title: The molecular basis of IL-10 function: from receptor structure to the onset of signaling.
abstract: Assembly of the cell surface IL-10 receptor complex is the first step in initiating IL-10 signaling pathways that regulate intestinal inflammation, viral persistence and even tumor surveillance. The discovery of IL-10 homologs in the genomes of herpes viruses suggests IL-10 signaling pathways can be manipulated at the level of the receptor complex. This chapter will describe our current molecular understanding of IL-10 receptor assembly based on crystal structures and biochemical analyses of cellular and viral IL-10 receptor complexes.
authors.affiliation: Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA, walter@uab.edu.
authors.forename: Mark R
authors.initials: MR
authors.lastname: Walter
mesh_terms: D000818:Animals; D006801:Humans; D016753:Interleukin-10 / Q000737:chemistry / Q000502:physiology*; D008958:Models, Molecular; D011487:Protein Conformation; D053701:Receptors, Interleukin-10 / Q000737:chemistry*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D053701:Receptors, Interleukin-10; D016753:Interleukin-10