title: Diagnostic and prognostic value of presepsin in preterm deliveries.
abstract: OBJECTIVE
  To evaluate the association between serum presepsin (soluble CD14 antigen subtype, sCD14-ST) levels soon after the appearance of signs of preterm delivery and preterm delivery within 48 h, before the 34th and 37th gestational weeks and the possible additional value of concurrently evaluated ultrasound vaginal cervicometry with serum presepsin measurement.
  
  
  METHODS
  A total of 60 females were included. Serum presepsin was measured by a chemiluminescent immunoassay. Sonographic evaluation of cervical length in all females was conducted by transvaginal ultrasound.
  
  
  RESULTS
  Patients who delivered within 48 h after analysis showed significantly higher presepsin concentrations compared to females with later deliveries. Higher presepsin was proven also for deliveries before/after weeks 34 and 37. A combined finding of cervical length shortening below 18 mm and presepsin level increasing above 623.5 pg/mL could point to the significantly high risk of preterm delivery.
  
  
  CONCLUSIONS
  Elevated maternal serum concentration of sCD14-ST could be an independent and relevant risk factor for preterm delivery.
authors.affiliation: Institute of Medical Biochemistry and Laboratory Diagnostics and.
authors.forename: Karin
authors.initials: K
authors.lastname: Malíčková
authors.forename: Michal
authors.initials: M
authors.lastname: Koucký
authors.forename: Antonín
authors.initials: A
authors.lastname: Pařízek
authors.forename: Květa
authors.initials: K
authors.lastname: Pelinková
authors.forename: Helena
authors.initials: H
authors.lastname: Brodská
authors.forename: Zdeněk
authors.initials: Z
authors.lastname: Hájek
authors.forename: Anna
authors.initials: A
authors.lastname: Germanová
authors.forename: Oto
authors.initials: O
authors.lastname: Mestek
authors.forename: Tomáš
authors.initials: T
authors.lastname: Zima
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D054791:Cervical Length Measurement; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D039841:Leukocyte L1 Antigen Complex / Q000097:blood; D018950:Lipopolysaccharide Receptors / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011247:Pregnancy; D011256:Pregnancy Outcome; D047928:Premature Birth / Q000097:blood* / Q000000981:diagnostic imaging; D011379:Prognosis
chemical_list: D015415:Biomarkers; C508600:IL6 protein, human; D015850:Interleukin-6; D039841:Leukocyte L1 Antigen Complex; D018950:Lipopolysaccharide Receptors; D010446:Peptide Fragments; C000594167:presepsin protein, human; D002097:C-Reactive Protein
keywords: Cervical length; inflammation; inflammatory biomarkers; sCD14-ST