title: Salivary gland function after sialendoscopy for treatment of chronic radioiodine-induced sialadenitis.
abstract: BACKGROUND
  The purpose of this study was to determine whether sialendoscopy could ameliorate radioactive iodine-induced obstructive sialadenitis and restore the salivary gland dysfunction in recalcitrant radioactive iodine sialadenitis.
  
  
  METHODS
  Ten patients with 15 parotid glands of chronic radioactive iodine sialadenitis who did not respond to medical treatment were enrolled in this prospective study. We assessed subjective symptom scores and evaluated the objective salivary gland functions before and 3 months after sialendoscopy.
  
  
  RESULTS
  The post-sialendoscopic obstructive symptoms were significantly improved relative to pre-sialendoscopy (p = .009). Xerostomia-related symptom scores post-sialendoscopy did not differ significantly from the pre-sialendoscopy scores. Stimulated salivary flow rate post-sialendoscopy tended to increase relative to pre-sialendoscopy. No pre-sialendoscopic parameters associated with salivary uptake and secretion by salivary gland scintigraphy were significantly improved post-sialendoscopy.
  
  
  CONCLUSIONS
  These results show that sialendoscopy can improve obstructive symptoms; however, it seems to have some limitations for relief of xerostomia and improvement of salivary gland dysfunctions in recalcitrant chronic radioactive iodine sialadenitis.
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, Inha University School of Medicine, Incheon, Republic of Korea.
authors.forename: Young-Mo
authors.initials: YM
authors.lastname: Kim
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, Inha University School of Medicine, Incheon, Republic of Korea.
authors.forename: Jeong-Seok
authors.initials: JS
authors.lastname: Choi
authors.affiliation: Department of Internal Medicine, Inha University School of Medicine, Incheon, Republic of Korea.
authors.forename: Seong Bin
authors.initials: SB
authors.lastname: Hong
authors.affiliation: Department of Nuclear Medicine, Inha University School of Medicine, Incheon, Republic of Korea.
authors.forename: In Young
authors.initials: IY
authors.lastname: Hyun
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, Inha University School of Medicine, Incheon, Republic of Korea.
authors.forename: Jae-Yol
authors.initials: JY
authors.lastname: Lim
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects*; D008297:Male; D008405:Massage / Q000379:methods; D008875:Middle Aged; D018721:Muscarinic Agonists / Q000627:therapeutic use; D057605:Natural Orifice Endoscopic Surgery / Q000379:methods; D011446:Prospective Studies; D011878:Radiotherapy / Q000009:adverse effects*; D012469:Salivary Glands / Q000187:drug effects* / Q000378:metabolism; D012793:Sialadenitis / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D013964:Thyroid Neoplasms / Q000532:radiotherapy / Q000601:surgery; D013965:Thyroidectomy / Q000379:methods; D016896:Treatment Outcome
chemical_list: D007457:Iodine Radioisotopes; D018721:Muscarinic Agonists
keywords: radioiodine therapy; salivary gland dysfunction; sialadenitis; thyroid cancer; xerostomia