title: A novel restricted diffusion model of evoked dopamine.
abstract: In vivo fast-scan cyclic voltammetry provides high-fidelity recordings of electrically evoked dopamine release in the rat striatum. The evoked responses are suitable targets for numerical modeling because the frequency and duration of the stimulus are exactly known. Responses recorded in the dorsal and ventral striatum of the rat do not bear out the predictions of a numerical model that assumes the presence of a diffusion gap interposed between the recording electrode and nearby dopamine terminals. Recent findings, however, suggest that dopamine may be subject to restricted diffusion processes in brain extracellular space. A numerical model cast to account for restricted diffusion produces excellent agreement between simulated and observed responses recorded under a broad range of anatomical, stimulus, and pharmacological conditions. The numerical model requires four, and in some cases only three, adjustable parameters and produces meaningful kinetic parameter values.
authors.affiliation: Department of Chemistry, University of Pittsburgh , Pittsburgh, Pennsylvania 15260, United States.
authors.forename: Seth H
authors.initials: SH
authors.lastname: Walters
authors.forename: I Mitch
authors.initials: IM
authors.lastname: Taylor
authors.forename: Zhan
authors.initials: Z
authors.lastname: Shu
authors.forename: Adrian C
authors.initials: AC
authors.lastname: Michael
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D003198:Computer Simulation; D004298:Dopamine / Q000378:metabolism*; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology; D004558:Electric Stimulation; D008954:Models, Biological; D009627:Nomifensine / Q000494:pharmacology; D051381:Rats
chemical_list: D018765:Dopamine Uptake Inhibitors; D009627:Nomifensine; D004298:Dopamine
keywords: Model; diffusion; domain; dopamine; restricted diffusion; voltammetry