title: Role of 99mTc-ECD SPECT in the management of children with craniosynostosis.
abstract: OBJECTIVE
  There is a paucity of data on correlation of various imaging modalities with clinical findings in craniosynostosis. Moreover, no study has specifically reported the role of (99m)Tc-ECD SPECT in a large number of subjects with craniosynostosis.
  
  
  METHODS
  We prospectively analyzed a cohort of 85 patients with craniosynostosis from year 2007 to 2012. All patients underwent evaluation with (99m)Tc-ECD SPECT and the results were correlated with radiological and surgical findings.
  
  
  RESULTS
  (99m)Tc-ECD SPECT revealed regional perfusion abnormalities in the cerebral hemisphere corresponding to the fused sutures preoperatively that disappeared postoperatively in all the cases. Corresponding to this, the mean mental performance quotient (MPQ) increased significantly (P < 0.05) postoperatively only in those children with absent perfusion defect postoperatively.
  
  
  CONCLUSIONS
  Our study suggests that early surgery and release of craniosynostosis in patients with preoperative perfusion defects (absent on (99m)Tc-ECD SPECT study) are beneficial, as they lead to improved MPQ after surgery.
authors.affiliation: Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Mayadhar
authors.initials: M
authors.lastname: Barik
authors.affiliation: Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Minu
authors.initials: M
authors.lastname: Bajpai
authors.affiliation: Department of Pediatrics, All India Institute of Medical Sciences, Bhubaneswar 751019, India.
authors.forename: Rashmi Ranajn
authors.initials: RR
authors.lastname: Das
authors.affiliation: Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Arun
authors.initials: A
authors.lastname: Malhotra
authors.affiliation: Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Shasanka Shekhar
authors.initials: SS
authors.lastname: Panda
authors.affiliation: Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Manas Kumar
authors.initials: MK
authors.lastname: Sahoo
authors.affiliation: Department of Biostatistics, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Sadanand
authors.initials: S
authors.lastname: Dwivedi
mesh_terms: D002675:Child, Preschool; D003398:Craniosynostoses / Q000000981:diagnostic imaging* / Q000601:surgery*; D003545:Cysteine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D015609:Organotechnetium Compounds / Q000008:administration & dosage*; D011859:Radiography; D019275:Radiopharmaceuticals / Q000008:administration & dosage*; D012189:Retrospective Studies; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C059659:technetium Tc 99m bicisate; D003545:Cysteine