title: Altered intrinsic hippocmapus declarative memory network and its association with impulsivity in abstinent heroin dependent subjects.
abstract: Converging evidence suggests that addiction can be considered a disease of aberrant learning and memory with impulsive decision-making. In the past decades, numerous studies have demonstrated that drug addiction is involved in multiple memory systems such as classical conditioned drug memory, instrumental learning memory and the habitual learning memory. However, most of these studies have focused on the contributions of non-declarative memory, and declarative memory has largely been neglected in the research of addiction. Based on a recent finding that hippocampus, as a core functioning region of declarative memory, was proved biased the decision-making process based on past experiences by spreading associated reward values throughout memory. Our present study focused on the hippocampus. By utilizing seed-based network analysis on the resting-state functional MRI datasets with the seed hippocampus we tested how the intrinsic hippocampal memory network altered toward drug addiction, and examined how the functional connectivity strength within the altered hippocampal network correlated with behavioral index 'impulsivity'. Our results demonstrated that HD group showed enhanced coherence between hippocampus which represents declarative memory system and non-declarative reward-guided learning memory system, and also showed attenuated intrinsic functional link between hippocampus and top-down control system, compared to the CN group. This alteration was furthered found to have behavioral significance over the behavioral index 'impulsivity' measured with Barratt Impulsiveness Scale (BIS). These results provide insights into the mechanism of declarative memory underlying the impulsive behavior in drug addiction.
authors.affiliation: Department of Biomedical Engineering, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, PR China; Cognitive and Mental Health Research Center, Beijing Institute of Basic Medical Science, Beijing, PR China; Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA.
authors.forename: Tian-Ye
authors.initials: TY
authors.lastname: Zhai
authors.affiliation: Cognitive and Mental Health Research Center, Beijing Institute of Basic Medical Science, Beijing, PR China. Electronic address: budeshao@aliyun.com.
authors.forename: Yong-Cong
authors.initials: YC
authors.lastname: Shao
authors.affiliation: Cognitive and Mental Health Research Center, Beijing Institute of Basic Medical Science, Beijing, PR China; Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA.
authors.forename: Chun-Ming
authors.initials: CM
authors.lastname: Xie
authors.affiliation: Cognitive and Mental Health Research Center, Beijing Institute of Basic Medical Science, Beijing, PR China.
authors.forename: En-Mao
authors.initials: EM
authors.lastname: Ye
authors.affiliation: Cognitive and Mental Health Research Center, Beijing Institute of Basic Medical Science, Beijing, PR China.
authors.forename: Feng
authors.initials: F
authors.lastname: Zou
authors.affiliation: Cognitive and Mental Health Research Center, Beijing Institute of Basic Medical Science, Beijing, PR China.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Fu
authors.affiliation: Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA.
authors.forename: Wen-Jun
authors.initials: WJ
authors.lastname: Li
authors.affiliation: Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA.
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.affiliation: Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA.
authors.forename: Guang-Yu
authors.initials: GY
authors.lastname: Chen
authors.affiliation: Department of Biomedical Engineering, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, PR China. Electronic address: zhangzg126@126.com.
authors.forename: Zheng-Guo
authors.initials: ZG
authors.lastname: Zhang
authors.affiliation: Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address: sjli@mcw.edu.
authors.forename: Shi-Jiang
authors.initials: SJ
authors.lastname: Li
authors.affiliation: Cognitive and Mental Health Research Center, Beijing Institute of Basic Medical Science, Beijing, PR China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Yang
mesh_terms: D000328:Adult; D001931:Brain Mapping; D006556:Heroin Dependence / Q000503:physiopathology*; D006624:Hippocampus / Q000503:physiopathology*; D006801:Humans; D007175:Impulsive Behavior / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D009434:Neural Pathways / Q000503:physiopathology; D011594:Psychometrics; D012146:Rest
keywords: Decision-making; Declarative memory; Drug addiction; Functional connectivity; Hippocampus; Impulsivity