title: Clinical assessment of post-adulticide complications in Dirofilaria immitis-naturally infected dogs treated with doxycycline and ivermectin.
abstract: This study shows that a combination of doxycycline (10mg/kg/sid for 30 days) and ivermectin (6 μg/kg/every 15 days for 6 months) is well tolerated for the treatment of canine heartworm disease (HWD). Monthly echocardiography showed that 84% of treated dogs either progressively improved parameters indicative of pulmonary hypertension or, following slight worsening, resolved all signs. Thoracic radiography showed the persistence of interstitial inflammation, even though also in this case, approximately 70% of the dogs steadily improved or worsened but then improved by the end of the study.
authors.affiliation: Department of Veterinary Sciences, University of Parma, Via del Taglio 10, Parma 43126, Italy.
authors.forename: Antonia
authors.initials: A
authors.lastname: Mavropoulou
authors.affiliation: Department of Veterinary Sciences, University of Parma, Via del Taglio 10, Parma 43126, Italy.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Gnudi
authors.affiliation: Department of Veterinary Sciences, University of Parma, Via del Taglio 10, Parma 43126, Italy.
authors.forename: Giulio
authors.initials: G
authors.lastname: Grandi
authors.affiliation: Department of Veterinary Sciences, University of Parma, Via del Taglio 10, Parma 43126, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Volta
authors.affiliation: Department of Veterinary Sciences, University of Parma, Via del Taglio 10, Parma 43126, Italy. Electronic address: kramerlh@unipr.it.
authors.forename: Laura H
authors.initials: LH
authors.lastname: Kramer
authors.affiliation: Department of Veterinary Sciences, University of Parma, Via del Taglio 10, Parma 43126, Italy.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Quintavalla
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000977:Antiparasitic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D004183:Dirofilaria immitis; D004184:Dirofilariasis / Q000188:drug therapy* / Q000473:pathology; D004283:Dog Diseases / Q000188:drug therapy / Q000469:parasitology*; D004285:Dogs; D004318:Doxycycline / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D007559:Ivermectin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D009206:Myocardium / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000502:physiology*
chemical_list: D000900:Anti-Bacterial Agents; D000977:Antiparasitic Agents; D007559:Ivermectin; D004318:Doxycycline
keywords: Cardiac ultrasound; Dirofilaria immitis; Doxycycline; Ivermectin; Melarsomine