title: Fluorous chiral bisoxazolines: application in copper-catalyzed asymmetric α-hydrophosphonylation.
abstract: A copper-catalyzed asymmetric α-hydrophosphonylation of isatins with a novel fluorous bis(oxazoline) as a ligand is presented. The corresponding chiral α(1)-oxindole-α-hydroxyphosphonates were obtained in 30-91% yield with enantioselectivities up to 92%. The fluorous ligand can be easily recovered and reused at least 3 times without a significant loss in its activity.
authors.affiliation: Chemical Engineering College, Nanjing University of Science & Technology, Nanjing, Jiangsu 210094, P. R. China. c.cai@njust.edu.cn.
authors.forename: Tao
authors.initials: T
authors.lastname: Deng
authors.forename: Hongjun
authors.initials: H
authors.lastname: Wang
authors.forename: Chun
authors.initials: C
authors.lastname: Cai