title: The clinical outcomes of antimicrobial therapy in pediatric patients with nontyphoid salmonellosis with different levels of severity.
abstract: BACKGROUND
  To evaluate if a severity score could differentiate the severity of children with nontyphoid salmonellosis; clinical outcomes of antimicrobial therapy in nontyphoid salmonellosis children with different severities.
  
  
  METHODS
  Admitted children with nontyphoid salmonellosis from 1996 to 2009 were monitored. Enrolled patients were divided into no antibiotics, concordant, and discordant therapies. Besides, the patients were classified into mild, moderate, and severe group according to the severity score. Clinical outcomes were compared among them.
  
  
  RESULTS
  A total of 558 patients were enrolled. In no therapy subset, compared with mild group, patients had worse clinical outcomes and more complications in severe group. Patients receiving no therapy had better clinical outcomes in mild group. However, patients receiving concordant therapy (ceftriaxone) had better clinical outcomes in severe group.
  
  
  CONCLUSIONS
  The severity score and local antibiotic susceptibility could serve as guides for antibiotic prescription for severe nontyphoid salmonellosis in children. Inappropriate antibiotic use would worsen clinical outcomes in children with mild nontyphoid salmonellosis.
authors.affiliation: Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
authors.forename: Hong-Hsiang
authors.initials: HH
authors.lastname: Hu
authors.affiliation: Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan National Yang-Ming University, Taipei, Taiwan.
authors.forename: Christine C
authors.initials: CC
authors.lastname: Chiou
authors.affiliation: Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan National Yang-Ming University, Taipei, Taiwan.
authors.forename: Ming-Fang
authors.initials: MF
authors.lastname: Cheng
authors.affiliation: Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan National Yang-Ming University, Taipei, Taiwan.
authors.forename: Yao-Shen
authors.initials: YS
authors.lastname: Chen
authors.affiliation: Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
authors.forename: Sheng-Kai
authors.initials: SK
authors.lastname: Sheu
authors.affiliation: National Yang-Ming University, Taipei, Taiwan Taipei Veterans General Hospital, Taipei, Taiwan.
authors.forename: Tzee-Chung
authors.initials: TC
authors.lastname: Wu
authors.affiliation: Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan National Yang-Ming University, Taipei, Taiwan Chung Hwa University of Medical Technology, Tainan, Taiwan huang.ifei@yahoo.com.
authors.forename: I-Fei
authors.initials: IF
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D000465:Algorithms; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D007223:Infant; D007902:Length of Stay; D008297:Male; D017410:Practice Guidelines as Topic; D011446:Prospective Studies; D012307:Risk Factors; D012475:Salmonella / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D012480:Salmonella Infections / Q000175:diagnosis* / Q000188:drug therapy* / Q000382:microbiology; D012720:Severity of Illness Index; D013624:Taiwan; D062606:Tertiary Care Centers; D017211:Treatment Failure; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents
keywords: antibiotics; children; different severity; nontyphoid salmonellosis