title: Radionuclide imaging for breast cancer diagnosis and management: is technetium-99m tetrofosmin uptake related to the grade of malignancy?
abstract: There are different scoring systems available for determining the grade of breast cancer malignancy. Breast cancer tumors have been described for grades 1-3 using the modified Nottingham-Bloom-Richardson grading system. Determining the grade is very important for the clinicians to choose the best treatment options. Technetium-99m methoxy isobutyl isonitrile ((99m)Tc-MIBI) and pentavalent (99m)Tc-dimercaptosuccinic acid ((99m)Tc(V)-DMSA) scintigraphy have been used and are under evaluation for being prognostic factors for breast carcinoma. Radionuclide breast imaging not only visualizes the lesion site but also reflects specific biological and functional lesion features, including perfusion, proliferative potential, metabolic activity and receptor status.
authors.affiliation: Department of Nuclear Medicine, Kayseri Training and Research Hospital Department of Nuclear Medicine, 38010 Kayseri, Turkey. gulersilov@yahoo.com.
authors.forename: Güler
authors.initials: G
authors.lastname: Silov
authors.forename: Arzu
authors.initials: A
authors.lastname: Taşdemir
authors.forename: Ayşegül
authors.initials: A
authors.lastname: Ozdal
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Erdoğan
authors.forename: Esma Mehtap
authors.initials: EM
authors.lastname: Başbuğ
authors.forename: Ayşe Esra
authors.initials: AE
authors.lastname: Arslan
authors.forename: Ozgül
authors.initials: O
authors.lastname: Turhal
mesh_terms: D001692:Biological Transport; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D008327:Mammography; D060787:Neoplasm Grading; D009943:Organophosphorus Compounds / Q000378:metabolism*; D015609:Organotechnetium Compounds / Q000378:metabolism*; D011877:Radionuclide Imaging
chemical_list: D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; C078700:technetium tc-99m tetrofosmin