title: Acceleration of tissue plasminogen activator-mediated thrombolysis by magnetically powered nanomotors.
abstract: Dose control and effectiveness promotion of tissue plasminogen activator (t-PA) for thrombolysis are vitally important to alleviate serious side effects such as hemorrhage in stroke treatments. In order to increase the effectiveness and reduce the risk of stroke treatment, we use rotating magnetic nanomotors to enhance the mass transport of t-PA molecules at the blood clot interface for local ischemic stroke therapy. The in vitro experiments demonstrate that, when combined with magnetically activated nanomotors, the thrombolysis speed of low-concentration t-PA (50 μg mL(-1)) can be enhanced up to 2-fold, to the maximum lysis speed at high t-PA concentration. Based on the convection enhanced transport theory due to rotating magnetic nanomotors, a theoretical model is proposed and predicts the experimental results reasonably well. The validity and efficiency of this enhanced treatment has been demonstrated in a rat embolic model.
authors.affiliation: College of Engineering and ‡Department of Physics and Astronomy, Nanoscale Science and Engineering Center, University of Georgia , Athens, Georgia 30602, United States.
authors.forename: Rui
authors.initials: R
authors.lastname: Cheng
authors.forename: Weijie
authors.initials: W
authors.lastname: Huang
authors.forename: Lijie
authors.initials: L
authors.lastname: Huang
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.forename: Leidong
authors.initials: L
authors.lastname: Mao
authors.forename: Kunlin
authors.initials: K
authors.lastname: Jin
authors.forename: Qichuan
authors.initials: Q
authors.lastname: ZhuGe
authors.forename: Yiping
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000818:Animals; D004058:Diffusion; D016503:Drug Delivery Systems / Q000295:instrumentation*; D005337:Fibrin / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D036103:Nanotechnology / Q000295:instrumentation*; D043942:Nanotubes; D012399:Rotation; D020521:Stroke / Q000188:drug therapy; D013927:Thrombosis / Q000188:drug therapy* / Q000378:metabolism; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use*
chemical_list: D005337:Fibrin; D010959:Tissue Plasminogen Activator