title: Bone marrow adipose tissue is an endocrine organ that contributes to increased circulating adiponectin during caloric restriction.
abstract: The adipocyte-derived hormone adiponectin promotes metabolic and cardiovascular health. Circulating adiponectin increases in lean states such as caloric restriction (CR), but the reasons for this paradox remain unclear. Unlike white adipose tissue (WAT), bone marrow adipose tissue (MAT) increases during CR, and both MAT and serum adiponectin increase in many other clinical conditions. Thus, we investigated whether MAT contributes to circulating adiponectin. We find that adiponectin secretion is greater from MAT than WAT. Notably, specific inhibition of MAT formation in mice results in decreased circulating adiponectin during CR despite unaltered adiponectin expression in WAT. Inhibiting MAT formation also alters skeletal muscle adaptation to CR, suggesting that MAT exerts systemic effects. Finally, we reveal that both MAT and serum adiponectin increase during cancer therapy in humans. These observations identify MAT as an endocrine organ that contributes significantly to increased serum adiponectin during CR and perhaps in other adverse states.
authors.affiliation: Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.|Musculoskeletal Research, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
authors.forename: William P
authors.initials: WP
authors.lastname: Cawthorn
authors.affiliation: Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
authors.forename: Erica L
authors.initials: EL
authors.lastname: Scheller
authors.affiliation: Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
authors.forename: Brian S
authors.initials: BS
authors.lastname: Learman
authors.affiliation: Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
authors.forename: Sebastian D
authors.initials: SD
authors.lastname: Parlee
authors.affiliation: Program in Cell and Molecular Biology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
authors.forename: Becky R
authors.initials: BR
authors.lastname: Simon
authors.affiliation: Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Mori
authors.affiliation: Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.|College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, People's Republic of China.
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Ning
authors.affiliation: Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Bree
authors.affiliation: Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Schell
authors.affiliation: Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
authors.forename: David T
authors.initials: DT
authors.lastname: Broome
authors.affiliation: Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
authors.forename: Sandra S
authors.initials: SS
authors.lastname: Soliman
authors.affiliation: Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
authors.forename: Jenifer L
authors.initials: JL
authors.lastname: DelProposto
authors.affiliation: Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.|Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
authors.forename: Carey N
authors.initials: CN
authors.lastname: Lumeng
authors.affiliation: Center for Arrhythmia Research (Department of Internal Medicine - Cardiology), University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
authors.forename: Aditi
authors.initials: A
authors.lastname: Mitra
authors.affiliation: Center for Arrhythmia Research (Department of Internal Medicine - Cardiology), University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
authors.forename: Sandeep V
authors.initials: SV
authors.lastname: Pandit
authors.affiliation: Department of Vascular Surgery, University of Michigan Hospital, Ann Arbor, MI, 48109, USA.
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Gallagher
authors.affiliation: Department of Orthopaedic Surgery, University of Michigan Hospital, Ann Arbor, MI, 48109, USA.
authors.forename: Joshua D
authors.initials: JD
authors.lastname: Miller
authors.affiliation: Musculoskeletal Research, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
authors.forename: Venkatesh
authors.initials: V
authors.lastname: Krishnan
authors.affiliation: Masonic Cancer Center and Therapeutic Radiology, University of Minnesota, Minneapolis, MN, 55455, USA.
authors.forename: Susanta K
authors.initials: SK
authors.lastname: Hui
authors.affiliation: Department of Radiology, Massachusetts General Hospital, Boston, MA, 02114, USA.
authors.forename: Miriam A
authors.initials: MA
authors.lastname: Bredella
authors.affiliation: Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA, 02114, USA.
authors.forename: Pouneh K
authors.initials: PK
authors.lastname: Fazeli
authors.affiliation: Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA, 02114, USA.
authors.forename: Anne
authors.initials: A
authors.lastname: Klibanski
authors.affiliation: Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT, 06519, USA.
authors.forename: Mark C
authors.initials: MC
authors.lastname: Horowitz
authors.affiliation: Maine Medical Center Research Institute, Scarborough, ME, 04074, USA.
authors.forename: Clifford J
authors.initials: CJ
authors.lastname: Rosen
authors.affiliation: Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.|Program in Cell and Molecular Biology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.|Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
authors.forename: Ormond A
authors.initials: OA
authors.lastname: MacDougald
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000273:Adipose Tissue / Q000378:metabolism*; D052436:Adipose Tissue, White / Q000378:metabolism; D000818:Animals; D001853:Bone Marrow / Q000737:chemistry / Q000378:metabolism*; D031204:Caloric Restriction; D004703:Endocrine System / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D018482:Muscle, Skeletal / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D051153:Wnt Proteins / Q000378:metabolism
chemical_list: D052242:Adiponectin; D051153:Wnt Proteins; C102068:Wnt10b protein, mouse