title: Maternal/newborn VEGF-C936T interaction and its influence on the risk, severity and prognosis of preeclampsia, as well as on the maternal angiogenic profile.
abstract: OBJECTIVE
  To analyze the influence of maternal/newborn vascular endothelial growth factor (VEGF)-CT936 interaction as a modulating factor in preeclampsia as well as its influence on the maternal angiogenic balance.
  
  
  METHODS
  Seventy pairs of preeclamptic women/newborns and 94 pairs of normal pregnant mothers/newborns were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Serum VEGF and soluble VEGF receptor-1 (sVEGFR-1) levels were measured using ELISA.
  
  
  RESULTS
  The risk to develop mild (odds ratio; OR: 3.79, p = 0.008) and severe (OR: 2.94, p = 0.037) preeclampsia being increased in association with the CT936-VEGF genotype and increased in severe preeclampsia to 6.07 (p = 0.03) if the women were carriers of the homozygous TT936-VEGF genotype. The presence of the VEGF-T936 allele in both the mother and the newborn significantly increases the risk of pregnancy-induced hypertension (PIH), mild and severe preeclampsia. If both the mothers and newborns were carriers of the VEGF-T936 allele, significantly lower VEGF and higher sVEGFR-1 levels were observed for all types of preeclampsia. Pregnant women with PIH and severe preeclampsia delivered at a significantly earlier gestational age neonates with a significantly lower birth weight if both the preeclamptic mothers and their newborns were carriers of the VEGF-T936 allele.
  
  
  CONCLUSIONS
  Our study suggests the role of maternal/fetal VEGF-CT936 polymorphism as a modulating factor in preeclampsia, which affects the angiogenic balance in preeclamptic mothers, as well as their pregnancy outcome.
authors.affiliation: Department of Medical Biochemistry and.
authors.forename: Lucia Maria
authors.initials: LM
authors.lastname: Procopciuc
authors.forename: Gabriela
authors.initials: G
authors.lastname: Caracostea
authors.forename: Gabriela
authors.initials: G
authors.lastname: Zaharie
authors.forename: Florin
authors.initials: F
authors.lastname: Stamatian
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000097:blood / Q000175:diagnosis / Q000235:genetics; D007231:Infant, Newborn; D033261:Maternal-Fetal Relations / Q000502:physiology; D018919:Neovascularization, Physiologic / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis / Q000235:genetics; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000235:genetics; D011379:Prognosis; D012307:Risk Factors; D012720:Severity of Illness Index; D042461:Vascular Endothelial Growth Factor A / Q000097:blood* / Q000235:genetics*; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood; D055815:Young Adult
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D040281:Vascular Endothelial Growth Factor Receptor-1
keywords: Different preeclampsia; VEGF gene polymorphism; VEGF levels; genetic and biochemical risk factor; sVGFR-1 levels; vascular endothelial growth factor