title: The brainstem pathologies of Parkinson's disease and dementia with Lewy bodies.
abstract: Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are among the human synucleinopathies, which show alpha-synuclein immunoreactive neuronal and/or glial aggregations and progressive neuronal loss in selected brain regions (eg, substantia nigra, ventral tegmental area, pedunculopontine nucleus). Despite several studies about brainstem pathologies in PD and DLB, there is currently no detailed information available regarding the presence of alpha-synuclein immunoreactive inclusions (i) in the cranial nerve, precerebellar, vestibular and oculomotor brainstem nuclei and (ii) in brainstem fiber tracts and oligodendroctyes. Therefore, we analyzed the inclusion pathologies in the brainstem nuclei (Lewy bodies, LB; Lewy neurites, LN; coiled bodies, CB) and fiber tracts (LN, CB) of PD and DLB patients. As reported in previous studies, LB and LN were most prevalent in the substantia nigra, ventral tegmental area, pedunculopontine and raphe nuclei, periaqueductal gray, locus coeruleus, parabrachial nuclei, reticular formation, prepositus hypoglossal, dorsal motor vagal and solitary nuclei. Additionally we were able to demonstrate LB and LN in all cranial nerve nuclei, premotor oculomotor, precerebellar and vestibular brainstem nuclei, as well as LN in all brainstem fiber tracts. CB were present in nearly all brainstem nuclei and brainstem fiber tracts containing LB and/or LN. These findings can contribute to a large variety of less well-explained PD and DLB symptoms (eg, gait and postural instability, impaired balance and postural reflexes, falls, ingestive and oculomotor dysfunctions) and point to the occurrence of disturbances of intra-axonal transport processes and transneuronal spread of the underlying pathological processes of PD and DLB along anatomical pathways.
authors.affiliation: Dr. Senckenbergisches Chronomedizinisches Institute, J.W. Goethe University, Frankfurt/Main, Germany.
authors.forename: Kay
authors.initials: K
authors.lastname: Seidel
authors.forename: Josefine
authors.initials: J
authors.lastname: Mahlke
authors.forename: Sonny
authors.initials: S
authors.lastname: Siswanto
authors.forename: Reijko
authors.initials: R
authors.lastname: Krüger
authors.forename: Helmut
authors.initials: H
authors.lastname: Heinsen
authors.forename: Georg
authors.initials: G
authors.lastname: Auburger
authors.forename: Mohamed
authors.initials: M
authors.lastname: Bouzrou
authors.forename: Lea T
authors.initials: LT
authors.lastname: Grinberg
authors.forename: Helmut
authors.initials: H
authors.lastname: Wicht
authors.forename: Horst-Werner
authors.initials: HW
authors.lastname: Korf
authors.forename: Wilfred
authors.initials: W
authors.lastname: den Dunnen
authors.forename: Udo
authors.initials: U
authors.lastname: Rüb
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001933:Brain Stem / Q000378:metabolism / Q000473:pathology*; D020541:Coiled Bodies / Q000473:pathology; D005260:Female; D006801:Humans; D016631:Lewy Bodies / Q000473:pathology; D020961:Lewy Body Disease / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D009836:Oligodendroglia / Q000378:metabolism / Q000473:pathology; D010300:Parkinson Disease / Q000378:metabolism / Q000473:pathology*; D051844:alpha-Synuclein / Q000378:metabolism
chemical_list: D051844:alpha-Synuclein
keywords: Parkinson's disease; alpha-synuclein; brainstem; dementia with Lewy bodies; prion-like disease