title: Can the three pore model correctly describe peritoneal transport of protein?
abstract: The three pore model (3PM) includes large pores for the description of protein leak to the peritoneal cavity during peritoneal dialysis. However, the reliability of this description has been not fully tested against clinical data yet. Peritoneal transport parameters were estimated using 3PM, extended 3p model (with estimation of fraction of large pores, ext3PM), ext3PM with modified size of pores and proteins (mext3PM), and simplified two pore (2PM, small and ultrasmall pores) models for 32 patients on peritoneal dialysis investigated using the sequential peritoneal equilibration test (consecutive peritoneal equilibration test [PET]: glucose 2.27%, 4 h, and miniPET: glucose 3.86%, 1 h). Urea, creatinine, glucose, sodium, phosphate, albumin, and IgM concentrations were measured in dialysis fluid and plasma. Ext3PM and mext3PM, with large pore fraction of about 0.14, provided a good description of fluid and small solute kinetics, but their predictions for albumin transport were less accurate. Two pore model precisely described the data on fluid and small solute transport. The 3p models could not describe the diffusive-convective transport of albumin as precisely as the transport of fluid, small solutes, and IgM. The 2p model (not applicable for proteins) was an efficient tool for modeling fluid and small solute transport.
authors.affiliation: From the *Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland; and †Military Institute of Medicine, Warsaw, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Waniewski
authors.forename: Jan
authors.initials: J
authors.lastname: Poleszczuk
authors.forename: Stefan
authors.initials: S
authors.lastname: Antosiewicz
authors.forename: Daniel
authors.initials: D
authors.lastname: Baczynński
authors.forename: Magda
authors.initials: M
authors.lastname: Gałach
authors.forename: Mauro
authors.initials: M
authors.lastname: Pietribiasi
authors.forename: Zofia
authors.initials: Z
authors.lastname: Wanńkowicz
mesh_terms: D001692:Biological Transport / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D010530:Peritoneal Dialysis