title: Ascochlorin derivatives from the leafhopper pathogenic fungus Microcera sp. BCC 17074.
abstract: Two new ascochlorin derivatives, nectchlorins A (1) and B (2), together with eight known compounds (3-10), were isolated from cultures of the leafhopper pathogen Microcera sp. BCC 17074. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data. The absolute configuration of 2 was determined by application of the modified Mosher's method. The absolute configuration of LL-Z 1272α epoxide (9), which is a plausible biosynthetic precursor of ascochlorins, was established by chemical correlations. Cytotoxic activities of these ascochlorin derivatives were evaluated.
authors.affiliation: National Center for Genetic Engineering and Biotechnology (BIOTEC), Klong Luang, Pathumthani, Thailand.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Isaka
authors.affiliation: National Center for Genetic Engineering and Biotechnology (BIOTEC), Klong Luang, Pathumthani, Thailand.
authors.forename: Arunrat
authors.initials: A
authors.lastname: Yangchum
authors.affiliation: National Center for Genetic Engineering and Biotechnology (BIOTEC), Klong Luang, Pathumthani, Thailand.
authors.forename: Sumalee
authors.initials: S
authors.lastname: Supothina
authors.affiliation: National Center for Genetic Engineering and Biotechnology (BIOTEC), Klong Luang, Pathumthani, Thailand.
authors.forename: Pattiyaa
authors.initials: P
authors.lastname: Laksanacharoen
authors.affiliation: National Center for Genetic Engineering and Biotechnology (BIOTEC), Klong Luang, Pathumthani, Thailand.
authors.forename: J
authors.initials: J
authors.lastname: Jennifer Luangsa-Ard
authors.affiliation: National Center for Genetic Engineering and Biotechnology (BIOTEC), Klong Luang, Pathumthani, Thailand.
authors.forename: Nigel L
authors.initials: NL
authors.lastname: Hywel-Jones
mesh_terms: D000475:Alkenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002522:Chlorocebus aethiops; D006801:Humans; D006999:Hypocreales / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014709:Vero Cells
chemical_list: D000475:Alkenes; D000970:Antineoplastic Agents; D010636:Phenols; C415745:ascochlorin