title: Use of nonsteroidal anti-inflammatory drugs and reduced breast cancer risk among overweight women.
abstract: Chronic inflammation is associated with increased risk of multiple cancers, including breast cancer. Adipose tissues produce proinflammatory cytokines, and obesity is a risk factor for postmenopausal breast cancer. We evaluated the association of regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) with breast cancer risk, overall and by body mass index (BMI) and tumor subtypes defined by estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 status. We conducted a population-based, case-control study involving 5,078 women aged 25-75 years who were recruited primarily from the Nashville metropolitan area of Tennessee. Multivariate unconditional logistic regression models were used to estimate odds ratios and 95 % confidence intervals for breast cancer risk after adjusting for multiple potential confounding factors. Regular use of any NSAID was associated with significantly reduced breast cancer risk (OR 0.78; 95 % CI 0.69-0.89). This association was observed for regular use of baby aspirin only (OR 0.82, 95 % CI 0.69-0.99), other NSAIDs only (OR 0.81, 95 % CI 0.69-0.95), and both baby aspirin and other NSAIDs (OR 0.52, 95 % CI 0.40-0.69). These significant inverse associations were found among overweight women (BMI ≥25 kg/m(2)) overall and by subtypes of breast cancer, but not among women with BMI <25 kg/m(2) (P for interaction = 0.023). Regular use of NSAIDs was inversely associated with breast cancer risk, particularly among overweight women. Overweight women may benefit more from the protective effects of NSAID use than normal-weight women.
authors.affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, 2525 West End Avenue, 8th floor, Nashville, TN, 37203-1738, USA.
authors.forename: Yong
authors.initials: Y
authors.lastname: Cui
authors.forename: Sandra L
authors.initials: SL
authors.lastname: Deming-Halverson
authors.forename: Martha J
authors.initials: MJ
authors.lastname: Shrubsole
authors.forename: Alicia
authors.initials: A
authors.lastname: Beeghly-Fadiel
authors.forename: Hui
authors.initials: H
authors.lastname: Cai
authors.forename: Alecia M
authors.initials: AM
authors.lastname: Fair
authors.forename: Xiao-Ou
authors.initials: XO
authors.lastname: Shu
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
mesh_terms: D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology; D016017:Odds Ratio; D050177:Overweight / Q000453:epidemiology*; D011159:Population Surveillance; D012042:Registries; D012306:Risk; D012307:Risk Factors; D013714:Tennessee / Q000453:epidemiology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal