title: A Quantitative LQ-based Model for Lung Injury in Radiotherapy.
abstract: Establishing a new bio-mathematical model, named quantitative LQ-based (qLQB) model, that can evaluate the radio-toxicity of lung. We assume that each Function Subunit (FSU) of lung is equal and representative in functional status. Based on the Linear-Quadratic model (LQ model), we had derived a model to calculate the ratio/percent (R/P) between damaged cell/FSU and entire cell/FSU of lung for radiation dose response. We can analyse radiation pneumonia probability (RPP) based on the R/P. Forty-five 3D plans from forty-five randomly selected lung cancer patients were generated using the ELEKTA precise 2.12 treatment planning system. The qLQB was tested against the widely used Lyman-Kutcher-Burman model (LKB model). There was no distinct statistical difference in analyzing RPP between using the qLQB model and the LKB model (p = 0.412). The proposed qLQB model was found to be efficient and reliable for analyzing RPP.
authors.affiliation: Radiation Oncology Center, Yunnan Tumor Hospital, NO. 519, Kunzhou Road, XiShan District, Kunming, Yunnan 650118, China Radiation Oncology Center, The Third Affiliated Hospital of Kunming Medical College, NO. 519, Kunzhou Road, XiShan District, Kunming, Yunnan 650118, China These authors contributed equally to this work.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: Radiation Oncology Center, Yunnan Tumor Hospital, NO. 519, Kunzhou Road, XiShan District, Kunming, Yunnan 650118, China Radiation Oncology Center, The Third Affiliated Hospital of Kunming Medical College, NO. 519, Kunzhou Road, XiShan District, Kunming, Yunnan 650118, China These authors contributed equally to this work. bh001925@163.com.
authors.forename: Wenhui
authors.initials: W
authors.lastname: Li
authors.affiliation: Radiation Oncology Center, Yunnan Tumor Hospital, NO. 519, Kunzhou Road, XiShan District, Kunming, Yunnan 650118, China Radiation Oncology Center, The Third Affiliated Hospital of Kunming Medical College, NO. 519, Kunzhou Road, XiShan District, Kunming, Yunnan 650118, China These authors contributed equally to this work.
authors.forename: Han
authors.initials: H
authors.lastname: Bai
authors.affiliation: Radiation Oncology Center, Yunnan Tumor Hospital, NO. 519, Kunzhou Road, XiShan District, Kunming, Yunnan 650118, China Radiation Oncology Center, The Third Affiliated Hospital of Kunming Medical College, NO. 519, Kunzhou Road, XiShan District, Kunming, Yunnan 650118, China These authors contributed equally to this work.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Cui
authors.affiliation: Radiation Oncology Center, Yunnan Tumor Hospital, NO. 519, Kunzhou Road, XiShan District, Kunming, Yunnan 650118, China Radiation Oncology Center, The Third Affiliated Hospital of Kunming Medical College, NO. 519, Kunzhou Road, XiShan District, Kunming, Yunnan 650118, China.
authors.forename: Jiyong
authors.initials: J
authors.lastname: Qin
authors.affiliation: Radiation Oncology Center, Yunnan Tumor Hospital, NO. 519, Kunzhou Road, XiShan District, Kunming, Yunnan 650118, China Radiation Oncology Center, The Third Affiliated Hospital of Kunming Medical College, NO. 519, Kunzhou Road, XiShan District, Kunming, Yunnan 650118, China.
authors.forename: Li
authors.initials: L
authors.lastname: Chang
mesh_terms: D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008168:Lung / Q000473:pathology / Q000502:physiology* / Q000528:radiation effects*; D008175:Lung Neoplasms / Q000532:radiotherapy; D008962:Models, Theoretical; D011832:Radiation Injuries / Q000175:diagnosis / Q000517:prevention & control*; D017564:Radiation Pneumonitis / Q000175:diagnosis / Q000517:prevention & control*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000295:instrumentation / Q000379:methods*
keywords: Lyman-Kutcher-Burman (LKB) model; Quantitative LQ-based (qLQB) model; Radiation pneumonia probability.