title: Proinflammatory cytokines and C-reactive protein in uveitis associated with Behçet's disease.
abstract: The aim of the present study was to determine the serum cytokine profile and levels of high sensitivity C-reactive protein (hsCRP) in patients with uveitis associated with Behçet's disease (BD) and to compare them with those obtained from healthy control subjects. We determined the serum concentration of interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-12p70, IL-17A, tumor necrosis factor-α (TNF-α), and hsCRP in 13 patients with active uveitis associated to BD, 24 inactive BD patients, and 20 controls. In a subgroup of 10 active patients, a second serum sample was obtained when the disease was inactive. Cytokine profiles and hsCRP levels were correlated with disease activity, severity, complications, and visual outcome. Levels of IFN-γ and TNF-α were significantly increased in patients with active uveitis associated to BD compared to controls (P < 0.05). IFN-γ, TNF-α, and hsCRP were significantly higher during active uveitis associated to BD compared to inactive disease (P < 0.05). Furthermore, IL-17A was significantly increased in patients with active BD without pharmacological treatment compared to controls (P < 0.05). No significant correlations were found with specific cytokine profiles and disease severity, visual outcome, or complications. In summary, increased serum levels of IFN-γ, TNF-α, IL-17A, and hsCRP were associated with active uveitis associated with BD and might serve as markers of disease activity.
authors.affiliation: Institut Clínic d'Oftalmologia, Hospital Clinic de Barcelona, University of Barcelona, Sabino de Arana 1, 08028 Barcelona, Spain.
authors.forename: Marina
authors.initials: M
authors.lastname: Mesquida
authors.affiliation: Institut Clínic d'Oftalmologia, Hospital Clinic de Barcelona, University of Barcelona, Sabino de Arana 1, 08028 Barcelona, Spain ; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
authors.forename: Blanca
authors.initials: B
authors.lastname: Molins
authors.affiliation: Institut Clínic d'Oftalmologia, Hospital Clinic de Barcelona, University of Barcelona, Sabino de Arana 1, 08028 Barcelona, Spain.
authors.forename: Victor
authors.initials: V
authors.lastname: Llorenç
authors.affiliation: Institut Clínic d'Oftalmologia, Hospital Clinic de Barcelona, University of Barcelona, Sabino de Arana 1, 08028 Barcelona, Spain.
authors.forename: Maite
authors.initials: M
authors.lastname: Sainz de la Maza
authors.affiliation: Rheumatology Department, Hospital Clinic de Barcelona, University of Barcelona, Barcelona, Spain.
authors.forename: María Victoria
authors.initials: MV
authors.lastname: Hernandez
authors.affiliation: Autoimmune Disease Department, Hospital Clinic de Barcelona, University of Barcelona, Barcelona, Spain.
authors.forename: Gerard
authors.initials: G
authors.lastname: Espinosa
authors.affiliation: Institut Clínic d'Oftalmologia, Hospital Clinic de Barcelona, University of Barcelona, Sabino de Arana 1, 08028 Barcelona, Spain.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Adán
mesh_terms: D000328:Adult; D000368:Aged; D001528:Behcet Syndrome / Q000097:blood* / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D020381:Interleukin-17 / Q000097:blood; D008297:Male; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D055815:Young Adult
chemical_list: D016207:Cytokines; D020381:Interleukin-17; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma; D002097:C-Reactive Protein