title: Comparison of ⁶⁸Ga-DOTATOC-PET/CT and PET/MRI hybrid systems in patients with cranial meningioma: Initial results.
abstract: BACKGROUND
  (68)Ga-DOTATOC-PET/CT is a well-established method for detecting and targeting the volume definition of meningiomas prior to radiotherapy. Moreover, there is evidence that this method is able to detect meningiomas with higher sensitivity than the goldstandard MRI. Since the hybrid PET/MRI scanner became available in the past few years, the next stage of development could consequently evolve by evaluating the feasibility of a hybrid PET/MRI scanner using (68)Ga-DOTATOC for detecting meningiomas.
  
  
  METHODS
  Fifteen patients received (68)Ga-DOTATOC-PET/CT (0.5 h post injection [p.i.]) followed by PET/MRI 2 hours p.i. Both investigations were analyzed separately and then compared with respect to image quality, detection of intracranial meningiomas, and radiotracer uptake values (RUVs). In addition, ratios between radiotracer uptake in meningiomas and pituitary glands were compared between both PET/CT and PET/MRI.
  
  
  RESULTS
  Overall, 33 intracranial meningiomas were detected. All were visible with high contrast in both PET/CT and PET/MRI. (68)Ga-DOTATOC-PET/MRI provided flawless image quality without artefacts. Calculated RUV in meningiomas, as well as the ratios of RUVs in meningiomas to those of pituitary glands, were higher in PET/CT. As a result, meningiomas can be distinguished from pituitary glands better in early images.
  
  
  CONCLUSIONS
  (68)Ga-DOTATOC-PET/MRI provided flawless image quality and presented an ideal combination of high sensitivity/specificity (PET) and the best possible morphological visualization of meningiomas (MRI). In addition, excellent detection of meningiomas is already possible at 0.5 hours p.i. Later images do not improve the distinction between pituitary gland and adjacent meningiomas. However, RUVs need to be carefully compared between both imaging modalities.
authors.affiliation: Department of Nuclear Medicine, University Hospital of Heidelberg, Heidelberg, Germany (A.A.-O., C.K., F.L.G., U.H.); Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.A.-O., M.B.W., R.G., M.C.R., H.P.S.); Clinical Cooperation Unit of Nuclear Medicine, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.A.-O., A.D.-S.); Department of Radiation Oncology and Therapy, University Hospital of Heidelberg, Heidelberg, Germany (S.E.C.).
authors.forename: Ali
authors.initials: A
authors.lastname: Afshar-Oromieh
authors.affiliation: Department of Nuclear Medicine, University Hospital of Heidelberg, Heidelberg, Germany (A.A.-O., C.K., F.L.G., U.H.); Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.A.-O., M.B.W., R.G., M.C.R., H.P.S.); Clinical Cooperation Unit of Nuclear Medicine, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.A.-O., A.D.-S.); Department of Radiation Oncology and Therapy, University Hospital of Heidelberg, Heidelberg, Germany (S.E.C.).
authors.forename: Maya B
authors.initials: MB
authors.lastname: Wolf
authors.affiliation: Department of Nuclear Medicine, University Hospital of Heidelberg, Heidelberg, Germany (A.A.-O., C.K., F.L.G., U.H.); Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.A.-O., M.B.W., R.G., M.C.R., H.P.S.); Clinical Cooperation Unit of Nuclear Medicine, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.A.-O., A.D.-S.); Department of Radiation Oncology and Therapy, University Hospital of Heidelberg, Heidelberg, Germany (S.E.C.).
authors.forename: Clemens
authors.initials: C
authors.lastname: Kratochwil
authors.affiliation: Department of Nuclear Medicine, University Hospital of Heidelberg, Heidelberg, Germany (A.A.-O., C.K., F.L.G., U.H.); Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.A.-O., M.B.W., R.G., M.C.R., H.P.S.); Clinical Cooperation Unit of Nuclear Medicine, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.A.-O., A.D.-S.); Department of Radiation Oncology and Therapy, University Hospital of Heidelberg, Heidelberg, Germany (S.E.C.).
authors.forename: Frederik L
authors.initials: FL
authors.lastname: Giesel
authors.affiliation: Department of Nuclear Medicine, University Hospital of Heidelberg, Heidelberg, Germany (A.A.-O., C.K., F.L.G., U.H.); Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.A.-O., M.B.W., R.G., M.C.R., H.P.S.); Clinical Cooperation Unit of Nuclear Medicine, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.A.-O., A.D.-S.); Department of Radiation Oncology and Therapy, University Hospital of Heidelberg, Heidelberg, Germany (S.E.C.).
authors.forename: Stephanie E
authors.initials: SE
authors.lastname: Combs
authors.affiliation: Department of Nuclear Medicine, University Hospital of Heidelberg, Heidelberg, Germany (A.A.-O., C.K., F.L.G., U.H.); Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.A.-O., M.B.W., R.G., M.C.R., H.P.S.); Clinical Cooperation Unit of Nuclear Medicine, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.A.-O., A.D.-S.); Department of Radiation Oncology and Therapy, University Hospital of Heidelberg, Heidelberg, Germany (S.E.C.).
authors.forename: Antonia
authors.initials: A
authors.lastname: Dimitrakopoulou-Strauss
authors.affiliation: Department of Nuclear Medicine, University Hospital of Heidelberg, Heidelberg, Germany (A.A.-O., C.K., F.L.G., U.H.); Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.A.-O., M.B.W., R.G., M.C.R., H.P.S.); Clinical Cooperation Unit of Nuclear Medicine, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.A.-O., A.D.-S.); Department of Radiation Oncology and Therapy, University Hospital of Heidelberg, Heidelberg, Germany (S.E.C.).
authors.forename: Regula
authors.initials: R
authors.lastname: Gnirs
authors.affiliation: Department of Nuclear Medicine, University Hospital of Heidelberg, Heidelberg, Germany (A.A.-O., C.K., F.L.G., U.H.); Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.A.-O., M.B.W., R.G., M.C.R., H.P.S.); Clinical Cooperation Unit of Nuclear Medicine, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.A.-O., A.D.-S.); Department of Radiation Oncology and Therapy, University Hospital of Heidelberg, Heidelberg, Germany (S.E.C.).
authors.forename: Matthias C
authors.initials: MC
authors.lastname: Roethke
authors.affiliation: Department of Nuclear Medicine, University Hospital of Heidelberg, Heidelberg, Germany (A.A.-O., C.K., F.L.G., U.H.); Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.A.-O., M.B.W., R.G., M.C.R., H.P.S.); Clinical Cooperation Unit of Nuclear Medicine, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.A.-O., A.D.-S.); Department of Radiation Oncology and Therapy, University Hospital of Heidelberg, Heidelberg, Germany (S.E.C.).
authors.forename: Heinz P
authors.initials: HP
authors.lastname: Schlemmer
authors.affiliation: Department of Nuclear Medicine, University Hospital of Heidelberg, Heidelberg, Germany (A.A.-O., C.K., F.L.G., U.H.); Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.A.-O., M.B.W., R.G., M.C.R., H.P.S.); Clinical Cooperation Unit of Nuclear Medicine, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.A.-O., A.D.-S.); Department of Radiation Oncology and Therapy, University Hospital of Heidelberg, Heidelberg, Germany (S.E.C.).
authors.forename: Uwe
authors.initials: U
authors.lastname: Haberkorn
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D003287:Contrast Media; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods*; D015282:Octreotide / Q000031:analogs & derivatives; D009942:Organometallic Compounds; D049268:Positron-Emission Tomography / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D003287:Contrast Media; C499142:Ga(III)-DOTATOC; D009942:Organometallic Compounds; D015282:Octreotide
keywords: 68Ga-DOTATOC; MRI; PET/CT; PET/MRI; hybrid imaging; meningioma; somatostatin receptor