title: A modular designed copolymer with anti-thrombotic activity and imaging capability.
abstract: Through a modular ROMP (ring-opening metathesis polymerization) strategy, a random copolymer with anti-thrombotic activity and imaging capability has been constructed from RGD, rhodamine B and PEG modified norbornene monomers. As we expected, these tri-component polynorbornenes exhibit significant enhancement in anti-thrombotic efficacy and bioavailability in vivo.
authors.affiliation: School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, P. R. China. mingzhao@bjmu.edu.cn sqpeng@bjmu.edu.cn.
authors.forename: Nan
authors.initials: N
authors.lastname: Xie
authors.forename: Ke
authors.initials: K
authors.lastname: Feng
authors.forename: Bin
authors.initials: B
authors.lastname: Chen
authors.forename: Ming
authors.initials: M
authors.lastname: Zhao
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Zhang
authors.forename: Chen-Ho
authors.initials: CH
authors.lastname: Tung
authors.forename: Li-Zhu
authors.initials: LZ
authors.lastname: Wu
authors.forename: Shiqi
authors.initials: S
authors.lastname: Peng
mesh_terms: D015195:Drug Design; D005343:Fibrinolytic Agents / Q000737:chemistry* / Q000494:pharmacology*; D057054:Molecular Imaging / Q000379:methods*; D009842:Oligopeptides / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D058105:Polymerization; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology*; D012235:Rhodamines / Q000737:chemistry
chemical_list: D005343:Fibrinolytic Agents; D009842:Oligopeptides; D011108:Polymers; D012235:Rhodamines; D011092:Polyethylene Glycols; C047981:arginyl-glycyl-aspartic acid; C029773:rhodamine B