title: Dynamic disorder and the energetic costs of information transduction.
abstract: We study a model of dynamic disorder relevant for signal transduction pathways in which enzymatic reaction rates fluctuate over several orders of magnitude. For the simple networks we consider, dynamic disorder drives the system far from equilibrium and imposes an energetic burden for high fidelity signaling capability. We study how the dynamics of the underlying stochastic behavior in the reaction rate process is related to the energetic cost of transmitting information through the network.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Thill
mesh_terms: D003198:Computer Simulation; D004735:Energy Transfer; D019277:Entropy; D004798:Enzymes / Q000737:chemistry*; D031541:Fluorescence Resonance Energy Transfer; D008962:Models, Theoretical
chemical_list: D004798:Enzymes