title: One-step shell polymerization of inorganic nanoparticles and their applications in SERS/nonlinear optical imaging, drug delivery, and catalysis.
abstract: Surface functionalized nanoparticles have found their applications in several fields including biophotonics, nanobiomedicine, biosensing, drug delivery, and catalysis. Quite often, the nanoparticle surfaces must be post-coated with organic or inorganic layers during the synthesis before use. This work reports a generally one-pot synthesis method for the preparation of various inorganic-organic core-shell nanostructures (Au@polymer, Ag@polymer, Cu@polymer, Fe3O4@polymer, and TiO2@polymer), which led to new optical, magnetic, and catalytic applications. This green synthesis involved reacting inorganic precursors and poly(styrene-alt-maleic acid). The polystyrene blocks separated from the external aqueous environment acting as a hydrophobic depot for aromatic drugs and thus illustrated the integration of functional nanoobjects for drug delivery. Among these nanocomposites, the Au@polymer nanoparticles with good biocompatibility exhibited shell-dependent signal enhancement in the surface plasmon resonance shift, nonlinear fluorescence, and surface-enhanced Raman scattering properties. These unique optical properties were used for dual-modality imaging on the delivery of the aromatic photosensitizer for photodynamic therapy to HeLa cells.
authors.affiliation: 1] Institute of Biomedical Engineering and Molecular Imaging Center, National Taiwan University, Taipei, 106, Taiwan [2].
authors.forename: Tzu-Ming
authors.initials: TM
authors.lastname: Liu
authors.affiliation: 1] Department of Chemical Engineering, National Taiwan University, Taipei, 106, Taiwan [2].
authors.forename: Jiashing
authors.initials: J
authors.lastname: Yu
authors.affiliation: 1] Department of Biomedical Imaging and Radiological Sciences National Yang-Ming University, Taipei, 112, Taiwan [2] Institute of Biophotonics, National Yang-Ming University, Taipei, 112, Taiwan [3] Biophotonics and Molecular Imaging Research Center (BMIRC), National Yang-Ming University, Taipei, 112, Taiwan.
authors.forename: C Allen
authors.initials: CA
authors.lastname: Chang
authors.affiliation: 1] Institute of Biophotonics, National Yang-Ming University, Taipei, 112, Taiwan [2] Biophotonics and Molecular Imaging Research Center (BMIRC), National Yang-Ming University, Taipei, 112, Taiwan.
authors.forename: Arthur
authors.initials: A
authors.lastname: Chiou
authors.affiliation: 1] Institute of Biophotonics, National Yang-Ming University, Taipei, 112, Taiwan [2] Biophotonics and Molecular Imaging Research Center (BMIRC), National Yang-Ming University, Taipei, 112, Taiwan [3] Institute of Biomedical Engineering, National Yang-Ming University, Taipei, 112, Taiwan.
authors.forename: Huihua Kenny
authors.initials: HK
authors.lastname: Chiang
authors.affiliation: National Synchrotron Radiation Research Center, Hsinchu, 300, Taiwan.
authors.forename: Yu-Chun
authors.initials: YC
authors.lastname: Chuang
authors.affiliation: Institute of Biomedical Engineering and Molecular Imaging Center, National Taiwan University, Taipei, 106, Taiwan.
authors.forename: Cheng-Han
authors.initials: CH
authors.lastname: Wu
authors.affiliation: Department of Chemical Engineering, National Taiwan University, Taipei, 106, Taiwan.
authors.forename: Che-Hao
authors.initials: CH
authors.lastname: Hsu
authors.affiliation: Institute of Biophotonics, National Yang-Ming University, Taipei, 112, Taiwan.
authors.forename: Po-An
authors.initials: PA
authors.lastname: Chen
authors.affiliation: 1] Institute of Biophotonics, National Yang-Ming University, Taipei, 112, Taiwan [2] Biophotonics and Molecular Imaging Research Center (BMIRC), National Yang-Ming University, Taipei, 112, Taiwan [3] Department of Applied Chemistry, National University of Kaohsiung, Kaohsiung, 811, Taiwan.
authors.forename: Chih-Chia
authors.initials: CC
authors.lastname: Huang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D002384:Catalysis; D004354:Drug Screening Assays, Antitumor; D006046:Gold / Q000737:chemistry; D055772:Green Chemistry Technology; D006367:HeLa Cells; D006801:Humans; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D061848:Optical Imaging; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology; D058105:Polymerization; D011137:Polystyrenes / Q000737:chemistry*; D012834:Silver / Q000737:chemistry; D014025:Titanium / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D058185:Magnetite Nanoparticles; D053769:Nanocapsules; D017319:Photosensitizing Agents; D011137:Polystyrenes; C009495:titanium dioxide; D012834:Silver; D006046:Gold; D014025:Titanium