title: No association between the SOCS-1 -1478CA/del polymorphism and ulcerative colitis in Turkish subjects.
abstract: Suppressor of cytokine signaling (SOCS)-1 is an essential regulator of many cytokine signaling pathways, including those upregulated in the inflamed colonic mucosa of patients with ulcerative colitis. We sought to investigate whether the functional SOCS-1 -1478CA>del polymorphism is associated with UC susceptibility and its disease phenotype in a Turkish clinical sample. A total of 104 subjects were enrolled in a case-control study (52 UC cases and 52 controls). The SOCS-1 -1478CA>del polymorphism was genotyped using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The odds ratio of the del allele for UC relative to the CA allele was not significant (OR = 1.04, 95 % CI 0.59-1.82, P = 0.88). These results did not change after adjustment for age and sex in multivariable regression analysis (OR = 1.07, 95 % CI 0.42-1.69, P = 0.73). When the SOCS-1 -1478CA>del polymorphism was analyzed among UC patients according to continuous disease and non-continuous disease, the del allele was not associated with disease recurrence (OR = 1.56, 95 % CI 0.78-4.56, P = 0.83). Furthermore, when we divided UC patients into two groups according to a previous history of colectomy, we found no significant effect of the del allele (OR = 1.94, 95 % CI 0.55-5.61, P = 0.91). Taken together, these findings suggest that SOCS-1 -1478CA>del polymorphism does not contribute to UC susceptibility and its disease phenotype in Turkish subjects.
authors.affiliation: Department of Internal Medicine, Uludag University, 16059, Bursa, Turkey, hartavimustafa@gmail.com.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Hartavi
authors.forename: Selim Giray
authors.initials: SG
authors.lastname: Nak
authors.forename: Barbaros
authors.initials: B
authors.lastname: Oral
authors.forename: Adem
authors.initials: A
authors.lastname: Deligönül
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D000071222:Suppressor of Cytokine Signaling 1 Protein; D050826:Suppressor of Cytokine Signaling Proteins / Q000235:genetics*; D014421:Turkey; D055815:Young Adult
chemical_list: C108944:SOCS1 protein, human; D000071222:Suppressor of Cytokine Signaling 1 Protein; D050826:Suppressor of Cytokine Signaling Proteins