title: Pyramidal sensor platform with reversible chiroptical signals for DNA detection.
abstract: A heterogeneous chiral sensor for DNA detection is demonstrated by post-assembly system reconfiguration for two types of NPs pyramids. In the presence of target DNA, two types of NPs pyramids undergo dynamic reconfiguration or dissociation process which functions as an off-on or on-off switch towards CD signals changes. Under optimized conditions, the detection limit of this approach can reach to 3.4 aM with no involvement of amplification process.
authors.affiliation: State Key Lab of Food Science & Technology, School of Food Science & Technology, Jiangnan University, Wuxi, 214122, China.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Yan
authors.forename: Liguang
authors.initials: L
authors.lastname: Xu
authors.forename: Wei
authors.initials: W
authors.lastname: Ma
authors.forename: Liqiang
authors.initials: L
authors.lastname: Liu
authors.forename: Libing
authors.initials: L
authors.lastname: Wang
authors.forename: Hua
authors.initials: H
authors.lastname: Kuang
authors.forename: Chuanlai
authors.initials: C
authors.lastname: Xu
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D004277:DNA, Single-Stranded / Q000032:analysis*; D006046:Gold / Q000737:chemistry*; D057230:Limit of Detection; D053768:Metal Nanoparticles / Q000737:chemistry*; D009904:Optical Rotation; D010316:Particle Size; D058105:Polymerization; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation; D013237:Stereoisomerism
chemical_list: D004277:DNA, Single-Stranded; D006046:Gold
keywords: chirality geometry; nanoparticles; reconfiguration