title: Qiguiyishen decoction reduced the accumulation of extracellular matrix in the kidneys of rats with adriamycin-induced nephropathy.
abstract: OBJECTIVE
  To investigate the effect of Qiguiyishen decoction (QGYS) on the severity of nephropathy.
  
  
  METHODS
  Twenty-four rats were randomly divided into four groups (I, II, III, IV) according to the random number table. Group I as control group did not establish nephropathy model. Groups II, III, and IV were intravenously administered Adriamycin (7.5 mg/kg) through the tail vein to establish nephropathy model. QGYS was prepared with the extracts of Huangqi (Radix Astragali Mongolici), Danggui (Radix Angelicae Sinensis), Niuxi (Radix Achyranthis Bidentatae), and Chuanxiong (Rhizoma Chuanxiong). Group IV was administered QGYS (2 mL x kg(-1) x d(-1)), group III was administered benazepril (10 mL x kg(-1) x d(-1)), and group I, II was administered water (2 mL x kg(-1) x d(-1)) once daily for eight weeks.
  
  
  RESULTS
  QGYS reduced the excretion of urinary protein and N-acetyl-beta-D-glucosaminidase and alleviated the accumulation of extracellular matrix (ECM) in renal tissue. Additionally, QGYS effectively regulated the levels of transforming growth factor, tissue inhibitor of matrix metalloproteinase, and matrix metalloproteinases in the kidney of the rats.
  
  
  CONCLUSIONS
  QGYS may reduce the accumulation of ECM in the kidneys of rats with Adriamycin-induced nephropathy.
authors.forename: Minggang
authors.initials: M
authors.lastname: Wei
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
authors.forename: Weiming
authors.initials: W
authors.lastname: He
authors.forename: Li
authors.initials: L
authors.lastname: Ni
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Cai
authors.forename: Zongqi
authors.initials: Z
authors.lastname: Cheng
authors.forename: Kun
authors.initials: K
authors.lastname: Gao
authors.forename: Fengling
authors.initials: F
authors.lastname: Li
authors.forename: Lin
authors.initials: L
authors.lastname: Chen
authors.forename: Xinping
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000818:Animals; D015536:Down-Regulation / Q000187:drug effects; D004317:Doxorubicin / Q000009:adverse effects*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005109:Extracellular Matrix / Q000201:enzymology / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D007674:Kidney Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D045726:Metalloproteases / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004365:Drugs, Chinese Herbal; D004317:Doxorubicin; D045726:Metalloproteases