title: Cancer-targeted functional gold nanoparticles for apoptosis induction and real-time imaging based on FRET.
abstract: A versatile gold nanoparticle-based multifunctional RB-DEVD-AuNP-DTP has been developed to induce the targeted apoptosis of cancer cells and image in real time the progress of the apoptosis. The multifunctional nanoparticles were demonstrated to have the ability to initiate mitochondria-dependent apoptosis and activate caspase-3 for real-time imaging of the progression of apoptosis.
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China. xz-zhang@whu.edu.cn.
authors.forename: Wei-Hai
authors.initials: WH
authors.lastname: Chen
authors.forename: Guo-Feng
authors.initials: GF
authors.lastname: Luo
authors.forename: Xiao-Ding
authors.initials: XD
authors.lastname: Xu
authors.forename: Hui-Zhen
authors.initials: HZ
authors.lastname: Jia
authors.forename: Qi
authors.initials: Q
authors.lastname: Lei
authors.forename: Kai
authors.initials: K
authors.lastname: Han
authors.forename: Xian-Zheng
authors.initials: XZ
authors.lastname: Zhang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D004337:Drug Carriers / Q000737:chemistry* / Q000494:pharmacology; D031541:Fluorescence Resonance Energy Transfer; D006046:Gold / Q000737:chemistry* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D006046:Gold