title: The CMYA5 gene confers risk for both schizophrenia and major depressive disorder in the Han Chinese population.
abstract: OBJECTIVE
  A recent genome-wide association study (GWAS) of the European population implicated the CMYA5 gene in schizophrenia. Previous functional studies showed that the CMYA5 protein can interact with DTNBP1 and PKA, providing further support for a role of CMYA5 in the pathogenesis of schizophrenia. However, this association requires additional validation in independent populations.
  
  
  METHODS
  To validate the association between CMYA5 and schizophrenia and major depressive disorder, we genotyped 16 SNPs within the CMYA5 gene and performed case-control studies in 1330 schizophrenia patients, 1045 patients with major depressive disorder, and 1235 normal controls. All patients were of Han Chinese origin.
  
  
  RESULTS
  rs6883197 and rs259127 were significantly associated with schizophrenia, and rs12514461, rs259127, and rs7343 were associated with major depressive disorder. Additionally, one risk haplotype of rs16877109-rs3828611 (G-G) was associated with both schizophrenia (P = 0.0000784, after correction) and major depressive disorder (P = 0.00230, after correction).
  
  
  CONCLUSIONS
  Our findings support the idea that specific alleles and haplotype in the CMYA5 confer genetic risk for both schizophrenia and major depressive disorder in the Han Chinese population.
authors.affiliation: Institute of Social Cognitive and Behavioral Sciences, Shanghai Jiao Tong University , Shanghai , PR China.
authors.forename: Qingzhong
authors.initials: Q
authors.lastname: Wang
authors.forename: Kuanjun
authors.initials: K
authors.lastname: He
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Li
authors.forename: Jianhua
authors.initials: J
authors.lastname: Chen
authors.forename: Wenjin
authors.initials: W
authors.lastname: Li
authors.forename: Zujia
authors.initials: Z
authors.lastname: Wen
authors.forename: Jiawei
authors.initials: J
authors.lastname: Shen
authors.forename: Yu
authors.initials: Y
authors.lastname: Qiang
authors.forename: Jue
authors.initials: J
authors.lastname: Ji
authors.forename: Yujiong
authors.initials: Y
authors.lastname: Wang
authors.forename: Yongyong
authors.initials: Y
authors.lastname: Shi
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D003865:Major Depressive Disorder / Q000235:genetics*; D005260:Female; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*
keywords: CMYA5; Han Chinese Population; case–control study; major depressive disorder; schizophrenia