title: Posterior reversible encephalopathy syndrome in pediatric acute leukemia: Case series and literature review.
abstract: Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic state coupled with a unique radio imaging appearance. We describe this rare, mostly reversible condition in five cases undergoing similar treatment under preset protocol (MCP-841) for acute lymphoblastic leukemia (ALL) at our centre. Hypertension is a well-known adverse effect of high-dose corticosteroid therapy primarily mediated by its effects on the mineralocorticoid receptor especially in pediatric population and we hypothesize that this may be the etiology of PRES in two of these patients.
authors.affiliation: Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bangalore, India.
authors.forename: M Sandhya
authors.initials: MS
authors.lastname: Appachu
authors.affiliation: Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bangalore, India.
authors.forename: Samit
authors.initials: S
authors.lastname: Purohit
authors.affiliation: Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bangalore, India.
authors.forename: K C
authors.initials: KC
authors.lastname: Lakshmaiah
authors.affiliation: Department of Pediatric Oncology, Kidwai Memorial Institute of Oncology, Bangalore, India.
authors.forename: B S Aruna
authors.initials: BS
authors.lastname: Kumari
authors.affiliation: Department of Pediatric Oncology, Kidwai Memorial Institute of Oncology, Bangalore, India.
authors.forename: L
authors.initials: L
authors.lastname: Appaji
keywords: Encephalopathy syndrome; PRES; steroid induced encephalopathy