title: Phytochemical profile and antimicrobial properties of Lotus spp. (Fabaceae).
abstract: The phytochemical profile and antimicrobial activity of cultivar (cv.) extracts of Lotus uliginosus (cvs. Trojan and Serrano), L. tenuis (cv. Larrañaga) and L. corniculatus (cv. São Gabriel) were investigated. The phytochemical analysis revealed tannins, coumarins and flavonoids in all extracts, with variations among cultivars, showing genotypic variability. By High Performance Liquid Chromatographic method, the cvs. Larrañaga and São Gabriel showed the highest percentage of catechin and epicatechin, respectively, and presented rutin, which was not detected in the other ones. These genotypes showed antifungal activity but not antibacterial one. The cv. Larrañaga inhibited the mycelia growth of Alternaria sp. and Fusarium graminearum while the cv. São Gabriel was active only against Alternaria sp. The cultivars showed the greatest amounts of secondary metabolites and demonstrated significant activity against filamentous fungi. The results provide a direction for further research about pharmacological use of Lotus spp.
authors.affiliation: Instituto de Ciências Biológicas, Universidade de Passo Fundo, Passo Fundo, RS, Brasil.
authors.forename: Felipe A
authors.initials: FA
authors.lastname: Girardi
authors.affiliation: Departamento de Patologia Básica,, Setor de Ciências Biológicas, Centro Politécnico, Universidade Federal do Paraná, Curitiba, PR, Brasil.
authors.forename: Fabiana
authors.initials: F
authors.lastname: Tonial
authors.affiliation: Programa de Pós-Graduação em Agronomia, Faculdade de Agronomia e Medicina Veterinária, Universidade de Passo Fundo, Passo Fundo, RS, Brasil.
authors.forename: Silvia O
authors.initials: SO
authors.lastname: Chini
authors.affiliation: Instituto de Ciências Biológicas, Universidade de Passo Fundo, Passo Fundo, RS, Brasil.
authors.forename: Andréa M
authors.initials: AM
authors.lastname: Sobottka
authors.affiliation: Programa de Pós-Graduação em Agronomia, Faculdade de Agronomia e Medicina Veterinária, Universidade de Passo Fundo, Passo Fundo, RS, Brasil.
authors.forename: Simone M
authors.initials: SM
authors.lastname: Scheffer-Basso
authors.affiliation: Instituto de Ciências Biológicas, Universidade de Passo Fundo, Passo Fundo, RS, Brasil.
authors.forename: Charise D
authors.initials: CD
authors.lastname: Bertol
mesh_terms: D000528:Alternaria / Q000187:drug effects; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D003374:Coumarins / Q000302:isolation & purification / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology; D005670:Fusarium / Q000187:drug effects; D005838:Genotype; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D000070116:Lotus / Q000737:chemistry* / Q000145:classification / Q000235:genetics; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D013634:Tannins / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D003374:Coumarins; D005419:Flavonoids; D010936:Plant Extracts; D013634:Tannins