title: Hypermetabolism during resting-state FDG-PET suggesting intrinsic epileptogenicity in focal cortical dysplasia.
abstract: We report the case of a 21-year-old man who presented drug-resistant epilepsy since the age of 3 years. The underlying type Ia left prefrontal focal cortical dysplasia was revealed by focal hypermetabolism of FDG-PET several years later. The stereo-electroencephalography showed continuous interictal rhythmic spike discharges, suggesting the dysplastic character of the cortex explored by depth electrodes placed into and at the margins of PET abnormalities. The surgical limits of resection were defined based on interictal activity, spontaneous and induced seizures. The patient is seizure-free, with normal electroencephalography and clear improvement of neuropsychological performance, without functional deficit at 3 years postsurgery.
authors.affiliation: From the *Service de Biophysique et Médecine Nucléaire, France; †ICube, Université de Strasbourg/CNRS, France; ‡Faculté de Médecine, Fédération de Médecine Translationnelle de Strasbourg, France; §Unité Médico-chirurgicale de l'Epilepsie, France; and ¶Service d'Anatomie Pathologique, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, France.
authors.forename: Izzie Jacques
authors.initials: IJ
authors.lastname: Namer
authors.forename: Maria Paola
authors.initials: MP
authors.lastname: Valenti-Hirsch
authors.forename: Julia
authors.initials: J
authors.lastname: Scholly
authors.forename: Béatrice
authors.initials: B
authors.lastname: Lannes
authors.forename: Alessio
authors.initials: A
authors.lastname: Imperiale
authors.forename: Edouard
authors.initials: E
authors.lastname: Hirsch
mesh_terms: D004569:Electroencephalography; D004827:Epilepsy / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging*; D019788:Fluorodeoxyglucose F18; D005625:Frontal Lobe / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D054220:Malformations of Cortical Development / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D055815:Young Adult
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18