title: [Preventive and remineralization effect over incipient lesions of caries decay by phosphopeptide-amorphous calcium phosphate].
abstract: INTRODUCTION. Dental caries continues to affect a large percentage of Mexican children and currently advises that if diagnosed at an early stage can be reversed with minimally invasive treatments. The casein phosphopeptide amorphous calcium phosphate known as CPP-ACP is a phosphoprotein capable of releasing calcium and phosphate ions in the oral environment promoting remineralization. OBJECTIVE. To evaluate the effect of CPP-ACP with fluoride added in a scholar preventive program. MATERIAL AND METHODS. A cuasi- experimental study was conducted in 104 schools of six years old. The children were classified into three groups and received six months biweekly applications of different treatments: casein phosphopeptide amorphous calcium phosphate added fluoride (CPP-ACPF), sodium fluoride (NaF) and a control group. Clinical evaluation was performed with the laser fluorescence technique (Diagnodent model 2095). 1340 teeth were included: 294 teeth with incipient lesions and 1,046 healthy teeth. Statistical tests of χ2 y Mc Nemar were used. RESULTS. In the group that received the application of CPP-ACPF, 38% of incipient carious lesions were remineralizing compared with 21% in the group receiving the NaF (p < 0.001) and 15% in the control group (p < 0.0001) The percentage of teeth free of caries were preserved in the therapy group phosphoprotein was the biggest. This group also showed the lower proportion of deep carious lesion development (p < 0.0001). CONCLUSION. The application biweekly for six months of CPP-ACPF showed a protective and remineralizing effect on incipient carious lesions. His action was better than the application of NaF. However, to reduce the impact from dental caries in schoolchildren is important to have a comprehensive preventive approach that includes promoting self-care, as well as the application of sealants.
authors: Facultad de Estudios Superiores Zaragoza. Universidad Nacional Autónoma de México.
authors: María Lilia Adriana
authors: ML
authors: Juárez-López
authors: Rosa Diana
authors: RD
authors: Hernández-Palacios
authors: Juan Carlos
authors: JC
authors: Hernández-Guerrero
authors: Dolores
authors: D
authors: Jiménez-Farfán
authors: Nelly
authors: N
authors: Molina-Frechero
mesh_terms: D002327:Cariostatic Agents / Q000008:administration & dosage*; D016022:Case-Control Studies; D002364:Caseins / Q000008:administration & dosage*; D002648:Child; D003731:Dental Caries / Q000517:prevention & control*; D005453:Fluorescence; D006801:Humans; D007834:Lasers; D012969:Sodium Fluoride / Q000008:administration & dosage; D017001:Tooth Demineralization / Q000517:prevention & control*; D014089:Tooth Remineralization / Q000379:methods*
chemical_list: D002327:Cariostatic Agents; D002364:Caseins; C447032:casein phosphopeptide-amorphous calcium phosphate nanocomplex; D012969:Sodium Fluoride