title: Evaluation of a predictive model for pancreatic fistula based on amylase value in drains after pancreatic resection.
abstract: BACKGROUND
  Amylase value in drains (AVD) is a predictor of pancreatic fistula (PF). We evaluated the accuracy of an AVD-based model.
  
  
  METHODS
  Two hundred thirty-one patients underwent pancreatoduodenectomy with pancreaticojejunostomy (PDPJ) or pancreatoduodenectomy with duct-to-mucosa (PDDTM) and distal pancreatectomy (DP). Patients with AVD greater than 5,000 U/L on postoperative day (POD) 1 underwent AVD measurement on POD5.
  
  
  RESULTS
  Sensitivity and specificity of POD1 AVD greater than 5,000 in predicting PF were 71% and 90%, respectively. The sensitivity and specificity of POD5 AVD greater than 200 were 90% and 83%, respectively. AVD greater than 1,000 (for PDPJ) and 2,000 U/L (PDDTM and DP) represented the most accurate cutoffs on POD1. AVD greater than 200 (PDPJ), 300 (PDDTM), and 50 U/L (DP) represented the cutoffs with the highest sensitivity in predicting PF on POD5.
  
  
  CONCLUSIONS
  AVD-based model for predicting PF after pancreatic resection is an accurate tool, although AVD cutoffs should be evaluated for each type of operation.
authors.affiliation: Department of Surgery, Ospedale Sacro Cuore Don Calabria, Negrar, Verona, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Partelli
authors.affiliation: Department of Surgery, Ospedale Sacro Cuore Don Calabria, Negrar, Verona, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Tamburrino
authors.affiliation: Department of Surgery, Ospedale Sacro Cuore Don Calabria, Negrar, Verona, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Crippa
authors.affiliation: Department of Surgery, Ospedale Sacro Cuore Don Calabria, Negrar, Verona, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Facci
authors.affiliation: Department of Surgery, Ospedale Sacro Cuore Don Calabria, Negrar, Verona, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Zardini
authors.affiliation: Department of Surgery, Ospedale Sacro Cuore Don Calabria, Negrar, Verona, Italy. Electronic address: m.falconi@univpm.it.
authors.forename: Massimo
authors.initials: M
authors.lastname: Falconi
mesh_terms: D000368:Aged; D000681:Amylases / Q000378:metabolism*; D004322:Drainage / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy / Q000009:adverse effects*; D010185:Pancreatic Fistula / Q000175:diagnosis* / Q000201:enzymology* / Q000453:epidemiology; D010190:Pancreatic Neoplasms / Q000601:surgery*; D016577:Pancreaticoduodenectomy / Q000009:adverse effects; D010193:Pancreaticojejunostomy / Q000009:adverse effects; D011183:Postoperative Complications; D011237:Predictive Value of Tests; D012372:ROC Curve; D012086:Reoperation; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors
chemical_list: D000681:Amylases
keywords: Amylase; Drain; Pancreatic fistula; Surgery