title: Novel treatment strategies for brain tumors and metastases.
abstract: This review summarizes patent applications in the past 5 years for the management of brain tumors and metastases. Most of the recent patents discuss one of the following strategies: the development of new drug entities that specifically target the brain cells, the blood-brain barrier and the tumor cells, tailor-designing a novel carrier system that is able to perform multitasks and multifunction as a drug carrier, targeting vehicle and even as a diagnostic tool, direct conjugation of a US FDA approved drug with a targeting moiety, diagnostic moiety or PK modifying moiety, or the use of innovative nontraditional approaches such as genetic engineering, stem cells and vaccinations. Until now, there has been no optimal strategy to deliver therapeutic agents to the CNS for the treatment of brain tumors and metastases. Intensive research efforts are actively ongoing to take brain tumor targeting, and novel and targeted CNS delivery systems to potential clinical application.
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Egypt.
authors.forename: Salma E
authors.initials: SE
authors.lastname: El-Habashy
authors.forename: Alaa M
authors.initials: AM
authors.lastname: Nazief
authors.forename: Chris E
authors.initials: CE
authors.lastname: Adkins
authors.forename: Ming Ming
authors.initials: MM
authors.lastname: Wen
authors.forename: Amal H
authors.initials: AH
authors.lastname: El-Kamel
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Hamdan
authors.forename: Amira S
authors.initials: AS
authors.lastname: Hanafy
authors.forename: Tori O
authors.initials: TO
authors.lastname: Terrell
authors.forename: Afroz S
authors.initials: AS
authors.lastname: Mohammad
authors.forename: Paul R
authors.initials: PR
authors.lastname: Lockman
authors.forename: Mohamed Ismail
authors.initials: MI
authors.lastname: Nounou
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001921:Brain / Q000378:metabolism; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D009362:Neoplasm Metastasis / Q000188:drug therapy; D010330:Patents as Topic
chemical_list: D000970:Antineoplastic Agents