title: A randomized double-blind placebo-controlled study of the efficacy of Clinpro XT varnish and Gluma dentin desensitizer on dentin hypersensitivity.
abstract: OBJECTIVE
  To evaluate the effect of Clinpro XT Varnish (VXT) paste-liquid, resin-modified glass-ionomer and the resinous dentin desensitizing varnish and Gluma Dentin Desensitizer (Gluma) in treating dentin hypersensitivity (DH).
  
  
  METHODS
  This short-term (4-week) randomized, double-blind, placebo-controlled, split-mouth study included a total of 119 teeth from 31 individuals which were randomized into three groups: VXT, Gluma, and placebo (warm water). Dentin sensitivity was evaluated by subjects' perception of DH determined by pretreatment tooth sensitivity score (TSS) measured on a 0-10 visual analogue scale (VAS) after tactile (probe) or thermal/evaporative (blast of air) stimuli. TSS was scored at baseline, immediately after treatment (Day 0), after 1 week and after 4 weeks.
  
  
  RESULTS
  For both stimuli, mean TSS was significantly decreased in the VXT and Gluma groups at all time points (all, P < 0.001) compared with baseline. Regarding comparisons of TSS between treatment groups, the VXT group had significantly lower mean TSS compared with the Gluma group (P< 0.05) and placebo control group (P< 0.05) at all time points after treatment regardless of stimuli. Group Effect, Time Effect, and Group x Time Effect were all significantly different (all, P < 0.001).
authors.forename: Yi-Jian
authors.initials: YJ
authors.lastname: Ding
authors.forename: Hua
authors.initials: H
authors.lastname: Yao
authors.forename: Guo-Hua
authors.initials: GH
authors.lastname: Wang
authors.forename: Hang
authors.initials: H
authors.lastname: Song
mesh_terms: D000328:Adult; D000388:Air; D057133:Dentin Desensitizing Agents / Q000627:therapeutic use*; D003807:Dentin Sensitivity / Q000145:classification / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D005899:Glass Ionomer Cements / Q000627:therapeutic use; D005976:Glutaral / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008689:Methacrylates / Q000627:therapeutic use; D008875:Middle Aged; D010147:Pain Measurement; D010919:Placebos; D019279:Resin Cements / Q000627:therapeutic use; D019237:Tooth Cervix / Q000187:drug effects; D014110:Touch; D016896:Treatment Outcome; D064232:Visual Analog Scale
chemical_list: D057133:Dentin Desensitizing Agents; D005899:Glass Ionomer Cements; D008689:Methacrylates; D010919:Placebos; D019279:Resin Cements; C111486:gluma desensitizer; D005976:Glutaral