title: pH responsive supramolecular prodrug micelles based on cucurbit[8]uril for intracellular drug delivery.
abstract: The first attempt of constructing pH responsive supramolecular prodrug micelles based on cucurbit[8]uril is reported. The obtained prodrug micelles are found to be able to inhibit proliferation of cancer cells. It is anticipated that this facile strategy may open a novel avenue for the development of multifunctional drug delivery systems.
authors.affiliation: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China. jinqiao@zju.edu.cn jijian@zju.edu.cn.
authors.forename: Yin
authors.initials: Y
authors.lastname: Wang
authors.forename: Dandan
authors.initials: D
authors.lastname: Li
authors.forename: Haibo
authors.initials: H
authors.lastname: Wang
authors.forename: Yangjun
authors.initials: Y
authors.lastname: Chen
authors.forename: Haijie
authors.initials: H
authors.lastname: Han
authors.forename: Qiao
authors.initials: Q
authors.lastname: Jin
authors.forename: Jian
authors.initials: J
authors.lastname: Ji
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000494:pharmacology; D001952:Bridged-Ring Compounds / Q000008:administration & dosage* / Q000737:chemistry; D004317:Doxorubicin / Q000008:administration & dosage / Q000494:pharmacology; D004337:Drug Carriers; D006863:Hydrogen-Ion Concentration; D007093:Imidazoles / Q000008:administration & dosage* / Q000737:chemistry; D008823:Micelles; D046529:Microscopy, Electron, Transmission; D011355:Prodrugs / Q000008:administration & dosage* / Q000737:chemistry; D066244:Proton Magnetic Resonance Spectroscopy; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils
chemical_list: D000903:Antibiotics, Antineoplastic; D001952:Bridged-Ring Compounds; D004317:Doxorubicin; D004337:Drug Carriers; D007093:Imidazoles; D008823:Micelles; D011355:Prodrugs; C507198:cucurbit(8)uril; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils