title: Using population isolates in genetic association studies.
abstract: The use of genetically isolated populations can empower next-generation association studies. In this review, we discuss the advantages of this approach and review study design and analytical considerations of genetic association studies focusing on isolates. We cite successful examples of using population isolates in association studies and outline potential ways forward.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Hatzikotoulas
authors.forename: Arthur
authors.initials: A
authors.lastname: Gilly
authors.forename: Eleftheria
authors.initials: E
authors.lastname: Zeggini
mesh_terms: D000818:Animals; D056726:Genetic Association Studies / Q000379:methods*; D014644:Genetic Variation / Q000235:genetics; D055106:Genome-Wide Association Study / Q000379:methods; D006801:Humans
keywords: complex disease; genetic association studies; isolated populations; rare variants