title: No expression of porcine endogenous retrovirus after pig to monkey xenotransplantation.
abstract: This study was performed to investigate the expression of two porcine endogenous retrovirus (PERV) elements, PERV gag and full-length conserved PERV, in blood cells collected periodically from organ-recipient monkeys that underwent pig to non-human primate xenotransplantation. The heart and kidney-respectively acquired from α-1,3-galactosyltransferase knockout (GT-KO) pigs that survived for24 and 25 days-were xenografted into cynomolgus monkeys. The two PERV elements expressed in the xenografted GT-KO pig organs were not present in the blood cells of the recipient monkeys. In the present study, we deduced that PERVs are not transmitted during GT-KO pig to monkey xenotransplantation.
authors.affiliation: National Institute of Animal Science, Suwon, Korea.
authors.forename: Seongsoo
authors.initials: S
authors.lastname: Hwang
authors.affiliation: Pusan National University, Busan, Korea.
authors.forename: Yi-Deun
authors.initials: YD
authors.lastname: Jung
authors.affiliation: Orient Genia Inc., Seongnam, Korea.
authors.forename: Kahee
authors.initials: K
authors.lastname: Cho
authors.affiliation: National Institute of Animal Science, Suwon, Korea.
authors.forename: Sun-A
authors.initials: SA
authors.lastname: Ock
authors.affiliation: National Institute of Animal Science, Suwon, Korea.
authors.forename: Keon-Bong
authors.initials: KB
authors.lastname: Oh
authors.affiliation: Pusan National University, Busan, Korea.
authors.forename: Heui-Soo
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Ik-Jin
authors.initials: IJ
authors.lastname: Yun
authors.affiliation: Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Curie
authors.initials: C
authors.lastname: Ahn
authors.affiliation: National Institute of Animal Science, Suwon, Korea.
authors.forename: Jin-Ki
authors.initials: JK
authors.lastname: Park
authors.affiliation: National Institute of Animal Science, Suwon, Korea.
authors.forename: Seoki
authors.initials: S
authors.lastname: Im
keywords: GT-KO pigs; PERV transmission; blood cells; cynomolgus monkey; xenotransplantation