title: Predictive value of early amplitude-integrated electroencephalography for later diagnosed cerebral white matter damage in preterm infants.
abstract: OBJECTIVE
  The aim of the article is to assess the predictive value of amplitude-integrated electroencephalogram (aEEG) for cerebral white matter damage (WMD) in preterm infants. Patients and
  
  
  METHODS
  Preterms ≤ 32 weeks' gestational age (GA) born between March 2012 and December 2012 were enrolled. The aEEG patterns within 72 hours were classified and recorded to predict their neurodevelopmental prognosis and the predictive results were used to compare with the results by cerebral ultrasound examination. Neurobehavioral disorder (neonatal behavioral neurological assessment score < 35, dyskinesia or dysgnosia) or death was thought as poor neurodevelopmental prognosis. Psychomotor development index (PDI) or mental development index (MDI) ≤ 79 was regarded as dyskinesia or dysgnosia, respectively.
  
  
  RESULTS
  Of the 63 preterms, 3.2% were born < 27 weeks' gestation and 96.8% at 27 to 32 weeks' gestation. The median GA was 29.3 weeks and the median birth weight was 1,030 g. On the basis of the aEEG results, normal, mildly abnormal, and severely abnormal cases were 10, 24, and 29; whereas determined by cerebral ultrasound, normal, mild, and severe cases were 17, 20, and 26, respectively. The aEEG degree showed significantly positive correlations with both WMD and poor neurodevelopmental prognosis (p < 0.01).
  
  
  CONCLUSIONS
  Abnormal aEEG of preterm infants within 72 hours after birth may imply WMD occurrence and poor neurodevelopmental prognosis.
authors.affiliation: Department of Pediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Song
authors.affiliation: Department of Pediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Changlian
authors.initials: C
authors.lastname: Zhu
authors.affiliation: Department of Pediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Falin
authors.initials: F
authors.lastname: Xu
authors.affiliation: Department of Pediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Jiajia
authors.initials: J
authors.lastname: Guo
authors.affiliation: Department of Pediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D058256:Brain Waves / Q000502:physiology*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000473:pathology*; D004569:Electroencephalography; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000175:diagnosis*; D056784:Leukoencephalopathies / Q000175:diagnosis*; D008297:Male; D009460:Neurologic Examination; D011237:Predictive Value of Tests; D013223:Statistics as Topic; D014463:Ultrasonography