title: Four GABAergic interneurons impose feeding restraint in Drosophila.
abstract: Feeding is dynamically regulated by the palatability of the food source and the physiological needs of the animal. How consumption is controlled by external sensory cues and internal metabolic state remains under intense investigation. Here, we identify four GABAergic interneurons in the Drosophila brain that establish a central feeding threshold which is required to inhibit consumption. Inactivation of these cells results in indiscriminate and excessive intake of all compounds, independent of taste quality or nutritional state. Conversely, acute activation of these neurons suppresses consumption of water and nutrients. The output from these neurons is required to gate activity in motor neurons that control meal initiation and consumption. Thus, our study reveals a layer of inhibitory control in feeding circuits that is required to suppress a latent state of unrestricted and nonselective consumption.
authors.affiliation: Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, 16 Barker Hall, Berkeley, CA 94720, USA.
authors.forename: Allan-Hermann
authors.initials: AH
authors.lastname: Pool
authors.affiliation: Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, 16 Barker Hall, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, 16 Barker Hall, Berkeley, CA 94720, USA.
authors.forename: Pal
authors.initials: P
authors.lastname: Kvello
authors.affiliation: Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, 16 Barker Hall, Berkeley, CA 94720, USA.
authors.forename: Kevin
authors.initials: K
authors.lastname: Mann
authors.affiliation: Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, 16 Barker Hall, Berkeley, CA 94720, USA.
authors.forename: Samantha K
authors.initials: SK
authors.lastname: Cheung
authors.affiliation: Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, 16 Barker Hall, Berkeley, CA 94720, USA.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Gordon
authors.affiliation: Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, 16 Barker Hall, Berkeley, CA 94720, USA.
authors.forename: Liming
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, 16 Barker Hall, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, 16 Barker Hall, Berkeley, CA 94720, USA. Electronic address: kscott@berkeley.edu.
authors.forename: Kristin
authors.initials: K
authors.lastname: Scott
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D004330:Drosophila; D005247:Feeding Behavior / Q000502:physiology*; D005260:Female; D059330:GABAergic Neurons / Q000502:physiology*; D041981:Gastrointestinal Tract / Q000294:innervation / Q000502:physiology; D007395:Interneurons / Q000502:physiology*