title: Morphological changes in the suprachiasmatic nucleus of aging female marmosets (Callithrix jacchus).
abstract: The suprachiasmatic nuclei (SCN) are pointed to as the mammals central circadian pacemaker. Aged animals show internal time disruption possibly caused by morphological and neurochemical changes in SCN components. Some studies reported changes of neuronal cells and neuroglia in the SCN of rats and nonhuman primates during aging. The effects of senescence on morphological aspects in SCN are important for understanding some alterations in biological rhythms expression. Therefore, our aim was to perform a comparative study of the morphological aspects of SCN in adult and aged female marmoset. Morphometric analysis of SCN was performed using Nissl staining, NeuN-IR, GFAP-IR, and CB-IR. A significant decrease in the SCN cells staining with Nissl, NeuN, and CB were observed in aged female marmosets compared to adults, while a significant increase in glial cells was found in aged marmosets, thus suggesting compensatory process due to neuronal loss evoked by aging.
authors.affiliation: Laboratory of Neurochemical Studies, Physiology Department, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
authors.forename: Rovena Clara G J
authors.initials: RC
authors.lastname: Engelberth
authors.affiliation: Laboratory of Neurochemical Studies, Physiology Department, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
authors.forename: Kayo Diogenes de A
authors.initials: KD
authors.lastname: Silva
authors.affiliation: Laboratory of Chronobiology, Physiology Department, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
authors.forename: Carolina V de M
authors.initials: CV
authors.lastname: Azevedo
authors.affiliation: Behavioral Pharmacology Laboratory, Department of Biophysics and Pharmacology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
authors.forename: Elaine Cristina
authors.initials: EC
authors.lastname: Gavioli
authors.affiliation: Biology Department, Federal University of Sergipe, Aracaju, SE, Brazil.
authors.forename: Jose Ronaldo
authors.initials: JR
authors.lastname: dos Santos
authors.affiliation: Laboratory of Neuroanatomy, Morphology Department, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
authors.forename: Joacil Germano
authors.initials: JG
authors.lastname: Soares
authors.affiliation: Laboratory of Neuroanatomy, Morphology Department, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
authors.forename: Expedito S
authors.initials: ES
authors.lastname: Nascimento Junior
authors.affiliation: Laboratory of Neuroanatomy, Morphology Department, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
authors.forename: Judney C
authors.initials: JC
authors.lastname: Cavalcante
authors.affiliation: Laboratory of Neuroanatomy, Morphology Department, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
authors.forename: Miriam Stela M O
authors.initials: MS
authors.lastname: Costa
authors.affiliation: Laboratory of Neurochemical Studies, Physiology Department, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
authors.forename: Jeferson S
authors.initials: JS
authors.lastname: Cavalcante
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D002144:Callithrix; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D008297:Male; D051381:Rats; D013493:Suprachiasmatic Nucleus / Q000166:cytology / Q000254:growth & development*