title: EGFR inhibitors may induce tumor stemness.
abstract: EGFR inhibitors spur tumor cells to express CD61 and become more stem cell-like. A combination treatment that includes bortezomib might reverse these changes.
mesh_terms: D001897:Boronic Acids / Q000494:pharmacology*; D000069286:Bortezomib; D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D066246:ErbB Receptors / Q000037:antagonists & inhibitors; D000069347:Erlotinib Hydrochloride; D006801:Humans; D039661:Integrin beta3 / Q000378:metabolism; D014411:Neoplastic Stem Cells / Q000187:drug effects* / Q000378:metabolism; D011719:Pyrazines / Q000494:pharmacology*; D011799:Quinazolines / Q000494:pharmacology*
chemical_list: D001897:Boronic Acids; C061248:ITGB3 protein, human; D039661:Integrin beta3; D011719:Pyrazines; D011799:Quinazolines; D000069286:Bortezomib; D000069347:Erlotinib Hydrochloride; D066246:ErbB Receptors