title: The effect of vitamin C intake on the risk of hyperuricemia and serum uric acid level in Korean Multi-Rural Communities Cohort.
abstract: OBJECTIVE
  The aim of this study was to determine the association between vitamin C intake and risk of hyperuricemia or serum uric acid levels in male and female subjects in the Korean Multi-Rural Communities Prospective Cohort.
  
  
  METHODS
  This cross-sectional analysis was conducted in 9400 subjects enrolled in the Korean Multi-Rural Communities Cohort Study. The risk of hyperuricemia was assessed in five quintiles (Q1 to Q5) according to dietary and total vitamin C intake using multivariate-adjusted logistic regression models. Relationships between serum uric acid levels and vitamin C intake were evaluated using linear regression analysis after adjustment for covariates. Information about dietary components was collected using validated food frequency questionnaires.
  
  
  RESULTS
  Dietary vitamin C intake, but not total vitamin C intake, was significantly different between hyperuricemic and non-hyperuricemic subjects in males (P=0.01) and females (P=0.02). The risk of hyperuricemia decreased with increased dietary vitamin C intake in male and female subjects after multivariate adjustment (P for trend=0.002 in males and P for trend=0.02 in females). An effect of total vitamin C intake on hyperuricemia risk was identified in females (P for trend=0.04), but not males (P for trend=0.06). Serum uric acid level was linearly associated with total vitamin C intake in females (β=-0.0001, P=0.01), but not with dietary vitamin C intake in either gender.
  
  
  CONCLUSIONS
  This study showed that vitamin C intake might be in part responsible for hyperuricemia or serum uric acid level in the Korean Multi-Rural Communities Cohort.
authors.affiliation: Department of Preventive Medicine, Catholic University of Daegu School of Medicine, Daegu, Republic of Korea.
authors.forename: Jisuk
authors.initials: J
authors.lastname: Bae
authors.affiliation: Department of Preventive Medicine, School of Medicine Keimyung University, Daegu, Republic of Korea.
authors.forename: Dong Hoon
authors.initials: DH
authors.lastname: Shin
authors.affiliation: Department of Preventive Medicine, School of Medicine, Health Promotion Research Center, Kyungpook National University, Daegu, Republic of Korea.
authors.forename: Byung-Yeol
authors.initials: BY
authors.lastname: Chun
authors.affiliation: Department of Preventive Medicine, Hanyang University, College of Medicine, Seoul, Republic of Korea.
authors.forename: Bo Youl
authors.initials: BY
authors.lastname: Choi
authors.affiliation: Department of Preventive Medicine, Hanyang University, College of Medicine, Seoul, Republic of Korea.
authors.forename: Mi Kyung
authors.initials: MK
authors.lastname: Kim
authors.affiliation: Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
authors.forename: Min-Ho
authors.initials: MH
authors.lastname: Shin
authors.affiliation: Department of Preventive Medicine & Institute of Wonkwang Medical Science, Wonkwang University College of Medicine, Iksan, Jeonlabuk-do, Republic of Korea.
authors.forename: Young-Hoon
authors.initials: YH
authors.lastname: Lee
authors.affiliation: Department of Food and Nutrition, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, Republic of Korea. Electronic address: pspark@knu.ac.kr.
authors.forename: Pil Sook
authors.initials: PS
authors.lastname: Park
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Arthritis and Autoimmunity Research Center, Catholic University of Daegu School of Medicine, 3056-6 Daemyung 4-Dong, Namgu, Daegu 705-718, Republic of Korea. Electronic address: kimsk714@cu.ac.kr.
authors.forename: Seong-Kyu
authors.initials: SK
authors.lastname: Kim
mesh_terms: D000368:Aged; D001205:Ascorbic Acid / Q000097:blood / Q000494:pharmacology* / Q000502:physiology; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D033461:Hyperuricemia / Q000097:blood / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D056910:Republic of Korea; D012307:Risk Factors; D012424:Rural Population; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid; D001205:Ascorbic Acid
keywords: Hyperuricemia; Uric acid; Vitamin C