title: Cu(II)-catalyzed asymmetric boron conjugate addition to α,β-unsaturated imines in water.
abstract: Enantioselective conjugate addition of bis(pinacolato)diboron to α,β-unsaturated imines proceeds smoothly in water in the presence of a chiral copper(II) complex consisting of Cu(OAc)2 and chiral 2,2'-bipyridine. The corresponding β-boryl imines, which were oxidized to β-hydroxy imines, further leading to γ-amino alcohols, were obtained in high yields and high enantioselectivities.
authors.affiliation: Deparment of Chemistry, School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan. shu_kobayashi@chem.s.u-tokyo.ac.jp.
authors.forename: Taku
authors.initials: T
authors.lastname: Kitanosono
authors.forename: Pengyu
authors.initials: P
authors.lastname: Xu
authors.forename: Satoshi
authors.initials: S
authors.lastname: Isshiki
authors.forename: Lei
authors.initials: L
authors.lastname: Zhu
authors.forename: Shū
authors.initials: S
authors.lastname: Kobayashi
mesh_terms: D001895:Boron / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003461:Crystallography; D007097:Imines / Q000737:chemistry*; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry*
chemical_list: D007097:Imines; D014867:Water; D003300:Copper; D001895:Boron