title: Scaffolding builds to reduce blood pressure.
abstract: Endothelial cells provide vasodilator signals to reduce blood pressure. In the small resistance arteries and arterioles, which determine the distribution and pressure of blood, the major signal is hyperpolarization reflecting the endothelial activity of calcium-activated potassium channels (KCa). In this issue of Science Signaling, Sonkusare et al. report that the scaffold protein AKAP150 is required for the kinase PKC and the calcium channel TRPV4 to enable receptor-mediated relaxation signaling. This scaffold enhances TRPV4 gating cooperativity and markedly amplifies the Ca(2+) signal, which ultimately activates (mainly) IKCa channels. Normally restricted to tiny endothelial projections, AKAP150 localization and associated signaling is disrupted in a model of hypertension, thereby diminishing hyperpolarization and vasodilation.
authors.affiliation: Department of Pharmacology, University of Oxford, Oxford OX1 3QT, UK.
authors.forename: Pooneh
authors.initials: P
authors.lastname: Bagher
authors.affiliation: Department of Pharmacology, University of Oxford, Oxford OX1 3QT, UK christopher.garland@pharm.ox.ac.uk.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Garland
mesh_terms: D054758:A Kinase Anchor Proteins / Q000378:metabolism*; D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D020013:Calcium Signaling / Q000502:physiology*; D042783:Endothelial Cells / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D050916:TRPV Cation Channels / Q000378:metabolism*; D014664:Vasodilation / Q000502:physiology*
chemical_list: D054758:A Kinase Anchor Proteins; D050916:TRPV Cation Channels; C416986:TRPV4 protein, human