title: Preablation Stimulated Thyroglobulin/TSH Ratio as a Predictor of Successful I(131)Remnant Ablation in Patients with Differentiated Thyroid Cancer following Total Thyroidectomy.
abstract: Background. About 90% of thyroid cancers are differentiated thyroid cancers. Standard treatment is total thyroidectomy followed by radioactive I(131)remnant ablation and TSH suppression with thyroxine. Unsuccessful ablation drastically affects the prognosis of patients with DTC particularly high risk individuals; therefore, identifying the factors that affect the success of ablation is important in the management of patients with DTC. sTg is a good predictor of successful ablation in DTC. Its levels can be influenced by tumor staging and TSH values, as well as other factors. Therefore, we did this study using TSH to correct the predictive value of sTg in success of RRA. Methods. We retrospectively reviewed the records of 75 patients with DTC, who underwent total thyroidectomy followed by RRA and TSH suppression. Results. Preablation sTg and sTg/TSH ratio are significantly associated with ablation outcome. Cutoff value for sTg to predict successful and unsuccessful ablation was 18 ng/mL with 76.7% sensitivity and 79.1% specificity, while for sTg/TSH cutoff was 0.35 with 81.4% sensitivity and 81.5% specificity (P < 0.001). Association was stronger for sTg/TSH ratio with adjusted odds ratio (AOR) 11.64 (2.43-55.61) than for sTg with AOR 5.42 (1.18-24.88). Conclusions. Preablation sTg/TSH ratio can be considered as better predictor of ablation outcome than sTg, tumor size, and capsular invasion.
authors.affiliation: Section of Endocrinology, Department of Medicine, Aga Khan University Hospital, Stadium Road, P.O. Box 3500, Karachi 74800, Pakistan.
authors.forename: Syed
authors.initials: S
authors.lastname: Zubair Hussain
authors.affiliation: Section of Nuclear Medicine, Department of Radiology, Aga Khan University Hospital, P.O. Box 3500, Karachi 74800, Pakistan.
authors.forename: Maseeh Uz
authors.initials: MU
authors.lastname: Zaman
authors.affiliation: Section of Endocrinology, Department of Medicine, Aga Khan University Hospital, Stadium Road, P.O. Box 3500, Karachi 74800, Pakistan.
authors.forename: Sarwar
authors.initials: S
authors.lastname: Malik
authors.affiliation: Section of Endocrinology, Department of Medicine, Aga Khan University Hospital, Stadium Road, P.O. Box 3500, Karachi 74800, Pakistan.
authors.forename: Nanik
authors.initials: N
authors.lastname: Ram
authors.affiliation: Section of Endocrinology, Department of Medicine, Aga Khan University Hospital, Stadium Road, P.O. Box 3500, Karachi 74800, Pakistan.
authors.forename: Ali
authors.initials: A
authors.lastname: Asghar
authors.affiliation: Department of Community Health Sciences, Aga Khan University Hospital, Stadium Road, P.O. Box 3500, Karachi 74800, Pakistan.
authors.forename: Unaib
authors.initials: U
authors.lastname: Rabbani
authors.affiliation: Dow Medical College, P.O. Box 942, Karachi 74200, Pakistan.
authors.forename: Nida
authors.initials: N
authors.lastname: Aftab
authors.affiliation: Section of Endocrinology, Department of Medicine, Aga Khan University Hospital, Stadium Road, P.O. Box 3500, Karachi 74800, Pakistan.
authors.forename: Najmul
authors.initials: N
authors.lastname: Islam