title: Alpha 1-adrenoceptor blocker may improve not only voiding but also storage lower urinary tract symptoms caused by (125) I brachytherapy for prostate cancer.
abstract: Purpose. To assess changes in lower urinary tract symptoms (LUTS) within 1 year after brachytherapy in patients receiving alpha 1-adrenoceptor antagonists. Methods. We retrospectively evaluated 116 patients who underwent (125)I prostate brachytherapy in our institute. Seventy-one patients were treated with a combination of external beam radiation therapy and brachytherapy. Alpha 1-adrenoceptor antagonists were prescribed to all patients after brachytherapy. International Prostate Symptom Score (IPSS) forms and postvoid residual urine volume were recorded at all follow-up visits. Results. Forty-nine patients were given tamsulosin hydrochloride, 32 were given silodosin hydrochloride, and 35 were given naftopidil for up to 6 months after seed implantation. Patients given tamsulosin or naftopidil tended to show a higher peak IPSS and slower recovery to baseline values than those given silodosin. The patients given naftopidil showed an insufficient recovery in storage symptoms in naftopidil group in comparison with tamsulosin group at 3 months and with silodosin group at 6 and 9 months. Conclusions. In the management of LUT after brachytherapy, silodosin may provide a more favorable improvement. Silodosin and tamsulosin may have an advantage in improving not only voiding but also storage lower urinary tract symptoms after brachytherapy.
authors.affiliation: Department of Urology, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Fukui 910-1193, Japan.
authors.forename: Nobuyuki
authors.identifier: 0000-0001-9349-8909
authors.initials: N
authors.lastname: Oyama
authors.affiliation: Department of Urology, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Fukui 910-1193, Japan.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Aoki
authors.affiliation: Department of Urology, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Fukui 910-1193, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Ito
authors.affiliation: Department of Urology, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Fukui 910-1193, Japan.
authors.forename: Yoshiji
authors.initials: Y
authors.lastname: Miwa
authors.affiliation: Department of Urology, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Fukui 910-1193, Japan.
authors.forename: Hironobu
authors.initials: H
authors.lastname: Akino
authors.affiliation: Department of Radiology, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan.
authors.forename: Yoshitaka
authors.identifier: 0000-0003-3569-6717
authors.initials: Y
authors.lastname: Sato
authors.affiliation: Department of Radiology, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Shioura
authors.affiliation: Department of Radiology, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan.
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Kimura
authors.affiliation: Department of Urology, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Fukui 910-1193, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Yokoyama