title: PML, SUMO, and RNF4: guardians of nuclear protein quality.
abstract: In this issue of Molecular Cell, Guo et al. (2014) report that misfolded or aggregated nuclear proteins, such as pathogenic polyQ proteins, are cleared by a SUMO-dependent quality control pathway, which involves the E3 SUMO ligase PML and the SUMO-targeted ubiquitin ligase RNF4.
authors.affiliation: Institute of Biochemistry II, Goethe University, Faculty of Medicine, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
authors.forename: Anne
authors.initials: A
authors.lastname: Gärtner
authors.affiliation: Institute of Biochemistry II, Goethe University, Faculty of Medicine, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany. Electronic address: ste.mueller@em.uni-frankfurt.de.
authors.forename: Stefan
authors.initials: S
authors.lastname: Muller
mesh_terms: D000818:Animals; D006801:Humans; D009410:Nerve Degeneration / Q000473:pathology*; D017510:Protein Folding; D059748:Proteolysis