title: Anthocyanins from Eugenia brasiliensis edible fruits as potential therapeutics for COPD treatment.
abstract: Nine anthocyanins (1-9) from the edible fruits of Eugenia brasiliensis were identified by HPLC-PDA and LC-MS, and seven of these are described for the first time in this Brazilian fruit. Two of the major anthocyanins, delphinidin (8) and cyanidin (9), were studied for their inhibitory activity against chemokine interleukin-8 (IL-8) production before and after cigarette smoke extract (CSE) treatment of cells. In non-treated cells the amount of IL-8 was unchanged following treatment with cyanidin and delphinidin in concentrations 0.1-10 μM. Both delphinidin (8) and cyanidin (9) decreased the production of IL-8 in treated cells, at 1 and 10 μM, respectively. Delphinidin (8) demonstrated IL-8 inhibition in the CSE treated cells in a dose-dependent manner.
authors.affiliation: Department of Biological Sciences, Lehman College and The Graduate Center, City University of New York, 250 Bedford Park Boulevard West, Bronx, NY 10468, United States; Instituto de Fermentaciones Industriales, Consejo Superior de Investigaciones Científicas (CSIC), c/Juan de la Cierva 3, 28006 Madrid, Spain.
authors.forename: Gema
authors.initials: G
authors.lastname: Flores
authors.affiliation: Department of Biological Sciences, Lehman College and The Graduate Center, City University of New York, 250 Bedford Park Boulevard West, Bronx, NY 10468, United States.
authors.forename: Keyvan
authors.initials: K
authors.lastname: Dastmalchi
authors.affiliation: Department of Biological Sciences, Lehman College and The Graduate Center, City University of New York, 250 Bedford Park Boulevard West, Bronx, NY 10468, United States.
authors.forename: Sturlainny
authors.initials: S
authors.lastname: Paulino
authors.affiliation: Department of Biological Sciences, Lehman College and The Graduate Center, City University of New York, 250 Bedford Park Boulevard West, Bronx, NY 10468, United States; Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 W 168th Street, P&S 9-449, New York, NY 10032, United States.
authors.forename: Kathleen
authors.initials: K
authors.lastname: Whalen
authors.affiliation: Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 W 168th Street, P&S 9-449, New York, NY 10032, United States.
authors.forename: Abdoulaye J
authors.initials: AJ
authors.lastname: Dabo
authors.affiliation: Department of Biological Sciences, Lehman College and The Graduate Center, City University of New York, 250 Bedford Park Boulevard West, Bronx, NY 10468, United States.
authors.forename: Kurt A
authors.initials: KA
authors.lastname: Reynertson
authors.affiliation: Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 W 168th Street, P&S 9-449, New York, NY 10032, United States.
authors.forename: Robert F
authors.initials: RF
authors.lastname: Foronjy
authors.affiliation: Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 W 168th Street, P&S 9-449, New York, NY 10032, United States.
authors.forename: Jeanine M
authors.initials: JM
authors.lastname: D'Armiento
authors.affiliation: Department of Biological Sciences, Lehman College and The Graduate Center, City University of New York, 250 Bedford Park Boulevard West, Bronx, NY 10468, United States.
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Kennelly
mesh_terms: D000872:Anthocyanins / Q000494:pharmacology*; D001938:Brazil; D002478:Cells, Cultured; D002851:Chromatography, High Pressure Liquid; D004847:Epithelial Cells / Q000187:drug effects / Q000378:metabolism; D000068856:Eugenia / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry*; D006801:Humans; D016209:Interleukin-8 / Q000378:metabolism*; D013058:Mass Spectrometry; D010936:Plant Extracts / Q000494:pharmacology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy*; D012137:Respiratory System / Q000187:drug effects / Q000378:metabolism; D012906:Smoke / Q000009:adverse effects
chemical_list: D000872:Anthocyanins; D016209:Interleukin-8; D010936:Plant Extracts; D012906:Smoke