title: Partial extracorporeal carbon dioxide removal using a standard continuous renal replacement therapy device: a preliminary study.
abstract: To test the feasibility, safety, and efficacy of partial extracorporeal CO2 removal (PECCO2R) using a standard continuous renal replacement (CRRT) device with a pediatric oxygenation membrane introduced into the circuit in a serial manner. In this retrospective single-center study, we have studied mechanically ventilated patients with persistent significant respiratory acidosis and acute renal failure requiring ongoing CRRT. Sixteen patients were treated with our PECCO2R device. PaCO2 and arterial pH were measured before as well as at 6 and 12 hours after PECCO2R implementation. Hemodynamic parameters were continuously monitored. Our PECCO2R system was efficient to significantly reduce PaCO2 and increase arterial pH. The median PaCO2 before treatment was 77 mm Hg (59-112) with a median reduction of 24 mm Hg after 6 hours and 30 mm Hg after 12 hours (31% and 39%, respectively). The median pH increase was 0.16 at 6 hours and 0.23 at 12 hours. Partial extracorporeal CO2 removal treatment had no effect on oxygenation. No complication was observed. Our PECCO2R approach based on the simple introduction of a pediatric extracorporeal membrane oxygenation membrane into the circuit of a standard CRRT device is easy to implement, safe, and efficient to improve respiratory acidosis.
authors.affiliation: From the Medical and Surgical Intensive Care Unit, Centre Hospitalier de Perpignan, Perpignan, France.
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Quintard
authors.forename: Olivier
authors.initials: O
authors.lastname: Barbot
authors.forename: Florence
authors.initials: F
authors.lastname: Thevenot
authors.forename: Olivier
authors.initials: O
authors.lastname: de Matteis
authors.forename: Laurent
authors.initials: L
authors.lastname: Benayoun
authors.forename: Frank
authors.initials: F
authors.lastname: Leibinger
mesh_terms: D058186:Acute Kidney Injury / Q000628:therapy*; D000368:Aged; D002245:Carbon Dioxide / Q000378:metabolism; D015199:Extracorporeal Membrane Oxygenation / Q000295:instrumentation*; D005240:Feasibility Studies; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008171:Lung Diseases / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D017582:Renal Replacement Therapy / Q000295:instrumentation* / Q000379:methods; D012121:Respiration, Artificial; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D002245:Carbon Dioxide