title: Endomyocardial fibrosis (EMF) in a Ugandan child with advanced hepatosplenic schistosomiasis: coincidence or connection?
abstract: An association between late-stage hepatosplenic schistosomiasis and endomyocardial fibrosis (EMF) has been suggested but not proven. We present the case of a 12-year-old Ugandan boy with striking comorbidities, including advanced periportal fibrosis caused by Schistosoma mansoni infection and right ventricular EMF, and discuss the possible correlation between both diseases.
authors.affiliation: Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom; Department of Pediatrics, Guy's and St. Thomas's National Health Service (NHS) Trust, London, United Kingdom; Department of Internal Medicine, Mulago Hospital, Kampala, Uganda; Department of Radiology, Mulago Hospital, Kampala, Uganda; Hospital for Tropical Diseases, Mortimer Market Centre, London, United Kingdom; Department of Infection, Guy's and St. Thomas's NHS Trust, London, United Kingdom Amaya.Bustinduy@liverpool.ac.uk.
authors.forename: Amaya L
authors.initials: AL
authors.lastname: Bustinduy
authors.affiliation: Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom; Department of Pediatrics, Guy's and St. Thomas's National Health Service (NHS) Trust, London, United Kingdom; Department of Internal Medicine, Mulago Hospital, Kampala, Uganda; Department of Radiology, Mulago Hospital, Kampala, Uganda; Hospital for Tropical Diseases, Mortimer Market Centre, London, United Kingdom; Department of Infection, Guy's and St. Thomas's NHS Trust, London, United Kingdom.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Luzinda
authors.affiliation: Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom; Department of Pediatrics, Guy's and St. Thomas's National Health Service (NHS) Trust, London, United Kingdom; Department of Internal Medicine, Mulago Hospital, Kampala, Uganda; Department of Radiology, Mulago Hospital, Kampala, Uganda; Hospital for Tropical Diseases, Mortimer Market Centre, London, United Kingdom; Department of Infection, Guy's and St. Thomas's NHS Trust, London, United Kingdom.
authors.forename: Simon
authors.initials: S
authors.lastname: Mpoya
authors.affiliation: Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom; Department of Pediatrics, Guy's and St. Thomas's National Health Service (NHS) Trust, London, United Kingdom; Department of Internal Medicine, Mulago Hospital, Kampala, Uganda; Department of Radiology, Mulago Hospital, Kampala, Uganda; Hospital for Tropical Diseases, Mortimer Market Centre, London, United Kingdom; Department of Infection, Guy's and St. Thomas's NHS Trust, London, United Kingdom.
authors.forename: Philip
authors.initials: P
authors.lastname: Gothard
authors.affiliation: Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom; Department of Pediatrics, Guy's and St. Thomas's National Health Service (NHS) Trust, London, United Kingdom; Department of Internal Medicine, Mulago Hospital, Kampala, Uganda; Department of Radiology, Mulago Hospital, Kampala, Uganda; Hospital for Tropical Diseases, Mortimer Market Centre, London, United Kingdom; Department of Infection, Guy's and St. Thomas's NHS Trust, London, United Kingdom.
authors.forename: Neil
authors.initials: N
authors.lastname: Stone
authors.affiliation: Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom; Department of Pediatrics, Guy's and St. Thomas's National Health Service (NHS) Trust, London, United Kingdom; Department of Internal Medicine, Mulago Hospital, Kampala, Uganda; Department of Radiology, Mulago Hospital, Kampala, Uganda; Hospital for Tropical Diseases, Mortimer Market Centre, London, United Kingdom; Department of Infection, Guy's and St. Thomas's NHS Trust, London, United Kingdom.
authors.forename: Stephen
authors.initials: S
authors.lastname: Wright
authors.affiliation: Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom; Department of Pediatrics, Guy's and St. Thomas's National Health Service (NHS) Trust, London, United Kingdom; Department of Internal Medicine, Mulago Hospital, Kampala, Uganda; Department of Radiology, Mulago Hospital, Kampala, Uganda; Hospital for Tropical Diseases, Mortimer Market Centre, London, United Kingdom; Department of Infection, Guy's and St. Thomas's NHS Trust, London, United Kingdom.
authors.forename: J Russell
authors.initials: JR
authors.lastname: Stothard
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use; D002648:Child; D004719:Endomyocardial Fibrosis / Q000150:complications* / Q000188:drug therapy / Q000469:parasitology; D005243:Feces / Q000469:parasitology; D006801:Humans; D008107:Liver Diseases / Q000150:complications* / Q000188:drug therapy / Q000469:parasitology; D008297:Male; D011223:Praziquantel / Q000627:therapeutic use; D011433:Propranolol / Q000627:therapeutic use; D012550:Schistosoma mansoni / Q000302:isolation & purification*; D012555:Schistosomiasis mansoni / Q000150:complications* / Q000188:drug therapy / Q000469:parasitology; D013158:Splenic Diseases / Q000150:complications* / Q000188:drug therapy / Q000469:parasitology; D014454:Uganda; D014665:Vasodilator Agents / Q000627:therapeutic use
chemical_list: D000871:Anthelmintics; D014665:Vasodilator Agents; D011223:Praziquantel; D011433:Propranolol