title: Nanodevices for studying nano-pathophysiology.
abstract: Nano-scaled devices are a promising platform for specific detection of pathological targets, facilitating the analysis of biological tissues in real-time, while improving the diagnostic approaches and the efficacy of therapies. Herein, we review nanodevice approaches, including liposomes, nanoparticles and polymeric nanoassemblies, such as polymeric micelles and vesicles, which can precisely control their structure and functions for specifically interacting with cells and tissues. These systems have been successfully used for the selective delivery of reporter and therapeutic agents to specific tissues with controlled cellular and subcellular targeting of biomolecules and programmed operation inside the body, suggesting a high potential for developing the analysis for nano-pathophysiology.
authors.affiliation: Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. Electronic address: horacio@bmw.t.u-tokyo.ac.jp.
authors.forename: Horacio
authors.initials: H
authors.lastname: Cabral
authors.affiliation: Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Kanjiro
authors.initials: K
authors.lastname: Miyata
authors.affiliation: Center for Molecular Systems, Kyushu University, 744 Moto-oka, Nishi-ku, Fukuoka, 819-0395, Japan; Department of Applied Chemistry, Faculty of Engineering, Kyushu University, 744 Moto-oka, Nishi-ku, Fukuoka, 819-0395, Japan. Electronic address: kishimura@mail.cstm.kyushu-u.ac.jp.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Kishimura
mesh_terms: D000818:Animals; D006801:Humans; D008024:Ligands; D008055:Lipids / Q000737:chemistry; D008823:Micelles; D049329:Nanostructures / Q000737:chemistry / Q000627:therapeutic use; D011108:Polymers / Q000737:chemistry
chemical_list: D008024:Ligands; D008055:Lipids; D008823:Micelles; D011108:Polymers
keywords: Nanomaterials; Polymeric self-assemblies; Theranostic nano-devices