title: Has the percutaneous vertebroplasty a role to prevent progression or local recurrence in spinal metastases of breast cancer?
abstract: OBJECTIVE
  To evaluate the effectiveness of percutaneous vertebroplasty (PV) on the prevention of progression or local recurrence in patients with spinal metastases from breast cancer.
  
  
  METHODS
  Retrospective study on 55 patients between 27-78 years of age (mean age: 55 years) treated for metastatic breast cancer in the same institution (Curie institute, Paris, France), who underwent percutaneous vertebroplasty (PV) (number of vertebrae treated=137) for spinal metastases from January 2000 to December 2009 at the Pitié-Salpêtrière hospital. Statistical correlation between the local tumor progression/recurrence, and the presence of an epidural or a paravertebral metastatic extension at diagnosis, the rate of cement filling the lesion (<50%, ≥50% but incomplete, complete/almost complete) and radiotherapy was evaluated using Chi(2) and Fisher's exact test.
  
  
  RESULTS
  The rate of local tumor progression/recurrence of the vertebrae treated by vertebroplasty was 14% (19/137). No statistically significant correlation between either the rate of cement filling of the lesion, or the presence of an epidural or paravertebral metastatic extension, and progression/local recurrence after vertebroplasty was found. No influence of radiotherapy in preventing local progression/recurrence was noted. Distant new bone metastases were observed in 47 out of 55 patients (86%).
  
  
  CONCLUSIONS
  The low rate of local tumor progression/recurrence after a vertebroplasty may support the hypothesis of an antitumor effect of the cement.
authors.affiliation: Department of Neuroradiology, Pitié-Salpêtrière hospital, Paris VI University, 47, boulevard de l'Hôpital, 75013 Paris, France.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Roedel
authors.affiliation: Department of Neuroradiology, Pitié-Salpêtrière hospital, Paris VI University, 47, boulevard de l'Hôpital, 75013 Paris, France. Electronic address: fredclare5@msn.com.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Clarençon
authors.affiliation: Department of Radiology, Institut Curie, Paris, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Touraine
authors.affiliation: Department of Neuroradiology, Pitié-Salpêtrière hospital, Paris VI University, 47, boulevard de l'Hôpital, 75013 Paris, France.
authors.forename: Evelyne
authors.initials: E
authors.lastname: Cormier
authors.affiliation: Department of Neuroradiology, Pitié-Salpêtrière hospital, Paris VI University, 47, boulevard de l'Hôpital, 75013 Paris, France.
authors.forename: Luc
authors.initials: L
authors.lastname: Molet-Benhamou
authors.affiliation: Department of anesthesiology, Pitié-Salpêtrière hospital, Paris, France.
authors.forename: Lise
authors.initials: L
authors.lastname: Le Jean
authors.affiliation: Department of Radiology, Institut Curie, Paris, France.
authors.forename: Hervé
authors.initials: H
authors.lastname: Brisse
authors.affiliation: Department of Radiology, Institut Curie, Paris, France.
authors.forename: Sylvia
authors.initials: S
authors.lastname: Neuenschwander
authors.affiliation: Department of Neuroradiology, Pitié-Salpêtrière hospital, Paris VI University, 47, boulevard de l'Hôpital, 75013 Paris, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Chiras
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000517:prevention & control*; D012189:Retrospective Studies; D013125:Spinal Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy*; D016896:Treatment Outcome; D054854:Vertebroplasty / Q000379:methods*
keywords: Antitumor effect; Breast cancer; Metastasis; Percutaneous vertebroplasty; Progression; Recurrence