title: [Meta-analysis of total thyroidectomy for multinodular goiter].
abstract: OBJECTIVE
  To systematically evaluate the efficiency and safety of total thyroidetomy (including near-total tyhroidectomy) versus subtotal thyroidectomy for multinodular goiter.
  
  
  METHODS
  The literatures were searched from Cochrane Library, PubMed, Embase, Chinese Biological Medical Datebase, Chinese National Knowledge Infrastructure, and Chinese Science and Technology Journal Full-text Database as of November 2013. We included all randomizad controlled trials on total (including near-total) versus subtotal thyroidectomy in the treatment of multinodular goiter. The collecting of data and quality assessment were respectively completed by 2 researchers. RevMan5.1 software was used for Meta-analysis.
  
  
  RESULTS
  We collected 7 literatures conforming to the standard, incuding 2 192 patients. The Metaanalysis outcomes showed that total thyroidectomy was associated with lower nodule recurrence rate (OR=0.13, 95% CI: 0.07-0.22, P<0.001) and higher in transient hypoparathyroidism rate (OR=2.33, 95% CI: 1.72-3.17, P<0.001). However, no statistical difference was seen comparing total and subtotal thyroidectomy in permanent recurrent laryngeal nerve paralysis rate (OR= 0.81, 95% CI: 0.24-2.74, P=0.74) and permanent hypoparathyroidism rate (OR=2.94, 95% CI: 0.48- 18.11, P=0.24).
  
  
  CONCLUSIONS
  Nodule recurrence rate of total thyroidectomy for multinodular goiter is lower than subtotal thyroidectomy and does not increase permanent complications.
authors.affiliation: Department of General Surgery, Second Hospital of Lanzhou University, Lanzhou 730030; Key Laboratory of Digestive System Tumors of Gansu Province, Lanzhou 730030, China.
authors.forename: Hongtai
authors.initials: H
authors.lastname: Cao
authors.forename: Jixiang
authors.initials: J
authors.lastname: Han
authors.forename: Donghong
authors.initials: D
authors.lastname: Zhang
authors.forename: Zeyuan
authors.initials: Z
authors.lastname: Yu
authors.forename: Mancai
authors.initials: M
authors.lastname: Wang
authors.forename: Zuoyi
authors.initials: Z
authors.lastname: Jiao
mesh_terms: D006044:Goiter, Nodular / Q000601:surgery*; D006801:Humans; D007011:Hypoparathyroidism; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence; D013965:Thyroidectomy / Q000379:methods*; D014826:Vocal Cord Paralysis