title: Predictive factors for natural pregnancy after microsurgical reconstruction in patients with primary epididymal obstructive azoospermia.
abstract: Primary epididymal obstructive azoospermia (OA) is the most prevalent form of OA in nonvasectomized patients and has been less studied. We aim to assess the results with microsurgical vasoepididymostomy used in the treatment of men diagnosed with primary epididymal obstructive azoospermia and to identify the factors associated with natural pregnancy occurring after microsurgical reconstruction. This prospective study included consecutive patients with epididymal OA who underwent microsurgical reconstruction in our center. Clinical and biological data were obtained every three months during follow-up. Occurrence of natural pregnancy was the primary study outcome. In total, 36 patients underwent microsurgical reconstruction. The mean age was 34 ± 4.5 years (range 24-46 years). Median follow-up time was 15 [IQR 12-21] months. The total patency rate was 77.7% (n = 28). During follow-up, 8 (22.2%) natural pregnancies occurred. The overall live birth rate was 100%. Low FSH levels (HR: 0.22; 95% CI: 0.052-0.88; P = 0.032) and higher total motile sperm count (TMSC) (HR: 1.001; 95% CI 1-1.001; P = 0.012) were associated with a higher rate of natural pregnancy. Our data suggest that microsurgical vasoepididymostomy is an effective therapy of primary epididymal OA. Baseline lower FSH and higher TMSC were independent predictors for natural pregnancy occurrence.
authors.affiliation: Center for Uronephrology and Renal Transplantation, Fundeni Clinical Institute, 258 Fundeni Street, District 2, 022328 Bucharest, Romania.
authors.forename: Mihai
authors.initials: M
authors.lastname: Harza
authors.affiliation: Center for Uronephrology and Renal Transplantation, Fundeni Clinical Institute, 258 Fundeni Street, District 2, 022328 Bucharest, Romania.
authors.forename: Sebastian
authors.identifier: 0000-0002-8096-5237
authors.initials: S
authors.lastname: Voinea
authors.affiliation: Center of Internal Medicine-Nephrology, Fundeni Clinical Institute, 022328 Bucharest, Romania.
authors.forename: Gener
authors.identifier: 0000-0003-3306-189X
authors.initials: G
authors.lastname: Ismail
authors.affiliation: Center for Uronephrology and Renal Transplantation, Fundeni Clinical Institute, 258 Fundeni Street, District 2, 022328 Bucharest, Romania.
authors.forename: Cristian
authors.initials: C
authors.lastname: Gagiu
authors.affiliation: Center for Uronephrology and Renal Transplantation, Fundeni Clinical Institute, 258 Fundeni Street, District 2, 022328 Bucharest, Romania.
authors.forename: Catalin
authors.initials: C
authors.lastname: Baston
authors.affiliation: Center for Uronephrology and Renal Transplantation, Fundeni Clinical Institute, 258 Fundeni Street, District 2, 022328 Bucharest, Romania.
authors.forename: Adrian
authors.initials: A
authors.lastname: Preda
authors.affiliation: Center for Uronephrology and Renal Transplantation, Fundeni Clinical Institute, 258 Fundeni Street, District 2, 022328 Bucharest, Romania.
authors.forename: Ioan
authors.initials: I
authors.lastname: Manea
authors.affiliation: Center for Uronephrology and Renal Transplantation, Fundeni Clinical Institute, 258 Fundeni Street, District 2, 022328 Bucharest, Romania.
authors.forename: Tiberiu
authors.initials: T
authors.lastname: Priporeanu
authors.affiliation: Center for Uronephrology and Renal Transplantation, Fundeni Clinical Institute, 258 Fundeni Street, District 2, 022328 Bucharest, Romania.
authors.forename: Ioanel
authors.identifier: 0000-0002-3162-1366
authors.initials: I
authors.lastname: Sinescu