title: Oncoplastic breast conserving surgery with nipple-areolar preservation for centrally located breast cancer: a retrospective cohort study.
abstract: A compariosn was made of survival outcomes of oncoplastic breast conserving therapy (oBCT) with nipple- areolar (NAC) preservation in women with centrally located breast cancer (CLBC) undergoing modified radical mastectomy (MRM) in China in a matched retrospective cohort study. We used a database including patients who received oBCT (n=91) or MRM (n=182) from 2003 to 2013 in our hospital. Matching was conducted according to five variables: age at diagnosis, axillary lymph node status, hormone receptor status, human epidermal growth factor-like receptor 2 status (HER-2) and tumor stage. The match ratio was 1:2. Median follow-up times for the oBCT and MRM groups were 83 and 81 months, respectively. There were no significant differences in 87-month overall, local, or distant recurrence-free survival between patients with oBCT and MRM (89%vs.90%; 93%vs.95%; 91%vs.92%;). For appropriate breast cancer patients, oBCT for CLBC is oncologically safe, oncoplastic techniques improving cosmetic outcomes.
authors.affiliation: Department of Pathology, Jiangsu Cancer Hospital, Nanjing, China E-mail : renzhaojun18@126.com.
authors.forename: Zhao-Jun
authors.initials: ZJ
authors.lastname: Ren
authors.forename: Xiu-Juan
authors.initials: XJ
authors.lastname: Li
authors.forename: Xin-Yu
authors.initials: XY
authors.lastname: Xu
authors.forename: Lei
authors.initials: L
authors.lastname: Xia
authors.forename: Jin-Hai
authors.initials: JH
authors.lastname: Tang
mesh_terms: D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000401:mortality / Q000556:secondary / Q000601:surgery; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000401:mortality / Q000556:secondary / Q000601:surgery; D018275:Carcinoma, Lobular / Q000401:mortality / Q000556:secondary / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D016462:Mammaplasty; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D009367:Neoplasm Staging; D009558:Nipples / Q000473:pathology / Q000601:surgery*; D059351:Organ Sparing Treatments; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate