title: One-pot synthesis and functionalisation of Fe2O3@C-NH2 nanoparticles for imaging and therapy.
abstract: The authors have prepared amine-modified Fe2O3@C nanoparticles with diameter of 20 nm by decomposing perchlorinated pyrene/Fe(NO3)3 mixture in the presence of ammonia in solvothermal conditions at 180°C for 48 h by a one-step process. NH3 is not only a cocatalyst of Fe(NO3)3 for decomposition of perchlorinated pyrene, but also the source of surface functionalisation group. The effect of synthesis conditions on shape and size of nanoparticles and characterisation of their structure and functionalisation group are investigated in this research. The amino group in the surface of core-shell nanoparticles can be further functionalised with polyethylene glycol and folic acid to improve their solubility in aqueous solution and target cancer cells. The applications of functionalised core-shell nanoparticles in magnetic resonance imaging and cancer thermal therapy are also investigated in this research.
authors.affiliation: Department of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, People's Republic of China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, People's Republic of China.
authors.forename: Jiabao
authors.initials: J
authors.lastname: Ding
authors.affiliation: Department of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, People's Republic of China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, People's Republic of China.
authors.forename: Kai
authors.initials: K
authors.lastname: Wei
authors.affiliation: Department of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, People's Republic of China. jweng@xmu.edu.cn.
authors.forename: Jian
authors.initials: J
authors.lastname: Weng
authors.affiliation: Department of Imaging, Zhongshan Hospital, Xiamen University, Xiamen 361005, People's Republic of China.
authors.forename: Jinan
authors.initials: J
authors.lastname: Wang
mesh_terms: D000588:Amines / Q000138:chemical synthesis*; D002384:Catalysis; D045744:Cell Line, Tumor; D005290:Ferric Compounds / Q000737:chemistry*; D005492:Folic Acid / Q000737:chemistry; D006358:Hot Temperature; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008279:Magnetic Resonance Imaging; D053768:Metal Nanoparticles / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D050997:Nanomedicine / Q000295:instrumentation* / Q000379:methods; D037742:Nanotubes, Carbon / Q000737:chemistry; D009369:Neoplasms / Q000628:therapy; D011092:Polyethylene Glycols / Q000737:chemistry; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D013499:Surface Properties; D013696:Temperature; D013997:Time Factors
chemical_list: D000588:Amines; D005290:Ferric Compounds; D037742:Nanotubes, Carbon; D012997:Solvents; C000499:ferric oxide; D011092:Polyethylene Glycols; D005492:Folic Acid