title: Sulfated quaternary amine lipids: a new class of inverse charge zwitterlipids.
abstract: We describe a new class of charge inverted zwitterionic sulfated lipids (AS) with a cationic quaternary amine anchored at the membrane interface and an anionic sulfate moiety extended into the aqueous phase. These lipids have exceptionally high transition temperatures and assemble into lipid aggregates when dispersed in aqueous solutions.
authors.affiliation: Department of Bioengineering and Therapeutic Sciences, School of Pharmacy, University of California San Francisco, San Francisco, CA 94143, USA.
authors.forename: Vincent J
authors.initials: VJ
authors.lastname: Venditto
authors.forename: Aaron
authors.initials: A
authors.lastname: Dolor
authors.forename: Aditya
authors.initials: A
authors.lastname: Kohli
authors.forename: Stefan
authors.initials: S
authors.lastname: Salentinig
authors.forename: Ben J
authors.initials: BJ
authors.lastname: Boyd
authors.forename: Francis C
authors.initials: FC
authors.lastname: Szoka
mesh_terms: D000588:Amines / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D008055:Lipids / Q000737:chemistry*; D013431:Sulfates / Q000737:chemistry*; D044366:Transition Temperature
chemical_list: D000588:Amines; D008055:Lipids; D013431:Sulfates