title: Regulatory B cells in experimental mouse models of arthritis.
abstract: Regulatory B cells (Bregs) have been shown to play a role in the suppression of a wide variety of immune responses. For the study of autoimmune inflammation, experimental models of arthritis have acted as a valuable tool in understanding the function of Bregs in maintaining immune homeostasis. In this chapter, we will focus on the study of transitional-2 marginal zone precursor Bregs (T2-MZPs) in the context of two experimental arthritis models: antigen-induced arthritis (AIA) and collagen-induced arthritis (CIA). We will specifically focus on how to induce arthritis as well as methods for the isolation and functional study of Bregs both in vitro and in vivo.
authors.affiliation: Centre for Rheumatology, Division of Medicine, University College London, 5 University Street, London, WC1E 6JF, UK.
authors.forename: Elizabeth C
authors.initials: EC
authors.lastname: Rosser
authors.forename: Claudia
authors.initials: C
authors.lastname: Mauri
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D000941:Antigens; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000276:immunology* / Q000473:pathology; D060151:B-Lymphocytes, Regulatory / Q000276:immunology* / Q000473:pathology*; D003094:Collagen; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D051379:Mice / Q000276:immunology*
chemical_list: D000941:Antigens; D003094:Collagen