title: Metallothionein 3 expression in normal skin and malignant skin lesions.
abstract: Metallothionein-3 (MT-3) has been shown to be expressed in several malignancies and to have an impact on patients' survival in breast and urinary bladder cancer cases. However, its expression has not been determined in normal skin or in its malignant lesions. MT-3 expression was studied using immunohistochemistry in 17 cases of normal skin, 18 of actinic keratosis (AK), 39 of squamous cell carcinoma (SCC), and 23 of basal cell carcinoma (BCC). Low MT-3 expression was observed in normal skin epidermis with faint or no expression in the epidermis basal layer. Significantly higher MT-3 expression was noted in AK (P=0.007) and SCC (P<0.0001), as compared with normal skin epidermis. BCC cases were characterized by the lowest MT-3 expression of all the examined groups, which was significantly lower in comparison to normal skin epidermis, AK, and SCC (P=0.009;P<0.0001 and P<0.0001, respectively). In conclusion, MT-3 may be involved in the development of SCC.
authors.forename: Bartosz
authors.initials: B
authors.lastname: Pula
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Tazbierski
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Zamirska
authors.forename: Bozena
authors.initials: B
authors.lastname: Werynska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Bieniek
authors.forename: Jacek
authors.initials: J
authors.lastname: Szepietowski
authors.forename: Janusz
authors.initials: J
authors.lastname: Rys
authors.forename: Piotr
authors.initials: P
authors.lastname: Dziegiel
authors.forename: Marzena
authors.initials: M
authors.lastname: Podhorska-Okolow
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000378:metabolism; D005260:Female; D006801:Humans; D055623:Keratosis, Actinic / Q000378:metabolism; D008297:Male; D000090023:Metallothionein 3; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D012867:Skin / Q000378:metabolism*; D012871:Skin Diseases / Q000378:metabolism*; D012878:Skin Neoplasms / Q000378:metabolism*
chemical_list: D000090023:Metallothionein 3; D009419:Nerve Tissue Proteins