title: [Ischemic stroke--diagnosis and treatment].
abstract: Management of ischemic stroke is targeted on four therapeutic objectives: limitation of neurological deficit, prevention of earyl stroke recurrence, protection against complications, and secondary prevention. Intravenous thrombolysis within 4.5h of stroke onset is the only proven therapy to improvefunctional outcome. Although promising, neither endovascular recanalisation nor neuroprotective strategies have demonstrated efficacy so far. Immediate administration of antiplatelet agents like acetylsalicylic acid and clopidogrel - in case of intravenous thrombolysis at the earliest after 24h - is effective to prevent early stroke recurrence, whereas anticoagulants should be ommitted in this stage because of an increased risk of cerebral hemorrhage. Subcutaneous heparin/low molecular weight heparin, mobilisation, nasogastric tube, and decompressive craniectomy may protect from venous thromboembolism, aspiration pneumonia, and malignant brain edema, respectively. Secondary prevention is guided by stroke etiology, e.g. oral anticoagulation in the presence atrial fibrillation or endarterectomy in case of sympomatic high-grade carotid stenosis.
authors.forename: Michael
authors.initials: M
authors.lastname: Görtler
authors.forename: Andreas
authors.initials: A
authors.lastname: Oldag
authors.forename: Andrea
authors.initials: A
authors.lastname: Brejova
mesh_terms: D002545:Brain Ischemia / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D061185:Mechanical Thrombolysis / Q000009:adverse effects / Q000379:methods; D020521:Stroke / Q000175:diagnosis / Q000628:therapy*; D015912:Thrombolytic Therapy / Q000009:adverse effects / Q000379:methods*