title: Comparative evaluation of transdermal diclofenac patch with oral diclofenac as an analgesic modality following root coverage procedures.
abstract: Diclofenac sodium is a nonsteroidal anti-inflammatory drug and is effective in the management of pain following periodontal surgery. However, oral administration of diclofenac can lead to gastrointestinal (GI) complications. To overcome these drawbacks, diclofenac is formulated as a transdermal patch, which delivers the drug into systemic circulation through skin. Twenty patients were selected for root coverage procedures with subepithelial connective tissue grafts bilaterally. Following the surgical procedure on the control sites, oral diclofenac sodium 100 mg was administered QD for 3 days. Following the surgical procedure on the contralateral test site, a transdermal diclofenac patch (TDP) was applied every 24 hours for 3 days. The TDP was effective in postoperative pain control following root coverage procedures with subepithelial connective tissue grafts. Pain tolerance was higher with the TDP as compared to oral administration, as it did not cause any GI complications.
authors.forename: Devireddy Venkata
authors.initials: DV
authors.lastname: Tejaswi
authors.forename: M L V
authors.initials: ML
authors.lastname: Prabhuji
authors.forename: Shaeesta
authors.initials: S
authors.lastname: Khaleelahmed
mesh_terms: D000279:Administration, Cutaneous; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000700:Analgesics / Q000008:administration & dosage*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D004008:Diclofenac / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D014092:Tooth Root / Q000187:drug effects*; D055815:Young Adult
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac
keywords: diclofenac sodium; nonsteroidal anti-inflammatory drugs; pain; periodontal surgery; transdermal patch