title: Association of STAT3 common variations with obesity and hypertriglyceridemia: protective and contributive effects.
abstract: Signal transducer and activator of transcription 3 (STAT3) plays an important role in energy metabolism. Here we explore whether STAT3 common variations influence risks of obesity and other metabolic disorders in a Chinese Han population. Two tagging single nucleotide polymorphisms (tagSNPs), rs1053005 and rs957970, were used to capture the common variations of STAT3. Relationships between genotypes and obesity, body mass index, plasma triglyceride and other metabolic diseases related parameters were analyzed for association study in 1742 subjects. Generalized linear model and logistic regression model were used for quantitative data analysis and case-control study, respectively. rs1053005 was significantly associated with body mass index and waist circumference (p=0.013 and p=0.02, respectively). rs957970 was significantly associated with plasma level of triglyceride (p=0.007). GG genotype at rs1053005 had lower risks of both general obesity and central obesity (OR=0.40, p=0.034; OR=0.42, p=0.007, respectively) compared with AA genotype. CT genotype at rs957970 had a higher risk of hypertriglyceridemia (OR=1.43, p=0.015) compared with TT genotype. Neither of the two SNPs was associated with othermetabolic diseases related parameters. Our observations indicated that common variations of STAT3 could significantly affect the risk of obesity and hypertriglyceridemia in Chinese Han population.
authors.affiliation: Department of Occupational Health and Occupational Medicine, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou 510515, China. mazulianghn@gmail.com.
authors.forename: Zuliang
authors.initials: Z
authors.lastname: Ma
authors.affiliation: Department of Occupational Health and Occupational Medicine, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou 510515, China. gongyuan1973@gmail.com.
authors.forename: Guanghai
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Occupational Health and Occupational Medicine, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou 510515, China. chenxuejiaosx@gmail.com.
authors.forename: Xuejiao
authors.initials: X
authors.lastname: Chen
authors.affiliation: Health Management Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. ouzejingd@gmail.com.
authors.forename: Zejin
authors.initials: Z
authors.lastname: Ou
authors.affiliation: Department of Occupational Health and Occupational Medicine, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou 510515, China. zfei@fimmu.edu.cn.
authors.forename: Fei
authors.initials: F
authors.lastname: Zou
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D050796:STAT3 Transcription Factor / Q000235:genetics*
chemical_list: D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human