title: Integrins and epithelial cell polarity.
abstract: Cell polarity is characterised by differences in structure, composition and function between at least two poles of a cell. In epithelial cells, these spatial differences allow for the formation of defined apical and basal membranes. It has been increasingly recognised that cell-matrix interactions and integrins play an essential role in creating epithelial cell polarity, although key gaps in our knowledge remain. This Commentary will discuss the mounting evidence for the role of integrins in polarising epithelial cells. We build a model in which both inside-out signals to polarise basement membrane assembly at the basal surface, and outside-in signals to control microtubule apical-basal orientation and vesicular trafficking are required for establishing and maintaining the orientation of epithelial cell polarity. Finally, we discuss the relevance of the basal integrin polarity axis to cancer. This article is part of a Minifocus on Establishing polarity.
authors.affiliation: Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK.
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Lee
authors.affiliation: Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK cstreuli@manchester.ac.uk.
authors.forename: Charles H
authors.initials: CH
authors.lastname: Streuli
mesh_terms: D000818:Animals; D001485:Basement Membrane / Q000378:metabolism*; D016764:Cell Polarity; D004847:Epithelial Cells / Q000502:physiology*; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism; D009369:Neoplasms / Q000473:pathology / Q000503:physiopathology*
chemical_list: D016023:Integrins
keywords: +TIPS; Basement membrane; Breast; Endocytosis; Epithelium; ILK; Integrin; Laminin; Mammary; Microtubule; Polarity