title: A microfluidic device to select for cells based on chemotactic phenotype.
abstract: In the search for biomarkers of metastasis, attention has been largely placed on ensemble-averaged measurements that screen for molecules or genes. However, individual molecular changes do not always result in disease, and population-based measurements can mask the molecular signatures of the cells responsible for disease. Here, we describe a device that selects for cells based on chemotactic behavior rather than based on molecular differences, enabling the most aggressive cells to be studied independently from the heterogeneous population.
authors.forename: Saumendra
authors.initials: S
authors.lastname: Bajpai
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Mitchell
authors.forename: Michael R
authors.initials: MR
authors.lastname: King
authors.forename: Cynthia A
authors.initials: CA
authors.lastname: Reinhart-King