title: Mitochondrial D310 instability in Chinese lung cancer patients.
abstract: To characterize the somatic mutation spectrum of mitochondrial DNA at D310 in Chinese lung cancer patients and evaluate its potential significance in Chinese lung cancer diagnosis, in this study, 237 samples, including lung tumor, adjacent normal tissue and blood samples of 79 lung cancer patients were analyzed. By comparing sequences of D310 between lung cancer tissues, adjacent normal tissue and blood samples, the somatic mutations at D310 were detected in 17.72% (14/79) of Chinese lung cancer patients; this implied that somatic mutations at D310 could be served as valuable biomarker for diagnostic of Chinese lung cancer. Further analyses indicated that deletion and heterogeneity were the predominant characters for somatic mutations detected at D310 of Chinese lung cancer patients.
authors.affiliation: a Department of ICU , The Second People's Hospital of Yunnan Province , Kunming , Yunnan Province , China .
authors.forename: Xian-Zhong
authors.initials: XZ
authors.lastname: Chen
authors.affiliation: b Department of Anesthesiology , the first affiliated hospital of Kunming Medical University , Kunming , Yunnan Province , China .
authors.forename: Yu
authors.initials: Y
authors.lastname: Fang
authors.affiliation: c Department of Clinical Laboratory , Shanxi Tumor Hospital , Taiyuan , Shanxi , China .
authors.forename: Yan-Hai
authors.initials: YH
authors.lastname: Shi
authors.affiliation: d Department of Medical Service , Unit 65176 of PLA , Dalian , Liaoning , China , and.
authors.forename: Jing-Hui
authors.initials: JH
authors.lastname: Cui
authors.affiliation: e Department of Cardiology and Clinical Laboratory , 211 Hospital of PLA , Harbin , Heilongjiang , China.
authors.forename: Long-Yan
authors.initials: LY
authors.lastname: Li
authors.affiliation: e Department of Cardiology and Clinical Laboratory , 211 Hospital of PLA , Harbin , Heilongjiang , China.
authors.forename: Yong-Chen
authors.initials: YC
authors.lastname: Xu
authors.affiliation: a Department of ICU , The Second People's Hospital of Yunnan Province , Kunming , Yunnan Province , China .
authors.forename: Bin
authors.initials: B
authors.lastname: Ling
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D004272:DNA, Mitochondrial / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics*; D005260:Female; D042822:Genomic Instability; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D009154:Mutation
chemical_list: D014408:Biomarkers, Tumor; D004272:DNA, Mitochondrial; D004273:DNA, Neoplasm
keywords: Chinese; D310 mutation; lung cancer; mitochondrial DNA