title: Weighted versus uniform dose of tranexamic acid in patients undergoing primary, elective knee arthroplasty: a prospective randomized controlled trial.
abstract: In a prospective, randomized, double-blinded, controlled study (25 controls), TA was infused parenterally before tourniquet release in two study groups. Group 1 (n = 20) received a 1 g dose, and group 2 (n = 20) received a 20 mg/kg dose. There was no significant difference between groups 1 and 2 with intra-operative, post-operative and total blood loss. Both groups 1 and 2 exhibited significant improvements in intra-operative, post-operative, and total blood loss compared to the control group (P < 0.05). Two blood transfusions were given to one patient in the weighted group, compared to 19 transfusions (10 patients) in the control group. This study suggests that a single 1-g dose can be used with the same efficacy as a weighted 20 mg/kg dose.
authors.affiliation: Rush University Medical Center, Chicago, Illinois.
authors.forename: Brett R
authors.initials: BR
authors.lastname: Levine
authors.affiliation: Rush University Medical Center, Chicago, Illinois.
authors.forename: Bryan D
authors.initials: BD
authors.lastname: Haughom
authors.affiliation: Rush University Medical Center, Chicago, Illinois.
authors.forename: Mark N
authors.initials: MN
authors.lastname: Belkin
authors.affiliation: Indiana University School of Medicine, Indianapolis, Indiana.
authors.forename: Zach H
authors.initials: ZH
authors.lastname: Goldstein
mesh_terms: D000328:Adult; D000368:Aged; D000933:Antifibrinolytic Agents / Q000008:administration & dosage*; D019645:Arthroplasty, Replacement, Knee / Q000379:methods*; D016063:Blood Loss, Surgical / Q000517:prevention & control; D001803:Blood Transfusion / Q000706:statistics & numerical data*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014148:Tranexamic Acid / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid
keywords: antifibrinolytics; blood loss; blood management; knee arthroplasty; tranexamic acid