title: [Liver stiffness in animals with glutamate-induced obesity (according to shear wave ultrasound elastography)].
abstract: We studied changes of liver stiffness measured by SWE in animals with glutamate-induced obesity (GIO). We noted significant increase of LS on 63.6% compared to intact rats (P < 0.001). Histologically confirmed non-alcoholic steatosis diagnosed in 93.3% of animals with obesity. The AUROC of SWE for in animals with GIO was 0.983 (95% CI 0.955-0.999; P < 0.001). The optimal LS cutoff point for the prediction of steatosis were > 6.25 kPa, with sensitivity, specificity, PPV and NPV 86.6; 100; 100 and 93.7% respectively.
authors.forename: N M
authors.initials: NM
authors.lastname: Kobyliak
authors.forename: O B
authors.initials: OB
authors.lastname: Dynnyk
authors.forename: H P
authors.initials: HP
authors.lastname: Mykhal'chyshyn
authors.forename: P M
authors.initials: PM
authors.lastname: Bodnar
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005234:Fatty Liver / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology*; D008099:Liver / Q000000981:diagnostic imaging*; D009765:Obesity / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D012372:ROC Curve; D051381:Rats; D012680:Sensitivity and Specificity