title: [A rare case of acute promyelocytic leukemia accompanied by benign craniopharyngioma].
abstract: The purpose of study was to analysis the clinical manifestation and treatment protocol of acute promyelocytic leukemia (APL) accompanied by craniopharyngioma so as to promote the understanding of this disease. The APL was diagnosed by morphologic examination of bone marrow cells, the leukemia bone marrow cells were analyzed by immunophenotyping technique, the qualitative and quantitative changes of PML-PARα fusion gene before and after treatment were monitored by using molecular biological test; the cytogenetic features were analyzed by using conventional karyotype and FISH analysis. The results indicated that the clinical manifestation of this disease was diverse and disease status was complex. The good therapeutic efficacy could be achieved, the misdiagnosis and delayed treatment could be avoided through early detection, timely treatment and multidisciplinary cooperation. It is concluded that when other clinical symptoms reappear after APL achieves remission, the possibility of second tumor must be considered, the clinical presentation should be carefully monitored, the early detection and timely treatment should be performed to improve the survival of patients.
authors.affiliation: Department of Hematology, People's Hospital of Gaochun County, Gaochun 211300, Jiangsu Province, China; Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Cheng-Ying
authors.initials: CY
authors.lastname: Zhu
authors.affiliation: Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China; Department of Hematology and Oncology, The Forth People's Hospital of Jinan, Jinan 250031, Shandong Province, China.
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Niu
authors.affiliation: Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Xu
authors.affiliation: Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Nai
authors.initials: N
authors.lastname: Wang
authors.affiliation: Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Zhu
authors.affiliation: Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Li
authors.initials: L
authors.lastname: Yu
authors.affiliation: Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China. E-mail: jingyu301@163.com.
authors.forename: Yu
authors.initials: Y
authors.lastname: Jing
mesh_terms: D003397:Craniopharyngioma / Q000150:complications*; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000150:complications*