title: Decreased plasma nesfatin-1 level is related to the thyroid dysfunction in patients with type 2 diabetes mellitus.
abstract: OBJECTIVE
  Thyroid dysfunction is frequently observed in patients with type 2 diabetes mellitus (T2DM), but the underlying mechanism is still poorly understood. The present study aimed to investigate whether nesfatin-1 played a role in the thyroid dysfunction in patients with T2DM.
  
  
  METHODS
  55 euthyroid patients were enrolled in this study including 30 patients with T2DM and 25 patients with impaired glucose regulation (IGR). 30 age-matched healthy people were also included as the control. The plasma levels of nesfatin-1, thyrotropin (TSH), and glycosylated hemoglobin (HbA1c) as well as the body mass index (BMI) were comparatively analyzed among the three groups.
  
  
  RESULTS
  The nesfatin-1 was significantly lower in patients with T2DM than in patients with IGR and in the control. On the contrary, the TSH level was significantly higher in patients with T2DM than in patients with IGR and in the control. Simple regression analysis showed that the plasma nesfatin-1 was negatively correlated with the TSH and HbA1c levels and positively correlated with the BMI. With multiple stepwise regression analysis, the nesfatin-1 remained to be independently correlated with the TSH, BMI, and HbA1c.
  
  
  CONCLUSIONS
  The study was suggesting a role of nesfatin-1 in thyroid dysfunction in patients with T2DM.
authors.affiliation: Department of Endocrinology, Central People's Hospital of Tengzhou City, Tengzhou, Shandong 277500, China.
authors.forename: Fupeng
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Medicine, Maternal and Child Care Service Centre of Tengzhou City, Tengzhou, Shandong 277500, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Department of Endocrinology, Qianfoshan Hospital of Shandong University, Jinan, Shandong 250000, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Gao
authors.affiliation: Department of Endocrinology, Qianfoshan Hospital of Shandong University, Jinan, Shandong 250000, China.
authors.forename: Fangfang
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, Qianfoshan Hospital of Shandong University, Jinan, Shandong 250000, China.
authors.forename: Shaohua
authors.identifier: 0000-0001-6115-4925
authors.initials: S
authors.lastname: Chen
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002135:Calcium-Binding Proteins / Q000097:blood*; D004268:DNA-Binding Proteins / Q000097:blood*; D048909:Diabetes Complications / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D005786:Gene Expression Regulation; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008564:Membrane Potentials; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000097:blood*; D000080866:Nucleobindins; D013959:Thyroid Diseases / Q000097:blood* / Q000150:complications*; D013961:Thyroid Gland / Q000503:physiopathology; D013972:Thyrotropin / Q000097:blood
chemical_list: D001786:Blood Glucose; D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; D006442:Glycated Hemoglobin; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins; D013972:Thyrotropin; C000630650:NUCB2 protein, human