title: Transient adult microbiota, gut homeostasis and longevity: novel insights from the Drosophila model.
abstract: In the last decade, Drosophila has emerged as a useful model to study host-microbiota interactions, creating an active research field with prolific publications. In the last 2 years, several studies contributed to a better understanding of the dynamic nature of microbiota composition and its impact on gut immunity and intestinal tissue homeostasis. These studies depicted the mechanisms by which microbiota regulates gut homeostasis to modulate host fitness and lifespan. Moreover, the latest findings demonstrating that the gut is a physiologically and histologically compartmentalized organ brought fresh perspectives to study the region-specific nature of the interactions between the commensal microbes and the intestinal tissue, and consequences of these interactions on overall host biology.
authors.affiliation: Institut de Génomique Fonctionnelle de Lyon (IGFL), Ecole Normale Supérieure de Lyon, CNRS, Université Claude Bernard Lyon-1, UMR 5242, F-69364 Lyon, France.
authors.forename: Berra
authors.initials: B
authors.lastname: Erkosar
authors.affiliation: Institut de Génomique Fonctionnelle de Lyon (IGFL), Ecole Normale Supérieure de Lyon, CNRS, Université Claude Bernard Lyon-1, UMR 5242, F-69364 Lyon, France. Electronic address: francois.leulier@ens-lyon.fr.
authors.forename: François
authors.initials: F
authors.lastname: Leulier
mesh_terms: D000818:Animals; D004330:Drosophila / Q000276:immunology / Q000382:microbiology* / Q000502:physiology*; D041981:Gastrointestinal Tract / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology* / Q000502:physiology; D006706:Homeostasis; D008136:Longevity; D064307:Microbiota; D012038:Regeneration
keywords: Drosophila; Gut; Gut immunity; Intestinal stem cells; Longevity; Microbiota