title: Oncological and functional outcome after surgical treatment of early glottic carcinoma without anterior commissure involvement.
abstract: BACKGROUND
  Glottic carcinoma can be successfully diagnosed in its early stages and treated with high percentage of success. Organ preservation and optimal functional outcomes could be achieved with wide array of surgical techniques for early glottic cancer, including endoscopic approaches or open laryngeal preserving procedures, making surgery the preferred method of treatment of early glottic carcinoma in the last few years.
  
  
  METHODS
  Prospective study was done on 59 patients treated for Tis and T1a glottic carcinoma over a one-year time period in a tertiary medical center. Patients were treated with endoscopic laser cordectomy (types II-IV cordectomies according to European Laryngological Society classification of endoscopic cordectomies) and open cordectomy through laryngofissure. Follow-up period was 60 months. Clinical and oncological results were followed postoperatively. Voice quality after the treatment was assessed using multidimensional voice analysis 12 months after the treatment.
  
  
  RESULTS
  There were no significant differences between oncological and functional results among two groups of patients, though complications were more frequent in patients treated with open cordectomy.
  
  
  CONCLUSIONS
  Endoscopic laser surgery should be the first treatment of choice in treatment of early glottic carcinomas, though open approach through laryngofissure should be available for selected cases where anatomical factors present limiting adequate tumor removal.
authors.affiliation: Medical Faculty Belgrade, University of Belgrade, Belgrade, Serbia ; Clinic for Otorhinolaryngology and Maxillofacial Surgery, Clinical Centre of Serbia, Pasterova 2, Belgrade, Serbia.
authors.forename: Jovica
authors.initials: J
authors.lastname: Milovanovic
authors.affiliation: Medical Faculty Belgrade, University of Belgrade, Belgrade, Serbia ; Clinic for Otorhinolaryngology and Maxillofacial Surgery, Clinical Centre of Serbia, Pasterova 2, Belgrade, Serbia.
authors.forename: Ana
authors.initials: A
authors.lastname: Jotic
authors.affiliation: Medical Faculty Belgrade, University of Belgrade, Belgrade, Serbia ; Clinic for Otorhinolaryngology and Maxillofacial Surgery, Clinical Centre of Serbia, Pasterova 2, Belgrade, Serbia.
authors.forename: Vojko
authors.initials: V
authors.lastname: Djukic
authors.affiliation: Medical Faculty Belgrade, University of Belgrade, Belgrade, Serbia ; Clinic for Otorhinolaryngology and Maxillofacial Surgery, Clinical Centre of Serbia, Pasterova 2, Belgrade, Serbia.
authors.forename: Bojan
authors.initials: B
authors.lastname: Pavlovic
authors.affiliation: Medical Faculty Belgrade, University of Belgrade, Belgrade, Serbia ; Clinic for Otorhinolaryngology and Maxillofacial Surgery, Clinical Centre of Serbia, Pasterova 2, Belgrade, Serbia.
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Trivic
authors.affiliation: Medical Faculty Belgrade, University of Belgrade, Belgrade, Serbia ; Clinic for Otorhinolaryngology and Maxillofacial Surgery, Clinical Centre of Serbia, Pasterova 2, Belgrade, Serbia.
authors.forename: Sanja
authors.initials: S
authors.lastname: Krejovic-Trivic
authors.affiliation: Medical Faculty Belgrade, University of Belgrade, Belgrade, Serbia ; Clinic for Medical Rehabilitation, Clinical Center of Serbia, Belgrade, Serbia.
authors.forename: Andjela
authors.initials: A
authors.lastname: Milovanovic
authors.affiliation: Medical Faculty Belgrade, University of Belgrade, Belgrade, Serbia ; Institute for Occupational Health of Serbia "Dr Dragomir Karajovic," Belgrade, Serbia.
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Milovanovic
authors.affiliation: Medical Faculty Belgrade, University of Belgrade, Belgrade, Serbia ; Institute for Nuclear Medicine, Clinical Centre of Serbia, Belgrade, Serbia.
authors.forename: Vera
authors.initials: V
authors.lastname: Artiko
authors.affiliation: Center for Radiology and Magnetic Resonance Imaging, Clinical Center of Serbia, Belgrade, Serbia.
authors.forename: Bojan
authors.initials: B
authors.lastname: Banko
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery*; D004724:Endoscopy; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000601:surgery*; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011446:Prospective Studies; D016896:Treatment Outcome; D014827:Vocal Cords / Q000473:pathology* / Q000601:surgery; D014831:Voice / Q000502:physiology