title: Serum IL-17, IL-23, and TGF-β levels in type 1 and type 2 diabetic patients and age-matched healthy controls.
abstract: Type 1 diabetes is recognized as an autoimmune inflammatory disease and low grade inflammation is also observed in type 2 diabetic patients. Interleukin 17 (IL-17) is a new player in inflammation. Th17 cells, as the main source of IL-17, require transforming growth factor β (TGF-β) and interleukin 23 (IL-23). The aim of this study was to investigate serum IL-17, IL-23 and TGF-β levels in diabetic patients and controls. In this case-control study, serum levels of IL-17, IL-23, and TGF-β were measured in 24 type 1 diabetic patients and 30 healthy controls using the ELISA method. Simultaneously, the same methodology was used to compare serum concentration of these three cytokines in 38 type 2 diabetic patients and 40 healthy controls. There was no significant difference between serum levels of IL-17 and IL-23 cytokines between cases and controls. However, TGF-β was significantly lower in type 1 diabetic patients (P < 0.001). Serum IL-17 and IL-23 levels demonstrate no association with type 1 and type 2 diabetes, but, in line with previous studies, TGF-β levels were lower in type 1 diabetic patients.
authors.affiliation: Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran 1417755469, Iran ; Endocrinology and Metabolism Research Center (EMRC), Dr. Shariati Hospital, Tehran University of Medical Sciences, Tehran 1411413137, Iran ; Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran 1417613151, Iran.
authors.forename: Azam
authors.initials: A
authors.lastname: Roohi
authors.affiliation: Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran 1417613151, Iran.
authors.forename: Mina
authors.initials: M
authors.lastname: Tabrizi
authors.affiliation: Endocrinology and Metabolism Research Center (EMRC), Dr. Shariati Hospital, Tehran University of Medical Sciences, Tehran 1411413137, Iran.
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Abbasi
authors.affiliation: Endocrinology and Metabolism Research Center (EMRC), Dr. Shariati Hospital, Tehran University of Medical Sciences, Tehran 1411413137, Iran.
authors.forename: Asal
authors.initials: A
authors.lastname: Ataie-Jafari
authors.affiliation: Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran 1417613151, Iran.
authors.forename: Behrouz
authors.initials: B
authors.lastname: Nikbin
authors.affiliation: Endocrinology and Metabolism Research Center (EMRC), Dr. Shariati Hospital, Tehran University of Medical Sciences, Tehran 1411413137, Iran.
authors.forename: Bagher
authors.initials: B
authors.lastname: Larijani
authors.affiliation: Department of Public Health, Alborz University of Medical Sciences, Karaj 3139614171, Iran ; Department of Epidemiology, Iran University of Medical Sciences, Tehran 1449614535, Iran.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Qorbani
authors.affiliation: Department of Community and Preventive Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran 1417613151, Iran.
authors.forename: Alipasha
authors.initials: A
authors.lastname: Meysamie
authors.affiliation: Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari 4817844718, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Asgarian-Omran
authors.affiliation: Department of Pathology, Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran 1419733151, Iran.
authors.forename: Bahram
authors.initials: B
authors.lastname: Nikmanesh
authors.affiliation: Endocrinology and Metabolism Research Center (EMRC), Dr. Shariati Hospital, Tehran University of Medical Sciences, Tehran 1411413137, Iran.
authors.forename: Arezou
authors.initials: A
authors.lastname: Bajouri
authors.affiliation: Endocrinology and Metabolism Research Center (EMRC), Dr. Shariati Hospital, Tehran University of Medical Sciences, Tehran 1411413137, Iran.
authors.forename: Novin
authors.initials: N
authors.lastname: Shafiey
authors.affiliation: Farmanfarmaian Health Center, Tehran University of Medical Sciences, Tehran 1318618311, Iran.
authors.forename: Akram
authors.initials: A
authors.lastname: Maleki
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000473:pathology; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D020381:Interleukin-17 / Q000097:blood*; D053759:Interleukin-23 / Q000097:blood*; D008297:Male; D016212:Transforming Growth Factor beta / Q000097:blood*
chemical_list: D020381:Interleukin-17; D053759:Interleukin-23; D016212:Transforming Growth Factor beta