title: TFAA/H3PO4 mediated unprecedented N-acylation of carbazoles leading to small molecules possessing anti-proliferative activities against cancer cells.
abstract: For the first time TFAA/H3PO4 has facilitated the direct and metal-free N-acylation of carbazoles leading to a number of N-acylated derivatives. Several of these compounds were found to be promising when tested for their anti-proliferative properties against oral cancer cell lines.
authors.affiliation: Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur 522510, A.P., India.
authors.forename: Sunder Kumar
authors.initials: SK
authors.lastname: Kolli
authors.forename: Bagineni
authors.initials: B
authors.lastname: Prasad
authors.forename: P Vijaya
authors.initials: PV
authors.lastname: Babu
authors.forename: Mohd Ashraf
authors.initials: MA
authors.lastname: Ashfaq
authors.forename: Nasreen Z
authors.initials: NZ
authors.lastname: Ehtesham
authors.forename: R Ramesh
authors.initials: RR
authors.lastname: Raju
authors.forename: Manojit
authors.initials: M
authors.lastname: Pal
mesh_terms: D000089:Acetic Anhydrides / Q000737:chemistry*; D000215:Acylation; D002227:Carbazoles / Q000494:pharmacology*; D002264:Carboxylic Acids / Q000737:chemistry; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005463:Fluoroacetates / Q000737:chemistry*; D057809:HEK293 Cells; D006801:Humans; D009369:Neoplasms / Q000473:pathology*; D010756:Phosphoric Acids / Q000737:chemistry*; D054852:Small Molecule Libraries / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism
chemical_list: D000089:Acetic Anhydrides; D002227:Carbazoles; D002264:Carboxylic Acids; D005463:Fluoroacetates; D010756:Phosphoric Acids; D054852:Small Molecule Libraries; C017958:trifluoroacetic anhydride; C030242:phosphoric acid