title: Anti-diarrhoeal investigation from aqueous extract of Cuminum cyminum Linn. Seed in Albino rats.
abstract: BACKGROUND
  Cuminum cyminum Linn. (Umbelliferae), commonly known as Jeera. It is native from mediterranean region, but today widely cultivated in Asian countries. It has been reported to possess various medicinal properties and an important food ingredient. The seed of the plant are claimed for treatment of diarrhoea by various traditional practitioners.
  
  
  OBJECTIVE
  Hence, the present investigation was undertaken to evaluate aq. extract of C. cyminum seeds (ACCS) against diarrhoea on albino rats.
  
  
  METHODS
  The animals were divided into five groups and the control group was applied with 2% acacia suspension, the standard group with loperamide (3 mg/kg) or atropine sulphate (5mg/kg) and three test groups administered orally with 100, 250 and 500 mg/kg of ACCS. The antidiarrhoeal effect was investigated by castor oil induce diarrhoea model, prostaglandin E2 (PGE2) induced enteropooling model, intestinal transit by charcoal meal test.
  
  
  RESULTS
  The ACCS showed significant (P < 0.001) inhibition in frequency of diarrhoea, defecation time delaying, secretion of intestinal fluid as well as intestinal propulsion as compared to control and the graded doses of tested extract followed dose dependent protection against diarrhoea.
  
  
  CONCLUSIONS
  The study reveals that the ACCS is a potent antidiarrhoeal drug which supports the traditional claim.
authors.affiliation: Department of Pharmacology and Experimental Biology, Vedica College of Pharmacy, RKDF University, Bhopal, Madhya Pradesh, India.
authors.forename: Himanshu Bhusan
authors.initials: HB
authors.lastname: Sahoo
authors.affiliation: Department of Pharmaceutical Chemistry, Sri Sivani College of Pharmacy, Srikakulam, Andhra Pradesh, India.
authors.forename: Saroj Kumar
authors.initials: SK
authors.lastname: Sahoo
authors.affiliation: Department of Pharmaceutical Chemistry, Jayamukhi Institute of Pharmaceutical Science, Warangal, Andhra Pradesh, India.
authors.forename: Sarada Prasad
authors.initials: SP
authors.lastname: Sarangi
authors.affiliation: Department of Pharmacognosy and Phytochemistry, Sri Satya Sai Institute of Pharmaceutical Sciences, Bhopal, Madhya Pradesh, India.
authors.forename: Rakesh
authors.initials: R
authors.lastname: Sagar
authors.affiliation: Department of Pharmacognosy and Phytochemistry, Vedica College of Pharmacy, RKDF University, Bhopal, Madhya Pradesh, India.
authors.forename: Mohan Lal
authors.initials: ML
authors.lastname: Kori
keywords: Antidiarrhoeal effect; Intestinal transit; castor oil; enteropooling model; seed