title: A case of toxic epidermal necrolysis caused by trimethoprim-sulfamethoxazole.
abstract: Toxic epidermal necrolysis (TEN) is a rare but serious dermatological emergency characterised by diffuse exfoliation of the skin and mucous membranes due to immune mediated destruction of the epidermis which can lead to sepsis and respiratory distress. Trimethoprim-sulfamethoxazole is a widely used antibiotic which can rarely lead to TEN. Early diagnosis and aggressive medical care is essential for the reduction of high morbidity and mortality associated with this disease. We present a case of successfully recovered TEN due to trimethoprim-sulfamethoxazole in a 62-year-old woman.
authors.affiliation: Miriam Hospital, Providence, Rhode Island, USA.
authors.forename: Jharendra P
authors.initials: JP
authors.lastname: Rijal
authors.affiliation: Staten Island University Hospital, Staten Island, New York, USA.
authors.forename: Tiffany
authors.initials: T
authors.lastname: Pompa
authors.affiliation: University of Tennessee Health Science Center, Memphis, Tennessee, USA.
authors.forename: Smith
authors.initials: S
authors.lastname: Giri
authors.affiliation: University of Nebraska Medical Center, Omaha, Nebraska, USA.
authors.forename: Vijaya Raj
authors.initials: VR
authors.lastname: Bhatt
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D019072:Antibiotic Prophylaxis / Q000379:methods; D004305:Dose-Response Relationship, Drug; D042241:Early Diagnosis; D005260:Female; D005440:Fluid Therapy; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D013262:Stevens-Johnson Syndrome / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D016896:Treatment Outcome; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage / Q000009:adverse effects*; D014552:Urinary Tract Infections / Q000188:drug therapy*; D014945:Wound Healing
chemical_list: D000900:Anti-Bacterial Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination