title: Improvement in symptoms of the syndrome of mitochondrial encephalopathy, lactic acidosis, and stroke-like symptoms (MELAS) following treatment with sympathomimetic amines--possible implications for improving fecundity in women of advanced reproductive age.
abstract: OBJECTIVE
  To evaluate the efficacy of sympathomimetic amine therapy on a mitochondrial abnormality known as the mitochondrial encephalopathy lactic acidosis and stroke-like symptoms syndrome (MELAS syndrome).
  
  
  METHODS
  Dextroamphetamine sulfate 15 mg extended release capsule was prescribed to a woman with a 25 year history of MELAS syndrome refractory to most other therapies.
  
  
  RESULTS
  Within one month of therapy the woman noticed considerable improvement in her chronic fatigue, pain, and edema.
  
  
  CONCLUSIONS
  The MELAS syndrome is thus another condition to add to the list of various chronic refractory disorders that improve considerably after dextroamphetamine therapy. This is the first mitochondrial disorder shown to improve with sympathomimetic amines which could suggest that dextroamphetamine could prove useful in decreasing the risk of aneuploidy in women of advanced reproductive age.
authors.forename: C P
authors.initials: CP
authors.lastname: Potestio
authors.forename: J H
authors.initials: JH
authors.lastname: Check
authors.forename: J
authors.initials: J
authors.lastname: Mitchell-Williams
mesh_terms: D000328:Adult; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D059350:Chronic Pain / Q000188:drug therapy / Q000209:etiology; D003913:Dextroamphetamine / Q000627:therapeutic use*; D004487:Edema / Q000188:drug therapy / Q000209:etiology; D015673:Fatigue Syndrome, Chronic / Q000188:drug therapy / Q000209:etiology; D005260:Female; D006801:Humans; D017241:MELAS Syndrome / Q000150:complications / Q000188:drug therapy*; D008875:Middle Aged
chemical_list: D000697:Central Nervous System Stimulants; D003913:Dextroamphetamine