title: TORC2-a new player in genome stability.
abstract: The inhibition of the central growth regulatory kinase TOR, which participates in two complexes, TORC1 and TORC2, has been a focus of metabolic and cancer studies for many years. Most studies have dealt with TORC1, the canonical target of rapamycin, and the role of this complex in autophagy, protein synthesis, and cell growth control. Recent work on TORC2 in budding and fission yeast species points to a conserved role of this lesser-known TOR complex in the survival of DNA damage. In budding yeast, TORC2 controls lipid biosynthesis and actin cytoskeleton through downstream AGC kinases, which are now, surprisingly, implicated in the survival of oxidative DNA damage. Preliminary data from mTORC2 modulation in cancer cells suggest that an extension to human chemotherapy is worth exploring.
authors.affiliation: Department of Natural and Life Sciences, The Open University of Israel, Raanana, Israel ronitwe@openu.ac.il susan.gasser@fmi.ch.
authors.forename: Ronit
authors.initials: R
authors.lastname: Weisman
authors.affiliation: Department of Natural and Life Sciences, The Open University of Israel, Raanana, Israel.
authors.forename: Adiel
authors.initials: A
authors.lastname: Cohen
authors.affiliation: Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland ronitwe@openu.ac.il susan.gasser@fmi.ch.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Gasser
mesh_terms: D000199:Actins / Q000378:metabolism; D004249:DNA Damage; D042822:Genomic Instability; D050356:Lipid Metabolism; D000076225:Mechanistic Target of Rapamycin Complex 2; D046912:Multiprotein Complexes / Q000378:metabolism*; D018384:Oxidative Stress; D004718:Saccharomycetales / Q000502:physiology*; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*
chemical_list: D000199:Actins; D046912:Multiprotein Complexes; D000076225:Mechanistic Target of Rapamycin Complex 2; D058570:TOR Serine-Threonine Kinases
keywords: DNA damage; TORC1; TORC2; cancer therapies; mTOR