title: Human to mosquito transmission of dengue viruses.
abstract: The successful transmission of dengue virus from a human host to a mosquito vector requires a complex set of factors to align. It is becoming increasingly important to improve our understanding of the parameters that shape the human to mosquito component of the transmission cycle so that vaccines and therapeutic antivirals can be fully evaluated and epidemiological models refined. Here we describe these factors, and discuss the biological and environmental impacts and demographic changes that are influencing these dynamics. Specifically, we examine features of the human infection required for the mosquito to acquire the virus via natural blood feeding, as well as the biological and environmental factors that influence a mosquito's susceptibility to infection, up to the point that they are capable of transmitting the virus to a new host.
authors.affiliation: Dengue Group, Oxford University Clinical Research Unit, Hospital for Tropical Diseases , Ho Chi Minh City , Vietnam ; Department of Microbiology and Immunology, The University of Melbourne , Melbourne, VIC , Australia.
authors.forename: Lauren B
authors.initials: LB
authors.lastname: Carrington
authors.affiliation: Dengue Group, Oxford University Clinical Research Unit, Hospital for Tropical Diseases , Ho Chi Minh City , Vietnam ; Department of Microbiology and Immunology, The University of Melbourne , Melbourne, VIC , Australia ; Nuffield Department of Clinical Medicine, Centre for Tropical Medicine, University of Oxford , Oxford , UK.
authors.forename: Cameron P
authors.initials: CP
authors.lastname: Simmons
keywords: Aedes aegypti; Aedes albopictus; dengue virus; symptomatic vs. asymptomatic infections; temperature; transmission; viral titer