title: Association of fruit and vegetables with the risk of nasopharyngeal cancer: evidence from a meta-analysis.
abstract: Quantification of the association between the intake of vegetables and fruit and risk of nasopharyngeal cancer (NPC) is controversial. Thus, we conducted a meta-analysis to assess the relationship between vegetables and fruit and NPC risk. Pertinent studies were identified by a search in PubMed, Web of Knowledge and Wan Fang Med Online. Random-effects models were used to calculate summary relative risks (RRs) and the corresponding 95% confidence intervals (CIs). Publication bias was estimated using Egger's regression asymmetry test. Finally, 15 articles comprising 8208 NPC cases were included in this meta-analysis. The combined results showed that there was significant association between vegetables and fruit intake and NPC risk. The pooled RRs were 0.60 (95% CI = 0.47-0.76) for vegetables and 0.63 (95% CI = 0.56-0.70) for fruit. No publication bias was detected. Our analysis indicated that intake of vegetables and fruit may have a protective effect on NPC. Since the potential biases and confounders could not be ruled out completely in this meta-analysis, further studies are needed.
authors.affiliation: 1] Department of Otorhinolaryngology, The Central Hospital of Yiwu City(Affiliated Hospital of Wen Zhou Medical University), Yiwu 322000, China [2].
authors.forename: Jian
authors.initials: J
authors.lastname: Jin
authors.affiliation: 1] Department of Otorhinolaryngology, The Central Hospital of Yiwu City(Affiliated Hospital of Wen Zhou Medical University), Yiwu 322000, China [2].
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Ouyang
authors.affiliation: 1] Department of Otolaryngology Head and Neck Surgery, Xinhua Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China, 200092 [2] Ear Institute, Shanghai Jiao Tong University, School of Medicine, Shanghai, China, 200092.
authors.forename: Zhaoyan
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma; D016022:Case-Control Studies; D015331:Cohort Studies; D004032:Diet; D005260:Female; D005638:Fruit; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000209:etiology*; D012306:Risk; D012307:Risk Factors; D014675:Vegetables; D055815:Young Adult