title: Endovascular coil embolization of aneurysm neck for the treatment of ruptured intracranial aneurysm with bleb formation.
abstract: BACKGROUND
  Ruptured intracranial aneurysm (ICA) with bleb formation (RICABF) is a special type of ruptured ICA. However, the exact role and effectiveness of endovascular coil embolization (ECE) in RICABF is unknown. We aimed to investigate the effectiveness and safety of ECE of aneurysm neck for RICABF treatment.
  
  
  METHODS
  We retrospectively assessed consecutive patients who were hospitalized in our endovascular intervention center between October 2004 and May 2012. Overall, 86 patients underwent ECE of aneurysm neck for 86 RICABF. Treatments outcomes included secondary rupture/bleeding rate, aneurysm neck embolization rate, residual/recurrent aneurysm, intraoperative incidents, and post-embolization complications, as well as improvements in the Glasgow outcome scale (extended) (GOS-E).
  
  
  RESULTS
  Complete occlusion was achieved in 72 aneurysms (72/86, 83.7%), while 12 aneurysms (12/86, 14.0%) had a residual neck, and 2 aneurysms (2/86, 2.3%) had a residual aneurysm. The postoperative GOS-E was 3 in 3 patients (3.5%), 4 in 10 patients (11.6%), and 5 in 73 patients (84.9%). Follow-up angiography was performed in all patients (mean 9.0 months, interquartile range of 9.0). Recurrence was found in 3 patients (3/86, 3.5%). No aneurysm rupture or bleeding was reported.
  
  
  CONCLUSIONS
  Our mid-term follow-up study showed that ECE of aneurysm neck was an effective and safe treatment modality for RICABF. The long-term effectiveness and safety of this interventional radiology technique need to be investigated in prospective and comparative studies.
authors.affiliation: Department of Radiology, Jing'an District Centre Hospital of Shanghai Huashan Hospital Fudan University Jing'an Branch, Shanghai, China (mainland).
authors.forename: Jun
authors.initials: J
authors.lastname: Wan
authors.affiliation: Department of Radiology, Jing'an District Centre Hospital of Shanghai Huashan Hospital Fudan University Jing'an Branch, Shanghai, China (mainland).
authors.forename: Weijin
authors.initials: W
authors.lastname: Gu
authors.affiliation: Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China (mainland).
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China (mainland).
authors.forename: Daoying
authors.initials: D
authors.lastname: Geng
authors.affiliation: Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China (mainland).
authors.forename: Gang
authors.initials: G
authors.lastname: Lu
authors.affiliation: Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China (mainland).
authors.forename: Lei
authors.initials: L
authors.lastname: Huang
authors.affiliation: Department of Radiology, Jing'an District Centre Hospital of Shanghai Huashan Hospital Fudan University Jing'an Branch, Shanghai, China (mainland).
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China (mainland).
authors.forename: Liang
authors.initials: L
authors.lastname: Ge
authors.affiliation: Department of Radiology, Jing'an District Centre Hospital of Shanghai Huashan Hospital Fudan University Jing'an Branch, Shanghai, China (mainland).
authors.forename: Lihua
authors.initials: L
authors.lastname: Ji
mesh_terms: D000328:Adult; D017542:Aneurysm, Ruptured / Q000150:complications* / Q000000981:diagnostic imaging / Q000628:therapy*; D001768:Blister / Q000150:complications* / Q000000981:diagnostic imaging; D004621:Embolization, Therapeutic / Q000009:adverse effects; D057510:Endovascular Procedures / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications* / Q000000981:diagnostic imaging / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology; D013345:Subarachnoid Hemorrhage / Q000150:complications / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome