title: Stressing the limits of focal adhesion mechanosensitivity.
abstract: Focal adhesion assembly and maturation often occurs concomitantly with changes in force generated within the cytoskeleton or extracellular matrix. To coordinate focal adhesion dynamics with force, it has been suggested that focal adhesion dynamics are mechanosensitive. This review discusses current understanding of the regulation of focal adhesion assembly and force transmission, and the limits to which we can consider focal adhesion plaques as mechanosensitive entities.
authors.affiliation: James Franck Institute, Institute for Biophysical Dynamics and Physics Department, University of Chicago, Chicago, IL, United States.
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Oakes
authors.affiliation: James Franck Institute, Institute for Biophysical Dynamics and Physics Department, University of Chicago, Chicago, IL, United States. Electronic address: gardel@uchicago.edu.
authors.forename: Margaret L
authors.initials: ML
authors.lastname: Gardel
mesh_terms: D001696:Biomechanical Phenomena; D002448:Cell Adhesion / Q000502:physiology; D003599:Cytoskeleton / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D022001:Focal Adhesions / Q000502:physiology; D013312:Stress, Physiological