title: The effects of topical antiglaucoma drugs as monotherapy on the ocular surface: a prospective study.
abstract: Purpose. The aim was to compare the effects of antiglaucoma eye drops on the tear functions and ocular surface. Method. Eighty-five eyes of 43 patients with glaucoma were included into this randomized prospective study. Timolol without preservative (1), timolol with benzododecinium bromide (2), latanoprost (3), bimatoprost (4), travoprost with benzalkonium chloride (5), and brimonidine with purite (6) were given to 6 groups. Schirmer I, tear film breakup time (TBUT), staining scores, and impression cytology samples were evaluated before and during 12-month-follow-up period. Results. At the end of 12 months, there was no detected change in Schirmer I and TBUT tests indicating dry eye. Corneal staining scores were higher in groups 1 and 2, while conjunctival staining scores were higher in group 6. Goblet cell count decreased in groups 1 and 5 in superior and inferior, group 2 in superior, and groups 3 and 6 in inferior conjunctiva. Squamous metaplasia grades showed a significant increase in groups 1 and 2 at 3rd, 6th, and 12th month controls (P < 0.05). Conclusion. We observed nonserious impact on tear functions and ocular surface with antiglaucoma monotherapy. Beta blockers induced more damage on the ocular surface suggesting the role of the dosing and active substances beside preservatives.
authors.affiliation: Fatih Sultan Mehmet Education and Research Hospital, Ophthalmology Clinics, 34758 Istanbul, Turkey.
authors.forename: Sevda
authors.initials: S
authors.lastname: Aydin Kurna
authors.affiliation: Fatih Sultan Mehmet Education and Research Hospital, Ophthalmology Clinics, 34758 Istanbul, Turkey.
authors.forename: Semih
authors.initials: S
authors.lastname: Acikgoz
authors.affiliation: Fatih Sultan Mehmet Education and Research Hospital, Ophthalmology Clinics, 34758 Istanbul, Turkey.
authors.forename: Ahmet
authors.identifier: 0000-0001-8056-0611
authors.initials: A
authors.lastname: Altun
authors.affiliation: Fatih Sultan Mehmet Education and Research Hospital, Pathology Clinics, 34758 Istanbul, Turkey.
authors.forename: Nurver
authors.initials: N
authors.lastname: Ozbay
authors.affiliation: Bilim University, Florence Nightingale Hospital, Ophthalmology Clinics, 34724 Istanbul, Turkey.
authors.forename: Tomris
authors.initials: T
authors.lastname: Sengor
authors.affiliation: Erzurum Region Education and Research Hospital, Ophthalmology Clinics, 25000 Erzurum, Turkey.
authors.forename: Osman Okan
authors.initials: OO
authors.lastname: Olcaysu