title: Stereoselective synthesis of 3,7-diarylaminocholestanes by titanium-mediated reductive amination.
abstract: An efficient method for the synthesis of aryl aminocholestanes, using a chlorotriisopropoxytitanium(IV)-mediated reductive amination reaction of 5α-cholestane-3,7-dione, is reported. A series of 3,7-diarylaminocholestane derivatives were prepared according to this methodology in up to 98% yield. These compounds were primarily characterized by (1)H NMR, (13)C NMR, and mass spectrometry.
authors.affiliation: Department of Applied Chemistry, Kyungpook National University, Daegu 702-701, Republic of Korea.
authors.forename: Md Wasi
authors.initials: MW
authors.lastname: Ahmad
authors.affiliation: Department of Applied Chemistry, Kyungpook National University, Daegu 702-701, Republic of Korea. Electronic address: kimhs@knu.ac.kr.
authors.forename: Hong-Seok
authors.initials: HS
authors.lastname: Kim
mesh_terms: D000586:Amination; D002384:Catalysis; D002776:Cholestanes / Q000737:chemistry*; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D013379:Substrate Specificity; D014025:Titanium / Q000737:chemistry*
chemical_list: D002776:Cholestanes; D014025:Titanium
keywords: 3α,7α-Diarylaminocholestane; Chlorotriisopropoxytitanium(IV); Reductive amination; Stereoselective reaction