title: An update on the use of melatonin as a stroke therapeutic.
abstract: Delivery of melatonin and targeting melatonin receptors pose as neuroprotective strategies for stroke therapy. The potential of melatonin-based therapeutics for clinical application in stroke patients requires translational research to guide the conduct of clinical trials. We review recent preclinical and clinical data that support the use of melatonin for stroke.
authors.affiliation: Department of Neurosurgery and Brain Repair, Center of Excellence for Aging and Brain Repair, University of South Florida College of Medicine, Tampa, FL, USA - ntajiri@health.edu.
authors.forename: G S
authors.initials: GS
authors.lastname: Gonzales-Portillo
authors.forename: D
authors.initials: D
authors.lastname: Lozano
authors.forename: D
authors.initials: D
authors.lastname: Aguirre
authors.forename: S
authors.initials: S
authors.lastname: Reyes
authors.forename: C V
authors.initials: CV
authors.lastname: Borlongan
authors.forename: N
authors.initials: N
authors.lastname: Tajiri
authors.forename: Y
authors.initials: Y
authors.lastname: Kaneko
mesh_terms: D002986:Clinical Trials as Topic; D006801:Humans; D008550:Melatonin / Q000627:therapeutic use*; D044094:Receptors, Melatonin / Q000187:drug effects; D020521:Stroke / Q000188:drug therapy*
chemical_list: D044094:Receptors, Melatonin; D008550:Melatonin