title: Interrelatedness between C-reactive protein and oxidized low-density lipoprotein.
abstract: C-reactive protein (CRP) is a marker of inflammation. Atherosclerosis is now recognized as inflammatory disease, and it seems that CRP directly contributes to atherogenesis. Oxidation of low-density lipoprotein (LDL) molecule increases the uptake of lipid products by macrophages leading to cholesterol accumulation and subsequent foam cell formation. The elevated levels of high sensitivity CRP (hsCRP) and oxidized LDL (OxLDL) in the blood were found to be associated with cardiovascular diseases (CVD). In this review, we highlighted the evidence that CRP and OxLDL are involved in interrelated (patho) physiological pathways. The findings on association between hsCRP and OxLDL in the clinical setting will be also summarized.
authors.forename: Milan M
authors.initials: MM
authors.lastname: Obradovic
authors.forename: Andreja
authors.initials: A
authors.lastname: Trpkovic
authors.forename: Vladan
authors.initials: V
authors.lastname: Bajic
authors.forename: Sanja
authors.initials: S
authors.lastname: Soskic
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Jovanovic
authors.forename: Julijana
authors.initials: J
authors.lastname: Stanimirovic
authors.forename: Milos
authors.initials: M
authors.lastname: Panic
authors.forename: Esma R
authors.initials: ER
authors.lastname: Isenovic
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism*; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood / Q000378:metabolism*; D053482:beta 2-Glycoprotein I / Q000378:metabolism
chemical_list: D008077:Lipoproteins, LDL; D053482:beta 2-Glycoprotein I; C099252:oxidized low density lipoprotein; D002097:C-Reactive Protein