title: [Expression and role of IL-17 in nasal polyposis].
abstract: OBJECTIVE
  To study the expression of interleukin-17 (IL-17) in nasal polyps from both atopic and nonatopic patients, and its associations with histological features of polyps tissue.
  
  
  METHODS
  Thirty patients with nasal polyps (NP) were included and divided into atopic and nonatopic groups according to the skin prick test. Histological characteristics were assessed by eosinophilic infiltration with HE staining. IL-17 expression in polyps tissue was detected by ELISA and RT-PCR.
  
  
  RESULTS
  Eosinophilic infiltration was significantly higher in atopic NP patients than in nonatopic NP patients (P < 0.01). IL-17 protein and IL-17 mRNA levels were significantly upregulated in both atopic (P < 0.01) and nonatopic (P < 0.05) patients compared with controls. Furthermore, IL-17 levels were significantly higher in the atopic group than in nonatopic group. Significantly positive correlations were found between IL-17 levels and eosinophilic infiltration in NP patients.
  
  
  CONCLUSIONS
  These results indicated that expression of IL-17 was significantly upregulated in NP patients and was especially higher in atopic NP patients, suggesting that IL-17 may play an important role in the pathogenesis of NP and atopy may contribute to NP by stimulating the production of IL-17.
authors.forename: Yang
authors.initials: Y
authors.lastname: Shen
authors.forename: Suling
authors.initials: S
authors.lastname: Hong
authors.forename: Guohua
authors.initials: G
authors.lastname: Hu
mesh_terms: D000328:Adult; D000368:Aged; D004804:Eosinophils / Q000166:cytology; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000378:metabolism / Q000473:pathology; D020381:Interleukin-17 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000378:metabolism* / Q000473:pathology; D055815:Young Adult
chemical_list: D020381:Interleukin-17