title: Bilateral sertoli-leydig cell tumor in a primigravida: a rare case.
abstract: We present a unique case of incidentally discovered bilateral Sertoli Leydig cell tumour in a primigravida who displayed no features of virilization. The apha fetoprotein levels were elevated. Magnetic resonance imaging was suggestive of ovarian tumors, possibly germ cell tumor. Bilateral salpingo-oophorectomy was performed and histopathology showed features of Sertoli Leydig cell tumor with intermediate to poor differentiation. Immunohistochemistry was positive for calretinin and inhibin, while cytokeratin was negative. Four courses of bleomycin-, etoposide- and cisplatin-based chemotherapy regimen was started, but the patient aborted while receiving the second cycle of chemotherapy. She received the remaining two cycles of chemotherapy and is now on close follow up with monitoring of serum inhibin levels to detect any tumor recurrence. Bilateral Sertloli Leydig cell tumor has not been reported previously in a pregnant female. The aim of this article is to describe the clinical, radiological and pathological features and management of this rare entity.
authors.affiliation: Departments of Cytology and Gynecological Pathology, Post Graduate Institute of Medical Education and Research , Chandigarh, India.
authors.forename: Ruchita
authors.initials: R
authors.lastname: Tyagi
authors.affiliation: Departments of Cytology and Gynecological Pathology, Post Graduate Institute of Medical Education and Research , Chandigarh, India.
authors.forename: Parimal
authors.initials: P
authors.lastname: Agrawal
authors.affiliation: Departments of Cytology and Gynecological Pathology, Post Graduate Institute of Medical Education and Research , Chandigarh, India.
authors.forename: Raje
authors.initials: R
authors.lastname: Nijhawan
authors.affiliation: Departments of Obstetrics and Gynecology, Post Graduate Institute of Medical Education and Research , Chandigarh, India.
authors.forename: Grv
authors.initials: G
authors.lastname: Prasad
keywords: Leydig; Sertoli; bilateral; pregnant