title: Effect of methylphenidate treatment on appetite and levels of leptin, ghrelin, adiponectin, and brain-derived neurotrophic factor in children and adolescents with attention deficit and hyperactivity disorder.
abstract: OBJECTIVE
  We aimed to explore whether the use of methylphenidate relates leptin, ghrelin, adiponectin, and brain-derived neurotrophic factor (BDNF). In addition, the relationship between methylphenidate-related weight loss in attention deficit hyperactivity disorder (ADHD) patients and these biomolecules were evaluated.
  
  
  METHODS
  Thirty ADHD patients receiving methylphenidate and 20 healthy controls were included. Leptin, ghrelin, adiponectin, and BDNF levels were measured at baseline and after two-month treatment in both groups.
  
  
  RESULTS
  At baseline, leptin, ghrelin, adiponectin, and BDNF levels were similar in the ADHD and control groups. The most common adverse events occurring in the ADHD group after a 2-month treatment period included loss of appetite (70%) and weight loss (66.7%). A significant difference was found in body weight, BMI, and CGI scores of the ADHD patients after the treatment. While post-treatment ghrelin and adiponectin levels were significantly higher in the ADHD group, BDNF level was significantly lower. Post-treatment decrease in leptin levels was not significant.
  
  
  CONCLUSIONS
  Leptin and BDNF were not associated with poor appetite and/or weight loss due to methylphenidate treatment. However, ghrelin and adiponectin might be biomolecules that play a role in underlying neurobiological mechanisms of methylphenidate-related appetite or weight loss.
authors.affiliation: Child and Adolescent Psychiatry Clinic, Balıkesir Atatürk State Hospital , Balikesir , Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Sahin
authors.forename: Murat
authors.initials: M
authors.lastname: Yuce
authors.forename: Hasan
authors.initials: H
authors.lastname: Alacam
authors.forename: Koray
authors.initials: K
authors.lastname: Karabekiroglu
authors.forename: Gokce Nur
authors.initials: GN
authors.lastname: Say
authors.forename: Osman
authors.initials: O
authors.lastname: Salıs
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D001066:Appetite / Q000187:drug effects*; D001289:Attention Deficit Disorder with Hyperactivity / Q000097:blood* / Q000188:drug therapy; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D002648:Child; D003692:Delayed-Action Preparations / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008774:Methylphenidate / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D052242:Adiponectin; D019208:Brain-Derived Neurotrophic Factor; D000697:Central Nervous System Stimulants; D003692:Delayed-Action Preparations; D054439:Ghrelin; D020738:Leptin; D008774:Methylphenidate
keywords: Attention deficit hyperactivity disorder; adiponectin; brain-derived neurotrophic factor; ghrelin; leptin; methylphenidate