title: BCL11Agene DNA methylation contributes to the risk of type 2 diabetes in males.
abstract: BCL11Ais a critical modulator involved in hemoglobin switching. Recent studies have established an association betweenBCL11Agene polymorphisms and a risk of type 2 diabetes (T2D). The aim of the present study was to assess the correlation betweenBCL11ADNA methylation and T2D. A total of 48 T2D cases and 48 age- and gender-matched controls were recruited to evaluateBCL11Amethylation using bisulfite pyrosequencing technology. Although no significant association was observed inBCL11Amethylation between T2D patients and healthy controls (P=0.322), breakdown analysis by gender identified a significant association betweenBCL11Amethylation and T2D in males (P=0.018). Notably, there was also a significant female-specific association between the meanBCL11ADNA methylation and triglyceride (TG) concentration (r=-0.34; P=0.019). The results indicated thatBCL11Amethylation contributed to the risk of T2D in males. In addition,BCL11Amethylation may have an effect on the development of T2D by influencing TG metabolism. Thus, gender difference may provide new information to aid the understanding of T2D pathogenesis.
authors.affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University, Ningbo, Zhejiang 315211, P.R. China ; The Affiliated Hospital, School of Medicine, Ningbo University, Ningbo, Zhejiang 315000, P.R. China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Tang
authors.affiliation: Bank of Blood Products, Ningbo No. 2 Hospital, Ningbo, Zhejiang 315010, P.R. China.
authors.forename: Lingyan
authors.initials: L
authors.lastname: Wang
authors.affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors.forename: Huadan
authors.initials: H
authors.lastname: Ye
authors.affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors.forename: Xuting
authors.initials: X
authors.lastname: Xu
authors.affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors.forename: Qingxiao
authors.initials: Q
authors.lastname: Hong
authors.affiliation: Section of Endocrinology, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Wang
authors.affiliation: The Affiliated Hospital, School of Medicine, Ningbo University, Ningbo, Zhejiang 315000, P.R. China ; Bank of Blood Products, Ningbo No. 2 Hospital, Ningbo, Zhejiang 315010, P.R. China.
authors.forename: Leiting
authors.initials: L
authors.lastname: Xu
authors.affiliation: Bank of Blood Products, Ningbo No. 2 Hospital, Ningbo, Zhejiang 315010, P.R. China.
authors.forename: Shizhong
authors.initials: S
authors.lastname: Bu
authors.affiliation: The Affiliated Hospital, School of Medicine, Ningbo University, Ningbo, Zhejiang 315000, P.R. China ; Bank of Blood Products, Ningbo No. 2 Hospital, Ningbo, Zhejiang 315010, P.R. China.
authors.forename: Lina
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University, Ningbo, Zhejiang 315211, P.R. China ; The Affiliated Hospital, School of Medicine, Ningbo University, Ningbo, Zhejiang 315000, P.R. China.
authors.forename: Jia
authors.initials: J
authors.lastname: Cheng
authors.affiliation: The Affiliated Hospital, School of Medicine, Ningbo University, Ningbo, Zhejiang 315000, P.R. China.
authors.forename: Panpan
authors.initials: P
authors.lastname: Liu
authors.affiliation: The Affiliated Hospital, School of Medicine, Ningbo University, Ningbo, Zhejiang 315000, P.R. China.
authors.forename: Meng
authors.initials: M
authors.lastname: Ye
authors.affiliation: The Affiliated Hospital, School of Medicine, Ningbo University, Ningbo, Zhejiang 315000, P.R. China.
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Mai
authors.affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University, Ningbo, Zhejiang 315211, P.R. China ; The Affiliated Hospital, School of Medicine, Ningbo University, Ningbo, Zhejiang 315000, P.R. China.
authors.forename: Shiwei
authors.initials: S
authors.lastname: Duan
keywords: BCL11A; CpG island; DNA methylation; gender; type 2 diabetes