title: Synthesis of enantiomerically pure Tröger's base derivatives via chiral disulfoxides.
abstract: The preparation, full characterization and determination of the absolute configuration of diastereomerically pure disulfoxide derivatives of Tröger's base are described. A sulfinyl-lithium exchange followed by the reaction with electrophiles affords synthetically meaningful amounts of enantiomerically pure 4,10-disubstituted Tröger's base analogues without any erosion of the stereogenic information at the nitrogen centers.
authors.affiliation: Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, ETH Zurich, 8093 Zurich, Switzerland. cvengros@inorg.chem.ethz.ch.
authors.forename: Pavol
authors.initials: P
authors.lastname: Ondrisek
authors.forename: Rino
authors.initials: R
authors.lastname: Schwenk
authors.forename: Ján
authors.initials: J
authors.lastname: Cvengroš