title: DOR - a Database of Olfactory Receptors - Integrated Repository for Sequence and Secondary Structural Information of Olfactory Receptors in Selected Eukaryotic Genomes.
abstract: Olfaction is the response to odors and is mediated by a class of membrane-bound proteins called olfactory receptors (ORs). An understanding of these receptors serves as a good model for basic signal transduction mechanisms and also provides important clues for the strategies adopted by organisms for their ultimate survival using chemosensory perception in search of food or defense against predators. Prior research on cross-genome phylogenetic analyses from our group motivated the addressal of conserved evolutionary trends, clustering, and ortholog prediction of ORs. The database of olfactory receptors (DOR) is a repository that provides sequence and structural information on ORs of selected organisms (such as Saccharomyces cerevisiae, Drosophila melanogaster, Caenorhabditis elegans, Mus musculus, and Homo sapiens). Users can download OR sequences, study predicted membrane topology, and obtain cross-genome sequence alignments and phylogeny, including three-dimensional (3D) structural models of 100 selected ORs and their predicted dimer interfaces. The database can be accessed from http://caps.ncbs.res.in/DOR. Such a database should be helpful in designing experiments on point mutations to probe into the possible dimerization modes of ORs and to even understand the evolutionary changes between different receptors.
authors.affiliation: National Center for Biological Sciences (TIFR), Bangalore, India.
authors.forename: Balasubramanian
authors.initials: B
authors.lastname: Nagarathnam
authors.affiliation: National Center for Biological Sciences (TIFR), Bangalore, India.
authors.forename: Snehal D
authors.initials: SD
authors.lastname: Karpe
authors.affiliation: National Center for Biological Sciences (TIFR), Bangalore, India.
authors.forename: Krishnan
authors.initials: K
authors.lastname: Harini
authors.affiliation: Birla Institute of Technology and Science, Pilani, India. ; Presently in: Bioinformatics and Computational Biology Program, Iowa State University, Ames, IA, USA.
authors.forename: Kannan
authors.initials: K
authors.lastname: Sankar
authors.affiliation: National Center for Biological Sciences (TIFR), Bangalore, India.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Iftekhar
authors.affiliation: Department of Animal Sciences, Bharathidasan University, Tiruchirapalli, Tamil Nadu, India.
authors.forename: Durairaj
authors.initials: D
authors.lastname: Rajesh
authors.affiliation: National Center for Biological Sciences (TIFR), Bangalore, India.
authors.forename: Sadasivam
authors.initials: S
authors.lastname: Giji
authors.affiliation: Department of Animal Sciences, Bharathidasan University, Tiruchirapalli, Tamil Nadu, India.
authors.forename: Govidaraju
authors.initials: G
authors.lastname: Archunan
authors.affiliation: Department of Biotechnology, K.S. Rangasamy College of Technology, Tiruchengode, Tamil Nadu, India.
authors.forename: Veluchamy
authors.initials: V
authors.lastname: Balakrishnan
authors.affiliation: Department of Biotechnology, Indian Institute of Technology Madras, Chennai, Tamil Nadu, India.
authors.forename: M Michael
authors.initials: MM
authors.lastname: Gromiha
authors.affiliation: Current Address: Division of Life Science and Engineering, School of Science and Engineering, Tokyo Denki University, Ishizaka, Hatoyama-cho, Hiki-gun, Saitama, 350-0394, Japan.
authors.forename: Wataru
authors.initials: W
authors.lastname: Nemoto
authors.affiliation: Molecular Profiling Research Center for Drug Discover, National Institute of Advanced Industrial Science and Technology, Aomi, Koto-ku,Tokyo, Japan.
authors.forename: Kazhuhiko
authors.initials: K
authors.lastname: Fukui
authors.affiliation: National Center for Biological Sciences (TIFR), Bangalore, India.
authors.forename: Ramanathan
authors.initials: R
authors.lastname: Sowdhamini
keywords: insect olfactory system; membrane proteins; odor perception; olfaction