title: Stem cell-based organ replacements-airway and lung tissue engineering.
abstract: Tissue engineering requires the use of cells seeded onto scaffolds, often in conjunction with bioactive molecules, to regenerate or replace tissues. Significant advances have been made in recent years within the fields of stem cell biology and biomaterials, leading to some exciting developments in airway tissue engineering, including the first use of stem cell-based tissue-engineered tracheal replacements in humans. In addition, recent advances within the fields of scaffold biology and decellularization offer the potential to transplant patients without the use of immunosuppression.
authors.affiliation: UCL Centre for Stem Cells, Tissue Engineering and Regenerative Medicine, London, UK; The Royal National Throat, Nose and Ear Hospital, London, UK; UCL Ear Institute, University College London, 332 Gray׳s Inn Road, London WC1X 8EE, UK.
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Fishman
authors.affiliation: Department of Haematology, Royal Free Hospital, UCL, London, UK.
authors.forename: Mark
authors.initials: M
authors.lastname: Lowdell
authors.affiliation: UCL Centre for Stem Cells, Tissue Engineering and Regenerative Medicine, London, UK; The Royal National Throat, Nose and Ear Hospital, London, UK; UCL Ear Institute, University College London, 332 Gray׳s Inn Road, London WC1X 8EE, UK. Electronic address: m.birchall@ucl.ac.uk.
authors.forename: Martin A
authors.initials: MA
authors.lastname: Birchall
mesh_terms: D062088:Acellular Dermis; D021522:Bioartificial Organs; D019149:Bioreactors; D006801:Humans; D007830:Larynx / Q000637:transplantation*; D016040:Lung Transplantation / Q000379:methods*; D019736:Prostheses and Implants; D033581:Stem Cell Transplantation / Q000379:methods*; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds; D014132:Trachea / Q000637:transplantation*; D014182:Transplantation, Autologous; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous
keywords: Airway management; Artificial organs; Biocompatible materials; Bioreactors; Larynx; Regenerative medicine; Stem cells; Tissue engineering; Tissue scaffolds; Trachea; Transplantation