title: Genetic association analysis of CNR1 and CNR2 polymorphisms with schizophrenia in a Korean population.
abstract: Located on 6q15 and 1p36.11, cannabinoid receptor 1 (CNR1) and cannabinoid receptor 2 (CNR2) genes are considered to be a positional and functional candidate gene for the development of mental disorders such as schizophrenia because CNR1 is known as a regulator of dopamine signaling in the hippocampus and the cerebral cortex. However, few genetic studies have been carried out to investigate an association of CNR1 and CNR2 polymorphisms and the risk of schizophrenia. In this study, although the result indicates that CNR1 and CNR2 variations are unlikely to influence schizophrenia susceptibility in a Korean population, the findings would provide meaningful information for further genetic studies.
authors.affiliation: aLaboratory of Translational Genomics, Samsung Genome Institute, Samsung Medical Center bLaboratory of Genomic Diversity, Department of Life Science cDepartment of Genetic Epidemiology, SNP Genetics Inc., Sogang University dDepartment of General Psychiatry, Seoul National Hospital eDepartment of Neuropsychiatry, Soonchunhyang University Hospital, Seoul fDepartment of Psychiatry, College of Medicine, Gyeongsang National University, Gyeongsang Nam Do gDepartment of Biomedical Engineering, Yonsei University, Wonju, Republic of Korea hResearch Institute for Basic Science, Sogang University, Shinsu-dong, Mapo-gu, Seoul, 121-742, Republic of Korea.
authors.forename: Joon Seol
authors.initials: JS
authors.lastname: Bae
authors.forename: Jason Yongha
authors.initials: JY
authors.lastname: Kim
authors.forename: Byung-Lae
authors.initials: BL
authors.lastname: Park
authors.forename: Jeong-Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Bomi
authors.initials: B
authors.lastname: Kim
authors.forename: Chul Soo
authors.initials: CS
authors.lastname: Park
authors.forename: Bong-Jo
authors.initials: BJ
authors.lastname: Kim
authors.forename: Cheol-Soon
authors.initials: CS
authors.lastname: Lee
authors.forename: Migyung
authors.initials: M
authors.lastname: Lee
authors.forename: Woo Hyuk
authors.initials: WH
authors.lastname: Choi
authors.forename: Tae-Min
authors.initials: TM
authors.lastname: Shin
authors.forename: Jaeuk
authors.initials: J
authors.lastname: Hwang
authors.forename: Hyoung Doo
authors.initials: HD
authors.lastname: Shin
authors.forename: Sung-Il
authors.initials: SI
authors.lastname: Woo
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020161:Physical Chromosome Mapping; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D043884:Receptor, Cannabinoid, CB1 / Q000235:genetics*; D043885:Receptor, Cannabinoid, CB2 / Q000235:genetics*; D056910:Republic of Korea; D012559:Schizophrenia / Q000235:genetics*; D055815:Young Adult
chemical_list: C571130:CNR1 protein, human; C588309:CNR2 protein, human; D043884:Receptor, Cannabinoid, CB1; D043885:Receptor, Cannabinoid, CB2