title: Enhanced immune activation linked to endotoxemia in HIV-1 seronegative MSM.
abstract: This study assessed cellular and soluble markers of immune activation in HIV-1 seronegative MSM. MSM immune profiles were characterized by an increased expression of CD57 on T cells and endotoxemia. Endotoxin presence was linked to recent high-risk exposure and associated with elevated cytokine levels and decreased CD4+/CD8+ T cell ratios. Taken together, these data show elevated levels of inflammation linked to periods of endotoxemia resulting in a significantly different immune phenotype in a subset of MSM at a high risk of HIV-1 acquisition.
authors.forename: Christine D
authors.initials: CD
authors.lastname: Palmer
authors.forename: Julia
authors.initials: J
authors.lastname: Tomassilli
authors.forename: Michael
authors.initials: M
authors.lastname: Sirignano
authors.forename: Marisol
authors.initials: M
authors.lastname: Romero-Tejeda
authors.forename: Kelly B
authors.initials: KB
authors.lastname: Arnold
authors.forename: Denise
authors.initials: D
authors.lastname: Che
authors.forename: Douglas A
authors.initials: DA
authors.lastname: Lauffenburger
authors.forename: Stephanie
authors.initials: S
authors.lastname: Jost
authors.forename: Todd
authors.initials: T
authors.lastname: Allen
authors.forename: Kenneth H
authors.initials: KH
authors.lastname: Mayer
authors.forename: Marcus
authors.initials: M
authors.lastname: Altfeld
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018959:CD57 Antigens / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D019446:Endotoxemia / Q000276:immunology; D018023:HIV Seronegativity / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology; D018451:Homosexuality, Male / Q000706:statistics & numerical data*; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D008297:Male; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
chemical_list: D018959:CD57 Antigens