title: Markers of epidermal stem cell subpopulations in adult mammalian skin.
abstract: The epidermis is the outermost layer of mammalian skin and comprises a multilayered epithelium, the interfollicular epidermis, with associated hair follicles, sebaceous glands, and eccrine sweat glands. As in other epithelia, adult stem cells within the epidermis maintain tissue homeostasis and contribute to repair of tissue damage. The bulge of hair follicles, where DNA-label-retaining cells reside, was traditionally regarded as the sole epidermal stem cell compartment. However, in recent years multiple stem cell populations have been identified. In this review, we discuss the different stem cell compartments of adult murine and human epidermis, the markers that they express, and the assays that are used to characterize epidermal stem cell properties.
authors.affiliation: Centre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital, London SE1 9RT, United Kingdom Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 1QR, United Kingdom Department of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom.
authors.forename: Kai
authors.initials: K
authors.lastname: Kretzschmar
authors.affiliation: Centre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital, London SE1 9RT, United Kingdom.
authors.forename: Fiona M
authors.initials: FM
authors.lastname: Watt
mesh_terms: D053687:Adult Stem Cells / Q000737:chemistry*; D000818:Animals; D019070:Cell Lineage / Q000235:genetics; D003114:Colony-Forming Units Assay; D004439:Eccrine Glands / Q000737:chemistry / Q000166:cytology; D000078404:Epidermal Cells; D004817:Epidermis / Q000737:chemistry*; D018859:Hair Follicle / Q000737:chemistry / Q000166:cytology; D006801:Humans; D051379:Mice; D012627:Sebaceous Glands / Q000737:chemistry* / Q000166:cytology