title: Asymmetric Michael addition of α-fluoro-α-nitroalkanes to nitroolefins: facile preparation of fluorinated amines and tetrahydropyrimidines.
abstract: An asymmetric Michael addition of α-fluoro-α-nitroalkanes to nitroolefins was developed, and the products were obtained in good chemical yields and with high stereoselectivities. Highly functionalized adducts provided ready access to fluorinated amines and tetrahydropyrimidines in an optically enriched form.
authors.affiliation: Graduate School for Integrative Sciences & Engineering (NGS), Centre for Life Sciences (CeLS), National University of Singapore, #05-01, 28 Medical Drive, Singapore 117456. chmlyx@nus.edu.sg.
authors.forename: Jacek
authors.initials: J
authors.lastname: Kwiatkowski
authors.forename: Yixin
authors.initials: Y
authors.lastname: Lu
mesh_terms: D000473:Alkanes / Q000737:chemistry*; D000475:Alkenes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D018360:Crystallography, X-Ray; D005461:Fluorine / Q000737:chemistry*; D009584:Nitrogen / Q000737:chemistry*; D011743:Pyrimidines / Q000737:chemistry*
chemical_list: D000473:Alkanes; D000475:Alkenes; D000588:Amines; D011743:Pyrimidines; D005461:Fluorine; D009584:Nitrogen