title: Polymeric supra-amphiphiles based on terminal group electrostatic interactions: fabrication of micelles with modifiable surfaces.
abstract: On the basis of terminal group electrostatic interactions (TGEI), a supra-amphiphile is formed between a homopolymer of polylactic acid with carboxyl group at one end (PLA-COOH) and hepta-6-hydrazyl-β-cyclodextrin (HH-CD). The amphiphile can self-assemble into a micellar structure in aqueous solution. The outer surface of the micelle, which is composed of cyclodextrins, can be further modified via host-guest interactions. Considering the biocompatibility of the building blocks, the application of the micelles in a nanocarrier of anticancer drugs is further explored.
authors.affiliation: Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Beijing 100190, P.R. China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Liu
authors.forename: Jing
authors.initials: J
authors.lastname: Qiao
authors.forename: Ye
authors.initials: Y
authors.lastname: Tian
authors.forename: Man
authors.initials: M
authors.lastname: Wu
authors.forename: Zhongwei
authors.initials: Z
authors.lastname: Niu
authors.forename: Yong
authors.initials: Y
authors.lastname: Huang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D001692:Biological Transport; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism; D004339:Drug Compounding; D065546:Drug Liberation; D006367:HeLa Cells; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry*; D008823:Micelles; D015394:Molecular Structure; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D012996:Solutions; D055672:Static Electricity; D013499:Surface Properties; D013501:Surface-Active Agents / Q000737:chemistry*; D014867:Water; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D008823:Micelles; D011091:Polyesters; D011108:Polymers; D012996:Solutions; D013501:Surface-Active Agents; D047392:beta-Cyclodextrins; D014867:Water; D019344:Lactic Acid; C033616:poly(lactide); D004317:Doxorubicin