title: Hemoglobin A1c for diagnosis of postpartum abnormal glucose tolerance among women with gestational diabetes mellitus: diagnostic meta-analysis.
abstract: OBJECTIVE
  To evaluate the accuracy of glycosylated hemoglobin A1c (HbA1c) for the diagnosis of postpartum abnormal glucose tolerance among women with gestational diabetes mellitus (GDM).
  
  
  METHODS
  After a systematic review of related studies, the sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and other measures about the accuracy of HbA1c in the diagnosis of postpartum abnormal glucose tolerance were pooled using random-effects models. The summary receiver operating characteristic (SROC) curve was used to summarize the overall test performance.
  
  
  RESULTS
  Six studies met our inclusion criteria. The pooled results on SEN, SPE, PLR, NLR, and DOR were 0.36 (95% CI 0.23-0.52), 0.85 (95% CI 0.73-0.92), 2.4 (95% CI 1.6-3.6), 0.75 (95% CI 0.63-0.88) and 3 (95% CI 2-5). The area under the summary receiver operating characteristic (SROC) curve was 0.67 with a Q value of 0.63.
  
  
  CONCLUSIONS
  Measurement of HbA1c alone is not a sensitive test to detect abnormal glucose tolerance in women with prior GDM.
authors.affiliation: Department of Endocrinology, Liaocheng People's Hospital, Liaocheng, China.
authors.forename: Xudong
authors.initials: X
authors.lastname: Su
authors.affiliation: Department of Gynaecology and Obstetrics, Women and Children Hospital, Liaocheng, China.
authors.forename: Zhaoyan
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Gynaecology and Obstetrics, Women and Children Hospital, Liaocheng, China.
authors.forename: Xinye
authors.initials: X
authors.lastname: Qu
authors.affiliation: Department of Endocrinology, Liaocheng People's Hospital, Liaocheng, China.
authors.forename: Yaqiang
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Department of Endocrinology, Liaocheng People's Hospital, Liaocheng, China.
authors.forename: Guangzhen
authors.initials: G
authors.lastname: Zhang
mesh_terms: D000328:Adult; D019540:Area Under Curve; D001786:Blood Glucose / Q000378:metabolism; D016640:Diabetes, Gestational / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D018149:Glucose Intolerance / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D015233:Models, Statistical; D049590:Postpartum Period; D011247:Pregnancy; D012372:ROC Curve
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human