title: [The low-molecular weight antioxidants of microorganisms].
abstract: Support of optimum redox-homeostasis in the cells of microorganisms plays a substantial role in the processes of DNA synthesis, respiration, providing of immune and protective reactions, activity of enzymes, etc. The changes of the redox-status can be accompanied by the increase of the level of reactive oxygen species (ROS) which predetermine the damage of biologically active molecules. Adjusting of ROS concentrations is a very important process in development of microorganisms. Low-molecular antioxidants are effective inhibitors of free-radical processes. The authors of the review present the description of oxidants and consider the ways of origin and consequences of their influence on the living cells. An accent is done on phenomenological description of low-molecular antioxidants. The basic mechanisms of their action are considered. Special attention is given to the question of synergism between these protectors. The detailed study of mechanisms of functioning of low-molecular antioxidants in the cells of microorganisms will allow using these living objects in different spheres of human activity.
authors.forename: I O
authors.initials: IO
authors.lastname: Skorokhod
authors.forename: I K
authors.initials: IK
authors.lastname: Kurdysh
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D000975:Antioxidants / Q000378:metabolism*; D001419:Bacteria / Q000378:metabolism*; D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism; D002338:Carotenoids / Q000378:metabolism; D004249:DNA Damage; D004269:DNA, Bacterial / Q000737:chemistry / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism; D015227:Lipid Peroxidation; D008668:Metallothionein / Q000378:metabolism; D010084:Oxidation-Reduction; D010636:Phenols / Q000378:metabolism; D011073:Polyamines / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors* / Q000378:metabolism; D014815:Vitamins / Q000378:metabolism
chemical_list: D000596:Amino Acids; D000975:Antioxidants; D001426:Bacterial Proteins; D004269:DNA, Bacterial; D010636:Phenols; D011073:Polyamines; D017382:Reactive Oxygen Species; D014815:Vitamins; D002338:Carotenoids; D008668:Metallothionein; D005978:Glutathione