title: Peyronie's disease: review and recent advances.
abstract: Peyronie's disease is an incurable, sexually debilitating fibrotic disease of the penis that results in penile curvature, coital failure, and significant psychological stress for patients and their partners. Appropriate treatment should be individualized and tailored to the patient's goals and expectations, disease history, physical exam findings, and erectile function. While medical treatments exist, there is little evidence to support their use. High-quality data supporting more recent advances in injectable therapies, interferon α-2b and collagenase clostridium histolyticum, show great promise for their application. Once the disease has stabilized, surgical correction is also an excellent option for patients with significant Peyronie's disease accompanied by functional impairment. Outcomes are satisfactory when proper treatment decisions are made, with the goal being expected return to normal sexual function following treatment.
authors.affiliation: Department of Urology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States. Electronic address: joshlangston@gmail.com.
authors.forename: Joshua P
authors.initials: JP
authors.lastname: Langston
authors.affiliation: Rhodes Distinguished Professor of Urology, Chief of Urology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
authors.forename: Culley C
authors.initials: CC
authors.lastname: Carson
mesh_terms: D007172:Erectile Dysfunction / Q000209:etiology; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D003012:Microbial Collagenase / Q000627:therapeutic use*; D010411:Penile Induration / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D010413:Penis / Q000473:pathology*; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D003012:Microbial Collagenase
keywords: Erectile dysfunction; Penile curvature; Penile plaque; Peyronie's disease