title: Does race alter the relationship between Hba1c and glucose in type 2 diabetes?
abstract: OBJECTIVE
  Hemoglobin Alc (HbAlc) is the standard measurement of glycemic control, and the HbAlc value can be used to estimate average glucose using a formula. Several studies suggest that the relationship between average glucose and HbAlc may be different for Blacks. This project enrolled non-Hispanic black and white individuals with type 2 diabetes and evaluated the relationship between HbAlc and blood glucose.
  
  
  METHODS
  22 black and 29 white adults with type 2 diabetes were included in the analysis. Approximately 42 measurements (fasting and postprandial glucose) were collected over three months and compared to HbAl1 of the third month. The effect of race was evaluated by ANCOVA and X2 analysis testing the slope and intercepts simultaneously for HbA1c and its relationship to fasting glucose and to postprandial glucose.
  
  
  RESULTS
  The relationship between HbAlc and glucose was not statistically significantly different between Blacks and Whites (ANCOVA: P = 0.968 for fasting glucose, P = 0.428 for postprandial glucose), allowing us to calculate estimated fasting and postprandial glucose disregarding race. For fasting glucose, the linear regression is FGmgiadl = (18.939 X HbAlc%) - 1.864, R2 = 0.586, P < 0.0001. For postprandial glucose, the linear regression is In(PPG mg,dl) (1.261 X In(HbA1c%)) + 2.555, R2 = 0.614, P < 0.0001. Predicted values for postprandial glucose based on HbA1c were similar to estimated average glucose values reported by ADAG.
  
  
  CONCLUSIONS
  This study reinforces the A1c-Derived Average Glucose (ADAG) group finding that the relationship between HbA1c and glucose is similar in non-Hispanic black and white adults with type 2 diabetes.
authors.forename: Kristina Jackson
authors.initials: KJ
authors.lastname: Behan
authors.forename: Justice
authors.initials: J
authors.lastname: Mbizo
authors.forename: Michael A
authors.initials: MA
authors.lastname: Johnston
authors.forename: Marcia
authors.initials: M
authors.lastname: Dumas
authors.forename: Marisa C
authors.initials: MC
authors.lastname: Yates
mesh_terms: D000368:Aged; D044383:Black People; D001786:Blood Glucose / Q000378:metabolism*; D002648:Child; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology* / Q000378:metabolism*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D044465:White People
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human