title: Translocation (8;21) acute myeloid leukemia presenting as severe aplastic anemia.
abstract: We report a case of t(8;21) acute myeloid leukemia presenting as severe aplastic anemia. While initial bone marrow biopsy lacked any cytogenetic abnormalities in 20 analyzed metaphases, repeat bone marrow biopsy eight days later demonstrated this translocation. Initial cytogenetic analysis of 20 metaphases was therefore insufficient to make the diagnosis of hypocellular acute myeloid leukemia. We discuss that further complementary molecular tests, such as CGH, would likely provide a more robust diagnosis of hematopoietic diseases.
authors.affiliation: National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20814, United States.
authors.forename: Enkhtsetseg
authors.initials: E
authors.lastname: Purev
authors.affiliation: National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20814, United States.
authors.forename: Bogdan
authors.initials: B
authors.lastname: Dumitriu
authors.affiliation: National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20814, United States.
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Hourigan
authors.affiliation: National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20814, United States.
authors.forename: Neal S
authors.initials: NS
authors.lastname: Young
authors.affiliation: National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20814, United States.
authors.forename: Danielle M
authors.initials: DM
authors.lastname: Townsley
keywords: Acute leukemia; Aplastic anemia; Comparative genomic hybridization; t(8;21)