title: Endoplasmic reticulum stress suppressive compounds from the edible mushroom Mycoleptodonoides aitchisonii.
abstract: Two novel compounds, 1 and 7, along with six known compounds (2-6 and 8), were isolated from the edible mushroom Mycoleptodonoides aitchisonii (bunaharitake in Japanese). The structures of the new compounds were determined by the interpretation of spectroscopic data. Compounds 1-4 and 6-8 showed protective activity against endoplasmic reticulum stress-dependent cell death.
authors.affiliation: Research Institute of Green Science and Technology, Shizuoka University , 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan.
authors.forename: Jae-Hoon
authors.initials: JH
authors.lastname: Choi
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Suzuki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Okumura
authors.forename: Keiichi
authors.initials: K
authors.lastname: Noguchi
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Kondo
authors.forename: Kaoru
authors.initials: K
authors.lastname: Nagai
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Hirai
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Kawagishi
mesh_terms: D000363:Agaricales / Q000737:chemistry*; D000818:Animals; D016923:Cell Death / Q000187:drug effects; D018360:Crystallography, X-Ray; D059865:Endoplasmic Reticulum Stress; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007564:Japan; D008968:Molecular Conformation; D015394:Molecular Structure; D010420:Pentanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: C000591607:5-hydroxy-4-(1-hydroxyethyl)-3-methylfuran-2(5H)-one; C000591608:5-phenylpentane-1,3,4-triol; D005663:Furans; D010420:Pentanes