title: Brain endothelial cell targeting via a peptide-functionalized liposomal carrier for xenon hyper-CEST MRI.
abstract: A nanoparticulate carrier system is used to efficiently deliver a contrast agent for highly sensitive xenon Hyper-CEST MRI. The carrier system not only improves the biocompatibility and solubility of the contrast agent, it also allows selective cell targeting as demonstrated by the discrimination of human brain capillary and aortic endothelial cells.
authors.affiliation: ERC Project BiosensorImaging, Leibniz-Institut für Molekulare Pharmakologie, Robert-Rössle-Str. 10, 13125, Berlin, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Schnurr
authors.forename: Karl
authors.initials: K
authors.lastname: Sydow
authors.forename: Honor May
authors.initials: HM
authors.lastname: Rose
authors.forename: Margitta
authors.initials: M
authors.lastname: Dathe
authors.forename: Leif
authors.initials: L
authors.lastname: Schröder
mesh_terms: D001812:Blood-Brain Barrier / Q000000981:diagnostic imaging* / Q000378:metabolism*; D002478:Cells, Cultured; D042783:Endothelial Cells / Q000000981:diagnostic imaging* / Q000378:metabolism*; D006801:Humans; D008081:Liposomes; D018810:Magnetic Resonance Angiography; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*; D011859:Radiography
chemical_list: D008081:Liposomes; D010455:Peptides
keywords: MRI; blood-brain barrier; liposomes; nanocarriers; xenon Hyper-CEST