title: Effects of acupuncture on menopause-related symptoms and quality of life in women in natural menopause: a meta-analysis of randomized controlled trials.
abstract: OBJECTIVE
  This meta-analysis aims to evaluate the effects of acupuncture on hot flash frequency and severity, menopause-related symptoms, and quality of life in women in natural menopause.
  
  
  METHODS
  We systematically searched PubMed/Medline, PsychINFO, Web of Science, Cochrane Central Register of Controlled Trials, and CINAHL using keywords such as acupuncture, hot flash, menopause-related symptoms, and quality of life. Heterogeneity, moderator analysis, publication bias, and risk of bias associated with the included studies were examined.
  
  
  RESULTS
  Of 104 relevant studies, 12 studies with 869 participants met the inclusion criteria and were included in this study. We found that acupuncture significantly reduced the frequency (g = -0.35; 95% CI, -0.5 to -0.21) and severity (g = -0.44; 95% CI, -0.65 to -0.23) of hot flashes. Acupuncture significantly decreased the psychological, somatic, and urogenital subscale scores on the Menopause Rating Scale (g = -1.56, g = -1.39, and g = -0.82, respectively; P < 0.05). Acupuncture improved the vasomotor subscale score on the Menopause-Specific Quality of Life questionnaire (g= -0.46; 95% CI, -0.9 to -0.02). Long-term effects (up to 3 mo) on hot flash frequency and severity (g = -0.53 and g = -0.55, respectively) were found.
  
  
  CONCLUSIONS
  This meta-analysis confirms that acupuncture improves hot flash frequency and severity, menopause-related symptoms, and quality of life (in the vasomotor domain) in women experiencing natural menopause.
authors.affiliation: From the 1Graduate Institute of Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan; 2Department of Nursing, Fu Jen Catholic University, New Taipei City, Taiwan; 3School of Public Health, Taipei Medical University, Taipei, Taiwan; and 4Sleep Science Center, Taipei Medical University Hospital, Taipei, Taiwan.
authors.forename: Hsiao-Yean
authors.initials: HY
authors.lastname: Chiu
authors.forename: Chieh-Hsin
authors.initials: CH
authors.lastname: Pan
authors.forename: Yuh-Kae
authors.initials: YK
authors.lastname: Shyu
authors.forename: Bor-Cheng
authors.initials: BC
authors.lastname: Han
authors.forename: Pei-Shan
authors.initials: PS
authors.lastname: Tsai
mesh_terms: D015670:Acupuncture Therapy / Q000706:statistics & numerical data*; D005260:Female; D019584:Hot Flashes / Q000628:therapy*; D006801:Humans; D008593:Menopause / Q000502:physiology / Q000523:psychology*; D008875:Middle Aged; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic; D011795:Surveys and Questionnaires