title: Genetics of juvenile idiopathic arthritis: new tools bring new approaches.
abstract: OBJECTIVE
  In juvenile idiopathic arthritis (JIA), there are now more than 25 regions represented by single nucleotide polymorphisms that show strong genetic associations. The causal variants and corresponding functions have not yet been defined for the majority of these regions. Here, we review current JIA association findings and the recent progress in the annotation of noncoding portion of the human genome as well as the new technologies necessary to apply this knowledge to JIA association findings.
  
  
  RESULTS
  An international collaboration was able to amass sufficient numbers of JIA and control samples to identify significantly robust genetic associations for JIA. The Encyclopedia of DNA Elements project and the National Institutes of Health (NIH) Roadmap Epigenetics Program have now annotated more than 80% of the noncoding genome, important in understanding the impact of risk loci, the majority of which fall outside of protein coding regions. Recent technological advances in high throughput sequencing, chromatin structure determination, transcription factor and enhancer binding site mapping and genome editing will likely provide a basis for understanding JIA genetic risk.
  
  
  CONCLUSIONS
  Understanding the role of genetic variation in the cause of JIA will provide insight for disease mechanism and may explain disease heterogeneity between JIA subtypes and between autoimmune diseases in general.
authors.affiliation: aDivision of Rheumatology and the Center for Autoimmune Disease Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio bDivision of Pediatric Rheumatology, Department of Pediatrics and Genetics,, Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: Halima
authors.initials: H
authors.lastname: Moncrieffe
authors.forename: Sampath
authors.initials: S
authors.lastname: Prahalad
authors.forename: Susan D
authors.initials: SD
authors.lastname: Thompson
mesh_terms: D001171:Arthritis, Juvenile / Q000235:genetics*; D064113:CRISPR-Cas Systems; D002648:Child; D015870:Gene Expression; D055106:Genome-Wide Association Study; D059811:HLA-DRB1 Chains / Q000235:genetics; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D017393:RNA Editing; D022661:RNA, Untranslated / Q000235:genetics; D012307:Risk Factors
chemical_list: D059811:HLA-DRB1 Chains; D022661:RNA, Untranslated