title: The progression of posterior cortical atrophy to corticobasal syndrome: lumping or splitting neurodegenerative diseases?
abstract: BACKGROUND
  Posterior cortical atrophy is a clinical syndrome that is characterized by the progressive loss of visuospatial integration and is associated with neurodegenerative conditions.
  
  
  METHODS
  We describe a 60-year-old female with simultanagnosia, oculomotor apraxia, and optic ataxia for which she received an initial clinical diagnosis of posterior cortical atrophy. Three years later, she developed Balint's syndrome, Gerstmann's syndrome, left alien hand syndrome, smooth asymmetric (left) rigidity, cortical sensory loss, and spontaneous myoclonic jerks of the left arm, which suggested a final diagnosis of corticobasal syndrome.
  
  
  CONCLUSIONS
  This case report indicates that corticobasal syndrome may present with visuospatial deficits.
authors.affiliation: Operative Unit of Neurology, "Dimiccoli" General Hospital, Barletta, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Giorelli
authors.affiliation: Operative Unit of Neurology, "Dimiccoli" General Hospital, Barletta, Italy.
authors.forename: Nunzia Alessandra
authors.initials: NA
authors.lastname: Losignore
authors.affiliation: Operative Unit of Nuclear Medicine, "Dimiccoli" General Hospital, Barletta, Italy.
authors.forename: Junia
authors.initials: J
authors.lastname: Bagnoli
authors.affiliation: Operative Unit of Nuclear Medicine, "Dimiccoli" General Hospital, Barletta, Italy.
authors.forename: Pasquale
authors.initials: P
authors.lastname: Difazio
authors.affiliation: Operative Unit of Neurology, "Dimiccoli" General Hospital, Barletta, Italy.
authors.forename: Giovanni Bosco
authors.initials: GB
authors.lastname: Zimatore
keywords: Alzheimer's disease; Posterior cortical atrophy; SPECT (Single Photon Emission Computed Tomography); corticobasal syndrome; magnetic resonance imaging