title: Diagnostic Value of p16 Methylation for Malignant Pleural Effusions: A Meta-analysis.
abstract: OBJECTIVE
  To evaluate the overall diagnostic performance of the p16 methylation for diagnosing malignant pleural effusion (MPE).
  
  
  METHODS
  All published literature in English and Chinese were reviewed. Sensitivity, specificity, likelihood ratio and diagnostic odds ratio (DOR) were pooled by using random-effects model or fixed-effects model. Summary receiver operating characteristic (SROC) curve was used to evaluate the overall diagnostic value.
  
  
  RESULTS
  Six studies were included with a total of 378 cases. The sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR) and DOR of p16 methylation in the diagnosis of MPE were 0.41 [95% confidence interval (CI) 0.35, 0.48], 0.97 [95% CI 0.93, 0.99], 9.57 [95% CI 4.53, 20.20], 0.61 [95% CI 0.45, 0.82] and 19.82 [95% CI 8.35, 47.04], respectively. The area under the curve (AUC) was 0.864.
  
  
  CONCLUSIONS
  Pleural p16 methylation test plays a useful role in the diagnosis of MPE.
authors.affiliation: Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Sichuan University, Chengdu 610041, PR China.
authors.forename: M
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Sichuan University, Chengdu 610041, PR China.
authors.forename: S-J
authors.initials: SJ
authors.lastname: Guo
authors.affiliation: Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Sichuan University, Chengdu 610041, PR China.
authors.forename: Y-C
authors.initials: YC
authors.lastname: Shen
authors.affiliation: Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Sichuan University, Chengdu 610041, PR China.
authors.forename: L-Q
authors.initials: LQ
authors.lastname: Jia
authors.affiliation: Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Sichuan University, Chengdu 610041, PR China.
authors.forename: D-D
authors.initials: DD
authors.lastname: Li
authors.affiliation: Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Sichuan University, Chengdu 610041, PR China.
authors.forename: C
authors.initials: C
authors.lastname: Wan
authors.affiliation: Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Sichuan University, Chengdu 610041, PR China. wenfuqiang@gmail.com.
authors.forename: F-Q
authors.initials: FQ
authors.lastname: Wen