title: Association between bullous pemphigoid and neurologic diseases: a case-control study.
abstract: BACKGROUND
  In the past 10 years, bullous pemphigoid has been associated with other comorbidities and neurologic and psychiatric conditions in particular. Case series, small case-control studies, and large population-based studies in different Asian populations, mainland Europe, and the United Kingdom have confirmed this association. However, no data are available for the Spanish population.
  
  
  METHODS
  This was an observational, retrospective, case-control study with 1:2 matching. Fifty-four patients with bullous pemphigoid were selected. We compared the percentage of patients in each group with concurrent neurologic conditions, ischemic heart disease, diabetes, chronic obstructive pulmonary disease, and solid tumors using univariate logistic regression. An association model was constructed with conditional multiple logistic regression.
  
  
  RESULTS
  The case group had a significantly higher percentage of patients with cerebrovascular accident and/or transient ischemic attack (odds ratio [OR], 3.06; 95% CI, 1.19-7.87], dementia (OR, 5.52; 95% CI, 2.19-13.93), and Parkinson disease (OR, 5; 95% CI, 1.57-15.94). A significantly higher percentage of cases had neurologic conditions (OR, 6.34; 95% CI, 2.89-13.91). Dementia and Parkinson disease were independently associated with bullous pemphigoid in the multivariate analysis.
  
  
  CONCLUSIONS
  Patients with bullous pemphigoid have a higher frequency of neurologic conditions.
authors.affiliation: Servicio de Dermatología. Hospital Universitario Reina Sofía, Córdoba, España. Electronic address: enrique.casas.asun@gmail.com.
authors.forename: E
authors.initials: E
authors.lastname: Casas-de-la-Asunción
authors.affiliation: Servicio de Dermatología. Hospital Universitario Reina Sofía, Córdoba, España.
authors.forename: J
authors.initials: J
authors.lastname: Ruano-Ruiz
authors.affiliation: Servicio de Dermatología. Hospital Universitario Reina Sofía, Córdoba, España.
authors.forename: A M
authors.initials: AM
authors.lastname: Rodríguez-Martín
authors.affiliation: Servicio de Dermatología. Hospital Universitario Reina Sofía, Córdoba, España.
authors.forename: A
authors.initials: A
authors.lastname: Vélez García-Nieto
authors.affiliation: Servicio de Dermatología. Hospital Universitario Reina Sofía, Córdoba, España.
authors.forename: J C
authors.initials: JC
authors.lastname: Moreno-Giménez
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D015897:Comorbidity; D016208:Databases, Factual; D003704:Dementia / Q000453:epidemiology; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D006785:Hospitals, University / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000453:epidemiology; D009369:Neoplasms / Q000453:epidemiology; D009422:Nervous System Diseases / Q000453:epidemiology*; D010300:Parkinson Disease / Q000453:epidemiology; D010391:Pemphigoid, Bullous / Q000453:epidemiology*; D015995:Prevalence; D029424:Pulmonary Disease, Chronic Obstructive / Q000453:epidemiology; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology
keywords: Bullous pemphigoid; Case-control study; Cerebrovascular disease; Demencia; Dementia; Enfermedad cerebrovascular; Enfermedad de Parkinson; Enfermedades del sistema nervioso; Estudios de casos y controles; Nervous system diseases; Parkinson disease; Penfigoide ampolloso