title: Heritability of epistaxis in the Australian Thoroughbred racehorse population.
abstract: Post exercise epistaxis, the manifestation of a severe form of exercise-induced pulmonary haemorrhage (EIPH), has been observed in many equine racing populations. Although multiple analyses have suggested that non-genetic factors may lead to the development of this condition, relatively little consensus has been reached regarding its genetic aetiology. The objective of this study was to provide insight into both genetic and non-genetic factors that may contribute to the expression of epistaxis in the Australian Thoroughbred racing population. Racing records and reported epistaxis occurrences were acquired for 117,088 horses entered in races and official barrier trials from 1 August 2000 until 22 February 2011. Heritability was estimated using two different logistic generalised linear mixed models (lifetime epistaxis risk h(2) = 0.27 and individual race epistaxis risk h(2) = 0.50). Sex, age, and year of birth were shown to be significant; however, trainer, jockey, race distance, condition of the track (i.e. 'going'), racecourse, track surface, number of race starters, year and month of race were not significant. Evidence suggests genetic and non-genetic links to EIPH expressed as epistaxis.
authors.affiliation: Faculty of Veterinary Science, University of Sydney, Camperdown, Sydney, New South Wales 2006, Australia. Electronic address: brandon.velie@sydney.edu.au.
authors.forename: B D
authors.initials: BD
authors.lastname: Velie
authors.affiliation: ReproGen-Animal Bioscience Group, Faculty of Veterinary Science, University of Sydney, Camden, New South Wales 2570, Australia.
authors.forename: H W
authors.initials: HW
authors.lastname: Raadsma
authors.affiliation: Faculty of Veterinary Science, University of Sydney, Camperdown, Sydney, New South Wales 2006, Australia.
authors.forename: C M
authors.initials: CM
authors.lastname: Wade
authors.affiliation: Discipline of Biomedical Science, Sydney Medical School, Lidcombe, New South Wales 2141, Australia.
authors.forename: P K
authors.initials: PK
authors.lastname: Knight
authors.affiliation: Faculty of Veterinary Science, University of Sydney, Camperdown, Sydney, New South Wales 2006, Australia.
authors.forename: N A
authors.initials: NA
authors.lastname: Hamilton
mesh_terms: D000818:Animals; D001315:Australia / Q000453:epidemiology; D004844:Epistaxis / Q000453:epidemiology / Q000235:genetics / Q000662:veterinary*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics*; D006734:Horse Diseases / Q000453:epidemiology / Q000235:genetics*; D006736:Horses; D016014:Linear Models; D016015:Logistic Models; D008297:Male
keywords: Epistaxis; Equine; Genetic; Haemorrhage; Heritability