title: Management of Liver Cancer Argon-helium Knife Therapy with Functional Computer Tomography Perfusion Imaging.
abstract: The objective of this study was to observe the change in blood perfusion of liver cancer following argon-helium knife treatment with functional computer tomography perfusion imaging. Twenty-seven patients with primary liver cancer treated with argon-helium knife and were included in this study. Plain computer tomography (CT) and computer tomography perfusion (CTP) imaging were conducted in all patients before and after treatment. Perfusion parameters including blood flows, blood volume, hepatic artery perfusion fraction, hepatic artery perfusion, and hepatic portal venous perfusion were used for evaluating therapeutic effect. All parameters in liver cancer were significantly decreased after argon-helium knife treatment (p < 0.05 to all). Significant decrease in hepatic artery perfusion was also observed in pericancerous liver tissue, but other parameters kept constant. CT perfusion imaging is able to detect decrease in blood perfusion of liver cancer post-argon-helium knife therapy. Therefore, CTP imaging would play an important role for liver cancer management followed argon-helium knife therapy.
authors.affiliation: Department of Ultrasonography, The Second Hospital of Harbin Medical University, Nangang District, Harbin 150086, China.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Radiology, The Second Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin 150086, China.
authors.forename: Shengjie
authors.initials: S
authors.lastname: Shu
authors.affiliation: Department of Radiology, The Second Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin 150086, China.
authors.forename: Jinping
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Radiology, The Second Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin 150086, China jhjemail@163.com.
authors.forename: Huijie
authors.initials: H
authors.lastname: Jiang
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003452:Cryosurgery; D005260:Female; D006801:Humans; D008099:Liver / Q000098:blood supply / Q000000981:diagnostic imaging / Q000601:surgery; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D055420:Perfusion Imaging; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
keywords: Argon-helium knife; Computer tomography perfusion; Liver cancer