title: [Chemo-preventive effect of Angelica sinensis' supercritical extracts on AOM/DSS-induced mouse colorectal carcinoma associated with inflammation].
abstract: To study the chemo-preventive effect of the supercritical extracts from Angelica sinensis (SFE-AS) on induced colorectal carcinoma in mice by using the AOM/DSS-induced male mice colorectal carcinoma model, and discuss its possible action mechanism. Male Balb/c mice were subcutaneously injected with single dose of azoxymethane (AOM, 10 mg x kg(-1) body weight). One week later, they were given 2% dextran sodium sulfate (DSS) in drinking water for 7 days to induce colorectal carcinoma. Each drug group was orally administered with supercritical extracts from Angelica sinensis at 15, 30, 60 mg x kg(-1) until the 17th week. The tumor incidence rate of the SFE-AS group, mice tumor-bearing quantity and tumor-bearing volume of the SFE-AS group were lower than that of the AOM/DSS model control group, which may be related with the significant reduction of PCNA, COX-2, iNOS in the AOM/DSS-induced mouse colorectal carcinoma model associated with inflammation by SFE-AS. According to the results of this study, SFE-AS showed an intervention effect in the incidence and development of AOM/DSS-induced mouse colorectal carcinoma associated with inflammation, and could be further used in chemo-preventive studies on human colorectal carcinoma.
authors.forename: Jing
authors.initials: J
authors.lastname: An
authors.forename: Xiao-Ning
authors.initials: XN
authors.lastname: Li
authors.forename: Bo-Chen
authors.initials: BC
authors.lastname: Zhao
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wang
authors.forename: Yi
authors.initials: Y
authors.lastname: Lan
authors.forename: Qing
authors.initials: Q
authors.lastname: Wu
mesh_terms: D029971:Angelica sinensis / Q000737:chemistry*; D000818:Animals; D001397:Azoxymethane / Q000009:adverse effects; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000235:genetics / Q000276:immunology / Q000517:prevention & control*; D015179:Colorectal Neoplasms / Q000139:chemically induced / Q000235:genetics / Q000276:immunology / Q000517:prevention & control*; D051546:Cyclooxygenase 2 / Q000235:genetics / Q000378:metabolism; D016264:Dextran Sulfate / Q000009:adverse effects; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D018809:Proliferating Cell Nuclear Antigen / Q000235:genetics / Q000276:immunology
chemical_list: D004365:Drugs, Chinese Herbal; D018809:Proliferating Cell Nuclear Antigen; D016264:Dextran Sulfate; D051546:Cyclooxygenase 2; D001397:Azoxymethane