title: Antimicrobial properties of CuO nanorods and multi-armed nanoparticles against B. anthracis vegetative cells and endospores.
abstract: Two different kinds of CuO nanoparticles (NPs) namely CuO nanorods (PS2) and multi-armed nanoparticles (P5) were synthesized by wet and electrochemical routes, respectively. Their structure, morphology, size and compositions were characterized by SEM, EDX and XRD. The NPs demonstrated strong bactericidal potential against Bacillus anthracis cells and endospores. PS2 killed 92.17% of 4.5 × 10(4) CFU/mL B. anthracis cells within 1 h at a dose of 1 mg/mL. Whereas P5 showed a higher efficacy by killing 99.92% of 7 × 10(5) CFU/mL B. anthracis cells within 30 min at a dose of 0.5 mg/mL and 99.6% of 1.25 × 10(4) CFU/mL B. anthracis cells within 5 min at a dose of 2 mg/mL. More than 99% of spores were killed within 8 h with 2 mg/mL PS2 in LB media.
authors.affiliation: Electron Microscopy Division Defence R&D Establishment, New Campus, Jhansi Road, Gwalior, India.
authors.forename: Pratibha
authors.initials: P
authors.lastname: Pandey
authors.affiliation: Microbiology Division Defence R&D Establishment, New Campus, Jhansi Road, Gwalior, India.
authors.forename: Merwyn S
authors.initials: MS
authors.lastname: Packiyaraj
authors.affiliation: Microbiology Division Defence R&D Establishment, New Campus, Jhansi Road, Gwalior, India.
authors.forename: Himangini
authors.initials: H
authors.lastname: Nigam
authors.affiliation: Microbiology Division Defence R&D Establishment, New Campus, Jhansi Road, Gwalior, India.
authors.forename: Gauri S
authors.initials: GS
authors.lastname: Agarwal
authors.affiliation: Electron Microscopy Division Defence R&D Establishment, New Campus, Jhansi Road, Gwalior, India ; Protective Devices Division Defence R&D Establishment, New Campus, Jhansi Road, Gwalior, India.
authors.forename: Beer
authors.initials: B
authors.lastname: Singh
authors.affiliation: Defence Laboratory, Jodhpur, India.
authors.forename: Manoj K
authors.initials: MK
authors.lastname: Patra
keywords: Bacillus anthracis; bactericidal nanoparticles; copper oxide; nanoparticles; spore inactivation