title: Baseline HBsAg predicts response to pegylated interferon-α2b in HBeAg-positive chronic hepatitis B patients.
abstract: OBJECTIVE
  To evaluate the predictive effect of baseline hepatitis B surface antigen (HBsAg) on response to pegylated interferon (PEG-IFN)-α2b in hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) patients.
  
  
  METHODS
  This retrospective analysis compared the treatment efficacy of PEG-IFN-α2b alone in 55 HBeAg-positive CHB patients with different baseline HBsAg levels. Serum HBV DNA load was measured at baseline, and at 12, 24 and 48 wk of therapy. Virological response was defined as HBV DNA < 1000 IU/mL. Serum HBsAg titers were quantitatively assayed at baseline, and at 12 and 24 wk.
  
  
  RESULTS
  Eighteen patients had baseline HBsAg > 20 000 IU/mL, 26 patients had 1500-20000 IU/mL, and 11 patients had < 1500 IU/mL. Three (16.7%), 11 (42.3%) and seven (63.6%) patients in each group achieved a virological response at week 48, with a significant difference between groups with baseline HBsAg levels > 20000 or < 20000 IU/mL (P = 0.02). Thirteen patients had an HBsAg decline > 0.5 log10 and 30 patients < 0.5 log10 at week 12; and 6 (46.2%) and 10 (33.3%) in each group achieved virological response at week 48, with no significant difference between the two groups (P = 0.502). Eighteen patients had an HBsAg decline > 1.0 log10 and 30 patients < 1.0 log10 at week 24, and 8 (44.4%) and 11 (36.7%) achieved a virological response at week 48, with no significant difference between the two groups (P = 0.762). None of the 16 patients with HBsAg > 20000 IU/mL at week 24 achieved a virological response at week 48.
  
  
  CONCLUSIONS
  Baseline HBsAg level in combination with HBV DNA may become an effective predictor for guiding optimal therapy with PEG-IFN-α2b against HBeAg-positive CHB.
authors.affiliation: Gong-Ying Chen, Meng-Fei Zhu, Jie Wang, Guo-Qiang Lou, Hospital Affiliated to Hangzhou Normal University, Hangzhou 310015, Zhejiang Province, China.
authors.forename: Gong-Ying
authors.initials: GY
authors.lastname: Chen
authors.affiliation: Gong-Ying Chen, Meng-Fei Zhu, Jie Wang, Guo-Qiang Lou, Hospital Affiliated to Hangzhou Normal University, Hangzhou 310015, Zhejiang Province, China.
authors.forename: Meng-Fei
authors.initials: MF
authors.lastname: Zhu
authors.affiliation: Gong-Ying Chen, Meng-Fei Zhu, Jie Wang, Guo-Qiang Lou, Hospital Affiliated to Hangzhou Normal University, Hangzhou 310015, Zhejiang Province, China.
authors.forename: Da-Liang
authors.initials: DL
authors.lastname: Zheng
authors.affiliation: Gong-Ying Chen, Meng-Fei Zhu, Jie Wang, Guo-Qiang Lou, Hospital Affiliated to Hangzhou Normal University, Hangzhou 310015, Zhejiang Province, China.
authors.forename: Yan-Ting
authors.initials: YT
authors.lastname: Bao
authors.affiliation: Gong-Ying Chen, Meng-Fei Zhu, Jie Wang, Guo-Qiang Lou, Hospital Affiliated to Hangzhou Normal University, Hangzhou 310015, Zhejiang Province, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.affiliation: Gong-Ying Chen, Meng-Fei Zhu, Jie Wang, Guo-Qiang Lou, Hospital Affiliated to Hangzhou Normal University, Hangzhou 310015, Zhejiang Province, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Gong-Ying Chen, Meng-Fei Zhu, Jie Wang, Guo-Qiang Lou, Hospital Affiliated to Hangzhou Normal University, Hangzhou 310015, Zhejiang Province, China.
authors.forename: Guo-Qiang
authors.initials: GQ
authors.lastname: Lou
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D004279:DNA, Viral / Q000097:blood; D005260:Female; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006515:Hepatitis B virus / Q000187:drug effects* / Q000235:genetics / Q000276:immunology; D019694:Hepatitis B, Chronic / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols / Q000627:therapeutic use*; D011237:Predictive Value of Tests; D011994:Recombinant Proteins / Q000627:therapeutic use; D012074:Remission Induction; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D000998:Antiviral Agents; D015415:Biomarkers; D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; C417083:peginterferon alfa-2b
keywords: Baseline; Chronic hepatitis B; Hepatitis B surface antigen; Pegylated interferon-α2b; Virological response