title: Colon capsule endoscopy is a safe and useful tool to assess disease parameters in patients with ulcerative colitis.
abstract: OBJECTIVE
  Colon capsule endoscopy (CCE) is a new endoscopic technique that is minimally invasive and allows evaluation of the colon mucosa without pain, sedation, and gas insufflation. To date, few studies have investigated the use of CCE in patients with ulcerative colitis (UC). This study compares the ability of CCE and a conventional colonoscopy to assess mucosal disease activity and the extent of inflammatory mucosa in patients with UC.
  
  
  METHODS
  Forty-two patients (27 men, mean age 48.5 years) with known UC and indication for colonoscopy were enrolled in this single-blind, prospective study. All patients underwent CCE, followed by a colonoscopy. The activity and extent of the disease was assessed using Mayo scores and Montreal scores, respectively.
  
  
  RESULTS
  There was a good correlation between CCE and colonoscopy in disease severity (κ=0.79; 95% confidence interval: 0.62-0.96) and extent of inflammation (κ=0.71; 95% confidence interval: 0.52-0.90) observed. The ability of CCE to assess a broad segment of distal ileum led to a change in the diagnosis of UC to ileocolonic Crohn's disease in three patients. Bowel preparation was considered adequate in 80% of the patients and no serious adverse events related to the CCE procedure or bowel preparation were reported.
  
  
  CONCLUSIONS
  CCE is a safe and useful method for the evaluation of patients with UC. The ability of CCE to assess distal ileum provides an advantage to colonoscopy as CCE can identify patients who have been incorrectly diagnosed with UC, resulting in a change in their diagnosis to Crohn's disease.
authors.affiliation: Virgen Macarena Hospital, Sevilla, Spain.
authors.forename: Mileidis
authors.initials: M
authors.lastname: San Juan-Acosta
authors.forename: Angel
authors.initials: A
authors.lastname: Caunedo-Álvarez
authors.forename: Federico
authors.initials: F
authors.lastname: Argüelles-Arias
authors.forename: Luisa
authors.initials: L
authors.lastname: Castro-Laria
authors.forename: Blas
authors.initials: B
authors.lastname: Gómez-Rodríguez
authors.forename: Javier
authors.initials: J
authors.lastname: Romero-Vázquez
authors.forename: Alba
authors.initials: A
authors.lastname: Belda-Cuesta
authors.forename: Francisco
authors.initials: F
authors.lastname: Pellicer-Bautista
authors.forename: Juan M
authors.initials: JM
authors.lastname: Herrerías-Gutiérrez
mesh_terms: D000328:Adult; D000368:Aged; D053704:Capsule Endoscopy / Q000009:adverse effects / Q000379:methods*; D002400:Cathartics; D003093:Colitis, Ulcerative / Q000175:diagnosis*; D003113:Colonoscopy / Q000009:adverse effects / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D016037:Single-Blind Method; D055815:Young Adult
chemical_list: D002400:Cathartics