title: Alternating current electrophoretic deposition of antibacterial bioactive glass-chitosan composite coatings.
abstract: Alternating current (AC) electrophoretic deposition (EPD) was used to produce multifunctional composite coatings combining bioactive glass (BG) particles and chitosan. BG particles of two different sizes were used, i.e., 2 μm and 20-80 nm in average diameter. The parameter optimization and characterization of the coatings was conducted by visual inspection and by adhesion strength tests. The optimized coatings were investigated in terms of their hydroxyapatite (HA) forming ability in simulated body fluid (SBF) for up to 21 days. Fourier transform infrared (FTIR) spectroscopy results showed the successful HA formation on the coatings after 21 days. The first investigations were conducted on planar stainless steel sheets. In addition, scaffolds made from a TiAl4V6 alloy were considered to show the feasibility of coating of three dimensional structures by EPD. Because both BG and chitosan are antibacterial materials, the antibacterial properties of the as-produced coatings were investigated using E. coli bacteria cells. It was shown that the BG particle size has a strong influence on the antibacterial properties of the coatings.
authors.affiliation: Institute of Biomaterials, University of Erlangen-Nuremberg, Cauerstrasse 6, Erlangen 91058, Germany. sigrid.seuss@fau.de.
authors.forename: Sigrid
authors.initials: S
authors.lastname: Seuss
authors.affiliation: Institute of Biomaterials, University of Erlangen-Nuremberg, Cauerstrasse 6, Erlangen 91058, Germany. maja.lehmann@kabelmail.de.
authors.forename: Maja
authors.initials: M
authors.lastname: Lehmann
authors.affiliation: Institute of Biomaterials, University of Erlangen-Nuremberg, Cauerstrasse 6, Erlangen 91058, Germany. aldo.boccaccini@ww.uni-erlangen.de.
authors.forename: Aldo R
authors.initials: AR
authors.lastname: Boccaccini
mesh_terms: D000497:Alloys / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D048271:Chitosan / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000494:pharmacology; D017886:Durapatite / Q000737:chemistry; D004553:Electric Conductivity; D004586:Electrophoresis; D004926:Escherichia coli / Q000187:drug effects; D005898:Glass / Q000737:chemistry*; D013232:Steel / Q000737:chemistry
chemical_list: D000497:Alloys; D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; C528635:titanium aluminum alloy; D013232:Steel; D048271:Chitosan; D017886:Durapatite