title: Geographic atrophy progression in eyes with age-related macular degeneration: role of fundus autofluorescence patterns, fellow eye and baseline atrophy area.
abstract: OBJECTIVE
  To evaluate if fundus autofluorescence (FAF) patterns around geographic atrophy (GA) and the status of the fellow eye have an impact on GA progression.
  
  
  METHODS
  We included 54 eyes of 35 patients with GA. Areas of GA were quantified by RegionFinder software.
  
  
  RESULTS
  GA progression rates in eyes with a diffuse trickling pattern (median 1.42 mm(2)/year) were significantly higher than in normal eyes (median 0.22 mm(2)/year) and eyes with other diffuse FAF patterns (median 0.46 mm(2)/year). Eyes with a banded pattern had a significantly higher progression rate (median 0.81 mm(2)/year) than those without any FAF abnormalities (p = 0.038). The group with baseline total atrophy of the eyes <1 disk area (DA; median 0.42 mm(2)) had an inverse relation with GA progression compared to the groups with baseline atrophy >1 DA (p < 0.05).
  
  
  CONCLUSIONS
  Diffuse trickling and banded patterns may have an impact on GA progression and may serve as prognostic factors.
authors.affiliation: Department of Ophthalmology, Ankara University Faculty of Medicine, Ankara, Turkey.
authors.forename: Figen
authors.initials: F
authors.lastname: Batıoğlu
authors.forename: Yeşim
authors.initials: Y
authors.lastname: Gedik Oğuz
authors.forename: Sibel
authors.initials: S
authors.lastname: Demirel
authors.forename: Emin
authors.initials: E
authors.lastname: Ozmert
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D057092:Geographic Atrophy / Q000175:diagnosis*; D006801:Humans; D008268:Macular Degeneration / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D055213:Retinal Pigment Epithelium / Q000473:pathology