title: [Clinical effect of endotracheal lavage with porcine pulmonary surfactant in term neonates with severe meconium aspiration syndrome].
abstract: OBJECTIVE
  To evaluate the clinical effect of endotracheal lavage with porcine pulmonary surfactant (PS) in term neonates with severe meconium aspiration syndrome (MAS).
  
  
  METHODS
  A total of 136 full-term infants with severe MAS who were admitted to the neonatal intensive care unit between January 2010 and June 2013 were randomly and equally divided into PS lavage and PS injection groups. In the PS lavage group, patients were treated with endotracheal lavage using 3-5 mL of diluted PS (12 mg/mL) each time, and the PS injection group was given PS by intratracheal injection at the first dose of 200 mg/kg. Blood gas, oxygenation index (OI), and PaO2/FiO2 (P/F) of the two groups were evaluated before and 2, 12, 24, and 48 hours after the treatment, and the duration of mechanical ventilation, complication rate, and cure rate were compared between the two groups.
  
  
  RESULTS
  Compared with the PS injection group, the PS lavage group had significantly higher PaO2 and P/F ration and significantly lower PaCO2 and OI at 12, 24, and 48 hours post-treatment (P<0.01), a significantly shorter duration of mechanical ventilation (P<0.01), a significantly smaller amount of PS (P<0.01), a significantly lower complication rate (P<0.05), and a significantly higher cure rate (97% vs 88%; P<0.05).
  
  
  CONCLUSIONS
  Compared with the intratracheal injection of PS, endotracheal lavage with diluted PS in term neonates with severe MAS can increase ventilation and oxygenation efficiency, shorten the duration of mechanical ventilation, reduce the complication rate, and increase the cure rate, indicating that this method is a safe and effective therapeutic strategy.
authors.affiliation: Department of Neonatology, Maternal and Child Health Hospital of Xiamen, Xiamen, Fujian 361000, China. xinzhufj@163.com.
authors.forename: Xin-Zhu
authors.initials: XZ
authors.lastname: Lin
authors.forename: Ji-Dong
authors.initials: JD
authors.lastname: Lai
authors.forename: Zhao-Yang
authors.initials: ZY
authors.lastname: Lan
authors.forename: Ya-Yin
authors.initials: YY
authors.lastname: Lin
mesh_terms: D000818:Animals; D006801:Humans; D007231:Infant, Newborn; D008471:Meconium Aspiration Syndrome / Q000188:drug therapy*; D011663:Pulmonary Surfactants / Q000008:administration & dosage*; D013552:Swine; D007507:Therapeutic Irrigation; D014132:Trachea
chemical_list: D011663:Pulmonary Surfactants