title: Resistance training after myocardial infarction in rats: its role on cardiac and autonomic function.
abstract: BACKGROUND
  Although resistance exercise training is part of cardiovascular rehabilitation programs, little is known about its role on the cardiac and autonomic function after myocardial infarction.
  
  
  OBJECTIVE
  To evaluate the effects of resistance exercise training, started early after myocardial infarction, on cardiac function, hemodynamic profile, and autonomic modulation in rats.
  
  
  METHODS
  Male Wistar rats were divided into four groups: sedentary control, trained control, sedentary infarcted and trained infarcted rats. Each group with n = 9 rats. The animals underwent maximum load test and echocardiography at the beginning and at the end of the resistance exercise training (in an adapted ladder, 40% to 60% of the maximum load test, 3 months, 5 days/week). At the end, hemodynamic, baroreflex sensitivity and autonomic modulation assessments were made.
  
  
  RESULTS
  The maximum load test increased in groups trained control (+32%) and trained infarcted (+46%) in relation to groups sedentary control and sedentary infarcted. Although no change occurred regarding the myocardial infarction size and systolic function, the E/A ratio (-23%), myocardial performance index (-39%) and systolic blood pressure (+6%) improved with resistance exercise training in group trained infarcted. Concomitantly, the training provided additional benefits in the high frequency bands of the pulse interval (+45%), as well as in the low frequency band of systolic blood pressure (-46%) in rats from group trained infarcted in relation to group sedentary infarcted.
  
  
  CONCLUSIONS
  Resistance exercise training alone may be an important and safe tool in the management of patients after myocardial infarction, considering that it does not lead to significant changes in the ventricular function, reduces the global cardiac stress, and significantly improves the vascular and cardiac autonomic modulation in infarcted rats.
authors.affiliation: Laboratório do Movimento Humano, Universidade São Judas Tadeu, São Paulo, SP, Brazil.
authors.forename: Camilla Figueiredo
authors.initials: CF
authors.lastname: Grans
authors.affiliation: Laboratório do Movimento Humano, Universidade São Judas Tadeu, São Paulo, SP, Brazil.
authors.forename: Daniele Jardim
authors.initials: DJ
authors.lastname: Feriani
authors.affiliation: Laboratório do Movimento Humano, Universidade São Judas Tadeu, São Paulo, SP, Brazil.
authors.forename: Marcos Elias Vergilino
authors.initials: ME
authors.lastname: Abssamra
authors.affiliation: Laboratório do Movimento Humano, Universidade São Judas Tadeu, São Paulo, SP, Brazil.
authors.forename: Leandro Yanase
authors.initials: LY
authors.lastname: Rocha
authors.affiliation: Laboratório do Movimento Humano, Universidade São Judas Tadeu, São Paulo, SP, Brazil.
authors.forename: Nicolle Martins
authors.initials: NM
authors.lastname: Carrozzi
authors.affiliation: Departamento de Educação Física, Universidade Federal do Maranhão, São Luís, MA, Brazil.
authors.forename: Cristiano
authors.initials: C
authors.lastname: Mostarda
authors.affiliation: Laboratório de Hipertensão Experimental, Instituto do Coração, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Diego Mendrot
authors.initials: DM
authors.lastname: Figueroa
authors.affiliation: Laboratório de Fisiologia Translacional, Universidade Nove de Julho, São Paulo, SP, Brazil.
authors.forename: Kátia De
authors.initials: KD
authors.lastname: Angelis
authors.affiliation: Laboratório de Hipertensão Experimental, Instituto do Coração, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Maria Cláudia
authors.initials: MC
authors.lastname: Irigoyen
authors.affiliation: Laboratório do Movimento Humano, Universidade São Judas Tadeu, São Paulo, SP, Brazil.
authors.forename: Bruno
authors.initials: B
authors.lastname: Rodrigues
mesh_terms: D000818:Animals; D001341:Autonomic Nervous System / Q000503:physiopathology; D017704:Baroreflex / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D006339:Heart Rate; D006439:Hemodynamics / Q000502:physiology; D008297:Male; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000503:physiopathology*; D010805:Physical Conditioning, Animal / Q000502:physiology*; D011897:Random Allocation; D017208:Rats, Wistar; D055070:Resistance Training / Q000379:methods*; D014463:Ultrasonography; D016276:Ventricular Function / Q000502:physiology*; D020257:Ventricular Remodeling / Q000502:physiology*