title: Protein expression of MMP-2 and MT1-MMP in actinic keratosis, squamous cell carcinoma of the skin, and basal cell carcinoma.
abstract: Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) are 2 skin neoplasms with distinct potentials to invasion and metastasis. Actinic keratosis (AK) is a precursor lesion of SCC. Immunohistochemistry was performed to evaluate the expression of MMP-2 and MT1-MMP in samples of BCC (n = 29), SCC (n = 12), and AK (n = 13). The ratio of positive cells to total cells was used to quantify the staining. Statistical significance was considered under the level P < .05. We found a higher expression of MMP-2 in tumor stroma and parenchyma of SCC as compared to BCC. The expression of this protein was also similar between SCC and its precursor actinic keratosis, and it was higher in the stroma of high-risk BCC when compared to low-risk BCC. MT1-MMP, which is an activator of MMP-2, was similarly expressed in all groups. Our results suggest that MMP-2 expression may contribute to the distinct invasive patterns seen in SCC and BCC.
authors.affiliation: Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil.
authors.forename: Fabiano
authors.initials: F
authors.lastname: de Oliveira Poswar
authors.affiliation: Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil.
authors.forename: Carlos Alberto
authors.initials: CA
authors.lastname: de Carvalho Fraga
authors.affiliation: Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil.
authors.forename: Emisael Stênio Batista
authors.initials: ES
authors.lastname: Gomes
authors.affiliation: Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil.
authors.forename: Lucyana Conceição
authors.initials: LC
authors.lastname: Farias
authors.affiliation: Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil.
authors.forename: Linton Wallis Figueiredo
authors.initials: LW
authors.lastname: Souza
authors.affiliation: Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Sérgio Henrique Souza
authors.initials: SH
authors.lastname: Santos
authors.affiliation: Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Ricardo Santiago
authors.initials: RS
authors.lastname: Gomez
authors.affiliation: Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil.
authors.forename: Alfredo Maurício Batista
authors.initials: AM
authors.lastname: de-Paula
authors.affiliation: Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil andreluizguimaraes@gmail.com.
authors.forename: André Luiz Sena
authors.initials: AL
authors.lastname: Guimarães
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000378:metabolism* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D055623:Keratosis, Actinic / Q000378:metabolism* / Q000473:pathology; D008297:Male; D053511:Matrix Metalloproteinase 14 / Q000378:metabolism*; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D008875:Middle Aged; D060787:Neoplasm Grading; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D020778:Matrix Metalloproteinase 2; D053511:Matrix Metalloproteinase 14
keywords: actinic keratosis; basal cell carcinoma; matrix metalloproteinase-2; membrane-type matrix metalloproteinase-1; squamous cell carcinoma