title: Diagnosis and treatment of SAPHO syndrome: A case report.
abstract: The present study reports a rare case of synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome in an adult male. The 42-year-old man complained of skin lesions, chest pain and lumbago. Laboratory evaluations demonstrated an elevated erythrocyte sedimentation rate and increased levels of C-reactive protein. Computerized tomography, bone scintigraphy and magnetic resonance imaging revealed multiple bone lesions. A diagnosis of SAPHO syndrome was made. Non-steroidal anti-inflammatory drugs, alendronate sodium and steroids were administered, which resulted in clinical improvement. The current case study demonstrates that skin manifestation and multiple imaging modalities are important in generating a definite diagnosis of SAPHO syndrome, and that early treatment is vital for a positive outcome.
authors.affiliation: Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin 300052, P.R.China.
authors.forename: Xinghua
authors.initials: X
authors.lastname: Song
authors.affiliation: Department of Rheumatology and Immunological Diseases, Tianjin Medical University General Hospital, Tianjin 300052, P.R.China.
authors.forename: Wenwen
authors.initials: W
authors.lastname: Sun
authors.affiliation: Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin 300052, P.R.China.
authors.forename: Zhaowei
authors.initials: Z
authors.lastname: Meng
authors.affiliation: Department of Rheumatology and Immunological Diseases, Tianjin Medical University General Hospital, Tianjin 300052, P.R.China.
authors.forename: Lu
authors.initials: L
authors.lastname: Gong
authors.affiliation: Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin 300052, P.R.China.
authors.forename: Jian
authors.initials: J
authors.lastname: Tan
authors.affiliation: Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin 300052, P.R.China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Jia
authors.affiliation: Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300052, P.R.China.
authors.forename: Chunshui
authors.initials: C
authors.lastname: Yu
authors.affiliation: Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300052, P.R.China.
authors.forename: Tielian
authors.initials: T
authors.lastname: Yu
keywords: acne; hyperostosis and osteitis syndrome; multiple imaging modalities; pustulosis; skin lesions; synovitis