title: An unexpected copper(II)-catalyzed three-component reaction of quinazoline 3-oxide, alkylidenecyclopropane, and water.
abstract: An unexpected copper(II)-catalyzed three-component reaction of quinazoline-3-oxide, alkylidenecyclopropane and water under mild conditions is reported. This transformation including [3+2] cycloaddition and intramolecular rearrangement leads to N-(2-(5-oxa-6-azaspiro[2.4]hept-6-en-7-yl)phenyl)formamides in good yields.
authors.affiliation: Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China. jie_wu@fudan.edu.cn.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: An
authors.forename: Danqing
authors.initials: D
authors.lastname: Zheng
authors.forename: Jie
authors.initials: J
authors.lastname: Wu
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D061565:Cycloaddition Reaction; D003521:Cyclopropanes / Q000737:chemistry*; D005559:Formamides / Q000138:chemical synthesis*; D010087:Oxides / Q000737:chemistry*; D011799:Quinazolines / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D003521:Cyclopropanes; D005559:Formamides; D010087:Oxides; D011799:Quinazolines; D014867:Water; D003300:Copper