title: [Two cases of intravascular lymphoma diagnosed by random liver biopsy].
abstract: The pathogenesis of intravascular lymphoma (IVL) remains inadequately understood. Furthermore, its prognosis remains extremely poor despite combination chemotherapy. Lymphoma cells and hemophagocytosing cells are commonly observed in the livers of IVL patients and less frequently in the bone marrow. We recently encountered an 83-year-old female and a 78-year-old female with IVL, both of whom presented with fever of unknown origin. Following examination, we decided to perform random liver biopsy for diagnostic purposes. The former patient died because of rapid tumor growth, while the latter achieved remission following treatment with a modified R-VNCOP-B (etoposide, mitoxantrone, cyclophosphamide, vincristine, prednisolone, and bleomycin plus rituximab) regimen. Considering the possibility of IVL is important when examining a patient presenting with fever of unknown origin. This report demonstrates that random liver biopsy represents a useful diagnostic strategy, particularly in patients with elevated liver enzyme levels.
authors.affiliation: Department of Gastroenterology and Hematology, Kishiwada City Hospital.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Hoshi
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Fujii
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Okuyama
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Noboru
authors.initials: N
authors.lastname: Kimura
authors.forename: Youichi
authors.initials: Y
authors.lastname: Mouri
authors.forename: Haruo
authors.initials: H
authors.lastname: Takaya
authors.forename: Kouzou
authors.initials: K
authors.lastname: Kajimura
mesh_terms: D000369:Aged, 80 and over; D001706:Biopsy / Q000379:methods*; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology*; D008223:Lymphoma / Q000188:drug therapy / Q000473:pathology*; D019043:Vascular Neoplasms / Q000188:drug therapy / Q000473:pathology*