title: Evaluation of cytomegalovirus infection after six months of liver transplantation in children in shiraz, southern iran.
abstract: BACKGROUND
  Liver transplantation (LT) is a life-saving treatment for end-stage liver diseases (ESLD). Cytomegalovirus (CMV) infection is one of the important causes of morbidity after LT.
  
  
  OBJECTIVE
  To evaluate the incidence of late-onset (after 6 months of LT) CMV infection in pediatric recipients.
  
  
  METHODS
  A retrospective analysis was conducted to evaluate 50 pediatric patients who underwent LT for 8 years at the LT Unit of Nemazee Hospital affiliated to Shiraz University of Medical Sciences, Shiraz, Iran. We retrospectively investigated episodes of CMV infection after 6 months of LT proven by CMV antigenemia test.
  
  
  RESULTS
  Three recipients (6%) developed late-onset CMV infection. These patients finally responded to ganciclovir.
  
  
  CONCLUSIONS
  CMV infection is one of the most common post-LT viral infections that usually occurs in the first six months of LT. Our study shows that the incidence of late-onset CMV infection is relatively low, but it still remains a significant problem. Therefore, monitoring and management is crucial for improving the survival of children.
authors.affiliation: Gastroenterohepatology Research Center.
authors.forename: N
authors.initials: N
authors.lastname: Honar
authors.affiliation: Gastroenterohepatology Research Center, ; Shiraz Transplant Research Center.
authors.forename: M H
authors.initials: MH
authors.lastname: Imanieh
authors.affiliation: Gastroenterohepatology Research Center, ; Shiraz Transplant Research Center.
authors.forename: S M
authors.initials: SM
authors.lastname: Dehghani
authors.affiliation: Gastroenterohepatology Research Center.
authors.forename: M
authors.initials: M
authors.lastname: Haghighat
authors.affiliation: Shiraz Transplant Research Center.
authors.forename: B
authors.initials: B
authors.lastname: Geramizadeh
authors.affiliation: Shiraz Transplant Research Center.
authors.forename: R
authors.initials: R
authors.lastname: Yaghobi
authors.affiliation: Clinical Microbiology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: A
authors.initials: A
authors.lastname: Alborzi
authors.affiliation: Clinical Microbiology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Ziaeian
authors.affiliation: Shiraz Transplant Research Center.
authors.forename: K
authors.initials: K
authors.lastname: Kazemi
authors.affiliation: Shiraz Transplant Research Center.
authors.forename: S
authors.initials: S
authors.lastname: Nikeghbalian
authors.affiliation: Shiraz Transplant Research Center.
authors.forename: A
authors.initials: A
authors.lastname: Bahador
authors.affiliation: Shiraz Transplant Research Center.
authors.forename: H
authors.initials: H
authors.lastname: Salahi
authors.affiliation: Shiraz Transplant Research Center.
authors.forename: S A
authors.initials: SA
authors.lastname: Malek Hosseini
keywords: Children; Late-onset cytomegalovirus infection; Liver transplantation