title: Distinct perfusion patterns in Alzheimer's disease, frontotemporal dementia and dementia with Lewy bodies.
abstract: OBJECTIVE
  To compare pseudo-continuous arterial spin-labelled (PCASL) magnetic resonance imaging (MRI) measured quantitative cerebral blood flow (CBF) of patients with frontotemporal dementia (FTD), dementia with Lewy Bodies (DLB), Alzheimer's disease (AD) and controls, in a region of interest (ROI) and voxel-wise fashion.
  
  
  METHODS
  We analysed whole-brain 3D fast-spin-echo PCASL images of 20 FTD patients, 14 DLB patients, 48 AD patients and 50 controls from the Amsterdam Dementia Cohort. Regional CBF patterns were compared using analyses of variance for repeated measures. Permutation tests were used for voxel-wise comparisons. Analyses were performed using uncorrected and partial volume corrected (PVC) maps. All analyses were corrected for age and sex.
  
  
  RESULTS
  There was an interaction between diagnosis and region (p < 0.001), implying differences in regional CBF changes between diagnostic groups. In AD patients, CBF was decreased in all supratentorial regions, most prominently so in the posterior regions. DLB patients showed lowest CBF values throughout the brain, but temporal CBF was preserved. Supratentorial PVC cortical CBF values were lowest in the frontal lobes in FTD patients, and in the temporal lobes in AD patients.
  
  
  CONCLUSIONS
  Patients with AD, FTD and DLB display distinct patterns of quantitative regional CBF changes. 3D-PCASL may provide additional value in the workup of dementia patients.
  
  
  CONCLUSIONS
  Patterns of regional CBF changes differ between AD, FTD and DLB patients. CBF is lower throughout the brain in DLB than AD and FTD. 3D-PCASL MRI is a potential non-invasive and easily accessible alternative to FDG-PET. 3D-PCASL MRI may be of additional value in the workup of dementia.
authors.affiliation: Department of Radiology and Nuclear Medicine, VU University Medical Center and Neuroscience Campus Amsterdam, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands, m.binnewijzend@ggzingeest.nl.
authors.forename: Maja A A
authors.initials: MA
authors.lastname: Binnewijzend
authors.forename: Joost P A
authors.initials: JP
authors.lastname: Kuijer
authors.forename: Wiesje M
authors.initials: WM
authors.lastname: van der Flier
authors.forename: Marije R
authors.initials: MR
authors.lastname: Benedictus
authors.forename: Christiane M
authors.initials: CM
authors.lastname: Möller
authors.forename: Yolande A L
authors.initials: YA
authors.lastname: Pijnenburg
authors.forename: Afina W
authors.initials: AW
authors.lastname: Lemstra
authors.forename: Niels D
authors.initials: ND
authors.lastname: Prins
authors.forename: Mike P
authors.initials: MP
authors.lastname: Wattjes
authors.forename: Bart N M
authors.initials: BN
authors.lastname: van Berckel
authors.forename: Philip
authors.initials: P
authors.lastname: Scheltens
authors.forename: Frederik
authors.initials: F
authors.lastname: Barkhof
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000503:physiopathology; D017352:Echo-Planar Imaging / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D005625:Frontal Lobe / Q000473:pathology; D057180:Frontotemporal Dementia / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D016631:Lewy Bodies / Q000473:pathology*; D020961:Lewy Body Disease / Q000175:diagnosis* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013702:Temporal Lobe / Q000473:pathology