title: Homeostasis between gut-associated microorganisms and the immune system in Drosophila.
abstract: The metabolic activities of a given gut bacterium or gut commensal community fluctuate in a manner largely depending on the physicochemical parameters within the gut niche. Recognition of the bacterial metabolic status in situ, by a sensing of the gut metabolites as a signature of a specific bacterial metabolic activity, has been suggested to be a highly beneficial means for the host to maintain gut-microbe homeostasis. Recently, analysis of Drosophila gut immunity revealed that bacterial-derived uracil and uracil-modulated intestinal reactive oxygen species (ROS) generation play a pivotal role in diverse aspects of host-microbe interactions, such as pathogen clearance, commensal protection, intestinal cell regeneration, colitogenesis, and possibly also interorgan immunological communication. A deeper understanding of the role of uracil in Drosophila immunity will provide additional insight into the molecular mechanisms underlying host-microbe symbiosis and dysbiosis.
authors.affiliation: National Creative Research Initiative Center for Symbiosystem, School of Biological Sciences, Seoul National University, Seoul 151-742, South Korea; Department of Life Science, Ewha Womans University, Seoul 120-750, South Korea.
authors.forename: Hyejin
authors.initials: H
authors.lastname: You
authors.affiliation: College of Health Science, Ewha Womans University, Seoul 120-750, South Korea.
authors.forename: Won Jun
authors.initials: WJ
authors.lastname: Lee
authors.affiliation: National Creative Research Initiative Center for Symbiosystem, School of Biological Sciences, Seoul National University, Seoul 151-742, South Korea. Electronic address: lwj@snu.ac.kr.
authors.forename: Won-Jae
authors.initials: WJ
authors.lastname: Lee
mesh_terms: D000818:Animals; D004331:Drosophila melanogaster; D041981:Gastrointestinal Tract / Q000276:immunology* / Q000382:microbiology; D006706:Homeostasis; D006801:Humans; D007113:Immunity, Innate; D017382:Reactive Oxygen Species / Q000378:metabolism; D014498:Uracil / Q000276:immunology
chemical_list: D017382:Reactive Oxygen Species; D014498:Uracil