title: Pregnancy outcomes of prenatally diagnosed Turner syndrome: a French multicenter retrospective study including a series of 975 cases.
abstract: OBJECTIVE
  The objectives of this study were to report pregnancy outcomes after prenatal diagnosis of Turner syndrome (TS) and to compare and assess termination of pregnancy rates during two periods. The intervals selected were before and after 1997 when multidisciplinary centers for prenatal diagnosis (MCPDs) were established in France.
  
  
  METHODS
  A database of 975 cases of TS diagnosed between 1980 and 2012 was created from 21 French cytogenetics laboratories. For each case, the karyotype indication, maternal age, year of prenatal testing, sampling procedure, karyotype, associated ultrasound findings, and outcomes were recorded.
  
  
  RESULTS
  Karyotypes were mainly performed because of abnormal sonographic findings (84%). Before 1997, there were no changes in the rate of termination (90%) of affected fetuses. After 1997, the rate fell to 80%. This decrease was mainly observed in cases of mosaicism, incidental diagnosis, and in later gestations. US abnormalities were more likely to be associated with a full 45,X karyotype.
  
  
  CONCLUSIONS
  There was an evolution in the way genetic counseling was performed following prenatal diagnosis of Turner syndrome that coincided with the opening of MCPDs in France. This resulted in a decrease in the rate of termination of affected fetuses.
authors: Laboratoire de cytogénétique prénatale, Service de Génétique, CHU Côte de Nacre, UFR de Médecine Caen, Caen Cedex 9, France.
authors: N
authors: N
authors: Gruchy
authors: F
authors: F
authors: Vialard
authors: E
authors: E
authors: Blondeel
authors: N
authors: N
authors: Le Meur
authors: G
authors: G
authors: Joly-Hélas
authors: P
authors: P
authors: Chambon
authors: M
authors: M
authors: Till
authors: M
authors: M
authors: Herbaut-Graux
authors: A
authors: A
authors: Vigouroux-Castera
authors: A
authors: A
authors: Coussement
authors: J
authors: J
authors: Lespinasse
authors: F
authors: F
authors: Amblard
authors: M
authors: M
authors: Jimenez
authors: L
authors: L
authors: Lebel Roy Camille
authors: F
authors: F
authors: Carré-Pigeon
authors: E
authors: E
authors: Flori
authors: F
authors: F
authors: Mugneret
authors: S
authors: S
authors: Jaillard
authors: C
authors: C
authors: Yardin
authors: R
authors: R
authors: Harbuz
authors: M
authors: M
authors: Collonge Rame
authors: P
authors: P
authors: Vago
authors: M
authors: M
authors: Valduga
authors: N
authors: N
authors: Leporrier
mesh_terms: D000028:Abortion, Induced / Q000706:statistics & numerical data*; D000328:Adult; D005260:Female; D005602:France / Q000453:epidemiology; D005817:Genetic Counseling / Q000458:organization & administration; D006801:Humans; D007621:Karyotyping / Q000706:statistics & numerical data; D048208:Nuchal Translucency Measurement; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D014424:Turner Syndrome / Q000000981:diagnostic imaging*