title: Environmental enrichment mitigates the sex-specific effects of gestational inflammation on social engagement and the hypothalamic pituitary adrenal axis-feedback system.
abstract: Modest environmental enrichment (EE) is well recognized to protect and rescue the brain from the consequences of a variety of insults. Although animal models of maternal immune activation (MIA) are associated with several neurodevelopmental impairments in both the behavioral and cognitive functioning of offspring, the impact of EE in protecting or reversing these effects has not been fully evaluated. In the present study, female Sprague-Dawley rats were randomized into EE (pair-housed in a large multi-level cage with toys, tubes and ramps) or animal care control (ACC; pair-housed in standard cages) conditions. Each pair was bred, following assignment to their housing condition, and administered 100μg/kg of lipopolysaccharide (LPS) on gestational day 11. After birth, and until the end of the study, offspring were maintained in their respective housing conditions. EE protected against both the social and hypothalamic pituitary adrenal axis consequences of MIA in juvenile male rats, but surprisingly not against the spatial discrimination deficits or accompanying decrease in glutamate levels within the hippocampus (as measured via LCMS-MS). Based on these preliminary results, the mechanisms that underlie the sex-specific consequences that follow MIA appear to be dependent on environmental context. Together, this work highlights the importance of environmental complexity in the prevention of neurodevelopmental deficits following MIA.
authors.affiliation: School of Arts & Sciences, Health Psychology Program, MCPHS University (formerly Massachusetts College of Pharmacy & Health Sciences), Boston, MA 02115, United States.
authors.forename: E J
authors.initials: EJ
authors.lastname: Connors
authors.affiliation: School of Pharmacy, MCPHS University, Boston, MA 02115, United States.
authors.forename: A N
authors.initials: AN
authors.lastname: Shaik
authors.affiliation: School of Pharmacy, MCPHS University, Boston, MA 02115, United States.
authors.forename: M M
authors.initials: MM
authors.lastname: Migliore
authors.affiliation: School of Arts & Sciences, Health Psychology Program, MCPHS University (formerly Massachusetts College of Pharmacy & Health Sciences), Boston, MA 02115, United States. Electronic address: amanda.kentner@mcphs.edu.
authors.forename: A C
authors.initials: AC
authors.lastname: Kentner
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D004777:Environment; D005260:Female; D006799:Housing, Animal; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000276:immunology* / Q000503:physiopathology; D007249:Inflammation / Q000276:immunology* / Q000503:physiopathology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000276:immunology* / Q000503:physiopathology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000276:immunology* / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012727:Sex Characteristics; D012919:Social Behavior
chemical_list: D008070:Lipopolysaccharides
keywords: Corticosterone; Environmental enrichment; Gestational inflammation; Glucocorticoid receptor; Glutamate; Hippocampus; NR2B receptor subunit; Social interaction; Spatial discrimination