title: Cytological features of pure micropapillary carcinoma of various organs: A report of eight cases.
abstract: Micropapillary carcinoma (MPC) is a rare aggressive tumor, which generally accompanies the primary carcinoma of the organ of its origin, while the pure form is extremely uncommon. Angiolymphatic involvement is widespread and a considerable proportion of the cases present with metastases. The current study presents eight pure MPC cases arising from the breast (n=3), urinary bladder (n=3), parotid gland (n=1) and lung (n=1, presenting with pericardial effusion), with the cytological findings. The eight patients included three female and five male cases aged between 48 and 74 years. The most common cytological findings were three-dimensional aggregates, cell clusters with angulated or scalloped borders, single cells with a columnar configuration and eccentric nuclei, and high-grade nuclear features. Histopathological sections showed accompanyingin situductal carcinoma in the cases of MPC arising in the parotid gland and breast (n=3), and one case in the bladder exhibited onlyin situMPC. The average follow-up period was 20 months (range, 6-54 months) and, during this period, three patients succumbed to the disease. At present, four patients are alive with disease and one patient is alive and disease-free. In conclusion, cytology is an important tool for the diagnosis and management of MPC.
authors.affiliation: Department of Pathology, Istanbul Education and Research Hospital, Istanbul 34098, Turkey.
authors.forename: Gülben Erdem
authors.initials: GE
authors.lastname: Huq
authors.affiliation: Department of Pathology, Istanbul University, Cerrahpasa Medical Faculty Istanbul 34320, Turkey.
authors.forename: Sule
authors.initials: S
authors.lastname: Canberk
authors.affiliation: Department of Pathology, Namık Kemal University Medical Faculty, Tekirdağ 59100, Turkey.
authors.forename: Meltem
authors.initials: M
authors.lastname: Oznur
authors.affiliation: Department of Pathology, Bezmialem University, Medical Faculty, Istanbul 34093, Turkey.
authors.forename: Pelin
authors.initials: P
authors.lastname: Yildiz
authors.affiliation: Department of Pathology, Bülent Ecevit University, Zonguldak 67100, Turkey.
authors.forename: Burak
authors.initials: B
authors.lastname: Bahadir
authors.affiliation: Department of Pathology, Istanbul Education and Research Hospital, Istanbul 34098, Turkey.
authors.forename: Kemal
authors.initials: K
authors.lastname: Behzatoğlu
keywords: breast; cytology; lung; micropapillary carcinoma; parotid; urinary bladder