title: Inhibition of cell proliferation, migration and invasion of B16-F10 melanoma cells by α-mangostin.
abstract: In this study, we have evaluated the potential antineoplastic effects of α-mangostin (α-M), the most representative xanthone in Garcinia mangostana pericarp, on melanoma cell lines. This xanthone markedly inhibits the proliferation of high-metastatic B16-F10 melanoma cells. Furthermore, by deeply analyzing which steps in the metastatic process are influenced by xanthone it was observed that α-M strongly interferes with homotypic aggregation, adhesion, plasticity and invasion ability of B16-F10 cells, probably by the observed reduction of metalloproteinase-9 activity. The antiproliferative and antimetastatic properties of α-M have been established in human SK-MEL-28 and A375 melanoma cells. In order to identify pathways potentially involved in the antineoplastic properties of α-M, a comparative mass spectrometry proteomic approach was employed. These findings may improve our understanding of the molecular mechanisms underlying the anti-cancer effects of α-M on melanoma.
authors.affiliation: Department of Biology, University "Tor Vergata", Rome, Italy. Electronic address: beninati@bio.uniroma2.it.
authors.forename: Simone
authors.initials: S
authors.lastname: Beninati
authors.affiliation: Department of Biology, University "Tor Vergata", Rome, Italy.
authors.forename: Serafina
authors.initials: S
authors.lastname: Oliverio
authors.affiliation: Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: Martina
authors.initials: M
authors.lastname: Cordella
authors.affiliation: Regina Elena National Cancer Institute, Rome, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Rossi
authors.affiliation: Regina Elena National Cancer Institute, Rome, Italy.
authors.forename: Cinzia
authors.initials: C
authors.lastname: Senatore
authors.affiliation: Department of Biology, University "Tor Vergata", Rome, Italy.
authors.forename: Immacolata
authors.initials: I
authors.lastname: Liguori
authors.affiliation: Department of Biology, University "Tor Vergata", Rome, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Lentini
authors.affiliation: Department of Biology, University "Tor Vergata", Rome, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Piredda
authors.affiliation: Department of Biology, University "Tor Vergata", Rome, Italy; Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Tabolacci
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D008546:Melanoma, Experimental / Q000473:pathology*; D051379:Mice; D009361:Neoplasm Invasiveness / Q000517:prevention & control*; D009362:Neoplasm Metastasis / Q000517:prevention & control*; D044004:Xanthones / Q000494:pharmacology*
chemical_list: D044004:Xanthones; C021053:mangostin
keywords: Antimetastatic effects; Melanoma; Natural drugs; α-Mangostin