title: Genomic medicine and targeted therapy for solid tumors.
abstract: A marked paradigm shift in cancer therapy has occurred over the past 20 years. Systemic treatment has evolved from nonspecific cytotoxic chemotherapy to targeting cancer-associated pathways, profoundly changing treatment approaches in the metastatic and adjuvant settings. This review will highlight some of the major clinical advances in targeted cancer therapy in select epithelial malignancies made possible by the understanding of the molecular mechanisms driving tumor growth through genomic methods.
authors.affiliation: Seattle Cancer Care Alliance, University of Washington, Seattle, Washington; Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington.
authors.forename: Emily A
authors.initials: EA
authors.lastname: Stevens
authors.forename: Cristina P
authors.initials: CP
authors.lastname: Rodriguez
mesh_terms: D014408:Biomarkers, Tumor / Q000037:antagonists & inhibitors* / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D023281:Genomics; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000235:genetics* / Q000628:therapy*; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor
keywords: human genetics; individualized medicine; molecular targeted therapy; mutation; neoplasm