title: Palladium-catalyzed oxidative C-N bond coupling involving a solvent-controlled regioselective bromination process.
abstract: Stereoselective palladium-catalyzed oxidative C-N bond coupling reactions between aromatic amines and alkenes involving a solvent-controlled regioselective bromination process under 1 atm of oxygen atmosphere are disclosed, providing easy access to two different brominated enamines. The addition of hydrogen peroxide (30% aq) as a co-oxidant in the system is crucial for the dehydrogenative aminohalogenation under molecular oxygen (1 atm), and in such a case, the C-N bond coupling/electrophilic bromination reaction cascade is proposed. Furthermore, the different reaction media leads to a switched regioselectivity of the process.
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou 510640, China.
authors.forename: Xiaochen
authors.initials: X
authors.lastname: Ji
authors.forename: Huawen
authors.initials: H
authors.lastname: Huang
authors.forename: Wenfang
authors.initials: W
authors.lastname: Xiong
authors.forename: Kunbo
authors.initials: K
authors.lastname: Huang
authors.forename: Wanqing
authors.initials: W
authors.lastname: Wu
authors.forename: Huanfeng
authors.initials: H
authors.lastname: Jiang