title: Nonionic surfactant vesicles in ocular delivery: innovative approaches and perspectives.
abstract: With the recent advancement in the field of ocular therapy, drug delivery approaches have been elevated to a new concept in terms of nonionic surfactant vesicles (NSVs), that is, the ability to deliver the therapeutic agent to a patient in a staggered profile. However the major drawbacks of the conventional drug delivery system like lacking of permeability through ocular barrier and poor bioavailability of water soluble drugs have been overcome by the emergence of NSVs. The drug loaded NSVs (DNSVs) can be fabricated by simple and cost-effective techniques with improved physical stability and enhance bioavailability without blurring the vision. The increasing research interest surrounding this delivery system has widened the areas of pharmaceutics in particular with many more subdisciplines expected to coexist in the near future. This review gives a comprehensive emphasis on NSVs considerations, formulation approaches, physicochemical properties, fabrication techniques, and therapeutic significances of NSVs in the field of ocular delivery and also addresses the future development of modified NSVs.
authors.affiliation: Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.
authors.forename: Ranjan Ku
authors.initials: RK
authors.lastname: Sahoo
authors.affiliation: Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.
authors.forename: Nikhil
authors.initials: N
authors.lastname: Biswas
authors.affiliation: Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.
authors.forename: Arijit
authors.initials: A
authors.lastname: Guha
authors.affiliation: Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.
authors.forename: Nityananda
authors.initials: N
authors.lastname: Sahoo
authors.affiliation: Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.
authors.forename: Ketousetuo
authors.identifier: 0000-0003-2548-5289
authors.initials: K
authors.lastname: Kuotsu
mesh_terms: D016503:Drug Delivery Systems; D065546:Drug Liberation; D005128:Eye Diseases / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008081:Liposomes / Q000008:administration & dosage / Q000737:chemistry; D013501:Surface-Active Agents / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D008081:Liposomes; D013501:Surface-Active Agents