title: Lichenoid drug reaction following influenza vaccination in an HIV-positive patient: a case report and literature review.
abstract: Lichenoid drug reactions to vaccinations are rare but well-documented events. The vast majority of these reported reactions have been triggered by Hepatitis B vaccination (HBV). We describe an impressive generalized lichenoid drug reaction following the influenza vaccination. A 46-year-old African-American woman with a history of treated human immunodeficiency virus (HIV) disease developed a diffuse, pruritic rash one day following vaccination against the influenza virus. Physical exam and histopathology were consistent with a lichenoid drug eruption. This is only the fifth reported case of lichenoid drug reaction, and only the second generalized case, following influenza vaccination. The patient's underlying HIV disease, known to be a risk factor for both cutaneous drug reactions and more severe manifestations of lichen planus, likely predisposed her to this generalized hypersensitivity phenomenon.
authors.forename: Emily W
authors.initials: EW
authors.lastname: de Golian
authors.forename: Christina B
authors.initials: CB
authors.lastname: Brennan
authors.forename: Loretta S
authors.initials: LS
authors.lastname: Davis
mesh_terms: D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000009:adverse effects*; D017512:Lichenoid Eruptions / Q000139:chemically induced* / Q000473:pathology; D008875:Middle Aged; D011537:Pruritus / Q000139:chemically induced; D012307:Risk Factors
chemical_list: D007252:Influenza Vaccines