title: [hMSH2 aberrant expression in patients with sporadic colorectal cancer in Xinjiang].
abstract: OBJECTIVE
  To explore the significance of hMSH2 aberrant expression in patients with sporadic colorectal cancer in Xinjiang Uygur Autonomous Region.
  
  
  METHODS
  Clinicopathological parameters and postoperative samples of 327 patients with sporadic colorectal cancer were collected in Xinjiang Uygur Autonomous Region. Immunohistochemistry PV-9000 two-step method was performed to measure hMSH2 expression in the postoperative pathologic specimens. Prognostic value of hMSH2 expression was evaluated.
  
  
  RESULTS
  Thirty-five (10.7%) patients showed aberrant nuclear staining of hMSH2 expression. The patients with aberrant expression of hMSH2 showed better prognosis than the normal expression group, with significant difference (P<0.05).
  
  
  CONCLUSIONS
  In Xinjiang, aberrant hMSH2 expression can be regarded as an independent prognostic factor in patients with sporadic colorectal cancer.
authors.affiliation: Department of Blood, Enterology and Endocrinology, Chinese PLA 474 Hospital, Urumqi 830011,China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Wang
authors.forename: Zhenqiang
authors.initials: Z
authors.lastname: Sun
authors.forename: Ligong
authors.initials: L
authors.lastname: Ye
authors.forename: Pei
authors.initials: P
authors.lastname: Xu
authors.forename: Yunxia
authors.initials: Y
authors.lastname: Zhao
authors.forename: Lina
authors.initials: L
authors.lastname: Tang
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Dun
mesh_terms: D015179:Colorectal Neoplasms / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D051718:MutS Homolog 2 Protein / Q000235:genetics / Q000378:metabolism*; D011379:Prognosis
chemical_list: C497172:MSH2 protein, human; D051718:MutS Homolog 2 Protein