title: Location and removal of deslorelin acetate implants in female African lions (Panthera leo).
abstract: Contraception is necessary to manage zoo animal populations and to be able to house animals in groups without producing additional unwanted offspring. In felids and canids, an association between exposure to progestins and the occurrence of endometrial and mammary gland pathology has been documented. Therefore, the Association of Zoos and Aquariums (AZA) Wildlife Contraceptive Center recommends the use of deslorelin acetate for long-term contraception in carnivores. Return to cyclicity after deslorelin treatment has been variable; some individuals show ovarian suppression for long periods after the expected end of the deslorelin efficacy. In an attempt to reduce the time to reversal, techniques to locate and remove previous implants are being developed. This report documents the successful implementation of high-frequency ultrasonography in lions (Panthera leo) to locate and direct surgical removal of multiple deslorelin implants placed at least 2 yr previously as well as the return of follicular activity in both females at 7 months post-removal of implants.
authors.forename: Anneke
authors.initials: A
authors.lastname: Moresco
authors.forename: Liza
authors.initials: L
authors.lastname: Dadone
authors.forename: Jason
authors.initials: J
authors.lastname: Arble
authors.forename: Eric
authors.initials: E
authors.lastname: Klaphake
authors.forename: Dalen W
authors.initials: DW
authors.lastname: Agnew
mesh_terms: D000818:Animals; D000836:Animals, Zoo; D003271:Contraceptive Agents, Female / Q000494:pharmacology*; D004343:Drug Implants; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005260:Female; D008045:Lions; D017329:Triptorelin Pamoate / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D003271:Contraceptive Agents, Female; D004343:Drug Implants; D004791:Enzyme Inhibitors; D017329:Triptorelin Pamoate; C066438:deslorelin