title: Dry eye in LASIK patients.
abstract: BACKGROUND
  Increasing age is a known risk factor for developing dry eye. The specific aims of the present study were to determine the prevalence of dry eye syndrome (DES) and use of post-operative dry eye medications in a relatively young population presenting for LASIK surgery at an academic ophthalmology clinic.
  
  
  RESULTS
  A retrospective, analysis of 948 de-identified patient charts (median age 39 years, not age stratified) was performed to extract pre-LASIK diagnoses and post-LASIK medication lists. Clinical evaluation for DES and the results of Schirmer's reflex tear flow test were used to assign LASIK patients into Normal, Pre-dry eye (Pre-DES), and Dry Eye Syndrome (DES) groups; which were then compared for use of dry eye medications.Based on pre-operative diagnoses, only 2% (CI: 1.3 - 3.1) of LASIK patients presented with overt DES. Unexpectantly, 25% (CI: 22.2 - 27.6) of LASIK patients labeled Pre-DES were not classified by the clinician as having overt DES, yet they showed poor reflex tear flow rates ≤ 5 mm before surgery, and frequently used post-operative lubricant dry eye medications.
  
  
  CONCLUSIONS
  Although the number of patients with pre-existing eye conditions was unknown, a sizable portion of relatively young LASIK patients displays poor reflex tear flow without overt DES. Such patients could go on to develop more serious consequences of poor tear flow, such as corneal abrasion and erosion. More specific, dry eye medications may be needed for ideal treatment.
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Azuma
authors.forename: Chiho
authors.initials: C
authors.lastname: Yabuta
authors.forename: Frederick W
authors.initials: FW
authors.lastname: Fraunfelder
authors.affiliation: Department of Integrative Biosciences Oregon Health & Science University, Portland, OR 97239, USA. shearert@ohsu.edu.
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Shearer
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D003315:Cornea / Q000187:drug effects / Q000503:physiopathology / Q000601:surgery; D015352:Dry Eye Syndromes / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery; D005260:Female; D006801:Humans; D020731:Keratomileusis, Laser In Situ; D065346:Lubricant Eye Drops / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery; D012307:Risk Factors; D013666:Tears / Q000378:metabolism
chemical_list: D065346:Lubricant Eye Drops