title: Your heart on a chip: iPSC-based modeling of Barth-syndrome-associated cardiomyopathy.
abstract: Disease-specific induced pluripotent stem cells (iPSCs) are invaluable tools for studying genetic disorders in a dish. A recent paper by Wang et al. (2014) powerfully combines analysis of human iPSCs with genome editing and tissue engineering, in conjunction with biochemical and physiological assays, to provide insights into Barth-syndrome-associated cardiomyopathy.
authors.affiliation: Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, 30625 Hannover, Germany; REBIRTH Cluster of Excellence.
authors.forename: Robert
authors.initials: R
authors.lastname: Zweigerdt
authors.affiliation: Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, 30625 Hannover, Germany; REBIRTH Cluster of Excellence.
authors.forename: Ina
authors.initials: I
authors.lastname: Gruh
authors.affiliation: Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, 30625 Hannover, Germany; REBIRTH Cluster of Excellence. Electronic address: martin.ulrich@mh-hannover.de.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Martin
mesh_terms: D056889:Barth Syndrome / Q000503:physiopathology*; D002311:Cardiomyopathy, Dilated / Q000503:physiopathology*; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000502:physiology*; D028361:Mitochondrial Diseases / Q000503:physiopathology*; D008954:Models, Biological; D023822:Tissue Engineering / Q000379:methods*; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D014157:Transcription Factors