title: The role of ubiquitination and sumoylation in diabetic nephropathy.
abstract: Diabetic nephropathy (DN) is a common and characteristic microvascular complication of diabetes; the mechanisms that cause DN have not been clarified, and the epigenetic mechanism was promised in the pathology of DN. Furthermore, ubiquitination and small ubiquitin-like modifier (SUMO) were involved in the progression of DN. MG132, as a ubiquitin proteasome, could improve renal injury by regulating several signaling pathways, such as NF- κ B, TGF- β , Nrf2-oxidative stress, and MAPK. In this review, we summarize how ubiquitination and sumoylation may contribute to the pathology of DN, which may be a potential treatment strategy of DN.
authors.affiliation: Department of Endocrinology, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000, China.
authors.forename: Chenlin
authors.identifier: 0000-0003-2464-9325
authors.initials: C
authors.lastname: Gao
authors.affiliation: Department of Endocrinology, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.affiliation: Division of Diabetology and Endocrinology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan.
authors.forename: Keizo
authors.initials: K
authors.lastname: Kanasaki
authors.affiliation: Department of Endocrinology, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000, China.
authors.forename: Yong
authors.identifier: 0000-0002-9534-6252
authors.initials: Y
authors.lastname: Xu
mesh_terms: D003928:Diabetic Nephropathies / Q000235:genetics* / Q000473:pathology; D044127:Epigenesis, Genetic; D006801:Humans; D020929:Mitogen-Activated Protein Kinase Kinases / Q000235:genetics; D051267:NF-E2-Related Factor 2 / Q000235:genetics; D016328:NF-kappa B / Q000235:genetics; D018384:Oxidative Stress; D015398:Signal Transduction / Q000235:genetics; D058207:Sumoylation / Q000235:genetics*; D016212:Transforming Growth Factor beta / Q000235:genetics; D054875:Ubiquitination / Q000235:genetics*
chemical_list: D051267:NF-E2-Related Factor 2; D016328:NF-kappa B; C495635:NFE2L2 protein, human; D016212:Transforming Growth Factor beta; D020929:Mitogen-Activated Protein Kinase Kinases