title: Performance of osteopontin in the diagnosis of malignant pleural mesothelioma: a meta-analysis.
abstract: It is reported that osteopontin has shown promising diagnostic value for malignant pleural mesothelioma (MPM), this meta-analysis aimed to establish the overall diagnostic accuracy of the osteopontin measurement for diagnosing MPM. Based on a systematic review of English language studies, the sensitivity, specificity and other measures of accuracy of osteopontin in the diagnosis of MPM were pooled using random-effects model. Summary receiver operating characteristic curves were used to summarize overall test performance. Seven publications met our inclusion criteria, the pooled sensitivity was 0.57 (95%CI: 0.52-0.61), specificity was 0.81, 95%CI: 0.79-0.84). The PLR was 3.78 (95%CI: 2.23-6.41), the NLR was 0.51 (95%CI: 0.38-0.67) and the DOR was 9.04 (95%CI: 5.28-15.48), the area under the summary receiver operating characteristic curve was 0.80. Our data suggest that osteopontin is likely to be a useful diagnostic marker for MPM, considering for the limited studies and patients included, larger studies are needed to confirm these findings.
authors.affiliation: Department of Rheumatology and Immunology, West China Hospital of Sichuan University Chengdu, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Lin
authors.affiliation: Department of Pulmonary Diseases, State Key Laboratory of Biotherapy of China and Department of Respiratory Medicine, West China Hospital of Sichuan University Chengdu, China.
authors.forename: Yong-Chun
authors.initials: YC
authors.lastname: Shen
authors.affiliation: Department of Pulmonary Diseases, State Key Laboratory of Biotherapy of China and Department of Respiratory Medicine, West China Hospital of Sichuan University Chengdu, China.
authors.forename: Hong-Yu
authors.initials: HY
authors.lastname: Long
authors.affiliation: Department of Pulmonary Diseases, State Key Laboratory of Biotherapy of China and Department of Respiratory Medicine, West China Hospital of Sichuan University Chengdu, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: West China School of Medicine, Sichuan University Chengdu, China.
authors.forename: Ze-Yu
authors.initials: ZY
authors.lastname: Luo
authors.affiliation: West China School of Medicine, Sichuan University Chengdu, China.
authors.forename: Zi-Xuan
authors.initials: ZX
authors.lastname: Wei
authors.affiliation: West China School of Medicine, Sichuan University Chengdu, China.
authors.forename: Shi-Qi
authors.initials: SQ
authors.lastname: Hu
authors.affiliation: Department of Pulmonary Diseases, State Key Laboratory of Biotherapy of China and Department of Respiratory Medicine, West China Hospital of Sichuan University Chengdu, China.
authors.forename: Fu-Qiang
authors.initials: FQ
authors.lastname: Wen
keywords: Osteopontin; malignant pleural mesothelioma; meta-analysis