title: Assessment of myocardial partition coefficient of gadolinium (λ) in dilated cardiomyopathy and its impact on segmental and global systolic function.
abstract: OBJECTIVE
  1) To assess the myocardial partition coefficient (λ) of gadolinium quantified using T1 mapping in dilated cardiomyopathy (DCM); and 2) to assess the impact of increased λ on left ventricular (LV) circumferential strain and ejection fraction in DCM.
  
  
  METHODS
  Seventeen patients with DCM and 11 controls were prospectively included. All patients and controls underwent a 1.5 T MRI using: 1) cine to quantify LV volumes and function; 2) tagging to quantify circumferential strain in mid-LV; 3) T1 mapping before and 9 minutes after contrast injection to quantify R1, ΔR1, and λ; and 4) inversion recovery 3D Flash was used to assess late gadolinium enhancement (LGE) 10 minutes after Gd DOTA injection (0.2 mmol/kg). We used Student's t-test to compare means, Pearson's test for correlation assessment, and a mixed linear model to integrate the dependency between myocardial segments.
  
  
  RESULTS
  No difference in median λ was measured between patients with (0.52 [interquartile range = 0.48-0.56]) and without enhancement on LGE (0.51 [0.47-0.54]; P = 0.07). Circumferential strain value measured in each segment was correlated with the λ measured in the corresponding segment (r = 0.55; P < 0.0001). Multivariate analysis revealed a significant link between the λ in each segment and circumferential strain (0.002 ± 0.001; P = 0.009) and also with ejection fraction (-0.001 ± 0.0008; P = 0.04).
  
  
  CONCLUSIONS
  In DCM, λ correlates independently with circumferential strain and ejection fraction, suggesting that there is a link between λ and systolic function.
authors.affiliation: Department of Radiology, Aix Marseille Université, Hôpital Universitaire la Timone, Marseille, France; Centre de Résonance Magnétique Biologique et Médicale (CRMBM), UMR CNRS n° 6612, Aix Marseille Université, Faculté de Médecine de Marseille, Marseille, France.
authors.forename: Alexis
authors.initials: A
authors.lastname: Jacquier
authors.forename: Alexandros
authors.initials: A
authors.lastname: Kallifatidis
authors.forename: Nicolas
authors.initials: N
authors.lastname: Guibert
authors.forename: Roch
authors.initials: R
authors.lastname: Giorgi
authors.forename: Claire
authors.initials: C
authors.lastname: Falque
authors.forename: Franck
authors.initials: F
authors.lastname: Thuny
authors.forename: Pierre
authors.initials: P
authors.lastname: Croisille
authors.forename: Patrick
authors.initials: P
authors.lastname: Clarysse
authors.forename: Boris
authors.initials: B
authors.lastname: Maurel
authors.forename: Antonin
authors.initials: A
authors.lastname: Flavian
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Gaubert
authors.forename: Guy
authors.initials: G
authors.lastname: Moulin
authors.forename: Gilbert
authors.initials: G
authors.lastname: Habib
mesh_terms: D000368:Aged; D002311:Cardiomyopathy, Dilated / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism*; D019245:Compressive Strength; D003198:Computer Simulation; D003287:Contrast Media / Q000493:pharmacokinetics; D055119:Elastic Modulus; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008297:Male; D008536:Meglumine / Q000493:pharmacokinetics*; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D008955:Models, Cardiovascular; D009942:Organometallic Compounds / Q000493:pharmacokinetics*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical; D013318:Stroke Volume; D013718:Tensile Strength; D014018:Tissue Distribution; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism*
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D008536:Meglumine; C072417:gadoterate meglumine
keywords: MRI; contrast media; dilated cardiomyopathy; fibrosis; myocardium