title: Synthesis of 1-[bis(trifluoromethyl)phosphine]-1'-oxazolinylferrocene ligands and their application in regio- and enantioselective Pd-catalyzed allylic alkylation of monosubstituted allyl substrates.
abstract: A class of novel, easily accessible and air-stable 1-[bis(trifluoromethyl)phosphine]-1'-oxazolinylferrocene ligands has been synthesized from ferrocene. It became apparent that these ligands can be used in the regio- and enantioselective Pd-catalyzed allylic alkylation of monosubstituted allyl substrates in a highly efficient manner. Excellent regio- and enantioselectivity could be obtained for a wide range of substrates.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China ; State Key Laboratory of Natural Medicines and Center of Drug Discovery, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing 210009, China.
authors.forename: Zeng-Wei
authors.initials: ZW
authors.lastname: Lai
authors.affiliation: Process Development and Manufacturing Department, Pharmaron (Beijing) Co. Ltd, 6 Taihe Road, BDA, Beijing, 100176, China.
authors.forename: Rong-Fei
authors.initials: RF
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.
authors.forename: Ke-Yin
authors.initials: KY
authors.lastname: Ye
authors.affiliation: State Key Laboratory of Natural Medicines and Center of Drug Discovery, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing 210009, China.
authors.forename: Hongbin
authors.initials: H
authors.lastname: Sun
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.
authors.forename: Shu-Li
authors.initials: SL
authors.lastname: You
keywords: allylic substitution; enantioselectivity; ferrocene; organophosphorus; palladium; regioselectivity