title: Clinical profile of dengue among children according to revised WHO classification: analysis of a 2012 outbreak from Southern India.
abstract: OBJECTIVE
  To study the clinical profile of dengue fever and its outcome in children with application of revised WHO classification and to identify risk factors for severe dengue.
  
  
  METHODS
  This study was a prospective observational study of children diagnosed with dengue from July 2012 through February 2013 at a tertiary care hospital in Bangalore, Karnataka (South India).
  
  
  RESULTS
  Eighty one children including 55(67.9 %) boys and 26(32.1 %) girls were diagnosed with dengue. Mean age of presentation was 8 y. Vomiting (60.5 %), pain abdomen (32 %), headache (30.9 %), myalgia (23.5 %) and bleeding manifestations (16 %) were the common presenting complaints. Facial puffiness (63 %), hepatomegaly (51.9 %), ascites (48.1 %), pleural effusion (39.5 %) and petechiae (14.8 %) were noted during examination. Dengue NS1 antigen, IgM, IgG were positive in 66.7 %, 29.6 % and 18.5 % of cases respectively. Investigations showed hemoconcentration in 72.8 %, leucopenia (34.5 %), thrombocytopenia (82.7 %), abnormal liver function test (LFT) (33.3 %). USG abdomen was suggestive of dengue in 66.7 % and gall bladder edema was noted in 53.1 %. Two patients died out of the total 81 patients with mortality rate of 2.5 %. Number of cases classified as Dengue without warning signs (D), Dengue with warning signs (DW) and Severe Dengue (SD) were 48.1 %, 27.2 % and 24.7 % respectively.
  
  
  CONCLUSIONS
  Children between 5 and 15 y were most affected by dengue fever. Pain abdomen and vomiting were most common presenting symptoms. Ascites, plerural effusion, hepatomegaly, gall bladder wall thickening and abnormal LFT were found significantly high in severe dengue cases.
authors.affiliation: Department of Pediatrics, Sapthagiri Institute of Medical Sciences and Research Center, Bangalore, India, dr_sahana2003@yahoo.co.in.
authors.forename: K S
authors.initials: KS
authors.lastname: Sahana
authors.forename: R
authors.initials: R
authors.lastname: Sujatha
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003715:Dengue / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D003716:Dengue Virus / Q000276:immunology*; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D012307:Risk Factors; D019595:Severe Dengue / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D063189:Symptom Assessment / Q000379:methods / Q000706:statistics & numerical data; D014839:Vomiting / Q000209:etiology; D014944:World Health Organization