title: Diagnosis and treatment of Neospora caninum--associated dermatitis in a red fox (Vulpes vulpes) with concurrent Toxoplasma gondii infection.
abstract: A 3-mo-old red fox (Vulpes vulpes) developed generalized crusty plaques on its body during rehabilitation after an automobile accident requiring amputation of one leg. Histologic examination of skin lesion biopsy revealed granulomatous dermatitits with many intralesional protozoal tachyzoites. The protozoa stained positively with antibodies to Neospora caninum but not to Toxoplasma gondii. Treatment with clindamycin hydrochloride (10 mg/kg, twice daily, s.c.) for 1 mo completely resolved lesions, and protozoa were not demonstrable in biopsy of skin after treatment. The fox had agglutinating antibodies to T. gondii (modified agglutination test, titer 1:3200) and N. caninum (Neospora agglutination test, titer 1:25), and viable T. gondii (genotype III) was isolated from the skin biopsy after treatment. This is the first report of clinical neosporosis in a wild canid.
authors.forename: Jitender P
authors.initials: JP
authors.lastname: Duhey
authors.forename: Leah E
authors.initials: LE
authors.lastname: Whitesell
authors.forename: William E
authors.initials: WE
authors.lastname: Culp
authors.forename: Sharon
authors.initials: S
authors.lastname: Daye
mesh_terms: D000818:Animals; D002981:Clindamycin / Q000627:therapeutic use; D003048:Coccidiosis / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D003872:Dermatitis / Q000209:etiology / Q000662:veterinary*; D005589:Foxes; D008297:Male; D018688:Neospora; D011500:Protein Synthesis Inhibitors / Q000627:therapeutic use; D014122:Toxoplasma / Q000302:isolation & purification*; D014124:Toxoplasmosis, Animal / Q000150:complications*
chemical_list: D011500:Protein Synthesis Inhibitors; D002981:Clindamycin