title: Stereoselective synthesis of cis-2-fluorocyclopropanecarboxylic acid.
abstract: A rhodium-catalyzed cyclopropanation of 1-fluoro-1-(phenylsulfonyl)ethylene and diazo esters is described as an effective method for the stereoselective synthesis of cis-2-fluorocyclopropanecarboxylic acid. This process provides an example of the cyclopropanation of electron-deficient olefin and diazoacetates.
authors.affiliation: Discovery Research Laboratories, Kyorin Pharmaceutical Co., Ltd. , 2399-1, Nogi, Nogi-Machi, Shimotsuga-Gun, Tochigi, 329-0114, Japan.
authors.forename: Taku
authors.initials: T
authors.lastname: Shibue
authors.forename: Yasumichi
authors.initials: Y
authors.lastname: Fukuda
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D001391:Azo Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D003521:Cyclopropanes / Q000138:chemical synthesis* / Q000737:chemistry; D005030:Ethylenes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: C000595037:1-fluoro-1-(phenylsulfonyl)ethylene; D000475:Alkenes; D001391:Azo Compounds; D003521:Cyclopropanes; D005030:Ethylenes; D013438:Sulfhydryl Compounds; C000595038:cis-2-fluorocyclopropanecarboxylic acid