title: [Association between interleukin-18 and Global Registry of Acute Coronary Events score in patients with acute coronary syndrome].
abstract: OBJECTIVE
  To determine the correlation between interleukin-18 (IL-18) level and Global Registry of Acute Coronary Events (GRACE) risk score as well as risk stratification in patients with acute coronary syndrome (ACS), and to determine the clinical prognostic value of IL-18 for major adverse cardiac events (MACE) in ACS patients.
  
  
  METHODS
  A total of 150 ACS patients were subjected to risk assessment and stratification with GRACE risk score. All ACS patients received conventional treatments and MACE was recorded. Plasma IL-18 was measured by enzyme-linked immunosorbent assay and the relationship between plasma IL-18 level and GRACE scores in ACS patients was analyzed. Predictive accuracy of IL-18 level and GRACE risk score for MACE were determined by receiver operating characteristic curve and the corresponding area under the curve.
  
  
  RESULTS
  According to GRACE risk stratification, IL-18 level was significantly elevated in the high risk group (>140) compared with that in the middle risk group (109-140; P<0. 05), while IL-18 level was significantly elevated in the middle risk group compared with that in the low risk group (≤108; P<0. 05). According to the IL-18 level, patients were stratified into 4 groups by quartile (from the lowest to the highest, Q1-Q4). Compared with Q1-Q3 groups, the GRACE risk score and percentage of high risk patients were the highest in the Q4 group (P<0.05). Receiver operating characteristic curve analysis showed that IL-18 level was positively related with GRACE risk score and that the area under the curve of IL-18 level and GRACE risk score for predicting MACE in hospital patients were 0.887 and 0.914, respectively.
  
  
  CONCLUSIONS
  Both IL-18 level and GRACE risk score are valuable parameters for risk of MACE in patients with ACS. IL-18 may be an important biomarker in the prognosis of ACS patients.
authors.affiliation: Department of Cardiology, Xiangya Hospital, Central South University, Changsha 410008,China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhou
authors.forename: Guiyuan
authors.initials: G
authors.lastname: Deng
authors.forename: Tianlun
authors.initials: T
authors.lastname: Yang
authors.forename: Qilin
authors.initials: Q
authors.lastname: Ma
authors.forename: Xiuju
authors.initials: X
authors.lastname: Luo
mesh_terms: D054058:Acute Coronary Syndrome / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D020382:Interleukin-18 / Q000097:blood*; D011379:Prognosis; D012372:ROC Curve; D018570:Risk Assessment; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D020382:Interleukin-18