title: Correlation between brain cortex metabolic and perfusion functions in subjective idiopathic tinnitus.
abstract: OBJECTIVE
  Subjective tinnitus has associated with abnormal brain metabolism and perfusion found in functional imaging studies by fluorodeoxyglucose (FDG) and technetium99m (TC99m). But there is no study evaluating the association of brain metabolism and perfusion abnormalities in a group of these subjects. The aim of this study was to investigate if there is any significant correlation between the brain perfusion and metabolism abnormalities in subjects with tinnitus.
  
  
  METHODS
  In this cross-sectional study, 52 patients were undergone TC99m-ECD single photon emission computerized tomography (SPECT) scan and F18-FDG positron emission tomography (PET). The results of PET and SPECT scanning were fused with MRI to accurate anatomical localization of abnormalities. The analysis was performed using Kendal's correlation, t-test and chi square.
  
  
  RESULTS
  Assessing these 52 tinnitus subjects (containing 42 males [76.4%]) showed that a significant correlation was found between the brain metabolic function and perfusion (p value 0.001).
authors.affiliation: Laboratory for Auditory Neuroscience, ENT and Head & Neck Center, Iran University of Medical Sciences, Tehran, Iran.smahmoudian@tums.ac.ir
authors.forename: Saeid
authors.initials: S
authors.lastname: Mahmoudian
authors.forename: Mohammad
authors.initials: M
authors.lastname: Farhadi
authors.forename: Saeid
authors.initials: S
authors.lastname: Gholami
authors.forename: Fariba
authors.initials: F
authors.lastname: Saddadi
authors.forename: Maryam
authors.initials: M
authors.lastname: Jalesi
authors.forename: Ali Reza
authors.initials: AR
authors.lastname: Karimian
authors.forename: Maryam
authors.initials: M
authors.lastname: Darbeheshti
authors.forename: Sara
authors.initials: S
authors.lastname: Momtaz
authors.forename: Sara
authors.initials: S
authors.lastname: Fardin
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D002540:Cerebral Cortex / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D004292:Dominance, Cerebral / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D006801:Humans; D007089:Image Enhancement; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D012039:Regional Blood Flow / Q000502:physiology*; D013223:Statistics as Topic; D014012:Tinnitus / Q000000981:diagnostic imaging / Q000503:physiopathology*; D015899:Tomography, Emission-Computed, Single-Photon