title: Genetic variants in C-reactive protein and ischemic stroke susceptibility.
abstract: Considerable discrepancies in the previously reported associations of the C-reactive protein (CRP) gene variants and ischemic stroke (IS) risk prompted us to perform this meta-analysis. We selected the fixed effects Mantel-Haenszel method to estimate the risk of IS [OR (odds ratio) along with its 95 % CI (confidence interval)] in relation to the CRP variants (-717 A > G, 1444 C > T). Heterogeneity test, influence analysis and publication bias test were appropriately performed using respective methods. We analyzed 1,926 IS patients and 2,678 controls and found the -717 A > G variant was not significantly associated with overall IS risk. Subsequent analysis of the 1444 C > T variant involving 3,278 samples similarly revealed no significant association with IS. There was no substantial heterogeneity or publication bias in this analysis. Our meta-analysis may provide first evidence showing that genetic variants within the CRP locus are unlikely to modulate risk of IS.
authors.affiliation: Department of Neurology, 309 Hospital of PLA, 17 Heishanhu Road, Haidian, Beijing, 100091, China, physiciancb@sina.com.
authors.forename: Bing
authors.initials: B
authors.lastname: Chen
authors.forename: Juan
authors.initials: J
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
mesh_terms: D002545:Brain Ischemia / Q000453:epidemiology* / Q000235:genetics*; D002097:C-Reactive Protein / Q000235:genetics*; D015984:Causality; D002681:China / Q000453:epidemiology; D015897:Comorbidity; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D006801:Humans; D038622:Internationality; D008297:Male; D009154:Mutation / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015995:Prevalence; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology* / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D002097:C-Reactive Protein