title: IL-10 and lymphotoxin-α expression profiles within marginal zone-like B-cell populations are associated with control of HIV-1 disease progression.
abstract: Understanding how the immune system facilitates or controls HIV-1 disease progression has important implications for the design of effective interventions. We report that although B-cell dysregulations associated with HIV-1 disease progression are accompanied by an overall decrease in the percentage of total blood B-cells, we observe an increase in relative frequencies of cells presenting characteristics of both transitional immature and first-line marginal zone (MZ) B-cell populations, we designated as precursor MZ-like B-cells. B-cells with similar attributes have been associated with IL-10 expression and "regulatory" potential. As such, the relative frequencies of precursor MZ-like B-cells expressing IL-10 are increased in the blood of viremic HIV-1-infected individuals when compared to HIV-negative subjects. Importantly, in aviremic HIV-1 Elite-Controllers (EC), we found unaltered relative percentages of precursor MZ-like B-cells which presented normal IL-10 expression patterns. Furthermore, EC had increased relative frequencies of blood MZ-like B-cells expressing LT-α. Thus in contrast to viremic HIV-1-infected individuals, EC present MZ-like B-cell populations which IL-10 and LT-α expression profiles may favour homeostasis of immune responses and lymphoid microenvironments.
authors.affiliation: Laboratoire d'Immunogénétique, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Quebec, Canada; Département de Microbiologie, Infectiologie et Immunologie de l'Université de Montréal, Montréal, Quebec, Canada.
authors.forename: Josiane
authors.initials: J
authors.lastname: Chagnon-Choquet
authors.affiliation: Laboratoire d'Immunogénétique, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Quebec, Canada; Département de Microbiologie, Infectiologie et Immunologie de l'Université de Montréal, Montréal, Quebec, Canada.
authors.forename: Julie
authors.initials: J
authors.lastname: Fontaine
authors.affiliation: Laboratoire d'Immunogénétique, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Quebec, Canada; Département de Microbiologie, Infectiologie et Immunologie de l'Université de Montréal, Montréal, Quebec, Canada.
authors.forename: Johanne
authors.initials: J
authors.lastname: Poudrier
authors.affiliation: Laboratoire d'Immunogénétique, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Quebec, Canada; Département de Microbiologie, Infectiologie et Immunologie de l'Université de Montréal, Montréal, Quebec, Canada.
authors.forename: Michel
authors.initials: M
authors.lastname: Roger
mesh_terms: D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D018450:Disease Progression; D015658:HIV Infections / Q000097:blood* / Q000473:pathology / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D008221:Lymphoid Tissue / Q000276:immunology / Q000473:pathology; D008233:Lymphotoxin-alpha / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: C508609:IL10 protein, human; D008233:Lymphotoxin-alpha; D016753:Interleukin-10