title: The role of androgen hormones in early follicular development.
abstract: Background. Although chronic hyperandrogenism, a typical feature of polycystic ovary syndrome, is often associated with disturbed reproductive performance, androgens have been shown to promote ovarian follicle growth in shorter exposures. Here, we review the main effects of androgens on the regulation of early folliculogenesis and the potential of their application in improving follicular in vitro growth. Review. Androgens may affect folliculogenesis directly via androgen receptors (ARs) or indirectly through aromatization to estrogen. ARs are highly expressed in the granulosa and theca cells of early stage follicles and slightly expressed in mature follicles. Short-term androgen exposure augments FSH receptor expression in the granulosa cells of developing follicles and enhances the FSH-induced cAMP formation necessary for the transcription of genes involved in the control of follicular cell proliferation and differentiation. AR activation also increases insulin-like growth factor (IGF-1) and its receptor gene expression in the granulosa and theca cells of growing follicles and in the oocytes of primordial follicles, thus facilitating IGF-1 actions in both follicular recruitment and subsequent development. Conclusion. During the early and intermediate stages of follicular maturation, locally produced androgens facilitate the transition of follicles from the dormant to the growing pool as well as their further development.
authors.affiliation: Sector of Human Reproduction, Department of Gynecology & Obstetrics, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes, 3900 Ribeirão Preto, SP, Brazil.
authors.forename: Catiele Garcia
authors.initials: CG
authors.lastname: Gervásio
authors.affiliation: Sector of Human Reproduction, Department of Gynecology & Obstetrics, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes, 3900 Ribeirão Preto, SP, Brazil.
authors.forename: Marcelo Picinin
authors.initials: MP
authors.lastname: Bernuci
authors.affiliation: Sector of Human Reproduction, Department of Gynecology & Obstetrics, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes, 3900 Ribeirão Preto, SP, Brazil.
authors.forename: Marcos Felipe
authors.initials: MF
authors.lastname: Silva-de-Sá
authors.affiliation: Sector of Human Reproduction, Department of Gynecology & Obstetrics, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes, 3900 Ribeirão Preto, SP, Brazil.
authors.forename: Ana Carolina Japur de Sá
authors.initials: AC
authors.lastname: Rosa-E-Silva