title: Validation of noninvasive methods for detecting hepatic steatosis in patients with human immunodeficiency virus infection.
abstract: Nonalcoholic fatty liver disease (NAFLD) is common among patients with human immunodeficiency virus (HIV) infection; a reliable noninvasive method of detection is needed. We aimed to validate noninvasive means of identifying steatosis in HIV-positive patients. We performed a single-center retrospective study to validate the abilities of the liver fat score (LFS) and the lipid accumulation product (LAP) to detect hepatic steatosis in HIV-positive patients, compared with HIV-negative individuals (controls); NAFLD was confirmed by histology, and findings were compared with those from ultrasonography. These models then were validated in HIV-positive patients with NAFLD vs patients co-infected with HIV and hepatitis C virus (HCV) infection, without hepatic steatosis. LFS identified hepatic steatosis in HIV-positive subjects, compared with controls, with an area under the receiver operating curve value of 0.971 ± 0.027 (95% confidence interval, 0.91-1.000). At a cut-off value of -0.945, the LFS identified patients with steatosis with 100% sensitivity and 84% specificity. At a cut-off of value of -0.234, the LFS differentiated between HIV-positive subjects with NAFLD and patients co-infected with HIV and HCV with 100% sensitivity and 74% specificity. LAP scores ≥38 identified HIV-positive patients with steatosis with 89% sensitivity and 83% specificity. LAP scores ≥42 differentiated between HIV-positive subjects with steatosis and patients co-infected with HIV and HCV with 89% specificity and 70% sensitivity. We validated the accuracy of LFS and LAP in detecting hepatic steatosis in HIV-positive patients.
authors.affiliation: Department of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond, Virginia. Electronic address: mssiddiqui@mcvh-vcu.edu.
authors.forename: M Shadab
authors.initials: MS
authors.lastname: Siddiqui
authors.affiliation: Department of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond, Virginia.
authors.forename: Kavish R
authors.initials: KR
authors.lastname: Patidar
authors.affiliation: Department of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond, Virginia.
authors.forename: Sherry
authors.initials: S
authors.lastname: Boyett
authors.affiliation: Department of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond, Virginia.
authors.forename: Paula G
authors.initials: PG
authors.lastname: Smith
authors.affiliation: Department of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond, Virginia.
authors.forename: Arun J
authors.initials: AJ
authors.lastname: Sanyal
authors.affiliation: Department of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond, Virginia.
authors.forename: Richard K
authors.initials: RK
authors.lastname: Sterling
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005234:Fatty Liver / Q000175:diagnosis*; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D064237:Lipid Accumulation Product; D008099:Liver / Q000000981:diagnostic imaging* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014463:Ultrasonography
keywords: Diagnosis; Liver Disease; Prognostic Factor; Test