title: Green synthesis and antioxidant activity of novel γ-cyano-α- hydroxyphosphonate derivatives.
abstract: Herein we report an efficient, simple and green synthesis of novel types of α-hydroxyphosphonates bearing a nitrile group, from the reaction of γ-ketonitriles with dialkyl phosphites in the presence of magnesium oxide as solid support, under solvent-free conditions. All the title compounds were screened for their antioxidant activity by 1,1-diphenyl-2- picrylhydrazyl (DPPH), hydroxyl radical, reducing power and ferrous ion chelating (FIC) methods and they showed significant antioxidant activity.
authors.forename: Iyadh
authors.initials: I
authors.lastname: Aouani
authors.forename: Karima
authors.initials: K
authors.lastname: Lahbib
authors.affiliation: Laboratory of Heteroatom Organic Chemistry, Department of Chemistry, Faculty of Sciences of Bizerta, University of Carthage, 7021-Jarzouna, Tunisia. soufiane.touil@fsb.rnu.tn.
authors.forename: Soufiane
authors.initials: S
authors.lastname: Touil
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000737:chemistry; D015195:Drug Design; D005609:Free Radicals / Q000737:chemistry; D055772:Green Chemistry Technology; D007502:Iron Chelating Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010851:Picrates / Q000737:chemistry
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D005609:Free Radicals; D007502:Iron Chelating Agents; D063065:Organophosphonates; D010851:Picrates; C004931:1,1-diphenyl-2-picrylhydrazyl