title: Massive pulmonary embolism and cardiac arrest; thrombolytic therapy in a patient with recent intracranial surgery and glioblastoma multiforme.
abstract: Treatment options for pulmonary embolism are increasing, but the scale of the treatments and their availability in the emergency department (ED) are limited. Thrombolytic therapy remains the most commonly used treatment in patients who present a massive pulmonary embolism in the ED. However, systemic thrombolysis is contraindicated in certain cases, such as a known intracranial tumor or a history of cranial surgery.In this case report, we report a 63-year-old man with a history of intracranial surgery due to glioblastoma multiforme 20 days prior to being admitted to the ED. Multidetector-row computed tomography angiography revealed embolisms in both main pulmonary arteries.There was a progression of cardiac arrest while preparing for catheterization; thus, cardiopulmonary resuscitation was initiated.After administering 10 minutes of cardiopulmonary resuscitation, a50-mg alteplase bolus was given. Within minutes, a pulse has returned. No complications associated with the thrombolytic therapy were observed.Our aim was to discuss the management of massive pulmonary embolism with a contraindication to systemic thrombolytic therapy.
authors.affiliation: Dokuz Eylul University, School of Medicine, Department of Emergency Medicine, Balcova, 35340 Izmir, Turkey. Electronic address: basakdr@yahoo.com.
authors.forename: Başak
authors.initials: B
authors.lastname: Bayram
authors.affiliation: Dokuz Eylul University, School of Medicine, Department of Emergency Medicine, Balcova, 35340 Izmir, Turkey. Electronic address: nese.oray@deu.edu.tr.
authors.forename: Neşe Çolak
authors.initials: NÇ
authors.lastname: Oray
authors.affiliation: Dokuz Eylul University, School of Medicine, Department of Emergency Medicine, Balcova, 35340 Izmir, Turkey. Electronic address: emel.korkmaz@deu.edu.tr.
authors.forename: Emel
authors.initials: E
authors.lastname: Korkmaz
authors.affiliation: Dokuz Eylul University, School of Medicine, Departments of Anesthesiology and Reanimation, Balcova, 35340 Izmir, Turkey. Electronic address: hale.erdost@deu.edu.tr.
authors.forename: Hale Aksu
authors.initials: HA
authors.lastname: Erdost
authors.affiliation: Dokuz Eylul University, School of Medicine, Departments of Anesthesiology and Reanimation, Balcova, 35340 Izmir, Turkey. Electronic address: necati.gokmen@deu.edu.tr.
authors.forename: Necati
authors.initials: N
authors.lastname: Gokmen
mesh_terms: D001932:Brain Neoplasms / Q000601:surgery*; D016887:Cardiopulmonary Resuscitation; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D005909:Glioblastoma / Q000601:surgery*; D006323:Heart Arrest / Q000209:etiology* / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000188:drug therapy* / Q000209:etiology*; D015912:Thrombolytic Therapy / Q000379:methods*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator