title: [Ratio of erythrocyte and plasma in massive blood transfusion].
abstract: This study was purposed to explore the suitable ratio between fresh frozen plasma and erythrocyte by retrospective analysis of coagulation in patients with massive blood transfusion. The clinical data of 151 cases with massive blood transfusion from January 2011 to January 2013 were analyzed retrospectively. According to coagulation, patients were divided into coagulation normal group (138 cases) and coagulation dysfunction group (13 cases). Based on the ratio of 1:1 of fresh frozen plasma and erythrocyte, the patients were divided into high plasma group(2:1), medium plasma group (1:1) and low plasma (<1:1) subgroups. Coagulation was detected before and after 24 h of massive blood transfusion. The results showed that prothrombin time (PT), activated partial thromboplastin time (APTT) and thrombin time (TT) were prolonged, fibrinogen (FIB) level decreased significantly (all P < 0.05) in the low plasma subgroup of coagulation normal group after massive blood transfusion 24 h; the high plasma and the medium plasma group of coagulation normal group had no significant changes in coagulation (P > 0.05); prothrombin time, activated partial thromboplastin time, thrombin time and fibrinogen level in the medium plasma and low plasma subgroup of coagulation dysfunction group after massive transfusion was still in abnormal levels (P > 0.05), coagulation function in high plasma subgroup was improved significantly (P < 0.05). It is concluded that the ratio of plasma to erythrocyte should be adjusted according to the patient's coagulation function during massive blood transfusion, the ratio between fresh frozen plasma and erythrocyte is recommended to be 2:1 in patients of coagulation dysfunction in order to improve the patient's coagulation function and to reduce the incidence of adverse event, the ratio of fresh frozen plasma to erythrocyte is recommended to be 1:1 in patients with normal coagulation so as to reduce the dilutional coagulopathy and hypervolemia of blood.
authors.affiliation: Department of Blood Transfusion, The Third Xiangya Hospital of Central South University, Changsha 410013, Hunan Province, China.
authors.forename: Xian-Hui
authors.initials: XH
authors.lastname: Wen
authors.affiliation: Department of Blood Transfusion, The Third Xiangya Hospital of Central South University, Changsha 410013, Hunan Province, China.
authors.forename: Feng-Xia
authors.initials: FX
authors.lastname: Liu
authors.affiliation: Department of Blood Transfusion, The Third Xiangya Hospital of Central South University, Changsha 410013, Hunan Province, China.
authors.forename: Jun-Hua
authors.initials: JH
authors.lastname: Zhang
authors.affiliation: Department of Blood Transfusion, The Third Xiangya Hospital of Central South University, Changsha 410013, Hunan Province, China. E-mail:aguirong@163.com.
authors.forename: Rong
authors.initials: R
authors.lastname: Gui
mesh_terms: D000328:Adult; D000368:Aged; D001777:Blood Coagulation; D001778:Blood Coagulation Disorders / Q000517:prevention & control*; D001803:Blood Transfusion / Q000379:methods*; D004912:Erythrocytes; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010949:Plasma; D012189:Retrospective Studies; D065227:Transfusion Reaction; D055815:Young Adult