title: A general metal free approach to α-ketoamides via oxidative amidation-diketonization of terminal alkynes.
abstract: A novel catalytic system TMSOTf/I2/DMSO for the oxidative coupling of terminal alkynes with virtually any primary/secondary amine leading to α-ketoamides has been developed. The reaction possibly proceeds via iminium ion formation, wherein DMSO acts as a solvent as well as an oxidizing agent.
authors.affiliation: Academy of Scientific and Innovative Research (AcSIR), Natural Product Microbes, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, 180001, India. bashah@iiim.res.in.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Deshidi
authors.forename: Manjeet
authors.initials: M
authors.lastname: Kumar
authors.forename: Shekaraiah
authors.initials: S
authors.lastname: Devari
authors.forename: Bhahwal Ali
authors.initials: BA
authors.lastname: Shah
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D004121:Dimethyl Sulfoxide / Q000737:chemistry; D007455:Iodine / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D008698:Mesylates / Q000737:chemistry; D058451:Oxidative Coupling; D014297:Trimethylsilyl Compounds / Q000737:chemistry
chemical_list: D000480:Alkynes; D000577:Amides; D007659:Ketones; D008698:Mesylates; D014297:Trimethylsilyl Compounds; C053353:trimethylsilyl trifluoromethanesulfonate; D007455:Iodine; D004121:Dimethyl Sulfoxide