title: The potential of magneto-electric nanocarriers for drug delivery.
abstract: BACKGROUND
  The development and design of personalized nanomedicine for better health quality is receiving great attention. In order to deliver and release a therapeutic concentration at the target site, novel nanocarriers (NCs) were designed, for example, magneto-electric (ME) which possess ideal properties of high drug loading, site-specificity and precise on-demand controlled drug delivery.
  
  
  METHODS
  This review explores the potential of ME-NCs for on-demand and site-specific drug delivery and release for personalized therapeutics. The main features including effect of magnetism, improvement in drug loading, drug transport across blood-brain barriers and on-demand controlled release are also discussed. The future directions and possible impacts on upcoming nanomedicine are highlighted.
  
  
  CONCLUSIONS
  Numerous reports suggest that there is an urgent need to explore novel NC formulations for safe and targeted drug delivery and release at specific disease sites. The challenges of formulation lie in the development of NCs that improve biocompatibility and surface modifications for optimum drug loading/preservation/transmigration and tailoring of electrical-magnetic properties for on-demand drug release. Thus, the development of novel NCs is anticipated to overcome the problems of targeted delivery of therapeutic agents with desired precision that may lead to better patient compliance.
authors.affiliation: Florida International University, Institute of Neuroimmune Pharmacology, Herbert Wertheim College of Medicine, Center of Personalized Nanomedicine, Department of Immunology , Miami, FL-33199 , USA.
authors.forename: Ajeet
authors.initials: A
authors.lastname: Kaushik
authors.forename: Rahul Dev
authors.initials: RD
authors.lastname: Jayant
authors.forename: Vidya
authors.initials: V
authors.lastname: Sagar
authors.forename: Madhavan
authors.initials: M
authors.lastname: Nair
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers; D016503:Drug Delivery Systems; D055590:Electromagnetic Phenomena; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage
chemical_list: D004337:Drug Carriers; D004364:Pharmaceutical Preparations
keywords: drug delivery; magneto-electric nanocarriers; nanocarriers; therapeutic agent