title: TNBC vs non-TNBC: A retrospective review of differences in mean age, family history, smoking history, and stage at diagnosis.
abstract: OBJECTIVE
  This study was designed to compare mean age, ethnicity, smoking history, family history of breast cancer, and stage at diagnosis in patients with triple-negative breast cancer (TNBC) vs non-TNBC at an inner city university program.
  
  
  METHODS
  We reviewed data in our tumor registry on patients seen between January 2000 and December 2005, and identified a total of 445 patients with various subtypes of breast cancers. Of these, 342 patients met our study criteria. Thirty-nine patients had TNBC and 303 had non-TNBC.
  
  
  RESULTS
  The mean age at diagnosis was 59.87 ± 15.67 years for TNBC and 60.09 ± 13.98 years for non-TNBC (P=.9272). TNBC was more common in black than in white patients (58.97% vs 35.90%; OR, 2.755; P=.004), and non-TNBC was more common in white than in black patients (57.76% vs 39.27%). There was not a statistically significant difference in past or present smoking between the TNBC and non-TNBC patients (20.51% vs 27.72%; P=.4385). Family history of breast cancer was not statistically related to TNBC status: a positive family history was reported in 30.77% of TNBC patients vs 33.33% of non-TNBC patients (P=.8384), no family history was reported in 51.28% of TNBC patients vs 51.82% of non-TNBC patients, and family history was unknown in 17.95% of TNBC patients vs 14.85% of non-TNBC patients. Pathologic stage at the time of diagnosis was as follows for TNBC vs non-TNBC patients: stage 0, 15.79% vs 11.37% (P=.4332); stage I, 34.21% vs 30.98% (P=.6890); stage II, 28.98% vs 37.25% (P=.3205); stage III, 18.42% vs 17.25% (P=.8591); and stage IV, 3.63% vs 3.14% (P=.8651).
  
  
  CONCLUSIONS
  We found that in our patient population, black women were significantly more likely to have TNBC than non-TNBC, and white women were more likely to have non-TNBC than TNBC.
authors.affiliation: University of Florida College of Medicine, Jacksonville, Florida.
authors.forename: Khurram
authors.initials: K
authors.lastname: Tariq
authors.affiliation: University of Florida College of Medicine, Jacksonville, Florida.
authors.forename: Arezo
authors.initials: A
authors.lastname: Farhangi
authors.affiliation: University of Florida College of Medicine, Jacksonville, Florida.
authors.forename: Fauzia
authors.initials: F
authors.lastname: Rana
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000473:pathology*; D005006:Ethnicity; D005190:Family; D005260:Female; D005431:Florida / Q000453:epidemiology / Q000208:ethnology; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D012042:Registries; D012189:Retrospective Studies; D012907:Smoking; D064726:Triple Negative Breast Neoplasms / Q000453:epidemiology* / Q000473:pathology*