title: Nerve growth factor novel dipeptide mimetic GK-2 selectively activates TrkA postreceptor signaling pathways and does not cause adverse effects of native neurotrophin.
authors.affiliation: Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, ul. Baltiiskaya 8, Moscow, 125315, Russia, tata-sosnovka@mail.ru.
authors.forename: T A
authors.initials: TA
authors.lastname: Gudasheva
authors.forename: T A
authors.initials: TA
authors.lastname: Antipova
authors.forename: M A
authors.initials: MA
authors.lastname: Konstantinopolsky
authors.forename: P Yu
authors.initials: PY
authors.lastname: Povarnina
authors.forename: S B
authors.initials: SB
authors.lastname: Seredenin
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D002460:Cell Line; D002867:Chromones / Q000494:pharmacology; D004151:Dipeptides / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D020935:MAP Kinase Signaling System / Q000187:drug effects; D051379:Mice; D009025:Morpholines / Q000494:pharmacology; D020932:Nerve Growth Factor / Q000378:metabolism; D009414:Nerve Growth Factors / Q000378:metabolism*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology; D017288:Pain Threshold / Q000187:drug effects; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D000081082:Phosphoinositide-3 Kinase Inhibitors; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D051381:Rats; D020917:Receptor, trkA / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D002867:Chromones; D004151:Dipeptides; D004791:Enzyme Inhibitors; D009025:Morpholines; D020932:Nerve Growth Factor; D009414:Nerve Growth Factors; D018696:Neuroprotective Agents; D019869:Phosphatidylinositol 3-Kinases; D000081082:Phosphoinositide-3 Kinase Inhibitors; D051057:Proto-Oncogene Proteins c-akt; D020917:Receptor, trkA; C572946:bis(N-succinyl-glutamyllysin)hexamethylenediamine; C085911:2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one