title: Suppression and enhancement of transcriptional noise by DNA looping.
abstract: DNA looping has been observed to enhance and suppress transcriptional noise but it is uncertain which of these two opposite effects is to be expected for given conditions. Here, we derive analytical expressions for the main quantifiers of transcriptional noise in terms of the molecular parameters and elucidate the role of DNA looping. Our results rationalize paradoxical experimental observations and provide the first quantitative explanation of landmark individual-cell measurements at the single molecule level on the classical lac operon genetic system [Choi, L. Cai, K. Frieda, and X. S. Xie, Science 322, 442 (2008)].
authors.affiliation: Biophysics Unit (CSIC-UPV/EHU) and Department of Biochemistry and Molecular Biology, University of the Basque Country UPV/EHU, P.O. Box 644, 48080 Bilbao, Spain and IKERBASQUE, Basque Foundation for Science, 48011 Bilbao, Spain.
authors.forename: Jose M G
authors.initials: JM
authors.lastname: Vilar
authors.affiliation: Department of Biomedical Engineering, University of California, 451 East Health Sciences Drive, Davis, California 95616, USA.
authors.forename: Leonor
authors.initials: L
authors.lastname: Saiz
mesh_terms: D003198:Computer Simulation; D004269:DNA, Bacterial; D004926:Escherichia coli; D007763:Lac Operon; D008957:Models, Genetic; D009690:Nucleic Acid Conformation; D011336:Probability; D012333:RNA, Messenger; D013269:Stochastic Processes; D014158:Transcription, Genetic
chemical_list: D004269:DNA, Bacterial; D012333:RNA, Messenger