title: Carotenoderma in a young woman of normal body mass index with hypothalamic amenorrhoea: a 2-year follow-up case report.
abstract: Hypothalamic amenorrhoea has been shown to be associated with hypercarotenaemia, but no causal link has been established. Many people are unaware of the health implications of carotenoderma. We report on a 36-year-old woman with normal body mass index and with a history of secondary amenorrhoea for 2 years and carotenoderma for 5 years. She had a history of practising a fixed-menu diet of predominantly leafy greens, exercised intensively and had a stressful job. Blood tests confirmed the presence of hypercarotenaemia and hypogonadotrophic hypogonadism. Carotenoderma subsided after 6 months of lifestyle modification, but she remained amenorrhoeic up to 12 months later. Since then, her condition had relapsed up to the time of 2 years of follow-up. We conclude that hypercarotenaemia/carotenoderma and hypothalamic amenorrhoea are manifestations of a constrained lifestyle rather than causally linked. The presence of carotenoderma should alert public individuals and clinicians, especially in primary care, alike for signs of potential health complications including reproductive dysfunction even without weight problems.
authors.affiliation: Department of Diabetes and Endocrinology, Ashford and St Peter's NHS Foundation Trust, Chertsey, UK.
authors.forename: M
authors.initials: M
authors.lastname: Nyekiova
authors.affiliation: Department of Diabetes and Endocrinology, Ashford and St Peter's NHS Foundation Trust, Chertsey, UK.
authors.forename: S
authors.initials: S
authors.lastname: Ghaderi
authors.affiliation: Department of Diabetes and Endocrinology, Ashford and St Peter's NHS Foundation Trust, Chertsey, UK.
authors.forename: T S
authors.initials: TS
authors.lastname: Han
mesh_terms: D000328:Adult; D000568:Amenorrhea / Q000150:complications* / Q000209:etiology; D002338:Carotenoids / Q000009:adverse effects; D005260:Female; D006801:Humans; D007006:Hypogonadism / Q000150:complications* / Q000209:etiology; D008019:Life Style; D012871:Skin Diseases / Q000150:complications* / Q000209:etiology
chemical_list: D002338:Carotenoids