title: MicroRNA: important player in the pathobiology of multiple myeloma.
abstract: Recent studies have revealed a pivotal role played by a class of small, noncoding RNAs, microRNA (miRNA), in multiple myeloma (MM), a plasma cell (PC) malignancy causing significant morbidity and mortality. Deregulated miRNA expression in patient's PCs and plasma has been associated with tumor progression, molecular subtypes, clinical staging, prognosis, and drug response in MM. A number of important oncogenic and tumor suppressor miRNAs have been discovered to regulate important genes and pathways such as p53 and IL6-JAK-STAT signaling. miRNAs may also form complex regulatory circuitry with genetic and epigenetic machineries, the deregulation of which could lead to malignant transformation and progression. The translational potential of miRNAs in the clinic is being increasingly recognized that they could represent novel biomarkers and therapeutic targets. This review comprehensively summarizes current progress in delineating the roles of miRNAs in MM pathobiology and management.
authors.affiliation: Experimental Therapeutics, Cancer Science Institute of Singapore, No. 12-02, Centre for Translational Medicine, 14 Medical Drive, Singapore 117599 ; Yong Loo Lin School of Medicine, NUHS Tower Block level 11, 1E Kent Ridge Road, Singapore 119228.
authors.forename: Chonglei
authors.identifier: 0000-0002-9597-3985
authors.initials: C
authors.lastname: Bi
authors.affiliation: Experimental Therapeutics, Cancer Science Institute of Singapore, No. 12-02, Centre for Translational Medicine, 14 Medical Drive, Singapore 117599 ; Yong Loo Lin School of Medicine, NUHS Tower Block level 11, 1E Kent Ridge Road, Singapore 119228 ; Department of Hematology-Oncology, National University Cancer Institute, National University Health System, 1E, Kent Ridge Road, Singapore 119228.
authors.forename: Wee Joo
authors.initials: WJ
authors.lastname: Chng
mesh_terms: D063646:Carcinogenesis / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000096:biosynthesis / Q000235:genetics*; D009101:Multiple Myeloma / Q000235:genetics* / Q000503:physiopathology; D011379:Prognosis; D015398:Signal Transduction / Q000235:genetics
chemical_list: D035683:MicroRNAs