title: Adalimumab for Crohn's disease in New Zealand--a prospective multicentre experience.
abstract: OBJECTIVE
  Adalimumab is an effective treatment for Crohn's disease (CD). We aimed to describe the early patterns of use, efficacy and response to adalimumab in four regions of New Zealand.
  
  
  METHODS
  Prospectively collected CDAI data were used to examine adalimumab continuation rates in CD patients. Reasons for adalimumab cessation were determined and phenotypic characteristics of those remaining on adalimumab were examined.
  
  
  RESULTS
  194 patients (100 female) from four centres were included. Indications for adalimumab included CDAI>300 (59.8%), extensive small intestinal disease (21.1%), stoma with active disease (4.6%), risk of short gut syndrome (7.7%) and other (6.7%). The mean follow-up was 20 months (252.8 patient years of data). Adalimumab continuation rates at 6, 12, 24 and 30 months were 92.7%, 87.3%, 76.6% and 67.4%, respectively. Patients with penetrating disease behaviour were more likely to continue on adalimumab (p<0.005). There was a significant reduction in mean CDAI from 357 to 110 (p<0.0001) over a 6-month period. The mean (range) number of days spent in hospital per patient in the year prior and after adalimumab initiation were 3.5 (0-38) days and 1.9 (0-67) days, respectively (p<0.0001).
  
  
  CONCLUSIONS
  Adalimumab continuation rate in this multicentre CD population was higher than other populations. This may be due to adalimumab being used more commonly as the initial biologic drug in New Zealand.
authors.forename: Gareth R
authors.initials: GR
authors.lastname: Thomas
authors.forename: Timothy
authors.initials: T
authors.lastname: Lewis-Morris
authors.forename: David
authors.initials: D
authors.lastname: Rowbotham
authors.forename: Cathryn
authors.initials: C
authors.lastname: Whiteside
authors.forename: Stephne
authors.initials: S
authors.lastname: Joyce
authors.forename: Stephen
authors.initials: S
authors.lastname: Inns
authors.forename: Michael
authors.initials: M
authors.lastname: Schultz
authors.affiliation: Department of Medicine, University of Otago - Christchurch, PO Box 4345, Christchurch 8140, New Zealand. Richard.gearry@cdhb.govt.nz.
authors.forename: Richard B
authors.initials: RB
authors.lastname: Gearry
mesh_terms: D000068879:Adalimumab; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized / Q000009:adverse effects / Q000627:therapeutic use*; D003424:Crohn Disease / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D055118:Medication Adherence; D009520:New Zealand; D010502:Perineum; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D061067:Antibodies, Monoclonal, Humanized; D000068879:Adalimumab