title: Fluid dynamics of aortic root dilation in Marfan syndrome.
abstract: Aortic root dilation and propensity to dissection are typical manifestations of the Marfan Syndrome (MS), a genetic defect leading to the degeneration of the elastic fibres. Dilation affects the structure of the flow and, in turn, altered flow may play a role in vessel dilation, generation of aneurysms, and dissection. The aim of the present work is the investigation in-vitro of the fluid dynamic modifications occurring as a consequence of the morphological changes typically induced in the aortic root by MS. A mock-loop reproducing the left ventricle outflow tract and the aortic root was used to measure time resolved velocity maps on a longitudinal symmetry plane of the aortic root. Two dilated model aortas, designed to resemble morphological characteristics typically observed in MS patients, have been compared to a reference, healthy geometry. The aortic model was designed to quantitatively reproduce the change of aortic distensibility caused by MS. Results demonstrate that vorticity released from the valve leaflets, and possibly accumulating in the root, plays a fundamental role in redirecting the systolic jet issued from the aortic valve. The altered systolic flow also determines a different residual flow during the diastole.
authors.affiliation: DICAA-Università di Cagliari, Cagliari, Italy. Electronic address: querzoli@unica.it.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Querzoli
authors.affiliation: DICEA-Sapienza Università di Roma, Roma, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Fortini
authors.affiliation: DICEA-Sapienza Università di Roma, Roma, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Espa
authors.affiliation: DICEA-Sapienza Università di Roma, Roma, Italy.
authors.forename: Martina
authors.initials: M
authors.lastname: Costantini
authors.affiliation: DICEA-Sapienza Università di Roma, Roma, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Sorgini
mesh_terms: D001011:Aorta / Q000502:physiology*; D001021:Aortic Valve / Q000502:physiology*; D003326:Coronary Circulation; D006801:Humans; D057446:Hydrodynamics; D008382:Marfan Syndrome / Q000503:physiopathology*
keywords: Aortic flow; Fluid dynamics; Marfan syndrome; Velocity mapping; Vortex dynamics