title: Adnexal masses requiring surgical intervention in women with advanced cervical cancer.
abstract: OBJECTIVE
  Surgical evaluation of adnexal masses in patients with cervical cancer can be considered in order to optimize treatment outcomes and rule out a second pathologic process. Our objective was to review treatment patterns and outcomes in women with advanced cervical cancer (ACC) and an adnexal mass.
  
  
  METHODS
  A retrospective review was performed with IRB approval of patients treated for advanced cervical cancer at our institution between 1990 and 2011. Patients were identified using institutional databases and tumor registries. Descriptive statistics were performed using Microsoft Excel 2011 and Instat was used to perform Fisher's exact test and student T-tests.
  
  
  RESULTS
  Two hundred twenty eight patients with stage IIB-IVB cervical cancer were identified, 50 (22%) of whom had an adnexal mass on initial imaging studies (31 stage IIB, 15 stage IIIB, 3 stage IVA, 3 stage IVB). The mean follow up time of patients with adnexal masses was 22 months (range 3-128 months). Thirteen of 50 (26%) patients underwent surgical evaluation of the adnexal mass. Six were found to have cervical cancer metastatic to the adnexae, while seven had benign adnexal lesions. Thirty-seven of 50 (74%) patients were conservatively managed. All 37 women had cystic masses <8 cm or complex masses <5 cm in size. Thirty-four of the 37 (92%) patients had resolution of their adnexal mass and 3 were deemed stable on follow up imaging. Twenty three percent of surgically managed patients and 57% of conservatively managed patients had disease recurrence (p=0.05). There were no recurrences in the adnexa.
  
  
  CONCLUSIONS
  Twelve percent of women with ACC and an adnexal mass have ovarian metastases. Patients with cystic masses less than 8 cm and complex masses less than 5 cm in size can be expectantly managed.
authors.affiliation: University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: christa.nagel@yahoo.com.
authors.forename: Christa I
authors.initials: CI
authors.lastname: Nagel
authors.affiliation: University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: Saly K
authors.initials: SK
authors.lastname: Thomas
authors.affiliation: University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: Debra L
authors.initials: DL
authors.lastname: Richardson
authors.affiliation: University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: Siobhan M
authors.initials: SM
authors.lastname: Kehoe
authors.affiliation: University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: David S
authors.initials: DS
authors.lastname: Miller
authors.affiliation: University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: Jayanthi S
authors.initials: JS
authors.lastname: Lea
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary* / Q000601:surgery*; D000290:Adnexa Uteri; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000556:secondary* / Q000601:surgery*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000556:secondary* / Q000601:surgery*; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000473:pathology*
keywords: Adnexal mass; Advanced cervical cancer