title: Mitomycin-C for mucous membrane overgrowth in OOKP eyes.
abstract: OBJECTIVE
  The aim of this study was to report the use of mitomycin-C (MMC) in the treatment of mucous membrane overgrowth in eyes with osteo-odonto-keratoprosthesis (OOKP).
  
  
  METHODS
  Records of 4 cases with mucous membrane overgrowth after stage 2 OOKP surgery were reviewed.
  
  
  RESULTS
  All the patients had undergone a mucous membrane trimming procedure followed by MMC application. None of the patients had any episode of recurrence of the mucous membrane overgrowth after a single application of MMC in the follow-up period that ranged from 1 to 11 years.
  
  
  CONCLUSIONS
  MMC can successfully arrest mucous membrane overgrowth in OOKP-implanted eyes including refractory cases.
authors.affiliation: *Sussex Eye Hospital, Brighton, United Kingdom; †Brighton and Sussex Medical School, Brighton, United Kingdom; ‡Royal Sussex County Hospital, Brighton, United Kingdom; and §Tongdean Eye Clinic, Hove, United Kingdom.
authors.forename: Venkata S
authors.initials: VS
authors.lastname: Avadhanam
authors.forename: Jim
authors.initials: J
authors.lastname: Herold
authors.forename: Simon
authors.initials: S
authors.lastname: Thorp
authors.forename: Christopher S C
authors.initials: CS
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000477:Alkylating Agents / Q000627:therapeutic use*; D000539:Alveolar Process / Q000637:transplantation; D001705:Bioprosthesis; D016039:Corneal Transplantation; D005260:Female; D006801:Humans; D006984:Hypertrophy / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use*; D009061:Mouth Mucosa / Q000187:drug effects* / Q000473:pathology* / Q000637:transplantation; D013262:Stevens-Johnson Syndrome / Q000601:surgery*; D014092:Tooth Root / Q000637:transplantation
chemical_list: D000477:Alkylating Agents; D016685:Mitomycin