title: Ruthenium-catalyzed N-alkylation of amines with alcohols under mild conditions using the borrowing hydrogen methodology.
abstract: Using a simple amino amide ligand, ruthenium-catalyzed one-pot alkylation of primary and secondary amines with simple alcohols was carried out under a wide range of conditions. Using the alcohol as solvent, alkylation was achieved under mild conditions, even as low as room temperature. Reactions occurred with high conversion and selectivity in many cases. Reactions can also be carried out at high temperatures in organic solvent with high selectivity using stoichiometric amounts of the alcohol.
authors.affiliation: Department of Chemistry, Georgetown Universiry , 37th Street & O Street NW, Washington, D.C. 20057, United States.
authors.forename: Arrey B
authors.initials: AB
authors.lastname: Enyong
authors.forename: Bahram
authors.initials: B
authors.lastname: Moasser
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000478:Alkylation; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D012428:Ruthenium / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry
chemical_list: D000438:Alcohols; D000588:Amines; D008024:Ligands; D012997:Solvents; D012428:Ruthenium; D006859:Hydrogen