title: Huntington disease: can a zebrafish trail leave more than a ripple?
abstract: Over the past decade, zebrafish has proved to be very useful in modeling neurodegenerative conditions. It poses a number of advantages and has been accepted as one of the best models for elucidating pathophysiological mechanisms of neurodegenerative diseases, including Huntington disease (HD). HD is a debilitating neurodegenerative genetic disorder that affects a person's ability to think, talk, and move. The pathophysiology of HD is not completely understood, which prevents the development of effective therapeutic approaches. Using zebrafish as a model organism, scientific advancements can be made in understanding the HD pathology/mechanisms with the hope of developing potential therapies in the near future.
authors.affiliation: School of Biotechnology, National Institute of Technology Calicut, NITC Campus PO, Calicut 673601, Kerala, India.
authors.forename: Sambit
authors.initials: S
authors.lastname: Das
authors.affiliation: School of Biotechnology, National Institute of Technology Calicut, NITC Campus PO, Calicut 673601, Kerala, India. Electronic address: rajanikant@nitc.ac.in.
authors.forename: G K
authors.initials: GK
authors.lastname: Rajanikant
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D006816:Huntington Disease / Q000503:physiopathology*; D009043:Motor Activity / Q000502:physiology*; D015027:Zebrafish / Q000502:physiology*
keywords: Huntington's disease; Model organism; Movement disorder; Zebrafish