title: Changes of serum omentin-1 levels in normal subjects, type 2 diabetes and type 2 diabetes with overweight and obesity in Chinese adults.
abstract: OBJECTIVE
  Omentin-1 has been identified as interesting novel adipokines that may modulate insulin action. Its exact biological function is unclear. The aim of this study is to assay the levels of serum omentin-1 in normal subjects and type 2 diabetes mellitus (T2DM) with normal weight, overweight and obesity and to analyze the relationship between serum omentin-1 levels with body mass index (BMI), waist to hip ratio (WHR), glycosylated hemoglobin (HbA1c), plasma glucose, insulin resistance index (HOMA-IR) and serum lipid levels.
  
  
  METHODS
  There are eighty newly diagnosed type 2 diabetes patients, thirty-five type 2 diabetes patients with normal weight, twenty-nine type 2 diabetes patients with overweight, sixteen type 2 diabetes patients with obesity, and forty healthy control subjects were enrolled in this study. The levels of plasma glucose at fasting and 2-hour postprandial blood glucose and fasting serum levels of insulin, omentin-1and HbA1c were measured. HOMA-IR was calculated.
  
  
  RESULTS
  Serum omentin-1 levels were found to be significantly decreased in type 2 diabetes patients with normal weight (821.16 ± 312.50 ng/L), in type 2 diabetes patients with overweight (748.00±322.51 ng/L), and in type 2 diabetes patients with obesity (530.44±357.35 ng/L) compared with healthy control subjects (994.71±435.90 ng/L) at P<0.05. The level of serum omentin-1 was negatively correlated to BMI, HOMA-IR, WHR, fasting insulin (FINS), fasting plasma glucose (FPG), 2-hour postprandial blood glucose (2HPG), triglycerides (TG), and positively correlated to high-density lipoprotein (HDL). BMI was independent related factor that influenced the levels of serum omentin-1.
  
  
  CONCLUSIONS
  Decreased omentin-1 levels may contribute to the development of insulin resistance, T2DM and particularly to obesity in Chinese adults, however, its role in these diseases needs to be fully elucidated.
authors.affiliation: Department of Endocrinology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, 110, Ganhe Road, 200437 Hongkou District, Shanghai, People's Republic of China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: The Pingliang Community Health Center of Yangpu District, 335, Pingliang Road, 200082 Yangpu District, Shanghai, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Department of Endocrinology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, 110, Ganhe Road, 200437 Hongkou District, Shanghai, People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Zheng
authors.affiliation: Department of Endocrinology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, 110, Ganhe Road, 200437 Hongkou District, Shanghai, People's Republic of China.
authors.forename: Chaohua
authors.initials: C
authors.lastname: Fan
authors.affiliation: Department of Endocrinology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, 110, Ganhe Road, 200437 Hongkou District, Shanghai, People's Republic of China.
authors.forename: Yunhao
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Endocrinology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, 110, Ganhe Road, 200437 Hongkou District, Shanghai, People's Republic of China.
authors.forename: Dan
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, 110, Ganhe Road, 200437 Hongkou District, Shanghai, People's Republic of China.
authors.forename: Yanming
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Endocrinology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, 110, Ganhe Road, 200437 Hongkou District, Shanghai, People's Republic of China. Electronic address: yanghongjie1088@sina.cn.
authors.forename: Hongjie
authors.initials: H
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose; D015992:Body Mass Index; D002681:China; D008076:Cholesterol, HDL / Q000097:blood; D016207:Cytokines / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D006442:Glycated Hemoglobin; D006801:Humans; D007333:Insulin Resistance; D037102:Lectins / Q000097:blood*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000150:complications; D050177:Overweight / Q000097:blood* / Q000150:complications; D049629:Waist-Hip Ratio
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D016207:Cytokines; D058851:GPI-Linked Proteins; D006442:Glycated Hemoglobin; D037102:Lectins; D008055:Lipids; C432397:ITLN1 protein, human
keywords: Adipokines; Insulin and diabetes; Insuline et diabète; Omentin; Omentine