title: Ameliorative effect of Elaeocarpus ganitrus on gentamicin-induced nephrotoxicity in rats.
abstract: OBJECTIVE
  The present study was designed to evaluate the ameliorative effect of Elaeocarpus ganitrus on gentamicin (GM)-induced nephrotoxicity in rats.
  
  
  METHODS
  E. ganitrus (100, 200, and 400 mg/kg body weight) was administered orally to male Wistar rats. GM (100 mg/kg) was used to induce nephrotoxicity. Study parameters include serum albumin, creatinine, blood urea nitrogen (BUN), uric acid, creatinine, and albuminuria. Total protein in serum, antioxidant enzymes activities, phagocytic index, and neutrophil adhesion assays were performed to determine oxidative stress and immunomodulatory action of E. ganitrus.
  
  
  RESULTS
  The results revealed that coadministration of E. ganitrus significantly reduced the elevated level of serum creatinine, BUN, uric acid, and albuminuria with considerable increase in the serum albumin and urine creatinine. Furthermore, E. ganitrus noticeably increased serum total protein and antioxidant enzyme levels with significant alteration in phagocytic index and neutrophil adhesion assay when compared with GM-treated group in a dose-dependent manner.
  
  
  CONCLUSIONS
  The present study revealed that ethanolic extract of E. ganitrus seeds has immunomodulatory and nephroprotective activity.
authors.affiliation: Department of Pharmacology, School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Rangareddy, Hyderabad, Andhra Pradesh, India.
authors.forename: Rahul Motiram
authors.initials: RM
authors.lastname: Kakalij
authors.affiliation: Department of Pharmacology, School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Rangareddy, Hyderabad, Andhra Pradesh, India.
authors.forename: Chaitanya P
authors.initials: CP
authors.lastname: Alla
authors.affiliation: Department of Pharmacology, School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Rangareddy, Hyderabad, Andhra Pradesh, India.
authors.forename: Rahul P
authors.initials: RP
authors.lastname: Kshirsagar
authors.affiliation: Department of Pharmacology, School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Rangareddy, Hyderabad, Andhra Pradesh, India.
authors.forename: Boyina Hemanth
authors.initials: BH
authors.lastname: Kumar
authors.affiliation: Department of Pharmacology, School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Rangareddy, Hyderabad, Andhra Pradesh, India.
authors.forename: Sumeet S
authors.initials: SS
authors.lastname: Mutha
authors.affiliation: Department of Pharmacology, School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Rangareddy, Hyderabad, Andhra Pradesh, India.
authors.forename: Prakash Vamanrao
authors.initials: PV
authors.lastname: Diwan
mesh_terms: D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D001806:Blood Urea Nitrogen; D002374:Catalase / Q000378:metabolism; D002448:Cell Adhesion / Q000187:drug effects; D003404:Creatinine / Q000097:blood / Q000652:urine; D045467:Elaeocarpaceae; D005839:Gentamicins; D005978:Glutathione / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D007677:Kidney Function Tests; D008297:Male; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology; D010587:Phagocytosis / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D017208:Rats, Wistar; D012639:Seeds; D013482:Superoxide Dismutase / Q000378:metabolism; D014527:Uric Acid / Q000097:blood
chemical_list: D001798:Blood Proteins; D005839:Gentamicins; D010936:Plant Extracts; D020011:Protective Agents; D014527:Uric Acid; D003404:Creatinine; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione
keywords: Elaeocarpus ganitrus; gentamicin; immunomodulatory; nephroprotective