title: Hormonal prevention of breast cancer.
abstract: Breast cancer prevention can be provided by using SERMs or aromatase inhibitors depending on the ovarian status, with a global risk reduction of 50 to 60%. Prophylactic annexectomy offered to reduce ovarian risk in BRCA mutation carriers also lowers breast cancer risk by 50%. Main side effects include deep vein thrombosis for SERMs, hot flushes and joint pain (although less frequently than initially suspected) with aromatase inhibitors. Other strategies based on progesterone, insulin or prolactin signaling modulation may be offered in the future. Criteria for candidate selection remain to be established.
authors.affiliation: Service de gynécologie-obstétrique et médecine de la reproduction, hôpital Tenon, hôpitaux universitaires Paris Est, site Tenon, université Pierre-et-Marie-Curie, 4, rue de la Chine, 75020 Paris, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Thomin
authors.affiliation: Service de gynécologie-obstétrique, hôpitaux universitaires Paris Est, site Trousseau, 26, avenue du Docteur-Arnold-Netter, 75012 Paris, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Friszer
authors.affiliation: Réseau sein à risque, AP-HP, Inca, Paris, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Fajac
authors.affiliation: Service de gynécologie-obstétrique et médecine de la reproduction, hôpital Tenon, hôpitaux universitaires Paris Est, site Tenon, université Pierre-et-Marie-Curie, 4, rue de la Chine, 75020 Paris, France; Réseau sein à risque, AP-HP, Inca, Paris, France.
authors.forename: Émile
authors.initials: É
authors.lastname: Daraï
authors.affiliation: Service de gynécologie-obstétrique et médecine de la reproduction, hôpital Tenon, hôpitaux universitaires Paris Est, site Tenon, université Pierre-et-Marie-Curie, 4, rue de la Chine, 75020 Paris, France; Réseau sein à risque, AP-HP, Inca, Paris, France. Electronic address: nathalie.chabbert-buffet@tnn.aphp.fr.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Chabbert-Buffet
mesh_terms: D047072:Aromatase Inhibitors / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use*; D018771:Arthralgia / Q000139:chemically induced; D001943:Breast Neoplasms / Q000235:genetics / Q000517:prevention & control*; D003362:Cost-Benefit Analysis; D005260:Female; D005602:France; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D020022:Genetic Predisposition to Disease; D019584:Hot Flashes / Q000139:chemically induced; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D010052:Ovariectomy; D010919:Placebos; D065286:Prophylactic Surgical Procedures / Q000191:economics; D011446:Prospective Studies; D020845:Selective Estrogen Receptor Modulators / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use*; D020246:Venous Thrombosis / Q000139:chemically induced
chemical_list: D047072:Aromatase Inhibitors; D010919:Placebos; D020845:Selective Estrogen Receptor Modulators
keywords: Antihormones; Breast; Cancer; Cancer du sein; Inhibiteur de l’aromatase; Prevention; Prévention; SERM