title: You're only as old as your arteries: translational strategies for preserving vascular endothelial function with aging.
abstract: Endothelial dysfunction develops with age and increases the risk of age-associated vascular disorders. Nitric oxide insufficiency, oxidative stress, and chronic low-grade inflammation, induced by upregulation of adverse cellular signaling processes and imbalances in stress resistance pathways, mediate endothelial dysfunction with aging. Healthy lifestyle behaviors preserve endothelial function with aging by inhibiting these mechanisms, and novel nutraceutical compounds that favorably modulate these pathways hold promise as a complementary approach for preserving endothelial health.
authors.affiliation: Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado seals@colorado.edu.
authors.forename: Douglas R
authors.initials: DR
authors.lastname: Seals
authors.affiliation: Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado.
authors.forename: Rachelle E
authors.initials: RE
authors.lastname: Kaplon
authors.affiliation: Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado.
authors.forename: Rachel A
authors.initials: RA
authors.lastname: Gioscia-Ryan
authors.affiliation: Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: LaRocca
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001158:Arteries / Q000502:physiology* / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000502:physiology* / Q000503:physiopathology; D006801:Humans; D008019:Life Style; D018384:Oxidative Stress / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D014652:Vascular Diseases / Q000503:physiopathology / Q000517:prevention & control