title: No correlation between serotonin and its metabolite 5-HIAA in the cerebrospinal fluid and [(11) C]AZ10419369 binding measured with PET in healthy volunteers.
abstract: [(11) C]AZ10419369 is sensitive to pharmacologically enhanced endogenous serotonin levels. Twelve healthy volunteers underwent [(11) C]AZ10419369 PET and lumbar puncture. There were no correlations between [(11) C]AZ10419369 binding and concentrations of serotonin and its metabolite 5-HIAA in cerebrospinal fluid, suggesting that [(11) C]AZ10419369 brain binding does not reflect baseline serotonin levels in cerebrospinal fluid.
authors.affiliation: Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden.
authors.forename: Mikael
authors.initials: M
authors.lastname: Tiger
authors.forename: Per
authors.initials: P
authors.lastname: Svenningsson
authors.forename: Magdalena
authors.initials: M
authors.lastname: Nord
authors.forename: Sandra
authors.initials: S
authors.lastname: Jabre
authors.forename: Christer
authors.initials: C
authors.lastname: Halldin
authors.forename: Johan
authors.initials: J
authors.lastname: Lundberg
mesh_terms: D000328:Adult; D001578:Benzopyrans; D001921:Brain / Q000000981:diagnostic imaging*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D009025:Morpholines; D010865:Pilot Projects; D010879:Piperazines; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D012701:Serotonin / Q000134:cerebrospinal fluid*; D013129:Spinal Puncture; D055815:Young Adult
chemical_list: C530629:5-methyl-8-(4-methyl-piperazin-1-yl)-4-oxo-4H-chromene-2-carboxylic acid (4-morpholin-4-yl-phenyl)amide; D001578:Benzopyrans; D009025:Morpholines; D010879:Piperazines; D019275:Radiopharmaceuticals; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid
keywords: 5-HT1B receptors; autoreceptor; displacement; sensitivity