title: Reliability of Clinician Erythema Assessment grading scale.
abstract: BACKGROUND
  Facial erythema is a clinical hallmark of rosacea and often causes social and psychological distress. Although facial erythema assessments are a common endpoint in rosacea clinical trials, their reliability has not been evaluated.
  
  
  OBJECTIVE
  The objective of this study was to evaluate the inter- and intrarater reliability of the Clinician's Erythema Assessment (CEA), a 5-point grading scale of facial erythema severity.
  
  
  METHODS
  Twelve board-certified dermatologists, previously trained on use of the scale, rated erythema of 28 rosacea subjects twice on the same day. Interrater and intrarater agreement was assessed with the intraclass correlation and κ statistic.
  
  
  RESULTS
  The CEA had high interrater reliability and good intrarater reliability with an overall intraclass correlation coefficient (ICC) for session 1 and session 2 of 0.601 and 0.576, respectively; the overall weighted κ statistic for session 1 and session 2 was 0.692.
  
  
  CONCLUSIONS
  Raters were experienced dermatologists and there may be a risk of recall bias.
  
  
  CONCLUSIONS
  When used by trained raters, CEA is a reliable scale for measuring the facial erythema of rosacea.
authors.affiliation: University of Western Ontario, Schulich School of Medicine and Dentistry (Windsor campus), Windsor, Ontario, Canada; Private practice, Windsor, Ontario, Canada.
authors.forename: Jerry
authors.initials: J
authors.lastname: Tan
authors.affiliation: Galderma Research and Development, Princeton, New Jersey.
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
authors.affiliation: University of Pennsylvania, Philadelphia, Pennsylvania.
authors.forename: James J
authors.initials: JJ
authors.lastname: Leyden
authors.affiliation: Galderma Research and Development, Princeton, New Jersey. Electronic address: matthew.leoni@galderma.com.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Leoni
mesh_terms: D000293:Adolescent; D000328:Adult; D002983:Clinical Competence; D015331:Cohort Studies; D003880:Dermatology / Q000379:methods*; D004890:Erythema / Q000175:diagnosis; D005148:Facial Dermatoses / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D015203:Reproducibility of Results; D012393:Rosacea / Q000175:diagnosis*; D012720:Severity of Illness Index; D055815:Young Adult
keywords: Clinician Erythema Assessment; erythema; rating scale; rosacea; scale validation