title: Genomic complexity and IGHV mutational status are key predictors of outcome of chronic lymphocytic leukemia patients with TP53 disruption.
authors.affiliation: Department of Hematology, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona jdelgado@clinic.ub.es sbea@clinic.cat.
authors.forename: Julio
authors.initials: J
authors.lastname: Delgado
authors.affiliation: Hematopathology Unit, Hospital Clínic, IDIBAPS, Barcelona.
authors.forename: Itziar
authors.initials: I
authors.lastname: Salaverria
authors.affiliation: Department of Hematology, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona.
authors.forename: Tycho
authors.initials: T
authors.lastname: Baumann
authors.affiliation: Hematopathology Unit, Hospital Clínic, IDIBAPS, Barcelona.
authors.forename: Alejandra
authors.initials: A
authors.lastname: Martínez-Trillos
authors.affiliation: Hematopathology Unit, Hospital Clínic, IDIBAPS, Barcelona.
authors.forename: Eriong
authors.initials: E
authors.lastname: Lee
authors.affiliation: Hematopathology Unit, Hospital Clínic, IDIBAPS, Barcelona.
authors.forename: Laura
authors.initials: L
authors.lastname: Jiménez
authors.affiliation: Hematopathology Unit, Hospital Clínic, IDIBAPS, Barcelona.
authors.forename: Alba
authors.initials: A
authors.lastname: Navarro
authors.affiliation: Hematopathology Unit, Hospital Clínic, IDIBAPS, Barcelona.
authors.forename: Cristina
authors.initials: C
authors.lastname: Royo
authors.affiliation: Department of Hematology, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Santacruz
authors.affiliation: Hematopathology Unit, Hospital Clínic, IDIBAPS, Barcelona.
authors.forename: Cristina
authors.initials: C
authors.lastname: López
authors.affiliation: Department of Hematology, Hospital Central de Asturias, Oviedo.
authors.forename: Angel R
authors.initials: AR
authors.lastname: Payer
authors.affiliation: Department of Hematology, Hospital Central de Asturias, Oviedo.
authors.forename: Enrique
authors.initials: E
authors.lastname: Colado
authors.affiliation: Department of Hematology, Hospital Clínico, Salamanca.
authors.forename: Marcos
authors.initials: M
authors.lastname: González
authors.affiliation: qGenomics Laboratories, Barcelona, Spain.
authors.forename: Lluís
authors.initials: L
authors.lastname: Armengol
authors.affiliation: Hematopathology Unit, Hospital Clínic, IDIBAPS, Barcelona.
authors.forename: Dolors
authors.initials: D
authors.lastname: Colomer
authors.affiliation: Hematopathology Unit, Hospital Clínic, IDIBAPS, Barcelona.
authors.forename: Magda
authors.initials: M
authors.lastname: Pinyol
authors.affiliation: Hematopathology Unit, Hospital Clínic, IDIBAPS, Barcelona.
authors.forename: Neus
authors.initials: N
authors.lastname: Villamor
authors.affiliation: Hematopathology Unit, Hospital Clínic, IDIBAPS, Barcelona.
authors.forename: Marta
authors.initials: M
authors.lastname: Aymerich
authors.affiliation: Hematopathology Unit, Hospital Clínic, IDIBAPS, Barcelona.
authors.forename: Ana
authors.initials: A
authors.lastname: Carrió
authors.affiliation: Hematopathology Unit, Hospital Clínic, IDIBAPS, Barcelona.
authors.forename: Dolors
authors.initials: D
authors.lastname: Costa
authors.affiliation: Hematopathology Unit, Hospital Clínic, IDIBAPS, Barcelona.
authors.forename: Guillem
authors.initials: G
authors.lastname: Clot
authors.affiliation: Department of Hematology, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona.
authors.forename: Eva
authors.initials: E
authors.lastname: Giné
authors.affiliation: Department of Hematology, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona.
authors.forename: Armando
authors.initials: A
authors.lastname: López-Guillermo
authors.affiliation: Hematopathology Unit, Hospital Clínic, IDIBAPS, Barcelona.
authors.forename: Elías
authors.initials: E
authors.lastname: Campo
authors.affiliation: Hematopathology Unit, Hospital Clínic, IDIBAPS, Barcelona.
authors.forename: Sílvia
authors.initials: S
authors.lastname: Beà
mesh_terms: D018740:Genetic Heterogeneity; D023281:Genomics; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007135:Immunoglobulin Variable Region / Q000235:genetics*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics* / Q000401:mortality*; D009154:Mutation; D011379:Prognosis; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region; D016159:Tumor Suppressor Protein p53
keywords: 17p deletion; CLL; CN-arrays; IGHV; TP53; genome complexity