title: Trafficking mechanisms and regulation of TRPC channels.
abstract: TRPC channels are Ca(2+)-permeable cation channels which are regulated downstream from receptor-coupled PIP2 hydrolysis. These channels contribute to a wide variety of cellular functions. Loss or gain of channel function has been associated with dysfunction and aberrant physiology. TRPC channel functions are influenced by their physical and functional interactions with numerous proteins that determine their regulation, scaffolding, trafficking, as well as their effects on the downstream cellular processes. Such interactions also compartmentalize the Ca(2+) signals arising from TRPC channels. A large number of studies demonstrate that trafficking is a critical mode by which plasma membrane localization and surface expression of TRPC channels are regulated. This review will provide an overview of intracellular trafficking pathways as well as discuss the current state of knowledge regarding the mechanisms and components involved in trafficking of the seven members of the TRPC family (TRPC1-TRPC7).
authors.affiliation: Secretory Physiology Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, United States. Electronic address: lorena.britodesouza@nih.gov.
authors.forename: Lorena Brito
authors.initials: LB
authors.lastname: de  Souza
authors.affiliation: Secretory Physiology Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, United States. Electronic address: indu.ambudkar@nih.gov.
authors.forename: Indu S
authors.initials: IS
authors.lastname: Ambudkar
mesh_terms: D020013:Calcium Signaling; D006801:Humans; D021962:Membrane Microdomains / Q000378:metabolism; D021381:Protein Transport / Q000502:physiology; D050600:SNARE Proteins / Q000378:metabolism; D022142:Secretory Vesicles / Q000378:metabolism; D050052:TRPC Cation Channels / Q000378:metabolism*
chemical_list: D050600:SNARE Proteins; D050052:TRPC Cation Channels
keywords: Ca(2+) signaling; Intracellular trafficking; Microdomains; Regulation; TRPC channels