title: [Effect of atorvastatin on exercise tolerance in patients with diastolic dysfunction and exercise-induced hypertension].
abstract: To investigate the effect of atorvastatin on exercise tolerance in patients with diastolic dysfunction and exercise-induced hypertension.
  
  
  
  A randomized, double-blind, placebo-controlled prospective study was performed. Sixty patients with diastolic dysfunction (mitral flow velocity E/A <1) and exercise-induced hypertension (SBP>200 mm Hg) treated with atorvastatin (20 mg q.d) or placebo for 1 year. Cardiopulmonary exercise test and exercise blood pressure measurement were performed. Plasma B-natriuretic peptide (BNP) concentration at rest and at peak exercise, plasma high sensitive-C reaction protein (hs-CRP) and endothelin (ET) concentration were determined at baseline and after treatment.
  
  
  
  After treatment by atorvastatin, the resting SBP, pulse pressure, the peak exercise SBP and BNP were significantly decreased; and the exercise time, metabolic equivalent, maximal oxygen uptake and anaerobic threshold were increased. All of these parameters had significant differences with baseline levels (P<0.05) and the rest pulse pressure, the peak exercise SBP and BNP, and the exercise time had significant differences compared with placebo treatment (P<0.05). Plasma concentrations of hs-CRP and ET were markedly reduced by atorvastatin treatment compared with baseline and placebo (P<0.05). No difference in above parameters was found before and after placebo treatment (P>0.05).
  
  
  
  In patients with diastolic dysfunction at rest and exercise-induced hypertension, atorvastatin can effectively reduce plasma hs-CRP and ET level, lower blood pressure and peak exercise SBP, decrease peak exercise plasma BNP concentration, and ultimately improve exercise tolerance.
authors.affiliation: Department of Cardiology， Zhejiang Jinhua Guangfu Hospotal， Jinhua 321000， China.
authors.forename: Ping-xian
authors.initials: PX
authors.lastname: Ye
authors.affiliation: Department of Cardiology， Zhejiang Jinhua Guangfu Hospotal， Jinhua 321000， China.
authors.forename: Ping-zhen
authors.initials: PZ
authors.lastname: Ye
authors.affiliation: Department of Cardiology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310006,China.
authors.forename: Jian-hua
authors.initials: JH
authors.lastname: Zhu
authors.affiliation: Department of Cardiology， Zhejiang Jinhua Guangfu Hospotal， Jinhua 321000， China.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Cardiology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310006,China.
authors.forename: Dan-chen
authors.initials: DC
authors.lastname: Gao
mesh_terms: D000368:Aged; D000069059:Atorvastatin; D002097:C-Reactive Protein / Q000378:metabolism; D004311:Double-Blind Method; D016232:Endothelins / Q000097:blood; D017079:Exercise Tolerance / Q000187:drug effects*; D005260:Female; D006333:Heart Failure / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D006538:Heptanoic Acids / Q000494:pharmacology*; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D011446:Prospective Studies; D011758:Pyrroles / Q000494:pharmacology*
chemical_list: D016232:Endothelins; D006538:Heptanoic Acids; D011758:Pyrroles; D020097:Natriuretic Peptide, Brain; D002097:C-Reactive Protein; D000069059:Atorvastatin