title: MMP-14 overexpression correlates with poor prognosis in non-small cell lung cancer.
abstract: Matrix metalloproteinase-14 (MMP-14) has been demonstrated to play an important role in tumor progression. The aim of this study was to analyze the correlation between MMP-14 expression and clinicopathologic features and its prognostic significance in non-small cell lung cancer (NSCLC). Immunohistochemical staining for MMP-14 protein was performed in 104 patients with NSCLC. High levels of MMP-14 protein were positively correlated with the status of clinical stage (I-II vs. III-IV; P < 0.001), N classification (N0-N1 vs. N2-N3; P < 0.001), distant metastasis (no vs. yes; P = 0.014), and differentiated degree (high vs. low or undifferentiated; P = 0.001). The patients with higher MMP-14 expression of protein had shorter survival time than patients with low MMP-14 expression. Multivariate analysis indicated that the level of MMP-14 expression was an independent prognostic indicator (P < 0.001) for the survival of patients with NSCLC. In conclusion, MMP-14 is a potential unfavorable prognostic factor for patients with NSCLC.
authors.affiliation: Cancer Center, Affiliated Hospital of Guangdong Medical College, No. 57 People's Avenue South, Zhanjiang, 524002, Guangdong, People's Republic of China.
authors.forename: Yu-Zhou
authors.initials: YZ
authors.lastname: Wang
authors.forename: Kun-Peng
authors.initials: KP
authors.lastname: Wu
authors.forename: Ai-Bing
authors.initials: AB
authors.lastname: Wu
authors.forename: Zhi-Cheng
authors.initials: ZC
authors.lastname: Yang
authors.forename: Jin-Mei
authors.initials: JM
authors.lastname: Li
authors.forename: Yan-Li
authors.initials: YL
authors.lastname: Mo
authors.forename: Meng
authors.initials: M
authors.lastname: Xu
authors.forename: Bin
authors.initials: B
authors.lastname: Wu
authors.forename: Zhi-Xiong
authors.initials: ZX
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D008297:Male; D053511:Matrix Metalloproteinase 14 / Q000032:analysis / Q000096:biosynthesis*; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; C507086:MMP14 protein, human; D053511:Matrix Metalloproteinase 14