title: Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer.
abstract: Colorectal cancer is the third most common cancer worldwide. Survival and prognosis depend on tumor stage upon diagnosis, and in more than 50% of cases, the tumor has already invaded adjacent tissues or metastasis has occurred. Aiming to improve diagnosis, clinical prognosis and treatment of patients with colorectal cancer, several studies have investigated microRNAs as molecular markers of the disease due to their potential regulatory functions on tumor suppressor genes and oncogenes. This review aimed to summarize the main topics related to the use of microRNAs in diagnosis, clinical prognosis and evaluating treatment response in colorectal cancer.
authors.affiliation: Universidade Católica de Brasília, Brasilia, DF, Brazil.
authors.forename: Silmara Cristiane da Silveira
authors.initials: SC
authors.lastname: Andreoli
authors.affiliation: Universidade Católica de Brasília, Brasilia, DF, Brazil.
authors.forename: Nina Jardim
authors.initials: NJ
authors.lastname: Gasparini
authors.affiliation: Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Gisele Pereira
authors.initials: GP
authors.lastname: de Carvalho
authors.affiliation: Centro de Oncologia Sírio Libanês, São Paulo, SP, Brazil.
authors.forename: Bernardo
authors.initials: B
authors.lastname: Garicochea
authors.affiliation: Universidade Católica de Brasília, Brasilia, DF, Brazil.
authors.forename: Robert Edward
authors.initials: RE
authors.lastname: Pogue
authors.affiliation: Universidade Católica de Brasília, Brasilia, DF, Brazil.
authors.forename: Rosângela Vieira
authors.initials: RV
authors.lastname: de Andrade
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D000069287:Capecitabine; D059186:Chemoradiotherapy, Adjuvant; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D003841:Deoxycytidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D005472:Fluorouracil / Q000031:analogs & derivatives / Q000627:therapeutic use; D015972:Gene Expression Regulation, Neoplastic; D005819:Genetic Markers; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D009361:Neoplasm Invasiveness / Q000235:genetics; D009367:Neoplasm Staging; D009944:Organoplatinum Compounds / Q000627:therapeutic use; D000077150:Oxaliplatin; D011379:Prognosis; D000077185:Resveratrol; D013267:Stilbenes / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D005819:Genetic Markers; D035683:MicroRNAs; D009944:Organoplatinum Compounds; D013267:Stilbenes; D000077150:Oxaliplatin; D003841:Deoxycytidine; D000069287:Capecitabine; D000077185:Resveratrol; D005472:Fluorouracil