title: 4-Hydroxychalcone attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice.
abstract: In the present study, we aimed to investigate the preventive effects of 4-hydroxychalcone (4HCH) on resistant hypertension. We used cryptochrome-null mice, which characteristically show high plasma aldosterone levels, inflammation, and renal injury. The cryptochrome-null mice received high-salt treatment and were treated orally with 4HCH 10 mg/kg, 4HCH 20 mg/kg, and 4HCH 40 mg/kg, respectively. The salt administration in cryptochrome-null mice is able to induce an increase in systolic pressure which is associated with hyperaldosteronism, inflammation, and kidney injury. Treatment with 40 mg/kg 4HCH reduced systolic hypertension, serum IL-1β, and TNF-α levels and suppressed the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and renal injury. The impact of 4HCH on the hyperaldosteronism, inflammation, and kidney injury provides new insights for future development of therapeutic strategies in resistant hypertension.
authors.affiliation: Department of Cardiovascular Surgery, The Fourth People's Hospital of Jinan City, Jinan 250031, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Qu
authors.affiliation: Department of Cardiovascular Surgery, The Fourth People's Hospital of Jinan City, Jinan 250031, China.
authors.forename: Bingguang
authors.initials: B
authors.lastname: Dai
authors.affiliation: Department of Cardiovascular Surgery, The Fourth People's Hospital of Jinan City, Jinan 250031, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.affiliation: Department of Cardiovascular Surgery, The Fourth People's Hospital of Jinan City, Jinan 250031, China.
authors.forename: Xuelian
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Cardiovascular Surgery, Qilu Children's Hospital of Shandong University, Jinan 250031, China.
authors.forename: Yimin
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Cardiovascular Surgery, The Fourth People's Hospital of Jinan City, Jinan 250031, China.
authors.forename: Fuling
authors.initials: F
authors.lastname: Zhang
mesh_terms: D000450:Aldosterone / Q000097:blood; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D047188:Chalcones / Q000494:pharmacology / Q000627:therapeutic use*; D056931:Cryptochromes / Q000172:deficiency* / Q000378:metabolism; D006929:Hyperaldosteronism / Q000097:blood / Q000150:complications* / Q000188:drug therapy* / Q000503:physiopathology; D007249:Inflammation / Q000150:complications* / Q000188:drug therapy*; D053583:Interleukin-1beta / Q000097:blood; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D018345:Mice, Knockout; D016328:NF-kappa B / Q000378:metabolism; D013599:Systole / Q000187:drug effects; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D047188:Chalcones; D056931:Cryptochromes; D053583:Interleukin-1beta; D016328:NF-kappa B; D014409:Tumor Necrosis Factor-alpha; C451019:4-hydroxychalcone; D000450:Aldosterone