title: Salmonella as a biological "Trojan horse" for neoplasia: future possibilities including brain cancer.
abstract: This manuscript considers available evidence that a specific Salmonella strain could be used as an effective orally-administered option for cancer therapy involving the brain. It has been established that Salmonella preferentially colonizes neoplastic tissue and thrives as a facultative anaerobe in the intra-tumor environment. Although Salmonella accumulates in tumors by passive processes, it is still possible for lipopolysaccharide to cause sepsis and endotoxic shock during the migration of bacteria to the tumor site. An LPS-free version of a recently identified Salmonella isolate may have the capability to circumvent the blood brain barrier and provide a safer method of reaching brain tumors. This isolate merits further research as a "Trojan horse" for future oral biotherapy of brain cancer.
authors.affiliation: Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA 50011, United States.
authors.forename: Gregory S A
authors.initials: GS
authors.lastname: Mlynarczyk
authors.affiliation: Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA 50011, United States.
authors.forename: Carrie A
authors.initials: CA
authors.lastname: Berg
authors.affiliation: Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA 50011, United States.
authors.forename: Isabelle C
authors.initials: IC
authors.lastname: Withrock
authors.affiliation: Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA 50011, United States.
authors.forename: Meghan E
authors.initials: ME
authors.lastname: Fick
authors.affiliation: Department of Psychology, Iowa State University College of Liberal Arts and Sciences, Ames, IA 50011, United States.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Anderson
authors.affiliation: Department of Genetics, Development, and Cell Biology, Iowa State University College of Agriculture and Life Science, Ames, IA 50011, United States.
authors.forename: Lauren A
authors.initials: LA
authors.lastname: Laboissonniere
authors.affiliation: Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA 50011, United States.
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Jefferson
authors.affiliation: Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA 50011, United States.
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Brewer
authors.affiliation: Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA 50011, United States.
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Stock
authors.affiliation: Department of Kinesiology, Iowa State University College of Human Sciences, Ames, IA 50011, United States.
authors.forename: Jennifer K
authors.initials: JK
authors.lastname: Lange
authors.affiliation: Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA 50011, United States.
authors.forename: K C
authors.initials: KC
authors.lastname: Luna
authors.affiliation: Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA 50011, United States.
authors.forename: Sreemoyee
authors.initials: S
authors.lastname: Acharya
authors.affiliation: Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA 50011, United States.
authors.forename: Sriharsha
authors.initials: S
authors.lastname: Kanuri
authors.affiliation: Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA 50011, United States.
authors.forename: Shaunik
authors.initials: S
authors.lastname: Sharma
authors.affiliation: Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA 50011, United States.
authors.forename: Naveen C
authors.initials: NC
authors.lastname: Kondru
authors.affiliation: Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA 50011, United States.
authors.forename: Garrett R
authors.initials: GR
authors.lastname: McCormack
authors.affiliation: Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA 50011, United States. Electronic address: stevec@iastate.edu.
authors.forename: Steve A
authors.initials: SA
authors.lastname: Carlson
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D001812:Blood-Brain Barrier; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000150:complications / Q000382:microbiology* / Q000628:therapy; D002417:Cattle; D004195:Disease Models, Animal; D006801:Humans; D000860:Hypoxia; D008070:Lipopolysaccharides / Q000737:chemistry; D009154:Mutation; D009369:Neoplasms / Q000150:complications / Q000382:microbiology / Q000628:therapy; D012475:Salmonella / Q000502:physiology*; D018805:Sepsis / Q000503:physiopathology; D012772:Shock, Septic / Q000503:physiopathology; D013552:Swine
chemical_list: D000970:Antineoplastic Agents; D008070:Lipopolysaccharides