title: [Features of asthma in women: what is the relationship with hormonal status?].
abstract: BACKGROUND
  The prevalence and control of asthma are modulated by hormonal changes in women, suggesting an influence of sex hormones on the airways.
  
  
  BACKGROUND
  The blood levels of both oestrogens and progesterone can modulate airway tone and inflammation. Asthma prevalence changes at puberty and the menopause, events also associated with modifications of adipose tissue and behaviour. Changes in lung function and asthma control are well documented during the menstrual cycle. However, an effect of hormone therapy on asthma control has not been demonstrated.
  
  
  CONCLUSIONS
  The effect of a targeted hormonal therapeutic intervention in menopausal asthma, a phenotype, which is frequently particularly severe, or in premenstrual asthma, should be evaluated by randomized trials.
  
  
  CONCLUSIONS
  Involvement of sex hormones and their cyclical variations in the characteristics of asthma in women is probable, despite lack of convincing data. However, no definitive protective or deleterious effect can be assigned. Complex interactions with adipose tissue, airways anatomy and the domestic or working environment must be taken into account to explain these differences.
authors.affiliation: Inserm U700, service de pneumologie, département hospitalo-universitaire FIRE, centre de compétence des maladies pulmonaires rares, hôpital Bichat, université Paris Diderot, AP-HP, 46, rue Henri-Huchard, 75877 Paris cedex, France. Electronic address: camille.taille@bch.aphp.fr.
authors.forename: C
authors.initials: C
authors.lastname: Taillé
authors.affiliation: U897 ISPED, service des maladies respiratoires, CHU de Bordeaux, université Bordeaux Segalen, 33076 Bordeaux, France.
authors.forename: C
authors.initials: C
authors.lastname: Raherison
authors.affiliation: Service de médecine du travail et pathologies professionnelles, CHRU de Lille, 59000 Lille, France.
authors.forename: A
authors.initials: A
authors.lastname: Sobaszek
authors.affiliation: Unité de pneumologie pédiatrique, hôpital Jeanne-de-Flandre, CHRU de Lille, 59000 Lille, France.
authors.forename: C
authors.initials: C
authors.lastname: Thumerelle
authors.affiliation: Service de pneumologie, CHG de Bigorre, 65000 Tarbes, France.
authors.forename: A
authors.initials: A
authors.lastname: Prudhomme
authors.affiliation: Hôpital privé Jean-Mermoz, 69008 Lyon, France.
authors.forename: E
authors.initials: E
authors.lastname: Biron
authors.affiliation: Service de pneumologie, centre hospitalier de la Côte Basque, 64100 Bayonne, France.
authors.forename: C
authors.initials: C
authors.lastname: Nocent
authors.affiliation: Inserm U1019, service de pneumologie et d'immuno-allergologie, institut Pasteur de Lille, hôpital Calmette, université de Lille-2, CHRU, 59000 Lille, France.
authors.forename: I
authors.initials: I
authors.lastname: Tillie-Leblond
mesh_terms: D001249:Asthma / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood* / Q000494:pharmacology; D006801:Humans; D012143:Respiratory Physiological Phenomena / Q000187:drug effects; D012137:Respiratory System / Q000187:drug effects / Q000503:physiopathology; D012307:Risk Factors; D012720:Severity of Illness Index; D012737:Sex Factors
chemical_list: D012739:Gonadal Steroid Hormones
keywords: Asthma; Asthme; Asthme prémenstruel; Femme; Grossesse; Hormones sexuelles; Pregnancy; Premenstrual asthma; Sex hormones; Women