title: Microbe-Host Interactions are Positively and Negatively Regulated by Galectin-Glycan Interactions.
abstract: Microbe-host interactions are complex processes that are directly and indirectly regulated by a variety of factors, including microbe presentation of specific molecular signatures on the microbial surface, as well as host cell presentation of receptors that recognize these pathogen signatures. Cell surface glycans are one important class of microbial signatures that are recognized by a variety of host cell lectins. Host cell lectins that recognize microbial glycans include members of the galectin family of lectins that recognize specific glycan ligands on viruses, bacteria, fungi, and parasites. In this review, we will discuss the ways that the interactions of microbial glycans with host cell galectins positively and negatively regulate pathogen attachment, invasion, and survival, as well as regulate host responses that mitigate microbial pathogenesis.
authors.affiliation: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California Los Angeles , Los Angeles, CA , USA.
authors.forename: Linda G
authors.initials: LG
authors.lastname: Baum
authors.affiliation: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California Los Angeles , Los Angeles, CA , USA.
authors.forename: Omai B
authors.initials: OB
authors.lastname: Garner
authors.affiliation: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California Los Angeles , Los Angeles, CA , USA.
authors.forename: Katrin
authors.initials: K
authors.lastname: Schaefer
authors.affiliation: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California Los Angeles , Los Angeles, CA , USA ; Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at University of California Los Angeles , Los Angeles, CA , USA.
authors.forename: Benhur
authors.initials: B
authors.lastname: Lee
keywords: bacteria; cell surface glycans; galectin; microbial pathogen; virus