title: Novel sustained release and swellable gastroretentive dosage form for ciprofloxacin hydrochloride.
abstract: BACKGROUND
  The present study aims at developing a gastroretentive swellable and floating matrix tablet formulation of ciprofloxacin hydrochloride (HCl) for the effective treatment of infections caused by susceptible organisms. Ciprofloxacin HCl is a fluoroquinoline antibiotic drug. Ciprofloxacin HCl is more stable in acidic medium and it has a narrow absorption window which is sited at the stomach and proximal portions of the small intestine, so it covers the required criteria for selection of drug for gastroretentive dosage form.
  
  
  METHODS
  Ciprofloxacin HCl gastroretentive tablets were formulated by using direct compression method and different grades of hydroxypropyl methylcellulose as suspending and stabilizing agent (polymer), sodium starch glycolate (SSG), crospovidone as disintegrates, sodium bicarbonate as alkalizing agent and magnesium stearate as lubricant.
  
  
  RESULTS
  The tablets were evaluated for post compression parameters. All the parameters were within the pharmacopoeial limits.
  
  
  CONCLUSIONS
  The in vitro dissolution studies showed that the drug release was fast in formulations F2, F4 and F6 containing SSG as super disintegrant when compared with all other formulations. In SEM study of F2 formulation shows maximum swelling and porosity observed after 12 h. Hence, formulation F2 shows the best formulation among the six formulations containing different binders and super disintegrants.
authors.affiliation: Department of Pharmaceutics, Arvind Gavali College of Pharmacy, Jaitapur, Satara, Maharashtra, India.
authors.forename: Vinay Dhananjay
authors.initials: VD
authors.lastname: Gaikwad
authors.affiliation: Department of Pharmaceutics, Arvind Gavali College of Pharmacy, Jaitapur, Satara, Maharashtra, India.
authors.forename: Vishal Dadasaheb
authors.initials: VD
authors.lastname: Yadav
authors.affiliation: Department of Biotechnology, D. Y. Patil College of Science, Pimpri, Pune, Maharashtra, India.
authors.forename: Manish Dhananjay
authors.initials: MD
authors.lastname: Gaikwad
keywords: Ciprofloxacin hydrochloride; direct compression; floating tablet; gastroretentive dosage form