title: Voxel-based correlation between whole-brain CT perfusion with 320-row area detector ct and iodine 123 iodoamphetamine brain perfusion spect in patients with cerebrovascular disease.
abstract: OBJECTIVE
  We compared cerebral blood flow (CBF) measured using computed tomographic (CT) perfusion (CTP) and N-isopropyl-p-[(123) I]-iodoamphetamine cerebral perfusion single-photon emission computed tomography (SPECT).
  
  
  METHODS
  We used a 320-row area detector CT and N-isopropyl-p-[(123) I]-iodoamphetamine cerebral perfusion SPECT under similar conditions in patients with chronic cerebrovascular disease. Images were automatically aligned 3-dimensionally for voxel-by-voxel comparisons.
  
  
  RESULTS
  Linear positive correlations were observed between CTP-CBF including high-blood-flow areas and SPECT-CBF over the whole brain (r = 0.001-0.6, P < 0.01), superior cerebral level (r = 0.45-0.93, P < 0.01), basal ganglia level (r = 0.44-0.77, P < 0.01), and skull base (r = 0.02-0.66, P < 0.01). Correlations between CTP-CBF excluding high-blood-flow areas were significantly higher (P < 0.0001).
  
  
  CONCLUSIONS
  Computed tomographic perfusion overestimated CBF compared with SPECT and showed poor correlation at the skull base. Computed tomographic perfusion CTP excluding high-blood-flow areas improved the correlation over the whole brain in patients with chronic cerebrovascular disease.
authors.affiliation: From the *Department of Radiology and †Neurosurgery, Fujita Health University, Toyoake, Japan; ‡Division of Nuclear Medicine, Graduate School of Medicine, University of Tokyo, Japan; Software Development Group, Product Management and Marketing Department., Sales and Marketing Division, FUJIFILM RI Pharma Co., Ltd., Japan; §Clinical Application Research Center, Toshiba Medical Systems Corporation, Otawara, Japan; and ∥Joint Research Laboratory of Advanced Medical Imaging, Fujita Health University, Toyoake, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Murayama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Toyama
authors.forename: Motoharu
authors.initials: M
authors.lastname: Hayakawa
authors.forename: Shuei
authors.initials: S
authors.lastname: Imizu
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Soma
authors.forename: Akira
authors.initials: A
authors.lastname: Taniguchi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Katada
mesh_terms: D000328:Adult; D000368:Aged; D000662:Amphetamines; D001783:Blood Flow Velocity; D002533:Cerebral Angiography / Q000379:methods*; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000175:diagnosis* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D014057:Tomography, X-Ray Computed / Q000379:methods*; D055815:Young Adult
chemical_list: D000662:Amphetamines; D019275:Radiopharmaceuticals; C041336:4-iodoamphetamine