title: Dental and craniofacial characteristics in a patient with Hutchinson-Gilford progeria syndrome.
abstract: The Hutchinson-Gilford progeria syndrome (HGPS) is an exceptionally rare medical disorder caused by mutations in the lamin A/C gene. Affected patients display typical features of premature aging. Beside general medical disorders, these patients have several specific features related to the craniofacial phenotype and the oral cavity. In this article, the dental and craniofacial characteristics of a 9-year-old girl with HGPS are presented. It is the first report addressing orthodontic tooth movement and microbiological features in a HGPS patient. We describe and discuss pathologic findings and provide a detailed histology of the teeth which had to be extracted during initial treatment.
authors.affiliation: Department of Orthodontics, Dental Hospital, University of Bonn, Welschnonnenstr. 17, 53111, Bonn, Germany, c_reichert@web.de.
authors.forename: Christoph
authors.initials: C
authors.lastname: Reichert
authors.forename: Lina
authors.initials: L
authors.lastname: Gölz
authors.forename: Werner
authors.initials: W
authors.lastname: Götz
authors.forename: Michael
authors.initials: M
authors.lastname: Wolf
authors.forename: James
authors.initials: J
authors.lastname: Deschner
authors.forename: Andreas
authors.initials: A
authors.lastname: Jäger
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002648:Child; D003131:Combined Modality Therapy / Q000379:methods; D005260:Female; D006801:Humans; D010518:Periodontitis / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology*; D011371:Progeria / Q000175:diagnosis* / Q000628:therapy*; D014081:Tooth Extraction / Q000379:methods*; D014087:Tooth Movement Techniques / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents