title: Thyroid hormone levels and incident chronic kidney disease in euthyroid individuals: the Kangbuk Samsung Health Study.
abstract: BACKGROUND
  Overt and subclinical hypothyroidism are associated with higher levels of serum creatinine and with increased risk of chronic kidney disease (CKD). The prospective association between thyroid hormones and kidney function in euthyroid individuals,however, is largely unexplored.
  
  
  METHODS
  We conducted a prospective cohort study in 104 633 South Korean men and women who were free of CKD and proteinuria at baseline and had normal thyroid hormone levels and no history of thyroid disease or cancer. At each annual or biennial follow-up visit, thyroid-stimulating hormone (TSH), free triiodothyronine (FT3) and free thyroxin (FT4) levels were measured by radioimmunoassay. The study outcome was incident CKD, defined as an estimated glomerular filtration rate (eGFR)<60 ml/min/1.73 m2 based on the Chronic Kidney Disease Epidemiology Collaboration creatinine equation.
  
  
  RESULTS
  After a median follow-up of 3.5 years, 1032 participants developed incident CKD.There was a positive association between high-normal levels of TSH and increased risk of incident CKD. In fully-adjusted models including baseline eGFR, the hazard ratio comparing the highest vs the lowest quintiles of TSH was 1.26 [95% confidence interval (CI) 1.02 to 1.55; P for linear trend=0.03]. In spline models, FT3 levels below 3 pg/ml were also associated with increased risk of incident CKD. There was no association between FT4 levels and CKD.
  
  
  CONCLUSIONS
  In a large cohort of euthyroid men and women, high levels of TSH and low levels of FT3, even within the normal range, were modestly associated with an increased risk of incident CKD.
authors.forename: Yiyi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yoosoo
authors.initials: Y
authors.lastname: Chang
authors.forename: Seungho
authors.initials: S
authors.lastname: Ryu
authors.forename: Juhee
authors.initials: J
authors.lastname: Cho
authors.forename: Won-Young
authors.initials: WY
authors.lastname: Lee
authors.forename: Eun-Jung
authors.initials: EJ
authors.lastname: Rhee
authors.forename: Min-Jung
authors.initials: MJ
authors.lastname: Kwon
authors.forename: Roberto
authors.initials: R
authors.lastname: Pastor-Barriuso
authors.forename: Sanjay
authors.initials: S
authors.lastname: Rampal
authors.forename: Won Kon
authors.initials: WK
authors.lastname: Han
authors.forename: Hocheol
authors.initials: H
authors.lastname: Shin
authors.forename: Eliseo
authors.initials: E
authors.lastname: Guallar
mesh_terms: D000328:Adult; D000368:Aged; D003404:Creatinine / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006044:Goiter, Nodular / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D056910:Republic of Korea / Q000453:epidemiology; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000378:metabolism*; D013963:Thyroid Hormones / Q000097:blood*; D013972:Thyrotropin / Q000032:analysis; D013974:Thyroxine / Q000032:analysis; D013997:Time Factors
chemical_list: D013963:Thyroid Hormones; D013972:Thyrotropin; D003404:Creatinine; D013974:Thyroxine