title: The association of serotonin transporter gene polymorphism and geriatric depression: a meta-analysis.
abstract: Serotonin-transporter-linked promoter region (5-HTTLPR) polymorphism is the genetic variant coding for the serotonin transporter and may play an important role in the etiology of depression. However, genetic studies examining the relationship between 5-HTTLPR polymorphism and geriatric depression have produced inconsistent results. We conducted a meta-analysis to compare the frequency of 5-HTTLPR variants in geriatric depression cases and non-depressed controls in the elderly. A total of 5 studies involving 579 geriatric cases and 1372 non-depressed controls met the inclusion criteria. With strong statistical power, pooled odds ratios (ORs) and 95% confidence intervals (CIs) for genotypic analyses (S carrier versus L/L, S/S versus L/L) were provided. The results of our analysis indicate statistically significant association between S allele and the risk of geriatric depression (OR ScarriervsS/S=1.29, 95% CI 1.01-1.66; OR S/SvsL/L=1.68, 95% CI 1.20-2.35). Our findings suggest that 5-HTTLPR polymorphism is of importance in the development of geriatric depression.
authors.affiliation: School of Life Science, Shandong University, 27#, Shanda South Road, Jinan, Shandong, 250100, P.R. China.
authors.forename: Ze
authors.initials: Z
authors.lastname: Gao
authors.affiliation: School of Life Science, Shandong University, 27#, Shanda South Road, Jinan, Shandong, 250100, P.R. China.
authors.forename: Hanyu
authors.initials: H
authors.lastname: Yuan
authors.affiliation: School of Life Science, Shandong University, 27#, Shanda South Road, Jinan, Shandong, 250100, P.R. China.
authors.forename: Minghan
authors.initials: M
authors.lastname: Sun
authors.affiliation: Department of physiology, Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong, 250012, P.R. China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of medical psychology, Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong, 250012, P.R. China.
authors.forename: Yiqin
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of medical psychology, Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong, 250012, P.R. China. Electronic address: liudexiang@sdu.edu.cn.
authors.forename: Dexiang
authors.initials: D
authors.lastname: Liu
mesh_terms: D000368:Aged; D003863:Depression / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D015577:Geriatric Assessment; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D012307:Risk Factors; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins
keywords: Geriatric depression; Meta-analysis; S allele; Serotonin-transporter-linked promoter region; The elderly