title: Mixed micelle cloud point-magnetic dispersive μ-solid phase extraction of doxazosin and alfuzosin.
abstract: Mixed micelle cloud point extraction (MM-CPE) combined with magnetic dispersive μ-solid phase extraction (MD-μ-SPE) has been developed as a new approach for the extraction of doxazosin (DOX) and alfuzosin (ALF) prior to fluorescence analysis. The mixed micelle anionic surfactant sodium dodecyl sulfate and non-ionic polyoxyethylene(7.5)nonylphenylether was used as the extraction solvent in MM-CPE, and diatomite bonding Fe₃O₄ magnetic nanoparticles were used as the adsorbent in MD-μ-SPE. The method was based on MM-CPE of DOX and ALF in the surfactant-rich phase. Magnetic materials were used to retrieve the surfactant-rich phase, which easily separated from the aqueous phase under magnetic field. At optimum conditions, a linear relationship between DOX and ALF was obtained in the range of 5-300 ng mL(-1), and the limits of detection were 0.21 and 0.16 ng mL(-1), respectively. The proposed method was successfully applied for the determination of the drugs in pharmaceutical preparations, urine samples, and plasma samples.
authors.affiliation: Analytical and Testing Center, Shanxi Normal University, Linfen, Shanxi 041004, PR China.
authors.forename: Nannan
authors.initials: N
authors.lastname: Gao
authors.affiliation: Analytical and Testing Center, Shanxi Normal University, Linfen, Shanxi 041004, PR China. Electronic address: fxcszx@163.com.
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
authors.affiliation: Analytical and Testing Center, Shanxi Normal University, Linfen, Shanxi 041004, PR China.
authors.forename: Yafen
authors.initials: Y
authors.lastname: Chang
authors.affiliation: Analytical and Testing Center, Shanxi Normal University, Linfen, Shanxi 041004, PR China.
authors.forename: Xiaozhen
authors.initials: X
authors.lastname: Guo
authors.affiliation: Analytical and Testing Center, Shanxi Normal University, Linfen, Shanxi 041004, PR China.
authors.forename: Lizhen
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Analytical and Testing Center, Shanxi Normal University, Linfen, Shanxi 041004, PR China. Electronic address: lmd@dns.sxnu.edu.cn.
authors.forename: Liming
authors.initials: L
authors.lastname: Du
authors.affiliation: Analytical and Testing Center, Shanxi Normal University, Linfen, Shanxi 041004, PR China.
authors.forename: Yunlong
authors.initials: Y
authors.lastname: Fu
mesh_terms: D002138:Calibration; D017292:Doxazosin / Q000032:analysis* / Q000097:blood / Q000302:isolation & purification*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057230:Limit of Detection; D060328:Magnetic Phenomena; D058185:Magnetite Nanoparticles; D008823:Micelles; D011799:Quinazolines / Q000032:analysis* / Q000097:blood / Q000302:isolation & purification*; D012965:Sodium Chloride / Q000737:chemistry; D012967:Sodium Dodecyl Sulfate; D052616:Solid Phase Extraction / Q000295:instrumentation / Q000379:methods*; D012997:Solvents / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D013501:Surface-Active Agents / Q000737:chemistry; D013696:Temperature
chemical_list: D058185:Magnetite Nanoparticles; D008823:Micelles; D011799:Quinazolines; D012997:Solvents; D013501:Surface-Active Agents; D012967:Sodium Dodecyl Sulfate; D012965:Sodium Chloride; C047638:alfuzosin; D017292:Doxazosin
keywords: Alfuzosin; Doxazosin; Fluorescence; Magnetic dispersive μ-solid phase extraction; Mixed micelle cloud point extraction