title: Hyperuricemia and incident atrial fibrillation in a normotensive elderly population in Taiwan.
abstract: OBJECTIVE
  Atrial fibrillation (AF) is an important cardiovascular disease in the elderly. The association between hyperuricemia and AF is unclear. Therefore, we aimed to investigate the prospective relationship between uric acid and development of AF in a nationally representative cohort of elderly people.
  
  
  RESULTS
  A total of 1485 elderly people (age ≥ 65 yrs) from the Elderly Nutrition and Health Survey in Taiwan (1999-2000) were without AF on "electrocardiography" at baseline. Incident AF events (International Classification of Diseases, Ninth Revision, Clinical Modification, ICD-9-CM: 427.31) were identified using data from the National Health Insurance Dataset. Hyperuricemia was defined as levels of uric acid >7.0 mg/dL in men and 6.0 mg/dL in women. A Cox proportional hazards model was used to evaluate the association between hyperuricemia and incident AF. The follow-up period was from 1999 to 2000 to 2008. During the follow-up period (median: 9.16 yrs), 90 AF events occurred (44 in men and 46 in women). Older age, elevated systolic blood pressure, being an ex-smoker, and high uric acid were positively associated with incident AF. Hyperuricemia was positively associated with incident AF in normotensive (age-adjusted hazard ratio (HR): 2.65 and 95% confidence intervals: 1.05-6.69), but not in (1.20:0.74-1.94) hypertensive individuals (systolic blood pressure ≥130 or diastolic blood pressure ≥85 or using hypertensive medicine). A significant association between hyperuricemia and AF (3.78; 1.24-11.59) remained after adjusting for other potential confounders among normotensive older persons.
  
  
  CONCLUSIONS
  Hyperuricemia is associated with the development of AF in elderly people with normal blood pressure.
authors.affiliation: Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
authors.forename: S-Y
authors.initials: SY
authors.lastname: Chuang
authors.affiliation: Department of Medicine, Branch of Hsinchu, National Taiwan University Hospital, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan.
authors.forename: C-C
authors.initials: CC
authors.lastname: Wu
authors.affiliation: School of Medicine, National Yang-Ming University, Taipei, Taiwan; Healthcare and Management Center, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Medicine, National Yang-Ming University, Taiwan.
authors.forename: P-F
authors.initials: PF
authors.lastname: Hsu
authors.affiliation: Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
authors.forename: R
authors.initials: R
authors.lastname: Chia-Yu Chen
authors.affiliation: Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
authors.forename: W-L
authors.initials: WL
authors.lastname: Liu
authors.affiliation: Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
authors.forename: Y-Y
authors.initials: YY
authors.lastname: Hsu
authors.affiliation: Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan; Institute of Epidemiology and Institute of Microbiology and Biochemistry, National Taiwan University, Taipei, Taiwan; School of Public Health, Department of medicine, National Yang Ming University, Taipei, Taiwan; Institute of BioMedical Sciences, Academia Sinica, Taipei, Taiwan. Electronic address: pan@ibms.sinica.edu.tw.
authors.forename: W-H
authors.initials: WH
authors.lastname: Pan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001281:Atrial Fibrillation / Q000150:complications / Q000453:epidemiology*; D001794:Blood Pressure / Q000502:physiology*; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000453:epidemiology*; D033461:Hyperuricemia / Q000150:complications / Q000453:epidemiology*; D015994:Incidence; D008297:Male; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D011795:Surveys and Questionnaires; D013624:Taiwan / Q000453:epidemiology; D014527:Uric Acid / Q000097:blood
chemical_list: D014527:Uric Acid
keywords: Atrial fibrillation; Elderly population; Hyperuricemia