title: Nebulized therapy. SEPAR year.
abstract: Inhaled drugs are deposited directly in the respiratory tract. They therefore achieve higher concentrations with faster onset of action and fewer side effects than when used systemically. Nebulized drugs are mainly recommended for patients that require high doses of bronchodilators, when they need to inhale drugs that only exist in this form (antibiotics or dornase alfa) or when they are unable to use other inhalation devices. Technological development in recent years has led to new devices that optimize pulmonary deposits and reduce the time needed for treatment. In this review we focus solely on drugs currently used, or under investigation, for nebulization in adult patients; basically bronchodilators, inhaled steroids, antibiotics, antifungals, mucolytics and others such as anticoagulants, prostanoids and lidocaine.
authors.affiliation: UGC de Enfermedades Respiratorias, Hospital Regional Universitario de Málaga, Instituto de Biomedicina de Málaga (IBIMA), Facultad de Medicina, Universidad de Málaga, Málaga, España. Electronic address: casi1547@separ.es.
authors.forename: Casilda
authors.initials: C
authors.lastname: Olveira
authors.affiliation: UGC de Enfermedades Respiratorias, Hospital Regional Universitario de Málaga, Málaga, España.
authors.forename: Ana
authors.initials: A
authors.lastname: Muñoz
authors.affiliation: UGC de Enfermedades Respiratorias, Hospital Regional Universitario de Málaga, Málaga, España.
authors.forename: Adolfo
authors.initials: A
authors.lastname: Domenech
mesh_terms: D000280:Administration, Inhalation; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage; D001987:Bronchiectasis / Q000188:drug therapy; D001993:Bronchodilator Agents / Q000008:administration & dosage; D003550:Cystic Fibrosis / Q000188:drug therapy; D004867:Equipment Design; D005100:Expectorants / Q000008:administration & dosage; D006801:Humans; D009330:Nebulizers and Vaporizers; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy; D016032:Randomized Controlled Trials as Topic; D019141:Respiratory System Agents / Q000008:administration & dosage*; D012141:Respiratory Tract Infections / Q000188:drug therapy
chemical_list: D000305:Adrenal Cortex Hormones; D000890:Anti-Infective Agents; D001993:Bronchodilator Agents; D005100:Expectorants; D019141:Respiratory System Agents
keywords: Antibióticos nebulizados; Bronchodilators; Broncodilatadores; Mucolíticos nebulizados; Nebulizadores; Nebulized antibiotics; Nebulized mucolytics; Nebulized therapy; Nebulizers; Terapia nebulizada