title: [Role of pretherapeutic biomarkers in lung cancer with special regards to bronchoscopic procedures].
abstract: Molecular biomarkers are becoming increasingly significant in the workup of lung carcinoma patients. They assist in diagnosis, selecting the most adequate therapy and determining prognosis. Obtaining blood based biomarkers or volatile markers in exhaled breath may provide a less invasive method in the future. For the time being, bronchoscopy is still the method of choice to obtain specimen and assess tissue based biomarkers. The techniques how specimen are collected and processed for analysis are of paramount importance.
authors.affiliation: Abteilung für interventionelle Pneumologie, Ruhrlandklinik, Westdeutsches Lungenzentrum am Universitätsklinikum Essen.
authors.forename: K
authors.initials: K
authors.lastname: Darwiche
authors.affiliation: Abteilung für interventionelle Pneumologie, Ruhrlandklinik, Westdeutsches Lungenzentrum am Universitätsklinikum Essen.
authors.forename: F
authors.initials: F
authors.lastname: Özkan
authors.affiliation: Institut für Pathologie, Universitätsklinikum Essen.
authors.forename: S
authors.initials: S
authors.lastname: Ting
authors.affiliation: Institut für Prävention und Arbeitsmedizin der Deutschen Gesetzlichen Unfallversicherung (IPA), Institut der Ruhr-Universität Bochum.
authors.forename: G
authors.initials: G
authors.lastname: Johnen
authors.affiliation: Institut für Prävention und Arbeitsmedizin der Deutschen Gesetzlichen Unfallversicherung (IPA), Institut der Ruhr-Universität Bochum.
authors.forename: T
authors.initials: T
authors.lastname: Brüning
authors.affiliation: Institut für klinische Pathologie, UniversitätsSpital Zürich, Schweiz.
authors.forename: A
authors.initials: A
authors.lastname: Soltermann
authors.affiliation: Klinik für Pneumologie, UniversitätsSpital Zürich, Schweiz.
authors.forename: L C
authors.initials: LC
authors.lastname: Huber
authors.affiliation: Innere Klinik (Tumorforschung), Westdeutsches Tumorzentrum Essen, Universitätsklinikum Essen.
authors.forename: D C
authors.initials: DC
authors.lastname: Christoph
authors.affiliation: Abteilung für interventionelle Pneumologie, Ruhrlandklinik, Westdeutsches Lungenzentrum am Universitätsklinikum Essen.
authors.forename: L
authors.initials: L
authors.lastname: Freitag
authors.affiliation: Klinik für Pneumologie, UniversitätsSpital Zürich, Schweiz.
authors.forename: D
authors.initials: D
authors.lastname: Franzen
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D001980:Bronchi / Q000378:metabolism*; D001999:Bronchoscopy / Q000379:methods*; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000378:metabolism* / Q000628:therapy; D009363:Neoplasm Proteins / Q000378:metabolism*; D011300:Preoperative Care / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins