title: Hybrid polymer micelles capable of cRGD targeting and pH-triggered surface charge conversion for tumor selective accumulation and promoted uptake.
abstract: This study presents both tumor-targeting ligands (cRGD) and pH-activated surface charge-conversional moiety (imidazole) decorated micelles for Dox delivery. cRGD is expected to induce preferential tumor accumulation, while imidazole switches on positive charge in a tumor acid environment, which leads to enhanced micelle uptake by tumor cells.
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China. xiez@ciac.ac.cn.
authors.forename: Xiuli
authors.initials: X
authors.lastname: Hu
authors.forename: Xingang
authors.initials: X
authors.lastname: Guan
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Qing
authors.initials: Q
authors.lastname: Pei
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Xie
authors.forename: Xiabin
authors.initials: X
authors.lastname: Jing
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D001692:Biological Transport; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D006863:Hydrogen-Ion Concentration; D007093:Imidazoles / Q000008:administration & dosage / Q000737:chemistry*; D008807:Mice, Inbred BALB C; D008823:Micelles; D009369:Neoplasms / Q000378:metabolism*; D009842:Oligopeptides / Q000008:administration & dosage / Q000737:chemistry*; D011108:Polymers; D013499:Surface Properties
chemical_list: D000903:Antibiotics, Antineoplastic; D007093:Imidazoles; D008823:Micelles; D009842:Oligopeptides; D011108:Polymers; C047981:arginyl-glycyl-aspartic acid; D004317:Doxorubicin