title: Downregulation of angiogenesis factors, VEGF and PDGF, after rapid IgE desensitization and oral immunotherapy in children with food allergy.
abstract: BACKGROUND
  Angiogenesis has a key role in several conditions and is regulated by several factors such as the platelet-derived growth factor (PDGF) or the vascular endothelial growth factor (VEGF). The goal of this study was to investigate the possible role of PDGF and VEGF in a group of patients with severe food allergy.
  
  
  METHODS
  We design a prospective longitudinal study (n = 30) with patients with persistent cow's milk proteins (CMP) allergy. After achieving a CMP rush desensitization protocol, a clinical followup including SPT and blood samples to determine sIgE, protein levels, PDGF, and VEGF-A and a panel of the most representative Th1, Th2, Treg, and Th17 cytokines were also monitored.
  
  
  RESULTS
  Baseline levels of PDGF and VEGF in the CMP allergic patients (1170 pg/mL and 253 pg/mL) were different compared to those nonallergic CMP control subjects (501 pg/mL and 108 pg/mL). Both PDGF and VEGF were significantly downregulated (P < 0.05) 6 months after completion of the CMP desensitization process and remained significantly decreased 12 months later.
  
  
  CONCLUSIONS
  The present study shows a significant increase of PDGF and VEGF in anaphylaxis suffering children compared to a control group. Interestingly, both VEGF and PDGF were significantly downregulated after completing a full CMP rush IgE desensitization.
authors.affiliation: Consulta de Alergia Infantil, Unidad de Alergología-Norte, Hospital del Tórax/Ofra, CHUNSC, Ofra, Spain.
authors.forename: Paloma
authors.initials: P
authors.lastname: Poza-Guedes
authors.affiliation: Immunology, Hospital Universitario de Canarias, La Laguna, Spain.
authors.forename: Yvelise
authors.initials: Y
authors.lastname: Barrios
authors.affiliation: Consulta de Alergia Infantil, Hospital Infantil Gregorio Marañon, Madrid, Spain.
authors.forename: Victoria
authors.initials: V
authors.lastname: Fuentes
authors.affiliation: Immunology, Hospital Universitario de Canarias, La Laguna, Spain.
authors.forename: Andres
authors.initials: A
authors.lastname: Franco
authors.affiliation: Consulta de Alergia Infantil, Unidad de Alergología-Norte, Hospital del Tórax/Ofra, CHUNSC, Ofra, Spain.
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Sánchez-Machín
authors.affiliation: Consulta de Alergia Infantil, Hospital Infantil Gregorio Marañon, Madrid, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Alonso
authors.affiliation: Consulta de Alergia Infantil, Unidad de Alergología-Norte, Hospital del Tórax/Ofra, CHUNSC, Ofra, Spain.
authors.forename: Ruperto
authors.initials: R
authors.lastname: González Pérez
authors.affiliation: Consulta de Alergia Infantil, Hospital Infantil Gregorio Marañon, Madrid, Spain.
authors.forename: Sonsoles
authors.initials: S
authors.lastname: Infante
authors.affiliation: Consulta de Alergia Infantil, Hospital Infantil Gregorio Marañon, Madrid, Spain.
authors.forename: Lydia
authors.initials: L
authors.lastname: Zapatero
authors.affiliation: Consulta de Alergia Infantil, Unidad de Alergología-Norte, Hospital del Tórax/Ofra, CHUNSC, Ofra, Spain ; Department of Clinical Sciences-Division IV, Lund University, Sweden.
authors.forename: Víctor
authors.initials: V
authors.lastname: Matheu
mesh_terms: D000293:Adolescent; D000818:Animals; D002417:Cattle; D002648:Child; D002675:Child, Preschool; D003888:Desensitization, Immunologic; D005260:Female; D005512:Food Hypersensitivity / Q000235:genetics* / Q000473:pathology; D005786:Gene Expression Regulation / Q000187:drug effects / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood* / Q000276:immunology; D007167:Immunotherapy; D008137:Longitudinal Studies; D008297:Male; D008894:Milk Proteins / Q000009:adverse effects*; D010982:Platelet-Derived Growth Factor / Q000096:biosynthesis* / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology; D058504:Th17 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis* / Q000097:blood / Q000276:immunology
chemical_list: D008894:Milk Proteins; D010982:Platelet-Derived Growth Factor; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; C075278:platelet-derived growth factor A; D007073:Immunoglobulin E