title: [Peculiarities of microbiological and immunological indices of human nose mucosa in conditions of man-made pollution].
abstract: Possible influence of man-made load on formation and function of microbiocenosis of the nose mucosa in practically healthy people of industrial city has been studied. Microbiota composition, content of secretory immunoglobulin A, functional state and expression of TLR-2 and TLR-4 by mucosa cells were studied in the given human biotope. The residing in conventionally contaminated districts of the industrial city tells on the increase of ecologic role of Candida albicans in the composition of microbiocenosis of the nose mucosa. The authors have shown high sensitivity of the number of TLR-4-positive epithelial cells to the type of the basic taxon of a microorganism in the composition of the nose mucosa microbiota and also sensitivity of the number of TLR-2 and TLR-4-positive epithelial cells and the density of expression by TLR-4 epithelial cells to the man-made pollution, they have also established the expressed unbalance of the system of inherent immunity of the nose mucosa of practically healthy young persons in conditions of man-made pollution.
authors.forename: O V
authors.initials: OV
authors.lastname: Voĭtovych
authors.forename: O M
authors.initials: OM
authors.lastname: Kamyshnyĭ
mesh_terms: D000293:Adolescent; D002176:Candida albicans / Q000254:growth & development; D002353:Carrier State / Q000276:immunology / Q000382:microbiology; D004787:Environmental Pollution; D004847:Epithelial Cells / Q000276:immunology* / Q000382:microbiology; D015870:Gene Expression; D006098:Granulocytes / Q000276:immunology* / Q000382:microbiology; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007070:Immunoglobulin A / Q000378:metabolism; D008297:Male; D064307:Microbiota / Q000276:immunology; D009297:Nasal Mucosa / Q000276:immunology* / Q000382:microbiology; D013210:Staphylococcus / Q000254:growth & development; D013291:Streptococcus / Q000254:growth & development; D051195:Toll-Like Receptor 2 / Q000235:genetics / Q000276:immunology; D051197:Toll-Like Receptor 4 / Q000235:genetics / Q000276:immunology; D014455:Ukraine; D014505:Urban Population; D055815:Young Adult
chemical_list: D007070:Immunoglobulin A; C495342:TLR2 protein, human; C495345:TLR4 protein, human; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4