title: Diagnostic accuracies of sialography and salivary ultrasonography in Sjögren's syndrome patients: a meta-analysis.
abstract: OBJECTIVE
  The purpose of this study was to compare the diagnostic performance of sialography and salivary ultrasonography (US) for Sjögren's syndrome (SS) patients.
  
  
  METHODS
  We searched Medline, Embase, and the Cochran library, and performed two meta-analyses on the diagnostic accuracy of sialography and salivary US in SS patients.
  
  
  RESULTS
  A total of six studies including 488 patients and 447 controls from two European and four Asian studies were available for the meta-analysis. The pooled sensitivity and specificity of sialography were 80.0% (95% confidence interval [CI] 76.4-83.2) and 89.0% (85.8-91.8), respectively, and 77.4 (73.7-80.9) and 81.5 (77.6-85.0) for US, respectively. For sialography, the PLR, NLR, and DOR were 9.296 (4.200-20.57), 0.228 (0.170-0.305), and 46.51 (16.14-134.0), respectively, and for US were 4.631 (2.707-7.864), 0.302 (0.226-0.403), and 17.48 (10.03-30.45), respectively. The area under the curve (AUC) of sialography was 0.824, and the Q* index was 0.757, while the AUC of US was 0.864, and its Q* index was 0.794, indicating that the diagnostic accuracy of US is comparable with sialography in SS patients. A subgroup meta-analysis according to the diagnostic criteria did not change the overall diagnostic accuracy.
  
  
  CONCLUSIONS
  Our meta-analysis of published studies demonstrates that the diagnostic accuracy of salivary US is comparable with sialography in SS patients.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea. gsong@kumc.or.kr.
authors.forename: Gwan Gyu
authors.initials: GG
authors.lastname: Song
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Lee
mesh_terms: D019540:Area Under Curve; D006801:Humans; D011237:Predictive Value of Tests; D011379:Prognosis; D012372:ROC Curve; D015203:Reproducibility of Results; D012469:Salivary Glands / Q000000981:diagnostic imaging*; D012796:Sialography; D012859:Sjogren's Syndrome / Q000175:diagnosis* / Q000000981:diagnostic imaging; D014463:Ultrasonography