title: A new antioxidant flavone glycoside from Scutellaria baicalensis Georgi.
abstract: A new flavone glycoside, wogonin 7-O-β-D-ethylglucuronide (1), together with a new natural flavone glycoside baicalein 7-O-β-D-ethylglucuronide (2) and four known analogues, wogonoside (3), wogonin (4), oroxylin A 7-O-β-D-methylglucuronide (5) and oroxylin A (6), was isolated from the roots of Scutellaria baicalensis Georgi. The structure elucidation of the new compound was primarily based on HR-ESI-MS, 1D and 2D NMR analyses. Compounds 1 and 3 inhibited FeSO4-Cys-induced liver homogenate lipid peroxidation with IC50 at 18.2 μM and 24.9 μM, respectively, and exhibited strong cytoprotective effects against H2O2-induced oxidative damage in human umbilical vein endothelial cells at low concentrations of 10.0 μM and 3.0 μM.
authors.affiliation: a Department of Natural Medicinal Chemistry , China Pharmaceutical University , 639 Longmian Avenue, Nanjing 211198 , P.R. China.
authors.forename: Meng-Hua
authors.initials: MH
authors.lastname: Wang
authors.forename: Lin-Zhen
authors.initials: LZ
authors.lastname: Li
authors.forename: Jian-Bo
authors.initials: JB
authors.lastname: Sun
authors.forename: Fei-Hua
authors.initials: FH
authors.lastname: Wu
authors.forename: Jing-Yu
authors.initials: JY
authors.lastname: Liang
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification; D044950:Flavanones / Q000737:chemistry* / Q000302:isolation & purification; D047309:Flavones / Q000737:chemistry* / Q000302:isolation & purification; D020719:Glucuronides / Q000737:chemistry* / Q000302:isolation & purification; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects; D006801:Humans; D015227:Lipid Peroxidation; D008099:Liver / Q000187:drug effects; D015394:Molecular Structure; D018384:Oxidative Stress; D018517:Plant Roots / Q000737:chemistry*; D051381:Rats; D031364:Scutellaria baicalensis / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D044950:Flavanones; D047309:Flavones; D020719:Glucuronides; D006027:Glycosides; C000597086:wogonin 7-O-beta-D-ethylglucuronide; C043562:flavone
keywords: Scutellaria baicalensis Georgi; aitilipid-peroxidation; cytoprotective; flavone glycosides; wogonin 7-O-β-d-ethylglucuronide