title: Nonattenuated Polymyxin B Used for the Treatment of Extreme-Drug Resistant Acinetobacter baumannii-Related Infections in Patients with Preexisting End Stage Renal Failure.
abstract: Recent pharmacokinetic studies have suggested that nonrenal clearance predominates the elimination of polymyxin B. We present 2 patients with preexisting end stage renal failure, who were given nonattenuated doses of polymyxin B for the treatment of extreme-drug resistant organism. No evidence of adverse events occurred and microbiological clearance was documented.
authors.affiliation: Department of Pharmacy, Singapore General Hospital, Outram Road, Singapore 169608.
authors.forename: Yvonne Peijun
authors.initials: YP
authors.lastname: Zhou
authors.affiliation: Department of Pharmacy, Singapore General Hospital, Outram Road, Singapore 169608.
authors.forename: Nathalie Grace Sy
authors.initials: NG
authors.lastname: Chua
authors.affiliation: Department of Infectious Diseases, Singapore General Hospital, Outram Road, Singapore 169608.
authors.forename: Maciej Piotr
authors.identifier: 0000-0003-3003-5514
authors.initials: MP
authors.lastname: Chlebicki
authors.affiliation: Department of Pharmacy, Singapore General Hospital, Outram Road, Singapore 169608.
authors.forename: Winnie Hui Ling
authors.initials: WH
authors.lastname: Lee
authors.affiliation: Department of Pharmacy, Singapore General Hospital, Outram Road, Singapore 169608 ; Duke-NUS Emerging Infectious Diseases, 8 College Road, Singapore 169857.
authors.forename: Andrea Lay Hoon
authors.initials: AL
authors.lastname: Kwa