title: Laparoscopic antireflux surgery in patients with extra esophageal symptoms related to asthma.
abstract: BACKGROUND
  Asthma, laryngitis and chronic cough are atypical symptoms of the gastroesophageal reflux disease.
  
  
  OBJECTIVE
  To analyze the efficacy of laparoscopic surgery in the remission of extra-esophageal symptoms in patients with gastroesophageal reflux, related to asthma.
  
  
  METHODS
  Were reviewed the medical records of 400 patients with gastroesophageal reflux disease submitted to laparoscopic Nissen fundoplication from 1994 to 2006, and identified 30 patients with extra-esophageal symptoms related to asthma. The variables considered were: gender, age, gastroesophageal symptoms (heartburn, acid reflux and dysphagia), time of reflux disease, treatment with proton pump inhibitor, use of specific medications, treatment and evolution, number of attacks and degree of esophagitis. Data were subjected to statistical analysis, comparing the pre- and post-surgical findings.
  
  
  RESULTS
  The comparative analysis before surgery (T1) and six months after surgery (T2) showed a significant reduction on heartburn and reflux symptoms. Apart from that, there was a significant difference between the patients with daily crises of asthma (T1 versus T2, 45.83% to 16.67%, p=0.0002) and continuous crises (T1, 41.67% versus T2, 8.33%, p=0.0002).
  
  
  CONCLUSIONS
  Laparoscopic Nissen fundoplication was effective in improving symptoms that are typical of reflux disease and clinical manifestations of asthma.
authors.affiliation: Departamento de Cirurgia e Gastrocentro, Faculdade de Ciências Médicas, Universidade Estadual de Campinas.
authors.forename: Amanda Pinter Carvalheiro da
authors.initials: AP
authors.lastname: Silva
authors.affiliation: Departamento de Cirurgia e Gastrocentro, Faculdade de Ciências Médicas, Universidade Estadual de Campinas.
authors.forename: Valdir
authors.initials: V
authors.lastname: Tercioti-Junior
authors.affiliation: Departamento de Cirurgia e Gastrocentro, Faculdade de Ciências Médicas, Universidade Estadual de Campinas.
authors.forename: Luiz Roberto
authors.initials: LR
authors.lastname: Lopes
authors.affiliation: Departamento de Cirurgia e Gastrocentro, Faculdade de Ciências Médicas, Universidade Estadual de Campinas.
authors.forename: João de Souza
authors.initials: Jde S
authors.lastname: Coelho-Neto
authors.affiliation: Departamento de Cirurgia e Gastrocentro, Faculdade de Ciências Médicas, Universidade Estadual de Campinas.
authors.forename: Laura
authors.initials: L
authors.lastname: Bertanha
authors.affiliation: Departamento de Cirurgia e Gastrocentro, Faculdade de Ciências Médicas, Universidade Estadual de Campinas.
authors.forename: Paulo Rodrigo de Faria
authors.initials: PR
authors.lastname: Rodrigues
authors.affiliation: Departamento de Cirurgia e Gastrocentro, Faculdade de Ciências Médicas, Universidade Estadual de Campinas.
authors.forename: Nelson Adami
authors.initials: NA
authors.lastname: Andreollo
mesh_terms: D001249:Asthma / Q000209:etiology*; D018662:Fundoplication / Q000379:methods; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000601:surgery*; D006801:Humans; D010535:Laparoscopy