title: Obstructive jaundice and perioperative management.
abstract: The causes of obstructive jaundice are varied, but it is most commonly due to choledocholithiasis; benign strictures of the biliary tract; pancreaticobiliary malignancies; and metastatic disease. Surgery in patients with obstructive jaundice is generally considered to be associated with a higher incidence of complications and mortality. Therefore, it poses a considerable challenge to the anesthesiologist, surgeons, and the intensive care team. However, appropriate preoperative evaluation and optimization can greatly contribute to a favorable outcome for perioperative jaundiced patients. This article outlines the association between obstructive jaundice and perioperative management, and reviews the clinical and experimental studies that have contributed to our knowledge of the underlying pathophysiologic mechanisms. Pathophysiology caused by obstructive jaundice involving coagulopathies, infection, renal dysfunction, and other adverse events should be fully assessed and reversed preoperatively. The depressed cardiovascular effects of obstructive jaundice are worth noticing because it has complicated mechanisms and needs to be further explored. Alterations of anesthesia-related drugs induced by obstructive jaundice are varied and clinicians should be aware of the possible need for a decrease in the anesthetic dose. Recommendations concerning the perioperative management of the patients with obstructive jaundice including preoperative biliary drainage, anti-infection, nutrition support, coagulation reversal, cardiovascular evaluation, perioperative fluid therapy, and hemodynamic optimization should be taken.
authors.affiliation: Department of Anesthesia and Intensive Care, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Long
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Anesthesia and Intensive Care, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China. Electronic address: ywf808@yeah.net.
authors.forename: Wei-Feng
authors.initials: WF
authors.lastname: Yu
mesh_terms: D000758:Anesthesia; D018988:Bacterial Translocation / Q000502:physiology; D002320:Cardiovascular Physiological Phenomena; D006801:Humans; D041781:Jaundice, Obstructive / Q000150:complications* / Q000503:physiopathology; D007668:Kidney / Q000503:physiopathology; D044342:Malnutrition / Q000503:physiopathology; D008564:Membrane Potentials / Q000502:physiology; D009569:Nitric Oxide / Q000502:physiology; D019990:Perioperative Care / Q000379:methods*; D015221:Potassium Channels / Q000502:physiology
chemical_list: D015221:Potassium Channels; D009569:Nitric Oxide
keywords: anesthesia; cardiovascular system; jaundice, obstructive; perioperative care