title: Coronary plaque type and burden by computed tomography angiography without association to C-reactive protein.
abstract: BACKGROUND
  Contrast-enhanced computed tomography angiography (CTA) of the coronaries allows identification of plaques. Limited data exists on the relationship between C-reactive protein (CRP) and the plaque type or plaque burden detected by CTA.
  
  
  OBJECTIVE
  We studied relationship between CRP and coronary atherosclerosis.
  
  
  METHODS
  92 patients without history of coronary disease underwent coronary CTA for chest pain. Coronary arteries were evaluated with each detected plaque labeled as calcified, noncalcified or mixed. Logarithmic transformation was done on CRP values for statistical analysis.
  
  
  RESULTS
  1380 coronary segments were evaluated. The average age was 57 years (SE 1.0) and basal metabolic index (BMI) 28.9 kg/m2 (SE 0.5). Median CRP level was 2.75 mg/L (range 0.17-16.98). No association was found between CRP quartiles and plaque type. In stepwise multivariate analysis, only diabetes was associated with noncalcified plaque (P < 0.001). When calcified and mixed plaques were added to the model, age (P < 0.001), diabetes (P < 0.02), and statin use (P < 0.05) were associated with an increased number of plaques per subject. No association was found between log-CRP for any type of plaque.
  
  
  CONCLUSIONS
  There was no association between CRP and plaque type by CTA. Lack of association is likely due to limited spatial resolution and underestimation of noncalcified plaque burden by CTA.
authors.affiliation: Division of Cardiovascular Medicine, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.
authors.forename: Leenhapong
authors.initials: L
authors.lastname: Navaravong
authors.affiliation: Department of Radiology, University of Minnesota and Minneapolis VAMC, Minneapolis, Minnesota, USA.
authors.forename: Carol
authors.initials: C
authors.lastname: Steenson
authors.affiliation: Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
authors.forename: Gardar
authors.initials: G
authors.lastname: Sigurdsson
keywords: Atherosclerosis; CRP; CTA; Computed tomography angiography; Coronary calcium; Imaging