title: Homocysteine Levels and Oxidative Stress Parameters in Patients With Adult ADHD.
abstract: OBJECTIVE
  In our study, we aimed to evaluate the plasma homocysteine levels and oxidative stress parameters in patients with adult ADHD (A-ADHD).
  
  
  METHODS
  Blood samples were taken from 32 A-ADHD patients and 32 controls enrolled in the study and plasma homocysteine, serum folate, vitamin B12, total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were determined. Results were compared between the groups.
  
  
  RESULTS
  Patients' plasma homocysteine level was significantly lower and serum folate level was significantly higher than the controls. The means of plasma homocysteine and folate levels were statistically significantly different between the groups ( p < .05). However, a statistically significant difference was not detected between groups for mean serum vitamin B12, TAS, TOS, and OSI levels ( p > .05).
  
  
  CONCLUSIONS
  Our study suggests that oxidative balance is not impaired in A-ADHD, and contrary to other psychiatric disorders, homocysteine levels were found to be lower.
authors.affiliation: 1 Harran University, Sanliurfa, Turkey.
authors.forename: İbrahim Fatih
authors.initials: İF
authors.lastname: Karababa
authors.affiliation: 2 Antalya Training and Research Hospital, Turkey.
authors.forename: Sermin Nur
authors.initials: SN
authors.lastname: Savas
authors.affiliation: 3 Bezmialem Vakif University, İstanbul, Turkey.
authors.forename: Sehabettin
authors.initials: S
authors.lastname: Selek
authors.affiliation: 4 Mevlana University, Konya, Turkey.
authors.forename: Erdinc
authors.initials: E
authors.lastname: Cicek
authors.affiliation: 5 Konya Training and Research Hospital, Turkey.
authors.forename: Esra Ismet
authors.initials: EI
authors.lastname: Cicek
authors.affiliation: 1 Harran University, Sanliurfa, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Asoglu
authors.affiliation: 1 Harran University, Sanliurfa, Turkey.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Bayazit
authors.affiliation: 1 Harran University, Sanliurfa, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Kandemir
authors.affiliation: 1 Harran University, Sanliurfa, Turkey.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Kati
authors.affiliation: 1 Harran University, Sanliurfa, Turkey.
authors.forename: Turgay
authors.initials: T
authors.lastname: Ulas
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D001289:Attention Deficit Disorder with Hyperactivity / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D005492:Folic Acid / Q000378:metabolism; D006710:Homocysteine / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016877:Oxidants / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*; D014805:Vitamin B 12 / Q000378:metabolism
chemical_list: D000975:Antioxidants; D016877:Oxidants; D006710:Homocysteine; D005492:Folic Acid; D014805:Vitamin B 12
keywords: adult ADHD; homocysteine; oxidative status