title: Sorcin antibody as a possible predictive factor in conversion from radiologically isolated syndrome to multiple sclerosis: a preliminary study.
abstract: OBJECTIVE
  To identify an antibody biomarker for prediction of conversion from radiologically isolated syndrome (RIS) to relapsing remitting multiple sclerosis (RRMS).
  
  
  METHODS
  Sera of 13 RIS patients were screened by a protein macroarray derived from human fetal brain cDNA library.
  
  
  RESULTS
  Sequencing of a clone with the highest signal intensity revealed sorcin as a potential target autoantigen in RIS patients. ELISA studies showed high-titer sorcin-antibodies in 3 of 4 RIS patients who converted to RRMS in a 5-year follow-up period and 13 of 23 control RRMS patients.
  
  
  CONCLUSIONS
  The value of sorcin antibody as a predictor of conversion from RIS to RRMS requires to be tested in larger prospective studies.
authors.affiliation: Department of Genetics, Institute for Experimental Medicine (DETAE), Istanbul University, Istanbul, Turkey.
authors.forename: Elçin
authors.initials: E
authors.lastname: Sehitoğlu
authors.forename: Filiz
authors.initials: F
authors.lastname: Cavuş
authors.forename: Canan
authors.initials: C
authors.lastname: Ulusoy
authors.forename: Melike
authors.initials: M
authors.lastname: Küçükerden
authors.forename: Arda
authors.initials: A
authors.lastname: Orçen
authors.forename: Deniz
authors.initials: D
authors.lastname: Akbaş-Demir
authors.forename: Arzu
authors.initials: A
authors.lastname: Coban
authors.forename: Burçak
authors.initials: B
authors.lastname: Vural
authors.forename: Erdem
authors.initials: E
authors.lastname: Tüzün
authors.forename: Recai
authors.initials: R
authors.lastname: Türkoğlu
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002135:Calcium-Binding Proteins / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000097:blood* / Q000276:immunology; D013577:Syndrome
chemical_list: D015415:Biomarkers; D002135:Calcium-Binding Proteins; D007074:Immunoglobulin G; C503113:SRI protein, human