title: Association between β2-adrenoceptor gene polymorphisms and asthma risk: an updated meta-analysis.
abstract: BACKGROUND
  Evidence is increasingly accumulated about multiple roles for the β2-adrenoceptor gene in asthma. The results were inconsistent partly due to small sample sizes. To assess the association between β2-adrenoceptor gene polymorphisms and asthma risk, a meta-analysis was performed.
  
  
  METHODS
  We comprehensively searched the PubMed, EMBASE, BIOSIS Previews databases and extracted data from all eligible articles to estimate the association between β2-adrenoceptor gene polymorphisms and asthma risk. The pooled odds ratio (OR) with 95% confidence intervals (CIs) were calculated.
  
  
  RESULTS
  Thirty-seven studies involving 6648 asthma patients and 15943 controls were included in the meta-analysis. Overall, significant associations were found in allelic genetic model (OR = 1.06, 95% CI = 1.01 ∼ 1.12), recessive genetic model (OR = 1.11, 95% CI = 1.02 ∼ 1.21) for Arg/Gly16. Stratified by ethnicity and age, significant associations were also found in Asian population in allelic genetic model, recessive genetic model and addictive model. For Gln/Glu27, no significant association was found when we combined all eligible studies. Age stratification showed significant associations in adults in allelic genetic model and recessive genetic model, but no significant association was found among Asians and Caucasians in ethnicity stratification.
  
  
  CONCLUSIONS
  This meta-analysis implied that the β2-adrenoceptor Arg/Gly16 polymorphism was likely to contribute to asthma risk in Asian population. Gln/Glu27 polymorphism might be a contributor to asthma susceptibility for adults.
authors.affiliation: Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
authors.forename: Haojun
authors.initials: H
authors.lastname: Xie
authors.affiliation: Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
authors.forename: Yuanxiong
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
authors.forename: Yating
authors.initials: Y
authors.lastname: Huo
authors.affiliation: Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
authors.forename: Guohua
authors.initials: G
authors.lastname: Huang
authors.affiliation: Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Su
mesh_terms: D044466:Asian People / Q000208:ethnology / Q000235:genetics; D001249:Asthma / Q000208:ethnology* / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*; D044465:White People / Q000208:ethnology / Q000235:genetics
chemical_list: C553443:ADRB2 protein, human; D018343:Receptors, Adrenergic, beta-2