title: Risk factors for eosinophilic esophagitis.
abstract: Eosinophilic esophagitis (EoE) is a chronic antigen driven disease, whereby food and/or aeroallergens result in inflammation and luminal narrowing, and the clinical symptoms of dysphagia and food bolus obstruction events (FBOE). Established risk factors are male gender, Caucasian race and atopy. Increased risk amongst family members, and a single nucleotide polymorphism (SNP) in a gene coding thymic stromal lymphopoietin (TSLP) on the pseudoautosomal region of the X and Y chromosomes supports a genetic predisposition. Environmental factors including the timing and nature of food and aeroallergen exposure to the developing immune system may be important, whilst esophageal barrier function integrity and the influence of microbiota are worthy of future research.
authors.affiliation: Department of Gastroenterology, Box Hill Hospital, Melbourne, Victoria, Australia; Department of Gastroenterology, The Alfred Hospital, Melbourne, Victoria, Australia.
authors.forename: H
authors.initials: H
authors.lastname: Philpott
authors.forename: S
authors.initials: S
authors.lastname: Nandurkar
authors.forename: S G
authors.initials: SG
authors.lastname: Royce
authors.forename: F
authors.initials: F
authors.lastname: Thien
authors.forename: P R
authors.initials: PR
authors.lastname: Gibson
mesh_terms: D000367:Age Factors; D000485:Allergens / Q000276:immunology; D057765:Eosinophilic Esophagitis / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D005502:Food / Q000009:adverse effects; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D064307:Microbiota; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D000485:Allergens
keywords: allergy; antigen; eosinophil; esophagus; remodelling