title: Polycondensation of polymer brushes via DNA hybridization.
abstract: Triblock copolymer brushes were functionalized with nucleic acid sequences, which allowed the polymers to connect head-to-tail and form supramolecular nanostructures. Two approaches were designed and implemented, using either a palindromic DNA attached to both ends of the polymer or two different DNA sequences attached regiospecifically. Given appropriate conditions, the DNA-brush conjugates self-assembled to form either nanoworms with length up to several microns or cross-linked networks. This process is analogous to the step-growth polymerization of small molecule monomers.
authors.affiliation: Department of Chemistry and Chemical Biology, Northeastern University , Boston, Massachusetts 02115, United States.
authors.forename: Xueguang
authors.initials: X
authors.lastname: Lu
authors.forename: Eleanor
authors.initials: E
authors.lastname: Watts
authors.forename: Fei
authors.initials: F
authors.lastname: Jia
authors.forename: Xuyu
authors.initials: X
authors.lastname: Tan
authors.forename: Ke
authors.initials: K
authors.lastname: Zhang
mesh_terms: D004247:DNA / Q000737:chemistry*; D055029:Inverted Repeat Sequences; D008301:Maleimides / Q000737:chemistry; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures / Q000737:chemistry*; D009636:Norbornanes / Q000737:chemistry; D009693:Nucleic Acid Hybridization; D011092:Polyethylene Glycols / Q000737:chemistry; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry*; D013388:Succinimides / Q000737:chemistry; D013499:Surface Properties
chemical_list: D008301:Maleimides; D009636:Norbornanes; D011108:Polymers; D013388:Succinimides; D011092:Polyethylene Glycols; D004247:DNA; C001426:N-hydroxysuccinimide