title: Comparison of repaglinide and metformin versus metformin alone for type 2 diabetes: a meta-analysis of randomized controlled trials.
abstract: We conducted a meta-analysis to compare the efficacy and safety of repaglinide plus metformin with metformin alone on type 2 diabetes. Twenty-two studies were included in this meta-analysis. Results showed combination therapy was safe and could gain better outcomes in glycemic control. Well-designed studies are required to confirm this conclusion.
authors.affiliation: Department of Pharmacy, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, PR China; Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, PR China.
authors.forename: Jinjin
authors.initials: J
authors.lastname: Yin
authors.affiliation: Department of Pharmacy, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, PR China; Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, PR China.
authors.forename: Houliang
authors.initials: H
authors.lastname: Deng
authors.affiliation: Institute of Digestive Disease, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, PR China.
authors.forename: Shumin
authors.initials: S
authors.lastname: Qin
authors.affiliation: Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, PR China.
authors.forename: Waijiao
authors.initials: W
authors.lastname: Tang
authors.affiliation: Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, PR China.
authors.forename: Lu
authors.initials: L
authors.lastname: Zeng
authors.affiliation: Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, PR China. Electronic address: zhoubj163@163.com.
authors.forename: Benjie
authors.initials: B
authors.lastname: Zhou
mesh_terms: D002219:Carbamates / Q000009:adverse effects / Q000627:therapeutic use*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D004359:Drug Therapy, Combination / Q000009:adverse effects; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D008687:Metformin / Q000009:adverse effects / Q000627:therapeutic use*; D010880:Piperidines / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D002219:Carbamates; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D008687:Metformin; D010880:Piperidines; C072379:repaglinide
keywords: Combination therapy; Meta-analysis; Metformin; Repaglinide; Type 2 diabetes mellitus