title: The domain landscape of virus-host interactomes.
abstract: Viral infections result in millions of deaths in the world today. A thorough analysis of virus-host interactomes may reveal insights into viral infection and pathogenic strategies. In this study, we presented a landscape of virus-host interactomes based on protein domain interaction. Compared to the analysis at protein level, this domain-domain interactome provided a unique abstraction of protein-protein interactome. Through comparisons among DNA, RNA, and retrotranscribing viruses, we identified a core of human domains, that viruses used to hijack the cellular machinery and evade the immune system, which might be promising antiviral drug targets. We showed that viruses preferentially interacted with host hub and bottleneck domains, and the degree and betweenness centrality among three categories of viruses are significantly different. Further analysis at functional level highlighted that different viruses perturbed the host cellular molecular network by common and unique strategies. Most importantly, we creatively proposed a viral disease network among viral domains, human domains and the corresponding diseases, which uncovered several unknown virus-disease relationships that needed further verification. Overall, it is expected that the findings will help to deeply understand the viral infection and contribute to the development of antiviral therapy.
authors.affiliation: Institute Pasteur of Shanghai, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China ; Hubei Bioinformatics and Molecular Imaging Key Laboratory, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan 430074, China ; Shanghai Center for Bioinformation Technology, 1278 Keyuan Road, Shanghai 201203, China.
authors.forename: Lu-Lu
authors.identifier: 0000-0002-2865-3199
authors.initials: LL
authors.lastname: Zheng
authors.affiliation: Institute Pasteur of Shanghai, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China.
authors.forename: Chunyan
authors.identifier: 0000-0002-4737-6860
authors.initials: C
authors.lastname: Li
authors.affiliation: Institute Pasteur of Shanghai, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China.
authors.forename: Jie
authors.identifier: 0000-0001-9907-5819
authors.initials: J
authors.lastname: Ping
authors.affiliation: Hubei Bioinformatics and Molecular Imaging Key Laboratory, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan 430074, China.
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Shanghai Center for Bioinformation Technology, 1278 Keyuan Road, Shanghai 201203, China ; Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China.
authors.forename: Yixue
authors.initials: Y
authors.lastname: Li
authors.affiliation: Institute Pasteur of Shanghai, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China ; Shanghai Center for Bioinformation Technology, 1278 Keyuan Road, Shanghai 201203, China.
authors.forename: Pei
authors.identifier: 0000-0002-1498-7059
authors.initials: P
authors.lastname: Hao
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry; D015894:Genome, Human; D016679:Genome, Viral; D054884:Host-Pathogen Interactions / Q000235:genetics*; D006801:Humans; D054730:Protein Interaction Domains and Motifs / Q000235:genetics*; D014764:Viral Proteins / Q000737:chemistry* / Q000235:genetics; D014777:Virus Diseases / Q000235:genetics / Q000473:pathology; D014780:Viruses / Q000235:genetics*
chemical_list: D000998:Antiviral Agents; D014764:Viral Proteins