title: Low-level laser therapy ameliorates disease progression in a mouse model of Alzheimer's disease.
abstract: Low-level laser therapy (LLLT) has been used to treat inflammation, tissue healing, and repair processes. We recently reported that LLLT to the bone marrow (BM) led to proliferation of mesenchymal stem cells (MSCs) and their homing in the ischemic heart suggesting its role in regenerative medicine. The aim of the present study was to investigate the ability of LLLT to stimulate MSCs of autologous BM in order to affect neurological behavior and β-amyloid burden in progressive stages of Alzheimer's disease (AD) mouse model. MSCs from wild-type mice stimulated with LLLT showed to increase their ability to maturate towards a monocyte lineage and to increase phagocytosis activity towards soluble amyloid beta (Aβ). Furthermore, weekly LLLT to BM of AD mice for 2 months, starting at 4 months of age (progressive stage of AD), improved cognitive capacity and spatial learning, as compared to sham-treated AD mice. Histology revealed a significant reduction in Aβ brain burden. Our results suggest the use of LLLT as a therapeutic application in progressive stages of AD and imply its role in mediating MSC therapy in brain amyloidogenic diseases.
authors.affiliation: Department of Neurobiology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Dorit
authors.initials: D
authors.lastname: Farfara
authors.forename: Hana
authors.initials: H
authors.lastname: Tuby
authors.forename: Dorit
authors.initials: D
authors.lastname: Trudler
authors.forename: Ella
authors.initials: E
authors.lastname: Doron-Mandel
authors.forename: Lidya
authors.initials: L
authors.lastname: Maltz
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Vassar
authors.forename: Dan
authors.initials: D
authors.lastname: Frenkel
authors.forename: Uri
authors.initials: U
authors.lastname: Oron
mesh_terms: D000544:Alzheimer Disease / Q000628:therapy*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000818:Animals; D003071:Cognition; D028022:Low-Level Light Therapy; D008297:Male; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D009000:Monocytes / Q000166:cytology / Q000378:metabolism; D010587:Phagocytosis
chemical_list: D016229:Amyloid beta-Peptides