title: Preoperative comorbidities as potential risk factors for venous thromboembolism after joint arthroplasty: a systematic review and meta-analysis of cohort and case-control studies.
abstract: The purpose of this study was to examine the effect of preoperative comorbidities on the risk of VTE after joint arthroplasty surgery. Of 2235 citations identified for screening, 16 studies reporting 7,395,847 patients were eligible. The results showed that patients with cardiovascular disease, previous VTE history, neurologic disease and high anesthetic ASA rating had significantly higher VTE risk than those with no such preexisting medical comorbidities after joint arthroplasty. The presence of respiratory disease, urinary and kidney disease, coronary artery disease, endocrine disease, cancer and malignant disease, hematological disease and comorbidities index did not increase the risk of VTE in our study. The data suggest that risk assessment of patients may further reduce the overall incidence of DVT and PE from VTE prophylaxis.
authors.affiliation: Department of Orthopaedic Surgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zeng
authors.affiliation: Department of Orthopaedic Surgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Shen
authors.affiliation: Department of Orthopaedic Surgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Orthopaedic Surgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Zongke
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: Department of Orthopaedic Surgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Pengde
authors.initials: P
authors.lastname: Kang
authors.affiliation: Department of Orthopaedic Surgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Fuxing
authors.initials: F
authors.lastname: Pei
mesh_terms: D001178:Arthroplasty / Q000009:adverse effects*; D016022:Case-Control Studies; D015331:Cohort Studies; D015897:Comorbidity; D006801:Humans; D015994:Incidence; D018570:Risk Assessment; D012307:Risk Factors; D054556:Venous Thromboembolism / Q000453:epidemiology* / Q000209:etiology
keywords: comorbidity; joint arthroplasty; pulmonary embolism; risk factors; venous thromboembolism; venous thrombosis