title: Seasonal changes in antibiotics, antidepressants/psychiatric drugs, antihistamines and lipid regulators in a wastewater treatment plant.
abstract: Seasonal changes in the concentration of 21 pharmaceuticals in a wastewater treatment plant (WWTP) in České Budějovice were investigated over 12months. The target compounds were 10 antibiotics, 4 antidepressants, 3 psychiatric drugs, 2 antihistamines and 2 lipid regulators. 272 Wastewater samples (136 influents and 136 effluents) were collected from March 2011 to February 2012 and analyzed using two-dimensional liquid chromatography coupled with tandem mass spectrometry. All studied pharmaceuticals were frequently detected in both the influent and the effluent wastewater samples, except for meclozine, which was only found in the influent. The mean concentration of pharmaceuticals varied from 0.006μgL(-1) to 1.48μgL(-1) in the influent and from 0.003μgL(-1) to 0.93μgL(-1) in the effluent. The concentration of most pharmaceuticals was higher during winter.
authors.affiliation: University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Zatisi 728/II, 389 25 Vodnany, Czech Republic. Electronic address: ogolovko@frov.jcu.cz.
authors.forename: Oksana
authors.initials: O
authors.lastname: Golovko
authors.affiliation: University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Zatisi 728/II, 389 25 Vodnany, Czech Republic. Electronic address: vkumar@frov.jcu.cz.
authors.forename: Vimal
authors.initials: V
authors.lastname: Kumar
authors.affiliation: University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Zatisi 728/II, 389 25 Vodnany, Czech Republic. Electronic address: fedorg00@frov.jcu.cz.
authors.forename: Ganna
authors.initials: G
authors.lastname: Fedorova
authors.affiliation: University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Zatisi 728/II, 389 25 Vodnany, Czech Republic. Electronic address: randak@vurh.jcu.cz.
authors.forename: Tomas
authors.initials: T
authors.lastname: Randak
authors.affiliation: University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Zatisi 728/II, 389 25 Vodnany, Czech Republic. Electronic address: rgrabic@frov.jcu.cz.
authors.forename: Roman
authors.initials: R
authors.lastname: Grabic
mesh_terms: D000900:Anti-Bacterial Agents / Q000032:analysis / Q000737:chemistry; D000928:Antidepressive Agents / Q000032:analysis / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D006633:Histamine Antagonists / Q000032:analysis / Q000737:chemistry; D000960:Hypolipidemic Agents / Q000032:analysis / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000032:analysis / Q000737:chemistry*; D012621:Seasons; D053719:Tandem Mass Spectrometry; D064091:Waste Disposal Facilities; D014865:Waste Disposal, Fluid; D062065:Wastewater / Q000032:analysis / Q000737:chemistry*; D014874:Water Pollutants, Chemical / Q000032:analysis* / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D000928:Antidepressive Agents; D006633:Histamine Antagonists; D000960:Hypolipidemic Agents; D004364:Pharmaceutical Preparations; D062065:Wastewater; D014874:Water Pollutants, Chemical
keywords: Effluent; Influent; Personal care products; Removal efficiency; Seasonal variation; Wastewater samples