title: Association of arterial stiffness and osteoporosis in healthy men undergoing screening medical examination.
abstract: BACKGROUND
  Association of arterial stiffness and osteoporosis has been previously reported in women. However, this association is still controversial for men. Therefore, we investigated correlation of arterial stiffness and osteoporosis by measuring brachial-ankle (ba) pulse wave velocity (PWV) and bone mineral density (BMD).
  
  
  METHODS
  We reviewed medical charts of 239 people (women: 128, men: 111) who visited the Health Promotion Center, retrospectively. ba-PWV was measured by automatic wave analyzer. Lumbar spine (L1-L4) BMD and femur BMD were measured by dual energy X-ray absorptiometry. Metabolic syndrome was based on the National Cholesterol Education Program (NCEP)-Adult Treatment Panel (ATPIII) definition. Body mass index (BMI)>25 kg/m(2) was used instead of waist circumference.
  
  
  RESULTS
  In Pearson's correlation analysis, PWV and femur BMD (Neck, total) had a significant inverse relationship in men (r=-0.254, P=0.007; r=-0.202, P=0.034). In women, PWV and the L-spine, femur (Neck, total) had a significant inverse relationship. (r=-0.321, P<0.001; r=-0.189, P=0.032; r=-0.177, P=0.046) Age and PWV showed the greatest association in both men and women (r=0.46 P<0.001; r=0.525, P<0.001) In multiple regression analysis, the L-spine BMD and PWV had an independent relationship in women after adjusting for age, metabolic syndrome, BMI, smoking, drinking and exercise. (r=-0.229, P=0.015). No independent association was found between PWV and BMD in men.
  
  
  CONCLUSIONS
  The association between arterial stiffness and BMD was confirmed in women. However, this association was not statistically significant for men.
authors.affiliation: Department of Family Medicine, Gachon University Gil Hospital, Incheon, Korea.
authors.forename: Nam Lee
authors.initials: NL
authors.lastname: Kim
authors.affiliation: Department of Family Medicine, Gachon University Gil Hospital, Incheon, Korea.
authors.forename: Ha Min
authors.initials: HM
authors.lastname: Jang
authors.affiliation: Department of Family Medicine, Gachon University Gil Hospital, Incheon, Korea.
authors.forename: Sul Ki
authors.initials: SK
authors.lastname: Kim
authors.affiliation: Department of Family Medicine, Gachon University Gil Hospital, Incheon, Korea.
authors.forename: Ki Dong
authors.initials: KD
authors.lastname: Ko
authors.affiliation: Department of Family Medicine, Gachon University Gil Hospital, Incheon, Korea.
authors.forename: In Cheol
authors.initials: IC
authors.lastname: Hwang
authors.affiliation: Department of Family Medicine, Gachon University Gil Hospital, Incheon, Korea.
authors.forename: Heuy Sun
authors.initials: HS
authors.lastname: Suh
keywords: Bone density; Osteoporosis; Pulse wave analysis; Vascular stiffness