title: Point-of-care platforms.
abstract: Point-of-care applications are gaining increasing interest in clinical diagnostics and emergency applications. Biosensors are used to monitor the biomolecular interaction process between a disease biomarker and a recognition element such as a reagent. Essential are the quality and selectivity of the recognition elements and assay types used to improve sensitivity and to avoid nonspecific interactions. In addition, quality measures are influenced by the detection principle and the evaluation strategies. For these reasons, this review provides a survey and validation of recognition elements, assays, and various types of detection methods for point-of-care testing (POCT) platforms. Common applications of clinical parameters are discussed and considered. In this ever-changing field, a snapshot of current applications is needed. We provide such a snapshot by way of a table including literature citations and also discuss these applications in more detail throughout.
authors.affiliation: Institute of Physical and Theoretical Chemistry, University of Tuebingen, D-72076 Tuebingen, Germany; email: guenter.gauglitz@ipc.uni-tuebingen.de.
authors.forename: Günter
authors.initials: G
authors.lastname: Gauglitz
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D003955:Diagnostic Tests, Routine / Q000379:methods*; D006801:Humans; D019095:Point-of-Care Systems; D000067716:Point-of-Care Testing
keywords: applications; assays; biomarkers; biosensors; recognition elements; transduction elements