title: The relationship between hepatic lipase gene variant and advanced age-related macular degeneration: a meta-analysis.
abstract: OBJECTIVE
  To date, no consistency exists across studies that have evaluated the relationship between hepatic lipase gene (LIPC) rs10468017 variant and advanced age-related macular degeneration (AMD).
  
  
  OBJECTIVE
  To summarize all relevant evidence for a relationship between LIPC variant and advanced AMD.
  
  
  METHODS
  The PubMed and Embase databases were searched for studies potentially eligible in any language published up to September 15, 2013.
  
  
  METHODS
  Case-control studies of 2 or more comparison groups that included patients with advanced AMD (choroidal neovascularization or geographic atrophy).
  
  
  METHODS
  Allele frequencies and genotype distributions of rs10468017 variant.
  
  
  METHODS
  Summary odds ratios (ORs) and 95% CIs were estimated under different genetic models using meta-analytic methods. A stratified analysis by advanced AMD subtypes and race/ethnicity was performed, as well as a sensitivity analysis.
  
  
  RESULTS
  Data from 10 case-control studies were included in the meta-analysis. The rs10468017 variant (C→T) showed significant summary ORs of 0.81 (95% CI, 0.75-0.88), 0.83 (95% CI, 0.70-0.98), and 0.60 (95% CI, 0.44-0.81) under the allelic (T vs C), heterozygous (TC vs CC), and homozygous (TT vs CC) models, respectively. Carrying at least 1 copy of the T allele decreased the risk of choroidal neovascularization and geographic atrophy by 20% (OR, 0.80; 95% CI, 0.74-0.87) and 29% (OR, 0.71; 95% CI, 0.59-0.86), respectively. The pooled OR for white race/ethnicity under an allelic model was 0.80 (95% CI, 0.74-0.87). The sensitivity analysis indicated the robustness of our findings, and no evidence of publication bias was observed in our meta-analysis.
  
  
  CONCLUSIONS
  Our meta-analysis indicates that LIPC rs10468017 variant is associated with a reduced risk of advanced AMD. This finding may lead to insights regarding the pathogenesis, prevention, and treatment of AMD.
authors.affiliation: Department of Ophthalmology, Second Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, Zhejiang, China.
authors.forename: Li-Xia
authors.initials: LX
authors.lastname: Lou
authors.affiliation: Department of Oncology, Second Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, Zhejiang, China.
authors.forename: Kai-Min
authors.initials: KM
authors.lastname: Hu
authors.affiliation: Department of Ophthalmology, Second Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, Zhejiang, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Jin
authors.affiliation: Department of Oncology, Second Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, Zhejiang, China.
authors.forename: Su-Zhan
authors.initials: SZ
authors.lastname: Zhang
authors.affiliation: Department of Ophthalmology, Second Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, Zhejiang, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Ye
mesh_terms: D016022:Case-Control Studies; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008049:Lipase / Q000235:genetics*; D008099:Liver / Q000201:enzymology*; D008268:Macular Degeneration / Q000235:genetics*
chemical_list: C504173:LIPC protein, human; D008049:Lipase