title: Enzymatic glycosylation of vancomycin aglycon: completion of a total synthesis of vancomycin and N- and C-terminus substituent effects of the aglycon substrate.
abstract: Studies on the further development of the sequential glycosylations of the vancomycin aglycon catalyzed by the glycosyltransferases GtfE and GtfD and the observation of unusual, perhaps unexpected, aglycon substrate substituent effects on the rate and efficiency of the initial glycosylation reaction are reported.
authors: Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
authors: Atsushi
authors: A
authors: Nakayama
authors: Akinori
authors: A
authors: Okano
authors: Yiqing
authors: Y
authors: Feng
authors: James C
authors: JC
authors: Collins
authors: Karen C
authors: KC
authors: Collins
authors: Christopher T
authors: CT
authors: Walsh
authors: Dale L
authors: DL
authors: Boger
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D005964:Glucosyltransferases / Q000378:metabolism; D006031:Glycosylation; D015394:Molecular Structure; D014640:Vancomycin / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin; D005964:Glucosyltransferases; C113848:glucosyltransferase D; C430144:glucosyltransferase E