title: Outcomes for supra-aortic branch vessel stenting in the treatment of thoracic aortic disease.
abstract: OBJECTIVE
  Endovascular options for the treatment of proximal thoracic and arch disease have evolved over the years. In this manuscript, we review the midterm results of fenestrated compared with chimney configurations for proximal aortic aneurysm disease.
  
  
  METHODS
  We performed an analysis of all patients with chimney grafts or custom fenestrated endografts used for treatment of proximal thoracic aneurysm disease (involving the supra-aortic trunk vessels) presenting to our institution between 2004 and 2013. Patients were identified by retrospective chart review and through the prospective database (National Institutes of Health study number NCT00583050). Details of devices placed, intraoperative details, and measurements from postoperative imaging were included in the analysis. The primary outcomes of interest were long-term freedom from branch stent complications and freedom from proximal endoleak, but we also included perioperative events, in-hospital mortality, and requirement for secondary interventions in our review. The log-rank test (Mantel-Cox) was used to compare survival data. Student t-test (two tailed) and Fisher exact test (two tailed) were used for continuous and categorical data, respectively.
  
  
  RESULTS
  Of 767 patients who underwent thoracic endovascular repair from January 2004 to February 2013, 33 satisfied the inclusion criteria (4%): 18 of 33 noncustom and 15 of 33 custom graft designs. Overall, the rate of technical success was 97%. There were four branch stent-related problems in the follow-up period, one of 15 (7%) in the custom group and three of 18 (17%) in the noncustom group. There were three proximal sealing failures in the immediate postoperative and follow-up period, one of 15 (7%) in the custom group and two of 18 (11%) in the noncustom group. Overall, 10 patients underwent secondary procedures, four of 15 (27%) in the custom group and six of 18 (33%) in the noncustom group.
  
  
  CONCLUSIONS
  Although they are technically feasible, both custom fenestrated endografts and chimney repairs for proximal thoracic disease involving the supra-aortic trunk vessels suffer from failures in intermediate follow-up, with a trend toward better long-term outcomes for custom devices. More work is needed to develop durable devices for this anatomic territory in the future.
authors.affiliation: Department of Vascular and Endovascular Surgery, Cleveland Clinic Foundation, Cleveland, Ohio.
authors.forename: Adrian
authors.initials: A
authors.lastname: O'Callaghan
authors.affiliation: Department of Vascular and Endovascular Surgery, Cleveland Clinic Foundation, Cleveland, Ohio. Electronic address: mastrat@ccf.org.
authors.forename: Tara M
authors.initials: TM
authors.lastname: Mastracci
authors.affiliation: Department of Vascular and Endovascular Surgery, Cleveland Clinic Foundation, Cleveland, Ohio.
authors.forename: Roy K
authors.initials: RK
authors.lastname: Greenberg
authors.affiliation: Department of Vascular and Endovascular Surgery, Cleveland Clinic Foundation, Cleveland, Ohio.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Eagleton
authors.affiliation: Department of Vascular and Endovascular Surgery, Cleveland Clinic Foundation, Cleveland, Ohio.
authors.forename: James
authors.initials: J
authors.lastname: Bena
authors.affiliation: Department of Vascular and Endovascular Surgery, Cleveland Clinic Foundation, Cleveland, Ohio.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kuramochi
mesh_terms: D001013:Aorta, Thoracic / Q000000981:diagnostic imaging / Q000601:surgery*; D017545:Aortic Aneurysm, Thoracic / Q000000981:diagnostic imaging / Q000601:surgery*; D001807:Blood Vessel Prosthesis; D057867:Endoleak / Q000517:prevention & control; D057510:Endovascular Procedures / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D017052:Hospital Mortality / Q000639:trends; D006801:Humans; D008297:Male; D009820:Ohio / Q000453:epidemiology; D011474:Prosthesis Design; D012189:Retrospective Studies; D015607:Stents; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome