title: Distribution of EV71 receptors SCARB2 and PSGL-1 in human tissues.
abstract: The aim of this study was to investigate the distribution of Enterovirus 71 (EV71) receptors SCARB2 and PSGL-1 in human tissues. The samples were chosen from archived specimens, and the profiles of two receptors were detected in the gastrointestinal tract, lung, and brain in situ by immunohistochemistry. SCARB2 was detected in all the tissues studied, and strong staining was observed in the gastric fundus gland, mucosal and glandular epithelia of the intestine. Similar expression was found in bronchial epithelia and pneumocytes. In addition, SCARB2 was observed in the esophagus/gastric mucosal epithelia, neuron, glial cells, and blood vessels and the perivascular tissues of the brain. By comparison, PSGL-1 was expressed weakly in the mucosal and glandular epithelia of the small intestine and colon. PSGL-1 was expressed in a few bronchial epithelia, and weak staining was observed in the pneumocytes. However, PSGL-1 was found easily in the lamina propria of all the tissues studied, and strong staining of PSGL-1 was also observed in the neurons and glial cells. The distribution of the SCARB2 and PSGL-1 in human gastrointestinal tract, lung, and brain tissues correlated with the distribution of pathological changes seen in EV71 infection. The widespread prevalence of these receptors may help explain the multiple organ involvement in infection with EV71.
authors.affiliation: Department of Cell Biology and Genetics, Shantou University Medical College, 22 Xinling Road, Shantou 515041, China; Department of Pathology, The First Affiliated Hospital of Shantou University Medical College, Changpin Road, Shantou 515041, China. Electronic address: jiaoxiaoyang@yahoo.com.
authors.forename: Xiao-Yang
authors.initials: XY
authors.lastname: Jiao
authors.affiliation: Department of Cell Biology and Genetics, Shantou University Medical College, 22 Xinling Road, Shantou 515041, China.
authors.forename: Li
authors.initials: L
authors.lastname: Guo
authors.affiliation: Department of Cell Biology and Genetics, Shantou University Medical College, 22 Xinling Road, Shantou 515041, China.
authors.forename: Dong-Yang
authors.initials: DY
authors.lastname: Huang
authors.affiliation: Department of Cell Biology and Genetics, Shantou University Medical College, 22 Xinling Road, Shantou 515041, China.
authors.forename: Xiao-Lan
authors.initials: XL
authors.lastname: Chang
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Shantou University Medical College, Changpin Road, Shantou 515041, China. Electronic address: qqc888@21cn.com.
authors.forename: Qian-Cheng
authors.initials: QC
authors.lastname: Qiu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain / Q000378:metabolism / Q000473:pathology / Q000821:virology; D002460:Cell Line; D029821:Enterovirus A, Human / Q000235:genetics / Q000378:metabolism*; D004769:Enterovirus Infections / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D005260:Female; D041981:Gastrointestinal Tract / Q000378:metabolism / Q000473:pathology / Q000821:virology; D006801:Humans; D008168:Lung / Q000378:metabolism / Q000473:pathology / Q000821:virology; D051907:Lysosomal Membrane Proteins / Q000378:metabolism*; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008875:Middle Aged; D051116:Receptors, Scavenger / Q000378:metabolism*; D011991:Receptors, Virus / Q000378:metabolism*; D055815:Young Adult
chemical_list: D051907:Lysosomal Membrane Proteins; D008562:Membrane Glycoproteins; C084882:P-selectin ligand protein; D051116:Receptors, Scavenger; D011991:Receptors, Virus; C074299:SCARB2 protein, human
keywords: EV71 virus; HFMD; PSGL-1; SCARB2