title: Photodegradation of amyloid β and reduction of its cytotoxicity to PC12 cells using porphyrin derivatives.
abstract: A purpose-designed porphyrin-peptide hybrid effectively degraded amyloid β monomer and oligomers associated with Alzheimer's disease. Degradation was achieved using light irradiation in the absence of any additives and under neutral conditions. Moreover, the hybrid effectively neutralized the cytotoxicity of amyloid β in PC12 cells upon photoirradiation.
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan. toshima@applc.keio.ac.jp.
authors.forename: Ayumi
authors.initials: A
authors.lastname: Hirabayashi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Shindo
authors.forename: Kotaro
authors.initials: K
authors.lastname: Oka
authors.forename: Daisuke
authors.initials: D
authors.lastname: Takahashi
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Toshima
mesh_terms: D000595:Amino Acid Sequence; D016229:Amyloid beta-Peptides / Q000737:chemistry* / Q000633:toxicity*; D000818:Animals; D008027:Light; D009842:Oligopeptides / Q000737:chemistry; D016716:PC12 Cells; D010446:Peptide Fragments / Q000737:chemistry* / Q000633:toxicity*; D010782:Photolysis / Q000187:drug effects*; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000494:pharmacology*; D011166:Porphyrins / Q000737:chemistry* / Q000494:pharmacology*; D055503:Protein Multimerization / Q000187:drug effects / Q000528:radiation effects; D051381:Rats
chemical_list: D016229:Amyloid beta-Peptides; D009842:Oligopeptides; D010446:Peptide Fragments; D017319:Photosensitizing Agents; D011166:Porphyrins; C075222:amyloid beta-protein (1-42)