title: The protective effect of lycopene intake on bone loss in ovariectomized rats.
abstract: Antioxidant lycopene supplementation has been shown to decrease oxidative stress and have beneficial effects on bone health. However, it remains unclear whether lycopene exerts its beneficial effect on bone metabolism through mitigation of oxidative stress in vivo. The aim of this study was to investigate whether lycopene intake protects against bone loss by reducing oxidative stress in ovariectomized rats. Female Sprague-Dawley 6-week-old rats were ovariectomized and randomly divided into four groups according to the lycopene content of their diet: 0, 50, 100, and 200 ppm. The tibial bone mineral density (BMD) in the 50, 100, and 200 ppm groups was significantly higher than that in the 0 ppm group. Serum and urinary bone resorption marker levels were significantly lower in the 50, 100, and 200 ppm groups than in the 0 ppm group. There was no significant difference in systemic oxidative stress markers among all groups. However, systemic oxidative stress levels were inversely correlated with the tibial BMD. Our findings suggest that lycopene intake significantly inhibits bone loss by suppressing bone resorption in ovariectomized rats. Further studies are necessary to clarify the effect of lycopene on oxidative stress in local tissues such as bone tissue.
authors.affiliation: Department of Health and Sport Science, Graduate School of Comprehensive Human Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8574, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Iimura
authors.forename: Umon
authors.initials: U
authors.lastname: Agata
authors.forename: Satoko
authors.initials: S
authors.lastname: Takeda
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Shigeki
authors.initials: S
authors.lastname: Yoshida
authors.forename: Ikuko
authors.initials: I
authors.lastname: Ezawa
authors.forename: Naomi
authors.initials: N
authors.lastname: Omi
mesh_terms: D000135:Acid Phosphatase / Q000097:blood; D000596:Amino Acids / Q000652:urine; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D015519:Bone Density / Q000502:physiology; D001851:Bone Diseases, Metabolic / Q000097:blood / Q000188:drug therapy* / Q000652:urine*; D002338:Carotenoids / Q000627:therapeutic use*; D003849:Deoxyguanosine / Q000652:urine; D005260:Female; D007527:Isoenzymes / Q000097:blood; D000077276:Lycopene; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D000071681:Tartrate-Resistant Acid Phosphatase
chemical_list: D000596:Amino Acids; D000975:Antioxidants; D007527:Isoenzymes; D002338:Carotenoids; C036020:deoxypyridinoline; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase; D003849:Deoxyguanosine; D000077276:Lycopene