title: Survival of patients with cystic fibrosis on ECMO: analysis of the Extracorporeal Life Support Organization Registry.
abstract: Progressive respiratory failure is a common cause of death in patients with cystic fibrosis (CF). Although this may be related to the disease process itself, acute infectious problems may lead to respiratory failure requiring mechanical ventilation. Given the progressive nature of the disorder, some have suggested that the use of extracorporeal membrane oxygenation (ECMO) is contraindicated. The current study retrospectively reviewed the Extracorporeal Life Support Organization (ELSO) Registry to evaluate the outcomes following the use of ECMO in patients with CF. A total of 73 ECMO runs were identified in CF patients. There were 33 who received VV ECMO, 32 on VA ECMO, and 8 who received combined VA and VA ECMO. The overall survival rate for the cohort was 52% (38 of 73 patients). There was no difference in survival when comparing VA and VV ECMO. We noted an increasing trend for VV ECMO for this patient population over this time period. These data further support the need for a prospective study to evaluate outcomes following ECMO in this population with standardization of care across multiple centers.
authors.affiliation: Department of Pediatrics, The Ohio State University College of Medicine, Section of Pulmonary Medicine, Nationwide Children's Hospital Columbus, OH, USA.
authors.forename: Don
authors.initials: D
authors.lastname: Hayes
authors.affiliation: Department of Pediatrics, The Ohio State University College of Medicine, Section of Pulmonary Medicine, Nationwide Children's Hospital Columbus, OH, USA.
authors.forename: Benjamin T
authors.initials: BT
authors.lastname: Kopp
authors.affiliation: Department of Cardiovascular Perfusion, Heart Center, Nationwide Children's Hospital Columbus, OH, USA.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Preston
authors.affiliation: Department of Pediatrics, The Ohio State University College of Medicine, Section of Pulmonary Medicine, Nationwide Children's Hospital Columbus, OH, USA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Kirkby
authors.affiliation: Department of Anesthesiology & Pain Medicine, Nationwide Children's Hospital Columbus, OH, USA ; Department of Anesthesiology, The Ohio State University College of Medicine Columbus, OH, USA.
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Tobias
authors.affiliation: Department of Anesthesiology, The Ohio State University College of Medicine Columbus, OH, USA.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Papadimos
authors.affiliation: Department of Surgery, The Ohio State University College of Medicine Columbus, OH, USA.
authors.forename: Bryan A
authors.initials: BA
authors.lastname: Whitson
keywords: Cystic fibrosis; extracorporeal membrane oxygenation; survival; venoarterial; venovenous