title: Ziprasidone as adjunctive therapy in severe bipolar patients treated with clozapine.
abstract: Aim. To confirm the efficacy and tolerability of ziprasidone as adjunctive therapy in bipolar patients partially responding to clozapine or with persisting negative symptoms, overweight, or with metabolic syndrome. Methods. Eight patients with psychotic bipolar disorder were tested with the BPRS, the HAM-D, and the CGI at T0 and retested after 2 weeks (T1). Plasma clozapine and norclozapine levels and BMI were tested at T0 and T1. Results. Ziprasidone was well tolerated by all the patients. BPRS and HAM-D scores were reduced in all patients. BMI was reduced in patients with a BMI at T0 higher than 25. Plasma levels of clozapine and norclozapine showed an irregular course.
authors.affiliation: Dipartimento di Medicina Clinica e Sperimentale, Sezione di Psichiatria, Università di Pisa, Azienda Ospedaliero-Universitaria Pisana, Via Roma, No. 67, 56126 Pisa, Italy.
authors.forename: Natalia
authors.initials: N
authors.lastname: Bartolommei
authors.affiliation: Dipartimento di Medicina Clinica e Sperimentale, Sezione di Psichiatria, Università di Pisa, Azienda Ospedaliero-Universitaria Pisana, Via Roma, No. 67, 56126 Pisa, Italy.
authors.forename: Francesco
authors.identifier: 0000-0001-6529-962X
authors.initials: F
authors.lastname: Casamassima
authors.affiliation: Dipartimento di Medicina Clinica e Sperimentale, Sezione di Psichiatria, Università di Pisa, Azienda Ospedaliero-Universitaria Pisana, Via Roma, No. 67, 56126 Pisa, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Pensabene
authors.affiliation: Dipartimento di Medicina Clinica e Sperimentale, Sezione di Psichiatria, Università di Pisa, Azienda Ospedaliero-Universitaria Pisana, Via Roma, No. 67, 56126 Pisa, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Luchini
authors.affiliation: Dipartimento di Medicina Clinica e Sperimentale, Sezione di Psichiatria, Università di Pisa, Azienda Ospedaliero-Universitaria Pisana, Via Roma, No. 67, 56126 Pisa, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Benvenuti
authors.affiliation: Dipartimento di Medicina Clinica e Sperimentale, Sezione di Psichiatria, Università di Pisa, Azienda Ospedaliero-Universitaria Pisana, Via Roma, No. 67, 56126 Pisa, Italy.
authors.forename: Antonello
authors.initials: A
authors.lastname: Di Paolo
authors.affiliation: Dipartimento di Medicina Clinica e Sperimentale, Sezione di Psichiatria, Università di Pisa, Azienda Ospedaliero-Universitaria Pisana, Via Roma, No. 67, 56126 Pisa, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Cosentino
authors.affiliation: Dipartimento di Medicina Clinica e Sperimentale, Sezione di Psichiatria, Università di Pisa, Azienda Ospedaliero-Universitaria Pisana, Via Roma, No. 67, 56126 Pisa, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Mauri
authors.affiliation: Dipartimento di Medicina Clinica e Sperimentale, Sezione di Psichiatria, Università di Pisa, Azienda Ospedaliero-Universitaria Pisana, Via Roma, No. 67, 56126 Pisa, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Lattanzi