title: [State of the art and perspectives of accelerated partial breast irradiation in 2014].
abstract: In the frame of treatment de-escalation and personalization, accelerated partial breast irradiation is taking its place in the breast cancer therapeutic options. This study analyzed the results of phase III randomized trials having compared accelerated partial breast irradiation versus whole breast irradiation. Currently, among those trails, six proposed some results regarding efficacy and/or toxicity. Globally, the non-randomized studies confirmed the expected results showing a low rate of local recurrence and toxicity. The first results of the phase III randomized trials showed encouraging data in terms of local control while the toxicity varied mainly according to the accelerated partial breast irradiation technique used. However, the follow-up of the majority of these studies remains insufficient. The strict respect of accelerated partial breast irradiation indications likely represents one of the key factors of the therapeutic success. The next results could allow proposing a better definition of the accelerated partial breast irradiation selection criteria.
authors.affiliation: Pôle de radiothérapie, centre Antoine-Lacassagne, université Nice-Sophia, 33, avenue de Valombrose, 06189 Nice cedex, France.
authors.forename: M-È
authors.initials: MÈ
authors.lastname: Chand-Fouché
authors.affiliation: Pôle de radiothérapie, centre Antoine-Lacassagne, université Nice-Sophia, 33, avenue de Valombrose, 06189 Nice cedex, France. Electronic address: jean-michel.hannoun-levi@nice.unicancer.fr.
authors.forename: J-M
authors.initials: JM
authors.lastname: Hannoun-Lévi
mesh_terms: D001918:Brachytherapy; D001943:Breast Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D017326:Clinical Trials, Phase III as Topic; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental; D020360:Neoadjuvant Therapy; D018714:Radiotherapy, Adjuvant; D016032:Randomized Controlled Trials as Topic
keywords: Accelerated partial breast irradiation; Brachytherapy; Breast cancer; Cancer du sein; Curiethérapie; Hypofractionated radiotherapy; Intra-operative radiotherapy; Irradiation intra-opératoire; Irradiation partielle et accélérée; Radiothérapie hypofractionnée; Toxicity; Toxicité