title: In vitro antibacterial activity of meclofenamate metal complexes with Cd(II), Pb(II), Co(II), and Cu(II). Crystal structures of [Cd(C14H10NO2Cl2)2∙(CH3OH)]n and [Cu(C14H10NO2Cl2)2(C5H5N)2].
abstract: The synthesis and characterization of five metal complexes derived from sodium meclofenamate (1) are reported: [Cd(C14H10NO2Cl2)2∙(CH3OH)]n∙nCH3OH (6), [Pb(C14H10NO2Cl2)2]n (7), [Co(C14H10NO2Cl2)]n (8), [Cu(C14H10NO2Cl2)]n (9), and [Cu(C14H10NO2Cl2)2(C5H5N)2] (10) (C14H10NO2Cl2=meclofenamate; C5H5N=pyridine). The characterization of the compounds was based on FTIR and UV-visible spectroscopy, mass spectrometry and, in the case of complexes 6 and 10, single crystal X-ray diffraction analysis. For compound 6, the structural analysis revealed a 1-D polymeric chain structure, in which pentagonal planar [Cd(RCOO)2(CH3OH)] units were linked through bridging carboxylate functions of the meclofenamate ligands. The overall coordination environment of the Cd(II) ions was seven-coordinate, since each carboxylate group exhibited a μ3-bridging coordination mode. On the other hand, for complex 10 a discrete mononuclear structure was observed, in which the six-coordinate copper(II) metal atoms were coordinated by two pyridine molecules and the carboxylate functions of two meclofenamate entities, in an anisobidentate coordination mode. The antibacterial activity of compounds 6-9 against four strains of Gram positive (Staphylococcus aureus and Bacillus subtilis) and Gram negative (Escherichia coli and Pseudomonas aeruginosa) bacteria was examined, finding that only complex 6 was active. Additionally, it was found that the Co(II) and Cu(II) complexes 8 and 9 showed peroxidase activity.
authors.affiliation: Departamento de Ciencias Químico-Biológicas, Universidad de las Américas-Puebla, Ex-Hacienda Sta. Catarina Mártir, Cholula, 72820 Puebla, Puebla, Mexico; Departamento de Ciencias Biológicas, Universidad Popular Autónoma del Estado de Puebla, Col. Santiago, 72000 Puebla, Puebla, Mexico.
authors.forename: T
authors.initials: T
authors.lastname: Palacios-Hernández
authors.affiliation: Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Col. Chamilpa, 62209 Cuernavaca, Morelos, Mexico.
authors.forename: H
authors.initials: H
authors.lastname: Höpfl
authors.affiliation: Departamento de Ciencias Químico-Biológicas, Universidad de las Américas-Puebla, Ex-Hacienda Sta. Catarina Mártir, Cholula, 72820 Puebla, Puebla, Mexico.
authors.forename: J L
authors.initials: JL
authors.lastname: Sánchez-Salas
authors.affiliation: Centro de Química, ICUAP, Benemérita Universidad Autónoma de Puebla, AP 1613, 72000 Puebla, Puebla, Mexico.
authors.forename: E
authors.initials: E
authors.lastname: González-Vergara
authors.affiliation: Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, AP 1613, 72000 Puebla, Puebla, Mexico.
authors.forename: A
authors.initials: A
authors.lastname: Pérez-Benítez
authors.affiliation: Departamento de Ciencias Químico-Biológicas, Universidad de las Américas-Puebla, Ex-Hacienda Sta. Catarina Mártir, Cholula, 72820 Puebla, Puebla, Mexico.
authors.forename: M A
authors.initials: MA
authors.lastname: Quiroz-Alfaro
authors.affiliation: Departamento de Ciencias Químico-Biológicas, Universidad de las Américas-Puebla, Ex-Hacienda Sta. Catarina Mártir, Cholula, 72820 Puebla, Puebla, Mexico. Electronic address: miguela.mendez@udlap.mx.
authors.forename: M A
authors.initials: MA
authors.lastname: Méndez-Rojas
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D002104:Cadmium / Q000737:chemistry; D003035:Cobalt / Q000737:chemistry; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology; D003300:Copper / Q000737:chemistry; D018360:Crystallography, X-Ray; D004926:Escherichia coli / Q000187:drug effects; D006860:Hydrogen Bonding; D006861:Hydrogen Peroxide / Q000737:chemistry; D007854:Lead / Q000737:chemistry; D008469:Meclofenamic Acid / Q000031:analogs & derivatives* / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D008968:Molecular Conformation; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D056831:Coordination Complexes; D002104:Cadmium; D007854:Lead; D003035:Cobalt; D008469:Meclofenamic Acid; D003300:Copper; D006861:Hydrogen Peroxide
keywords: Antibacterial activity; Cadmium; Complex; Lead; Meclofenamic; Peroxidase activity