title: Changes in neural stem cells in the subventricular zone in a rat model of communicating hydrocephalus.
abstract: Communicating hydrocephalus is a common type of hydrocephalus. At present, the prevalent treatment is to perform a ventriculo-peritoneal shunt, which, for reasons that are not clear, is sometimes ineffective. The subventricular zone (SVZ) of the lateral ventricles has been established as the primary site of adult neurogenesis. Following cerebral ischemia or brain injury, neural stem cells (NSCs) increase in the SVZ and can both differentiate into neurons and glial cells and respond to the injury. Neural stem cells, enabled by a complex repertoire of factors that precisely regulate the activation, proliferation, differentiation and integration of newborn cells, continuously generate new neurons. However, only a few systematic studies of the role of NSCs in hydrocephalus have been reported. In a rat model of communicating hydrocephalus, we recently showed that hydrocephalus caused the ventricular system to expand over time. We found that the number of NSCs in the SVZ peaked rapidly after hydrocephalus was established and decreased gradually over time until the cells disappeared. NSCs may be involved in the pathophysiology changes and repair process of hydrocephalus.
authors.affiliation: Department of Neurosurgery, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Radiologists, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
authors.forename: Dongxue
authors.initials: D
authors.lastname: Wu
authors.affiliation: Department of Neurosurgery, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China. Electronic address: dlluckywcm@163.com.
authors.forename: Chunming
authors.initials: C
authors.lastname: Wu
authors.affiliation: Department of Pathophysiology, Dalian Medical University, Dalian, Liaoning, China.
authors.forename: Zhenyun
authors.initials: Z
authors.lastname: Qu
authors.affiliation: Department of Neurosurgery, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
authors.forename: Yongshun
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Neurosurgery, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
authors.forename: Weihua
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
authors.forename: Zhongmin
authors.initials: Z
authors.lastname: Li
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D004195:Disease Models, Animal; D005260:Female; D006849:Hydrocephalus / Q000503:physiopathology*; D020547:Lateral Ventricles / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D058953:Neural Stem Cells / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
keywords: Communicating hydrocephalus; Neural stem cells; Rats; Shunt; Ventricular-subventricular zone