title: Restricted nature of adult neural stem cells: re-evaluation of their potential for brain repair.
abstract: Neural stem cells (NSCs) in the walls of the lateral ventricles continue to produce new neurons and oligodendrocytes throughout life. The identification of NSCs, long-range neuronal migration, and the integration of new neurons into fully formed mature neural circuits-all in the juvenile or adult brain-has dramatically changed concepts in neurodevelopment and suggests new strategies for brain repair. Yet, the latter has to be seen in perspective: NSCs in the adult are heterogeneous and highly regionally specified; young neurons derived from these primary progenitors migrate and integrate in specific brain regions. Neurogenesis appears to have a function in brain plasticity rather than brain repair. If similar processes could be induced in regions of the brain that are normally not a target of new neurons, therapeutic neuronal replacement may one day reinstate neural circuit plasticity and possibly repair broken neural circuits.
authors.affiliation: Department of Neurological Surgery, The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco San Francisco, CA, USA.
authors.forename: Kirsten
authors.initials: K
authors.lastname: Obernier
authors.affiliation: Department of Neurological Surgery, The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco San Francisco, CA, USA.
authors.forename: Cheuk Ka
authors.initials: CK
authors.lastname: Tong
authors.affiliation: Department of Neurological Surgery, The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco San Francisco, CA, USA.
authors.forename: Arturo
authors.initials: A
authors.lastname: Alvarez-Buylla
keywords: V-SVZ; adult neural stem cells; brain repair; circuit plasticity; specification