title: Synthesis, characterization and (11) C-radiolabeling of aminophenyl benzothiazoles: structural effects on the alkylation of amino group.
abstract: Several aminophenyl benzothiazoles were prepared with a view to using them as amyloid binding agents for imaging β-amyloid in Alzheimer's disease. These precursors were radiolabeled with (11) C-positron-emitting radioisotope using an automated synthesizer and selected radiolabeled compounds were further purified by HPLC. Our results demonstrate that changes in structure have a major influence on the radioactive yield and the ease with which the radiolabel can be introduced. Aminophenyl benzothiazoles with an attached isopropyl group resisted dialkylation perhaps due to steric hindrance caused by this group. Straight chain attachment of methyl, ethyl, butyl, and crotyl groups in the structure decreased the radiochemical yield. Notably, the o-aminophenyl benzothiazole derivatives were difficult to alkylate despite stringent experimental conditions. This reactivity difference is attributed to the hydrogen bonding characteristics of the o-amino group with the nitrogen atom of the thiazole ring.
authors.affiliation: Centre for Advanced Imaging, The University of Queensland, St. Lucia, Brisbane, 4072, Australia.
authors.forename: T K
authors.initials: TK
authors.lastname: Venkatachalam
authors.forename: D H R
authors.initials: DH
authors.lastname: Stimson
authors.forename: R
authors.initials: R
authors.lastname: Bhalla
authors.forename: G K
authors.initials: GK
authors.lastname: Pierens
authors.forename: D C
authors.initials: DC
authors.lastname: Reutens
mesh_terms: D000478:Alkylation; D052160:Benzothiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D002250:Carbon Radioisotopes / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic / Q000295:instrumentation / Q000379:methods*; D006860:Hydrogen Bonding
chemical_list: D052160:Benzothiazoles; D002250:Carbon Radioisotopes
keywords: Synthra; aminophenyl benzothiazole; radiolabeling; synthesis