title: Podosomes in muscle cells and their role in the remodeling of neuromuscular postsynaptic machinery.
abstract: Podosomes are adhesive, matrix remodeling organelles that have been described in numerous cell types, including all three vertebrate muscle cell lineages. Podosomes have been intensively studied in smooth muscle cells, but they have also been described in cardiac myocytes and skeletal muscle cells where they are proposed to play a role in developmental remodeling of neuromuscular junction postsynaptic machinery. In this review, we summarize the current state of knowledge of podosomes in muscle cells, with a focus on their potential function at the maturing synapse.
authors.affiliation: Laboratory of Synaptogenesis, Cell Biology Department, Nencki Institute of Experimental Biology, Poland.
authors.forename: Krzysztof M
authors.initials: KM
authors.lastname: Bernadzki
authors.affiliation: Laboratory of Synaptogenesis, Cell Biology Department, Nencki Institute of Experimental Biology, Poland.
authors.forename: Katarzyna O
authors.initials: KO
authors.lastname: Rojek
authors.affiliation: Laboratory of Synaptogenesis, Cell Biology Department, Nencki Institute of Experimental Biology, Poland. Electronic address: t.proszynski@nencki.gov.pl.
authors.forename: Tomasz J
authors.initials: TJ
authors.lastname: Prószyński
mesh_terms: D000818:Animals; D002459:Cell Fusion; D022081:Cell Surface Extensions / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D018485:Muscle Fibers, Skeletal / Q000378:metabolism* / Q000648:ultrastructure; D032383:Myocytes, Cardiac / Q000378:metabolism / Q000648:ultrastructure; D032389:Myocytes, Smooth Muscle / Q000378:metabolism* / Q000648:ultrastructure; D009469:Neuromuscular Junction / Q000378:metabolism* / Q000648:ultrastructure
keywords: Acetylcholine; Amotl2; Invadopodia; Maturation; Myoblast; NMJ; Neuromuscular junction; Podosomes; Remodeling; Striated muscle