title: Microbial-catalyzed biotransformation of multifunctional triterpenoids derived from phytonutrients.
abstract: Microbial-catalyzed biotransformations have considerable potential for the generation of an enormous variety of structurally diversified organic compounds, especially natural products with complex structures like triterpenoids. They offer efficient and economical ways to produce semi-synthetic analogues and novel lead molecules. Microorganisms such as bacteria and fungi could catalyze chemo-, regio- and stereospecific hydroxylations of diverse triterpenoid substrates that are extremely difficult to produce by chemical routes. During recent years, considerable research has been performed on the microbial transformation of bioactive triterpenoids, in order to obtain biologically active molecules with diverse structures features. This article reviews the microbial modifications of tetranortriterpenoids, tetracyclic triterpenoids and pentacyclic triterpenoids.
authors.affiliation: Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia. syedadnan@salam.uitm.edu.my.
authors.forename: Syed Adnan Ali
authors.initials: SA
authors.lastname: Shah
authors.affiliation: Faculty of Chemical Engineering, Universiti Teknologi MARA (UiTM), 40450 Shah Alam, Selangor Darul Ehsan, Malaysia. hueyling@salam.uitm.edu.my.
authors.forename: Huey Ling
authors.initials: HL
authors.lastname: Tan
authors.affiliation: Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia. drsadia@puncakalam.uitm.edu.my.
authors.forename: Sadia
authors.initials: S
authors.lastname: Sultan
authors.affiliation: Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia. fifa200208@gmail.com.
authors.forename: Muhammad Afifi Bin Mohd
authors.initials: MA
authors.lastname: Faridz
authors.affiliation: Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia. benzene301@gmail.com.
authors.forename: Mohamad Azlan Bin Mohd
authors.initials: MA
authors.lastname: Shah
authors.affiliation: Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia. sharifahnurfazilah@hotmail.com.
authors.forename: Sharifah
authors.initials: S
authors.lastname: Nurfazilah
authors.affiliation: Department of Basic Sciences, DHA Suffa University, Off, Khayaban-e-Tufail, Phase VII (Extension), DHA, Karachi 75500, Pakistan. mhhej@yahoo.co.in.
authors.forename: Munawar
authors.initials: M
authors.lastname: Hussain
mesh_terms: D001419:Bacteria / Q000378:metabolism; D001711:Biotransformation; D018556:Crops, Agricultural / Q000737:chemistry; D005658:Fungi / Q000378:metabolism; D036701:Limonins / Q000378:metabolism; D014315:Triterpenes / Q000378:metabolism*
chemical_list: D036701:Limonins; D014315:Triterpenes