title: Synthesis of a 2"-deoxy-β-GalCer.
abstract: Structural studies of ternary complexes of CD1d/glycosyl ceramides/iNKT cells and CD1d/sulfatide/sulfatide reactive Type II NKT cells have shown how the polar moieties on the glycolipids interact with both the antigen presenting protein (CD1d) and the T cell receptors. However, these structures alone do not reveal the relative importance of these interactions. This study focuses on the synthesis of the previously unknown 2"-deoxy-β-galactosyl ceramide 2. This glycolipid is also evaluated for its ability to stimulate iNKT cells and sulfatide-reactive Type II NKT cells.
authors.affiliation: Department of Chemistry, University of Connecticut, 55 N. Eagleville Rd., Storrs, CT 06269, USA.
authors.forename: Meena S
authors.initials: MS
authors.lastname: Thakur
authors.affiliation: La Jolla Institute of Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
authors.forename: Archana
authors.initials: A
authors.lastname: Khurana
authors.affiliation: La Jolla Institute of Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
authors.forename: Mitchell
authors.initials: M
authors.lastname: Kronenberg
authors.affiliation: Department of Chemistry, University of Connecticut, 55 N. Eagleville Rd., Storrs, CT 06269, USA. amy.howell@uconn.edu.
authors.forename: Amy R
authors.initials: AR
authors.lastname: Howell
mesh_terms: D000818:Animals; D055610:Antigens, CD1d / Q000378:metabolism; D005699:Galactosylceramides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007376:Interleukin-2 / Q000096:biosynthesis; D051379:Mice; D055611:Natural Killer T-Cells / Q000187:drug effects / Q000378:metabolism
chemical_list: D055610:Antigens, CD1d; D005699:Galactosylceramides; D007376:Interleukin-2