title: Bone regeneration by periosteal elevation using conventional orthodontic wire and uHA/PLLA mesh.
abstract: This study evaluated bone regeneration by periosteal elevation using conventional orthodontic wire and an unsintered hydroxyapatite (u-HA)/poly-L-lactic acid (PLLA) mesh in rabbit frontal bone. Thirty two rabbits (12-16 weeks: 2.5-3.0 kg) were used in this study. In the experimental group, 1 week after the mesh was inserted under the periosteal membrane, it was elevated by traction using the mesh connected with wire and two anchor screws. In the control group, the mesh was kept inserted under the periosteal membrane. Four animals were killed in each period in both groups, at 2, 3, 5 and 9 weeks postoperatively. Operated parts in the frontal bone were removed and prepared for radiological and histological assessment. The distance between the mesh and pristine bone (elevation length), the bone area and the expression of BMP-2 were evaluated. The value in the experimental group was significantly higher when compared to the control group (length P < 0.0001, bone area P < 0.0010, BMP-2 P = 0.0015). The BMP-2 labelling index after 3 weeks tended to be the largest in both groups. This study suggests that bone regeneration can be induced by periosteal elevation using a conventional orthodontic wire and an uHA/PLLA mesh.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Division of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato Chuo, Chuo-shi, Yamanashi 409-3898, Japan. Electronic address: msotobori@yamanashi.ac.jp.
authors.forename: Megumi
authors.initials: M
authors.lastname: Sotobori
authors.affiliation: Department of Oral and Maxillofacial Surgery, Division of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato Chuo, Chuo-shi, Yamanashi 409-3898, Japan.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Ueki
authors.affiliation: Department of Oral and Maxillofacial Surgery, Division of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato Chuo, Chuo-shi, Yamanashi 409-3898, Japan.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Ishihara
authors.affiliation: Department of Oral and Maxillofacial Surgery, Division of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato Chuo, Chuo-shi, Yamanashi 409-3898, Japan.
authors.forename: Akinori
authors.initials: A
authors.lastname: Moroi
authors.affiliation: Department of Oral and Maxillofacial Surgery, Division of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato Chuo, Chuo-shi, Yamanashi 409-3898, Japan.
authors.forename: Kohei
authors.initials: K
authors.lastname: Marukawa
authors.affiliation: Department of Oral and Maxillofacial Surgery, Division of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato Chuo, Chuo-shi, Yamanashi 409-3898, Japan.
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Nakazawa
authors.affiliation: Department of Oral and Maxillofacial Surgery, Division of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato Chuo, Chuo-shi, Yamanashi 409-3898, Japan.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Higuchi
authors.affiliation: Department of Oral and Maxillofacial Surgery, Division of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato Chuo, Chuo-shi, Yamanashi 409-3898, Japan.
authors.forename: Ran
authors.initials: R
authors.lastname: Iguchi
authors.affiliation: Department of Oral and Maxillofacial Surgery, Division of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato Chuo, Chuo-shi, Yamanashi 409-3898, Japan.
authors.forename: Hiroumi
authors.initials: H
authors.lastname: Ikawa
authors.affiliation: Department of Oral and Maxillofacial Surgery, Division of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato Chuo, Chuo-shi, Yamanashi 409-3898, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kosaka
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001696:Biomechanical Phenomena; D055396:Bone Morphogenetic Protein 2 / Q000032:analysis; D001861:Bone Regeneration / Q000502:physiology*; D001863:Bone Screws; D002508:Cephalometry / Q000379:methods; D003238:Connective Tissue / Q000473:pathology; D017886:Durapatite / Q000737:chemistry*; D005624:Frontal Bone / Q000473:pathology / Q000601:surgery*; D008297:Male; D009969:Orthodontic Wires; D010006:Osteoblasts / Q000473:pathology; D010012:Osteogenesis / Q000502:physiology; D010521:Periosteum / Q000473:pathology / Q000601:surgery*; D011091:Polyesters / Q000737:chemistry*; D011817:Rabbits; D013314:Stress, Mechanical; D013526:Surgical Mesh; D013997:Time Factors
chemical_list: D001672:Biocompatible Materials; D055396:Bone Morphogenetic Protein 2; D011091:Polyesters; C499699:hydroxyapatite-polylactide; D017886:Durapatite
keywords: Continuous force; Orthodontic wire; Periosteal elevation; uHA/PLLA mesh