title: Serum concentration of sialic acids in naturally occurring ovine babesiosis.
abstract: This study is designated to assess the effect of the severity of Babesia ovis infection on sialic acid concentration in blood sera in naturally infected sheep. Infected animals (diseased group) comprised 38 Iranian fat-tailed sheep, about 1-3 years old, naturally infected with B. ovis, divided into four subgroups with respect to parasitemia rates (low 0.1-0.3 %, moderate 0.4-0.9 %, high 1-2.5 %, and very high >2.5 %). The parasitological diagnosis was confirmed using PCR analysis. As a control group, ten clinically healthy sheep reared under the same management and environmental conditions were also sampled. Hematological parameters and the concentrations of total sialic acid (TSA), lipid-bound sialic acid (LBSA), and protein-bound sialic acid (PBSA) were measured in both groups. Compared to controls, sialic acid concentrations showed significant increase (p < 0.05) in infected sheep. Parasitemia rate was positively correlated with sialic acid concentrations. This study demonstrated that B. ovis infection induced marked and persistent elevations of serum sialic acid concentrations. It seems that increase of serum sialic acid concentrations during parasitemia alter receptor-ligand interactions, which are known to play important role in immune response. Furthermore, sialic acid would indirectly inhibit the action of leukocytes and consequently promote the evasion of the immune response and persistence of the parasite in the host. This factor could influence the parasite-host cell adhesion, but further detailed biochemical investigations are needed to precisely explain the exact role of sialic acid in invasion process of the parasite to the host cells.
authors.affiliation: Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran, b_esmaeilnejad@yahoo.com.
authors.forename: Bijan
authors.initials: B
authors.lastname: Esmaeilnejad
authors.forename: Mousa
authors.initials: M
authors.lastname: Tavassoli
authors.forename: Siamak
authors.initials: S
authors.lastname: Asri-Rezaei
authors.forename: Bahram
authors.initials: B
authors.lastname: Dalir-Naghadeh
authors.forename: Seyyed Meysam
authors.initials: SM
authors.lastname: Abtahi Froushani
authors.forename: Jafar
authors.initials: J
authors.lastname: Arjmand
authors.forename: Mostafa
authors.initials: M
authors.lastname: Golabi
mesh_terms: D000818:Animals; D001403:Babesia / Q000235:genetics; D001404:Babesiosis / Q000097:blood* / Q000453:epidemiology; D007492:Iran / Q000453:epidemiology; D018512:Parasitemia / Q000453:epidemiology / Q000662:veterinary*; D016133:Polymerase Chain Reaction / Q000662:veterinary; D012756:Sheep; D012757:Sheep Diseases / Q000097:blood* / Q000453:epidemiology / Q000469:parasitology*; D034561:Sheep, Domestic; D012794:Sialic Acids / Q000097:blood*; D018709:Statistics, Nonparametric
chemical_list: D012794:Sialic Acids