title: The effects of positioning of transcatheter aortic valves on fluid dynamics of the aortic root.
abstract: Transcatheter aortic valve implantation is a novel treatment for severe aortic valve stenosis. Due to the recent use of this technology and the procedural variability, there is very little data that quantify the hemodynamic consequences of variations in valve placement. Changes in aortic wall stresses and fluid retention in the sinuses of Valsalva can have a significant effect on the clinical response a patient has to the procedure. By comprehensively characterizing complex flow in the sinuses of Valsalva using digital particle image velocimetry and an advanced heart-flow simulator, various positions of a deployed transcatheter valve with respect to a bioprosthetic aortic valve (valve-in-valve) were tested in vitro. Displacements of the transcatheter valve were axial and directed below the simulated native valve annulus. It was determined that for both blood residence time and aortic Reynolds stresses, it is optimal to have the annulus of the transcatheter valve deployed as close to the aortic valve annulus as possible.
authors.affiliation: Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California at Irvine.|Division of Cardiovascular Diseases, University of California at Irvine.
authors.forename: Elliott M
authors.initials: EM
authors.lastname: Groves
authors.affiliation: Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California at Irvine.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Falahatpisheh
authors.affiliation: Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California at Irvine.|Department of Biomedical Engineering, University of California at Irvine.
authors.forename: Jimmy L
authors.initials: JL
authors.lastname: Su
authors.affiliation: Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California at Irvine.|Division of Cardiovascular Diseases, University of California at Irvine.|Department of Biomedical Engineering, University of California at Irvine.
authors.forename: Arash
authors.initials: A
authors.lastname: Kheradvar
mesh_terms: D001011:Aorta / Q000601:surgery*; D001021:Aortic Valve; D001024:Aortic Valve Stenosis / Q000601:surgery; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D057446:Hydrodynamics; D066298:In Vitro Techniques; D065467:Transcatheter Aortic Valve Replacement / Q000379:methods*