title: Pre-clinical optical imaging and MRI for drug development in Alzheimer's disease.
abstract: Optical and magnetic resonance imaging have the potential to be complementary non-invasive imaging modalities. Yet without advances in imaging technologies and contrast agents both have short-comings that cannot be ignored. In this review we demonstrate the pre-clinical use of the two imaging techniques in Alzheimer's disease, including examples from recent applications and discuss what is needed to improve their applicability for drug discovery.:
authors.affiliation: Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:m.rotman@lumc.nl.
authors.forename: Maarten
authors.initials: M
authors.lastname: Rotman
authors.affiliation: Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: Thomas J A
authors.initials: TJ
authors.lastname: Snoeks
authors.affiliation: Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: Louise
authors.initials: L
authors.lastname: van der Weerd