title: Synthesis of 4-alkynylquinazolines: Pd-Cu-cocatalyzed coupling of quinazoline-4-tosylates with terminal alkynes using N-heterocyclic carbenes as ligands.
abstract: A Pd-Cu-cocatalyzed coupling reaction of quinazoline-4-tosylates with terminal alkynes using N-heterocyclic carbenes (NHC) as ligands is described, providing 4-alkynylquinazolines in good to excellent yields. This transformation proceeds under mild conditions with high efficiency, which is attractive for focused compound library construction.
authors.affiliation: Key Laboratory of Small Functional Organic Molecule, Ministry of Education, Jiangxi's Key Laboratory of Green Chemistry and College of Life Science, Jiangxi Normal University, Nanchang, Jiangxi 330022, China. yypeng@jxnu.edu.cn yiyuanpeng@yahoo.com.
authors.forename: Yiyuan
authors.initials: Y
authors.lastname: Peng
authors.forename: Ping
authors.initials: P
authors.lastname: Huang
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.forename: Yirong
authors.initials: Y
authors.lastname: Zhou
authors.forename: Jianjun
authors.initials: J
authors.lastname: Yuan
authors.forename: Qin
authors.initials: Q
authors.lastname: Yang
authors.forename: Xin
authors.initials: X
authors.lastname: Jiang
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Deng
authors.forename: Jingshi
authors.initials: J
authors.lastname: Xu