title: The effect of some 4,2 and 5,2 bisthiazole derivatives on nitro-oxidative stress and phagocytosis in acute experimental inflammation.
abstract: Nineteen bisthiazoles were tested in order to assess their anti-inflammatory and antioxidant properties. First, we evaluated the in vitro direct antioxidant capacity of the bisthiazoles using the DPPH radical scavenging method. Then, the anti-inflammatory effect was tested in acute rat experimental inflammation by measuring the acute phase bone marrow response, the phagocytic capacity and the serum nitro-oxidative stress status. Although none of the substances showed significant direct antioxidant potential in the DPPH assay, most of them improved serum oxidative status, when administered to rats with inflammation. Four of the bisthiazoles proved to have good anti-inflammatory properties, similar or superior to that of equal doses meloxicam.
authors.affiliation: Department of Therapeutic Chemistry, Faculty of Pharmacy, "Iuliu Haţieganu" University of Medicine and Pharmacy, 12 Ion Creanga Street, 400010 Cluj-Napoca, Romania. araniciu.catalin@umfcluj.ro.
authors.forename: Cătălin
authors.initials: C
authors.lastname: Araniciu
authors.affiliation: Department of Physiopathology, Faculty of Medicine, "Iuliu Haţieganu" University of Medicine and Pharmacy, 2-4 Victor Babes Street, 400010 Cluj-Napoca, Romania. parvualinaelena@umfcluj.ro.
authors.forename: Alina Elena
authors.initials: AE
authors.lastname: Pârvu
authors.affiliation: Department of Therapeutic Chemistry, Faculty of Pharmacy, "Iuliu Haţieganu" University of Medicine and Pharmacy, 12 Ion Creanga Street, 400010 Cluj-Napoca, Romania. mpalage@umfcluj.ro.
authors.forename: Mariana Doina
authors.initials: MD
authors.lastname: Palage
authors.affiliation: Department of Therapeutic Chemistry, Faculty of Pharmacy, "Iuliu Haţieganu" University of Medicine and Pharmacy, 12 Ion Creanga Street, 400010 Cluj-Napoca, Romania. smaranda.oniga@umfcluj.ro.
authors.forename: Smaranda Dafina
authors.initials: SD
authors.lastname: Oniga
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, "Iuliu Haţieganu" University of Medicine and Pharmacy, 12 I. Creanga Street, 400010 Cluj-Napoca, Romania. dbenedec@umfcluj.ro.
authors.forename: Daniela
authors.initials: D
authors.lastname: Benedec
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, "Iuliu Haţieganu" University of Medicine and Pharmacy, 12 I. Creanga Street, 400010 Cluj-Napoca, Romania. ioniga@umfcluj.ro.
authors.forename: Ilioara
authors.initials: I
authors.lastname: Oniga
authors.affiliation: Department of Therapeutic Chemistry, Faculty of Pharmacy, "Iuliu Haţieganu" University of Medicine and Pharmacy, 12 Ion Creanga Street, 400010 Cluj-Napoca, Romania. ooniga@umfcluj.ro.
authors.forename: Ovidiu
authors.initials: O
authors.lastname: Oniga
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D016166:Free Radical Scavengers / Q000737:chemistry; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D000077239:Meloxicam; D018384:Oxidative Stress; D010587:Phagocytosis / Q000187:drug effects*; D017208:Rats, Wistar; D026361:Reactive Nitrogen Species / Q000097:blood* / Q000502:physiology; D013843:Thiazines / Q000494:pharmacology; D013844:Thiazoles / Q000737:chemistry / Q000494:pharmacology*; D014425:Turpentine
chemical_list: D000893:Anti-Inflammatory Agents; D016166:Free Radical Scavengers; D026361:Reactive Nitrogen Species; D013843:Thiazines; D013844:Thiazoles; D000077239:Meloxicam; D014425:Turpentine