title: Anti-cancer drug discovery: update and comparisons in yeast, Drosophila, and zebrafish.
abstract: Discovery of novel cancer chemotherapeutics focuses on screening and identifying compounds that can target 'cancer-specific' biological processes while causing minimal toxicity to non-tumor cells. Alternatively, model organisms with highly conserved cancer-related cellular processes relative to human cells may offer new opportunities for anticancer drug discovery when combined with chemical screening. Some organisms used for chemotherapeutic discovery include yeast, Drosophila, and zebrafish which are similar in important ways relevant to cancer study but offer distinct advantages as well. Here, we describe these model attributes and the rationale for using them in cancer drug screening research.
authors.forename: Guangxun
authors.initials: G
authors.lastname: Gao
authors.forename: Liang
authors.initials: L
authors.lastname: Chen
authors.affiliation: Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA. chuanshu.huang@nyumc.org.
authors.forename: Chuanshu
authors.initials: C
authors.lastname: Huang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D004330:Drosophila / Q000378:metabolism; D055808:Drug Discovery; D057166:High-Throughput Screening Assays; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D015027:Zebrafish / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents