title: Relation of mean platelet volume with obstructive adenoid hypertrophy in children.
abstract: OBJECTIVE
  Adenoid hypertrophy (AH) is a common etiology of chronic upper airway obstruction. Upper respiratory tract obstruction may cause chronic alveolar hypoventilation and pulmonary vasoconstriction. In one previous study in patients with obstructive sleep apnea (OSA), it has been claimed that mean platelet volume (MPV), an indicator of platelet activation is increased and that MPV has an important role in the pathophysiology of cardiovascular diseases. We investigated in our study if MPV can be used as an indicator of obstruction due to adenoid hypertrophy.
  
  
  METHODS
  Our study includes 61 children that underwent adenoidectomy with a mean age of 7.12 (± 2.373). White blood cell, platelet count, MPV, platelet crit and platelet distribution width levels were measured before and 3 months after adenoidectomy. Children's symptoms for upper airway obstruction (UAO) (presence of snoring, mouth breathing or difficulty in breathing during sleep, obstructive breathing or apnea during sleep) were questioned in the preoperative and postoperative period by a standardized questionnaire.
  
  
  RESULTS
  There was no significant difference between preoperative and postoperative mean values of MPV, hemoglobin, platelet count (p > 0.05). White blood cell levels were significantly higher in the preoperative period values compared with postoperative period values (p < 0.05). Preoperative UAO scores were significantly higher than the postoperative UAO scores. After stratification of the degree of obstruction (as mild, moderate and severe) there was no significant difference in between groups in terms of MPV values.
  
  
  CONCLUSIONS
  There was no significant relation between MPV levels and obstructive adenoid hypertrophy.
authors.affiliation: Umraniye Research and Education Hospital, Department of Otolaryngology, Istanbul, Turkey. Electronic address: serap_sahin1985@hotmail.com.
authors.forename: Serap
authors.initials: S
authors.lastname: Onder
authors.affiliation: Umraniye Research and Education Hospital, Department of Otolaryngology, Istanbul, Turkey.
authors.forename: Basak
authors.initials: B
authors.lastname: Caypinar
authors.affiliation: Umraniye Research and Education Hospital, Department of Otolaryngology, Istanbul, Turkey.
authors.forename: Asli
authors.initials: A
authors.lastname: Sahin-Yilmaz
authors.affiliation: Umraniye Research and Education Hospital, Department of Otolaryngology, Istanbul, Turkey.
authors.forename: Sema Zer
authors.initials: SZ
authors.lastname: Toros
authors.affiliation: Umraniye Research and Education Hospital, Department of Otolaryngology, Istanbul, Turkey.
authors.forename: Cagatay
authors.initials: C
authors.lastname: Oysu
mesh_terms: D000233:Adenoidectomy; D000234:Adenoids / Q000473:pathology*; D000402:Airway Obstruction / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D006801:Humans; D006984:Hypertrophy; D063847:Mean Platelet Volume / Q000379:methods*; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000175:diagnosis; D011795:Surveys and Questionnaires
keywords: Adenoid hypertrophy; Adenoidectomy; Mean platelet volume; Pediatric obstructive sleep apnea