title: [Plasma amino acid profiling of "same symptom for different disease" in Uyghur medicine based on high-performance liquid chromatography].
abstract: OBJECTIVE
  To determine the plasma amino acid metabolism of "same symptom for different diseases" in different cancer patients in Uyghur medicine.
  
  
  METHODS
  Plasma amino acid concentration was tested by high-performance liquid chromatography (HPLC) in cancer patients with different symptom, and the spectral profiles were subjected to a t-test for statistical significance.
  
  
  RESULTS
  Compared with the healthy group, lung cancer, cervical cancer, breast cancer and gastric cancer patients with abnormal Savda had lower concentration of plasma amino acids except some amino acids. Lung cancer patients with abnormal Savda had higher concentration of plasma phenylalanine, serine, cystine, valine, isoleucine, leucine and aspartic acid than Unsavda patients (P<0.05). Cervical cancer patients with abnormal Savda had low concentration of plasma arginine, but higher concentration of plasma cystine than Unsavda patients (P<0.05). Breast cancer patients with abnormal Savda had higher concentration of plasma leucine, serine, taurine, cystine, tyrosine, valine, isoleucine and asparagine than Unsavda patients (P<0.05). Gastric cancer patients with abnormal Savda had high concentration of plasma cystine but lower concentration of plasma phenylalanine, threonine and arginine than Unsavda patients (P<0.05).
  
  
  CONCLUSIONS
  Different tumor patients with abnormal Savda have common characteristics and significant differences.
authors.affiliation: College of Pharmacy, The First Affiliated Hospital, Xinjiang Medical University, Urumqi 830011, China batur72@163.com.
authors.forename: Batur
authors.initials: B
authors.lastname: Mamtimin
authors.forename: Halmurat
authors.initials: H
authors.lastname: Upur
authors.forename: Bin
authors.initials: B
authors.lastname: Kong
authors.forename: Maynur
authors.initials: M
authors.lastname: Eli
authors.forename: Askar
authors.initials: A
authors.lastname: Turahun
mesh_terms: D000596:Amino Acids / Q000097:blood*; D001120:Arginine; D001224:Aspartic Acid; D002851:Chromatography, High Pressure Liquid; D003553:Cystine; D006801:Humans; D007532:Isoleucine; D007930:Leucine; D008516:Medicine, Chinese Traditional; D009369:Neoplasms / Q000097:blood*; D012694:Serine; D014443:Tyrosine; D014633:Valine
chemical_list: D000596:Amino Acids; D007532:Isoleucine; D001224:Aspartic Acid; D014443:Tyrosine; D012694:Serine; D003553:Cystine; D001120:Arginine; D007930:Leucine; D014633:Valine