title: Update in sepsis and pulmonary infections 2013.
abstract: The Journal has been in the vanguard of publications of the respiratory microbiome, including a National Institutes of Health Workshop report, establishing the normal microbiome in patients with various risks, and in the correlation of microbiome changes with disease exacerbations and lung transplant. A new classification scheme for healthcare-associated pneumonia, risks for nosocomial Pseudomonas pneumonia, and associations between community-acquired pneumonia and risks or outcomes have been reported. The increasingly recognized role of viral respiratory tract infections was reflected in publications regarding incidence rates, risk factors, and associations with other respiratory diseases. Significant contributions to understanding and treating sepsis emerged in 2013. The role of tissue damage was highlighted in a series of publications. A much greater understanding of the importance of pathways that directly impact the pathogen at the site of infection and subsequent pathogen clearance has emerged. The Journal published important contributions across the spectrum of ineffective therapy (activated protein C), novel therapeutic ideas (statins and extracorporeal membrane oxygenation), and solidly beneficial approaches (early protocolized care). Biomarker development is maturing to include a wide array of molecular measurements increasingly aimed at aiding improved therapy.
authors.affiliation: 1 Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois; and.
authors.forename: Richard G
authors.initials: RG
authors.lastname: Wunderink
authors.forename: Keith R
authors.initials: KR
authors.lastname: Walley
mesh_terms: D015415:Biomarkers; D017714:Community-Acquired Infections / Q000382:microbiology*; D003428:Cross Infection / Q000209:etiology / Q000382:microbiology* / Q000517:prevention & control; D015658:HIV Infections / Q000382:microbiology*; D006801:Humans; D064307:Microbiota; D011014:Pneumonia / Q000209:etiology / Q000382:microbiology*; D012137:Respiratory System / Q000382:microbiology*; D018805:Sepsis / Q000150:complications / Q000188:drug therapy / Q000382:microbiology*; D054851:Tropheryma / Q000302:isolation & purification / Q000472:pathogenicity; D014481:United States
chemical_list: D015415:Biomarkers
keywords: biomarkers; microbiome; pneumonia; sepsis