title: Outbreak of Pneumocystis jirovecii pneumonia in renal transplant recipients on prophylaxis: our observation and experience.
abstract: Pneumocystis jirovecii is a life-threatening opportunistic pathogen affecting immunocompromised hosts, especially renal transplant recipients. This study reports an outbreak of seven such cases, both inpatients and outpatients, occurring in our hospital over a period of 4 months (January-April 2013). All patients were male with a median age of 38 years (range, 28-58 years); the median period between transplantation and diagnosis was 39.5 months (range, 11-123 months). One patient succumbed to the infection. Two were breakthrough cases, developing the infection while on prophylaxis, highlighting the need to view prophylaxis in light of the immunosuppression and clinical picture of such patients.
authors.affiliation: Department of Microbiology, Army Hospital Research and Referral, New Delhi, India.
authors.forename: P
authors.initials: P
authors.lastname: Chandola
authors.forename: M
authors.initials: M
authors.lastname: Lall
authors.forename: S
authors.initials: S
authors.lastname: Sen
authors.forename: R
authors.initials: R
authors.lastname: Bharadwaj
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D018890:Chemoprevention / Q000379:methods*; D004196:Disease Outbreaks; D006801:Humans; D016867:Immunocompromised Host; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D045363:Pneumocystis carinii / Q000302:isolation & purification*; D011020:Pneumonia, Pneumocystis / Q000453:epidemiology* / Q000401:mortality
chemical_list: D000935:Antifungal Agents