title: Application of EPR dosimetry in bone for ex vivo measurements of doses in radiotherapy patients.
abstract: In the present study, bone samples from three patients treated in radiotherapy facilities in Poland were used for the determination of doses absorbed during radiotherapy. The samples were obtained during surgical treatments of patients performed due to medical indications. For the purpose of retrospective dosimetry, sensitivity of the radiation-induced EPR signal was individually calibrated in the samples by re-irradiation of the samples with known doses. The doses reconstructed in bones extracted within 6 months after irradiation were consistent with those calculated by treatment planning systems. The dose reconstructed in the bone removed 6 y after radiotherapy was ∼14% lower than the calculated one.
authors.affiliation: Department of Physics and Biophysics, Medical University of Gdansk, Debinki 1, Gdansk 80-211, Poland kkrefft@gumed.edu.pl.
authors.forename: K
authors.initials: K
authors.lastname: Krefft
authors.affiliation: Department of Oral and Maxillofacial Surgery, University Clinical Center in Gdansk, Debinki 7, Gdansk 80-952, Poland.
authors.forename: B
authors.initials: B
authors.lastname: Drogoszewska
authors.affiliation: Department of Oncology and Radiotherapy, University Clinical Center in Gdansk, Debinki 7, Gdansk 80-952, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Kaminska
authors.affiliation: Department of Physics and Biophysics, Medical University of Gdansk, Debinki 1, Gdansk 80-211, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Juniewicz
authors.affiliation: Hospital Ministry of Interior with Warmia-Mazury Cancer Center, Al. Wojska Polskiego 37, Olsztyn 10-228, Poland.
authors.forename: G
authors.initials: G
authors.lastname: Wołąkiewicz
authors.affiliation: Department of Medical Physics, Maritime Hospital of Gdynia, Powstania Styczniowego 1, Gdynia 81-519, Poland.
authors.forename: I
authors.initials: I
authors.lastname: Jakacka
authors.affiliation: Department of Physics and Biophysics, Medical University of Gdansk, Debinki 1, Gdansk 80-211, Poland.
authors.forename: B
authors.initials: B
authors.lastname: Ciesielski
mesh_terms: D001859:Bone Neoplasms / Q000532:radiotherapy* / Q000556:secondary; D001842:Bone and Bones / Q000528:radiation effects*; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods*; D006801:Humans; D008048:Lip Neoplasms / Q000473:pathology / Q000532:radiotherapy; D009062:Mouth Neoplasms / Q000473:pathology / Q000532:radiotherapy; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage