title: The magnolia bioactive constituent 4-O-methylhonokiol protects against high-fat diet-induced obesity and systemic insulin resistance in mice.
abstract: Obesity is caused by a combination of both genetic and environmental risks. Disruption in energy balance is one of these risk factors. In the present study, the preventive effect on high-fat diet- (HFD-) induced obesity and insulin resistance in mice by Magnolia bioactive constituent 4-O-methylhonokiol (MH) was compared with Magnolia officinalis extract BL153. C57BL/6J mice were fed by normal diet or by HFD with gavage-administered vehicle, BL153, low-dose MH, and high-dose MH simultaneously for 24 weeks, respectively. Either MH or BL153 slightly inhibited body-weight gain of mice by HFD feeding although the food intake had no obvious difference. Body fat mass and the epididymal white adipose tissue weight were also mildly decreased by MH or BL153. Moreover, MH significantly lowered HFD-induced plasma triglyceride, cholesterol levels and activity of alanine transaminase (ALT), liver weight and hepatic triglyceride level, and ameliorated hepatic steatosis. BL153 only significantly reduced ALT and liver triglyceride level. Concurrently, low-dose MH improved HFD-induced hyperinsulinemia and insulin resistance. Furthermore, the infiltration of mast cells in adipose tissue was decreased in MH or in BL153 treatment. These results suggested that Magnolia bioactive constituent MH might exhibit potential benefits for HFD-induced obesity by improvement of lipid metabolism and insulin resistance.
authors.affiliation: Department of Cardiology & Radiation Oncology, First Hospital of Jilin University, Changchun 130021, China ; The Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou 325035, China ; Department of Pediatrics, Kosair Children Hospital Research Institute, University of Louisville, Louisville, KY 40202, USA.
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Pediatrics, Kosair Children Hospital Research Institute, University of Louisville, Louisville, KY 40202, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Cardiology & Radiation Oncology, First Hospital of Jilin University, Changchun 130021, China ; Department of Pediatrics, Kosair Children Hospital Research Institute, University of Louisville, Louisville, KY 40202, USA.
authors.forename: Xin
authors.initials: X
authors.lastname: Jiang
authors.affiliation: The Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou 325035, China ; College of Bioengineering, Chongqing University, Chongqing 400044, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: The Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou 325035, China ; Department of Pediatrics, Kosair Children Hospital Research Institute, University of Louisville, Louisville, KY 40202, USA.
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Yan
authors.affiliation: Department of Cardiology & Radiation Oncology, First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Diabetes and Obesity Center, University of Louisville, Louisville, KY 40202, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Conklin
authors.affiliation: Bioland Biotec Co., Ltd., Zhangjiang Modern Medical Device Park, Pudong, Shanghai 201201, China.
authors.forename: Ki-Soo
authors.initials: KS
authors.lastname: Kim
authors.affiliation: Bioland R&D Center, 59 Songjeong 2-gil, Byeongcheon, Dongnam, Cheonan, Chungnam 330-863, Republic of Korea.
authors.forename: Ki Ho
authors.initials: KH
authors.lastname: Kim
authors.affiliation: The Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou 325035, China ; Department of Pediatrics, Kosair Children Hospital Research Institute, University of Louisville, Louisville, KY 40202, USA.
authors.forename: Yi
authors.initials: Y
authors.lastname: Tan
authors.affiliation: Bioland R&D Center, 59 Songjeong 2-gil, Byeongcheon, Dongnam, Cheonan, Chungnam 330-863, Republic of Korea.
authors.forename: Young Heui
authors.initials: YH
authors.lastname: Kim
authors.affiliation: The Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou 325035, China ; Department of Pediatrics, Kosair Children Hospital Research Institute, University of Louisville, Louisville, KY 40202, USA.
authors.forename: Lu
authors.initials: L
authors.lastname: Cai
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects / Q000473:pathology; D050154:Adiposity / Q000187:drug effects; D000818:Animals; D001713:Biphenyl Compounds / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D059305:Diet, High-Fat; D005234:Fatty Liver / Q000097:blood / Q000188:drug therapy / Q000473:pathology; D005247:Feeding Behavior / Q000187:drug effects; D005951:Glucose Tolerance Test; D007249:Inflammation / Q000473:pathology; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D050356:Lipid Metabolism / Q000187:drug effects; D031566:Magnolia / Q000737:chemistry*; D008297:Male; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood
chemical_list: C542058:4-O-methylhonokiol; D001713:Biphenyl Compounds; D001786:Blood Glucose; D007328:Insulin; D017705:Lignans; D020011:Protective Agents; D014280:Triglycerides; D002784:Cholesterol