title: Central nervous system infection caused by vancomycin-intermediate Staphylococcus aureus (SCCmec type IV, ST8).
abstract: A 77-year-old Japanese man with a history of surgical treatment of chronic subdural hemorrhage was hospitalized for drainage of a subdural abscess and brain abscess in the right occipital area. Pus obtained from both the subdural abscess and brain abscess grew vancomycin-intermediate Staphylococcus aureus (VISA) (minimum inhibitory concentration = 4 μg/mL), which was confirmed by population analysis. The SCCmec type and sequence type were subsequently identified as IV and ST8, respectively. The VISA strains were both sensitive to levofloxacin, clindamycin, minocycline, and linezolid. The patient was successfully treated with linezolid and discharged on day 51 after admission. We herein describe the first reported case of a brain abscess and subdural abscess caused by VISA in Japan.
authors.affiliation: Department of Neurosurgery, Tsukuba Medical Center Hospital, Ibaraki, Japan.
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Kino
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Tsukuba Medical Center Hospital, Ibaraki, Japan. Electronic address: hsuzuki@tmch.or.jp.
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Suzuki
authors.affiliation: Department of Microbiology, Tokyo Medical University, Tokyo, Japan.
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Yamaguchi
authors.affiliation: Department of Clinical Microbiology, Miroku Medical Laboratory Inc., Nagano, Japan.
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Notake
authors.affiliation: Department of Infectious Diseases, Ibaraki Medical Center, Tokyo Medical University, Tokyo, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Oishi
authors.affiliation: Department of Neurosurgery, Tsukuba Medical Center Hospital, Ibaraki, Japan.
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Ito
authors.affiliation: Department of Neurosurgery, Tsukuba Medical Center Hospital, Ibaraki, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nakamura
authors.affiliation: Department of Microbiology, Tokyo Medical University, Tokyo, Japan.
authors.forename: Haruko
authors.initials: H
authors.lastname: Miyazaki
authors.affiliation: Department of Microbiology, Tokyo Medical University, Tokyo, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Matsumoto
authors.affiliation: Department of Neurosurgery, Tsukuba Medical Center Hospital, Ibaraki, Japan.
authors.forename: Kazuya
authors.initials: K
authors.lastname: Uemura
authors.affiliation: Department of Neurosurgery, University of Tsukuba Hospital, Ibaraki, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Matsumura
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002494:Central Nervous System Infections / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D008297:Male; D013203:Staphylococcal Infections / Q000150:complications* / Q000188:drug therapy; D013211:Staphylococcus aureus / Q000145:classification* / Q000187:drug effects; D020713:Vancomycin Resistance
chemical_list: D000900:Anti-Bacterial Agents
keywords: Brain abscess; Subdural abscess; Vancomycin-intermediate Staphylococcus aureus