title: Effects of urtica dioica extract on experimental acute pancreatitis model in rats.
abstract: Acute pancreatitis is the acute inflammation of pancreas and peripancreatic tissues, and distant organs are also affected. The aim of this study was to investigate the effect of Urtica dioica extract (UDE) treatment on cerulein induced acute pancreatitis in rats. Twenty-one Wistar Albino rats were divided into three groups: Control, Pancreatitis, and UDE treatment group. In the control group no procedures were performed. In the pancreatitis and treatment groups, pancreatitis was induced with intraperitoneal injection of cerulein, followed by intraperitoneal injection of 1 ml saline (pancreatitis group) and 1 ml 5.2% UDE (treatment group). Pancreatic tissues were examined histopathologically. Pro-inflammatory cytokines (tumor necrosis factor-α), amylase and markers of apoptosis (M30, M65) were also measured in blood samples. Immunohistochemical staining was performed with Caspase-3 antibody. Histopathological findings in the UDE treatment group were less severe than in the pancreatitis group (5.7 vs 11.7, p = 0.010). TNF-α levels were not statistically different between treated and control groups (63.3 vs. 57.2, p = 0.141). UDE treatment was associated with less apoptosis [determined by M30, caspase-3 index (%)], (1.769 vs. 0.288, p = 0.056; 3% vs. 2.2%, p = 0.224; respectively). UDE treatment of pancreatitis merits further study.
authors.affiliation: Department of Gastroenterology, Diskapi Yildirim Beyazit Education and Research Hospital Ankara, Turkey.
authors.forename: Baris
authors.initials: B
authors.lastname: Yilmaz
authors.affiliation: Department of Gastroenterology, Diskapi Yildirim Beyazit Education and Research Hospital Ankara, Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Basar
authors.affiliation: Department of Gastroenterology, Diskapi Yildirim Beyazit Education and Research Hospital Ankara, Turkey.
authors.forename: Bora
authors.initials: B
authors.lastname: Aktas
authors.affiliation: Department of Gastroenterology, Diskapi Yildirim Beyazit Education and Research Hospital Ankara, Turkey.
authors.forename: Akif
authors.initials: A
authors.lastname: Altinbas
authors.affiliation: Department of Gastroenterology, Diskapi Yildirim Beyazit Education and Research Hospital Ankara, Turkey.
authors.forename: Fuat
authors.initials: F
authors.lastname: Ekiz
authors.affiliation: Department of Emergency, Diskapi Yildirim Beyazit Education and Research Hospital Ankara, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Büyükcam
authors.affiliation: Department of Pathology, Diskapi Yildirim Beyazit Education and Research Hospital Ankara, Turkey.
authors.forename: Aynur
authors.initials: A
authors.lastname: Albayrak
authors.affiliation: Department of Biochemistry, Diskapi Yildirim Beyazit Education and Research Hospital Ankara, Turkey.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Ginis
authors.affiliation: Department of Biochemistry, Diskapi Yildirim Beyazit Education and Research Hospital Ankara, Turkey.
authors.forename: Gülfer
authors.initials: G
authors.lastname: Oztürk
authors.affiliation: Department of Gastroenterology, Diskapi Yildirim Beyazit Education and Research Hospital Ankara, Turkey.
authors.forename: Sahin
authors.initials: S
authors.lastname: Coban
authors.affiliation: Department of Gastroenterology, Diskapi Yildirim Beyazit Education and Research Hospital Ankara, Turkey.
authors.forename: Engin
authors.initials: E
authors.lastname: Ucar
authors.affiliation: Department of Surgery, Diskapi Yildirim Beyazit Education and Research Hospital Ankara, Turkey.
authors.forename: Oskay
authors.initials: O
authors.lastname: Kaya
authors.affiliation: Department of Gastroenterology, Diskapi Yildirim Beyazit Education and Research Hospital Ankara, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Yüksel
authors.affiliation: Department of Endocrinology, Diskapi Yildirim Beyazit Education and Research Hospital Ankara, Turkey.
authors.forename: Sedat
authors.initials: S
authors.lastname: Caner
authors.affiliation: Department of Endocrinology, Diskapi Yildirim Beyazit Education and Research Hospital Ankara, Turkey.
authors.forename: Tuncay
authors.initials: T
authors.lastname: Delibasi
keywords: Pancreatitis; urtica dioica