title: A case of bilateral human herpes virus 6 panuveitis with genomic viral DNA integration.
abstract: BACKGROUND
  We report a rare case of bilateral panuveitis from human herpes virus 6 (HHV-6) with genomic viral DNA integration in an immunocompromised man.
  
  
  RESULTS
  A 59-year-old man with history of multiple myeloma presented with altered mental status, bilateral eye redness, and blurry vision. Examination revealed bilateral diffuse keratic precipitates, 4+ anterior chamber cell, hypopyon, vitritis, and intraretinal hemorrhages. Intraocular fluid testing by polymerase chain reaction (PCR) was positive for HHV-6. The patient was successfully treated with intravitreal foscarnet and intravenous ganciclovir and foscarnet. Despite clinical improvement, his serum HHV-6 levels remained high, and it was concluded that he had HHV-6 chromosomal integration.
  
  
  CONCLUSIONS
  HHV-6 should be considered in the differential for infectious uveitis in immunocompromised hosts who may otherwise have a negative work-up. HHV-6 DNA integration may lead to difficulties in disease diagnosis and determining disease resolution.
authors.affiliation: Department of Ophthalmology, Mayo Clinic, 200 First Street SW, Rochester 55905, MN, USA.
authors.forename: Jasmina
authors.initials: J
authors.lastname: Bajric
authors.affiliation: Department of Ophthalmology, Mayo Clinic, 200 First Street SW, Rochester 55905, MN, USA.
authors.forename: Wendy M
authors.initials: WM
authors.lastname: Smith
keywords: Chromosomal integration; HHV-6; Human herpes virus-6; Immunocompromise; PCR; Panuveitis