title: Relationships between testosterone levels and cognition in patients with Alzheimer disease and nondemented elderly men.
abstract: OBJECTIVE
  Previous research suggests that low levels of testosterone may be associated with the development of Alzheimer disease (AD), as well as poorer performance on certain neuropsychological tests and increased risk of depression.
  
  
  METHODS
  This study utilized data from 61 nondemented older men and 68 men with probable AD.
  
  
  RESULTS
  Testosterone levels did not differ between the groups. Regression analyses in men with AD revealed that testosterone levels did not significantly predict performance on neuropsychological tests or a measure of depression. Among controls, testosterone levels predicted estimated premorbid verbal IQ and performance on a verbal fluency test.
  
  
  CONCLUSIONS
  Findings suggest that testosterone is not associated with most neuropsychological test performances in patients with AD.
authors.affiliation: Department of Psychology, University of Houston, Houston, TX, USA jntravis@uh.edu.
authors.forename: Jennifer N Travis
authors.initials: JN
authors.lastname: Seidl
authors.affiliation: Department of Psychology, University of Houston, Houston, TX, USA Department of Neurology, Alzheimer's Disease and Memory Disorders Center, Baylor College of Medicine, Houston, TX, USA.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Massman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood / Q000523:psychology*; D016022:Case-Control Studies; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000097:blood* / Q000209:etiology; D003863:Depression / Q000097:blood / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D011569:Psychiatric Status Rating Scales; D013739:Testosterone / Q000097:blood*; D013781:Texas
chemical_list: D013739:Testosterone
keywords: Alzheimer disease; biomarkers; neuropsychological testing