title: Correlation between behavioural and psychological symptoms of Alzheimer type dementia and plasma homocysteine concentration.
abstract: The relationship between plasma homocysteine and behavioral and psychological symptoms of dementia (BPSD) has not been specifically investigated in previous research. In this study, we compared plasma homocysteine (Hcy) among 40 Alzheimer's disease (AD) patients with BPSD, 37 AD patients without BPSD, and 39 healthy controls. Our results evidenced that the plasma homocysteine levels in AD patients with BPSD and without BPSD were higher than healthy controls and that the plasma homocysteine concentration in AD patients with BPSD was the highest among the three groups. Significant correlation between plasma homocysteine concentration and cognitive decline and duration of dementia was observed, but there was no correlation between BPSD and cognitive dysfunction or duration of dementia. In conclusion, this study showed for the first time that BPSD were associated with plasma homocysteine concentration in Alzheimer's dementia, and the results supported that hyperhomocysteine may take part in the pathogenesis of BPSD.
authors.affiliation: Department of Geriatric, Qingdao Mental Health Center, Qingdao 266034, China.
authors.forename: Zhanjie
authors.initials: Z
authors.lastname: Zheng
authors.affiliation: Department of Geriatric, Qingdao Mental Health Center, Qingdao 266034, China.
authors.forename: Jindong
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Geriatric, Qingdao Mental Health Center, Qingdao 266034, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Yi
authors.affiliation: Department of Geriatric, Qingdao Mental Health Center, Qingdao 266034, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Yu
authors.affiliation: Department of Geriatric, Qingdao Mental Health Center, Qingdao 266034, China.
authors.forename: Lingli
authors.initials: L
authors.lastname: Kong
authors.affiliation: Department of Geriatric, Qingdao Mental Health Center, Qingdao 266034, China.
authors.forename: Weizhen
authors.initials: W
authors.lastname: Cui
authors.affiliation: Department of Geriatric, Qingdao Mental Health Center, Qingdao 266034, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.affiliation: Office of Director of Hospital, Qingdao Mental Health Center, Qingdao 266034, China.
authors.forename: Chunxia
authors.initials: C
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000097:blood* / Q000473:pathology*; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index
chemical_list: D006710:Homocysteine