title: Large dosage of chishao in formulae for cholestatic hepatitis: a systematic review and meta-analysis.
abstract: Objective. To evaluate the efficacy and safety of large dosage of Chishao in formulae for treatment of cholestatic hepatitis. Methods. The major databases (PubMed, Embase, Cochrane Library, Chinese Biomedical Database Wanfang, VIP medicine information system, and China National Knowledge Infrastructure) were searched until January 2014. Randomized controlled trials (RCTs) of large dosage of Chishao in formulae that reported on publications in treatment of cholestatic hepatitis with total efficacy rate, together with the biochemical indices including alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), and direct bilirubin (DBIL), were extracted by two reviewers. The Cochrane tool was used for the assessment of risk of bias included trials. Data were analyzed with RevMan 5.2.7 software. Results. 11 RCTs involving 1275 subjects with cholestatic hepatitis were included. Compared with essential therapy, large dosage of Chishao in formulae demonstrated more efficiently with down regulation of serum ALT, AST, TBIL, DBIL. Meanwhile, there were no obvious adverse events. Conclusion. As a promising novel treatment approach, widely using large dosage of Chishao in formulae may enhance the curative efficacy for cholestatic hepatitis. Considering being accepted by more and more practitioners, further rigorously designed clinical studies are required.
authors.affiliation: Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China ; China Military Institute of Chinese Medicine, 302 Hospital of People's Liberation Army, Beijing 100039, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Evidence-Based Medicine and Clinical Epidemiology, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: He
authors.affiliation: China Military Institute of Chinese Medicine, 302 Hospital of People's Liberation Army, Beijing 100039, China.
authors.forename: Yanling
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: China Military Institute of Chinese Medicine, 302 Hospital of People's Liberation Army, Beijing 100039, China.
authors.forename: Jiabo
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Integrative Medical Center, 302 Hospital of People's Liberation Army, Beijing 100039, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Integrative Medical Center, 302 Hospital of People's Liberation Army, Beijing 100039, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China ; China Military Institute of Chinese Medicine, 302 Hospital of People's Liberation Army, Beijing 100039, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhong
authors.affiliation: Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China ; China Military Institute of Chinese Medicine, 302 Hospital of People's Liberation Army, Beijing 100039, China.
authors.forename: Quanfu
authors.initials: Q
authors.lastname: Zheng
authors.affiliation: China Military Institute of Chinese Medicine, 302 Hospital of People's Liberation Army, Beijing 100039, China.
authors.forename: Xiaohe
authors.initials: X
authors.lastname: Xiao