title: Oral manifestations of hereditary nonpolyposis colorectal cancer syndrome: a family case series.
abstract: BACKGROUND
  Hereditary nonpolyposis colorectal cancer is a colorectal cancer syndrome characterized by the development of colorectal cancer and extracolonic tumors, and this syndrome has an autosomal dominant mode of inheritance. To our knowledge, our study was the first to find dento-osseous anomalies and the second to observe Fordyce granules in a family with individuals with hereditary nonpolyposis colorectal cancer.
  
  
  METHODS
  Twenty members of one Brazilian family with individuals with hereditary nonpolyposis colorectal cancer were analyzed according to the presence of colorectal cancer and the occurrence of Fordyce granules and dento-osseous anomalies. Their average age was 29.6 (range 7 to 53 years) years. Medical examinations of this family with hereditary nonpolyposis colorectal cancer were performed at the Coloproctology Division of our hospital. Then, all individuals were referred to our Oral Care Center for Inherited Diseases for intraoral examinations to verify the presence of Fordyce granules. Dental panoramic radiographs were done in order to describe dento-osseous anomalies on applying the Dental Panoramic Radiograph System. Of the 20 family members, four were diagnosed with hereditary nonpolyposis colorectal cancer and all four presented Fordyce granules in their upper lip, but only one of these four patients (Case 2) had a significant dento-osseous anomaly.
  
  
  CONCLUSIONS
  Our familial study verified the presence of Fordyce granules in all individuals diagnosed with hereditary nonpolyposis colorectal cancer, and the presence of significant dento-osseous anomalies in one of these cases. However, the relationship between oral manifestations and hereditary nonpolyposis colorectal cancer should be further investigated.
authors.forename: Fabiana Tolentino
authors.initials: FT
authors.lastname: Almeida
authors.forename: Raquel Ribeiro
authors.initials: RR
authors.lastname: Gomes
authors.forename: André Ferreira
authors.initials: AF
authors.lastname: Leite
authors.forename: João Batista
authors.initials: JB
authors.lastname: Sousa
authors.forename: Ana Carolina
authors.initials: AC
authors.lastname: Acevedo
authors.affiliation: Oral Care Center for Inherited Diseases, Division of Dentistry at University Hospital of Brasilia, Faculty of Health Sciences, University of Brasilia (UNB), Brasilia, Brazil. elieteneves@unb.br.
authors.forename: Eliete Neves Silva
authors.initials: EN
authors.lastname: Guerra
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000150:complications / Q000235:genetics / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009056:Mouth Abnormalities / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D010375:Pedigree; D012627:Sebaceous Glands / Q000473:pathology; D013577:Syndrome; D055815:Young Adult