title: Uniform polydimethylsiloxane beads coated with polydopamine and their potential biomedical applications.
abstract: Based on oil-in-water emulsion, uniform poly(dimethylsiloxane) (PDMS) beads were prepared using a simple fluidic device and then modified with polydopamine (PDA) to improve cell attachment. The size of the PDMS beads could be easily tuned by changing the flow rates of the discontinuous and continuous phases, and PDMS concentration in oil phase. The PDA-coated PDMS beads exhibited a dark and rough surface, whereas the pristine PDMS beads had a clear and smooth surface. The PDA layer at the surface of the PDMS beads was found to provide a favorable environment for cell culture due to its hydrophilic property. The PDA-coated PDMS beads can potentially be employed as filler materials for tissue engineering.
authors.affiliation: Department of Biotechnology, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon, Gyeonggi-do 420-743, Republic of Korea.
authors.forename: Dae-Ryong
authors.initials: DR
authors.lastname: Jun
authors.affiliation: Department of Biotechnology, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon, Gyeonggi-do 420-743, Republic of Korea.
authors.forename: Seung-Kwan
authors.initials: SK
authors.lastname: Moon
authors.affiliation: Department of Biotechnology, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon, Gyeonggi-do 420-743, Republic of Korea. Electronic address: choisw@catholic.ac.kr.
authors.forename: Sung-Wook
authors.initials: SW
authors.lastname: Choi
mesh_terms: D000818:Animals; D020811:Biomedical Technology / Q000379:methods*; D049109:Cell Proliferation / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D004129:Dimethylpolysiloxanes / Q000737:chemistry / Q000494:pharmacology*; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D008856:Microscopy, Fluorescence; D008863:Microspheres; D041681:NIH 3T3 Cells; D010316:Particle Size; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology*; D017550:Spectroscopy, Fourier Transform Infrared; D013194:Staining and Labeling
chemical_list: D020099:Coated Materials, Biocompatible; D004129:Dimethylpolysiloxanes; D007211:Indoles; D011108:Polymers; C568283:polydopamine
keywords: Cell culture; Filler materials; Poly(dimethylsiloxane); Polydopamine; Uniform beads