title: [Acid-base homeostasis: metabolic acidosis and metabolic alkalosis].
abstract: Acid-base homeostasis ensured by the kidneys, which maintain the equilibrium between proton generation by cellular metabolism and proton excretion in urine. This requirement is lifesaving because of the protons' ability to bind to anionic proteins in the extracellular space, modifying their structure and functions. The kidneys also regenerate bicarbonates. The kidney is not the sole organ in charge of maintaining blood pH in a very narrow range; lungs are also involved since they allow a large amount of volatile acid generated by cellular respiration to be eliminated.
authors.affiliation: Centre de néphrologie et de transplantation rénale, hôpital de la Conception, 147, boulevard Baille, 13385 Marseille cedex 05, France. Electronic address: bertrand.dussol@ap-hm.fr.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Dussol
mesh_terms: D000136:Acid-Base Equilibrium / Q000502:physiology*; D000138:Acidosis / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D003663:Decision Trees; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000502:physiology; D008168:Lung / Q000502:physiology
keywords: Acid-base homeostasis; Acidité titrable; Acidose métabolique; Alcalose métabolique; Ammonium; Bicarbonate; Buffers; Ions ammoniums; Metabolic acidosis; Metabolic alkalosis; Proton; Protons; Tampons; Titratable acid; Équilibre acide-base