title: Highly enantioselective aza-Henry reaction with isatin N-Boc ketimines.
abstract: A highly enantioselective aza-Henry reaction with isatin N-Boc ketimines using a Cu(II)-BOX complex as a catalyst is described. The reaction, which does not require protection of the N1 atom, provides the corresponding nitroamines bearing a quaternary stereocentre with high yields and enantiomeric excesses (up to 99.9%).
authors.affiliation: Departament de Química Orgànica, Facultat de Química, Universitat de València, C/ Dr. Moliner 50, E-46100 Burjassot (València), Spain. jose.r.pedro@uv.es gonzalo.blay@uv.es.
authors.forename: Melireth
authors.initials: M
authors.lastname: Holmquist
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Blay
authors.forename: José R
authors.initials: JR
authors.lastname: Pedro