title: Facile regiospecific synthesis of 2,3-disubstituted indoles from isatins.
abstract: A facile regiospecific synthesis of 2,3-disubstituted indoles from isatins has been developed. Nucleophilic addition of Grignard reagents to commercially available isatins, followed by reduction with borane, afforded an array of structurally diverse 2,3-disubstituted indoles in moderate to good yields. The method described herein represents a novel and very simple approach to synthesize various 2,3-disubstituted indoles, extremely important structural motifs in the pharmaceutical industry and medicinal chemistry.
authors.affiliation: Department of Chemistry and Medicinal Chemistry Program, Life Sciences Institute, National University of Singapore, 3 Science Drive 3, Republic of Singapore 117543. chmlyx@nus.edu.sg.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Dou
authors.forename: Weijun
authors.initials: W
authors.lastname: Yao
authors.forename: Shan
authors.initials: S
authors.lastname: Wen
authors.forename: Yixin
authors.initials: Y
authors.lastname: Lu
mesh_terms: D060326:Chemistry Techniques, Synthetic; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D007510:Isatin / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D007211:Indoles; D007510:Isatin