title: Acanthosis nigricans, vitamin D, and insulin resistance in obese children and adolescents.
abstract: OBJECTIVE
  The aim of this study is to identify factors accounting for the variation in 25-hydroxyvitamin D levels in a pediatric obese population.
  
  
  METHODS
  One hundred and forty-nine obese children and adolescents (BMI ≥95th percentile) were evaluated in a pediatric endocrine office. Acanthosis nigricans (AN) skin lesions were rated on a 4-point scale.
  
  
  RESULTS
  The 25-hydroxyvitamin D levels were significantly different between those without AN and those with any severity of AN (p=<0.001). Insulin levels were only significantly different between those with no and severe AN (p=0.007). A general linear model showed that month of visit predicted 19.0% of the variation and AN an additional 2.2%. When AN was dropped from the full model, log-transformed HOMA-IR remained insignificant (p=0.164).
  
  
  CONCLUSIONS
  Season of evaluation was the main determinant of 25-hydroxyvitamin D levels. Severity of AN was a stronger predictor of 25-hydroxyvitamin D level variation than the measure of insulin resistance HOMA-IR.
authors.forename: Arnold H
authors.initials: AH
authors.lastname: Slyper
authors.forename: Laurissa
authors.initials: L
authors.lastname: Kashmer
authors.forename: Wei-Min
authors.initials: WM
authors.lastname: Huang
authors.forename: Yochai
authors.initials: Y
authors.lastname: Re'em
mesh_terms: D000052:Acanthosis Nigricans / Q000097:blood* / Q000473:pathology; D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D008297:Male; D009765:Obesity / Q000097:blood* / Q000473:pathology; D011379:Prognosis; D012189:Retrospective Studies; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014815:Vitamins / Q000097:blood*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D014815:Vitamins; D014807:Vitamin D; C104450:25-hydroxyvitamin D