title: Inching toward cure of acute myeloid leukemia: a summary of the progress made in the last 50 years.
abstract: Despite some claims to the contrary, I believe substantial progress has been made in the last half century toward cure of acute myeloid leukemia in children and adults. The tried and true mechanism for this progress has been clinical trial and error. This method has been supplemented with an ever-increasing amount of work at the clinical laboratory interface that is beginning to allow us to develop specific therapy for afflicted individuals. This review details where we stand today and how we got here.
authors.affiliation: Cancer Research Foundation of New York, New York, NY, USA, pwiernik@aol.com.
authors.forename: Peter H
authors.initials: PH
authors.lastname: Wiernik
mesh_terms: D000617:Aminoglycosides / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001374:Azacitidine / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D000079982:Gemtuzumab; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000235:genetics / Q000601:surgery; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy; D058990:Molecular Targeted Therapy; D011379:Prognosis; D012074:Remission Induction / Q000379:methods; D016896:Treatment Outcome
chemical_list: D000617:Aminoglycosides; D061067:Antibodies, Monoclonal, Humanized; D000079982:Gemtuzumab; D001374:Azacitidine