title: Metal-free C-H amination for indole synthesis.
abstract: An effective metal-free C-H amination of N-Ts-2-alkenylanilines by using DDQ as an oxidant has been developed to afford a diverse range of substituted indoles. This protocol is operationally simple and robust, obviates the need of expensive transition-metal catalysts, and offers a broad substrate scope. A mechanism involving a radical cation generated by SET and a migratorial process via a phenonium ion intermediate is proposed.
authors.affiliation: Center for New Directions in Organic Synthesis, Department of Chemistry and Research Institute for Natural Sciences, Hanyang University , Seoul 133-791, Korea.
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Jang
authors.forename: So Won
authors.initials: SW
authors.lastname: Youn
mesh_terms: D000586:Amination; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D007211:Indoles