title: Protein homeostasis at the plasma membrane.
abstract: The plasma membrane (PM) and endocytic protein quality control (QC) in conjunction with the endosomal sorting machinery either repairs or targets conformationally damaged membrane proteins for lysosomal/vacuolar degradation. Here, we provide an overview of emerging aspects of the underlying mechanisms of PM QC that fulfill a critical role in preserving cellular protein homeostasis in health and diseases.
authors.affiliation: Department of Physiology and Research Group Focused on Protein Structure (GRASP), McGill University, Montreal, Quebec, Canada; and pirjo.apaja@mcgill.ca gergely.lukacs@mcgill.ca.
authors.forename: Pirjo M
authors.initials: PM
authors.lastname: Apaja
authors.affiliation: Department of Physiology and Research Group Focused on Protein Structure (GRASP), McGill University, Montreal, Quebec, Canada; and Department of Biochemistry, McGill University, Montreal, Quebec, Canada pirjo.apaja@mcgill.ca gergely.lukacs@mcgill.ca.
authors.forename: Gergely L
authors.initials: GL
authors.lastname: Lukacs
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000502:physiology*; D004705:Endocytosis / Q000502:physiology; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D008247:Lysosomes / Q000502:physiology; D008565:Membrane Proteins / Q000737:chemistry / Q000502:physiology*; D011487:Protein Conformation
chemical_list: D008565:Membrane Proteins