title: Increasing access to kidney transplantation in countries with limited resources: the Indian experience with kidney paired donation.
abstract: According to the Indian chronic kidney disease registry, in 2010 only 2% of end stage kidney disease patients were managed with kidney transplantation, 37% were managed with dialysis and 61% were treated conservatively without renal replacement therapy. In countries like India, where a well-organized deceased donor kidney transplantation program is not available, living donor kidney transplantation is the major source of organs for kidney transplantation. The most common reason to decline a donor for directed living donation is ABO incompatibility, which eliminates up to one third of the potential living donor pool. Because access to transplantation with human leukocyte antigen (HLA)-desensitization protocols and ABO incompatible transplantation is very limited due to high costs and increased risk of infections from more intense immunosuppression, kidney paired donation (KPD) promises hope to a growing number of end stage kidney disease patients. KPD is a rapidly growing and cost-effective living donor kidney transplantation strategy for patients who are incompatible with their healthy, willing living donor. In principle, KPD is feasible for any centre that performs living donor kidney transplantation. In transplant centres with a large living donor kidney transplantation program KPD does not require extra infrastructure, decreases waiting time, avoids transplant tourism and prevents commercial trafficking. Although KPD is still underutilized in India, it has been performed more frequently in recent times. To substantially increase donor pool and transplant rates, transplant centres should work together towards a national KPD program and frame a uniform acceptable allocation policy.
authors.affiliation: Department of Nephrology and Clinical Transplantation, Institute of Kidney Diseases and Research Center, Dr HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Ahmedabad, India.
authors.forename: Vivek B
authors.initials: VB
authors.lastname: Kute
authors.forename: Aruna V
authors.initials: AV
authors.lastname: Vanikar
authors.forename: Pankaj R
authors.initials: PR
authors.lastname: Shah
authors.forename: Manoj R
authors.initials: MR
authors.lastname: Gumber
authors.forename: Himanshu V
authors.initials: HV
authors.lastname: Patel
authors.forename: Divyesh P
authors.initials: DP
authors.lastname: Engineer
authors.forename: Pranjal R
authors.initials: PR
authors.lastname: Modi
authors.forename: Veena R
authors.initials: VR
authors.lastname: Shah
authors.forename: Hargovind L
authors.initials: HL
authors.lastname: Trivedi
mesh_terms: D003362:Cost-Benefit Analysis; D003906:Developing Countries / Q000191:economics; D033001:Directed Tissue Donation / Q000191:economics / Q000331:legislation & jurisprudence; D017048:Health Care Costs; D006291:Health Policy; D006295:Health Resources / Q000191:economics / Q000331:legislation & jurisprudence / Q000458:organization & administration*; D006297:Health Services Accessibility / Q000191:economics / Q000331:legislation & jurisprudence / Q000458:organization & administration*; D054625:Healthcare Disparities / Q000191:economics / Q000331:legislation & jurisprudence; D006648:Histocompatibility; D006801:Humans; D007194:India / Q000453:epidemiology; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000191:economics / Q000453:epidemiology / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects / Q000191:economics / Q000331:legislation & jurisprudence; D019520:Living Donors / Q000331:legislation & jurisprudence / Q000600:supply & distribution*; D010043:Outcome and Process Assessment, Health Care / Q000191:economics / Q000331:legislation & jurisprudence / Q000458:organization & administration*; D011050:Policy Making; D013997:Time Factors; D016896:Treatment Outcome; D014850:Waiting Lists
keywords: dialysis; economic evaluation; end-stage kidney disease; living donor transplantation; transplantation