title: Effects of glutathione S-transferase M1 and T1 deletions on epilepsy risk among a Tunisian population.
abstract: Glutathione-S-transferases enzymes are involved in the detoxification of several endogenous and exogenous substances. In this present study, we evaluated the effects of two glutathione-S-transferase polymorphisms, (GSTM1 and GSTT1) on epilepsy risk susceptibility in a Tunisian population. These polymorphisms were analyzed in 229 healthy subjects and 98 patients with epilepsy, using a polymerase chain reaction (PCR). Odds ratio (ORs) was used for analyzing results. The study results demonstrated that individuals with the GSTM1 null genotype were at an increased risk of developing epilepsy [OR=3.80, 95% confidence interval (CI) (2.15-4.78)], whereas no significant effects were observed between individuals with GSTT1 null genotype and epilepsy risk [OR=1.15, 95% CI (0.62-2.12)]. These genotyping finding revealed that the absence of GSTM1 activity could be contributor factor for the development of epilepsy disease.
authors: Metabolic Biophysics, Professional Toxicology and Applied Environmental Laboratory, Department of Biophysics, Medicine Faculty of Sousse, Sousse University, Sousse 4002, Tunisia. Electronic address: chahra.chbili@yahoo.com.
authors: Chahra
authors: C
authors: Chbili
authors: Metabolic Biophysics, Professional Toxicology and Applied Environmental Laboratory, Department of Biophysics, Medicine Faculty of Sousse, Sousse University, Sousse 4002, Tunisia; Laboratory of Natural Substances, National Institute of Research and Physical-Chemical Analysis (INRAP), Technopole Sidi Thabet 2020, Tunisia.
authors: Fatma
authors: F
authors: B'chir
authors: Metabolic Biophysics, Professional Toxicology and Applied Environmental Laboratory, Department of Biophysics, Medicine Faculty of Sousse, Sousse University, Sousse 4002, Tunisia.
authors: Maha
authors: M
authors: Ben Fredj
authors: Metabolic Biophysics, Professional Toxicology and Applied Environmental Laboratory, Department of Biophysics, Medicine Faculty of Sousse, Sousse University, Sousse 4002, Tunisia.
authors: Bochra-Nourhène
authors: BN
authors: Saguem
authors: Neurology Department of Central Hospital University (CHU), Sousse University, Sousse 4002, Tunisia.
authors: Sana
authors: S
authors: Ben Amor
authors: Neurology Department of Central Hospital University (CHU), Sousse University, Sousse 4002, Tunisia.
authors: Sofiene
authors: S
authors: Ben Ammou
authors: Metabolic Biophysics, Professional Toxicology and Applied Environmental Laboratory, Department of Biophysics, Medicine Faculty of Sousse, Sousse University, Sousse 4002, Tunisia. Electronic address: khaled_saguem@yahoo.fr.
authors: Saad
authors: S
authors: Saguem
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004252:DNA Mutational Analysis; D004827:Epilepsy / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005982:Glutathione Transferase / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D014416:Tunisia / Q000453:epidemiology; D055815:Young Adult
chemical_list: D005982:Glutathione Transferase; C413545:glutathione S-transferase T1
keywords: Epilepsy-genetic polymorphisms; Glutathione-S-transferase M1; Glutathione-S-transferase T1