title: WEB intrasaccular flow disruptor-prospective, multicenter experience in 83 patients with 85 aneurysms.
abstract: OBJECTIVE
  The safety and efficacy of WEB flow disruption have been analyzed in small, retrospective series. The object of this study was to evaluate the safety and efficacy of WEB flow disruption in a large, multicenter, prospectively collected population.
  
  
  METHODS
  Data from all patients treated with the WEB-DL device between June 2011 and October 2013 in 11 French neurointerventional centers were prospectively collected and retrospectively analyzed. Complications occurring during and after treatment were analyzed as well as morbidity and mortality at 1 month. Aneurysm occlusion status at the last follow-up was analyzed.
  
  
  RESULTS
  Eighty-three patients with 85 aneurysms were included in this series. Technical success was achieved in 77 patients with 79 aneurysms (92.9%). Periprocedural complications were observed in 9 patients (10.8%), leading to permanent neurologic deficits in 3 (3.9%). Morbidity and mortality at 1 month were 1.3% and 0.0%, respectively. Angiographic follow-up was performed for 65/79 aneurysms (82.3%) 3-24 months after treatment (mean, 5.3 months). Complete aneurysm occlusion was observed in 37/65 aneurysms (56.9%); neck remnant, in 23/65 (35.4%); and aneurysm remnant, in 5/65 (7.7%).
  
  
  CONCLUSIONS
  In this large prospective series of patients, WEB flow disruption was a safe and efficient technique.
authors.affiliation: From the Department of Neuroradiology (C.P., D.H.), Centre Hospitalier Universitaire (CHU) Tours, Tours, France.
authors.forename: C
authors.initials: C
authors.lastname: Papagiannaki
authors.affiliation: Department of Neuroradiology (L.S., J.M.), Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris, Clichy, France.
authors.forename: L
authors.initials: L
authors.lastname: Spelle
authors.affiliation: Department of Neuroradiology (A.-C.J., C.C.), CHU Toulouse, Toulouse, France.
authors.forename: A-C
authors.initials: AC
authors.lastname: Januel
authors.affiliation: Department of Neuroradiology (A.B., L.P.), CHU Reims, Reims, France.
authors.forename: A
authors.initials: A
authors.lastname: Benaissa
authors.affiliation: Department of Neuroradiology (J.-Y.G.), CHU Rennes, Rennes, France.
authors.forename: J-Y
authors.initials: JY
authors.lastname: Gauvrit
authors.affiliation: Department of Neuroradiology (V.C.), CHU Montpellier, Montpellier, France.
authors.forename: V
authors.initials: V
authors.lastname: Costalat
authors.affiliation: Department of Neuroradiology (H.D.), CHU Nantes, Nantes, France.
authors.forename: H
authors.initials: H
authors.lastname: Desal
authors.affiliation: Department of Neuroradiology (F.T.), CHU Lyon, Lyon France.
authors.forename: F
authors.initials: F
authors.lastname: Turjman
authors.affiliation: Department of Neuroradiology (S.V.), CHU Poitiers, Poitiers, France.
authors.forename: S
authors.initials: S
authors.lastname: Velasco
authors.affiliation: Department of Neuroradiology (X.B.), CHU Bordeaux, Bordeaux, France.
authors.forename: X
authors.initials: X
authors.lastname: Barreau
authors.affiliation: Department of Neuroradiology (P.C.), CHU Caen, Caen, France.
authors.forename: P
authors.initials: P
authors.lastname: Courtheoux
authors.affiliation: Department of Neuroradiology (A.-C.J., C.C.), CHU Toulouse, Toulouse, France.
authors.forename: C
authors.initials: C
authors.lastname: Cognard
authors.affiliation: From the Department of Neuroradiology (C.P., D.H.), Centre Hospitalier Universitaire (CHU) Tours, Tours, France.
authors.forename: D
authors.initials: D
authors.lastname: Herbreteau
authors.affiliation: Department of Neuroradiology (L.S., J.M.), Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris, Clichy, France.
authors.forename: J
authors.initials: J
authors.lastname: Moret
authors.affiliation: Department of Neuroradiology (A.B., L.P.), CHU Reims, Reims, France lpierot@gmail.com.
authors.forename: L
authors.initials: L
authors.lastname: Pierot
mesh_terms: D000328:Adult; D000368:Aged; D001807:Blood Vessel Prosthesis; D004621:Embolization, Therapeutic / Q000009:adverse effects / Q000295:instrumentation*; D057510:Endovascular Procedures / Q000009:adverse effects / Q000295:instrumentation*; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012189:Retrospective Studies; D016896:Treatment Outcome