title: Mathematical model of neuronal morphology: prenatal development of the human dentate nucleus.
abstract: The aim of the study was to quantify the morphological changes of the human dentate nucleus during prenatal development using mathematical models that take into account main morphometric parameters. The camera lucida drawings of Golgi impregnated neurons taken from human fetuses of gestational ages ranging from 14 to 41 weeks were analyzed. Four morphometric parameters, the size of the neuron, the dendritic complexity, maximum dendritic density, and the position of maximum density, were obtained using the modified Scholl method and fractal analysis. Their increase during the entire prenatal development can be adequately fitted with a simple exponential. The three parameters describing the evolution of branching complexity of the dendritic arbor positively correlated with the increase of the size of neurons, but with different rate constants, showing that the complex development of the dendritic arbor is complete during the prenatal period. The findings of the present study are in accordance with previous crude qualitative data on prenatal development of the human dentate nucleus, but provide much greater amount of fine details. The mathematical model developed here provides a sound foundation enabling further studies on natal development or analyzing neurological disorders during prenatal development.
authors.affiliation: Laboratory for Image Analysis, Medical Faculty, University of Belgrade, Serbia.
authors.forename: Katarina
authors.initials: K
authors.lastname: Rajković
authors.affiliation: Faculty of Physical Chemistry, University of Belgrade, Serbia.
authors.forename: Goran
authors.initials: G
authors.lastname: Bačić
authors.affiliation: Department of Biophysics, Medical Faculty, University of Belgrade, KCS Institute of Biophysics PP. 22, 11129 Belgrade, Serbia.
authors.forename: Dušan
authors.initials: D
authors.lastname: Ristanović
authors.affiliation: Laboratory for Image Analysis, Medical Faculty, University of Belgrade, Serbia ; Department of Biophysics, Medical Faculty, University of Belgrade, KCS Institute of Biophysics PP. 22, 11129 Belgrade, Serbia.
authors.forename: Nebojša T
authors.initials: NT
authors.lastname: Milošević
mesh_terms: D002529:Cerebellar Nuclei / Q000196:embryology*; D003712:Dendrites; D047108:Embryonic Development; D006801:Humans; D008962:Models, Theoretical; D009474:Neurons