title: Epidemiologic investigation of polycystic ovarian syndrome (PCOS) in Han ethnic women of reproductive age in Liaoning Province, China.
abstract: OBJECTIVE
  To determine the incidence of polycystic ovary syndrome (PCOS) among Han women of reproductive age in Liaoning Province in Northeastern China, based on the Revised Rotterdam 2003 criteria.
  
  
  METHODS
  A retrospective cohort study was carried out on 1,600 women using questionnaires, physical examination, ultrasonography, and biochemical indices (aged = 19 to 45 years; n = 1,600). PCOS patients were identified using the Revised Rotterdam 2003 criteria.
  
  
  RESULTS
  A total of 132 Han women of reproductive age were diagnosed with PCOS, with a prevalence of 8.25%. The prevalence of menstrual dysfunction was as follows: 97 patients (73.48%) had abnormal menstruation, three (2.27%) had polymenorrhea, and 94 (71.21%) had oligomenorrhea. Up to 64 patients (48.48%) had androgen excess, 42 (31.82%) had biochemical evidence of androgen excess, and 34 (25.76%) had clinical androgen excess. Up to 34 patients (25.76%) were obese (body mass index [BMI] > or = 25) and 19 (14.39%) had hirsutism (F-G scoring > or = 6). A total of 127 patients (96.22%) were diagnosed with PCOS via ultrasonography, 67 of whom (50.76%) had a unilateral polycystic ovary and 60 (45.46%) had bilateral polycystic ovaries.
  
  
  CONCLUSIONS
  The prevalence of PCOS in this study population was 8.25%, with an infertility rate of 27.8%. The classical manifestation of PCOS is PCO, abnormal menstruation, and obesity. The high-risk factors of PCOS include high free testosterone index, homeostasis model assessment-insulin resistance (HOMA-IR), increased serum testosterone and androstenedione, decreased sex hormone-binding globulin, long history of infertility, menarche later than 16 years old, and failure to have regular menstruation within two years.
authors.forename: J
authors.initials: J
authors.lastname: Jiao
authors.forename: Y
authors.initials: Y
authors.lastname: Fang
authors.forename: T
authors.initials: T
authors.lastname: Wang
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.forename: M
authors.initials: M
authors.lastname: Zhou
authors.forename: X
authors.initials: X
authors.lastname: Wang
mesh_terms: D000328:Adult; D000728:Androgens / Q000097:blood; D002681:China / Q000453:epidemiology; D005260:Female; D006628:Hirsutism / Q000208:ethnology*; D006801:Humans; D015994:Incidence; D007247:Infertility, Female / Q000453:epidemiology; D008297:Male; D008599:Menstruation Disturbances / Q000208:ethnology*; D008875:Middle Aged; D009765:Obesity / Q000208:ethnology*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000000981:diagnostic imaging / Q000208:ethnology*; D015995:Prevalence; D012189:Retrospective Studies; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D000728:Androgens