title: Anti-Mullerian hormone may be a useful adjunct in the diagnosis of polycystic ovary syndrome in nonobese adolescents.
abstract: OBJECTIVE
  This study aimed to [1] confirm that nonobese adolescents with polycystic ovary syndrome (PCOS) have higher anti-Mullerian hormone (AMH) than controls; [2] examine the relationship of AMH with PCOS features and hormonal profile; and [3] approximate an AMH value that discriminates between adolescents with PCOS and controls.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  Subspecialty ambulatory clinic.
  
  
  METHODS
  Thirty-one nonobese adolescent girls (age 13-21 years), 15 with PCOS diagnosed using the National Institutes of Health (NIH) criteria and 16 healthy control subjects. Subjects and controls were comparable for body mass index z-score, age and ethnicity.
  
  
  METHODS
  AMH in PCOS subjects and control groups, correlation of AMH with hormonal parameters.
  
  
  RESULTS
  AMH was higher in PCOS subjects (4.4±3.4 ng/mL) than in controls (2.4±1.3 ng/mL), when adjusted for menstrual age. In the entire group (PCOS and controls), AMH correlated with androgens, ovarian size and the presence of polycystic ovary (PCO) appearance. There was no difference in average ovarian size between PCOS (7.1±2.6 cm³) and controls (6.7±1.8 cm³). PCOS subjects were 1.49 times more likely to have AMH >3.4 ng/mL (confidence interval 0.98-2.26 ng/mL).
  
  
  CONCLUSIONS
  Our data suggest that AMH may be a useful adjunct in the diagnosis of PCOS in adolescents.
authors.forename: Aviva B
authors.initials: AB
authors.lastname: Sopher
authors.forename: Galina
authors.initials: G
authors.lastname: Grigoriev
authors.forename: Diana
authors.initials: D
authors.lastname: Laura
authors.forename: Tamara
authors.initials: T
authors.lastname: Cameo
authors.forename: Jodi P
authors.initials: JP
authors.lastname: Lerner
authors.forename: R Jeffrey
authors.initials: RJ
authors.lastname: Chang
authors.forename: Donald J
authors.initials: DJ
authors.lastname: McMahon
authors.forename: Sharon E
authors.initials: SE
authors.lastname: Oberfield
mesh_terms: D000293:Adolescent; D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D015992:Body Mass Index; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000175:diagnosis*; D011379:Prognosis; D055815:Young Adult
chemical_list: D015415:Biomarkers; D054304:Anti-Mullerian Hormone