title: Association between serum HbA1c levels and adenomatous polyps in patients with the type 2 diabetes mellitus.
abstract: OBJECTIVE
  This study aimed to determine whether serum hemoglobin A1c (HbA1c) levels are associated with colonic adenomatous polyps (APs) in patients with type 2 diabetes mellitus.
  
  
  METHODS
  Four hundred sixty-four patients (262 men and 202 women) with type 2 diabetes mellitus and colorectal adenomas admitted to the Central Hospital of Wuhan University from June 2003 to December 2011 were enrolled. The patients' average age was 66.4 (range 36-78) years. The patients were divided into poorly controlled (HbA1c<7.5%) and well-controlled (HbA1c≥7.5%) groups. Prevalence of diabetes, family history of diabetes and colorectal cancer, Body Mass Index, smoking and drinking history, and use of aspirin and exogenous insulin were recorded and compare.
  
  
  RESULTS
  Patients with poorly controlled diabetes had a significantly higher incidence of right-sided and more advanced APs. In addition, patients with poorly controlled disease were more likely to have positive history of smoking and use higher doses of insulin than well-controlled patients (P<0.05 for all comparisons). A multivariate analysis demonstrated that poorly-controlled diabetes independently predicted a more advanced lesion at the time of presentation, higher body mass index, and a use of higher doses of insulin.
  
  
  CONCLUSIONS
  Poor glycemic control in patients with the type 2 diabetes mellitus independently predicts higher tendency to develop APs and an increased risk of colorectal cancer.
authors.affiliation: Department of Gastroenterology Renmin Hospital of Wuhan University Wuhan, China - xhnk@163.com.
authors.forename: X
authors.initials: X
authors.lastname: Huang
authors.forename: Y
authors.initials: Y
authors.lastname: Fan
authors.forename: H
authors.initials: H
authors.lastname: Zhang
authors.forename: J
authors.initials: J
authors.lastname: Wu
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: H
authors.initials: H
authors.lastname: Luo
mesh_terms: D018256:Adenomatous Polyps / Q000097:blood* / Q000150:complications*; D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D012907:Smoking
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human