title: [A case report of carcinoma in situ of the bladder invading the prostate following BCG therapy].
abstract: A 85-year-old man achieved complete response after a course of intravesical instillation of Bacillus Calmette Guerin (BCG) therapy for carcinoma in situ (CIS) of the bladder. Two year later, urine cytology became class III. We performed random biopsy of the bladder and split urine cytology of the bilateral upper urinary tract, but none of these examinations revealed any malignant features. After a month, he consulted orthopedics for lumbago. He was indicated to have a metastatic bone tumor, and positron emission tomography-computed tomography (PET-CT) showed a hypermetabolic mass in the prostate. A transperineal needle biopsy of the prostate revealed the urothelial carcinoma (UC). Our diagnosis was invasion of CIS of the bladder into the prostate. In such cases, we recommend a needle biopsy of the prostate in addition to a transurethral biopsy of the bladder and prostate.
authors.affiliation: The Department of Urology, Osaka Rosai Hospital.
authors.forename: Makoto
authors.initials: M
authors.lastname: Matsushita
authors.affiliation: The Department of Urology, Osaka Rosai Hospital.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Okada
authors.affiliation: The Department of Urology, Osaka Rosai Hospital.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Koh
authors.affiliation: The Department of Urology, Osaka Rosai Hospital.
authors.forename: Cong
authors.initials: C
authors.lastname: Wang
authors.affiliation: The Department of Urology, Osaka Rosai Hospital.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ujike
authors.affiliation: The Department of Urology, Osaka Rosai Hospital.
authors.forename: Mikio
authors.initials: M
authors.lastname: Nin
authors.affiliation: The Department of Urology, Osaka Rosai Hospital.
authors.forename: Masao
authors.initials: M
authors.lastname: Tsujihata
mesh_terms: D000369:Aged, 80 and over; D002278:Carcinoma in Situ / Q000473:pathology*; D006801:Humans; D008297:Male; D009163:Mycobacterium bovis; D009361:Neoplasm Invasiveness / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000209:etiology / Q000473:pathology*; D001749:Urinary Bladder Neoplasms / Q000473:pathology*