title: Screening of the genital human papillomavirus infection among 8581 women in the First Affiliated Hospital of Xi'an Jiaotong University.
abstract: OBJECTIVE
  To investigate the prevalence of genital human papillomavirus (HPV) infection among women in Shaan'xi Province of China, and to detect the characteristics of genital HPV infection among these women.
  
  
  METHODS
  Totally 8581 women in the Department of Gynaecology of the First Affiliated Hospital of Xi'an Jiaotong University were enrolled to detect HPV-DNA in their genital tracts by PCR+flow-through hybridization. Some subjects were also screened by cytology or histology.
  
  
  RESULTS
  Among these subjects, the prevalence of female genital tract HPV infection was 33.06%, among which high risk (HR)-HPV infection accounted for 30.08% and multiple HR-HPV infection 27.18%. The genotypes HPV-16, -52,-58, -6, and HPV-18 were the most prevalent strains. The distribution of HPV infection differed among different age groups:the first infection peak occured less than 25 years and the second peak was above 51 years. Among the HR-HPV DNA positive women, the rates of HR-HPV infection with normal histology, cervical intraepithelial neoplasias 1 (CIN1), CIN2 ,CIN3, and cervical cancer (CC) were 88.72%, 97.48%, 97.35%, 95.88%, and 99.23%, respectively. For women with CC, HPV-16 was the most common genotype, followed by HPV-18, HPV-58, HPV-52, and HPV-33. HPV-16 ,-18, and 58 were responsible for 94.62% of CC cases in this region.
  
  
  CONCLUSIONS
  The most common genotypes of HPV infection among women in Shaan'xi province are HPV-16, HPV-52, HPV-58, HPV-6, and HPV-18. HPV-16, HPV-18, HPV-58, HPV-52, and HPV-33 are the most frequently genotypes found in cervical carcinoma, in particular HPV-16, HPV-18, and HPV-58. HR-HPV infection aggravates the cervical lesions. The multiple HPV infections increase the risk of cervical lesions.
authors.affiliation: Department of Obstetrics and Gynecology,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Ma
authors.affiliation: Department of Obstetrics and Gynecology,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China.
authors.forename: Meng
authors.initials: M
authors.lastname: Hou
authors.affiliation: Department of Obstetrics and Gynecology,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China.
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002681:China / Q000453:epidemiology; D004279:DNA, Viral / Q000302:isolation & purification; D005260:Female; D005838:Genotype; D006801:Humans; D008403:Mass Screening; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000453:epidemiology*; D015995:Prevalence; D060737:Reproductive Tract Infections / Q000453:epidemiology* / Q000821:virology; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology / Q000821:virology
chemical_list: D004279:DNA, Viral