title: Executive summary of the GeSIDA/National AIDS Plan consensus document on antiretroviral therapy in adults infected by the human immunodeficiency virus (updated January 2014).
abstract: In this update, antiretroviral therapy (ART) is recommended for all patients infected by type 1 human immunodeficiency virus (HIV-1). The strength and grade of the recommendation varies with clinical circumstances, number of CD4 cells, comorbid conditions and prevention of transmission of HIV. The objective of ART is to achieve an undetectable plasma viral load. Initial ART should always comprise a combination of 3 drugs, including 2 nucleoside reverse transcriptase inhibitors and a third drug from a different family (non-nucleoside reverse transcriptase inhibitor, protease inhibitor, or integrase inhibitor). This update presents the causes and criteria for switching ART in patients with undetectable plasma viral load and in cases of virological failure. An update is also provided for the specific criteria for ART in special situations (acute infection, HIV-2 infection, and pregnancy) and with comorbid conditions (tuberculosis or other opportunistic infections, kidney disease, liver disease, and cancer).
authors.forename: Juan
authors.initials: J
authors.lastname: Berenguer
authors.forename: Rosa
authors.initials: R
authors.lastname: Polo
authors.forename: Fernando
authors.initials: F
authors.lastname: Lozano
authors.forename: José
authors.initials: J
authors.lastname: López Aldeguer
authors.forename: Antonio
authors.initials: A
authors.lastname: Antela
authors.forename: José Ramón
authors.initials: JR
authors.lastname: Arribas
authors.forename: Víctor
authors.initials: V
authors.lastname: Asensi
authors.forename: José Ramón
authors.initials: JR
authors.lastname: Blanco
authors.forename: Bonaventura
authors.initials: B
authors.lastname: Clotet
authors.forename: Pere
authors.initials: P
authors.lastname: Domingo
authors.forename: María José
authors.initials: MJ
authors.lastname: Galindo
authors.forename: José María
authors.initials: JM
authors.lastname: Gatell
authors.forename: Juan
authors.initials: J
authors.lastname: González-García
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Iribarren
authors.forename: Jaime
authors.initials: J
authors.lastname: Locutura
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: López
authors.forename: Josep
authors.initials: J
authors.lastname: Mallolas
authors.forename: Esteban
authors.initials: E
authors.lastname: Martínez
authors.forename: Celia
authors.initials: C
authors.lastname: Miralles
authors.forename: José M
authors.initials: JM
authors.lastname: Miró
authors.forename: Santiago
authors.initials: S
authors.lastname: Moreno
authors.forename: Rosario
authors.initials: R
authors.lastname: Palacios
authors.forename: María Jesús
authors.initials: MJ
authors.lastname: Pérez Elías
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: Pineda
authors.forename: Daniel
authors.initials: D
authors.lastname: Podzamczer
authors.forename: Joaquín
authors.initials: J
authors.lastname: Portilla
authors.forename: Federico
authors.initials: F
authors.lastname: Pulido
authors.forename: Esteban
authors.initials: E
authors.lastname: Ribera
authors.forename: Melchor
authors.initials: M
authors.lastname: Riera
authors.forename: Rafael
authors.initials: R
authors.lastname: Rubio
authors.forename: Jesús
authors.initials: J
authors.lastname: Santos
authors.forename: Jesús
authors.initials: J
authors.lastname: Sanz
authors.forename: Montserrat
authors.initials: M
authors.lastname: Tuset
authors.forename: Francesc
authors.initials: F
authors.lastname: Vidal
authors.forename: Antonio
authors.initials: A
authors.lastname: Rivero
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D057915:Drug Substitution; D006801:Humans; D013030:Spain
chemical_list: D044966:Anti-Retroviral Agents
keywords: AIDS; Adverse reactions; Antiretroviral drugs; Antiretroviral treatment; Fármacos antirretrovirales; GeSIDA; Guideline; Guía, Recomendaciones; Human immunodeficiency virus infection; Infección por el virus de la inmunodeficiencia humana; Plan Nacional sobre el Sida; Reacciones adversas; Recommendations; Sida; Spanish National AIDS Plan; Tratamiento antirretroviral