title: [SFGM-TC recommendation on indications for allogeneic stem cell transplantation in children with congenital neutropenia].
abstract: In this report, we address the issue of allogeneic stem cell transplantation in children with congenital neutropenia. Constitutional disorders with neutropenia are exceptional. Treatment and prevention of severe infections are a major concern in the management of chronic neutropenia. These disorders, especially Kostmann's disease and Shwachman-Bodian-Diamond syndrome, are associated with an increased risk of leukemia. The role of allogeneic stem cell transplantation in these patients is still unclear. In an effort to harmonize clinical practices between different French transplantation centers, the French Society of Bone Marrow Transplantation and Cell Therapy (SFGM-TC) set up the fourth annual series of workshops which brought together practitioners from all member centers and took place in September 2013 in Lille.
authors: Unité d'hématologie-immunologie, hôpital Robert-Debré, 48, boulevard Serrurier, 75019 Paris, France.
authors: J-H
authors: JH
authors: Dalle
authors: Service d'hémato-onco-pédiatrie, hôpital Trousseau, 26, avenue du Dr-Arnold-Netter, 75571 Paris cedex 12, France.
authors: J
authors: J
authors: Donadieu
authors: Service d'hématologie et oncologie pédiatrique, CHU de Hautepierre, avenue Molière, 67098 Strasbourg cedex, France.
authors: C
authors: C
authors: Paillard
authors: Oncologie pédiatrique, CHU de Nantes, 1, place Alexis-Ricordeau, 44093 Nantes, France.
authors: F
authors: F
authors: Rialland
authors: Service d'hémato-oncologie pédiatrie, hôpital Charles-Nicolle, CHU, 1, rue Germont, 76031 Rouen cedex, France.
authors: P
authors: P
authors: Schneider
authors: Hématologie adulte, hôpital Necker, 149, rue de Sèvres, 75015 Paris, France.
authors: F
authors: F
authors: Sicre De Fontbrune
authors: Hématologie clinique, hôpital Saint-Éloi, CHU de Montpellier, 80, avenue Augustin-Fliche, 34295 Montpellier cedex 5, France.
authors: Y
authors: Y
authors: Hichri
authors: Service d'immuno-hématologie pédiatrique, hôpital Necker-Enfants-Malades, 149-161, rue de Sèvres, 75743 Paris cedex 15, France.
authors: B
authors: B
authors: Neven
authors: Maladies du sang, CHRU de Lille, rue Michel-Polonovski, 59037 Lille cedex, France. Electronic address: sfgm-tc-iya@live.fr.
authors: I
authors: I
authors: Yakoub-Agha
mesh_terms: D000293:Adolescent; D001855:Bone Marrow Diseases / Q000150:complications / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D000080984:Congenital Bone Marrow Failure Syndromes; D010188:Exocrine Pancreatic Insufficiency / Q000150:complications / Q000601:surgery; D005602:France; D006801:Humans; D007223:Infant; D007239:Infections; D007938:Leukemia; D008068:Lipomatosis / Q000150:complications / Q000601:surgery; D009503:Neutropenia / Q000150:complications / Q000151:congenital* / Q000601:surgery*; D012307:Risk Factors; D000081003:Shwachman-Diamond Syndrome; D033581:Stem Cell Transplantation / Q000379:methods* / Q000592:standards; D014184:Transplantation, Homologous / Q000379:methods* / Q000592:standards
keywords: Allogeneic stem cell transplantation; Allogreffe; Myelodysplasia; Myélodysplasie; Neutropénies constitutionnelles sévères; Pancytopenia; Pancytopénie; Pediatrics; Pédiatrie; Severe congenital neutropenia's