title: miR in CLL: more than mere markers of prognosis?
abstract: In this issue of Blood, Mraz et al show that microRNA-150 (miR-150) is the most abundantly expressed miR in chronic lymphocytic leukemia (CLL) and affects the threshold for B-cell receptor (BCR) signaling by repressing expression levels of GAB1 and FOXP1. This functional link might explain the described association between expression levels of miR-150 and prognosis.
authors.affiliation: ACADEMIC MEDICAL CENTER, UNIVERSITY OF AMSTERDAM.
authors.forename: Arnon P
authors.initials: AP
authors.lastname: Kater
authors.affiliation: ACADEMIC MEDICAL CENTER, UNIVERSITY OF AMSTERDAM.
authors.forename: Eric
authors.initials: E
authors.lastname: Eldering
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000096:biosynthesis*; D005260:Female; D051858:Forkhead Transcription Factors / Q000096:biosynthesis*; D015973:Gene Expression Regulation, Leukemic / Q000235:genetics*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D011947:Receptors, Antigen, B-Cell / Q000378:metabolism*; D012097:Repressor Proteins / Q000096:biosynthesis*; D015398:Signal Transduction
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D051858:Forkhead Transcription Factors; D035683:MicroRNAs; D011947:Receptors, Antigen, B-Cell; D012097:Repressor Proteins; C486626:FOXP1 protein, human; C098587:GAB1 protein, human; C533097:MIR150, human