title: In vivo characterization of a decellularized dermis-polymer complex for use in percutaneous devices.
abstract: To develop a method for making percutaneous devices that have high biocompatibility and do not induce downgrowth of epidermal cells, we prepared a partial decellularized dermis (DD)/poly(methyl methacrylate) (PMMA) complex (PDPC) with a PMMA rod firmly stabilized inside. The porcine decellularized tissue was chosen because of its high biocompatibility and mechanical properties, and MMA was used because it would adhere firmly to a polymer such as a catheter. The MMA filled the cavities in the dermis and polymerized, anchoring to the collagenous fibrils inside the porcine DD. The PDPC was cemented to the PMMA rod tightly and it was integrated with the surrounding tissue within 12 weeks of implantation. Furthermore, no downgrowth of the epidermis, which may cause clinical problems, was observed. We consider that the tissue-polymer complex may be a suitable candidate for use in percutaneous devices.
authors: Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan; CREST, Japan Science and Technology Agency, Tokyo, Japan.
authors: Kwangwoo
authors: K
authors: Nam
authors: Rie
authors: R
authors: Matsushima
authors: Tsuyoshi
authors: T
authors: Kimura
authors: Toshiya
authors: T
authors: Fujisato
authors: Akio
authors: A
authors: Kishida
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D020405:Dermis; D005109:Extracellular Matrix; D008297:Male; D008422:Materials Testing; D011108:Polymers; D019736:Prostheses and Implants; D051381:Rats; D017208:Rats, Wistar; D013552:Swine
chemical_list: D001672:Biocompatible Materials; D011108:Polymers
keywords: Decellularization; Dermis; Poly(methyl methacrylate); Tissue-polymer complex; percutaneous device