title: Synthesis of riboflavines, quinoxalinones and benzodiazepines through chemoselective flow based hydrogenations.
abstract: Robust chemical routes towards valuable bioactive entities such as riboflavines, quinoxalinones and benzodiazepines are described. These make use of modern flow hydrogenation protocols enabling the chemoselective reduction of nitro group containing building blocks in order to rapidly generate the desired amine intermediates in situ. In order to exploit the benefits of continuous processing the individual steps were transformed into a telescoped flow process delivering selected benzodiazepine products on scales of 50 mmol and 120 mmol respectively.
authors.affiliation: Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, UK.
authors.forename: Marcus
authors.initials: M
authors.lastname: Baumann
authors.affiliation: Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, UK. i.r.baxendale@durham.ac.uk.
authors.forename: Ian R
authors.initials: IR
authors.lastname: Baxendale
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
authors.forename: Christian H
authors.initials: CH
authors.lastname: Hornung
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
authors.forename: Maria Victoria
authors.initials: MV
authors.lastname: Rojo
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
authors.forename: Kimberley A
authors.initials: KA
authors.lastname: Roper
mesh_terms: D001569:Benzodiazepines / Q000138:chemical synthesis / Q000737:chemistry*; D006865:Hydrogenation; D012256:Riboflavin / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D001569:Benzodiazepines; D012256:Riboflavin