title: Herbal medicines for the treatment of nonalcoholic steatohepatitis: current scenario and future prospects.
abstract: Nonalcoholic steatohepatitis (NASH) is a multifactorial disease and has close correlations with other metabolic disorders. This makes its treatment difficult using a single pharmacological drug. Use of plant extract/decoction or polyherbal formulation to treat various liver diseases is very well mentioned in various traditional systems of medicine (Ayurveda, Japanese or traditional Chinese Medicine, and Kampo medicine). Medicinal herbs are known for their multifaceted implications and thus can form an effective treatment schedule against NASH. Till date, several plant extracts, polyherbal formulations, and phytochemicals have been evaluated for their possible therapeutic potential in preventing onset and progression of NASH in experimental models, but clinical studies using the same are sparse. Herbal extracts with antioxidants, antidiabetic, and antihyperlipidemic properties have been shown to ameliorate symptoms of NASH. This review article is a meticulous compilation of our current knowledge on the role of natural products in alleviating NASH and possible lacunae in research that needs to be addressed.
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Medicine, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA.
authors.forename: Ravirajsinh
authors.identifier: 0000-0002-1712-454X
authors.initials: R
authors.lastname: Jadeja
authors.affiliation: Division of Phytotherapeutics and Metabolic Endocrinology, Department of Zoology, Faculty of Science, The M. S. University of Baroda, Vadodara, Gujarat 390002, India.
authors.forename: Ranjitsinh V
authors.initials: RV
authors.lastname: Devkar
authors.affiliation: School of Science and Health, University of Western Sydney, Sydney, NSW 2751, Australia ; NICM, Centre for Complementary Medicine Research, University of Western Sydney, Sydney, NSW 2751, Australia.
authors.forename: Srinivas
authors.identifier: 0000-0002-4735-2789
authors.initials: S
authors.lastname: Nammi