title: Mst3b promotes spinal cord neuronal regeneration by promoting growth cone branching out in spinal cord injury rats.
abstract: Spinal cord injury is a severe clinical problem, and research searching activity molecular that can promote spinal cord injury repairing is very prevalent. Mst3b can promote repair of damaged peripheral nerves and the optic nerve, but has been rarely reported in spinal cord injury research. Through detecting its expression in different periods of injured spinal cord, we found that the expression of Mst3b was significantly upregulated in injured spinal cord neurons. Increasing Mst3b expression using adenovirus in vivo and in vitro promoted axonal regeneration of spinal cord neurons, which led to behavioral and electrophysiological improvement. Downregulation of Mst3b level had the adverse effects. Increasing Mst3b expression in PC12 cells resulted in an elevation of P42/44(MAPK) and LIMK/Cofilin activation. These results identified Mst3b as a powerful regulator for promoting spinal cord injury recovery through the P42/44(MAPK) and LIMK/Cofilin signaling pathways.
authors.affiliation: Institute of Human Anatomy and Histology and Embryology, Otology & Neuroscience Center, Binzhou Medical University, 346 Guanhai Road, Laishan, Shandong Province, 264003, China.
authors.forename: Yuqiang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Huaiqiang
authors.initials: H
authors.lastname: Hu
authors.forename: Ting
authors.initials: T
authors.lastname: Tian
authors.forename: Luping
authors.initials: L
authors.lastname: Zhang
authors.forename: Dongmei
authors.initials: D
authors.lastname: Zhao
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Wu
authors.forename: Yingwei
authors.initials: Y
authors.lastname: Chang
authors.forename: Qingbo
authors.initials: Q
authors.lastname: Wang
authors.forename: Shuai
authors.initials: S
authors.lastname: Zhou
authors.forename: Guoying
authors.initials: G
authors.lastname: Feng
authors.forename: Fei
authors.initials: F
authors.lastname: Huang
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D005260:Female; D020439:Growth Cones / Q000378:metabolism* / Q000473:pathology; D009416:Nerve Regeneration / Q000502:physiology*; D011247:Pregnancy; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013119:Spinal Cord Injuries / Q000378:metabolism* / Q000473:pathology; D000099317:Hippo Kinases
chemical_list: D017346:Protein Serine-Threonine Kinases; C109163:STK24 protein, human; D000099317:Hippo Kinases