title: Mild aminoacylation of indoles and pyrroles through a three-component reaction with ynol ethers and sulfonyl azides.
abstract: An effective method for aminoacylation of indoles and pyrroles has been achieved. The transformation involves a multicomponent one-pot cascade reaction between indoles or pyrroles, ynol ethers, and sulfonyl azides, creating four different bonds regioselectively through N-sulfonyltriazole intermediates. The oxo-tryptamines and oxo-pyrroloethanamines are generated in moderate to high yields under mild reaction conditions.
authors.affiliation: Department of Chemistry, Emory University , 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
authors.forename: Joshua S
authors.initials: JS
authors.lastname: Alford
authors.forename: Huw M L
authors.initials: HM
authors.lastname: Davies