title: Intrinsic and task-evoked network architectures of the human brain.
abstract: Many functional network properties of the human brain have been identified during rest and task states, yet it remains unclear how the two relate. We identified a whole-brain network architecture present across dozens of task states that was highly similar to the resting-state network architecture. The most frequent functional connectivity strengths across tasks closely matched the strengths observed at rest, suggesting this is an "intrinsic," standard architecture of functional brain organization. Furthermore, a set of small but consistent changes common across tasks suggests the existence of a task-general network architecture distinguishing task states from rest. These results indicate the brain's functional network architecture during task performance is shaped primarily by an intrinsic network architecture that is also present during rest, and secondarily by evoked task-general and task-specific network changes. This establishes a strong relationship between resting-state functional connectivity and task-evoked functional connectivity-areas of neuroscientific inquiry typically considered separately.
authors.affiliation: Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA; Department of Psychology, Washington University, St. Louis, MO 63130, USA. Electronic address: michael.cole@rutgers.edu.
authors.forename: Michael W
authors.initials: MW
authors.lastname: Cole
authors.affiliation: Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Danielle S
authors.initials: DS
authors.lastname: Bassett
authors.affiliation: Department of Neurology, Washington University, St. Louis, MO 63110, USA.
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Power
authors.affiliation: Department of Psychology, Washington University, St. Louis, MO 63130, USA.
authors.forename: Todd S
authors.initials: TS
authors.lastname: Braver
authors.affiliation: Department of Psychology, Washington University, St. Louis, MO 63130, USA; Department of Neurology, Washington University, St. Louis, MO 63110, USA.
authors.forename: Steven E
authors.initials: SE
authors.lastname: Petersen
mesh_terms: D000328:Adult; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009415:Nerve Net / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology*; D012146:Rest / Q000502:physiology*; D055815:Young Adult