title: Oxidative balance score and oxidative stress biomarkers in a study of Whites, African Americans, and African immigrants.
abstract: BACKGROUND
  Oxidative balance score (OBS) is a composite measure of multiple pro- and antioxidant exposures.
  
  
  OBJECTIVE
  To investigate associations of OBS with F2-isoprostanes (FIP), mitochondrial DNA copy number (mtDNA), and fluorescent oxidative products (FOP), and assess inter-relationships among the biomarkers.
  
  
  METHODS
  In a cross-sectional study, associations of a thirteen-component OBS with biomarker levels were assessed using multivariable regression models.
  
  
  RESULTS
  Association of OBS with FIP, but not with FOP, was in the hypothesized direction. The results for mtDNA were unstable and analysis-dependent. The three biomarkers were not inter-correlated.
  
  
  CONCLUSIONS
  Different biomarkers of oxidative stress may reflect different biological processes.
authors.affiliation: Department of Nutrition, Emory University , Atlanta, GA , USA .
authors.forename: Sindhu
authors.initials: S
authors.lastname: Lakkur
authors.forename: Roberd M
authors.initials: RM
authors.lastname: Bostick
authors.forename: Douglas
authors.initials: D
authors.lastname: Roblin
authors.forename: Murugi
authors.initials: M
authors.lastname: Ndirangu
authors.forename: Ike
authors.initials: I
authors.lastname: Okosun
authors.forename: Francis
authors.initials: F
authors.lastname: Annor
authors.forename: Suzanne
authors.initials: S
authors.lastname: Judd
authors.forename: W
authors.initials: W
authors.lastname: Dana Flanders
authors.forename: Victoria L
authors.initials: VL
authors.lastname: Stevens
authors.forename: Michael
authors.initials: M
authors.lastname: Goodman
mesh_terms: D000328:Adult; D000354:Africa, Western / Q000208:ethnology; D001741:Black or African American; D015415:Biomarkers / Q000097:blood; D002338:Carotenoids / Q000097:blood; D003430:Cross-Sectional Studies; D065366:Cryptoxanthins / Q000097:blood; D004272:DNA, Mitochondrial / Q000235:genetics; D004032:Diet; D018628:Gene Dosage; D006801:Humans; D028421:Isoprostanes / Q000097:blood; D000077276:Lycopene; D008875:Middle Aged; D018384:Oxidative Stress; D012680:Sensitivity and Specificity; D044465:White People; D065146:Zeaxanthins / Q000097:blood; D019207:beta Carotene / Q000097:blood
chemical_list: D015415:Biomarkers; D065366:Cryptoxanthins; D004272:DNA, Mitochondrial; D028421:Isoprostanes; D065146:Zeaxanthins; D019207:beta Carotene; D002338:Carotenoids; C041635:alpha-carotene; D000077276:Lycopene
keywords: Oxidative balance; oxidative stress; race