title: Relationship of ghrelin, acid uric and proinflammatory adipocytokines in different degrees of obesity or diabetes.
abstract: We compared and examined factors associated with ghrelin and uric acid in obese subjects (OB), obese plus type 2 diabetes mellitus (OBDM) and healthy controls (C). Methods. We analyzed blood count, renal function, liver enzymes, lipids, resistin, leptin, IL-6, uric acid and ghrelin in OB, OBDM and C. We included 76 subjects with different body mass index (BMI): 36 C (24 ± 3), 11 OB<40 (30-39.9), 20 OB>40 (40-60), and 9 OBDM (45.9 ± 9). Results. Metabolic profile was as follows: HOMA-IR 4.7 ± 3 and 5 ± 3 vs 2 ± 1 (p < 0.01), resistin 8.7 ± 2 and 9.4 ± 2 vs 5.4 ± 2 ng/mL (p < 0.001), leptin 6.2 ± 3.9 and 5.3 ± 2 vs 3.6 ± 1.8 ng/mL (p = 0.001) and IL-6 197.5 ± 78.9 and 223.6 ± 115 vs 7.4 ± 8.3 pg/mL (p = 0.001) in OB and OBDM vs C, respectively. Ghrelin was higher in OB<40 compared to C (1780 ± 197 vs 1465 ± 12 pg/mL, p < 0.05), and lower in OBDM (987.4 ± 114 pg/mL, p < 0.05). BMI showed a positive correlation with resistin (p < 0.001); leptin (p = 0.004), IL-6 (p = 0.001), uric acid (p = 0.0005) and negative with ghrelin (r = -0.431, p = 0.028). Resistin was directly correlated with leptin (p < 0.001) and inversely correlated with renal function (p = 0.03). Conclusion. Severe obesity and obesity-associated diabetes affected ghrelin and uric acid levels. This may well be associated with proinflammatory adipocytokines, insulin resistance, liver enzymes or renal function.
authors.affiliation: División de Investigación, Hospital de Especialidades, Centro Médico La Raza Mexico, DF, Mexico.
authors.forename: María Pilar
authors.initials: MP
authors.lastname: Cruz-Domínguez
authors.affiliation: División de Investigación, Hospital de Especialidades, Centro Médico La Raza Mexico, DF, Mexico.
authors.forename: Daniel H Montes
authors.initials: DH
authors.lastname: Cortés
authors.affiliation: Unidad de Investigación Médica en Enfermedades Endocrinas, CMN, IMSS México, DF, México.
authors.forename: Arturo
authors.initials: A
authors.lastname: Zarate
authors.affiliation: Endocrinología, Hospital de Especialidades, Centro Médico La Raza Mexico, DF, Mexico.
authors.forename: María de Los Ángeles
authors.initials: Mde L
authors.lastname: Tapia-González
authors.affiliation: División de Investigación, Hospital de Especialidades, Centro Médico La Raza Mexico, DF, Mexico.
authors.forename: Sandra
authors.initials: S
authors.lastname: Alvarez-Acosta
authors.affiliation: Unidad de Investigación Médica en Enfermedades Endocrinas, CMN, IMSS México, DF, México.
authors.forename: Leticia
authors.initials: L
authors.lastname: Damasio
authors.affiliation: Unidad de Investigación Médica en Enfermedades Endocrinas, CMN, IMSS México, DF, México.
authors.forename: Leticia
authors.initials: L
authors.lastname: Manuel-Apolinar
keywords: Obesity; adipocytokines; diabetes; ghrelin; uric acid