title: An overview of live attenuated recombinant pseudorabies viruses for use as novel vaccines.
abstract: Pseudorabies virus (PRV) is a double-stranded, DNA-based swine virus with a genome approximating 150 kb in size. PRV has many nonessential genes which can be replaced with genes encoding heterologous antigens but without deleterious effects on virus propagation. Recombinant PRVs expressing both native and foreign antigens are able to stimulate immune responses. In this paper, we review the current status of live attenuated recombinant PRVs and live PRV-based vector vaccines with potential for controlling viral infections in animals.
authors.affiliation: Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, 59 Mucai Street, Xiangfang District, Harbin 150030, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Dong
authors.affiliation: Animal Parasitic Diseases Laboratory, Agricultural Research Service, Beltsville, MD 20705, USA.
authors.forename: Dante S
authors.initials: DS
authors.lastname: Zarlenga
authors.affiliation: Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, 59 Mucai Street, Xiangfang District, Harbin 150030, China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Ren
mesh_terms: D000818:Animals; D005822:Genetic Vectors / Q000235:genetics / Q000276:immunology; D011558:Herpesvirus 1, Suid / Q000235:genetics / Q000276:immunology*; D011557:Pseudorabies / Q000276:immunology* / Q000517:prevention & control*; D022421:Pseudorabies Vaccines / Q000235:genetics / Q000276:immunology*; D013552:Swine; D013553:Swine Diseases / Q000276:immunology / Q000517:prevention & control; D014613:Vaccines, Attenuated
chemical_list: D022421:Pseudorabies Vaccines; D014613:Vaccines, Attenuated