title: MRI-guided laser interstitial thermal therapy in neuro-oncology: a review of its current clinical applications.
abstract: Magnetic resonance imaging-guided laser interstitial thermal therapy (LITT) is a minimally invasive treatment modality with recent increasing use to ablate brain tumors. When originally introduced in the late 1980s, the inability to precisely monitor and control the thermal ablation limited the adoption of LITT in neuro-oncology. Popularized as a means of destroying malignant hepatic and renal metastatic lesions percutaneously, its selective thermal tumor destruction and preservation of adjacent normal tissues have since been optimized for use in neuro-oncology. The progress made in real-time thermal imaging with MRI, laser probe design, and computer algorithms predictive of tissue kill has led to the resurgence of interest in LITT as a means to ablate brain tumors. Current LITT systems offer a surgical option for some inoperable brain tumors. We discuss the origins, principles, current indications, and future directions of MRI-guided LITT in neuro-oncology.
authors.affiliation: The Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Department of Neurological Surgery, Neurological and Taussig Cancer Institutes, Cleveland Clinic, Cleveland, Ohio, USA.
authors.forename: Gazanfar
authors.initials: G
authors.lastname: Rahmathulla
authors.forename: Pablo F
authors.initials: PF
authors.lastname: Recinos
authors.forename: Kambiz
authors.initials: K
authors.lastname: Kamian
authors.forename: Alireza M
authors.initials: AM
authors.lastname: Mohammadi
authors.forename: Manmeet S
authors.initials: MS
authors.lastname: Ahluwalia
authors.forename: Gene H
authors.initials: GH
authors.lastname: Barnett
mesh_terms: D055011:Ablation Techniques / Q000295:instrumentation / Q000379:methods*; D001932:Brain Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000295:instrumentation / Q000379:methods*; D054023:Lasers, Semiconductor; D053783:Magnetic Resonance Imaging, Interventional; D008297:Male; D019635:Neurosurgical Procedures / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D025321:Surgery, Computer-Assisted; D016019:Survival Analysis; D016896:Treatment Outcome