title: Cysticidal activity of antifungals against different genotypes of Acanthamoeba.
abstract: Antifungal drugs have been proposed as a novel treatment for Acanthamoeba keratitis. The cysticidal activity of several antifungal compounds was tested against different genotypes of culture collection and clinical isolates of Acanthamoeba. Only voriconazole and posaconazole were found to be cysticidal, with no differences in activity observed between clinical and culture collection isolates.
authors.affiliation: Bascom Palmer Eye Institute, University of Miami-Miller School of Medicine, Miami, Florida, USA Department of Ophthalmology, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy alfonsoiovieno@hotmail.com.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Iovieno
authors.affiliation: Bascom Palmer Eye Institute, University of Miami-Miller School of Medicine, Miami, Florida, USA.
authors.forename: Darlene
authors.initials: D
authors.lastname: Miller
authors.affiliation: Bascom Palmer Eye Institute, University of Miami-Miller School of Medicine, Miami, Florida, USA.
authors.forename: Dolena R
authors.initials: DR
authors.lastname: Ledee
authors.affiliation: Bascom Palmer Eye Institute, University of Miami-Miller School of Medicine, Miami, Florida, USA.
authors.forename: Eduardo C
authors.initials: EC
authors.lastname: Alfonso
mesh_terms: D000048:Acanthamoeba / Q000187:drug effects* / Q000235:genetics; D015823:Acanthamoeba Keratitis / Q000188:drug therapy*; D000562:Amebiasis / Q000188:drug therapy*; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003560:Cysts / Q000188:drug therapy* / Q000469:parasitology; D006801:Humans; D021261:Parasitic Sensitivity Tests; D014230:Triazoles / Q000494:pharmacology / Q000627:therapeutic use; D065819:Voriconazole / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole; D065819:Voriconazole