title: Characterization of a brain permeant fluorescent molecule and visualization of Aβ parenchymal plaques, using real-time multiphoton imaging in transgenic mice.
abstract: Emerging paradigms mandate discovery of imaging agents for diagnosing Alzheimer's disease (AD) prior to appearance of clinical symptoms. To accomplish this objective, a novel heterocyclic molecule (4) was synthesized and validated as Aβ targeted probe. The agent shows labeling of numerous diffuse Aβ plaques in confirmed AD human brain tissues and traverses the blood-brain barrier to enable labeling of parenchymal Aβ plaques in live mice (APP(±)/PS1(±)) brains.
authors.affiliation: BRIGHT Institute, Molecular Imaging Center, ‡Mallinckrodt Institute of Radiology, §Department of Biomedical Engineering, ∥Departments of Neurology and ⊥Pathology & Immunology, #Knight Alzheimer's Disease Research Center, and ∇Hope Center for Neurological Disorders, Washington University School of Medicine , St. Louis, Missouri 63110, United States.
authors.forename: G S M
authors.initials: GS
authors.lastname: Sundaram
authors.forename: Kanchan
authors.initials: K
authors.lastname: Garai
authors.forename: Nigam P
authors.initials: NP
authors.lastname: Rath
authors.forename: Ping
authors.initials: P
authors.lastname: Yan
authors.forename: John R
authors.initials: JR
authors.lastname: Cirrito
authors.forename: Nigel J
authors.initials: NJ
authors.lastname: Cairns
authors.forename: Jin-Moo
authors.initials: JM
authors.lastname: Lee
authors.forename: Vijay
authors.initials: V
authors.lastname: Sharma
mesh_terms: D000544:Alzheimer Disease / Q000473:pathology*; D000818:Animals; D052160:Benzothiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D001921:Brain / Q000473:pathology*; D004396:Coloring Agents; D003952:Diagnostic Imaging; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D015394:Molecular Structure; D058225:Plaque, Amyloid / Q000473:pathology*; D049268:Positron-Emission Tomography; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: C000596681:(E)-5-(2-(6-(2-fluoroethoxy)benzo(d)thiazol-2-yl)vinyl)-N,N-dimethylpyridin-2-amine; D052160:Benzothiazoles; D004396:Coloring Agents; D005456:Fluorescent Dyes; D011725:Pyridines