title: How to design a potent, specific, and stable angiotensin-converting enzyme inhibitor.
abstract: Angiotensin-converting enzyme inhibitors (ACE-Is) are a valuable class of antihypertensive drugs used in the treatment of cardiovascular system-related diseases. Hence, constant research into, and the development of, such compounds remain within the priorities of modern medical sciences. In this respect, a thorough understanding of their chemistry and biology is an important aspect of drug design; therefore, we present here available data on the pharmaceutical properties of ACE-Is. We also review the structural and biochemical features of the molecular target of ACE-Is and demonstrate several known enzyme-inhibitor complexes. Finally, we attempt to create a mathematical model describing the relation between the potency and/or stability of ACE-Is and their structural characteristics using quantitative structure-activity relation (QSAR), and quantitative structure-property relation (QSPR) techniques.
authors.affiliation: Poznan University of Medical Sciences, Chair and Department of Pharmaceutical Chemistry, 6th Grunwaldzka Street, 60-780 Poznan, Poland; Greater Poland Oncology Center, 15th Garbary Street, 61-866 Poznań, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Regulska
authors.affiliation: Poznan University of Medical Sciences, Chair and Department of Pharmaceutical Chemistry, 6th Grunwaldzka Street, 60-780 Poznan, Poland. Electronic address: bstanisz@ump.edu.pl.
authors.forename: Beata
authors.initials: B
authors.lastname: Stanisz
authors.affiliation: Poznan University of Medical Sciences, Chair and Department of Toxicology, 30th Dojazd Street, 60-631 Poznan, Poland.
authors.forename: Miłosz
authors.initials: M
authors.lastname: Regulski
authors.affiliation: Poznan University of Medical Sciences, Chair and Department of Toxicology, 30th Dojazd Street, 60-631 Poznan, Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Murias
mesh_terms: D000803:Angiotensin I / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D000804:Angiotensin II / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000959:Antihypertensive Agents / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D006801:Humans; D007703:Peptidyl-Dipeptidase A / Q000737:chemistry / Q000378:metabolism; D021281:Quantitative Structure-Activity Relationship
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D000804:Angiotensin II; D000803:Angiotensin I; D007703:Peptidyl-Dipeptidase A