title: Oral contraceptives in polycystic ovary syndrome.
abstract: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder of women of reproductive age and combined oral contraceptives (OCs) are often the first-line treatment of the syndrome by improving hyperandrogenism and regulating menstrual cycles. Oral contraceptives have some cardiovascular and metabolic effects that varies among different formulations depending upon the dose and type of the both estrogen and progestin components. These cardiometabolic effects of OCs raise some concerns about their long-term use in PCOS, but available data suggest that the benefits outweigh the risks. More studies are needed to clarify the safety of long-term use of OCs in PCOS.
authors.affiliation: Division of Endocrinology and Metabolism Department of Internal Medicine Hacettepe University School of Medicine Hacettepe, Ankara, Turkey - yildizbo@yahoo.com.
authors.forename: N
authors.initials: N
authors.lastname: Helvaci
authors.forename: B O
authors.initials: BO
authors.lastname: Yildiz
mesh_terms: D001157:Arterial Occlusive Diseases / Q000139:chemically induced; D001943:Breast Neoplasms / Q000139:chemically induced; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D000075202:Contraindications; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000188:drug therapy / Q000209:etiology; D007333:Insulin Resistance; D015201:Meta-Analysis as Topic; D015394:Molecular Structure; D009026:Mortality; D009203:Myocardial Infarction / Q000139:chemically induced; D010051:Ovarian Neoplasms / Q000517:prevention & control; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000188:drug therapy*; D020521:Stroke / Q000139:chemically induced; D019851:Thrombophilia / Q000139:chemically induced*; D013927:Thrombosis / Q000139:chemically induced; D054556:Venous Thromboembolism / Q000139:chemically induced
chemical_list: D003277:Contraceptives, Oral, Combined