title: Efficacy of selected treadmill training programme on oxidative stress in adolescents with Down syndrome.
abstract: The aim of this study was to assess the efficacy of an electronic treadmill exercise training programme on malondialdehyde (MDA) as a marker for lipid peroxidation and the antioxidant enzyme glutathione peroxidase (GPx) in adolescents with Down syndrome. The study was carried out on 30 adolescent males with Down syndrome, ranging in age from 15 to 18 years, with 30 healthy subjects as a control group. Clinical examination, anthropometric measurements and determination of GPx activity and MDA before and after exercise were done. A treadmill training programme was performed for 12 weeks. Our data showed a significant increase in GPx activity and decrease in serum level of MDA in Down syndrome individuals after treadmill exercise for 3 months. Exercise promotion for adolescents with Down syndrome requires attention to motivators and facilitators of exercise adherence as it may limit risk of increased neurological consequences associated with oxidative stress and improve quality of life.
authors.affiliation: Department of Research on Children with Special Needs, National Research Center, Cairo, Egypt.
authors.forename: N A
authors.initials: NA
authors.lastname: Meguid
authors.affiliation: Department of Physical Therapy for Disturbances of Growth and Development and its Surgery in Pediatrics, Faculty of Physical Therapy, Cairo University, Cairo, Egypt.
authors.forename: A M
authors.initials: AM
authors.lastname: Eltohamy
authors.affiliation: Department of Research on Children with Special Needs, National Research Center, Cairo, Egypt.
authors.forename: M
authors.initials: M
authors.lastname: Anwar
authors.affiliation: Department of Research on Children with Special Needs, National Research Center, Cairo, Egypt.
authors.forename: A F
authors.initials: AF
authors.lastname: Hashish
authors.affiliation: Department of Research on Children with Special Needs, National Research Center, Cairo, Egypt.
authors.forename: A
authors.initials: A
authors.lastname: Elnahry