title: Predictive values of antibodies against Pseudomonas aeruginosa in patients with cystic fibrosis one year after early eradication treatment.
abstract: BACKGROUND
  Patient dependent parameters to predict the long-term success of early eradication treatment of Pseudomonas aeruginosa have not yet been defined. For this purpose we assessed serum antibodies against P. aeruginosa in CF patients after early eradication treatment.
  
  
  METHODS
  Retrospective analyses of all consecutive patients with first P. aeruginosa detection 2005 to 2008. Absence of P. aeruginosa in the third year was defined as successful long-term eradication. Main outcome was to determine the predictive value of P. aeruginosa antibody results one year after initiation of early eradication treatment using antibodies against alkaline protease, elastase, and exotoxin A with regard to long-term success of eradication treatment.
  
  
  RESULTS
  Antibodies against P. aeruginosa correlated well with success of eradication; positive and negative predictive values after one year were 75% and 82% respectively. The incidence of new detection of P. aeruginosa was 8.5%. Long-term eradication was successful in 32 of 53 patients (60%).
  
  
  CONCLUSIONS
  Determination of serum antibodies against P. aeruginosa one year after first detection of P. aeruginosa and early eradication treatment can predict success of long-term eradication.
authors.affiliation: Children's University Hospital of the Ludwig-Maximilians-University of Munich, Lindwurmstr. 4, 80337 Munich, Germany. Electronic address: Matthias.Kappler@med.uni-muenchen.de.
authors.forename: Matthias
authors.initials: M
authors.lastname: Kappler
authors.affiliation: Children's University Hospital of the Ludwig-Maximilians-University of Munich, Lindwurmstr. 4, 80337 Munich, Germany. Electronic address: Felicitas.Nagel@med.uni-muenchen.de.
authors.forename: Felicitas
authors.initials: F
authors.lastname: Nagel
authors.affiliation: Children's University Hospital of the Ludwig-Maximilians-University of Munich, Lindwurmstr. 4, 80337 Munich, Germany. Electronic address: Maria.Feilcke@med.uni-muenchen.de.
authors.forename: Maria
authors.initials: M
authors.lastname: Feilcke
authors.affiliation: Children's University Hospital of the Ludwig-Maximilians-University of Munich, Lindwurmstr. 4, 80337 Munich, Germany. Electronic address: Gabriele.Heilig@med.uni-muenchen.de.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Heilig
authors.affiliation: Children's University Hospital of the Ludwig-Maximilians-University of Munich, Lindwurmstr. 4, 80337 Munich, Germany. Electronic address: Ann-Christin.Grimmelt@med.uni-muenchen.de.
authors.forename: Ann-Christin
authors.initials: AC
authors.lastname: Grimmelt
authors.affiliation: Children's University Hospital of the Ludwig-Maximilians-University of Munich, Lindwurmstr. 4, 80337 Munich, Germany. Electronic address: Ingo.Pawlita@med.uni-muenchen.de.
authors.forename: Ingo
authors.initials: I
authors.lastname: Pawlita
authors.affiliation: Children's University Hospital of the Ludwig-Maximilians-University of Munich, Lindwurmstr. 4, 80337 Munich, Germany. Electronic address: Armin.Irnstetter@med.uni-muenchen.de.
authors.forename: Armin
authors.initials: A
authors.lastname: Irnstetter
authors.affiliation: Children's University Hospital of the Ludwig-Maximilians-University of Munich, Lindwurmstr. 4, 80337 Munich, Germany. Electronic address: Jenna.Hildebrandt@med.uni-muenchen.de.
authors.forename: Jenna
authors.initials: J
authors.lastname: Hildebrandt
authors.affiliation: Children's University Hospital of the Ludwig-Maximilians-University of Munich, Lindwurmstr. 4, 80337 Munich, Germany. Electronic address: Helen.Burmester@med.uni-muenchen.de.
authors.forename: Helen
authors.initials: H
authors.lastname: Burmester
authors.affiliation: Children's University Hospital of the Ludwig-Maximilians-University of Munich, Lindwurmstr. 4, 80337 Munich, Germany. Electronic address: Caroline.Kroener@med.uni-muenchen.de.
authors.forename: Caroline
authors.initials: C
authors.lastname: Kröner
authors.affiliation: Children's University Hospital of the Ludwig-Maximilians-University of Munich, Lindwurmstr. 4, 80337 Munich, Germany. Electronic address: Matthias.Griese@med.uni-muenchen.de.
authors.forename: Matthias
authors.initials: M
authors.lastname: Griese
mesh_terms: D000293:Adolescent; D000907:Antibodies, Bacterial / Q000032:analysis*; D003550:Cystic Fibrosis / Q000188:drug therapy / Q000382:microbiology*; D005544:Forecasting; D006801:Humans; D011379:Prognosis; D011552:Pseudomonas Infections / Q000188:drug therapy / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000276:immunology* / Q000302:isolation & purification; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D000907:Antibodies, Bacterial
keywords: Cystic fibrosis; Prognostic value; Pseudomonas aeruginosa; Serum antibodies