title: X-ray micromodulated luminescence tomography in dual-cone geometry.
abstract: We propose a scanning method utilizing dual-cone beams of x-rays to induce luminescence from nanophosphors and reconstruct the three-dimensional distribution of these particles in a biological sample or a small animal. For this purpose, x-rays are focused through a polycapillary lens onto a spot of a few micrometers in size. Such x-ray scanning can be point-wise performed to acquire photon emission data on an object surface. The x-ray-induced luminescence data allow for reliable image reconstruction with high spatial resolution and large imaging depth. We describe several numerical simulation studies to demonstrate the feasibility and merits of the proposed approach.
authors.affiliation: Rensselaer Polytechnic Institute, Department of Biomedical Engineering, 110 8th Street, Troy, New York 12180.
authors.forename: Wenxiang
authors.initials: W
authors.lastname: Cong
authors.affiliation: University of Georgia, Department of Physics and Astronomy, Athens, Georgia 30602.
authors.forename: Zhengwei
authors.initials: Z
authors.lastname: Pan
authors.affiliation: GE Global Research Center, 1 Research Circle, Niskayuna, New York 12309.
authors.forename: Robert
authors.initials: R
authors.lastname: Filkins
authors.affiliation: GE Global Research Center, 1 Research Circle, Niskayuna, New York 12309.
authors.forename: Alok
authors.initials: A
authors.lastname: Srivastava
authors.affiliation: GE Global Research Center, 1 Research Circle, Niskayuna, New York 12309.
authors.forename: Nadeem
authors.initials: N
authors.lastname: Ishaque
authors.affiliation: Purdue University, Department of Mathematics, 150N University Street, West Lafayette, Indiana 47907.
authors.forename: Plamen
authors.initials: P
authors.lastname: Stefanov
authors.affiliation: Rensselaer Polytechnic Institute, Department of Biomedical Engineering, 110 8th Street, Troy, New York 12180.
authors.forename: Ge
authors.initials: G
authors.lastname: Wang
mesh_terms: D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging; D003198:Computer Simulation; D005456:Fluorescent Dyes; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D051379:Mice; D053758:Nanoparticles; D061848:Optical Imaging / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D005456:Fluorescent Dyes