title: Alitretinoin (9-cis retinoic acid) is effective against pityriasis rubra pilaris: a retrospective clinical study.
abstract: Pityriasis rubra pilaris (PRP) is an uncommon cutaneous disease with disorder of keratinisation. Up to now, systemic retinoids like acitretin or isotretinoin seem to be the most effective therapeutic agents. However, no large trials on this rare disease have been published and no standardised treatment has been established so far. Recently, single case reports demonstrate beneficial effects of alitretinoin (9-cis retinoic acid) in patients with PRP. We performed a retrospective observational analysis of type I adult-onset patients with PRP (n = 5) treated with systemic alitretinoin in our department. Alitretinoin was highly effective in the treatment of PRP in 4 of 5 cases. PASI score was reduced significantly in the alitretinoin responders. We assume that alitretinoin could serve as an additional effective systemic treatment option for type I adult-onset PRP.
authors.affiliation: Department of Dermatology, SLK Hospital Heilbronn, DE- 74078 Heilbronn, Germany. philipp.amann@slk-kliniken.de.
authors.forename: Philipp M
authors.initials: PM
authors.lastname: Amann
authors.forename: Marijan
authors.initials: M
authors.lastname: Susic
authors.forename: Franziska
authors.initials: F
authors.lastname: Glüder
authors.forename: Hans
authors.initials: H
authors.lastname: Berger
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Krapf
authors.forename: Harald
authors.initials: H
authors.lastname: Löffler
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000077556:Alitretinoin; D005260:Female; D006801:Humans; D007641:Keratolytic Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010916:Pityriasis Rubra Pilaris / Q000175:diagnosis / Q000188:drug therapy*; D012074:Remission Induction; D012189:Retrospective Studies; D016896:Treatment Outcome; D014212:Tretinoin / Q000627:therapeutic use*
chemical_list: D007641:Keratolytic Agents; D000077556:Alitretinoin; D014212:Tretinoin