title: Diastereoselective construction of tetrahydropyridine fused bicyclic structures via three-component domino reaction.
abstract: The three-component reactions of enals, electron-deficient alkynes, and hydroxyl-functionalized primary amines for the highly diastereoselective construction of dihydro-3H-benzo[4,5]oxazolo[3,2-a]pyridines, hexahydropyrido[2,1-b][1,3]oxazines, and tetrahydro-2H-oxazolo[3,2-a]pyridines have been achieved. Domino formation of one C-C, two C-N, and one C-O bonds are furnished in these reactions. This bis-annulation protocol allows for the synthesis of fused heterocyclic products of high structural diversity with variation not only of appended fragments but also the ring size of the central backbone.
authors.affiliation: College of Chemistry and Chemical Engineering, Jiangxi Normal University , Nanchang 330022, PR China.
authors.forename: Jie-Ping
authors.initials: JP
authors.lastname: Wan
authors.forename: Yunfang
authors.initials: Y
authors.lastname: Lin
authors.forename: Qing
authors.initials: Q
authors.lastname: Huang
authors.forename: Yunyun
authors.initials: Y
authors.lastname: Liu