title: Palladium-catalyzed decarboxylative allylic alkylation of diastereomeric β-ketoesters.
abstract: The palladium-catalyzed decarboxylative allylic alkylation of diastereomeric β-ketoesters derived from 4-tert-butylcyclohexanone is described. These experiments were performed to elucidate our understanding of stereoablative enantioconvergent catalysis. A detailed analysis of the product distribution, including stereochemical outcome of the products, is included. These studies also reveal an interesting example of selectivity that is governed by competing modes of substrate and catalyst control.
authors.affiliation: Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, United States.
authors.forename: Sandy
authors.initials: S
authors.lastname: Ma
authors.affiliation: Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, United States.
authors.forename: Corey M
authors.initials: CM
authors.lastname: Reeves
authors.affiliation: Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, United States.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Craig
authors.affiliation: Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, United States.
authors.forename: Brian M
authors.initials: BM
authors.lastname: Stoltz
keywords: Alkylation; Allylic; Decarboxylative; Ketoesters; Palladium