title: A protocol to generate phthaloyl peroxide in flow for the hydroxylation of arenes.
abstract: A flow protocol for the generation of phthaloyl peroxide has been developed. This process directly yields phthaloyl peroxide in high purity (>95%) and can be used to bypass the need to isolate and recrystallize phthaloyl peroxide, improving upon earlier batch procedures. The flow protocol for the formation of phthaloyl peroxide can be combined with arene hydroxylation reactions and provides a method for the consumption of peroxide as it is generated to minimize the accumulation of large quantities of peroxide.
authors.affiliation: Department of Chemistry, The University of Texas at Austin , 1 University Station, Austin, Texas 78712, United States.
authors.forename: Anders M
authors.initials: AM
authors.lastname: Eliasen
authors.forename: Randal P
authors.initials: RP
authors.lastname: Thedford
authors.forename: Karin R
authors.initials: KR
authors.lastname: Claussen
authors.forename: Changxia
authors.initials: C
authors.lastname: Yuan
authors.forename: Dionicio
authors.initials: D
authors.lastname: Siegel
mesh_terms: D006900:Hydroxylation; D015394:Molecular Structure; D010545:Peroxides / Q000138:chemical synthesis* / Q000737:chemistry; D010795:Phthalic Acids / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D010545:Peroxides; D010795:Phthalic Acids; C000596643:phthaloyl peroxide