title: New strategies for developing cardiovascular stent surfaces with novel functions (Review).
abstract: In this review, the authors summarize the developments in surface modification of cardiovascular materials especially in author's laboratory. The authors focus on three different strategies to construct multifunctional surfaces including coimmobilization of various biomolecules on stent surfaces, stem cell based therapy systems, and a single-molecule multipurpose modification strategy in vascular interventional therapy. The roles of various molecules like heparin, gallic acid, various aptamers, and nitric oxide are highlighted in the new strategies for developing cardiovascular stent surfaces with novel functions including excellent hemocompatibility, inhibiting smooth muscle cells proliferation, and native endothelium regeneration. The success of these multifunctional surfaces provides the tremendous potential in designing the next generation of vascular stents.
authors.affiliation: Key Laboratory of Advanced Technology of Materials of Education Ministry, Southwest Jiaotong University, Chengdu 610031, China and School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
authors.forename: Pengkai
authors.initials: P
authors.lastname: Qi
authors.affiliation: Key Laboratory of Advanced Technology of Materials of Education Ministry, Southwest Jiaotong University, Chengdu 610031, China and School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
authors.forename: Si
authors.initials: S
authors.lastname: Chen
authors.affiliation: Key Laboratory of Advanced Technology of Materials of Education Ministry, Southwest Jiaotong University, Chengdu 610031, China and School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
authors.affiliation: College of Stomatology, Anhui Medical University, Hefei 230032, China.
authors.forename: Jialong
authors.initials: J
authors.lastname: Chen
authors.affiliation: Key Laboratory of Advanced Technology of Materials of Education Ministry, Southwest Jiaotong University, Chengdu 610031, China and School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
authors.forename: Zhilu
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Key Laboratory of Advanced Technology of Materials of Education Ministry, Southwest Jiaotong University, Chengdu 610031, China and School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
authors.forename: Yajun
authors.initials: Y
authors.lastname: Weng
authors.affiliation: Key Laboratory of Advanced Technology of Materials of Education Ministry, Southwest Jiaotong University, Chengdu 610031, China and School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
authors.forename: Junying
authors.initials: J
authors.lastname: Chen
authors.affiliation: Key Laboratory of Advanced Technology of Materials of Education Ministry, Southwest Jiaotong University, Chengdu 610031, China and School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Wang
authors.affiliation: Max Bergmann Center of Biomaterials Dresden, Leibniz Institute of Polymer Research Dresden, Dresden 01097, Germany.
authors.forename: Manfred F
authors.initials: MF
authors.lastname: Maitz
authors.affiliation: Key Laboratory of Advanced Technology of Materials of Education Ministry, Southwest Jiaotong University, Chengdu 610031, China and School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Huang
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry* / Q000633:toxicity; D049109:Cell Proliferation / Q000187:drug effects; D005707:Gallic Acid / Q000737:chemistry; D006493:Heparin / Q000737:chemistry; D006801:Humans; D058185:Magnetite Nanoparticles / Q000737:chemistry; D032389:Myocytes, Smooth Muscle / Q000166:cytology / Q000378:metabolism; D011108:Polymers / Q000737:chemistry; D015607:Stents; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D058185:Magnetite Nanoparticles; D011108:Polymers; D005707:Gallic Acid; D006493:Heparin