title: Impact of Inflammatory Cytokines on Effector and Memory CD8+ T Cells.
abstract: Inflammatory cytokines have long been recognized to produce potent APCs to elicit robust T cell responses for protective immunity. The impact of inflammatory cytokine signaling directly on T cells, however, has only recently been appreciated. Although much remains to be learned, the CD8 T cell field has made considerable strides in understanding the effects of inflammatory cytokines throughout the CD8 T cell response. Key findings first identified IL-12 and type I interferons as "signal 3" cytokines, emphasizing their importance in generating optimal CD8 T cell responses. Separate investigations revealed another inflammatory cytokine, IL-15, to play a critical role in memory CD8 T cell maintenance. These early studies highlighted potential regulators of CD8 T cells, but were unable to provide mechanistic insight into how these inflammatory cytokines enhanced CD8 T cell-mediated immunity. Here, we describe the mechanistic advances that have been made in our lab regarding the role of "signal 3" cytokines and IL-15 in optimizing effector and memory CD8 T cell number and function. Furthermore, we assess initial progress on the role of cytokines, such as TGF-β, in generation of recently described resident memory CD8 T cell populations.
authors.affiliation: Interdisciplinary Program in Immunology, University of Iowa , Iowa City, IA , USA.
authors.forename: Marie T
authors.initials: MT
authors.lastname: Kim
authors.affiliation: Interdisciplinary Program in Immunology, University of Iowa , Iowa City, IA , USA ; Department of Microbiology, University of Iowa , Iowa City, IA , USA ; Department of Pathology, University of Iowa , Iowa City, IA , USA.
authors.forename: John T
authors.initials: JT
authors.lastname: Harty
keywords: CD8 T cells; cytokines; effector; memory; resident memory; signal 3