title: Transient decrease in human peripheral blood myeloid dendritic cells following influenza vaccination correlates with induction of serum antibody.
abstract: Dendritic cells (DC) are critical inducers of the adaptive immune response. Extensive characterization of tissue-resident and monocyte-derived DC has revealed diverse stimulatory and regulatory actions, although the role of peripheral blood dendritic cells (PBDC) in maintaining homeostasis remains unclear. Examination of various myeloid (CD11c+CD303-) and plasmacytoid (CD11c-CD303+) DC populations in the peripheral blood of seasonal trivalent inactivated influenza vaccine recipients revealed a transient decrease in the frequency of CD11c+CD1c- myeloid DC subsets 5-10 days following vaccination, including both CD141+ and CD141- myeloid DC subsets of this population. These populations rebounded by 1 month, while plasmacytoid DC remained stable. The magnitude of the decrease in the CD141+ myeloid DC subset at d5-7 significantly correlated with the induction of influenza specific serum antibodies measured at 1 month following vaccination. These results demonstrate a mobilization of peripheral blood myeloid DC following vaccination and indicate these cells are potential biomarkers of immune response.
authors.affiliation: Infectious Diseases Division, University of Rochester Medical Center , Rochester NY 14642 , USA and.
authors.forename: James J
authors.initials: JJ
authors.lastname: Kobie
authors.forename: John J
authors.initials: JJ
authors.lastname: Treanor
authors.forename: Christopher T
authors.initials: CT
authors.lastname: Ritchlin
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D015703:Antigens, CD / Q000378:metabolism; D001773:Blood Cells / Q000276:immunology*; D002452:Cell Count; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D007252:Influenza Vaccines; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control*; D022423:Myeloid Cells / Q000276:immunology*; D014611:Vaccination
chemical_list: D000914:Antibodies, Viral; D015703:Antigens, CD; D007252:Influenza Vaccines
keywords: Antibody; blood; dendritic cell; human; influenza; vaccine