title: Hepatoprotective effect of superfine particles of herbal medicine against CCl4-induced acute liver damage in rats.
abstract: This study aimed to examine the hepatoprotective effects of the superfine particles of Radix Tetrastigma (SPRT) against CCl4-induced acute liver damage in rats. Animals were treated with SPRT (0.3, 0.6, and 1.2 g/kg) and showed remarkable hepatoprotection against CCl4-induced hepatotoxicity. CCl4 altered various biochemical parameters in rat liver, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), malondialdehyde (MDA), superoxide dismutase (SOD), histopathological changes, and Bax and caspase-3 expressions. SPRT significantly prevented increases in ALT and AST levels, reduced MDA level, decreased Bax and caspase-3 protein expression, enhanced SOD activity, and provided significant amelioration in the histopathological lesions. These findings suggested that SPRT has significant protective effect against acute hepatotoxicity induced by CCl4 in rats.
authors.affiliation: Research Center of TCM Processing Technology, Zhejiang Chinese Medical University, Hangzhou 310053, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Cao
authors.affiliation: Zhejiang Cancer Hospital, Hangzhou, China.
authors.forename: Qinglin
authors.initials: Q
authors.lastname: Li
authors.affiliation: The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.
authors.forename: Xiaocheng
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Chinese Materia Medica, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Cai
authors.affiliation: Faculty of Medicine, University of New South Wales, Sydney, NSW 2031, Australia.
authors.forename: Sicong
authors.initials: S
authors.lastname: Tu
mesh_terms: D000208:Acute Disease; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D002251:Carbon Tetrachloride; D053148:Caspase 3 / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D029001:Herbal Medicine; D008099:Liver / Q000201:enzymology / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D010316:Particle Size; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*; D020011:Protective Agents / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism; D051028:bcl-2-Associated X Protein / Q000378:metabolism
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D010936:Plant Extracts; D020011:Protective Agents; D051028:bcl-2-Associated X Protein; D008315:Malondialdehyde; D002251:Carbon Tetrachloride; D013482:Superoxide Dismutase; D053148:Caspase 3