title: Anti-Müllerian hormone in premenopausal women following treatment of uterine cervical cancer.
abstract: In this longitudinal study we prospectively enrolled 32 premenopausal women (ages 23-44 years) with stage I-III uterine cervical cancer undergoing surgery and/or chemoradiation. Serum levels of anti-Müllerian hormone, follicle-stimulating hormone and estradiol were examined at baseline and 1 year after treatment. As expected, serum anti-Müllerian hormone was undetectable after salpingo-oophorectomy or chemoradiation. After radical hysterectomy and pelvic lymphadenectomy with ovarian preservation serum anti-Müllerian hormone declined from a mean value of 2.0 ± 1.4 μg/L to 1.1 ± 0.8 μg/L (p = 0.01), representing a 45% reduction, whereas there was no significant change in serum levels of follicle-stimulating hormone and estradiol. This implies that ovarian function may be affected not only by castrating treatment but also by radical hysterectomy with ovarian preservation. The risk of premature menopause and the potential need of hormone replacement therapy among these women may be overlooked since they no longer menstruate.
authors.affiliation: Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.
authors.forename: Asa
authors.initials: A
authors.lastname: Hallqvist Everhov
authors.forename: Karin
authors.initials: K
authors.lastname: Bergmark
authors.forename: Karin E
authors.initials: KE
authors.lastname: Smedby
authors.forename: Angelica
authors.initials: A
authors.lastname: Lindén Hirschberg
authors.forename: Angelique
authors.initials: A
authors.lastname: Flöter Rådestad
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D000970:Antineoplastic Agents / Q000627:therapeutic use; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007044:Hysterectomy; D008137:Longitudinal Studies; D008875:Middle Aged; D011446:Prospective Studies; D058994:Salpingectomy; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000601:surgery
chemical_list: D000970:Antineoplastic Agents; D004958:Estradiol; D054304:Anti-Mullerian Hormone; D005640:Follicle Stimulating Hormone
keywords: Uterine cervical cancer; anti-Müllerian hormone; chemoradiation; estradiol; follicle-stimulating hormone; radical hysterectomy