title: Flavonoids and Wnt/β-catenin signaling: potential role in colorectal cancer therapies.
abstract: It is now well documented that natural products have played an important role in anticancer therapy. Many studies focus on the ability of these natural compounds to modulate tumor-related signaling pathways and the relationship of these properties to an anticancer effect. According to the World Health Organization (WHO), colorectal cancer (CRC) is the third most common cancer and the fourth leading cause of cancer death among men and women. Therefore, finding strategies to fight against CRC is an emergent health problem. CRC has a strong association with deregulation of Wnt/β-catenin signaling pathway. As some types of natural compounds are capable of modulating the Wnt/β-catenin signaling, one important question is whether they could counteract CRC. In this review, we discuss the role of flavonoids, a class of natural compounds, on Wnt/β-catenin regulation and its possible potential for therapeutic usage on colorectal cancer.
authors.affiliation: Biomedical Science Institute, Federal University of Rio de Janeiro, Bloco F2 Sala 15, Rio de Janeiro 21949-590, Brazil. nathalia@icb.ufrj.br.
authors.forename: Nathália G
authors.initials: NG
authors.lastname: Amado
authors.affiliation: Biomedical Science Institute, Federal University of Rio de Janeiro, Bloco F2 Sala 15, Rio de Janeiro 21949-590, Brazil. danilopredes@gmail.com.
authors.forename: Danilo
authors.initials: D
authors.lastname: Predes
authors.affiliation: Biomedical Science Institute, Federal University of Rio de Janeiro, Bloco F2 Sala 15, Rio de Janeiro 21949-590, Brazil. celammoreno@gmail.com.
authors.forename: Marcela M
authors.initials: MM
authors.lastname: Moreno
authors.affiliation: Biomedical Science Institute, Federal University of Rio de Janeiro, Bloco F2 Sala 15, Rio de Janeiro 21949-590, Brazil. igor.oliveira93@outlook.com.
authors.forename: Igor O
authors.initials: IO
authors.lastname: Carvalho
authors.affiliation: Biomedical Science Institute, Federal University of Rio de Janeiro, Bloco F2 Sala 15, Rio de Janeiro 21949-590, Brazil. mendes@icb.ufrj.br.
authors.forename: Fábio A
authors.initials: FA
authors.lastname: Mendes
authors.affiliation: Biomedical Science Institute, Federal University of Rio de Janeiro, Bloco F2 Sala 15, Rio de Janeiro 21949-590, Brazil. garciajr@icb.ufrj.br.
authors.forename: José G
authors.initials: JG
authors.lastname: Abreu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D005419:Flavonoids / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D051153:Wnt Proteins / Q000235:genetics / Q000378:metabolism*; D060449:Wnt Signaling Pathway / Q000187:drug effects*; D051176:beta Catenin / Q000235:genetics / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D005419:Flavonoids; D051153:Wnt Proteins; D051176:beta Catenin