title: Sphingosine-1-phosphate modulates dendritic cell function: focus on non-migratory effects in vitro and in vivo.
abstract: Dendritic cells (DCs) are the cutting edge in innate and adaptive immunity. The major functions of these antigen-presenting cells are the capture, endosomal processing and presentation of antigens, providing them an exclusive ability to provoke adaptive immune responses and to induce and control tolerance. Immature DCs capture and process antigens, migrate towards secondary lymphoid organs where they present antigens to naive T cells in a well-synchronized sequence of procedures referred to as maturation. Indeed, recent research indicated that sphingolipids are modulators of essential steps in DC homeostasis. It has been recognized that sphingolipids not only modulate the development of DC subtypes from precursor cells but also influence functional activities of DCs such as antigen capture, and cytokine profiling. Thus, it is not astonishing that sphingolipids and sphingolipid metabolism play a substantial role in inflammatory diseases that are modulated by DCs. Here we highlight the function of sphingosine 1-phosphate (S1P) on DC homeostasis and the role of S1P and S1P metabolism in inflammatory diseases.
authors: Pharmazentrum Frankfurt/ZAFES, Clinic of the Goethe University, Frankfurt, Germany.
authors: Olga
authors: O
authors: Arlt
authors: Anja
authors: A
authors: Schwiebs
authors: Lukasz
authors: L
authors: Japtok
authors: Katja
authors: K
authors: Rüger
authors: Elisabeth
authors: E
authors: Katzy
authors: Burkhard
authors: B
authors: Kleuser
authors: Heinfried H
authors: HH
authors: Radeke
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D000941:Antigens / Q000276:immunology; D016207:Cytokines / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007113:Immunity, Innate; D008246:Lysophospholipids / Q000378:metabolism*; D012871:Skin Diseases / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000378:metabolism; D051193:Toll-Like Receptors / Q000378:metabolism; D059467:Transcriptome
chemical_list: D000941:Antigens; D016207:Cytokines; D008246:Lysophospholipids; D051193:Toll-Like Receptors; C060506:sphingosine 1-phosphate; D013110:Sphingosine