title: Determination of the exposure parameters that maximise the concentrations of the anaesthetic/sedative eugenol in rainbow trout (Oncorhynchus mykiss) skin-on fillet tissue.
abstract: Studies were conducted to determine the anaesthetic/sedative concentrations and durations that would maximise anaesthetic/sedative residue concentrations in rainbow trout (Oncorhynchus mykiss) skin-on fillet tissue. Rainbow trout (167-404 g) were exposed to 50 mg l(-1) AQUI-S(®) 20E (10% active ingredient, eugenol) in 17°C freshwater for durations up to 1440 min, 100 and 250 mg l(-1) AQUI-S(®) 20E for durations up to 240 min, and 500 and 1000 mg l(-1) AQUI-S(®) 20E for durations up to 90 min. Fish exposed to 100 mg l(-1) AQUI-S(®) 20E for durations of 30, 60, 120 and 240 min had the greatest eugenol concentrations in the fillet tissue, 50, 58, 54 and 62 µg g(-1), respectively. All other exposure concentrations and durations resulted in significantly lower eugenol concentrations, i.e. all < 39 µg g(-1).
authors.affiliation: a US Department of the Interior , United States Geological Survey, Upper Midwest Environmental Sciences Center , La Crosse , WI , USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Meinertz
authors.forename: S T
authors.initials: ST
authors.lastname: Porcher
authors.forename: J R
authors.initials: JR
authors.lastname: Smerud
authors.forename: M P
authors.initials: MP
authors.lastname: Gaikowski
mesh_terms: D000777:Anesthetics / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004350:Drug Residues / Q000032:analysis*; D005054:Eugenol / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D008460:Meat / Q000032:analysis*; D018482:Muscle, Skeletal / Q000737:chemistry / Q000378:metabolism; D017686:Oncorhynchus mykiss / Q000378:metabolism; D015203:Reproducibility of Results; D012867:Skin; D012997:Solvents / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D000777:Anesthetics; D012997:Solvents; D005054:Eugenol
keywords: drug residues; eugenol; fish anesthetic; fish sedative