title: Malaria and vascular endothelium.
abstract: Involvement of the cardiovascular system in patients with infectious and parasitic diseases can result from both intrinsic mechanisms of the disease and drug intervention. Malaria is an example, considering that the endothelial injury by Plasmodium-infected erythrocytes can cause circulatory disorders. This is a literature review aimed at discussing the relationship between malaria and endothelial impairment, especially its effects on the cardiovascular system. We discuss the implications of endothelial aggression and the interdisciplinarity that should guide the malaria patient care, whose acute infection can contribute to precipitate or aggravate a preexisting heart disease.
authors.affiliation: Universidade Federal do Amazonas, Manaus, AM, Brazil.
authors.forename: Aristóteles Comte de
authors.initials: AC
authors.lastname: Alencar Filho
authors.affiliation: Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, AM, Brazil.
authors.forename: Marcus Vinícius Guimarães de
authors.initials: MV
authors.lastname: Lacerda
authors.affiliation: Faculdade de Medicina de Botucatu, Unesp, Botucatu, SP, Brazil.
authors.forename: Katashi
authors.initials: K
authors.lastname: Okoshi
authors.affiliation: Faculdade de Medicina de Botucatu, Unesp, Botucatu, SP, Brazil.
authors.forename: Marina Politi
authors.initials: MP
authors.lastname: Okoshi
mesh_terms: D002318:Cardiovascular Diseases / Q000469:parasitology* / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000469:parasitology* / Q000503:physiopathology; D004912:Erythrocytes / Q000469:parasitology; D006801:Humans; D008288:Malaria / Q000150:complications* / Q000503:physiopathology; D010961:Plasmodium