title: Association of Megsin gene polymorphism with IgA nephropathy risk.
abstract: This meta-analysis was conducted to assess the association of Megsin 2093C/T, 2180C/T, C25663G gene polymorphism with the risk of IgA nephropathy (IgAN). The association literatures were identified from PubMed, Embase, Cochrane Library and CBM-disc (China Biological Medicine Database) on 1 January 2014, and eligible reports were recruited and synthesized. Seven eligible reports were recruited into this meta-analysis for the association of Megsin 2093C/T, 2180C/T, C25663G gene polymorphism with IgAN risk. In this meta-analysis, the association of Megsin 2093C/T TT genotype with IgAN risk in Asians was found. Interestingly, Megsin C25663G G allele and GG genotype were associated with the risk of IgAN in Asian population. However, Megsin 2180C/T gene polymorphism was not associated with IgAN risk in Asians. In conclusion, Megsin 2093C/T TT genotype, and C25663G G allele and GG genotype were associated with the risk of IgAN in Asian population. However, more studies should be performed in the future to confirm this association.
authors.affiliation: Department of Nephrology .
authors.forename: Tian-Biao
authors.initials: TB
authors.lastname: Zhou
authors.forename: Xiao-Neng
authors.initials: XN
authors.lastname: Mo
authors.forename: Qiu-Ye
authors.initials: QY
authors.lastname: Kou
authors.forename: Zong-Pei
authors.initials: ZP
authors.lastname: Jiang
authors.forename: Meng-Ran
authors.initials: MR
authors.lastname: Xiong
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005922:Glomerulonephritis, IGA / Q000235:genetics* / Q000473:pathology; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D015843:Serpins / Q000235:genetics*
chemical_list: C114170:SERPINB7 protein, human; D015843:Serpins
keywords: 2093C/T; 2180C/T; C25663G; Gene polymorphism; IgA nephropathy; megsin; meta-analysis