title: Current advances in polymer-based nanotheranostics for cancer treatment and diagnosis.
abstract: Nanotheranostics is a relatively new, fast-growing field that combines the advantages of treatment and diagnosis via a single nanoscale carrier. The ability to bundle both therapeutic and diagnostic capabilities into one package offers exciting prospects for the development of novel nanomedicine. Nanotheranostics can deliver treatment while simultaneously monitoring therapy response in real-time, thereby decreasing the potential of over- or under-dosing patients. Polymer-based nanomaterials, in particular, have been used extensively as carriers for both therapeutic and bioimaging agents and thus hold great promise for the construction of multifunctional theranostic formulations. Herein, we review recent advances in polymer-based systems for nanotheranostics, with a particular focus on their applications in cancer research. We summarize the use of polymer nanomaterials for drug delivery, gene delivery, and photodynamic therapy, combined with imaging agents for magnetic resonance imaging, radionuclide imaging, and fluorescence imaging.
authors.affiliation: Department of NanoEngineering and Moores Cancer Center, University of California , San Diego, La Jolla, California 92093, United States.
authors.forename: Brian T
authors.initials: BT
authors.lastname: Luk
authors.forename: Liangfang
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D004337:Drug Carriers; D008279:Magnetic Resonance Imaging; D051379:Mice; D036103:Nanotechnology; D009369:Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D011108:Polymers / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D011108:Polymers
keywords: cancer; drug delivery; imaging; nanoparticle; polymer; theranostics