title: The influence of hypoxia during different pregnancy stages on cardiac collagen accumulation in the adult offspring.
abstract: We evaluated whether the timing of maternal hypoxia during pregnancy influenced cardiac extracellular matrix accumulation in the adult offspring. Rats in different periods of pregnancy were assigned to maternal hypoxia or control groups. Maternal hypoxia from day 3 to 21 of pregnancy or day 9 to 21 of pregnancy increased collagen I and collagen III expression in the left ventricle of adult offspring (both P<0.05). Maternal hypoxia from day 15 to 21 of pregnancy had no effect on adult collagen levels. Our results indicate that maternal hypoxia at critical windows of cardiovascular development can induce pathological cardiac remodeling in the adult rat offspring.
authors.affiliation: Department of Neurology, Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian 362000, China.
authors.forename: Lingxing
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian 362000, China.
authors.forename: Meimei
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Cardiology, Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian 362000, China.
authors.forename: Ziyang
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Department of Cardiology, Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian 362000, China.
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000818:Animals; D003094:Collagen / Q000096:biosynthesis*; D005109:Extracellular Matrix / Q000378:metabolism; D005260:Female; D006321:Heart / Q000254:growth & development*; D006352:Heart Ventricles / Q000378:metabolism; D006801:Humans; D000860:Hypoxia / Q000378:metabolism* / Q000473:pathology; D009206:Myocardium / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats
chemical_list: D003094:Collagen