title: Effects of adaptive statistical iterative reconstruction on radiation dose reduction and diagnostic accuracy of pediatric abdominal CT.
abstract: BACKGROUND
  Since children are more radio-sensitive than adults, there is a need to minimize radiation exposure during CT exams.
  
  
  OBJECTIVE
  To evaluate the effects of adaptive statistical iterative reconstruction (ASIR) on radiation dose reduction, image quality and diagnostic accuracy in pediatric abdominal CT.
  
  
  METHODS
  We retrospectively reviewed the abdominal CT examinations of 41 children (24 boys and 17 girls; mean age: 10 years) with a low-dose radiation protocol and reconstructed with ASIR (the ASIR group). We also reviewed routine-dose abdominal CT examinations of 41 age- and sex-matched controls reconstructed with filtered-back projection (control group). Image quality was assessed objectively as noise measured in the liver, spleen and aorta, as well as subjectively by three pediatric radiologists for diagnostic acceptability using a four-point scale. Radiation dose and objective image qualities of each group were compared with the paired t-test. Diagnostic accuracy was evaluated by reviewing follow-up imaging studies and medical records in 2012 and 2013.
  
  
  RESULTS
  There was 46.3% dose reduction of size-specific dose estimates in ASIR group (from 13.4 to 7.2 mGy) compared with the control group. Objective noise was higher in the liver, spleen and aorta of the ASIR group (P < 0.001). However, the subjective image quality was average or superior in 84-100% of studies. Only one image was subjectively rated as unacceptable by one reviewer. There was only one case with interpretational error in the control group and none in the ASIR group.
  
  
  CONCLUSIONS
  Use of the ASIR technique resulted in greater than a 45% reduction in radiation dose without impairing subjective image quality or diagnostic accuracy in pediatric abdominal CT, despite increased objective image noise.
authors.affiliation: Department of Radiology and Research Institute of Radiological Science, Severance Children's Hospital, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, 120-752, Seoul, South Korea.
authors.forename: Sohi
authors.initials: S
authors.lastname: Bae
authors.forename: Myung-Joon
authors.initials: MJ
authors.lastname: Kim
authors.forename: Choon-Sik
authors.initials: CS
authors.lastname: Yoon
authors.forename: Dong Wook
authors.initials: DW
authors.lastname: Kim
authors.forename: Jung Hwa
authors.initials: JH
authors.lastname: Hong
authors.forename: Mi-Jung
authors.initials: MJ
authors.lastname: Lee
mesh_terms: D000008:Abdominal Neoplasms / Q000000981:diagnostic imaging*; D001699:Biometry / Q000379:methods*; D002648:Child; D005260:Female; D005767:Gastrointestinal Diseases / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D010372:Pediatrics / Q000379:methods / Q000706:statistics & numerical data; D011829:Radiation Dosage; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods; D011860:Radiography, Abdominal / Q000379:methods* / Q000706:statistics & numerical data; D015203:Reproducibility of Results; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods* / Q000706:statistics & numerical data