title: Advance preferences regarding thrombolysis in patients at risk for stroke: a cross-sectional study.
abstract: BACKGROUND
  It is difficult to obtain informed consent for thrombolysis in stroke patients given the emergency setting, the need for a speedy decision and the effects of neurological deficits.
  
  
  OBJECTIVE
  To determine the advance preferences for thrombolysis of patients at risk for stroke following discussion of the potential risks and benefits.
  
  
  METHODS
  Cross-sectional survey.
  
  
  METHODS
  Data on benefits and risks of thrombolysis within 3 h and between 3 and 4.5 h after stroke were presented orally, in writing and pictorially to patients attending geriatric and stroke services in a teaching hospital with specified stroke risk factors and preferences for thrombolysis were recorded.
  
  
  RESULTS
  Of the 121 participants, 108 (89.3%; 95% confidence interval [CI] 82.4-93.7) would opt for thrombolysis within the 3-h period and 100 (82.6%; 95% CI 74.9-88.4) within the 3- to 4.5-h period after acute stroke (P = 0.04, McNemar's test for correlated proportions). Previous stroke or transient ischaemic attack was more common among those who agreed to thrombolysis (54.1% vs. 30.4%, P = 0.04) and those who opted for thrombolysis were significantly more likely to agree to have their preferences recorded and used in the event of a stroke than those who refused thrombolysis (88.8% vs. 30.4%, P = 0.002).
  
  
  CONCLUSIONS
  Advance discussion of the potential risks and benefits of thrombolysis in at-risk patients may improve decision making if thrombolysis is being considered and the patient can no longer make a decision.
authors.affiliation: From the Department of Medicine, National University of Ireland-Galway, Department of Geriatric Medicine, Galway University Hospitals and National University of Ireland, Galway, HRB Clinical Research Facility, Galway, Ireland.
authors.forename: T Ó
authors.initials: TÓ
authors.lastname: Flatharta
authors.affiliation: From the Department of Medicine, National University of Ireland-Galway, Department of Geriatric Medicine, Galway University Hospitals and National University of Ireland, Galway, HRB Clinical Research Facility, Galway, Ireland.
authors.forename: A
authors.initials: A
authors.lastname: Khan
authors.affiliation: From the Department of Medicine, National University of Ireland-Galway, Department of Geriatric Medicine, Galway University Hospitals and National University of Ireland, Galway, HRB Clinical Research Facility, Galway, Ireland.
authors.forename: T
authors.initials: T
authors.lastname: Walsh
authors.affiliation: From the Department of Medicine, National University of Ireland-Galway, Department of Geriatric Medicine, Galway University Hospitals and National University of Ireland, Galway, HRB Clinical Research Facility, Galway, Ireland.
authors.forename: M
authors.initials: M
authors.lastname: O'Donnell
authors.affiliation: From the Department of Medicine, National University of Ireland-Galway, Department of Geriatric Medicine, Galway University Hospitals and National University of Ireland, Galway, HRB Clinical Research Facility, Galway, Ireland sokanc@iolfree.ie.
authors.forename: S T
authors.initials: ST
authors.lastname: O'Keefe
mesh_terms: D000328:Adult; D016223:Advance Directives; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D003657:Decision Making; D005260:Female; D006801:Humans; D007494:Ireland; D008297:Male; D008875:Middle Aged; D010342:Patient Acceptance of Health Care; D057240:Patient Preference; D018570:Risk Assessment; D020521:Stroke / Q000188:drug therapy* / Q000209:etiology; D015912:Thrombolytic Therapy / Q000009:adverse effects / Q000379:methods / Q000523:psychology*; D013997:Time Factors