title: Dimorphic changes of some features of loving relationships during long-term use of antidepressants in depressed outpatients.
abstract: The present study aimed at investigating the possible changes of some features of loving relationships during long-term treatment of depression with both selective serotonin reuptake inhibitors (SSRIs) and tricyclics (TCAs), by means of a specifically designed test, the so-called "Sex, Attachment, Love" (SALT) questionnaire. The sample was composed by 192 outpatients (123 women and 69 men, mean age±SD: 41.2±10.2 years), suffering from mild or moderate depression, according to DSM-IV-TR criteria, that were selected if they were treated with one antidepressant only for at least six months and were involved in a loving relationship. The results showed that SSRIs had a significant impact on the feelings of love and attachment towards the partner especially in men, while women taking TCAs complained of more sexual side effects than men. These data were supported also by the detection of a significant interaction between drug and sex on the "Love" and "Sex" domains. The present findings, while demonstrating a dimorphic effect of antidepressants on some component of loving relationships, need to be deepened in future studies.
authors.affiliation: Dipartimento di Medicina Clinica e Sperimentale, University of Pisa, Italy. Electronic address: dmarazzi@psico.med.unipi.it.
authors.forename: Donatella
authors.initials: D
authors.lastname: Marazziti
authors.affiliation: Dipartimento di Medicina Clinica e Sperimentale, University of Pisa, Italy; International Mood Center, San Diego Veterans Administration Medical Center, San Diego, CA, USA.
authors.forename: Hagop S
authors.initials: HS
authors.lastname: Akiskal
authors.affiliation: International Mood Center, San Diego Veterans Administration Medical Center, San Diego, CA, USA.
authors.forename: Mieko
authors.initials: M
authors.lastname: Udo
authors.affiliation: Dipartimento di Medicina Clinica e Sperimentale, University of Pisa, Italy.
authors.forename: Michela
authors.initials: M
authors.lastname: Picchetti
authors.affiliation: Dipartimento di Medicina Clinica e Sperimentale, University of Pisa, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Baroni
authors.affiliation: Dipartimento di Medicina Clinica e Sperimentale, University of Pisa, Italy.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Massimetti
authors.affiliation: Dipartimento di Medicina Clinica e Sperimentale, University of Pisa, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Albanese
authors.affiliation: Dipartimento di Medicina Clinica e Sperimentale, University of Pisa, Italy.
authors.forename: Liliana
authors.initials: L
authors.lastname: Dell'Osso
mesh_terms: D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage* / Q000009:adverse effects*; D003075:Coitus; D003863:Depression / Q000188:drug therapy* / Q000453:epidemiology / Q000523:psychology; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004334:Drug Administration Schedule; D005191:Family Characteristics; D005260:Female; D020010:Heterosexuality / Q000523:psychology; D006716:Homosexuality / Q000523:psychology; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008149:Love; D008297:Male; D008875:Middle Aged; D009769:Object Attachment; D010045:Outpatients; D057566:Self Report; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects*; D012720:Severity of Illness Index; D012737:Sex Factors
chemical_list: D000929:Antidepressive Agents, Tricyclic; D017367:Selective Serotonin Reuptake Inhibitors
keywords: Antidepressants; Depression; Emotional blunting; Gender; Romantic relationships; Side effects