title: A single consumption of curry improved postprandial endothelial function in healthy male subjects: a randomized, controlled crossover trial.
abstract: BACKGROUND
  Curry, one of the most popular foods in Japan, contains spices that are rich in potentially antioxidative compounds, such as curcumin and eugenol. Oxidative stress is thought to impair endothelial function associated with atherosclerosis, a leading cause of cardiovascular events. The aim of this study was to determine whether a single consumption of curry meal would improve endothelial function in healthy men.
  
  
  METHODS
  Fourteen healthy male subjects (BMI 23.7 ± 2.7 kg/m2; age 45 ± 9 years) were given a single serving of curry meal or spice-free control meal (180 g of curry or control and 200 g of cooked rice; approximately 500 kcal in total) in a randomized, controlled crossover design. Before and 1 hr after the consumption, fasting and postprandial flow-mediated vasodilation (FMD) responses and other parameters were measured.
  
  
  RESULTS
  The consumption of the control meal decreased FMD from 5.8 ± 2.4% to 5.1 ± 2.3% (P = 0.039). On the other hand, the consumption of the curry meal increased FMD from 5.2 ± 2.5% to 6.6 ± 2.0% (P = 0.001), and the postprandial FMD after the curry meal was higher than that after the control meal (P = 0.002). Presence of spices in the curry did not alter significantly the systemic and forearm hemodynamics, or any biochemical parameters including oxidative stress markers measured.
  
  
  CONCLUSIONS
  These findings suggest that the consumption of curry ameliorates postprandial endothelial function in healthy male subjects and may be beneficial for improving cardiovascular health.
  
  
  BACKGROUND
  UMIN Clinical Trials Registry 000012012.
authors: Research & Development Institute, House Foods Corporation, Yotsukaido 284-0033, Japan. hideki-nakayama@housefoods.co.jp.
authors: Hideki
authors: H
authors: Nakayama
authors: Nobuaki
authors: N
authors: Tsuge
authors: Hiroshi
authors: H
authors: Sawada
authors: Noriya
authors: N
authors: Masamura
authors: Shohei
authors: S
authors: Yamada
authors: Shigeki
authors: S
authors: Satomi
authors: Yukihito
authors: Y
authors: Higashi
mesh_terms: D000328:Adult; D018592:Cross-Over Studies; D003474:Curcumin / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000503:physiopathology; D005054:Eugenol / Q000494:pharmacology; D005502:Food; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period / Q000502:physiology; D014664:Vasodilation / Q000187:drug effects*
chemical_list: D005054:Eugenol; D003474:Curcumin