title: DNA interaction and photocleavage properties of Ru (II) complexes [Ru(bpy)₂(pibi)]²⁺ and [Ru(phen)₂(pibi)]²⁺.
abstract: A new asymmetry ligand pibi (pibi = 2-(pyridine-2-yl)-1-H-imidazo[4,5-f]benzo[d]imidazolone) and its ruthenium complexes with [Ru(L)2(pibi)](2+) (L = bpy (2, 2'-bipyridine), phen (1, 10-phenanthroline)), have been synthesized and characterized. The binding of two complexes with calf thymus DNA has been investigated by spectroscopic and viscosity measurement. The results indicate that both complexes can bind to CT-DNA through intercalative mode. Under irradiation at 365 nm, both complexes can partly promote the photocleavage of plasmid pBR322DNA. The low singlet oxygen generation abilities of the two complexes may be the factor for the low DNA photocleavage abilities.
authors.affiliation: a College of Chemistry and Chemical Engineering , Hunan University of Arts and Science , ChangDe , P.R. China.
authors.forename: XueWen
authors.initials: X
authors.lastname: Liu
authors.forename: ZhiXin
authors.initials: Z
authors.lastname: Li
authors.forename: Xia
authors.initials: X
authors.lastname: Hu
authors.forename: SongBai
authors.initials: S
authors.lastname: Zhang
authors.forename: JiLin
authors.initials: J
authors.lastname: Lu
mesh_terms: D000818:Animals; D001667:Binding, Competitive; D002417:Cattle; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*; D055668:Photochemical Processes; D012428:Ruthenium / Q000737:chemistry*; D026082:Singlet Oxygen / Q000737:chemistry; D014783:Viscosity
chemical_list: D009942:Organometallic Compounds; D026082:Singlet Oxygen; D012428:Ruthenium; D004247:DNA; C427203:calf thymus DNA
keywords: Asymmetric ligand; DNA-binding; Photocleavage; Ru(II) complex; Singlet oxygen