title: Focus on desmopressin and enuresis: a review of literature.
abstract: Nocturnal enuresis (NE) is a common disorder in children. Choice of treatment depends on the frequency and severity of symptoms, the child's age and motivation. Treatment options for NE are alarm, desmopressin and imipramine. In particular, the main desmopressin therapeutical effect is the antidiuretic activity. The different formulations of desmopressin are an injectable solution, an oral tablet formulation and the recent oral lyophilisate (MELT). MELT with its higher biodisponibility guarantees the same therapy response of other formulations with a lower doses and it represents the first line and safety treatment for the NE.
authors.affiliation: Institute of Pediatrics, Sacro Cuore Catholic University, Rome, Italy - pferrara@rm.unicatt.it.
authors.forename: Pietro
authors.initials: P
authors.lastname: Ferrara
authors.forename: Flaminia
authors.initials: F
authors.lastname: Vena
authors.forename: Maria C
authors.initials: MC
authors.lastname: Basile
authors.forename: Francesca
authors.initials: F
authors.lastname: Ianniello
authors.forename: Antonio
authors.initials: A
authors.lastname: Gatto
mesh_terms: D000284:Administration, Oral; D050034:Antidiuretic Agents / Q000008:administration & dosage*; D002648:Child; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D053206:Nocturnal Enuresis / Q000188:drug therapy* / Q000453:epidemiology; D015995:Prevalence; D016896:Treatment Outcome
chemical_list: D050034:Antidiuretic Agents; D003894:Deamino Arginine Vasopressin