title: Formal [3+2] cycloaddition of 1-cyanocyclopropane 1-ester with pyridine, quinoline or isoquinoline: a general and efficient strategy for construction of cyanoindolizine skeletons.
abstract: An efficient and straightforward synthetic protocol has been developed for the preparation of cyanoindolizine derivatives via a cycloaddition reaction between 1-cyanocyclopropane 1-ester and pyridine or benzopyridine for the generation of a wide range of structurally interesting and pharmacologically significant compounds.
authors.affiliation: School of Chemistry and Chemical Engineering, Yangzhou University, 180 Siwangting Street, Yangzhou 225002, P. R. China. wangcd@yzu.edu.cn.
authors.forename: Juanjuan
authors.initials: J
authors.lastname: Liu
authors.forename: Lanxiang
authors.initials: L
authors.lastname: Zhou
authors.forename: Weijian
authors.initials: W
authors.lastname: Ye
authors.forename: Cunde
authors.initials: C
authors.lastname: Wang
mesh_terms: D061565:Cycloaddition Reaction; D003521:Cyclopropanes / Q000737:chemistry*; D004952:Esters; D054836:Indolizidines / Q000138:chemical synthesis*; D007546:Isoquinolines / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D011804:Quinolines / Q000737:chemistry*
chemical_list: D003521:Cyclopropanes; D004952:Esters; D054836:Indolizidines; D007546:Isoquinolines; D011725:Pyridines; D011804:Quinolines; C037219:quinoline; C039109:isoquinoline; C023666:pyridine