title: Comparison of gadobenate dimeglumine and gadopentetate dimeglumine for Breast MRI Screening: a meta-analysis.
abstract: BACKGROUND
  As a common and essential contrast medium at present, gadobenate dimeglumine has shown better performance than some other agents when applied to Breast Magnetic Resonance Imaging Screening (Breast MRI Screening). Nevertheless, reports on the diagnostic performance of these two mediums (gadobenate dimeglumine and gadopentetate dimeglumine) are not completely consistent.
  
  
  OBJECTIVE
  To assess the diagnostic value of gadobenate dimeglumine and gadopentetate dimeglumine for Breast MRI Screening in patients suffering from breast cancer and to provide more convinced evidence to guide clinical practice in terms of appropriate contrast agents.
  
  
  METHODS
  Original articles in English and Chinese published before January 2013 were selected from available databases (The Cochrane Library, PUBMED, EMBASE, Chinese Biomedical Literature Database, Chinese Scientific Journals Full-text Database, Chinese Journal Full-text). The criteria for inclusion and exclusion were based on the standard for diagnosis tests. Meta-Disc software (Version 1.4) was used for data analysis. Then, the area under curve (AUC) of SROC and the spearman rank correlation of sensitivity against (1-specificity) were calculated.
  
  
  RESULTS
  Total of 17 researches involving 1934 patients were included. The pooled sensitivity of gadobenate dimeglumine and gadopentetate dimeglumine were 0.99 (0.97, 1.00) and 0.93 (0.88, 1.00) respectively. The pooled specificity for these two contrast agents were 0.924 (0.902, 0.943) and 0.838 (0.817, 0.858) respectively, and the AUC of SROC curve were 0.9781 and 0.9215 respectively.
  
  
  CONCLUSIONS
  Gadobenate dimeglumine can be regarded as a more effective and feasible contrast medium for Breast MRI Screening. At least 5% differences in diagnostic performance are usually considered as clinically relevant.
authors.affiliation: Department of Radiology, the First Hospital of Medical College of Xi'an Jiaotong University, Xi'an, China E-mail : yangxiaoppinglz@163.com.
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Yang
authors.forename: Yue-Dong
authors.initials: YD
authors.lastname: Han
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Ye
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.forename: Ying
authors.initials: Y
authors.lastname: Luo
authors.forename: Hong-Xia
authors.initials: HX
authors.lastname: Ma
authors.forename: Xue-Wen
authors.initials: XW
authors.lastname: Yu
authors.forename: Juan-Qin
authors.initials: JQ
authors.lastname: Niu
authors.forename: Fang-Yuan
authors.initials: FY
authors.lastname: Ren
authors.forename: You-Ming
authors.initials: YM
authors.lastname: Guo
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis*; D003287:Contrast Media; D055088:Early Detection of Cancer; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008536:Meglumine / Q000031:analogs & derivatives*; D009942:Organometallic Compounds; D011379:Prognosis
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C064572:gadobenic acid; D008536:Meglumine; D019786:Gadolinium DTPA