title: Foodomics for healthy nutrition.
abstract: OBJECTIVE
  To understand how the principles of foodomics could improve the assessment of the nutritional status and needs.
  
  
  RESULTS
  The knowledge that metabolic pathways may be altered in individuals with genetic variants in the presence of certain dietary exposures offers great potential for personalized nutrition advice, and epigenetics and nutrigenetics have been used to assess the need and status of specific nutrients. MicroRNAs profiling and genome-wide association studies have also contributed. Since nutritional effects of complex diets emerge only if dietary assessments are validated, nutrimetabolomics offers the validation tools on the basis of food intake biomarkers.
  
  
  CONCLUSIONS
  Apart from the provision, via a high-throughput approach, of objective measurable parameters to be used as biomarkers, a consensus must be reached on the definition of health and wellness. Health (and wellness) can be considered a position having specific coordinates in a multiple-dimension space, and many factors contribute to our movements in this space. Foodomics is the science aiming at studying, through the evaluation of different biomarkers, the entity and the direction of the movements across the healthy or unhealthy space, developing models that are able to explain how food components, food, diet and lifestyle can influence our trajectory toward the healthy condition. Only considering the 'health space' as a multidimensional one, we have the possibility of understanding the complex relationship linking nutrition and health, and of reaching healthier conditions by personalized balanced diets in a foodomics vision.
authors.affiliation: Department of Agro-Food Sciences and Technologies, University of Bologna, Bologna, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Bordoni
authors.forename: Francesco
authors.initials: F
authors.lastname: Capozzi
mesh_terms: D015415:Biomarkers; D004032:Diet; D044127:Epigenesis, Genetic; D057890:Epigenomics; D006262:Health; D006801:Humans; D008019:Life Style; D054647:Nutrigenomics; D009751:Nutritional Requirements; D009752:Nutritional Status
chemical_list: D015415:Biomarkers