title: Influence of gastric emptying on the control of postprandial glycemia: physiology and therapeutic implications.
abstract: The maintenance of glucose homeostasis is complex and involves, besides the secretion and action of insulin and glucagon, a hormonal and neural mechanism, regulating the rate of gastric emptying. This mechanism depends on extrinsic and intrinsic factors. Glucagon-like peptide-1 secretion regulates the speed of gastric emptying, contributing to the control of postprandial glycemia. The pharmacodynamic characteristics of various agents of this class can explain the effects more relevant in fasting or postprandial glucose, and can thus guide the individualized treatment, according to the clinical and pathophysiological features of each patient.
authors.affiliation: Universidade Estadual de Campinas, Campinas, SP, Brazil.
authors.forename: Marcos Antonio
authors.initials: MA
authors.lastname: Tambascia
authors.affiliation: Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
authors.forename: Domingos Augusto Cherino
authors.initials: DA
authors.lastname: Malerbi
authors.affiliation: Centro de Pesquisas Clínicas, São Paulo, SP, Brazil.
authors.forename: Freddy Goldberg
authors.initials: FG
authors.lastname: Eliaschewitz
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D005746:Gastric Emptying / Q000502:physiology*; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism*; D006801:Humans; D019518:Postprandial Period / Q000502:physiology*
chemical_list: D001786:Blood Glucose; D052216:Glucagon-Like Peptide 1