title: Gas exchange and pulmonary hypertension following acute pulmonary thromboembolism: has the emperor got some new clothes yet?
abstract: Patients present with a wide range of hypoxemia after acute pulmonary thromboembolism (APTE). Recent studies using fluorescent microspheres demonstrated that the scattering of regional blood flows after APTE, created by the embolic obstruction unique in each patient, significantly worsened regional ventilation/perfusion (V/Q) heterogeneity and explained the variability in gas exchange. Furthermore, earlier investigators suggested the roles of released vasoactive mediators in affecting pulmonary hypertension after APTE, but their quantification remained challenging. The latest study reported that mechanical obstruction by clots accounted for most of the increase in pulmonary vascular resistance, but that endothelin-mediated vasoconstriction also persisted at significant level during the early phase.
authors.affiliation: Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: John Y C
authors.initials: JY
authors.lastname: Tsang
authors.affiliation: Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: James C
authors.initials: JC
authors.lastname: Hogg
keywords: fluorescent microspheres; pulmonary vasoconstriction; regional blood flow; ventilation-perfusion mismatch