title: Cortical Brain Connectivity and B-Type Natriuretic Peptide in Patients With Congestive Heart Failure.
abstract: The brain has a high level of complexity and needs continuous oxygen supply. So it is clear that any pathological condition, or physiological (aging) change, in the cardiovascular system affects functioning of the central nervous system. We evaluated linear aspects of the relationship between the slowness of cortical rhythms, as revealed by the modulation of a graph connectivity parameter, and congestive heart failure (CHF), as a reflection of neurodegenerative processes. Eyes-closed resting electroencephalographic (EEG) data of 10 patients with CHF were recorded by 19 electrodes positioned according the international 10-20 system. Graph theory function (normalized characteristic path length λ) was applied to the undirected and weighted networks obtained by lagged linear coherence evaluated by eLORETA software, therefore getting rid of volumetric propagation influences. The EEG frequency bands of interest were: delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10.5 Hz), alpha 2 (10.5-13 Hz), beta 1 (13-20 Hz), beta 2 (20-30 Hz), and gamma (30-40 Hz). The analysis between B-type natriuretic peptide (BNP) values and λ showed positive correlation in delta, associated with a negative correlation in alpha 2 band. Namely, the higher the severity of the disease (as revealed by the BNP vales), the higher the λ in delta, and lower in alpha 2 band. Results suggest that delta and alpha λ indices are good markers of the severity of CHF.
authors.affiliation: Brain Connectivity laboratory, IRCCS San Raffaele Pisana, Rome, Italy fabrizio.vecchio@sanraffaele.it.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Vecchio
authors.affiliation: Brain Connectivity laboratory, IRCCS San Raffaele Pisana, Rome, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Miraglia
authors.affiliation: Casa di cura San Raffaele Montecompatri e Rocca di Papa, Rome, Italy.
authors.forename: Lavinia
authors.initials: L
authors.lastname: Valeriani
authors.affiliation: Dip. Emergenza DEA, Sapienza University, Rome, Italy.
authors.forename: Maria Gabriella
authors.initials: MG
authors.lastname: Scarpellini
authors.affiliation: IRCCS Centro Neurolesi Bonino-Pulejo, Messina, Italy.
authors.forename: Placido
authors.initials: P
authors.lastname: Bramanti
authors.affiliation: Dept Neurology and Psichiatry, Sapienza University, Rome, Italy.
authors.forename: Oriano
authors.initials: O
authors.lastname: Mecarelli
authors.affiliation: Brain Connectivity laboratory, IRCCS San Raffaele Pisana, Rome, Italy Dept of Neurology, Catholic University "Sacro Cuore" Rome, Italy.
authors.forename: Paolo M
authors.initials: PM
authors.lastname: Rossini
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000513:Alpha Rhythm; D015415:Biomarkers / Q000097:blood*; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology*; D003700:Delta Rhythm; D004569:Electroencephalography / Q000379:methods; D005260:Female; D006333:Heart Failure / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000503:physiopathology; D009434:Neural Pathways / Q000503:physiopathology; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers
keywords: B-type natriuretic peptide; characteristic path length; congestive heart failure; connectivity and graph theory; electroencephalography