title: Do synchronous airway lesions predict treatment failure after adenotonsillectomy in children less than 3 years of age with obstructive sleep apnea?
abstract: OBJECTIVE
  Determine the efficacy of adenotonsillectomy and the role of synchronous airway lesions in treatment failure in children younger than 3 years of age with obstructive sleep apnea.
  
  
  METHODS
  A retrospective chart review was conducted for children younger than 3 years of age with obstructive sleep apnea who were evaluated and treated at a tertiary care hospital between 2005 and 2011. All participants underwent adenotonsillectomy or powered-intracapsular tonsillectomy with adenoidectomy and had both pre- and post-operative polysomnograms. Children eligible for airway evaluation underwent flexible laryngoscopy, direct laryngoscopy or bronchoscopy. For analysis, participants were categorized as cured or not-cured with an obstructive apnea-hypopnea index (OAHI) threshold of ≥ 1.4 indicating residual obstructive sleep apnea.
  
  
  RESULTS
  Thirty-nine children met inclusion criteria and 41% had a post-operative OAHI≤ 1.4 by polysomnogram. Children failing adenotonsillectomy, (OAHI ≥ 1.4) had a significantly higher pre-operative OAHI (p < 0.001) and lower nadir SpO(2) (p < 0.03) than those considered cured. Thirty-eight percent of the total population underwent airway evaluation, and synchronous airway lesions were identified in 60% of that cohort. None of the children required surgery for their synchronous airway lesions and there was no significant difference between outcome groups in number of patients who underwent airway evaluation or had synchronous airway lesions (p = 1 and p = 0.14, respectively).
  
  
  CONCLUSIONS
  Adenotonsillectomy is effective for obstructive sleep apnea in children younger than 3 years of age and the presence of a synchronous airway lesion does not necessarily predict treatment failure.
authors.affiliation: Cleveland Clinic, Head and Neck Institute, Cleveland, OH, USA.
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Michelson
authors.affiliation: Cleveland Clinic, Head and Neck Institute, Cleveland, OH, USA.
authors.forename: Karen
authors.initials: K
authors.lastname: Hawley
authors.affiliation: Cleveland Clinic, Head and Neck Institute, Cleveland, OH, USA.
authors.forename: Samantha
authors.initials: S
authors.lastname: Anne
mesh_terms: D000233:Adenoidectomy; D001999:Bronchoscopy; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007818:Laryngeal Diseases / Q000175:diagnosis*; D008297:Male; D017286:Polysomnography; D011184:Postoperative Period; D012189:Retrospective Studies; D020181:Sleep Apnea, Obstructive / Q000601:surgery*; D014068:Tonsillectomy; D017211:Treatment Failure; D016896:Treatment Outcome
keywords: Adenoidectomy; Apnea; Bronchoscopy; Obstructive; Sleep; Tonsillectomy