title: Endoscopic full-thickness resection and laparoscopic surgery for treatment of gastric stromal tumors.
abstract: OBJECTIVE
  To assess the effectiveness of endoscopic full-thickness resection (EFR) and laparoscopic surgery in the treatment of gastric stromal tumors arising from the muscularis propria.
  
  
  METHODS
  Out of 62 gastric stromal tumors arising from the muscularis propria, each > 1.5 cm in diameter, 32 were removed by EFR, and 30 were removed by laparoscopic surgery. The tumor expression of CD34, CD117, Dog-1, S-100, and SMA was assessed immunohistochemically. The operative time, complete resection rate, length of hospital stay, incidence of complications, and recurrence rate were compared between the two groups. Continuous data were compared using independent samples t-tests, and categorical data were compared using χ (2) tests.
  
  
  RESULTS
  The 32 gastric stromal tumors treated by EFR and the 30 treated by laparoscopic surgery showed similar operative time [20-155 min (mean, 78.5 ± 30.1 min) vs 50-120 min (mean, 80.9 ± 46.7 min), P > 0.05], complete resection rate (100% vs 93.3%, P > 0.05), and length of hospital stay [4-10 d (mean, 5.9 ± 1.4 d) vs 4-19 d (mean, 8.9 ± 3.2 d), P >0.05]. None of the patients treated by EFR experienced complications, whereas two patients treated by laparoscopy required a conversion to laparotomy, and one patient had postoperative gastroparesis. No recurrences were observed in either group. Immunohistochemical staining showed that of the 62 gastric stromal tumors diagnosed by gastroscopy and endoscopic ultrasound, six were leiomyomas (SMA-positive), one was a schwannoglioma (S-100 positive), and the remaining 55 were stromal tumors.
  
  
  CONCLUSIONS
  Some gastric stromal tumors arising from the muscularis propria can be completely removed by EFR. EFR could likely replace surgical or laparoscopic procedures for the removal of gastric stromal tumors.
authors.affiliation: Liu-Ye Huang, Jun Cui, Cheng-Rong Wu, Bo Zhang, Li-Xin Jiang, Xiang-Shu Xian, Shu-Juan Lin, Ning Xu, Xiao-Ling Cao, Zhi-Hua Wang, Department of Gastroenterology, Yantai Yu Huang Ding Hospital, Yantai 264000, Shandong Province, China.
authors.forename: Liu-Ye
authors.initials: LY
authors.lastname: Huang
authors.affiliation: Liu-Ye Huang, Jun Cui, Cheng-Rong Wu, Bo Zhang, Li-Xin Jiang, Xiang-Shu Xian, Shu-Juan Lin, Ning Xu, Xiao-Ling Cao, Zhi-Hua Wang, Department of Gastroenterology, Yantai Yu Huang Ding Hospital, Yantai 264000, Shandong Province, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Cui
authors.affiliation: Liu-Ye Huang, Jun Cui, Cheng-Rong Wu, Bo Zhang, Li-Xin Jiang, Xiang-Shu Xian, Shu-Juan Lin, Ning Xu, Xiao-Ling Cao, Zhi-Hua Wang, Department of Gastroenterology, Yantai Yu Huang Ding Hospital, Yantai 264000, Shandong Province, China.
authors.forename: Cheng-Rong
authors.initials: CR
authors.lastname: Wu
authors.affiliation: Liu-Ye Huang, Jun Cui, Cheng-Rong Wu, Bo Zhang, Li-Xin Jiang, Xiang-Shu Xian, Shu-Juan Lin, Ning Xu, Xiao-Ling Cao, Zhi-Hua Wang, Department of Gastroenterology, Yantai Yu Huang Ding Hospital, Yantai 264000, Shandong Province, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Liu-Ye Huang, Jun Cui, Cheng-Rong Wu, Bo Zhang, Li-Xin Jiang, Xiang-Shu Xian, Shu-Juan Lin, Ning Xu, Xiao-Ling Cao, Zhi-Hua Wang, Department of Gastroenterology, Yantai Yu Huang Ding Hospital, Yantai 264000, Shandong Province, China.
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Jiang
authors.affiliation: Liu-Ye Huang, Jun Cui, Cheng-Rong Wu, Bo Zhang, Li-Xin Jiang, Xiang-Shu Xian, Shu-Juan Lin, Ning Xu, Xiao-Ling Cao, Zhi-Hua Wang, Department of Gastroenterology, Yantai Yu Huang Ding Hospital, Yantai 264000, Shandong Province, China.
authors.forename: Xiang-Shu
authors.initials: XS
authors.lastname: Xian
authors.affiliation: Liu-Ye Huang, Jun Cui, Cheng-Rong Wu, Bo Zhang, Li-Xin Jiang, Xiang-Shu Xian, Shu-Juan Lin, Ning Xu, Xiao-Ling Cao, Zhi-Hua Wang, Department of Gastroenterology, Yantai Yu Huang Ding Hospital, Yantai 264000, Shandong Province, China.
authors.forename: Shu-Juan
authors.initials: SJ
authors.lastname: Lin
authors.affiliation: Liu-Ye Huang, Jun Cui, Cheng-Rong Wu, Bo Zhang, Li-Xin Jiang, Xiang-Shu Xian, Shu-Juan Lin, Ning Xu, Xiao-Ling Cao, Zhi-Hua Wang, Department of Gastroenterology, Yantai Yu Huang Ding Hospital, Yantai 264000, Shandong Province, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Xu
authors.affiliation: Liu-Ye Huang, Jun Cui, Cheng-Rong Wu, Bo Zhang, Li-Xin Jiang, Xiang-Shu Xian, Shu-Juan Lin, Ning Xu, Xiao-Ling Cao, Zhi-Hua Wang, Department of Gastroenterology, Yantai Yu Huang Ding Hospital, Yantai 264000, Shandong Province, China.
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Cao
authors.affiliation: Liu-Ye Huang, Jun Cui, Cheng-Rong Wu, Bo Zhang, Li-Xin Jiang, Xiang-Shu Xian, Shu-Juan Lin, Ning Xu, Xiao-Ling Cao, Zhi-Hua Wang, Department of Gastroenterology, Yantai Yu Huang Ding Hospital, Yantai 264000, Shandong Province, China.
authors.forename: Zhi-Hua
authors.initials: ZH
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D016009:Chi-Square Distribution; D002681:China; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects / Q000379:methods*; D046152:Gastrointestinal Stromal Tumors / Q000737:chemistry / Q000473:pathology / Q000601:surgery*; D005773:Gastroscopy / Q000009:adverse effects; D006801:Humans; D007150:Immunohistochemistry; D010535:Laparoscopy / Q000009:adverse effects; D007889:Leiomyoma / Q000737:chemistry / Q000473:pathology / Q000601:surgery*; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009442:Neurilemmoma / Q000737:chemistry / Q000473:pathology / Q000601:surgery*; D061646:Operative Time; D011183:Postoperative Complications / Q000628:therapy; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000737:chemistry / Q000473:pathology / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor
keywords: Endoscopy; Full-thickness resection; Gastric stromal tumors; Muscularis propria; Treatment