title: 4-Halogeno-sydnones for fast strain promoted cycloaddition with bicyclo-[6.1.0]-nonyne.
abstract: New sydnone derivatives have been synthesized and screened for their capacity to undergo fast copper-free cycloaddition reaction with bicyclo-[6.1.0]-nonyne. The influences of substitution in positions N-3 and C-4 of sydnones have been particularly studied leading to the identification of highly reactive partners for bio-orthogonal ligation reactions.
authors.affiliation: CEA, iBiTecS, Service de Chimie Bioorganique et de Marquage, Gif sur Yvette, F-91191, France. frederic.taran@cea.fr.
authors.forename: Lucie
authors.initials: L
authors.lastname: Plougastel
authors.forename: Oleksandr
authors.initials: O
authors.lastname: Koniev
authors.forename: Simon
authors.initials: S
authors.lastname: Specklin
authors.forename: Elodie
authors.initials: E
authors.lastname: Decuypere
authors.forename: Christophe
authors.initials: C
authors.lastname: Créminon
authors.forename: David-Alexandre
authors.initials: DA
authors.lastname: Buisson
authors.forename: Alain
authors.initials: A
authors.lastname: Wagner
authors.forename: Sergii
authors.initials: S
authors.lastname: Kolodych
authors.forename: Frédéric
authors.initials: F
authors.lastname: Taran
mesh_terms: D001643:Bridged Bicyclo Compounds / Q000737:chemistry*; D061565:Cycloaddition Reaction; D006219:Halogens / Q000737:chemistry*; D066244:Proton Magnetic Resonance Spectroscopy
chemical_list: D001643:Bridged Bicyclo Compounds; D006219:Halogens; C556617:bicyclo(6.1.0)nonyne