title: C-Met expression pattern in uterine leiomyoma.
abstract: OBJECTIVE
  Growth factors take place in the formation and growth of uterine leiomyomas (LMs). Transforming growth factor beta (TGF-beta), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), fibroblast growth factor-2 (FGF-2), and insulin-like growth factor (IGF) contribute to the pathophysiology of LMs when they bind with a specific membrane receptor and transmit a signal into the cell. Little is known about hepatocyte growth factor (HGF) and its receptor system c-Met in formation and growth of uterine LMs. The aim of this study was to evaluate the c-Met receptor expression on human myometrium and uterine LMs.
  
  
  METHODS
  The study was performed on human myometrium and uterine LMs. Expression of c-Met receptor was evaluated by immunohistochemical analysis.
  
  
  RESULTS
  Overexpression of c-Met was found in all LM cases and in none of normal myometrium samples c-Met overexpression was seen.
  
  
  CONCLUSIONS
  HGF and c-Met receptor complex seem to have role in development of uterine LMs.
authors.forename: F K
authors.initials: FK
authors.lastname: Boynukalin
authors.forename: C
authors.initials: C
authors.lastname: Comunoglu
authors.forename: I
authors.initials: I
authors.lastname: Türkmen
authors.forename: G M
authors.initials: GM
authors.lastname: Kuzey
authors.forename: O T
authors.initials: OT
authors.lastname: Güler
authors.forename: C
authors.initials: C
authors.lastname: Baykal
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000737:chemistry*; D008875:Middle Aged; D009215:Myometrium / Q000737:chemistry*; D019859:Proto-Oncogene Proteins c-met / Q000032:analysis*; D014594:Uterine Neoplasms / Q000737:chemistry*
chemical_list: D019859:Proto-Oncogene Proteins c-met