title: Current and future therapies for invasive aspergillosis.
abstract: Invasive fungal infections have increase worldwide and represent a threat for immunocompromised patients including HIV-infected, recipients of solid organ and stem cell transplants, and patients receiving immunosuppressive therapies. High mortality rates and difficulties in early diagnosis characterize pulmonary fungal infections. Invasive pulmonary aspergillosis has been reviewed focussing on therapeutic management. Although new compounds have become available in the past years (i.e., amphotericin B lipid formulations, last-generation azoles, and echinocandines), new diagnostic tools and careful therapeutic management are mandatory to assure an early appropriate targeted treatment that represents the key factor for a successful conservative approach in respiratory fungal infections.
authors.affiliation: Infectious Diseases Division, Santa Maria Misericordia Hospital, Udine, Italy. Electronic address: mattba@tin.it.
authors.forename: Matteo
authors.initials: M
authors.lastname: Bassetti
authors.affiliation: Infectious Diseases Division, Santa Maria Misericordia Hospital, Udine, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Pecori
authors.affiliation: Infectious Diseases Division, Santa Maria Misericordia Hospital, Udine, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Della Siega
authors.affiliation: Department of Medical Sciences, Infectious Diseases Clinic, University of Turin, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Corcione
authors.affiliation: Department of Medical Sciences, Infectious Diseases Clinic, University of Turin, Italy.
authors.forename: Francesco Giuseppe
authors.initials: FG
authors.lastname: De Rosa
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D015195:Drug Design; D006801:Humans; D016867:Immunocompromised Host; D055744:Invasive Pulmonary Aspergillosis / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D058990:Molecular Targeted Therapy
chemical_list: D000935:Antifungal Agents
keywords: Amphotericin; Aspergillus; Echinocandins; Galactomannan; Posaconazole; Voriconazole