title: Adenocarcinoma with adenoma in the jejunum suggesting an adenoma-carcinoma sequence in the small bowel: A case report.
abstract: Other than that in the duodenum, adenocarcinoma in the small bowel is rare. The present study describes a case of adenocarcinoma with adenoma in the jejunum. A 70-year-old male was admitted to hospital due to dehydration induced by abdominal discomfort and difficulty with oral intake. Computed tomography revealed a tumor in the upper side of the jejunum, which was subsequently resected. The tumor contained adenocarcinoma and adenoma. The protein expression of p53 and Ki-67 was analyzed in the normal mucosa, adenoma and adenocarcinoma. The number of epithelial cells expressing p53 and Ki-67 was found to increase in the adenoma tissue compared with that in the normal mucosa. In the adenocarcinoma tissue, the number of cells expressing p53 and Ki-67 further increased, suggesting that an adenoma-adenocarcinoma sequence may occur in the small bowel, similar to that observed in the large bowel.
authors.affiliation: Department of Surgical Pathology, Kansai Medical University-Hirakata Hospital, Osaka 573-1191, Japan ; Division of Surgical Pathology, Toyooka Hospital, Hyogo 668-8501, Japan.
authors.forename: Yorika
authors.initials: Y
authors.lastname: Nakano
authors.affiliation: Division of Surgical Pathology, Toyooka Hospital, Hyogo 668-8501, Japan ; Department of Stem Cell Disorders, Kansai Medical University, Osaka 573-1010, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Adachi
authors.affiliation: Department of Surgery, Asago-Yanase Medical Center, Hyogo 669-5103, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Okamoto
authors.affiliation: Department of Surgery, Asago-Yanase Medical Center, Hyogo 669-5103, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kiyama
authors.affiliation: Department of Radiology, Toyooka Hospital, Hyogo 668-8501, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Koyama
authors.affiliation: LSI Medience Corporation, Tokyo 174-0051, Japan.
authors.forename: Shin-Ichi
authors.initials: SI
authors.lastname: Nakamura
authors.affiliation: Department of Stem Cell Disorders, Kansai Medical University, Osaka 573-1010, Japan.
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Surgical Pathology, Kansai Medical University-Hirakata Hospital, Osaka 573-1191, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Sakaida
authors.affiliation: Department of Surgical Pathology, Kansai Medical University-Hirakata Hospital, Osaka 573-1191, Japan.
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Uemura
authors.affiliation: Department of Stem Cell Disorders, Kansai Medical University, Osaka 573-1010, Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Ikehara
keywords: Ki-67; adenocarcinoma; adenoma; jejunum; p53; small bowel