title: Exploring the modulation of hypoxia-inducible factor (HIF)-1α by volatile anesthetics as a possible mechanism underlying volatile anesthetic-induced CNS injury.
abstract: This review summarizes recent research on the potential cognitive and behavioural abnormalities induced by exposure to volatile anesthetics and suggests a role of hypoxia-inducible factor (HIF)-1α in mediating these events. Volatile anesthetics are widely utilized in clinical and research settings, yet the long-term safety of exposure to these agents is under debate. Findings from various animal models suggest volatile anesthetics induce widespread apoptosis in the central nervous system (CNS) that correlates with lasting deficits in learning and memory. Longitudinal analysis of clinical data highlight an increased risk of developmental disorders later in life when children are exposed to volatile anesthetics, particularly when exposures occur over multiple sessions. However, the mechanisms underlying these events have yet to be established. Considering the extensive use of volatile anesthetics, it is crucial that these events are better understood. The possible role of HIF-1α in volatile anesthetic-induced CNS abnormalities will be suggested and areas requiring urgent attention will be outlined.
authors.affiliation: Division of Behavioural Neuroscience, Florey Institute of Neuroscience and Mental Health, University of Melbourne, L3, Kenneth Myer Building, Cnr Genetics Lane on Royal Parade, Parkville, VIC, 3010, Australia, emma.giles@florey.edu.au.
authors.forename: Emma K
authors.initials: EK
authors.lastname: Giles
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Lawrence
authors.forename: Jhodie R
authors.initials: JR
authors.lastname: Duncan
mesh_terms: D018685:Anesthetics, Inhalation / Q000009:adverse effects / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002490:Central Nervous System / Q000293:injuries*; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000187:drug effects*; D008137:Longitudinal Studies
chemical_list: D018685:Anesthetics, Inhalation; C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit