title: Trichocladinols I-K, oxatricyclic and oxabicyclic polyketides from Trichocladium opacum.
abstract: Three new polyketides, trichocladinols I-K (1-3) with oxabicyclic (1 and 3) and oxatricyclic (2) skeletons, together with three knovwnl metabolites, massarilactone G (4), massarigenin D (5), and rosigenin (6), were isolated from the solid-substrate fermentation cultures of the ascomycete fungus Trichocladium opacum. The structures of the new compounds were elucidated primarily by analysis of NMR data. The absolute configurations of 1-3 were deduced from circular dichroism (CD) data. Compounds 1-3 were tested for cytotoxicity against five human carcinoma cell lines, HeLa, A549, MCF-7, HCT116, and T24. Compound I showed a weak cytotoxic effect against HeLa cells, but 2 and 3 were inactive.
authors.forename: Manyun
authors.initials: M
authors.lastname: Su
authors.forename: Shenxi
authors.initials: S
authors.lastname: Chen
authors.forename: Xingzhong
authors.initials: X
authors.lastname: Liu
authors.forename: Yuehu
authors.initials: Y
authors.lastname: Pei
mesh_terms: D001203:Ascomycota / Q000378:metabolism*; D045744:Cell Line, Tumor; D002942:Circular Dichroism; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D004224:Diterpenes; D007783:Lactones; D061065:Polyketides; C522457:massarilactone G