title: Alternations of galectin levels after renal transplantation.
abstract: OBJECTIVE
  Galectins (gals), a growing family of β-galactoside-binding animal lectins, have been implicated in a variety of biological processes including fibrosis, angiogenesis, and immune activation, all of which are involved in hemodialysis (HD) and renal transplantation (RTx). In this study, we aimed to investigate serum gal levels in HD and RTx recipients.
  
  
  METHODS
  41 normal subjects, 41 RTx recipients and 32 HD patients were recruited for this study. RTx recipients were evaluated before transplantation as well as 3 months afterwards. Serum gals-1, 2, 3, 4, 8, and 9 were measured both at baseline and 3 months later in each group.
  
  
  RESULTS
  At baseline, there were no differences in gals-1, 2, 3, 4, 8, and 9 between the RTx and HD groups. However, the levels of gals-1, 2, 3, 8, and 9 in the RTx and HD groups were higher than that of normal subjects. In paired analyses, gals-1, 2, and 3 were significantly decreased in RTx patients (P<0.0001) at 3 months, while there was no change in the HD group. However, levels of gals-4, 8, and 9 did not significantly change in either the HD or RTx group.
  
  
  CONCLUSIONS
  Gal-1, 2, and 3 levels were high in maintenance HD patients. Kidney transplantation improved gal-1, 2, and 3 levels.
authors.affiliation: Department of Urology, Jiangsu Province Hospital, No. 300 Guangzhou Road, Gulou District, Nanjing, Jiangsu 210029, China.
authors.forename: Ruoyun
authors.initials: R
authors.lastname: Tan
authors.affiliation: Department of Urology, Jiangsu Province Hospital, No. 300 Guangzhou Road, Gulou District, Nanjing, Jiangsu 210029, China.
authors.forename: Xuzhong
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Urology, Jiangsu Province Hospital, No. 300 Guangzhou Road, Gulou District, Nanjing, Jiangsu 210029, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Urology, Jiangsu Province Hospital, No. 300 Guangzhou Road, Gulou District, Nanjing, Jiangsu 210029, China.
authors.forename: Pei
authors.initials: P
authors.lastname: Lu
authors.affiliation: Department of Urology, Jiangsu Province Hospital, No. 300 Guangzhou Road, Gulou District, Nanjing, Jiangsu 210029, China.
authors.forename: Zhijian
authors.initials: Z
authors.lastname: Han
authors.affiliation: Department of Urology, Jiangsu Province Hospital, No. 300 Guangzhou Road, Gulou District, Nanjing, Jiangsu 210029, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Tao
authors.affiliation: Department of Urology, Jiangsu Province Hospital, No. 300 Guangzhou Road, Gulou District, Nanjing, Jiangsu 210029, China.
authors.forename: Changjun
authors.initials: C
authors.lastname: Yin
authors.affiliation: Department of Urology, Jiangsu Province Hospital, No. 300 Guangzhou Road, Gulou District, Nanjing, Jiangsu 210029, China. Electronic address: lancetgu@aliyun.com.
authors.forename: Min
authors.initials: M
authors.lastname: Gu
mesh_terms: D000328:Adult; D005260:Female; D037483:Galectin 1 / Q000097:blood*; D037501:Galectin 2 / Q000097:blood*; D037502:Galectin 3 / Q000097:blood*; D037161:Galectins / Q000097:blood; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis
chemical_list: D037483:Galectin 1; D037501:Galectin 2; D037502:Galectin 3; D037161:Galectins; C445499:LGALS1 protein, human; C091991:LGALS8 protein, human; C105032:LGALS9 protein, human
keywords: Galectins; Hemodialysis; Kidney; Renal transplantation