title: [Clinical significance of TGF-β1 in children with primary IgA nephropathy].
abstract: OBJECTIVE
  To investigate the clinical significance of transforming growth factor-beta 1 (TGF-β1) in children with primary IgA nephropathy (IgAN).
  
  
  METHODS
  Thirty children who were diagnosed with primary IgAN by renal biopsy between May 2008 and October 2012 were included in the study. Thirty healthy children were used as the control group. Urinary and blood TGF-β1 levels were measured using enzyme-linked immunosorbent assay, and the protein expression of TGF-β1 in the renal tissue was measured by immunohistochemistry. The correlation between TGF-β1 levels in blood, urine, and renal tissue and their relationship with clinical indices were analyzed.
  
  
  RESULTS
  Children with primary IgAN had significantly higher urinary and blood TGF-β1 levels than the control group (P<0.01). Urinary TGF-β1 level was positively correlated with the pathological grade of renal tissue (r=0.557, P=0.001), and a significant positive correlation was also found between the TGF-β1 expression in the renal tissue and the pathological grade of renal tissue (r=0.682, P<0.01). There was no correlation between TGF-β1 levels in blood and renal tissue (r=0.038, P=0.844).
  
  
  CONCLUSIONS
  Urinary TGF-β1 level is significantly positively correlated with the pathological severity of disease in children with primary IgAN. Clinical measurement of urinary TGF-β1 may be of great practical value in predicting the progression and prognosis of chronic nephropathy.
authors.affiliation: Department of Pediatrics, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830011, China. ggyyff001@163.com.
authors.forename: Hong-Tao
authors.initials: HT
authors.lastname: Zhu
authors.forename: Liang
authors.initials: L
authors.lastname: Ru
authors.forename: Yan-Fang
authors.initials: YF
authors.lastname: Guo
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D005922:Glomerulonephritis, IGA / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007668:Kidney / Q000737:chemistry / Q000473:pathology; D008297:Male; D053773:Transforming Growth Factor beta1 / Q000032:analysis / Q000502:physiology* / Q000652:urine
chemical_list: D053773:Transforming Growth Factor beta1