title: Lenticular changes in congenital iridolenticular choroidal coloboma.
abstract: OBJECTIVE
  To evaluate the lenticular changes associated with congenital iridolenticular choroidal coloboma.
  
  
  METHODS
  Retrospective, observational case series.
  
  
  METHODS
  setting: Tertiary eye care center in south India. study population: Total of 145 eyes of 98 patients. observation procedure: Medical records of all patients with the diagnosis of congenital iridolenticular choroidal coloboma between January 2011 and December 2012 were reviewed retrospectively for demographic profile, extent of coloboma, and associated lenticular changes.
  
  
  RESULTS
  Median age of patients at the time of initial visit was 23 years (interquartile range, 13-38 years). The male-to-female ratio was ∼ 1:1. Forty-eight percent had bilateral involvement. Lens showed cataract changes in 68 eyes (48.9%). The most common type of cataract was nuclear sclerosis, which was noted in 51% of cases. A distinct type of cataract, called "coloboma cataract" (characterized by linear opacity in the region of the coloboma), was observed in 29% of cases. Other associated findings were phacodonesis in 3 eyes, dislocation in 3 eyes, and subluxation in 5 eyes. Disc and/or macular involvement in 57 eyes (39.3%) did not influence the type or density of cataract (P > .05).
  
  
  CONCLUSIONS
  Congenital iridolenticular choroidal coloboma is associated with early cataractous changes. The most common type of cataract is nuclear sclerosis. The type and density of cataract do not seem to be related to the extent of the choroidal coloboma. We suggest a distinct description with the nomenclature "coloboma cataract" to be considered in the clinical grading of cataracts in patients with this condition.
authors.affiliation: Prof. Brien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, India.
authors.forename: Ashik
authors.initials: A
authors.lastname: Mohamed
authors.affiliation: Cornea and Anterior Segment Services, L V Prasad Eye Institute, Hyderabad, India. Electronic address: sunita@lvpei.org.
authors.forename: Sunita
authors.initials: S
authors.lastname: Chaurasia
authors.affiliation: Cornea and Anterior Segment Services, L V Prasad Eye Institute, Hyderabad, India.
authors.forename: Muralidhar
authors.initials: M
authors.lastname: Ramappa
authors.affiliation: Cornea and Anterior Segment Services, L V Prasad Eye Institute, Hyderabad, India.
authors.forename: Virender S
authors.initials: VS
authors.lastname: Sangwan
authors.affiliation: Srimati Kanuri Santhamma Centre for Vitreo Retinal Diseases, L V Prasad Eye Institute, Hyderabad, India.
authors.forename: Subhadra
authors.initials: S
authors.lastname: Jalali
mesh_terms: D000293:Adolescent; D000328:Adult; D002386:Cataract / Q000175:diagnosis* / Q000628:therapy; D002387:Cataract Extraction; D002829:Choroid / Q000002:abnormalities*; D003103:Coloboma / Q000175:diagnosis* / Q000601:surgery; D005260:Female; D006801:Humans; D007498:Iris / Q000002:abnormalities*; D007908:Lens, Crystalline / Q000002:abnormalities* / Q000473:pathology*; D008297:Male; D012163:Retinal Detachment / Q000175:diagnosis / Q000601:surgery; D012189:Retrospective Studies; D014821:Vitrectomy; D055815:Young Adult