title: [A case report of malignant lymphoma receiving infliximab therapy with Behçet's disease].
abstract: BACKGROUND
  To report a case of malignant lymphoma occurring in Behçet's disease (BD) with infliximab therapy.
  
  
  METHODS
  A 62-year-old man was diagnosed with BD in 1997. Despite treatment with colchicine, cyclosporine and prednisolone, he had frequent bilateral posterior ocular attacks. He was started on infliximab in August 2007 and for 6 months had no ocular attacks. Cyclosporine was therefore reduced. After 4 years of infliximab administration, he had neither ocular attacks nor general symptoms. However, he had general malaise and weight loss from the end of March 2012. Peripheral blood examination showed abnormal cells, so we terminated the infliximab. Bone marrow aspiration showed diffuse proliferation of medium to large lymphoid cells, and the histological diagnosis was diffuse large B-cell lymphoma. He was treated with 8 cycles of chemotherapy and 4 times intrathecal chemotherapy, and is now in remission. After termination of infliximab, he had no further ocular attacks.
  
  
  CONCLUSIONS
  Although malignant lymphoma associated with BD is rare, attending ophthalmologists need to keep it in mind.
authors.forename: Koh-Hei
authors.initials: KH
authors.lastname: Sonoda
authors.forename: Takako
authors.initials: T
authors.lastname: Fukuhara
authors.forename: Horoshi
authors.initials: H
authors.lastname: Yoshikawa
authors.forename: Atsunobu
authors.initials: A
authors.lastname: Takeda
authors.forename: Takeru
authors.initials: T
authors.lastname: Yoshimura
authors.forename: Mitsuteru
authors.initials: M
authors.lastname: Akahoshi
authors.forename: Hirotake
authors.initials: H
authors.lastname: Kusumoto
authors.forename: Kentaro
authors.initials: K
authors.lastname: Kohno
authors.forename: Koji
authors.initials: K
authors.lastname: Kato
authors.forename: Koichi
authors.initials: K
authors.lastname: Akashi
authors.forename: Kenichi
authors.initials: K
authors.lastname: Kohashi
authors.forename: Shinichi
authors.initials: S
authors.lastname: Aijima
authors.forename: Kenichi
authors.initials: K
authors.lastname: Namba
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Ishibashi
mesh_terms: D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D001528:Behcet Syndrome / Q000188:drug therapy*; D006801:Humans; D000069285:Infliximab; D016403:Lymphoma, Large B-Cell, Diffuse / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged
chemical_list: D000911:Antibodies, Monoclonal; D000069285:Infliximab