title: Ugi 4-CR Synthesis of γ- and δ-Lactams providing new access to diverse enzyme interactions, a PDB analysis.
abstract: A three step synthesis ofN-unsubstituted tetrazolo γ- and δ-lactams involving a key Ugi-4CR is presented. The compounds, otherwise difficult to access, are conveniently synthesized in overall good yields by our route. PDB analysis of theN-unsubstituted γ- and δ-lactam fragment reveals a strongly tri-directional hydrogen bond donor acceptor interaction with the amino acids of the binding sites.
authors.affiliation: Department of Pharmacy University of Groningen A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
authors.forename: André
authors.initials: A
authors.lastname: Boltjes
authors.affiliation: Department of Pharmacy University of Groningen A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
authors.forename: George P
authors.initials: GP
authors.lastname: Liao
authors.affiliation: Department of Pharmacy University of Groningen A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
authors.forename: Ting
authors.initials: T
authors.lastname: Zhao
authors.affiliation: Department Chemie Technische Universität München Lichtenbergstrasse 4, D-85747 Garching bei München, Germany.
authors.forename: Eberhardt
authors.initials: E
authors.lastname: Herdtweck
authors.affiliation: Department of Pharmacy University of Groningen A. Deusinglaan 1, 9713 AV Groningen, The Netherlands ; Department of Chemistry University of Pittsburgh 3501 Fifth Avenue, Pittsburgh, PA 15261, USA.
authors.forename: Alexander
authors.initials: A
authors.lastname: Dömling