title: Phase 1 clinical trial on the effect of palatal brushing on denture stomatitis.
abstract: OBJECTIVE
  This study aimed to assess the efficacy of palatal brushing in the treatment of denture stomatitis.
  
  
  METHODS
  After screening 143 individuals with a potential diagnosis of denture stomatitis, 48 patients (mean age: 66.0 ± 11.2 years) were enrolled in a two-center phase 1 clinical trial with a one-group pretest/posttest design. The intervention of interest was manual palatal brushing after each meal and before bedtime. Clinical and microbiologic examinations were performed at baseline and 1 and 3 months after treatment. Additional data were obtained using a validated questionnaire. The primary and secondary outcomes were the remission of denture stomatitis and diminution of Candida colony-forming units (CFUs), respectively. Descriptive and nonparametric statistical tests were conducted to analyze the data.
  
  
  RESULTS
  At the 3-month follow-up, denture stomatitis was completely cured in 10.4% of the participants, and 70.8% of denture wearers showed improvement in the clinical signs of denture stomatitis. There was a significant reduction in the area and severity of the palatal inflammation (P < .0001). The effect size ranged from medium to large (0.34 to 0.54) depending on the classification used for the diagnosis of denture stomatitis. A significant reduction in the number of Candida CFUs isolated from the palatal mucosa and dentures (P ≤ .05) was observed.
  
  
  CONCLUSIONS
  The results of this study suggest that palatal brushing is an effective treatment of denture stomatitis.
authors.forename: Marla
authors.initials: M
authors.lastname: Kabawat
authors.forename: Raphael F
authors.initials: RF
authors.lastname: de Souza
authors.forename: Maurício M
authors.initials: MM
authors.lastname: Badaró
authors.forename: Louis
authors.initials: L
authors.lastname: de Koninck
authors.forename: Jean
authors.initials: J
authors.lastname: Barbeau
authors.forename: Pierre
authors.initials: P
authors.lastname: Rompré
authors.forename: Elham
authors.initials: E
authors.lastname: Emami
mesh_terms: D000368:Aged; D002175:Candida / Q000145:classification / Q000302:isolation & purification; D002176:Candida albicans / Q000302:isolation & purification; D041221:Candida glabrata / Q000302:isolation & purification; D041022:Candida tropicalis / Q000302:isolation & purification; D002180:Candidiasis, Oral / Q000517:prevention & control; D015169:Colony Count, Microbial; D003773:Dental Plaque / Q000382:microbiology; D003820:Denture Cleansers / Q000627:therapeutic use; D003827:Denture, Complete, Upper / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009061:Mouth Mucosa / Q000382:microbiology; D009910:Oral Hygiene / Q000379:methods; D010159:Palate / Q000382:microbiology; D013282:Stomatitis, Denture / Q000145:classification / Q000382:microbiology / Q000517:prevention & control*; D014099:Toothbrushing / Q000295:instrumentation / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D003820:Denture Cleansers