title: The effect of a new impregnated gauze containing bentonite and halloysite minerals on blood coagulation and wound healing.
abstract: In recent years, a wide variety of research has been carried out in the field of novel technologies to stop severe bleeding. In several studies, coagulation properties of minerals such as zeolite, bentonite and halloysite have been proven. In this study, the effect of a new impregnated sterile gauze containing bentonite and halloysite minerals was studied on blood coagulation and wound healing rate in male Wistar rats. Initially, impregnated sterile gauze was prepared from the mixture of bentonite and halloysite minerals and petroleum jelly (Vaseline). Then, the effect of gauze was studied on the blood coagulation time and wound healing process in 40 Wistar rats. SPSS software was used for data analysis and P values less than 0.05 were considered significant. The coagulation time of 81.10 ± 2.532 s in the control group and 33.00 ± 1.214 s in the study group (bentonite-halloysite treated) were reported (P < 0.0005). Time for complete wound healing in the group, which is treated with impregnated sterile pads, was calculated approximately from 10 to 12 days. However, in the control group, there was no complete wound healing (P < 0.0005). According to the results of the present study, topical application of the bentonite-halloysite impregnated sterile gauze significantly decreases the clotting time and increase the wound healing rate.
authors.affiliation: aIonizing and Non-Ionizing Radiation Protection Research Center, Paramedical Sciences School bDiagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mehrosadat
authors.initials: M
authors.lastname: Alavi
authors.forename: Alireza
authors.initials: A
authors.lastname: Totonchi
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Okhovat
authors.forename: Motahareh
authors.initials: M
authors.lastname: Motazedian
authors.forename: Peyman
authors.initials: P
authors.lastname: Rezaei
authors.forename: Mohammad
authors.initials: M
authors.lastname: Atefi
mesh_terms: D000279:Administration, Cutaneous; D000538:Aluminum Silicates / Q000494:pharmacology*; D000818:Animals; D001458:Bandages; D001546:Bentonite / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D000077215:Clay; D006470:Hemorrhage / Q000097:blood / Q000188:drug therapy*; D008297:Male; D010577:Petrolatum; D051381:Rats; D017208:Rats, Wistar; D014914:Whole Blood Coagulation Time; D014945:Wound Healing / Q000187:drug effects*; D014949:Wounds, Nonpenetrating / Q000097:blood / Q000628:therapy*
chemical_list: D000538:Aluminum Silicates; D001546:Bentonite; D010577:Petrolatum; D000077215:Clay