title: Comparing cutaneous research funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases with 2010 Global Burden of Disease results.
abstract: OBJECTIVE
  Disease burden data helps guide research prioritization.
  
  
  OBJECTIVE
  To determine the extent to which grants issued by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) reflect disease burden, measured by disability-adjusted life years (DALYs) from Global Burden of Disease (GBD) 2010 project.
  
  
  METHODS
  Two investigators independently assessed 15 skin conditions studied by GBD 2010 in the NIAMS database for grants issued in 2013. The 15 skin diseases were matched to their respective DALYs from GBD 2010.
  
  
  METHODS
  The United States NIAMS database and GBD 2010 skin condition disability data.
  
  
  METHODS
  Relationship of NIAMS grant database topic funding with percent total GBD 2010 DALY and DALY rank for 15 skin conditions.
  
  
  RESULTS
  During fiscal year 2013, 1,443 NIAMS grants were issued at a total value of $424 million. Of these grants, 17.7% covered skin topics. Of the total skin disease funding, 82% (91 grants) were categorized as "general cutaneous research." Psoriasis, leprosy, and "other skin and subcutaneous diseases" (ie; immunobullous disorders, vitiligo, and hidradenitis suppurativa) were over-represented when funding was compared with disability. Conversely, cellulitis, decubitus ulcer, urticaria, acne vulgaris, viral skin diseases, fungal skin diseases, scabies, and melanoma were under-represented. Conditions for which disability and funding appeared well-matched were dermatitis, squamous and basal cell carcinoma, pruritus, bacterial skin diseases, and alopecia areata.
  
  
  CONCLUSIONS
  Degree of representation in NIAMS is partly correlated with DALY metrics. Grant funding was well-matched with disability metrics for five of the 15 studied skin diseases, while two skin diseases were over-represented and seven were under-represented. Global burden estimates provide increasingly transparent and important information for investigating and prioritizing national research funding allocations.
authors.affiliation: College of Physicians and Surgeons, Columbia University, New York, New York, United States of America.
authors.forename: Chante
authors.initials: C
authors.lastname: Karimkhani
authors.affiliation: School of Medicine, Georgetown University, Washington, District of Columbia, United States of America.
authors.forename: Lindsay N
authors.initials: LN
authors.lastname: Boyers
authors.affiliation: Department of Biostatistics and Epidemiology and Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
authors.forename: David J
authors.initials: DJ
authors.lastname: Margolis
authors.affiliation: Institute for Health Metrics and Evaluation, University of Washington, Seattle, Washington, United States of America.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Naghavi
authors.affiliation: Department of Dermatology, Kings College Hospital NHS Trust, London, United Kingdom.
authors.forename: Roderick J
authors.initials: RJ
authors.lastname: Hay
authors.affiliation: Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, United Kingdom.
authors.forename: Hywel C
authors.initials: HC
authors.lastname: Williams
authors.affiliation: Department of Dermatology, Azienda Ospedaliera papa Giovanni XXIII, Bergamo, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Naldi
authors.affiliation: Institute for Health Metrics and Evaluation, University of Washington, Seattle, Washington, United States of America.
authors.forename: Luc E
authors.initials: LE
authors.lastname: Coffeng
authors.affiliation: Dermatoepidemiology Unit, Veterans Affairs Medical Center Providence, Providence, Rhode Island, United States of America; Department of Dermatology, Rode Island Hospital, Providence, Rhode Island, United States of America; Departments of Dermatology and Epidemiology, Brown University, Providence, Rhode Island, United States of America.
authors.forename: Martin A
authors.initials: MA
authors.lastname: Weinstock
authors.affiliation: Department of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America; Dermatology Service, Unites States Department of Veterans Affairs, Eastern Colorado Health Care System, Denver, Colorado, United States of America.
authors.forename: Cory A
authors.initials: CA
authors.lastname: Dunnick
authors.affiliation: University of Colorado School of Medicine, Aurora, Colorado, United States of America.
authors.forename: Hannah
authors.initials: H
authors.lastname: Pederson
authors.affiliation: Institute for Health Metrics and Evaluation, University of Washington, Seattle, Washington, United States of America.
authors.forename: Theo
authors.initials: T
authors.lastname: Vos
authors.affiliation: Institute for Health Metrics and Evaluation, University of Washington, Seattle, Washington, United States of America.
authors.forename: Christopher J L
authors.initials: CJ
authors.lastname: Murray
authors.affiliation: Department of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America; Dermatology Service, Unites States Department of Veterans Affairs, Eastern Colorado Health Care System, Denver, Colorado, United States of America; Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America.
authors.forename: Robert P
authors.initials: RP
authors.lastname: Dellavalle
mesh_terms: D035843:Biomedical Research / Q000191:economics*; D017281:Cost of Illness; D006233:Persons with Disabilities; D005260:Female; D005380:Financing, Government; D014943:Global Health; D006801:Humans; D008297:Male; D054580:National Institute of Arthritis and Musculoskeletal and Skin Diseases (U.S.) / Q000191:economics*; D019057:Quality-Adjusted Life Years; D012871:Skin Diseases / Q000191:economics* / Q000628:therapy; D014481:United States