title: Host-pathogen co-evolution and glycan interactions.
abstract: Noroviruses and rotavirus A bind to polymorphic glycans of the histo-blood group type (HBGAs). Norovirus strains that bind to HBGAs can collectively infect all humans but each strain only infects a subgroup of the population, suggesting a past co-evolution that led to a trade-off where the human population is partly protected whilst the virus circulation is maintained. We termed 'Herd Innate Protection' the host species partial protection provided by the HBGAs polymorphism. Given its recent emergence, high virulence and HBGAs attachment, RHDV provides a model for studying calicivirus-host co-evolution. Field observations documented evolution of the virus ability to recognize the host HBGAs diversity and reciprocal strain-dependent selection of HBGA phenotypes following outbreaks, indicating host-pathogen co-evolution involving glycan polymorphisms.
authors.affiliation: Inserm, UMR 892; CNRS, UMR 6299; Université de Nantes, IRS UN, 8 Quai Moncousu, BP 70721, 44007 Nantes cedex 1, France. Electronic address: Jacques.le-pendu@inserm.fr.
authors.forename: Jacques
authors.initials: J
authors.lastname: Le Pendu
authors.affiliation: Inserm, UMR 892; CNRS, UMR 6299; Université de Nantes, IRS UN, 8 Quai Moncousu, BP 70721, 44007 Nantes cedex 1, France.
authors.forename: Kristina
authors.initials: K
authors.lastname: Nyström
authors.affiliation: Inserm, UMR 892; CNRS, UMR 6299; Université de Nantes, IRS UN, 8 Quai Moncousu, BP 70721, 44007 Nantes cedex 1, France; Oniris- Ecole Nationale Vétérinaire, Agroalimentaire et de l'Alimentation Nantes Atlantique, 102 route de Gachet, 44300 Nantes, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Ruvoën-Clouet
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002139:Caliciviridae / Q000235:genetics* / Q000378:metabolism*; D017250:Caliciviridae Infections / Q000235:genetics* / Q000378:metabolism* / Q000821:virology; D006801:Humans; D011134:Polysaccharides / Q000378:metabolism*; D011991:Receptors, Virus / Q000378:metabolism*
chemical_list: D011134:Polysaccharides; D011991:Receptors, Virus