title: A 12-week clinical study assessing the clinical effects on plaque metabolism of a dentifrice containing 1.5% arginine, an insoluble calcium compound and 1,450 ppm fluoride.
abstract: OBJECTIVE
  To evaluate the clinical effect on plaque metabolism of a dentifrice containing 1.5% arginine, an insoluble calcium compound and 1,450 ppm fluoride compared to a commercially available dentifrice containing 1,450 ppm fluoride in a silica base.
  
  
  METHODS
  A 12-week, parallel, randomized, double-blind study using 48 subjects was conducted at the Colgate-Palmolive Technology Center (Piscataway, NJ, USA). One group used a test dentifrice containing 1.5% arginine, an insoluble calcium compound and 1,450 ppm fluoride as sodium monofluorophosphate (MFP), and the other group used a commercial silica dentifrice with 1,450 ppm fluoride as sodium fluoride (NaF) as a control. Plaque metabolism analyses were conducted at baseline and after 2, 4, 6, 8, and 12 weeks of assigned product use. The plaque analyses included pH measurements before and after a sucrose rinse, ammonia production and lactic acid production.
  
  
  RESULTS
  Subjects using the test dentifrice had significantly higher plaque pH values before (P< or = 0.01) and after (P< or = 0.045) a sucrose challenge than those using the commercially available control dentifrice. Subjects using the test dentifrice also produced higher levels of ammonia and lower levels of lactic acid compared to subjects using the control dentifrice.
authors.forename: R Peter
authors.initials: RP
authors.lastname: Santarpia
authors.forename: Stacey
authors.initials: S
authors.lastname: Lavender
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Gittins
authors.forename: Mark
authors.initials: M
authors.lastname: Vandeven
authors.forename: Diane
authors.initials: D
authors.lastname: Cummins
authors.forename: Richard
authors.initials: R
authors.lastname: Sullivan
mesh_terms: D000328:Adult; D000641:Ammonia / Q000032:analysis; D001120:Arginine / Q000627:therapeutic use*; D002130:Calcium Phosphates / Q000627:therapeutic use*; D002326:Cariogenic Agents / Q000494:pharmacology; D002327:Cariostatic Agents / Q000627:therapeutic use; D003773:Dental Plaque / Q000737:chemistry / Q000378:metabolism*; D003802:Dentifrices / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005459:Fluorides / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D006863:Hydrogen-Ion Concentration; D019344:Lactic Acid / Q000032:analysis; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000627:therapeutic use*; D012824:Silicic Acid / Q000627:therapeutic use; D012969:Sodium Fluoride / Q000627:therapeutic use; D013395:Sucrose / Q000494:pharmacology; D014100:Toothpastes / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D002130:Calcium Phosphates; D002326:Cariogenic Agents; D002327:Cariostatic Agents; D003802:Dentifrices; D010710:Phosphates; D014100:Toothpastes; C546060:hydrated silica gel-based toothpaste; D012824:Silicic Acid; C012980:fluorophosphate; D019344:Lactic Acid; D013395:Sucrose; D000641:Ammonia; D012969:Sodium Fluoride; D001120:Arginine; C494366:calcium phosphate, dibasic, dihydrate; D005459:Fluorides