title: Hepatosplenic T-cell lymphoma: a rare cause of hepatosplenomegaly.
abstract: We report a case of a man presenting with an unexplained fever, pancytopenia and hepatosplenomegaly without lymphadenopathy. Bone marrow flow cytometry strongly suggested hepatosplenic γδ T-cell lymphoma and infiltration of bone marrow samples by pathological T-lymphocytes confirmed the diagnosis. Despite chemotherapy the patient died 1 year after diagnosis. This is a rare disease that should be considered in the differential diagnosis of hepatosplenomegaly especially when it presents with B-symptoms and no lymph node enlargement. There is no standard therapy and the prognosis is poor.
authors.affiliation: Department of Internal Medicine, Hospital Santo António dos Capuchos, Lisbon, Portugal.
authors.forename: Ana Cristina
authors.initials: AC
authors.lastname: Lladó
authors.affiliation: Department of Hematology, Hospital Santo António dos Capuchos, Lisbon, Portugal.
authors.forename: Ana Luisa
authors.initials: AL
authors.lastname: Tomé
authors.affiliation: Department of Hematology, Hospital Santo António dos Capuchos, Lisbon, Portugal.
authors.forename: Maria
authors.initials: M
authors.lastname: Henrique
authors.affiliation: Department of Pathology, Hospital de São José, Lisbon, Portugal.
authors.forename: Pedro
authors.initials: P
authors.lastname: Farinha
mesh_terms: D001706:Biopsy; D001854:Bone Marrow Cells / Q000473:pathology*; D003937:Diagnosis, Differential; D005434:Flow Cytometry; D006529:Hepatomegaly / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D016399:Lymphoma, T-Cell / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D013160:Splenic Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D013163:Splenomegaly / Q000175:diagnosis / Q000209:etiology*; D014057:Tomography, X-Ray Computed