title: Non-invasive fibrosis tests are correlated with necroinflammatory actvity of liver in patients with chronic hepatitis B.
abstract: BACKGROUND
  The gold standarda method used for assessing necroinflammatory activity and fibrosis in the liver is a liver biopsy which has many disadvantages. Therefore, many investigators have been trying to develop non-invasive tests for predicting liver fibrosis score (LFS) of these patients. The aim of this study is to describe the relationship between certain non-invasive fibrosis markers with LFS and histological activity index (HAI) detected histopathologically by liver biopsy in chronic hepatitis B patients.
  
  
  METHODS
  A total of 54 patients who had undergone a liver biopsy with the diagnosis of chronic HBV infection were included in the study. Ishak scoring was used for the evaluation of liver fibrosis, and a modified Knodell HAI was used for demonstration of necroinflammation. In this study, non-invasive fibrosis tests were calculated as described in previous studies.
  
  
  RESULTS
  Histological acitivity index was positively correlated with age, age/platelet index, cirrhosis discriminant score (CDS), AST/platelet ratio index (APRI), AST/platelet/GGT/AFP index (APGA), fibro-quotient (Fibro-Q), Goteburg University Cirrhosis Index (Guci), and Platelet/Age/Phosphatase/AFP/AST index (PAPAS). When divided into two groups according to HAI, Guci and APGA were found significantly different both in >4 and >4 HAI groups than the other group. In ROC analysis performed for LFS; PAPAS, APGA, FFI and APRI were the markers having the highest AUC levels, and in ROC analysis performed for HAI; Guci, APRI and APGA were the markers with the highest AUC levels.
  
  
  CONCLUSIONS
  APRI, APGA and GUCI tests may be helpful in prediction of necroinflammatory scores in the liver.
authors.affiliation: Departments of Pathology, Abant Izzet Baysal University Medical Faculty, Bolu, Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Ozyalvacli
authors.affiliation: Departments of Infectious Diseases, Abant Izzet Baysal University Medical Faculty, Bolu, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Kucukbayrak
authors.affiliation: Departments of Gastroenterology, Abant Izzet Baysal University Medical Faculty, Bolu, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Kurt
authors.affiliation: Departments of Radiology, Abant Izzet Baysal University Medical Faculty, Bolu, Turkey.
authors.forename: K
authors.initials: K
authors.lastname: Gurel
authors.affiliation: Departments of Infectious Diseases, Abant Izzet Baysal University Medical Faculty, Bolu, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Gunes
authors.affiliation: Departments of Infectious Diseases, Abant Izzet Baysal University Medical Faculty, Bolu, Turkey.
authors.forename: C
authors.initials: C
authors.lastname: Ustun
authors.affiliation: Departments of Infectious Diseases, Abant Izzet Baysal University Medical Faculty, Bolu, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Akdeniz
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D001706:Biopsy; D005260:Female; D019694:Hepatitis B, Chronic / Q000473:pathology*; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D012372:ROC Curve; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase