title: Measles virus takes a two-pronged attack on PP1.
abstract: During viral infection, RIG-I-like receptors (RLRs) are activated upon dephosphorylation by the phosphatase PP1, resulting in type I interferon production. In this issue, Davis et al. (2014) and Mesman et al. (2014) show that measles virus inhibits this antiviral response by targeting PP1 and thus preventing RLR dephosphorylation and activation.
authors.affiliation: Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University Kita-ku, Kita-15, Nishi-7, Sapporo 060-8638, Japan. Electronic address: seya-tu@pop.med.hokudai.ac.jp.
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Seya
mesh_terms: D015815:Cell Adhesion Molecules / Q000378:metabolism*; D053487:DEAD-box RNA Helicases / Q000378:metabolism*; D003713:Dendritic Cells / Q000276:immunology*; D054884:Host-Pathogen Interactions; D006801:Humans; D057131:Immune Evasion; D037181:Lectins, C-Type / Q000378:metabolism*; D008459:Measles virus / Q000276:immunology* / Q000502:physiology*; D010750:Phosphoproteins / Q000378:metabolism*; D054645:Protein Phosphatase 1 / Q000037:antagonists & inhibitors*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D014764:Viral Proteins / Q000378:metabolism*
chemical_list: D015815:Cell Adhesion Molecules; D037181:Lectins, C-Type; D010750:Phosphoproteins; D011956:Receptors, Cell Surface; D014764:Viral Proteins; D054645:Protein Phosphatase 1; D053487:DEAD-box RNA Helicases