title: Quality of life in individuals living with HIV/AIDS attending a public sector antiretroviral service in Cape Town, South Africa.
abstract: BACKGROUND
  Health related quality of life (HRQoL) is an important outcome helping to understand the impact of antiretroviral therapy (ART). We examined and compared the HRQoL in relation to ART status among HIV-infected patients in a public sector service in Cape Town, South Africa. In addition, we aimed to examine the relationship between ART status and HRQoL according to CD4 count strata.
  
  
  METHODS
  A cross sectional study sample of 903 HIV-infected patients who were categorized as not receiving ART (ART-naïve) or receiving first-line ART for > 6 months (ART). HRQoL outcomes were compared in the two groups. HRQoL was assessed using the EQ-5D (five domains) and Visual Analogue Scale (EQ-5D VAS).
  
  
  RESULTS
  Of the total sample, 435 were categorised as ART naïve (76% women) and 468 were on ART (78% women). There were no significant associations between groups for most of the EQ-5D domains, however ART-naïve experienced a significantly greater problem with mobility than the ART group. Being ART-naïve (adjusted odds ratio (aOR) 3.08 95% confidence interval (CI) 1.63- 7.89) and obese 2.78 (95% CI 1.24- 6.22) were identified as predictors for increased mobility problems in multivariate analysis. In addition, receiving ART (5.61 difference; 95% CI 2.50 - 8.72) and having some source of income (4.76; 95% CI 1.63 -7.89) were identified as predictors for a higher EQ-5D VAS score. When grouped according to CD4 count strata, there were no significant difference between groups for most of the EQ-5D domains, however the ART-naïve group indicated having significantly greater problems under the CD4 count of >500 cells/μL in the anxiety/depression domain (22.4% vs 8.8%, p = 0.018) and significantly lower EQ-5D VAS scores under the CD4 counts of ≤ 200 cells/μL (median 80 (IQR 60-90) vs 90 (IQR 80-100), p = 0.0003) and 201-350 cells/μL (median 80 (IQR 70-90) vs 90 (80-100), p = 0.0004) compared to ART group.
  
  
  CONCLUSIONS
  HRQoL (self-rated health state) was improved with ART use, including those with immunocompromised status, which may be relevant to the public sector ART program in South Africa.
authors.affiliation: MRC/UCT Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa. mweete.nglazi@gmail.com.
authors.forename: Mweete D
authors.initials: MD
authors.lastname: Nglazi
authors.forename: Sacha J
authors.initials: SJ
authors.lastname: West
authors.forename: Joel A
authors.initials: JA
authors.lastname: Dave
authors.forename: Naomi S
authors.initials: NS
authors.lastname: Levitt
authors.forename: Estelle V
authors.initials: EV
authors.lastname: Lambert
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000188:drug therapy; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D001007:Anxiety / Q000209:etiology*; D018791:CD4 Lymphocyte Count; D003141:Communicable Diseases / Q000150:complications / Q000188:drug therapy; D003430:Cross-Sectional Studies; D003863:Depression / Q000209:etiology*; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007182:Income; D008297:Male; D051346:Mobility Limitation; D016017:Odds Ratio; D010146:Pain / Q000209:etiology*; D010147:Pain Measurement; D017150:Public Sector; D011788:Quality of Life; D013019:South Africa
chemical_list: D019380:Anti-HIV Agents