title: Facile synthetic method for diverse polyfunctionalized imidazoles by means of Pd-catalyzed C-H bond arylation of N-methyl-4,5-dibromoimidazole.
abstract: C-H bond-selective arylation reaction of 4,5-dibromoimidazole with aryl iodides, catalyzed by the palladium-1,10-phenanthroline complex [Pd(phen)2](PF6)2, has been developed. The process tolerates the presence of a variety of functional groups on the aryl halide substrates. The products formed in these reactions were transformed to a variety of polyfunctionalized imidazoles by taking advantage of selective reactions of remaining C-Br bonds.
authors.affiliation: Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University , Yanagido, Gifu 501-1193, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Yamauchi
authors.forename: Fumitoshi
authors.initials: F
authors.lastname: Shibahara
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Murai
mesh_terms: D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D006860:Hydrogen Bonding; D007093:Imidazoles / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D006846:Hydrocarbons, Halogenated; D007093:Imidazoles; C000595035:N-methyl-4,5-dibromoimidazole; D010165:Palladium