title: Meningoencephalitis in a dog due to Trichosporon montevideense.
abstract: Meningoencephalitis due to infection with Trichosporon montevideense was diagnosed in a 4-year-old dog with a brief clinical history of rapidly progressing neurological signs that culminated in a comatose state. No significant gross lesions were found at post-mortem examination. Microscopically, a few scattered areas of pyogranulomatous inflammation with a few small, non-pigmented fungal hyphae were found within the cerebrum surrounding the lateral ventricles. A Trichosporon sp. was identified through culture of the brain and species was determined via sequence analysis of the internal transcribed spacer region of the Trichosporon rRNA gene. DNA in-situ hybridization confirmed the diagnosis. This is the first reported case of Trichosporon-associated meningoencephalitis in a dog.
authors.affiliation: Department of Veterinary Pathobiology, Texas A&M University, College Station, TX, USA. Electronic address: lbryan@cvm.tamu.edu.
authors.forename: L K
authors.initials: LK
authors.lastname: Bryan
authors.affiliation: Department of Veterinary Pathobiology, Texas A&M University, College Station, TX, USA.
authors.forename: B F
authors.initials: BF
authors.lastname: Porter
authors.affiliation: Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
authors.forename: B L
authors.initials: BL
authors.lastname: Wickes
authors.affiliation: Department of Large Animal Clinical Sciences, Texas A&M University, College Station, TX, USA.
authors.forename: K A
authors.initials: KA
authors.lastname: Spaulding
authors.affiliation: Department of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, USA.
authors.forename: S C
authors.initials: SC
authors.lastname: Kerwin
authors.affiliation: Department of Veterinary Pathobiology, Texas A&M University, College Station, TX, USA.
authors.forename: S D
authors.initials: SD
authors.lastname: Lawhon
mesh_terms: D000818:Animals; D004285:Dogs; D005260:Female; D017403:In Situ Hybridization; D008590:Meningoencephalitis / Q000382:microbiology / Q000662:veterinary*; D014250:Trichosporon; D060586:Trichosporonosis / Q000662:veterinary*
keywords: Trichosporon montevideense; dog; in-situ hybridization; meningoencephalitis