title: Ni(II) and Zn(II) complexes of 2-((thiophen-2-ylmethylene)amino)benzamide: synthesis, spectroscopic characterization, thermal, DFT and anticancer activities.
abstract: The paper presents the synthesis of Ni(II) and Zn(II) complexes of general composition M(L)X₂ and M(L)₂X₂ (M=Ni(II), Zn(II), X=Cl(-1), OAc(-1)) with Schiff base obtained through the condensation of 2-aminobenzamide with thiophene-2-carbaldehyde. The characterization of newly formed complexes was done by (1)H NMR, UV-VIS, TGA, IR, mass spectrophotometry and molar conductivity studies. The thermal studies suggested that the complexes are more stable as compared to ligand. In DFT studies the geometries of Schiff's base and metal complexes were fully optimized with respect to the energy using the 6-31+g(d,p) basis set. On the basis of the spectral studies a distorted octahedral geometry has been assigned for Ni(II) complexes and tetrahedral geometry for Zn(II) complexes. The effect of these complexes on proliferation of human breast cancer cell line (MCF-7) and human hepatocellular liver carcinoma cell line (HepG2) were studied and compared with those of free ligand.
authors.affiliation: Department of Chemistry, Zakir Husain Delhi College, University of Delhi, JLN-Marg, New Delhi 110002, India; Department of Chemistry, School of Sciences, IGNOU, Maidan Garhi, New Delhi 110068, India.
authors.forename: Prateek
authors.initials: P
authors.lastname: Tyagi
authors.affiliation: Department of Chemistry, Zakir Husain Delhi College, University of Delhi, JLN-Marg, New Delhi 110002, India. Electronic address: schandra_00@yahoo.com.
authors.forename: Sulekh
authors.initials: S
authors.lastname: Chandra
authors.affiliation: Department of Chemistry, School of Sciences, IGNOU, Maidan Garhi, New Delhi 110068, India.
authors.forename: B S
authors.initials: BS
authors.lastname: Saraswat
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D056945:Hep G2 Cells / Q000187:drug effects; D006801:Humans; D008024:Ligands; D061986:MCF-7 Cells / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008280:Magnetics; D015394:Molecular Structure; D012545:Schiff Bases / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013818:Thermogravimetry; D017967:Zinc Compounds / Q000737:chemistry / Q000494:pharmacology; D062367:ortho-Aminobenzoates / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D008024:Ligands; D012545:Schiff Bases; D017967:Zinc Compounds; D062367:ortho-Aminobenzoates; C000219:anthranilamide
keywords: Anticancer activity; DFT calculations; Ni(II) and Zn(II) complexes; Schiff base; Spectroscopic studies