title: Effect of oral isotretinoin treatment on retinal nerve fiber layer thickness.
abstract: BACKGROUND
  Oral isotretinoin treatment can cause ocular side effects.
  
  
  OBJECTIVE
  This study was performed to detect possible toxic effects of oral isotretinoin treatment on the retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL).
  
  
  METHODS
  The study population consisted of 54 eyes of 27 patients with nodulocystic acne who used oral isotretinoin (Roaccutane) treatment. Macular GCL and peripapillary RNFL thickness measurements were performed using spectral domain optical coherence tomography (OCT) before and after therapy.
  
  
  RESULTS
  Before and after treatment, a complete ophthalmologic examination was normal in all eyes. However, posttreatment lower temporal (TL) values were significantly lower (76.80 ± 16.31) than pretreatment TL values (84.96 ± 24.83) (p  =  .02). There was no statistically significant difference in the other OCT values, upper temporal, superotemporal, superonasal, upper nasal, lower nasal, inferonasal, and inferotemporal (p  =  .35, p  =  .40, p  =  .56, p  =  .95, p  =  .94, p  =  .93, p  =  .61, respectively). Also, there was no statistically significant difference between the right and left eyes and between genders for all parameters (p > .05).
  
  
  CONCLUSIONS
  The use of oral isotretinoin treatment has increased in recent years. In addition, oral isotretinoin treatment has a broad adverse effect potential on the ocular system. The measurement of RNFL thickness, especially TL thickness, by OCT may be useful for detecting the possible toxic effect of oral isotretinoin therapy on RNFL.
authors.forename: Haydar
authors.initials: H
authors.lastname: Ucak
authors.forename: Veysel
authors.initials: V
authors.lastname: Aykut
authors.forename: Savas
authors.initials: S
authors.lastname: Ozturk
authors.forename: Demet
authors.initials: D
authors.lastname: Cicek
authors.forename: Ilker
authors.initials: I
authors.lastname: Erden
authors.forename: Betul
authors.initials: B
authors.lastname: Demir
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000284:Administration, Oral; D000328:Adult; D003879:Dermatologic Agents / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D015474:Isotretinoin / Q000008:administration & dosage*; D008297:Male; D009412:Nerve Fibers / Q000187:drug effects* / Q000473:pathology; D009900:Optic Nerve / Q000187:drug effects* / Q000473:pathology; D012160:Retina / Q000187:drug effects* / Q000473:pathology; D012165:Retinal Ganglion Cells / Q000187:drug effects / Q000473:pathology; D041623:Tomography, Optical Coherence; D055815:Young Adult
chemical_list: D003879:Dermatologic Agents; D015474:Isotretinoin