title: Complexity of cytokine network regulation of innate lymphoid cells in protective immunity.
abstract: The body's surface provides a critical barrier shielding us from various mechanical and pathogenic insults by virtue of the physical protection it provides and the presence of specialized populations of innate lymphoid cells (ILCs) that sense inflammatory signals induced by pathogens. This response plays a central role in the development and activation of early immune responses. While ILCs depend on common γ-chain cytokine signaling for their development, an essential component of the armory of these cells is their capacity to produce defensive cytokines when activated by viruses, microbes and other parasites. In this review, we describe the multiple intrinsic and extrinsic pathways that comprise the cytokine circuitry regulating the development and function of ILC necessary for protective immunity.
authors: Division of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Melbourne, Victoria 3010, Australia. Electronic address: seillet@wehi.edu.au.
authors: Cyril
authors: C
authors: Seillet
authors: Division of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Melbourne, Victoria 3010, Australia. Electronic address: belz@wehi.edu.au.
authors: Gabrielle T
authors: GT
authors: Belz
authors: Division of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Melbourne, Victoria 3010, Australia. Electronic address: mielke@wehi.edu.au.
authors: Lisa A
authors: LA
authors: Mielke
mesh_terms: D056704:Adaptive Immunity / Q000276:immunology; D016207:Cytokines / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D007249:Inflammation / Q000276:immunology / Q000378:metabolism; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism; D018448:Models, Immunological; D015398:Signal Transduction / Q000276:immunology*
chemical_list: D016207:Cytokines
keywords: Development; Homeostasis; Inflammation; Innate immunity; infection