title: Liposomal spherical nucleic acids.
abstract: A novel class of metal-free spherical nucleic acid nanostructures was synthesized from readily available starting components. These particles consist of 30 nm liposomal cores, composed of an FDA-approved 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) lipid monomer. The surface of the liposomes was functionalized with DNA strands modified with a tocopherol tail that intercalates into the phospholipid layer of the liposomal core via hydrophobic interactions. The spherical nucleic acid architecture not only stabilizes these constructs but also facilitates cellular internalization and gene regulation in SKOV-3 cells.
authors.affiliation: International Institute of Nanotechnology, ‡Department of Chemical and Biological Engineering, §Department of Chemistry, and ⊥Department of Biomedical Engineering, Northwestern University , 2145 Sheridan Road, Evanston, Illinois 60208, United States.
authors.forename: Resham J
authors.initials: RJ
authors.lastname: Banga
authors.forename: Natalia
authors.initials: N
authors.lastname: Chernyak
authors.forename: Suguna P
authors.initials: SP
authors.lastname: Narayan
authors.forename: SonBinh T
authors.initials: ST
authors.lastname: Nguyen
authors.forename: Chad A
authors.initials: CA
authors.lastname: Mirkin
mesh_terms: D002460:Cell Line; D004247:DNA / Q000737:chemistry; D005786:Gene Expression Regulation; D007364:Intercalating Agents; D008051:Lipid Bilayers; D008081:Liposomes / Q000737:chemistry*; D009696:Nucleic Acids / Q000737:chemistry*; D010713:Phosphatidylcholines / Q000737:chemistry; D024505:Tocopherols / Q000737:chemistry
chemical_list: D007364:Intercalating Agents; D008051:Lipid Bilayers; D008081:Liposomes; D009696:Nucleic Acids; D010713:Phosphatidylcholines; D004247:DNA; C017251:1,2-oleoylphosphatidylcholine; D024505:Tocopherols