title: Trier social stress test in Indian adolescents.
abstract: OBJECTIVE
  To test the Trier Social Stress Test for children (TSST-C) in a cohort of Indian adolescents.
  
  
  METHODS
  Cohort study.
  
  
  METHODS
  Holdsworth Memorial Hospital, Mysore, India.
  
  
  METHODS
  Adolescent children (N=273, 134 males; mean age 13.6 yrs) selected from an ongoing birth cohort; 269 completed the test.
  
  
  METHODS
  Performance of 5-minutes each of public- speaking and mental arithmetic tasks in front of two unfamiliar 'evaluators'.
  
  
  METHODS
  Salivary cortisol concentrations were measured at baseline and at regular intervals after the TSST-C. Continuous measurements of heart rate, finger blood pressure, stroke volume, cardiac output and systemic vascular resistance were carried out before, during and for 10 minutes after the TSST-C using a finger cuff.
  
  
  RESULTS
  Cortisol concentrations [mean increment (SD): 6.1 (6.9) ng/mL], heart rate [4.6 (10.1) bpm], systolic [24.2 (11.6) mmHg] and diastolic blood pressure [16.5 (7.3) mmHg], cardiac output [0.6 (0.7) L/min], stroke volume [4.0 (5.6) mL] and systemic vascular resistance [225 (282) dyn.s/cm5] increased significantly (P<0.001) from baseline after inducing stress.
  
  
  CONCLUSIONS
  The TSST-C produces stress responses in Indian adolescents of a sufficient magnitude to be a useful tool for examining stress physiology and its relationships to disease outcomes in this population.
authors.affiliation: Epidemiology Research Unit, CSI Holdsworth Memorial Hospital, Mysore, India; *Centre for Cardiovascular Imaging, UCL Institute of Child Health, London, UK; Diabetes Unit, KEM Hospital Research Centre, Pune, India;Department of Psychology, University of Trier, Germany; St. Johns Research Institute, Bangalore, India; and MRC Lifecourse Epidemiology Unit, Southampton General Hospital, Southampton, UK. Correspondence to: Dr GV Krishnaveni, Epidemiology Research Unit, CSI Holdsworth Memorial Hospital, PO Box 38, Mandi Mohalla, Mysore 570 021, India. gv.krishnaveni@gmail.com.
authors.forename: G V
authors.initials: GV
authors.lastname: Krishnaveni
authors.forename: S R
authors.initials: SR
authors.lastname: Veena
authors.forename: A
authors.initials: A
authors.lastname: Jones
authors.forename: D S
authors.initials: DS
authors.lastname: Bhat
authors.forename: M P
authors.initials: MP
authors.lastname: Malathi
authors.forename: D
authors.initials: D
authors.lastname: Hellhammer
authors.forename: K
authors.initials: K
authors.lastname: Srinivasan
authors.forename: H
authors.initials: H
authors.lastname: Upadya
authors.forename: A V
authors.initials: AV
authors.lastname: Kurpad
authors.forename: C H D
authors.initials: CH
authors.lastname: Fall
mesh_terms: D000293:Adolescent; D015331:Cohort Studies; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis; D007194:India / Q000453:epidemiology; D008297:Male; D011581:Psychological Tests; D012463:Saliva / Q000737:chemistry; D013315:Stress, Psychological / Q000453:epidemiology* / Q000503:physiopathology*
chemical_list: D006854:Hydrocortisone