title: Physico-chemical state influences in vitro release profile of curcumin from pectin beads.
abstract: Curcumin is a polyphenolic compound with diverse effects interesting to develop health benefit products but its formulation in functional foods or in food supplement is hampered by its poor water solubility and susceptibility to alkaline conditions, light, oxidation and heat. Encapsulation of curcumin could be a mean to overcome these difficulties. In this paper, curcumin was encapsulated by ionotropic gelation method in low methoxyl pectin beads associated with different surfactants: Solutol(®), Transcutol(®) and sodium caseinate. After encapsulation, physico-chemical properties of encapsulated curcumin such as its solubility, physical state, tautomeric forms and encapsulation efficiency as well as encapsulation yield were characterized. In vitro dissolution of curcumin from beads displayed different kinetic profiles according to bead composition due to different matrix network. As Solutol(®) was a good solvent for curcumin, the drug was present into amorphous form in these beads inducing a rapid release of curcumin in the simulated digestive fluids. In contrast, drug release was slower from sodium caseinate beads since curcumin was not totally dissolved during the manufacturing process. Moreover, the FLIM studies showed that a part of curcumin was encapsulated in caseinate micelles and that 34% of this drug was in keto form which may delay the curcumin release. The Transcutol beads showed also a slow drug release because of the low curcumin solubility and the high density of the matrix.
authors.affiliation: UMR PAM Université de Bourgogne/AgroSup Dijon, 1 Esplanade Erasme, 21000 Dijon, France.
authors.forename: An Thi-Binh
authors.initials: AT
authors.lastname: Nguyen
authors.affiliation: UMR PAM Université de Bourgogne/AgroSup Dijon, 1 Esplanade Erasme, 21000 Dijon, France; Spectral Imaging Resource Center (PIMS), DIMACELL, PMB Team, AgroSup Dijon, 1 Esplanade Erasme, Dijon, France.
authors.forename: Pascale
authors.initials: P
authors.lastname: Winckler
authors.affiliation: UMR PAM Université de Bourgogne/AgroSup Dijon, 1 Esplanade Erasme, 21000 Dijon, France.
authors.forename: Pauline
authors.initials: P
authors.lastname: Loison
authors.affiliation: UMR PAM Université de Bourgogne/AgroSup Dijon, 1 Esplanade Erasme, 21000 Dijon, France; Spectral Imaging Resource Center (PIMS), DIMACELL, PMB Team, AgroSup Dijon, 1 Esplanade Erasme, Dijon, France.
authors.forename: Yves
authors.initials: Y
authors.lastname: Wache
authors.affiliation: UMR PAM Université de Bourgogne/AgroSup Dijon, 1 Esplanade Erasme, 21000 Dijon, France; Department of Pharmaceutical Technology, PAPC Team, School of Pharmacy, Université de Bourgogne, 7 bd Jeanne d'Arc, 21079 Dijon, France. Electronic address: odile.chambin@u-bourgogne.fr.
authors.forename: Odile
authors.initials: O
authors.lastname: Chambin
mesh_terms: D000818:Animals; D001826:Body Fluids / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D003474:Curcumin / Q000737:chemistry* / Q000494:pharmacology*; D007700:Kinetics; D008856:Microscopy, Fluorescence; D008863:Microspheres; D010368:Pectins / Q000737:chemistry*; D051381:Rats; D012995:Solubility; D013237:Stereoisomerism
chemical_list: D010368:Pectins; D003474:Curcumin
keywords: Curcumin; Encapsulation; FLIM studies; In vitro release; Ionotropic gelation method; Physico-chemical state