title: Percutaneous microwave ablation of stage I medically inoperable non-small cell lung cancer: clinical evaluation of 47 cases.
abstract: OBJECTIVE
  To retrospectively evaluate safety and effectiveness of CT-guided percutaneous microwave ablation (MWA) in 47 patients with medically inoperable stage I peripheral non-small cell lung cancer (NSCLC).
  
  
  METHODS
  From February 2008 to October 2012, 47 patients with stage I medically inoperable NSCLC were treated in 47 MWA sessions. The clinical outcomes were evaluated. Complications after MWA were also summarized.
  
  
  RESULTS
  At a median follow-up period of 30 months, the median time to the first recurrence was 45.5 months. The local control rates at 1, 3, 5 years after MWA were 96%, 64%, and 48%, respectively. The median cancer-specific and median overall survivals were 47.4 and 33.8 months. The overall survival rates at 1, 2, 3, and 5 years after MWA were 89%, 63%, 43%, and 16%, respectively. Tumors ≤3.5 cm were associated with better survival than were tumors >3.5 cm. The complications after MWA included pneumothorax (63.8%), hemoptysis (31.9%), pleural effusion (34%), pulmonary infection (14.9%), and bronchopleural fistula (2.1%).
  
  
  CONCLUSIONS
  MWA is safe and effective for the treatment of medically inoperable stage I peripheral NSCLC.
authors: Department of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.
authors: Xia
authors: X
authors: Yang
authors: Xin
authors: X
authors: Ye
authors: Aimin
authors: A
authors: Zheng
authors: Guanghui
authors: G
authors: Huang
authors: Xiang
authors: X
authors: Ni
authors: Jiao
authors: J
authors: Wang
authors: Xiaoying
authors: X
authors: Han
authors: Wenhong
authors: W
authors: Li
authors: Zhigang
authors: Z
authors: Wei
mesh_terms: D055011:Ablation Techniques / Q000009:adverse effects; D000368:Aged; D000369:Aged, 80 and over; D001983:Bronchial Fistula / Q000209:etiology; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006469:Hemoptysis / Q000209:etiology; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D008297:Male; D008872:Microwaves / Q000627:therapeutic use*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010996:Pleural Effusion / Q000209:etiology; D011014:Pneumonia / Q000209:etiology; D011030:Pneumothorax / Q000209:etiology; D015641:Radiography, Interventional; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
keywords: CT-guided; microwave ablation; non-small cell lung cancer; percutaneous