title: The predictive value of platelet function point-of-care tests for postoperative blood loss and transfusion in routine cardiac surgery: a systematic review.
abstract: Excessive bleeding after cardiopulmonary bypass (CPB) operations remains to be a persistent problem and weak platelet function certainly contributes to bleeding diathesis. Antiplatelet therapy (APT) is an integral component of perioperative management in patients undergoing cardiac surgery procedures, both with and without use of CPB. In addition to individual variability in platelet function, different preoperative APT administration/discontinuation management further affects platelet function, which in turn may reflect bleeding tendency. However, the impact of drug-induced platelet inhibition on early postoperative bleeding extent remains difficult to predict. Herein, we reviewed the available evidence on the association between platelet function testing values and the extent of bleeding and transfusion requirements in early perioperative period. Currently, the association between platelet function measured by ex vivo assay and the occurrence of bleeding events remains uncertain. The intent of this review is to provide comprehensive literature insight into published evidence, investigating the possibility of platelet function tests to predict bleeding extent as well as transfusion requirements in cardiac surgery patients.
authors.affiliation: Department of Cardiac Surgery, University of Zagreb School of Medicine-University Hospital Center Zagreb, Zagreb, Croatia.
authors.forename: Mate
authors.initials: M
authors.lastname: Petricevic
authors.affiliation: Department of Cardiac Surgery, University of Zagreb School of Medicine-University Hospital Center Zagreb, Zagreb, Croatia.
authors.forename: Tomislav
authors.initials: T
authors.lastname: Kopjar
authors.affiliation: Department of Cardiac Surgery, University of Zagreb School of Medicine-University Hospital Center Zagreb, Zagreb, Croatia.
authors.forename: Bojan
authors.initials: B
authors.lastname: Biocina
authors.affiliation: Department of Cardiovascular Diseases, University of Zagreb School of Medicine-University Hospital Center Zagreb, Zagreb, Croatia.
authors.forename: Davor
authors.initials: D
authors.lastname: Milicic
authors.affiliation: Department of Medical Diagnostics, University of Split School of Medicine-University Hospital Center Split, Split, Croatia.
authors.forename: Kresimir
authors.initials: K
authors.lastname: Kolic
authors.affiliation: Department of Cardiology, University Hospital "Thalassotherapia Opatija," Medical School University of Rijeka and Osijek, Opatija, Croatia.
authors.forename: Marko
authors.initials: M
authors.lastname: Boban
authors.affiliation: Department of Cardiovascular Diseases, University of Zagreb School of Medicine-University Hospital Center Zagreb, Zagreb, Croatia.
authors.forename: Bosko
authors.initials: B
authors.lastname: Skoric
authors.affiliation: Department of Cardiac Surgery, University of Zagreb School of Medicine-University Hospital Center Zagreb, Zagreb, Croatia.
authors.forename: Ante
authors.initials: A
authors.lastname: Lekic
authors.affiliation: Department of Cardiac Surgery, University of Zagreb School of Medicine-University Hospital Center Zagreb, Zagreb, Croatia.
authors.forename: Hrvoje
authors.initials: H
authors.lastname: Gasparovic
mesh_terms: D001803:Blood Transfusion; D006348:Cardiac Surgical Procedures; D001026:Coronary Artery Bypass; D005544:Forecasting; D006801:Humans; D008991:Monitoring, Physiologic; D059035:Perioperative Period; D010979:Platelet Function Tests; D019095:Point-of-Care Systems; D019106:Postoperative Hemorrhage / Q000175:diagnosis* / Q000628:therapy*