title: Lipid-colloid dressing shows improved reepithelialization, pain relief, and corneal barrier function in split-thickness skin-graft donor wound healing.
abstract: Donor-site wound healing was tested with a nonadherent petrolatum- and hydrocolloid-impregnated polyester, a lipid-colloid dressing, and a nonadherent polyester dressing, supplemented with petrolatum manually by a physician onsite. Ten patients, 1 woman and 9 men (22 to 79 years old; average 58.4 ± 17.54 years), were enrolled in this prospective comparison study. The split-thickness skin graft was 14.5 ± 7.49 cm long × 8.2 ± 4.07 cm wide (5.5-27 cm long and 4.0-14.0 wide) and 14/1000 inches (0.356 mm) deep. The degree of reepithelialization in lipid-colloid dressing was significantly better than that in polyester mesh dressing, with 1.7 ± 1.00 and 2.8 ± 0.83 for the lipid-colloid dressing and polyester mesh dressing, respectively (P < .05), and degree of pain was significantly lower in lipid-colloid dressing than that in polyester dressing, 1.7 ± 1.11 and 2.9 ± 1.12 for the lipid-colloid dressing and polyester mesh dressing, respectively (P < .01). In moisture meter analyses, the values of effective contact coefficient and corneal thickness in lipid-colloid at wound healing was significantly smaller than those in polyester mesh (effective contact coefficient: 11.7 ± 1.87% and 15.6 ± 3.09% for lipid-colloid and polyester mesh, respectively, P < .05; corneal thickness: 31.1 ± 6.65 µm and 40.7 ± 8.69 µm for lipid-colloid and polyester mesh, respectively, P < .05). No significant difference was observed at 1 month after healing. The nonadherent lipid-colloid polyester dressing has superior wound healing and pain relief and demonstrates better corneal barrier function delineated by effective contact coefficient and corneal thickness at healing in split-thickness donors.
authors.affiliation: Nagasaki University, Nagasaki, Japan.
authors.forename: Katsuya
authors.initials: K
authors.lastname: Tanaka
authors.affiliation: Nagasaki University, Nagasaki, Japan akitas@hf.rim.or.jp.
authors.forename: Sadanori
authors.initials: S
authors.lastname: Akita
authors.affiliation: Nagasaki University, Nagasaki, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoshimoto
authors.affiliation: Nagasaki University, Nagasaki, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Houbara
authors.affiliation: Nagasaki University, Nagasaki, Japan.
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Hirano
mesh_terms: D000293:Adolescent; D000368:Aged; D001458:Bandages; D003102:Colloids; D005260:Female; D006801:Humans; D008055:Lipids; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000628:therapy*; D011446:Prospective Studies; D016038:Skin Transplantation; D060053:Transplant Donor Site; D014945:Wound Healing; D055815:Young Adult
chemical_list: D003102:Colloids; D008055:Lipids
keywords: donor site; nonadherent lipid-colloid dressing; nonadherent polyester mesh; quality of wound healing