title: Insecticidal quinoline and isoquinoline isoxazolines.
abstract: A series of quinoline and isoquinoline isoxazolines have been designed as pesticides for crop protection. Herein we reported the chemical synthesis, biological activity and structure-activity relationships. The isoquinoline derivative, such as 3i, is discovered as potent new class of isoxazoline insecticide which is competitive with commercial insecticide Indoxacarb.
authors.affiliation: DuPont Crop Protection, Stine-Haskell Research Center, 1094 Elkton Road, Newark, DE 19711, USA. Electronic address: ming.xu@dupont.com.
authors.forename: Ming
authors.initials: M
authors.lastname: Xu
authors.affiliation: DuPont Crop Protection, Stine-Haskell Research Center, 1094 Elkton Road, Newark, DE 19711, USA.
authors.forename: Ty
authors.initials: T
authors.lastname: Wagerle
authors.affiliation: DuPont Crop Protection, Stine-Haskell Research Center, 1094 Elkton Road, Newark, DE 19711, USA.
authors.forename: Jeffrey K
authors.initials: JK
authors.lastname: Long
authors.affiliation: DuPont Crop Protection, Stine-Haskell Research Center, 1094 Elkton Road, Newark, DE 19711, USA.
authors.forename: George P
authors.initials: GP
authors.lastname: Lahm
authors.affiliation: DuPont Crop Protection, Stine-Haskell Research Center, 1094 Elkton Road, Newark, DE 19711, USA.
authors.forename: James D
authors.initials: JD
authors.lastname: Barry
authors.affiliation: DuPont Crop Protection, Stine-Haskell Research Center, 1094 Elkton Road, Newark, DE 19711, USA.
authors.forename: Rejane M
authors.initials: RM
authors.lastname: Smith
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D006430:Hemiptera / Q000187:drug effects*; D007306:Insecticides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D007546:Isoquinolines / Q000737:chemistry; D007555:Isoxazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D009036:Moths / Q000187:drug effects*; D011804:Quinolines / Q000737:chemistry; D061149:Thysanoptera / Q000187:drug effects*
chemical_list: D007306:Insecticides; D007546:Isoquinolines; D007555:Isoxazoles; D011804:Quinolines; C037219:quinoline; C039109:isoquinoline
keywords: Insecticide; Isoquinoline; Isoxazoline; Quinoline