title: Different subunits belonging to the same protein complex often exhibit discordant expression levels and evolutionary properties.
abstract: Hetero-oligomeric protein complexes are involved in many of the key processes in cells. Given that the subunits of a complex function together, it has often been expected to find that (i) they are expressed at similar levels in cells; (ii) they are simultaneously present or absent in genomes; and that (iii) the effects on fitness of deleting their genes should be similar. Such a coherence is, however, often found to be weak or absent. Multi-functionality of subunits and mechanisms of complex assembly are discussed as possible sources for the lack of coherence.
authors.affiliation: Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel.
authors.forename: Or
authors.initials: O
authors.lastname: Matalon
authors.affiliation: Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel.
authors.forename: Amnon
authors.initials: A
authors.lastname: Horovitz
authors.affiliation: Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address: emmanuel.levy@weizmann.ac.il.
authors.forename: Emmanuel D
authors.initials: ED
authors.lastname: Levy
mesh_terms: D019143:Evolution, Molecular; D005786:Gene Expression Regulation; D006801:Humans; D010802:Phylogeny; D066329:Protein Aggregates; D021122:Protein Subunits / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D066329:Protein Aggregates; D021122:Protein Subunits