title: Dynamic CT perfusion imaging of the myocardium using a wide-detector scanner: a semiquantitative analysis in an animal model.
abstract: BACKGROUND
  Functional assessment of myocardial perfusion in computed tomography (CT) is a challenge.
  
  
  OBJECTIVE
  To evaluate CT dynamic myocardial perfusion imaging (MPI) using a wide-detector scanner.
  
  
  METHODS
  Time to peak (TTP), peak enhancement (PE), upslope (US), and the area under the curve (AUC) were calculated in 12 pigs (256-slice multidetector CT scanner).
  
  
  RESULTS
  The entire myocardium was covered by the scan volume. TTP was increased, and PE, US, and AUC were decreased in poststenotic myocardium.
  
  
  CONCLUSIONS
  CT MPI with complete coverage of the myocardium is feasible, providing evaluation of the physiological significance of coronary artery stenosis.
authors.affiliation: Department of Radiology, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Str. 22, 81675 München, Germany. Electronic address: muenzel@roe.med.tum.de.
authors.forename: Daniela
authors.initials: D
authors.lastname: Muenzel
authors.affiliation: Department of Radiology, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Str. 22, 81675 München, Germany.
authors.forename: Peter B
authors.initials: PB
authors.lastname: Noël
authors.affiliation: Department of Radiology, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Str. 22, 81675 München, Germany.
authors.forename: Bettina M
authors.initials: BM
authors.lastname: Gramer
authors.affiliation: Department of Radiology, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Str. 22, 81675 München, Germany.
authors.forename: Vivian
authors.initials: V
authors.lastname: Leber
authors.affiliation: MITI - Minimal-Invasive Interdisciplinary Therapeutic Intervention Research Group, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Str. 22, 81675 München, Germany.
authors.forename: Armin
authors.initials: A
authors.lastname: Schneider
authors.affiliation: Heart Center Munich, Klinikum Bogenhausen, Englschalkinger Strasse 77, 81925 München, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Leber
authors.affiliation: Philips Healthcare, CT Clinical Science, 595 Miner Road, Cleveland, OH 44143, USA.
authors.forename: Mani
authors.initials: M
authors.lastname: Vembar
authors.affiliation: Department of Radiology, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Str. 22, 81675 München, Germany.
authors.forename: Alexander A
authors.initials: AA
authors.lastname: Fingerle
authors.affiliation: Department of Radiology, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Str. 22, 81675 München, Germany.
authors.forename: Ernst J
authors.initials: EJ
authors.lastname: Rummeny
authors.affiliation: Department of Radiology, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Str. 22, 81675 München, Germany.
authors.forename: Armin
authors.initials: A
authors.lastname: Huber
mesh_terms: D000818:Animals; D003326:Coronary Circulation / Q000502:physiology*; D004867:Equipment Design; D005260:Female; D061330:Multidetector Computed Tomography / Q000295:instrumentation*; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging* / Q000503:physiopathology; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D015203:Reproducibility of Results; D013552:Swine
keywords: 256-Slice MDCT; Computed tomography; Coronary artery disease (CAD); Dynamic Myocardial perfusion; Ischemia