title: Sialochemical analysis: a portal for the oral diagnostician.
abstract: BACKGROUND
  Depressive disorders, worldwide, may rank second by the year 2020. In India; about 10 million people suffer from depressive disorders, the prevalence rate being recorded as 31.2 for every 1000 individuals. A significant impairment of all personal hygiene may occur due to a depressive episode which in turn may result in altered biochemical composition of some important salivary parameters. The present study was done to assess the relationship and bring about a comparison of certain selective sialochemical alterations between normal and subjects with depressive disorders.
  
  
  METHODS
  The present study was a hospital- based clinical cross-sectional study which was conducted in Bhopal, the heart of Madhya Pradesh, India. The survey period extended over a period of one year and two months, from May 2009 to July 2010.
  
  
  METHODS
  Unstimulated whole saliva was analysed biochemically for α- amylase, calcium, sodium, potassium, total proteins and urea. The data obtained in this study were statistically analyzed by using Unpaired Student's t-test.
  
  
  RESULTS
  Salivary calcium and total protein levels were found to be statistically significant among all three groups (p< 0.0001). Salivary amylase levels between Groups II and III and between Groups I and III (p< 0.0001) was statistically significant while the salivary urea levels between Groups I and Group II and between Groups I and III were found to be statistically significant (p< 0.0001). However, there was no statistical difference in their sodium and potassium levels.
  
  
  CONCLUSIONS
  It was observed that drugs do affect the salivary composition. It was observed that cyclic antidepressants produced significant alteration in the sialochemical constituents of saliva as compared to TCAs and TeCAs.
authors.affiliation: Assistant Professor, Department of Oral Medicine and Radiology, People's College of Dental Sciences and Research Centre , Bhopal, Madhya Pradesh, India .
authors.forename: Annette B
authors.initials: AB
authors.lastname: Milton
authors.affiliation: Professor, Department of Oral Medicine and Radiology, People's College of Dental Sciences and Research Centre , Bhopal, Madhya Pradesh, India .
authors.forename: Ajay
authors.initials: A
authors.lastname: Bhambal
keywords: Depression; Sialochemistry; Unstimulated saliva