title: Respiratory infection and primary immune deficiency - what does the general physician need to know?
abstract: This review, based on a talk given at the RCPE Respiratory Medicine Symposium 2014, outlines the clinical spectrum of immune deficiency - antibody (B cell) deficiency, T cell defects and innate/phagocytic disorders - and discusses the relevant clinical presentations, investigations and treatments, focusing particularly on the management of adults with recurrent respiratory infections. It describes when to suspect a primary immunodeficiency, the first-line investigations to perform and the triggers that should prompt referral for further specialist opinion. The paper concludes with a look at a novel primary immunodeficiency, Activated PI3 Kinase Delta Syndrome (APDS).
authors.affiliation: A Condliffe University of Cambridge Department of Medicine Addenbrooke's Hospital Hills Road Cambridge CB2 2QQ. Email amc46@medschl.cam.ac.uk.
authors.forename: S
authors.initials: S
authors.lastname: Lear
authors.forename: A
authors.initials: A
authors.lastname: Condliffe
mesh_terms: D000328:Adult; D000906:Antibodies / Q000097:blood; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D012141:Respiratory Tract Infections / Q000276:immunology*
chemical_list: D000906:Antibodies
keywords: Activated PI3 Kinase Delta Syndrome (APDS); antibody deficiency; common variable immunodeficiency; immunoglobulin; immunological screening; primary immunodeficiency