title: Synthesis, antimicrobial and anticancer evaluation of N'-(substituted benzylidene)-2-(benzo[d]oxazol-3(2H)-yl)acetohydrazide derivatives.
abstract: A series of N'-(substituted benzylidene)-2-(benzo[d]oxazol-3(2H)-yl)acetohydrazide derivatives was synthesized and evaluated for its in vitro antimicrobial and anticancer activities. Antimicrobial activity results revealed that compound 12 was found to be the most potent antimicrobial agent. Results of anticancer study indicated that the synthesized compounds exhibited average anticancer potential. Compound 7 (IC 50 =3.12 µM) and compound 16 (IC 50 =2.88 µM) were found to be most potent against breast cancer (MCF7) cell lines. In conclusion, compound 12 and 16 have the potential to be selected as lead compound for the developing of novel antimicrobial and anticancer agents respectively.
authors.affiliation: Department of Pharmaceutical Chemistry, Hindu College of Pharmacy, Sonepat, India.
authors.forename: P
authors.initials: P
authors.lastname: Rohilla
authors.affiliation: Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, India.
authors.forename: A
authors.initials: A
authors.lastname: Deep
authors.affiliation: Department of Pharmaceutical Chemistry, Hindu College of Pharmacy, Sonepat, India.
authors.forename: M
authors.initials: M
authors.lastname: Kamra
authors.affiliation: Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, India.
authors.forename: B
authors.initials: B
authors.lastname: Narasimhan
authors.affiliation: Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), 42300 Bandar Puncak Alam, Selangor, Malaysia.
authors.forename: K
authors.initials: K
authors.lastname: Ramasamy
authors.affiliation: Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), 42300 Bandar Puncak Alam, Selangor, Malaysia.
authors.forename: V
authors.initials: V
authors.lastname: Mani
authors.affiliation: Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), 42300 Bandar Puncak Alam, Selangor, Malaysia.
authors.forename: R K
authors.initials: RK
authors.lastname: Mishra
authors.affiliation: Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), 42300 Bandar Puncak Alam, Selangor, Malaysia.
authors.forename: S M
authors.initials: SM
authors.lastname: Lim
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects / Q000254:growth & development; D001597:Benzylidene Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects / Q000254:growth & development; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D001597:Benzylidene Compounds