title: 68Ga DOTANOC PET/CT aiding in the diagnosis of von Hippel-Lindau syndrome by detecting cerebellar hemangioblastoma and adrenal pheochromocytoma.
abstract: A 35-year-old man with clinical suspicion of adrenal pheochromocytoma was evaluated using Ga DOTANOC PET/CT. PET/CT demonstrated Ga DOTANOC-avid right adrenal mass and cerebellar lesion, raising the suspicion of adrenal pheochromocytoma with cerebellar hemangioblastoma suggesting von Hippel-Lindau (VHL) syndrome. Cerebellar lesion on further evaluation with MRI was suggestive of cerebellar hemangioblastoma. Surgical resection of the adrenal mass revealed pheochromocytoma, and genetic analysis revealed mutation involving the chromosome 3p, confirming the diagnosis of VHL syndrome. Ga DOTANOC PET/CT in our patient helped in the diagnosis of VHL syndrome and changed the disease management.
authors.affiliation: From the Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Anirban
authors.initials: A
authors.lastname: Mukherjee
authors.forename: Sellam
authors.initials: S
authors.lastname: Karunanithi
authors.forename: Chandrasekhar
authors.initials: C
authors.lastname: Bal
authors.forename: Rakesh
authors.initials: R
authors.lastname: Kumar
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000000981:diagnostic imaging*; D000328:Adult; D002528:Cerebellar Neoplasms / Q000000981:diagnostic imaging*; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics; D018325:Hemangioblastoma / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D064847:Multimodal Imaging; D009154:Mutation; D009942:Organometallic Compounds; D010673:Pheochromocytoma / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed; D006623:von Hippel-Lindau Disease / Q000000981:diagnostic imaging* / Q000235:genetics
chemical_list: C504894:68Ga-DOTANOC; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals