title: Cerebral vasospasm.
abstract: Cerebral vasospasm causes delayed ischemic neurologic deficits after aneurysmal subarachnoid hemorrhage. This is a well-established clinical entity with significant associated morbidity and mortality. The underlying patholphysiology is highly complex and poorly understood. Large-vessel vasospasm, autoregulatory dysfunction, inflammation, genetic predispositions, microcirculatory failure, and spreading cortical depolarization are aspects of delayed neurologic deterioration that have been described in the literature. This article presents a perspective on cerebral vasospasm, as guided by the literature to date, specifically examining the mechanism, diagnosis, and treatment of cerebral vasospasm.
authors.affiliation: Department of Neurological Surgery, University of Wisconsin Hospital and Clinics, 600 Highland Avenue, Madison, WI 53792, USA.
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Baggott
authors.affiliation: Neuroendovascular Fellowship: Endovascular Neurosurgery/Neurointerventional Surgery, Neuroendovascular Section, University of Wisconsin Hospital and Clinics, 600 Highland Avenue, Madison, WI 53792, USA. Electronic address: BAagaard-Kienitz@uwhealth.org.
authors.forename: Beverley
authors.initials: B
authors.lastname: Aagaard-Kienitz
mesh_terms: D057510:Endovascular Procedures; D006801:Humans; D007249:Inflammation; D013345:Subarachnoid Hemorrhage / Q000150:complications; D014665:Vasodilator Agents / Q000627:therapeutic use*; D020301:Vasospasm, Intracranial / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism / Q000628:therapy*
chemical_list: D014665:Vasodilator Agents
keywords: Cerebral vasospasm; Delayed ischemic neurologic injury; Neurologic deficits; Subarachnoid hemorrhage