title: Predictive value of brachial-ankle pulse wave velocity for long-term clinical outcomes after percutaneous coronary intervention in a Korean cohort.
abstract: OBJECTIVE
  The aim of this study was to determine the associations of brachial-ankle pulse wave velocity (baPWV), high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B type natriuretic peptide (NT-proBNP) with the development of adverse outcomes after percutaneous coronary intervention (PCI).
  
  
  METHODS
  The baPWV, hs-cTnT and NT-proBNP were analyzed in 372 patients who underwent PCI. The primary endpoint was cardiac death.
  
  
  RESULTS
  There were 21 events of cardiac death during a mean of 25.8 months of follow-up. When the baPWV cut-off level was set to 1672 cm/s using the receiver operating characteristic curve, the sensitivity was 85.7% and the specificity was 60.1% for differentiating between the group with cardiac death and the group without cardiac death. Kaplan-Meier analysis revealed that the higher baPWV group (≥1672 cm/s) had a significantly higher cardiac death rate than the lower baPWV group (<1672 cm/s) (11.4% vs. 1.4%, log-rank: P<0.0001). This value was more useful in patients with myocardial injury (hs-cTnT≥0.1 ng/mL) or heart failure (NT-proBNP≥450 pg/mL).
  
  
  CONCLUSIONS
  The results of this study show that high baPWV is a predictive marker for cardiac death after PCI.
authors.affiliation: Department of Internal Medicine, Chosun University School of Medicine, Gwangju 501-759, Republic of Korea.
authors.forename: Young-Jae
authors.initials: YJ
authors.lastname: Ki
authors.affiliation: Department of Internal Medicine, Chosun University School of Medicine, Gwangju 501-759, Republic of Korea. Electronic address: dhchoi@chosun.ac.kr.
authors.forename: Dong-Hyun
authors.initials: DH
authors.lastname: Choi
authors.affiliation: Department of Internal Medicine, Chosun University School of Medicine, Gwangju 501-759, Republic of Korea.
authors.forename: Young-Min
authors.initials: YM
authors.lastname: Lee
authors.affiliation: Department of Biomaterials, Chosun University Graduate School, Gwangju 501-759, Republic of Korea.
authors.forename: Leejin
authors.initials: L
authors.lastname: Lim
authors.affiliation: Department of Biochemistry and Molecular Biology, Chosun University School of Medicine, Gwangju 501-759, Republic of Korea.
authors.forename: Heesang
authors.initials: H
authors.lastname: Song
authors.affiliation: Department of Internal Medicine, Chosun University School of Medicine, Gwangju 501-759, Republic of Korea.
authors.forename: Young-Youp
authors.initials: YY
authors.lastname: Koh
mesh_terms: D000368:Aged; D055109:Ankle Brachial Index / Q000401:mortality* / Q000639:trends*; D001783:Blood Flow Velocity / Q000502:physiology; D003643:Death; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000401:mortality* / Q000639:trends*; D011237:Predictive Value of Tests; D011673:Pulsatile Flow / Q000502:physiology*; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome
keywords: Cardiac death; N-terminal pro-BNP; Percutaneous coronary intervention; Troponin T; baPWV