title: Effects of Fructus Akebiae on learning and memory impairment in a scopolamine-induced animal model of dementia.
abstract: Fructus Akebiae (FAE) is a component of traditional Chinese medicines used for the clinical treatment of amnesia. The aim of the present study was to investigate the effects of FAE extract on scopolamine-induced learning and memory impairment in mice and Sprague-Dawley rats. Treatment with FAE (2.5, 5 and 10 mg/kg) was investigated in scopolamine-treated animals, and its effects on different types of memory were examined using the T-maze, the Morris water maze task, the novel object recognition test, the passive avoidance task and the step-down test. The results revealed that 5 and 10 mg/kg FAE attenuated scopolamine-mediated impairment of cognition, including spatial, episodic, aversive, and short- and long-term memory. Overall, these results suggest that FAE is an effective cognitive enhancer, and thus highlights the value of a multi-target strategy to address the complexity of cognitive dysfunction in Alzheimer's disease.
authors.affiliation: Anesthesia and Operation Center, Chinese PLA General Hospital and Medical School of Chinese PLA, Beijing 100853, P.R. China.
authors.forename: Jinghua
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Psychiatry, Beijing Huilongguan Hospital, Beijing 100096, P.R. China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Wang
authors.affiliation: Anesthesia and Operation Center, Chinese PLA General Hospital and Medical School of Chinese PLA, Beijing 100853, P.R. China.
authors.forename: Baosheng
authors.initials: B
authors.lastname: Lv
authors.affiliation: Anesthesia and Operation Center, Chinese PLA General Hospital and Medical School of Chinese PLA, Beijing 100853, P.R. China.
authors.forename: Weixiu
authors.initials: W
authors.lastname: Yuan
authors.affiliation: Anesthesia and Operation Center, Chinese PLA General Hospital and Medical School of Chinese PLA, Beijing 100853, P.R. China.
authors.forename: Zeguo
authors.initials: Z
authors.lastname: Feng
authors.affiliation: Anesthesia and Operation Center, Chinese PLA General Hospital and Medical School of Chinese PLA, Beijing 100853, P.R. China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Mi
authors.affiliation: Anesthesia and Operation Center, Chinese PLA General Hospital and Medical School of Chinese PLA, Beijing 100853, P.R. China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
keywords: Fructus Akebiae; cognition; learning and memory impairment; scopolamine-induced