title: Pharmacokinetics of cefovecin (Convenia) in white bamboo sharks (Chiloscyllium plagiosum) and Atlantic horseshoe crabs (Limulus polyphemus).
abstract: Cefovecin was administered to six healthy adult white bamboo sharks (Chiloscyllium plagiosum) and six healthy adult Atlantic horseshoe crabs (Limulus polyphemus) to determine its pharmacokinetics in these species. A single dose of cefovecin at 8 mg/kg was administered subcutaneously in the epaxial region of the bamboo sharks and in the proximal articulation of the lateral leg of the horseshoe crabs. Blood and hemolymph samples were collected at various time points from bamboo sharks and Atlantic horseshoe crabs. High performance liquid chromatography was performed to determine plasma levels of cefovecin. The terminal halflife of cefovecin in Atlantic horseshoe crabs was 37.70 +/- 9.04 hr and in white bamboo sharks was 2.02 +/- 4.62 hr. Cefovecin concentrations were detected for 4 days in white bamboo sharks and for 14 days in Atlantic horseshoe crabs. No adverse effects associated with cefovecin administration were seen in either species.
authors.forename: James C
authors.initials: JC
authors.lastname: Steeil
authors.forename: Juergen
authors.initials: J
authors.lastname: Schumacher
authors.forename: Robert H
authors.initials: RH
authors.lastname: George
authors.forename: Frank
authors.initials: F
authors.lastname: Bulman
authors.forename: Katherine
authors.initials: K
authors.lastname: Baine
authors.forename: Sherry
authors.initials: S
authors.lastname: Cox
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*; D002511:Cephalosporins / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*; D006207:Half-Life; D006737:Horseshoe Crabs / Q000378:metabolism*; D011485:Protein Binding; D012754:Sharks / Q000097:blood / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; C516253:cefovecin