title: Mathematical models in drug delivery: how modeling has shaped the way we design new drug delivery systems.
abstract: In this review we present some of the seminal contributions that have established the mathematical foundations of controlled drug delivery and led to the modern models. Mathematical modeling is no longer just a dry exercise in generating more and more complex models or a parametric fitting process, but rather an advanced analysis that can lead to a priori examination of a release/delivery process or a series of design equations that help the practitioner achieve a better formulation.
authors.affiliation: Department of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712, USA; Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA; College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA.
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Peppas
authors.affiliation: Department of Chemical and Biological Engineering, Iowa State University, Ames, IA 50011, USA.
authors.forename: Balaji
authors.initials: B
authors.lastname: Narasimhan
mesh_terms: D003692:Delayed-Action Preparations / Q000493:pharmacokinetics*; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D008962:Models, Theoretical
chemical_list: D003692:Delayed-Action Preparations
keywords: Controlled release; Diffusion; Dissolution; Erosion; Mathematical modeling; Swelling