title: Heterochrony and developmental timing mechanisms: changing ontogenies in evolution.
abstract: Heterochrony, or a change in developmental timing, is an important mechanism of evolutionary change. Historically the concept of heterochrony has focused alternatively on changes in size and shape or changes in developmental sequence, but most have focused on the pattern of change. Few studies have examined changes in the mechanisms that embryos use to actually measure time during development. Recently, evolutionary studies focused on changes in distinct timekeeping mechanisms have appeared, and this review examines two such case studies: the evolution of increased segment number in snakes and the extreme rostral to caudal gradient of developmental maturation in marsupials. In both examples, heterochronic modifications of the somite clock have been important drivers of evolutionary change.
authors.affiliation: Department of Pediatrics, Duke University Medical Center, Durham, NC, United States.
authors.forename: Anna L
authors.initials: AL
authors.lastname: Keyte
authors.affiliation: Department of Biology, Duke University, Durham, NC, United States. Electronic address: kksmith@duke.edu.
authors.forename: Kathleen K
authors.initials: KK
authors.lastname: Smith
mesh_terms: D000818:Animals; D005075:Biological Evolution; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D009024:Morphogenesis; D019170:Somites / Q000502:physiology
keywords: Developmental timing; Heterochrony; Limb; Marsupial; Somitogenesis; Timekeeping mechanisms