title: Mitobolites: the elixir of life.
abstract: One of the biggest challenges in biology is to understand how mitochondria influence aging and age-related diseases. Chin et al. (2014) reveal how a mitochondrial metabolite (mitobolite) inhibits mitochondrial ATPase and extends lifespan by mimicking dietary restriction in worms.
authors.affiliation: Buck Institute for Research on Aging, Novato, CA 94945, USA.
authors.forename: Subhash D
authors.initials: SD
authors.lastname: Katewa
authors.affiliation: Buck Institute for Research on Aging, Novato, CA 94945, USA.
authors.forename: Amit
authors.initials: A
authors.lastname: Khanna
authors.affiliation: Buck Institute for Research on Aging, Novato, CA 94945, USA. Electronic address: kapahi@buckinstitute.org.
authors.forename: Pankaj
authors.initials: P
authors.lastname: Kapahi
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000187:drug effects*; D006801:Humans; D007656:Ketoglutaric Acids / Q000494:pharmacology*; D008136:Longevity / Q000502:physiology*; D025261:Mitochondrial Proton-Translocating ATPases / Q000378:metabolism*; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*
chemical_list: D007656:Ketoglutaric Acids; D058570:TOR Serine-Threonine Kinases; D025261:Mitochondrial Proton-Translocating ATPases