title: Factor XII: a drug target for safe interference with thrombosis and inflammation.
abstract: Data from experimental animal models revealed an essential role for factor XII (FXII) in thrombotic occlusive diseases. In contrast to other blood coagulation factors, deficiency in the protease is not associated with abnormal bleeding from injury sites (hemostasis) in patients or in animals. Cumulatively, these findings suggest that FXII could be targeted as a new method of anticoagulation that is devoid of bleeding risks. An FXIIa-neutralizing antibody, 3F7, has been developed that inhibited thrombosis in an extracorporeal membrane oxygenation (ECMO) system as efficiently as heparin. However, in sharp contrast to heparin, 3F7 treatment was not associated with an increase in therapy-associated hemorrhage. In this review, we summarize current knowledge of FXII physiology and pharmacology.
authors.affiliation: Department of Molecular Medicine and Surgery, Karolinska Institutet and University Hospital, SE-171 76 Stockholm, Sweden; Center of Molecular Medicine, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.
authors.forename: Ellinor
authors.initials: E
authors.lastname: Kenne
authors.affiliation: Department of Molecular Medicine and Surgery, Karolinska Institutet and University Hospital, SE-171 76 Stockholm, Sweden; Center of Molecular Medicine, Karolinska University Hospital, SE-171 76 Stockholm, Sweden; Institute of Clinical Chemistry and Laboratory Medicien, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, Germany. Electronic address: thomas@renne.net.
authors.forename: Thomas
authors.initials: T
authors.lastname: Renné
mesh_terms: D000818:Animals; D000906:Antibodies / Q000009:adverse effects / Q000494:pharmacology; D000925:Anticoagulants / Q000009:adverse effects / Q000494:pharmacology*; D004195:Disease Models, Animal; D015199:Extracorporeal Membrane Oxygenation / Q000379:methods; D005174:Factor XII / Q000037:antagonists & inhibitors*; D015956:Factor XIIa / Q000037:antagonists & inhibitors; D006470:Hemorrhage / Q000139:chemically induced; D006493:Heparin / Q000009:adverse effects / Q000494:pharmacology; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000503:physiopathology; D013927:Thrombosis / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D000906:Antibodies; D000925:Anticoagulants; D005174:Factor XII; D006493:Heparin; D015956:Factor XIIa