title: CR1 is potentially associated with rate of decline in sporadic Alzheimer's disease.
abstract: The objective of this study was to investigate potential associations of Alzheimer's disease risk single nucleotide polymorphisms (SNP) with disease progression. SNP in ACE, ApoE, BIN1, CLU, CR1, CST3, EXOC3L2, GWA14q32.13, IL8, LDLR, PICALM, and TNK1 were determined in 40 Alzheimer's disease patients who were observed for 2 to 3 years. Annual Mini Mental State Examination (MMSE) loss was used as the outcome parameter in multiple regression analyses. Regarding a CR1 SNP (rs3818361) G-allele carriers featured faster declines (approximately 3 MMSE points per year). To summarize, in addition to being a risk factor for Alzheimer's disease development, a CR1 SNP appears to be associated with higher rates of medium-term disease progression. Therefore, it may serve as a prognostic marker (among others) and may aid in differentiating slow from fast progressors early in the disease course.
authors.affiliation: Department of Neurology, Clinical Dementia Center, Georg August University Medical Center, Robert-Koch-Str. 40, 37075 Goettingen, Germany. Electronic address: cschmid2@gwdg.de.
authors.forename: Christian
authors.initials: C
authors.lastname: Schmidt
authors.affiliation: Department of Neurology, Clinical Dementia Center, Georg August University Medical Center, Robert-Koch-Str. 40, 37075 Goettingen, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Wolff
authors.affiliation: Department of Clinical Chemistry, Georg August University Medical Center, Goettingen, Germany.
authors.forename: Nicolas
authors.initials: N
authors.lastname: von Ahsen
authors.affiliation: Department of Statistics and Bioinformatics, Georg August University Medical Center, Goettingen, Germany.
authors.forename: Katharina
authors.initials: K
authors.lastname: Lange
authors.affiliation: Department of Statistics and Bioinformatics, Georg August University Medical Center, Goettingen, Germany.
authors.forename: Tim
authors.initials: T
authors.lastname: Friede
authors.affiliation: Department of Neurology, Clinical Dementia Center, Georg August University Medical Center, Robert-Koch-Str. 40, 37075 Goettingen, Germany; DZNE - German Center for Neurodegenerative Diseases, Germany.
authors.forename: Inga
authors.initials: I
authors.lastname: Zerr
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics* / Q000503:physiopathology; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D060005:Genotyping Techniques; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D011569:Psychiatric Status Rating Scales; D017463:Receptors, Complement 3b / Q000235:genetics*; D012044:Regression Analysis
chemical_list: C509991:CR1 protein, human; D017463:Receptors, Complement 3b
keywords: Alzheimer; CR1; Polymorphism; Progression; SNP