title: Roles of elevated intravitreal IL-1β and IL-10 levels in proliferative diabetic retinopathy.
abstract: OBJECTIVE
  To determine the roles of interleukin (IL)-1β and IL-10 in the vitreous of proliferative diabetic retinopathy (PDR).
  
  
  METHODS
  Vitreous samples were obtained from 26 eyes of 26 patients with PDR and from eight eyes of eight cases without PDR. The IL-1β and IL-10 concentration in the vitreous was measured by using an enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  Levels of IL-1β and IL-10 in vitreous were higher in PDR patients compared with control group. And there was significantly negative correlation between IL-1β and IL-10 in control group (r = -0.795; P = 0.032), whereas there was no significant correlation in PDR group (r = 0.176; P = 0.391).
  
  
  CONCLUSIONS
  Levels of IL-1β and IL-10 were upregulated in vitreous of PDR patients, and these two cytokines play roles in regulating the development and progression of PDR.
authors.forename: Chunjie
authors.initials: C
authors.lastname: Mao
authors.affiliation: Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Yan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003930:Diabetic Retinopathy / Q000150:complications / Q000378:metabolism* / Q000601:surgery; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016753:Interleukin-10 / Q000378:metabolism*; D053583:Interleukin-1beta / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D014821:Vitrectomy; D018630:Vitreoretinopathy, Proliferative / Q000209:etiology / Q000378:metabolism* / Q000601:surgery; D014822:Vitreous Body / Q000378:metabolism*; D055815:Young Adult
chemical_list: C508609:IL10 protein, human; D053583:Interleukin-1beta; D016753:Interleukin-10