title: Pregnancy after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in pseudomyxoma peritonei.
abstract: Pseudomyxoma peritonei is usually a benign tumor that is slightly more common in women. However, it requires aggressive surgical treatment and chemotherapy, often compromising future reproductive function. This report presents a case of pregnancy in a 35-year-old woman who underwent cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for treatment of pseudomyxoma peritonei. The tumor was diagnosed during a laparoscopic examination on a workup for infertility in 2008. Two months later, she underwent a peritonectomy followed by hyperthermic intraperitoneal chemotherapy and, regarding her will to conceive, ovaries and fallopian tubes were preserved. In March 2011, she went through an in vitro fertilization followed by an uneventful pregnancy and delivered a healthy child 39 weeks later. Ovaries are usually resected during the cytoreductive surgery, since they are common sites for neoplastic implants, and, even when not performed, little is known about the effects of local chemotherapy on female fertility. The largest international survey on this matter only describes seven similar cases. This particular report not only describes a rare condition but also adds to the upcoming discussion about whether ovaries can be preserved in specific situations, therefore keeping the prospect of conceiving after this treatment.
authors.affiliation: Division of Colorectal Surgery, Alfa Institute of Gastroenterology, Hospital das Clínicas, School of Medicine, Universidade Federal de Minas Gerais, Avenida Alfredo Balena 110, 30130-100 Belo Horizonte, MG, Brazil.
authors.forename: Renato Gomes
authors.initials: RG
authors.lastname: Campanati
authors.affiliation: Division of Colorectal Surgery, Alfa Institute of Gastroenterology, Hospital das Clínicas, School of Medicine, Universidade Federal de Minas Gerais, Avenida Alfredo Balena 110, 30130-100 Belo Horizonte, MG, Brazil.
authors.forename: Bernardo
authors.initials: B
authors.lastname: Hanan
authors.affiliation: Division of Gynecology and Obstetrics, School of Medicine, Federal University of Minas Gerais, Avenida Alfredo Balena 110, 30130-100 Belo Horizonte, MG, Brazil.
authors.forename: Sérgio Simões
authors.initials: SS
authors.lastname: de Souza
authors.affiliation: Division of Colorectal Surgery, Alfa Institute of Gastroenterology, Hospital das Clínicas, School of Medicine, Universidade Federal de Minas Gerais, Avenida Alfredo Balena 110, 30130-100 Belo Horizonte, MG, Brazil.
authors.forename: Rodrigo
authors.identifier: 0000-0002-0613-4726
authors.initials: R
authors.lastname: Gomes da Silva