title: Endplates changes related to age and vertebral segment.
abstract: Endplate separations are defined as the presence of a space between the hyaline cartilage and the cortical bone of the adjacent vertebral body. This study evaluates endplate separations from the vertebral body and intervertebral discs and verifies if endplate separation is related to age and the spinal level. Groups were formed based on age (20-40 and 41-85 years old) and the vertebral segment (T7-T8 and L4-L5 segments). Histological analysis included assessment of the length of the vertebral endplates, the number and dimensions of the separations, and orientation of the collagen fibers, in the mid-sagittal slice. Two indexes were created: the separation index (number of separations/vertebral length) and separation extension index (sum of all separations/vertebral length). The results of the study demonstrated a direct relationship between the density of separations in the endplate and two variables: age and spinal level.
authors.affiliation: Department of Biomechanics, Medicine, and Rehabilitation of the Locomotor Apparatus, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Bandeirantes Avenue 3900, 14049-900 Ribeirão Preto, SP, Brazil.
authors.forename: Carlos Fernando P S
authors.initials: CF
authors.lastname: Herrero
authors.affiliation: Department of Pathology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Bandeirantes Avenue 3900, 14049-900 Ribeirão Preto, SP, Brazil.
authors.forename: Sergio Britto
authors.initials: SB
authors.lastname: Garcia
authors.affiliation: Department of Biomechanics, Medicine, and Rehabilitation of the Locomotor Apparatus, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Bandeirantes Avenue 3900, 14049-900 Ribeirão Preto, SP, Brazil.
authors.forename: Luis Vicente
authors.initials: LV
authors.lastname: Garcia
authors.affiliation: Department of Biomechanics, Medicine, and Rehabilitation of the Locomotor Apparatus, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Bandeirantes Avenue 3900, 14049-900 Ribeirão Preto, SP, Brazil.
authors.forename: Helton Luiz
authors.initials: HL
authors.lastname: Aparecido Defino
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002102:Cadaver; D005260:Female; D006801:Humans; D051457:Hyaline Cartilage / Q000473:pathology* / Q000601:surgery; D007403:Intervertebral Disc / Q000473:pathology* / Q000601:surgery; D008159:Lumbar Vertebrae / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D013131:Spine / Q000473:pathology* / Q000601:surgery