title: Neuropeptide NGF mediates neuro-immune response and inflammation through mast cell activation.
abstract: Human mast cells (first described in 1879 by Paul Ehrlich) develop from committed precursors in the bone marrow expressing the differentiation marker CD34+ and distinct from the three other myeloid cells. Mast cells are present in various tissues especially near blood vessels, epithelia and nerves and they are activated by cross-linking of Fc&#949;RI, but also by a number of neuropeptides. NGF mediates a number of inflammatory and autoimmune states in conjunction with an increased accumulation of mast cells which appear to be involved in neuroimmune interactions and tissue inflammation. Here we report some relationships between mast cells and nerve growth factor (NGF).
authors.affiliation: Department of Microbiology and Infectious Diseases, School of Veterinary Medicine, Aristotle University of Thessaloniki, Macedonia, Greece.
authors.forename: S K
authors.initials: SK
authors.lastname: Kritas
authors.affiliation: Department of Dermatology, University of Rome Tor Vergata, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Saggini
authors.affiliation: Nicolas Foundation, Onlus, Arezzo, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Cerulli
authors.affiliation: Orthopedic Division, University of Perugia, Perugia, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Caraffa
authors.affiliation: Orthopedic Division, University of Perugia, Perugia, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Antinolfi
authors.affiliation: Orthopedic Division, University of Chieti-Pescara, Chieti, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Pantalone
authors.affiliation: Department of Parasitology, School of Veterinary Medicine, University of Thessaloniki, Macedonia, Greece.
authors.forename: S
authors.initials: S
authors.lastname: Frydas
authors.affiliation: Gynecology Clinic, Pescara Hospital, Pescara, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Rosati
authors.affiliation: Nicolas Foundation, Onlus, Arezzo, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Tei
authors.affiliation: Nicolas Foundation, Onlus, Arezzo, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Speziali
authors.affiliation: Department of Neurosciences and Imaging, Faculty of Medicine and Surgery, G. dAnnunzio University Chieti-Pescara, Chieti, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Saggini
authors.affiliation: Department of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Pandolfi
authors.affiliation: Immunology Division, Medical School, University of Chieti-Pescara, Chieti, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Conti
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D008407:Mast Cells / Q000276:immunology* / Q000473:pathology; D020932:Nerve Growth Factor / Q000276:immunology*; D017455:Receptors, IgE / Q000276:immunology
chemical_list: D017455:Receptors, IgE; D020932:Nerve Growth Factor