title: [Biological role of Interleukin 33 and its importance in pathophysiology of cardiovascular system].
abstract: Interleukin 33 (IL-33) is a member of the IL-1 cytokin family. It is expressed by various cells and tissues, mainly epithelial and endothelial cells. It is a cytokine with dual function. It may act both as a traditional cytokine and as intracellular nuclear factor, functioning as transcription regulator. Its biological effect via interaction with membrane-bound ST2 receptor and IL-1 receptor accessory protein (IL-1RAcP) is associated with the induction of Th2-type immune response and IL-5 and IL-13 synthesis. IL-33 has a strong immunoregulatory properties. Depending on the type of activated cells, microenvironment, and costimulatory factors, IL-33 can act either as a pro- or anti-inflammatory cytokine. Recent studies indicate various protective effect of IL-33/ST2 sygnaling in atherosclerosis, obesity, disorders in glucose homeostasis and in heart diseases. The paper presents current state of knowledge about the structure and biological function of IL-33 and its receptor ST2, with particular emphasis on its role in pathophysiology of cardiovascular system.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Czyzewska-Buczyńska
authors.forename: Natalia
authors.initials: N
authors.lastname: Zuk
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Romanowska-Micherda
authors.forename: Wojciech
authors.initials: W
authors.lastname: Witkiewicz
mesh_terms: D000273:Adipose Tissue / Q000276:immunology / Q000378:metabolism; D000818:Animals; D050197:Atherosclerosis / Q000276:immunology; D009202:Cardiomyopathies / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism; D042783:Endothelial Cells / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism; D006801:Humans; D000072179:Interleukin-1 Receptor-Like 1 Protein; D018793:Interleukin-13 / Q000096:biosynthesis*; D000067596:Interleukin-33; D015848:Interleukin-5 / Q000096:biosynthesis*; D007378:Interleukins / Q000276:immunology / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000276:immunology / Q000378:metabolism; D017472:Receptors, Interleukin-1 / Q000378:metabolism
chemical_list: C079241:IL1RL1 protein, human; C506536:IL33 protein, human; D000072179:Interleukin-1 Receptor-Like 1 Protein; D018793:Interleukin-13; D000067596:Interleukin-33; D015848:Interleukin-5; D007378:Interleukins; D011956:Receptors, Cell Surface; D017472:Receptors, Interleukin-1