title: Correlation of nucleotides and carbohydrates metabolism with pro-oxidant and antioxidant systems of erythrocytes depending on age in patients with colorectal cancer.
abstract: OBJECTIVE
  To examine the relationship between metabolic features of purine nucleotides and antioxidant system depending on the age of patients with colorectal cancer.
  
  
  METHODS
  The activity of adenosine deaminase, xanthine oxidase, glutathione peroxidase, superoxide dismutase and glucose-6-phosphate dehydrogenase, the NOx concentration and the oxidative modification of proteins were determined spectrophotometricaly in 50 apparently healthy people and 26 patients with colorectal cancer stage -III---IV, aged 40 to 79 years.
  
  
  RESULTS
  Increase of pro-oxidant system of erythrocytes with the age against decrease in level of antioxidant protection in both healthy individuals and colorectal cancer patients was determined. A significant increase of pro-ducts of oxidative proteins modification in erythrocytes with ageing was shown. Statistically significant correlation between enzymatic and non enzymatic markers pro-oxidant system and the activity of antioxidant defense enzymes in erythrocytes of patient with colorectal cancer was determined.
  
  
  CONCLUSIONS
  Obtained results have demonstrated the imbalance in the antioxidant system of erythrocytes in colorectal cancer patients that improve the survival of cancer cells that is more distinctly manifested in ageing.
authors: Department of Chemistry, Maksim Gorky National Medical University, Donetsk 83003, Ukraine.
authors: S A
authors: SA
authors: Zuikov
authors: Department of Chemistry, Maksim Gorky National Medical University, Donetsk 83003, Ukraine.
authors: B G
authors: BG
authors: Borzenko
authors: Department of Chemistry, Maksim Gorky National Medical University, Donetsk 83003, Ukraine.
authors: O P
authors: OP
authors: Shatova
authors: Department of Chemistry, Maksim Gorky National Medical University, Donetsk 83003, Ukraine.
authors: E M
authors: EM
authors: Bakurova
authors: Department of General Surgery and Surgical Diseases, Maksim Gorky National Medical University, Donetsk 83003, Ukraine.
authors: G E
authors: GE
authors: Polunin
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009711:Nucleotides / Q000378:metabolism*; D016877:Oxidants / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D017382:Reactive Oxygen Species
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D009711:Nucleotides; D016877:Oxidants; D017382:Reactive Oxygen Species