title: Regiocontrolled gold-catalyzed [2+2+2] cycloadditions of ynamides with two discrete nitriles to construct 4-aminopyrimidine cores.
abstract: Reported herein is the novel gold-catalyzed intermolecular [2+2+2] cycloaddition of ynamides with two discrete nitriles to form monomeric 4-aminopyrimidines, which are pharmaceutically important structural motifs. The utility of this new cycloaddition is demonstrated by the excellent regioselectivity obtained using a variety of ynamides and nitriles.
authors.affiliation: Department of Chemistry, National Tsing Hua University, 101, Sec. 2, Kuang-Fu Rd., Hsinchu, 30013 (Taiwan) http://chem-en.web.nthu.edu.tw/files/13-1117-33454.php.
authors.forename: Somnath Narayan
authors.initials: SN
authors.lastname: Karad
authors.forename: Rai-Shung
authors.initials: RS
authors.lastname: Liu
keywords: cycloadditions; gold; heterocycles; homogeneous catalysis; synthetic methods