title: Perspectives on tuberculosis pathogenesis and discovery of anti- tubercular drugs.
abstract: Based on the global burden of tuberculosis and resistant strains that have recently emerged, not responding to existing therapies, it has become urgent to search for new remedies against this global human plague that has been compounded by HIV co-infection. Thus, the search for new drugs against the disease-causing agent, Mycobacterium tuberculosis (MTB), is an ongoing effort. This review discusses the state-of-the-art in anti-tuberculosis pathogenesis and anti-TB drug research, identifying some of the challenges being faced by researchers in the field and sheds light on possible ways forward, particularly in low-income countries.
authors.forename: Fidele
authors.initials: F
authors.lastname: Ntie-Kang
authors.forename: Joseph N
authors.initials: JN
authors.lastname: Yong
authors.forename: Luc C
authors.initials: LC
authors.lastname: Owono Owono
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Sippl
authors.affiliation: CEPAMOQ, Faculty of Science, University of Douala, P.O. Box 8580, Douala, Cameroon. ntiekfidele@gmail.com.
authors.forename: Eugene
authors.initials: E
authors.lastname: Megnassan
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D015195:Drug Design; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D004359:Drug Therapy, Combination; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D014376:Tuberculosis / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology
chemical_list: D000995:Antitubercular Agents; D001688:Biological Products