title: Effect of long term vitamin D supplementation on biomarkers of inflammation in Latino and African-American subjects with pre-diabetes and hypovitaminosis D.
abstract: Low vitamin D levels are associated with minority subjects, the metabolic syndrome, and inflammation. The effect of vitamin D supplementation on markers of inflammation has not been well studied. The aim of the study was to evaluate the effects of high doses of vitamin D supplementation for 1 year on serum biomarkers of inflammation in Latino and African-American subjects with pre-diabetes and hypovitaminosis D. Latino (n=69) and African-American (n=11) subjects who had both pre-diabetes and hypovitaminosis D with a mean age of 52.0 years, a BMI of 32.7 kg/m(2), and 70% of whom were females, were randomized to receive weekly doses (mean±SD) of vitamin D (85 300 IU±16 000) or placebo oil for 1 year. Serum levels of interleukin-6, tumor necrosis factor, highly sensitive C-reactive protein), plasminogen activator inhibitor 1, and insulin-like growth factor-1 were measured at baseline, 6, and 12 months. Serum 25-OH vitamin D levels of 22 ng/ml at baseline quickly rose to nearly 70 ng/ml in subjects receiving vitamin D and did not change in the placebo group. Two-way repeated measures ANOVA showed no differences between the 2 groups in any of the 5 selected parameters. High dose vitamin D supplementation for 1 year in minority subjects with pre-diabetes and hypovitaminosis D failed to affect serum biomarkers of inflammation.Clinical trial reg. no.: NCT00876928, clinicaltrials.gov.
authors.affiliation: Department of Internal Medicine, Division of Endocrinology, Charles R. Drew University of Medicine and Science, Los Angeles, CA, USA.
authors.forename: I
authors.initials: I
authors.lastname: Sinha-Hikim
authors.affiliation: Department of Internal Medicine, Division of Endocrinology, Charles R. Drew University of Medicine and Science, Los Angeles, CA, USA.
authors.forename: P
authors.initials: P
authors.lastname: Duran
authors.affiliation: Department of Internal Medicine, Division of Endocrinology, Charles R. Drew University of Medicine and Science, Los Angeles, CA, USA.
authors.forename: R
authors.initials: R
authors.lastname: Shen
authors.affiliation: Department of Internal Medicine, Division of Endocrinology, Charles R. Drew University of Medicine and Science, Los Angeles, CA, USA.
authors.forename: M
authors.initials: M
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Division of Endocrinology, Charles R. Drew University of Medicine and Science, Los Angeles, CA, USA.
authors.forename: T C
authors.initials: TC
authors.lastname: Friedman
authors.affiliation: Department of Internal Medicine, Division of Endocrinology, Charles R. Drew University of Medicine and Science, Los Angeles, CA, USA.
authors.forename: M B
authors.initials: MB
authors.lastname: Davidson
mesh_terms: D000328:Adult; D001741:Black or African American; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D019587:Dietary Supplements; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D007249:Inflammation / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D010919:Placebos; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D011236:Prediabetic State / Q000097:blood*; D014807:Vitamin D / Q000008:administration & dosage* / Q000031:analogs & derivatives / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood*
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D010919:Placebos; D017395:Plasminogen Activator Inhibitor 1; D014807:Vitamin D; D007334:Insulin-Like Growth Factor I; D002097:C-Reactive Protein; C104450:25-hydroxyvitamin D