title: Comparison of antibody response to a non-adjuvanted, live canarypox-vectored recombinant rabies vaccine and a killed, adjuvanted rabies vaccine in Eld's deer (Rucervus eldi thamin).
abstract: Captive Eld's deer (Rucervus eldi thamin) were evaluated for the presence of rabies virus-neutralizing antibodies using a rapid fluorescent focus inhibition after vaccination with either a live canarypox-vectored recombinant rabies vaccine or a killed monovalent rabies vaccine. Twelve deer were vaccinated with 1.0 ml of killed, adjuvanted, monovalent rabies vaccine at 5-33 mo of age then annually thereafter, and 14 deer were vaccinated with 1.0 ml nonadjuvanted, live canarypox-vectored rabies vaccine at 3-15 mo of age then annually thereafter. Banked serum was available or collected prospectively from deer at 6 mo and 1 yr after initial vaccination, then collected annually. Rabies virus-neutralizing antibodies considered adequate (>0.5 IU/ml) were present in 20/34 samples vaccinated with canarypox-vectored rabies vaccine and in 12/14 samples vaccinated with killed adjuvanted rabies vaccine. Poor seroconversion was noted in deer less than 6 mo of age vaccinated with the canarypox-vectored rabies vaccine.
authors.forename: Judilee C
authors.initials: JC
authors.lastname: Marrow
authors.forename: Luis R
authors.initials: LR
authors.lastname: Padilla
authors.forename: Lee-Ann C
authors.initials: LA
authors.lastname: Hayek
authors.forename: Mitch
authors.initials: M
authors.lastname: Bush
authors.forename: Suzan
authors.initials: S
authors.lastname: Murray
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D028121:Canarypox virus / Q000502:physiology*; D003670:Deer / Q000097:blood*; D005260:Female; D005822:Genetic Vectors; D008297:Male; D011446:Prospective Studies; D011818:Rabies / Q000517:prevention & control / Q000662:veterinary*; D011819:Rabies Vaccines / Q000276:immunology*; D011820:Rabies virus / Q000235:genetics / Q000276:immunology; D011994:Recombinant Proteins; D014611:Vaccination / Q000379:methods; D014614:Vaccines, Synthetic / Q000235:genetics; D014764:Viral Proteins
chemical_list: D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D011819:Rabies Vaccines; D011994:Recombinant Proteins; D014614:Vaccines, Synthetic; D014764:Viral Proteins