title: Longitudinal inflammation, cognitive decline, and Alzheimer's disease: a mini-review.
abstract: The role of inflammation in cognitive decline has generated considerable interest, although few longitudinal evaluations have been conducted. A review of the literature yields mixed findings but suggests that inflammatory dysregulation is evident and may be related to clinical outcomes. The directionality, magnitude, and progression of these associations remain unclear. Future studies employing multiple time points of inflammatory data along with Alzheimer's disease (AD) biomarkers are critical for explication of longitudinal inflammation in cognitive decline.
authors.affiliation: Neurology Department, Memory and Aging Center, University of California, San Francisco, San Francisco, California, USA.
authors.forename: B M
authors.initials: BM
authors.lastname: Bettcher
authors.affiliation: Neurology Department, Memory and Aging Center, University of California, San Francisco, San Francisco, California, USA.
authors.forename: J H
authors.initials: JH
authors.lastname: Kramer
mesh_terms: D000375:Aging / Q000276:immunology / Q000378:metabolism / Q000523:psychology; D000544:Alzheimer Disease / Q000276:immunology* / Q000378:metabolism / Q000523:psychology; D003072:Cognition Disorders / Q000276:immunology* / Q000378:metabolism / Q000523:psychology; D060825:Cognitive Dysfunction / Q000276:immunology / Q000378:metabolism / Q000523:psychology; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism; D012307:Risk Factors; D013997:Time Factors