title: Hypersensitivity to contrast media and dyes.
abstract: This article updates current knowledge on hypersensitivity reactions to diagnostic contrast media and dyes. After application of a single iodinated radiocontrast medium (RCM), gadolinium-based contrast medium, fluorescein, or a blue dye, a hypersensitivity reaction is not a common finding; however, because of the high and still increasing frequency of those procedures, patients who have experienced severe reactions are nevertheless frequently encountered in allergy departments. Evidence on allergologic testing and management is best for iodinated RCM, limited for blue dyes, and insufficient for fluorescein. Skin tests can be helpful in the diagnosis of patients with hypersensitivity reactions to these compounds.
authors.affiliation: Department of Dermatology and Allergy Biederstein, Technische Universität München, Biedersteiner Strasse 29, Munich 80802, Germany. Electronic address: knut.brockow@lrz.tum.de.
authors.forename: Knut
authors.initials: K
authors.lastname: Brockow
authors.affiliation: Allergy and Clinical Immunology Department, Centro Médico Docente La Trinidad, Clínica El Avila, 6a transversal de Altamira, piso 8, consultorio 803, Caracas 1060, Venezuela.
authors.forename: Mario
authors.initials: M
authors.lastname: Sánchez-Borges
mesh_terms: D004396:Coloring Agents / Q000009:adverse effects* / Q000145:classification; D003287:Contrast Media / Q000009:adverse effects* / Q000145:classification; D019468:Disease Management; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology / Q000628:therapy*; D006801:Humans; D015994:Incidence; D012307:Risk Factors
chemical_list: D004396:Coloring Agents; D003287:Contrast Media
keywords: Blue dyes; Diagnostic procedure; Dyes; Fluorescein; Gadolinium-based contrast media; Hypersensitivity; Management; Radiocontrast media