title: Respiratory effects of fine and ultrafine particles from indoor sources--a randomized sham-controlled exposure study of healthy volunteers.
abstract: Particulate air pollution is linked to impaired respiratory health. We analyzed particle emissions from common indoor sources (candles burning (CB), toasting bread (TB), frying sausages (FS)) and lung function in 55 healthy volunteers (mean age 33.0 years) in a randomized cross-over controlled exposure study. Lung-deposited particle surface area concentration (PSC), size-specific particle number concentration (PNC) up to 10 µm, and particle mass concentration (PMC) of PM1, PM2.5 and PM10 were determined during exposure (2 h). FEV1, FVC and MEF25%-75% was measured before, 4 h and 24 h after exposure. Wilcoxon-rank sum tests (comparing exposure scenarios) and mixed linear regression using particle concentrations and adjusting for personal characteristics, travel time and transportation means before exposure sessions were performed. While no effect was seen comparing the exposure scenarios and in the unadjusted model, inverse associations were found for PMC from CB and FS in relation to FEV1 and MEF25%-75%. with a change in 10 µg/m3 in PM2.5 from CB being associated with a change in FEV1 of -19 mL (95%-confidence interval:-43; 5) after 4 h. PMC from TB and PNC of UFP were not associated with lung function changes, but PSC from CB was. Elevated indoor fine particles from certain sources may be associated with small decreases in lung function in healthy adults.
authors.affiliation: IUF-Leibniz Research Institute for Environmental Medicine, Auf'm Hennekamp 50, 40225 Düsseldorf, Germany. vanessa.soppa@IUF-Duesseldorf.de.
authors.forename: Vanessa J
authors.initials: VJ
authors.lastname: Soppa
authors.affiliation: IUF-Leibniz Research Institute for Environmental Medicine, Auf'm Hennekamp 50, 40225 Düsseldorf, Germany. roel.schins@uni-duesseldorf.de.
authors.forename: Roel P F
authors.initials: RP
authors.lastname: Schins
authors.affiliation: IUF-Leibniz Research Institute for Environmental Medicine, Auf'm Hennekamp 50, 40225 Düsseldorf, Germany. frauke.hennig@IUF-Duesseldorf.de.
authors.forename: Frauke
authors.initials: F
authors.lastname: Hennig
authors.affiliation: Air Quality and Sustainable Nanotechnology Unit, Institut für Energie- und Umwelttechnik (IUTA) e.V., Bliersheimer Straße 58-60, 47229 Duisburg, Germany. hellack@iuta.de.
authors.forename: Bryan
authors.initials: B
authors.lastname: Hellack
authors.affiliation: Air Quality and Sustainable Nanotechnology Unit, Institut für Energie- und Umwelttechnik (IUTA) e.V., Bliersheimer Straße 58-60, 47229 Duisburg, Germany. quass@iuta.de.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Quass
authors.affiliation: Air Quality and Sustainable Nanotechnology Unit, Institut für Energie- und Umwelttechnik (IUTA) e.V., Bliersheimer Straße 58-60, 47229 Duisburg, Germany. kaminski@iuta.de.
authors.forename: Heinz
authors.initials: H
authors.lastname: Kaminski
authors.affiliation: Air Quality and Sustainable Nanotechnology Unit, Institut für Energie- und Umwelttechnik (IUTA) e.V., Bliersheimer Straße 58-60, 47229 Duisburg, Germany. tky@iuta.de.
authors.forename: Thomas A J
authors.initials: TA
authors.lastname: Kuhlbusch
authors.affiliation: IUF-Leibniz Research Institute for Environmental Medicine, Auf'm Hennekamp 50, 40225 Düsseldorf, Germany. barbara.hoffmann@IUF-Duesseldorf.de.
authors.forename: Barbara
authors.initials: B
authors.lastname: Hoffmann
authors.affiliation: IUF-Leibniz Research Institute for Environmental Medicine, Auf'm Hennekamp 50, 40225 Düsseldorf, Germany. gudrun.weinmayr@IUF-Duesseldorf.de.
authors.forename: Gudrun
authors.initials: G
authors.lastname: Weinmayr
mesh_terms: D000293:Adolescent; D000328:Adult; D000393:Air Pollutants / Q000633:toxicity*; D016902:Air Pollution, Indoor / Q000009:adverse effects*; D018592:Cross-Over Studies; D005260:Female; D005541:Forced Expiratory Volume; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008448:Maximal Expiratory Flow Rate; D008875:Middle Aged; D010316:Particle Size; D052638:Particulate Matter / Q000633:toxicity*; D014797:Vital Capacity; D055815:Young Adult
chemical_list: D000393:Air Pollutants; D052638:Particulate Matter