title: Intravenous thrombolysis for acute ischaemic stroke in the setting of rivaroxaban use.
abstract: The risk of thrombolysis in patients taking novel anticoagulants remains unclear. We describe a patient with a large acute ischaemic stroke, who had a low calibrated anti-factor Xa level, who safely received thrombolysis 15-17 hours after standard dose rivaroxaban without subsequent intracerebral haemorrhage.
authors.affiliation: Department of Medicine and Neurology, Royal Melbourne Hospital, University of Melbourne, Grattan Street, Parkville, VIC 3052, Australia. Electronic address: andrew.neal@mh.org.au.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Neal
authors.affiliation: Department of Medicine and Neurology, Royal Melbourne Hospital, University of Melbourne, Grattan Street, Parkville, VIC 3052, Australia.
authors.forename: Bruce C V
authors.initials: BC
authors.lastname: Campbell
authors.affiliation: Department of Medicine and Neurology, Royal Melbourne Hospital, University of Melbourne, Grattan Street, Parkville, VIC 3052, Australia.
authors.forename: Arvind
authors.initials: A
authors.lastname: Chandratheva
authors.affiliation: Department of Medicine and Neurology, Royal Melbourne Hospital, University of Melbourne, Grattan Street, Parkville, VIC 3052, Australia.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Hand
authors.affiliation: Department of Medicine and Neurology, Royal Melbourne Hospital, University of Melbourne, Grattan Street, Parkville, VIC 3052, Australia.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Davis
mesh_terms: D061605:Administration, Intravenous; D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage*; D002545:Brain Ischemia / Q000150:complications*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D000069552:Rivaroxaban / Q000008:administration & dosage*; D020521:Stroke / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D015912:Thrombolytic Therapy / Q000009:adverse effects / Q000379:methods; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D000925:Anticoagulants; D005343:Fibrinolytic Agents; D000069552:Rivaroxaban
keywords: Rivaroxaban; Stroke; Thrombolysis; Thrombolytic therapy