title: Protein-protein interactions and human cellular cofactors as new targets for HIV therapy.
abstract: Two novel approaches for the development of new drugs against AIDS are summarized each leading to the achievement of important discoveries in anti-HIV therapy. Despite the success of HAART in reducing mortality, resistant strains continue to emerge in the clinic, underscoring the importance of developing next-generation drugs. Protein-protein interactions and human cellular cofactors represent the new targets of tomorrow in HIV research. The most relevant results obtained in the last few years by the two new strategies are described herein.
authors.affiliation: Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via Aldo Moro 2, 53100 Siena, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Tintori
authors.affiliation: Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via Aldo Moro 2, 53100 Siena, Italy.
authors.forename: Annalaura
authors.initials: A
authors.lastname: Brai
authors.affiliation: Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via Aldo Moro 2, 53100 Siena, Italy; Dipartimento di Chimica e Tecnologie Farmaceutiche, Sapienza Università di Roma, Piazzale Aldo Moro 5, 00185 Roma, Italy.
authors.forename: Anna Lucia
authors.initials: AL
authors.lastname: Fallacara
authors.affiliation: Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via Aldo Moro 2, 53100 Siena, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Fazi
authors.affiliation: Dipartimento di Scienze Farmaceutiche, University of Genoa, Viale Benedetto XV 3, I-16132 Genova, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Schenone
authors.affiliation: Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via Aldo Moro 2, 53100 Siena, Italy; Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, BioLife Science Building, Suite 333, 1900 N 12th Street, Philadelphia, PA 19122, USA. Electronic address: botta.maurizio@gmail.com.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Botta
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D019380:Anti-HIV Agents / Q000494:pharmacology / Q000627:therapeutic use; D015704:CD4 Antigens / Q000378:metabolism; D053487:DEAD-box RNA Helicases / Q000378:metabolism; D015699:HIV Envelope Protein gp120 / Q000378:metabolism; D015658:HIV Infections / Q000188:drug therapy* / Q000378:metabolism; D019427:HIV Integrase; D006801:Humans; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D019713:Receptors, CCR5 / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D019380:Anti-HIV Agents; C584933:CCR5 protein, human; D015704:CD4 Antigens; D015699:HIV Envelope Protein gp120; C504649:PSIP1 protein, human; D019713:Receptors, CCR5; D014157:Transcription Factors; C514793:gp120 protein, Human immunodeficiency virus 1; D011505:Protein-Tyrosine Kinases; D019427:HIV Integrase; C119332:DDX3X protein, human; D053487:DEAD-box RNA Helicases; C514801:p31 integrase protein, Human immunodeficiency virus 1