title: Estimation of glomerular filtration rate in cynomolgus monkeys (Macaca fascicularis).
abstract: To estimate the glomerular filtration rate (GFR) in cynomolgus monkeys (Macaca fascicularis), a three-blood-sample method using iodixanol was assessed in comparison with the conventional multisample strategy using inulin. Iodixanol and inulin were coadministered intravenously 40 mg I/kg and 50 mg/kg, respectively, to male monkeys, followed by blood collection 60, 90 and 120 min later. A close correlation (r=0.96) was noted between the GFR values estimated by both methods. In clinically healthy monkeys, the basal values were determined to be 3.06 ± 0.50 ml/min/kg. This is the first report, suggesting that serum clearance of iodixanol is a ready-to-use tool for a screening the GFR in monkeys, although it is necessary to perform a more longitudinal study using animals with reduced renal function.
authors.affiliation: Cooperative Department of Veterinary Basic Medicine, Iwate University, Morioka 020-86550, Japan.
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Iwama
authors.forename: Tsubasa
authors.initials: T
authors.lastname: Sato
authors.forename: Ken
authors.initials: K
authors.lastname: Sakurai
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Takasuna
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Ichijo
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Furuhama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Satoh
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005919:Glomerular Filtration Rate / Q000502:physiology*; D007444:Inulin / Q000494:pharmacology; D008252:Macaca fascicularis / Q000502:physiology*; D008297:Male; D012016:Reference Values; D014283:Triiodobenzoic Acids / Q000494:pharmacology
chemical_list: D003287:Contrast Media; D014283:Triiodobenzoic Acids; D007444:Inulin; C044834:iodixanol