title: Construction of a versatile and functional nanoparticle platform derived from a helical diblock copolypeptide-based biomimetic polymer.
abstract: Sequential polymerization ofN-carboxyanhydrides accelerated by nitrogen flow is utilized to generate a novel well-defined diblock copolypeptide (PDI = 1.08), with incorporation of alkyne-functionalized side-chain groups allowing for rapid and efficient thiol-yne click-type modifications, followed by self-assembly into nanopure water to construct a helical polypeptide-based versatile and functional nanoparticle platform.
authors.affiliation: Departments of Chemistry, Chemical Engineering, and Materials Science and Engineering, Laboratory for Synthetic-Biologic Interactions, Texas A&M University, P.O. BOX 30012, 3255 TAMU, College Station, TX, 77842 (USA).
authors.forename: Jingwei
authors.initials: J
authors.lastname: Fan
authors.affiliation: Departments of Chemistry, Chemical Engineering, and Materials Science and Engineering, Laboratory for Synthetic-Biologic Interactions, Texas A&M University, P.O. BOX 30012, 3255 TAMU, College Station, TX, 77842 (USA).
authors.forename: Richen
authors.initials: R
authors.lastname: Li
authors.affiliation: Departments of Chemistry, Chemical Engineering, and Materials Science and Engineering, Laboratory for Synthetic-Biologic Interactions, Texas A&M University, P.O. BOX 30012, 3255 TAMU, College Station, TX, 77842 (USA).
authors.forename: Xun
authors.initials: X
authors.lastname: He
authors.affiliation: Departments of Chemistry, Chemical Engineering, and Materials Science and Engineering, Laboratory for Synthetic-Biologic Interactions, Texas A&M University, P.O. BOX 30012, 3255 TAMU, College Station, TX, 77842 (USA).
authors.forename: Kellie
authors.initials: K
authors.lastname: Seetho
authors.affiliation: Departments of Chemistry, Chemical Engineering, and Materials Science and Engineering, Laboratory for Synthetic-Biologic Interactions, Texas A&M University, P.O. BOX 30012, 3255 TAMU, College Station, TX, 77842 (USA).
authors.forename: Fuwu
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Departments of Chemistry, Chemical Engineering, and Materials Science and Engineering, Laboratory for Synthetic-Biologic Interactions, Texas A&M University, P.O. BOX 30012, 3255 TAMU, College Station, TX, 77842 (USA).
authors.forename: Jiong
authors.initials: J
authors.lastname: Zou
authors.affiliation: Departments of Chemistry, Chemical Engineering, and Materials Science and Engineering, Laboratory for Synthetic-Biologic Interactions, Texas A&M University, P.O. BOX 30012, 3255 TAMU, College Station, TX, 77842 (USA).
authors.forename: Karen L
authors.initials: KL
authors.lastname: Wooley