title: Pd(II)-catalyzed meta-C-H olefination, arylation, and acetoxylation of indolines using a U-shaped template.
abstract: meta-C-H olefination, arylation, and acetoxylation of indolines have been developed using nitrile-containing templates. The combination of a monoprotected amino acid ligand and the nitrile template attached at the indolinyl nitrogen via a sulfonamide linkage is crucial for the meta-selective C-H functionalization of electron-rich indolines that are otherwise highly reactive toward electrophilic palladation at the para-positions. A wide range of synthetically important and advanced indoline analogues are selectively functionalized at the meta-positions.
authors.affiliation: Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Yang
authors.forename: Petra
authors.initials: P
authors.lastname: Lindovska
authors.forename: Dajian
authors.initials: D
authors.lastname: Zhu
authors.forename: Justin
authors.initials: J
authors.lastname: Kim
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.forename: Ri-Yuan
authors.initials: RY
authors.lastname: Tang
authors.forename: Mohammad
authors.initials: M
authors.lastname: Movassaghi
authors.forename: Jin-Quan
authors.initials: JQ
authors.lastname: Yu