title: [To ponder the key issues in achieving wound healing].
abstract: The understanding of the mechanism of wound healing is deepening. Key issues in the process of wound healing need to be seriously considered, i.e. how to establish the concept of application of phasic and selective means to promote wound healing according to the characteristics of a network and sequential process; to correctly assess the function and status of macrophages in wound healing and to explore the conditions of regulating timely infiltration of macrophages, as well as the phasic and orderly expression of type Iand type II macrophages; to properly understand the role and status of extracellular matrix components or the three-dimensional structure and morphology in wound healing; to elucidate the effects of wound microenvironment on the proliferation and differentiation of stem cells; to find out the intrinsic mechanism of negative pressure in the process of wound healing. The understanding of the above problems are of great value for us to grasp the intrinsic mechanism of wound healing in order to establish a more effective and rational treatment of wound.
authors.affiliation: Shanghai Institute of Burns, Shanghai Research Center of Wound Repair, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.
authors.forename: Shuliang
authors.initials: S
authors.lastname: Lu
mesh_terms: D002454:Cell Differentiation; D005109:Extracellular Matrix; D006801:Humans; D008264:Macrophages; D054843:Negative-Pressure Wound Therapy; D013234:Stem Cells; D014945:Wound Healing; D014947:Wounds and Injuries / Q000628:therapy*