title: MRI signal-based quantification of subchondral bone at the tibial plateau: a population study.
abstract: OBJECTIVE
  To determine whether differences in subchondral sclerosis at the tibial plateau could be detected with magnetic resonance (MR) imaging in two different age groups.
  
  
  METHODS
  This was a retrospective hypothesis-testing study. Thirty-two knees in group A (25-30 year olds) and 32 knees in group B (45-50 years old) were included. Participants had no MR features of osteoarthritis (OA). On coronal images, tibial articular cartilage thickness was measured, and regions of interest were created in the medial and lateral tibial plateau subchondral bone and in the tibial metaphysis. The measure of heterogeneity at the tibial plateaux was the ratio of the standard deviation of the signal in the medial/lateral compartment to the standard deviation of the signal in the metaphysis (ratio of standard deviations--RSS(medial)/RSS(lateral)). Differences between groups were assessed using unpaired Student's t-tests.
  
  
  RESULTS
  Mean RSS(medial) was 2.61 (standard deviation, SD = 0.77) in group A and 2.97 (SD = 0.59) in group B. Mean RSS(lateral) in group A was 1.86 (SD = 0.63) and 1.89 (SD = 0.43) in group B. Mean total cartilage thickness (in mm) in group A was 3.38 (SD = 0.90) for the medial and 3.90 (SD = 1.09) for the lateral compartment and 3.44 (SD = 0.74) for the medial and 3.96 (SD = 0.96) for the lateral compartment in group B. The only parameter to show a statistically significant difference between groups was RSS(medial) (p = 0.04).
  
  
  CONCLUSIONS
  A difference in medial subchondral bone sclerosis between two age groups was demonstrated in the absence of MR features of OA. This may represent the earliest OA change detectable on MR imaging.
authors.affiliation: Department of Radiology, Norfolk & Norwich University Hospital, Norwich, UK, james.mackay@nnuh.nhs.uk.
authors.forename: James W
authors.initials: JW
authors.lastname: MacKay
authors.forename: Keith C
authors.initials: KC
authors.lastname: Godley
authors.forename: Andoni P
authors.initials: AP
authors.lastname: Toms
mesh_terms: D005260:Female; D006801:Humans; D007719:Knee Joint / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000473:pathology*; D015203:Reproducibility of Results; D012598:Sclerosis / Q000473:pathology; D012680:Sensitivity and Specificity; D013977:Tibia / Q000473:pathology*