title: Electrospun PVP-indomethacin constituents for transdermal dressings and drug delivery devices.
abstract: A method in layering dressings with a superficial active layer of sub-micrometer scaled fibrous structures is demonstrated. For this, polyvinylpyrolidone (PVP)-indomethacin (INDO) fibres (5% w/v PVP, 5% w/w indomethacin, using a 50:50 ethanol-methanol solvent system) were produced at different flow rates (50 μL/min and 100 μL/min) via a modified electrospinning device head (applied voltage varied between 15 ± 2 kV). We further assessed these structures for their morphological, physical and chemical properties using SEM, AFM, DSC, XRD, FTIR and HPLC-UV. The average diameter of the resulting 3D (ca. 500 nm in height) PVP-INDO fibres produced at 50 μL/min flow rate was 2.58 ± 0.30 μm, while an almost two-fold increase in the diameter was observed (5.22 ± 0.83 μm) when the flow rate was doubled. However, both of these diameters were appreciably smaller than the existing dressing fibres (ca. 30 μm), which were visible even when layered with the active spun fibres. Indomethacin was incorporated in the amorphous state. The encapsulation efficiency was 75% w/w, with complete drug release in 45 min. The advantages are the ease of fabrication and deposition onto any existing normal or functionalised dressing (retaining the original fabric functionality), elimination of topical product issues (application, storage and transport), rapid release of active and controlled loading of drug content (fibre layer).
authors.affiliation: School of Pharmacy and Biomedical Sciences, St. Michaels Building, University of Portsmouth, White Swan Road, Portsmouth PO1 2DT, UK.
authors.forename: Manoochehr
authors.initials: M
authors.lastname: Rasekh
authors.affiliation: Aristotle University of Thessaloniki, School of Pharmacy, Department of Pharmaceutical Technology, Thessaloniki GR-54124, Greece.
authors.forename: Christina
authors.initials: C
authors.lastname: Karavasili
authors.affiliation: Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.
authors.forename: Yi Ling
authors.initials: YL
authors.lastname: Soong
authors.affiliation: Department of Materials Science, University of Patras, Patras, Greece; Foundation for Research and Technology Hellas, Institute of Chemical Engineering and High Temperature Chemical Processes, Patras, Greece.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Bouropoulos
authors.affiliation: School of Allied Health Sciences, De Montfort University, Leicester LE1 9BH, UK.
authors.forename: Mhairi
authors.initials: M
authors.lastname: Morris
authors.affiliation: Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.
authors.forename: David
authors.initials: D
authors.lastname: Armitage
authors.affiliation: Department of Materials Science and Engineering, Zhejiang University, Zheda Road, Hangzhou 310027, PR China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.affiliation: Aristotle University of Thessaloniki, School of Pharmacy, Department of Pharmaceutical Technology, Thessaloniki GR-54124, Greece. Electronic address: dfatouro@pharm.auth.gr.
authors.forename: Dimitrios G
authors.initials: DG
authors.lastname: Fatouros
authors.affiliation: Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.
authors.forename: Zeeshan
authors.initials: Z
authors.lastname: Ahmad
mesh_terms: D000279:Administration, Cutaneous; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry*; D001458:Bandages; D002152:Calorimetry, Differential Scanning; D004339:Drug Compounding / Q000379:methods; D016503:Drug Delivery Systems; D007213:Indomethacin / Q000008:administration & dosage / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D011205:Povidone / Q000008:administration & dosage / Q000737:chemistry*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011205:Povidone; D007213:Indomethacin
keywords: Biomaterials; Electrospinning; Fibres; Poorly soluble drugs; Wound healing