter microstructural organization using Diffusion Tensor Imaging (DTI) and advanced gait stability measures in 15 healthy young adults (range 18-30 years) and 25 healthy older adults (range 62-82 years). Among the different gait stability measures, only stride time and the maximum Lyapunov exponent (which quantifies how well participants are able to attenuate small perturbations) were found to decline with age. White matter microstructural organization (FA) was lower throughout the brain in older adults. We found a strong correlation between FA in the left anterior thalamic radiation and left corticospinal tract on the one hand, and step width and safety margin (indicative of how close participants are to falling over) on the other. These findings suggest that white matter FA in tracts connecting subcortical and prefrontal areas is associated with the implementation of an effective stabilization strategy during gait.
authors: Motor Control Laboratory, Movement Control and Neuroplasticity Research Group, Department of Kinesiology, KU Leuven Leuven, Belgium ; Faculty of Human Movement Sciences, Research Institute MOVE, VU University Amsterdam, Netherlands ; Department of Orthopedics, First Affiliated Hospital of Fujian Medical University Fuzhou, China.
authors: Sjoerd M
authors: SM
authors: Bruijn
authors: Motor Control Laboratory, Movement Control and Neuroplasticity Research Group, Department of Kinesiology, KU Leuven Leuven, Belgium.
authors: Annouchka
authors: A
authors: Van Impe
authors: Motor Control Laboratory, Movement Control and Neuroplasticity Research Group, Department of Kinesiology, KU Leuven Leuven, Belgium ; Department of Research, Development and Education, Sint Maartenskliniek Nijmegen, Netherlands.
authors: Jacques
authors: J
authors: Duysens
authors: Motor Control Laboratory, Movement Control and Neuroplasticity Research Group, Department of Kinesiology, KU Leuven Leuven, Belgium ; Leuven Research Institute for Neuroscience & Disease Leuven, Belgium.
authors: Stephan P
authors: SP
authors: Swinnen
keywords: DTI; ageing; extrapolated center of mass; gait stability; maximum Lyapunov exponent; step width; white matter integrity