title: Coagulation parameters in inflammatory bowel disease.
abstract: Thromboembolic events represent a major cause of morbidity and mortality in patients with inflammatory bowel disease and they may occur both at the gastrointestinal tract and at extraintestinal sites. This study aimed to examine the alterations in coagulation parameters involved at different steps of hemostasis in patients with Crohn's disease and ulcerative colitis, in comparison with healthy individuals. Fifty-one patients with inflammatory bowel disease and 26 healthy controls were included in this study. Plasma levels of PT, APTT, AT III, plasminogen, fibrinogen, D-dimer, factor V, factor VIII, protein C, protein S, and APCR were measured and factor V Leiden mutation was examined in both patients and controls. Two patients with ulcerative colitis had a history of previous thromboembolic event. Inflammatory bowel disease was associated with significantly higher levels of fibrinogen, PT, factor V, factor VIII, plasminogen and thrombocyte. Protein S, fibrinogen, plasminogen and thrombocyte levels were associated with disease activity, depending on the type of the disease (Crohn's disease or ulcerative colitis). The coagulation abnormalities detected in this study seems to be a secondary phenomena resulting from the disease process, which is more likely to be associated with a multitude of factors rather than a single abnormality.
authors.affiliation: Department of Gastroenterology, Lutfi Kirdar Kartal Research and Training Hospital Kartal, Istanbul, Turkey.
authors.forename: Can
authors.initials: C
authors.lastname: Dolapcioglu
authors.affiliation: Department of Gastroenterology, Sadi Konuk Bakirkoy Research and Training Hospital Bakirkoy, Istanbul, Turkey.
authors.forename: Aliye
authors.initials: A
authors.lastname: Soylu
authors.affiliation: Department of Gastroenterology, Kurtkoy Emsey Hospital Istanbul, Turkey.
authors.forename: Tulin
authors.initials: T
authors.lastname: Kendir
authors.affiliation: Department of Gastroenterology, Bezmialem University School of Medicine Istanbul, Turkey.
authors.forename: Ali Tuzun
authors.initials: AT
authors.lastname: Ince
authors.affiliation: Department of Pathology, Fatih Sultan Mehmet Research and Training Hospital Istanbul, Turkey.
authors.forename: Hatice
authors.initials: H
authors.lastname: Dolapcioglu
authors.affiliation: Department of Biostatistics, Istanbul University Cerrahpasa Medical School Istanbul, Turkey.
authors.forename: Sevim
authors.initials: S
authors.lastname: Purisa
authors.affiliation: Department of Gastroenterology, Goztepe Medical Park Hospital Istanbul, Turkey.
authors.forename: Cengiz
authors.initials: C
authors.lastname: Bolukbas
authors.affiliation: Department of Gastroenterology, Umraniye Research and Training Hospital Istanbul, Turkey.
authors.forename: Haci Mehmet
authors.initials: HM
authors.lastname: Sokmen
authors.affiliation: Department of Gastroenterology, Goztepe Medical Park Hospital Istanbul, Turkey.
authors.forename: Remzi
authors.initials: R
authors.lastname: Dalay
authors.affiliation: Department of Gastroenterology, Haydarpasa Numune Research and Training Hospital Istanbul, Turkey.
authors.forename: Oya
authors.initials: O
authors.lastname: Ovunc
keywords: Crohn’s disease; Inflammatory bowel disease (IBD); coagulation; ulcerative colitis