title: Metabolomic studies of human gastric cancer: review.
abstract: Metabolomics is a field of study in systems biology that involves the identification and quantification of metabolites present in a biological system. Analyzing metabolic differences between unperturbed and perturbed networks, such as cancerous and non-cancerous samples, can provide insight into underlying disease pathology, disease prognosis and diagnosis. Despite the large number of review articles concerning metabolomics and its application in cancer research, biomarker and drug discovery, these reviews do not focus on a specific type of cancer. Metabolomics may provide biomarkers useful for identification of early stage gastric cancer, potentially addressing an important clinical need. Here, we present a short review on metabolomics as a tool for biomarker discovery in human gastric cancer, with a primary focus on its use as a predictor of anticancer drug chemosensitivity, diagnosis, prognosis, and metastasis.
authors.affiliation: Naresh Doni Jayavelu, Nadav S Bar, Department of Chemical Engineering, Norwegian University of Science and Technology, N7491 Trondheim, Norway.
authors.forename: Naresh Doni
authors.initials: ND
authors.lastname: Jayavelu
authors.affiliation: Naresh Doni Jayavelu, Nadav S Bar, Department of Chemical Engineering, Norwegian University of Science and Technology, N7491 Trondheim, Norway.
authors.forename: Nadav S
authors.initials: NS
authors.lastname: Bar
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000378:metabolism*; D006801:Humans; D055432:Metabolomics / Q000379:methods; D011237:Predictive Value of Tests; D011379:Prognosis; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism*; D049490:Systems Biology
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor
keywords: Biomarkers; Chemosensitivity; Gastric cancer; Liquid/gas chromatography and mass spectrometry; Metabolomics; Metastasis; Nuclear magnetic resonance spectroscopy