title: [Evaluation of the impact of a training program on vitamin K antagonists (VKA) implemented by pharmacy students aiming at improving the knowledge of patients receiving vitamin K antagonists during their hospital clinical training course].
abstract: BACKGROUND
  We developed a training program for pharmacy students aiming at supporting patients receiving vitamin K antagonists (VKAs). The objective was to estimate how the program impacts VKA-treated patient knowledge acquisition and/or improvement on their anticoagulant treatment.
  
  
  METHODS
  Using dedicated tools, pharmacy students received education on VKA treatment. Once appointed to clinical wards of Assistance publique-Hôpitaux de Paris, they were in charge of evaluating patient's knowledge on VKA treatment before and after training. Evaluation was conducted using a face-to-face standardized interview (14-item questionnaire). A global score was calculated for each patient. An univariate and multivariate analysis was performed to identify potential variables influencing score result.
  
  
  RESULTS
  One hundred and seventy VKA-treated patients were recruited in seven hospitals for evaluation of their knowledge on VKA treatment and on clinical at risk situations. Before intervention, patients obtained an average score of 12.3±3.2 (maximum: 18). Factors significantly associated with the score were possession of a VKA information booklet, VKA treatment duration, treatment initiation and age. Fifty-two patients with a low score were further trained by the pharmacy student. After intervention, their initial score was improved significantly, from 9.9±3.3 to 13.5±2.3 (P<0.0001).
  
  
  CONCLUSIONS
  Increasing patient knowledge is a way to decrease the rate of adverse effects. This study demonstrates that patients with primary poor knowledge improved it significantly thanks to pharmacy students' intervention. This may contribute to lower the VKA-associated risk of adverse events and consequently to the improvement of patients quality of life and healthcare expenditures.
authors.affiliation: Service de pharmacie, hôpital Cochin, AP-HP, 27, rue du Faubourg-Saint-Jacques, 75679 Paris, France. Electronic address: ornella.conort@cch.aphp.fr.
authors.forename: O
authors.initials: O
authors.lastname: Conort
authors.affiliation: Service d'hématologie biologique, hôpital européen Georges-Pompidou, AP-HP, 75908 Paris, France; Inserm UMR-S-1140, faculté de pharmacie, université Paris Descartes, 75270 Paris, France.
authors.forename: V
authors.initials: V
authors.lastname: Siguret
authors.affiliation: Service de pharmacie, hôpital Robert-Debré, AP-HP, 75935 Paris, France; Pharmacie clinique, faculté de pharmacie, université Paris Descartes, 75270 Paris, France.
authors.forename: O
authors.initials: O
authors.lastname: Bourdon
authors.affiliation: Service de pharmacie, hôpital Saint-Antoine, AP-HP, 75571 Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Nazaraly
authors.affiliation: Service de pharmacie, hôpital Saint-Antoine, AP-HP, 75571 Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Brignone
authors.affiliation: Service de pharmacie, hôpital Beaujon, AP-HP, 92110 Paris, France.
authors.forename: N
authors.initials: N
authors.lastname: Pons-Kerjean
authors.affiliation: Laboratoire de parasitologie, hôpital Bichat-Claude-Bernard, AP-HP, 75877 Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Houze
authors.affiliation: Service de pharmacie, hôpital Rothschild, AP-HP, 75012 Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Laribe Cage
authors.affiliation: Service de pharmacie, hôpitaux de Saint-Maurice, 94410 Saint-Maurice, France.
authors.forename: F
authors.initials: F
authors.lastname: Berthet
authors.affiliation: Département de biostatistiques, GH Pitié-Salpêtrière, AP-HP, 75651 Paris, France.
authors.forename: J-L
authors.initials: JL
authors.lastname: Golmard
authors.affiliation: Service de pharmacie, hôpital Robert-Debré, AP-HP, 75935 Paris, France; Pharmacie clinique, faculté de pharmacie, université Paris Descartes, 75270 Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Brion
authors.affiliation: Pharmacie clinique, faculté de pharmacie, université Paris Descartes, 75270 Paris, France; Service de pharmacie, GH Pitié-Salpêtrière, AP-HP, 75651 Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Tilleul
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D007397:Internship, Nonmedical; D008297:Male; D008875:Middle Aged; D010353:Patient Education as Topic / Q000379:methods*; D010361:Patients; D012306:Risk; D013339:Students, Pharmacy; D014812:Vitamin K / Q000037:antagonists & inhibitors*; D055815:Young Adult
chemical_list: D000925:Anticoagulants; D014812:Vitamin K
keywords: Accompagnement thérapeutique; Antagonistes de la vitamine K; Patient education; Pharmacy student; Vitamin K antagonists; Étudiant en pharmacie