title: Correlation of inhibin and several antioxidants in children with acute lymphoblastic leukemia.
abstract: BACKGROUND
  Acute lymphoblastic leukemia (ALL) is most common in childhood. Inhibin (a non-steroidal glycoprotein hormone of gonadal origin) can be used as marker of fertility. The current study was conducted to evaluate inhibin levels in ALL patients and to estimate its correlation with some antioxidants in these in comparison with control subjects.
  
  
  METHODS
  This study was conducted on sixty patients with ALL and thirty children as controls. Fasting blood samples were taken from each subject and analyzed for haemoglobin, serum protein, vitamin E and C, in addition to glutathione and inhibin.
  
  
  RESULTS
  The results of the study showed highly significant decreases (p<0.001) in haemoglobin, glutathione and inhibin levels with significant decreases (p<0.05) in serum protein and vitamin E levels for patients group in comparison with controls while there was no significant differences in vitamin C. Moreover, there were significant correlations between inhibin levels and serum protein, glutathione and both vitamins (E and C) in the ALL patient group (r= 0.81, 0.80, 0.77 and 0.69, respectively).
  
  
  CONCLUSIONS
  The present results indicated infertility in patients with ALL demonstrated by low inhibin level as a consequence of abnormality in anti-oxidative metabolism due to the cancer process. So, it can be suggested the need for routine measurement of inhibin for leukemic patients to estimate the action of hormones of gonadal origin.
authors.affiliation: Department of Acceptable Analysis, Health and Medical Technical College, university of Baghdad, Baghdad, Iraq E-mail : waadmwa@yahoo.com.
authors.forename: Atheer Awad
authors.initials: AA
authors.lastname: Mehde
authors.forename: Wesen Adel
authors.initials: WA
authors.lastname: Mehdi
authors.forename: Jwan Abdulmohsin
authors.initials: JA
authors.lastname: Zainulabdeen
authors.forename: Alaa Shawqi
authors.initials: AS
authors.lastname: Abdulbari
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007246:Infertility / Q000097:blood / Q000175:diagnosis*; D007265:Inhibins / Q000097:blood*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood* / Q000150:complications / Q000473:pathology; D011379:Prognosis
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D007265:Inhibins