title: Preparation and biodistribution of a (99m)Tc tricarbonyl complex with deoxyglucose dithiocarbamate as a tumor imaging agent for SPECT.
abstract: The deoxyglucose dithiocarbamate (DGDTC) was successfully labeled with the (99m)Tc(CO)3 core to provide the corresponding (99m)Tc(CO)3-DGDTC complex in good yields. The radiochemical purity of the (99m)Tc(CO)3-DGDTC complex was over 90%, as measured by high performance liquid chromatography (HPLC). The complex possessed good stability in saline at room temperature and in mouse plasma at 37 °C. Its partition coefficient result indicated that it was a hydrophilic complex. The electrophoresis results showed the complex was neutral. The biodistribution of (99m)Tc(CO)3-DGDTC in mice bearing S 180 tumor showed that the complex clearly accumulated in tumor, exhibiting high tumor/blood and tumor/muscle ratios and good tumor retention. Single photon emission computed tomography (SPECT) image studies showed there was a visible uptake in tumor sites, suggesting (99m)Tc(CO)3-DGDTC could be considered as a potential tumor imaging agent.
authors.affiliation: Key Laboratory of Radiopharmaceuticals (Beijing Normal University), Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, PR China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Lin
authors.affiliation: Key Laboratory of Radiopharmaceuticals (Beijing Normal University), Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, PR China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Chao
authors.affiliation: Key Laboratory of Radiopharmaceuticals (Beijing Normal University), Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, PR China. Electronic address: zhjunbo@bnu.edu.cn.
authors.forename: Junbo
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Nuclear Medicine Department, Peking University 3rd Hospital, Beijing 100191, PR China. Electronic address: jinzhonghui@163.com.
authors.forename: Zhonghui
authors.initials: Z
authors.lastname: Jin
authors.affiliation: Nuclear Medicine Department, Peking University 3rd Hospital, Beijing 100191, PR China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002219:Carbamates / Q000737:chemistry*; D003847:Deoxyglucose / Q000031:analogs & derivatives* / Q000737:chemistry; D051379:Mice; D015609:Organotechnetium Compounds / Q000737:chemistry / Q000493:pharmacokinetics*; D012510:Sarcoma 180 / Q000188:drug therapy*; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D002219:Carbamates; D015609:Organotechnetium Compounds; C541546:deoxyglucose dithiocarbamate; D003847:Deoxyglucose
keywords: (99m)Tc tricarbonyl complex; Deoxyglucose; Dithiocarbamate; Tumor imaging agent