title: [Cancer research: a privileged field of investigation on chance, reductionism and holism].
abstract: The debate between reductionism and anti-reductionism, dealing with the ultimate constituents of the world, is one of the fundamental issues in the philosophy of science. However, in biology, reductionism is less of an ontological and more of an epistemological question: it argues that the explanation of biological processes resides in deciphering the genetic code of living entities. This position is still prevalent in cancer biology, which has long been defined as a cellular process where genetic alterations are responsible for aberrant proliferation. While the hypothesis of somatic mutations remains the central theoretical model, a bundle of experimental data reveals how important the disturbances of tissue organisation are in cancer development, leading to a renewal of holistic and organicist approaches. This latter perspective in particular attempts to contextualise and rethink the centrality of the genetic level by proposing a new conception of cancerogenesis as a tissue disease.
authors.affiliation: Max Planck Institute for Comparative Public Law and International Law,   - Fondation Maison des sciences de l'homme, la Commission européenne (programme Action Marie Curie, COFUND, 7e PCRD) et la fondation Fritz Thyssen,  
authors.forename: Anna
authors.initials: A
authors.lastname: Zielinska
authors.affiliation: Institut Cochin, université Paris Descartes, CNRS (UMR 8104), Paris, France - Inserm, U1016, Paris, France.
authors.forename: Tarik
authors.initials: T
authors.lastname: Issad
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000379:methods / Q000639:trends; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000473:pathology; D060833:Cellular Microenvironment; D005260:Female; D006801:Humans; D051379:Mice; D008962:Models, Theoretical; D009369:Neoplasms / Q000209:etiology / Q000473:pathology / Q000628:therapy; D009857:Oncogenes / Q000502:physiology; D010684:Philosophy; D011336:Probability; D012306:Risk