title: Pharmacological attenuation of myocardial reperfusion injury in a closed-chest porcine model: a systematic review.
abstract: Myocardial ischemia-reperfusion injury is a clinical challenge in interventional cardiology, and at the moment, no pharmacological agent is universally accepted in the prevention. In order to prevent inappropriate clinical trials, a potential pharmacological agent should be proved reproducibly effective in clinically relevant experimental studies before initiation of human studies. The closed-chest porcine model is a promising experimental model of ischemia-reperfusion injury. The purpose of this systematic review was to describe the pharmacological treatments evaluated in the closed-chest porcine model and discuss different aspects of the model for future use. The systematic review was performed according to the PRISMA guidelines.
authors.affiliation: Department of Surgery, Herlev Hospital, University of Copenhagen, Herlev Ringvej 75, 2730, Herlev, Denmark, sarahekeloef@gmail.com.
authors.forename: Sarah
authors.initials: S
authors.lastname: Ekeløf
authors.forename: Jacob
authors.initials: J
authors.lastname: Rosenberg
authors.forename: Jan Skov
authors.initials: JS
authors.lastname: Jensen
authors.forename: Ismail
authors.initials: I
authors.lastname: Gögenur
mesh_terms: D000818:Animals; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D013552:Swine; D016896:Treatment Outcome
chemical_list: D002317:Cardiovascular Agents