title: Albumin nanoparticles for the delivery of gabapentin: preparation, characterization and pharmacodynamic studies.
abstract: The study was aimed to prepare and evaluate gabapentin loaded albumin nanoparticles and to find out their effectiveness in treating epilepsy. Albumin nanoparticles of gabapentin were prepared by pH-coacervation method. The drug was administered into animals as free drug, gabapentin bound with nanoparticles, and gabapentin bound with nanoparticles coated with polysorbate 80. The polysorbate 80 coated nanoparticles increased the gabapentin concentration in the brain about 3 fold in comparison with the free drug. Moreover, the polysorbate 80 coated nanoparticles significantly reduced the duration of all phases of convulsion in both maximal electroshock induced and pentylenetetrazole induced convulsion models in comparison with free drug and drug bound with nanoparticle formulations, which indicates the ability of polysorbate 80 coated nanoparticles to enhance the gabapentin concentration in the brain.
authors.affiliation: Department of Pharmaceutics, Dayananda Sagar College of Pharmacy, Kumaraswamy Layout, Bangalore, Karnataka 560078, India. Electronic address: antrilparavai@gmail.com.
authors.forename: Barnabas
authors.initials: B
authors.lastname: Wilson
authors.affiliation: Department of Pharmaceutics, Dayananda Sagar College of Pharmacy, Kumaraswamy Layout, Bangalore, Karnataka 560078, India.
authors.forename: Y
authors.initials: Y
authors.lastname: Lavanya
authors.affiliation: Department of Pharmaceutics, Dayananda Sagar College of Pharmacy, Kumaraswamy Layout, Bangalore, Karnataka 560078, India.
authors.forename: S R B
authors.initials: SR
authors.lastname: Priyadarshini
authors.affiliation: Department of Bioengineering, School of Chemical & Biotechnology, SASTRA University, Thanjavur, Tamil Nadu 613401, India.
authors.forename: Muthu
authors.initials: M
authors.lastname: Ramasamy
authors.affiliation: Department of Pharmaceutics, Dayananda Sagar College of Pharmacy, Kumaraswamy Layout, Bangalore, Karnataka 560078, India.
authors.forename: Josephine Leno
authors.initials: JL
authors.lastname: Jenita
mesh_terms: D000588:Amines / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D001921:Brain / Q000378:metabolism; D003509:Cyclohexanecarboxylic Acids / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D004195:Disease Models, Animal; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D004339:Drug Compounding; D004597:Electroshock; D000077206:Gabapentin; D008297:Male; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry; D010433:Pentylenetetrazole; D011136:Polysorbates / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D017208:Rats, Wistar; D012640:Seizures / Q000188:drug therapy; D012710:Serum Albumin, Bovine / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D000588:Amines; D000927:Anticonvulsants; D003509:Cyclohexanecarboxylic Acids; D004337:Drug Carriers; D011136:Polysorbates; D012710:Serum Albumin, Bovine; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin; D010433:Pentylenetetrazole
keywords: Albumin nanoparticles; Brain drug targeting; Convulsion; Gabapentin