title: The C-1021T polymorphism of dopamine β-hydroxylase is not associated with orthostatic hypotension in a Chinese population.
abstract: To explore the association between the dopamine β-hydroxylase (DBH) gene C-1021T polymorphism and the occurrence of orthostatic hypotension (OH) in Chinese patients, the DBH C-1021T polymorphism was genotyped in 317 patients with OH and 664 age- and sex-matched controls with orthostatic normotension. All subjects underwent an upright posture study for the measurement of orthostatic blood pressure. OH was defined as a drop in blood pressure of 20/10 mm Hg or more within 3 min of assuming the upright posture. The allele frequency of the DBH C-1021T polymorphism in the orthostatic hypotensive group was similar to the orthostatic normotensive group (17.4 versus 14.9%, P>0.05). No statistical significant association was found between the distribution of the C-1021T genotypes and the risk of OH in both the orthostatic hypotensive and orthostatic normotensive groups even after adjustment for demographic parameters. Among the three different genotypes, blood pressure levels did not significantly differ in the general population in this study. The changes in orthostatic systolic or diastolic blood pressures among the different genotype groups were not detected (all P>0.05). The C-1021T polymorphism of the DBH was not associated with orthostatic hypotensive risk in a Chinese population.
authors.affiliation: The Pediatric Cardiology, The First Hospital of Jilin University, Changchun, China.
authors.forename: N
authors.initials: N
authors.lastname: Lu
authors.affiliation: Hypertension Division, The Sino-German Laboratory of Molecular Medicine, Cardiovascular Institute and FuWai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: J
authors.initials: J
authors.lastname: Chen
authors.affiliation: The Anesthesiology Department, The First Hospital of Jilin University, Changchun, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: The Cardiovascular Center, The First Hospital of Jilin University, Changchun, China.
authors.forename: X
authors.initials: X
authors.lastname: Cong
authors.affiliation: The Cardiovascular Center, The First Hospital of Jilin University, Changchun, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
authors.affiliation: The Cardiovascular Center, The First Hospital of Jilin University, Changchun, China.
authors.forename: L
authors.initials: L
authors.lastname: Meng
authors.affiliation: Hypertension Division, The Sino-German Laboratory of Molecular Medicine, Cardiovascular Institute and FuWai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: K
authors.initials: K
authors.lastname: Sun
authors.affiliation: Hypertension Division, The Sino-German Laboratory of Molecular Medicine, Cardiovascular Institute and FuWai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: R
authors.initials: R
authors.lastname: Hui
authors.affiliation: The Cardiovascular Center, The First Hospital of Jilin University, Changchun, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zheng
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D001794:Blood Pressure; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D004299:Dopamine beta-Hydroxylase / Q000235:genetics*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D007024:Hypotension, Orthostatic / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D004299:Dopamine beta-Hydroxylase