title: Response to thrombolytic agents in acute myocardial infarction in opium abusers versus non-abusers.
abstract: OBJECTIVE
  Coronary artery disease is one of the leading causes of morbidity and mortality in populations. In opium abusers, level of circulating coagulation factors differs from non-abusers. The aim of this study was to evaluate response to thrombolytic therapy in opium abusers vs. non-abusers.
  
  
  METHODS
  In this prospective observational study, 83 patients (36 opium abusers and 47 non-abusers) with AMI were evaluated for the presence and degree of response to thrombolytic agent. All patients were monitored for electrocardiographic changes and response to thrombolysis 2 hours before and after administration of thrombolytic agent. Serum CPK and LDH were measured 2 hours before and after thrombolysis. Quantitative and qualitative data were analyzed by independent t-test and chi-square using SPSS, respectively.
  
  
  RESULTS
  ST-resolution 2 hours after thrombolysis was 63.8% and 44.4% in opium users and non-users, respectively. Serum level of CPK cardiac biomarker 2 hours after thrombolysis was 980 ± 245 and 847 ± 130 IU/L in opium users and non-users, respectively.
  
  
  CONCLUSIONS
  Our data demonstrate that in those patients with opium abuse, electrocardiographic changes after thrombolysis were significantly lower than opium non-users (P < 0.05). Opium users showed better ST-resolution compared with non-users. Opium addiction had effect on cardiac enzymes despite their effect on response to streptokinase.
authors.affiliation: Department of Cardiology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Seyed Mohammad Hashemi
authors.initials: SM
authors.lastname: Jazi
authors.affiliation: Department of Cardiology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Idin Ahang
authors.initials: IA
authors.lastname: Nazary
authors.affiliation: Department of Cardiology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Mohaddeseh
authors.initials: M
authors.lastname: Behjati
keywords: Acute myocardial infarction; ST-resolution; opium addiction; thrombolysis