title: Olanzapine-induced neuroleptic malignant syndrome in a patient with bipolar affective disorder: Does quetiapine holds the solution?
abstract: Neuroleptic Malignant Syndrome (NMS) is a rare, severe and life threatening condition induced by antipsychotic medications. It is commonly encountered with the use of first generation antipsychotics, however cases of NMS have been reported with the use of second generation antipsychotics like Olanzapine, Risperidone, Paliperidone, Aripiprazole, Ziprasidone, Amisulpride, Quetiapine and Clozapine, though the incidence of such reports is rare. Due to decreased use of first generation antipsychotics, NMS is reported less frequently now a days. In this case report- we highlight the management issues of a patient suffering from bipolar affective disorder, who had developed NMS following intramuscular injection of haloperidol, which was withdrawn and olanzapine was given later on. The patient had again developed NMS with olanzapine. Finally the patient was managed with modified electroconvulsive therapy and discharged on Lithium carbonate and Quetiapine.
authors.affiliation: Department of Psychiatry, Institute of Human Behavior and Allied Sciences, Delhi, India.
authors.forename: Praveen
authors.initials: P
authors.lastname: Tripathi
authors.affiliation: Department of Psychiatry, Institute of Human Behavior and Allied Sciences, Delhi, India.
authors.forename: Hemika
authors.initials: H
authors.lastname: Agrawal
authors.affiliation: Department of Psychiatry, Institute of Human Behavior and Allied Sciences, Delhi, India.
authors.forename: Priyanka
authors.initials: P
authors.lastname: Goyal
authors.affiliation: Department of Psychiatry, King George's Medical University, Lucknow, Uttar Pradesh, India.
authors.forename: Sujita Kumar
authors.initials: SK
authors.lastname: Kar
keywords: Bipolar affective disorder; haloperidol; neuroleptic malignant syndrome; olanzapine