title: Mean platelet volume is associated with myocardial perfusion defect in diabetic patients.
abstract: OBJECTIVE
  Our aim was to evaluate whether there was a relationship between mean platelet volume and myocardial perfusion defect in diabetic patients using myocardial perfusion imaging.
  
  
  METHODS
  Forty-four diabetic patients with myocardial perfusion defect (group 1) and 44 diabetic patients without myocardial perfusion defect (group 2), matched for age and gender, were retrospectively examined. Levels of mean platelet volume (MPV) in the two groups were assessed.
  
  
  RESULTS
  MPV was higher in group 1 than group 2 patients (8.76 ± 0.76 and 8.25 ± 0.78 fl), respectively, p = 0.003). Levels of glucose, triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, haemoglobin (Hb) and glycosylated haemoglobin (HbA1c), and body mass index (BMI) in the two groups were not statistically significantly different. Multivariate logistic regression analyses showed that MPV was the only variable independently associated with myocardial perfusion defects (OR: 2.401, 95% CI: 1.298-4.440, p = 0.013).
  
  
  CONCLUSIONS
  This study showed that higher MPV was associated with myocardial perfusion defects. Higher MPV in diabetic patients was independently related to myocardial perfusion defects and may be an indicator of myocardial ischaemia.
authors.affiliation: Department of Cardiology, School of Medicine, Bozok University, Yozgat, Turkey.
authors.forename: Savas
authors.initials: S
authors.lastname: Sarikaya
authors.affiliation: Department of Internal Medicine, School of Medicine, Gaziosmanpasa University, Tokat, Turkey. drsafaksahin@gmail.com.
authors.forename: Safak
authors.initials: S
authors.lastname: Sahin
authors.affiliation: Department of Internal Medicine, School of Medicine, Bozok University, Yozgat, Turkey.
authors.forename: Lutfi
authors.initials: L
authors.lastname: Akyol
authors.affiliation: Department of Internal Medicine, School of Medicine, Bozok University, Yozgat, Turkey.
authors.forename: Elif
authors.initials: E
authors.lastname: Borekci
authors.affiliation: Department of Cardiovascular Surgery, School of Medicine, Bozok University, Yozgat, Turkey.
authors.forename: Yunus Keser
authors.initials: YK
authors.lastname: Yilmaz
authors.affiliation: Department of Cardiology, School of Medicine, Gaziosmanpasa University, Tokat, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Altunkas
authors.affiliation: Department of Cardiology, School of Medicine, Gaziosmanpasa University, Tokat, Turkey.
authors.forename: Kayihan
authors.initials: K
authors.lastname: Karaman
authors.affiliation: Department of Nuclear Medicine, School of Medicine, Bozok University, Yozgat, Turkey.
authors.forename: Seyhan
authors.initials: S
authors.lastname: Karacavus
authors.affiliation: Department of Cardiology, School of Medicine, Bozok University, Yozgat, Turkey.
authors.forename: Ali Riza
authors.initials: AR
authors.lastname: Erbay
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism; D001792:Blood Platelets / Q000473:pathology*; D008076:Cholesterol, HDL / Q000378:metabolism; D003324:Coronary Artery Disease / Q000150:complications / Q000175:diagnosis*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL