title: Acute hepatic injury with atorvastatin: an unusual occurrence.
abstract: Atorvastatin, a commonly used and well-tolerated hypolipidemic drug, belongs to the class of statins or hydroxymethylglutaryl-coenzyme A reductase inhibitors. Use of atorvastatin may be associated with minor asymptomatic elevations in serum aminotransferases, but clinically significant hepatotoxicity is usually infrequent. Here we present a case of self-limiting clinically apparent acute hepatic injury attributable to atorvastatin occurring at recommended daily dose of 20 mg once a day. This case was postulated to be an unusual idiosyncratic reaction of the drug.
authors.affiliation: Department of Pharmacology, LLRM Medical College, Meerut, Uttar Pradesh, India.
authors.forename: Pinki
authors.initials: P
authors.lastname: Vishwakarma
authors.affiliation: Department of Biochemistry, LLRM Medical College, Meerut, Uttar Pradesh, India.
authors.forename: Rajiv
authors.initials: R
authors.lastname: Nehra
authors.affiliation: Forensic Medicine and Toxicology, RIMS and R, Saifai, Etawah, Uttar Pradesh, India.
authors.forename: Alok
authors.initials: A
authors.lastname: Kumar
mesh_terms: D000069059:Atorvastatin; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D006538:Heptanoic Acids / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D006949:Hyperlipidemias / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011758:Pyrroles / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011758:Pyrroles; D000069059:Atorvastatin
keywords: Acute hepatotoxicity; aminotransferase enzymes; atorvastatin