title: Design and synthesis of (S)- and (R)-α-(phenyl)ethylamine-derived NH-type ligands and their application for the chemical resolution of α-amino acids.
abstract: This work presents the first chemical approach for the resolution of α-amino acids offering the following advantages: (1) The specially designed resolving reagent is derived from α-(phenyl)ethylamine, the most inexpensive chiral auxiliary, which can be recycled and reused, rendering the cost structure of the complete process very attractive; (2) the time-efficient two-step process can be conducted under operationally convenient conditions with virtually quantitative yields; and (3) the process can readily be adapted to large-scale use.
authors.affiliation: Hamari Chemicals Ltd, 1-4-29 Kunijima, Higashi-Yodogawa-ku, Osaka, Japan 533-0024.
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Takeda
authors.forename: Akie
authors.initials: A
authors.lastname: Kawamura
authors.forename: Aki
authors.initials: A
authors.lastname: Kawashima
authors.forename: Hiroki
authors.initials: H
authors.lastname: Moriwaki
authors.forename: Tatsunori
authors.initials: T
authors.lastname: Sato
authors.forename: José Luis
authors.initials: JL
authors.lastname: Aceña
authors.forename: Vadim A
authors.initials: VA
authors.lastname: Soloshonok
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D018360:Crystallography, X-Ray; D005998:Glycine / Q000737:chemistry; D008024:Ligands; D010627:Phenethylamines / Q000138:chemical synthesis* / Q000737:chemistry*; D012545:Schiff Bases / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D008024:Ligands; D010627:Phenethylamines; D012545:Schiff Bases; D005998:Glycine