title: Cutaneous adverse reactions to lenalidomide.
abstract: Lenalidomide is an immunomodulatory drug (IMiD) used principally in the treatment of multiple myeloma (MM), myelodysplastic syndromes (MS) and amyloidosis. Adverse reactions related to lenalidomide include myelosuppression (mainly neutropenia but also thrombocytopenia), gastrointestinal problems, skin eruption, atrial fibrillation and asthenia, decreased peripheral blood stem cell yield during stem cell collection, venous thromboembolism, and secondary malignances. In this review we focused our attention on the cutaneous adverse reactions to lenalidomide.
authors.affiliation: Department of Clinical and Experimental Medicine, School and Unit of Allergy and Clinical Immunology, University of Messina, Italy. Electronic address: sele19pf@gmail.com.
authors.forename: S
authors.initials: S
authors.lastname: Imbesi
authors.affiliation: Division of Hematology, University of Messina, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Allegra
authors.affiliation: Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, University of Messina, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Calapai
authors.affiliation: Division of Hematology, University of Messina, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Musolino
authors.affiliation: Department of Clinical and Experimental Medicine, School and Unit of Allergy and Clinical Immunology, University of Messina, Italy; Institute of Biomedicine and Molecular Immunology "A. Monroy" (IBIM) - Consiglio Nazionale delle Ricerche (CNR), Palermo, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Gangemi
mesh_terms: D000686:Amyloidosis / Q000150:complications / Q000188:drug therapy*; D000818:Animals; D003875:Drug Eruptions / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D000077269:Lenalidomide; D009101:Multiple Myeloma / Q000150:complications / Q000188:drug therapy*; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000188:drug therapy*; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D013792:Thalidomide / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D013792:Thalidomide; D000077269:Lenalidomide
keywords: Adverse cutaneous reactions; Amyloidosis; Erythema multiforme; Immunomodulatory drugs; Lenalidomide; Multiple myeloma; Myelodisplastic syndromes; Stevens–Johnson syndrome; Toxic epidermal necrolysis