title: Pittsburgh outcomes after stroke thrombectomy score predicts outcomes after endovascular therapy for anterior circulation large vessel occlusions.
abstract: OBJECTIVE
  Prognostication tools that predict good outcome in patients with anterior circulation large vessel occlusions after endovascular therapy are lacking. We aim to develop a tool that incorporates clinical and imaging data to predict outcomes after endovascular therapy.
  
  
  METHODS
  In a derivation cohort of anterior circulation large vessel occlusion stroke patients treated with endovascular therapy within 8 hours from time last seen well (n=247), we performed logistic regression to identify independent predictors of good outcome (90-day modified Rankin Scale, 0-2). Factors were weighted based on β-coefficients to derive the Pittsburgh Outcomes After Stroke Thrombectomy (POST) score. POST was validated in an institutional endovascular database (University of Pittsburgh Medical Center, n=393) and the Diffusion-Weighted Imaging Evaluation for Understanding Stroke Evolution Study-2 (DEFUSE-2) data set (n=105), as well as in patients treated beyond 8 hours (n=194) and in octogenarians (n=111).
  
  
  RESULTS
  In the derivation cohort, independent predictors (P<0.1) of good outcome included 24- to 72-hour final infarct volume (in cm(3), P<0.001), age (years, P<0.001), and parenchymal hematoma types 1 and 2 (H, P=0.01). POST was calculated as age+0.5×final infarct volume+15×H. Patients with POST score <60 had a 91% chance of good outcome compared with 4% with POST score ≥120. POST accurately predicted good outcomes in the derivation (area under the curve [AUC]=0.85) and validation cohorts (University of Pittsburgh Medical Center, AUC=0.81; DEFUSE-2, AUC=0.86), as well as in patients treated beyond 8 hours (AUC, 0.85) and octogenarians (AUC=0.76). POST had better predictive accuracy for good and poor outcome than the ischemic stroke predictive risk score (iSCORE).
  
  
  CONCLUSIONS
  POST score is a validated predictor of outcome in patients with anterior circulation large vessel occlusions after endovascular therapy.
authors.affiliation: From the Department of Neurology, University of Pittsburgh Medical Center, PA (S.R., A.A., C.S., A.J., T.G.J.); Marcus Stroke and Neuroscience Center, Grady Memorial Hospital, Atlanta, GA (C.-H.S., R.N., M.F.); Wellstar Neurosurgery, Atlanta, GA (R.G.); and Stanford Stroke Center, Stanford University Medical Center, CA (J.T.P.L., M.M., M.L., G.A.).
authors.forename: Srikant
authors.initials: S
authors.lastname: Rangaraju
authors.affiliation: From the Department of Neurology, University of Pittsburgh Medical Center, PA (S.R., A.A., C.S., A.J., T.G.J.); Marcus Stroke and Neuroscience Center, Grady Memorial Hospital, Atlanta, GA (C.-H.S., R.N., M.F.); Wellstar Neurosurgery, Atlanta, GA (R.G.); and Stanford Stroke Center, Stanford University Medical Center, CA (J.T.P.L., M.M., M.L., G.A.).
authors.forename: John T P
authors.initials: JT
authors.lastname: Liggins
authors.affiliation: From the Department of Neurology, University of Pittsburgh Medical Center, PA (S.R., A.A., C.S., A.J., T.G.J.); Marcus Stroke and Neuroscience Center, Grady Memorial Hospital, Atlanta, GA (C.-H.S., R.N., M.F.); Wellstar Neurosurgery, Atlanta, GA (R.G.); and Stanford Stroke Center, Stanford University Medical Center, CA (J.T.P.L., M.M., M.L., G.A.).
authors.forename: Amin
authors.initials: A
authors.lastname: Aghaebrahim
authors.affiliation: From the Department of Neurology, University of Pittsburgh Medical Center, PA (S.R., A.A., C.S., A.J., T.G.J.); Marcus Stroke and Neuroscience Center, Grady Memorial Hospital, Atlanta, GA (C.-H.S., R.N., M.F.); Wellstar Neurosurgery, Atlanta, GA (R.G.); and Stanford Stroke Center, Stanford University Medical Center, CA (J.T.P.L., M.M., M.L., G.A.).
authors.forename: Christopher
authors.initials: C
authors.lastname: Streib
authors.affiliation: From the Department of Neurology, University of Pittsburgh Medical Center, PA (S.R., A.A., C.S., A.J., T.G.J.); Marcus Stroke and Neuroscience Center, Grady Memorial Hospital, Atlanta, GA (C.-H.S., R.N., M.F.); Wellstar Neurosurgery, Atlanta, GA (R.G.); and Stanford Stroke Center, Stanford University Medical Center, CA (J.T.P.L., M.M., M.L., G.A.).
authors.forename: Chung-Huan
authors.initials: CH
authors.lastname: Sun
authors.affiliation: From the Department of Neurology, University of Pittsburgh Medical Center, PA (S.R., A.A., C.S., A.J., T.G.J.); Marcus Stroke and Neuroscience Center, Grady Memorial Hospital, Atlanta, GA (C.-H.S., R.N., M.F.); Wellstar Neurosurgery, Atlanta, GA (R.G.); and Stanford Stroke Center, Stanford University Medical Center, CA (J.T.P.L., M.M., M.L., G.A.).
authors.forename: Rishi
authors.initials: R
authors.lastname: Gupta
authors.affiliation: From the Department of Neurology, University of Pittsburgh Medical Center, PA (S.R., A.A., C.S., A.J., T.G.J.); Marcus Stroke and Neuroscience Center, Grady Memorial Hospital, Atlanta, GA (C.-H.S., R.N., M.F.); Wellstar Neurosurgery, Atlanta, GA (R.G.); and Stanford Stroke Center, Stanford University Medical Center, CA (J.T.P.L., M.M., M.L., G.A.).
authors.forename: Raul
authors.initials: R
authors.lastname: Nogueira
authors.affiliation: From the Department of Neurology, University of Pittsburgh Medical Center, PA (S.R., A.A., C.S., A.J., T.G.J.); Marcus Stroke and Neuroscience Center, Grady Memorial Hospital, Atlanta, GA (C.-H.S., R.N., M.F.); Wellstar Neurosurgery, Atlanta, GA (R.G.); and Stanford Stroke Center, Stanford University Medical Center, CA (J.T.P.L., M.M., M.L., G.A.).
authors.forename: Michael
authors.initials: M
authors.lastname: Frankel
authors.affiliation: From the Department of Neurology, University of Pittsburgh Medical Center, PA (S.R., A.A., C.S., A.J., T.G.J.); Marcus Stroke and Neuroscience Center, Grady Memorial Hospital, Atlanta, GA (C.-H.S., R.N., M.F.); Wellstar Neurosurgery, Atlanta, GA (R.G.); and Stanford Stroke Center, Stanford University Medical Center, CA (J.T.P.L., M.M., M.L., G.A.).
authors.forename: Michael
authors.initials: M
authors.lastname: Mlynash
authors.affiliation: From the Department of Neurology, University of Pittsburgh Medical Center, PA (S.R., A.A., C.S., A.J., T.G.J.); Marcus Stroke and Neuroscience Center, Grady Memorial Hospital, Atlanta, GA (C.-H.S., R.N., M.F.); Wellstar Neurosurgery, Atlanta, GA (R.G.); and Stanford Stroke Center, Stanford University Medical Center, CA (J.T.P.L., M.M., M.L., G.A.).
authors.forename: Maarten
authors.initials: M
authors.lastname: Lansberg
authors.affiliation: From the Department of Neurology, University of Pittsburgh Medical Center, PA (S.R., A.A., C.S., A.J., T.G.J.); Marcus Stroke and Neuroscience Center, Grady Memorial Hospital, Atlanta, GA (C.-H.S., R.N., M.F.); Wellstar Neurosurgery, Atlanta, GA (R.G.); and Stanford Stroke Center, Stanford University Medical Center, CA (J.T.P.L., M.M., M.L., G.A.).
authors.forename: Gregory
authors.initials: G
authors.lastname: Albers
authors.affiliation: From the Department of Neurology, University of Pittsburgh Medical Center, PA (S.R., A.A., C.S., A.J., T.G.J.); Marcus Stroke and Neuroscience Center, Grady Memorial Hospital, Atlanta, GA (C.-H.S., R.N., M.F.); Wellstar Neurosurgery, Atlanta, GA (R.G.); and Stanford Stroke Center, Stanford University Medical Center, CA (J.T.P.L., M.M., M.L., G.A.).
authors.forename: Ashutosh
authors.initials: A
authors.lastname: Jadhav
authors.affiliation: From the Department of Neurology, University of Pittsburgh Medical Center, PA (S.R., A.A., C.S., A.J., T.G.J.); Marcus Stroke and Neuroscience Center, Grady Memorial Hospital, Atlanta, GA (C.-H.S., R.N., M.F.); Wellstar Neurosurgery, Atlanta, GA (R.G.); and Stanford Stroke Center, Stanford University Medical Center, CA (J.T.P.L., M.M., M.L., G.A.). jovintg@upmc.edu.
authors.forename: Tudor G
authors.initials: TG
authors.lastname: Jovin
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D020521:Stroke / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D017131:Thrombectomy; D015912:Thrombolytic Therapy; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D010959:Tissue Plasminogen Activator
keywords: cerebrovascular occlusion; endovascular procedures; infarction; ischemia; prognosis; stroke; thrombectomy