title: The emerging landscape of salivary diagnostics.
abstract: Saliva as a diagnostic tool provides a noninvasive, simple and low-cost method for disease detection and screening. Saliva collection is more practical and comfortable compared with other invasive methods, and saliva can be a desirable body fluid for biomarker detection in clinical applications. The integration of omics methods has allowed accurate detection and quantification of transcripts found in saliva and a group of biomarkers has been discovered and validated in a series of studies. Here we review recent developments in salivary diagnostics that have been accomplished using salivaomics, the mechanisms of saliva diagnostics, as well as the translational and clinical application of saliva biomarkers.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jie
authors.initials: J
authors.lastname: Sun
authors.forename: Chien-Chung
authors.initials: CC
authors.lastname: Lin
authors.forename: Elliot
authors.initials: E
authors.lastname: Abemayor
authors.forename: Marilene B
authors.initials: MB
authors.lastname: Wang
authors.affiliation: University of California at Los Angeles School of Dentistry, 73-017 CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA, Tel: 310-206-3048; Fax: 310-825-7609; e-mail: dtww@ucla.edu.
authors.forename: David T W
authors.initials: DT
authors.lastname: Wong