title: Effect on HPV vaccination in Japan resulting from news report of adverse events and suspension of governmental recommendation for HPV vaccination.
abstract: BACKGROUND
  Administration of the human papillomavirus (HPV) vaccine decreased dramatically in Japan after extensive news of adverse vaccine events and suspension of the governmental recommendation for the vaccine. In this study, we investigated the knowledge and acceptance of vaccinated adolescents concerning cervical cancer, cancer screening and the HPV vaccine. Furthermore, we analyzed whether and by how much the news affected acceptance of the vaccination.
  
  
  METHODS
  This study was conducted as a part of Osaka Clinical resEArch of HPV vacciNe (OCEAN) study. A questionnaire was distributed to 2,777 study registrants.
  
  
  RESULTS
  The response rate was 38%. The recognition rate of the news of the vaccine's adverse events was 80%; it was 68% for awareness of the government's announcement of the suspension of its recommendation for the vaccine. Among those who had a chance to hear or see the negative news during their vaccination period, 46 (60%) continued vaccination while knowing of the news, 22 (29%) discontinued vaccination, and 9 (11%) continued vaccination without an awareness of the news. Reports of the vaccine's adverse events were the main reason for not continuing the vaccination series. Those who consulted doctors after hearing the adverse news were significantly more likely to continue their vaccinations than those who did not.
  
  
  CONCLUSIONS
  Our results should help in understanding the need for a strong promotion of vaccine usage and cancer screening after future retraction of the recommendation suspension. This may apply to other countries with an unsatisfactory rate of HPV vaccination due to fears of adverse vaccine events.
authors.affiliation: The Obstetrical Gynecological Society of Osaka, 4-4-3 Kawaramachi, Chuo-ku, Osaka, 541-0048, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Morimoto
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Ueda
authors.forename: Tomomi
authors.initials: T
authors.lastname: Egawa-Takata
authors.forename: Asami
authors.initials: A
authors.lastname: Yagi
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Terai
authors.forename: Masahide
authors.initials: M
authors.lastname: Ohmichi
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Ichimura
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Sumi
authors.forename: Hiromi
authors.initials: H
authors.lastname: Murata
authors.forename: Hideharu
authors.initials: H
authors.lastname: Kanzaki
authors.forename: Hidekatsu
authors.initials: H
authors.lastname: Nakai
authors.forename: Masaki
authors.initials: M
authors.lastname: Mandai
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Yoshino
authors.forename: Masami
authors.initials: M
authors.lastname: Fujita
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kimura
authors.forename: Junko
authors.initials: J
authors.lastname: Saito
authors.forename: Tomotaka
authors.initials: T
authors.lastname: Sobue
authors.forename: Nobumichi
authors.initials: N
authors.lastname: Nishikawa
authors.forename: Masayuki
authors.initials: M
authors.lastname: Sekine
authors.forename: Takayuki
authors.initials: T
authors.lastname: Enomoto
authors.forename: Yorihiko
authors.initials: Y
authors.lastname: Horikoshi
authors.forename: Tetsu
authors.initials: T
authors.lastname: Takagi
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006287:Health Planning Guidelines; D006801:Humans; D007564:Japan; D008402:Mass Media; D030361:Papillomavirus Infections / Q000150:complications / Q000517:prevention & control*; D053918:Papillomavirus Vaccines / Q000009:adverse effects* / Q000627:therapeutic use; D010342:Patient Acceptance of Health Care; D011795:Surveys and Questionnaires; D002583:Uterine Cervical Neoplasms / Q000209:etiology / Q000517:prevention & control*; D014611:Vaccination / Q000706:statistics & numerical data*; D055815:Young Adult
chemical_list: D053918:Papillomavirus Vaccines