title: Pradofloxacin: a novel veterinary fluoroquinolone for treatment of bacterial infections in cats.
abstract: Pradofloxacin is a novel third-generation oral veterinary fluoroquinolone with activity against Gram-positive aerobic bacteria and anaerobes (lower minimum inhibitory concentrations in vitro). It also has activity against other bacterial species, including Bartonella henselae, Pasteurella multocida, Bordetella bronchiseptica, extra-intestinal Escherichia coli, and some mycobacterial species. This review focuses on the current knowledge of the mechanism of action, adverse effects, clinical applications, and pharmacokinetic/pharmacodynamic properties of pradofloxacin in cats.
authors.affiliation: Department of Medicine and Epidemiology, 2108 Tupper Hall, University of California, Davis, Davis, CA 95616, USA. Electronic address: jesykes@ucdavis.edu.
authors.forename: Jane E
authors.initials: JE
authors.lastname: Sykes
authors.affiliation: Departments of Pathology and Laboratory Medicine, Microbiology and Immunology and Ophthalmology, Royal University Hospital, Saskatoon Health Region and University of Saskatchewan, Saskatoon, Saskatchewan S7N 0W8, Canada.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Blondeau
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology*; D001424:Bacterial Infections / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D002371:Cat Diseases / Q000188:drug therapy* / Q000382:microbiology; D002415:Cats; D024841:Fluoroquinolones / Q000009:adverse effects / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; C507250:pradofloxacin
keywords: Antimicrobial; Minimum inhibitory concentration; Pharmacodynamics; Pharmacokinetics; Resistance