title: The miR-29 family in hematological malignancies.
abstract: BACKGROUND
  MicroRNAs are short non-coding regulators of gene expression. The human miR-29 family consists of three members: miR-29a, miR-29b and miR-29c. Members of this family were found to be aberrantly expressed in various types of tumors, including hematological malignancies. This family was described to have both oncogenic and tumor suppressor features influencing various pathological processes, such as tumor growth and apoptosis. This review summarizes current knowledge about the miR-29 family in selected hematological malignancies.
  
  
  CONCLUSIONS
  Recent research of miR-29 family in hematological malignancies has proven its oncogenic as well as tumor suppressive potential. Nevertheless, the level of current evidence is not sufficient, and data remain inconclusive.
authors.affiliation: Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
authors.forename: Barbora
authors.initials: B
authors.lastname: Fiserova
authors.affiliation: Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.|Department of Clinical Hematology, University Hospital Brno.
authors.forename: Lenka
authors.initials: L
authors.lastname: Kubiczkova
authors.affiliation: Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.|Department of Clinical Hematology, University Hospital Brno.
authors.forename: Lenka
authors.initials: L
authors.lastname: Sedlarikova
authors.affiliation: Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.|Department of Clinical Hematology, University Hospital Brno.
authors.forename: Roman
authors.initials: R
authors.lastname: Hajek
authors.affiliation: Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.|Department of Clinical Hematology, University Hospital Brno.
authors.forename: Sabina
authors.initials: S
authors.lastname: Sevcikova
mesh_terms: D017209:Apoptosis / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D016922:Cellular Senescence / Q000235:genetics; D005109:Extracellular Matrix / Q000235:genetics; D016147:Genes, Tumor Suppressor / Q000502:physiology; D019337:Hematologic Neoplasms / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000502:physiology*
chemical_list: C532045:MIRN29a microRNA, human; D035683:MicroRNAs
keywords: circulating miRNA; hematological malignancy; miR-29 family; microRNA