title: A case of metastatic angiosarcoma diagnosed by liquid-based preparation: peculiar cytoplasmic changes.
abstract: Angiosarcoma with predominantly epithelioid features is a rare soft tissue neoplasm and the interpretation of its cytopathologic findings may be difficult. We report a case of metastatic angiosarcoma with predominantly epithelioid features diagnosed by liquid-based cytology. The cytopathologic findings in this case differed from those of the conventional preparation and we found a clean background, no hyperchromatic nuclei and several cytoplasmic changes, including intracytoplasmic vacuoles with peculiar shapes, juxtanuclear condensation and perinuclear clearing. Identification of these changes using liquid-based cytology supplemented with immunochemistry may be helpful in reaching a correct cytopathologic diagnosis.
authors.affiliation: Department of Pathology, Kosin University College of Medicine, Busan, Korea.
authors.forename: Min Jung
authors.initials: MJ
authors.lastname: Jung
authors.affiliation: Department of Pathology, Kosin University College of Medicine, Busan, Korea.
authors.forename: Young Ok
authors.initials: YO
authors.lastname: Kim
keywords: Cytodiagnosis; Cytologic techniques; Diagnosis; Differential; Hemangiosarcoma; Liquid based preparation