title: Cellular and molecular mechanisms of bone damage and repair in inflammatory arthritis.
abstract: Bone remodelling relies on tightly controlled cycles of bone resorption and formation, mediated by osteoclasts and osteoblasts, respectively. The past two decades have seen a huge increase in our understanding of immune modulation and disruption of bone homeostasis in rheumatic diseases; identification of the molecular pathways responsible for accelerated bone loss in such conditions has given rise to potential novel therapeutic targets. Most recently, the role of microRNAs in inflammatory and noninflammatory bone loss raises the intriguing possibility that modification of cellular protein translation could also be a treatment strategy for bone damage.
authors.affiliation: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Botnar Research Centre, Oxford, UK. Electronic address: Catherine.Swales@ndorms.ox.ac.uk.
authors.forename: Catherine
authors.initials: C
authors.lastname: Swales
authors.affiliation: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Botnar Research Centre, Oxford, UK.
authors.forename: Afsie
authors.initials: A
authors.lastname: Sabokbar
mesh_terms: D000818:Animals; D001168:Arthritis / Q000235:genetics / Q000503:physiopathology*; D016723:Bone Remodeling / Q000235:genetics / Q000502:physiology*; D001842:Bone and Bones / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000503:physiopathology*; D010006:Osteoblasts / Q000502:physiology; D010010:Osteoclasts / Q000502:physiology