title: Use of contrast-enhanced fluid-attenuated inversion recovery sequence to detect brain lesions in dogs and cats.
abstract: BACKGROUND
  The diagnostic value of a contrast-enhanced T2-weighted FLAIR sequence (ceFLAIR) in brain imaging is unclear.
  
  
  OBJECTIVE
  That the number of brain lesions detected with ceFLAIR would be no greater than the sum of lesions detected with nFLAIR and ceT1W sequence.
  
  
  METHODS
  One hundred and twenty-nine animals (108 dogs and 21 cats) undergoing magnetic resonance imaging (MRI) of the head between July 2010 and October 2011 were included in the study.
  
  
  METHODS
  A transverse ceFLAIR was added to a standard brain MRI protocol. Presence and number of lesions were determined based on all available MRI sequences by 3 examiners in consensus and lesion visibility was evaluated for nFLAIR, ceFLAIR, and ceT1W sequences.
  
  
  RESULTS
  Eighty-three lesions (58 intra-axial and 25 extra-axial) were identified in 51 patients. Five lesions were detected with nFLAIR alone, 2 with ceT1W alone, and 1 with ceFLAIR alone. Significantly higher numbers of lesions were detected using ceFLAIR than nFLAIR (76 versus 67 lesions; P = 0.04), in particular for lesions also detected with ceT1W images (53 versus 40; P =.01). There was no significant difference between the number of lesions detected with combined nFLAIR and ceT1W sequences compared to those detected with ceFLAIR (82 versus 76; P =.25).
  
  
  CONCLUSIONS
  Use of ceFLAIR as a complementary sequence to nFLAIR and ceT1W sequences did not improve the detection of brain lesions and cannot be recommended as part of a routine brain MRI protocol in dogs and cats with suspected brain lesions.
authors: Division of Clinical Radiology, Department of Clinical Veterinary Medicine, Vetsuisse-Faculty Bern, Bern, Switzerland.
authors: K
authors: K
authors: Merhof
authors: J
authors: J
authors: Lang
authors: S
authors: S
authors: Dürr
authors: C
authors: C
authors: Stahl
authors: D
authors: D
authors: Gorgas
mesh_terms: D000818:Animals; D001927:Brain Diseases / Q000175:diagnosis / Q000662:veterinary*; D002371:Cat Diseases / Q000175:diagnosis*; D002415:Cats; D003287:Contrast Media; D004283:Dog Diseases / Q000175:diagnosis*; D004285:Dogs; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000662:veterinary*; D059906:Neuroimaging / Q000379:methods / Q000662:veterinary*
chemical_list: D003287:Contrast Media
keywords: Contrast enhancement; Intracranial lesions; Magnetic resonance imaging