title: Pyramidal lobe decreases endogenous TSH stimulation without impact on radio-iodine therapy outcome in patients with differentiated thyroid cancer.
abstract: OBJECTIVE
  The aim of the study was to assess the frequency of pyramidal lobe (PL) detected in iodine-131 (I-131) scans of thyroid bed in patients after thyroidectomy for differentiated thyroid cancer (DTC) and to investigate influence of PL on endogenous thyrotropin (TSH) stimulation as well as on the effects of the radio-iodine ablation in one-year follow-up.
  
  
  METHODS
  This study was designed as a retrospective analysis of 302 radio-iodine neck scans of patients thyroidectomized due to DTC. The study population was selected from patients with PL detected in thyroid bed scintigraphy. Patients without PL were included to the control group. The study and the control groups did not differ in age, sex of patients, histological type and stage of the DTC.
  
  
  RESULTS
  Pyramidal lobes were found in 30.5% of all patients. Patients in the study group underwent repeat surgery more often than controls without PL. Preablative TSH level in patients with PL was statistically lower than in the control group, in contrast to free thyroid hormones, which were higher in patients with PL. Preablative and postablative TSH-stimulated thyroglobulin (Tg) and antibodies against thyroglobulin (TgAbs) were measured in both groups, and comparison did not reveal differences. Moreover, for the per-patient analysis, sites of uptake in whole body scintigraphy performed 1 year after radio-iodine remnant ablation (RRA) did not differ between the study and the control groups.
  
  
  CONCLUSIONS
  Pyramidal lobe decreases endogenous TSH stimulation without impact on radio-iodine therapy outcome in patients with DTC.
authors.affiliation: Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49, Przybyszewskiego Street, 60355 Poznan, Poland. Electronic address: nyha@tlen.pl.
authors.forename: Nadia
authors.initials: N
authors.lastname: Sawicka-Gutaj
authors.affiliation: Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49, Przybyszewskiego Street, 60355 Poznan, Poland. Electronic address: oklim@wp.pl.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Klimowicz
authors.affiliation: Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49, Przybyszewskiego Street, 60355 Poznan, Poland. Electronic address: jsowin@ump.edu.pl.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Sowinski
authors.affiliation: Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49, Przybyszewskiego Street, 60355 Poznan, Poland. Electronic address: roleksa@ump.edu.pl.
authors.forename: Robert
authors.initials: R
authors.lastname: Oleksa
authors.affiliation: Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49, Przybyszewskiego Street, 60355 Poznan, Poland. Electronic address: mgryczyn@ump.edu.pl.
authors.forename: Maria
authors.initials: M
authors.lastname: Gryczynska
authors.affiliation: Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49, Przybyszewskiego Street, 60355 Poznan, Poland. Electronic address: andzin@amp.edu.pl.
authors.forename: Anna
authors.initials: A
authors.lastname: Wyszomirska
authors.affiliation: Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49, Przybyszewskiego Street, 60355 Poznan, Poland. Electronic address: agata.rat@wp.pl.
authors.forename: Agata
authors.initials: A
authors.lastname: Czarnywojtek
authors.affiliation: Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49, Przybyszewskiego Street, 60355 Poznan, Poland. Electronic address: mruchala@ump.edu.pl.
authors.forename: Marek
authors.initials: M
authors.lastname: Ruchala
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D013954:Thyroglobulin / Q000276:immunology / Q000378:metabolism; D013961:Thyroid Gland / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D013965:Thyroidectomy; D013972:Thyrotropin / Q000097:blood / Q000494:pharmacology / Q000502:physiology*; D016896:Treatment Outcome
chemical_list: D001323:Autoantibodies; D007457:Iodine Radioisotopes; D013972:Thyrotropin; D013954:Thyroglobulin
keywords: Cancer de la thyroïde; Cancer of thyroid; Glande thyroïde; Lobe pyramidal; Pyramidal lobe; Scintigraphie; Scintigraphy; Thyroid gland; Thyroidectomy; Thyroïdectomie