title: Accumulation of supramolecular nanoparticles self-assembled from a bola-shaped cytidylic acid-appended fluorescein dye in cell nuclei.
abstract: We examined the cellular uptake of the nanoparticles self-assembled from a bola-shaped cytidylic acid-appended fluorescein derivative (C-FLU-C). The accumulation of fluorescence in the Caco-2 cell nucleus was observed mainly after the plateau phase of cell growth, indicating that C-FLU-C permeated the nuclear envelope without nuclear-localizing tags.
authors.affiliation: National Food Research Institute, National Agriculture and Food Research Organization, 2-1-12 Kannondai, Tsukuba, Ibaraki 305-8642, Japan. riwaura@affrc.go.jp.
authors.forename: Rika
authors.initials: R
authors.lastname: Iwaura
authors.forename: Mutsumi
authors.initials: M
authors.lastname: Shirai
authors.forename: Kaname
authors.initials: K
authors.lastname: Yoshida
authors.forename: Mayumi
authors.initials: M
authors.lastname: Ohnishi-Kameyama
mesh_terms: D018938:Caco-2 Cells; D002467:Cell Nucleus / Q000737:chemistry*; D003568:Cytidine Monophosphate / Q000737:chemistry*; D019793:Fluorescein / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D008856:Microscopy, Fluorescence; D053758:Nanoparticles
chemical_list: D005456:Fluorescent Dyes; D003568:Cytidine Monophosphate; D019793:Fluorescein