title: [Study and evaluation of preparation of silybin PLGA microspheres by stainless steel membrane emulsification technique].
abstract: OBJECTIVE
  The aim of the present study was to prepare uniform-sized silybin loaded poly (lactic-co-glycolic acid) (PLGA) microspheres in study of silybin with stainless steel membrane.
  
  
  METHODS
  Silybin PLGA microspheres were prepared by stainless steel membrane emulsification. The preparation conditions were optimized by single-factor test and orthogonal experiment, and evaluating the mean diameters, the particle size distribution, drug loading, entrapment efficiency and morphology of microsphere.
  
  
  RESULTS
  Prepared microspheres were round and surface was smooth. The mean diameter was (4.961 +/- 0.56) microm. The span was (1.75 +/- 0.18). The entrapment efficiency was (54.997 +/- 4.05)% and the average drug loading was (23.6 +/- 1.70)%.
  
  
  CONCLUSIONS
  The stainless steel membrane emulsification can be used to prepare the silybin PLGA microspheres. The mean diameters of the silybin PLGA microspheres can be controlled in certain level. Stainless steel membrane emulsification has great potentiality exploitation and utilization.
authors.forename: Kun
authors.initials: K
authors.lastname: Rong
authors.forename: Bin-Li
authors.initials: BL
authors.lastname: Liu
authors.forename: Mu-Zi
authors.initials: MZ
authors.lastname: Li
authors.forename: Liang-Liang
authors.initials: LL
authors.lastname: Xu
authors.forename: Xin
authors.initials: X
authors.lastname: Yi
authors.forename: Cheng-Ke
authors.initials: CK
authors.lastname: Cai
mesh_terms: D004339:Drug Compounding / Q000379:methods*; D004655:Emulsions / Q000737:chemistry; D019344:Lactic Acid / Q000737:chemistry*; D008863:Microspheres; D010316:Particle Size; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D000077385:Silybin; D012838:Silymarin / Q000737:chemistry*; D013193:Stainless Steel / Q000737:chemistry
chemical_list: D004655:Emulsions; D012838:Silymarin; D013193:Stainless Steel; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D000077385:Silybin