title: Prevalence of autoantibodies in type 1 diabetes patients and its association with the clinical presentation - UAE Eastern Region experience.
abstract: BACKGROUND
  Positive autoantibodies and its association with the clinical course of type 1 diabetes mellitus (T1DM) have been reported worldwide, however, no such data have been reported in United Arab Emirates population.
  
  
  OBJECTIVE
  To study the prevalence of positive autoantibodies in T1DM pediatric patients and its association with the clinical presentation.
  
  
  METHODS
  Descriptive retrospective chart review of all new cases of pediatric T1DM at Tawam Hospital. Electronic patient records accessed to obtain data.
  
  
  RESULTS
  61 patients were identified. 88%±8.1 had at least 1 positive antibody and 82% of all patients were positive for anti-glutamic acid decarboxylase (GAD). While comparing the group of any positive antibody (n=54) with the group of all negative antibodies (n=7), a significant difference was found in the mean HbA1C (p=0.02) and nationality (p=0.03).
  
  
  CONCLUSIONS
  The vast majority of our T1DM pediatric patients are autoantibody positive, and anti-GAD antibodies were the most commonly detected antibodies.
authors.forename: Noura
authors.initials: N
authors.lastname: Al-Hassani
authors.forename: Fares
authors.initials: F
authors.lastname: Chedid
authors.forename: Suha
authors.initials: S
authors.lastname: Hadi
authors.forename: Walid
authors.initials: W
authors.lastname: Kaplan
mesh_terms: D000293:Adolescent; D001323:Autoantibodies / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000453:epidemiology* / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D005968:Glutamate Decarboxylase / Q000276:immunology*; D006801:Humans; D007223:Infant; D008297:Male; D015995:Prevalence; D011379:Prognosis; D012189:Retrospective Studies; D014479:United Arab Emirates / Q000453:epidemiology
chemical_list: D001323:Autoantibodies; D005968:Glutamate Decarboxylase