title: Incidence and initial disease course of inflammatory bowel diseases in 2011 in Europe and Australia: results of the 2011 ECCO-EpiCom inception cohort.
abstract: OBJECTIVE
  The aim of the present study was to validate the IBD (inflammatory bowel diseases) incidence reported in the 2010 ECCO-EpiCom (European Crohn's and Colitis Organization-Epidemiological Committee) inception cohort by including a second independent inception cohort from participating centers in 2011 and an Australian center to investigate whether there is a difference in the incidence of IBD between Eastern and Western European countries and Australia.
  
  
  METHODS
  Fourteen centers from 5 Eastern and 9 Western European countries and one center from Australia participated in the ECCO-EpiCom 2011 inception cohort. Patients' data regarding disease type, socio-demographic factors, extraintestinal manifestations and therapy were entered into the Web-based EpiCom database, www.ecco-epicom.eu.
  
  
  RESULTS
  A total of 711 adult patients were diagnosed during the inclusion year 2011, 178 (25%) from Eastern, 461 (65%) from Western Europe and 72 (10%) from Australia; 259 (37%) patients were diagnosed with Crohn's disease, 380 (53%) with ulcerative colitis and 72 (10%) with IBD unclassified. The mean annual incidence rate for IBD was 11.3/100,000 in Eastern Europe, 14.0/100,000 in Western Europe and 30.3/100,000 in Australia. Significantly more patients were diagnosed with complicated disease at diagnosis in Eastern Europe compared to Western Europe (43% vs. 27%, p=0.02).
  
  
  CONCLUSIONS
  Incidence rates, disease phenotype and initial treatment characteristics in the 2011 ECCO-EpiCom cohort were not significantly different from that reported in the 2010 cohort.
authors.affiliation: Digestive Disease Centre, Medical Section, Herlev University Hospital, Copenhagen, Denmark; 1st Department of Medicine, Semmelweis University, Budapest, Hungary. Electronic address: veghzsuzsi@gmail.com.
authors.forename: Z
authors.initials: Z
authors.lastname: Vegh
authors.affiliation: Digestive Disease Centre, Medical Section, Herlev University Hospital, Copenhagen, Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Burisch
authors.affiliation: Digestive Disease Centre, Medical Section, Herlev University Hospital, Copenhagen, Denmark.
authors.forename: N
authors.initials: N
authors.lastname: Pedersen
authors.affiliation: Nicosia Private Practice, Cyprus.
authors.forename: I
authors.initials: I
authors.lastname: Kaimakliotis
authors.affiliation: IBD Centre ISCARE, Charles University, Prague, Czech Republic.
authors.forename: D
authors.initials: D
authors.lastname: Duricova
authors.affiliation: IBD Centre ISCARE, Charles University, Prague, Czech Republic.
authors.forename: M
authors.initials: M
authors.lastname: Bortlik
authors.affiliation: Department of Medicine, Amager Hospital, Amager, Denmark.
authors.forename: S
authors.initials: S
authors.lastname: Avnstrøm
authors.affiliation: Department of Medicine, Amager Hospital, Amager, Denmark.
authors.forename: K Kofod
authors.initials: KK
authors.lastname: Vinding
authors.affiliation: Medical Department, The National Hospital of the Faroe Islands, Torshavn, Faroe Islands.
authors.forename: J
authors.initials: J
authors.lastname: Olsen
authors.affiliation: Medical Department, The National Hospital of the Faroe Islands, Torshavn, Faroe Islands.
authors.forename: K R
authors.initials: KR
authors.lastname: Nielsen
authors.affiliation: 1st Division of Internal Medicine and Division of Gastroenterology, Faculty of Medicine, University of Ioannina, Ioannina, Greece.
authors.forename: K H
authors.initials: KH
authors.lastname: Katsanos
authors.affiliation: 1st Division of Internal Medicine and Division of Gastroenterology, Faculty of Medicine, University of Ioannina, Ioannina, Greece.
authors.forename: E V
authors.initials: EV
authors.lastname: Tsianos
authors.affiliation: 1st Department of Medicine, Semmelweis University, Budapest, Hungary.
authors.forename: L
authors.initials: L
authors.lastname: Lakatos
authors.affiliation: Department of Gastroenterology and Hepatology, Soroka Medical Centre and Ben-Gurion University of the Negev, Beer Sheva, Israel.
authors.forename: D
authors.initials: D
authors.lastname: Schwartz
authors.affiliation: Department of Gastroenterology and Hepatology, Soroka Medical Centre and Ben-Gurion University of the Negev, Beer Sheva, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Odes
authors.affiliation: U.O.Gastroenterologia ed Endoscopia, Ospedale Maggiore di Crema, Crema, Italy; On behalf of the EpiCom Northern Italy centre based in Crema, Cremona, Firenze, Forlì & Padova and Reggio Emilia, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Lupinacci
authors.affiliation: On behalf of the EpiCom Northern Italy centre based in Crema, Cremona, Firenze, Forlì & Padova and Reggio Emilia, Italy; U.O. Gastroenterologia ed Endoscopia Digestiva, University of Ioannina, Forlì, Italy.
authors.forename: A
authors.initials: A
authors.lastname: De Padova
authors.affiliation: Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: L
authors.initials: L
authors.lastname: Jonaitis
authors.affiliation: Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: L
authors.initials: L
authors.lastname: Kupcinskas
authors.affiliation: Department of Gastroenterology, State University of Medicine and Pharmacy, Chisinau, Republic of Moldova.
authors.forename: S
authors.initials: S
authors.lastname: Turcan
authors.affiliation: Department of Paediatric Gastroenterology, Centre of Mother and Child, Chisinau, Republic of Moldova.
authors.forename: O
authors.initials: O
authors.lastname: Tighineanu
authors.affiliation: Department of Paediatric Gastroenterology, Centre of Mother and Child, Chisinau, Republic of Moldova.
authors.forename: I
authors.initials: I
authors.lastname: Mihu
authors.affiliation: Hospital de Vale de Sousa, Porto, Portugal.
authors.forename: L F
authors.initials: LF
authors.lastname: Barros
authors.affiliation: Department of Gastroenterology, Hospital de São João, Porto, Portugal; Department of Pharmacology and Therapeutics, Oporto Medical School, Porto, Portugal; MedInUP-Centre for Drug Discovery and Innovative Medicines, University of Porto, Porto, Portugal.
authors.forename: F
authors.initials: F
authors.lastname: Magro
authors.affiliation: Clinic of Gastroenterology, University of Medicine 'Victor Babes', Timisoara, Romania.
authors.forename: D
authors.initials: D
authors.lastname: Lazar
authors.affiliation: Clinic of Gastroenterology, University of Medicine 'Victor Babes', Timisoara, Romania.
authors.forename: A
authors.initials: A
authors.lastname: Goldis
authors.affiliation: Gastroenterology Department, POVISA Hospital, Vigo, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Fernandez
authors.affiliation: Gastroenterology Department, Complexo Hospitalario Universitario de Vigo, Vigo, Spain.
authors.forename: V
authors.initials: V
authors.lastname: Hernandez
authors.affiliation: Department of Gastroenterology, St Vincent's Hospital, Melbourne, Victoria, Australia.
authors.forename: O
authors.initials: O
authors.lastname: Niewiadomski
authors.affiliation: Department of Gastroenterology, St Vincent's Hospital, Melbourne, Victoria, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Bell
authors.affiliation: Department of Medical Gastroenterology, Gentofte Hospital, Copenhagen, Denmark.
authors.forename: E
authors.initials: E
authors.lastname: Langholz
authors.affiliation: Digestive Disease Centre, Medical Section, Herlev University Hospital, Copenhagen, Denmark.
authors.forename: P
authors.initials: P
authors.lastname: Munkholm
authors.affiliation: 1st Department of Medicine, Semmelweis University, Budapest, Hungary.
authors.forename: P L
authors.initials: PL
authors.lastname: Lakatos
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001315:Australia / Q000453:epidemiology; D015331:Cohort Studies; D003093:Colitis, Ulcerative / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D003113:Colonoscopy / Q000706:statistics & numerical data; D003251:Constriction, Pathologic / Q000209:etiology; D003424:Crohn Disease / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015994:Incidence; D008297:Male; D019804:Mesalamine / Q000627:therapeutic use; D008875:Middle Aged; D012720:Severity of Illness Index; D012907:Smoking / Q000453:epidemiology; D013256:Steroids / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007166:Immunosuppressive Agents; D013256:Steroids; D019804:Mesalamine
keywords: Inception cohort; Incidence; Inflammatory bowel diseases