title: Neuronal networks and energy bursts in epilepsy.
abstract: Epilepsy can be defined as the abnormal activities of neurons. The occurrence, propagation and termination of epileptic seizures rely on the networks of neuronal cells that are connected through both synaptic- and non-synaptic interactions. These complicated interactions contain the modified functions of normal neurons and glias as well as the mediation of excitatory and inhibitory mechanisms with feedback homeostasis. Numerous spread patterns are detected in disparate networks of ictal activities. The cortical-thalamic-cortical loop is present during a general spike wave seizure. The thalamic reticular nucleus (nRT) is the major inhibitory input traversing the region, and the dentate gyrus (DG) controls CA3 excitability. The imbalance between γ-aminobutyric acid (GABA)-ergic inhibition and glutamatergic excitation is the main disorder in epilepsy. Adjustable negative feedback that mediates both inhibitory and excitatory components affects neuronal networks through neurotransmission fluctuation, receptor and transmitter signaling, and through concomitant influences on ion concentrations and field effects. Within a limited dynamic range, neurons slowly adapt to input levels and have a high sensitivity to synaptic changes. The stability of the adapting network depends on the ratio of the adaptation rates of both the excitatory and inhibitory populations. Thus, therapeutic strategies with multiple effects on seizures are required for the treatment of epilepsy, and the therapeutic functions on networks are reviewed here. Based on the high-energy burst theory of epileptic activity, we propose a potential antiepileptic therapeutic strategy to transfer the high energy and extra electricity out of the foci.
authors.affiliation: The Neurology Department of Third Xiangya Hospital, Medical School of Central South University, Changsha, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Wu
authors.affiliation: The Neurology Department of Third Xiangya Hospital, Medical School of Central South University, Changsha, China.
authors.forename: D
authors.initials: D
authors.lastname: Liu
authors.affiliation: The Neurology Department of Third Xiangya Hospital, Medical School of Central South University, Changsha, China. Electronic address: docsong@126.com.
authors.forename: Z
authors.initials: Z
authors.lastname: Song
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use; D001921:Brain / Q000503:physiopathology*; D004827:Epilepsy / Q000209:etiology* / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D051379:Mice; D009415:Nerve Net / Q000503:physiopathology*; D009457:Neuroglia / Q000502:physiology; D009474:Neurons / Q000502:physiology; D017207:Rats, Sprague-Dawley; D013569:Synapses / Q000502:physiology
chemical_list: D000927:Anticonvulsants
keywords: GABAergic inhibition; antiepileptic; energy burst; epilepsy; glutamatergic excitation; networks