title: Secondary hyperoxaluria: a risk factor for kidney stone formation and renal failure in native kidneys and renal grafts.
abstract: Secondary hyperoxaluria is a multifactorial disease affecting several organs and tissues, among which stand native and transplanted kidneys. Nephrocalcinosis and nephrolithiasis may lead to renal insufficiency. Patients suffering from secondary hyperoxaluria, should be promptly identified and appropriately treated, so that less renal damage occurs. The aim of this review is to underline the causes of hyperoxaluria and the related pathophysiologic mechanisms, which are involved, along with the description of seven cases of irreversible renal graft injury due to secondary hyperoxaluria.
authors.affiliation: Transplantation Unit, Laiko General Hospital, Medical School of Athens, Athens, Greece. Electronic address: drgikaraolanis@gmail.com.
authors.forename: Georgios
authors.initials: G
authors.lastname: Karaolanis
authors.affiliation: Nephrology and Transplantation Unit, Laiko Hospital, Athens, Greece.
authors.forename: Sophia
authors.initials: S
authors.lastname: Lionaki
authors.affiliation: Transplantation Unit, Laiko General Hospital, Medical School of Athens, Athens, Greece.
authors.forename: Demetrios
authors.initials: D
authors.lastname: Moris
authors.affiliation: Transplantation Unit, Laiko General Hospital, Medical School of Athens, Athens, Greece.
authors.forename: Viktoria-Varvara
authors.initials: VV
authors.lastname: Palla
authors.affiliation: Transplantation Unit, Laiko General Hospital, Medical School of Athens, Athens, Greece.
authors.forename: Spiridon
authors.initials: S
authors.lastname: Vernadakis
mesh_terms: D003937:Diagnosis, Differential; D018450:Disease Progression; D006801:Humans; D006959:Hyperoxaluria / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D007669:Kidney Calculi / Q000453:epidemiology; D007676:Kidney Failure, Chronic / Q000473:pathology; D016030:Kidney Transplantation; D008286:Malabsorption Syndromes / Q000150:complications; D051437:Renal Insufficiency / Q000453:epidemiology*; D012307:Risk Factors