title: PPI therapy. The small bowel, low-dose aspirin and PPIs--should we be concerned?
abstract: A new study suggests that co-prescription of low-dose aspirin and PPIs increases the incidence of small-bowel mucosal breaks. Should we be concerned about the potential negative interactions of these drugs? Or is the balance of evidence still substantially tipped towards the need for PPIs to protect against aspirin-induced upper gastrointestinal damage?
authors.affiliation: University Clinic Hospital, University of Zaragoza, CIBERehd, IIS Aragón, Calle de San Juan Bosco 15, 5009 Zaragoza, Spain.
authors.forename: Angel
authors.initials: A
authors.lastname: Lanas
authors.affiliation: University Clinic Hospital, University of Zaragoza, CIBERehd, IIS Aragón, Calle de San Juan Bosco 15, 5009 Zaragoza, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Sostres
mesh_terms: D001241:Aspirin / Q000008:administration & dosage* / Q000009:adverse effects*; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects; D007421:Intestine, Small / Q000187:drug effects*; D054328:Proton Pump Inhibitors / Q000008:administration & dosage*
chemical_list: D054328:Proton Pump Inhibitors; D001241:Aspirin