title: Low-voltage pattern and absence of sleep-wake cycles are associated with severe hemorrhage and death in very preterm infants.
abstract: Amplitude integrated electroencephalogaphy (aEEG) is becoming an important tool for the assessment of cerebral activity in preterm newborns. Describing the relationship between early aEEG patterns and intraventricular hemorrhage (IVH) can improve our knowledge of neurological injury in the preterm newborn. The aim of this prospective study was to identify early changes in the aEEG in premature newborns that could be associated to severe neurological lesion/death. Preterm newborns with a birth weight ≤1,500 g and/or 32 weeks of gestation were included. aEEG monitoring was performed during the first 72 h of life. A qualitative analysis of the aEEG recordings was performed, based on continuity, sleep-wake cycles (SWCs), inferior lower margin amplitude (LMA), and bandwidth (BW). Key outcomes were severe IVH and/or death. Ninety-two subjects were included (mean gestational age 28 weeks). In 28.6 % of subjects with HIV III/IHP, a low-voltage pattern was observed. A statistically significant relationship was found between low-voltage tracings and death and neurological lesion/death. Absent SWCs during the first 72 h were also related to death.
  
  
  CONCLUSIONS
  Early aEEG patterns can be predictive of neurological outcome in the preterm newborn. Low-voltage tracing and absence of SWCs are associated with severe neurological lesions/death.
authors.affiliation: Department of Neonatology, Hospital Universitario Puerta del Mar, Av. Ana de Viya 21, 11009, Cádiz, Spain, isabenavente@gmail.com.
authors.forename: Isabel
authors.initials: I
authors.lastname: Benavente-Fernández
authors.forename: Simón Pedro
authors.initials: SP
authors.lastname: Lubián-López
authors.forename: Gema
authors.initials: G
authors.lastname: Jiménez-Gómez
authors.forename: Alfonso María
authors.initials: AM
authors.lastname: Lechuga-Sancho
authors.forename: Monica
authors.initials: M
authors.lastname: Garcia-Alloza
mesh_terms: D002543:Cerebral Hemorrhage / Q000175:diagnosis / Q000401:mortality*; D015331:Cohort Studies; D004569:Electroencephalography / Q000379:methods*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D011446:Prospective Studies; D020178:Sleep Disorders, Circadian Rhythm / Q000175:diagnosis*