title: Mitochondrial replacement therapies can circumvent mtDNA-based disease transmission.
abstract: Mitochondrial DNA diseases are relatively common, sometimes devastating, and transmitted exclusively through the egg to children of carrier mothers. A study in Cell by Wang et al. (2014) adds the exciting possibility of a new therapy for preventing mitochondrial disease transmission predicated on the use of polar body genomes in mice.
authors.affiliation: Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, 3303 Southwest Bond Avenue, Portland, OR 97239, USA; Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, 505 Northwest 185(th) Avenue, Beaverton, OR 97006, USA.
authors.forename: Don P
authors.initials: DP
authors.lastname: Wolf
authors.affiliation: Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, 3303 Southwest Bond Avenue, Portland, OR 97239, USA; Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, 505 Northwest 185(th) Avenue, Beaverton, OR 97006, USA. Electronic address: mitalipo@ohsu.edu.
authors.forename: Shoukhrat
authors.initials: S
authors.lastname: Mitalipov
mesh_terms: D000818:Animals; D006801:Humans; D028361:Mitochondrial Diseases / Q000235:genetics* / Q000517:prevention & control*; D053652:Nuclear Transfer Techniques; D009865:Oocytes / Q000166:cytology*; D059705:Polar Bodies / Q000637:transplantation*