title: Severe fever with thrombocytopenia syndrome in children: a case report.
abstract: BACKGROUND
  Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel bunyavirus (SFTSV) in China. Humans of all ages living in endemic areas have high risk of acquiring SFTS. Most clinical data so far have been from adults and no clinical study was available from children yet. The present study identified four SFTSV infected children through hospital based surveillance. A prospective observational study was performed to obtain their clinical and laboratory characteristics.
  
  
  METHODS
  The patients' age ranged from 4-15 years old and two were male. On hospitalization, fever, malaise and gastrointestinal syndromes were the most commonly presenting symptoms. Hemorrhagic symptoms or neurological manifestation was not recorded in any of the four pediatric patients. Hematological abnormalities at admission into hospital included leucopenia (4 cases), thrombocytopenia (1 case) and bicytopenia (1 case). The abnormal parameters included elevated aminotransferase (1 case), alanine transaminase (2 case), and lactate dehydrogenase (3 case). Laboratory parameters indicative of renal damage was not observed during the hospitalization. All the patients recovered well without sequelae being observed.
  
  
  CONCLUSIONS
  Compared with adults, pediatric patients with SFTSV infection seem to have less vague subjective complaints and less aggressive clinical course. Thrombocytopenia is suggested to be used less rigorously in recognizing SFTSV infection in pediatric patients, especially at early phase of disease.
authors.forename: Li-Yuan
authors.initials: LY
authors.lastname: Wang
authors.forename: Ning
authors.initials: N
authors.lastname: Cui
authors.forename: Qing-Bin
authors.initials: QB
authors.lastname: Lu
authors.forename: Ying
authors.initials: Y
authors.lastname: Wo
authors.forename: Hong-Yu
authors.initials: HY
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, P, R, China. lwbime@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Wu-Chun
authors.initials: WC
authors.lastname: Cao
mesh_terms: D000293:Adolescent; D002648:Child; D002673:Child, Hospitalized / Q000706:statistics & numerical data*; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D005260:Female; D005334:Fever / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D008297:Male; D011446:Prospective Studies; D018571:Sentinel Surveillance; D013577:Syndrome; D013921:Thrombocytopenia / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control