title: A comparative study of two polymorphs of L-aspartic acid hydrochloride.
abstract: Two polymorphs of L-aspartic acid hydrochloride, C4H8NO4(+)·Cl(-), were obtained from the same aqueous solution. Their crystal structures have been determined from single-crystal data collected at 100 K. The crystal structures revealed three- and two-dimensional hydrogen-bonding networks for the triclinic and orthorhombic polymorphs, respectively. The cations and anions are connected to one another via N-H···Cl and O-H···Cl interactions and form alternating cation-anion layer-like structures. The two polymorphs share common structural features; however, the conformations of the L-aspartate cations and the crystal packings are different. Furthermore, the molecular packing of the orthorhombic polymorph contains more interesting interactions which seems to be a favourable factor for more efficient charge transfer within the crystal.
authors.affiliation: Laboratoire des Structures, Propriétés et Interactions Interatomiques, Université Abbes Laghrour-Khenchela, 40000 Khenchela, Algeria.
authors.forename: Rim
authors.initials: R
authors.lastname: Benali-Cherif
authors.affiliation: Laboratoire des Structures, Propriétés et Interactions Interatomiques, Université Abbes Laghrour-Khenchela, 40000 Khenchela, Algeria.
authors.forename: Radhwane
authors.initials: R
authors.lastname: Takouachet
authors.affiliation: Université de Lorraine, CRM2, UMR 7036, Vandoeuvre-lès-Nancy, F-54506, France.
authors.forename: El-Eulmi
authors.initials: el-E
authors.lastname: Bendeif
authors.affiliation: Laboratoire des Structures, Propriétés et Interactions Interatomiques, Université Abbes Laghrour-Khenchela, 40000 Khenchela, Algeria.
authors.forename: Nourredine
authors.initials: N
authors.lastname: Benali-Cherif
mesh_terms: D000838:Anions / Q000737:chemistry*; D001224:Aspartic Acid / Q000737:chemistry*; D002412:Cations / Q000737:chemistry*; D003460:Crystallization; D006860:Hydrogen Bonding; D015394:Molecular Structure
chemical_list: D000838:Anions; D002412:Cations; D001224:Aspartic Acid
keywords: amino acids; crystal structure; hydrogen bonding; l-aspartic acid hydrochloride; pharmaceutical compounds; polymorphism