title: [Dosimetric comparison of external partial breast irradiation with whole breast irradiation and partial breast brachytherapy].
abstract: Different techniques exist for the delivery of radiotherapy after breast conserving surgery. The conventional method is whole breast irradiation. However, in selected patients partial breast irradiation can be performed, either with external beams or brachytherapy. In the current study three irradiation techniques are compared regarding dosimetric aspects. Treatment plans of thirty women treated with external beam conformal partial breast irradiation (CONF) were evaluated using dose-volume histograms. For the same patients whole breast irradiation plans (WBI) were made and compared with the CONF ones. Breast and lung of both sides, and heart at left sided lesions were contoured as organs at risk. After this, dose plans of another thirty patients treated with interstitial brachytherapy (IBT) were analyzed and compared with the CONF plans. According to our results the 90% isodose curve covered at least 97% of the target volume at all three techniques, and this value was 100% for CONF. The maximal dose within target volume was 106% in CONF and 115% in WBI plans. Volume of ipsilateral breast receiving the prescribed dose was 66%, 15% and 13% in the WBI, CONF and IBT plans, respectively. The dose to the contralateral breast was less for CONF compared to WBI. Volume of the ipsilateral lung receiving 30% of the prescribed dose was 15%, 8% and 1%, the maximal dose was 105%, 94% and 47% in the WBI, CONF and IBT plans, respectively. In the same order the maximal dose to the heart was 82%, 49% and 25%, while the dose irradiated to 5% of the heart volume was 27%, 19% and 14% at left sided lesions. Regarding target coverage, the conformal technique was the best, and the dose was more homogeneous than at WBI. With respect to dose to organs at risk the partial breast irradiation techniques were much more favorable than WBI, and the lowest doses occurred in the IBT treatment plans.
authors.affiliation: Sugárterápiás Központ, Országos Onkológiai Intézet, Budapest, Hungary. major@oncol.hu.
authors.forename: István
authors.initials: I
authors.lastname: Bodács
authors.affiliation: Sugárterápiás Központ, Országos Onkológiai Intézet, Budapest, Hungary. major@oncol.hu.
authors.forename: Csaba
authors.initials: C
authors.lastname: Polgár
authors.affiliation: Sugárterápiás Központ, Országos Onkológiai Intézet, Budapest, Hungary. major@oncol.hu.
authors.forename: Tibor
authors.initials: T
authors.lastname: Major
mesh_terms: D001918:Brachytherapy; D001943:Breast Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D005260:Female; D006321:Heart / Q000528:radiation effects; D006801:Humans; D008168:Lung / Q000528:radiation effects; D015412:Mastectomy, Segmental; D009367:Neoplasm Staging; D011874:Radiometry; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D020266:Radiotherapy, Conformal; D016896:Treatment Outcome