title: A mitochondrial expatriate: nuclear pyruvate dehydrogenase.
abstract: The pyruvate dehydrogenase complex (PDC) catalyzes the conversion of pyruvate into acetyl-CoA, a critical step in metabolism. Sutendra et al. now demonstrate that PDC can translocate from the mitochondria to the nucleus to provide acetyl-CoA necessary for histone acetylation, suggesting a new pathway for mitochondrial-nuclear communication.
authors.affiliation: Department of Clinical Chemistry, Laboratory Genetic Metabolic Diseases, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands; Department of Pediatrics, Emma Children's Hospital, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands. Electronic address: v.c.deboer@amc.uva.nl.
authors.forename: Vincent C J
authors.initials: VC
authors.lastname: de Boer
authors.affiliation: Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: sander.houten@mssm.edu.
authors.forename: Sander M
authors.initials: SM
authors.lastname: Houten
mesh_terms: D000105:Acetyl Coenzyme A / Q000096:biosynthesis*; D002467:Cell Nucleus / Q000378:metabolism*; D006801:Humans; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism*
chemical_list: D011768:Pyruvate Dehydrogenase Complex; D000105:Acetyl Coenzyme A