title: Association of carotid intima-media thickness with leptin and apoliprotein b/apoliprotein a-I ratio reveals imminent predictors of subclinical atherosclerosis in psoriasis patients.
abstract: Psoriasis patients are often susceptible to cardiovascular diseases (CVD), including atherosclerosis. Traditional markers (biochemical and inflammatory) and diagnostic tools could detect occlusive but not subclinical atherosclerosis. Carotid intima-media thickness (CIMT), has recently been recognised as a non invasive diagnostic tool for identification of premature atherosclerosis. Therefore we evaluated 80 psoriasis patients and 80 age sex matched healthy controls for serum leptin levels and apolipoprotein B/apolipoprotein A-I ratio (apoB/apoA-I ratio) in relation with CIMT of carotid artery. Carotid intima-media thickness and carotid plaques were simultaneously measured by carotid sonography. Serum concentration of leptin and apolipoprotein were measured using enzyme-linked immuno sorbent assay (ELISA) and nephelometry respectively. Raised CIMT correlated to age of onset of the disease, serum leptin and apoB/apoA-I ratio in psoriasis patients. Taking into account, values that were above the 75 percentile of the three markers (leptin, apoB/apoA-I ratio and CIMT) the odds ratio was 4.26 (2.06-8.80 CI). Leptin and apoB/apoA-I ratio showed significant cumulative association with CIMT. Results of predictive analysis supports measurement of CIMT along with estimation of serum leptin and apoB/apoA-I ratio for prediction of premature atherosclerosis in psoriasis patients.
authors.affiliation: University College of Medical Sciences and G.T.B. Hospital, Dilshad Garden, University of Delhi, India: Department of Biochemistry.
authors.forename: Kumari
authors.initials: K
authors.lastname: Asha
authors.affiliation: University College of Medical Sciences and G.T.B. Hospital, Dilshad Garden, University of Delhi, India: Department of Biochemistry.
authors.forename: Suman B
authors.initials: SB
authors.lastname: Sharma
authors.affiliation: University College of Medical Sciences and G.T.B. Hospital, Dilshad Garden, University of Delhi, India: Department of Dermatology.
authors.forename: Archana
authors.initials: A
authors.lastname: Singal
authors.affiliation: University College of Medical Sciences and G.T.B. Hospital, Dilshad Garden, University of Delhi, India: Department of Medicine.
authors.forename: Amitesh
authors.initials: A
authors.lastname: Aggarwal
mesh_terms: D000328:Adult; D016632:Apolipoprotein A-I / Q000097:blood*; D001055:Apolipoproteins B / Q000097:blood*; D050197:Atherosclerosis / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011565:Psoriasis / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging
chemical_list: D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D020738:Leptin
keywords: Apolipoprotein; Atherosclerosis; CIMT; Psoriasis; apoB/apoA-I, Leptin