title: An evaluation of the sensitivity of MRI at detecting hepatocellular carcinoma in cirrhotic patients utilizing an explant reference standard.
abstract: OBJECTIVE
  To evaluate the sensitivity of magnetic resonance imaging (MRI) at detecting hepatocellular carcinoma (HCC).
  
  
  METHODS
  MRIs performed within 120 days of transplant, and pathology, were reviewed.
  
  
  RESULTS
  Of the 87 patients included in the final analysis, 58 had HCC at explant (106 total HCCs). The per-patient and per-lesion sensitivity was 74.1% (43/58) and 81.1% (86/106), respectively. The sensitivity based on size <1cm, 1-2 cm, and >2 cm was 80.0% (28/35), 77.2% (44/57), and 100% (14/14).
  
  
  CONCLUSIONS
  MRI accurately detects HCC, including HCCs <2 cm. In our study population, the imaging disease staging was concordant with pathological staging in 80% of patients.
authors.affiliation: Columbia University, Dept. of Radiology, HP-3-305, NY, NY 10032, United States. Electronic address: rfh9001@nyp.org.
authors.forename: Robert F
authors.initials: RF
authors.lastname: Hanna
authors.affiliation: Icahn School of Medicine at Mount Sinai, One L. Gustave Levy Place, PO Box 1234, NY, NY 10029, United States. Electronic address: thomasjward@gmail.com.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Ward
authors.affiliation: Columbia University, Dept. of Radiology, HP-3-305, NY, NY 10032, United States. Electronic address: dsc2139@columbia.edu.
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Chow
authors.affiliation: Columbia University, Dept. of Pathology, Division of Liver Diseases, Vanderbilt Clinic, Mail Code: 14, NY, NY 10032, United States. Electronic address: sml2179@columbia.edu.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Lagana
authors.affiliation: Columbia University, Dept. of Pathology, Division of Liver Diseases, Vanderbilt Clinic, Mail Code: 14, NY, NY 10032, United States. Electronic address: roger_moreira@hotmail.com.
authors.forename: Roger K
authors.initials: RK
authors.lastname: Moreira
authors.affiliation: Columbia University, Dept. of Surgery, Liver Transplant, PH Room 14C, 622 West 168th St, New York, NY 10032, United States. Electronic address: je111@columbia.edu.
authors.forename: Jean C
authors.initials: JC
authors.lastname: Emond
authors.affiliation: Columbia University, Dept. of Radiology, HP-3-305, NY, NY 10032, United States. Electronic address: jw750@mail.cumc.columbia.edu.
authors.forename: Joshua L
authors.initials: JL
authors.lastname: Weintraub
authors.affiliation: Columbia University, Dept. of Radiology, HP-3-305, NY, NY 10032, United States. Electronic address: map2008@med.cornell.edu.
authors.forename: Martin R
authors.initials: MR
authors.lastname: Prince
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000209:etiology; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000209:etiology; D016031:Liver Transplantation; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods*; D012372:ROC Curve; D012016:Reference Values; D015203:Reproducibility of Results; D012189:Retrospective Studies; D055815:Young Adult
keywords: Biostatistics; Hepatocellular carcinoma; Liver transplantation; Magnetic resonance imaging