title: Dissociation of regional activity in default mode network in medication-naive, first-episode somatization disorder.
abstract: BACKGROUND
  Patients with somatization disorder (SD) have altered neural activity in the brain regions of the default mode network (DMN). However, the regional alteration of the DMN in SD remains unknown. The present study was designed to investigate the regional alterations of the DMN in patients with SD at rest.
  
  
  METHODS
  Twenty-five first-episode, medication-naive patients with SD and 28 age-, sex-, education- matched healthy controls underwent a resting-state functional magnetic resonance imaging (fMRI) scan. The fractional amplitude of low-frequency fluctuations (fALFF) was applied to analyze the data.
  
  
  RESULTS
  Patients with SD showed a dissociation pattern of resting-state fALFF in the DMN, with increased fALFF in the bilateral superior medial prefrontal cortex (MPFC, BA8, 9) and decreased fALFF in the left precuneus (PCu, BA7). Furthermore, significantly positive correlation was observed between the z values of the voxels within the bilateral superior MPFC and somatization subscale scores of the Symptom Check List (SCL-90) in patients with SD.
  
  
  CONCLUSIONS
  Our findings indicate that there is a dissociation pattern of the anterior and posterior DMN in first-episode, treatment-naive patients with SD. The results provide new insight for the importance of the DMN in the pathophysiology of SD.
authors.affiliation: Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Qinji
authors.initials: Q
authors.lastname: Su
authors.affiliation: Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Dapeng
authors.initials: D
authors.lastname: Yao
authors.affiliation: Department of Radiology, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Muliang
authors.initials: M
authors.lastname: Jiang
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.affiliation: Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Jiajing
authors.initials: J
authors.lastname: Jiang
authors.affiliation: Mental Health Institute, the 303rd Hospital of Chinese people's Liberation Army, Nanning, Guangxi, China.
authors.forename: Chunxing
authors.initials: C
authors.lastname: Xu
authors.affiliation: Department of Radiology, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Dai
authors.affiliation: Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Miaoyu
authors.initials: M
authors.lastname: Yu
authors.affiliation: Department of Radiology, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Liling
authors.initials: L
authors.lastname: Long
authors.affiliation: Mental Health Institute, the 303rd Hospital of Chinese people's Liberation Army, Nanning, Guangxi, China.
authors.forename: Hongzheng
authors.initials: H
authors.lastname: Li
authors.affiliation: Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Jianrong
authors.initials: J
authors.lastname: Liu
authors.affiliation: Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Zhikun
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Changqing
authors.initials: C
authors.lastname: Xiao
authors.affiliation: Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Guo
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000000981:diagnostic imaging / Q000503:physiopathology; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging / Q000503:physiopathology; D011859:Radiography; D013001:Somatoform Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology