title: Migraine and obesity: metabolic parameters and response to a weight loss programme.
abstract: OBJECTIVE
  Weight loss can determine significant improvement of migraine in obese patients. Herein, we evaluated a clinical sample of adolescent migraineurs with obesity who participated in an interdisciplinary programme for weight loss, in order to identify possible metabolic parameters associated with good migraine control.
  
  
  METHODS
  Using a cross-sectional design, we evaluated 112 out of 135 adolescents who previously underwent our intervention programme. Based on persistence of headache, subjects for comparison were 40 migraine-free and 72 not migraine-free adolescents. Participants underwent anthropometric evaluations and biochemical tests.
  
  
  RESULTS
  Patients with persistence of migraine had significantly higher weight (P < 0.01), body mass index (P < 0.01), waist circumference (P < 0.01), homeostasis model assessment of insulin resistance (P < 0.001), triglyceride (P < 0.05), total cholesterol (P < 0.05) and low-density lipoprotein cholesterol (P < 0.05) values when compared with those who became migraine-free. Between potential predictors, only insulin resistance (odds ratio = 3.5, 95% confidence interval = 1.4-6.1; P <  0.001) was significantly associated with persistence of migraine after intervention programme.
  
  
  CONCLUSIONS
  Among obese adolescents with migraine who underwent an intervention programme for weight loss, patients who did not become migraine-free showed higher adiposity values than those who became migraine-free. Patients with insulin resistance had 3.5 times the odds of having persistence of migraine compared with those without.
authors.affiliation: Department of Pediatrics, University of Perugia, Perugia, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Verrotti
authors.forename: M
authors.initials: M
authors.lastname: Carotenuto
authors.forename: L
authors.initials: L
authors.lastname: Altieri
authors.forename: P
authors.initials: P
authors.lastname: Parisi
authors.forename: E
authors.initials: E
authors.lastname: Tozzi
authors.forename: V
authors.initials: V
authors.lastname: Belcastro
authors.forename: M
authors.initials: M
authors.lastname: Esposito
authors.forename: N
authors.initials: N
authors.lastname: Guastaferro
authors.forename: A
authors.initials: A
authors.lastname: Ciuti
authors.forename: A
authors.initials: A
authors.lastname: Mohn
authors.forename: F
authors.initials: F
authors.lastname: Chiarelli
authors.forename: S
authors.initials: S
authors.lastname: Agostinelli
mesh_terms: D000293:Adolescent; D000886:Anthropometry; D001521:Behavior Therapy / Q000379:methods*; D015992:Body Mass Index; D002784:Cholesterol; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008077:Lipoproteins, LDL; D008297:Male; D008881:Migraine Disorders / Q000209:etiology* / Q000378:metabolism / Q000628:therapy; D009765:Obesity / Q000150:complications* / Q000378:metabolism / Q000517:prevention & control; D016896:Treatment Outcome; D014280:Triglycerides; D055105:Waist Circumference; D061217:Weight Reduction Programs
chemical_list: D008077:Lipoproteins, LDL; D014280:Triglycerides; D002784:Cholesterol
keywords: insulin resistance; migraine; obesity; weight loss