title: Effects of Aloe vera leaf gel extract on rat peritonitis model.
abstract: OBJECTIVE
  The aim of this study was to investigate the antibacterial, anti-inflammatory, and antioxidant activities and probable toxic effects of Aloe vera (AV) in a rat peritonitis model.
  
  
  METHODS
  RATS WERE DIVIDED INTO FIVE GROUPS: (1) Control group, (2) AV group, (3) peritonitis group (P), (4) peritonitis + AV group (P + AV), and (5) peritonitis + antibiotherapy group (P + Ab). Ultrafiltration (UF) rates were determined and colony and leukocyte counts were calculated in the dialysate. Glucose, blood urea nitrogen (BUN), creatinine levels, and alanine transaminase (ALT) activities were studied in blood. Glucose, interleukins (IL-1β, IL-6), and prostaglandin E2 (PGE2) were studied in dialysate and peritoneal tissue for the assessment of the anti-inflammatory effect. Copper/zinc superoxide dismutase (Cu, Zn-SOD), malondialdehyde (MDA), and nitric oxide (NO) were also investigated in peritoneal tissue.
  
  
  RESULTS
  Aloe vera increased the UF rate and lowered leukocyte numbers in the peritonitis group. There was no significant difference in blood and dialysate glucose, BUN, creatinine levels and ALT activity among control and AV groups. AV decreased IL-1β, IL-6 and PGE2 in peritonitis, showing good anti-inflammatory effect. AV showed antioxidant effect on the chosen antioxidant parameters Cu, Zn-SOD, MDA, and NO.
  
  
  CONCLUSIONS
  It was concluded that, AV might be used in peritonitis for its probable UF increasing, anti-inflammatory, and antioxidant effects.
authors.affiliation: Departments of Pediatrics, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey.
authors.forename: Ayca
authors.initials: A
authors.lastname: Altincik
authors.affiliation: Division of Pediatric Nephrology, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey.
authors.forename: Ferah
authors.initials: F
authors.lastname: Sönmez
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey.
authors.forename: Cigdem
authors.initials: C
authors.lastname: Yenisey
authors.affiliation: Department of Internal Medicine, Division of Nephrology, İzmir, Turkey.
authors.forename: Soner
authors.initials: S
authors.lastname: Duman
authors.affiliation: Department of Biochemistry, Faculty of Pharmacy, İstanbul University, İstanbul, Turkey.
authors.forename: Ayse
authors.initials: A
authors.lastname: Can
authors.affiliation: Department of Biochemistry, Faculty of Pharmacy, İstanbul University, İstanbul, Turkey.
authors.forename: Nuriye
authors.initials: N
authors.lastname: Akev
authors.affiliation: Department of Microbiology, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey.
authors.forename: Sevin
authors.initials: S
authors.lastname: Kirdar
authors.affiliation: Department of Pathology, Faculty of Medicine, Ege University, İzmir, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Sezak
mesh_terms: D000504:Aloe; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D058491:Bacterial Load; D015314:Dialysis Solutions / Q000378:metabolism; D015232:Dinoprostone / Q000378:metabolism; D004195:Disease Models, Animal; D005782:Gels; D053583:Interleukin-1beta / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D007958:Leukocyte Count; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D010537:Peritoneum / Q000378:metabolism; D010538:Peritonitis / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D018515:Plant Leaves; D028321:Plant Preparations / Q000494:pharmacology / Q000627:therapeutic use*; D017208:Rats, Wistar; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D013211:Staphylococcus aureus / Q000302:isolation & purification; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: C586178:Aloe vera gel; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D015314:Dialysis Solutions; D005782:Gels; D053583:Interleukin-1beta; D015850:Interleukin-6; D028321:Plant Preparations; D009569:Nitric Oxide; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D015232:Dinoprostone
keywords: Aloe vera; antioxidant enzymes; cytokines; peritonitis; ultrafiltration