title: Genetics of aging, progeria and lamin disorders.
abstract: Premature aging disorders, like Werner syndrome, Bloom's syndrome, and Hutchinson-Gilford Progeria Syndrome (HGPS), have been the subjects of immense interest as they recapitulate many of the phenotypes observed in physiological aging. They, therefore, not only provide model systems to study normal aging processes but also give valuable insights into the intricate mechanisms underlying senescence. Recent works on HGPS have revealed alterations in a spectrum of cellular and molecular pathways involved in the maintenance of genomic integrity, thus suggesting a profound impact of the nuclear lamina in nuclear organization, chromatin dynamics, regulation of gene expression and epigenetics.
authors.affiliation: Shenzhen Institute of Research and Innovation, The University of Hong Kong, Shenzhen, China.
authors.forename: Shrestha
authors.initials: S
authors.lastname: Ghosh
authors.affiliation: Shenzhen Institute of Research and Innovation, The University of Hong Kong, Shenzhen, China; Department of Biochemistry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong. Electronic address: Zhongjun@hku.hk.
authors.forename: Zhongjun
authors.initials: Z
authors.lastname: Zhou
mesh_terms: D000375:Aging / Q000235:genetics*; D042002:Chromatin Assembly and Disassembly; D044127:Epigenesis, Genetic / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D034904:Lamin Type A / Q000235:genetics*; D008957:Models, Genetic; D009154:Mutation; D011371:Progeria / Q000235:genetics*; D016615:Telomere / Q000235:genetics
chemical_list: D034904:Lamin Type A