title: Antidepressant effects of Radix et Caulis Acanthopanacis Santicosi extracts on rat models with depression in terms of immobile behavior.
abstract: OBJECTIVE
  To investigate the antidepressant effects of the Radix et Caulis Acanthopanacis Santicosi-extracts in response to the tail suspension test (TST) and forced swim test (FST) in rats.
  
  
  METHODS
  Male Wistar rats (9-week-old) were orally administered the Radix et Caulis Acanthopanacis Santicosi extracts (30, 100 and 300 mg/kg) daily for 14 consecutive days. Serum corticosterone level was measured by using commercially available kit. The c-fos immunoreactivity was analyzed using immunohistochemistry methods.
  
  
  RESULTS
  The effect of Radix et Caulis Acanthopanacis Santicosi extracts on the immobility time was significantly decreased at high-dose (300 mg/kg) treated group in the TST and FST (47.7% and 69.6%, p < 0.05), and decreased the hypothalamic-pituitary-adrenal (HPA) axis response to the stress, as indicated by an attenuated corticosterone response and decreased c-fos immunoreactivity in the hippocampal and hypothalamic paraventricular nucleus region.
  
  
  CONCLUSIONS
  Radix et Caulis Acanthopanacis Santicosi extracts have beneficial effects on depression behaviors and restore both altered c-fos expression and HPA activity. Thus, Radix et Caulis Acanthopanacis Santicosi extracts may be a novel agent for the treatment of stress-related disorders.
authors.forename: Bhaktaprasad
authors.initials: B
authors.lastname: Gaire
authors.forename: Dongwook
authors.initials: D
authors.lastname: Lim
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage*; D003863:Depression / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000523:psychology; D028001:Eleutherococcus / Q000737:chemistry*; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010936:Plant Extracts / Q000008:administration & dosage*; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013550:Swimming
chemical_list: D000928:Antidepressive Agents; D010936:Plant Extracts; D016760:Proto-Oncogene Proteins c-fos