title: No association between Y chromosomal haplogroups and severe acne in the Han Chinese population.
abstract: Severe acne presents sexual dimorphism in its incidence in Chinese population. It is more prevalent in males. To assess the possible Y chromosomal contribution to severe acne risk in Han Chinese males, we analyzed 2041 Y chromosomal SNPs (Y-SNPs) in 725 severe acne cases and 651 controls retrieved from our recent genome-wide association study data. After data filtering, we assigned 585 cases and 494 controls into 12 Y chromosomal haplogroups based on 307 high-confidence Y-SNPs. No statistically significant difference in the distribution of Y chromosomal haplogroup frequencies was observed between the case and control groups. Our results showed a lack of association between the incidence of severe acne and the different Y chromosomal haplogroup in the Han Chinese population.
authors.affiliation: Kunming Medical University, and Institute of Dermatology & Venereology of Yunnan Province, Kunming, China.
authors.forename: Mei-Hua
authors.initials: MH
authors.lastname: Guo
authors.affiliation: Kunming Medical University, and Institute of Dermatology & Venereology of Yunnan Province, Kunming, China.
authors.forename: Wen-Juan
authors.initials: WJ
authors.lastname: Wu
authors.affiliation: KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming, China.
authors.forename: Long
authors.initials: L
authors.lastname: Fan
authors.affiliation: 1] KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming, China [2] State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
authors.forename: Min-Sheng
authors.initials: MS
authors.lastname: Peng
authors.affiliation: 1] State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China [2] Laboratory for Conservation and Utilization of Bio-Resources & Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming, China.
authors.forename: Jian-Kang
authors.initials: JK
authors.lastname: Yang
authors.affiliation: 1] KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming, China [2] Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Hao
authors.affiliation: Department of Dermatology, Xiangya Hospital Central South University, Changsha, China.
authors.forename: Hong-Fu
authors.initials: HF
authors.lastname: Xie
authors.affiliation: Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Lei-Hong
authors.initials: LH
authors.lastname: Xiang
authors.affiliation: Department of Dermatology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Min
authors.initials: M
authors.lastname: Zheng
authors.affiliation: Department of Dermatology, Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
authors.forename: Yan-Ni
authors.initials: YN
authors.lastname: Guo
authors.affiliation: Department of Dermatology, Peking University Third Hospital, Beijing, China.
authors.forename: Qing-Hua
authors.initials: QH
authors.lastname: Song
authors.affiliation: Department of Dermatology, The Second Hospital of Dalian Medical University, Dalian, China.
authors.forename: Cai-Xia
authors.initials: CX
authors.lastname: Tu
authors.affiliation: Department of Dermatology, Qilu Hospital of Shandong University, Jinan, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Zhong
authors.affiliation: Department of Dermatology, Changshu NO.1 People's Hospital, Changshu, China.
authors.forename: Wen-Ge
authors.initials: WG
authors.lastname: Fan
authors.affiliation: Department of Dermatology, Dalian Dermatosis Hospital, Dalian, China.
authors.forename: Yue-Jun
authors.initials: YJ
authors.lastname: Shi
authors.affiliation: Department of Dermatology, First people's Hospital of Yunnan Province, Kunming, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Cao
authors.affiliation: Yuxi Lianyuan Hospital, Yuxi, China.
authors.forename: Lian-Yuan
authors.initials: LY
authors.lastname: Feng
authors.affiliation: Department of Dermatology, Kaiyuan People's Hospital, Kaiyuan, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Na
authors.affiliation: Winona Dermo-Cosmetology Center, Kunming, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Pang
authors.affiliation: Winona Dermo-Cosmetology Center, Kunming, China.
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Yang
authors.affiliation: Winona Dermo-Cosmetology Center, Kunming, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Yang
authors.affiliation: Winona Dermo-Cosmetology Center, Kunming, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Zou
authors.affiliation: Kunming Medical University, and Institute of Dermatology & Venereology of Yunnan Province, Kunming, China.
authors.forename: Li
authors.initials: L
authors.lastname: He
authors.affiliation: 1] KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming, China [2] State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China [3] Laboratory for Conservation and Utilization of Bio-Resources & Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming, China.
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Zhang
mesh_terms: D000152:Acne Vulgaris / Q000453:epidemiology / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D041322:Chromosomes, Human, Y / Q000235:genetics*; D055106:Genome-Wide Association Study; D006239:Haplotypes; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*