title: Molecular investigations of the brain of higher mammals using gyrencephalic carnivore ferrets.
abstract: The brains of mammals such as carnivores and primates contain developed structures not found in the brains of mice. Uncovering the physiological importance, developmental mechanisms and evolution of these structures using carnivores and primates would greatly contribute to our understanding of the human brain and its diseases. Although the anatomical and physiological properties of the brains of carnivores and primates have been intensively examined, molecular investigations are still limited. Recently, genetic techniques that can be applied to carnivores and primates have been explored, and molecules whose expression patterns correspond to these structures were reported. Furthermore, to investigate the functional importance of these molecules, rapid and efficient genetic manipulation methods were established by applying electroporation to gyrencephalic carnivore ferrets. In this article, I review recent advances in molecular investigations of the brains of carnivores and primates, mainly focusing on ferrets (Mustela putorius furo).
authors.affiliation: Graduate School of Medical Sciences, Kanazawa University, Ishikawa 920-8640, Japan; Brain/Liver Interface Medicine Research Center, Kanazawa University, Ishikawa 920-8640, Japan. Electronic address: hiroshi-kawasaki@umin.ac.jp.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawasaki
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D005075:Biological Evolution; D001921:Brain / Q000033:anatomy & histology* / Q000502:physiology*; D018274:Electroporation; D005289:Ferrets / Q000033:anatomy & histology; D006801:Humans; D008322:Mammals; D008967:Molecular Biology; D014795:Visual Pathways / Q000502:physiology
keywords: Ferret; Gyrus; In utero electroporation; OSVZ; Parallel visual pathways