title: A meta-analysis of the association between p53 codon 72 polymorphism and susceptibility to endometriosis.
abstract: OBJECTIVE
  The aim of this study was to determine whether the p53 codon 72 polymorphism is associated with susceptibility to endometriosis.
  
  
  METHODS
  A meta-analysis was conducted on the associations between the p53 codon 72 polymorphism and endometriosis using 1) allele contrast, 2) a recessive model, 3) a dominant model, and 4) homozygote contrast.
  
  
  RESULTS
  Nine studies involving 1,803 patients and 2,006 controls were considered in the meta-analysis. Meta-analysis of the p53 polymorphism showed no association between endometriosis and the p53 C allele (odds ratio (OR) = 1.087, 95% confidence interval (CI) = 0.921-1.282, p = 0.323). Stratification by ethnicity indicated no association between the p53 C allele and endometriosis in Europeans and Latin Americans. However, a significant association was found between the p53 C allele and endometriosis in East Asians (OR = 1.405, 95% CI = 1.065-1.854, p = 0.016). Furthermore, association was found between the p53 polymorphism and endometriosis in East Asians using the dominant model (OR = 2.046, 95% CI = 1.123-3.730, p = 0.019).
  
  
  CONCLUSIONS
  This meta-analysis demonstrates that the p53 codon 72 polymorphism may be associated with susceptibility to endometriosis in East Asians, but not in Europeans and Latin Americans.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine , Seoul , Korea.
authors.forename: Gwan Gyu
authors.initials: GG
authors.lastname: Song
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Lee
mesh_terms: D000483:Alleles; D003062:Codon / Q000235:genetics; D004715:Endometriosis / Q000235:genetics*; D005006:Ethnicity; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D003062:Codon; D016159:Tumor Suppressor Protein p53
keywords: Endometriosis; meta-analysis; p53; polymorphism