title: 123I-ioflupane SPECT findings of pantothenate kinase-associated neurodegeneration.
abstract: We present a case of a 72-year-old man with a 9-year history of memory decline and 7-year history of parkinsonian symptoms. An MRI demonstrated an "eye-of-the-tiger" sign in the basal ganglia, suggestive of pantothenate kinase-associated neurodegeneration (formerly known as Hallervorden-Spatz syndrome). An 123I-ioflupane SPECT scan demonstrated absence of radiotracer uptake in the caudate nuclei and putamina. Genetic testing confirmed a single-point mutation in the PANK2 gene, consistent with pantothenate kinase-associated neurodegeneration.
authors.affiliation: From the *Department of Radiology, University of Washington, and †Neuroimaging and Biotechnology Laboratory, Department of Radiology, University of Washington, Seattle, WA.
authors.forename: Arnold
authors.initials: A
authors.lastname: Kang
authors.forename: Satoshi
authors.initials: S
authors.lastname: Minoshima
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology; D002421:Caudate Nucleus / Q000000981:diagnostic imaging*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009662:Nortropanes; D006211:Pantothenate Kinase-Associated Neurodegeneration / Q000175:diagnosis / Q000000981:diagnostic imaging*; D011699:Putamen / Q000000981:diagnostic imaging*; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D009662:Nortropanes; D019275:Radiopharmaceuticals; C519528:ioflupane