title: A convenient enantioselective decarboxylative aldol reaction to access chiral α-hydroxy esters using β-keto acids.
abstract: We show a convenient decarboxylative aldol process using a scandium catalyst and a PYBOX ligand to generate a series of highly functionalized chiral α-hydroxy esters. The protocol tolerates a broad range of β-keto acids with inactivated aromatic and aliphatic α-keto esters. The possible mechanism is rationalized.
authors.affiliation: School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Duan
authors.affiliation: School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, China ; Institute for Chemistry & Biomedical Sciences, Nanjing University, Nanjing, 210093, China.
authors.forename: Jianlin
authors.initials: J
authors.lastname: Han
authors.affiliation: School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Qian
authors.affiliation: School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, China.
authors.forename: Zirui
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, China ; State of Key Laboratory of Coordination, Nanjing University, Nanjing, 210093, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, China ; State of Key Laboratory of Coordination, Nanjing University, Nanjing, 210093, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Pan
keywords: enantioselective synthesis; hydroxy esters; scandium