title: Preparation and characterization of spray-dried inhalable powders containing nanoaggregates for pulmonary delivery of anti-tubercular drugs.
abstract: This study aims to prepare spray-dried inhalable powders containing anti-tubercular drugs-loaded HPMC nanoaggregates for sustained delivery of drugs to the lung. Nanoaggregates were prepared by precipitation technique. Results showed that the powders obtained had excellent aerosolization property. High drug encapsulation efficiency was achieved in HPMC nano aggregates, ranging from 60% to 70%. A single pulmonary dose resulted in therapeutic drug concentrations 40% to 60% in the lungs and in other organs (< 5%) for 24 h. From this study, we can conclude that delivering drugs through pulmonary route is advantageous for local action in lungs.
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India.
authors.forename: Ranjot
authors.initials: R
authors.lastname: Kaur
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India.
authors.forename: Tarun
authors.initials: T
authors.lastname: Garg
authors.affiliation: b National Jalma Institute for Leprosy and other Mycobacterial Diseases , Agra , UP , India.
authors.forename: Umesh
authors.initials: U
authors.lastname: Das Gupta
authors.affiliation: b National Jalma Institute for Leprosy and other Mycobacterial Diseases , Agra , UP , India.
authors.forename: Pushpa
authors.initials: P
authors.lastname: Gupta
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India.
authors.forename: Goutam
authors.initials: G
authors.lastname: Rath
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India.
authors.forename: Amit Kumar
authors.initials: AK
authors.lastname: Goyal
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D000995:Antitubercular Agents / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology; D004339:Drug Compounding / Q000379:methods*; D016503:Drug Delivery Systems / Q000379:methods*; D065546:Drug Liberation; D005260:Female; D065347:Hypromellose Derivatives / Q000737:chemistry; D007538:Isoniazid / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008297:Male; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D059085:Nasal Sprays; D010316:Particle Size; D011208:Powders; D051381:Rats; D017208:Rats, Wistar; D012293:Rifampin / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology
chemical_list: D000995:Antitubercular Agents; D059085:Nasal Sprays; D011208:Powders; D065347:Hypromellose Derivatives; D007538:Isoniazid; D012293:Rifampin
keywords: HPMC polymer; nanoaggregates; pulmonary drug delivery; spray-dried powders