title: Meta-analysis of GSTM1 null genotype and lung cancer risk in Asians.
abstract: BACKGROUND
  Several molecular epidemiological studies have been conducted to examine the association between glutathione S-transferase M 1 (GSTM1) null genotype and lung cancer in Asians; however, the conclusions remained controversial. We therefore performed an extensive meta-analysis on 31 published case-control studies with a total of 5347 lung cancer cases and 6072 controls.
  
  
  METHODS
  PubMed and EMBASE were searched to identify case-control studies investigating the associations of GSTM1 null genotype with risk of lung cancer in Asians. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association between lung cancer risk and polymorphism of GSTM1.
  
  
  RESULTS
  GSTM1 null genotype was significantly associated with lung cancer risk (OR=1.43; 95% CI, 1.30-1.58). This result remained statistically significant when the adjusted ORs were combined (OR=1.38; 95% CI, 1.23-1.54). In the subgroup analysis by sex, there were significant associations in women and men. When stratifying for histology, this genotype showed increased adenocarcinoma risk and squamous cell carcinoma risk. In the subgroup analysis stratified by smoking status, lung cancer risk was increased in both smokers and non-smokers.
  
  
  CONCLUSIONS
  This study suggests that GSTM1 null genotype is a risk factor for lung cancer in Asians.
authors.affiliation: Department of Oncology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China (mainland).
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Oncology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China (mainland).
authors.forename: Zhijuan
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Oncology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China (mainland).
authors.forename: Zhiye
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Oncology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China (mainland).
authors.forename: Weimin
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Oncology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China (mainland).
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Oncology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China (mainland).
authors.forename: Zhongyue
authors.initials: Z
authors.lastname: Xiao
authors.affiliation: Department of Oncology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China (mainland).
authors.forename: Huazhuan
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Oncology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China (mainland).
authors.forename: Hongduo
authors.initials: H
authors.lastname: Jiao
authors.affiliation: Department of Oncology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China (mainland).
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Oncology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China (mainland).
authors.forename: Guoguo
authors.initials: G
authors.lastname: Li
mesh_terms: D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D008297:Male; D016017:Odds Ratio; D012307:Risk Factors
chemical_list: D005982:Glutathione Transferase