title: Advances in biomathematical modeling for PET neuroreceptor imaging.
abstract: The quantitative application of PET neuroreceptor imaging to study pathophysiology, diagnostics and drug development has continued to benefit from associated advances in biomathematical imaging methodology. We review some of these advances with particular focus on multi-modal image processing, tracer kinetic modeling, occupancy studies and discovery and development of novel radioligands.:
authors.affiliation: Department of Medicine, Imperial College London, London, UK. Electronic address:roger.gunn@imanova.co.uk.
authors.forename: Roger N
authors.initials: RN
authors.lastname: Gunn
authors.affiliation: Department of Medicine, Imperial College London, London, UK.
authors.forename: Qi
authors.initials: Q
authors.lastname: Guo
authors.affiliation: Imanova Limited, Burlington Danes Building, Imperial College London, Hammersmith Hospital, London, Du Cane Road, W12 0NN, UK.
authors.forename: Cristian A
authors.initials: CA
authors.lastname: Salinas
authors.affiliation: FMRIB Centre, Department of Clinical Neurology, University of Oxford, Oxford, UK.
authors.forename: Andri C
authors.initials: AC
authors.lastname: Tziortzi
authors.affiliation: Imanova Limited, Burlington Danes Building, Imperial College London, Hammersmith Hospital, London, Du Cane Road, W12 0NN, UK.
authors.forename: Graham E
authors.initials: GE
authors.lastname: Searle