title: Generation of thyroid follicular cells from pluripotent stem cells: potential for regenerative medicine.
abstract: Nearly 12% of the population in the United States will be afflicted with a thyroid related disorder during their lifetime. Common treatment approaches are tailored to the specific disorder and include surgery, radioactive iodine ablation, antithyroid drugs, thyroid hormone replacement, external beam radiation, and chemotherapy. Regenerative medicine endeavors to combat disease by replacing or regenerating damaged, diseased, or dysfunctional body parts. A series of achievements in pluripotent stem cell research have transformed regenerative medicine in many ways by demonstrating "repair" of a number of body parts in mice, of which, the thyroid has now been inducted into this special group. Seminal work in pluripotent cells, namely embryonic stem cells and induced pluripotent stem cells, have made possible their path to becoming key tools and biological building blocks for cell-based regenerative medicine to combat the gamut of human diseases, including those affecting the thyroid.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Saint Louis University School of Medicine , St. Louis, MO , USA.
authors.forename: Will
authors.initials: W
authors.lastname: Sewell
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Saint Louis University School of Medicine , St. Louis, MO , USA.
authors.forename: Reigh-Yi
authors.initials: RY
authors.lastname: Lin
keywords: cell replacement therapy; embryonic stem cells; induced pluripotent stem cells; pluripotent stem cells; regenerative medicine; stem cells; thyroid; thyroid follicular cells