title: JG6, a novel marine-derived oligosaccharide, suppresses breast cancer metastasis via binding to cofilin.
abstract: Cofilin, an actin-binding protein which disassembles actin filaments, plays an important role in invasion and metastasis. Here, we discover that JG6, an oligomannurarate sulfate, binds to cofilin, suppresses the migration of human breast cancer cells and cancer metastasis in breast cancer xenograft model. Mechanistically, JG6 occupies actin-binding sites of cofilin, thereby disrupting cofilin modulated actin turnover. Our results highlight the significance of cofilin in cancer and suggest JG6, a cofilin inhibitor, to treat metastatic cancer.
authors.affiliation: Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P.R.China.
authors.forename: Xun
authors.initials: X
authors.lastname: Huang
authors.forename: Danni
authors.initials: D
authors.lastname: Sun
authors.forename: Qiuming
authors.initials: Q
authors.lastname: Pan
authors.forename: Weiwei
authors.initials: W
authors.lastname: Wen
authors.forename: Yi
authors.initials: Y
authors.lastname: Chen
authors.forename: Xianliang
authors.initials: X
authors.lastname: Xin
authors.forename: Min
authors.initials: M
authors.lastname: Huang
authors.affiliation: Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P.R.China.
authors.forename: Jian
authors.initials: J
authors.lastname: Ding
authors.affiliation: Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P.R.China.
authors.forename: Meiyu
authors.initials: M
authors.lastname: Geng
mesh_terms: D051339:Actin Depolymerizing Factors / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000199:Actins / Q000378:metabolism; D000818:Animals; D001665:Binding Sites; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D005260:Female; D006801:Humans; D061986:MCF-7 Cells; D051379:Mice; D008819:Mice, Nude; D009362:Neoplasm Metastasis; D009844:Oligosaccharides / Q000494:pharmacology*; D011485:Protein Binding; D023041:Xenograft Model Antitumor Assays
chemical_list: D051339:Actin Depolymerizing Factors; D000199:Actins; D009844:Oligosaccharides