title: Disseminated Mycobacterium celatum disease with prolonged pulmonary involvement.
abstract: Mycobacterium celatum is a rare cause of human infection, causing disseminated disease in immunosuppressed individuals. Infections localized to the lungs and the lymph nodes have also been reported in immunocompetent individuals. The existing literature on the subject is limited as are experiences with treatment regimens and durations. In the case presented herein, two different treatment regimens were applied to an immunocompromised HIV-negative patient with primary skin involvement and extensive pulmonary involvement due to suspected relapse on isoniazid, ethambutol, and clarithromycin treatment. The treatment regimen was changed to azithromycin, ciprofloxacin, and pyrazinamide and the treatment duration was prolonged to a total of 24 months, with good effect.
authors.affiliation: GloHAU, Center for Global Health, Department of Public Health, Aarhus University, Aarhus, Denmark; Department of Infectious Diseases, Aarhus University Hospital, Brendstrupgaardsvej 100, 8200 Aarhus N, Denmark. Electronic address: ceciliepatsche@live.dk.
authors.forename: Cecilie Blenstrup
authors.initials: CB
authors.lastname: Patsche
authors.affiliation: Mycobacteriology Laboratory, Statens Serum Institut, Copenhagen, Denmark.
authors.forename: Erik
authors.initials: E
authors.lastname: Svensson
authors.affiliation: GloHAU, Center for Global Health, Department of Public Health, Aarhus University, Aarhus, Denmark; Department of Infectious Diseases, Aarhus University Hospital, Brendstrupgaardsvej 100, 8200 Aarhus N, Denmark.
authors.forename: Christian
authors.initials: C
authors.lastname: Wejse
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D017963:Azithromycin / Q000627:therapeutic use; D002939:Ciprofloxacin / Q000627:therapeutic use; D017291:Clarithromycin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004977:Ethambutol / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008171:Lung Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D009161:Mycobacterium / Q000187:drug effects; D009164:Mycobacterium Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D011718:Pyrazinamide / Q000627:therapeutic use; D011859:Radiography
chemical_list: D000900:Anti-Bacterial Agents; D011718:Pyrazinamide; D002939:Ciprofloxacin; D017963:Azithromycin; D004977:Ethambutol; D017291:Clarithromycin; D007538:Isoniazid
keywords: Mycobacterium celatum; Non-tuberculous Mycobacterium