title: [Clinical and physiological rationale for use of clonidine with articaine and adrenaline for local anesthesia in pediatric dentistry].
abstract: The study evaluated the effect of local anesthesia with articaine in different combinations with epinephrine and clonidine (articaine (4%) + epinephrine (1:200 000), articaine (4%) + clonidine (1:100 000), articaine (4%) + epinephrine (1:200 000) + clonidine (1:100 000), articaine (4%) + epinephrine (1:400 000) + clonidine (1:100 000)), on a number of physiological parameters in pediatric dental practice that characterize cardiovascular system, patient's degree of adaptation to a stressful situation and efficacy of analgesia. It is shown that in terms of impact on the cardiovascular system and stress adaptation indicators anesthesia including combination of epinephrine (1: 200 000) and clonidine (1: 100 000) in the anesthetic solution is the safest. Furthermore, this method ensures the most appropriate analgesic effect.
authors.forename: A V
authors.initials: AV
authors.lastname: Mel'nikova
authors.forename: I A
authors.initials: IA
authors.lastname: Shugaĭlov
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects*; D000766:Anesthesia, Dental / Q000009:adverse effects / Q000379:methods*; D000772:Anesthesia, Local / Q000009:adverse effects / Q000379:methods*; D000779:Anesthetics, Local / Q000008:administration & dosage*; D002319:Cardiovascular System / Q000187:drug effects*; D002355:Carticaine / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D003000:Clonidine / Q000008:administration & dosage / Q000009:adverse effects*; D004837:Epinephrine / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male
chemical_list: D000779:Anesthetics, Local; D002355:Carticaine; D003000:Clonidine; D004837:Epinephrine