title: A recycling model of the biokinetics of systemic tellurium.
abstract: OBJECTIVE
  To develop a compartmental model of the systemic biokinetics of tellurium required for calculating the internal dose and interpreting bioassay measurements after incorporation of radioactive tellurium.
  
  
  METHODS
  The compartmental model for tellurium was developed with the software SAAM II v. 2.0 (©The Epsilon Group, Charlottesville, Virginia, USA). Model parameters were determined on the basis of published retention and excretion data in humans and animals.
  
  
  RESULTS
  The model consists of two blood compartments, one compartment each for liver, kidneys, thyroid, four compartments for bone tissues and a generic compartment for the soft tissues. The model predicts a rapid urinary excretion of systemic tellurium: 45% in the first 24 h and 84% after 50 d. Faecal excretion amounts to 0.4% after 3 d and 9% after 50 d. Whole body retention is 55% after one day, and 2.8% after 100 d. These values as well as the retained fractions in the single organs are reasonably consistent with the available human and animal data (studies with swine and guinea pigs).
  
  
  CONCLUSIONS
  The proposed model gives a realistic description of the available biokinetic data for tellurium and will be adopted by the International Commission on Radiological Protection for applications in internal dosimetry.
authors.affiliation: BfS Bundesamt für Strahlenschutz/Federal Office for Radiation Protection, Department of Radiation and Health , Oberschleißheim , Germany.
authors.forename: Augusto
authors.initials: A
authors.lastname: Giussani
mesh_terms: D000818:Animals; D001681:Biological Assay; D001842:Bone and Bones / Q000528:radiation effects; D006168:Guinea Pigs; D006801:Humans; D007668:Kidney / Q000528:radiation effects; D007700:Kinetics; D008099:Liver / Q000528:radiation effects; D008962:Models, Theoretical; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods; D012984:Software; D013552:Swine; D013691:Tellurium / Q000737:chemistry*; D013961:Thyroid Gland / Q000528:radiation effects; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D013691:Tellurium
keywords: Tellurium; compartmental models; internal dosimetry; systemic biokinetics