title: Copper(I)-catalyzed multicomponent reaction providing a new access to fully substituted thiophene derivatives.
abstract: Readily available triethylammonium 1-(2-oxoindolin-3-ylidene)-2-aroylethanethiolates are efficiently converted into a variety of fully substituted thiophene derivatives by copper(I)-catalyzed denitrogenative reactions with terminal alkynes and N-sulfonyl azides. This new reaction simultaneously installs C-N, C-S, and C-C bonds, allowing direct formation of highly functionalized thiophenes with a wide diversity in substituents in a one-pot manner. A plausible mechanism for the domino process is proposed.
authors.affiliation: School of Chemistry and Chemical Engineering, and Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University , Xuzhou, 221116, Jiangsu P. R. China.
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
authors.forename: Xing-Jun
authors.initials: XJ
authors.lastname: Tu
authors.forename: Xue
authors.initials: X
authors.lastname: Wang
authors.forename: Shu-Jiang
authors.initials: SJ
authors.lastname: Tu
authors.forename: Guigen
authors.initials: G
authors.lastname: Li
mesh_terms: D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007454:Iodides / Q000737:chemistry*; D015394:Molecular Structure; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D001386:Azides; D007454:Iodides; D013876:Thiophenes; D003300:Copper; C073870:cuprous iodide