title: Silicone lymphadenopathy: presentation of a further case containing asteroid bodies on fine-needle cytology sample.
abstract: Silicone lymphadenopathy is a recognized complication of breast augmentation. It is thought to occur when silicone droplets migrate from breast implants to lymph nodes. We report the cytologic findings in axillary and inguinal lymph node aspirate smears from a 35-year-old Italian woman, who came to our observation 10 years after bilateral cosmetic breast augmentation. A fine-needle cytology of the axillary lymph node showed extensive granulomatous inflammation, numerous histiocytes, and multinucleated giant cells containing star-shaped structures known as "asteroid bodies." The inguinal lymph node aspirate simply showed an aspecific reactive hyperplasia. No evidence of malignancy was present in any of the smears as well as in the excised axillary lymph node.
authors.affiliation: Istituto Nazionale Tumori "Fondazione G. Pascale", SSD di Citopatologia, S.C di Anatomia Patologica.
authors.forename: Maria Gabriella
authors.initials: MG
authors.lastname: Malzone
authors.forename: Anna Cipolletta
authors.initials: AC
authors.lastname: Campanile
authors.forename: Antonella
authors.initials: A
authors.lastname: Gioioso
authors.forename: Alfredo
authors.initials: A
authors.lastname: Fucito
authors.forename: Giuseppe
authors.initials: G
authors.lastname: D'Aiuto
authors.forename: Gerardo
authors.initials: G
authors.lastname: Botti
authors.forename: Franco
authors.initials: F
authors.lastname: Fulciniti
mesh_terms: D000328:Adult; D044963:Biopsy, Fine-Needle; D019928:Breast Implantation / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008206:Lymphatic Diseases / Q000209:etiology / Q000473:pathology*; D020034:Silicone Gels / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D020034:Silicone Gels
keywords: asteroid bodies; breast augmentation; fine-needle cytology; lymph node; silicone lymphadenopathy