title: [Diabetic cardiomyopathy in medical examination patients with impaired glucose tolerance and Type 2 diabetes].
abstract: OBJECTIVE
  To investigate the change of diabetic cardiomyopathy in patients with impaired glucose tolerance (IGT) and Type 2 diabetes (T2DM) and its influencing factors.
  
  
  METHODS
  Patients with IGT and T2DM were divided into an IGT group (n=314), a T2DM group (n=368) and an NC group (400 normal subjects). The left ventricular ejection fractions (LVEF) and the interventricular septal depth (IVSd) were measured by Doppler echocardiography. The general information and blood biochemistry were also collected during the corresponding time period.
  
  
  RESULTS
  Compared with the NC group, waist circumference (WC), bodymass index (BMI), premature family history of cardiovascular disease, the serum levels of fasting plasma glucose (FPG), HbA1c, TC, TG, hyperlipidemia, BUN and Cr significantly increased (P<0.01) in the IGT and T2DM groups. Compared with the NC group and the IGT group, the LVEF significantly decreased (P<0.01) and the IVSd significantly increased (P<0.01) in the T2DM group. The LVEF and IVSd did not have obvious difference between the NC group and the IGT group. Pearson correlation analysis showed a negative correlation between LVEF and HbA1c, TC and duration of disease (P<0.01); but a positive correlation between IVSd and WC, BMI, HbA1c and duration of disease, and a negative correlation between IVSd and HDL (P<0.05). In the multiple linear stepwise regression, HbA1c and duration of disease showed a significant association with both LVEF and IVSd (P<0.05).
  
  
  CONCLUSIONS
  T2DM has a close association with cardiomyopathy. HbA1c and duration of disease are the independent predictors for LVEF and IVSd.
authors.affiliation: Health Management Center, Third Xiangya Hospital, Central South University, Changsha 410013,China.
authors.forename: Yaqin
authors.initials: Y
authors.lastname: Wang
authors.forename: Pingting
authors.initials: P
authors.lastname: Yang
authors.forename: Xia
authors.initials: X
authors.lastname: Cao
authors.forename: Meilin
authors.initials: M
authors.lastname: Liu
authors.forename: Zhiheng
authors.initials: Z
authors.lastname: Chen
mesh_terms: D001786:Blood Glucose; D015992:Body Mass Index; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D058065:Diabetic Cardiomyopathies / Q000503:physiopathology*; D015150:Echocardiography, Doppler; D018149:Glucose Intolerance; D006442:Glycated Hemoglobin; D006801:Humans; D016277:Ventricular Function, Left; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human