title: Inhibitory effects of (-)-loliolide on cellular senescence in human dermal fibroblasts.
abstract: Cellular senescence influences tumor suppression and progress, tissue repair and regeneration, tissue and organismal aging, and age-related diseases. Aging intervention might be an advantageous target for prevention and treatment of diverse age-related diseases. In this study, we investigated whether (-)-loliolide purified from the crude extract of Polygonum aviculare exerted inhibitory activity against cellular senescence in human dermal fibroblasts (HDFs). (-)-Loliolide diminished senescence-associated β-galactosidase activity (SA-β-gal), the level of p21 protein, and the level of reactive oxygen species in senescent cells induced by adriamycin treatment. (-)-Loliolide also attenuated SA-β-gal activity in HDFs under replicative senescence. These findings imply that (-)-loliolide rescues cellular senescence in HDFs and might be useful for the development of dietary supplements or cosmetics that ameliorate tissue aging or age-associated diseases.
authors.affiliation: Department of Biochemistry and Molecular Biology, College of Medicine, Yeungnam University, 170 Hyunchung-Ro, Daegu, 705-717, Republic of Korea.
authors.forename: Hyo Hyun
authors.initials: HH
authors.lastname: Yang
authors.forename: Kyoung
authors.initials: K
authors.lastname: Hwangbo
authors.forename: Ming Shan
authors.initials: MS
authors.lastname: Zheng
authors.forename: Jung Hee
authors.initials: JH
authors.lastname: Cho
authors.forename: Jong-Keun
authors.initials: JK
authors.lastname: Son
authors.forename: Hwa Young
authors.initials: HY
authors.lastname: Kim
authors.forename: Suk Hwan
authors.initials: SH
authors.lastname: Baek
authors.forename: Hyung Chul
authors.initials: HC
authors.lastname: Choi
authors.forename: So Young
authors.initials: SY
authors.lastname: Park
authors.forename: Jae-Ryong
authors.initials: JR
authors.lastname: Kim
mesh_terms: D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D016922:Cellular Senescence / Q000187:drug effects* / Q000502:physiology; D020405:Dermis / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D028502:Polygonum
chemical_list: D001572:Benzofurans; D010936:Plant Extracts; C030425:loliolide