title: Spindle cell carcinoma of the breast as complex cystic lesion: a case report.
abstract: Spindle cell carcinoma of the breast is a rare tumor. This tumor can proliferate rapidly and cause cystic changes because of internal tissue necrosis. We evaluated a 54-year-old woman with right breast lump. Mammography showed a category four mass with a diameter of 2.5 cm. Ultrasonography (US) revealed a complex cystic lesion, and fine-needle aspiration (FNA) cytology demonstrated bloody fluid and malignant cells. Partial breast resection and sentinel lymph node biopsy were performed. Immunohistology revealed spindle cells with positive results for cytokeratin (AE1/AE3) and vimentin, partially positive results for s-100, and negative results for desmin and α-actin. The pathological stage was IIA, and biochemical characterization showed that the tumor was triple negative. Six courses of FEC-100 chemotherapy (5-fluorouracil 500 mg/m(2), epirubicin 100 mg/m(2), and cyclophosphamide 500 mg/m(2)) were administered. Radiotherapy was performed. This case is discussed with reference to the literature.
authors.affiliation: 1 Department of Surgery, 2 Department of Clinical Pathology, Asahikawa Medical University, Asahikawa Hokkaido 078-8510, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kitada
authors.affiliation: 1 Department of Surgery, 2 Department of Clinical Pathology, Asahikawa Medical University, Asahikawa Hokkaido 078-8510, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hayashi
authors.affiliation: 1 Department of Surgery, 2 Department of Clinical Pathology, Asahikawa Medical University, Asahikawa Hokkaido 078-8510, Japan.
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Matsuda
authors.affiliation: 1 Department of Surgery, 2 Department of Clinical Pathology, Asahikawa Medical University, Asahikawa Hokkaido 078-8510, Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Ishibashi
authors.affiliation: 1 Department of Surgery, 2 Department of Clinical Pathology, Asahikawa Medical University, Asahikawa Hokkaido 078-8510, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Oikawa
authors.affiliation: 1 Department of Surgery, 2 Department of Clinical Pathology, Asahikawa Medical University, Asahikawa Hokkaido 078-8510, Japan.
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Miyokawa
keywords: Breast cancer; cystic lesion; spindle cell carcinoma