title: Bovine herpesvirus type 1 marker vaccine induces cross-protection against bubaline herpesvirus type 1 in water buffalo.
abstract: Water buffalo (Bubalus bubalis) are susceptible to bovine herpesvirus type 1 (BoHV-1) and a species-specific herpesvirus, bubaline herpesvirus type 1 (BuHV-1). In this study, an attenuated marker BoHV-1 based vaccine against BuHV-1 challenge was evaluated to determine whether it induces protection from viral replication. One group of water buffalo calves was immunized with an attenuated BoHV-1 marker vaccine. A second group was not vaccinated and used as the control. During the post-vaccination period, we monitored the humoral immune response. The efficacy of the vaccine was tested after intranasal challenge of the calves with a BuHV-1 strain. The experiment showed that after vaccination, BuHV-1 replication was significantly reduced by approximately three titer points compared to the controls. The control animals showed high levels of viral shedding and mild signs associated with BuHV-1 infection. Therefore, our study provides evidence for the existence of cross-protection between BoHV-1 and BuHV-1 in buffalo calves.
authors.affiliation: Department of Veterinary Medicine and Animal Production, University of Naples "Federico II", Via Delpino no. 1, 80137 Naples, Italy. Electronic address: serena.montagnaro@unina.it.
authors.forename: Serena
authors.initials: S
authors.lastname: Montagnaro
authors.affiliation: Department of Veterinary Medicine and Animal Production, University of Naples "Federico II", Via Delpino no. 1, 80137 Naples, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: De Martinis
authors.affiliation: Department of Veterinary Medicine and Animal Production, University of Naples "Federico II", Via Delpino no. 1, 80137 Naples, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Iovane
authors.affiliation: Department of Veterinary Medicine and Animal Production, University of Naples "Federico II", Via Delpino no. 1, 80137 Naples, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Ciarcia
authors.affiliation: Department of Veterinary Medicine and Animal Production, University of Naples "Federico II", Via Delpino no. 1, 80137 Naples, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Damiano
authors.affiliation: Department of Veterinary Medicine and Animal Production, University of Naples "Federico II", Via Delpino no. 1, 80137 Naples, Italy.
authors.forename: Sandra
authors.initials: S
authors.lastname: Nizza
authors.affiliation: Department of Veterinary Medicine and Animal Production, University of Naples "Federico II", Via Delpino no. 1, 80137 Naples, Italy.
authors.forename: Luisa
authors.initials: L
authors.lastname: De Martino
authors.affiliation: Department of Veterinary Medicine and Animal Production, University of Naples "Federico II", Via Delpino no. 1, 80137 Naples, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Iovane
authors.affiliation: Department of Veterinary Medicine and Animal Production, University of Naples "Federico II", Via Delpino no. 1, 80137 Naples, Italy.
authors.forename: Ugo
authors.initials: U
authors.lastname: Pagnini
mesh_terms: D000818:Animals; D002020:Buffaloes; D056738:Cross Protection; D005260:Female; D006566:Herpesviridae Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary* / Q000821:virology; D007242:Herpesvirus 1, Bovine / Q000276:immunology / Q000502:physiology; D022283:Herpesvirus Vaccines / Q000276:immunology* / Q000627:therapeutic use; D008297:Male; D014613:Vaccines, Attenuated / Q000276:immunology / Q000627:therapeutic use; D022581:Vaccines, Marker / Q000276:immunology / Q000627:therapeutic use; D018140:Varicellovirus / Q000276:immunology* / Q000502:physiology; D014759:Viral Envelope Proteins / Q000276:immunology*; D014779:Virus Replication
chemical_list: D022283:Herpesvirus Vaccines; D014613:Vaccines, Attenuated; D022581:Vaccines, Marker; D014759:Viral Envelope Proteins
keywords: BoHV-1; BuHV-1; Marker vaccine; Water buffalo