title: Synthesis, chemical identification, antioxidant capacities and immunological evaluation studies of a novel silver(I) carbocysteine complex.
abstract: A new silver-carbocysteine (Ccy-Ag) complex [Ag2(Ccy)2(H2O)2] has been synthesized and characterized by using a combination of FTIR, Raman, molar conductivity, (1)H NMR, electronic spectra, thermal analyses, X-ray powder diffraction (XRD) and scanning electron microscopy (SEM). The infrared spectrum of Ccy-Ag complex in comparison with carbocysteine ligand prove that Ccy behaves as monobasic bidentate chelate to the silver metal ions via the deprotonated carboxylate O atom. The assessments of Ccy and its complexation with Ag(+) in treating COPD, evaluating immune activities through measuring IL-8, TGF-β1, VEGF and TNF-α, antioxidant activities of (Ccy-Ag) complex by measuring SOD, MDA and GPX and bronchial asthma were discussed.
authors.affiliation: Department of Chemistry, Faculty of Science, Taif University, 888 Taif, Saudi Arabia; Department of Chemistry, Faculty of Science, Zagazig University, 44519 Zagazig, Egypt. Electronic address: samyelmegharbel@yahoo.com.
authors.forename: Samy M
authors.initials: SM
authors.lastname: El-Megharbel
authors.affiliation: Department of Zoology, Faculty of Science, Zagazig University, Zagazig, Egypt.
authors.forename: Reham Z
authors.initials: RZ
authors.lastname: Hamza
authors.affiliation: Department of Chemistry, Faculty of Science, Taif University, 888 Taif, Saudi Arabia; Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt.
authors.forename: Moamen S
authors.initials: MS
authors.lastname: Refat
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002233:Carbocysteine / Q000737:chemistry* / Q000494:pharmacology*; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000494:pharmacology; D016209:Interleukin-8 / Q000378:metabolism; D008168:Lung / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008855:Microscopy, Electron, Scanning; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D012834:Silver / Q000737:chemistry* / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000975:Antioxidants; D056831:Coordination Complexes; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D012834:Silver; D002233:Carbocysteine
keywords: Carbocysteine; Complex; Immunity; Nano-structure; Oxidative stress; Silver