title: Effects of agave nectar versus sucrose on weight gain, adiposity, blood glucose, insulin, and lipid responses in mice.
abstract: Agave nectar is a fructose-rich liquid sweetener derived from a plant, and is often promoted as a low glycemic alternative to refined sugar. However, little scientific research has been conducted in animals or humans to determine its metabolic and/or health effects. The aim of this study was to explore the influence of agave nectar versus sucrose on weight gain, adiposity, fasting plasma blood glucose, insulin, and lipid levels. Eighteen (n=18) male ICR mice (33.8±1.6 g) were divided into two groups (n=6 for agave nectar and n=12 for sucrose) and provided free access to one of two diets of equal energy densities differing only in a portion of the carbohydrate provided. Diets contained 20% carbohydrate (by weight of total diet) from either raw agave nectar or sucrose. Epididymal fat pads were excised, and blood was collected after 34 days. Weight gain (4.3±2.2 vs. 8.4±3.4 g), fat pad weights (0.95±0.54 vs. 1.75±0.66 g), plasma glucose (77.8±12.2 vs. 111.0±27.9 mg/dL), and insulin (0.61±0.29 vs. 1.46±0.81 ng/mL) were significantly lower (P≤.05) for agave nectar-fed mice compared to sucrose-fed mice respectively. No statistically significant differences in total cholesterol or triglycerides were detected. These results suggest that in comparison to sucrose, agave nectar may have a positive influence on weight gain and glucose control. However, more research with a larger sample of animals and/or with human subjects is warranted.
authors.affiliation: School of Exercise and Nutritional Sciences, San Diego State University , San Diego, California, USA .
authors.forename: Shirin
authors.initials: S
authors.lastname: Hooshmand
authors.forename: Brittany
authors.initials: B
authors.lastname: Holloway
authors.forename: Tricia
authors.initials: T
authors.lastname: Nemoseck
authors.forename: Sarah
authors.initials: S
authors.lastname: Cole
authors.forename: Yumi
authors.initials: Y
authors.lastname: Petrisko
authors.forename: Mee Young
authors.initials: MY
authors.lastname: Hong
authors.forename: Mark
authors.initials: M
authors.lastname: Kern
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D050154:Adiposity / Q000187:drug effects; D027882:Agave; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D004032:Diet; D019422:Dietary Sucrose / Q000009:adverse effects / Q000494:pharmacology*; D005632:Fructose / Q000009:adverse effects / Q000494:pharmacology; D007328:Insulin / Q000097:blood*; D008055:Lipids / Q000097:blood; D008297:Male; D008813:Mice, Inbred ICR; D009765:Obesity / Q000097:blood / Q000209:etiology; D057048:Plant Nectar / Q000009:adverse effects / Q000494:pharmacology*; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D001786:Blood Glucose; D019422:Dietary Sucrose; D007328:Insulin; D008055:Lipids; D057048:Plant Nectar; D005632:Fructose
keywords: cholesterol; fructose; glucose; obesity; triglycerides