title: Interactions between HIV-1 and the cell-autonomous innate immune system.
abstract: HIV-1 was recognized as the cause of AIDS in humans in 1984. Despite 30 years of intensive research, we are still unraveling the molecular details of the host-pathogen interactions that enable this virus to escape immune clearance and cause immunodeficiency. Here we explore a series of recent studies that consider how HIV-1 interacts with the cell-autonomous innate immune system as it navigates its way in and out of host cells. We discuss how these studies improve our knowledge of HIV-1 and host biology as well as increase our understanding of transmission, persistence, and immunodeficiency and the potential for therapeutic or prophylactic interventions.
authors.affiliation: Division of Infection and Immunity, University College London, London W1CE 6BT, UK. Electronic address: g.towers@ucl.ac.uk.
authors.forename: Greg J
authors.initials: GJ
authors.lastname: Towers
authors.affiliation: Division of Infection and Immunity, University College London, London W1CE 6BT, UK.
authors.forename: Mahdad
authors.initials: M
authors.lastname: Noursadeghi
mesh_terms: D015497:HIV-1 / Q000276:immunology*; D054884:Host-Pathogen Interactions; D006801:Humans; D057131:Immune Evasion; D007113:Immunity, Innate