title: Caloric restriction impedes age-related decline of mitochondrial function and neuronal activity.
abstract: Caloric restriction (CR) prolongs lifespan and retards many detrimental effects of aging, but its effect on brain mitochondrial function and neuronal activity--especially in healthy aging--remains unexplored. Here we measured rates of neuronal glucose oxidation and glutamate-glutamine neurotransmitter cycling in young control, old control (i.e., healthy aging), and old CR rats using in vivo nuclear magnetic resonance spectroscopy. We found that, compared with the young control, neuronal energy production and neurotransmission rates were significantly reduced in healthy aging, but were preserved in old CR rats. The results suggest that CR mitigated the age-related deceleration of brain physiology.
authors.affiliation: 1] Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA [2] Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA.
authors.forename: Ai-Ling
authors.initials: AL
authors.lastname: Lin
authors.affiliation: 1] Magnetic Resonance Research Center, Yale University, New Haven, Connecticut, USA [2] Quantitative Neuroscience with Magnetic Resonance Core Center, Yale University, New Haven, Connecticut, USA [3] Department of Diagnostic Radiology, Yale University, New Haven, Connecticut, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Coman
authors.affiliation: 1] Magnetic Resonance Research Center, Yale University, New Haven, Connecticut, USA [2] Quantitative Neuroscience with Magnetic Resonance Core Center, Yale University, New Haven, Connecticut, USA [3] Department of Diagnostic Radiology, Yale University, New Haven, Connecticut, USA.
authors.forename: Lihong
authors.initials: L
authors.lastname: Jiang
authors.affiliation: 1] Magnetic Resonance Research Center, Yale University, New Haven, Connecticut, USA [2] Quantitative Neuroscience with Magnetic Resonance Core Center, Yale University, New Haven, Connecticut, USA [3] Department of Diagnostic Radiology, Yale University, New Haven, Connecticut, USA [4] Department of Biomedical Engineering, Yale University, New Haven, Connecticut, USA.
authors.forename: Douglas L
authors.initials: DL
authors.lastname: Rothman
authors.affiliation: 1] Magnetic Resonance Research Center, Yale University, New Haven, Connecticut, USA [2] Quantitative Neuroscience with Magnetic Resonance Core Center, Yale University, New Haven, Connecticut, USA [3] Department of Diagnostic Radiology, Yale University, New Haven, Connecticut, USA [4] Department of Biomedical Engineering, Yale University, New Haven, Connecticut, USA.
authors.forename: Fahmeed
authors.initials: F
authors.lastname: Hyder
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D031204:Caloric Restriction; D018698:Glutamic Acid / Q000378:metabolism*; D005973:Glutamine / Q000378:metabolism*; D008297:Male; D008928:Mitochondria / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D005973:Glutamine; D018698:Glutamic Acid