title: Nanoscale methods for single-molecule electrochemistry.
abstract: The development of experiments capable of probing individual molecules has led to major breakthroughs in fields ranging from molecular electronics to biophysics, allowing direct tests of knowledge derived from macroscopic measurements and enabling new assays that probe population heterogeneities and internal molecular dynamics. Although still somewhat in their infancy, such methods are also being developed for probing molecular systems in solution using electrochemical transduction mechanisms. Here we outline the present status of this emerging field, concentrating in particular on optical methods, metal-molecule-metal junctions, and electrochemical nanofluidic devices.
authors.affiliation: MESA+ Institute for Nanotechnology, University of Twente, 7500 AE Enschede, the Netherlands; email: k.h.mathwig@utwente.nl , s.g.lemay@utwente.nl.
authors.forename: Klaus
authors.initials: K
authors.lastname: Mathwig
authors.forename: Thijs J
authors.initials: TJ
authors.lastname: Aartsma
authors.forename: Gerard W
authors.initials: GW
authors.lastname: Canters
authors.forename: Serge G
authors.initials: SG
authors.lastname: Lemay
mesh_terms: D000818:Animals; D004563:Electrochemistry / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D036103:Nanotechnology / Q000379:methods*; D011506:Proteins / Q000737:chemistry*
chemical_list: D011506:Proteins
keywords: electrochemical nanofluidics; electron transfer; fluorescence detection; metal-molecule-metal junctions