title: Fabrication of hydrogel with cell adhesive micropatterns for mimicking the oriented tumor-associated extracellular matrix.
abstract: For mimicking the fibrous extracellular matrix (ECM), a facile method for patterning anticell adhesive substrate was novelly applied on agarose hydrogel. Without using masks or templates for etching, we applied the magnetic field-induced colloidal assembly of magnetic nanoparticles on the flat agarose hydrogel to form cell-adhesive micropatterns. Meanwhile, tuning the hydrogel substrate's modulus to fit real tissue was experimentally demonstrated. Magnetic nanobeads were also assembled on this hydrogel surface and formed more complete and regular patterns. The patterned hydrogel substrate could actually influence behaviors of different cancer cells, including adhesion, growth, and migration.
authors.affiliation: State Key Laboratory of Bioelectronics and Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering & Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University , Sipailou 2, Nanjing 210096, People's Republic of China.
authors.forename: Zhaobin
authors.initials: Z
authors.lastname: Guo
authors.forename: Ke
authors.initials: K
authors.lastname: Hu
authors.forename: Jianfei
authors.initials: J
authors.lastname: Sun
authors.forename: Tianzhu
authors.initials: T
authors.lastname: Zhang
authors.forename: Qiying
authors.initials: Q
authors.lastname: Zhang
authors.forename: Lina
authors.initials: L
authors.lastname: Song
authors.forename: Xizhi
authors.initials: X
authors.lastname: Zhang
authors.forename: Ning
authors.initials: N
authors.lastname: Gu
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry*; D002448:Cell Adhesion; D045744:Cell Line, Tumor; D005109:Extracellular Matrix / Q000737:chemistry*; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D020100:Hydrogels