title: Endurance training increases brain lactate uptake during hypoglycemia by up regulation of brain lactate transporters.
abstract: The capacity of the brain to metabolize non-glucose substrates under hypoglycemic state maintains its energy requirements. We hypothesized that exercise-induced increase in capacity for brain utilization of lactate by up regulation of the monocarboxylate transporters (MCTs) may contribute metabolic substrates during hypoglycemia in diabetic rats induced by streptozotocin. The induced diabetes increased MCT1 and MCT2 expression in the cortex and the hippocampus in the sedentary diabetic animals. There were exercise-induced increases in MCT1 in the cortex and the hippocampus and MCT2 expression in the cortex in trained diabetic animals; whereas, no changes were found in the healthy trained animals. Both diabetic and healthy trained animals showed higher values for brain lactate uptake during insulin-induced hypoglycemia when animals were intraperitoneally injected by L(+)-lactic acid. However, the response of counterregulatory hormones during hypoglycemia were blunted in the diabetic trained animals which indicates to carefully monitoring of glycemic targets both during and following prolonged exercise.
authors.affiliation: Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran; Department of Exercise Physiology, Faculty of Physical Education and Sport Science, Shahid Bahonar University of Kerman, Kerman, Iran.
authors.forename: Malihe
authors.initials: M
authors.lastname: Aveseh
authors.affiliation: Department of Exercise Physiology, Faculty of Physical Education and Sport Science, Shahid Bahonar University of Kerman, Kerman, Iran. Electronic address: r_nikooie@uk.ac.ir.
authors.forename: Rohollah
authors.initials: R
authors.lastname: Nikooie
authors.affiliation: Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Vahid
authors.initials: V
authors.lastname: Sheibani
authors.affiliation: Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Esmaeili-Mahani
mesh_terms: D000818:Animals; D001692:Biological Transport; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D015870:Gene Expression; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D007003:Hypoglycemia / Q000139:chemically induced / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D007274:Injections, Intraperitoneal; D007328:Insulin; D019344:Lactic Acid / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D027501:Monocarboxylic Acid Transporters / Q000235:genetics / Q000378:metabolism; D009043:Motor Activity; D010805:Physical Conditioning, Animal; D010807:Physical Endurance; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin; D027981:Symporters / Q000235:genetics / Q000378:metabolism; D000099233:Monocarboxylate Transport Protein 1
chemical_list: D007328:Insulin; D019344:Lactic Acid; D027501:Monocarboxylic Acid Transporters; D013311:Streptozocin; D027981:Symporters; D000099233:Monocarboxylate Transport Protein 1; C091633:Slc16a7 protein, rat
keywords: Endurance training; Hypoglycemia; Lactate; Monocarboxylate transporters