title: Periconceptional undernutrition in sheep leads to decreased locomotor activity in a natural environment.
abstract: Maternal undernutrition during pregnancy increases offspring obesity and metabolic disease risk. We hypothesized that periconceptional undernutrition in sheep from 60 days before conception through to day 30 of gestation (UN) would decrease voluntary locomotor activity in adult offspring. Distance travelled was measured at 18 months of age for ∼48 h in the paddock. Data were analysed using multiple regression analysis, with explanatory variables including sex, nutrition group, birth weight, average time between GPS measurements and percentage of time during the measurement period spent in daylight. Mean (±s.e.) distance walked (m/h) was greater for control (CON) than UN animals, and greater for females than males [110.2 (6.5), CON females; 110.7 (6.3), CON males; 105.1 (5.3), UN females and 95.5 (5.8), UN males; P = 0.02 for nutrition group effect and for sex effect]. Periconceptional undernutrition may lead to a significant decrease in voluntary physical activity in adult offspring.
authors.affiliation: 1 The Liggins Institute, the University of Auckland, Auckland, New Zealand.
authors.forename: E L
authors.initials: EL
authors.lastname: Donovan
authors.affiliation: 1 The Liggins Institute, the University of Auckland, Auckland, New Zealand.
authors.forename: C E
authors.initials: CE
authors.lastname: Hernandez
authors.affiliation: 3 AgResearch, Ruakura Research Centre, Hamilton, New Zealand.
authors.forename: L R
authors.initials: LR
authors.lastname: Matthews
authors.affiliation: 1 The Liggins Institute, the University of Auckland, Auckland, New Zealand.
authors.forename: M H
authors.initials: MH
authors.lastname: Oliver
authors.affiliation: 1 The Liggins Institute, the University of Auckland, Auckland, New Zealand.
authors.forename: A L
authors.initials: AL
authors.lastname: Jaquiery
authors.affiliation: 1 The Liggins Institute, the University of Auckland, Auckland, New Zealand.
authors.forename: F H
authors.initials: FH
authors.lastname: Bloomfield
authors.affiliation: 1 The Liggins Institute, the University of Auckland, Auckland, New Zealand.
authors.forename: J E
authors.initials: JE
authors.lastname: Harding