title: White pepper and piperine have different effects on pharmacokinetics of puerarin in rats.
abstract: This study attempted to explore the effects of white pepper and its major component piperine on puerarin administered to rats. Pharmacokinetic parameters of puerarin in rats were determined by oral administration (400 mg/kg) or intravenous injection (40 mg/kg) of puerarin, pretreated with or without white pepper and piperine given orally. Compared to the control group given oral puerarin only, the combined use of piperine (10 or 20 mg/kg) increased the C max of puerarin by 1.30-fold or 1.64-fold and the AUC0-∞ by 133% or 157%, respectively. In contrast, coadministration of white pepper (125 or 250 mg/kg) decreased oral absorption of puerarin to 83% or 74%, respectively. On the other hand, pretreatment with piperine orally did not alter the intravenous pharmacokinetics of puerarin, while the AUC of puerarin after intravenous administration was increased by pretreatment with white pepper. The results indicate that pretreatment with piperine or pepper exerts different effects on pharmacokinetics of puerarin administrated via intragastric and intravenous routes. Therefore, it is suggested that the combined application of piperine or white pepper with puerarin should be carefully monitored for potential diet-drug interactions.
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Waihuandong Road No. 232, Guangzhou Higher Education Mega Center, Guangzhou 510006, China.
authors.forename: Yong-Zhuo
authors.initials: YZ
authors.lastname: Liang
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Waihuandong Road No. 232, Guangzhou Higher Education Mega Center, Guangzhou 510006, China.
authors.forename: Hai-Ming
authors.initials: HM
authors.lastname: Chen
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Waihuandong Road No. 232, Guangzhou Higher Education Mega Center, Guangzhou 510006, China.
authors.forename: Zu-Qing
authors.initials: ZQ
authors.lastname: Su
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Waihuandong Road No. 232, Guangzhou Higher Education Mega Center, Guangzhou 510006, China.
authors.forename: Shao-Zhen
authors.initials: SZ
authors.lastname: Hou
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Waihuandong Road No. 232, Guangzhou Higher Education Mega Center, Guangzhou 510006, China.
authors.forename: Xiao-Ying
authors.initials: XY
authors.lastname: Chen
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Waihuandong Road No. 232, Guangzhou Higher Education Mega Center, Guangzhou 510006, China.
authors.forename: Yi-Feng
authors.initials: YF
authors.lastname: Zheng
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Waihuandong Road No. 232, Guangzhou Higher Education Mega Center, Guangzhou 510006, China.
authors.forename: Yu-Cui
authors.initials: YC
authors.lastname: Li
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Waihuandong Road No. 232, Guangzhou Higher Education Mega Center, Guangzhou 510006, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Lin
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Waihuandong Road No. 232, Guangzhou Higher Education Mega Center, Guangzhou 510006, China.
authors.forename: Janis Ya-Xian
authors.initials: JY
authors.lastname: Zhan
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Waihuandong Road No. 232, Guangzhou Higher Education Mega Center, Guangzhou 510006, China.
authors.forename: Zi-Ren
authors.initials: ZR
authors.lastname: Su
authors.affiliation: Laboratory Animal Center, Guangzhou University of Chinese Medicine, Waihuandong Road No. 232, Guangzhou Higher Education Mega Center, Guangzhou 510006, China.
authors.forename: Lu-Di
authors.initials: LD
authors.lastname: Fu