title: Ruthenium complexes as NO donors for vascular relaxation induction.
abstract: Nitric oxide (NO) donors are substances that can release NO. Vascular relaxation induction is among the several functions of NO, and the administration of NO donors is a pharmacological alternative to treat hypertension. This review will focus on the physicochemical description of ruthenium-derived NO donor complexes that release NO via reduction and light stimulation. In particular, we will discuss the complexes synthesized by our research group over the last ten years, and we will focus on the vasodilation and arterial pressure control elicited by these complexes. Soluble guanylyl cyclase (sGC) and potassium channels are the main targets of the NO species released from the inorganic compounds. We will consider the importance of the chemical structure of the ruthenium complexes and their vascular effects.
authors.affiliation: Faculdade de Ciências Integradas do Pontal, Universidade Federal de Uberlândia, Ituiutaba 38304-402, MG, Brazil. renatagalvao@pontal.ufu.br.
authors.forename: Renata Galvão
authors.initials: RG
authors.lastname: de Lima
authors.affiliation: Departamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto 14040-903, SP, Brazil. brunofarmaco@gmail.com.
authors.forename: Bruno Rodrigues
authors.initials: BR
authors.lastname: Silva
authors.affiliation: Departamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto 14040-903, SP, Brazil. silva@usp.br.
authors.forename: Roberto Santana
authors.initials: RS
authors.lastname: da Silva
authors.affiliation: Departamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto 14040-903, SP, Brazil. bendhack@usp.br.
authors.forename: Lusiane Maria
authors.initials: LM
authors.lastname: Bendhack
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001808:Blood Vessels / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism / Q000494:pharmacology; D020030:Nitric Oxide Donors / Q000737:chemistry / Q000494:pharmacology*; D009599:Nitroprusside / Q000378:metabolism / Q000494:pharmacology; D017975:Ruthenium Compounds / Q000737:chemistry / Q000494:pharmacology*; D014664:Vasodilation / Q000187:drug effects* / Q000502:physiology; D014665:Vasodilator Agents / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D020030:Nitric Oxide Donors; D017975:Ruthenium Compounds; D014665:Vasodilator Agents; D009599:Nitroprusside; D009569:Nitric Oxide