title: Functional connectivity and grey matter volume of the striatum in schizophrenia.
abstract: BACKGROUND
  Alterations in the dopaminergic reward system, predominantly the striatum, constitute core characteristics of schizophrenia.
  
  
  OBJECTIVE
  Functional connectivity of the dorsal striatum during reward-related trial-and-error learning was investigated in 17 people with schizophrenia and 18 healthy volunteers and related to striatal grey matter volume and psychopathology.
  
  
  METHODS
  We used voxel-based morphometry and psychophysiological interaction to examine striatal volume and connectivity.
  
  
  RESULTS
  A reduced functional connectivity between left striatum and temporo-occipital areas, precuneus and insula could be detected in the schizophrenia group. The positive correlation between grey matter volume and functional connectivity of the left striatum yielded significant results in a very similar network. Connectivity of the left striatum was negatively correlated with negative symptoms.
  
  
  CONCLUSIONS
  Present results suggest a disruption in striatal functional connectivity that is closely linked to grey matter morphometry of the striatum. Decreased connectivity between the striatum and psychopathologically relevant networks may explain the emergence of negative symptoms.
authors.affiliation: Kathrin Koch, PhD, Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, TUM-Neuroimaging Center (TUM-NIC) of Klinikum rechts der Isar, Technische Universität München TUM, Munich and Graduate School of Systemic Neurosciences GSN, Ludwig-Maximilians-Universität, Biocenter, Munich; Oana Georgiana Rus, MA, Tim Jonas Reeß, MA, Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, TUM-Neuroimaging Center (TUM-NIC) of Klinikum rechts der Isar, Technische Universität München TUM, Munich and Graduate School of Systemic Neurosciences GSN, Ludwig-Maximilians-Universität, Biocenter, Munich; Claudia Schachtzabel, MA, Gerd Wagner, PhD, C. Christoph Schultz, MD, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena; Christian Sorg, MD, Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich; Ralf G. M. Schlösser, Prof. MD, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
authors.forename: Kathrin
authors.initials: K
authors.lastname: Koch
authors.affiliation: Kathrin Koch, PhD, Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, TUM-Neuroimaging Center (TUM-NIC) of Klinikum rechts der Isar, Technische Universität München TUM, Munich and Graduate School of Systemic Neurosciences GSN, Ludwig-Maximilians-Universität, Biocenter, Munich; Oana Georgiana Rus, MA, Tim Jonas Reeß, MA, Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, TUM-Neuroimaging Center (TUM-NIC) of Klinikum rechts der Isar, Technische Universität München TUM, Munich and Graduate School of Systemic Neurosciences GSN, Ludwig-Maximilians-Universität, Biocenter, Munich; Claudia Schachtzabel, MA, Gerd Wagner, PhD, C. Christoph Schultz, MD, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena; Christian Sorg, MD, Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich; Ralf G. M. Schlösser, Prof. MD, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
authors.forename: Oana Georgiana
authors.initials: OG
authors.lastname: Rus
authors.affiliation: Kathrin Koch, PhD, Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, TUM-Neuroimaging Center (TUM-NIC) of Klinikum rechts der Isar, Technische Universität München TUM, Munich and Graduate School of Systemic Neurosciences GSN, Ludwig-Maximilians-Universität, Biocenter, Munich; Oana Georgiana Rus, MA, Tim Jonas Reeß, MA, Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, TUM-Neuroimaging Center (TUM-NIC) of Klinikum rechts der Isar, Technische Universität München TUM, Munich and Graduate School of Systemic Neurosciences GSN, Ludwig-Maximilians-Universität, Biocenter, Munich; Claudia Schachtzabel, MA, Gerd Wagner, PhD, C. Christoph Schultz, MD, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena; Christian Sorg, MD, Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich; Ralf G. M. Schlösser, Prof. MD, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
authors.forename: Tim Jonas
authors.initials: TJ
authors.lastname: Reeß
authors.affiliation: Kathrin Koch, PhD, Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, TUM-Neuroimaging Center (TUM-NIC) of Klinikum rechts der Isar, Technische Universität München TUM, Munich and Graduate School of Systemic Neurosciences GSN, Ludwig-Maximilians-Universität, Biocenter, Munich; Oana Georgiana Rus, MA, Tim Jonas Reeß, MA, Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, TUM-Neuroimaging Center (TUM-NIC) of Klinikum rechts der Isar, Technische Universität München TUM, Munich and Graduate School of Systemic Neurosciences GSN, Ludwig-Maximilians-Universität, Biocenter, Munich; Claudia Schachtzabel, MA, Gerd Wagner, PhD, C. Christoph Schultz, MD, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena; Christian Sorg, MD, Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich; Ralf G. M. Schlösser, Prof. MD, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: Schachtzabel
authors.affiliation: Kathrin Koch, PhD, Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, TUM-Neuroimaging Center (TUM-NIC) of Klinikum rechts der Isar, Technische Universität München TUM, Munich and Graduate School of Systemic Neurosciences GSN, Ludwig-Maximilians-Universität, Biocenter, Munich; Oana Georgiana Rus, MA, Tim Jonas Reeß, MA, Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, TUM-Neuroimaging Center (TUM-NIC) of Klinikum rechts der Isar, Technische Universität München TUM, Munich and Graduate School of Systemic Neurosciences GSN, Ludwig-Maximilians-Universität, Biocenter, Munich; Claudia Schachtzabel, MA, Gerd Wagner, PhD, C. Christoph Schultz, MD, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena; Christian Sorg, MD, Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich; Ralf G. M. Schlösser, Prof. MD, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
authors.forename: Gerd
authors.initials: G
authors.lastname: Wagner
authors.affiliation: Kathrin Koch, PhD, Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, TUM-Neuroimaging Center (TUM-NIC) of Klinikum rechts der Isar, Technische Universität München TUM, Munich and Graduate School of Systemic Neurosciences GSN, Ludwig-Maximilians-Universität, Biocenter, Munich; Oana Georgiana Rus, MA, Tim Jonas Reeß, MA, Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, TUM-Neuroimaging Center (TUM-NIC) of Klinikum rechts der Isar, Technische Universität München TUM, Munich and Graduate School of Systemic Neurosciences GSN, Ludwig-Maximilians-Universität, Biocenter, Munich; Claudia Schachtzabel, MA, Gerd Wagner, PhD, C. Christoph Schultz, MD, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena; Christian Sorg, MD, Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich; Ralf G. M. Schlösser, Prof. MD, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
authors.forename: C Christoph
authors.initials: CC
authors.lastname: Schultz
authors.affiliation: Kathrin Koch, PhD, Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, TUM-Neuroimaging Center (TUM-NIC) of Klinikum rechts der Isar, Technische Universität München TUM, Munich and Graduate School of Systemic Neurosciences GSN, Ludwig-Maximilians-Universität, Biocenter, Munich; Oana Georgiana Rus, MA, Tim Jonas Reeß, MA, Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, TUM-Neuroimaging Center (TUM-NIC) of Klinikum rechts der Isar, Technische Universität München TUM, Munich and Graduate School of Systemic Neurosciences GSN, Ludwig-Maximilians-Universität, Biocenter, Munich; Claudia Schachtzabel, MA, Gerd Wagner, PhD, C. Christoph Schultz, MD, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena; Christian Sorg, MD, Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich; Ralf G. M. Schlösser, Prof. MD, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Sorg
authors.affiliation: Kathrin Koch, PhD, Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, TUM-Neuroimaging Center (TUM-NIC) of Klinikum rechts der Isar, Technische Universität München TUM, Munich and Graduate School of Systemic Neurosciences GSN, Ludwig-Maximilians-Universität, Biocenter, Munich; Oana Georgiana Rus, MA, Tim Jonas Reeß, MA, Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, TUM-Neuroimaging Center (TUM-NIC) of Klinikum rechts der Isar, Technische Universität München TUM, Munich and Graduate School of Systemic Neurosciences GSN, Ludwig-Maximilians-Universität, Biocenter, Munich; Claudia Schachtzabel, MA, Gerd Wagner, PhD, C. Christoph Schultz, MD, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena; Christian Sorg, MD, Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich; Ralf G. M. Schlösser, Prof. MD, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
authors.forename: Ralf G M
authors.initials: RG
authors.lastname: Schlösser
mesh_terms: D000328:Adult; D001931:Brain Mapping; D003342:Corpus Striatum / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D066128:Gray Matter / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009415:Nerve Net / Q000473:pathology* / Q000503:physiopathology; D009434:Neural Pathways / Q000473:pathology / Q000503:physiopathology; D012559:Schizophrenia / Q000473:pathology* / Q000503:physiopathology