title: Colorectal carcinoma in first decade of life: our experience.
abstract: BACKGROUND
  Though the lifetime risk of colorectal carcinoma (CRC) in general population is 5-6 %, it is uncommon in pediatric age group. Here, we are reporting our experience of CRC in the first decade of life.
  
  
  METHODS
  From January 2010 to December 2013, seven patients with histopathologically confirmed colorectal carcinoma were treated in the Department of Pediatric Surgery, Chittagong Medical College and hospital. Age, sex, presenting symptoms, location of the primary tumor, serum CEA level, treatment modalities and outcomes were evaluated.
  
  
  RESULTS
  There were four male and three female patients and age ranged from 6.5 to 10.5 years. Rectum (3 patients) and rectosigmoid (2 patients) were the most common primary sites. Serum carcinoembryonic antigen level was obtained in six patients and in only one patient the level was raised markedly (137 ng/ml). Two patients of familial adenomatous polyposis had localized disease and others presented in an advanced stage. Histopathologically, poorly differentiated adenocarcinoma was noted in five patients with one signet ring cell type and well differentiated in rest of the two patients. Only one patient was surviving at the last follow up.
  
  
  CONCLUSIONS
  Advanced stage at diagnosis, aggressive histologic subtype and poor survival are the hallmarks of pediatric CRC.
authors.affiliation: Department of Pediatric Surgery, Chittagong Medical College and Hospital, Chittagong, Bangladesh.
authors.forename: M A Mushfiqur
authors.initials: MA
authors.lastname: Rahman
authors.forename: Tanvir K
authors.initials: TK
authors.lastname: Chowdhury
authors.forename: Md Akbar Husain
authors.initials: MA
authors.lastname: Bhuiyan
authors.forename: Md Abdullah
authors.initials: MA
authors.lastname: Al Farooq
authors.forename: Md Minhajuddin
authors.initials: MM
authors.lastname: Sajid
authors.forename: Tahmina
authors.initials: T
authors.lastname: Banu
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000453:epidemiology* / Q000601:surgery; D000293:Adolescent; D001459:Bangladesh / Q000453:epidemiology; D014408:Biomarkers, Tumor / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000097:blood*; D002648:Child; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D011379:Prognosis; D012007:Rectum / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen