title: Solution NMR structures of immunoglobulin-like domains 7 and 12 from obscurin-like protein 1 contribute to the structural coverage of the Human Cancer Protein Interaction Network.
abstract: High-quality solution NMR structures of immunoglobulin-like domains 7 and 12 from human obscurin-like protein 1 were solved. The two domains share 30% sequence identity and their structures are, as expected, rather similar. The new structures contribute to structural coverage of human cancer associated proteins. Mutations of Arg 812 in domain 7 cause the rare 3-M syndrome, and this site is located in a surface area predicted to be involved in protein-protein interactions.
authors.affiliation: Department of Chemistry, The State University of New York at Buffalo and Northeast Structural Genomics Consortium, Buffalo, NY, 14260, USA.
authors.forename: Surya V S R K
authors.initials: SV
authors.lastname: Pulavarti
authors.forename: Yuanpeng J
authors.initials: YJ
authors.lastname: Huang
authors.forename: Kari
authors.initials: K
authors.lastname: Pederson
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Acton
authors.forename: Rong
authors.initials: R
authors.lastname: Xiao
authors.forename: John K
authors.initials: JK
authors.lastname: Everett
authors.forename: James H
authors.initials: JH
authors.lastname: Prestegard
authors.forename: Gaetano T
authors.initials: GT
authors.lastname: Montelione
authors.forename: Thomas
authors.initials: T
authors.lastname: Szyperski
mesh_terms: D003598:Cytoskeletal Proteins / Q000737:chemistry*; D006801:Humans; D009363:Neoplasm Proteins / Q000737:chemistry*; D009369:Neoplasms / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D017434:Protein Structure, Tertiary
chemical_list: D003598:Cytoskeletal Proteins; D009363:Neoplasm Proteins; C522000:OBSL1 protein, human