title: Validation of the Spanish version of Addenbrooke's Cognitive Examination III for diagnosing dementia.
abstract: BACKGROUND
  Addenbrooke's Cognitive Examination is a screening test used to diagnose dementia. The third edition of this test (ACE-III) was recently developed. The aim of this study was to translate and validate the ACE-III in Spanish.
  
  
  METHODS
  The ACE-III was translated and adapted to Spanish. It was then administered to a group of healthy subjects as well as a group of patients with different types of mild dementia treated in 2 hospitals in Spain.
  
  
  RESULTS
  Internal reliability (Cronbach's alpha = 0.927), inter-rater reliability (intraclass correlation coefficient = 0.976) and test-retest reliability (kappa 0.995) were excellent. Age (r = -0.512) and education (r = 0.659) showed a significant correlation with total test scores. The diagnostic accuracy of ACE-III was higher than that of the Mini-Mental State Examination, particularly for the group with the highest educational level. Researchers obtained normative data and cut-off points for the diagnosis of dementia.
  
  
  CONCLUSIONS
  The Spanish version of the ACE-III is a reliable and valid test for diagnosing dementia. Its diagnostic accuracy is high, especially in patients with a higher level of education.
authors.affiliation: Servicio de Neurología, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria «San Carlos», Universidad Complutense, Madrid, España. Electronic address: jordimatiasguiu@hotmail.com.
authors.forename: J A
authors.initials: JA
authors.lastname: Matias-Guiu
authors.affiliation: Servicio de Neurología, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Institut d'Investigacions Biosanitàries Sant Pau , Barcelona, España.
authors.forename: R
authors.initials: R
authors.lastname: Fernández de Bobadilla
authors.affiliation: Servicio de Neurología, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria «San Carlos», Universidad Complutense, Madrid, España.
authors.forename: G
authors.initials: G
authors.lastname: Escudero
authors.affiliation: Servicio de Neurología, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Institut d'Investigacions Biosanitàries Sant Pau , Barcelona, España.
authors.forename: J
authors.initials: J
authors.lastname: Pérez-Pérez
authors.affiliation: Servicio de Neurología, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria «San Carlos», Universidad Complutense, Madrid, España.
authors.forename: A
authors.initials: A
authors.lastname: Cortés
authors.affiliation: Servicio de Neurología, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Institut d'Investigacions Biosanitàries Sant Pau , Barcelona, España.
authors.forename: E
authors.initials: E
authors.lastname: Morenas-Rodríguez
authors.affiliation: Servicio de Neurología, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria «San Carlos», Universidad Complutense, Madrid, España.
authors.forename: M
authors.initials: M
authors.lastname: Valles-Salgado
authors.affiliation: Servicio de Neurología, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria «San Carlos», Universidad Complutense, Madrid, España.
authors.forename: T
authors.initials: T
authors.lastname: Moreno-Ramos
authors.affiliation: Servicio de Neurología, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Institut d'Investigacions Biosanitàries Sant Pau , Barcelona, España.
authors.forename: J
authors.initials: J
authors.lastname: Kulisevsky
authors.affiliation: Servicio de Neurología, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria «San Carlos», Universidad Complutense, Madrid, España.
authors.forename: J
authors.initials: J
authors.lastname: Matías-Guiu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003072:Cognition Disorders / Q000175:diagnosis* / Q000523:psychology*; D003704:Dementia / Q000175:diagnosis* / Q000523:psychology*; D004522:Educational Status; D005260:Female; D006801:Humans; D007802:Language; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000592:standards*; D015588:Observer Variation; D015203:Reproducibility of Results; D014177:Translations
keywords: Addenbrooke's Cognitive Examination; Alzheimer disease; Cognitive screening; Cribado cognitivo; Demencia; Demencia frontotemporal; Dementia; Enfermedad de Alzheimer; Evaluación neuropsicológica; Frontotemporal dementia; Neuropsychological assessment