title: Enhancement of radiosensitization by metal-based nanoparticles in cancer radiation therapy.
abstract: Radiation therapy performs an important function in cancer treatment. However, resistance of tumor cells to radiation therapy still remains a serious concern, so the study of radiosensitizers has emerged as a persistent hotspot in radiation oncology. Along with the rapid advancement of nanotechnology in recent years, the potential value of nanoparticles as novel radiosensitizers has been discovered. This review summarizes the latest experimental findings both in vitro and in vivo and attempts to highlight the underlying mechanisms of response in nanoparticle radiosensitization.
authors.affiliation: 1 Department of Oncology, Zhongda Hospital of Southeast University, Nanjing 210009, China ; 2 Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210009, China.
authors.forename: Xiang-Yu
authors.initials: XY
authors.lastname: Su
authors.affiliation: 1 Department of Oncology, Zhongda Hospital of Southeast University, Nanjing 210009, China ; 2 Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210009, China.
authors.forename: Pei-Dang
authors.initials: PD
authors.lastname: Liu
authors.affiliation: 1 Department of Oncology, Zhongda Hospital of Southeast University, Nanjing 210009, China ; 2 Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210009, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
authors.affiliation: 1 Department of Oncology, Zhongda Hospital of Southeast University, Nanjing 210009, China ; 2 Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210009, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Gu
keywords: Nanoparticles; cancer; radiation tolerance; radiotherapy