title: A Chinese herbal medicine, jia-wei-xiao-yao-san, prevents dimethylnitrosamine-induced hepatic fibrosis in rats.
abstract: Jia-wei-xiao-yao-san (JWXYS) is a traditional Chinese herbal medicine that is widely used to treat neuropsychological disorders. Only a few of the hepatoprotective effects of JWXYS have been studied. The aim of this study was to investigate the hepatoprotective effects of JWXYS on dimethylnitrosamine- (DMN-) induced chronic hepatitis and hepatic fibrosis in rats and to clarify the mechanism through which JWXYS exerts these effects. After the rats were treated with DMN for 3 weeks, serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) levels were significantly elevated, whereas the albumin level decreased. Although DMN was continually administered, after the 3 doses of JWXYS were orally administered, the SGOT and SGPT levels significantly decreased and the albumin level was significantly elevated. In addition, JWXYS treatment prevented liver fibrosis induced by DMN. JWXYS exhibited superoxide-dismutase-like activity and dose-dependently inhibited DMN-induced lipid peroxidation and xanthine oxidase activity in the liver of rats. Our findings suggest that JWXYS exerts antifibrotic effects against DMN-induced chronic hepatic injury. The possible mechanism is at least partially attributable to the ability of JWXYS to inhibit reactive-oxygen-species-induced membrane lipid peroxidation.
authors.affiliation: Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, No. 250, Wuxing Street, Xinyi District, Taipei 110, Taiwan ; Department of Pharmacy, Taipei Medical University Hospital, No. 252, Wuxing Street, Xinyi District, Taipei 110, Taiwan.
authors.forename: Shu-Chen
authors.initials: SC
authors.lastname: Chien
authors.affiliation: Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, No. 250, Wuxing Street, Xinyi District, Taipei 110, Taiwan ; Department of Pharmacy, Taipei Medical University-Wan Fang Hospital, No. 111, Section 3, Xinglong Road, Wenshan District, Taipei 116, Taiwan ; Master Program for Clinical Pharmacogenomics and Pharmacoproteomics, School of Pharmacy, Taipei Medical University, No. 250, Wuxing Street, Xinyi District, Taipei 110, Taiwan ; Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, No. 100, Shiquan 1st Road, Sanmin District, Kaohsiung 807, Taiwan ; Cancer Center, Kaohsiung Medical University Hospital, No. 100, Tzyou 1st Road, Kaohsiung 807, Taiwan.
authors.forename: Wei-Chiao
authors.initials: WC
authors.lastname: Chang
authors.affiliation: Food and Drug Administration, Ministry of Health and Welfare, No. 161-2, Kunyang Street, Nangang District, Taipei 115, Taiwan.
authors.forename: Pu-Hua
authors.initials: PH
authors.lastname: Lin
authors.affiliation: Department of Healthcare Management, Yuanpei University, No. 306, Yuanpei Street, Hsinchu 300, Taiwan.
authors.forename: Wei-Pin
authors.initials: WP
authors.lastname: Chang
authors.affiliation: Department of Early Childhood Care and Education, Kang-Ning Junior College of Medical Care and Management, No. 137, Lane 75, Section 3, Kangning Road, Neihu District, Taipei 114, Taiwan.
authors.forename: Shih-Chung
authors.identifier: 0000-0002-8830-5305
authors.initials: SC
authors.lastname: Hsu
authors.affiliation: Department of Nursing, School of Medicine, National Taiwan University, No. 1, Section 1, Jen Ai Road, Zhongzheng District, Taipei 100, Taiwan.
authors.forename: Jung-Chen
authors.initials: JC
authors.lastname: Chang
authors.affiliation: Department of Nursing, Ching-Kuo Institute of Management and Health, No. 336, Fu-Hsing Road, Zhongshan District, Keelung 203, Taiwan.
authors.forename: Ya-Chieh
authors.identifier: 0000-0002-8565-0816
authors.initials: YC
authors.lastname: Wu
authors.affiliation: Department of Health Industry Management, School of Health Care Management, Kainan University, No. 1, Kainan Road, Luzhu Shiang, Taoyuan 338, Taiwan.
authors.forename: Jin-Kuo
authors.initials: JK
authors.lastname: Pei
authors.affiliation: Department of Health Industry Management, School of Health Care Management, Kainan University, No. 1, Kainan Road, Luzhu Shiang, Taoyuan 338, Taiwan.
authors.forename: Chia-Hsien
authors.initials: CH
authors.lastname: Lin
mesh_terms: D000818:Animals; D004128:Dimethylnitrosamine / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D008103:Liver Cirrhosis / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004365:Drugs, Chinese Herbal; C103354:kamisyoyo san; D004128:Dimethylnitrosamine