title: Neutralizing effects of Mimosa tenuiflora extracts against inflammation caused by Tityus serrulatus scorpion venom.
abstract: Scorpion bite represents a significant and serious public health problem in certain regions of Brazil, as well as in other parts of the world. Inflammatory mediators are thought to be involved in the systemic and local immune response induced by Tityus serrulatus scorpion envenomation. The aim of this study was to evaluate the effect of extracts of Mimosa tenuiflora on model envenomation. In mice, the envenomation model is induced by Tityus serrulatus venom. Previous treatment of mice with fractions from M. tenuiflora was able to suppress the cell migration to the peritoneal cavity. The treatment of mice with M. tenuiflora extracts also decreased the levels of IL-6, IL-12, and IL-1β. We concluded that the administration of the extract and fractions resulted in a reduction in cell migration and showed a reduction in the level of proinflammatory cytokines. This study demonstrates, for the first time, the anti-inflammatory effect of aqueous extract from the Mimosa tenuiflora plant on T. serrulatus venom.
authors.affiliation: Laboratory of Pharmaceutical Technology and Biotechnology, Department of Pharmacy, Federal University of Rio Grande do Norte, Avenue General Gustavo Cordeiro de Farias, Petrópolis, 59012-570 Natal, RN, Brazil.
authors.forename: Mariana Angélica Oliveira
authors.initials: MA
authors.lastname: Bitencourt
authors.affiliation: Laboratory of Pharmaceutical Technology and Biotechnology, Department of Pharmacy, Federal University of Rio Grande do Norte, Avenue General Gustavo Cordeiro de Farias, Petrópolis, 59012-570 Natal, RN, Brazil.
authors.forename: Maira Conceição Jerônimo
authors.initials: MC
authors.lastname: de Souza Lima
authors.affiliation: Laboratory of Pharmaceutical Technology and Biotechnology, Department of Pharmacy, Federal University of Rio Grande do Norte, Avenue General Gustavo Cordeiro de Farias, Petrópolis, 59012-570 Natal, RN, Brazil.
authors.forename: Manoela
authors.initials: M
authors.lastname: Torres-Rêgo
authors.affiliation: Laboratory of Pharmacognosy, Department of Pharmacy, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
authors.forename: Júlia Morais
authors.identifier: 0000-0001-9769-5352
authors.initials: JM
authors.lastname: Fernandes
authors.affiliation: Laboratory of Pharmaceutical Technology and Biotechnology, Department of Pharmacy, Federal University of Rio Grande do Norte, Avenue General Gustavo Cordeiro de Farias, Petrópolis, 59012-570 Natal, RN, Brazil.
authors.forename: Arnóbio Antônio
authors.initials: AA
authors.lastname: da Silva-Júnior
authors.affiliation: Laboratory of Immunochemistry, Butantan Institute, São Paulo, SP, Brazil.
authors.forename: Denise Vilarinho
authors.initials: DV
authors.lastname: Tambourgi
authors.affiliation: Laboratory of Pharmacognosy, Department of Pharmacy, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
authors.forename: Silvana Maria
authors.initials: SM
authors.lastname: Zucolotto
authors.affiliation: Laboratory of Pharmaceutical Technology and Biotechnology, Department of Pharmacy, Federal University of Rio Grande do Norte, Avenue General Gustavo Cordeiro de Farias, Petrópolis, 59012-570 Natal, RN, Brazil.
authors.forename: Matheus
authors.identifier: 0000-0003-4221-9580
authors.initials: M
authors.lastname: de Freitas Fernandes-Pedrosa
mesh_terms: D000818:Animals; D001938:Brazil; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D018664:Interleukin-12 / Q000096:biosynthesis; D053583:Interleukin-1beta / Q000096:biosynthesis; D015850:Interleukin-6 / Q000096:biosynthesis; D051379:Mice; D031298:Mimosa / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry; D012604:Scorpion Venoms / Q000633:toxicity*; D012605:Scorpions / Q000472:pathogenicity
chemical_list: D053583:Interleukin-1beta; D015850:Interleukin-6; D010936:Plant Extracts; D012604:Scorpion Venoms; D018664:Interleukin-12