title: Adjunctive Orbital Radiotherapy for Ocular Adnexal IgG4-related Disease: Preliminary Experience in Patients Refractory or Intolerant to Corticosteroid Therapy.
abstract: OBJECTIVE
  To present the clinical outcomes of combined orbital radiotherapy and systemic corticosteroid for patients with refractory ocular adnexal IgG4-related disease.
  
  
  METHODS
  We retrospectively reviewed 3 patients with histopathologically confirmed ocular adnexal IgG4-related disease who had been refractory or intolerant to corticosteroid therapy and treated with adjunctive orbital radiotherapy (2000 cGy; 10 fractions). Clinical improvement was assessed by monitoring the patient's ability to taper corticosteroid to discontinuation and by follow-up radiologic examination.
  
  
  RESULTS
  All 3 patients had a favorable response to adjunctive radiotherapy with improvement of the clinical symptoms and radiologic abnormalities. Systemic corticosteroid was tapered and discontinued in all patients successfully. There were no adverse effects of treatment or recurrence after a mean follow-up of 19 months.
  
  
  CONCLUSIONS
  Adjunctive radiotherapy can help to achieve stable disease and cessation of systemic corticosteroid in patients with refractory ocular adnexal IgG4-related disease.
authors.affiliation: Department of Ophthalmology, Taipei Veterans General Hospital and National Yang-Ming University , Taipei , Taiwan and.
authors.forename: Yu-Hao
authors.initials: YH
authors.lastname: Lin
authors.forename: Sang-Hue
authors.initials: SH
authors.lastname: Yen
authors.forename: Chieh-Chih
authors.initials: CC
authors.lastname: Tsai
authors.forename: Shu-Ching
authors.initials: SC
authors.lastname: Kao
authors.forename: Fenq-Lih
authors.initials: FL
authors.lastname: Lee
mesh_terms: D000368:Aged; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D001706:Biopsy; D003937:Diagnosis, Differential; D004361:Drug Tolerance; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D016727:Orbital Pseudotumor / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology / Q000532:radiotherapy; D012189:Retrospective Studies; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D000888:Antibodies, Anti-Idiotypic; D005938:Glucocorticoids; D007074:Immunoglobulin G; C049937:anti-IgA
keywords: Corticosteroid; IgG4-related disease; inflammation; ocular adnexal; radiotherapy