title: [Role of miR-155 in pathogenesis of diffuse large B cell lymphoma and its possible mechanism].
abstract: Diffuse large B cell lymphoma (DLBCL) is the most common subtype of invasive non-Hodgkin's lymphoma (NHL), account for 30%-40% of NHL in adults, the 5-year survival rate is approximately 25%. Although there was a standard treatment to DLBCL today, approximately 50% of patients can not be cured. As a result, it is still a diligent direction of the researchers to understand the pathogenesis of DLBCL and to explore new effective treatment. Recently, the study of microRNA is a hot topic in biology, microRNAs are a class of small non-coding RNA that have emerged to regulate various of biological processes. MiR-155 is one of the most well-known oncogenic micro-RNA, miR-155 overexpression has been documented in a number of lymphoid neoplasms, extraordinarily in DLBCL. MiR-155 can promote the occurrence of lymphoma through various signaling pathways, such as the BMP/TGF-β and RhoA pathway, it is expected to become a new target for treatment of DLBCL. This article reviews the role and possible mechanisms of miR-155 in the pathogenesis of DLBCL.
authors.affiliation: Department of Hematology, The Second Hospital Affliated to Nanchang Universitor, Jiangxi Provincial Key Laboratory of Blood Deseases; Postgraduate School, Medical Department, Nanchang University, Nanchang 330006, Jiangxi Province, China.
authors.forename: Jin-Shu
authors.initials: JS
authors.lastname: Shi
authors.affiliation: Department of Hematology, The Second Hospital Affliated to Nanchang Universitor, Jiangxi Provincial Key Laboratory of Blood Deseases; Postgraduate School, Medical Department, Nanchang University, Nanchang 330006, Jiangxi Province, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Hematology, The Second Hospital Affliated to Nanchang Universitor, Jiangxi Provincial Key Laboratory of Blood Deseases. E-mail:jeniferjian@gmail.com.
authors.forename: Jian
authors.initials: J
authors.lastname: Li
mesh_terms: D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics / Q000378:metabolism*; D035683:MicroRNAs / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: C524942:MIRN155 microRNA, human; D035683:MicroRNAs