title: [A role of diencephalic monoaminergic dysfunction in chronic neurogenic pain].
abstract: Changes in catecholamine pool (epinephrine, norepinephrine, dopamine) and 5-oxyindoles (serotonin, 5-oxyindolacetic acid) in the diencephalic structures were studied in 2, 15, 40 days of neurogenic pain syndrome development in rats with double-sided entrapment of N. ischiadicus. The main manifestations of monoamine diencephalic dysfunction in the period of neurogenic pain chronization were described: the reduction of catecholamine pool, most evident in the thalamus; absolute and relative serotonin increase (especially in the hypothalamus); "minimization" of thalamus monoamine potential and shift of diencephalic balance to the hypothalamic MA-ergic component domination. The possible mechanisms of the imbalance and its role in the deformation of noci-antinociceptive interaction in the neurogenic pain process are discussed.
authors.forename: A V
authors.initials: AV
authors.lastname: Kapliev
authors.forename: I M
authors.initials: IM
authors.lastname: Kotieva
mesh_terms: D000818:Animals; D002395:Catecholamines / Q000502:physiology*; D059350:Chronic Pain / Q000503:physiopathology*; D004027:Diencephalon / Q000503:physiopathology*; D008297:Male; D009437:Neuralgia / Q000503:physiopathology*; D051381:Rats
chemical_list: D002395:Catecholamines