title: Gefitinib-induced skin ulceration in metastatic adenocarcinoma lung.
abstract: We report a case of gefitinib-induced skin ulceration in a 50-year-old female with metastatic adenocarcinoma of lung who developed this adverse effect 2 weeks following initiation of gefitinib at a dose of 250 mg/day. The ulcer improved with stopping gefitinib for 2 weeks and also addition of topical steroids and antibiotics. We are reporting this case to create awareness among treating oncologists of this adverse effect and also prompt interruption of therapy and topical steroids/antibiotics is useful to treat this adverse event.
authors.affiliation: Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India.
authors.forename: Vishwanath
authors.initials: V
authors.lastname: Sathyanarayanan
authors.affiliation: Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India.
authors.forename: Kadabur Nagendrappa
authors.initials: KN
authors.lastname: Lokesh
authors.affiliation: Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India.
authors.forename: Lakshmaiah Kuntejowdahalli
authors.initials: LK
authors.lastname: Channaviriappa
authors.affiliation: Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India.
authors.forename: Linu Abraham
authors.initials: LA
authors.lastname: Jacob
keywords: Epidermal growth factor receptor; gefitinib; skin ulceration; tyrosine kinase inhibitor