title: Relationship between hepcidin levels and periodic limb movement disorder in patients with obstructive sleep apnea syndrome.
abstract: OBJECTIVE
  This study was aimed to assess potential correlations between periodic leg movement (PLM) index, hepcidin levels, and iron status in patients with obstructive sleep apnea syndrome (OSAS).
  
  
  METHODS
  Forty-four newly diagnosed OSAS patients and 49 non-apneic controls were enrolled in this study. All patients underwent polysomnographic evaluation. The hepcidin, iron, ferritin, total iron binding capacity, and C-reactive protein levels were measured.
  
  
  RESULTS
  The mean age was 47.4 ± 7.2 years (18-68) in the OSAS group and 44.9 ± 11.1 years (23-65) in the control group. There were no differences in age, gender, and smoking between OSAS patients and controls. Mean apnea-hypopnea index (AHI) was 25.1 events/h. Mean serum hepcidin levels were significantly higher in OSAS subjects (725.9 ng/ml) than in control subjects (646.0 ng/ml) (p < 0.001). Serum iron levels were significantly lower in the OSAS and PLM disorder groups than in control subjects (p < 0.001). Serum hepcidin levels were significantly correlated with AHI (r = 0.453) and PLM index (r = 0.114). Serum iron levels were significantly negatively correlated with AHI (r = -0.169) and PLM index (r = -0.180).
  
  
  CONCLUSIONS
  In our study, the level of hepcidin was increased in patients with OSAS. Our study indicates that levels of hepcidin correlate with the AHI and PLM index severity of OSAS.
authors.affiliation: Department of Chest Diseases, Medical Faculty, Dicle University, Diyarbakir, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Abakay
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Abakay
authors.forename: Yilmaz
authors.initials: Y
authors.lastname: Palanci
authors.forename: Hatice
authors.initials: H
authors.lastname: Yuksel
authors.forename: Hadice
authors.initials: H
authors.lastname: Selimoglu Sen
authors.forename: Osman
authors.initials: O
authors.lastname: Evliyaoglu
authors.forename: Abdullah Cetin
authors.initials: AC
authors.lastname: Tanrikulu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000175:diagnosis; D015536:Down-Regulation / Q000502:physiology; D005260:Female; D064451:Hepcidins / Q000097:blood*; D006801:Humans; D007501:Iron / Q000097:blood; D008297:Male; D008875:Middle Aged; D020189:Nocturnal Myoclonus Syndrome / Q000097:blood* / Q000175:diagnosis*; D017286:Polysomnography; D012016:Reference Values; D012148:Restless Legs Syndrome / Q000097:blood / Q000175:diagnosis; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000175:diagnosis*; D012894:Sleep Stages / Q000502:physiology; D013223:Statistics as Topic; D055815:Young Adult
chemical_list: D064451:Hepcidins; D007501:Iron