title: Comparison of serum oxidant and antioxidant parameters in familial Mediterranean fever patients (FMF) with attack free period.
abstract: OBJECTIVE
  Familial Mediterranean fever (FMF) is an autoinflammatory, autosomal recessive, inherited disease characterized by recurrent self-limiting attacks of serosal surfaces. The imbalance of oxidants/antioxidants may play a role in such attacks. In this study, we aimed to evaluate the relationship between serum paraoxonase (PON1) activity, PON1 phenotype, and other parameters in patients with FMF and healthy controls.
  
  
  METHODS
  A total of 120 FMF patients with an attack-free period (AFP) and 65 healthy subjects were included in this study. The serum PON1 activity, stimulated paraoxonase (SPON) activity, PON1 phenotype (representing Q192R polymorphism; QQ, QR, RR), arylesterase activity, total oxidant status (TOS), total antioxidant capacity (TAC), oxidative stress index (OSI), advanced oxidative protein products (AOPP), total thiols (TTL), and ischemia-modified albumin (IMA) and cystatin-c (CYS-C) levels were measured.
  
  
  RESULTS
  For the QQ phenotype, the median TTL and AOPP levels of the control group were 264.50 (57.75) mol/L and 21.26 (21.17) mmol/L, respectively, whereas the median TTL, AOPP levels of the patients were 309.00 (47.00) mol/L and 12.98 (6.96) mmol/L, respectively. There was a statistically significant difference between the patients and controls with the QQ phenotype in terms of TTL and AOPP (p< 0.001 and p= 0.004, respectively). However, there were no statistically significant differences between the QQ and QR+RR phenotypes with respect to TAC, TOS, OSI, or the other parameters.
  
  
  CONCLUSIONS
  The FMF patients with AFP had higher TTL and lower AOPP levels than the controls. However, other oxidant and antioxidant parameters were similar among the patients during AFP and the controls.
authors.affiliation: Cumhuriyet University, Medical Faculty, Sivas.
authors.forename: Ali
authors.initials: A
authors.lastname: Şahin
authors.affiliation: Yıldırım Beyazıt University, Atatürk Education and Research Hospital, Ankara.
authors.forename: Şükran
authors.initials: Ş
authors.lastname: Erten
authors.affiliation: Atatürk Education and Research Hospital, Ankara.
authors.forename: Alpaslan
authors.initials: A
authors.lastname: Altunoğlu
authors.affiliation: Atatürk Education and Research Hospital, Ankara.
authors.forename: Semra
authors.initials: S
authors.lastname: Işıkoğlu
authors.affiliation: Atatürk Education and Research Hospital, Ankara.
authors.forename: Salim
authors.initials: S
authors.lastname: Neşelioğlu
authors.affiliation: Atatürk Education and Research Hospital, Ankara.
authors.forename: Merve
authors.initials: M
authors.lastname: Ergin
authors.affiliation: Atatürk Education and Research Hospital, Ankara.
authors.forename: Hacı Veli
authors.initials: HV
authors.lastname: Atalay
authors.affiliation: Yıldırım Beyazıt University, Atatürk Education and Research Hospital, Ankara.
authors.forename: Özcan
authors.initials: Ö
authors.lastname: Erel
mesh_terms: D000975:Antioxidants / Q000032:analysis*; D043303:Aryldialkylphosphatase / Q000097:blood*; D002265:Carboxylic Ester Hydrolases / Q000097:blood*; D055316:Cystatin C / Q000097:blood*; D010505:Familial Mediterranean Fever / Q000097:blood* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D016877:Oxidants / Q000097:blood*
chemical_list: D000975:Antioxidants; D055316:Cystatin C; D016877:Oxidants; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase