title: Protective effects of Borago officinalis extract on amyloid β-peptide(25-35)-induced memory impairment in male rats: a behavioral study.
abstract: Alzheimer's disease (AD) is a neurodegenerative disorder and most common form of dementia that leads to memory impairment. In the present study we have examined the protective effects of Borago officinalis (borage) extract on Amyloid β (A β)-Induced memory impairment. Wistar male rats received intrahippocampal (IHP) injection of the A β (25-35) and borage extract throughout gestation (100 mg/kg). Learning and memory functions in the rats were examined by the passive avoidance and the Morris water maze (MWM) tasks. Finally, the antioxidant capacity of hippocampus was measured using ferric ion reducing antioxidant power (FRAP) assay. The results showed that A β (25-35) impaired step-through latency and time in dark compartment in passive avoidance task. In the MWM, A β (25-35) significantly increased escape latency and traveled distance. Borage administration attenuated the A β-induced memory impairment in both the passive avoidance and the MWM tasks. A β induced a remarkable decrease in antioxidant power (FRAP value) of hippocampus and borage prevented the decrease of the hippocampal antioxidant status. This data suggests that borage could improve the learning impairment and oxidative damage in the hippocampal tissue following A β treatment and that borage consumption may lead to an improvement of AD-induced cognitive dysfunction.
authors.affiliation: Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan 65178-3-8736, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Ghahremanitamadon
authors.affiliation: Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan 65178-3-8736, Iran.
authors.forename: Siamak
authors.initials: S
authors.lastname: Shahidi
authors.affiliation: Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan 65178-3-8736, Iran.
authors.forename: Somayeh
authors.initials: S
authors.lastname: Zargooshnia
authors.affiliation: Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan 65178-3-8736, Iran ; Student Research Committee, Hamadan University of Medical Sciences, Hamadan 65178-3-8736, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Nikkhah
authors.affiliation: Department of Toxicology and Pharmacology, School of Medicine, Hamadan University of Medical Sciences, Hamadan 65178-3-8736, Iran.
authors.forename: Akram
authors.initials: A
authors.lastname: Ranjbar
authors.affiliation: Anatomy Department, School of Medicine, Hamadan University of Medical Sciences, Hamadan 65178-3-8736, Iran.
authors.forename: Sara
authors.initials: S
authors.lastname: Soleimani Asl
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000008:administration & dosage*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D029683:Borago / Q000737:chemistry; D003072:Cognition Disorders / Q000188:drug therapy; D004195:Disease Models, Animal; D006624:Hippocampus / Q000187:drug effects; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000188:drug therapy* / Q000473:pathology; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry; D051381:Rats
chemical_list: D016229:Amyloid beta-Peptides; D010936:Plant Extracts