title: Urinary KIM-1, NGAL and L-FABP for the diagnosis of AKI in patients with acute coronary syndrome or heart failure undergoing coronary angiography.
abstract: Acute kidney injury (AKI) is a common complication after coronary angiography. Early biomarkers of this disease are needed since increase in serum creatinine levels is a late marker. To assess the usefulness of urinary kidney injury molecule-1 (uKIM-1), neutrophil gelatinase-associated lipocalin (uNGAL) and liver-type fatty acid-binding protein (uL-FABP) for early detection of AKI in these patients, comparing their performance with another group of cardiac surgery patients. Biomarkers were measured in 193 patients, 12 h after intervention. In the ROC analysis, AUC for KIM-1, NGAL and L-FABP was 0.713, 0.958 and 0.642, respectively, in the coronary angiography group, and 0.716, 0.916 and 0.743 in the cardiac surgery group. Urinary KIM-1 12 h after intervention is predictive of AKI in adult patients undergoing coronary angiography, but NGAL shows higher sensitivity and specificity. L-FABP provides inferior discrimination for AKI than KIM-1 or NGAL in contrast to its performance after cardiac surgery. This is the first study showing the predictive capacity of KIM-1 for AKI after coronary angiography. Further studies are still needed to answer relevant questions about the clinical utility of biomarkers for AKI in different clinical settings.
authors.affiliation: Servicio de Nefrología, Hospital Clínico Universitario de Valencia, Av Blasco Ibáñez 17, 46010, Valencia, Spain. isist67@gmail.com.|Departamento de Medicina, Universidad de Valencia, Valencia, Spain. isist67@gmail.com.
authors.forename: Isidro
authors.initials: I
authors.lastname: Torregrosa
authors.affiliation: Fundación Investigación Clínico de Valencia Instituto de Investigación Sanitaria, INCLIVA, Valencia, Spain.|Departamento de Patología, Sección Histología, Facultad de Medicina y Odontología, Universidad de Valencia, Valencia, Spain.
authors.forename: Carmina
authors.initials: C
authors.lastname: Montoliu
authors.affiliation: Fundación Investigación Clínico de Valencia Instituto de Investigación Sanitaria, INCLIVA, Valencia, Spain.
authors.forename: Amparo
authors.initials: A
authors.lastname: Urios
authors.affiliation: Fundación Investigación Clínico de Valencia Instituto de Investigación Sanitaria, INCLIVA, Valencia, Spain.
authors.forename: María Jesús
authors.initials: MJ
authors.lastname: Andrés-Costa
authors.affiliation: Laboratorio de Neurobiología, Centro Investigación Príncipe Felipe, Valencia, Spain.
authors.forename: Carla
authors.initials: C
authors.lastname: Giménez-Garzó
authors.affiliation: Servicio de Nefrología, Hospital Clínico Universitario de Valencia, Av Blasco Ibáñez 17, 46010, Valencia, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Juan
authors.affiliation: Servicio de Nefrología, Hospital Clínico Universitario de Valencia, Av Blasco Ibáñez 17, 46010, Valencia, Spain.|Departamento de Medicina, Universidad de Valencia, Valencia, Spain.
authors.forename: María Jesús
authors.initials: MJ
authors.lastname: Puchades
authors.affiliation: Unidad Coronaria, Hospital Clínico Universitario de Valencia, Valencia, Spain.
authors.forename: María Luisa
authors.initials: ML
authors.lastname: Blasco
authors.affiliation: Laboratorio de Bioquímica Clínica y Patología Molecular, Hospital Clínico Universitario de Valencia, Valencia, Spain.
authors.forename: Arturo
authors.initials: A
authors.lastname: Carratalá
authors.affiliation: Unidad Coronaria, Hospital Clínico Universitario de Valencia, Valencia, Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: Sanjuán
authors.affiliation: Servicio de Nefrología, Hospital Clínico Universitario de Valencia, Av Blasco Ibáñez 17, 46010, Valencia, Spain.|Departamento de Medicina, Universidad de Valencia, Valencia, Spain.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Miguel
mesh_terms: D054058:Acute Coronary Syndrome / Q000150:complications*; D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000209:etiology; D000209:Acute-Phase Proteins / Q000652:urine*; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D015415:Biomarkers / Q000652:urine; D006348:Cardiac Surgical Procedures / Q000009:adverse effects; D017023:Coronary Angiography / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D050556:Fatty Acid-Binding Proteins / Q000652:urine*; D005260:Female; D006333:Heart Failure / Q000150:complications*; D000072596:Hepatitis A Virus Cellular Receptor 1; D006801:Humans; D000071068:Lipocalin-2; D054834:Lipocalins / Q000652:urine*; D008297:Male; D008562:Membrane Glycoproteins / Q000652:urine*; D008875:Middle Aged; D011518:Proto-Oncogene Proteins / Q000652:urine*; D012372:ROC Curve; D011991:Receptors, Virus; D012680:Sensitivity and Specificity; D013030:Spain
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; C493319:FABP1 protein, human; D050556:Fatty Acid-Binding Proteins; C491143:HAVCR1 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D008562:Membrane Glycoproteins; D011518:Proto-Oncogene Proteins; D011991:Receptors, Virus; D003404:Creatinine
keywords: Acute kidney injury; Biomarkers; Cardiac surgery; Coronary angiography; KIM-1; L-FABP; NGAL