title: GTPases Rho distribution in intraepithelial and invasive neoplasias of the uterine cervix.
abstract: OBJECTIVE
  To evaluate the distribution of GTPases RhoA, RhoB, and Cdc42 in cervical intraepithelial neoplasias (CIN) and invasive neoplasias of the uterine cervix.
  
  
  METHODS
  samples of neoplastic lesions of the uterine cervix of 44 patients were classified in: CIN I (n = 10), CIN II (n = 10), CIN III (n = 09), and invasive carcinoma (n = 15). Antibodies anti-RhoA, anti-RhoB, and anti-Cdc42 were used and staining was classified as: negative, mild, moderate, and intense positive.
  
  
  RESULTS
  When compared with dysplastic cells, superficial cells showed: higher expression of RhoB in CIN I (p = 0.0018), and lower expression of Cdc42 in CIN I (p = 0.0225). The authors observed higher expression of RhoA (p = 0.0002) and RhoB (p = 0.0046) in CIN dysplastic cells when compared with invasive carcinoma cells.
  
  
  CONCLUSIONS
  GTPases Rho may be involved with the regulation of biological processes, important to the progression of cervical neoplasias. Probably, RhoA is important for maintenance of cell differentiation and RhoB protects cells from malignant cervical neoplasia.
authors.forename: M Gomes Salles
authors.initials: MG
authors.lastname: Tibúrcio
authors.forename: N M
authors.initials: NM
authors.lastname: Pinheiro
authors.forename: S de Sales Costa Moreira
authors.initials: Sde S
authors.lastname: Carboni
authors.forename: L P
authors.initials: LP
authors.lastname: Rocha
authors.forename: S J
authors.initials: SJ
authors.lastname: Adad
authors.forename: P J
authors.initials: PJ
authors.lastname: Maluf
authors.forename: E F Cândido
authors.initials: EF
authors.lastname: Murta
authors.forename: V O
authors.initials: VO
authors.lastname: Crema
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D002583:Uterine Cervical Neoplasms / Q000201:enzymology / Q000473:pathology*; D020764:cdc42 GTP-Binding Protein / Q000032:analysis; D020742:rhoA GTP-Binding Protein / Q000032:analysis / Q000502:physiology*; D020743:rhoB GTP-Binding Protein / Q000032:analysis / Q000502:physiology*; D002578:Uterine Cervical Dysplasia / Q000201:enzymology / Q000473:pathology*
chemical_list: D020764:cdc42 GTP-Binding Protein; D020742:rhoA GTP-Binding Protein; D020743:rhoB GTP-Binding Protein