title: Association between EHD3 gene and the cognitive function of patients with major depressive disorder.
abstract: OBJECTIVE
  To analyze the potential association between the EHD3 gene and the cognitive function of patients with major depressive disorder (MDD).
  
  
  METHODS
  A total of 47 MDD patients and 40 healthy controls were enrolled in this study. After their cognitive functions were analyzed, the scores of the MDD patients were used as the quantitative traits; by using the quantitative trait module in the UNPHASED software, we analyzed the potential association of the cognitive traits with the EHD3 gene.
  
  
  RESULTS
  The cognitive scores (WAIS-RC and WMS-R) of MDD patients were significantly lower than those of controls (P<0.05). The rs3769621 allele and genotype of EHD3 gene were significantly associated with the raw score and scaled score of WAIS-RC (Χ(2)=10.561, P=0.001; Χ(2)=7.922, P=0.019; Χ(2)=12.627, P=0.00038; Χ(2)=11.775, P=0.0027)and WMS-R (Χ(2)=8.762, P=0.003; Χ(2)=17.399, P=0.00016; Χ(2)=10.356, P=0.001; Χ(2)=14.958, P=0.00056). Such associations remained statistically significant after Bonferroni correction.
  
  
  CONCLUSIONS
  The EHD3 gene may be associated with the endophenotype of cognitive function in MDD patients.
authors.affiliation: National Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing 100005,China.
authors.forename: Le
authors.initials: L
authors.lastname: Wang
authors.affiliation: Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System of Ministry of Education, Tianjin Key Laboratory of Injuries,Variations,and Regeneration of the Nervous System, Department of Neuropathology,Tianjin Neurologic Institute,Tianjin Medical University General Hospital,Tianjin 300052,China.
authors.forename: Cui-juan
authors.initials: CJ
authors.lastname: Shi
authors.affiliation: National Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing 100005,China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D003071:Cognition; D003865:Major Depressive Disorder / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D055815:Young Adult
chemical_list: D002352:Carrier Proteins; C406447:EHD3 protein, human