title: High-dose reirradiation with intensity-modulated radiotherapy for recurrent head-and-neck cancer: disease control, survival and toxicity.
abstract: OBJECTIVE
  To evaluate disease control, survival and severe late toxicity after high-dose fractionated reirradiation using intensity-modulated radiotherapy (IMRT) for recurrent head-and-neck cancer.
  
  
  METHODS
  Sixty consecutive patients were reirradiated with IMRT between 1997 and 2011. The median prescribed dose was 70 Gy in 35 daily fractions until 2004 and 69.12 Gy in 32 daily fractions thereafter. The median cumulative dose was 132 Gy. Sixty-seven percent of patients had non-metastatic stage IV disease. Surgery prior to reirradiation and concomitant systemic therapy was performed in 13 (22%) and 20 (33%) patients, respectively.
  
  
  RESULTS
  Median follow-up in living patients was 18.5 months. Actuarial 1-, 2- and 5-year locoregional control was 64%, 48% and 32%, respectively. Median overall (OS) and disease-free survival was 9.6 and 6.7 months, respectively. Actuarial 1-, 2- and 5-year OS was 44%, 32% and 22%, respectively. Seventeen (27%) and 2 (3%) patients had grade 3 and 4 acute toxicity, respectively. Cumulative incidence of late grade≥3 toxicity was 23%, 27% and 66% at 1, 2 and 5 years, respectively. In 4 patients, death was attributed to toxicity: fatal bleeding (n=2), aspiration pneumonia (n=1) and skin necrosis (n=1).
  
  
  CONCLUSIONS
  High-dose fractionated reirradiation with IMRT offers 5-year disease control and OS in recurrent head-and-neck cancer for 1/3 and 1/4 patients, respectively. Severe late toxicity after 1-2 and 5 years occurs in 1/4 and 2/3 patients, respectively.
authors.affiliation: Department of Radiotherapy. Electronic address: frederic.duprez@uzgent.be.
authors.forename: Fréderic
authors.initials: F
authors.lastname: Duprez
authors.affiliation: Department of Radiotherapy.
authors.forename: Dieter
authors.initials: D
authors.lastname: Berwouts
authors.affiliation: Department of Radiotherapy.
authors.forename: Indira
authors.initials: I
authors.lastname: Madani
authors.affiliation: Department of Head & Neck Surgery, Ghent University Hospital, Belgium.
authors.forename: Katrien
authors.initials: K
authors.lastname: Bonte
authors.affiliation: Department of Radiotherapy.
authors.forename: Tom
authors.initials: T
authors.lastname: Boterberg
authors.affiliation: Department of Radiotherapy.
authors.forename: Werner
authors.initials: W
authors.lastname: De Gersem
authors.affiliation: Department of Head & Neck Surgery, Ghent University Hospital, Belgium.
authors.forename: Philippe
authors.initials: P
authors.lastname: Deron
authors.affiliation: Department of Head & Neck Surgery, Ghent University Hospital, Belgium.
authors.forename: Wouter
authors.initials: W
authors.lastname: Huvenne
authors.affiliation: Department of Radiotherapy.
authors.forename: Wilfried
authors.initials: W
authors.lastname: De Neve
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy*; D018572:Disease-Free Survival; D005260:Female; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects / Q000379:methods; D000077195:Squamous Cell Carcinoma of Head and Neck; D015996:Survival Rate; D016896:Treatment Outcome
keywords: Head-and-neck cancer; IMRT; Radiotherapy; Reirradiation; Toxicity