title: The ratio of estimated average glucose to fasting plasma glucose level is superior to glycated albumin, hemoglobin A1c, fructosamine, and GA/A1c ratio for assessing β-cell function in childhood diabetes.
abstract: OBJECTIVE
  This study investigated the use of the estimated average glucose to fasting plasma glucose ratio (eAG/fPG ratio) to screen for β-cell function in pediatric diabetes.
  
  
  METHODS
  Glycated hemoglobin (HbA1c), glycated albumin (GA), fructosamine, insulin, and C-peptide levels were measured. The ratio of GA to HbA1c (GA/A1c ratio) was calculated, and the homeostasis model assessment of β-cell function (HOMA-β) was determined.
  
  
  RESULTS
  Median values of C-peptide, insulin, and HOMA-β levels were significantly higher in patients with an increased eAG/fPG ratio than in those with a decreased eAG/fPG ratio. C-peptide and HOMA-β levels were more closely correlated with the eAG/fPG ratio than with GA, HbA1c, the GA/A1c ratio, and fructosamine. In contrast, body mass index was significantly associated with GA, GA/A1c ratio, and fructosamine, but not with the eAG/fPG ratio and HbA1c levels. To test the diagnostic accuracies of the eAG/fPG ratio for identifying HOMA-β>30.0% in patients with type 2 diabetes, the area under the ROC curve of the eAG/fPG ratio was significantly larger than that of the GA/A1c ratio [0.877 (95% CI, 0.780-0.942) versus 0.775 (95% CI, 0.664-0.865), P=0.039].
  
  
  CONCLUSIONS
  A measurement of the eAG/fPG ratio may provide helpful information for assessing β-cell function in pediatric patients with diabetes.
authors.affiliation: Department of Pediatrics, College of Medicine, Inha University, Incheon, Republic of Korea.
authors.forename: Ji Eun
authors.initials: JE
authors.lastname: Lee
authors.affiliation: Department of Pediatrics, College of Medicine, Inha University, Incheon, Republic of Korea.
authors.forename: Ji Woo
authors.initials: JW
authors.lastname: Lee
authors.affiliation: School of Medicine, University of Tsukuba, Ibaraki, Japan.
authors.forename: Tatsuyoshi
authors.initials: T
authors.lastname: Fujii
authors.affiliation: Department of Electrical Engineering and Bioscience, Waseda University, Tokyo, Japan.
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Fujii
authors.affiliation: Department of Laboratory Medicine, Inha University Hospital, College of Medicine, Inha University, 7-206 Shinheung-dong 3-Ga Jung-gu, Incheon 400-711, Republic of Korea.
authors.forename: Jong Weon
authors.initials: JW
authors.lastname: Choi
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose; D002096:C-Peptide / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000473:pathology; D005215:Fasting; D005260:Female; D019270:Fructosamine / Q000097:blood; D005947:Glucose / Q000378:metabolism*; D006442:Glycated Hemoglobin / Q000378:metabolism*; D017127:Glycation End Products, Advanced; D006801:Humans; D007328:Insulin / Q000097:blood; D050417:Insulin-Secreting Cells / Q000378:metabolism / Q000473:pathology; D008297:Male; D012709:Serum Albumin / Q000378:metabolism*; D055815:Young Adult; D000093423:Glycated Serum Albumin
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D019270:Fructosamine; D005947:Glucose; D006442:Glycated Hemoglobin; D017127:Glycation End Products, Advanced; D007328:Insulin; D012709:Serum Albumin; D000093423:Glycated Serum Albumin; C517652:hemoglobin A1c protein, human