title: Use of pulmonary arterial hypertension-specific therapy in overweight or obese patients with obstructive sleep apnea and pulmonary hypertension.
abstract: Pulmonary hypertension (PH) in overweight or obese patients with obstructive sleep apnea (OSA) may be multifactorial. The effect of pulmonary artery hypertension (PAH)-specific drugs on PH and exercise capacity in such patients is unknown. We performed a retrospective review of overweight or obese patients with OSA and PH who were treated with PAH-specific therapy in our PH clinic. We identified 9 female and 2 male patients. The mean age ± SD was 54.9 ± 9.3 years. The mean pulmonary artery pressure at the time of diagnosis of PH was 39.8 ± 16.1 mmHg. The right atrial pressure was 11.1 ± 4.5 mmHg, the pulmonary artery wedge pressure was 14.1 ± 2.9 mmHg, the cardiac index was 2.6 ± 0.5 L/min/m(2), and the pulmonary vascular resistance index was 10.6 ± 7.1 Wood units/m(2). The indications for use of PAH-specific therapy were dyspnea in association with right heart failure (n = 4), persistent PH despite compliance with nocturnal positive airway pressure (PAP) therapy (n = 4), or inability to tolerate PAP therapy (n = 3). PH was treated with an endothelin receptor antagonist (n = 8) or a phosphodiesterase-5 inhibitor (n = 3). The 6-minute walk distance (6MWD) improved significantly, from 234 ± 49.7 to 258 ± 54.6 m (24 m [95% confidence interval (CI): 6.5-341.5 m]; P = 0.014) over a period of 4.4 ± 1.8 months (n = 8) and from 241.7 ± 48.5 to 289.9 ± 91 m (48 m [95% CI: 5.5-90.8 m]; P = 0.033) in those with a longer follow-up period of 12.1 ± 6.4 months (n = 7). The systolic pulmonary artery pressure dropped significantly, from 64 ± 25.2 to 42 ± 10.4 mmHg (22 mmHg [95% CI: 4-40 mmHg]; P = 0.024) over a period of 6.1 ± 4.1 months (n = 7). In conclusion, PAH-specific therapy resulted in significant improvement in both PH and 6MWD.
authors.affiliation: Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Jacksonville, Florida, USA.
authors.forename: Adil
authors.initials: A
authors.lastname: Shujaat
authors.affiliation: Department of Medicine, University of Florida, Jacksonville, Florida, USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Bellardini
authors.affiliation: Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Jacksonville, Florida, USA.
authors.forename: Ankur
authors.initials: A
authors.lastname: Girdhar
authors.affiliation: Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Jacksonville, Florida, USA.
authors.forename: Abubakr A
authors.initials: AA
authors.lastname: Bajwa
keywords: obstructive sleep apnea; pulmonary hypertension; therapy