title: [Incidence of haematological neoplasms in Castilla y León, Spain].
abstract: OBJECTIVE
  We aimed to assess the incidence of haematological neoplasms (HNs) in Castilla y León (2,5 million inhabitants) and its distribution by age, gender and histological type.
  
  
  METHODS
  The epidemiological profile based on the described variables of the 10,943 HNs diagnosed during a 10-years period was analyzed, compared with other studies.
  
  
  RESULTS
  The overall age-adjusted incidence was 29.4 cases/10(5) inhabitants-year, with some geographical differences. The mean age was 67.3 years, with a turning point between the 6th-7th decades of life from which there was a very significant increase of incidence. Two relevant facts where simultaneous with advancing age: decreased lymphoid neoplasms incidence and increased low degree neoplasms incidence. Lymphoid low degree neoplasms accounted for half of the registered processes, showed the greatest preference for male and reached the mode before the rest of neoplasms. Myeloid neoplasms incidence (9.5) was higher than that reported in other European registries, specially compared to southern European countries, opposite to lymphoid neoplasms incidence (20.0).
  
  
  CONCLUSIONS
  A higher myeloid neoplasms incidence and lower lymphoid one than expected was observed. The turning point of incidence is between the 6th-7th decades of life, with a preference for male that decreases with age. There is an increased incidence of HNs in the area where a higher density of potentially polluting facilities is concentrated.
authors.affiliation: Servicio de Hematología, Complejo Asistencial Universitario de León, León, España. Electronic address: jrodriguezgar@saludcastillayleon.es.
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Rodríguez-García
authors.affiliation: Servicio de Hematología, Complejo Asistencial Universitario de Salamanca, Salamanca, España.
authors.forename: Lourdes
authors.initials: L
authors.lastname: Vázquez
authors.affiliation: Servicio de Hematología, Complejo Asistencial Universitario de León, León, España.
authors.forename: Fernando
authors.initials: F
authors.lastname: Ramos
authors.affiliation: Servicio de Hematología, Complejo Asistencial Universitario de Burgos, Burgos, España.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Cuevas
authors.affiliation: Servicio de Hematología, Complejo Asistencial Universitario de Salamanca, Salamanca, España; Servicio de Hematología, Complejo Asistencial de Zamora, Zamora, España.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Martín
authors.affiliation: Servicio de Hematología, Hospital El Bierzo, Ponferrada, León, España.
authors.forename: Alicia
authors.initials: A
authors.lastname: Smucler
authors.affiliation: Servicio de Hematología, Hospital Clínico Universitario de Valladolid, Valladolid, España.
authors.forename: Dulce Nombre
authors.initials: DN
authors.lastname: Guerola
authors.affiliation: Servicio de Hematología, Hospital Universitario Río Hortega, Valladolid, España.
authors.forename: Alberto
authors.initials: A
authors.lastname: Cantalapiedra
authors.affiliation: Servicio de Hematología, Complejo Asistencial de Palencia, Palencia, España.
authors.forename: José María
authors.initials: JM
authors.lastname: Alonso
authors.affiliation: Servicio de Hematología, Complejo Asistencial Universitario de León, León, España.
authors.forename: Silvia
authors.initials: S
authors.lastname: Fernández
authors.affiliation: Servicio de Hematología, Complejo Asistencial Universitario de Salamanca, Salamanca, España.
authors.forename: Eva
authors.initials: E
authors.lastname: Díez
authors.affiliation: Servicio de Hematología, Complejo Asistencial de Ávila, Ávila, España.
authors.forename: María Jesús
authors.initials: MJ
authors.lastname: Rodríguez
authors.affiliation: Servicio de Hematología, Complejo Asistencial de Segovia, Segovia, España.
authors.forename: María José
authors.initials: MJ
authors.lastname: Calmuntia
authors.affiliation: Servicio de Hematología, Complejo Asistencial de Soria, Soria, España.
authors.forename: Carlos
authors.initials: C
authors.lastname: Aguilar
authors.affiliation: Servicio de Hematología, Complejo Asistencial de Zamora, Zamora, España.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Sierra
authors.affiliation: Servicio de Hematología, Complejo Asistencial de Soria, Soria, España.
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Gracia
authors.affiliation: Servicio de Hematología, Hospital Clínico Universitario de Valladolid, Valladolid, España.
authors.forename: María José
authors.initials: MJ
authors.lastname: Cebeira
authors.affiliation: Servicio de Hematología, Hospital Santos Reyes, Aranda de Duero, Burgos, España.
authors.forename: Rosa
authors.initials: R
authors.lastname: Cantalejo
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D004787:Environmental Pollution / Q000009:adverse effects; D005260:Female; D019337:Hematologic Neoplasms / Q000145:classification / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008232:Lymphoproliferative Disorders / Q000453:epidemiology; D008297:Male; D008415:Mastocytosis / Q000453:epidemiology; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000453:epidemiology; D054437:Myelodysplastic-Myeloproliferative Diseases / Q000453:epidemiology; D009196:Myeloproliferative Disorders / Q000453:epidemiology; D012189:Retrospective Studies; D017678:Sex Distribution; D013030:Spain / Q000453:epidemiology; D055815:Young Adult
keywords: Epidemiology; Epidemiología; Haematological neoplasms; Incidence; Incidencia; Leucemia; Leukemia; Linfoma; Lymphoid neoplasms; Lymphoma; Mieloma; Myeloid neoplasms; Myeloma; Neoplasias hematopoyéticas; Neoplasias linfoides; Neoplasias mieloides