title: Optical diagnostic techniques for use in lesions of the head and neck: review of the latest developments.
abstract: Optical biopsy systems are a potential adjunct to the histopathological assessment of tissue specimens; they are not invasive and can give an immediate result. We review the most common optical biopsy techniques used to detect lesions of the head and neck: elastic scattering spectroscopy, microendoscopy, narrow band imaging, fluorescence, and optical coherence tomography, and discuss their clinical use.
authors.affiliation: Craniofacial Unit, Great Ormond Street Hospital for Children, London, UK; King's College London School of Medicine, Guy's Campus, London, UK. Electronic address: ben.c.green@kcl.ac.uk.
authors.forename: Ben
authors.initials: B
authors.lastname: Green
authors.affiliation: South-West Cleft Unit & Department of Oral and Maxillofacial Surgery, North Bristol NHS Trust, Bristol, UK.
authors.forename: Alistair R M
authors.initials: AR
authors.lastname: Cobb
authors.affiliation: Department of Oral & Maxillofacial Surgery, Queen Alexandra Hospital, Portsmouth, UK.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Brennan
authors.affiliation: Head & Neck Unit, University College London Hospital, London, UK.
authors.forename: Colin
authors.initials: C
authors.lastname: Hopper
mesh_terms: D001706:Biopsy / Q000379:methods; D054459:Elasticity Imaging Techniques; D004724:Endoscopy / Q000379:methods; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D061848:Optical Imaging / Q000379:methods*; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000473:pathology; D013057:Spectrum Analysis / Q000379:methods
keywords: elastic scattering spectroscopy; fluorescence; microendoscopy; narrow-band imaging; optical biopsy; optical coherence tomography; oral cancer; skin cancer