title: Protective effect of quercetin against in vitro erythrocyte rheology alterations produced by arsenic.
abstract: Humans are exposed to heavy metals such as arsenic (As), through contaminated food and drinking water. The effect of As on RBC membrane is one of the most important biological effects. In a previous work, we have studied the AsVin vitro effect on erythrocytes biophysical properties discovering alterations regarding aggregability deformability, cell morphology, membrane fluidity and osmotic response. We have also observed that the presence of the metal produces an oxidative stress in RBCs that might be the origin of rheological impairment. In the present work we analyzed RBCs rheological properties associated with membrane fluidity and lipid peroxidation in presence of As and quercetin (Qc). From our results we can conclude that RBCs treatment with Qc is efficient to prevent the impairment of the mechanical properties of the cell membrane produced by the As, through oxygen reactive agents in the membrane structure, mainly on the lipids. This protective effect is observed in the preservation of the erythrocytes rheological properties and consequently in the maintenance of an appropriate blood flow, specially in the small vessels in the peripheral circulation.
authors.affiliation: Cátedra de Física Biológica, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Rosario, Santa Fe, Argentina.
authors.forename: G
authors.initials: G
authors.lastname: Hernández
authors.affiliation: Cátedra de Física Biológica, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Rosario, Santa Fe, Argentina.
authors.forename: A
authors.initials: A
authors.lastname: Bollini
authors.affiliation: Cátedra de Física Biológica, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Rosario, Santa Fe, Argentina.
authors.forename: G
authors.initials: G
authors.lastname: Mengarelli
authors.affiliation: Cátedra de Física Biológica, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Rosario, Santa Fe, Argentina.
authors.forename: M
authors.initials: M
authors.lastname: Rasia
authors.affiliation: Cátedra de Física Biológica, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Rosario, Santa Fe, Argentina.
authors.forename: C
authors.initials: C
authors.lastname: Casco
authors.affiliation: Cátedra de Física Biológica, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Rosario, Santa Fe, Argentina.
authors.forename: Ma F
authors.initials: MF
authors.lastname: Ruiz
authors.affiliation: Cátedra de Física Biológica, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Rosario, Santa Fe, Argentina.
authors.forename: M
authors.initials: M
authors.lastname: Visconti
authors.affiliation: Cátedra de Física, Facultad de Farmacia y Bioquímica, Universidad Nacional de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina.
authors.forename: M
authors.initials: M
authors.lastname: Huarte
authors.affiliation: Cátedra de Física, Facultad de Farmacia y Bioquímica, Universidad Nacional de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina.
authors.forename: E
authors.initials: E
authors.lastname: Rubin de Cellis
authors.affiliation: Cátedra de Física Biológica, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Rosario, Santa Fe, Argentina.
authors.forename: G
authors.initials: G
authors.lastname: Bazzoni
mesh_terms: D001151:Arsenic / Q000633:toxicity*; D004903:Erythrocyte Aggregation / Q000187:drug effects; D004907:Erythrocyte Deformability / Q000528:radiation effects; D004910:Erythrocyte Membrane / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects*; D018056:Hemorheology / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D011042:Poisons / Q000633:toxicity*; D020011:Protective Agents / Q000494:pharmacology*; D011794:Quercetin / Q000494:pharmacology*
chemical_list: D011042:Poisons; D020011:Protective Agents; D011794:Quercetin; D001151:Arsenic
keywords: Erythrocytes membrane properties; antioxidant; arsenic; protective effect; quercetin