title: The C-H activation/1,3-diyne strategy: highly selective direct synthesis of diverse bisheterocycles by Rh(III) catalysis.
abstract: The reactivity and selectivity of 1,3-diynes in transition-metal-catalyzed CH activation is exploited to quickly assemble diverse polysubstituted bisheterocycles, which are highly important but difficult to access. By using the CH activation/1,3-diyne strategy, we overcame the challenges of selectivity (chemo-, regio-, and mono-/diannulation) and constructed seven kinds of adjacent bisheterocycles through the formation of four strategic bonds with high efficiency and high selectivity.
authors.affiliation: Westfälische Wilhelms-Universität Münster, Organisch-Chemisches Institut, Corrensstrasse 40, 48149 Münster (Germany) http://www.uni-muenster.de/Chemie.oc/glorius/
authors.forename: Da-Gang
authors.initials: DG
authors.lastname: Yu
authors.forename: Francisco
authors.initials: F
authors.lastname: de Azambuja
authors.forename: Tobias
authors.initials: T
authors.lastname: Gensch
authors.forename: Constantin G
authors.initials: CG
authors.lastname: Daniliuc
authors.forename: Frank
authors.initials: F
authors.lastname: Glorius
mesh_terms: D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis*; D002384:Catalysis; D007546:Isoquinolines / Q000138:chemical synthesis / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D007546:Isoquinolines; D011725:Pyridines; D012238:Rhodium
keywords: CH activation; RhIII catalysis; alkynes; heterocycles; selectivity