title: Presynaptic mechanisms of neuronal plasticity and their role in epilepsy.
abstract: Synaptic communication requires constant adjustments of pre- and postsynaptic efficacies. In addition to synaptic long term plasticity, the presynaptic machinery underlies homeostatic regulations which prevent out of range transmitter release. In this minireview we will discuss the relevance of selected presynaptic mechanisms to epilepsy including voltage- and ligand-gated ion channels as well as cannabinoid and adenosine receptor signaling.
authors.forename: Jochen C
authors.initials: JC
authors.lastname: Meier
authors.affiliation: RNA Editing and Hyperexcitability Disorders, Max Delbrück Centre for Molecular Medicine, Neurosciences Berlin, Germany.
authors.forename: Jochen
authors.initials: J
authors.lastname: Meier
authors.affiliation: RNA Editing and Hyperexcitability Disorders, Max Delbrück Centre for Molecular Medicine, Neurosciences Berlin, Germany.
authors.forename: Marcus
authors.initials: M
authors.lastname: Semtner
authors.affiliation: RNA Editing and Hyperexcitability Disorders, Max Delbrück Centre for Molecular Medicine, Neurosciences Berlin, Germany.
authors.forename: Aline
authors.initials: A
authors.lastname: Winkelmann
authors.affiliation: Oscar Langendorff Institute of Physiology, University of Rostock Rostock, Germany.
authors.forename: Jakob
authors.initials: J
authors.lastname: Wolfart
keywords: RNA editing; axon; epilepsy; glycine receptor; hippocampus; homeostatic regulation; neuropsychiatric disorders; potassium channels