title: Punctaporonins H-M: caryophyllene-type sesquiterpenoids from the sponge-associated fungus Hansfordia sinuosae.
abstract: Six new caryophyllene-based sesquiterpenoids named punctaporonins H-M (1-6), together with punctaporonin B (7) and humulane (8) were isolated from the fermentation broth of the sponge-derived fungus Hansfordia sinuosae. Their structures were determined by the extensive HRESIMS and NMR spectroscopic analysis, including the X-ray crystallographic data for the assignment of the absolute configurations of punctaporonins H-I (1-2). The isolated compounds were evaluated for antihyperlipidemic, cytotoxic and antimicrobial activities, and punctaporonin K (4) exhibited potent effects to reduce the triglycerides and total cholesterol in the intracellular levels.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China. wuzehong922@126.com.
authors.forename: Zehong
authors.initials: Z
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China. liudong_1982@126.com.
authors.forename: Dong
authors.initials: D
authors.lastname: Liu
authors.affiliation: Institute für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universität Düsseldorf, Universitätsstr. 1, Geb.26.23, 40225 Düsseldorf, Germany. Proksch@uni-duesseldorf.de.
authors.forename: Peter
authors.initials: P
authors.lastname: Proksch
authors.affiliation: Pharmacology and Toxicology Research Center, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China. pguo@implad.ac.cn.
authors.forename: Peng
authors.initials: P
authors.lastname: Guo
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China. whlin@bjmu.edu.cn.
authors.forename: Wenhan
authors.initials: W
authors.lastname: Lin
mesh_terms: D000818:Animals; D005285:Fermentation; D005658:Fungi / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D000081223:Polycyclic Sesquiterpenes; D011161:Porifera / Q000382:microbiology*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C024714:caryophyllene