title: C5-amino acid functionalized LNA: positively poised for antisense applications.
abstract: Incorporation of positively charged C5-amino acid functionalized LNA uridines into oligodeoxyribonucleotides (ONs) results in extraordinary RNA affinity, binding specificity and stability towards 3'-exonucleases.
authors.affiliation: Department of Chemistry, University of Idaho, 875 Perimeter Drive MS2343, Moscow, ID 83844-2343, USA. hrdlicka@uidaho.edu.
authors.forename: Dale C
authors.initials: DC
authors.lastname: Guenther
authors.forename: Pawan
authors.initials: P
authors.lastname: Kumar
authors.forename: Brooke A
authors.initials: BA
authors.lastname: Anderson
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Hrdlicka
mesh_terms: D041721:3T3-L1 Cells; D000596:Amino Acids / Q000737:chemistry; D000818:Animals; D005092:Exonucleases / Q000737:chemistry; D049409:Luciferases, Firefly / Q000235:genetics; D051379:Mice; D020319:Oligodeoxyribonucleotides, Antisense / Q000737:chemistry* / Q000494:pharmacology; D009841:Oligonucleotides / Q000737:chemistry* / Q000494:pharmacology; D043264:Phosphodiesterase I / Q000737:chemistry; D012313:RNA / Q000737:chemistry / Q000235:genetics; D014529:Uridine / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000596:Amino Acids; D020319:Oligodeoxyribonucleotides, Antisense; D009841:Oligonucleotides; C477371:locked nucleic acid; D012313:RNA; D049409:Luciferases, Firefly; D005092:Exonucleases; C022650:spleen exonuclease; D043264:Phosphodiesterase I; C470790:phosphodiesterase I, snake venom; D014529:Uridine