title: Meta-analysis assessment of GP210 and SP100 for the diagnosis of primary biliary cirrhosis.
abstract: OBJECTIVE
  To conduct a systematic review of included studies assessing the association of GP210 and SP100 with the risk of primary biliary cirrhosis (PBC) using meta-analysis.
  
  
  METHODS
  Five databases, the Cochrane Library, MEDLINE, VIP, CNKI, WANFANG were used to detect the role of GP210 and SP100 in diagnosis of PBC. Approximately 13,000 participants from several countries were included in this analysis. Meta-DiSc statistical software was used for analysis.
  
  
  RESULTS
  25 studies on GP210 and 21 studies on SP100 were included in the meta-analysis. The DOR, sensitivity, specificity of GP210 in diagnosis of PBC were 24.854 (11.957-51.660), 0.272 (0.257-0.288), 0.985 (0.982-0.988), respectively, and they were 9.133 (4.739-17.600), 0.231 (0.213-0.249), 0.977 (0.973-0.981) for SP100.
  
  
  CONCLUSIONS
  Our meta-analysis indicated both GP210 and SP100 had high specificity but low sensitivity in diagnosis of PBC.
authors.affiliation: The Department of Laboratory Medicine, the Second Hospital Affiliated to Chongqing Medical University, Chongqing, China.
authors.forename: Shi-Ling
authors.initials: SL
authors.lastname: Hu
authors.affiliation: The Department of Gynecology and obstetrics, Youyang People's Hospital, Chongqing, China.
authors.forename: Feng-Rong
authors.initials: FR
authors.lastname: Zhao
authors.affiliation: The Department of Laboratory Medicine, the Second Hospital Affiliated to Chongqing Medical University, Chongqing, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Hu
authors.affiliation: The Department of Laboratory Medicine, the Second Hospital Affiliated to Chongqing Medical University, Chongqing, China.
authors.forename: Wei-Xian
authors.initials: WX
authors.lastname: Chen
mesh_terms: D000974:Antibodies, Antinuclear / Q000032:analysis / Q000276:immunology; D034961:Antigens, Nuclear / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology*; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000175:diagnosis* / Q000276:immunology; D028861:Nuclear Pore Complex Proteins / Q000276:immunology*
chemical_list: D000974:Antibodies, Antinuclear; D034961:Antigens, Nuclear; D001324:Autoantigens; D028861:Nuclear Pore Complex Proteins; C066642:SP100 protein, human