title: Acquired Von Willebrand syndrome secondary to mitral and aortic regurgitation.
abstract: The association between aortic stenosis and gastrointenstinal bleeding due to acquired von Willebrand syndrome (AVWS) has been well established. We report a patient with AVWS from underlying severe endocarditis-associated aortic regurgitation and pre-existing mitral regurgitation. Cardiovascular disease-related AVWS occurs from a selective loss of the largest multimers of von Willebrand factor from high shear forces, and desmopressin leads to transient clinical improvement.
authors.affiliation: Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA. Electronic address: wan.siuhin@mayo.edu.
authors.forename: Siu-Hin
authors.initials: SH
authors.lastname: Wan
authors.affiliation: Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Jackson J
authors.initials: JJ
authors.lastname: Liang
authors.affiliation: Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Rakhee
authors.initials: R
authors.lastname: Vaidya
authors.affiliation: Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Blackshear
authors.affiliation: Division of Hematopathology, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Dong
authors.initials: D
authors.lastname: Chen
mesh_terms: D001022:Aortic Valve Insufficiency / Q000150:complications* / Q000209:etiology; D004696:Endocarditis / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000150:complications*; D014842:von Willebrand Diseases / Q000209:etiology*