title: Tuberous sclerosis presenting with acute kidney failure, pyelonephritis, and polycystic kidney disease.
abstract: Tuberous sclerosis complex (TSC) is a multisystemic inherited autosomal dominant disease characterized by the development of hamartomas in the brain and kidneys. In about 2% of patients, polycystic kidney disease is present, which may result in different stages of renal insufficiency. Acute kidney failure has not been reported in infants with TSC. We report a female infant with TSC who was admitted to hospital with pyelonephritis, acute kidney injury, and polycystic kidney disease.
authors.affiliation: Pediatric Nephrology Research Center; Division of Pediatric Nephrology, Shahid Beheshti University of Medical Sciences; Tehran, Iran. mohkam@pirc.ir.
authors.forename: Masoumeh
authors.initials: M
authors.lastname: Mohkam
authors.forename: Shirin
authors.initials: S
authors.lastname: Shohadaii
authors.forename: Farshid
authors.initials: F
authors.lastname: Kompani
authors.forename: Hamid Reza
authors.initials: HR
authors.lastname: Aghadoost
authors.forename: Seyed Ali
authors.initials: SA
authors.lastname: Hojati
authors.forename: Nasrin
authors.initials: N
authors.lastname: Esfandiar
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D004927:Escherichia coli Infections / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006801:Humans; D017496:Hypopigmentation / Q000150:complications; D007223:Infant; D016891:Polycystic Kidney, Autosomal Dominant / Q000150:complications*; D011704:Pyelonephritis / Q000188:drug therapy / Q000382:microbiology*; D014402:Tuberous Sclerosis / Q000150:complications*
chemical_list: D000900:Anti-Bacterial Agents