title: The impact of a diphenyl diselenide-supplemented diet and aerobic exercise on memory of middle-aged rats.
abstract: Selenium is an essential trace element for human health and has received attention for its role as a nutrient. The combination of exercise and nutrients has been proposed to promote health. The aim of this study was to determine the effects of a diet supplemented with diphenyl diselenide (PhSe)2 and swimming exercise on memory of middle-aged rats. Male Wistar rats (12months) received standard diet chow supplemented with 1ppm of (PhSe)2 for 4weeks. Rats were submitted to swimming training (20min per day for 4weeks). After 4weeks, memory was evaluated in the object recognition test (ORT) and in the object location test (OLT). The hippocampal levels of phosphorylated cAMP-response element-binding protein (CREB) were determined. The results of the present study demonstrated that the association of (PhSe)2-supplemented diet and swimming exercise improved short-term memory, long-term memory and spatial learning, and this effect was not related to the increase in hippocampal p-CREB levels in middle-age rats. This study also revealed that middle-aged rats in the swimming exercise group had the best performance in short- and long-term memory. In conclusion, we demonstrated that swimming exercise, (PhSe)2-supplemented diet or the association of these factors improved learning and memory functioning. The hippocampal levels of CREB were not directly related to the benefits of swimming exercise and (PhSe)2-supplemented diet association in memory of middle-aged rats.
authors: Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, Rio Grande do Sul, Brazil.
authors: José L
authors: JL
authors: Cechella
authors: Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, Rio Grande do Sul, Brazil.
authors: Marlon R
authors: MR
authors: Leite
authors: Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, Rio Grande do Sul, Brazil.
authors: Rafaela M
authors: RM
authors: Gai
authors: Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, Rio Grande do Sul, Brazil. Electronic address: gzeni@quimica.ufsm.br.
authors: Gilson
authors: G
authors: Zeni
mesh_terms: D000818:Animals; D001555:Benzene Derivatives / Q000494:pharmacology*; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D004032:Diet; D019587:Dietary Supplements; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D016566:Organoselenium Compounds / Q000494:pharmacology*; D010766:Phosphorylation / Q000187:drug effects; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013550:Swimming
chemical_list: D001555:Benzene Derivatives; D017362:Cyclic AMP Response Element-Binding Protein; D016566:Organoselenium Compounds; C061132:diphenyldiselenide
keywords: Age; Diet; Exercise; Memory; Organoselenium; Selenium