title: Anticancer gene transfer for cancer gene therapy.
abstract: Gene therapy vectors are among the treatments currently used to treat malignant tumors. Gene therapy vectors use a specific therapeutic transgene that causes death in cancer cells. In early attempts at gene therapy, therapeutic transgenes were driven by non-specific vectors which induced toxicity to normal cells in addition to the cancer cells. Recently, novel cancer specific viral vectors have been developed that target cancer cells leaving normal cells unharmed. Here we review such cancer specific gene therapy systems currently used in the treatment of cancer and discuss the major challenges and future directions in this field.
authors.affiliation: University of California-San Francisco (UCSF), 600 16th st, Genentech Hall, San Francisco, CA, 94158, USA.
authors.forename: Evangelos
authors.initials: E
authors.lastname: Pazarentzos
authors.forename: Nicholas D
authors.initials: ND
authors.lastname: Mazarakis
mesh_terms: D000818:Animals; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000628:therapy*; D050130:Oncolytic Virotherapy / Q000379:methods*; D050504:Oncolytic Viruses; D019076:Transgenes