title: The multifaceted and controversial immunometabolic actions of adiponectin.
abstract: Adiponectin, one of the most abundant adipose-derived hormones, has variable actions in many tissues and organs. Although principally known for its insulin-sensitizing activity, recent data also highlight its homeostatic function, which is mediated both by direct actions on metabolic cells and indirectly through immunomodulatory effects on immune cells. Here we review the multifaceted immunometabolic actions of adiponectin and attempt to unify some of the contradictory reports on adiponectin function in inflammatory processes. We propose that a holistic understanding of adiponectin function can be garnered only from understanding its actions both on the immune system and on metabolism.
authors.affiliation: Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Sydney, Australia; Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Esmaili
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong; Department of Medicine, University of Hong Kong, Hong Kong.
authors.forename: Amin
authors.initials: A
authors.lastname: Xu
authors.affiliation: Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Sydney, Australia. Electronic address: jacob.george@sydney.edu.au.
authors.forename: Jacob
authors.initials: J
authors.lastname: George
mesh_terms: D052242:Adiponectin / Q000378:metabolism*; D000818:Animals; D004734:Energy Metabolism; D006706:Homeostasis; D006801:Humans; D007155:Immunologic Factors / Q000378:metabolism*; D007333:Insulin Resistance; D007728:Kupffer Cells / Q000276:immunology / Q000378:metabolism; D008264:Macrophages / Q000276:immunology / Q000378:metabolism; D008954:Models, Biological; D032342:Muscle Cells / Q000276:immunology / Q000378:metabolism; D054419:Receptors, Adiponectin / Q000819:agonists / Q000378:metabolism; D015398:Signal Transduction; D013583:Synovial Membrane / Q000276:immunology / Q000378:metabolism
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D007155:Immunologic Factors; D054419:Receptors, Adiponectin
keywords: adiponectin; glucose homeostasis; immunometabolism; insulin sensitivity