title: The association between ischaemia-modified albumin levels in umbilical vein and intrauterine growth restriction.
abstract: Intrauterine growth restriction (IUGR) is one of the most common problems in obstetrics. Ischaemia-modified albumin (IMA), a product deriving from albumin as a result of the modification by oxidative free radicals in response to hypoxia, was previously used as a marker of ischaemia in acute coronary syndrome. We performed this study to determine whether umbilical venous IMA levels are associated with IUGR. A total of 40 pregnancies with IUGR were compared with 40 of normal fetal development. Blood samples were obtained from the umbilical vein after delivery. IMA levels in the IUGR group were higher than in the control group (78.74 ± 6.87 vs 74.43 ± 7.84 U/ml, respectively, p = 0.011). An elevated IMA level was associated with IUGR (OR: 1.079, 95% CI: 1.000-1.163, p = 0.049). We suggest that IMA, which was formerly proved to arise in ischaemic conditions, may also be a valuable marker in perinatal hypoxia and IUGR detection.
authors.affiliation: Department of Obstetrics and Gynecology, Akdeniz University , Antalya , Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Karadeniz
authors.forename: I
authors.initials: I
authors.lastname: Mendilcioglu
authors.forename: S
authors.initials: S
authors.lastname: Ozdem
authors.forename: M
authors.initials: M
authors.lastname: Ozekinci
authors.forename: C Y
authors.initials: CY
authors.lastname: Sanhal
authors.forename: G
authors.initials: G
authors.lastname: Uzun
authors.forename: M
authors.initials: M
authors.lastname: Sakinci
authors.forename: M
authors.initials: M
authors.lastname: Simsek
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005240:Feasibility Studies; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood*; D006801:Humans; D011247:Pregnancy; D012709:Serum Albumin; D000075462:Serum Albumin, Human; D014471:Umbilical Veins; D055815:Young Adult
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; C561522:ischemia-modified albumin; D000075462:Serum Albumin, Human
keywords: Asphyxia; IUGR; diagnosis; intrauterine; pH; umbilical cord