title: Low antibody-dependent cellular cytotoxicity responses in Zambians prior to HIV-1 intrasubtype C superinfection.
abstract: We have previously shown that HIV-1 superinfected Zambian seroconverters mount low binding and neutralizing antibody responses to their primary HIV-1 infecting virus, which could increase susceptibility to re-infection. Here, we investigated if antibody-dependent cellular cytotoxicity (ADCC), a process by which virus-infected cells are killed, was also reduced. Superinfected individuals exhibited low ADCC activity compared to non-superinfected individuals, but similar levels of CMV-reactive binding antibodies, suggesting superinfected individuals are capable of generating and maintaining virus-specific antibodies.
authors.affiliation: Emory Vaccine Center at Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA. Electronic address: dbasu@emory.edu.
authors.forename: Debby
authors.initials: D
authors.lastname: Basu
authors.affiliation: Emory Vaccine Center at Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA. Electronic address: peng.xiao@emory.edu.
authors.forename: Peng
authors.initials: P
authors.lastname: Xiao
authors.affiliation: Emory Vaccine Center at Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA. Electronic address: zachary.s.ende@emory.edu.
authors.forename: Zachary
authors.initials: Z
authors.lastname: Ende
authors.affiliation: Emory Vaccine Center at Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA. Electronic address: alfred.bere@emory.edu.
authors.forename: Alfred
authors.initials: A
authors.lastname: Bere
authors.affiliation: University of Alabama - Birmingham, 1600 7th Avenue South, Children׳s Harbor Building 107, Birmingham, AL 35233-1711, USA. Electronic address: WBritt@peds.uab.edu.
authors.forename: William J
authors.initials: WJ
authors.lastname: Britt
authors.affiliation: Zambia Emory HIV Research Project (ZEHRP), B22/737 Mwembelelo, Emmasdale, Post Net 412; P/BagE891, Zambia. Electronic address: joseph.mulenga@znbts.gov.zm.
authors.forename: Joseph
authors.initials: J
authors.lastname: Mulenga
authors.affiliation: Zambia Emory HIV Research Project (ZEHRP), B22/737 Mwembelelo, Emmasdale, Post Net 412; P/BagE891, Zambia. Electronic address: wkilembe@rzhrg-mail.org.
authors.forename: William
authors.initials: W
authors.lastname: Kilembe
authors.affiliation: Zambia Emory HIV Research Project (ZEHRP), B22/737 Mwembelelo, Emmasdale, Post Net 412; P/BagE891, Zambia; Department of Global Health, Rollins School of Public Health, Emory University, 1518 Clifton Rd NE, Atlanta, GA 30322, USA; Department of Pathology and Laboratory Medicine, Emory University, 101, Woodruff Circle, Atlanta, GA 30322, USA. Electronic address: SALLEN5@emory.edu.
authors.forename: Susan A
authors.initials: SA
authors.lastname: Allen
authors.affiliation: Emory Vaccine Center at Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA; Department of Pathology and Laboratory Medicine, Emory University, 101, Woodruff Circle, Atlanta, GA 30322, USA. Electronic address: cderdey@emory.edu.
authors.forename: Cynthia A
authors.initials: CA
authors.lastname: Derdeyn
authors.affiliation: Emory Vaccine Center at Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA; Department of Pathology and Laboratory Medicine, Emory University, 101, Woodruff Circle, Atlanta, GA 30322, USA. Electronic address: ehunte4@emory.edu.
authors.forename: Eric
authors.initials: E
authors.lastname: Hunter
mesh_terms: D015483:HIV Antibodies / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology* / Q000821:virology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D015163:Superinfection / Q000276:immunology*
chemical_list: D015483:HIV Antibodies
keywords: ADCC; HIV dual infection; HIV-1 ADCC; HIV-1 superinfection