title: Lack of association between the matrix metalloproteinase-2 -1306C>T polymorphism and breast cancer susceptibility: a meta-analysis.
abstract: BACKGROUND
  Since inconsistent results have been reported regarding the relation between the matrix metalloproteinase-2 (MMP-2) -1306C>T polymorphism and susceptibility for breast cancer, we performed a meta-analysis to investigate the issue.
  
  
  METHODS
  An internet search of PubMed and EMBASE was performed to identify eligible studies. Pooled odds ratios (ORs) with their corresponding confidence intervals (CIs) were calculated to evaluate any association between MMP-2 -1306C>T polymorphism and breast cancer susceptibility.
  
  
  RESULTS
  Nine case-control studies were included in the meta-analysis, involving 9,858 cases and 10,871 controls. Overall, there was no evidence of any association between the MMP-2 -1306C>T polymorphism and breast cancer susceptibility in different genetic models (T-allele vs C-allele: OR=0.95, 95%CI, 0.82-1.10, p=0.49; TT vs CC: OR=1.03, 95%CI, 0.90-1.19, p=0.66; TT+TC vs CC: OR=0.93, 95%CI, 0.78-1.10, p=0.38; TT vs TC+CC: OR=1.02, 95%CI, 0.89-1.17, p=0.77). In the subgroup analysis by ethnicity, CC was associated with a significant increase in breast susceptibility among Latin-Americans in the dominant model (OR=0.61, 95%CI, 0.40-0.93, p=0.02), but the association disappeared in other models. No significant association was observed among Europeans, East Asians and others in different genetic models. In the subgroup analysis by their source of controls, no significant association between MMP-2 -1306C>T polymorphism and breast cancer susceptibility was noted among population-based studies and hospital-based studies in different genetic models.
  
  
  CONCLUSIONS
  The results of this meta-analysis suggest that MMP-2 -1306C>T polymorphism is not associated with breast cancer susceptibility, although the association among Latin-Americans in the dominant model was significant.
authors.affiliation: Department of Breast Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China E-mail : xiexm@sysucc.org.cn.
authors.forename: Lu
authors.initials: L
authors.lastname: Yang
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.forename: Siyu
authors.initials: S
authors.lastname: Wang
authors.forename: Yanan
authors.initials: Y
authors.lastname: Kong
authors.forename: Hailin
authors.initials: H
authors.lastname: Tang
authors.forename: Xinhua
authors.initials: X
authors.lastname: Xie
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Xie
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis
chemical_list: C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2