title: [A study of IL-1Β and IDO gene polymorphisms in patients with schizophrenia].
abstract: OBJECTIVE
  Neurotoxic metabolites of the kynurenine pathway are thought to be implicated in the pathogenesis of schizophrenia. The enzyme indoleamine 2,3-dioxygenase (IDO) catalyzes the initial step of the kynurenine pathway that converts tryptophan to kynurenine metabolites. IDO is induced by proinflammatory cytokines. We studied IL-1Β T-511C (rs16944), IL-1Β C3954T (rs1143634), IDO VNTR and IDO rs9657182 polymorphisms in patients with schizophrenia and controls.
  
  
  METHODS
  Genotyping was performed in 296 patients with schizophrenia (ICD-10 F20.0) and 355 healthy controls.
  
  
  RESULTS
  The multiple dimension reduction (MDR) analysis revealed a combination included alleles С (T-511C), Т (C3954T), V1 (VNTR) and С (rs9657182), which was associated with schizophrenia (OR 3,3 CI 95% 2,3-4,8).
  
  
  CONCLUSIONS
  This is the first report of the interaction between IL-1Β and IDO genes. Further research into genes of the kynurenine pathway is needed.
authors.forename: V E
authors.initials: VE
authors.lastname: Golimbet
authors.forename: G I
authors.initials: GI
authors.lastname: Korovaĭtseva
authors.forename: M V
authors.initials: MV
authors.lastname: Gabaeva
authors.forename: N V
authors.initials: NV
authors.lastname: Velikaia
authors.forename: A A
authors.initials: AA
authors.lastname: Snegireva
authors.forename: S V
authors.initials: SV
authors.lastname: Kasparov
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Kolesina
authors.forename: T K
authors.initials: TK
authors.lastname: Ganisheva
authors.forename: T M
authors.initials: TM
authors.lastname: Savel'eva
mesh_terms: D000328:Adult; D000483:Alleles; D005260:Female; D006801:Humans; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000235:genetics*; D053583:Interleukin-1beta / Q000235:genetics* / Q000378:metabolism; D007737:Kynurenine / Q000235:genetics / Q000378:metabolism; D008297:Male; D053858:Metabolic Networks and Pathways / Q000235:genetics; D018598:Minisatellite Repeats; D011110:Polymorphism, Genetic; D012559:Schizophrenia / Q000235:genetics* / Q000378:metabolism; D014364:Tryptophan / Q000235:genetics / Q000378:metabolism; D055815:Young Adult
chemical_list: D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D053583:Interleukin-1beta; D007737:Kynurenine; D014364:Tryptophan