title: Syntheses of fluorooxindole and 2-fluoro-2-arylacetic acid derivatives from diethyl 2-fluoromalonate ester.
abstract: Diethyl 2-fluoromalonate ester is utilised as a building block for the synthesis of 2-fluoro-2-arylacetic acid and fluorooxindole derivatives by a strategy involving nucleophilic aromatic substitution reactions with ortho-fluoronitrobenzene substrates followed by decarboxylation, esterification and reductive cyclisation processes.
authors.affiliation: Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK.
authors.forename: Antal
authors.initials: A
authors.lastname: Harsanyi
authors.affiliation: Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK.
authors.forename: Graham
authors.initials: G
authors.lastname: Sandford
authors.affiliation: Chemical Crystallography, Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK.
authors.forename: Dmitri S
authors.initials: DS
authors.lastname: Yufit
authors.affiliation: Chemical Crystallography, Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK.
authors.forename: Judith Ak
authors.initials: JA
authors.lastname: Howard
keywords: fluorinated building blocks; fluoroarylacetic acid; fluoromalonate; fluorooxindole; organo-fluorine; selective fluorination