title: Superhydrophilic polystyrene nanofiber materials generating O2((1)Δ(g)): postprocessing surface modifications toward efficient antibacterial effect.
abstract: The surfaces of electrospun polystyrene (PS) nanofiber materials with encapsulated 1% w/w 5,10,15,20-tetraphenylporphyrin (TPP) photosensitizer were modified through sulfonation, radio frequency (RF) oxygen plasma treatment, and polydopamine coating. The nanofiber materials exhibited efficient photogeneration of singlet oxygen. The postprocessing modifications strongly increased the wettability of the pristine hydrophobic PS nanofibers without causing damage to the nanofibers, leakage of the photosensitizer, or any substantial change in the oxygen permeability of the inner bulk of the polymer nanofiber. The increase in the surface wettability yielded a significant increase in the photo-oxidation of external polar substrates and in the antibacterial activity of the nanofibers in aqueous surroundings. The results reveal the crucial role played by surface hydrophilicity/wettability in achieving the efficient photo-oxidation of a chemical substrate/biological target at the surface of a material generating O2((1)Δg) with a short diffusion length.
authors.affiliation: Faculty of Sciences, Charles University in Prague , Hlavova 2030, 128 43 Prague 2, Czech Republic.
authors.forename: Petr
authors.initials: P
authors.lastname: Henke
authors.forename: Halyna
authors.initials: H
authors.lastname: Kozak
authors.forename: Anna
authors.initials: A
authors.lastname: Artemenko
authors.forename: Pavel
authors.initials: P
authors.lastname: Kubát
authors.forename: Jitka
authors.initials: J
authors.lastname: Forstová
authors.forename: Jiří
authors.initials: J
authors.lastname: Mosinger
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015169:Colony Count, Microbial; D004058:Diffusion / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D057927:Hydrophobic and Hydrophilic Interactions; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D010084:Oxidation-Reduction / Q000187:drug effects; D010539:Permeability / Q000187:drug effects; D011137:Polystyrenes / Q000737:chemistry*; D026082:Singlet Oxygen / Q000494:pharmacology*; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D011137:Polystyrenes; D026082:Singlet Oxygen