title: Study of wound healing activity of Tectona grandis Linn. leaf extract on rats.
abstract: OBJECTIVE
  The aim of the study is to determine the wound healing activity of Tectona grandis (TG) Linn. leaf extract on rats.
  
  
  METHODS
  Healthy albino rats (150-200 g) of either sex were taken for excision and incision wound model. Animals were divided into four groups of six animals in each group. For Group simple ointment served as control. The Groups 2 and 3 had 5 and 10% ointment of TG leaf extract and Group 4 soframycin ointment served as standard. In excision wound percentage of wound contraction was assessed, whereas in incision wound tensile strength was assessed. Statistical analysis was performed by one-way analysis of variance followed by t-test.
  
  
  RESULTS
  In excision wound model, 5% ointment of TG leaf extract showed a reduction in wound area 8(th) day onwards. Reduction in wound area was very significant (P < 0.01) as compared to control. Whereas 10% ointment of TG leaf extract and standard showed a reduction in wound area fourth day onwards, which was highly significant (P < 0.001) as compared to control. In incision wound model, animals treated with 5% ointment of TG leaf extract showed significant (P < 0.05) increase in tensile strength as compare to control. However, animals treated with 10% ointment of TG leaf extract showed very significant (P < 0.001) increase in tensile strength as compare with control. However, animals treated with soframycin showed highly significant (P < 0.001) increase in tensile strength as compare with control.
  
  
  CONCLUSIONS
  TG leaf extract showed significant wound healing activity.
authors.affiliation: Departments of Pharmacology and Therapeutics, MGIMS, Sevagram, Wardha, Maharashtra, India.
authors.forename: Sushilkumar B
authors.initials: SB
authors.lastname: Varma
authors.affiliation: ACPM College, Dhule, Maharashtra, India.
authors.forename: Sapna P
authors.initials: SP
authors.lastname: Giri
keywords: Excision wound; Tectona grandis Linn; hydro-alcoholic leaf extract; incision; wound healing