title: Does a thrombin-based topical haemostatic agent reduce blood loss and transfusion requirements after total knee revision surgery? A randomized, controlled trial.
abstract: OBJECTIVE
  The aim of the present study was to assess the efficacy of a thrombin-based topical haemostatic in reducing blood requirements after total knee replacement (TKR) revision surgery.
  
  
  METHODS
  This prospective, randomized, controlled study was designed to evaluate the haemostatic efficacy and safety of a thrombin-based topical haemostatic (Floseal) versus standard treatment in patients receiving total knee revision arthroplasty. The decrease in haemoglobin values postsurgery and the blood units transfused were recorded. The decision to transfuse was made by a surgeon blinded to the patient's group allocation.
  
  
  RESULTS
  Forty-eight patients were enroled in the study; twenty-four patients each were randomized to the treatment and control groups, respectively. The median decrease in haemoglobin concentration on the first postoperative day was 2.2 g/dL in the treatment group and 2.7 g/dL in the control group. A significant reduction in units of blood transfused was also observed in the treatment group compared with the control group [1.1 ± 1.13 (range 0-4) vs. 1.9 ± 1.41 (range 0-5) blood units; P = 0.04]. No major treatment-related adverse events were recorded in the study.
  
  
  CONCLUSIONS
  This study shows that a thrombin-based topical haemostatic reduces the need for blood transfusion in TKR revision surgery.
  
  
  CONCLUSIONS
  A thrombin-based topical haemostatic agent can be an appropriate solution to enhance haemostasis and vessel sealing at the operative site in TKR revision surgery, in order to reduce the need for blood transfusion after surgery.
  
  
  METHODS
  II.
authors.affiliation: Department of Bone and Joint Infections and Reconstructive Surgery, IRCCS Orthopaedic Institute Galeazzi, Via Riccardo Galeazzi 4, 20161, Milan, Italy. carlo.romano@grupposandonato.it.
authors.forename: Carlo L
authors.initials: CL
authors.lastname: Romanò
authors.affiliation: Department of Bone and Joint Infections and Reconstructive Surgery, IRCCS Orthopaedic Institute Galeazzi, Via Riccardo Galeazzi 4, 20161, Milan, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Monti
authors.affiliation: Department of Bone and Joint Infections and Reconstructive Surgery, IRCCS Orthopaedic Institute Galeazzi, Via Riccardo Galeazzi 4, 20161, Milan, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Logoluso
authors.affiliation: Department of Bone and Joint Infections and Reconstructive Surgery, IRCCS Orthopaedic Institute Galeazzi, Via Riccardo Galeazzi 4, 20161, Milan, Italy.
authors.forename: Delia
authors.initials: D
authors.lastname: Romanò
authors.affiliation: Laboratory of Clinical Chemistry and Microbiology, IRCCS Orthopedic Institute Galeazzi, Via Riccardo Galeazzi 4, 20161, Milan, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Drago
mesh_terms: D000287:Administration, Topical; D000368:Aged; D000369:Aged, 80 and over; D019645:Arthroplasty, Replacement, Knee; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D001803:Blood Transfusion; D005260:Female; D005781:Gelatin Sponge, Absorbable / Q000008:administration & dosage*; D006454:Hemoglobins / Q000032:analysis; D006490:Hemostatics / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019106:Postoperative Hemorrhage / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D011446:Prospective Studies; D012086:Reoperation; D013917:Thrombin / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: C411004:FloSeal Matrix; D006454:Hemoglobins; D006490:Hemostatics; D013917:Thrombin
keywords: Floseal; Revision arthroplasty; Thrombin-based topical haemostatic; Total knee replacement; Transfusion