title: Glutathione S-transferase Omega 2 Genetic Polymorphism and Risk of Hepatic Failure that Lead to Liver Transplantation in Iranian Population.
abstract: BACKGROUND
  Liver transplantation is the treatment of choice for both acute and chronic hepatic failure. GSTs family is one of the most important genes in phase II detoxification interfering with the xenobiotics and free radical metabolism. GSTO2 (N142D) is a member of this family the polymorphism of which may influence the metabolism of active components and free radicals and may contribute to hepatic failure.
  
  
  OBJECTIVE
  To investigate the association between GSTO2 genetic polymorphism and the susceptibility of hepatic failure that would lead to liver transplantation.
  
  
  METHODS
  This case-control study included 330 healthy people and 302 patients with liver transplantation as a result of hepatic failure. To determine the variants of GSTO2, we used polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.
  
  
  RESULTS
  There was a significant association between D allele and hepatic failure, thus, people with DD genotype are more susceptible to develop heaptic failure leading to liver transplantation (OR=1.8, 95% CI: 1.10-2.95, p=0.02). We also observed that male sex increases the chance of hepatic failure (OR=2.69, 95% CI: 1.95-3.71, p=0.001).
  
  
  CONCLUSIONS
  D allele may reduce the detoxification ability of liver so people with mutant D allele are more prone to develop hepatic failure.
authors.affiliation: Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Khosravi
authors.affiliation: Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran ; Institute of Biotechnology, Shiraz University, Shiraz, Iran.
authors.forename: I
authors.initials: I
authors.lastname: Saadat
authors.affiliation: Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: M H
authors.initials: MH
authors.lastname: Karimi
authors.affiliation: Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: B
authors.initials: B
authors.lastname: Geramizadeh
authors.affiliation: Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran ; Institute of Biotechnology, Shiraz University, Shiraz, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Saadat
keywords: Glutathione S-transferase; Hepatic failure; Liver transplantation