title: Thematic minireview series on phospholipase D and cancer.
abstract: Phospholipase D (PLD) signaling plays a critical role in cell growth and proliferation, vesicular trafficking, secretion, and endocytosis. At the cellular level, PLD and its reaction product, phosphatidate, interact with a large number of protein partners that are directly related to the actin cytoskeleton and cell migration. Cancer invasion and metastasis rely heavily on cellular motility, and as such, they have put PLD at center stage in cancer research. This minireview series highlights some of the molecular mechanisms that provide evidence for the emerging tumorigenic potential of PLD, the role of the microenvironment, and putative connections with inflammation. PLD represents a potential target for the rational development of therapeutics against cancer and other diseases.
authors.affiliation: Department of Biochemistry and Molecular Biology, Wright State University School Medicine, Dayton, Ohio 45435 and. Electronic address: julian.cambronero@wright.edu.
authors.forename: Julian
authors.initials: J
authors.lastname: Gomez-Cambronero
authors.affiliation: Department of Food Science, Rutgers Center for Lipid Research, and New Jersey Institute for Food, Nutrition, and Health, Rutgers University, New Brunswick, New Jersey 08901. Electronic address: carman@aesop.rutgers.edu.
authors.forename: George M
authors.initials: GM
authors.lastname: Carman
mesh_terms: D008841:Actin Cytoskeleton / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D000818:Animals; D002465:Cell Movement; D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000473:pathology / Q000628:therapy; D010739:Phospholipase D / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D059016:Tumor Microenvironment
chemical_list: D009363:Neoplasm Proteins; D010739:Phospholipase D
keywords: Cancer; Inflammation; Lipid Signaling; Phosphatidate; Phospholipase D