title: Genome wide association scan for chronic periodontitis implicates novel locus.
abstract: BACKGROUND
  There is evidence for a genetic contribution to chronic periodontitis. In this study, we conducted a genome wide association study among 866 participants of the University of Pittsburgh Dental Registry and DNA Repository, whose periodontal diagnosis ranged from healthy (N = 767) to severe chronic periodontitis (N = 99).
  
  
  METHODS
  Genotypingi of over half-million single nucleotide polymorphisms was determined. Analyses were done twice, first in the complete dataset of all ethnicities, and second including only samples defined as self-reported Whites. From the top 100 results, twenty single nucleotide polymorphisms had consistent results in both analyses (borderline p-values ranging from 1E-05 to 1E-6) and were selected to be tested in two independent datasets derived from 1,460 individuals from Porto Alegre, and 359 from Rio de Janeiro, Brazil. Meta-analyses of the Single nucleotide polymorphisms showing a trend for association in the independent dataset were performed.
  
  
  RESULTS
  The rs1477403 marker located on 16q22.3 showed suggestive association in the discovery phase and in the Porto Alegre dataset (p = 0.05). The meta-analysis suggested the less common allele decreases the risk of chronic periodontitis.
  
  
  CONCLUSIONS
  Our data offer a clear hypothesis to be independently tested regarding the contribution of the 16q22.3 locus to chronic periodontitis.
authors.forename: Ping
authors.initials: P
authors.lastname: Feng
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Wang
authors.forename: Priscila L
authors.initials: PL
authors.lastname: Casado
authors.forename: Erika C
authors.initials: EC
authors.lastname: Küchler
authors.forename: Kathleen
authors.initials: K
authors.lastname: Deeley
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Noel
authors.forename: Hyongsup
authors.initials: H
authors.lastname: Kimm
authors.forename: Ji-Hye
authors.initials: JH
authors.lastname: Kim
authors.forename: Alex N
authors.initials: AN
authors.lastname: Haas
authors.forename: Valquiria
authors.initials: V
authors.lastname: Quinelato
authors.forename: Leticia L
authors.initials: LL
authors.lastname: Bonato
authors.forename: Jose M
authors.initials: JM
authors.lastname: Granjeiro
authors.forename: Cristiano
authors.initials: C
authors.lastname: Susin
authors.affiliation: Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, 3501 Terrace Street, Pittsburgh, PA 15261, USA. arv11@pitt.edu.
authors.forename: Alexandre R
authors.initials: AR
authors.lastname: Vieira
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics*; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics; D055113:Chronic Periodontitis / Q000208:ethnology / Q000235:genetics*; D048909:Diabetes Complications; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012307:Risk Factors; D012907:Smoking; D044465:White People / Q000235:genetics
chemical_list: D005819:Genetic Markers