title: Primary paraganglioma of the spine: A clinicopathological study of eight cases.
abstract: BACKGROUND
  Spinal paragangliomas are rare neuroendocrine tumors of the extra-adrenal paraganglionic system.
  
  
  OBJECTIVE
  This study describes the clinicopathological features of eight cases of spinal paraganglioma and highlights the significance of important morphological features and immunohistochemistry in the diagnosis of paraganglioma at this unusual site.
  
  
  METHODS
  All the cases of primary spinal paragangliomas diagnosed during the last six years (2008-2013) in the Department of Pathology at our hospital were reviewed.
  
  
  RESULTS
  There were six males and two females. The mean age at diagnosis was 50.4 years. All patients presented with low back pain. All tumors were located in the cauda equina or conus medullaris region. Magnetic Resonance Imaging and intraoperative appearance were that of a vascular, well-circumscribed intradural, extramedullary tumor suggestive of either schwannoma or ependymoma. All the patients underwent gross total resection of the tumor. Histopathology in five of the cases showed 'ependymoma-like histology' while only three cases had a predominant classic 'zellballen' pattern. Two cases had prominent 'gangliocytic differentiation'. In the five cases with 'ependymoma-like histology', the diagnosis was confirmed on Immunohistochemistry (IHC).
  
  
  CONCLUSIONS
  Even though relatively rare, paraganglioma should be considered in the differential diagnosis of spinal tumors and due to their clinical, radiological and histopathological similarity to schwannoma and ependymoma, the diagnosis should be based on close examination of the clinical, radiological and pathological findings.
authors.affiliation: Department of Pathology, King Edward Memorial Hospital, Seth Gordhandas Sunderdas Medical College, Parel, Mumbai, Maharashtra, India.
authors.forename: Toshi
authors.initials: T
authors.lastname: Mishra
authors.affiliation: Department of Pathology, King Edward Memorial Hospital, Seth Gordhandas Sunderdas Medical College, Parel, Mumbai, Maharashtra, India.
authors.forename: Naina A
authors.initials: NA
authors.lastname: Goel
authors.affiliation: Department of Neurosurgery, King Edward Memorial Hospital, Seth Gordhandas Sunderdas Medical College, Parel, Mumbai, Maharashtra, India.
authors.forename: Atul H
authors.initials: AH
authors.lastname: Goel
keywords: Cauda equina; ependymoma-like histology; paraganglioma; spinal