title: Comparative study on the predictability of statistical models (RSM and ANN) on the behavior of optimized buccoadhesive wafers containing Loratadine and their in vivo assessment.
abstract: OBJECTIVE
  Buccoadhesive wafer dosage form containing Loratadine is formulated utilizing Formulation by Design (FbD) approach incorporating sodium alginate and lactose monohydrate as independent variable employing solvent casting method.
  
  
  METHODS
  The wafers were statistically optimized using Response Surface Methodology (RSM) and Artificial Neural Network algorithm (ANN) for predicting physicochemical and physico-mechanical properties of the wafers as responses. Morphologically wafers were tested using SEM. Quick disintegration of the samples was examined employing Optical Contact Angle (OCA).
  
  
  RESULTS
  The comparison of the predictability of RSM and ANN showed a high prognostic capacity of RSM model over ANN model in forecasting mechanical and physicochemical properties of the wafers. The in vivo assessment of the optimized buccoadhesive wafer exhibits marked increase in bioavailability justifying the administration of Loratadine through buccal route, bypassing hepatic first pass metabolism.
authors.affiliation: a Bengal College of Pharmaceutical Sciences and Research , West Bengal University of Technology , B.R.B. Sarani , Durgapur , West Bengal , India and.
authors.forename: Prithviraj
authors.initials: P
authors.lastname: Chakraborty
authors.affiliation: b S. Bhagwan Singh PG Institute of Biomedical Sciences and Research , Balawala , Dehradun , Uttarakhand , India.
authors.forename: Versha
authors.initials: V
authors.lastname: Parcha
authors.affiliation: a Bengal College of Pharmaceutical Sciences and Research , West Bengal University of Technology , B.R.B. Sarani , Durgapur , West Bengal , India and.
authors.forename: Debarupa D
authors.initials: DD
authors.lastname: Chakraborty
authors.affiliation: a Bengal College of Pharmaceutical Sciences and Research , West Bengal University of Technology , B.R.B. Sarani , Durgapur , West Bengal , India and.
authors.forename: Amitava
authors.initials: A
authors.lastname: Ghosh
mesh_terms: D000269:Adhesives / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics; D000278:Administration, Buccal; D000818:Animals; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004304:Dosage Forms; D017336:Loratadine / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics; D008297:Male; D015233:Models, Statistical; D009061:Mouth Mucosa / Q000378:metabolism*; D016571:Neural Networks, Computer; D011817:Rabbits
chemical_list: D000269:Adhesives; D004304:Dosage Forms; D017336:Loratadine
keywords: ANN; Loratadine; RSM; buccoadhesive; in vivo; optimization; wafer