title: Computerized diagnosis of respiratory disorders. SVM based classification of VAR model parameters of respiratory sounds.
abstract: BACKGROUND
  This article is part of the Focus Theme of Methods of Information in Medicine on "Biosignal Interpretation: Advanced METHODS for Studying Cardiovascular and Respiratory Systems".
  
  
  OBJECTIVE
  This work proposes an algorithm for diagnostic classification of multi-channel respiratory sounds.
  
  
  METHODS
  14-channel respiratory sounds are modeled assuming a 250-point second order vector autoregressive (VAR) process, and the estimated model parameters are used to feed a support vector machine (SVM) classifier. Both a three-class classifier (healthy, bronchiectasis and interstitial pulmonary disease) and a binary classifier (healthy versus pathological) are considered.
  
  
  RESULTS
  In the binary scheme, the sensitivity and specificity for both classes are 85% ± 8.2%. In the three-class classification scheme, the healthy recall (95% ± 5%) and the interstitial pulmonary disease recall and precision (100% ± 0% both) are rather high. However, bronchiectasis recall is very low (30% ± 15.3%), resulting in poor healthy and bronchiectasis precision rates (76% ± 8.7% and 75% ± 25%, respectively). The main reason behind these poor rates is that the bronchiectasis is confused with the healthy case.
  
  
  CONCLUSIONS
  The proposed method is promising, nevertheless, it should be improved such that other mathematical models, additional features, and/or other classifiers are to be experimented in future studies.
authors.affiliation: Ipek Sen, Electrical and Electronics Engineering Department, Bogazici University, 34342 Bebek-Istanbul, Turkey, E-mail: ipek.sen@boun.edu.tr.
authors.forename: I
authors.initials: I
authors.lastname: Sen
authors.forename: M
authors.initials: M
authors.lastname: Saraclar
authors.forename: Y P
authors.initials: YP
authors.lastname: Kahya
mesh_terms: D001987:Bronchiectasis / Q000175:diagnosis; D003198:Computer Simulation; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D017563:Lung Diseases, Interstitial / Q000175:diagnosis; D012016:Reference Values; D012120:Respiration Disorders / Q000175:diagnosis*; D012135:Respiratory Sounds / Q000145:classification*; D060388:Support Vector Machine
keywords: Respiratory sounds; diagnostic classification; support vector machine (SVM) classifier; vector autoregressive (VAR) model