title: Clinical and radiographic evaluation of the efficacy of platelet-rich plasma combined with hydroxyapatite bone graft substitutes in the treatment of intra-bony defects in maxillofacial region.
abstract: OBJECTIVE
  The aim of this study is to evaluate the efficacy of platelet-rich plasma (PRP) clinically and radiographically when combined with bovine derived hydroxyapatite (HA) bone grafting materials and resorbable collagen membranes for the treatment of intra-bony defects frequently seen at the distal aspect of mandibular second molars following the surgical extraction of fully impacted mandibular wisdom teeth.
  
  
  METHODS
  Eighteen patients were scheduled for post-operative visits at 1, 3 and 6 months post-operatively, probing depths were measured and digital panoramic radiographs were taken.
  
  
  RESULTS
  There were no significant differences on probing depths among two groups. Radiographic assessment also showed no significant difference among groups at 1st and 6th month intervals, while 3 months post-operatively the amount of radiographic density at the PRP side was significantly higher.
  
  
  CONCLUSIONS
  Combined use of PRP and bovine-derived HA graft materials for the treatment of intra-bony defects might be an appropriate approach when the main goal is providing earlier bone regeneration.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Bülent Ecevit University , Zonguldak , Turkey.
authors.forename: Mustafa Cenk
authors.initials: MC
authors.lastname: DurmuŞlar
authors.forename: Cansu
authors.initials: C
authors.lastname: Alpaslan
authors.forename: Gökhan
authors.initials: G
authors.lastname: Alpaslan
authors.forename: Melih
authors.initials: M
authors.lastname: Çakır
mesh_terms: D020341:Absorbable Implants; D000293:Adolescent; D000328:Adult; D016301:Alveolar Bone Loss / Q000601:surgery*; D000818:Animals; D015519:Bone Density / Q000502:physiology; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000627:therapeutic use*; D002417:Cattle; D003094:Collagen; D017886:Durapatite / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008964:Molar, Third / Q000601:surgery; D010514:Periodontal Pocket / Q000145:classification; D053657:Platelet-Rich Plasma / Q000502:physiology*; D019252:Radiography, Dental, Digital; D011862:Radiography, Panoramic; D014081:Tooth Extraction / Q000379:methods; D020390:Tooth Socket / Q000601:surgery; D014095:Tooth, Impacted / Q000601:surgery; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D018786:Bone Substitutes; D008567:Membranes, Artificial; D003094:Collagen; D017886:Durapatite
keywords: bone healing; hydroxyapatite; platelet rich plasma