title: Highly enantioselective synthesis of bisoxindoles with two vicinal quaternary stereocenters via Lewis base mediated addition of oxindoles to isatin-derived ketimines.
abstract: A highly efficient asymmetric organocatalytic addition of 3-substituted oxindole to isatin-derived ketimine is reported with excellent stereocontrol (>99 : 1 dr, >99% ee) under mild conditions. This method provides access to the bisoxindole structure moiety with two vicinal quaternary stereogenic centers.
authors.affiliation: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, P.R. China. cjzhu@nju.edu.cn wzheng@nju.edu.cn.
authors.forename: Zhongkai
authors.initials: Z
authors.lastname: Tang
authors.forename: Yan
authors.initials: Y
authors.lastname: Shi
authors.forename: Haibin
authors.initials: H
authors.lastname: Mao
authors.forename: Xuebin
authors.initials: X
authors.lastname: Zhu
authors.forename: Weipeng
authors.initials: W
authors.lastname: Li
authors.forename: Yixiang
authors.initials: Y
authors.lastname: Cheng
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Zheng
authors.forename: Chengjian
authors.initials: C
authors.lastname: Zhu