title: The role of adipose tissue immune cells in obesity and low-grade inflammation.
abstract: Adipose tissue (AT) lies at the crossroad of nutrition, metabolism, and immunity; AT inflammation was proposed as a central mechanism connecting obesity with its metabolic and vascular complications. Resident immune cells constitute the second largest AT cellular component after adipocytes and as such play important roles in the maintenance of AT homeostasis. Obesity-induced changes in their number and activity result in the activation of local and later systemic inflammatory response, marking the transition from simple adiposity to diseases such as type 2 diabetes mellitus, arterial hypertension, and ischemic heart disease. This review has focused on the various subsets of immune cells in AT and their role in the development of AT inflammation and obesity-induced insulin resistance.
authors.affiliation: Third Department of Medicine - Department of Endocrinology and MetabolismGeneral University Hospital, First Faculty of Medicine of Charles University in Prague, U nemocnice 1, 128 00 Prague 2, Czech Republic milos_mraz@yahoo.co.uk.
authors.forename: Milos
authors.initials: M
authors.lastname: Mraz
authors.affiliation: Third Department of Medicine - Department of Endocrinology and MetabolismGeneral University Hospital, First Faculty of Medicine of Charles University in Prague, U nemocnice 1, 128 00 Prague 2, Czech Republic.
authors.forename: Martin
authors.initials: M
authors.lastname: Haluzik
mesh_terms: D000273:Adipose Tissue / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D000818:Animals; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D007333:Insulin Resistance / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology / Q000473:pathology; D022423:Myeloid Cells / Q000276:immunology / Q000473:pathology; D009765:Obesity / Q000209:etiology / Q000276:immunology* / Q000473:pathology
keywords: adaptive immunity; adipose tissue; immune cells; innate immunity; insulin resistance; low-grade inflammation