title: Iron-catalyzed intermolecular hydroamination of styrenes.
abstract: An iron-catalyzed formal hydroamination of alkenes has been developed. It features O-benzoyl-N,N-dialkylhydroxylamines as the electrophilic nitrogen source and cyclopentylmagnesium bromide as the reducing agent for intermolecular hydroamination of styrene and derivatives with good yield and excellent Markovnikov regioselectivity. The reaction presumably proceeds through the iron-catalyzed hydrometalation of styrene followed by electrophilic amination with the electrophilic O-benzoylhydroxylamine.
authors.affiliation: Department of Chemistry, Texas A&M University , College Station, Texas 77843-3255, United States.
authors.forename: C Bryan
authors.initials: CB
authors.lastname: Huehls
authors.forename: Aijun
authors.initials: A
authors.lastname: Lin
authors.forename: Jiong
authors.initials: J
authors.lastname: Yang
mesh_terms: D000475:Alkenes / Q000737:chemistry; D000586:Amination; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D006898:Hydroxylamines / Q000737:chemistry*; D007501:Iron / Q000737:chemistry*; D015394:Molecular Structure; D020058:Styrene / Q000737:chemistry*
chemical_list: D000475:Alkenes; D006898:Hydroxylamines; D020058:Styrene; C010046:O-benzoylhydroxylamine; D007501:Iron