title: Use of Extracorporeal Techniques in the Removal of Dabigatran.
abstract: Dabigatran is a novel direct thrombin inhibitor that has proven effective in the prevention of vascular events in patients with nonvalvular atrial fibrillation. Not much is known about the clearance capability with extracorporeal techniques of dabigatran. This review showcases the pharmacokinetics and a perusal of the current literature regarding cases that involved the clearance of the drug in patients with normal renal function and end-stage renal disease. Renal replacement therapy represents a therapeutic option to eliminate dabigatran and decreased the risk of bleeding in patients undergoing emergent surgical procedures on dabigatran.
authors.affiliation: 1Division of Nephrology and Hypertension, Allegheny General Hospital, Temple University School of Medicine, Pittsburgh, PA; and 2Division of Nephrology and Hypertension, University of Miami, Miller School of Medicine, Miami, FL.
authors.forename: Neeharika
authors.initials: N
authors.lastname: Muddana
authors.forename: Culver
authors.initials: C
authors.lastname: Thuyanh
authors.forename: Ali
authors.initials: A
authors.lastname: Nayer
authors.forename: Khaled
authors.initials: K
authors.lastname: Nashar
authors.forename: Luis M
authors.initials: LM
authors.lastname: Ortega
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000991:Antithrombins / Q000493:pharmacokinetics*; D001281:Atrial Fibrillation / Q000188:drug therapy*; D000069604:Dabigatran / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008657:Metabolic Clearance Rate; D006435:Renal Dialysis
chemical_list: D000991:Antithrombins; D000069604:Dabigatran