title: Cross talk between the metabolic and immune systems.
abstract: Understanding the interplay between metabolic and cellular signaling systems has emerged as a focus in the study of metabolic disorders, cancer, and immune responses. Immune system is active in the regulation of metabolism. Lymphocyte activation initiates a program of cell growth, proliferation, and differentiation that increase metabolic demand. Activated lymphocytes must alter their metabolism to support these increased synthetic activities. In this chapter, we describe how signaling via the immune system integrates with metabolic functions to control immune response and vice versa. It has been explained mainly in the context of T lymphocyte activation and, to a lesser detail, in other immune cell types.
authors.affiliation: Machine Intelligence Unit, Indian Statistical Institute, 203 Barrackpore Trunk Road, Kolkata, 700108, India, namrata_t@isical.ac.in.
authors.forename: Namrata
authors.initials: N
authors.lastname: Tomar
authors.forename: Rajat K
authors.initials: RK
authors.lastname: De
mesh_terms: D000273:Adipose Tissue / Q000276:immunology / Q000378:metabolism; D000818:Animals; D005947:Glucose / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007107:Immune System / Q000276:immunology* / Q000378:metabolism; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism; D053858:Metabolic Networks and Pathways; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000276:immunology / Q000378:metabolism
chemical_list: D051193:Toll-Like Receptors; D005947:Glucose