title: [Ecological function and application of toxin beta-ODAP in grass pea (Lathyrus sativus)].
abstract: Grass pea (Lathyrus sativus) is a legume with various adverse adaptability and rich nutrition. However, it can lead to the human and animal neurotoxicity after long-term consumption due to its neurotoxin, beta-N-oxalyl-L-alpha, beta-diaminopropionic acid (beta-ODAP), limiting its utilization. This paper summarized the influences of beta-ODAP on osmotic adjustment and growth regulation in grass pea under drought stress, the research progress in analysis methods, toxicological mechanisms and practical utility of beta-ODAP, and the breeding strategies for low- and zero-beta-ODAP. Beta-ODAP synthesis was found to be abundant in grass pea under drought stress and its content was enhanced gradually with the increasing extent of drought stress. beta-ODAP could supply nitrogen for plant growth and seed development, scavenge reactive oxygen species (ROS), involve in osmotic adjustment as a soluble amino acid, transport zinc-ions as a carrier molecule, and impact nodule development. However, increasing the content of sulfur-containing amino acids (methionine and cysteine) could decrease the level of toxicity of grass pea. There were a lot of investigations on collecting genetic resources, cross breeding, tissue culture, and gene manipulation for low- and zero-toxin in grass pea in recent years. Although beta-ODAP could induce excitotoxicity by damaging intracellular Ca2+ homeostasis and as glutamate analogues, it has medicinal value on hemostasis and anti-tumor.
authors.forename: Jun-Lan
authors.initials: JL
authors.lastname: Xiong
authors.forename: Xue
authors.initials: X
authors.lastname: Bai
authors.forename: Asfa
authors.initials: A
authors.lastname: Batool
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Kong
authors.forename: Rui-Yue
authors.initials: RY
authors.lastname: Tan
authors.forename: Ya-Fu
authors.initials: YF
authors.lastname: Wang
authors.forename: Zhi-Xiao
authors.initials: ZX
authors.lastname: Li
authors.forename: You-Cai
authors.initials: YC
authors.lastname: Xiong
mesh_terms: D000596:Amino Acids; D000599:Amino Acids, Diamino / Q000737:chemistry*; D055864:Droughts; D027807:Lathyrus / Q000737:chemistry*; D009498:Neurotoxins / Q000737:chemistry*; D017382:Reactive Oxygen Species
chemical_list: D000596:Amino Acids; D000599:Amino Acids, Diamino; D009498:Neurotoxins; D017382:Reactive Oxygen Species; C100126:oxalyldiaminopropionic acid