title: microRNA‑802 promotes lung carcinoma proliferation by targeting the tumor suppressor menin.
abstract: microRNAs play important roles in numerous biological processes, including tumorigenesis, by modulating critical gene transcripts. In the present study, the role of microRNA‑802 (miR‑802) in lung cancer was investigated. The results of the quantitative polymerase chain reaction revealed that expression levels of miR‑802 were significantly upregulated in lung cancer tissues. In vitro experiments demonstrated that miR‑802 promoted cell proliferation in A549, NCI‑H358 and NCI‑H1299 cells. Furthermore, it was indicated that miR‑802 promoted the proliferation of lung carcinoma by targeting the tumor suppressor menin. Therefore, these results suggest a previously unknown miR‑802/menin molecular network controlling lung carcinoma development.
authors.affiliation: Department of Thoracic Surgery, Provincial Hospital Afﬁliated to Shandong University, Jinan, Shandong 250021, P.R. China.
authors.forename: Lun-Qing
authors.initials: LQ
authors.lastname: Wang
authors.affiliation: Department of Thoracic Surgery, Provincial Hospital Afﬁliated to Shandong University, Jinan, Shandong 250021, P.R. China.
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.affiliation: Department of Thoracic Surgery, Provincial Hospital Afﬁliated to Shandong University, Jinan, Shandong 250021, P.R. China.
authors.forename: Xiang-Yan
authors.initials: XY
authors.lastname: Liu
authors.affiliation: Department of Thoracic Surgery, Provincial Hospital Afﬁliated to Shandong University, Jinan, Shandong 250021, P.R. China.
authors.forename: Fan-Ying
authors.initials: FY
authors.lastname: Liu
authors.affiliation: Department of Cardiology, The Affiliated Cardiovascular Hospital of Medical College, Qingdao University, Jinan, Shandong 266071, P.R. China.
authors.forename: Shao-Yan
authors.initials: SY
authors.lastname: Jiang
authors.affiliation: Department of Thoracic Surgery, Provincial Hospital Afﬁliated to Shandong University, Jinan, Shandong 250021, P.R. China.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Wang
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D016133:Polymerase Chain Reaction; D011401:Promoter Regions, Genetic; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D015854:Up-Regulation
chemical_list: C105373:MEN1 protein, human; C552280:MIRN802 microRNA, human; D035683:MicroRNAs; D011518:Proto-Oncogene Proteins