title: Variants in motilin, somatostatin and their receptor genes and risk of biliary tract cancers and stones in Shanghai, China.
abstract: Altered motility of the gallbladder can result in gallstone and cholecystitis, which are important risk factor for biliary tract cancer. Motilin (MLN) and somatostatin (SST) are known important modulators of gallbladder motility. To determine whether genetic variants in motilin, somatostatin, and their receptor genes are associated with the risk of biliary tract cancers and stones, nine tag-SNPs were determined in 439 biliary tract cancer cases (253 gallbladder, 133 extrahepatic bile duct and 53 ampulla of Vater cancer cases), 429 biliary stone cases, and 447 population controls in a population-based case-control study in Shanghai, China. We found that subjects with theMLNRrs9568169 AA genotype andSSTR5rs169068 CC genotype were significantly associated with risk of extrahepatic bile duct cancer (OR =0.49, 95% CI: 0.27-0.89; OR =2.40, 95% CI: 1.13-5.13) compared to the major genotypes.MLNrs2281820 CT and rs3793079 AT genotypes had significantly increased risks of gallstones (OR =1.52, 95% CI: 1.06-2.18; OR =1.64, 95% CI: 1.20-2.25) compared to TT genotypes. Besides, Haplotype analysis showed thatMLNT-T-T haplotype (rs2281820-rs3793079-rs2281819) had a non-significantly elevated risk of gallstone (OR =1.30, 95% CI: 0.91-1.86) compared with C-A-A haplotype. To the best of our knowledge, this is the first study to report an association between genetic polymorphisms inMLN,MLNRand their receptor genes and risk of biliary tract cancers and stones.
authors.affiliation: Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200032, China.
authors.forename: Hong-Li
authors.initials: HL
authors.lastname: Xu
authors.affiliation: Cancer Prevention Institute of California, Fremont, CA 94538, USA ; Stanford Cancer Institute, Palo Alto, CA 94305, USA.
authors.forename: Ann W
authors.initials: AW
authors.lastname: Hsing
authors.affiliation: Division of Cancer Epidemiology and Genetics, NCI/NIH/DHHS, Bethesda, MD 20892, USA.
authors.forename: Jill
authors.initials: J
authors.lastname: Koshiol
authors.affiliation: Cancer Prevention Institute of California, Fremont, CA 94538, USA ; Stanford Cancer Institute, Palo Alto, CA 94305, USA.
authors.forename: Lisa W
authors.initials: LW
authors.lastname: Chu
authors.affiliation: Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200032, China.
authors.forename: Jia-Rong
authors.initials: JR
authors.lastname: Cheng
authors.affiliation: Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200032, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Gao
authors.affiliation: Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200032, China.
authors.forename: Yu-Ting
authors.initials: YT
authors.lastname: Tan
authors.affiliation: Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200032, China ; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors.forename: Bing-Sheng
authors.initials: BS
authors.lastname: Wang
authors.affiliation: Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200032, China ; Department of Pathology, Cancer Hospital, Fudan University, Shanghai 200032, China.
authors.forename: Ming-Chang
authors.initials: MC
authors.lastname: Shen
authors.affiliation: Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200032, China.
authors.forename: Yu-Tang
authors.initials: YT
authors.lastname: Gao
keywords: MLN and MLNR; SSTR2 and SSTR5; biliary tract cancer; gallstone; genetic susceptibility