title: In vitro and in vivo CT imaging using bismuth sulfide modified with a highly biocompatible Pluronic F127.
abstract: Probe bismuth sulfide modified with Pluronic F127 (Bi2S3-PF127), which has high biocompatibility and dispersibility, is synthesized using triblock copolymer Pluronic F127 to modify hydrophobic Bi2S3 nanoparticles that are prepared by a hot injection method. TEM results show that most of the probe has a length of about 14.85 ± 1.70 nm and a breadth of about 4.79 ± 0.63 nm. After injected into the tail vein of a mouse, the probe has obvious CT contrast enhancement capability from x-ray CT imaging results. Meanwhile, the probe's in vivo toxicity is also studied. It is found that hematoxylin and eosin stains of major organs have no change. A biochemical analysis (alanine aminotransferase and aspartate aminotransferase) prove the probe has no adverse effects. The results of a blood analysis (white blood cell count, red blood cell count, hemoglobin, and platelet count) are also normal. The biological distribution of Bi by ICP-AES shows that most of nanoparticles are cleaned out after injection 48 h, and the circulation half-life of the probe is 5.0 h, suggesting that Bi2S3-PF127 has a long circulation and indicating that the Bi2S3-PF127 probe has good biocompatibility and safety.
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.forename: Xiao-Quan
authors.initials: XQ
authors.lastname: Yang
authors.forename: Yuan-Zheng
authors.initials: YZ
authors.lastname: Meng
authors.forename: Huan-Huan
authors.initials: HH
authors.lastname: Huang
authors.forename: Meng-Yao
authors.initials: MY
authors.lastname: Qin
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Yan
authors.forename: Yuan-Di
authors.initials: YD
authors.lastname: Zhao
authors.forename: Zhi-Ya
authors.initials: ZY
authors.lastname: Ma
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects / Q000138:chemical synthesis*; D001729:Bismuth / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects; D003287:Contrast Media / Q000009:adverse effects / Q000138:chemical synthesis*; D051379:Mice; D008807:Mice, Inbred BALB C; D053758:Nanoparticles / Q000009:adverse effects / Q000737:chemistry*; D020442:Poloxamer / Q000737:chemistry; D013440:Sulfides / Q000737:chemistry; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D001672:Biocompatible Materials; D003287:Contrast Media; D013440:Sulfides; D020442:Poloxamer; D001729:Bismuth; C049897:bismuth sulfide