title: [Intra-tumoral hemorrhage of a relapsed CNS diffuse large B-cell lymphoma: a case report].
abstract: We report a case of a relapsed central nervous system(CNS)lymphoma with an intra-tumoral hemorrhage. A 75-year-old man was transferred to our hospital because of sensory aphasia. He was diagnosed with a left temporoparietal brain tumor having intra-tumoral hemorrhage. Emergency resection of the tumor was performed. The pathological diagnosis was diffuse large B-cell lymphoma(DLBCL). Chemotherapy and radiation therapy were performed, and the patient achieved remission. Isolated relapsed CNS DLBCL accompanied by an intra-tumoral hemorrhage has been very rarely reported. Immunohistochemistry findings showed increased expression of vascular endothelial growth factor(VEGF)in the cytoplasm of tumor cells. This may correlate to the intra-tumoral hemorrhage, as indicated by previous reports.
authors.affiliation: Department of Neurosurgery, Osaka Police Hospital.
authors.forename: Tae-Kyun
authors.initials: TK
authors.lastname: Kim
authors.forename: Daisuke
authors.initials: D
authors.lastname: Wajima
authors.forename: Taiji
authors.initials: T
authors.lastname: Yonezawa
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Takamura
authors.forename: Seisuke
authors.initials: S
authors.lastname: Miyamae
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000150:complications / Q000378:metabolism / Q000628:therapy*; D059248:Chemoradiotherapy; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D020300:Intracranial Hemorrhages / Q000209:etiology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000628:therapy*; D016896:Treatment Outcome; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D042461:Vascular Endothelial Growth Factor A