title: Interleukin 17 expression in peripheral blood neutrophils from fungal keratitis patients and healthy cohorts in southern India.
abstract: Interleukin 17A (IL-17) production by peripheral blood neutrophils was examined in patients with fungal keratitis and in uninfected individuals in southern India, which has high levels of airborne Aspergillus and Fusarium conidia. Il17a gene expression and intracellular IL-17 were detected in all groups, although levels were significantly elevated in neutrophils from patients with keratitis. There were no significant differences in plasma IL-17 and IL-23 between patients with keratitis and uninfected individuals; however, combined data from all groups showed a correlation between the percentage IL-17 producing neutrophils and plasma IL-23, and between plasma IL-17 and IL-6 and IL-23.
authors.affiliation: Dr G. Venkatasamy Eye Research Institute, Aravind Eye Hospital, Tamil Nadu, India.
authors.forename: Rajapandian Sivaganesa
authors.initials: RS
authors.lastname: Karthikeyan
authors.affiliation: Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio.
authors.forename: Chairut
authors.initials: C
authors.lastname: Vareechon
authors.affiliation: Dr G. Venkatasamy Eye Research Institute, Aravind Eye Hospital, Tamil Nadu, India.
authors.forename: Namperumalsamy Venkatesh
authors.initials: NV
authors.lastname: Prajna
authors.affiliation: Dr G. Venkatasamy Eye Research Institute, Aravind Eye Hospital, Tamil Nadu, India.
authors.forename: Kuppamuthu
authors.initials: K
authors.lastname: Dharmalingam
authors.affiliation: Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio.
authors.forename: Eric
authors.initials: E
authors.lastname: Pearlman
authors.affiliation: Dr G. Venkatasamy Eye Research Institute, Aravind Eye Hospital, Tamil Nadu, India.
authors.forename: Prajna
authors.initials: P
authors.lastname: Lalitha
mesh_terms: D000328:Adult; D001228:Aspergillosis / Q000235:genetics / Q000276:immunology / Q000382:microbiology; D001230:Aspergillus / Q000276:immunology; D016022:Case-Control Studies; D015331:Cohort Studies; D015821:Eye Infections, Fungal / Q000097:blood* / Q000276:immunology / Q000382:microbiology*; D060585:Fusariosis / Q000097:blood / Q000235:genetics / Q000276:immunology / Q000382:microbiology; D005670:Fusarium / Q000276:immunology; D006801:Humans; D007194:India; D020381:Interleukin-17 / Q000096:biosynthesis* / Q000097:blood / Q000235:genetics; D053759:Interleukin-23 / Q000096:biosynthesis / Q000097:blood / Q000235:genetics; D015850:Interleukin-6 / Q000096:biosynthesis / Q000097:blood / Q000235:genetics / Q000276:immunology; D007634:Keratitis / Q000097:blood* / Q000235:genetics / Q000276:immunology / Q000382:microbiology*; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology*
chemical_list: D020381:Interleukin-17; D053759:Interleukin-23; D015850:Interleukin-6
keywords: Aspergillus; Fusarium; IL-17; IL-23; corneal ulcer; fungal infection; keratitis; neutrophil