title: eMERGEing progress in genomics-the first seven years.
abstract: The electronic MEdical Records & GEnomics (eMERGE) network was established in 2007 by the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH) in part to explore the utility of electronic medical records (EMRs) in genome science. The initial focus was on discovery primarily using the genome-wide association paradigm, but more recently, the network has begun evaluating mechanisms to implement new genomic information coupled to clinical decision support into EMRs. Herein, we describe this evolution including the development of the individual and merged eMERGE genomic datasets, the contribution the network has made toward genomic discovery and human health, and the steps taken toward the next generation genotype-phenotype association studies and clinical implementation.
authors.affiliation: Center for Human Genetics Research, Vanderbilt University Nashville, TN, USA ; Department of Molecular Physiology and Biophysics, Vanderbilt University Nashville, TN, USA.
authors.forename: Dana C
authors.initials: DC
authors.lastname: Crawford
authors.affiliation: Medical Genetics, Department of Medicine, School of Medicine, University of Washington Seattle, WA, USA ; Department of Genome Sciences, University of Washington Seattle, WA, USA.
authors.forename: David R
authors.initials: DR
authors.lastname: Crosslin
authors.affiliation: The Sigfried and Janet Weis Center for Research, Geisinger Health System Danville, PA, USA.
authors.forename: Gerard
authors.initials: G
authors.lastname: Tromp
authors.affiliation: Division of Cardiovascular Diseases and the Gonda Vascular Center, Mayo Clinic Rochester, MN, USA.
authors.forename: Iftikhar J
authors.initials: IJ
authors.lastname: Kullo
authors.affiliation: The Sigfried and Janet Weis Center for Research, Geisinger Health System Danville, PA, USA.
authors.forename: Helena
authors.initials: H
authors.lastname: Kuivaniemi
authors.affiliation: Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University Chicago, IL, USA.
authors.forename: M Geoffrey
authors.initials: MG
authors.lastname: Hayes
authors.affiliation: Department of Biomedical Informatics, Vanderbilt University Nashville, TN, USA ; Department of Medicine, Vanderbilt University Nashville, TN, USA.
authors.forename: Joshua C
authors.initials: JC
authors.lastname: Denny
authors.affiliation: Center for Human Genetics Research, Vanderbilt University Nashville, TN, USA ; Department of Biomedical Informatics, Vanderbilt University Nashville, TN, USA.
authors.forename: William S
authors.initials: WS
authors.lastname: Bush
authors.affiliation: Department of Epidemiology and Biostatistics, Case Western Reserve University Cleveland, OH, USA ; Institute for Computational Biology, Case Western Reserve University Cleveland, OH, USA.
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Haines
authors.affiliation: Department of Medicine, Vanderbilt University Nashville, TN, USA ; Department of Pharmacology, Vanderbilt University Nashville, TN, USA.
authors.forename: Dan M
authors.initials: DM
authors.lastname: Roden
authors.affiliation: Essentia Institute of Rural Health Duluth, MN, USA.
authors.forename: Catherine A
authors.initials: CA
authors.lastname: McCarty
authors.affiliation: Medical Genetics, Department of Medicine, School of Medicine, University of Washington Seattle, WA, USA ; Department of Genome Sciences, University of Washington Seattle, WA, USA.
authors.forename: Gail P
authors.initials: GP
authors.lastname: Jarvik
authors.affiliation: Department of Biochemistry and Molecular Biology, Pennsylvania State University University Park, PA, USA ; Center for Systems Genomics, Pennsylvania State University University Park, PA, USA.
authors.forename: Marylyn D
authors.initials: MD
authors.lastname: Ritchie
keywords: biobanks; electronic medical records; genome-wide association studies; pharmacogenomics