title: Impact of infectious diseases consultation on the management of Staphylococcus aureus bacteraemia in children.
abstract: OBJECTIVE
  Infectious diseases consultation (IDC) in adults with Staphylococcus aureus bacteraemia (SAB) has been shown to improve management and outcome. The aim of this study was to evaluate the impact of IDC on the management of SAB in children.
  
  
  METHODS
  Observational cohort study of children with SAB.
  
  
  METHODS
  Cambridge University Hospitals National Health Service (NHS) Foundation Trust, a large acute NHS Trust in the UK.
  
  
  METHODS
  All children with SAB admitted to the Cambridge University Hospitals NHS Foundation Trust between 16 July 2006 and 31 December 2012.
  
  
  METHODS
  Children with SAB between 2006 and 31 October 2009 were managed by routine clinical care (pre-IDC group) and data were collected retrospectively by case notes review. An IDC service for SAB was introduced in November 2009. All children with SAB were reviewed regularly and data were collected prospectively (IDC group) until 31 December 2012. Baseline characteristics, quality metrics and outcome were compared between the pre-IDC group and IDC group.
  
  
  RESULTS
  There were 66 episodes of SAB in 63 children-28 patients (30 episodes) in the pre-IDC group, and 35 patients (36 episodes) in the IDC group. The median age was 3.4 years (IQR 0.2-10.7 years). Patients in the IDC group were more likely to have echocardiography performed, a removable focus of infection identified and to receive a longer course of intravenous antimicrobial therapy. There were no differences in total duration of antibiotic therapy, duration of hospital admission or outcome at 30 or 90 days following onset of SAB.
  
  
  CONCLUSIONS
  IDC resulted in improvements in the investigation and management of SAB in children.
authors.affiliation: Department of Medicine, University of Cambridge, Cambridge, UK.
authors.forename: Rebecca B
authors.initials: RB
authors.lastname: Saunderson
authors.affiliation: Department of Medicine, University of Cambridge, Cambridge, UK Department of Microbiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK Public Health England, Clinical Microbiology and Public Health Laboratory, Cambridge, UK.
authors.forename: Theodore
authors.initials: T
authors.lastname: Gouliouris
authors.affiliation: Department of Medicine, University of Cambridge, Cambridge, UK Public Health England, Clinical Microbiology and Public Health Laboratory, Cambridge, UK.
authors.forename: Edward J
authors.identifier: http://orcid.org/0000-0001-5666-5990
authors.initials: EJ
authors.lastname: Cartwright
authors.affiliation: Department of Infectious Diseases, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
authors.forename: Emma J
authors.initials: EJ
authors.lastname: Nickerson
authors.affiliation: Department of Microbiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK Department of Infectious Diseases, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
authors.forename: Sani H
authors.initials: SH
authors.lastname: Aliyu
authors.affiliation: Department of Paediatrics, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
authors.forename: D Roddy
authors.initials: DR
authors.lastname: O'Donnell
authors.affiliation: Department of Paediatrics, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
authors.forename: Wilf
authors.initials: W
authors.lastname: Kelsall
authors.affiliation: Mahidol Oxford Research Unit, Mahidol University, Bangkok, Thailand.
authors.forename: D
authors.initials: D
authors.lastname: Limmathurotsakul
authors.affiliation: Department of Medicine, University of Cambridge, Cambridge, UK Department of Microbiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK Public Health England, Clinical Microbiology and Public Health Laboratory, Cambridge, UK Wellcome Trust Sanger Institute, Hinxton, UK.
authors.forename: Sharon J
authors.initials: SJ
authors.lastname: Peacock
authors.affiliation: Department of Medicine, University of Cambridge, Cambridge, UK Department of Microbiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK Public Health England, Clinical Microbiology and Public Health Laboratory, Cambridge, UK.
authors.forename: M Estée
authors.initials: ME
authors.lastname: Török
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016470:Bacteremia / Q000382:microbiology / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D004117:Dimethoate; D019468:Disease Management; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011379:Prognosis; D012017:Referral and Consultation; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000382:microbiology / Q000628:therapy*; D013211:Staphylococcus aureus / Q000302:isolation & purification*
chemical_list: D000900:Anti-Bacterial Agents; D004117:Dimethoate