title: Nocapyrones: α- and γ-pyrones from a marine-derived Nocardiopsis sp.
abstract: One new α-pyrone (nocapyrone R (1)), and three known γ-pyrones (nocapyrones B, H and L (2-4)) were isolated from the culture extract of a Nocardiopsis strain collected from marine sediment. Structures of these compounds were determined on the basis of spectroscopic data including NMR and MS. γ-Pyrones 2-4 were found to induce adiponectin production in murine ST-13 preadipocyte cells but the α-pyrone 1 had no activity. The absolute configuration of the anteiso-methyl branching in 4 was determined by HPLC comparison of a degraded product of 4 with standard samples as a 2:3 enantiomeric mixture of (R)- and (S)-isomers.
authors.affiliation: Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan. youngju.kim.c@gmail.com.
authors.forename: Youngju
authors.initials: Y
authors.lastname: Kim
authors.affiliation: Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan. qqct6qc9k@blue.ocn.ne.jp.
authors.forename: Hiromu
authors.initials: H
authors.lastname: Ogura
authors.affiliation: Shokei Gakuin University, 4-10-1 Yurigaoka, Natori, Miyagi 981-1295, Japan. akasaka@shokei.ac.jp.
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Akasaka
authors.affiliation: School of Nutrition and Dietetics, Kanagawa University of Human Services, 1-10-1 Heisei-cho, Yokosuka, Kanagawa 238-8566, Japan. oikawa-t@kuhs.ac.jp.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Oikawa
authors.affiliation: Okayama University of Science, 1-1 Ridai-cho, Okayama, Okayama 700-0005, Japan. nobuyasu@dls.ous.ac.jp.
authors.forename: Nobuyasu
authors.initials: N
authors.lastname: Matsuura
authors.affiliation: Tokyo University of Marine Science and Technology, 4-5-7 Konan, Minato-ku, Tokyo 108-8477, Japan. imada@kaiyodai.ac.jp.
authors.forename: Chiaki
authors.initials: C
authors.lastname: Imada
authors.affiliation: Center for Advanced Marine Core Research, Kochi University, B200 Monobe, Nankoku, Kochi 783-8502, Japan. yasuda@kochi-u.ac.jp.
authors.forename: Hisato
authors.initials: H
authors.lastname: Yasuda
authors.affiliation: Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan. yas@pu-toyama.ac.jp.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Igarashi
mesh_terms: D039903:Actinobacteria / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D011753:Pyrones