title: Association between polymorphism of TGFA Taq I and cleft lip and/or palate: a meta-analysis.
abstract: BACKGROUND
  Cleft lip and palate (CL/P) is one of the most common malformations in humans. Transforming growth factor alpha (TGFA) is a well characterized mammalian growth factor which might contribute to the development of CL/P. This meta-analysis aimed to summarize the association between the TGFA Taq I polymorphisms and CL/P.
  
  
  METHODS
  We retrieved the relevant articles from PubMed, EMBASE, ISI Web of Science and SCOPUS databases. Studies were selected using specific inclusion and exclusion criteria. The odds ratios (ORs) and their 95% confidence intervals (95% CIs) were calculated to assess the association between TGFA Taq I polymorphism and CL/P risk. Meta-analyses were performed on the total data set and separately for the major ethnic groups, disease type and source of control. All analyses were performed using the Stata software.
  
  
  RESULTS
  Twenty articles were included in the present analysis. There is a significant association between the TGFA Taq I polymorphism and CL/P (C1C2 vs C1C1: OR = 1.67, 95% CI = 1.23-2.25, C2C2 + C1C2 vs C1C1C1: OR = 1.52, 95% CI = 1.15-2.01; C2 vs C1:OR = 1.41, 95% CI = 1.12-1.78). Stratified analyses suggested that the TGFA Taq I polymorphism was significantly associated with CL/P in Caucasians (C1C2 vs C1C1: OR = 1.95, 95% CI = 1.34-2.86; C2C2 + C1C2 vs C1C1: OR = 1.68, 95% CI = 1.18-2.38; C2 vs V1: OR = 1.52, 95% CI = 1.14 -2.02).
  
  
  CONCLUSIONS
  TGFA Taq I polymorphism may be associated with the risk of CL/P.
authors.affiliation: Department of Orthodontics, School of Stomatology, China Medical University, No,117 North Nanjing Street, Shenyang 110002, PR China. fcjxll@outlook.com.
authors.forename: Cuijuan
authors.initials: C
authors.lastname: Feng
authors.forename: Enjiao
authors.initials: E
authors.lastname: Zhang
authors.forename: Weiyi
authors.initials: W
authors.lastname: Duan
authors.forename: Zhongfei
authors.initials: Z
authors.lastname: Xu
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Lu
mesh_terms: D000483:Alleles; D002874:Chromosome Mapping; D002971:Cleft Lip / Q000235:genetics*; D002972:Cleft Palate / Q000235:genetics*; D017353:Gene Deletion; D005799:Genes, Dominant / Q000235:genetics; D005808:Genes, Recessive / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D016211:Transforming Growth Factor alpha / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: C587886:TGFA protein, human; D016211:Transforming Growth Factor alpha