title: Chemotherapy-induced nausea and vomiting: optimizing prevention and management.
abstract: BACKGROUND
  Nausea and vomiting are serious side effects of cancer chemotherapy that can cause significant negative impacts on patients' quality of life and on their ability to tolerate and comply with therapy. Despite advances in the prevention and management of chemotherapy-induced nausea and vomiting (CINV), these side effects remain among the most distressing for patients.
  
  
  OBJECTIVE
  To discuss CINV and the current pharmacologic approaches to its management.
  
  
  CONCLUSIONS
  This article outlines the mechanism of CINV followed by a review of current approaches to pharmacologic therapy and current practice guidelines from national cancer organizations. This information will help providers and payers understand the optimal management of patients with CINV including practical considerations and value-based decision-making that considers cost issues.
  
  
  CONCLUSIONS
  Numerous preventive and treatment options are available to manage CINV Addressing antiemetic regimens requires ongoing patient evaluation to determine the best approach for each individual patient.
authors.affiliation: Oncology/BMT clinical pharmacist practitioner, University of North Carolina Hospitals and Clinics, Chapel Hill, NC.
authors.forename: Kamakshi V
authors.initials: KV
authors.lastname: Rao
authors.affiliation: Hematology/oncology clinical pharmacist practitioner, University of North Carolina Hospitals and Clinics, Chapel Hill, NC.
authors.forename: Aimee
authors.initials: A
authors.lastname: Faso