title: Mucocutaneous granulomatous disease in a patient with Hermansky-Pudlak syndrome.
abstract: OBJECTIVE
  Hermansky-Pudlak syndrome (HPS) is a rare genodermatosis characterized by oculocutaneous albinism, platelet dysfunction, and in some patients, pulmonary fibrosis and granulomatous colitis. The granulomatous inflammation in the bowel of patients with HPS can be indistinguishable clinically and histologically from that of Crohn disease (CD); however, mucocutaneous granulomatous lesions have not been considered among the typical skin findings of HPS.
  
  
  METHODS
  We report a case of an albino woman in her 40s with a history of CD and pulmonary fibrosis who presented with ulcers, plaques, and nodules in the vulva, perineum, inguinal creases, and left axilla. These cutaneous findings had the typical clinical and histologic findings of metastatic cutaneous CD. However, she also had a genetically confirmed diagnosis of HPS.
  
  
  CONCLUSIONS
  It is unclear whether our patient's cutaneous findings were due to CD or secondary to HPS. This report reviews the features of HPS and CD, 2 entities characterized by a granulomatous inflammatory reaction pattern but with unique genetic and clinical features, and discusses the possible overlap between the 2 diagnoses.
authors.affiliation: Bassett Healthcare Network, Oneonta, New York.
authors.forename: Heather L
authors.initials: HL
authors.lastname: Salvaggio
authors.affiliation: Penn State College of Medicine, Hershey, Pennsylvania.
authors.forename: Kristen E
authors.initials: KE
authors.lastname: Graeber
authors.affiliation: Dermatology Unit, Myriad Genetics Inc, Salt Lake City, Utah.
authors.forename: Loren E
authors.initials: LE
authors.lastname: Clarke
authors.affiliation: Department of Dermatology, Northwestern University, Chicago, Illinois5Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois.
authors.forename: Bethanee J
authors.initials: BJ
authors.lastname: Schlosser
authors.affiliation: Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York.
authors.forename: Seth J
authors.initials: SJ
authors.lastname: Orlow
authors.affiliation: Penn State Hershey Medical Center, Hershey, Pennsylvania.
authors.forename: Jennie T
authors.initials: JT
authors.lastname: Clarke
mesh_terms: D000328:Adult; D001365:Axilla; D003424:Crohn Disease / Q000150:complications*; D005260:Female; D006099:Granuloma / Q000209:etiology* / Q000628:therapy; D006119:Groin; D022861:Hermanski-Pudlak Syndrome / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D009092:Mucous Membrane; D010502:Perineum; D014845:Vulvar Diseases / Q000209:etiology / Q000628:therapy