title: Can we identify risk factors during pregnancy for thrombo-embolic events during the puerperium and later in life?
abstract: OBJECTIVE
  To investigate parturients at risk to develop venous thrombo-embolic events (VTE) in the puerperium or later in life, during a follow-up of more than a decade and compare risk factors for VTE during the puerperium with VTE later in life.
  
  
  METHODS
  A nested case-control study was conducted to profile parturients at risk for VTE and a secondary analysis to compare risk factors for VTE during or after puerperium. We used a cohort of 95 257 women who gave birth between the years 1988 and 1998.
  
  
  RESULTS
  Independent risk factors to develop VTE were peripartum hysterectomy, stillbirth, cesarean delivery (CD), obesity, pregnancy-related hypertension, grandmultiparity and advanced maternal age. Women undergoing CD and those receiving blood transfusion were more likely to develop early versus late VTE (OR = 2.0, 95% CI = 1.15-3.5 and OR = 11.0, 95% CI = 2.25-55.5; respectively). Patients that encountered VTE during the puerperium had more pulmonary emboli and less deep vein thrombosis, compared with the late VTE group (p < 0.001).
  
  
  CONCLUSIONS
  Maternal age, grandmultiparity, pregnancy-related hypertension, CD, obesity, stillbirth and peripartum hysterectomy are independent risk factors for the development of VTE. CD and blood transfusion were predictive of early versus late VTE.
authors.affiliation: Department of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev , Beer-Sheva , Israel and.
authors.forename: Maor
authors.initials: M
authors.lastname: Waldman
authors.forename: Eyal
authors.initials: E
authors.lastname: Sheiner
authors.forename: Ruslan
authors.initials: R
authors.lastname: Sergienko
authors.forename: Ilana
authors.initials: I
authors.lastname: Shoham-Vardi
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007557:Israel / Q000453:epidemiology; D049590:Postpartum Period; D011247:Pregnancy; D012044:Regression Analysis; D012307:Risk Factors; D054556:Venous Thromboembolism / Q000453:epidemiology*; D055815:Young Adult
keywords: Pregnancy; puerperium; risk factors; thrombo-embolic events