title: Different tumor necrosis factor α antagonists have different effects on host susceptibility to disseminated and oropharyngeal candidiasis in mice.
abstract: Tumor necrosis factor α is important for the host defense against intracellular pathogens. We tested the effect of mouse analogs of human TNF-α antagonists, the rat anti-mouse TNF-α monoclonal antibody (XT22) and the soluble mouse 75 kDa TNF-α receptor fused to the Fc portion of mouse IgG1 (p75-Fc), on the susceptibility of mice to hematogenously disseminated candidiasis (HDC) and oropharyngeal candidiasis (OPC). Both XT22 and p75-Fc significantly reduced mice survival, increased kidney fungal burden, and reduced leukocyte recruitment during HDC. However, only XT22 significantly increased the oral fungal burden and reduced leukocyte recruitment during OPC. This result suggests that XT22 and p75-Fc affect host susceptibility to different types of Candida albicans infections by different inhibitory mechanisms.
authors.affiliation: California State University Los Angeles; Los Angeles, CA USA.
authors.forename: Hyunsook
authors.initials: H
authors.lastname: Park
authors.affiliation: Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center; Torrance, CA USA.
authors.forename: Norma V
authors.initials: NV
authors.lastname: Solis
authors.affiliation: David Geffen School of Medicine at University of California at Los Angeles; Los Angeles, CA USA.
authors.forename: James S
authors.initials: JS
authors.lastname: Louie
authors.affiliation: Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center; Torrance, CA USA; David Geffen School of Medicine at University of California at Los Angeles; Los Angeles, CA USA.
authors.forename: Brad
authors.initials: B
authors.lastname: Spellberg
authors.affiliation: California State University Los Angeles; Los Angeles, CA USA.
authors.forename: Natalie
authors.initials: N
authors.lastname: Rodriguez
authors.affiliation: Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center; Torrance, CA USA; David Geffen School of Medicine at University of California at Los Angeles; Los Angeles, CA USA.
authors.forename: Scott G
authors.initials: SG
authors.lastname: Filler
mesh_terms: D000818:Animals; D002176:Candida albicans / Q000254:growth & development* / Q000276:immunology / Q000302:isolation & purification; D058387:Candidemia / Q000139:chemically induced / Q000276:immunology*; D002180:Candidiasis, Oral / Q000139:chemically induced / Q000276:immunology*; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007962:Leukocytes / Q000276:immunology; D008297:Male; D008807:Mice, Inbred BALB C; D016019:Survival Analysis; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000276:immunology
chemical_list: D007166:Immunosuppressive Agents; D014409:Tumor Necrosis Factor-alpha
keywords: Candida albicans; hematogenously disseminated candidiasis; host susceptibility; murine model; oropharyngeal candidiasis; tumor necrosis factor antagonists