title: Hemolytic uremic syndrome with mild renal involvement due to Shiga toxin-producing Escherichia coli (STEC) O145 strain.
abstract: Hemolytic uremic syndrome (HUS) is a disorder characterized by the presence of the classic triad: microangiopathic hemolytic anemia, thrombocytopenia and acute renal injury. HUS without acute renal failure can be confused with other hematologic diseases. An infantile HUS caused by a Shiga-toxin-producing Escherichia coli (STEC) O145 strain carrying genotype stx2, ehxA, eae subtype β1 is herein reported. The infant did not require dialysis during the acute stage of HUS, evolved favorably, maintained normal blood pressure and normal renal function and had no recurrence until the last control. This could be due to several factors, such as the characteristics of infecting STEC strain and a reduction in host susceptibility to renal injury. This report highlights the regional participation of non-O157 STEC in childhood diseases and the importance of performing active surveillance for all forms of HUS.
authors.affiliation: Departamento de Bacteriología y Virología, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
authors.forename: Lucía
authors.initials: L
authors.lastname: Pérez
authors.affiliation: Mutualista Médica Uruguaya, Montevideo, Uruguay.
authors.forename: Lucía
authors.initials: L
authors.lastname: Apezteguía
authors.affiliation: Mutualista Médica Uruguaya, Montevideo, Uruguay.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Piñeyrúa
authors.affiliation: Mutualista Médica Uruguaya, Montevideo, Uruguay.
authors.forename: Agustín
authors.initials: A
authors.lastname: Dabezies
authors.affiliation: Departamento de Bacteriología y Virología, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
authors.forename: María N
authors.initials: MN
authors.lastname: Bianco
authors.affiliation: Departamento de Bacteriología y Virología, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
authors.forename: Felipe
authors.initials: F
authors.lastname: Schelotto
authors.affiliation: Departamento de Bacteriología y Virología, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay. Electronic address: gvarela@higiene.edu.uy.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Varela
mesh_terms: D004927:Escherichia coli Infections / Q000150:complications*; D006463:Hemolytic-Uremic Syndrome / Q000382:microbiology*; D006801:Humans; D007223:Infant; D007674:Kidney Diseases / Q000382:microbiology*; D008297:Male; D012720:Severity of Illness Index; D054323:Shiga-Toxigenic Escherichia coli
keywords: Esquizocitos; Falla renal; HUS; Non-O157 STEC; Renal failure; STEC no-O157; SUH; Schizocytes