title: Vascular Complications After Radiotherapy in Head and Neck Free Flap Reconstruction: Clinical Outcome Related to Vascular Biology.
abstract: Radiotherapy as a risk factor for free flap failure has been widely debated. The purpose of this study was to investigate vascular complications in free flap surgery at a center advocating preoperative radiotherapy. On the basis of previous experimental studies, we also aimed to investigate temporal aspects of vascular complications in both arteries and veins. Furthermore, we aimed to study the effect of tissue plasminogen activator (tPA), because irradiated microvascular recipient vessels are associated with impaired fibrinolysis.A retrospective review was conducted for 344 consecutive head and neck microvascular reconstructions. Radiotherapy was administered previously in 283 (82%) of the cases, median dose 64 Gy. Flap outcome, vascular complications, and salvage attempts were identified, along with time elapsed from completed radiotherapy, described as early (<6 weeks), delayed (6-15 weeks) and late (>15 weeks) reconstructions.Total flap loss was more common in irradiated cases (P = 0.035), among which flap failure increased with time elapsed from the last radiotherapy session to surgery (P = 0.021). Among 30 registered vascular complications, venous thrombosis was the most common type and increased in delayed, compared to early, reconstructions (P = 0.012). Increased salvage rates were observed when tPA was administered intraoperatively (P = 0.015).The present study indicates that previous radiotherapy is a risk factor for head and neck free flap failure, especially in delayed reconstructions. This may be linked to previous findings of impaired fibrinolysis in irradiated microvascular recipient veins, which is further supported by the beneficial effect of tPA during salvage surgery. We emphasize the importance of early reconstruction after radiotherapy and suggest that there is a role for fibrinolytic agents during free flap salvage surgery in previously irradiated subjects.
authors.affiliation: From the *Department of Surgery, Norrtälje Hospital; Departments of †Molecular Medicine and Surgery, Section of Reconstructive Plastic Surgery and ‡Medicine, Center for Molecular Medicine, Karolinska Institutet; and §Department of Reconstructive Plastic Surgery, Karolinska University Hospital, Stockholm Sweden.
authors.forename: Jael
authors.initials: J
authors.lastname: Tall
authors.forename: Tinna Christersdottir
authors.initials: TC
authors.lastname: Björklund
authors.forename: Ann-Charlott Docherty
authors.initials: AC
authors.lastname: Skogh
authors.forename: Claes
authors.initials: C
authors.lastname: Arnander
authors.forename: Martin
authors.initials: M
authors.lastname: Halle
mesh_terms: D000328:Adult; D000368:Aged; D001158:Arteries; D005260:Female; D058752:Free Tissue Flaps / Q000098:blood supply* / Q000637:transplantation; D006085:Graft Survival; D006258:Head and Neck Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D011183:Postoperative Complications / Q000175:diagnosis / Q000209:etiology*; D018714:Radiotherapy, Adjuvant; D019651:Plastic Surgery Procedures / Q000379:methods; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D014680:Veins; D020246:Venous Thrombosis / Q000175:diagnosis / Q000209:etiology*