title: Sero-survey of polio antibodies during wild poliovirus outbreak in southern Xinjiang Uygur Autonomous Region, China.
abstract: BACKGROUND
  After being polio free for more than 10 years, an outbreak following importation of wild poliovirus (WPV) was confirmed in Xinjiang Uygur Autonomous Region, China, in 2011.
  
  
  METHODS
  A cross-sectional study was conducted prior to supplementary immunization activities (SIAs), immediately after the confirmation of the WPV outbreak. In selected prefectures, participants aged ≤ 60 years old who visited hospitals at county-level or above to have their blood drawn for reasons not related to the study, were invited to participate in our study. Antibody titers ≥ 8 were considered positive.
  
  
  RESULTS
  Among the 2,611 participants enrolled, 2,253 (86.3%), 2,283 (87.4%), and 1,989 (76.2%) were seropositive to P1, P2 and P3 respectively, and 1744 (66.8%) participants were seropositive to all the three serotypes. Lower antibody seropositivities and geometric mean titers were observed in children <1 year of age and in adults aged 15-39 years.
  
  
  CONCLUSIONS
  Serosurveys to estimate population immunity in districts at high risk of polio importation might be useful to gauge underlying population immunity gaps to polio and possibly to guide preparedness and response planning. Consideration should be given to older children and adults during polio risk assessment planning and outbreak response.
authors.affiliation: Expanded Program on Immunization, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Hai-Bo
authors.initials: HB
authors.lastname: Wang
authors.affiliation: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Shuang-Li
authors.initials: SL
authors.lastname: Zhu
authors.affiliation: Expanded Program on Immunization, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Jing-Shan
authors.initials: JS
authors.lastname: Zheng
authors.affiliation: Expanded Program on Immunization, Xinjiang Uygur autonomous region Center for Disease Control and Prevention, Urumqi city, Xinjiang Uygur autonomous region, China.
authors.forename: Ai-Li
authors.initials: AL
authors.lastname: Gou
authors.affiliation: Expanded Program on Immunization, Xinjiang Uygur autonomous region Center for Disease Control and Prevention, Urumqi city, Xinjiang Uygur autonomous region, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Cui
authors.affiliation: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Expanded Program on Immunization, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Gui-Jun
authors.initials: GJ
authors.lastname: Ning
authors.affiliation: Expanded Program on Immunization, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Chun-Xiang
authors.initials: CX
authors.lastname: Fan
authors.affiliation: Expanded Program on Immunization, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Yuan-Sheng
authors.initials: YS
authors.lastname: Chen
authors.affiliation: Expanded Program on Immunization, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Ke-Li
authors.initials: KL
authors.lastname: Li
authors.affiliation: Expanded Program on Immunization, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Yuan
authors.affiliation: Expanded Program on Immunization, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Ma
authors.affiliation: Expanded Program on Immunization, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Ma
authors.affiliation: Expanded Program on Immunization, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zheng
authors.affiliation: Expanded Program on Immunization, Xinjiang Uygur autonomous region Center for Disease Control and Prevention, Urumqi city, Xinjiang Uygur autonomous region, China.
authors.forename: Xin-Chun
authors.initials: XC
authors.lastname: Fan
authors.affiliation: Expanded Program on Immunization, Xinjiang Uygur autonomous region Center for Disease Control and Prevention, Urumqi city, Xinjiang Uygur autonomous region, China.
authors.forename: Xin-Lan
authors.initials: XL
authors.lastname: Li
authors.affiliation: Expanded Program on Immunization, Xinjiang Uygur autonomous region Center for Disease Control and Prevention, Urumqi city, Xinjiang Uygur autonomous region, China.
authors.forename: Hai-Shu
authors.initials: HS
authors.lastname: Tang
authors.affiliation: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Xiao-Lei
authors.initials: XL
authors.lastname: Li
authors.affiliation: Hunan Provincial Center for Disease Control and Prevention, Changsha, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Zhang
authors.affiliation: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Yan
authors.affiliation: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Dong-Yan
authors.initials: DY
authors.lastname: Wang
authors.affiliation: Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang, China.
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Cui
authors.affiliation: Liaoning Provincial Center for Disease Control and Prevention, Shenyang, China.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Ren
authors.affiliation: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhu
authors.affiliation: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Hui-Ling
authors.initials: HL
authors.lastname: Wang
authors.affiliation: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Jiang
authors.affiliation: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Hong-Qiu
authors.initials: HQ
authors.lastname: An
authors.affiliation: Tianjin Center for Disease Control and Prevention, Tianjin, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Wen-Bo
authors.initials: WB
authors.lastname: Xu
authors.affiliation: Expanded Program on Immunization, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Wen
authors.affiliation: Shandong University Institute for Prevention Medicine, Shandong Provincial Key Laboratory of Infectious Diseases Control and Prevention, Shandong Center for Disease Control and Prevention, Jinan city, Shandong Province, China.
authors.forename: Ai-Qiang
authors.initials: AQ
authors.lastname: Xu
authors.affiliation: Expanded Program on Immunization, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Hui-Ming
authors.initials: HM
authors.lastname: Luo
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011051:Poliomyelitis / Q000097:blood* / Q000453:epidemiology*; D017955:Poliovirus
chemical_list: D000914:Antibodies, Viral