title: Interplay between intra- and interhemispheric remodeling of neural networks as a substrate of functional recovery after stroke: adaptive versus maladaptive reorganization.
abstract: Brain injuries such as focal stroke initiate a myriad of neural events leading to local and remote alterations in cerebral networks. The neurochemical and neurophysiological mechanisms underlying these postlesion changes raise the question of their beneficial or adverse effects on functional recovery. In this review, we aim to reconcile findings from animal and patients studies using a "from cellular-to network-levels" perspective to gain further insights into the neuroplasticity mechanisms underlying recovery of sensorimotor functions. Ultimately, an integrative view of the multiple facets of poststroke changes should give an impetus to novel neurorehabilitation strategies by providing evidence of how neuroscience findings can be translated and operationalized within the context of restorative stroke.
authors.affiliation: Aix-Marseille Université, CNRS, Neurosciences Intégratives et Adaptatives - UMR 7260, Fédération de Recherches CNRS 3C 3512, Pole 3C, Case B, 3 Place Victor Hugo, 13331 Marseille cedex 03, France. Electronic address: christian.xerri@univ-amu.fr.
authors.forename: C
authors.initials: C
authors.lastname: Xerri
authors.affiliation: Aix-Marseille Université, CNRS, Neurosciences Intégratives et Adaptatives - UMR 7260, Fédération de Recherches CNRS 3C 3512, Pole 3C, Case B, 3 Place Victor Hugo, 13331 Marseille cedex 03, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Zennou-Azogui
authors.affiliation: Aix-Marseille Université, CNRS, Neurosciences Intégratives et Adaptatives - UMR 7260, Fédération de Recherches CNRS 3C 3512, Pole 3C, Case B, 3 Place Victor Hugo, 13331 Marseille cedex 03, France.
authors.forename: K
authors.initials: K
authors.lastname: Sadlaoud
authors.affiliation: Aix-Marseille Université, CNRS, Neurosciences Intégratives et Adaptatives - UMR 7260, Fédération de Recherches CNRS 3C 3512, Pole 3C, Case B, 3 Place Victor Hugo, 13331 Marseille cedex 03, France.
authors.forename: D
authors.initials: D
authors.lastname: Sauvajon
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D001931:Brain Mapping; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology*; D020127:Recovery of Function / Q000502:physiology*; D012149:Restraint, Physical / Q000379:methods; D020521:Stroke / Q000503:physiopathology*; D000071939:Stroke Rehabilitation
keywords: constraint-induced movement therapy; cortical remapping; focal stroke; interhemispheric inhibition; ipsi/contralesional hemisphere