title: Multicomponent reaction of chalcones, malononitrile and DMF leading to γ-ketoamides.
abstract: An efficient synthesis of γ-ketoamides was developed by the one-pot multicomponent reaction of chalcones, malononitrile and DMF (as both the reactant and solvent) in the presence of NaOH (3.0 equiv.). The reaction features high atom economy, easily available starting materials, operational simplicity, and good tolerance with diverse functional groups.
authors.affiliation: Department of Chemistry, Northeast Normal University, Changchun 130024, China. liangfs112@nenu.edu.cn.
authors.forename: Enxiang
authors.initials: E
authors.lastname: Wei
authors.forename: Bing
authors.initials: B
authors.lastname: Liu
authors.forename: Shaoxia
authors.initials: S
authors.lastname: Lin
authors.forename: Fushun
authors.initials: F
authors.lastname: Liang
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D047188:Chalcones / Q000737:chemistry*; D004126:Dimethylformamide / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*
chemical_list: D000577:Amides; D047188:Chalcones; D009570:Nitriles; D004126:Dimethylformamide; C000945:dicyanmethane