title: Comparison of 3D ultrasound and magnetic resonance imaging for microwave ablation in the canine splenomegaly model.
abstract: OBJECTIVE
  Microwave ablation is used for the treatment of hypersplenism. Image guidance and ablation volume assessment is important to ensure that the ablation is successful. The accuracy of 3D ultrasound (US) and magnetic resonance imaging (MRI) in determining the parameters for microwave ablation were compared in a canine splenomegaly model.
  
  
  METHODS
  Microwave ablation of the spleen was performed on 13 dogs with congestive splenomegaly. Several combinations of power output and ablation time were used: 60 W for 300 s, 50 W for 360 s and 40 W for 450 s. The ablation zone volume was measured by 3D US and 3D MRI immediately after microwave ablation, and at 1, 2 and 8 weeks thereafter.
  
  
  RESULTS
  Compared with 3D MRI, the ablation zone reconstruction rate was lower with 3D US (92 vs. 100%). However, there was no significant difference was found in the ablation volume calculated soon after the treatment and 1 week and 2 months later.
  
  
  CONCLUSIONS
  3D US may be useful for quantifying the volume of microwave ablation zones in the spleens of experimental animals and appears promising as an alterative modality to MRI for clinical examinations.
authors.affiliation: Department of Interventional Ultrasound, Yuquan Hosiptal, Tsinghua University, No. 5 of Shijingshan Road, Shijingshan District, Beijing, 100049, China, jlslsyyx@163.com.
authors.forename: Lin
authors.initials: L
authors.lastname: Sheng
authors.forename: Jialiang
authors.initials: J
authors.lastname: Li
authors.forename: Jibing
authors.initials: J
authors.lastname: Chen
authors.forename: Ping
authors.initials: P
authors.lastname: Liang
authors.forename: Baowei
authors.initials: B
authors.lastname: Dong
mesh_terms: D000818:Animals; D017115:Catheter Ablation / Q000379:methods*; D004195:Disease Models, Animal; D004285:Dogs; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008872:Microwaves; D013163:Splenomegaly / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D018084:Ultrasonography, Interventional / Q000379:methods*