title: Association of glycemic status with impaired lung function among recipients of a health screening program: a cross-sectional study in Japanese adults.
abstract: BACKGROUND
  The dose-response relationship between glycemic status and lung function has not been thoroughly investigated. We hypothesized that there are continuous and inverse associations between glycemic measures and lung function tests and examined the hypothesis in Japanese adults.
  
  
  METHODS
  We cross-sectionally investigated associations of hemoglobin A1c (HbA1c) and fasting plasma glucose (FPG) with forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) in 3161 adults who participated in a health screening from 2008 to 2011. The study participants included both diabetic and non-diabetic adults. Multiple linear regression analyses were performed to examine the associations.
  
  
  RESULTS
  Inverse associations were observed in both sexes, which were attenuated in women after adjustment for multiple variables. A 1% absolute increase in HbA1c was associated with a -52-mL (95% confidence interval [CI] -111 to 8 mL) difference in FVC and a -25-mL (95% CI -75 to 25 mL) difference in FEV1 in women, and a -128-mL (95% CI -163 to -94 mL) difference in FVC and a -73-mL (95% CI -101 to -44 mL) difference in FEV1 in men. A 10-mg/dL increase in FPG was associated with a -11-mL (95% CI -29 to 8 mL) difference in FVC and a -8-mL (95% CI -24 to 7 mL) difference in FEV1 in women, and a -32-mL (95% CI -44 to -21 mL) difference in FVC and a -19-mL (95% CI -28 to -9 mL) difference in FEV1 in men.
  
  
  CONCLUSIONS
  Inverse associations between glycemic measures and lung function were observed. Men seem more susceptible to the alteration in FVC and FEV1 than women.
authors.affiliation: Department of Internal Medicine, Saiseikai Central Hospital.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kabeya
authors.forename: Kiyoe
authors.initials: K
authors.lastname: Kato
authors.forename: Masuomi
authors.initials: M
authors.lastname: Tomita
authors.forename: Takeshi
authors.initials: T
authors.lastname: Katsuki
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Oikawa
authors.forename: Akira
authors.initials: A
authors.lastname: Shimada
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis / Q000502:physiology*; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000097:blood / Q000503:physiopathology; D005215:Fasting / Q000097:blood / Q000502:physiology*; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology*; D006442:Glycated Hemoglobin / Q000032:analysis / Q000502:physiology*; D006801:Humans; D007564:Japan; D016014:Linear Models; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D014797:Vital Capacity / Q000502:physiology*
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin