title: Effect of glycemic control on intact parathyroid hormone level in end stage renal disease patients on maintenance hemodialysis.
abstract: OBJECTIVE
  We evaluated the relationship between iPTH levels and glycemic control in patients with diabetes and end stage renal disease (ESRD) on maintenance hemodialysis (MHD).
  
  
  METHODS
  The study included 98 subjects with ESRD and type 2 diabetes aged 30-75 years who were on MHD. These were divided into two groups--patients with HbA1c >7.0 (53 mmol/mol) (poor glycemic control group) and patients with HbA1c <7.0 (53 mmol/mol) (good glycemic control group). All patients had been on regular bicarbonate haemodialysis for more than 6 months using polysulfone membrane dialyzer; 4 h per episode 3 times/week, with a dialysis fluid of 3.0 mEq/L of calcium concentration. 1-α-(OH)D3 and calcium carbonate were used routinely in all patients. The contribution of each relevant biological parameter to serum iPTH level was assessed using multiple regression test.
  
  
  RESULTS
  Poor glycemic control was associated with reduced serum iPTH level and good glycemic control with higher serum iPTH. The serum HbA1c level was significantly correlated with the serum iPTH level (p=0.0003).
  
  
  CONCLUSIONS
  Glycemic control is a significant determinant of iPTH level in diabetic ESRD patients on MHD.
authors.affiliation: Department of Biochemistry, Medical College, 88, College Street, Kolkata 700073, West Bengal, India. Electronic address: subhasish.dan@gmail.com.
authors.forename: Subhasish
authors.initials: S
authors.lastname: Dan
authors.affiliation: Tejganj High School, Nutanganj, Burdwan 713103, West Bengal, India.
authors.forename: Papia
authors.initials: P
authors.lastname: Aditya
authors.affiliation: Department of Environmental Health Engineering, Sri Ramachandra University, Porur, Chennai 600116, Tamil Nadu, India.
authors.forename: Maitreya
authors.initials: M
authors.lastname: Samanta
authors.affiliation: Department of Biochemistry, Sri Ramachandra University, Porur, Chennai 600116, Tamil Nadu, India.
authors.forename: R
authors.initials: R
authors.lastname: Jothimalar
authors.affiliation: Department of Nephrology, Sri Ramachandra University, Porur, Chennai 600116, Tamil Nadu, India.
authors.forename: P
authors.initials: P
authors.lastname: Soundarajan
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000502:physiology*; D016723:Bone Remodeling / Q000502:physiology; D002118:Calcium / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D007194:India; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood* / Q000502:physiology*; D006435:Renal Dialysis
chemical_list: D001786:Blood Glucose; D002118:Calcium; D006442:Glycated Hemoglobin; D010281:Parathyroid Hormone; C517652:hemoglobin A1c protein, human
keywords: Intact parathyroid hormone; Maintenance hemodialysis; Type 2 diabetes mellitus