title: Telomere shortening in leukocyte subpopulations in depression.
abstract: BACKGROUND
  Telomere shortening is a normal age-related process. However, premature shortening of telomeres in leukocytes--as has been reported in depression--may increase the risk for age-related diseases. While previous studies investigated telomere length in peripheral blood mononuclear cells (PBMCs) as a whole, this study investigated specific changes in the clonal composition of white blood cells of the adaptive immune system (CD4+ helper and CD8+ cytotoxic T lymphocytes, and CD20+ B lymphocytes).
  
  
  METHODS
  Forty-four females with a history of unipolar depression were investigated and compared to fifty age-matched female controls. Telomere lengths were compared between three groups: 1) individuals with a history of depression but currently no clinically relevant depressive symptoms, 2) individuals with a history of depression with relevant symptoms of depression, and 3) healthy age-matched controls. Telomere length was assessed using quantitative fluorescence in situ hybridization (qFISH).
  
  
  RESULTS
  Both groups with a history of unipolar depression (with and without current depressive symptoms) showed significantly shorter telomeres in all three lymphocyte subpopulations. The effect was stronger in CD8+ and CD20+ cells than in CD4+ cells. Individuals with a history of depression and with (without) current symptoms exhibited a CD8+ telomere length shortening corresponding to an age differential of 27.9 (25.3) years.
  
  
  CONCLUSIONS
  A history of depression is associated with shortened telomeres in the main effector populations of the adaptive immune system. Shorter telomeres seem to persist in individuals with lifetime depression independently of the severity of depressive symptoms. CD8+ cytotoxic T cells and CD20+ B cells seem to be particularly affected in depression. The total number of depressive episodes did not influence telomere length in the investigated adaptive immune cell populations.
authors.affiliation: Clinical & Biological Psychology, Institute of Psychology and Education, University of Ulm, Ulm, Germany. alexander.karabatsiakis@uni-ulm.de.
authors.forename: Alexander
authors.initials: A
authors.lastname: Karabatsiakis
authors.forename: Iris-Tatjana
authors.initials: IT
authors.lastname: Kolassa
authors.forename: Stephan
authors.initials: S
authors.lastname: Kolassa
authors.forename: K Lenhard
authors.initials: KL
authors.lastname: Rudolph
authors.forename: Detlef E
authors.initials: DE
authors.lastname: Dietrich
mesh_terms: D000328:Adult; D018414:CD8-Positive T-Lymphocytes; D003866:Depressive Disorder / Q000235:genetics*; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007962:Leukocytes; D007963:Leukocytes, Mononuclear; D012306:Risk; D016615:Telomere / Q000235:genetics*; D059506:Telomere Shortening