title: Autologus bone marrow stem cells in atrophic acne scars: A pilot study.
abstract: BACKGROUND
  Acne scar is a very distressing and difficult problem for physicians and patients. Management of cutaneous scarring from acne can be challenging and confusing. The available modalities may be effective, having considerable morbidity and long downtime. Besides, they may not have the same efficacy in different skin types or acne scar types.
  
  
  OBJECTIVE
  To evaluate the short-term safety and efficacy of autologous bone marrow (BM) stem cells (SCs) in treating atrophic acne scars.
  
  
  METHODS
  Fourteen patients with moderate to severe atrophic acne scars were included. All patients were subjected to single session of autologous BMSCs therapy. Each patient received 5 μg/kg/day granulocyte colony-stimulating factor (G-CSF) as a single subcutaneous dose for 2 successive days before BM aspiration. The SC-containing solution was injected under each scar intradermally. The scars of the patients were clinically assessed both qualitatively and quantitatively before and after 6 months. The patients were given a preformed questionnaire Cardiff acne disability index (CADI) before and after treatment.
  
  
  RESULTS
  After 6 months of the injection, there was significant improvement in the qualitative grading, quantitative grading and CADI scores. All types of scars showed significant improvement. No significant adverse effects were reported in any patient.
  
  
  CONCLUSIONS
  Autologous BMSCs seem to be a safe and effective treatment option for the management of all types of atrophic facial acne scars.
authors.affiliation: Department of Dermatology and Venereology, Tanta University Hospitals , Tanta , Egypt.
authors.forename: Zeinab A
authors.initials: ZA
authors.lastname: Ibrahim
authors.forename: Rania A
authors.initials: RA
authors.lastname: Eltatawy
authors.forename: Nahla R
authors.initials: NR
authors.lastname: Ghaly
authors.forename: Naeim M
authors.initials: NM
authors.lastname: Abd El-Naby
authors.forename: Heba M
authors.initials: HM
authors.lastname: Abou El Fetouh
authors.forename: Amal E
authors.initials: AE
authors.lastname: Abd Elateef
authors.forename: Said
authors.initials: S
authors.lastname: Abdou
authors.forename: Ateef
authors.initials: A
authors.lastname: Tahaa
authors.forename: Mohamed
authors.initials: M
authors.lastname: El Afandy
mesh_terms: D000152:Acne Vulgaris / Q000150:complications*; D000328:Adult; D016026:Bone Marrow Transplantation / Q000379:methods*; D002921:Cicatrix / Q000209:etiology / Q000628:therapy*; D005145:Face; D005260:Female; D006801:Humans; D007267:Injections; D008297:Male; D010865:Pilot Projects; D016896:Treatment Outcome
keywords: Acne; atropic scars; injection; stem cell