title: Cronkhite-Canada syndrome associated with esophageal and gastric cancers: report of a case.
abstract: Cronkhite-Canada Syndrome (CCS) is a rare non-inherited gastrointestinal polyposis syndrome with characteristic ectodermal changes. We report an extremely unusual case of CCS associated with primary esophageal and gastric cancers. A 74-year-old Japanese man with symptoms of anorexia and diarrhea was found to have primary esophageal and gastric cancers, as well as multiple gastric and colonic polyps. Based on the physical findings of onychodystrophy and alopecia, we diagnosed CCS. Because of his age and nutritional status, we decided to perform total gastrectomy for gastric cancer and chemoradiotherapy for esophageal cancer, upon completion of which the patient was started on steroid therapy for the CCS. After 1 week of steroid therapy, the patient's watery diarrhea improved. We recommend that for patients with CCS, the therapeutic strategy be carefully considered based on the patient's nutritional status, the severity of the CCS, and the extent of gastrointestinal cancer.
authors.affiliation: Department of Surgery, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan, mito@naramed-u.ac.jp.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ito
authors.forename: Sohei
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Tomoyoshi
authors.initials: T
authors.lastname: Takayama
authors.forename: Kohei
authors.initials: K
authors.lastname: Wakatsuki
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tanaka
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Migita
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Nakajima
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000473:pathology / Q000601:surgery*; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000473:pathology / Q000628:therapy*; D059248:Chemoradiotherapy; D016099:Endoscopy, Gastrointestinal; D004938:Esophageal Neoplasms / Q000150:complications* / Q000473:pathology / Q000628:therapy*; D005743:Gastrectomy; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D044483:Intestinal Polyposis / Q000150:complications* / Q000188:drug therapy*; D008297:Male; D009378:Neoplasms, Multiple Primary; D009752:Nutritional Status; D011239:Prednisolone / Q000008:administration & dosage; D012720:Severity of Illness Index; D013274:Stomach Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery*
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone