title: Subcutaneous ustekinumab for the treatment of anti-TNF resistant Crohn's disease--the McGill experience.
abstract: BACKGROUND
  Ustekinumab is a fully human IgG1κ monoclonal antibody that blocks the biologic activity of interleukin-12/23. Ustekinumab is approved for treatment of plaque psoriasis and has been shown to be effective for induction and maintenance of clinical response in anti-TNF resistant Crohn's disease (CD). The aim of the study was to describe the real-life experience with open-label use of ustekinumab in anti-TNF resistant CD patients.
  
  
  METHODS
  A retrospective observational open-label study. Clinical response was defined by physician's global assessment combined with decision to continue therapy. The clinical response was evaluated at 3, 6, 12months and last follow-up.
  
  
  RESULTS
  Thirty-eight patients were included in the study. Initial clinical response was achieved in 28/38 (73.7%) of the patients. Among the initial responders, 80% with follow-up data maintained their response for 6months. At 12months of follow-up, 88.9% of patients responding at 6months maintained their response. At the last follow-up (7.9±5.2 mo) 27/38 (71%) of the patients were responding, and 73.3% were able to discontinue corticosteroids. Dose escalation was required in 47.7% of the patients and was successful in 61.1% of them.
  
  
  CONCLUSIONS
  In this real-life cohort of severe anti-TNF resistant CD, an initial clinical response to subcutaneous ustekinumab was observed in 73.7% of the patients. The initial response was successfully maintained in the majority of patients for up to 12months. Subcutaneous ustekinumab is an effective therapeutic option in this challenging patient cohort. The optimal dosing and injection schedule remain to be established in future studies.
authors.affiliation: Division of Gastroenterology, McGill University Health Center, Montreal, Quebec, Canada. Electronic address: ukopylov@gmail.com.
authors.forename: U
authors.initials: U
authors.lastname: Kopylov
authors.affiliation: Division of Gastroenterology, McGill University Health Center, Montreal, Quebec, Canada.
authors.forename: W
authors.initials: W
authors.lastname: Afif
authors.affiliation: Division of Gastroenterology, Jewish General Hospital, Montreal, Quebec, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Cohen
authors.affiliation: Division of Gastroenterology, McGill University Health Center, Montreal, Quebec, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Bitton
authors.affiliation: Division of Gastroenterology, McGill University Health Center, Montreal, Quebec, Canada.
authors.forename: G
authors.initials: G
authors.lastname: Wild
authors.affiliation: Division of Gastroenterology, McGill University Health Center, Montreal, Quebec, Canada.
authors.forename: T
authors.initials: T
authors.lastname: Bessissow
authors.affiliation: Division of Gastroenterology, Jewish General Hospital, Montreal, Quebec, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Wyse
authors.affiliation: Division of Gastroenterology, McGill University Health Center, Montreal, Quebec, Canada.
authors.forename: T
authors.initials: T
authors.lastname: Al-Taweel
authors.affiliation: Division of Gastroenterology, Jewish General Hospital, Montreal, Quebec, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Szilagyi
authors.affiliation: Division of Gastroenterology, McGill University Health Center, Montreal, Quebec, Canada.
authors.forename: E
authors.initials: E
authors.lastname: Seidman
mesh_terms: D000293:Adolescent; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage*; D002170:Canada; D003424:Crohn Disease / Q000188:drug therapy*; D004351:Drug Resistance; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D008875:Middle Aged; D019233:Retreatment; D012189:Retrospective Studies; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors; D000069549:Ustekinumab; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D061067:Antibodies, Monoclonal, Humanized; D014409:Tumor Necrosis Factor-alpha; D000069549:Ustekinumab
keywords: Biologics; Crohn's disease; TNF-alpha inhibitors; Ustekinumab