title: Long-term outcome of an intravitreal dexamethasone implant for the treatment of noninfectious uveitic macular edema.
abstract: OBJECTIVE
  To report the long-term outcome of an intravitreal dexamethasone drug delivery system (DEX-DDS) injection for noninfectious uveitic macular edema.
  
  
  METHODS
  This was a retrospective study of 8 eyes (7 patients).
  
  
  RESULTS
  The mean follow-up time was 17.3 months. Macular edema resolved in all eyes at 3.9 weeks (range 1-6.9) postinjection. The central point thickness improved from 612 ± 143 to 250 ± 55 µm (p < 0.05). The mean best corrected visual acuity improved by 0.25 logMAR (p < 0.05) at 3.9 weeks (range 1-6.9) postinjection. In 5 eyes, macular edema did not recur after a mean follow-up of 14.5 months. In 3 eyes, macular edema relapsed after 4.7 months (range 3.6-6.3) and resolved again following further injections. Two eyes developed intraocular pressure elevation, which was well controlled with topical treatment.
  
  
  CONCLUSIONS
  Intravitreal DEX-DDS injections resulted in resolution of macular edema and visual acuity improvement. Some eyes required repeated injections, but most eyes achieved long-term resolution. No significant complications were noticed.
authors.affiliation: Department of Ophthalmology, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Zohar
authors.initials: Z
authors.lastname: Habot-Wilner
authors.forename: Nir
authors.initials: N
authors.lastname: Sorkin
authors.forename: Dafna
authors.initials: D
authors.lastname: Goldenberg
authors.forename: Anat
authors.initials: A
authors.lastname: Loewenstein
authors.forename: Michaella
authors.initials: M
authors.lastname: Goldstein
mesh_terms: D000328:Adult; D003907:Dexamethasone / Q000008:administration & dosage*; D004343:Drug Implants; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D058449:Intravitreal Injections; D008269:Macular Edema / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D014605:Uveitis / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D014792:Visual Acuity / Q000187:drug effects; D014822:Vitreous Body / Q000187:drug effects; D055815:Young Adult
chemical_list: D004343:Drug Implants; D005938:Glucocorticoids; D003907:Dexamethasone