title: Sequencing-based approach identified three new susceptibility loci for psoriasis.
abstract: In a previous large-scale exome sequencing analysis for psoriasis, we discovered seven common and low-frequency missense variants within six genes with genome-wide significance. Here we describe an in-depth analysis of noncoding variants based on sequencing data (10,727 cases and 10,582 controls) with replication in an independent cohort of Han Chinese individuals consisting of 4,480 cases and 6,521 controls to identify additional psoriasis susceptibility loci. We confirmed four known psoriasis susceptibility loci (IL12B, IFIH1, ERAP1 and RNF114; 2.30 × 10(-20)≤P≤2.41 × 10(-7)) and identified three new susceptibility loci: 4q24 (NFKB1) at rs1020760 (P=2.19 × 10(-8)), 12p13.3 (CD27-LAG3) at rs758739 (P=4.08 × 10(-8)) and 17q12 (IKZF3) at rs10852936 (P=1.96 × 10(-8)). Two suggestive loci, 3p21.31 and 17q25, are also identified with P<1.00 × 10(-6). The results of this study increase the number of confirmed psoriasis risk loci and provide novel insight into the pathogenesis of psoriasis.
authors.affiliation: 1] Department of Dermatology, No. 2 Hospital, Anhui Medical University, Hefei, Anhui 230601, China [2] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [3] Department of Dermatology, Huashan Hospital of Fudan University, Shanghai 200040, China [4].
authors.forename: Yujun
authors.initials: Y
authors.lastname: Sheng
authors.affiliation: 1] BGI-Shenzhen, Shenzhen 518083, China [2] School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 518055, China [3].
authors.forename: Xin
authors.initials: X
authors.lastname: Jin
authors.affiliation: 1] Department of Dermatology, Huashan Hospital of Fudan University, Shanghai 200040, China [2].
authors.forename: Jinhua
authors.initials: J
authors.lastname: Xu
authors.affiliation: 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui 230032, China [4].
authors.forename: Jinping
authors.initials: J
authors.lastname: Gao
authors.affiliation: 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui 230032, China.
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Du
authors.affiliation: 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui 230032, China.
authors.forename: Dawei
authors.initials: D
authors.lastname: Duan
authors.affiliation: 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui 230032, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Li
authors.affiliation: 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui 230032, China.
authors.forename: Jinhua
authors.initials: J
authors.lastname: Zhao
authors.affiliation: 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui 230032, China.
authors.forename: Wenying
authors.initials: W
authors.lastname: Zhan
authors.affiliation: 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui 230032, China.
authors.forename: Huayang
authors.initials: H
authors.lastname: Tang
authors.affiliation: 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui 230032, China.
authors.forename: Xianfa
authors.initials: X
authors.lastname: Tang
authors.affiliation: 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui 230032, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.affiliation: 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui 230032, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Cheng
authors.affiliation: 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui 230032, China.
authors.forename: Xianbo
authors.initials: X
authors.lastname: Zuo
authors.affiliation: BGI-Shenzhen, Shenzhen 518083, China.
authors.forename: Junpu
authors.initials: J
authors.lastname: Mei
authors.affiliation: 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui 230032, China.
authors.forename: Fusheng
authors.initials: F
authors.lastname: Zhou
authors.affiliation: 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui 230032, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Liang
authors.affiliation: 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui 230032, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.affiliation: 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui 230032, China.
authors.forename: Changbing
authors.initials: C
authors.lastname: Shen
authors.affiliation: 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui 230032, China.
authors.forename: Hongzhou
authors.initials: H
authors.lastname: Cui
authors.affiliation: 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui 230032, China.
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: Zhang
authors.affiliation: 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui 230032, China.
authors.forename: Change
authors.initials: C
authors.lastname: Zhang
authors.affiliation: 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui 230032, China.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Wang
authors.affiliation: 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui 230032, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Zheng
authors.affiliation: 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui 230032, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Fan
authors.affiliation: 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui 230032, China.
authors.forename: Zaixing
authors.initials: Z
authors.lastname: Wang
authors.affiliation: 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui 230032, China.
authors.forename: Fengli
authors.initials: F
authors.lastname: Xiao
authors.affiliation: 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui 230032, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Cui
authors.affiliation: BGI-Shenzhen, Shenzhen 518083, China.
authors.forename: Yingrui
authors.initials: Y
authors.lastname: Li
authors.affiliation: 1] BGI-Shenzhen, Shenzhen 518083, China [2] Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark [3] Department of Biology, University of Copenhagen, DK-2200 Copenhagen N, Denmark.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui 230032, China.
authors.forename: Sen
authors.initials: S
authors.lastname: Yang
authors.affiliation: Department of Computer Science and Engineering, Rm1028 Ho Sin-Hang Engineering Building, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Xu
authors.affiliation: 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui 230032, China.
authors.forename: Liangdan
authors.initials: L
authors.lastname: Sun
authors.affiliation: 1] Department of Dermatology, No. 2 Hospital, Anhui Medical University, Hefei, Anhui 230601, China [2] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [3] Department of Dermatology, Huashan Hospital of Fudan University, Shanghai 200040, China [4] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [5] Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui 230032, China.
authors.forename: Xuejun
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D051740:Ikaros Transcription Factor / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D052002:NF-kappa B p50 Subunit / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011565:Psoriasis / Q000235:genetics*; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000235:genetics*; D055815:Young Adult; D000093322:Lymphocyte Activation Gene 3 Protein
chemical_list: D015703:Antigens, CD; C106285:IKZF3 protein, human; D052002:NF-kappa B p50 Subunit; C489548:NFKB1 protein, human; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7; D051740:Ikaros Transcription Factor; D000093322:Lymphocyte Activation Gene 3 Protein; C000720326:Lag3 protein, human