title: Notch one up to stroma: endothelial notch prevents inflammation and myeloproliferation.
abstract: In this issue of Cell Stem Cell, Wang et al. (2014) describe a signaling axis present in bone marrow stromal cells that suppresses inflammation and myeloid expansions. Loss of endothelial Notch signaling leads to deregulation of miR-155 expression, activation of NF-kB, and increased proinflammatory cytokine production, which promotes a myeloproliferative phenotype.
authors.affiliation: Human Oncology and Pathogenesis Program, Departments of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Weill Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA.
authors.forename: Mona
authors.initials: M
authors.lastname: Khalaj
authors.affiliation: Human Oncology and Pathogenesis Program, Departments of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Weill Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA. Electronic address: parkc@mskcc.org.
authors.forename: Christopher Y
authors.initials: CY
authors.lastname: Park
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000502:physiology*; D019337:Hematologic Neoplasms / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D009196:Myeloproliferative Disorders / Q000235:genetics*; D051880:Receptors, Notch / Q000378:metabolism*
chemical_list: D035683:MicroRNAs; C532623:Mirn155 microRNA, mouse; D051880:Receptors, Notch