title: Fluorescent sensors using DNA-functionalized graphene oxide.
abstract: In the past few years, graphene oxide (GO) has emerged as a unique platform for developing DNA-based biosensors, given the DNA adsorption and fluorescence-quenching properties of GO. Adsorbed DNA probes can be desorbed from the GO surface in the presence of target analytes, producing a fluorescence signal. In addition to this initial design, many other strategies have been reported, including the use of aptamers, molecular beacons, and DNAzymes as probes, label-free detection, utilization of the intrinsic fluorescence of GO, and the application of covalently linked DNA probes. The potential applications of DNA-functionalized GO range from environmental monitoring and cell imaging to biomedical diagnosis. In this review, we first summarize the fundamental surface interactions between DNA and GO and the related fluorescence-quenching mechanism. Following that, the various sensor design strategies are critically compared. Problems that must be overcome before this technology can reach its full potential are described, and a few future directions are also discussed.
authors.affiliation: School of Pharmaceutical Sciences, Central South University, Changsha, 410013, Hunan, China.
authors.forename: Zhenbao
authors.initials: Z
authors.lastname: Liu
authors.forename: Biwu
authors.initials: B
authors.lastname: Liu
authors.forename: Jinsong
authors.initials: J
authors.lastname: Ding
authors.forename: Juewen
authors.initials: J
authors.lastname: Liu
mesh_terms: D000327:Adsorption; D004247:DNA / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry*
chemical_list: D005456:Fluorescent Dyes; D010087:Oxides; D006108:Graphite; D004247:DNA