title: Protective effect of Artemisia annua L. extract against galactose-induced oxidative stress in mice.
abstract: Artemisia annua L. (also called qinghao) has been well known as a source of antimalarial drug artemisinins. In addition, the herb was reported to have in vitro antioxidative activity. The present study investigated the protective effect of aqueous ethanol extract of Qinghao (AA extract) against D-galactose-induced oxidative stress in C57BL/6J mice. Feeding AA extract-containing diet lowered serum levels of malondialdehyde and 8-OH-dG that are biomarkers for lipid peroxidation and DNA damage, respectively. Furthermore, AA extract feeding enhanced the activity of NQO1, a typical antioxidant marker enzyme, in tissues such as kidney, stomach, small intestine, and large intestine. In conclusion, AA extract was found to have antioxidative activity in mouse model.
authors.affiliation: School of Food Science and Biotechnology, Kyungpook National University, Daegu, Republic of Korea.
authors.forename: Mi Hye
authors.initials: MH
authors.lastname: Kim
authors.affiliation: School of Food Science and Biotechnology, Kyungpook National University, Daegu, Republic of Korea.
authors.forename: Ji Yeon
authors.initials: JY
authors.lastname: Seo
authors.affiliation: College of Pharmacy, Kyungpook National University, Daegu, Republic of Korea.
authors.forename: Kwang Hyun
authors.initials: KH
authors.lastname: Liu
authors.affiliation: School of Food Science and Biotechnology, Kyungpook National University, Daegu, Republic of Korea.
authors.forename: Jong-Sang
authors.initials: JS
authors.lastname: Kim
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D031172:Artemisia annua / Q000737:chemistry*; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism; D019587:Dietary Supplements / Q000032:analysis; D005690:Galactose / Q000009:adverse effects*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008810:Mice, Inbred C57BL; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D000080242:8-Hydroxy-2'-Deoxyguanosine; D016660:NAD(P)H Dehydrogenase (Quinone); C491732:Nqo1 protein, mouse; D003849:Deoxyguanosine; D005690:Galactose