title: SnapShot: sirtuins, NAD, and aging.
abstract: Sirtuins are highly conserved nicotinamide adenine dinucleotide (NAD)-dependent enzymes that regulate a wide range of biological processes, including aging, in several species. This SnapShot provides a comprehensive overview of the targets, enzymatic activities, and physiological functions of the seven mammalian sirtuins, as well as the regulation of the biosynthetic pathways regulating NAD availability.
authors.affiliation: Frontier Research Core for Life Sciences, University of Toyama, Toyama 930-0194, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakagawa
authors.affiliation: Paul F. Glenn Laboratory for the Science of Aging and Department of Biology, and The Koch Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
authors.forename: Leonard
authors.initials: L
authors.lastname: Guarente
mesh_terms: D000375:Aging; D031204:Caloric Restriction; D006657:Histones / Q000378:metabolism; D006801:Humans; D009243:NAD / Q000378:metabolism*; D037761:Sirtuins / Q000378:metabolism*
chemical_list: D006657:Histones; D009243:NAD; D037761:Sirtuins