title: The prevalence of prediabetes in population of Polish men with late-onset hypogonadism.
abstract: OBJECTIVE
  Prediabetes patients are likely to develop type 2 diabetes (T2DM). Low testosterone is a risk factor for impaired glucose tolerance (IGT) in men. The aim of this study was to investigate the prevalence of prediabetes in population of Polish men with late-onset hypogonadism (LOH).
  
  
  METHODS
  This study was performed in 246 men with LOH and in 184 eugonadal control group. Prediabetes was diagnosed in patients with impaired fasting glucose (IFG), IGT or with HbA1c from 5.7 to 6.4%. Sex hormones and metabolic parameters were measured.
  
  
  RESULTS
  The mean TT concentration in the LOH group was 9.55 ± 1.5 nmol/l and 16.45 ± 1.8 nmol/l in the control group (p < 0.001). We observed negative relationships between cFT and HbA1c (r = -0.336; p < 0.005) and between TT and HbA1c (r = -0.366, p < 0.002), In the LOH group, prediabetes was diagnosed in 41.5% men. In the control group, prediabetes was diagnosed in 13% of patients. In the LOH group, TT and cFT levels were lower in prediabetic patients, when compared with normoglycemic patients and patients with IGT had lower TT levels than subgroups with IFG or elevated HbA1c.
  
  
  CONCLUSIONS
  In a population of Polish men with LOH, we observed high prevalence of prediabetes and routine fasting glucose and glucose tolerance test should be performed in these patients.
authors.affiliation: Department of Internal Diseases, Diabetology and Endocrinology, Warsaw Medical University , Warsaw , Poland and.
authors.forename: Michał
authors.initials: M
authors.lastname: Rabijewski
authors.forename: Lucyna
authors.initials: L
authors.lastname: Papierska
authors.forename: Paweł
authors.initials: P
authors.lastname: Piątkiewicz
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2; D005058:Eunuchism / Q000150:complications*; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011044:Poland / Q000453:epidemiology; D011236:Prediabetic State / Q000453:epidemiology* / Q000209:etiology; D015995:Prevalence; D013739:Testosterone / Q000097:blood
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D013739:Testosterone; C517652:hemoglobin A1c protein, human
keywords: Aging male; prediabetes; testestosterone