title: Homochiral metal-organic frameworks and their application in chromatography enantioseparations.
abstract: The last frontier in the chiral stationary phases (CSPs) field for chromatography enantioseparations is represented by homochiral metal-organic frameworks (MOFs), a class of organic-inorganic hybrid materials built from metal-connecting nodes and organic-bridging ligands. The modular nature of these materials allows to design focused structures by combining properly metal, organic ligands and rigid polytopic spacers. Intriguingly, chiral ligands introduce molecular chirality in the MOF-network as well as homochirality in the secondary structure of materials (such as homohelicity) producing homochiral nets in a manner mimicking biopolymers (proteins, polysaccharides) which are characterized by a definite helical sense associated with the chirality of their building blocks (amino acids or sugars). Nowadays, robust and flexible materials characterized by high porosity and surface area became available by using preparative procedures typical of the so-called reticular synthesis. This review focuses on recent developments in the synthesis and applications of homochiral MOFs as supports for chromatography enantioseparations. Indeed, despite this field is in its infancy, interesting results have been produced and a critical overview of the 12 reported applications for gas chromatography (GC) and high-performance liquid chromatography (HPLC) can orient the reader approaching the field. Mechanistic aspects are shortly discussed and a view regarding future trends in this field is provided.
authors.affiliation: Istituto di Chimica Biomolecolare ICB CNR-UOS di Sassari, Traversa La Crucca 3, Regione Baldinca, Li Punti, I-07100 Sassari, Italy. Electronic address: p.peluso@icb.cnr.it.
authors.forename: Paola
authors.initials: P
authors.lastname: Peluso
authors.affiliation: Institut de Chimie de Strasbourg, UMR 7177, Equipe LASYROC, 1 rue Blaise Pascal, BP 296 R8, 67008 Strasbourg Cedex, France.
authors.forename: Victor
authors.initials: V
authors.lastname: Mamane
authors.affiliation: Dipartimento di Scienze Molecolari e Nanosistemi, Università Ca' Foscari di Venezia, Dorsoduro 2137, I-30123 Venezia, Italy.
authors.forename: Sergio
authors.initials: S
authors.lastname: Cossu
mesh_terms: D002845:Chromatography; D002849:Chromatography, Gas / Q000379:methods*; D002853:Chromatography, Liquid / Q000379:methods*; D008024:Ligands; D008670:Metals / Q000737:chemistry*; D009930:Organic Chemicals / Q000737:chemistry*; D016062:Porosity; D013237:Stereoisomerism
chemical_list: D008024:Ligands; D008670:Metals; D009930:Organic Chemicals
keywords: Chiral stationary phases; Enantioseparation; GC; HPLC; Metal-organic framework