title: Assessment of the effect of intraarticular injection of autologous adipose-derived mesenchymal stem cells in osteoarthritic dogs using a double blinded force platform analysis.
abstract: BACKGROUND
  Regenerative medicine using Mesenchymal Stem Cells (MSC) alone or combined with Plasma Rich in Growth Factors (PRGF) is a rapidly growing area of clinical research and is currently also being used to treat osteoarthritis (OA). Force platform analysis has been consistently used to verify and quantify the efficacy of different therapeutic strategies for the treatment of OA in dogs including MSC associated to PRGF, but never with AD-MSC alone. The aim of this study was to use a force platform to measure the efficacy of intraarticular ADMSC administration for limb function improvement in dogs with severe OA.
  
  
  RESULTS
  Ten lame dogs with severe hip OA and a control group of 5 sound dogs were used for this study. Results were statistically analyzed to detect a significant increase in peak vertical force (PVF) and vertical impulse (VI) in treated dogs. Mean values of PVF and VI were significantly improved within the first three months post-treatment in the OA group, increasing 9% and 2.5% body weight, respectively, at day 30. After this, the effect seems to decrease reaching initial values.
  
  
  CONCLUSIONS
  Intraarticular ADMSC therapy objectively improved limb function in dogs with hip OA. The duration of maximal effect was less than 3 months.
authors.affiliation: Department of Animal Pathology, Faculty of Veterinary Medicine, Universidad de Las Palmas de Gran Canaria, Trasmontaña S/N, Arucas, 35413 Las Palmas, Spain. jvilar@dpat.ulpgc.es.
authors.forename: Jose M
authors.initials: JM
authors.lastname: Vilar
authors.forename: Miguel
authors.initials: M
authors.lastname: Batista
authors.forename: Manuel
authors.initials: M
authors.lastname: Morales
authors.forename: Angelo
authors.initials: A
authors.lastname: Santana
authors.forename: Belén
authors.initials: B
authors.lastname: Cuervo
authors.forename: Mónica
authors.initials: M
authors.lastname: Rubio
authors.forename: Ramón
authors.initials: R
authors.lastname: Cugat
authors.forename: Joaquín
authors.initials: J
authors.lastname: Sopena
authors.forename: Jose M
authors.initials: JM
authors.lastname: Carrillo
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D000818:Animals; D016022:Case-Control Studies; D004283:Dog Diseases / Q000628:therapy*; D004285:Dogs; D004311:Double-Blind Method; D005260:Female; D005684:Gait; D007270:Injections, Intra-Articular / Q000662:veterinary; D007794:Lameness, Animal; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000662:veterinary*; D010003:Osteoarthritis / Q000628:therapy / Q000662:veterinary*; D016474:Weight-Bearing / Q000502:physiology