title: Genotype distribution of human papillomavirus in women with abnormal cervical cytology in an esophageal carcinoma high incidence area of China.
abstract: Infection with human papillomavirus (HPV) could affect genesis of both cervical and esophageal cancers. The type-specific distribution of HPV in cervical cytology abnormalities of women has remained unclear in Shantou, an esophageal cancer high-incidence area of China. Data from 22,617 women who were subjected to cervical HPV DNA testing with simultaneous cervical cytological examination during 2009-2013 were therefore here retrospectively evaluated in a hospital-based study. Overall, 16.2% (3,584/22,114)of women with normal cytology were HR-HPV positive, with HPV-52 (4.07%) as the most common type followed by -16 (3.63%), and -58 (2.46%). Prevalence of HR-HPV was 50.3% (253/503) in women with cervical cytological abnormalities, of which in ASC-H 71.4%, ASC-US 39.1%, HSIL 80.3% and LSIL 73.7%. HPV-58 (14.12%) was the most common type for all cervical cytological abnormalities, followed by HPV-16 (13.72%), and -52 (12.72%), while the more common HPV-16 type in ASC-H (42.9%) and HSIL (36.1%), HPV-52 and -58 were the most common types for ASC-US (10.3%) and LSIL (25%), respectively. Multiple HPV co-infections were identified in 33.2% (84/253) cytology abnormalities with positive HR-HPV, and the highest prevalence of HPV-58/16 combination in HSIL (28.6%, 6/21) was observed. Our data indicated a relative high prevalence of HPV-58 and -52 in women with cervical cytological abnormalities, which should be considered in the development of next-generation vaccines for Shantou.
authors.affiliation: Department of Laboratory Medicine, the First Affiliated Hospital of Shantou University Medical College, Shantou, China E-mail : g_ghzhang@stu.edu.cn, g_rqmai@stu.edu.cn.
authors.forename: Rui-Qin
authors.initials: RQ
authors.lastname: Mai
authors.forename: Bo
authors.initials: B
authors.lastname: Huang
authors.forename: Ling
authors.initials: L
authors.lastname: Shen
authors.forename: Guo-Hong
authors.initials: GH
authors.lastname: Zhang
authors.forename: Liang-Li
authors.initials: LL
authors.lastname: Hong
authors.forename: Ying-Mu
authors.initials: YM
authors.lastname: Cai
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics / Q000821:virology; D002681:China / Q000453:epidemiology; D003581:Cytodiagnosis; D004279:DNA, Viral / Q000235:genetics; D004938:Esophageal Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics / Q000821:virology; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics / Q000472:pathogenicity*; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics / Q000821:virology; D015995:Prevalence; D011379:Prognosis; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics / Q000821:virology; D014626:Vaginal Smears; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000821:virology
chemical_list: D004279:DNA, Viral