title: The role of fetuin-A in cardiac functions and metabolism in peritoneal dialysis patients.
abstract: OBJECTIVE
  Fetuin-A is a member of protease inhibitors that act as an inhibitor of vascular calcification. In our study, the relationship of fetuin-A with metabolic and echocardiographic parameters in peritoneal dialysis (PD) patients has been investigated.
  
  
  METHODS
  Besides demographic, clinical and laboratory data, fetuin-A level was recorded. Echocardiographic examinations were performed by the same operator.
  
  
  RESULTS
  Fifty-two chronic PD patients (mean age: 52.7 ± 15.4 years) and 31 healthy volunteers (mean age: 41.3 ± 10.7 years) were included. Fetuin-A levels were significantly lower in the patient group (57.5 ± 31.5 ng/mL vs. 72.5 ± 34.0 ng/mL, P = 0.002). There was a significant relation between age and fetuin-A levels (P = 0.025). Four patients with chronic heart failure had significantly lower fetuin-A levels compared with those without. There was no relation between fetuin-A levels and the presence of diabetes mellitus, left ventricular hypertrophy and ischemic heart disease. No relationship was detected between fetuin-A level and any echocardiographic parameter. Age and hematocrite were correlated negatively, and serum albumin positively with fetuin-A levels. On linear regression analysis, fetuin-A level was related with age, hematocrite and presence of heart failure.
  
  
  CONCLUSIONS
  PD patients with heart failure have significantly lower fetuin-A levels. Age is a main determinant of fetuin-A level and fetuin-A may act as a negative acute phase reactant in PD patients.
authors.affiliation: Department of Nephrology, Haseki Training and Research Hospital, Istanbul, Turkey - meltem1401@yahoo.com.
authors.forename: Z
authors.initials: Z
authors.lastname: Aydin
authors.forename: S
authors.initials: S
authors.lastname: Ozturk
authors.forename: C
authors.initials: C
authors.lastname: Celik
authors.forename: M
authors.initials: M
authors.lastname: Gursu
authors.forename: S
authors.initials: S
authors.lastname: Karadag
authors.forename: M
authors.initials: M
authors.lastname: Yamak
authors.forename: F
authors.initials: F
authors.lastname: Basinoglu
authors.forename: A
authors.initials: A
authors.lastname: Gurdal
authors.forename: A
authors.initials: A
authors.lastname: Sumnu
authors.forename: E
authors.initials: E
authors.lastname: Cebeci
authors.forename: E
authors.initials: E
authors.lastname: Sakci
authors.forename: F
authors.initials: F
authors.lastname: Sar
authors.forename: R
authors.initials: R
authors.lastname: Kazancioğlu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D004452:Echocardiography; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006334:Heart Function Tests; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D010530:Peritoneal Dialysis; D051436:Renal Insufficiency, Chronic / Q000000981:diagnostic imaging / Q000235:genetics / Q000628:therapy; D055815:Young Adult; D060749:alpha-2-HS-Glycoprotein / Q000235:genetics* / Q000378:metabolism
chemical_list: C556354:AHSG protein, human; D060749:alpha-2-HS-Glycoprotein