title: Glycan receptors of the Polyomaviridae: structure, function, and pathogenesis.
abstract: Multiple glycans have been identified as potential cell surface binding motifs for polyomaviruses (PyVs) using both crystallographic structural determinations and in vitro binding assays. However, binding alone does not necessarily imply that a glycan is a functional receptor, and confirmation that specific glycans are important for infection has proved challenging. In vivo analysis of murine polyomavirus (MPyV) infection has shown that subtle alterations in PyV-glycan interactions alone can result in dramatic changes in pathogenicity, implying that similar effects will be found for other PyVs. Our discussion will review the assays used for determining virus-glycan binding, and how these relate to known PyV tropism and pathogenesis.
authors.affiliation: Department of Molecular, Cellular, Developmental Biology, University of Colorado-Boulder, 347 UCB, Boulder, CO 80309, United States; BioFrontiers Institute, University of Colorado-Boulder, 596 UCB, Boulder, CO 80309, United States.
authors.forename: Samantha D
authors.initials: SD
authors.lastname: O'Hara
authors.affiliation: Interfaculty Institute of Biochemistry, University of Tuebingen, Tuebingen, Germany; Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, United States.
authors.forename: Thilo
authors.initials: T
authors.lastname: Stehle
authors.affiliation: Department of Molecular, Cellular, Developmental Biology, University of Colorado-Boulder, 347 UCB, Boulder, CO 80309, United States; BioFrontiers Institute, University of Colorado-Boulder, 596 UCB, Boulder, CO 80309, United States. Electronic address: robert.garcea@colorado.edu.
authors.forename: Robert
authors.initials: R
authors.lastname: Garcea
mesh_terms: D000818:Animals; D006801:Humans; D027382:Polyomaviridae / Q000235:genetics / Q000378:metabolism*; D027601:Polyomavirus Infections / Q000378:metabolism* / Q000821:virology; D011134:Polysaccharides / Q000378:metabolism*; D011991:Receptors, Virus / Q000378:metabolism*; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D011134:Polysaccharides; D011991:Receptors, Virus; D014764:Viral Proteins