title: Evaluation of circulating irisin levels in healthy young individuals after a single 100,000 IU vitamin D dose.
abstract: Irisin is a newly discovered hormone produced by the muscle. This hormone is involved in glucose metabolism, muscle strength and energy expenditure. As vitamin D is also known as a key player in that field, we aimed to see if a single dose of 100,000 IU of vitamin D would modify circulating levels of irisin in 29 young adults. Irisin was determined with the Phoenix Elisa assay at day 0, day 3, day 7 day 15 and day 28 after the loading dose. If we observed a significant increase in 25(OH)D levels (from 19.8±8.4 ng/mL to 33.0±8.5 ng/mL), irisin levels remained constant throughout the study (median 104.5 ng/mL, with values ranging from 69.9 to 390.9 ng/mL). Interestingly, one subject presented irisin values that were three times higher than all the others.
authors.affiliation: Department of Clinical Chemistry, University of Liege, CHU Sart-Tilman, Liège, Belgium. Electronic address: Etienne.cavalier@chu.ulg.ac.be.
authors.forename: Étienne
authors.initials: É
authors.lastname: Cavalier
authors.affiliation: Faculty of Medicine, University of Saint-Étienne, Saint-Étienne, France.
authors.forename: Valentine
authors.initials: V
authors.lastname: Mismetti
authors.affiliation: Laboratoire d'Explorations fonctionnelles, Hôpital Necker-Enfants-Malades, Paris, France.
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Souberbielle
mesh_terms: D000328:Adult; D002762:Cholecalciferol / Q000008:administration & dosage*; D019587:Dietary Supplements; D005260:Female; D005353:Fibronectins / Q000097:blood*; D006801:Humans; D008297:Male; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood
chemical_list: C577593:FNDC5 protein, human; D005353:Fibronectins; D014807:Vitamin D; D002762:Cholecalciferol; C104450:25-hydroxyvitamin D
keywords: Energy; Irisin; Irisine; Muscle; Vitamin D; Vitamine D; Énergie