title: Tolerability of propofol in Wada testing.
abstract: OBJECTIVE
  To assess the tolerability of propofol (PF) in Wada test in an Arab population with temporal lobe epilepsy (TLE).
  
  
  METHODS
  This observational study with consecutive sampling took place in King Fahad Medical City, Riyadh, Saudi Arabia. Nine consecutive patients with mean (± SD) age of 26 (± 5.8) years, 6 males and 3 females, underwent Wada test between January 2009 and December 2012. Six of them had left TLE, and 3 had right TLE. Each patient received 10 mg of PF in the internal carotid artery (ICA). Right hemispheric injection was followed by left hemisphere injection after 30 minutes. During the procedure, EEG monitoring showed changes within 5-18 seconds of injection as hemispheric delta slowing. Neuropsychological tests were carried out for localization of memory and language.
  
  
  RESULTS
  We were able to lateralize speech dominance in 8 patients and memory dominance in 6 patients. Peri-procedural complications included transient euphoria (n=1), transient spasm of ICA (n=1), eye pain (n=1), facial pain (n=1), and generalized tremulousness (n=2). None of the patients exhibited a symptomatic drop in blood pressure.
  
  
  CONCLUSIONS
  We found that PF is well tolerable for the Wada test, with minimally significant complications, although blood pressure should be closely monitored.
authors.affiliation: Neurology Department, Neurosciences Institute, King Fahad Medical City, PO Box 59046, Riyadh 11525, Kingdom of Saudi Arabia. Tel. +966 (11) 2889999 Ext. 13975. Fax. +966 (11) 2889999 Ext. 11391. E-mail: faisal_alsallom@hotmail.com / neurology.khurram@yahoo.co.uk.
authors.forename: Faisal A
authors.initials: FA
authors.lastname: Alsallom
authors.forename: Shobhit
authors.initials: S
authors.lastname: Sinha
authors.forename: Fahmi M
authors.initials: FM
authors.lastname: Alsenani
authors.forename: Fawziah A
authors.initials: FA
authors.lastname: Bamogaddam
authors.forename: Saeed H
authors.initials: SH
authors.lastname: Wahass
authors.forename: Aurora B
authors.initials: AB
authors.lastname: Canillo
authors.forename: Khurram A
authors.initials: KA
authors.lastname: Siddiqui
mesh_terms: D000328:Adult; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000009:adverse effects; D018912:Arabs; D001931:Brain Mapping / Q000379:methods*; D004569:Electroencephalography / Q000379:methods*; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects; D013060:Speech; D055815:Young Adult
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol