title: Comparison of the outcomes of photodynamic therapy between two angiographic subtypes of polypoidal choroidal vasculopathy.
abstract: BACKGROUND
  To compare the outcomes of photodynamic therapy (PDT) between two different angiographic subtypes of polypoidal choroidal vasculopathy (PCV).
  
  
  METHODS
  Ninety-three consecutive cases of PCV were classified into two phenotypes (42 type 1 and 51 type 2) according to the presence or absence of feeding vessels found on indocyanine green angiography. Full-dose PDT and retreatments were performed every 3 months as needed based on the findings on angiography. The best-corrected visual acuity (BCVA) was compared as the main outcome between type 1 and type 2 PCV up to 12 months after the initial PDT.
  
  
  RESULTS
  The baseline greatest linear dimension (GLD) was significantly larger in type 1 PCV than type 2 PCV. The mean BCVA was significantly improved from baseline in type 2 PCV, while no improvement was found in type 1 PCV. Analysis with matching the GLD between both PCV subtypes did not change the original results.
  
  
  CONCLUSIONS
  There may be a significantly different response to PDT between two angiographic phenotypes of PCV.
authors.affiliation: Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Honda
authors.forename: Akiko
authors.initials: A
authors.lastname: Miki
authors.forename: Suiho
authors.initials: S
authors.lastname: Yanagisawa
authors.forename: Wataru
authors.initials: W
authors.lastname: Matsumiya
authors.forename: Takayuki
authors.initials: T
authors.lastname: Nagai
authors.forename: Yasutomo
authors.initials: Y
authors.lastname: Tsukahara
mesh_terms: D000368:Aged; D020256:Choroidal Neovascularization / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy*; D004396:Coloring Agents; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D010778:Photochemotherapy; D011127:Polyps / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green