title: Maintenance of amyloid β peptide homeostasis by artificial chaperones based on mixed-shell polymeric micelles.
abstract: The disruption of Aβ homeostasis, which results in the accumulation of neurotoxic amyloids, is the fundamental cause of Alzheimer's disease (AD). Molecular chaperones play a critical role in controlling undesired protein misfolding and maintaining intricate proteostasis in vivo. Inspired by a natural molecular chaperone, an artificial chaperone consisting of mixed-shell polymeric micelles (MSPMs) has been devised with tunable surface properties, serving as a suppressor of AD. Taking advantage of biocompatibility, selectivity toward aberrant proteins, and long blood circulation, these MSPM-based chaperones can maintain Aβ homeostasis by a combination of inhibiting Aβ fibrillation and facilitating Aβ aggregate clearance and simultaneously reducing Aβ-mediated neurotoxicity. The balance of hydrophilic/hydrophobic moieties on the surface of MSPMs is important for their enhanced therapeutic effect.
authors.affiliation: Key Laboratory of Functional Polymer Materials, Ministry of Education, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Institute of Polymer Chemistry, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, (P.R. China), Institution.
authors.forename: Fan
authors.initials: F
authors.lastname: Huang
authors.forename: Jianzu
authors.initials: J
authors.lastname: Wang
authors.forename: Aoting
authors.initials: A
authors.lastname: Qu
authors.forename: Liangliang
authors.initials: L
authors.lastname: Shen
authors.forename: Jinjian
authors.initials: J
authors.lastname: Liu
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Liu
authors.forename: Zhenkun
authors.initials: Z
authors.lastname: Zhang
authors.forename: Yingli
authors.initials: Y
authors.lastname: An
authors.forename: Linqi
authors.initials: L
authors.lastname: Shi
mesh_terms: D016229:Amyloid beta-Peptides / Q000737:chemistry*; D002942:Circular Dichroism; D006706:Homeostasis; D007700:Kinetics; D008823:Micelles; D046529:Microscopy, Electron, Transmission; D018832:Molecular Chaperones / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D016229:Amyloid beta-Peptides; D008823:Micelles; D018832:Molecular Chaperones; D011108:Polymers
keywords: Alzheimer’s disease; amyloid β peptide; artificial chaperones; homeostasis; polymeric micelles