title: Increase in the dosage amount of vitamin D3 preparations by switching from calcium carbonate to lanthanum carbonate.
abstract: It is widely known that dialysis patients who are administered vitamin D preparations have a better prognosis than patients who are not. In this study, of 22 patients on maintenance dialysis who had been administered calcium (Ca) carbonate in our hospital, we investigated the dosage amount of vitamin D3 preparations after the phosphorus (P) binder was switched from Ca carbonate to the newly developed lanthanum carbonate (LC). After completely switching to LC, the dosage amount of oral vitamin D3 preparation (alfacalcidol equivalent) was significantly increased from 0.094 μg/day to 0.375 μg/day (P = 0.0090). No significant changes were observed in the values of serum corrected Ca, alkaline phosphatase, intact parathyroid hormone and P after switching. The administration of LC enabled complete cessation of the administration of Ca carbonate preparations, and increased the dosage amount of vitamin D3 preparations. Therefore, LC may be a useful P binder to improve patient prognosis.
authors: Department of Urology and Blood Purification, Kuratakai Eijin Clinic, Hiratsuka, Japan; Department of Urology, Kitasato University School of Medicine, Sagamihara, Japan; Cambodia-Japan Friendship Blood Purification Center, Sen Sok International University School of Medicine, Phnom Penh, Cambodia.
authors: Toru
authors: T
authors: Hyodo
authors: Junko
authors: J
authors: Kawakami
authors: Noriko
authors: N
authors: Mikami
authors: Haruki
authors: H
authors: Wakai
authors: Daisuke
authors: D
authors: Ishii
authors: Kazunari
authors: K
authors: Yoshida
authors: Masatsugu
authors: M
authors: Iwamura
authors: Miho
authors: M
authors: Hida
authors: Yasuhisa
authors: Y
authors: Kurata
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D002118:Calcium / Q000097:blood; D002119:Calcium Carbonate / Q000008:administration & dosage* / Q000627:therapeutic use; D002762:Cholecalciferol / Q000008:administration & dosage* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007811:Lanthanum / Q000008:administration & dosage* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D010758:Phosphorus / Q000097:blood; D011379:Prognosis; D006435:Renal Dialysis; D012189:Retrospective Studies
chemical_list: D010281:Parathyroid Hormone; D002762:Cholecalciferol; D010758:Phosphorus; C119467:lanthanum carbonate; D007811:Lanthanum; D000469:Alkaline Phosphatase; D002119:Calcium Carbonate; D002118:Calcium
keywords: calcium carbonate; lanthanum carbonate; patient prognosis; vitamin D3 preparations