title: Association of vitamin D receptor gene polymorphism with the urine calcium level in nephrolithiasis patients.
abstract: Association of vitamin D receptor (VDR) gene polymorphism with the urine calcium level in nephrolithiasis patients from the published reports are still conflicting. This study was conducted to evaluate the relationship between VDR BsmI (rs1544410), Fok1 (rs2228570), TaqI (rs731236) and ApaI (rs7975232) gene polymorphism and urine calcium level in nephrolithiasis patients using meta-analysis method. The association studies were identified from PubMed, and Cochrane Library on 1 April 2014, and eligible investigations were included and synthesized using meta-analysis method. Four reports were recruited into this meta-analysis for the association of VDR BsmI, Fok1, TaqI and ApaI gene polymorphism with urine calcium level in nephrolithiasis patients. In this meta-analysis, VDR BsmI B allele and BB genotype, Fok1 f allele and ff genotype, TaqI, and ApaI gene polymorphism were not associated with urine calcium level in nephrolithiasis patients. However, the BsmI bb genotype and Fok1 FF genotype were associated with the urine calcium level in nephrolithiasis patients. In conclusion, VDR BsmI bb genotype and Fok1 FF genotype were associated with the urine calcium level in nephrolithiasis patients. However, more studies should be conducted to confirm it.
authors.affiliation: Department of Nephrology, The Sixth Affiliated Hospital, Sun Yat-Sen University , Guangzhou , China.
authors.forename: Tian-Biao
authors.initials: TB
authors.lastname: Zhou
authors.forename: Zong-Pei
authors.initials: ZP
authors.lastname: Jiang
authors.forename: Miao-Fang
authors.initials: MF
authors.lastname: Huang
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
mesh_terms: D000483:Alleles; D002118:Calcium / Q000652:urine; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D053040:Nephrolithiasis / Q000235:genetics* / Q000473:pathology; D018167:Receptors, Calcitriol / Q000235:genetics*; D012307:Risk Factors
chemical_list: D018167:Receptors, Calcitriol; D002118:Calcium
keywords: Gene polymorphism; meta-analysis; nephrolithiasis; urine calcium level; vitamin D receptor