title: Role of oxidative stress in Deoxynivalenol induced toxicity.
abstract: Deoxynivalenol (DON) is a Fusarium toxin that causes a variety of toxic effects with symptoms such as diarrhoea and low weight gain. To date, no review has addressed the toxicity of DON in relation to oxidative stress. The focus of this article is primarily intended to summarize the information associated with oxidative stress as a plausible mechanism for DON-induced toxicity. The present review shows that over the past two decades, several investigators have documented the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in oxidative stress as a result of DON treatment and have correlated them with various types of toxicity. The evidence for induction of an oxidative stress response resulting from DON exposure has been more focused on in vitro models and is relatively lacking in in vivo studies. Hence, more emphasis should be laid on in vivo investigations with doses that are commonly encountered in food products. Since DON is commonly found in food and feed, the cellular effects of this toxin in relation to oxidative stress, as well as effective measures to combat its toxicity, are important aspects to be considered for future studies.
authors.affiliation: Food, Drug and Chemical Toxicology, CSIR-Indian Institute of Toxicology Research, P.O. Box No. 80, Mahatma Gandhi Marg, Lucknow 226 001, India; Department of Biochemistry, Banaras Hindu University (BHU), Varanasi, India.
authors.forename: Sakshi
authors.initials: S
authors.lastname: Mishra
authors.affiliation: Food, Drug and Chemical Toxicology, CSIR-Indian Institute of Toxicology Research, P.O. Box No. 80, Mahatma Gandhi Marg, Lucknow 226 001, India.
authors.forename: Premendra D
authors.initials: PD
authors.lastname: Dwivedi
authors.affiliation: Department of Biochemistry, Banaras Hindu University (BHU), Varanasi, India.
authors.forename: Haushila P
authors.initials: HP
authors.lastname: Pandey
authors.affiliation: Food, Drug and Chemical Toxicology, CSIR-Indian Institute of Toxicology Research, P.O. Box No. 80, Mahatma Gandhi Marg, Lucknow 226 001, India. Electronic address: mditrc@rediffmail.com.
authors.forename: Mukul
authors.initials: M
authors.lastname: Das
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D004249:DNA Damage / Q000187:drug effects; D005670:Fusarium / Q000737:chemistry; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects; D023421:Models, Animal; D018384:Oxidative Stress / Q000187:drug effects*; D026361:Reactive Nitrogen Species / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D014255:Trichothecenes / Q000633:toxicity*
chemical_list: D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D014255:Trichothecenes; C007262:deoxynivalenol
keywords: Antioxidants; DNA damage; Deoxynivalenol; Lipid peroxidation; Oxidative stress; Reactive oxygen species