title: E-selectin gene polymorphisms and essential hypertension in Asian population: an updated meta-analysis.
abstract: OBJECTIVE
  Epidemiological studies have shown that E-selectin gene polymorphisms (A561C and C1839T) may be associated with essential hypertension (EH), but the results are conflicting in different ethnic populations. Thus, we performed this meta-analysis to investigate a more authentic association between E-selectin gene polymorphisms and the risk of EH.
  
  
  METHODS
  We searched the relevant studies for the present meta-analysis from the following electronic databases: PubMed, Embase, Cochrane Library, Google Scholar, Web of Science, Wanfang Data, and China National Knowledge Infrastructure (CNKI). Odds ratios (OR) with 95% confidence interval (CI) were used to evaluate the strength of the association between E-selectin gene polymorphisms and EH susceptibility. The pooled ORs were performed for dominant model, allelic model and recessive model. The publication bias was examined by Begg's funnel plots and Egger's test.
  
  
  RESULTS
  A total of eleven studies met the inclusion criteria. All studies came from Asians. Ten studies (12 cohorts) evaluated the A561C polymorphism and EH risk, including 2,813 cases and 2,817 controls. The pooled OR was 2.280 (95%CI: 1.893-2.748, P<0.001) in dominant model, 5.284 (95%CI: 2.679-10.420, P<0.001) in recessive model and 2.359 (95%CI: 1.981-2.808, P = 0.001) in allelic model. Four studies (six cohorts) evaluated C1839T polymorphism and EH risk, including 1,700 cases and 1,681 controls. The pooled OR was 0.785 (95%CI: 0.627-0.983, P = 0.035) in dominant model, 1.250 (95%CI: 0.336-4.652, P = 0.739) in recessive model and 0.805 (95%CI: 0.649-0.999, P = 0.049) in allelic model.
  
  
  CONCLUSIONS
  The current meta-analysis concludes that the C allele of E-selectin A561C gene polymorphism might increase the EH risk in Asian population, whereas the T allele of E-selectin C1839T gene polymorphism might decrease the EH risk.
authors.affiliation: Department of Cardiology, Wujin hospital affiliated to Jiangsu University, Changzhou, Jiangsu Province, China.
authors.forename: Gaojun
authors.initials: G
authors.lastname: Cai
authors.affiliation: Department of Pathology and Molecular Medicine, McMaster University, Ontario, Canada.
authors.forename: Bifeng
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Wujin hospital affiliated to Jiangsu University, Changzhou, Jiangsu Province, China.
authors.forename: Weijin
authors.initials: W
authors.lastname: Weng
authors.affiliation: Department of Cardiology, Wujin hospital affiliated to Jiangsu University, Changzhou, Jiangsu Province, China.
authors.forename: Ganwei
authors.initials: G
authors.lastname: Shi
authors.affiliation: Department of Cardiology, Wujin hospital affiliated to Jiangsu University, Changzhou, Jiangsu Province, China.
authors.forename: Sheliang
authors.initials: S
authors.lastname: Xue
authors.affiliation: Department of Cardiology, Wujin hospital affiliated to Jiangsu University, Changzhou, Jiangsu Province, China.
authors.forename: Yanbin
authors.initials: Y
authors.lastname: Song
authors.affiliation: Department of Cardiology, Wujin hospital affiliated to Jiangsu University, Changzhou, Jiangsu Province, China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Ma
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D019040:E-Selectin / Q000235:genetics*; D000075222:Essential Hypertension; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D019040:E-Selectin