title: CD34+ eosinophil-lineage-committed cells in the mouse lung.
abstract: Several studies suggest that eosinophil progenitor cells are capable of extramedullary proliferation but also enhance chronic inflammation via their own production of inflammatory and chemotactic mediators, thus augmenting the degree of inflammation by recruitment of more progenitors or mature effector cells, such as eosinophils at the site of inflammation. In this chapter, we provide methods focused on detecting eosinophil progenitor cells in the lung of allergen-challenged mice and how to monitor their proliferation capacity.
authors.affiliation: Krefting Research Centre, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
authors.forename: Apostolos
authors.initials: A
authors.lastname: Bossios
authors.forename: Madeleine
authors.initials: M
authors.lastname: Rådinger
mesh_terms: D000818:Animals; D018952:Antigens, CD34 / Q000378:metabolism*; D049109:Cell Proliferation / Q000502:physiology; D004804:Eosinophils / Q000166:cytology* / Q000378:metabolism*; D008168:Lung / Q000166:cytology*; D051379:Mice; D013234:Stem Cells / Q000166:cytology*
chemical_list: D018952:Antigens, CD34