title: Drosophila Myc: A master regulator of cellular performance.
abstract: The identification of the Drosophila homolog of the human MYC oncogene has fostered a series of studies aimed to address its functions in development and cancer biology. Due to its essential roles in many fundamental biological processes it is hard to imagine a molecular mechanism in which MYC function is not required. For this reason, the easily manipulated Drosophila system has greatly helped in the dissection of the genetic and molecular pathways that regulate and are regulated by MYC function. In this review, we focus on studies of MYC in the fruitfly with particular emphasis on metabolism and cell competition, highlighting the contributions of this model system in the last decade to our understanding of MYC's complex biological nature. This article is part of a Special Issue entitled: Myc proteins in cell biology and pathology.
authors.affiliation: Department of "Farmacia e Biotecnologie", University of Bologna, Via Selmi 3, 40126 Bologna, Italy. Electronic address: daniela.grifoni@unibo.it.
authors.forename: Daniela
authors.initials: D
authors.lastname: Grifoni
authors.affiliation: Department of "Bioscienze", University of Milan, Via Celoria 26, 20133 Milan, Italy. Electronic address: paola.bellosta@unimi.it.
authors.forename: Paola
authors.initials: P
authors.lastname: Bellosta
mesh_terms: D000818:Animals; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000235:genetics* / Q000378:metabolism; D049109:Cell Proliferation; D004331:Drosophila melanogaster; D018507:Gene Expression Regulation, Developmental; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics* / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; C499330:MAX protein, human; C079439:MXD1 protein, human; D016271:Proto-Oncogene Proteins c-myc; D012097:Repressor Proteins
keywords: Cancer; Cell competition; Cell growth; MYC; Metabolism