title: Evaluation of the Quality of Life in Adult Cancer Survivors (QLACS) scale for early post-treatment breast cancer survivors.
abstract: OBJECTIVE
  The end of primary treatment for cancer patients is increasingly recognized as an important time of adjustment that may impact quality of life (QoL). A psychometrically sound QoL instrument that assesses the mix of acute and longer-term concerns present during this unique time has not yet been identified. This article evaluates the Quality of Life in Adult Cancer Survivors (QLACS) scale, originally developed for long-term (>5 years) cancer survivors, as an appropriate QoL measure for this transition period.
  
  
  METHODS
  Psychometric properties of the QLACS were evaluated in a sample of post-treatment breast cancer survivors 18-24 months post-diagnosis. This observational study consisted of women (n = 552) aged 25 years and older (mean = 55.4 years) who were diagnosed with stage I, II, or III breast cancer. The 47 items of the QLACS comprise 12 domains: seven domains are generic, and five are cancer specific.
  
  
  RESULTS
  The QLACS demonstrated adequate internal consistency (Cronbach's alpha for the 12 domains ranged from 0.79 to 0.91) and good convergent and divergent validity (assessed by comparison with the Functional Assessment of Cancer Therapy and other measures).
  
  
  CONCLUSIONS
  The QLACS appears to be consistent with other widely accepted measures in capturing QoL, while also allowing for more inclusive measurement of specific issues relevant to post-treatment cancer survivors. These data, in addition to previous data supporting use of the QLACS across different cancer sites, suggest that the QLACS is a promising comprehensive QoL measure appropriate for breast cancer survivors transitioning off active treatment.
authors.affiliation: Department of Medicine, Vanderbilt University School of Medicine, Sixth Floor, Suite 600, 2525 West End Avenue, Nashville, TN, 37203-1738, USA, Stephanie.Sohl@Vanderbilt.edu.
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: Sohl
authors.forename: Beverly
authors.initials: B
authors.lastname: Levine
authors.forename: Nancy E
authors.initials: NE
authors.lastname: Avis
mesh_terms: D000223:Adaptation, Psychological; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000401:mortality / Q000628:therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D063868:Patient Outcome Assessment; D011594:Psychometrics / Q000379:methods*; D011788:Quality of Life; D018434:Sickness Impact Profile; D012917:Social Adjustment; D011795:Surveys and Questionnaires; D017741:Survivors