title: Germ cell transport across the seminiferous epithelium during spermatogenesis.
abstract: Transport of germ cells across the seminiferous epithelium is crucial to spermatogenesis. Its disruption causes infertility. Signaling molecules, such as focal adhesion kinase, c-Yes, c-Src, and intercellular adhesion molecules 1 and 2, are involved in these events by regulating actin-based cytoskeleton via their action on actin-regulating proteins, endocytic vesicle-mediated protein trafficking, and adhesion protein complexes. We critically evaluate these findings and provide a hypothetical framework that regulates these events.
authors.affiliation: The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, New York, New York; and.
authors.forename: Xiang
authors.initials: X
authors.lastname: Xiao
authors.affiliation: The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, New York, New York; and.
authors.forename: Dolores D
authors.initials: DD
authors.lastname: Mruk
authors.affiliation: Department of Biology, Hong Kong Baptist University, Hong Kong, China.
authors.forename: Chris K C
authors.initials: CK
authors.lastname: Wong
authors.affiliation: The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, New York, New York; and Y-Cheng@popcbr.rockefeller.edu.
authors.forename: C Yan
authors.initials: CY
authors.lastname: Cheng
mesh_terms: D000818:Animals; D003599:Cytoskeleton / Q000502:physiology; D006801:Humans; D008297:Male; D010587:Phagocytosis / Q000502:physiology; D012670:Seminiferous Epithelium / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D013091:Spermatogenesis / Q000502:physiology*; D013094:Spermatozoa / Q000502:physiology*