title: Management of acute kidney injury with continuous venovenous haemodiafiltration in a cat.
abstract: Continuous renal replacement therapy is an emerging technique for the treatment of acute kidney injury (AKI). Data regarding its use in cats are limited. This report describes the use of a novel continuous renal replacement therapy (CRRT) system for the treatment of AKI in a cat. A 1.3-year-old cat developed uraemic signs following the administration of a non-steroidal anti-inflammatory agent for the treatment of a suspect traumatic episode. CRRT was provided with a Prismaflex Gambro machine used in continuous venovenous haemodiafiltration mode, with an AN-69 surface-treated membrane, synthetic colloid priming and heparin anticoagulation. Two treatment cycles were performed, totalling 51 h of CRRT. The treatment was effective in controlling uraemic signs, and no major complications were noted. Owing to financial constraints the owners declined further CRRT treatments, and on day 8 of hospitalisation, owing to the lack of significant clinical improvement, humane euthanasia was performed. The set-up detailed in this report provides a viable option for the initial treatment of cats with AKI.
authors.affiliation: Department of Veterinary Clinical Science and Services, The Royal Veterinary College, North Mymms, Hatfield, UK gstanzani@rvc.ac.uk.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Stanzani
authors.affiliation: Department of Veterinary Clinical Science and Services, The Royal Veterinary College, North Mymms, Hatfield, UK.
authors.forename: Rosanne E
authors.initials: RE
authors.lastname: Jepson
authors.affiliation: Department of Veterinary Clinical Science and Services, The Royal Veterinary College, North Mymms, Hatfield, UK.
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Chan
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced / Q000662:veterinary*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D002371:Cat Diseases / Q000209:etiology* / Q000628:therapy*; D002415:Cats; D005065:Euthanasia; D017583:Hemodiafiltration / Q000379:methods / Q000662:veterinary*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal