title: Ameliorating effects of combined curcumin and desferrioxamine on 6-OHDA-induced rat mode of Parkinson's disease.
abstract: The catecholaminergic neurotoxin 6-hydroxydopamine has been widely used to mimic the lesions in dopaminergic neurons to develop Parkinson's disease. The present study was aimed to evaluate the combined treatment with Curcumin and desferrioxamine (DFO) on 6-OHDA-induced neurotoxicity in the striatum of rats. Rat models with 6-OHDA-induced Parkinson's disease were treated with curcumin, DFO, or both and the effect of different treatments on dopamine level was examined. Moreover, the effect of different treatments on the levels of PCC, SOD, and GSH was also assessed to elucidate the underlying mechanisms of the neuroprotective effects of combined treatment of curcumin and DFO.
authors.affiliation: First Division of Neurology Department, Shaanxi Provincial People's Hospital, Xian, 710068, Shanxi, China, drhualv@163.com.
authors.forename: Hua
authors.initials: H
authors.lastname: Lv
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Shuqi
authors.initials: S
authors.lastname: Yu
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Li
authors.forename: Feng
authors.initials: F
authors.lastname: Jiang
authors.forename: Yu
authors.initials: Y
authors.lastname: Niu
authors.forename: Jie
authors.initials: J
authors.lastname: Yuan
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Cui
authors.forename: Wenxiu
authors.initials: W
authors.lastname: Wang
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003474:Curcumin / Q000494:pharmacology* / Q000627:therapeutic use; D003676:Deferoxamine / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D004347:Drug Interactions; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D016627:Oxidopamine / Q000633:toxicity*; D010300:Parkinson Disease / Q000188:drug therapy* / Q000209:etiology* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D018696:Neuroprotective Agents; D016627:Oxidopamine; D003474:Curcumin; D003676:Deferoxamine; D004298:Dopamine