title: Levels of heavy metals and trace elements in umbilical cord blood and the risk of adverse pregnancy outcomes: a population-based study.
abstract: To better understand the relationship between prenatal exposure to heavy metals and trace elements and the risk of adverse pregnancy outcomes, we investigated the status of heavy metals and trace elements level in a Chinese population by collecting umbilical cord blood. Umbilical cord blood heavy metals and trace elements concentrations were determined by inductively coupled plasma-mass spectrometry. No differences with statistical significance in the median arsenic (As), cadmium (Cd), cobalt (Co), chromium (Cr), copper (Cu), manganese (Mn), nickel (Ni), lead (Pb), strontium (Sr), thallium (Tl), vanadium (V), and zinc (Zn) concentrations were observed between the adverse pregnancy outcome group and the reference group. Titanium (Ti) and antimony (Sb) were found at higher levels with statistical significance in the cord blood samples with adverse pregnancy group when compared to the ones in the reference group. The association between Ti levels and the risk of adverse pregnancy outcomes remained significant after adjusting for potential confounding factors, including newborn weight. These results indicated that environmental exposure to Ti may increase the risk of adverse pregnancy outcomes in Chinese women without occupational exposure.
authors.affiliation: State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, 361102, China.
authors.forename: Guanchao
authors.initials: G
authors.lastname: Zheng
authors.forename: Hongxiu
authors.initials: H
authors.lastname: Zhong
authors.forename: Zhizhun
authors.initials: Z
authors.lastname: Guo
authors.forename: Zhuangchu
authors.initials: Z
authors.lastname: Wu
authors.forename: Huaiqing
authors.initials: H
authors.lastname: Zhang
authors.forename: Chonggang
authors.initials: C
authors.lastname: Wang
authors.forename: Yulin
authors.initials: Y
authors.lastname: Zhou
authors.forename: Zhenghong
authors.initials: Z
authors.lastname: Zuo
mesh_terms: D000328:Adult; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D006801:Humans; D019216:Metals, Heavy / Q000097:blood*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood*; D011256:Pregnancy Outcome; D012307:Risk Factors; D014131:Trace Elements / Q000097:blood*
chemical_list: D019216:Metals, Heavy; D014131:Trace Elements