title: Palladium-catalyzed carbonylative α-arylation to β-ketonitriles.
abstract: A carbonylative α-arylation process employing unactivated nitriles for the first time is described. The reaction tolerates a range of (hetero)aryl iodides and several nitrile coupling partners. No prefunctionalization of the nitriles is necessary and the resulting β-ketonitriles are obtained in good to excellent yields. The methodology also allows for a convenient (13) C-labelling of the generated carbonyl moiety.
authors.affiliation: Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Straße 29a, 18059 Rostock (Germany), Fax: (+49) 381-1281-5000.
authors.forename: Johannes
authors.initials: J
authors.lastname: Schranck
authors.forename: Mia
authors.initials: M
authors.lastname: Burhardt
authors.forename: Christoph
authors.initials: C
authors.lastname: Bornschein
authors.forename: Helfried
authors.initials: H
authors.lastname: Neumann
authors.forename: Troels
authors.initials: T
authors.lastname: Skrydstrup
authors.forename: Matthias
authors.initials: M
authors.lastname: Beller
keywords: carbonylation; palladium; α-arylation; β-ketonitriles