title: Angina symptom burden associated with depression status among veterans with ischemic heart disease.
abstract: BACKGROUND
  Angina and depression are common in ischemic heart disease (IHD), but their association remains understudied.
  
  
  OBJECTIVE
  This study was conducted in order to evaluate the association of 1 year change in depression with change in patient-reported outcomes of stable angina.
  
  
  METHODS
  Five hundred sixty-nine stable angina patients completed the Seattle Angina Questionnaire and Patient Health Questionnaire (PHQ) at baseline and 1 year. Participants were divided into four groups: not depressed, new onset of depression at 1 year, remitted at 1 year, and persistently depressed. Associations between depression and angina symptoms were evaluated using regression models.
  
  
  RESULTS
  Compared to those not depressed, newly depressed participants reported more angina (β = -11.7, p < 0.001) and physical limitations (β = -11.8, p < 0.001) and lower treatment satisfaction (β = -15.03, p < 0.001) and quality of life (β = -15.4, p < 0.001). Persistently depressed participants reported physical limitations (β = -7.4, p < 0.05), lower treatment satisfaction (β = -10.1, p < 0.001), and poorer quality of life (β = -10.03, p < 0.001).
  
  
  CONCLUSIONS
  Changes in depression scores and angina outcomes were significantly associated.
authors.affiliation: VA Puget Sound Health Care System, Seattle, WA, USA, ranak.trivedi@va.gov.
authors.forename: Ranak
authors.initials: R
authors.lastname: Trivedi
authors.forename: Martha
authors.initials: M
authors.lastname: Gerrity
authors.forename: John S
authors.initials: JS
authors.lastname: Rumsfeld
authors.forename: John A
authors.initials: JA
authors.lastname: Spertus
authors.forename: Haili
authors.initials: H
authors.lastname: Sun
authors.forename: Mary
authors.initials: M
authors.lastname: McDonell
authors.forename: Melanie
authors.initials: M
authors.lastname: Doak
authors.forename: Linda
authors.initials: L
authors.lastname: Lucas
authors.forename: Stephan D
authors.initials: SD
authors.lastname: Fihn
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000787:Angina Pectoris / Q000150:complications / Q000175:diagnosis*; D017281:Cost of Illness; D003863:Depression / Q000150:complications / Q000175:diagnosis*; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications*; D011788:Quality of Life; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D063189:Symptom Assessment; D014728:Veterans