title: Effect of PDGF, IGF-1 and PRP on the implant osseointegration. An histological and immunohistochemical study in rabbits.
abstract: The ability of platelet-derived growth factor (PDGF), insulin-like growth factor-1 (IGF-1) and platelet-rich plasma (PRP) to increase the rate of osseointegration of endosseous implants and to improve the quality of bone remodeling on the surface of titanium, has been investigated in an experimental intraosseous defect model by an histological and immunohistochemical evaluation. The results from this study demonstrate that rabbits treated with the combination PDGF/IGF-1 showed a higher positive effect on bone regeneration than PRP-treated or controls.
authors.affiliation: General Dentistry and Emergency Care Unit George Eastman Dental Hospital, Rome, Italy.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Ortolani
authors.affiliation: Laboratory of Pathology, A. Cardarelli Hospital, Campobasso, Italy.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Guerriero
authors.affiliation: Institute of Pathology, Sacro Cuore Cattolica University, Rome, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Coli
authors.affiliation: Istituto Superiore di Sanita (ISS), Rome, Italy.
authors.forename: Amalia
authors.initials: A
authors.lastname: Di Giannuario
authors.affiliation: Private practice, Rome, Italy.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Minniti
authors.affiliation: Department of Oral and Maxillo-facial Sciences, Pediatric Dentistry Unit, Sapienza University of Rome, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Polimeni
keywords: IGF-1; PDGF; PRP; bone formation; dental implants; growth factors