title: Genome-wide analysis of HOXC9-induced neuronal differentiation of neuroblastoma cells.
abstract: Induction of differentiation is a therapeutic strategy in neuroblastoma, a common pediatric cancer of the sympathetic nervous system. The homeobox protein HOXC9 is a key regulator of neuroblastoma differentiation. To gain a molecular understanding of the function of HOXC9 in promoting differentiation of neuroblastoma cells, we conducted a genome-wide analysis of the HOXC9-induced differentiation program by microarray gene expression profiling and chromatin immunoprecipitation in combination with massively parallel sequencing (ChIP-seq). Here we describe in details the experimental system, methods, and quality control for the generation of the microarray and ChIP-seq data associated with our recent publication [1].
authors.forename: Xiangwei
authors.initials: X
authors.lastname: Wang
authors.forename: Liqun
authors.initials: L
authors.lastname: Yang
authors.forename: Jeong-Hyeon
authors.initials: JH
authors.lastname: Choi
authors.forename: Eiko
authors.initials: E
authors.lastname: Kitamura
authors.forename: Chang-Sheng
authors.initials: CS
authors.lastname: Chang
authors.forename: Jane
authors.initials: J
authors.lastname: Ding
authors.forename: Eun J
authors.initials: EJ
authors.lastname: Lee
authors.forename: Hongjuan
authors.initials: H
authors.lastname: Cui
authors.forename: Han-Fei
authors.initials: HF
authors.lastname: Ding