title: The "angiogenetic ladder", step-wise angiogenesis inhibition in metastatic colorectal cancer.
abstract: The number of anti-angiogenic drugs who demonstrated activity in metastatic colorectal cancer patients is arising but there is still much debate on which is the optimal use of this class of agents, with particular emphasis given on when (meant as in which line of treatment) and how (meant as in duration of treatment). We sampled the data of randomised phase II-III trials employing this type of drugs, with particular emphasis on trying to "highlight" situations where anti-angiogenetic treatment could provide most benefit. The review displays all relevant clinical data regarding the use of anti-angiogenic drugs in metastatic colorectal cancer and comments on potential implications of these trials in everyday clinical practice.
authors.affiliation: Department of Clinical Oncology, Translational Oncology Unit, Università Politecnica delle Marche, AOU "Ospedali Riuniti", Via Conca 71, 60020 Ancona, Italy. Electronic address: kakeru@libero.it.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Giampieri
authors.affiliation: Department of Clinical Oncology, Translational Oncology Unit, Università Politecnica delle Marche, AOU "Ospedali Riuniti", Via Conca 71, 60020 Ancona, Italy. Electronic address: marioscartozzi@gmail.com.
authors.forename: Mario
authors.initials: M
authors.lastname: Scartozzi
authors.affiliation: Department of Clinical Oncology, Translational Oncology Unit, Università Politecnica delle Marche, AOU "Ospedali Riuniti", Via Conca 71, 60020 Ancona, Italy. Electronic address: micheladelprete@gmail.com.
authors.forename: Michela
authors.initials: M
authors.lastname: Del Prete
authors.affiliation: Department of Clinical Oncology, Translational Oncology Unit, Università Politecnica delle Marche, AOU "Ospedali Riuniti", Via Conca 71, 60020 Ancona, Italy. Electronic address: agnese.fulli@libero.it.
authors.forename: Agnese
authors.initials: A
authors.lastname: Fulli
authors.affiliation: Department of Clinical Oncology, Translational Oncology Unit, Università Politecnica delle Marche, AOU "Ospedali Riuniti", Via Conca 71, 60020 Ancona, Italy. Electronic address: lucafaloppi@gmail.com.
authors.forename: Luca
authors.initials: L
authors.lastname: Faloppi
authors.affiliation: Department of Clinical Oncology, Translational Oncology Unit, Università Politecnica delle Marche, AOU "Ospedali Riuniti", Via Conca 71, 60020 Ancona, Italy. Electronic address: stellabianconi@gmail.com.
authors.forename: Maristella
authors.initials: M
authors.lastname: Bianconi
authors.affiliation: Department of Clinical Oncology, Translational Oncology Unit, Università Politecnica delle Marche, AOU "Ospedali Riuniti", Via Conca 71, 60020 Ancona, Italy. Electronic address: elena.maccaroni@live.it.
authors.forename: Elena
authors.initials: E
authors.lastname: Maccaroni
authors.affiliation: Department of Clinical Oncology, Translational Oncology Unit, Università Politecnica delle Marche, AOU "Ospedali Riuniti", Via Conca 71, 60020 Ancona, Italy. Electronic address: cascinu@yahoo.com.
authors.forename: Stefano
authors.initials: S
authors.lastname: Cascinu
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D017322:Clinical Trials, Phase II as Topic; D017326:Clinical Trials, Phase III as Topic; D015179:Colorectal Neoplasms / Q000098:blood supply* / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D009362:Neoplasm Metastasis; D009389:Neovascularization, Pathologic / Q000188:drug therapy; D016032:Randomized Controlled Trials as Topic
chemical_list: D020533:Angiogenesis Inhibitors
keywords: Angiogenesis; Bevacizumab; Colon cancer