title: Caffeic acid phenethyl ester as a protective agent against nephrotoxicity and/or oxidative kidney damage: a detailed systematic review.
abstract: Caffeic acid phenethyl ester (CAPE), an active component of propolis, has been attracting the attention of different medical and pharmaceutical disciplines in recent years because of its antioxidant, anti-inflammatory, antiproliferative, cytotoxic, antiviral, antifungal, and antineoplastic properties. One of the most studied organs for the effects of CAPE is the kidney, particularly in the capacity of this ester to decrease the nephrotoxicity induced by several drugs and the oxidative injury after ischemia/reperfusion (I/R). In this review, we summarized and critically evaluated the current knowledge regarding the protective effect of CAPE in nephrotoxicity induced by several special medicines such as cisplatin, doxorubicin, cyclosporine, gentamycin, methotrexate, and other causes leading to oxidative renal injury, namely, I/R models and senility.
authors.affiliation: Division of Medical Laboratory Techniques, Vocational School of Health Sciences, Turgut Ozal University, Çeşme Durağı Spor Kompleksi Arkası, Ostim, Yenimahalle, 06370 Ankara, Turkey ; Department of Biochemistry, Medical Faculty, Gaziosmanpasa University, Tokat, Turkey.
authors.forename: Sumeyya
authors.initials: S
authors.lastname: Akyol
authors.affiliation: Private Bilecik Orhangazi Dialysis Center, Bilecik, Turkey.
authors.forename: Veli
authors.initials: V
authors.lastname: Ugurcu
authors.affiliation: Ankara Branch of Council of Forensic Medicine, Ankara, Turkey.
authors.forename: Aynur
authors.initials: A
authors.lastname: Altuntas
authors.affiliation: Division of Medical Laboratory Techniques, Vocational School of Health Sciences, Turgut Ozal University, Çeşme Durağı Spor Kompleksi Arkası, Ostim, Yenimahalle, 06370 Ankara, Turkey.
authors.forename: Rukiye
authors.initials: R
authors.lastname: Hasgul
authors.affiliation: Department of Biology, Faculty of Education, Gazi University, Ankara, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Cakmak
authors.affiliation: Department of Medical Biochemistry, Medical Faculty, Hacettepe University, Ankara, Turkey ; Division of Chemistry, Ankara Branch of Council of Forensic Medicine, Ankara, Turkey.
authors.forename: Omer
authors.identifier: 0000-0001-5496-9392
authors.initials: O
authors.lastname: Akyol
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control; D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D002109:Caffeic Acids / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects*; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D002109:Caffeic Acids; C055494:caffeic acid phenethyl ester; D010626:Phenylethyl Alcohol