title: Tissue engineering of the esophagus.
abstract: Esophageal atresia occurs in 1 out of 3000 births. Current treatments involve esophageal replacement by using more distal parts of the gastrointestinal tract, such as the stomach, jejunum, and colon. Significant complications are associated with each treatment option. Tissue engineering may provide a therapeutic alternative for esophageal replacement. This article addresses the progress in esophageal tissue engineering using acellular and cell-seeded approaches. In addition, we discuss the potential direction of future approaches by critically appraising the results in the recent literature.
authors.affiliation: Surgery Unit, UCL Institute of Child Health and Great Ormond Street Hospital, 30 Guilford St, London WC1N 1EH, UK.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Maghsoudlou
authors.affiliation: Surgery Unit, UCL Institute of Child Health and Great Ormond Street Hospital, 30 Guilford St, London WC1N 1EH, UK.
authors.forename: Simon
authors.initials: S
authors.lastname: Eaton
authors.affiliation: Surgery Unit, UCL Institute of Child Health and Great Ormond Street Hospital, 30 Guilford St, London WC1N 1EH, UK. Electronic address: p.decoppi@ucl.ac.uk.
authors.forename: Paolo
authors.initials: P
authors.lastname: De Coppi
mesh_terms: D062088:Acellular Dermis; D019149:Bioreactors; D004933:Esophageal Atresia / Q000601:surgery*; D004947:Esophagus / Q000637:transplantation; D048091:Guided Tissue Regeneration / Q000379:methods*; D006801:Humans; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds
keywords: Acellular approach; Cell-seeded approach; Esophageal replacement; Tissue engineering