title: Association between single nucleotide polymorphisms of sterol regulatory element binding protein-2 and liver X receptor α gene and risk of polycystic ovary syndrome in a Chinese Han population.
abstract: To investigate associations of single nucleotide polymorphisms (SNPs) rs2228314 of sterol regulatory element-binding protein-2 (SREBP-2) or rs11039155 of liver X receptor α (LXRα) with susceptibility to polycystic ovary syndrome (PCOS) in a Chinese Han population. SREBP-2 rs2228314 and LXRα rs11039155 polymorphisms were genotyped in patients with PCOS and age- and sex-matched PCOS-free controls from a Chinese Han population. A total of 605 patients with PCOS and 615 controls were recruited in this study. We found that GC and CC genotypes of rs2228314, and variant C, were associated with a significantly increased risk of PCOS. In addition, GA and AA genotypes of rs11039155, as well as variant A, were also associated with a significantly increased risk of PCOS. Our results showed that SREBP-2 rs2228314 G to C change and variant C genotype as well as LXRα rs11039155 G to A change and variant A may contribute to PCOS in Chinese Han population.
authors.affiliation: Department of gynaecology and obstetrics, Hangzhou Red Cross Hospital, Hangzhou, 310003, Zhejiang Province, China.
authors.forename: Jianhong
authors.initials: J
authors.lastname: Zhao
authors.forename: Zhiying
authors.initials: Z
authors.lastname: Hu
authors.forename: Long
authors.initials: L
authors.lastname: Cai
authors.forename: Ling
authors.initials: L
authors.lastname: Liu
authors.forename: Xijing
authors.initials: X
authors.lastname: Jiang
authors.forename: Linzhen
authors.initials: L
authors.lastname: Wu
authors.forename: Junling
authors.initials: J
authors.lastname: Gong
mesh_terms: D000328:Adult; D044466:Asian People / Q000208:ethnology*; D016022:Case-Control Studies; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D000071518:Liver X Receptors; D008297:Male; D057093:Orphan Nuclear Receptors / Q000235:genetics*; D011085:Polycystic Ovary Syndrome / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D051782:Sterol Regulatory Element Binding Protein 2 / Q000235:genetics*
chemical_list: D000071518:Liver X Receptors; C000605213:NR1H3 protein, human; D057093:Orphan Nuclear Receptors; D051782:Sterol Regulatory Element Binding Protein 2