title: Terahertz pulsed spectroscopy of paraffin-embedded brain glioma.
abstract: The refractive indices, absorption coefficients, and complex dielectric constants of paraffin-embedded brain glioma and normal brain tissues have been measured by a terahertz time-domain spectroscopy (THz-TDS) system in the 0.2- to 2.0-THz range. The spectral differences between gliomas and normal brain tissues were obtained. Compared with normal brain tissue, our results indicate that paraffin-embedded brain gliomas have a higher refractive index, absorption coefficient, and dielectric constant. Based on these results, the best THz frequencies for different methods of paraffin-embedded brain glioma imaging, such as intensity imaging, coherent imaging with continuum THz sources, and THz pulsed imaging with short-pulsed THz sources, are analyzed.
authors.affiliation: China Academy of Engineering Physics, Institute of Fluid Physics, Interdisciplinary Laboratory of Physics and Biomedicine, No. 64, Mianshan Road, Mianyang, Sichuan 621900, ChinabChina Academy of Engineering Physics, Terahertz Research Center, Mianyang, Si.
authors.forename: Kun
authors.initials: K
authors.lastname: Meng
authors.affiliation: China Academy of Engineering Physics, Institute of Fluid Physics, Interdisciplinary Laboratory of Physics and Biomedicine, No. 64, Mianshan Road, Mianyang, Sichuan 621900, ChinacThird Military Medical University, Southwest Hospital, Department of Neurosur.
authors.forename: Tu-nan
authors.initials: TN
authors.lastname: Chen
authors.affiliation: China Academy of Engineering Physics, Institute of Fluid Physics, Interdisciplinary Laboratory of Physics and Biomedicine, No. 64, Mianshan Road, Mianyang, Sichuan 621900, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Chen
authors.affiliation: China Academy of Engineering Physics, Institute of Fluid Physics, Interdisciplinary Laboratory of Physics and Biomedicine, No. 64, Mianshan Road, Mianyang, Sichuan 621900, ChinabChina Academy of Engineering Physics, Terahertz Research Center, Mianyang, Si.
authors.forename: Li-guo
authors.initials: LG
authors.lastname: Zhu
authors.affiliation: China Academy of Engineering Physics, Institute of Fluid Physics, Interdisciplinary Laboratory of Physics and Biomedicine, No. 64, Mianshan Road, Mianyang, Sichuan 621900, ChinabChina Academy of Engineering Physics, Terahertz Research Center, Mianyang, Si.
authors.forename: Qiao
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Third Military Medical University, Southwest Hospital, Department of Neurosurgery, No. 30, Gaotanyan Street, Shapingba, Chongqing 400038, China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Li
authors.affiliation: Third Military Medical University, Southwest Hospital, Department of Neurosurgery, No. 30, Gaotanyan Street, Shapingba, Chongqing 400038, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Li
authors.affiliation: China Academy of Engineering Physics, Institute of Fluid Physics, Interdisciplinary Laboratory of Physics and Biomedicine, No. 64, Mianshan Road, Mianyang, Sichuan 621900, ChinabChina Academy of Engineering Physics, Terahertz Research Center, Mianyang, Si.
authors.forename: Sen-cheng
authors.initials: SC
authors.lastname: Zhong
authors.affiliation: China Academy of Engineering Physics, Institute of Fluid Physics, Interdisciplinary Laboratory of Physics and Biomedicine, No. 64, Mianshan Road, Mianyang, Sichuan 621900, ChinabChina Academy of Engineering Physics, Terahertz Research Center, Mianyang, Si.
authors.forename: Ze-ren
authors.initials: ZR
authors.lastname: Li
authors.affiliation: Third Military Medical University, Southwest Hospital, Department of Neurosurgery, No. 30, Gaotanyan Street, Shapingba, Chongqing 400038, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Feng
authors.affiliation: China Academy of Engineering Physics, Institute of Fluid Physics, Interdisciplinary Laboratory of Physics and Biomedicine, No. 64, Mianshan Road, Mianyang, Sichuan 621900, China.
authors.forename: Jian-heng
authors.initials: JH
authors.lastname: Zhao
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000737:chemistry*; D045744:Cell Line, Tumor; D003952:Diagnostic Imaging / Q000295:instrumentation / Q000379:methods*; D004867:Equipment Design; D005910:Glioma / Q000737:chemistry*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016612:Paraffin Embedding; D012031:Refractometry; D055068:Terahertz Spectroscopy / Q000295:instrumentation / Q000379:methods*