title: Impact of statin usage patterns on outcomes after percutaneous coronary intervention in acute myocardial infarction: Korea Working Group on Myocardial Infarction registry (KorMI) study.
abstract: BACKGROUND
  The benefit of statin use after acute ST-segment elevation myocardial infarction (STEMI) has been well established, however, the influence of the timing of statin administration has not been elucidated. The objective of this study focused on early clinical outcomes after percutaneous coronary intervention (PCI).
  
  
  METHODS
  This analysis of the Korea Working Group on Myocardial Infarction registry (KorMI) study included 3,584 STEMI patients (mean age, 63 ± 13 years; male, 2,684, 74.9%) undergoing PCI from January 2008 to June 2009. Rates of major adverse cardiac events (MACE: all-cause death, recurrent MI, and target lesion revascularization) were compared among patients grouped according to statin therapy timing: I, both during and after hospitalization (n = 2,653, 74%); II, only during hospitalization (n = 309, 8.6%); III, only after discharge (n = 157, 4.4%); and IV, no statin therapy (n = 465, 13%). Mean follow-up duration was 234 ± 113 days.
  
  
  RESULTS
  Multivariate factors of statin use during hospitalization included prior statin use, multiple diseased vessels, final thrombolysis in myocardial infarction flow grade III, and low-density lipoprotein cholesterol level. At 6-month follow-up, groups III and IV had the highest MACE rates (2.3%, 3.9%, 5.1%, and 4.9% for groups I-IV, respectively, P = 0.004). After adjusting for confounders, groups II-IV had a higher MACE risk than group I [hazard ratio (HR): 3.20, 95% confidence interval (95%CI): 1.31-7.86, P = 0.011; HR: 3.84, 95%CI: 1.47-10.02, P = 0.006; and HR: 3.17, 95%CI: 1.59-6.40, P = 0.001; respectively].
  
  
  CONCLUSIONS
  This study, based on the national registry database, shows early and continuous statin therapy improvs early outcomes of STEMI patients after PCI in real-world clinical practice.
authors.affiliation: Department of Cardiology, Yeungnam University Hospital, 170, Hyeonchung-ro, Nam-gu, Daegu, 705-717, South Korea.
authors.forename: Chan-Hee
authors.initials: CH
authors.lastname: Lee
authors.affiliation: Department of Cardiology, Yeungnam University Hospital, 170, Hyeonchung-ro, Nam-gu, Daegu, 705-717, South Korea.
authors.forename: Sang-Hee
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Department of Cardiology, Yeungnam University Hospital, 170, Hyeonchung-ro, Nam-gu, Daegu, 705-717, South Korea.
authors.forename: Jong-Seon
authors.initials: JS
authors.lastname: Park
authors.affiliation: Department of Cardiology, Yeungnam University Hospital, 170, Hyeonchung-ro, Nam-gu, Daegu, 705-717, South Korea.
authors.forename: Young-Jo
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Daegu Catholic University Hospital, 33, Duryugongwon-ro 17-gil, Nam-gu, Daegu, 705-718, South Korea.
authors.forename: Kee-Sik
authors.initials: KS
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Kyungpook National University Hospital, 130, Dongdeok-ro, Jung-gu, Daegu, 700-721, South Korea.
authors.forename: Shung-Chull
authors.initials: SC
authors.lastname: Chae
authors.affiliation: Department of Internal Medicine, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, Seoul, 110-744, South Korea.
authors.forename: Hyo-Soo
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Seoul National University Bundang Hospital, 82, Gumi-ro 173-gil, Bundang-gu, Seongnam, 463-707, South Korea.
authors.forename: Dong-Ju
authors.initials: DJ
authors.lastname: Choi
authors.affiliation: Department of Internal Medicine, Chungbuk National University Hospital, 776, 1sunhwan-ro, Heungdeok-gu, Cheongju, 361-711, South Korea.
authors.forename: Myeong-Chan
authors.initials: MC
authors.lastname: Cho
authors.affiliation: Department of Internal Medicine, Korea University Guro Hospital, 148, Gurodong-ro, Guro-gu, Seoul, 152-703, South Korea.
authors.forename: Seung-Woon
authors.initials: SW
authors.lastname: Rha
authors.affiliation: Department of Internal Medicine, Chonnam National University Hospital, 42, Jebong-ro, Dong-gu, Gwangju, 501-757, South Korea.
authors.forename: Myung-Ho
authors.initials: MH
authors.lastname: Jeong
keywords: Acute myocardial infarction; Statins; Treatment outcome