title: Broad-spectrum catalysts for the ambient temperature anti-Markovnikov hydration of alkynes.
abstract: Anti-Markovnikov alkyne hydration provides a valuable route to aldehydes. Half-sandwich ruthenium complexes ligated by 5,5'-bis(trifluoromethyl)-2,2'-bipyridine are remarkably active for this transformation. In the presence of 2 mol % metal, a wide range of functionalized aliphatic and aromatic alkynes are hydrated in high yield at ambient temperature.
authors: Department of Chemistry, Yale University, 225 Prospect Street, New Haven, CT 06520-8107 (USA).
authors: Le
authors: L
authors: Li
authors: Mingshuo
authors: M
authors: Zeng
authors: Seth B
authors: SB
authors: Herzon
keywords: alkynes; bipyridines; homogeneous catalysis; hydration; ruthenium