title: Acquired factor VII deficiency associated with acute myeloid leukemia.
abstract: Isolated acquired factor VII deficiency is a rare coagulopathy. It has been reported in 31 patients with malignancy, sepsis, postoperatively, aplastic anemia, and during bone marrow transplantation. We discuss, through a new case of acquired factor VII deficiency, the characteristics of this disease when it is associated with acute myeloid leukemia. Acquired factor VII deficiency in hematological diseases can be caused by intensive chemotherapy, infections, or hepatic dysfunction. The best treatment in developing countries remains corticosteroids associated with plasma exchange, frozen plasma, and antibiotics.
authors.affiliation: aHematology & Pediatric Oncology Department, 20 Aout Hospital, Casablanca University Medical Centre bHematology Laboratory Unit, Casablanca Ibn Roch Medical Centre, Casablanca, Morocco.
authors.forename: Soumaya
authors.initials: S
authors.lastname: Anoun
authors.forename: Mouna
authors.initials: M
authors.lastname: Lamchahab
authors.forename: Bouchra
authors.initials: B
authors.lastname: Oukkache
authors.forename: Maryam
authors.initials: M
authors.lastname: Qachouh
authors.forename: Said
authors.initials: S
authors.lastname: Benchekroun
authors.forename: Asmaa
authors.initials: A
authors.lastname: Quessar
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D016470:Bacteremia / Q000097:blood / Q000209:etiology; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects; D003630:Daunorubicin / Q000008:administration & dosage / Q000009:adverse effects; D005167:Factor VII / Q000276:immunology*; D005168:Factor VII Deficiency / Q000209:etiology* / Q000276:immunology; D017809:Fatal Outcome; D006098:Granulocytes / Q000201:enzymology; D006406:Hematoma / Q000209:etiology; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011552:Pseudomonas Infections / Q000097:blood / Q000209:etiology
chemical_list: D001323:Autoantibodies; D003561:Cytarabine; D005167:Factor VII; D003630:Daunorubicin