title: Carbazole alkaloids from the peels of Clausena lansium.
abstract: A new carbazole alkaloid, claulansine K (1), together with six known carbazole alkaloids (2-7), was isolated from the peels of Clausena lansium (Lour.) Skeels. The new compound was elucidated using a combination of 1D and 2D NMR (HMQC, HMBC, COSY, and ROESY) techniques, and HR-EI-MS analyses. Compound 1 showed in vitro α-glucosidase inhibitory activity with the IC50 value of 0.11 mM. Compound 2 exhibited moderate antibacterial activity against Staphylococcus aureus with the diameter of inhibition zone of 14.2 mm.
authors.affiliation: a Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences , Haikou 571101 , China.
authors.forename: Hui-Dong
authors.initials: HD
authors.lastname: Deng
authors.forename: Wen-Li
authors.initials: WL
authors.lastname: Mei
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Zhi-Kai
authors.initials: ZK
authors.lastname: Guo
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Dong
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.forename: Shao-Peng
authors.initials: SP
authors.lastname: Li
authors.forename: Hao-Fu
authors.initials: HF
authors.lastname: Dai
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002227:Carbazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D054700:Clausena / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018547:Plant Stems / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects*
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D002227:Carbazoles; D004365:Drugs, Chinese Herbal; D065089:Glycoside Hydrolase Inhibitors; C000593059:claulansine K
keywords: Clausena lansium; Rutaceae; antibacterial activity; carbazole alkaloids; α-glucosidase inhibitory activity