title: [Conservation and destruction of autologous and allogeneic cryopreserved cellular products: recommendations from the SFGM-TC].
abstract: Thousands of autologous and at less extent allogeneic hematopoietic stem cells (HSC) bags are cryopreserved in France. The majority of autologous HSC grafts are used within a year after collection. However, many bags are still unused and cryopreserved for many years. In France and on a European scale, the ever-growing number of cryopreserved bags represents a real economic health concern. Indeed, the cost of storage is about 100€ per bag and per year. In addition, quality and therapeutic value of these long-term cryopreserved grafts needs to be evaluated. In the attempt to harmonize clinical practices between different French transplantation centers, the French Society of Bone Marrow Transplantation and Cell Therapies (SFGM-TC) set up its fourth annual series of workshops which brought together practitioners from its member centers across France. These workshops took place in September 2013 in Lille. In this article, we addressed the issue of the destruction of long-term cryopreserved grafts be them autologous or allogeneic and provide recommendations regarding their destruction.
authors.affiliation: Centre de thérapie cellulaire et génique, institut Paoli-Calmettes, 232, boulevard Sainte-Marguerite, BP 156, 13273 Marseille cedex 09, France; EFS centre atlantique, site de Poitiers, 350, avenue Jacques-Cœur, BP 482, 86012 Poitiers cedex, France.
authors.forename: B
authors.initials: B
authors.lastname: Calmels
authors.affiliation: EFS Nord de France, laboratoire de thérapie cellulaire, 96, rue de Jemmapes, CS 22018, 59013 Lille cedex, France; EFS centre atlantique, site de Poitiers, 350, avenue Jacques-Cœur, BP 482, 86012 Poitiers cedex, France.
authors.forename: F
authors.initials: F
authors.lastname: Boulanger
authors.affiliation: Laboratoire de thérapie cellulaire et génique, CHU de Liège, Tour 2 niveau -4(E), 4000 Liège, Belgique; EFS centre atlantique, site de Poitiers, 350, avenue Jacques-Cœur, BP 482, 86012 Poitiers cedex, France.
authors.forename: E
authors.initials: E
authors.lastname: Baudoux
authors.affiliation: Unité de thérapie cellulaire et banque de tissus, CHU Nancy-Brabois, rue du Morvan, 54511 Vandœuvre-lès-Nancy cedex, France; EFS centre atlantique, site de Poitiers, 350, avenue Jacques-Cœur, BP 482, 86012 Poitiers cedex, France.
authors.forename: V
authors.initials: V
authors.lastname: Decot
authors.affiliation: Service hématologie clinique, hôpital Victor-Provo, boulevard Lacordaire, 59100 Roubaix, France; EFS centre atlantique, site de Poitiers, 350, avenue Jacques-Cœur, BP 482, 86012 Poitiers cedex, France.
authors.forename: A
authors.initials: A
authors.lastname: Fawaz
authors.affiliation: CHU de Poitiers, 2, rue de La-Milétrie, BP 577, 86021 Poitiers cedex, France; EFS centre atlantique, site de Poitiers, 350, avenue Jacques-Cœur, BP 482, 86012 Poitiers cedex, France.
authors.forename: C
authors.initials: C
authors.lastname: Giraud
authors.affiliation: EFS centre atlantique, site de Poitiers, 350, avenue Jacques-Cœur, BP 482, 86012 Poitiers cedex, France; Maladies du sang, CHRU de Lille, rue Michel-Polonovski, 59037 Lille cedex, France.
authors.forename: B
authors.initials: B
authors.lastname: Hivert
authors.affiliation: EFS centre atlantique, site de Poitiers, 350, avenue Jacques-Cœur, BP 482, 86012 Poitiers cedex, France; Inserm, UMR_S 938, proliferation and differentiation of stem cells, hôpital Saint-Antoine, AP-HP, 75012 Paris, France; Département d'hématologie et de thérapie cellulaire, université Pierre et Marie-Curie Paris 6, 75012 Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Garderet
authors.affiliation: EFS centre atlantique, site de Poitiers, 350, avenue Jacques-Cœur, BP 482, 86012 Poitiers cedex, France; Service des maladies du sang, G.H. du Haut Levêque, avenue de Magellan, 33604 Pessac, France.
authors.forename: N
authors.initials: N
authors.lastname: Milpied
authors.affiliation: EFS centre atlantique, site de Poitiers, 350, avenue Jacques-Cœur, BP 482, 86012 Poitiers cedex, France; Maladies du sang, CHRU de Lille, rue Michel-Polonovski, 59037 Lille cedex, France. Electronic address: sfgm-tc-iya@live.fr.
authors.forename: I
authors.initials: I
authors.lastname: Yakoub-Agha
mesh_terms: D003365:Costs and Cost Analysis; D015925:Cryopreservation / Q000191:economics; D005602:France; D018380:Hematopoietic Stem Cell Transplantation / Q000592:standards; D006412:Hematopoietic Stem Cells; D006801:Humans; D017744:Medical Waste Disposal; D011786:Quality Control; D012042:Registries; D013997:Time Factors; D014184:Transplantation, Homologous
chemical_list: D017744:Medical Waste Disposal
keywords: Consentement; Cryopreserved cell product; Destruction; Disposal; Informed consent; Produit cellulaire cryopréservé; Stockage; Storage