title: Associations between hOGG1 Ser326Cys polymorphism and increased body mass index and fasting glucose level in the Japanese general population.
abstract: BACKGROUND
  Evidence suggests that Ser326Cys, a genetic polymorphism of human 8-oxoguanine glycosylase 1 (hOGG1), is associated with insulin resistance and type 2 diabetes; however, the underlying mechanism is unclear. Recently, an animal study showed a significant association between the hOGG1 genotype and obesity, although evidence for such an association in humans is limited. The purpose of this study was to examine the association between the hOGG1 genotype and body mass index (BMI) and fasting blood glucose (FBG) levels.
  
  
  METHODS
  Cross-sectional analysis was conducted using the baseline survey data from a Japan Multi-Institutional Collaborative Cohort Study, which included 1793 participants aged 40-69 years. The hOGG1 polymorphism was detected using a multiplex polymerase chain reaction-based invader assay. Multiple linear regression, analysis of covariance, and logistic regression were used to control for confounding variables.
  
  
  RESULTS
  The Cys allele was significantly associated with increased BMI, FBG level, and total cholesterol (TC) level, even after adjustment for gender, age, energy intake, alcohol, smoking, physical activity, and family history of diabetes. An association with BMI was still observed after further adjustment for FBG and TC, but not for the study area (Amami or the mainland). The Cys/Cys genotype was significantly more prevalent in the participants with higher BMI (>27.5 kg/m(2)). However, the impact of genotype decreased and significance disappeared after adjusting for the study area.
  
  
  CONCLUSIONS
  The present results suggest that the study area being inside Japan confounds the association between hOGG1 genotype and obesity.
authors.affiliation: Department of Preventive Medicine, Faculty of Medicine, Saga University.
authors.forename: Megumi
authors.initials: M
authors.lastname: Hara
authors.forename: Kazuyo
authors.initials: K
authors.lastname: Nakamura
authors.forename: Hinako
authors.initials: H
authors.lastname: Nanri
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Nishida
authors.forename: Asahi
authors.initials: A
authors.lastname: Hishida
authors.forename: Sayo
authors.initials: S
authors.lastname: Kawai
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Hamajima
authors.forename: Yoshikuni
authors.initials: Y
authors.lastname: Kita
authors.forename: Sadao
authors.initials: S
authors.lastname: Suzuki
authors.forename: Eva Mariane
authors.initials: EM
authors.lastname: Mantjoro
authors.forename: Keizo
authors.initials: K
authors.lastname: Ohnaka
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Uemura
authors.forename: Daisuke
authors.initials: D
authors.lastname: Matsui
authors.forename: Isao
authors.initials: I
authors.lastname: Oze
authors.forename: Haruo
authors.initials: H
authors.lastname: Mikami
authors.forename: Michiaki
authors.initials: M
authors.lastname: Kubo
authors.forename: Hideo
authors.initials: H
authors.lastname: Tanaka
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000235:genetics*; D015992:Body Mass Index; D002784:Cholesterol / Q000235:genetics; D003430:Cross-Sectional Studies; D045647:DNA Glycosylases / Q000235:genetics*; D005215:Fasting; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics; D011110:Polymorphism, Genetic
chemical_list: D001786:Blood Glucose; D002784:Cholesterol; D045647:DNA Glycosylases; C479058:oxoguanine glycosylase 1, human