title: Piper species protect cardiac, hepatic and renal antioxidant status of atherogenic diet fed hamsters.
abstract: Pre-clinical and clinical studies points to the use of antioxidants as an effective measure to reduce the progression of oxidative stress related disorders. The present study evaluate the effect of three Piper species (Piper guineense, Piper nigrum and Piper umbellatum) for the protection of cardiac, hepatic and renal antioxidant status of atherogenic diet fed hamsters. Hamsters were classified into eight groups: a normal control, atherogenic control and six other experimental groups (fed atherogenic diet supplemented with different doses of P. nigrum, P. guineense and P. umbellatum (1 and 0.25 g/kg) for 12 weeks. At the end of the feeding period the heart, liver and kidney from each group were analyzed for lipid profile and antioxidant enzymes activities. Atherogenic diet induced a significant (P<0.001) increase in the lipid profile across the board and equally significantly altered the antioxidant enzyme activities. Supplementation with Piper species significantly inhibited the alteration effect of atherogenic diet on the lipid profile and antioxidant enzymes activities. The Piper extracts may possess an antioxidant protective role against atherogenic diet induced oxidative stress in cardiac, hepatic and renal tissues.
authors.affiliation: Department of Chemistry, University of Scranton, 800 Linden St., PA 18510, USA; Institute of Medical Research and Medicinal Plants Studies, P.O. Box 6163, Yaoundé, Cameroon.
authors.forename: Gabriel A
authors.initials: GA
authors.lastname: Agbor
authors.affiliation: Institute of Medical Research and Medicinal Plants Studies, P.O. Box 6163, Yaoundé, Cameroon.
authors.forename: Luli
authors.initials: L
authors.lastname: Akinfiresoye
authors.affiliation: Institute of Medical Research and Medicinal Plants Studies, P.O. Box 6163, Yaoundé, Cameroon.
authors.forename: Julianne
authors.initials: J
authors.lastname: Sortino
authors.affiliation: Institute of Medical Research and Medicinal Plants Studies, P.O. Box 6163, Yaoundé, Cameroon.
authors.forename: Robert
authors.initials: R
authors.lastname: Johnson
authors.affiliation: Institute of Medical Research and Medicinal Plants Studies, P.O. Box 6163, Yaoundé, Cameroon.
authors.forename: Joe A
authors.initials: JA
authors.lastname: Vinson
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D050197:Atherosclerosis / Q000139:chemically induced / Q000188:drug therapy*; D006224:Cricetinae; D004036:Diet, Atherogenic / Q000009:adverse effects*; D006321:Heart / Q000187:drug effects*; D007668:Kidney / Q000187:drug effects*; D008055:Lipids / Q000032:analysis; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects; D031701:Piper / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D008055:Lipids; D010936:Plant Extracts