title: Nuclear functions of prefoldin.
abstract: Prefoldin is a cochaperone, present in all eukaryotes, that cooperates with the chaperonin CCT. It is known mainly for its functional relevance in the cytoplasmic folding of actin and tubulin monomers during cytoskeleton assembly. However, both canonical and prefoldin-like subunits of this heterohexameric complex have also been found in the nucleus, and are functionally connected with nuclear processes in yeast and metazoa. Plant prefoldin has also been detected in the nucleus and physically associated with a gene regulator. In this review, we summarize the information available on the involvement of prefoldin in nuclear phenomena, place special emphasis on gene transcription, and discuss the possibility of a global coordination between gene regulation and cytoplasmic dynamics mediated by prefoldin.
authors.affiliation: Instituto de Biomedicina de Sevilla, Hospital Virgen del Rocío-CSIC-Universidad de Sevilla, 41013 Seville, Spain Departamento de Genética, Facultad de Biología, Universidad de Sevilla, 41012 Seville, Spain.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Millán-Zambrano
authors.affiliation: Instituto de Biomedicina de Sevilla, Hospital Virgen del Rocío-CSIC-Universidad de Sevilla, 41013 Seville, Spain Departamento de Genética, Facultad de Biología, Universidad de Sevilla, 41012 Seville, Spain schavez@us.es.
authors.forename: Sebastián
authors.initials: S
authors.lastname: Chávez
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D018832:Molecular Chaperones / Q000032:analysis / Q000378:metabolism*; D017510:Protein Folding; D021381:Protein Transport; D015533:Transcriptional Activation
chemical_list: D004268:DNA-Binding Proteins; D018832:Molecular Chaperones; C112806:prefoldin
keywords: chromatin; cytoskeleton; gene transcription; prefoldin; protein folding