title: Association between single nucleotide polymorphisms of DOT1L gene and risk of knee osteoarthritis in a Chinese Han population.
abstract: To investigate associations between single nucleotide polymorphisms rs12982744 and rs12459350 in the DOT1L gene and knee osteoarthritis (OA) susceptibility in a Chinese Han population. DOT1L rs12982744 and rs12459350 polymorphisms were genotyped in patients with knee OA and age- and sex-matched OA-free controls from a Chinese Han population. A total of 605 patients with knee OA and 615 controls were enrolled in the study. GC and CC genotypes of rs12982744, and variant C, were associated with a significantly increased risk of knee OA. On stratification analysis, the association between the risk of OA and rs12982744 GC heterozygotes compared with GG homozygotes was stronger in females and those aged >65 years. In contrast, the GA and AA genotypes of rs12459350 were not significantly associated with the risk of knee OA, even after further stratification analysis according to age or sex. Our results showed that DOT1L rs12982744 G to C change and variant C genotype may contribute to knee OA risk in a Chinese Han population.
authors.affiliation: Department of Emergency, The First Affiliated Hospital, Zhengzhou University, NO. 1 Jianshe East Road, Zhengzhou, 450052, People's Republic of China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhou
authors.forename: Fanggang
authors.initials: F
authors.lastname: Bi
authors.forename: Guohui
authors.initials: G
authors.lastname: Yang
authors.forename: Juwu
authors.initials: J
authors.lastname: Chen
mesh_terms: D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D015992:Body Mass Index; D016022:Case-Control Studies; D002681:China; D005260:Female; D005838:Genotype; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008780:Methyltransferases / Q000235:genetics*; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D012306:Risk
chemical_list: C473477:DOT1L protein, human; D008780:Methyltransferases; D011495:Histone-Lysine N-Methyltransferase