title: Compounds from the aerial parts of Piper bavinum and their anti-cholinesterase activity.
abstract: A new alkenylphenol, bavinol A (1), together with six known compounds (2-7) were isolated from the aerial parts of Piper bavinum (Piperaceae). The chemical structures of these compounds were determined by spectroscopic analyses including 2D NMR spectroscopy. The anti-Alzheimer effects of compounds 1-7 were evaluated from acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity assays. Bavinol A (1), ampelopsin (3), and violanthin (4) exhibited AChE inhibitory activities with IC50 values of 29.80, 59.47 and 79.80 μM. Compound 1 also showed the most potent BChE inhibitory activity with an IC50 value of 19.25 μM.
authors.affiliation: Centre of Pharmaceutical Research-Training, Vietnam Military Medical University, 160 Phung Hung, Hadong, Hanoi, Vietnam.
authors.forename: Hoang Viet
authors.initials: HV
authors.lastname: Dung
authors.forename: To Dao
authors.initials: TD
authors.lastname: Cuong
authors.forename: Nguyen Minh
authors.initials: NM
authors.lastname: Chinh
authors.forename: Do
authors.initials: D
authors.lastname: Quyen
authors.forename: Jeong Ah
authors.initials: JA
authors.lastname: Kim
authors.forename: Jeong Su
authors.initials: JS
authors.lastname: Byeon
authors.forename: Mi Hee
authors.initials: MH
authors.lastname: Woo
authors.forename: Jae Sui
authors.initials: JS
authors.lastname: Choi
authors.forename: Byung Sun
authors.initials: BS
authors.lastname: Min
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D002091:Butyrylcholinesterase / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D031701:Piper; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D002800:Cholinesterase Inhibitors; D010936:Plant Extracts; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase