title: Glutathione S-transferase M1 null genotype and hepatocellular carcinoma susceptibility in China and India: evidence from an updated meta-analysis.
abstract: BACKGROUND
  Glutathione S-transferase M1 (GSTM1) have been reported to be associated with hepatocellular carcinoma. However, the effect of the GSTM1 null genotype was divergent in the literature and we therefore performed the present meta-analysis to explore the relationship in detail.
  
  
  METHODS
  Reported studies were searched from 1990 to March 1, 2014 in PubMed and Wanfang Med Online. The total odds oatio (OR) and 95% CI were calculated and analyzed by Review Manager 5.1 and STATE 12.
  
  
  RESULTS
  Total OR was calculated from 26 articles with 3,769 cases and 5,517 controls and the association proved significant (OR [95%CI]=1.50 [1.25, 1.80], P<0.05) in the Chinese population. However, there was no significant association between hepatocellular carcinoma risk among subjects carrying the GSTM1 null genotype (OR [95%CI]=1.20 [0.88-1.64], P=0.24) in subgroups of publication in English and in Indian populations (OR [95%CI]=1.80 [0.80- 4.20], P=0.15).
  
  
  CONCLUSIONS
  The GSTM1 deletion polymorphism might not have a significant effect on the susceptibility of hepatocellular carcinoma overall.
authors.affiliation: Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University Wuhan, China E-mail : zhengfang@whu.edu.cn.
authors.forename: Hong-Zhou
authors.initials: HZ
authors.lastname: Liu
authors.forename: Jie
authors.initials: J
authors.lastname: Peng
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: Peng
authors.forename: Ming
authors.initials: M
authors.lastname: Yan
authors.forename: Fang
authors.initials: F
authors.lastname: Zheng
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007194:India; D008113:Liver Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis
chemical_list: D005982:Glutathione Transferase