title: Perinatal exposure to solvents and wheezing, eczema and food allergies at age 2.
abstract: OBJECTIVE
  The time from the prenatal period through early childhood is an important window of vulnerability for the developing immune and respiratory systems, both sensitive to environmental chemicals such as solvents. This study sought to examine the effects of solvent exposure during the prenatal and postnatal periods on wheezing, eczema and food allergies in early childhood.
  
  
  METHODS
  This study, based on the PELAGIE cohort, included 1505 mother-child pairs with measurements of prenatal and postnatal solvent exposures and data on wheezing, eczema or food allergies. The maternal occupation reported at inclusion, in early pregnancy allowed us to define prenatal occupational solvent exposure (by three specific job-exposure matrices). Data on prenatal and postnatal domestic solvent exposure, that is exposure to products that contain solvents, were obtained from self-administered questionnaires, once at inclusion and again when the child was 2 years old. Outcome data was collected at the 2-year follow-up. Associations between exposures and outcomes were estimated by logistic regression models, after adjustment for potential confounders.
  
  
  RESULTS
  No association was observed between prenatal exposure to solvents and the outcomes studied. Postnatal exposure was associated with an increased risk of wheezing (OR=1.80 (95% CI 1.25 to 2.59)) which persisted after adjustment for prenatal exposure. No significant association was observed with eczema or food allergies.
  
  
  CONCLUSIONS
  Postnatal exposure to solvent-containing products in the home may increase the risk of wheezing in early childhood. Follow-up studies are needed to determine if the health effects observed at age 2 persist at later ages.
authors.affiliation: Inserm (Institut National de la Santé et de la Recherche Médicale) UMR 1085, IRSET (Institut de Recherche Santé Environnement & Travail), Université de Rennes 1, Rennes Cedex, France.
authors.forename: Emma
authors.initials: E
authors.lastname: Bajeux
authors.affiliation: Inserm (Institut National de la Santé et de la Recherche Médicale) UMR 1085, IRSET (Institut de Recherche Santé Environnement & Travail), Université de Rennes 1, Rennes Cedex, France.
authors.forename: Sylvaine
authors.initials: S
authors.lastname: Cordier
authors.affiliation: Inserm (Institut National de la Santé et de la Recherche Médicale) UMR 1085, IRSET (Institut de Recherche Santé Environnement & Travail), Université de Rennes 1, Rennes Cedex, France Département Santé Environnement Travail et Génie Sanitaire (DSET&GS), Ecole des Hautes Etudes en Santé Publique (EHESP), Rennes, France.
authors.forename: Ronan
authors.initials: R
authors.lastname: Garlantézec
authors.affiliation: Inserm (Institut National de la Santé et de la Recherche Médicale) UMR 1085, IRSET (Institut de Recherche Santé Environnement & Travail), Université de Rennes 1, Rennes Cedex, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Monfort
authors.affiliation: Inserm (Institut National de la Santé et de la Recherche Médicale) UMR 1085, IRSET (Institut de Recherche Santé Environnement & Travail), Université de Rennes 1, Rennes Cedex, France Département de Pédiatrie, Centre Hospitalier Universitaire de Rennes (CHU), Rennes, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Rouget
authors.affiliation: Inserm (Institut National de la Santé et de la Recherche Médicale) UMR 1085, IRSET (Institut de Recherche Santé Environnement & Travail), Université de Rennes 1, Rennes Cedex, France Service d'Epidémiologie et de Santé Publique, Centre Hospitalier Universitaire de Rennes (CHU), Rennes, France.
authors.forename: Fabienne
authors.initials: F
authors.lastname: Pelé
mesh_terms: D000328:Adult; D002675:Child, Preschool; D015331:Cohort Studies; D004485:Eczema / Q000209:etiology*; D004781:Environmental Exposure / Q000032:analysis; D005260:Female; D005512:Food Hypersensitivity / Q000209:etiology*; D006795:Household Products / Q000633:toxicity; D006801:Humans; D016015:Logistic Models; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000209:etiology*; D012120:Respiration Disorders / Q000209:etiology*; D012135:Respiratory Sounds; D012997:Solvents / Q000633:toxicity*
chemical_list: D012997:Solvents
keywords: Children; Postnatal Exposure; Prenatal Exposure; Solvents; Wheezing