title: Tissue engineering in congenital diaphragmatic hernia.
abstract: Engineered diaphragmatic repair is emblematic of perinatal regenerative medicine and of the fetal tissue engineering concept. The alternative of a cellularized graft for the repair of a congenital diaphragmatic defect in the neonatal period is both biologically justifiable by the mechanisms behind diaphragmatic hernia recurrence as well as an ideal match for fetal mesenchymal stem cell-based constructs. It has been among the most developed experimental pursuits in neonatal tissue engineering, of which clinical application should be forthcoming.
authors.affiliation: Department of Surgery, Boston Children׳s Hospital, 300 Longwood Ave, Fegan 3, Boston, Massachusetts 02115; Department of Surgery, Harvard Medical School, Boston, Massachusetts. Electronic address: dario.fauza@childrens.harvard.edu.
authors.forename: Dario O
authors.initials: DO
authors.lastname: Fauza
mesh_terms: D003964:Diaphragm / Q000637:transplantation; D065630:Hernias, Diaphragmatic, Congenital / Q000601:surgery*; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods; D013710:Tendons / Q000637:transplantation; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds
keywords: Amniotic mesenchymal stem cells; Congenital anomalies; Congenital diaphragmatic hernia; Diaphragm; Diaphragmatic engineering; Fetal stem cells; Fetal tissue engineering; Tendon