title: Omega-3 fatty acids and the genetic risk of early onset acute coronary syndrome.
abstract: OBJECTIVE
  Recent gene-environment interaction studies suggest that diet may influence an individual's genetic predisposition to cardiovascular risk. We evaluated whether omega-3 fatty acid intake may influence the risk for acute coronary syndrome (ACS) conferred by genetic polymorphisms among patients with early onset ACS.
  
  
  RESULTS
  Our population consisted of 705 patients of white European descent enrolled in GENESIS-PRAXY, a multicenter cohort study of patients aged 18-55 years and hospitalized with ACS. We used a case-only design to investigate interactions between the omega-3 index (a validated biomarker of omega-3 fatty acid intake) and 30 single nucleotide polymorphisms (SNPs) robustly associated with ACS. We used logistic regression to assess the interaction between each SNP and the omega-3 index. Interaction was also assessed between the omega-3 index and a genetic risk score generated from the 30 SNPs. All models were adjusted for age and sex. An interaction for increased ACS risk was found between carriers of the chromosome 9p21 variant rs4977574 and low omega-3 index (OR 1.57, 95% CI 1.07-2.32, p = 0.02), but this was not significant after correction for multiple testing. Similar results were obtained in the adjusted model (OR 1.55, 95% CI 1.05-2.29, p = 0.03). We did not observe any interaction between the genetic risk score or any of the other SNPs and the omega-3 index.
  
  
  CONCLUSIONS
  Our results suggest that omega-3 fatty acid intake may modify the genetic risk conferred by chromosome 9p21 variation in the development of early onset ACS and requires independent replication.
authors.affiliation: Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada; Division of Clinical Epidemiology, Research Institute of McGill University Health Centre, Montreal, Quebec, Canada.
authors.forename: S S L
authors.initials: SS
authors.lastname: Leung Yinko
authors.affiliation: Division of Clinical Epidemiology, Research Institute of McGill University Health Centre, Montreal, Quebec, Canada; Division of Cardiology, McGill University Health Centre, Montreal, Quebec, Canada.
authors.forename: G
authors.initials: G
authors.lastname: Thanassoulis
authors.affiliation: Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada.
authors.forename: K D
authors.initials: KD
authors.lastname: Stark
authors.affiliation: Division of Clinical Epidemiology, Research Institute of McGill University Health Centre, Montreal, Quebec, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Avgil Tsadok
authors.affiliation: Department of Medicine, McGill University, Montreal, Quebec, Canada; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.
authors.forename: J C
authors.initials: JC
authors.lastname: Engert
authors.affiliation: Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada; Division of Clinical Epidemiology, Research Institute of McGill University Health Centre, Montreal, Quebec, Canada; Division of General Internal Medicine, McGill University Health Centre, Montreal, Quebec, Canada. Electronic address: louise.pilote@mcgill.ca.
authors.forename: L
authors.initials: L
authors.lastname: Pilote
mesh_terms: D054058:Acute Coronary Syndrome / Q000453:epidemiology / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics; D015331:Cohort Studies; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D005260:Female; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D015203:Reproducibility of Results; D012307:Risk Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers; D015525:Fatty Acids, Omega-3
keywords: Diet; Genes; Genetics; Lipids; Nutrition