title: Prognostic factors for regression from impaired glucose tolerance to normal glucose regulation in Japanese patients with nonalcoholic fatty liver disease.
abstract: OBJECTIVE
  The aim of this retrospective cohort study was to assess the predictive factors for the regression from impaired glucose tolerance (IGT) to normal glucose regulation (NGR) in patients with nonalcoholic fatty liver disease (NAFLD).
  
  
  METHODS
  A total of 164 NAFLD patients who had IGT in the first 75-g oral glucose tolerance test (OGTT) and underwent a repeated OGTT five years later were enrolled. A multivariate logistic regression analysis was carried out to identify factors predicting the regression from IGT to NGR.
  
  
  RESULTS
  Out of the 164 patients, 29 regressed from IGT to NGR within five years after the first OGTT. The multivariate analysis by logistic regression showed that regression from IGT to NGR occurred when the patient was young (risk ratio for ten years: 0.38; 95% confidence interval [CI] 0.20-0.72; p=0.003), had a fasting plasma glucose (FPG) level of <100 mg/dL (risk ratio: 6.53; 95%CI 1.88-21.73; p=0.003), had a 2-hr post-load plasma glucose (PG) level of <160 mg/dL (risk ratio: 4.86; 95%CI 1.08-22.72; p=0.040), a body mass index (BMI) decrease of ≥1.5 (risk ratio: 5.20; 95% CI 1.41-19.24; p=0.014), physical activity of ≥2 Metabolic Equivalent of Task (MET) h/day (risk ratio: 5.57; 95%CI 1.68-18.44; p=0.005), and showed disappearance of the fatty liver by ultrasonography at five years (risk ratio: 9.92; 95%CI 2.87-34.34; p<0.001).
  
  
  CONCLUSIONS
  Our results suggest that six factors: young age, FPG <100 mg/dL, 2-hr post-load PG of <160 mg/dL, BMI decrease of ≥1.5, physical activity of ≥2 MET h/day, and the disappearance of fatty liver predict the regression from IGT to NGR in NAFLD patients.
authors.affiliation: Department of Health Management Center, Toranomon Hospital, Japan.
authors.forename: Chie
authors.initials: C
authors.lastname: Ogata
authors.forename: Yuki
authors.initials: Y
authors.lastname: Ohmoto-Sekine
authors.forename: Maho
authors.initials: M
authors.lastname: Tanabe
authors.forename: Akiko
authors.initials: A
authors.lastname: Iwao
authors.forename: Shiun Dong
authors.initials: SD
authors.lastname: Hsieh
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Amakawa
authors.forename: Naoki
authors.initials: N
authors.lastname: Matsumoto
authors.forename: Kyoko
authors.initials: K
authors.lastname: Ogawa
authors.forename: Satao
authors.initials: S
authors.lastname: Arimoto
authors.forename: Chikao
authors.initials: C
authors.lastname: Okuda
authors.forename: Masato
authors.initials: M
authors.lastname: Shiba
authors.forename: Hisahito
authors.initials: H
authors.lastname: Kato
authors.forename: Mitsue
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Makiko
authors.initials: M
authors.lastname: Ishihara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tsuji
authors.forename: Shigeko
authors.initials: S
authors.lastname: Hara
authors.forename: Yasuji
authors.initials: Y
authors.lastname: Arase
mesh_terms: D000367:Age Factors; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D005234:Fatty Liver / Q000097:blood; D005260:Female; D018149:Glucose Intolerance / Q000097:blood*; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood*; D016017:Odds Ratio; D012189:Retrospective Studies
chemical_list: D001786:Blood Glucose; D007328:Insulin