title: Driving glioblastoma growth by alternative polyadenylation.
abstract: Global shortening of 3' untranslated regions (3' UTRs) through alternative polyadenylation is an emerging hallmark of cancer. A recent study identifies the cleavage factor Im 25 (CFIm25) as an important mediator of 3' UTR shortening in glioblastomas and demonstrates a causal relationship between alternative polyadenylation and cancer cell proliferation.
authors.affiliation: Department of Biochemistry, UT Southwestern Medical Center, Dallas, TX 75390-9152, USA.
authors.forename: Ting
authors.initials: T
authors.lastname: Han
authors.affiliation: Life Sciences Institute, Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109-2216, USA.
authors.forename: John K
authors.initials: JK
authors.lastname: Kim
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D005909:Glioblastoma / Q000503:physiopathology*; D006801:Humans; D008297:Male; D026723:Polyadenylation; D012333:RNA, Messenger / Q000378:metabolism*; D039221:mRNA Cleavage and Polyadenylation Factors / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger; D039221:mRNA Cleavage and Polyadenylation Factors