title: SPSB1 may have MET its match during breast cancer recurrence.
abstract: Disease recurrence is the most common cause of death for patients with breast cancer, yet little is known about the molecular mechanisms underlying this process. Using inducible transgenic mouse model systems, Feng and colleagues identified SPSB1 as a determinant of breast cancer recurrence by virtue of its ability to protect tumor cells from apoptosis through c-MET activation.
authors.affiliation: Authors' Affiliations:Hematology Division, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School;
authors.forename: Yuanbo
authors.initials: Y
authors.lastname: Qin
authors.affiliation: Authors' Affiliations:Hematology Division, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School; Harvard Stem Cell Institute, Boston; and Broad Institute of Harvard and MIT, Cambridge, Massachusetts smcallister1@partners.org.
authors.forename: Sandra S
authors.initials: SS
authors.lastname: McAllister
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000235:genetics*; D019859:Proto-Oncogene Proteins c-met / Q000378:metabolism*; D050826:Suppressor of Cytokine Signaling Proteins / Q000235:genetics*
chemical_list: D050826:Suppressor of Cytokine Signaling Proteins; D019859:Proto-Oncogene Proteins c-met