title: Recurrent temporary paralysis reported after human rabies post-exposure prophylaxis.
abstract: Adverse events can occur after rabies post-exposure prophylaxis (PEP), and linkage to causality is often difficult to determine. We report a case of recurrent temporary paralysis that began immediately after the initiation of rabies PEP in a man exposed to a bat. The recurrent temporary paralysis first occurred in the patient after his initial dose and then again after day 3 of his rabies PEP. The PEP was terminated prior to a serologic response. The patient continued to experience numerous discrete episodes of temporary paralysis for over two years.
authors.affiliation: Pennsylvania Department of Health, Bureau of Epidemiology, Harrisburg, PA, USA.
authors.forename: V M
authors.initials: VM
authors.lastname: Dato
authors.forename: E R
authors.initials: ER
authors.lastname: Campagnolo
authors.forename: D U
authors.initials: DU
authors.lastname: Shah
authors.forename: M J
authors.initials: MJ
authors.lastname: Bellush
authors.forename: C E
authors.initials: CE
authors.lastname: Rupprecht
mesh_terms: D000818:Animals; D006801:Humans; D008297:Male; D008875:Middle Aged; D010243:Paralysis / Q000139:chemically induced*; D056990:Post-Exposure Prophylaxis; D011818:Rabies / Q000276:immunology / Q000517:prevention & control*; D011819:Rabies Vaccines / Q000009:adverse effects*; D011820:Rabies virus / Q000276:immunology*
chemical_list: D011819:Rabies Vaccines
keywords: Post-exposure prophylaxis; bat; bat-variant rabies; human diploid cell vaccine; human rabies immunoglobulin; purified chick embryo cell vaccine; rabies; rabies exposure; rabies immunization; recurrent temporary paralysis