title: Deferoxamine compensates for decreases in B cell counts and reduces mortality in enterovirus 71-infected mice.
abstract: Enterovirus 71 is one of the major causative agents of hand, foot and mouth disease in children under six years of age. No vaccine or antiviral therapy is currently available. In this work, we found that the number of B cells was reduced in enterovirus 71-infected mice. Deferoxamine, a marine microbial natural product, compensated for the decreased levels of B cells caused by enterovirus 71 infection. The neutralizing antibody titer was also improved after deferoxamine treatment. Furthermore, deferoxamine relieved symptoms and reduced mortality and muscle damage caused by enterovirus 71 infection. This work suggested that deferoxamine has the potential for further development as a B cell-immunomodulator against enterovirus 71.
authors.affiliation: Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, CAMS & Comparative Medicine Centre, Peking Union Medical College, Beijing 100021, China. yangyajun484@hotmail.com.
authors.forename: Yajun
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, CAMS & Comparative Medicine Centre, Peking Union Medical College, Beijing 100021, China. alanyingtao519@163.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Ma
authors.affiliation: Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, CAMS & Comparative Medicine Centre, Peking Union Medical College, Beijing 100021, China. xiujinghui1984@163.com.
authors.forename: Jinghui
authors.initials: J
authors.lastname: Xiu
authors.affiliation: Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, CAMS & Comparative Medicine Centre, Peking Union Medical College, Beijing 100021, China. bailin49@163.com.
authors.forename: Lin
authors.initials: L
authors.lastname: Bai
authors.affiliation: Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, CAMS & Comparative Medicine Centre, Peking Union Medical College, Beijing 100021, China. guanff@cnilas.org.
authors.forename: Feifei
authors.initials: F
authors.lastname: Guan
authors.affiliation: Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, CAMS & Comparative Medicine Centre, Peking Union Medical College, Beijing 100021, China. zhangl@cnilas.org.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, CAMS & Comparative Medicine Centre, Peking Union Medical College, Beijing 100021, China. liujn@cnilas.org.
authors.forename: Jiangning
authors.initials: J
authors.lastname: Liu
authors.affiliation: Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, CAMS & Comparative Medicine Centre, Peking Union Medical College, Beijing 100021, China. zhanglf@cnilas.org.
authors.forename: Lianfeng
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects*; D003676:Deferoxamine / Q000494:pharmacology / Q000627:therapeutic use*; D029821:Enterovirus A, Human; D004769:Enterovirus Infections / Q000188:drug therapy* / Q000276:immunology / Q000401:mortality; D051379:Mice; D019562:Viral Load
chemical_list: D003676:Deferoxamine