title: The impact of Platelet Rich Plasma (PRP) in osseointegration of oral implants in dental panoramic radiography: texture based evaluation.
abstract: OBJECTIVE
  In this study the temporal texture differentiation associated with the bone formation properties, around loaded oral implants after Platelet Rich Plasma (PRP) employment, was investigated in Panoramic Radiographs.
  
  
  METHODS
  Thirty eligible patients are randomly assigned to two groups. The test group received PRP application around new implants, while in the control group no PRP treatment was made. The bone-to-implant contact region was analyzed in a clinical sample of 60 Digitized Panoramic Radiographs, 30 corresponding to immediate implant loading (Class-I) and 30 after an 8 month follow-up period (Class-II). This region was sampled by 1146 circular Regions-of-Interest (ROIs), resulting from a specifically designed segmentation scheme based on Markov-Random-Fields (MRF). From each ROI, 41 textural features were extracted, then reduced to a subset of 4 features due to redundancy and employed as input to Receiver-Operating-Characteristic (ROC) analysis, to assess the textural differentiation between two classes.
  
  
  RESULTS
  The selected subset, achieved Area-Under-Curve (AUC) values ranging from 0.77-0.81 in the PRP group, indicating the significant temporal textural differentiation has been made. In the control group, the AUC values ranged from 0.56-0.68 demonstrating lesser osseo integration activity.
  
  
  CONCLUSIONS
  This study provides evidences that PRP application may favor bone formation around loaded dental implants that could modify the dental treatment planning.
authors.affiliation: Department of Radiology, School of Medicine, University of Patras, Patras, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Georgakopoulos
authors.affiliation: Department of Medical Instrumentation Technology Technological Educational Institution of Athens, Egaleo, Athens, Greece.
authors.forename: Stavros
authors.initials: S
authors.lastname: Tsantis
authors.affiliation: University Alfonso X El Sabio, School of Dentistry, Madrid, Spain.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Georgakopoulos
authors.affiliation: Department of Medical Physics, School of Medicine, University of Patras, Patras, Greece.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Korfiatis
authors.affiliation: IRF in Microdentistry, Florence, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Fanti
authors.affiliation: IRF in Microdentistry, Florence, Italy.
authors.forename: Marialaura
authors.initials: M
authors.lastname: Martelli
authors.affiliation: Department of Medical Physics, School of Medicine, University of Patras, Patras, Greece.
authors.forename: Lena
authors.initials: L
authors.lastname: Costaridou
authors.affiliation: Department of Radiology, School of Medicine, University of Patras, Patras, Greece.
authors.forename: Theodoros
authors.initials: T
authors.lastname: Petsas
authors.affiliation: Department of Medical Physics, School of Medicine, University of Patras, Patras, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Panayiotakis
authors.affiliation: IRF in Microdentistry, Florence, Italy.
authors.forename: Francesco Saverio
authors.initials: FS
authors.lastname: Martelli
keywords: Markov Random Fields; Platelet Rich Plasma; dental implants; implant segmentation; medical image texture analysis; radiography