title: Triterpene lactones from cultures of Ganoderma sp. KM01.
abstract: A revised structure of colossolactone G (1), seven new triterpene lactones, ganodermalactones A-G (2-8), and five known triterpene lactones, colossolactone I (9), schisanlactone B (10), colossolactone B (11), colossolactone E (12), and colossolactone IV (13), and ergosterol have been isolated from cultured biomass of the macrofungi Ganoderma sp. KM01. Their structures were identified by spectroscopic methods. Structures and relative configurations of 3, 7, and 8 were confirmed by X-ray crystallographic analysis. Compounds 7, 10, and 12 exhibited antimalarial activity against Plasmodium falciparum in the range 6.0-10.0 μM (IC50).
authors.affiliation: Natural Products Research Unit, Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, KhonKaen University , KhonKaen 40002, Thailand.
authors.forename: Waranya
authors.initials: W
authors.lastname: Lakornwong
authors.forename: Kwanjai
authors.initials: K
authors.lastname: Kanokmedhakul
authors.forename: Somdej
authors.initials: S
authors.lastname: Kanokmedhakul
authors.forename: Palangpon
authors.initials: P
authors.lastname: Kongsaeree
authors.forename: Samran
authors.initials: S
authors.lastname: Prabpai
authors.forename: Phoutthasone
authors.initials: P
authors.lastname: Sibounnavong
authors.forename: Kasem
authors.initials: K
authors.lastname: Soytong
mesh_terms: D000962:Antimalarials / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D032902:Ganoderma / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification*; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010963:Plasmodium falciparum / Q000187:drug effects*; D013785:Thailand; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000962:Antimalarials; D007783:Lactones; D014315:Triterpenes; C000591551:colossolactone G