title: Effect of gender on the GH-IGF-I response to anaerobic exercise in young adults.
abstract: Exercise-associated effects on the growth hormone-insulin-like growth factor-I (GH-IGF-I) axis were studied, mainly after aerobic exercise. We determined the gender effect on the GH-IGF-I axis response to a standard all-out Wingate anaerobic test (WAnT) in healthy active young adult men and women (men = 12 and women = 16; age range: 24-34 years). Blood samples for GH and IGF-I, key elements of the GH-IGF-I axis, were collected before and 20, 30, 40, and 60 minutes after the beginning of exercise. In addition, we collected postexercise blood lactate levels. Postexercise lactate levels were higher among men; however, this difference did not reach statistical significance (13.8 ± 1.3 vs. 11.1 ± 1.0 mmol·L, respectively; p = 0.1). The WAnT was associated with a significant increase in GH in both genders. However, GH peak was greater among women (10.8 ± 1.8 vs. 5.6 ± 1.4 ng·ml, in women and men, respectively; p < 0.01). In addition, postexercise GH peak occurred significantly earlier in female (20 minutes) compared with male participants (40 minutes). Exercise was associated with a significant increase in IGF only among men (from 166.8 ± 8.4 to 186.9 ± 9.3; p < 0.02); however, no significant between-gender effect was found. In summary, supramaximal anaerobic exercise was associated with a greater and earlier postexercise GH peak in women compared with men. All together, the results suggest anaerobic exercise-related anabolic-type hormonal response.
authors.affiliation: 1Child Health and Sports Center, Pediatric Department, Meir Medical Center, Sackler School of Medicine, Tel-Aviv University, Israel; and 2The Zinman College of Physical Education and Sport Sciences, Wingate Institute, Netanya, Israel.
authors.forename: Alon
authors.initials: A
authors.lastname: Eliakim
authors.forename: Dan
authors.initials: D
authors.lastname: Nemet
authors.forename: Guy
authors.initials: G
authors.lastname: Most
authors.forename: Noa
authors.initials: N
authors.lastname: Rakover
authors.forename: Michal
authors.initials: M
authors.lastname: Pantanowitz
authors.forename: Yoav
authors.initials: Y
authors.lastname: Meckel
mesh_terms: D000328:Adult; D015308:Anaerobic Threshold / Q000502:physiology; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D019382:Human Growth Hormone / Q000097:blood*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D019344:Lactic Acid / Q000097:blood; D008297:Male; D012737:Sex Factors; D013997:Time Factors; D055815:Young Adult
chemical_list: D019382:Human Growth Hormone; D019344:Lactic Acid; D007334:Insulin-Like Growth Factor I