title: Helicobacter pylori: perspectives and time trends.
abstract: The discovery of Helicobacter pylori three decades ago is a modern medical success story. It markedly changed our understanding of the pathophysiology of gastroduodenal diseases and led to an improvement in the treatment of diseases related to H. pylori infection. Many of these diseases (such as ulcer disease and mucosal associated lymphoid tissue lymphoma) have become curable, and others (gastric cancer) might be preventable with the application of H. pylori eradication therapy. Since its discovery, H. pylori has also been identified as a trigger for some extragastric diseases. Promising results in this exciting field might have a clinical effect in the near future. This Timeline gives an overview of the success of clinical research on H. pylori to date and highlights some future trends in this area.
authors.affiliation: Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital, Leipziger Strasse 44, D-39120 Magdeburg, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Malfertheiner
authors.affiliation: Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital, Leipziger Strasse 44, D-39120 Magdeburg, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Link
authors.affiliation: Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital, Leipziger Strasse 44, D-39120 Magdeburg, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Selgrad
mesh_terms: D035843:Biomedical Research / Q000639:trends; D005756:Gastritis / Q000209:etiology* / Q000382:microbiology; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000209:etiology* / Q000382:microbiology; D010437:Peptic Ulcer / Q000209:etiology* / Q000382:microbiology; D013274:Stomach Neoplasms / Q000209:etiology* / Q000382:microbiology