title: In vitro analysis of pyrogenicity and cytotoxicity profiles of flex sensors to be used to sense human joint postures.
abstract: Flex sensors can be usefully adopted as mechanical-electrical transducers to measure human joint movements, since their electrical resistance varies proportionally to the angle assumed by the joint under measure. Over time, these sensors have been investigated in terms of mechanical and electrical behavior, but no reports have detailed the possibility of their adoption not just on top but under the human skin of the joint. To this aim, our work investigated in vitro the pyrogenic potential and cytotoxicity of some commercially available flex sensors as a first step toward the necessary requirements regarding their biocompatibility, to predict possible foreign body reactions when used in vivo. Results demonstrated that some specific flex sensors satisfy such requirements.
authors.affiliation: Department of Electronic Engineering, University of Tor Vergata, via del Politecnico, 1-00133 Rome, Italy. saggio@uniroma2.it.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Saggio
authors.affiliation: Department of Civil Engineering and Computer Science, University of Tor Vergata, via del Politecnico, 1-00133 Rome, Italy. luigi.bianchi@uniroma2.it.
authors.forename: Luigi
authors.initials: L
authors.lastname: Bianchi
authors.affiliation: Department of Biology, University of Tor Vergata, Via della Ricerca Scientifica, 1-00173 Rome, Italy. cstslv00@uniroma2.it.
authors.forename: Silvia
authors.initials: S
authors.lastname: Castelli
authors.affiliation: Department of Biology, University of Tor Vergata, Via della Ricerca Scientifica, 1-00173 Rome, Italy. santucci@scienze.uniroma2.it.
authors.forename: Marilina B
authors.initials: MB
authors.lastname: Santucci
authors.affiliation: Department of Biology, University of Tor Vergata, Via della Ricerca Scientifica, 1-00173 Rome, Italy. Fraziano@bio.uniroma2.it.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Fraziano
authors.affiliation: Department of Biology, University of Tor Vergata, Via della Ricerca Scientifica, 1-00173 Rome, Italy. desideri@uniroma2.it.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Desideri
mesh_terms: D053587:Arthrometry, Articular / Q000009:adverse effects* / Q000295:instrumentation*; D002460:Cell Line; D049109:Cell Proliferation; D004735:Energy Transfer / Q000502:physiology; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006358:Hot Temperature; D006801:Humans; D015603:Keratinocytes / Q000166:cytology / Q000502:physiology*; D011187:Posture / Q000502:physiology*; D019736:Prostheses and Implants / Q000009:adverse effects*; D016059:Range of Motion, Articular / Q000502:physiology*; D013696:Temperature; D014159:Transducers / Q000009:adverse effects*