title: Addressing the burden of neonatal hyperbilirubinaemia in countries with significant glucose-6-phosphate dehydrogenase deficiency.
abstract: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an established worldwide risk factor for severe hyperbilirubinaemia. This literature review examined the pattern and management of severe hyperbilirubinaemia in low- and middle-income countries (LMICs) where G6PD deficiency was 10% or more and found that it was frequently associated with neonatal mortality and, or, neurodevelopmental disorders.
  
  
  CONCLUSIONS
  Low- and middle-income countries need to pay urgent attention to G6PD deficiency to curtail the preventable burden of jaundice-related morbidity, mortality and disability.
authors.affiliation: Centre for Healthy Start Initiative, Ikoyi, Lagos, Nigeria.
authors.forename: Bolajoko O
authors.initials: BO
authors.lastname: Olusanya
authors.affiliation: Massey Street Children's Hospital, Lagos, Nigeria.
authors.forename: Abieyuwa A
authors.initials: AA
authors.lastname: Emokpae
authors.affiliation: Department of Paediatrics, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Tara G
authors.initials: TG
authors.lastname: Zamora
authors.affiliation: Department of Paediatrics, University of Minnesota & Hennepin County Medical Center, Minneapolis, MN, USA.
authors.forename: Tina M
authors.initials: TM
authors.lastname: Slusher
mesh_terms: D017281:Cost of Illness; D003906:Developing Countries; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications*; D006801:Humans; D051556:Hyperbilirubinemia, Neonatal / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D015994:Incidence; D007231:Infant, Newborn; D011203:Poverty; D012720:Severity of Illness Index
keywords: Acute bilirubin encephalopathy; Child disability; Developing countries; Kernicterus; Phototherapy