title: Batch and continuous flow preparation of Hantzsch 1,4-dihydropyridines under microwave heating and simultaneous real-time monitoring by Raman spectroscopy. An exploratory study.
abstract: Dialkyl 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylates have been prepared in a batch mode under conventional heating as well as under continuous flow conditions in the Miniflow 200SS, Sairem's microwave-assisted batch and continuous flow equipment. Real-time monitoring of the reactions by Raman spectroscopy enabled to compare both heating modes and to determine (optimized) reaction times.
authors.affiliation: Laboratory of Organic Chemistry, University of Mons-UMONS, 23 Place du Parc, B-7000 Mons, Belgium. spit06@hotmail.com.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Christiaens
authors.affiliation: Laboratory of Organic Chemistry, University of Mons-UMONS, 23 Place du Parc, B-7000 Mons, Belgium. mxiano@hotmail.com.
authors.forename: Xavier
authors.initials: X
authors.lastname: Vantyghem
authors.affiliation: SAIREM SAS, 12 porte du Grand Lyon, F-01702 Neyron, France. mradoiu@sairem.com.
authors.forename: Marilena
authors.initials: M
authors.lastname: Radoiu
authors.affiliation: Laboratory of Organic Chemistry, University of Mons-UMONS, 23 Place du Parc, B-7000 Mons, Belgium. jean-jacques.vandeneynde@ex.umons.ac.
authors.forename: Jean Jacques
authors.initials: JJ
authors.lastname: Vanden Eynde
mesh_terms: D004095:Dihydropyridines / Q000138:chemical synthesis / Q000737:chemistry*; D006361:Heating; D006358:Hot Temperature; D008872:Microwaves; D012997:Solvents; D013059:Spectrum Analysis, Raman / Q000295:instrumentation / Q000379:methods
chemical_list: D004095:Dihydropyridines; D012997:Solvents; C038806:1,4-dihydropyridine