title: Great heterogeneity of commercial fruit juices to induce endothelium-dependent relaxations in isolated porcine coronary arteries: role of the phenolic content and composition.
abstract: Since polyphenol-rich products such as red wine, grape juice, and grape extracts have been shown to induce potent endothelium-dependent relaxations, we have evaluated whether commercial fruit juices such as those from berries are also able to induce endothelium-dependent relaxations of isolated coronary arteries and, if so, to determine whether this effect is related to their phenolic content. Among the 51 fruit juices tested, 2/12 grape juices, 3/7 blackcurrant juices, 4/5 cranberry juices, 1/6 apple juices, 0/5 orange juices, 2/6 red fruit and berry juices, 3/6 blends of red fruit juices, and 0/4 non-red fruit juices were able to induce relaxations achieving more than 50% at a volume of 1%. The active fruit juices had phenolic contents ranging from 0.31 to 1.86 g GAE/L, which were similar to those of most of the less active juices with the exception of one active grape juice (2.14 g GAE/L) and one active blend of red fruit juices (3.48 g GAE/L). Altogether, these findings indicate that very few commercial fruit juices have the ability to induce potent endothelium-dependent relaxations, and that this effect is not related to their quantitative phenolic content, but rather to their qualitative phenolic composition.
authors.affiliation: UMR CNRS 7213, Laboratory of Biophotonics and Pharmacology, Faculty of Pharmacy, University of Strasbourg , Illkirch, France .
authors.forename: Cyril
authors.initials: C
authors.lastname: Auger
authors.forename: Brigitte
authors.initials: B
authors.lastname: Pollet
authors.forename: Cécile
authors.initials: C
authors.lastname: Arnold
authors.forename: Céline
authors.initials: C
authors.lastname: Marx
authors.forename: Valérie B
authors.initials: VB
authors.lastname: Schini-Kerth
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001628:Beverages; D002957:Citrus / Q000737:chemistry; D003132:Commerce; D003331:Coronary Vessels / Q000187:drug effects*; D004730:Endothelium, Vascular / Q000187:drug effects*; D005638:Fruit / Q000737:chemistry*; D027845:Malus / Q000737:chemistry; D010636:Phenols / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D059808:Polyphenols / Q000494:pharmacology; D031965:Ribes / Q000737:chemistry; D013552:Swine; D029796:Vaccinium / Q000737:chemistry; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology*; D027843:Vitis / Q000737:chemistry
chemical_list: D000975:Antioxidants; D010636:Phenols; D010936:Plant Extracts; D059808:Polyphenols; D014665:Vasodilator Agents
keywords: endothelial function; fruit juice; polyphenols; vasorelaxation