title: Value of narrow band imaging in the early diagnosis of laryngeal cancer.
abstract: BACKGROUND
  Narrow band imaging (NBI) is a new imaging technique for the depiction of tumor-specific neoangiogenesis. The purpose of the present study was to assess the value of NBI in the early diagnosis of laryngeal cancer.
  
  
  METHODS
  This prospective study includes 205 consecutive patients with a laryngeal lesion scheduled for microlaryngoscopy. NBI was immediately performed after white light endoscopy (WLE), whereas excisional biopsy was carried out for histologic verification of diagnosis.
  
  
  RESULTS
  In identifying laryngeal cancer and its precursor lesions, NBI with WLE showed a significantly higher sensitivity (97% vs 79%) and accuracy (97% vs 90%) than WLE alone, but the specificity (96% vs 95%) was essentially equal in both methods.
  
  
  CONCLUSIONS
  NBI qualifies for rapid detection and delineation of suspicious lesions. Additionally, this noninvasive method is also beneficial in a variety of benign lesions.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Kantonsspital Baselland, Liestal, Switzerland.
authors.forename: Marcel
authors.initials: M
authors.lastname: Kraft
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Kantonsspital Baselland, Liestal, Switzerland.
authors.forename: Karolos
authors.initials: K
authors.lastname: Fostiropoulos
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Basel, Basel, Switzerland.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Gürtler
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Kantonsspital AG, Aarau, Switzerland.
authors.forename: André
authors.initials: A
authors.lastname: Arnoux
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Magdeburg, Magdeburg, Germany.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Davaris
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Magdeburg, Magdeburg, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Arens
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology*; D007828:Laryngoscopy / Q000379:methods; D008297:Male; D008875:Middle Aged; D062048:Narrow Band Imaging / Q000379:methods; D011230:Precancerous Conditions / Q000473:pathology; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity
keywords: cancer; diagnostic imaging; dysplasia; endoscopy; indirect laryngoscopy; laryngology; larynx; narrow band imaging; vocal fold