title: Endoscopic treatment of vesicoureteral reflux with polyacrylate polyalcohol copolymer and dextranomer/hyaluronic acid in adults.
abstract: OBJECTIVE
  Aim of this study is to examine the effectiveness of dextranomer/hyaluronic acid copolymer and polyacrylate polyalcohol copolymer in endoscopic treatment of vesicoureteral reflux disease in adult patients with and without chronic renal failure.
  
  
  METHODS
  Thirty two patients (12 female, 20 male) with a total of 50 renal units were treated for vesicoureteral reflux. There were 26 (81%) chronic renal failure patients. The success of treatment was evaluated by voiding cystouretrography at 3rd and 12th months after subureteric injection. The persistence of reflux was considered as failure. Patients were divided into two groups according to injected material. Age, sex, grade of reflux and treatment results were recorded and evaluated.
  
  
  RESULTS
  Reflux was scored as grade 1 in seven (14%), grade 2 in 16 (32%), grade 3 in 21 (42%) and grade 4 in six (12%) renal units. There was not patient with grade 5 reflux. Fourteen renal units (28%) were treated with dextranomer/hyaluronic acid copolymer (group 1) and 36 renal units (72%) were treated with polyacrylate polyalcohol copolymer (group 2). The overall treatment success was achieved at 40 renal units (80%). The treatment was successful at 11 renal units (79%) in group 1 and 29 renal units (81%) in group 2 (p = 0.71). There was not statistically significant difference between two groups with patients with chronic renal failure in terms of treatment success (p = 1.00).
  
  
  CONCLUSIONS
  The effectiveness of two bulking agents was similar in treatment of vesicoureteral reflux disease in adult patients and patients with chronic renal failure.
authors.affiliation: Urology Clinic, Aksehir Public Hospital, Konya, Turkey.
authors.forename: Akif
authors.initials: A
authors.lastname: Turk
authors.affiliation: Urology Clinic, Biga Public Hospital, Canakkale, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Selimoglu
authors.affiliation: Urology Clinic, Sinop Atatürk Public Hospital, Sinop, Turkey.
authors.forename: Kadir
authors.initials: K
authors.lastname: Demir
authors.affiliation: Urology Clinic, Fatsa Public Hospital, Ordu, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Celik
authors.affiliation: Urology Clinic, Kartal Training Hospital, Istanbul, Turkey.
authors.forename: Erkin
authors.initials: E
authors.lastname: Saglam
authors.affiliation: Urology Clinic, Kartal Training Hospital, Istanbul, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Tarhan
mesh_terms: D000180:Acrylic Resins / Q000627:therapeutic use*; D000328:Adult; D001672:Biocompatible Materials / Q000627:therapeutic use; D003911:Dextrans / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D007267:Injections / Q000379:methods; D007676:Kidney Failure, Chronic / Q000503:physiopathology; D008297:Male; D015203:Reproducibility of Results; D013997:Time Factors; D016896:Treatment Outcome; D018666:Ureteroscopy / Q000379:methods*; D014718:Vesico-Ureteral Reflux / Q000503:physiopathology / Q000601:surgery*
chemical_list: D000180:Acrylic Resins; D001672:Biocompatible Materials; D003911:Dextrans; C487487:dextranomer-hyaluronic acid copolymer; D006820:Hyaluronic Acid