title: Prolactinomas, cabergoline, and pregnancy.
abstract: Hyperprolactinemia, frequently caused by a prolactinoma, is an important cause of infertility among young women. Dopamine agonists (DA) are the treatment of choice. Although cabergoline (CAB) is currently considered the gold standard DA, bromocriptine (BRC) remains the drug of choice for women desiring pregnancy, as it was proven to be safe in more than 6,000 pregnancies. The purpose of this review is to perform a critical evaluation of CAB safety in pregnancy, as it is used by most patients harboring prolactinomas. Although the number of CAB-induced pregnancies (about 800) is still reduced as compared with those under BRC treatment, data in the literature do not point to increase risk of preterm delivery or fetal malformations, comparing to pregnancies induced by BRC and those in the general population. Moreover, CAB use throughout pregnancy was reported in about ten cases, without evidence of any harm to fetal development. Therefore, even though BRC still remains the recommended DA drug for pregnancy induction or use during pregnancy in women with prolactinomas, increasing evidences point to the safety of CAB for this purpose.
authors.affiliation: Neuroendocrine Unit, Division of Endocrinology and Metabolism Hospital das Clinicas, University of Sao Paulo Medical School, Sao Paulo, Brazil.
authors.forename: Andrea
authors.initials: A
authors.lastname: Glezer
authors.forename: Marcello D
authors.initials: MD
authors.lastname: Bronstein
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000077465:Cabergoline; D004873:Ergolines / Q000627:therapeutic use*; D005260:Female; D047109:Fetal Development / Q000187:drug effects; D006801:Humans; D006966:Hyperprolactinemia / Q000188:drug therapy / Q000209:etiology; D007247:Infertility, Female / Q000188:drug therapy / Q000209:etiology; D010911:Pituitary Neoplasms / Q000150:complications* / Q000188:drug therapy*; D011247:Pregnancy / Q000502:physiology; D015175:Prolactinoma / Q000150:complications* / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D004873:Ergolines; D000077465:Cabergoline