title: The effect of STDP temporal kernel structure on the learning dynamics of single excitatory and inhibitory synapses.
abstract: Spike-Timing Dependent Plasticity (STDP) is characterized by a wide range of temporal kernels. However, much of the theoretical work has focused on a specific kernel - the "temporally asymmetric Hebbian" learning rules. Previous studies linked excitatory STDP to positive feedback that can account for the emergence of response selectivity. Inhibitory plasticity was associated with negative feedback that can balance the excitatory and inhibitory inputs. Here we study the possible computational role of the temporal structure of the STDP. We represent the STDP as a superposition of two processes: potentiation and depression. This allows us to model a wide range of experimentally observed STDP kernels, from Hebbian to anti-Hebbian, by varying a single parameter. We investigate STDP dynamics of a single excitatory or inhibitory synapse in purely feed-forward architecture. We derive a mean-field-Fokker-Planck dynamics for the synaptic weight and analyze the effect of STDP structure on the fixed points of the mean field dynamics. We find a phase transition along the Hebbian to anti-Hebbian parameter from a phase that is characterized by a unimodal distribution of the synaptic weight, in which the STDP dynamics is governed by negative feedback, to a phase with positive feedback characterized by a bimodal distribution. The critical point of this transition depends on general properties of the STDP dynamics and not on the fine details. Namely, the dynamics is affected by the pre-post correlations only via a single number that quantifies its overlap with the STDP kernel. We find that by manipulating the STDP temporal kernel, negative feedback can be induced in excitatory synapses and positive feedback in inhibitory. Moreover, there is an exact symmetry between inhibitory and excitatory plasticity, i.e., for every STDP rule of inhibitory synapse there exists an STDP rule for excitatory synapse, such that their dynamics is identical.
authors.affiliation: Department of Physiology and Cell Biology, Faculty of Health Sciences Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors.forename: Yotam
authors.initials: Y
authors.lastname: Luz
authors.affiliation: Department of Physiology and Cell Biology, Faculty of Health Sciences Ben-Gurion University of the Negev, Beer-Sheva, Israel; Department of Physics, Faculty of Natural Sciences Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors.forename: Maoz
authors.initials: M
authors.lastname: Shamir
mesh_terms: D019706:Excitatory Postsynaptic Potentials; D025461:Feedback, Physiological; D053444:Inhibitory Postsynaptic Potentials; D007858:Learning / Q000502:physiology*; D008959:Models, Neurological; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000166:cytology*; D013569:Synapses / Q000502:physiology*