title: Anxiety disorders are associated with quality of life impairment in patients with insulin-dependent type 2 diabetes: a case-control study.
abstract: OBJECTIVE
  To assess the presence of anxiety disorders and quality of life in patients with insulin-dependent type 2 diabetes.
  
  
  METHODS
  Case-control study of 996 patients with type 2 diabetes and 2,145 individuals without diabetes. The sole inclusion criterion for the case group was insulin-dependent type 2 diabetes. We compared the case and control groups for sociodemographic variables, laboratory and clinical data, and presence of anxiety disorders. Quality of life was evaluated using the WHOQOL-BREF instrument, and the prevalence of anxiety disorder was evaluated by the Mini International Neuropsychiatric Interview (MINI).
  
  
  RESULTS
  Patients with diabetes had a higher prevalence of generalized anxiety disorder, panic disorder, and obsessive-compulsive disorder. The presence of these disorders in combination with type 2 diabetes was associated with worse quality of life in the physical, social, psychological, and environmental domains.
  
  
  CONCLUSIONS
  This study demonstrates the importance of diagnosing and treating anxiety disorders in patients with diabetes, so as to prevent more serious complications associated with these comorbidities.
authors.affiliation: Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense (UNESC), Criciúma, SC, Brazil.
authors.forename: Maria Augusta B dos
authors.initials: MA
authors.lastname: Santos
authors.affiliation: Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense (UNESC), Criciúma, SC, Brazil.
authors.forename: Luciane B
authors.initials: LB
authors.lastname: Ceretta
authors.affiliation: Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense (UNESC), Criciúma, SC, Brazil.
authors.forename: Gislaine Z
authors.initials: GZ
authors.lastname: Réus
authors.affiliation: Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense (UNESC), Criciúma, SC, Brazil.
authors.forename: Helena M
authors.initials: HM
authors.lastname: Abelaira
authors.affiliation: Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense (UNESC), Criciúma, SC, Brazil.
authors.forename: Luciano K
authors.initials: LK
authors.lastname: Jornada
authors.affiliation: Department of Nursing, UNESC, Criciúma, SC, Brazil.
authors.forename: Mágada T
authors.initials: MT
authors.lastname: Schwalm
authors.affiliation: Department of Nursing, UNESC, Criciúma, SC, Brazil.
authors.forename: Morgana V
authors.initials: MV
authors.lastname: Neotti
authors.affiliation: Laboratory of Experimental Pathophysiology and National Science and Technology Institute for Translational Medicine (INCT-TM), UNESC, Criciúma, SC, Brazil.
authors.forename: Cristiane D
authors.initials: CD
authors.lastname: Tomazzi
authors.affiliation: Department of Nursing, UNESC, Criciúma, SC, Brazil.
authors.forename: Karina G
authors.initials: KG
authors.lastname: Gulbis
authors.affiliation: Department of Dentistry, UNESC, Criciúma, SC, Brazil.
authors.forename: Renan A
authors.initials: RA
authors.lastname: Ceretta
authors.affiliation: Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense (UNESC), Criciúma, SC, Brazil.
authors.forename: João
authors.initials: J
authors.lastname: Quevedo
mesh_terms: D001008:Anxiety Disorders / Q000503:physiopathology / Q000523:psychology*; D016022:Case-Control Studies; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology / Q000523:psychology*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D017533:Marital Status; D015999:Multivariate Analysis; D011788:Quality of Life / Q000523:psychology*; D012931:Social Environment; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin