title: Delayed leukoencephalopathy after carbon monoxide poisoning presenting as subacute dementia.
abstract: We herein report the case of a 65-year-old woman who presented with the subacute onset of dementia and subsequently developed abnormal behavior and a gait disturbance. Her condition transiently improved; however, within one month, she became drowsy and poorly responsive, with limb chorea and urinary incontinence. Her history of frequently using charcoal led us to diagnose her with carbon monoxide (CO) poisoning. The findings of this case and a literature review suggest that subacute dementia due to CO poisoning recovers late, after a year or more, in patients above sixty years of age, and both hyperbaric oxygen and corticosteroid pulse therapy should be considered in such cases, even after one month.
authors.affiliation: Department of Neurology, Mitsui Memorial Hospital, Japan.
authors.forename: Yu
authors.initials: Y
authors.lastname: Mizuno
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Sakurai
authors.forename: Izumi
authors.initials: I
authors.lastname: Sugimoto
authors.forename: Keiko
authors.initials: K
authors.lastname: Ichinose
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Ishihara
authors.forename: Nobuo
authors.initials: N
authors.lastname: Sanjo
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Mizusawa
authors.forename: Toru
authors.initials: T
authors.lastname: Mannen
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002249:Carbon Monoxide Poisoning / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D003545:Cysteine / Q000031:analogs & derivatives; D003704:Dementia / Q000209:etiology*; D005260:Female; D005684:Gait; D006801:Humans; D006931:Hyperbaric Oxygenation; D056784:Leukoencephalopathies / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D009069:Movement Disorders / Q000209:etiology; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000305:Adrenal Cortex Hormones; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C059659:technetium Tc 99m bicisate; D003545:Cysteine