title: [Composition and antitumor activities of essential oil from the fruits of Dasymaschalon trichophorum].
abstract: OBJECTIVE
  To study the chemical components and antitumor activities of essential oil from the fruits of Dasymaschalon trichophorum.
  
  
  METHODS
  The essential oil from the fruits of Dasymaschalon trichophorum was extracted by steam-stilling and analyzed by GC-MS. The inhibitory effect of extract of Dasymaschalon trichophorum on SPCA-1,BEL-7402, SGC-7901 and K-562 cell proliferation was assayed using the MTU.
  
  
  RESULTS
  GC-MS result showed that there were 55 peaks and 30 compounds were identified which weighed 74.98%. The major components were nerolidol (19.887%), caryophyllene (16.714%) and beta-myrcene (9.29%). The essential oil exhibited strong antitumor activity against SPCA-1 human tumor cell line with IC50 value of 6.61 microg/mL.
  
  
  CONCLUSIONS
  This experiment provides scientific foundation for further utilization of Dasymaschalon trichophorum.
authors: Xiao-bao
authors: XB
authors: Li
authors: Guang-ying
authors: GY
authors: Chen
authors: Xiao-ping
authors: XP
authors: Song
authors: Chang-ri
authors: CR
authors: Han
authors: Cai-juan
authors: CJ
authors: Zheng
mesh_terms: D000080462:Acyclic Monoterpenes; D029061:Annonaceae / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D005638:Fruit / Q000737:chemistry; D008401:Gas Chromatography-Mass Spectrometry; D006358:Hot Temperature; D006801:Humans; D020128:Inhibitory Concentration 50; D039821:Monoterpenes / Q000032:analysis; D009822:Oils, Volatile / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000032:analysis
chemical_list: D000080462:Acyclic Monoterpenes; D000972:Antineoplastic Agents, Phytogenic; D039821:Monoterpenes; D009822:Oils, Volatile; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C008574:beta-myrcene; C024714:caryophyllene; C037055:nerolidol