title: Synthesis of multifunctional magnetic nanoflakes for magnetic resonance imaging, hyperthermia, and targeting.
abstract: Iron oxide nanoparticles (IOs) are intrinsically theranostic agents that could be used for magnetic resonance imaging (MRI) and local hyperthermia or tissue thermal ablation. Yet, effective hyperthermia and high MR contrast have not been demonstrated within the same nanoparticle configuration. Here, magnetic nanoconstructs are obtained by confining multiple, ∼ 20 nm nanocubes (NCs) within a deoxy-chitosan core. The resulting nanoconstructs-magnetic nanoflakes (MNFs)-exhibit a hydrodynamic diameter of 156 ± 3.6 nm, with a polydispersity index of ∼0.2, and are stable in PBS up to 7 days. Upon exposure to an alternating magnetic field of 512 kHz and 10 kA m(-1), MNFs provide a specific absorption rate (SAR) of ∼75 W gFe(-1), which is 4-15 times larger than that measured for conventional IOs. Moreover, the same nanoconstructs provide a remarkably high transverse relaxivity of ∼500 (mM s)(-1), at 1.41T. MNFs represent a first step toward the realization of nanoconstructs with superior relaxometric and ablation properties for more effective theranostics.
authors.affiliation: Houston Methodist Research Institute, 6670 Bertner Avenue, Houston, Texas 77030, United States.
authors.forename: Antonio
authors.initials: A
authors.lastname: Cervadoro
authors.forename: Minjung
authors.initials: M
authors.lastname: Cho
authors.forename: Jaehong
authors.initials: J
authors.lastname: Key
authors.forename: Christy
authors.initials: C
authors.lastname: Cooper
authors.forename: Cinzia
authors.initials: C
authors.lastname: Stigliano
authors.forename: Santosh
authors.initials: S
authors.lastname: Aryal
authors.forename: Audrius
authors.initials: A
authors.lastname: Brazdeikis
authors.forename: James F
authors.initials: JF
authors.lastname: Leary
authors.forename: Paolo
authors.initials: P
authors.lastname: Decuzzi
mesh_terms: D016923:Cell Death; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D016503:Drug Delivery Systems; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D006979:Hyperthermia, Induced; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles / Q000633:toxicity
chemical_list: D058185:Magnetite Nanoparticles