title: Malignant peritoneal mesothelioma in a child: chemotherapy with gemcitabine and platinum was effective for the disease unresponsive to other treatments.
abstract: Malignant peritoneal mesothelioma in children is a very rare disease and has a poor prognosis. Unlike malignant mesothelioma in adults, there is no clear causal association between this very rare malignancy in children and asbestos exposure. We report a case of peritoneal mesothelioma in an 11-year-old boy who presented with ascites. He was diagnosed with malignant mesothelioma on the basis of histopathological findings. His disease showed resistance to pemetrexed, but was treated successfully with platinum-based therapy with gemcitabine. He has achieved long-term survival in partial remission with stable disease.
authors.affiliation: aDepartment of Pediatrics, Fukushima Medical University School of Medicine bDivision of Pediatric Oncology, Fukushima Medical University Hospital Cancer Center, Fukushima, Japan.
authors.forename: Shogo
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Tomoko
authors.initials: T
authors.lastname: Waragai
authors.forename: Hideki
authors.initials: H
authors.lastname: Sano
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Mochizuki
authors.forename: Mitsuko
authors.initials: M
authors.lastname: Akaihata
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Ohara
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Hosoya
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kikuta
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001201:Ascites / Q000188:drug therapy; D002648:Child; D002945:Cisplatin / Q000008:administration & dosage; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D019008:Drug Resistance, Neoplasm; D005971:Glutamates / Q000627:therapeutic use; D006147:Guanine / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D008654:Mesothelioma / Q000188:drug therapy*; D000086002:Mesothelioma, Malignant; D000068437:Pemetrexed; D010534:Peritoneal Neoplasms / Q000188:drug therapy*; D000093542:Gemcitabine
chemical_list: D005971:Glutamates; D000068437:Pemetrexed; D003841:Deoxycytidine; D006147:Guanine; D002945:Cisplatin; D000093542:Gemcitabine