title: Ischemia/reperfusion of unilateral kidney exaggerates aging-induced damage to the heart and contralateral kidney.
abstract: OBJECTIVE
  We aimed to determine the impact of aging on ischemic acute kidney injury, especially in terms of the pathological mechanisms of kidney and heart crosstalk.
  
  
  METHODS
  The effects of 45 min of unilateral ischemic reperfusion (IR) of the renal artery on the contralateral kidney and heart were histologically assessed in 7- and 40-week-old SD rats after 7 days.
  
  
  RESULTS
  Glomerular sclerosis, interstitial fibrosis and numbers of ED1 cells were significantly increased in the contralateral kidneys of the 40-, but not the 7-week-old rats. The numbers of ED1 cells in the heart significantly and similarly increased in both groups, but reactive fibrosis after IR was significant only in the 40-week-old rats. The exaggerated profibrotic response induced by aging seemed to be closely associated with the increased number of ED1 cells in the affected area.
  
  
  CONCLUSIONS
  Aging could play a major role in exaggerating the pathological processes of inflammation to fibrosis in remote organs including the heart and the nonischemic kidney after IR stimulation of the unilateral kidney.
authors.affiliation: Research Division of CKD and Dialysis, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Junichiro
authors.initials: J
authors.lastname: Kato
authors.forename: Masaaki
authors.initials: M
authors.lastname: Nakayama
authors.forename: Wan-Jun
authors.initials: WJ
authors.lastname: Zhu
authors.forename: Takashi
authors.initials: T
authors.lastname: Yokoo
authors.forename: Sadayoshi
authors.initials: S
authors.lastname: Ito
mesh_terms: D058186:Acute Kidney Injury / Q000378:metabolism / Q000473:pathology*; D000375:Aging / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D005355:Fibrosis; D006331:Heart Diseases / Q000378:metabolism / Q000473:pathology*; D007668:Kidney / Q000378:metabolism / Q000473:pathology*; D008297:Male; D051381:Rats; D020303:Rats, Inbred Dahl; D015427:Reperfusion Injury / Q000378:metabolism / Q000473:pathology*