title: De novo computer-aided design of novel antiviral agents.
abstract: Computer-aided drug design techniques have become an integral part of the drug discovery process. In particular, de novo methodologies can be useful to identify putative ligands for a specific target relying only on the structural information of the target itself. Here we discuss the basic de novo approaches available and their application in antiviral drug design.:
authors.affiliation: Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Drug and Food Biotechnology Center, Università degli Studi del Piemonte Orientale A. Avogadro Via Bovio 6, 28100 Novara, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Massarotti
authors.affiliation: Istituto Pasteur - Fondazione Cenci Bolognetti, Dipartimento di Chimica e Tecnologie del Farmaco Sapienza Università di Roma Piazzale Aldo Moro 5, I-00185 Roma, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Coluccia
authors.affiliation: Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Drug and Food Biotechnology Center, Università degli Studi del Piemonte Orientale A. Avogadro Via Bovio 6, 28100 Novara, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Sorba
authors.affiliation: Istituto Pasteur - Fondazione Cenci Bolognetti, Dipartimento di Chimica e Tecnologie del Farmaco Sapienza Università di Roma Piazzale Aldo Moro 5, I-00185 Roma, Italy.
authors.forename: Romano
authors.initials: R
authors.lastname: Silvestri
authors.affiliation: The Welsh School of Pharmacy, Cardiff University King Edward VII Avenue, Cardiff, CF10 3NB, UK. Electronic address:brancalea@cardiff.ac.uk.
authors.forename: Andrea
authors.initials: A
authors.lastname: Brancale