title: Genetics of osteoarthritis.
abstract: Osteoarthritis (OA) is a complex disease caused by the interaction of multiple genetic and environmental factors. This review focuses on the studies that have contributed to the discovery of genetic susceptibility factors in OA. The most relevant associations discovered until now are discussed in detail: GDF-5, 7q22 locus, MCF2L, DOT1L, NCOA3 and also some important findings from the arcOGEN study. Moreover, the different approaches that can be used to minimize the specific problems of the study of OA genetics are discussed. These include the study of microsatellites, phenotype standardization and other methods such as meta-analysis of GWAS and gene-based analysis. It is expected that these new approaches contribute to finding new susceptibility genetic factors for OA.
authors.affiliation: Laboratorio de Investigación 10, Rheumatology Unit, Instituto de Investigación Sanitaria Hospital Clínico Universitario de Santiago, Santiago de Compostela, La Coruña, España. Electronic address: mcrisrfon@gmail.com.
authors.forename: Cristina
authors.initials: C
authors.lastname: Rodriguez-Fontenla
authors.affiliation: Laboratorio de Investigación 10, Rheumatology Unit, Instituto de Investigación Sanitaria Hospital Clínico Universitario de Santiago, Santiago de Compostela, La Coruña, España.
authors.forename: Antonio
authors.initials: A
authors.lastname: Gonzalez
mesh_terms: D059647:Gene-Environment Interaction; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D010003:Osteoarthritis / Q000235:genetics*
chemical_list: D005819:Genetic Markers
keywords: Artrosis; Complex diseases; Enfermedades complejas; Estudios de asociación de genoma completo (GWAS); Genetics; Genome-wide association studies (GWAS); Genética; Osteoarthritis