title: [Immune function of interleukin-33 and its relation to human diseases].
abstract: Interleukin-33 (IL-33) is a novel cytokine and belongs to IL-1 family expressed in a wide range of organs and cells. IL-33 is a dual-functional molecule: as a classical cytokine it induces immune response and it also regulates gene transcription in the nucleus. Altered expression of IL-33 has been observed in various human diseases such as inflammation, autoimmune diseases, and virus infection. The article reviews advances on immune function of IL-33 and its relation to a variety of human diseases.
authors.affiliation: Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.
authors.forename: Bi-jun
authors.initials: BJ
authors.lastname: Cui
authors.affiliation: Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.
authors.forename: Qing-qing
authors.initials: QQ
authors.lastname: Wang
mesh_terms: D001327:Autoimmune Diseases / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology; D000067596:Interleukin-33; D007378:Interleukins / Q000276:immunology*
chemical_list: C506536:IL33 protein, human; D000067596:Interleukin-33; D007378:Interleukins