title: The impact of hepatitis B infection on outcome of kidney transplantation: a long-term study.
abstract: BACKGROUND
  With the success of kidney transplantation, liver disease has emerged as an important cause of morbidity and mortality in kidney recipients.
  
  
  OBJECTIVE
  To determine the impact of hepatitis B virus (HBV) infection on patients and graft survival in both short- and long-terms.
  
  
  METHODS
  99 renal transplant patients infected with HBV on follow-up in two major transplant centers were included in a retrospective study. These patients were grafted between 1986 and 2005 and divided into two groups: (1) those only positive for hepatitis B surface antigen (HBsAg) and (2) those who were also positive for hepatitis C virus antibodies (HCV Ab).
  
  
  RESULTS
  There were 88 patients with HBsAg(+) and 11 with both HBsAg(+) and HCV Ab(+). The mean±SD age of patients was 38.8±13.2 years, and the median follow-up after transplantation was 19 months. Although not significant, the allograft survival rate in the first group (HBV(+)) was better compared to that in the second group (HBV(+) and HCV(+)); 1, 5 and 10 years graft survival rates were 91, 77 and 62 in the first group and 70, 56 and 28 in the second group, respectively (P=0.07). The overall mortality was 5% (4 of 88) in the first and 27% (3 of 11) in the second group (P=0.02).
  
  
  CONCLUSIONS
  Renal allograft recipients with HBV and HCV infections has a poor survival rate compared to patients with only HBV infection. However, there is no significant difference in terms of renal graft survival between the two groups.
authors.affiliation: Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.
authors.forename: B
authors.initials: B
authors.lastname: Einollahi
authors.affiliation: Baqiyatallah Research Center for Gastroenterology and Liver Disease, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.
authors.forename: S M
authors.initials: SM
authors.lastname: Alavian
authors.affiliation: Department of Nephrology, Tehran University of Medical Sciences, Tehran, IR Iran.
authors.forename: M
authors.initials: M
authors.lastname: Lessan-Pezeshki
authors.affiliation: Renal Transplantation Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
authors.forename: N
authors.initials: N
authors.lastname: Simforoosh
authors.affiliation: Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.
authors.forename: M H
authors.initials: MH
authors.lastname: Nourbala
authors.affiliation: Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.
authors.forename: Z
authors.initials: Z
authors.lastname: Rostami
authors.affiliation: Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.
authors.forename: V
authors.initials: V
authors.lastname: Pourfarziani
authors.affiliation: Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.
authors.forename: E
authors.initials: E
authors.lastname: Nemati
authors.affiliation: Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.
authors.forename: M
authors.initials: M
authors.lastname: Sharafi
authors.affiliation: Renal Transplantation Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
authors.forename: M
authors.initials: M
authors.lastname: Nafar
authors.affiliation: Renal Transplantation Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
authors.forename: F
authors.initials: F
authors.lastname: Pour-Reza Gholi
authors.affiliation: Renal Transplantation Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
authors.forename: A
authors.initials: A
authors.lastname: Firoozan
keywords: Hepatitis B virus; Hepatitis C virus; Kidney transplantation