title: Efficacy and safety of Labisia pumila var alata water extract among pre- and postmenopausal women.
abstract: This study evaluated the effectiveness and safety of Labisia pumila var alata (L. pumila) water extract for improving quality of life, cardiovascular and hormonal balance. A randomized, double-blind, placebo-controlled, parallel group, 16-week study in healthy pre- and postmenopausal women aged 40-60 years was conducted in Kelantan, Malaysia. The subjects were randomized to 400 mg propriety extract of L. pumila or placebo. A Women's Health Questionnaire was used to assess quality of life. Repeated-measures analysis of variance was used to evaluate the data. A total of 197 subjects (L. pumila: n=102 and placebo: n=95) were analyzed. Subjects in the herbal group showed improved memory/concentration, vasomotor symptoms, menstrual symptoms, and sleep problems by 8.3%, 15.9%, 11.8%, and 31.0%, respectively. The greatest improvement was observed for the question: "I get frightened or panic feelings for apparently no reason at all" with a 53% decrease as compared with placebo. Improvements were also seen in the cardiovascular parameters, and the safety profiles were normal. Postmenopausal women supplemented with L. pumila showed no changes in gynecological relevant hormones luteinizing hormone (LH), follicle-stimulating hormone (FSH), and 17β-Estradiol. Water extract of L. pumila was shown to be safe and effective for improving several parameters of quality of life and cardiovascular risks factors (total cholesterol [TC], low-density lipoprotein cholesterol [LDL-C]).
authors.affiliation: 1 Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia .
authors.forename: Mohd Noor
authors.initials: MN
authors.lastname: Norhayati
authors.forename: Annie
authors.initials: A
authors.lastname: George
authors.forename: Nik Hussain Nik
authors.initials: NH
authors.lastname: Hazlina
authors.forename: Abdul Kadir
authors.initials: AK
authors.lastname: Azidah
authors.forename: Hassan Intan
authors.initials: HI
authors.lastname: Idiana
authors.forename: Kim Sooi
authors.initials: KS
authors.lastname: Law
authors.forename: Ismail Shaiful
authors.initials: IS
authors.lastname: Bahari
authors.forename: Wan Mohamed Wan
authors.initials: WM
authors.lastname: Zahiruddin
authors.forename: Eckehard
authors.initials: E
authors.lastname: Liske
authors.forename: Abas
authors.initials: A
authors.lastname: Azreena
mesh_terms: D000328:Adult; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006801:Humans; D008568:Memory / Q000187:drug effects; D008875:Middle Aged; D010936:Plant Extracts / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology*; D017698:Postmenopause / Q000187:drug effects* / Q000378:metabolism / Q000523:psychology; D017697:Premenopause / Q000187:drug effects* / Q000378:metabolism / Q000523:psychology; D029623:Primulaceae / Q000737:chemistry*; D011788:Quality of Life
chemical_list: D010936:Plant Extracts; D005640:Follicle Stimulating Hormone
keywords: Labisia pumila var alata; cardiovascular risk factors; hormonal profile; quality of life; safety profiles