title: Towards understanding mechanisms governing cytotoxicity of metal oxides nanoparticles: hints from nano-QSAR studies.
abstract: The production of nanomaterials increases every year exponentially and therefore the probability these novel materials that they could cause adverse outcomes for human health and the environment also expands rapidly. We proposed two types of mechanisms of toxic action that are collectively applied in a nano-QSAR model, which provides governance over the toxicity of metal oxide nanoparticles to the human keratinocyte cell line (HaCaT). The combined experimental-theoretical studies allowed the development of an interpretative nano-QSAR model describing the toxicity of 18 nano-metal oxides to the HaCaT cell line, which is a common in vitro model for keratinocyte response during toxic dermal exposure. The comparison of the toxicity of metal oxide nanoparticles to bacteria Escherichia coli (prokaryotic system) and a human keratinocyte cell line (eukaryotic system), resulted in the hypothesis that different modes of toxic action occur between prokaryotic and eukaryotic systems.
authors.affiliation: Laboratory of Environmental Chemometrics, Institute for Environmental and Human Health Protection, Faculty of Chemistry, University of Gdańsk , Gdańsk , Poland .
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Gajewicz
authors.forename: Nicole
authors.initials: N
authors.lastname: Schaeublin
authors.forename: Bakhtiyor
authors.initials: B
authors.lastname: Rasulev
authors.forename: Saber
authors.initials: S
authors.lastname: Hussain
authors.forename: Danuta
authors.initials: D
authors.lastname: Leszczynska
authors.forename: Tomasz
authors.initials: T
authors.lastname: Puzyn
authors.forename: Jerzy
authors.initials: J
authors.lastname: Leszczynski
mesh_terms: D002460:Cell Line; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects; D053768:Metal Nanoparticles / Q000737:chemistry / Q000633:toxicity*; D046529:Microscopy, Electron, Transmission; D010087:Oxides / Q000737:chemistry*; D021281:Quantitative Structure-Activity Relationship
chemical_list: D010087:Oxides
keywords: HaCaT; nano-QSAR; nano-metal oxides; nanoparticles; toxicity