title: Electroencephalographic abnormalities and 5-year outcome in first-episode psychosis.
abstract: OBJECTIVE
  To examine the relation of electroencephalographic abnormalities to 5-year outcomes in first-episode psychosis (FEP).
  
  
  METHODS
  Patients (n = 103) had their baseline electroencephalogram (EEG) classified by modified Mayo Clinic criteria. Symptoms and psychosocial functioning were rated after 5 years of treatment.
  
  
  RESULTS
  Dysrhythmic EEG was associated with persistence in positive and negative symptoms of psychoses and poorer psychosocial functioning at 5-year follow-up, independently of other characteristics, such as duration of untreated illness or premorbid adjustment. A higher percentage of people with comorbid substance use disorder had normal EEG.
  
  
  CONCLUSIONS
  Abnormal baseline EEG in FEP is associated with poorer 5-year symptomatic and functional outcome.
authors.affiliation: Director-Prevention and Early Intervention Program for Psychoses (PEPP), London Health Sciences Centre-Victoria Hospital, London, Ontario; Professor of Psychiatry, The University of Western Ontario, London, Ontario.
authors.forename: Rahul
authors.initials: R
authors.lastname: Manchanda
authors.affiliation: Professor, Departments of Psychiatry, and Epidemiology and Biostatistics, The University of Western Ontario, London, Ontario; Research Psychologist- PEPP, London Health Sciences Centre, London, Ontario.
authors.forename: Ross
authors.initials: R
authors.lastname: Norman
authors.affiliation: Director-PEPP Montréal, Douglas Institute, Montréal, Quebec; Professor and Canada Research Chair in Early Psychosis, Department of Psychiatry, McGill University, Montreal, Quebec.
authors.forename: Ashok
authors.initials: A
authors.lastname: Malla
authors.affiliation: Associate Professor, Department of Psychiatry, The University of Western Ontario, London, Ontario; Consultant-PEPP, London Health Sciences Centre, London, Ontario.
authors.forename: Rajendra
authors.initials: R
authors.lastname: Harricharan
authors.affiliation: Associate Professor, Department of Psychiatry, The University of Western Ontario, London, Ontario; Consultant-PEPP, Department of Psychiatry, London Health Sciences Centre, London, Ontario.
authors.forename: Sandra
authors.initials: S
authors.lastname: Northcott
authors.affiliation: Assistant Professor, Department of Psychiatry, The University of Western Ontario, London, Ontario; Consultant-PEPP, Department of Psychiatry, London Health Sciences Centre, London, Ontario.
authors.forename: Julie
authors.initials: J
authors.lastname: Richard
mesh_terms: D000223:Adaptation, Psychological; D000293:Adolescent; D000328:Adult; D002648:Child; D015897:Comorbidity; D004522:Educational Status; D004569:Electroencephalography / Q000379:methods / Q000706:statistics & numerical data; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009864:Ontario / Q000453:epidemiology; D063868:Patient Outcome Assessment; D011237:Predictive Value of Tests; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D012917:Social Adjustment; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology