title: Polyglycolic acid sheet with fibrin glue potentiates the effect of a fibrin-based haemostat in cardiac surgery.
abstract: BACKGROUND
  Hemorrhage from the left ventricle can be critical and sutureless repair using a fibrin-based haemostat (TachoComb) is one effective option. When active hemorrhage is not controlled by the haemostat, we have used a polyglycolic acid (PGA) sheet and fibrin glue in addition. Here we investigated whether the PGA sheet and fibrin glue combined with TachoComb had stronger adhesive properties than TachoComb alone in two experimental models.
  
  
  METHODS
  Experiment 1. An airtight circuit that included rabbit skin with holes covered by each type of sealant was gradually pressurized and the burst pressure was recorded automatically (n = 10). Experiment 2. A suture loop was attached to a porcine heart by each sealant, and the peel-off pressure was measured (n = 12).
  
  
  RESULTS
  The PGA sheet and fibrin glue combined with TachoComb showed significantly higher adhesive strength than TachoComb alone in both experiments (p < 0.05).
  
  
  CONCLUSIONS
  Adding a PGA sheet and fibrin glue increased the adhesive strength of TachoComb in two experimental models, suggesting that this method might be effective for achieving haemostasis in difficult clinical situations.
authors.affiliation: Department of Cardiovascular Surgery, National Hospital Organization Saitama Hospital, 2-1 Suwa, Wako 351-0102, Japan. kasa7777@gmail.com.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Kasahara
authors.forename: Ichiro
authors.initials: I
authors.lastname: Hayashi
mesh_terms: D000818:Animals; D007611:Aprotinin / Q000627:therapeutic use*; D006348:Cardiac Surgical Procedures; D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use; D005340:Fibrinogen / Q000627:therapeutic use*; D006488:Hemostasis, Surgical / Q000379:methods*; D023421:Models, Animal; D011100:Polyglycolic Acid / Q000627:therapeutic use*; D011817:Rabbits; D013526:Surgical Mesh; D013552:Swine; D013917:Thrombin / Q000627:therapeutic use*; D014014:Tissue Adhesives / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives; C093991:tachocomb; D011100:Polyglycolic Acid; D005340:Fibrinogen; D007611:Aprotinin; D013917:Thrombin