title: Bone marrow derived stem cells in trauma and orthopaedics: a review of the current trend.
abstract: Bone tissue engineering is a promising therapeutic option to enhance tissue regeneration and repair. The development of bone tissue engineering is directly related to changes in materials technology. While the inclusion of material requirements is standard in the design process of engineered bone substitutes, it is critical to incorporate clinical requirements in order to engineer a clinically relevant device. This review focuses on the potentials of bone marrow derived mesenchymal stem cells (BM-MSCs) in trauma and orthopaedics and presents the need for bone tissue-engineered alternatives.
authors.forename: Jagwant
authors.initials: J
authors.lastname: Singh
authors.forename: Jemina O
authors.initials: JO
authors.lastname: Onimowo
authors.affiliation: University College London Institute of Orthopaedics and Musculoskeletal Sciences, Royal National Orthopaedic Hospital, Stanmore, HA7 4LP, UK. wasimkhan@doctors.org.uk.
authors.forename: Wasim S
authors.initials: WS
authors.lastname: Khan
mesh_terms: D001854:Bone Marrow Cells / Q000166:cytology*; D002454:Cell Differentiation; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000639:trends*; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D009985:Orthopedics; D014947:Wounds and Injuries / Q000628:therapy*