title: Pyridine-phosphinimine ligand-accelerated Cu(I)-catalyzed azide-alkyne cycloaddition for preparation of 1-(pyridin-2-yl)-1,2,3-triazole derivatives.
abstract: A series of phosphinimine ligands were designed and used in the Cu(i)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction of tetrazolo[1,5-a]pyridines and alkynes for the first time. By optimizing the reaction conditions, an efficient catalytic system (CuCl/2-PyCH2N[double bond, length as m-dash]P(t)Bu3) was developed to give 1-(pyridin-2-yl)-1,2,3-triazole derivatives in moderate to excellent yields (46-98%).
authors.affiliation: School of Chemical & Chemical Engineering, Inner Mongolia University, Hohhot 010021, P. R. China. haozhang@imu.edu.cn zh_hjf@hotmail.com.
authors.forename: Ranfeng
authors.initials: R
authors.lastname: Sun
authors.forename: Huangdong
authors.initials: H
authors.lastname: Wang
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Hu
authors.forename: Jiudong
authors.initials: J
authors.lastname: Zhao
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D061565:Cycloaddition Reaction; D007097:Imines / Q000737:chemistry*; D008024:Ligands; D008968:Molecular Conformation; D011725:Pyridines / Q000737:chemistry*; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D001386:Azides; D007097:Imines; D008024:Ligands; D011725:Pyridines; D014230:Triazoles; D003300:Copper; C023666:pyridine