title: Lumazine peptides penilumamides B-D and the cyclic pentapeptide asperpeptide A from a gorgonian-derived Aspergillus sp. fungus.
abstract: Three new lumazine peptides, penilumamides B-D (2-4), and one known analogue, penilumamide (1), together with a new cyclic pentapeptide, asperpeptide A (5), were isolated from the gorgonian-derived fungus Aspergillus sp. XS-20090B15. Among them, 2 was obtained from the feeding culture with l-methionine of this strain. All structures were elucidated by spectroscopic methods and chemical derivatization. Compounds 1-4 are rare lumazine peptides, of which 1 and 3 are formed from 2 by oxidation of the l-methionine residue.
authors.affiliation: Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.forename: Chang-Lun
authors.initials: CL
authors.lastname: Shao
authors.forename: Xiu-Mei
authors.initials: XM
authors.lastname: Fu
authors.forename: Chui-Jian
authors.initials: CJ
authors.lastname: Kong
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: She
authors.forename: Chang-Yun
authors.initials: CY
authors.lastname: Wang
mesh_terms: D000470:Alkaloids / Q000494:pharmacology; D000818:Animals; D037421:Anthozoa / Q000382:microbiology*; D001230:Aspergillus / Q000737:chemistry*; D001409:Bacillus cereus / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D008715:Methionine / Q000031:analogs & derivatives / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009615:Nocardia / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D009842:Oligopeptides / Q000737:chemistry; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification*; D011549:Pseudomonas / Q000187:drug effects; D011621:Pteridines / Q000737:chemistry; D019779:Salmonella enterica / Q000187:drug effects; D012717:Sesquiterpenes / Q000494:pharmacology; D013210:Staphylococcus / Q000187:drug effects; D014733:Vibrio / Q000187:drug effects
chemical_list: D000470:Alkaloids; D009842:Oligopeptides; D010456:Peptides, Cyclic; D011621:Pteridines; D012717:Sesquiterpenes; C000591561:asperpeptide A; C550764:penilumamide; C000591558:penilumamide B; C000591560:penilumamide C; C000591559:penilumamide D; C050426:huperzine A; C008297:lumazine; D008715:Methionine