title: Diphenyl diselenide-supplemented diet and swimming exercise enhance novel object recognition memory in old rats.
abstract: The benefits of exercise and the element selenium on mental health and cognitive performance are well documented. The purpose of the present study was to investigate whether the intake of a diet supplemented with diphenyl diselenide [(PhSe)2] and the swimming exercise could enhance memory in old Wistar rats. Male Wistar rats (24 months) were fed daily with standard diet chow or standard chow supplemented with 1 ppm of (PhSe)2 during 4 weeks. Animals were submitted to swimming training with a workload (3 % of body weight, 20 min/day for 4 weeks). After 4 weeks, the object recognition test (ORT) and the object location test (OLT) were performed. The results of this study demonstrated that intake of a supplemented diet with (PhSe)2 and swimming exercise was effective in improving short-term and long-term memory as well as spatial learning, increasing the hippocampal levels of phosphorylated cAMP-response element-binding protein (CREB) in old rats. This study also provided evidence that (PhSe)2-supplemented diet facilitated memory of old rats by modulating cAMP levels and stimulating CREB phosphorylation, without altering the levels of Akt.
authors.affiliation: Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, 97105-900, Brazil.
authors.forename: José L
authors.initials: JL
authors.lastname: Cechella
authors.forename: Marlon R
authors.initials: MR
authors.lastname: Leite
authors.forename: Alisson R
authors.initials: AR
authors.lastname: Rosario
authors.forename: Tuane B
authors.initials: TB
authors.lastname: Sampaio
authors.forename: Gilson
authors.initials: G
authors.lastname: Zeni
mesh_terms: D000375:Aging; D000818:Animals; D003072:Cognition Disorders / Q000503:physiopathology / Q000517:prevention & control*; D019587:Dietary Supplements; D004195:Disease Models, Animal; D004220:Disulfides / Q000494:pharmacology*; D005081:Exercise Therapy / Q000379:methods*; D008297:Male; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D005082:Physical Exertion / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013550:Swimming / Q000502:physiology*
chemical_list: D004220:Disulfides; C053871:diphenyl disulfide