title: On the use of coupled shape priors for segmentation of magnetic resonance images of the knee.
abstract: Active contour techniques have been widely employed for medical image segmentation. Significant effort has been focused on the use of training data to build prior statistical models applicable specifically to problems where the objects of interest are embedded in cluttered background. Usually, the training data consist of whole shapes of certain organs or structures obtained manually by clinical experts. The resulting prior models enforce segmentation accuracy uniformly over the entire structure or structures to be identified. In this paper, we consider a new coupled prior shape model which is demonstrated to provide high accuracy, specifically in the region of the interest where precision is most needed for the application of the segmentation of the femur and tibia in magnetic resonance (MR) images. Experimental results for the segmentation of MR images of human knees demonstrate that the combination of the new coupled prior shape and a directional edge force provides the improved segmentation performance. Moreover, the new approach allows for equivalent accurate identification of bone marrow lesions, a promising biomarker related to osteoarthritis, to the current state of the art but requires significantly less manual interaction.
authors.forename: Jincheng
authors.initials: J
authors.lastname: Pang
authors.forename: Jeffrey B
authors.initials: JB
authors.lastname: Driban
authors.forename: Timothy E
authors.initials: TE
authors.lastname: McAlindon
authors.forename: José G
authors.initials: JG
authors.lastname: Tamez-Peña
authors.forename: Jurgen
authors.initials: J
authors.lastname: Fripp
authors.forename: Eric L
authors.initials: EL
authors.lastname: Miller
mesh_terms: D000368:Aged; D000465:Algorithms; D002358:Cartilage, Articular / Q000473:pathology; D016208:Databases, Factual; D005269:Femur / Q000473:pathology; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D007717:Knee / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000473:pathology; D013977:Tibia / Q000473:pathology