title: S2O8(2-)/UV-C and H2O2/UV-C treatment of Bisphenol A: assessment of toxicity, estrogenic activity, degradation products and results in real water.
abstract: The performance of S2O8(2-)/UV-C and H2O2/UV-C treatments was investigated for the degradation and detoxification of Bisphenol A (BPA). The acute toxicity of BPA and its degradation products was examined with the Vibrio fischeri bioassay, whereas changes in estrogenic activity were followed with the Yeast Estrogen Screen (YES) assay. LC and LC-MS/MS analyses were conducted to determine degradation products evolving during photochemical treatment. In addition, BPA-spiked real freshwater samples were also subjected to S2O8(2-)/UV-C and H2O2/UV-C treatment to study the effect of a real water matrix on BPA removal and detoxification rates. BPA removal in pure water was very fast (⩽7 min) and complete via both H2O2/UV-C and S2O8(2-)/UV-C treatment, accompanied with rapid and significant mineralization rates ranging between 70% and 85%. V.fischeri bioassay results indicated that degradation products being more toxic than BPA were formed at the initial stages of H2O2/UV-C whereas a rapid and steady reduction in toxicity was observed during S2O8(2-)/UV-C treatment in pure water. UV-C treatment products exhibited a higher estrogenic activity than the original BPA solution while the estrogenicity of BPA was completely removed during H2O2/UV-C and S2O8(2-)/UV-C treatments parallel to its degradation. 3-methylbenzoic and 4-sulfobenzoic acids, as well as the ring opening products fumaric, succinic and oxalic acids could be identified as degradation products. BPA degradation required extended treatment periods (>20 min) and TOC removals were considerably retarded (by 40%) in the raw freshwater matrix most probably due to its natural organic matter content (TOC=5.1 mg L(-1)). H2O2/UV-C and S2O8(2-)/UV-C treatment in raw freshwater did not result in toxic degradation products.
authors.affiliation: Istanbul Technical University, Civil Engineering Faculty, Environmental Engineering Department, 34469 Maslak, Istanbul, Turkey. Electronic address: tolmez@itu.edu.tr.
authors.forename: Tugba
authors.initials: T
authors.lastname: Olmez-Hanci
authors.affiliation: Istanbul Technical University, Civil Engineering Faculty, Environmental Engineering Department, 34469 Maslak, Istanbul, Turkey.
authors.forename: Duygu
authors.initials: D
authors.lastname: Dursun
authors.affiliation: Istanbul Technical University, Civil Engineering Faculty, Environmental Engineering Department, 34469 Maslak, Istanbul, Turkey.
authors.forename: Egemen
authors.initials: E
authors.lastname: Aydin
authors.affiliation: Istanbul Technical University, Civil Engineering Faculty, Environmental Engineering Department, 34469 Maslak, Istanbul, Turkey.
authors.forename: Idil
authors.initials: I
authors.lastname: Arslan-Alaton
authors.affiliation: Istanbul Technical University, Civil Engineering Faculty, Environmental Engineering Department, 34469 Maslak, Istanbul, Turkey.
authors.forename: Binhan
authors.initials: B
authors.lastname: Girit
authors.affiliation: I.N.B.B. - National Laboratory on Endocrine Disruptors, Via Pietro Castellino 111, 80131 Napoli, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Mita
authors.affiliation: I.N.B.B. - National Laboratory on Endocrine Disruptors, Via Pietro Castellino 111, 80131 Napoli, Italy; Seconda Università di Napoli, Department of Experimental Medicine, Via de Crecchio 7, 80138 Napoli, Italy.
authors.forename: Nadia
authors.initials: N
authors.lastname: Diano
authors.affiliation: I.N.B.B. - National Laboratory on Endocrine Disruptors, Via Pietro Castellino 111, 80131 Napoli, Italy.
authors.forename: Damiano G
authors.initials: DG
authors.lastname: Mita
authors.affiliation: I.N.B.B. - National Laboratory on Endocrine Disruptors, Via Pietro Castellino 111, 80131 Napoli, Italy; Università di Napoli Federico II, Department of Biology, Via Cinthia ed. 7, 80126 Napoli, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Guida
mesh_terms: D048908:Aliivibrio fischeri / Q000187:drug effects / Q000378:metabolism; D001559:Benzhydryl Compounds / Q000737:chemistry / Q000528:radiation effects / Q000633:toxicity; D002264:Carboxylic Acids / Q000737:chemistry; D002853:Chromatography, Liquid; D047628:Estrogen Receptor alpha / Q000378:metabolism; D004967:Estrogens / Q000737:chemistry / Q000528:radiation effects / Q000633:toxicity; D005618:Fresh Water; D006861:Hydrogen Peroxide / Q000737:chemistry*; D016877:Oxidants / Q000737:chemistry; D010636:Phenols / Q000737:chemistry / Q000528:radiation effects / Q000633:toxicity; D012441:Saccharomyces cerevisiae / Q000235:genetics; D017670:Sodium Compounds / Q000737:chemistry*; D013431:Sulfates / Q000737:chemistry*; D053719:Tandem Mass Spectrometry; D014466:Ultraviolet Rays; D014874:Water Pollutants, Chemical / Q000737:chemistry / Q000528:radiation effects / Q000633:toxicity; D018508:Water Purification / Q000379:methods; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D002264:Carboxylic Acids; D047628:Estrogen Receptor alpha; D004967:Estrogens; D006861:Hydrogen Peroxide; D016877:Oxidants; D010636:Phenols; D017670:Sodium Compounds; D013431:Sulfates; D014874:Water Pollutants, Chemical; C024625:sodium persulfate; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Acute toxicity; Bisphenol A; Degradation products; Real freshwater matrix; S(2)O(8)(2−)/UV-C and H(2)O(2)/UV-C treatments; Yeast Estrogen Screen (YES) assay