title: [Study on HIV viral load in plasma and drug resistance among AIDS patients receiving antiretroviral treatment in Dehong prefecture,Yunnan province].
abstract: OBJECTIVE
  To understand HIV rival suppression and drug resistance (HIVDR) among AIDS patients who were receiving antiretroviral treatment (ART) in Dehong prefecture, Yunnan province.
  
  
  METHODS
  All AIDS patients who were aged over 15 years and with experience more than six months on ART by the end of 2012 in Dehong prefecture, were enrolled to receive testing for HIV viral load in plasma and genetic mutations associated with HIVDR.
  
  
  RESULTS
  A total of 4 390 AIDS patients were qualified for the study according to the selection criteria, of whom 3 964 (90.3%) finally participated in the study. Among them, 2 307(58.2%) had CD₄(+) cell counts more than 350 cells/mm³. 3 169 (79.9%) patients showed undetectable plasma HIV viral load which was lower than the detection threshold. Those who had the following factors as:resided in Ruili city, being female, older than 45 years of age, married, heterosexually infected with HIV, having received ART more than 5 years, and CD₄(+) cell counts >500 cells/mm³, were more likely to have undetectable plasma virus load, with the differences statistically significant. 402 (10.1%) patients had plasma viral load ≥ 1 000 copies/ml, of whom 353 (87.8%) were successfully amplified and examined for HIVDR. Among them, 198 (56.1% ) were identified to bear genetic mutations associated with HIVDR. Most mutations were related to the resistance to nucleotide reverse transcriptase inhibitors (NNRTIs) or non-nucleotide reverse transcriptase inhibitors (NNRTIs), with M184V and K103N most frequently seen. 12 patients (3.4%) were found to have mutations resistant to protease inhibitors (PI). Data from multiple logistic regression analysis indicated that the period of receiving ART and the initial ART regimen could both significantly predict the occurrence of HIV resistance.
  
  
  CONCLUSIONS
  Viral suppression was highly achieved among ART-prescribed AIDS patients in Dehong prefecture,Yunnan province. However, among those who did not show effective viral suppression, the proportion of HIVDR was high, underscoring the needs for health education so as to improve the adherence to drugs as well as for improving testing for viral load and HIVDR among AIDS patients.
authors.affiliation: Dehong Prefecture Center for Disease Control and Prevention in Yunnan, Mangshi 678400, China.
authors.forename: Shitang
authors.initials: S
authors.lastname: Yao
authors.affiliation: Dehong Prefecture Center for Disease Control and Prevention in Yunnan, Mangshi 678400, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Epidemiology and Key Laboratory of Public Health Safety, School of Public Health, Fudan University.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Dehong Prefecture Center for Disease Control and Prevention in Yunnan, Mangshi 678400, China.
authors.forename: Yanling
authors.initials: Y
authors.lastname: Li
authors.affiliation: Dehong Prefecture Center for Disease Control and Prevention in Yunnan, Mangshi 678400, China.
authors.forename: Jibao
authors.initials: J
authors.lastname: Wang
authors.affiliation: Dehong Prefecture Center for Disease Control and Prevention in Yunnan, Mangshi 678400, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Gao
authors.affiliation: Longchuan County People's Hospital.
authors.forename: Yuanwu
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Yingjiang County People's Hospital.
authors.forename: Wenqin
authors.initials: W
authors.lastname: Yang
authors.affiliation: Ruili City Ethnicity Hospital.
authors.forename: Pinyin
authors.initials: P
authors.lastname: Li
authors.affiliation: Mangshi People's Hospital.
authors.forename: Yun
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Dehong Prefecture People's Hospital.
authors.forename: Yindi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Dehong Prefecture People's Hospital.
authors.forename: Dongdong
authors.initials: D
authors.lastname: Cao
authors.affiliation: Lianghe County People's Hospital.
authors.forename: Meisong
authors.initials: M
authors.lastname: Yang
authors.affiliation: Wanding Hospital.
authors.forename: Zhijian
authors.initials: Z
authors.lastname: Zhai
authors.affiliation: Dehong Prefecture Center for Disease Control and Prevention in Yunnan, Mangshi 678400, China.
authors.forename: Lifen
authors.initials: L
authors.lastname: Xiang
authors.affiliation: Dehong Prefecture Center for Disease Control and Prevention in Yunnan, Mangshi 678400, China.
authors.forename: Yuecheng
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Dehong Prefecture Center for Disease Control and Prevention in Yunnan, Mangshi 678400, China.
authors.forename: Runhua
authors.initials: R
authors.lastname: Ye
authors.affiliation: Department of Epidemiology and Key Laboratory of Public Health Safety,School of Public Health,Fudan University. Email: nhe@shmu.edu.cn.
authors.forename: Na
authors.initials: N
authors.lastname: He
authors.affiliation: Dehong Prefecture Center for Disease Control and Prevention in Yunnan, Mangshi 678400, China. Email: dhduansong@sina.com.cn.
authors.forename: Song
authors.initials: S
authors.lastname: Duan
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D000293:Adolescent; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D024882:Drug Resistance, Viral / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D019562:Viral Load / Q000187:drug effects*; D055815:Young Adult
chemical_list: D019380:Anti-HIV Agents