title: Allogeneic stem cell transplantation for Philadelphia chromosome-positive acute myeloid leukemia.
abstract: Philadelphia chromosome-positive acute myeloid leukemia (Ph(+)-AML) has a poor response to anthracycline- and cytarabine-containing regimens, high relapse rate, and dismal prognosis. Although therapy with imatinib and allogeneic stem cell transplantation (allo-SCT) is promising, relatively short follow-up limits understanding of long-term results of these therapies. This report describes the outcomes of 3 cases of Ph(+)-AML diagnosed and transplanted at the University of Nebraska Medical Center between 2004 and 2011. These patients, young and without major comorbidities, received induction therapy with 7 days of cytarabine and 3 days of idarubicin along with imatinib and consolidation therapy with high-dose cytarabine (with or without imatinib). All patients underwent 10/10 HLA-matched peripheral blood allo-SCT (sibling donor for first and third patients and unrelated donor for the second patient; all had acute graft-versus-host disease (GVHD), and the first and third patients had chronic GVHD. All patients are currently alive and experiencing complete remission at 116, 113, and 28 months after diagnosis, respectively. This report shows that the use of allo-SCT with resultant graft-versus-leukemia effect and the addition of imatinib can result in long-term remission and possible cure in some patients with Ph(+)-AML.
authors.affiliation: From the Department of Internal Medicine, Division of Hematology-Oncology; Human Genetics Laboratory, Munroe Meyer Institute for Genetics and Rehabilitation; and Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska.
authors.forename: Vijaya Raj
authors.initials: VR
authors.lastname: Bhatt
authors.affiliation: From the Department of Internal Medicine, Division of Hematology-Oncology; Human Genetics Laboratory, Munroe Meyer Institute for Genetics and Rehabilitation; and Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska.
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Akhtari
authors.affiliation: From the Department of Internal Medicine, Division of Hematology-Oncology; Human Genetics Laboratory, Munroe Meyer Institute for Genetics and Rehabilitation; and Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska.
authors.forename: R Gregory
authors.initials: RG
authors.lastname: Bociek
authors.affiliation: From the Department of Internal Medicine, Division of Hematology-Oncology; Human Genetics Laboratory, Munroe Meyer Institute for Genetics and Rehabilitation; and Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska.
authors.forename: Jennifer N
authors.initials: JN
authors.lastname: Sanmann
authors.affiliation: From the Department of Internal Medicine, Division of Hematology-Oncology; Human Genetics Laboratory, Munroe Meyer Institute for Genetics and Rehabilitation; and Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska.
authors.forename: Ji
authors.initials: J
authors.lastname: Yuan
authors.affiliation: From the Department of Internal Medicine, Division of Hematology-Oncology; Human Genetics Laboratory, Munroe Meyer Institute for Genetics and Rehabilitation; and Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska.
authors.forename: Bhavana J
authors.initials: BJ
authors.lastname: Dave
authors.affiliation: From the Department of Internal Medicine, Division of Hematology-Oncology; Human Genetics Laboratory, Munroe Meyer Institute for Genetics and Rehabilitation; and Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska.
authors.forename: Warren G
authors.initials: WG
authors.lastname: Sanger
authors.affiliation: From the Department of Internal Medicine, Division of Hematology-Oncology; Human Genetics Laboratory, Munroe Meyer Institute for Genetics and Rehabilitation; and Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska.
authors.forename: Anne
authors.initials: A
authors.lastname: Kessinger
authors.affiliation: From the Department of Internal Medicine, Division of Hematology-Oncology; Human Genetics Laboratory, Munroe Meyer Institute for Genetics and Rehabilitation; and Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska.
authors.forename: James O
authors.initials: JO
authors.lastname: Armitage
mesh_terms: D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D001549:Benzamides / Q000627:therapeutic use; D060830:Consolidation Chemotherapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D003561:Cytarabine / Q000627:therapeutic use; D005260:Female; D006086:Graft vs Host Disease / Q000188:drug therapy; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015255:Idarubicin / Q000627:therapeutic use; D000068877:Imatinib Mesylate; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D060828:Induction Chemotherapy; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010677:Philadelphia Chromosome; D010879:Piperazines / Q000627:therapeutic use; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D011743:Pyrimidines / Q000627:therapeutic use; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000903:Antibiotics, Antineoplastic; D000964:Antimetabolites, Antineoplastic; D001549:Benzamides; D007166:Immunosuppressive Agents; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D003561:Cytarabine; D000068877:Imatinib Mesylate; D003520:Cyclophosphamide; D015255:Idarubicin