title: Accuracy of GastroPanel for the diagnosis of atrophic gastritis.
abstract: BACKGROUND
  It has been suggested that GastroPanel might be a useful tool for the diagnosis of chronic atrophic gastritis (CAG) measuring four biomarkers in blood: basal gastrin-17 (G17), pepsinogen I and II (PGI and PGII), and Helicobacter pylori antibodies.
  
  
  OBJECTIVE
  To determine the accuracy of GastroPanel for the diagnosis of CAG.
  
  
  METHODS
  This was a prospective, blinded, multicenter study that included dyspeptic patients. G17, PGI, and PGII were determined by enzyme immunoassays. Three antrum and two corpus biopsies were obtained for standard histological analysis and rapid urease test. Biopsies were analyzed by a single blinded expert pathologist.
  
  
  RESULTS
  Ninety-one patients were included (77% women, mean age 44 years, 51% H. pylori positive, 17% with CAG). G17 was reduced in patients with antrum CAG (5.4 vs. 13.4 pmol/l; P<0.01) and increased in patients with corpus CAG (11 vs. 24 pmol/l; P<0.05), but its accuracy was only acceptable in the case of corpus localization [area under the receiver operating characteristic curve (AUC), 74%]; PGII difference was almost statistically significant only when testing for corpus atrophy (33 vs. 21 μg/l; P=0.05; AUC=72%). The PGI and PGI/PGII ratio showed no significant differences (AUCs were all unacceptably low). Helicobacter pylori antibody levels were higher in H. pylori-infected patients (251 vs. 109 EIU, P=0.01; AUC=70). The accuracy of GastroPanel for the diagnosis of CAG was as follows: sensitivity 50%; specificity 80%; positive 25% and negative 92% predictive values; and positive 2.4 and negative 0.6 likelihood ratios.
  
  
  CONCLUSIONS
  GastroPanel is not accurate enough for the diagnosis of CAG; thus, its systematic use in clinical practice cannot be recommended.
authors.affiliation: aHospital of La Princesa, and Instituto de Investigación Sanitaria Princesa bCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain Gastroenterology Units of cHospital Mutua de Terrassa, Terrassa dHospital del Mar, Barcelona eHospital Rio Hortega, Valladolid fHospital de Cabueñes, Gijon gHospital Costa del Sol, Malaga hHospital San Jorge, Huesca iHospital Clínico de Zaragoza, Zaragoza jHospital Virgen de la Salud, Toledo.
authors.forename: Adrian G
authors.initials: AG
authors.lastname: McNicholl
authors.forename: Montserrat
authors.initials: M
authors.lastname: Forné
authors.forename: Jesus
authors.initials: J
authors.lastname: Barrio
authors.forename: Cristobal
authors.initials: C
authors.lastname: De la Coba
authors.forename: Begoña
authors.initials: B
authors.lastname: González
authors.forename: Robin
authors.initials: R
authors.lastname: Rivera
authors.forename: Maria
authors.initials: M
authors.lastname: Esteve
authors.forename: Fernando
authors.initials: F
authors.lastname: Fernandez-Bañares
authors.forename: Beatriz
authors.initials: B
authors.lastname: Madrigal
authors.forename: Beatriz
authors.initials: B
authors.lastname: Gras-Miralles
authors.forename: Angeles
authors.initials: A
authors.lastname: Perez-Aisa
authors.forename: Jose M
authors.initials: JM
authors.lastname: Viver-Pi-Sunyer
authors.forename: Felipe
authors.initials: F
authors.lastname: Bory
authors.forename: Merce
authors.initials: M
authors.lastname: Rosinach
authors.forename: Carmen
authors.initials: C
authors.lastname: Loras
authors.forename: Carlos
authors.initials: C
authors.lastname: Esteban
authors.forename: Santos
authors.initials: S
authors.lastname: Santolaria
authors.forename: Fernando
authors.initials: F
authors.lastname: Gomollon
authors.forename: Julio
authors.initials: J
authors.lastname: Valle
authors.forename: Javier P
authors.initials: JP
authors.lastname: Gisbert
mesh_terms: D000328:Adult; D000465:Algorithms; D000907:Antibodies, Bacterial / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D001706:Biopsy; D002908:Chronic Disease; D004311:Double-Blind Method; D005260:Female; D005755:Gastrins / Q000097:blood; D005757:Gastritis, Atrophic / Q000175:diagnosis* / Q000382:microbiology; D016481:Helicobacter Infections / Q000150:complications; D016480:Helicobacter pylori / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020116:Pepsinogen A / Q000097:blood; D020115:Pepsinogen C / Q000097:blood; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011706:Pyloric Antrum / Q000473:pathology; D013270:Stomach / Q000473:pathology
chemical_list: D000907:Antibodies, Bacterial; D015415:Biomarkers; D005755:Gastrins; C013550:gastrin 17; D020115:Pepsinogen C; D020116:Pepsinogen A