title: Type of tumour, gender and time since diagnosis affect differently health-related quality of life in adolescent survivors.
abstract: Research findings about health-related quality of life (HRQoL) of childhood cancer survivors are mixed and the features which could modulate these results have not been investigated rigorously. This research aims to improve the knowledge on these topics. Thus, HRQoL between central nervous system (CNST) and non-central nervous system (non-CNST) adolescent cancer survivors was compared. The influence of selected factors (gender and years since diagnosis) on HRQoL was also analysed. In a cross-sectional design, 78 survivors (12-20 years) who were ≥ 1 year free of oncological treatment answered the self-reported version of the KIDSCREEN-52. HRQoL mean scores of CNST survivors were lower in comparison with non-CNST in physical well-being and social support and peers dimensions. Furthermore, female gender was also related to lower HRQoL scores for both types of tumours in physical well-being and autonomy dimensions. Additionally, scores on psychological well-being, social support and peers, parent relations and home life and school environment dimensions decrease with length of time from diagnosis. Therefore, diagnosis of CNST and gender were related to lower HRQoL among survivors in some dimensions, whereas time from diagnosis was related to impaired HRQoL in other features. These results can help to design tailored interventions and psychosocial guidelines to follow-up survivors.
authors.affiliation: Department of Pediatric Oncology and Hematology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.|Department of Basic Psychology, Universitat Autònoma de Barcelona, Bellaterra, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Pérez-Campdepadrós
authors.affiliation: Department of Basic Psychology, Universitat Autònoma de Barcelona, Bellaterra, Spain.|Departament of Psychiatry, Hospital Universitari Vall d'Hebron-Fundació Institut de Recerca, Barcelona, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Castellano-Tejedor
authors.affiliation: Department of Pediatric Oncology and Hematology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Sábado-Álvarez
authors.affiliation: Department of Pediatric Oncology and Hematology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Gros-Subías
authors.affiliation: Department of Basic Psychology, Universitat Autònoma de Barcelona, Bellaterra, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Capdevila
authors.affiliation: Department of Basic Psychology, Universitat Autònoma de Barcelona, Bellaterra, Spain.
authors.forename: T
authors.initials: T
authors.lastname: Blasco-Blasco
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D016543:Central Nervous System Neoplasms / Q000523:psychology; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000523:psychology*; D011788:Quality of Life / Q000523:psychology; D012737:Sex Factors; D017741:Survivors / Q000523:psychology*; D013997:Time Factors; D055815:Young Adult
keywords: adolescents; brain tumours; cancer; leukaemia; quality of life; tumour