title: Assay of alterations in oxidative stress markers in pigs naturally infested with Sarcoptes scabiei var. suis.
abstract: The present study aimed to examine the status of antioxidant systems of the pigs naturally suffering from sarcoptic mange. Fifty nine pigs were divided into three groups, healthy control (group I, n=15), subclinical sarcoptic mange (group II, n=22) and clinical sarcoptic mange (group III, n=22). To assess the status of antioxidant systems; lipid peroxides (LPO), reduced glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx), ascorbic acid, zinc and copper concentrations in the blood samples as well as LPO, SOD, CAT and glutathione-s-transferase (GST) activities in the skin were measured. The GSH, SOD, GPx, ascorbic acid, zinc, copper concentrations in blood were significantly lower in the pigs suffering from clinical and subclinical sarcoptic mange, when compared with the healthy control. However, LPO content of these infested pigs was significantly higher. The CAT, SOD and GST activities in the skin of the diseased pigs were significantly lower, whereas LPO was significantly higher as compared to the healthy control. From the present study, it may be concluded that sarcoptic mange bestows remarkable alterations in the oxidative stress markers and imposes compromisation of the antioxidant status of the infested pigs.
authors.affiliation: Indian Veterinary Research Institute, Izatnagar-243 122, Uttar Pradesh, India. Electronic address: udimrimesh@rediffmail.com.
authors.forename: Umesh
authors.initials: U
authors.lastname: Dimri
authors.affiliation: Indian Veterinary Research Institute, Izatnagar-243 122, Uttar Pradesh, India.
authors.forename: S
authors.initials: S
authors.lastname: Bandyopadhyay
authors.affiliation: Indian Veterinary Research Institute, Izatnagar-243 122, Uttar Pradesh, India.
authors.forename: Shanker Kumar
authors.initials: SK
authors.lastname: Singh
authors.affiliation: Indian Veterinary Research Institute, Izatnagar-243 122, Uttar Pradesh, India.
authors.forename: Rakesh
authors.initials: R
authors.lastname: Ranjan
authors.affiliation: Indian Veterinary Research Institute, Izatnagar-243 122, Uttar Pradesh, India.
authors.forename: R
authors.initials: R
authors.lastname: Mukherjee
authors.affiliation: Indian Veterinary Research Institute, Izatnagar-243 122, Uttar Pradesh, India.
authors.forename: M I
authors.initials: MI
authors.lastname: Yatoo
authors.affiliation: Indian Veterinary Research Institute, Izatnagar-243 122, Uttar Pradesh, India.
authors.forename: P H
authors.initials: PH
authors.lastname: Patra
authors.affiliation: Indian Veterinary Research Institute, Izatnagar-243 122, Uttar Pradesh, India.
authors.forename: U K
authors.initials: UK
authors.lastname: De
authors.affiliation: Indian Veterinary Research Institute, Izatnagar-243 122, Uttar Pradesh, India.
authors.forename: A A
authors.initials: AA
authors.lastname: Dar
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001205:Ascorbic Acid / Q000097:blood; D015415:Biomarkers / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D003300:Copper / Q000097:blood; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D018384:Oxidative Stress; D012520:Sarcoptes scabiei / Q000502:physiology*; D012532:Scabies / Q000378:metabolism / Q000503:physiopathology*; D013482:Superoxide Dismutase / Q000378:metabolism; D013552:Swine; D015032:Zinc / Q000097:blood
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D003300:Copper; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione; D015032:Zinc; D001205:Ascorbic Acid
keywords: Mange; Oxidative-stress; Pigs; Sarcoptic