title: Association study between interleukin-12 receptor β1/β2 genes and allergic rhinitis in the Chinese Han population.
abstract: Interleukin-12 (IL-12) plays a key role in the protection against allergic reaction induced by allergen as well as the differentiation of T helper 1 cells in patients with allergic rhinitis (AR), exerting its biological effects through binding to specific IL-12 receptors (IL-12Rs) termed IL-12Rβ1 and IL-12Rβ2. In this study, we investigated the relationship between polymorphisms in the IL-12R gene and AR in the Chinese Han population. A total of 543 patients with AR and 749 normal controls were genotyped for IL-12Rβ1/rs438421, IL-12Rβ2/rs3790565, rs3790567, and rs6679356 using a PCR restriction fragment length polymorphism analysis. The association study of each polymorphism of the IL-12Rβ1 and IL-12Rβ2 gene and AR showed that a significantly increased prevalence of the homozygous rs438421 GG genotype and G allele appeared in the AR patients compared with healthy controls. A significantly decreased prevalence of AG in rs438421 in AR patients is compared with healthy controls. Our research demonstrated an important association between polymorphisms in IL-12Rβ1 and AR in the Chinese Han population. A strong association between rs438421 in a single nucleotide polymorphism of IL-12Rβ1 and AR was identified.
authors.affiliation: Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, 1# Yixueyuan Road, Chongqing, 400016, China.|Department of Otolaryngology, The Children's Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Wei
authors.affiliation: Department of Otolaryngology, The Children's Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Kou
authors.affiliation: Department of Physical Examination, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Sun
authors.affiliation: Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, 1# Yixueyuan Road, Chongqing, 400016, China.
authors.forename: Guo-Hua
authors.initials: GH
authors.lastname: Hu
authors.affiliation: Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, 1# Yixueyuan Road, Chongqing, 400016, China.
authors.forename: Di
authors.initials: D
authors.lastname: Hu
authors.affiliation: Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, 1# Yixueyuan Road, Chongqing, 400016, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Feng
authors.affiliation: Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, 1# Yixueyuan Road, Chongqing, 400016, China.
authors.forename: Su-Ling
authors.initials: SL
authors.lastname: Hong
authors.affiliation: Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, 1# Yixueyuan Road, Chongqing, 400016, China. kang.houyong@sohu.com.
authors.forename: Hou-Yong
authors.initials: HY
authors.lastname: Kang
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D006720:Homozygote; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D065840:Protective Factors; D053707:Receptors, Interleukin-12 / Q000235:genetics*; D065631:Rhinitis, Allergic / Q000235:genetics*
chemical_list: C508438:IL12RB1 protein, human; C508439:IL12RB2 protein, human; D053707:Receptors, Interleukin-12