title: Multiple sclerosis patients lacking oligoclonal bands in the cerebrospinal fluid have less global and regional brain atrophy.
abstract: To investigate whether multiple sclerosis (MS) patients with and without cerebrospinal fluid (CSF) oligoclonal immunoglobulin G bands (OCB) differ in brain atrophy. Twenty-eight OCB-negative and thirty-five OCB-positive patients were included. Larger volumes of total CSF and white matter (WM) lesions; smaller gray matter (GM) volume in the basal ganglia, diencephalon, cerebellum, and hippocampus; and smaller WM volume in corpus callosum, periventricular-deep WM, brainstem, and cerebellum, were observed in OCB-positives. OCB-negative patients, known to differ genetically from OCB-positives, are characterized by less global and regional brain atrophy. This finding supports the notion that OCB-negative MS patients may represent a clinically relevant MS subgroup.
authors.affiliation: Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics (Karolinska Institutet), Novum 5th floor, 141 86 Stockholm, Sweden. Electronic address: daniel.ferreira.padilla@ki.se.
authors.forename: Daniel
authors.initials: D
authors.lastname: Ferreira
authors.affiliation: Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics (Karolinska Institutet), Novum 5th floor, 141 86 Stockholm, Sweden.
authors.forename: Olga
authors.initials: O
authors.lastname: Voevodskaya
authors.affiliation: Department of Clinical Neuroscience (Karolinska Institutet), Center for Molecular Medicine (CMM), L8:00, 171 76, Stockholm, Sweden.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Imrell
authors.affiliation: Department of Clinical Neuroscience (Karolinska Institutet), Center for Molecular Medicine (CMM), L8:00, 171 76, Stockholm, Sweden.
authors.forename: Leszek
authors.initials: L
authors.lastname: Stawiarz
authors.affiliation: Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics (Karolinska Institutet), Novum 5th floor, 141 86 Stockholm, Sweden.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Spulber
authors.affiliation: Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics (Karolinska Institutet), Novum 5th floor, 141 86 Stockholm, Sweden.
authors.forename: Lars-Olof
authors.initials: LO
authors.lastname: Wahlund
authors.affiliation: Department of Clinical Neuroscience (Karolinska Institutet), Center for Molecular Medicine (CMM), L8:00, 171 76, Stockholm, Sweden.
authors.forename: Jan
authors.initials: J
authors.lastname: Hillert
authors.affiliation: Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics (Karolinska Institutet), Novum 5th floor, 141 86 Stockholm, Sweden.
authors.forename: Eric
authors.initials: E
authors.lastname: Westman
authors.affiliation: Department of Clinical Neuroscience (Karolinska Institutet), Center for Molecular Medicine (CMM), L8:00, 171 76, Stockholm, Sweden.
authors.forename: Virginija Danylaité
authors.initials: VD
authors.lastname: Karrenbauer
mesh_terms: D000328:Adult; D001284:Atrophy / Q000134:cerebrospinal fluid / Q000276:immunology / Q000473:pathology; D001921:Brain / Q000276:immunology / Q000473:pathology; D001927:Brain Diseases / Q000134:cerebrospinal fluid / Q000276:immunology* / Q000473:pathology; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000134:cerebrospinal fluid / Q000276:immunology* / Q000473:pathology; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000134:cerebrospinal fluid / Q000276:immunology* / Q000473:pathology; D015999:Multivariate Analysis; D043025:Oligoclonal Bands / Q000134:cerebrospinal fluid / Q000276:immunology*
chemical_list: D043025:Oligoclonal Bands
keywords: Brain atrophy; Cerebrospinal fluid; MRI; Multiple Esclerosis; Multivariate analyses; Oligoclonal bands