title: NanoKeepers: stimuli responsive nanocapsules for programmed specific targeting and drug delivery.
abstract: Bacterial resistance is a high priority clinical issue worldwide. Thus, an effective system that rapidly provides specific treatment for bacterial infections using controlled dose release remains an unmet clinical need. Herein, we report on the NanoKeepers approach for the specific targeting of S. aureus with controlled release of antibiotics based on nuclease activity.
authors.affiliation: POLYMAT, University of Basque Country UPV/EHU, Avda. Tolosa 72, 20018 Donostia-San Sebastián, Spain. frank.hernandez@polymat.eu.
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Hernandez
authors.forename: Luiza I
authors.initials: LI
authors.lastname: Hernandez
authors.forename: Murat
authors.initials: M
authors.lastname: Kavruk
authors.forename: Yakup M
authors.initials: YM
authors.lastname: Arıca
authors.forename: Gülay
authors.initials: G
authors.lastname: Bayramoğlu
authors.forename: Baris A
authors.initials: BA
authors.lastname: Borsa
authors.forename: Hüseyin A
authors.initials: HA
authors.lastname: Öktem
authors.forename: Thomas
authors.initials: T
authors.lastname: Schäfer
authors.forename: Veli C
authors.initials: VC
authors.lastname: Özalp
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D008836:Micrococcal Nuclease / Q000378:metabolism; D008958:Models, Molecular; D008968:Molecular Conformation; D053769:Nanocapsules / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects; D013212:Staphylococcus epidermidis / Q000187:drug effects; D014640:Vancomycin / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D053769:Nanocapsules; D014640:Vancomycin; D008836:Micrococcal Nuclease