title: Long-term complete remission of multiple extranodal natural killer/T-cell-type posttransplant lymphoproliferative disorder after surgical resection: a case report.
abstract: BACKGROUND
  Posttransplant lymphoproliferative disorder (PTLD) is a life-threatening complication of organ transplantation that results from immunosuppression therapy. Most cases of PTLD derive from the B-cell lineage. T-cell PTLD, particularly natural killer (NK)/T-cell PTLD, is quite rare; only a few cases have been described.
  
  
  METHODS
  A 42-year-old woman received a living-related renal allograft from her father. Sixteen years after transplantation, the patient presented with a 1-week history of low-grade fever and epigastralgia. Computed tomography revealed intestinal masses and a right upper lung lobe mass. Gallium scintigraphy showed uptake in the abdominal mass. Epstein-Barr virus-related antibody was not detected in the patient's serum sample. We performed extirpation of the jejunum and ileum tumors. The pathologic findings showed that these 2 tumors were NK/T-cell lymphoma. After the operation, the lung mass rapidly enlarged, and right upper lobectomy was performed. The right upper lung lobe tumor showed the same histopathologic findings as the small bowel tumor. The final histologic diagnosis was established as multiple extranodal NK/T cell type PTLD of the small bowel and right upper lung lobe.
  
  
  CONCLUSIONS
  After reduction of the immunosuppressive agent, no recurrence of PTLD has been observed for the past 9 years.
authors.affiliation: Division of Surgery, Hachinohe City Hospital, Japan. Electronic address: matsumuramuneyuki@yahoo.co.jp.
authors.forename: M
authors.initials: M
authors.lastname: Matsumura
authors.affiliation: Division of Surgery, Hachinohe City Hospital, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Mizuno
authors.affiliation: Division of Surgery, Hachinohe City Hospital, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Okamoto
authors.affiliation: Division of Surgery, Hachinohe City Hospital, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Sawa
authors.affiliation: Division of Pathology, Hachinohe City Hospital, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Katayama
authors.affiliation: Division of Pathology, Hakodate Municipal Hospital, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Shimoyama
authors.affiliation: Division of Advanced Surgical Science and Technology, Graduate School of Medicine, Tohoku University, Miyagi, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Kawagishi
authors.affiliation: Division of Surgery, Hachinohe City Hospital, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Miura
mesh_terms: D000328:Adult; D001402:B-Lymphocytes / Q000473:pathology; D005260:Female; D006801:Humans; D007078:Ileal Neoplasms / Q000150:complications / Q000473:pathology; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007580:Jejunal Neoplasms / Q000150:complications / Q000473:pathology; D016030:Kidney Transplantation; D008175:Lung Neoplasms / Q000150:complications / Q000473:pathology; D054391:Lymphoma, Extranodal NK-T-Cell / Q000150:complications*; D008232:Lymphoproliferative Disorders / Q000139:chemically induced*; D012074:Remission Induction; D014057:Tomography, X-Ray Computed
chemical_list: D007166:Immunosuppressive Agents