title: Unilateral olfactory deficit in a hemiparkinson's disease mouse model.
abstract: Parkinson's disease is a neurodegenerative disease which often presents hyposmia (80-90% of the cases). We characterized the olfactory behavior in the model of 6-hydroxydopamine of Parkinson's disease. Mice were trained to discriminate between two odorants in a radial maze. One of the odorants was associated with water as a reward. 6-hydroxydopamine was injected directly into the dorsal striatum; after complete striatal denervation, olfactory performance was evaluated in a radial maze. In the first evaluation, experimental mice performed as control mice. After the first evaluation, the narine of the contralateral side to the striatal injection was closed and mice were evaluated again. The experimental group completely lost the capacity to discriminate between the odorant associated with the reward (heptaldehyde) and the unconditioned odorant (2-heptanone). We propose that the olfactory deficit was caused by dopaminergic denervation to the olfactory tubercle and nucleus accumbens.
authors.affiliation: Department of Molecular Neuropathology, Institute of Cellular Physiology, National Autonomous University of Mexico, Mexico D.F., Mexico.
authors.forename: Pablo
authors.initials: P
authors.lastname: Valle-Leija
authors.forename: René
authors.initials: R
authors.lastname: Drucker-Colín
mesh_terms: D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D003342:Corpus Striatum / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology*; D004192:Discrimination, Psychological / Q000502:physiology*; D004195:Disease Models, Animal; D007839:Functional Laterality; D007150:Immunohistochemistry; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009483:Neuropsychological Tests; D055696:Olfactory Perception / Q000502:physiology*; D016627:Oxidopamine; D020734:Parkinsonian Disorders / Q000473:pathology / Q000503:physiopathology* / Q000523:psychology*; D012201:Reward
chemical_list: D000697:Central Nervous System Stimulants; D016627:Oxidopamine; D000661:Amphetamine