title: Neurofibrillar tangle surrogates: histone H1 binding to patterned phosphotyrosine peptide nanotubes.
abstract: Living cells contain a range of densely phosphorylated surfaces, including phospholipid membranes, ribonucleoproteins, and nucleic acid polymers. Hyperphosphorylated surfaces also accumulate in neurodegenerative diseases as neurofibrillar tangles. We have synthesized and structurally characterized a precisely patterned phosphotyrosine surface and establish this assembly as a surrogate of the neuronal tangles by demonstrating its high-affinity binding to histone H1. This association with nucleic acid binding proteins underscores the role such hyperphosphorylated surfaces may play in disease and opens functional exploration into protein-phosphorylated surface interactions in a wide range of other complex assemblies.
authors: Departments of Chemistry, Biology, and Physics, Emory University , Atlanta, Georgia 30322, United States.
authors: Sha
authors: S
authors: Li
authors: Anton N
authors: AN
authors: Sidorov
authors: Anil K
authors: AK
authors: Mehta
authors: Anthony J
authors: AJ
authors: Bisignano
authors: Dibyendu
authors: D
authors: Das
authors: W Seth
authors: WS
authors: Childers
authors: Erin
authors: E
authors: Schuler
authors: Zhigang
authors: Z
authors: Jiang
authors: Thomas M
authors: TM
authors: Orlando
authors: Keith
authors: K
authors: Berland
authors: David G
authors: DG
authors: Lynn
mesh_terms: D000818:Animals; D006657:Histones / Q000737:chemistry*; D006801:Humans; D045333:Nanotubes, Peptide / Q000737:chemistry* / Q000648:ultrastructure; D019000:Phosphotyrosine / Q000737:chemistry*
chemical_list: D006657:Histones; D045333:Nanotubes, Peptide; D019000:Phosphotyrosine