title: Imaging, genetic testing, and biomarker assessment of follicular cell-derived thyroid cancer.
abstract: Thyroid carcinoma is the most common endocrine malignancy worldwide, and its incidence continues to increase. As such the approach to a recently identified thyroid nodule is important to understand. The relevant imaging, examination, and need for fine-needle aspiration biopsy (FNA) are discussed. In approximately 25% of nodules, the diagnosis cannot be established with FNA-based cytology, and surgical excision is necessary for definitive diagnosis. Recent advances in genetic and molecular testing may increase the diagnostic accuracy of FNA in managing thyroid nodules.
authors.affiliation: Penn State Milton S. Hershey Medical Center, Department of Surgery, Division of Otolaryngology-Head and Neck Surgery , Hershey, Pennsylvania , USA.
authors.forename: Hetal H
authors.initials: HH
authors.lastname: Patel
authors.forename: Neerav
authors.initials: N
authors.lastname: Goyal
authors.forename: David
authors.initials: D
authors.lastname: Goldenberg
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D005820:Genetic Testing; D006801:Humans; D011859:Radiography; D013961:Thyroid Gland / Q000000981:diagnostic imaging; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000235:genetics; D014463:Ultrasonography
chemical_list: D005819:Genetic Markers
keywords: BRAF; Key words:; MiRInform; RET/PTC; Ras; gene expression classifier