title: Association of intercellular adhesion molecule‑1 gene polymorphism with coronary heart disease.
abstract: Intercellular adhesion molecule‑1 (ICAM‑1) is an important adhesion molecule that has a crucial role in lymphocyte migration and atherosclerosis pathogenesis activation. The aim of the present study was to explore the association between the rs5498 polymorphism of the ICAM‑1 gene and coronary heart disease (CHD). The rs5498 polymorphism of the ICAM‑1 gene was detected using polymerase chain reaction‑restriction fragment length polymorphism in 674 patients with CHD and 779 control subjects. The results showed that the frequency of the G allele was significantly higher in patients with CHD than that in controls (29.1 vs. 23.3%; P<0.001). The frequency of the AG+GG genotypes was higher in patients with CHD than that in controls (49.7 vs. 40.8%; P=0.001). Multiple logistic regression analysis showed that AG+GG was an independent risk factor for CHD (odds ratio, 1.919; 95% confidence intervals, 1.471‑2.503; P<0.001). For males, the frequencies of the G allele and AG+GG genotype were also higher in patients with CHD than those in control subjects (frequency of G allele, 29.9 vs. 22.7%; P<0.001; frequency of AG+GG genotype, 50.6 vs. 40.3%; P=0.001). For females, no significant differences in genotype or allele distribution were observed between the two groups. In conclusion, it was demonstrated in the present study that the rs5498 polymorphism of the ICAM‑1 gene was associated with CHD in males. Males with the G allele (AG and GG genotype) may therefore have a higher risk for CHD than those with the AA genotype.
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China.
authors.forename: Jun-Yi
authors.initials: JY
authors.lastname: Luo
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China.
authors.forename: Yi-Tong
authors.initials: YT
authors.lastname: Ma
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Xie
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China.
authors.forename: Yi-Ning
authors.initials: YN
authors.lastname: Yang
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China.
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Li
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China.
authors.forename: Zixiang
authors.initials: Z
authors.lastname: Yu
authors.affiliation: Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, Xinjiang 830054, P.R. China.
authors.forename: Bang-Dang
authors.initials: BD
authors.lastname: Chen
authors.affiliation: Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, Xinjiang 830054, P.R. China.
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D003327:Coronary Disease / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D060005:Genotyping Techniques; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics* / Q000378:metabolism; D008019:Life Style; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors
chemical_list: C573420:ICAM1 protein, human; D018799:Intercellular Adhesion Molecule-1