title: Roles of ligands from the TNF superfamily in B cell development, function, and regulation.
abstract: Most ligands from the tumour necrosis factor (TNF) superfamily play very important roles in the immune system, and particularly so in B lymphocyte biology. TNF ligands are essential to many aspects of normal B cell biology from development in the bone marrow to maturation in the periphery as well as for activation and differentiation into germinal centre, memory or plasma cells. TNF ligands also influence other aspects of B cell biology such as their ability to present antigens or regulate immune responses. Importantly, inadequate regulation of many TNF ligands is associated with B cell disorders including autoimmunity and cancers. As a result, inhibitors of a number of TNF ligands have been tested in the clinic, with some becoming very successful approved treatments alleviating B cell-mediated pathologies.
authors.affiliation: Department of Immunology, Monash University, Central Clinical School, Alfred Medical Research and Education Precinct (AMREP), Commercial Road, Melbourne, Victoria 3004, Australia.
authors.forename: William A
authors.initials: WA
authors.lastname: Figgett
authors.affiliation: Department of Immunology, Monash University, Central Clinical School, Alfred Medical Research and Education Precinct (AMREP), Commercial Road, Melbourne, Victoria 3004, Australia.
authors.forename: Fabien B
authors.initials: FB
authors.lastname: Vincent
authors.affiliation: Department of Immunology, Monash University, Central Clinical School, Alfred Medical Research and Education Precinct (AMREP), Commercial Road, Melbourne, Victoria 3004, Australia.
authors.forename: Damien
authors.initials: D
authors.lastname: Saulep-Easton
authors.affiliation: Department of Immunology, Monash University, Central Clinical School, Alfred Medical Research and Education Precinct (AMREP), Commercial Road, Melbourne, Victoria 3004, Australia. Electronic address: Fabienne.Mackay@monash.edu.
authors.forename: Fabienne
authors.initials: F
authors.lastname: Mackay
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology; D001402:B-Lymphocytes / Q000166:cytology* / Q000276:immunology* / Q000378:metabolism; D002470:Cell Survival; D006801:Humans; D013601:T-Lymphocytes / Q000276:immunology; D048069:Tumor Necrosis Factors / Q000145:classification / Q000378:metabolism*
chemical_list: D048069:Tumor Necrosis Factors
keywords: Autoimmunity; B cells; Cancer; TNF superfamily