title: Cutaneous reactions to chemotherapeutic drugs and targeted therapy for cancer: Part II. Targeted therapy.
abstract: Targeted drugs are increasingly being used for cancer management. They are designed to block specific cancer cell processes, and are often better tolerated than conventional chemotherapeutic drugs. Cutaneous reactions, however, are not uncommon, because some target molecules are also present in the skin. Tyrosine kinase inhibitors can cause edema and macular rash, whereas papulopustular rash, paronychia, regulatory changes in hair, itching, and dryness caused by epidermal growth factor receptor inhibitors (PRIDE) syndrome can be seen in patients treated with these drugs. Vismodegib may result in muscle spasms and alopecia. Multiple rashes can be seen with bortezomib, while sunitinib and sorafenib cause hand-foot skin reactions. New melanoma therapies, such as ipilimumab, cause immune-related adverse events of dermatitis and pruritus, while BRAF inhibitors can produce exanthematous rash and lead to an increased risk of squamous cell carcinoma. Dermatologists should be aware of these new therapies and their cutaneous reactions to be able to provide appropriate care and management for cancer patients.
authors.affiliation: Los Banos Doctors Hospital and Medical Center, Los Banos, Laguna, Philippines.
authors.forename: Claire Marie
authors.initials: CM
authors.lastname: Reyes-Habito
authors.affiliation: Harvard Medical School and Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts. Electronic address: ekroh@partners.org.
authors.forename: Ellen K
authors.initials: EK
authors.lastname: Roh
mesh_terms: D020533:Angiogenesis Inhibitors / Q000009:adverse effects; D061067:Antibodies, Monoclonal, Humanized / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000009:adverse effects; D016503:Drug Delivery Systems / Q000379:methods; D003875:Drug Eruptions / Q000209:etiology* / Q000628:therapy*; D004502:Education, Medical, Continuing; D015316:Genetic Therapy / Q000009:adverse effects; D053823:Hedgehog Proteins / Q000037:antagonists & inhibitors; D006801:Humans; D058990:Molecular Targeted Therapy / Q000009:adverse effects*
chemical_list: D020533:Angiogenesis Inhibitors; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D053823:Hedgehog Proteins
keywords: cancer therapy; chemotherapy; cutaneous reactions; drug hypersensitivity; rash; target drugs