title: Brain peptides and the modulation of postoperative gastric ileus.
abstract: Postoperative ileus (POI) develops after abdominal surgery irrespective of the site of surgery. When prolonged, POI can lead to longer hospitalization times and higher healthcare costs. Moreover, it is associated with complaints for the patient. In order to develop new strategies to treat this condition, a deeper understanding of the pathophysiology of the POI is necessary. This review will focus on brain peptides (ghrelin, nesfatin-1, somatostatin, corticotropin-releasing factor, thyrotropin-releasing hormone and calcitonin gene-related peptide) involved in the mediation of POI and the possible modulation of these pathways to shorten the time of POI. Lastly, the role of vagal signaling or chewing gum as potential treatment strategies of alleviating symptoms of POI is discussed.
authors.affiliation: Charité Center for Internal Medicine and Dermatology, Division of General Internal and Psychosomatic Medicine, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Stengel
authors.affiliation: CURE: Digestive Diseases Research Center, Center for Neurobiology of Stress and Women's Health, Department of Medicine, Digestive Diseases Division at the University of California Los Angeles, and VA Greater Los Angeles Health Care System, CA 90073, USA. Electronic address: ytache@mednet.ucla.edu.
authors.forename: Yvette
authors.initials: Y
authors.lastname: Taché
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D006801:Humans; D045823:Ileus / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D036361:Peptide Hormones / Q000378:metabolism*; D011183:Postoperative Complications / Q000378:metabolism*
chemical_list: D009419:Nerve Tissue Proteins; D036361:Peptide Hormones