title: Diagnostic challenges in alcohol use disorder and alcoholic liver disease.
abstract: Alcohol use disorders represent a heterogeneous spectrum of clinical manifestations that have been defined by the Diagnostic and Statistical Manual of Mental Disorders-5. Excessive alcohol intake can lead to damage of various organs, including the liver. Alcoholic liver disease includes different injuries ranging from steatosis to cirrhosis and implicates a diagnostic assessment of the liver disease and of its possible complications. There is growing interest in the possible different tools for assessing previous alcohol consumption and for establishing the severity of liver injury, especially by non-invasive methods.
authors.affiliation: Luisa Vonghia, Peter Michielsen, Geert Dom, Sven Francque, Department of Gastroenterology and Hepatology, University Hospital Antwerp, Wilrijkstraat 10, 2650 Edegem, Belgium.
authors.forename: Luisa
authors.initials: L
authors.lastname: Vonghia
authors.affiliation: Luisa Vonghia, Peter Michielsen, Geert Dom, Sven Francque, Department of Gastroenterology and Hepatology, University Hospital Antwerp, Wilrijkstraat 10, 2650 Edegem, Belgium.
authors.forename: Peter
authors.initials: P
authors.lastname: Michielsen
authors.affiliation: Luisa Vonghia, Peter Michielsen, Geert Dom, Sven Francque, Department of Gastroenterology and Hepatology, University Hospital Antwerp, Wilrijkstraat 10, 2650 Edegem, Belgium.
authors.forename: Geert
authors.initials: G
authors.lastname: Dom
authors.affiliation: Luisa Vonghia, Peter Michielsen, Geert Dom, Sven Francque, Department of Gastroenterology and Hepatology, University Hospital Antwerp, Wilrijkstraat 10, 2650 Edegem, Belgium.
authors.forename: Sven
authors.initials: S
authors.lastname: Francque
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects* / Q000453:epidemiology; D020268:Alcohol-Induced Disorders, Nervous System / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D019973:Alcohol-Related Disorders / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D003952:Diagnostic Imaging; D018450:Disease Progression; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D011237:Predictive Value of Tests; D011379:Prognosis; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers
keywords: Alcohol use disorder; Alcoholic liver disease; Diagnosis; Diagnostic and Statistical Manual of Mental Disorders-5; Markers of previous alcohol consumption; Non-invasive fibrosis assessment; Screening tests