title: Effects of several acetylated chitooligosaccharides on antioxidation, antiglycation and NO generation in erythrocyte.
abstract: Three kinds of chitooligosaccharides (COS) with different degrees of deacetylation were prepared and named MD90, MD70 and MD50, respectively. Antioxidation, antiglycation and nitric oxide (NO) promotion in erythrocyte of these samples were investigated. The results showed that COS, especially MD90 had obviously inhibitory effects on oxidation and glycation. In addition, MD90 displayed stronger effect on increasing endogenous NO content than both MD70 and MD50, whose degrees of deacetylation were lower. The results indicated that amino group in COS has a certain effect on the activities of COS. As COS have a conformed activity to treat diabetes, the results of this study may be meaningful for further understanding the mechanism of the action.
authors.affiliation: Pharmacy College of Harbin Medical University, Xuefu Street 194, Nangang District, Harbin 150081, PR China.
authors.forename: Chang-Mei
authors.initials: CM
authors.lastname: Zhang
authors.affiliation: Pharmacy College of Harbin Medical University, Xuefu Street 194, Nangang District, Harbin 150081, PR China.
authors.forename: Shu-Han
authors.initials: SH
authors.lastname: Yu
authors.affiliation: Pharmacy College of Harbin Medical University, Xuefu Street 194, Nangang District, Harbin 150081, PR China.
authors.forename: Liang-Shuan
authors.initials: LS
authors.lastname: Zhang
authors.affiliation: Pharmacy College of Harbin Medical University, Xuefu Street 194, Nangang District, Harbin 150081, PR China.
authors.forename: Zhan-Yi
authors.initials: ZY
authors.lastname: Zhao
authors.affiliation: Pharmacy College of Harbin Medical University, Xuefu Street 194, Nangang District, Harbin 150081, PR China. Electronic address: 710752984@qq.com.
authors.forename: Lu-Lu
authors.initials: LL
authors.lastname: Dong
mesh_terms: D000107:Acetylation; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D048271:Chitosan / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism*; D006031:Glycosylation / Q000187:drug effects; D006801:Humans; D009569:Nitric Oxide / Q000096:biosynthesis*; D009844:Oligosaccharides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010084:Oxidation-Reduction / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000975:Antioxidants; D009844:Oligosaccharides; D009569:Nitric Oxide; D048271:Chitosan
keywords: Antiglycation; Antioxidation; Chitooligosaccharides; Degree of deacetylation; Nitric oxide