title: Effects of magnesium supplements on blood pressure, endothelial function and metabolic parameters in healthy young men with a family history of metabolic syndrome.
abstract: OBJECTIVE
  Magnesium plays an important role in the modulation of vascular tone and endothelial function and can regulate glucose and lipid metabolism. Patients with hypertension, metabolic syndrome (MetS) and diabetes mellitus (T2DM) have low body magnesium content; indeed, magnesium supplementation has been shown to have a positive effect on blood pressure (BP) and gluco-metabolic parameters. The aim of our study was to evaluate the effect of magnesium supplements on hemodynamic and metabolic parameters in healthy men with a positive family history of MetS or T2DM.
  
  
  RESULTS
  In a randomized, double-blind, placebo-controlled 8-week crossover trial with a 4 week wash-out period, oral supplements of 8.1 mmol of magnesium-pidolate or placebo were administered twice a day to 14 healthy normomagnesemic participants, aged 23-33 years. The primary endpoint was office BP, measured with a semiautomatic oscillometric device. Secondary endpoints included characteristics of the MetS, namely endothelial function, arterial stiffness and inflammation. Plasma and urinary magnesium were measured in all participants while free intracellular magnesium was measured only in a subsample. There was no significant difference in either systolic and diastolic BP in participants post-magnesium supplementation and post-placebo treatment when compared to baseline BP measurements. Further, the metabolic, inflammatory and hemodynamic parameters did not vary significantly during the study.
  
  
  CONCLUSIONS
  Our study showed no beneficial effect of magnesium supplements on BP, vascular function and glycolipid profile in young men with a family history of MetS/T2DM (trial registration at clinicaltrial.gov ID: NCT01181830; 12th of Aug 2010).
authors.affiliation: Department of Medicine, Azienda Ospedaliera Universitaria Integrata of Verona, University of Verona, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Cosaro
authors.affiliation: Department of Medicine, Azienda Ospedaliera Universitaria Integrata of Verona, University of Verona, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Bonafini
authors.affiliation: Department of Life and Reproduction Sciences, Azienda Ospedaliera Universitaria Integrata of Verona, University of Verona, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Montagnana
authors.affiliation: Department of Life and Reproduction Sciences, Azienda Ospedaliera Universitaria Integrata of Verona, University of Verona, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Danese
authors.affiliation: Department of Medicine, Azienda Ospedaliera Universitaria Integrata of Verona, University of Verona, Italy.
authors.forename: M S
authors.initials: MS
authors.lastname: Trettene
authors.affiliation: Department of Medicine, Azienda Ospedaliera Universitaria Integrata of Verona, University of Verona, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Minuz
authors.affiliation: Department of Medicine, Azienda Ospedaliera Universitaria Integrata of Verona, University of Verona, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Delva
authors.affiliation: Department of Medicine, Azienda Ospedaliera Universitaria Integrata of Verona, University of Verona, Italy. Electronic address: cristiano.fava@med.lu.se.
authors.forename: C
authors.initials: C
authors.lastname: Fava
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D018592:Cross-Over Studies; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism; D023381:Endpoint Determination; D064368:Healthy Volunteers; D006801:Humans; D006973:Hypertension / Q000378:metabolism; D008274:Magnesium / Q000008:administration & dosage*; D008297:Male; D024821:Metabolic Syndrome / Q000378:metabolism*; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D059289:Vascular Stiffness; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D008274:Magnesium
keywords: Arterial stiffness; Blood pressure; Diabetes; Flow mediated dilatation; Magnesium; Metabolic syndrome; Positive family history