title: The application of (-)-epigallocatechin gallate in preparation of an antioxidant dialysate.
abstract: Hemodialysis can remove uremic solutes but this treatment induces oxidative stress in uremic patients because of hemo-incompatibility. Therefore, we hypothesised that an antioxidant dialysate (a dialysate containing antioxidant(s)) would provide antioxidant defence in uremic patients during hemodialysis. Several herbal extracts were studied and measurements of antioxidant power and stability assays indicated that epigallocatechin gallate (EGCG) was the best of those tested for use as an antioxidant dialysate (EGCG dialysate). We observed that EGCG dialysate could provide the highest level of antioxidant defence at a dialysate flow rate of 500 ml/min and a blood flow rate of 200 ml/min. In addition, some important parameters for hemodialysis were calculated for supporting the protective role of EGCG dialysate. This is the first description of the preparation of an antioxidant dialysate. We suggest that EGCG dialysate will reduce the level of oxidative stress in hemodialysis patients, leading to a decrease of complications associated with oxidative damage.
authors.affiliation: Graduate Institute of Basic Medical Science, China Medical University, Taichung 404, Taiwan.
authors.forename: Tung-Sheng
authors.initials: TS
authors.lastname: Chen
authors.affiliation: Formosan Blood Purification Foundation, 50, Sec. 1, Bade Rd., Taipei, Taiwan.
authors.forename: Show-Yih
authors.initials: SY
authors.lastname: Liou
authors.affiliation: School of Medicine, China Medical University, Taichung 404, Taiwan.
authors.forename: Hsi-Chin
authors.initials: HC
authors.lastname: Wu
authors.affiliation: Department of Biomedical Engineering, Chung Yuan Christian University, 200 Chung Pei Rd., Chung Li 32023, Taiwan.
authors.forename: Miao-Lin
authors.initials: ML
authors.lastname: Wu
authors.affiliation: Graduate Institute of Chinese Medical Science, China Medical University, Taichung 404, Taiwan; Department of Pediatrics, Medical Research and Medical Genetics, China Medical University, Taichung 404, Taiwan.
authors.forename: Fuu-Jen
authors.initials: FJ
authors.lastname: Tsai
authors.affiliation: Department of Healthcare Administration, Asia University, Taichung 413, Taiwan.
authors.forename: Chang-Hai
authors.initials: CH
authors.lastname: Tsai
authors.affiliation: Graduate Institute of Basic Medical Science, China Medical University, Taichung 404, Taiwan; Graduate Institute of Chinese Medical Science, China Medical University, Taichung 404, Taiwan; Department of Health and Nutrition Biotechnology, Asia University, Taichung 413, Taiwan.
authors.forename: Chih-Yang
authors.initials: CY
authors.lastname: Huang
authors.affiliation: Department of Biomedical Engineering, Chung Yuan Christian University, 200 Chung Pei Rd., Chung Li 32023, Taiwan.
authors.forename: Yen-Lin
authors.initials: YL
authors.lastname: Chang
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology; D015312:Hemodialysis Solutions / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects*; D059808:Polyphenols / Q000032:analysis*
chemical_list: D000975:Antioxidants; D015312:Hemodialysis Solutions; D059808:Polyphenols; D002392:Catechin; C045651:epigallocatechin gallate