title: The evolution of enzyme function in the isomerases.
abstract: The advent of computational approaches to measure functional similarity between enzymes adds a new dimension to existing evolutionary studies based on sequence and structure. This paper reviews research efforts aiming to understand the evolution of enzyme function in superfamilies, presenting a novel strategy to provide an overview of the evolution of enzymes belonging to an individual EC class, using the isomerases as an exemplar.
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, United Kingdom. Electronic address: scuesta@ebi.ac.uk.
authors.forename: Sergio
authors.initials: S
authors.lastname: Martinez Cuesta
authors.affiliation: Department of Pathogen Molecular Biology, London School of Hygiene & Tropical Medicine, Keppel Street, London, WC1E 7HT, United Kingdom.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Furnham
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, United Kingdom.
authors.forename: Syed Asad
authors.initials: SA
authors.lastname: Rahman
authors.affiliation: Institute of Structural and Molecular Biology, Division of Biosciences, University College London, Gower Street, London, WC1E 6BT, United Kingdom.
authors.forename: Ian
authors.initials: I
authors.lastname: Sillitoe
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, United Kingdom. Electronic address: thornton@ebi.ac.uk.
authors.forename: Janet M
authors.initials: JM
authors.lastname: Thornton
mesh_terms: D019143:Evolution, Molecular; D006801:Humans; D007535:Isomerases / Q000737:chemistry / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D007535:Isomerases