title: [Increased body mass index in young adults is associated with metabolic syndrome].
abstract: OBJECTIVE
  Specific Health Examinations and Guidance (Tokutei kenko shinsa/Tokutei hoken shido) are provided for people over 40 years of age to reduce the incidence of metabolic syndrome (MetS). In the present study, we evaluated the importance of weight control in people below 40 years of age.
  
  
  METHODS
  Male subjects (n = 877), aged 30 years, without MetS, were examined. Subjects were classified into 3 groups based on body mass index (BMI): non-obese (BMI < 22), pre-obese (22 ≤ BMI < 25), and obese (BMI ≥ 25). Cox proportional hazards regression analysis was performed for each group to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) for the incidence of MetS in individuals in their 40s on the basis of changes in their BMI, systolic blood pressure, diastolic blood pressure, fasting plasma glucose, high-density lipoprotein, and triglyceride levels between 30 and 35 years of age. In addition, subjects were classified into 3 sub-groups based on changes in BMI: stable-decrease (BMI change < 1), slight increase (1 ≤ BMI increase<2), and increase (2 ≤ BMI increase). HRs for the 3 BMI change sub-groups for MetS were calculated for non-obese and pre-obese subjects.
  
  
  RESULTS
  There was a significant association between changes in BMI and the incidence of MetS for non-obese individuals in their 40s (HR: 2.80, 95% CI: 1.61-4.88) and pre-obese subjects (HR: 2.00, 95% CI: 1.44-2.77). There were also significant associations between the stable/decrease and increase (HR: 9.39, 95% CI: 1.52-57.70) sub-groups and MetS in the non-obese group, as well as for the slight increase (HR: 2.30, 95% CI: 1.03-5.11) and increase (HR: 10.13, 95% CI: 4.30-23.80) sub-groups in the pre-obese group.
  
  
  CONCLUSIONS
  BMI change in young adults is an important risk factor for MetS among individuals in their 40s. Even subjects with a BMI lower than 25 had differences in the risk of developing MetS based on their BMI change sub-group. In the field of occupational health, it will be necessary to promote stable weight control in young adults to reduce the incidence of MetS.
authors.affiliation: Health Service Station, Eco Solutions Company, Panasonic Corporation, 1048 Kadoma, Kadoma City, Osaka 571-8686, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Kadoya
authors.forename: Shinobu
authors.initials: S
authors.lastname: Nakamura
authors.forename: Yuka
authors.initials: Y
authors.lastname: Sugio
authors.forename: Hiroko
authors.initials: H
authors.lastname: Hiraoka
authors.forename: Megumi
authors.initials: M
authors.lastname: Kurita
authors.forename: Ayumi
authors.initials: A
authors.lastname: Harada
authors.forename: Mieko
authors.initials: M
authors.lastname: Matsumoto
authors.forename: Rieko
authors.initials: R
authors.lastname: Nakanishi
authors.forename: Tetsutaro
authors.initials: T
authors.lastname: Sugiura
mesh_terms: D000328:Adult; D000367:Age Factors; D015992:Body Mass Index; D015331:Cohort Studies; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000209:etiology* / Q000517:prevention & control; D008875:Middle Aged; D016272:Occupational Health; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012306:Risk; D013997:Time Factors