title: A spinal analog of memory reconsolidation enables reversal of hyperalgesia.
abstract: Hyperalgesia arising from sensitization of pain relays in the spinal dorsal horn shares many mechanistic and phenotypic parallels with memory formation. We discovered that mechanical hyperalgesia could be rendered labile and reversible in mice after reactivation of spinal pain pathways in a process analogous to memory reconsolidation. These findings reveal a previously unknown regulatory mechanism underlying hyperalgesia and demonstrate the existence of reconsolidation-like processes in a sensory system.
authors.affiliation: Unité de neurosciences cellulaires et moléculaire, Institut universitaire en santé mentale de Québec, Québec, Canada.
authors.forename: Robert P
authors.identifier: 0000000232876803
authors.initials: RP
authors.lastname: Bonin
authors.affiliation: 1] Unité de neurosciences cellulaires et moléculaire, Institut universitaire en santé mentale de Québec, Québec, Canada. [2] Department of Psychiatry and Neuroscience, Université Laval, Québec, Canada.
authors.forename: Yves
authors.identifier: 0000000257799330
authors.initials: Y
authors.lastname: De Koninck
mesh_terms: D000818:Animals; D000841:Anisomycin / Q000008:administration & dosage / Q000494:pharmacology; D002211:Capsaicin / Q000008:administration & dosage / Q000494:pharmacology; D059333:Central Nervous System Sensitization / Q000187:drug effects / Q000502:physiology; D004195:Disease Models, Animal; D006930:Hyperalgesia / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology*; D008297:Male; D008568:Memory / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology; D020671:Posterior Horn Cells / Q000187:drug effects / Q000503:physiopathology; D011500:Protein Synthesis Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D018689:Sensory System Agents / Q000008:administration & dosage / Q000494:pharmacology*; D013116:Spinal Cord / Q000166:cytology / Q000473:pathology / Q000503:physiopathology*
chemical_list: D011500:Protein Synthesis Inhibitors; D018689:Sensory System Agents; D000841:Anisomycin; D002211:Capsaicin