title: Effect of Zhuyeshigao granule on tumor necrosis factor-alpha and interleukins serum protein levels in rats with radiation esophagitis.
abstract: OBJECTIVE
  To investigate the effects of Zhuyeshigao granule (ZSG) on tumor necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1), IL-2, IL-6, and IL-8 in rats with radiation esophagitis.
  
  
  METHODS
  Fifty Wistar rats were randomly divided into five groups (10 rats in each group): control (without radiation), saline-treated, and low, medium, and high-dose ISG-treated groups. Rats were given normal saline (10 mL/kg) or 1.15, 2.3, or 4.6 g/kg ZSG by intragastric administration once a day for 7 days. A rat model of radiation esophagitis was established by local irradiation of Co60 (490.25 cGy/min, totaling 30 Gy). The administration of ZSG was continued for another 7 days and on the 7th day post-irradiation, inferior vena cava blood was collected. The serum was separated, and TNF-alpha, IL-1, IL-2, IL-6, and IL-8 protein levels were determined.
  
  
  RESULTS
  Inflammatory response factors were found in the serum of each group. However, levels in ZSG-treated groups were significantly lower than in the saline-treated group (P < 0.05).
  
  
  CONCLUSIONS
  ZSG may prevent the development of radiation esophagitis, perhaps by inhibiting the generation and release of the inflammatory response factors TNF-alpha, IL-1, IL-2, IL-6, and IL-8.
authors.forename: Junzhang
authors.initials: J
authors.lastname: Lu
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
authors.forename: Xiutang
authors.initials: X
authors.lastname: Cao
authors.forename: Minghui
authors.initials: M
authors.lastname: Yang
authors.forename: Hong
authors.initials: H
authors.lastname: Zhao
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D004941:Esophagitis / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007378:Interleukins / Q000097:blood*; D008297:Male; D011832:Radiation Injuries / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D011837:Radiation-Protective Agents / Q000008:administration & dosage*; D011878:Radiotherapy / Q000009:adverse effects*; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D004365:Drugs, Chinese Herbal; D007378:Interleukins; D011837:Radiation-Protective Agents; D014409:Tumor Necrosis Factor-alpha