title: Bilateral ovarian cystadenoma in a geriatric African elephant (Loxodonta africana).
abstract: A 59-yr-old, captive female African elephant (Loxodonta africana) died of a cardiovascular collapse. Necropsy revealed bilateral replacement of the ovarian tissue by multiple cystic formations of up to 10 cm in diameter. The cysts were thin walled and filled with clear watery fluid. Smaller solid masses with an irregular surface projected from the wall of a few of the cysts. Histologically, the cystic structures were characterized by a single layer of well-differentiated cuboidal epithelial cells resting on a basement membrane. Occasionally the cysts contained nodular proliferations of single-layered, well-differentiated cuboidal epithelial cells forming anastomosing tubules and occasional papillary projections. The ovarian neoplasia was diagnosed as a bilateral multilocular serous ovarian cystadenoma. The nulliparous status and the advanced age may have contributed to the ovarian pathology.
authors.forename: Stefan
authors.initials: S
authors.lastname: Hoby
authors.forename: Fabio
authors.initials: F
authors.lastname: Aloisio
authors.forename: Vanessa L
authors.initials: VL
authors.lastname: Schumacher
mesh_terms: D000375:Aging; D000818:Animals; D003537:Cystadenoma / Q000473:pathology / Q000662:veterinary*; D004606:Elephants; D005260:Female; D010051:Ovarian Neoplasms / Q000473:pathology / Q000662:veterinary*