title: Treatment for avascular necrosis of bone in people with sickle cell disease.
abstract: BACKGROUND
  Avascular necrosis of bone is a frequent and severe complication of sickle cell disease and its treatment is not standardised.
  
  
  OBJECTIVE
  To determine the impact of any surgical procedure compared with other surgical interventions or non-surgical procedures, on avascular necrosis of bone in people with sickle cell disease in terms of efficacy and safety.
  
  
  METHODS
  We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Haemoglobinopathies Trials Register, comprising references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books of conference proceedings. Additional trials were sought from the reference lists of papers identified by the search strategy.Date of the most recent search of the Group's Haemoglobinopathies Trials Register: 17 March 2014.
  
  
  METHODS
  Randomised clinical trials comparing specific therapies for avascular necrosis of bone in people with sickle cell disease.
  
  
  METHODS
  Each author independently extracted data and assessed trial quality. Since only one trial was identified, meta-analysis was not possible.
  
  
  RESULTS
  One trial (46 participants) was eligible for inclusion. After randomisation eight participants were withdrawn, mainly because they declined to participate in the trial. Data were analysed for 38 participants at the end of the trial. After a mean follow up of three years, hip core decompression and physical therapy did not show clinical improvement when compared with physical therapy alone using the score from the original trial (an improvement of 18.1 points for those treated with intervention therapy versus an improvement of 15.7 points with control therapy). There was no significant statistical difference between groups regarding major complications (hip pain, relative risk (RR) 0.95 (95% confidence interval (CI) 0.56 to 1.60; vaso-occlusive crises, RR 1.14 (95% CI 0.72 to 1.80; very low quality of evidence); and acute chest syndrome, RR 1.06 (95% CI 0.44 to 2.56; very low quality of evidence)). This trial did not report results on mortality or quality of life.
  
  
  CONCLUSIONS
  We found no evidence that adding hip core decompression to physical therapy achieves clinical improvement in people with sickle cell disease with avascular necrosis of bone compared to physical therapy alone. However, we highlight that our conclusion is based on one trial with high attrition rates. Further randomised controlled trials are necessary to evaluate the role of hip-core depression for this clinical condition. Endpoints should focus on participants' subjective experience (e.g. quality of life and pain) as well as more objective 'time-to-event' measures (e.g. mortality, survival, hip longevity). The availability of participants to allow adequate trial power will be a key consideration for endpoint choice.
authors.affiliation: Iberoamerican Cochrane Network, Valencia, Venezuela.
authors.forename: Arturo J
authors.initials: AJ
authors.lastname: Martí-Carvajal
authors.forename: Ivan
authors.initials: I
authors.lastname: Solà
authors.forename: Luis H
authors.initials: LH
authors.lastname: Agreda-Pérez
mesh_terms: D000755:Anemia, Sickle Cell / Q000150:complications*; D019299:Decompression, Surgical / Q000379:methods*; D006621:Hip Joint / Q000601:surgery; D006801:Humans; D010020:Osteonecrosis / Q000209:etiology / Q000628:therapy*; D026741:Physical Therapy Modalities; D016032:Randomized Controlled Trials as Topic