title: TRAF4 participates in Wnt/β-catenin signaling in breast cancer by upregulating β-catenin and mediating its translocation to the nucleus.
abstract: Tumor necrosis factor receptor-associated factor 4 (TRAF4) is upregulated in various subtypes of breast cancers and cell lines; however, the precise functions of TRAF4 are poorly understood. Our objective was to investigate its relationship with β-catenin. TRAF4 participates in several signaling pathways, such as NF-κB and JNK signaling pathways. In this study, we identified β-catenin as a TRAF4-binding protein, have shown that TRAF4 enhanced expression of β-catenin, and found that TRAF4 mediated the translocation of β-catenin from the cytoplasm to the nucleus, thereby facilitating activation of the Wnt signaling pathway in breast cancer.
authors.affiliation: Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, North 2nd Road 92, Heping Ward, 110001, Shenyang, China.
authors.forename: Ailian
authors.initials: A
authors.lastname: Wang
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.forename: Huanyan
authors.initials: H
authors.lastname: Ren
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.forename: Lili
authors.initials: L
authors.lastname: Sun
authors.forename: Kexin
authors.initials: K
authors.lastname: Diao
authors.forename: Zhijuan
authors.initials: Z
authors.lastname: Zhao
authors.forename: Min
authors.initials: M
authors.lastname: Song
authors.forename: Zeshi
authors.initials: Z
authors.lastname: Cui
authors.forename: Enhua
authors.initials: E
authors.lastname: Wang
authors.forename: Minjie
authors.initials: M
authors.lastname: Wei
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Mi
mesh_terms: D021581:Active Transport, Cell Nucleus; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism*; D045744:Cell Line, Tumor; D002467:Cell Nucleus / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D061986:MCF-7 Cells; D053449:TNF Receptor-Associated Factor 4 / Q000235:genetics / Q000378:metabolism*; D015854:Up-Regulation; D060449:Wnt Signaling Pathway; D051176:beta Catenin / Q000378:metabolism*
chemical_list: C495270:CTNNB1 protein, human; D053449:TNF Receptor-Associated Factor 4; C506367:TRAF4 protein, human; D051176:beta Catenin