title: Synthesis and pharmacological evaluation of modified adenosines joined to mono-functional platinum moieties.
abstract: The synthesis of four novel platinum complexes, bearing N6-(6-amino-hexyl)adenosine or a 1,6-di(adenosin-N6-yl)-hexane respectively, as ligands of mono-functional cisplatin or monochloro(ethylendiamine)platinum(II), is reported. The chemistry exploits the high affinity of the charged platinum centres towards the N7 position of the adenosine base system and a primary amine of an alkyl chain installed on the C6 position of the purine. The cytotoxic behaviour of the synthesized complexes has been studied in A549 adenocarcinomic human alveolar basal epithelial and MCF7 human breast adenocarcinomic cancer cell lines, in order to investigate their effects on cell viability and proliferation.
authors.affiliation: Dipartimento di Farmacia, Università degli Studi di Napoli "Federico II", via D. Montesano, 49, 80131 Napoli, Italy. stefano.derrico@unina.it.
authors.forename: Stefano
authors.initials: S
authors.lastname: D'Errico
authors.affiliation: Dipartimento di Farmacia, Università degli Studi di Napoli "Federico II", via D. Montesano, 49, 80131 Napoli, Italy. golivier@unina.it.
authors.forename: Giorgia
authors.initials: G
authors.lastname: Oliviero
authors.affiliation: Dipartimento di Farmacia, Università degli Studi di Napoli "Federico II", via D. Montesano, 49, 80131 Napoli, Italy. borbone@unina.it.
authors.forename: Nicola
authors.initials: N
authors.lastname: Borbone
authors.affiliation: Dipartimento di Scienze Chimiche, Università degli Studi di Napoli "Federico II", via Cintia, 21, 80126 Napoli, Italy. vinpicci@unina.it.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Piccialli
authors.affiliation: Dipartimento di Farmacia, Università degli Studi di Napoli "Federico II", via D. Montesano, 49, 80131 Napoli, Italy. brunella.pinto87@gmail.com.
authors.forename: Brunella
authors.initials: B
authors.lastname: Pinto
authors.affiliation: Dipartimento di Farmacia, Università degli Studi di Napoli "Federico II", via D. Montesano, 49, 80131 Napoli, Italy. francesca.defalco@unina.it.
authors.forename: Francesca
authors.initials: F
authors.lastname: De Falco
authors.affiliation: Dipartimento di Farmacia, Università degli Studi di Napoli "Federico II", via D. Montesano, 49, 80131 Napoli, Italy. mariachiara.maiuri@unina.it.
authors.forename: Maria Chiara
authors.initials: MC
authors.lastname: Maiuri
authors.affiliation: Dipartimento di Farmacia, Università degli Studi di Napoli "Federico II", via D. Montesano, 49, 80131 Napoli, Italy. rosa.carnuccio@unina.it.
authors.forename: Rosa
authors.initials: R
authors.lastname: Carnuccio
authors.affiliation: Dipartimento di Farmacia, Università degli Studi di Napoli "Federico II", via D. Montesano, 49, 80131 Napoli, Italy. valeria.costantino@unina.it.
authors.forename: Valeria
authors.initials: V
authors.lastname: Costantino
authors.affiliation: Dipartimento di Farmacia, Università degli Studi di Napoli "Federico II", via D. Montesano, 49, 80131 Napoli, Italy. fabrizia.nici@unina.it.
authors.forename: Fabrizia
authors.initials: F
authors.lastname: Nici
authors.affiliation: Dipartimento di Farmacia, Università degli Studi di Napoli "Federico II", via D. Montesano, 49, 80131 Napoli, Italy. picciall@unina.it.
authors.forename: Gennaro
authors.initials: G
authors.lastname: Piccialli
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D000075202:Contraindications; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D061986:MCF-7 Cells; D017671:Platinum Compounds / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D017671:Platinum Compounds; D000241:Adenosine