title: Laryngeal cancer in Finland: A 5-year follow-up study of 366 patients.
abstract: BACKGROUND
  The purpose of this study was to acquire nationwide data on the management and outcome of laryngeal squamous cell carcinoma (SCC) in Finnish university hospitals over a 5-year posttreatment follow-up.
  
  
  METHODS
  All records of patients diagnosed and treated for primary laryngeal SCC during 2001 to 2005 were reviewed.
  
  
  RESULTS
  Three hundred sixty-six patients with laryngeal cancer were identified, 360 of whom had laryngeal SCC. Three hundred forty-two patients with laryngeal SCC (95%) were treated with curative intent. Five-year disease-specific survival (DSS) for T1a, T1b, T2, T3, and T4 glottic SCC was 100%, 95%, 78%, 79%, and 53%, respectively. The corresponding figures for T1 to T4 supraglottic SCC were 68%, 54%, 72%, and 59%.
  
  
  CONCLUSIONS
  Results of this nationwide study give a general overview of the outcome of unselected patients treated with unified guidelines. Patients with T2 tumors, usually treated with radiotherapy (RT), had a worse prognosis than expected. This patient group warrants further investigation and possibly treatment intensification.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.
authors.forename: Aaro
authors.initials: A
authors.lastname: Haapaniemi
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Oulu University Hospital and University of Oulu, Oulu, Finland.
authors.forename: Petri
authors.initials: P
authors.lastname: Koivunen
authors.affiliation: Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland.
authors.forename: Kauko
authors.initials: K
authors.lastname: Saarilahti
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Turku University Hospital and University of Turku, Turku, Finlan.
authors.forename: Ilpo
authors.initials: I
authors.lastname: Kinnunen
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Tampere University Hospital and University of Tampere, Tampere, Finland.
authors.forename: Jussi
authors.initials: J
authors.lastname: Laranne
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.
authors.forename: Leena-Maija
authors.initials: LM
authors.lastname: Aaltonen
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Kuopio University Hospital and University of Kuopio, Kuopio, Finland.
authors.forename: Mervi
authors.initials: M
authors.lastname: Närkiö
authors.affiliation: Department of Oncology, Turku University Hospital and University of Turku, Turku, Finland.
authors.forename: Paula
authors.initials: P
authors.lastname: Lindholm
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Turku University Hospital and University of Turku, Turku, Finlan.
authors.forename: Reidar
authors.initials: R
authors.lastname: Grénman
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.
authors.forename: Antti
authors.initials: A
authors.lastname: Mäkitie
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.
authors.forename: Timo
authors.initials: T
authors.lastname: Atula
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D018572:Disease-Free Survival; D005260:Female; D005387:Finland; D005500:Follow-Up Studies; D006785:Hospitals, University; D006801:Humans; D053208:Kaplan-Meier Estimate; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: carcinoma; chemoradiotherapy; larynx; recurrence; treatment outcome