title: Legionella pneumophila type IV effectors hijack the transcription and translation machinery of the host cell.
abstract: Intracellular bacterial pathogens modulate the host response to persist and replicate inside a eukaryotic cell and cause disease. Legionella pneumophila, the causative agent of Legionnaires' disease, is present in freshwater environments and represents one of these pathogens. During coevolution with protozoan cells, L. pneumophila has acquired highly sophisticated and diverse strategies to hijack host cell processes. It secretes hundreds of effectors into the host cell, and these manipulate host signaling pathways and key cellular processes. Recently it has been shown that L. pneumophila is also able to alter the transcription and translation machinery of the host and to exploit epigenetic mechanisms in the cells it resides in to counteract host responses.
authors.affiliation: Institut Pasteur, Biologie des Bactéries Intracellulaires, Paris, France; Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 3525, Paris, France.
authors.forename: Monica
authors.initials: M
authors.lastname: Rolando
authors.affiliation: Institut Pasteur, Biologie des Bactéries Intracellulaires, Paris, France; Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 3525, Paris, France. Electronic address: cbuch@pasteur.fr.
authors.forename: Carmen
authors.initials: C
authors.lastname: Buchrieser
mesh_terms: D057890:Epigenomics; D054884:Host-Pathogen Interactions; D007113:Immunity, Innate / Q000235:genetics; D016952:Legionella pneumophila / Q000235:genetics* / Q000472:pathogenicity; D007877:Legionnaires' Disease / Q000235:genetics* / Q000382:microbiology; D014176:Protein Biosynthesis; D015398:Signal Transduction; D014158:Transcription, Genetic
keywords: Legionella pneumophila; epigenetics; intracellular pathogen; type IV effectors