title: Lipid peroxidation, nitric oxide metabolites, and their ratio in a group of subjects with metabolic syndrome.
abstract: Our aim was to evaluate lipid peroxidation, expressed as thiobarbituric acid-reactive substances (TBARS), nitric oxide metabolites (nitrite + nitrate) expressed as NOx, and TBARS/NOx ratio in a group of subjects with metabolic syndrome (MS). In this regard we enrolled 106 subjects with MS defined according to the IDF criteria, subsequently subdivided into diabetic (DMS) and nondiabetic (NDMS) and also into subjects with a low triglycerides/HDL-cholesterol (TG/HDL-C) index or with a high TG/HDL-C index. In the entire group and in the four subgroups of MS subjects we found an increase in TBARS and NOx levels and a decrease in TBARS/NOx ratio in comparison with normal controls. Regarding all these parameters no statistical difference between DMS and NDMS was evident, but a significant increase in NOx was present in subjects with a high TG/HDL-C index in comparison with those with a low index. In MS subjects we also found a negative correlation between TBARS/NO x ratio and TG/HDL-C index. Considering the hyperactivity of the inducible NO synthase in MS, these data confirm the altered redox and inflammatory status that characterizes the MS and suggest a link between lipid peroxidation, inflammation, and insulin resistance, evaluated as TG/HDL-C index.
authors.affiliation: Dipartimento Biomedico di Medicina Interna e Specialistica, Università di Palermo, Via del Vespro 129, 90100 Palermo, Italy.
authors.forename: Gregorio
authors.initials: G
authors.lastname: Caimi
authors.affiliation: Dipartimento Biomedico di Medicina Interna e Specialistica, Università di Palermo, Via del Vespro 129, 90100 Palermo, Italy.
authors.forename: Rosalia
authors.initials: R
authors.lastname: Lo Presti
authors.affiliation: Dipartimento Biomedico di Medicina Interna e Specialistica, Università di Palermo, Via del Vespro 129, 90100 Palermo, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Montana
authors.affiliation: Dipartimento Biomedico di Medicina Interna e Specialistica, Università di Palermo, Via del Vespro 129, 90100 Palermo, Italy.
authors.forename: Davide
authors.identifier: 0000-0002-5346-2829
authors.initials: D
authors.lastname: Noto
authors.affiliation: Dipartimento Biomedico di Medicina Interna e Specialistica, Università di Palermo, Via del Vespro 129, 90100 Palermo, Italy.
authors.forename: Baldassare
authors.initials: B
authors.lastname: Canino
authors.affiliation: Dipartimento Biomedico di Medicina Interna e Specialistica, Università di Palermo, Via del Vespro 129, 90100 Palermo, Italy.
authors.forename: Maurizio R
authors.initials: MR
authors.lastname: Averna
authors.affiliation: Dipartimento Biomedico di Medicina Interna e Specialistica, Università di Palermo, Via del Vespro 129, 90100 Palermo, Italy.
authors.forename: Eugenia
authors.identifier: 0000-0001-5175-5727
authors.initials: E
authors.lastname: Hopps
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008075:Lipoproteins, HDL / Q000378:metabolism; D008297:Male; D024821:Metabolic Syndrome / Q000378:metabolism*; D008875:Middle Aged; D009566:Nitrates / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism*; D009573:Nitrites / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism
chemical_list: C034396:HDL-triglyceride; D008075:Lipoproteins, HDL; D009566:Nitrates; D009573:Nitrites; D017392:Thiobarbituric Acid Reactive Substances; D014280:Triglycerides; D009569:Nitric Oxide