title: Association of UBQ-8i polymorphism with Alzheimer's disease in Caucasians: a meta-analysis.
abstract: BACKGROUND
  Several studies have reported an association between the UBQ-8i (rs12344615) polymorphism of the UBQLN1 gene and risk of Alzheimer's disease (AD), but these findings remain controversial. In this study, a meta-analysis was carried out to investigate the relationship between UBQ-8i polymorphism and AD risk and a possible synergy with apolipoprotein E (APOE)ε4 gene status.
  
  
  METHODS
  Case-control studies were selected from PubMed, Medline and Embase (Ovid) databases. The potential association was evaluated by odds ratios (ORs) with 95% confidence intervals (CIs). Data were analyzed with Stata version 11.0.
  
  
  RESULTS
  A total of 4679 AD cases and 9928 controls were included in the study. There was no evidence of heterogeneity between studies or publication bias in the meta-analysis. There were no significant differences among the examined genetic models. In the analysis stratified by age of onset, a significant association was detected in the late onset AD group under the allele (OR = 1.12, 95% CI: 1.01-1.24), heterozygote (OR = 1.15, 95% CI: 1.02-1.30) and dominant (OR = 1.13, 95% CI: 1.00-1-26) models. However, UBQ-8i polymorphism was not associated with a higher risk for AD among APOEε4 carriers.
  
  
  CONCLUSIONS
  The results suggest that UBQ-8i polymorphism may contribute to AD susceptibility, but does not synergize with APOEε4 status to increase AD risk.
authors.affiliation: 1Department of Neurosurgery, First Affiliated Hospital of Nanjing Medical University , Nanjing , China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yue
authors.forename: Sen
authors.initials: S
authors.lastname: Wang
authors.forename: Weiping
authors.initials: W
authors.lastname: Yan
authors.forename: Fengyi
authors.initials: F
authors.lastname: Zhu
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics; D000071183:Autophagy-Related Proteins; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D018797:Cell Cycle Proteins / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044465:White People
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D053327:Apolipoprotein E4; D000071183:Autophagy-Related Proteins; D002352:Carrier Proteins; D018797:Cell Cycle Proteins; C107792:UBQLN1 protein, human
keywords: Alzheimer's disease; UBQ-8i; UBQLN1; meta-analysis; polymorphism