title: Characterization of a multi-element clinical HIFU system using acoustic holography and nonlinear modeling.
abstract: High-intensity focused ultrasound (HIFU) is a treatment modality that relies on the delivery of acoustic energy to remote tissue sites to induce thermal and/or mechanical tissue ablation. To ensure the safety and efficacy of this medical technology, standard approaches are needed for accurately characterizing the acoustic pressures generated by clinical ultrasound sources under operating conditions. Characterization of HIFU fields is complicated by nonlinear wave propagation and the complexity of phased-array transducers. Previous work has described aspects of an approach that combines measurements and modeling, and here we demonstrate this approach for a clinical phased-array transducer. First, low amplitude hydrophone measurements were performed in water over a scan plane between the array and the focus. Second, these measurements were used to holographically reconstruct the surface vibrations of the transducer and to set a boundary condition for a 3-D acoustic propagation model. Finally, nonlinear simulations of the acoustic field were carried out over a range of source power levels. Simulation results were compared with pressure waveforms measured directly by hydrophone at both low and high power levels, demonstrating that details of the acoustic field, including shock formation, are quantitatively predicted.
authors.forename: Wayne
authors.initials: W
authors.lastname: Kreider
authors.forename: Petr V
authors.initials: PV
authors.lastname: Yuldashev
authors.forename: Oleg A
authors.initials: OA
authors.lastname: Sapozhnikov
authors.forename: Navid
authors.initials: N
authors.lastname: Farr
authors.forename: Ari
authors.initials: A
authors.lastname: Partanen
authors.forename: Michael R
authors.initials: MR
authors.lastname: Bailey
authors.forename: Vera A
authors.initials: VA
authors.lastname: Khokhlova
mesh_terms: D000162:Acoustics; D003198:Computer Simulation; D054459:Elasticity Imaging Techniques / Q000379:methods*; D004867:Equipment Design; D019544:Equipment Failure Analysis / Q000379:methods; D057086:High-Intensity Focused Ultrasound Ablation / Q000295:instrumentation* / Q000379:methods*; D006696:Holography / Q000379:methods*; D008365:Manometry / Q000379:methods*; D017711:Nonlinear Dynamics; D011312:Pressure; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*; D012542:Scattering, Radiation