title: Analysis of incidence and related factors of hemorrhagic fever with renal syndrome in Hebei Province, China.
abstract: BACKGROUND
  Hemorrhagic fever with renal syndrome (HFRS) is an important infectious disease in Hebei province, China. The average annual incidence is 3.10/100000. Although the incidence of HFRS is stable with a general decline in trend since 2004, an increase in the trend was observed in 2011. Few studies have been conducted to investigate the underlying risk factors for this disease.
  
  
  METHODS
  The epidemiological data of HFRS and the population data, meteorology, and remote sensing aspects of cities in Hebei province from 1999 to 2011 were collected. The epidemiological data included the population density in the region, seasonal data and rat density and rat's virus carriage rate. The data were analyzed by descriptive study, correlation analysis and multivariate linear analysis.
  
  
  RESULTS
  There were 26837 cases of HFRS was reported from 1999 to 2011. The infection occurred mainly in males, aged 20∼49 years, who were farmers. Rattus norvegicus was the main host animal. The incidence of HFRS was related to NDVI value, rat density and rat's virus carriage rate by multiple linear regression (F = 25.936, P<0.01). The pseudo- R2value for the model was 0.644.
  
  
  CONCLUSIONS
  The incidence of HFRS was related to NDVI value, rat density and rat's virus carriage rate. Control of these factors should be used to prevent HFRS in Hebei province.
authors.affiliation: Institute for Viral Disease Prevention and Control, Hebei Province Centre for Disease Prevention and Control, Shijiazhuang, Hebei Province, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Li
authors.affiliation: Institute for Viral Disease Prevention and Control, Hebei Province Centre for Disease Prevention and Control, Shijiazhuang, Hebei Province, China.
authors.forename: WenNa
authors.initials: W
authors.lastname: Zhao
authors.affiliation: Institute for Viral Disease Prevention and Control, Hebei Province Centre for Disease Prevention and Control, Shijiazhuang, Hebei Province, China.
authors.forename: YaMei
authors.initials: Y
authors.lastname: Wei
authors.affiliation: Institute for Viral Disease Prevention and Control, Hebei Province Centre for Disease Prevention and Control, Shijiazhuang, Hebei Province, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Han
authors.affiliation: Institute for Viral Disease Prevention and Control, Hebei Province Centre for Disease Prevention and Control, Shijiazhuang, Hebei Province, China.
authors.forename: ZhanYing
authors.initials: Z
authors.lastname: Han
authors.affiliation: Institute for Viral Disease Prevention and Control, Hebei Province Centre for Disease Prevention and Control, Shijiazhuang, Hebei Province, China.
authors.forename: YanBo
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Institute for Viral Disease Prevention and Control, Hebei Province Centre for Disease Prevention and Control, Shijiazhuang, Hebei Province, China.
authors.forename: ShunXiang
authors.initials: S
authors.lastname: Qi
authors.affiliation: Institute for Viral Disease Prevention and Control, Hebei Province Centre for Disease Prevention and Control, Shijiazhuang, Hebei Province, China.
authors.forename: YongGang
authors.initials: Y
authors.lastname: Xu
mesh_terms: D000328:Adult; D000818:Animals; D002681:China / Q000453:epidemiology; D004197:Disease Reservoirs / Q000821:virology; D005260:Female; D006480:Hemorrhagic Fever with Renal Syndrome / Q000453:epidemiology* / Q000821:virology; D006798:Housing; D006801:Humans; D015994:Incidence; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D051381:Rats; D055815:Young Adult