title: Mitochondrial function in melanoma.
abstract: Melanoma is the most lethal form of skin cancer and its incidence is rapidly rising. Breakthroughs in the understanding of the basic biology of melanoma in the past decade have yielded several new treatments, and advances continue to be made on a variety of fronts. One such area involves the delineation of changes in mitochondria that occur during melanoma formation, and how these changes affect responses to therapy. In this review, we summarize recent developments on the multiple functions that mitochondria play in melanoma, and how these roles are currently being evaluated as new targets for clinical intervention.
authors.affiliation: Department of Pathology, Yale University School of Medicine, New Haven, CT, United States. Electronic address: nicholas.theodosakis@yale.edu.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Theodosakis
authors.affiliation: Department of Pathology, Yale University School of Medicine, New Haven, CT, United States.
authors.forename: Goran
authors.initials: G
authors.lastname: Micevic
authors.affiliation: Sanford-Burnham Medical Research Institute, Lake Nona, FL, United States.
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Kelly
authors.affiliation: Department of Pathology, Yale University School of Medicine, New Haven, CT, United States; Department of Dermatology, Yale University School of Medicine, New Haven, CT, United States.
authors.forename: Marcus
authors.initials: M
authors.lastname: Bosenberg
mesh_terms: D000818:Animals; D017209:Apoptosis; D004734:Energy Metabolism; D006801:Humans; D008545:Melanoma / Q000209:etiology / Q000378:metabolism*; D053858:Metabolic Networks and Pathways; D051739:Microphthalmia-Associated Transcription Factor / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism*; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D017382:Reactive Oxygen Species / Q000378:metabolism; D012878:Skin Neoplasms / Q000209:etiology / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D051739:Microphthalmia-Associated Transcription Factor; C486497:PPARGC1A protein, human; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D017382:Reactive Oxygen Species; D014157:Transcription Factors
keywords: Apoptosis; MITF; Melanoma; Metabolism; Mitochondria; PGC-1