title: MKK6 is upregulated in human esophageal, stomach, and colon cancers.
abstract: Expression analysis of MKK6 protein in solid tumors has never been investigated. Here, we report systematic analysis of MKK6 protein in different types of human tumor samples using western blotting and immunofluorescence techniques. We observed significant increase in the expression of MKK6 in Esophageal, Stomach, and Colon cancers as compared to controls. Results were alternately confirmed by Immunofluorescence studies. Upregulation of MKK6 protein is indicative of its role in human cancers and could possibly be used as a novel diagnostic or prognostic marker in these cancers.
authors.affiliation: Department of Biotechnology, University of Kashmir , Srinagar, Jammu and Kashmir , India , 1.
authors.forename: Arif Ali
authors.initials: AA
authors.lastname: Parray
authors.forename: Rafia Anjum
authors.initials: RA
authors.lastname: Baba
authors.forename: Hina Fayaz
authors.initials: HF
authors.lastname: Bhat
authors.forename: Lateef
authors.initials: L
authors.lastname: Wani
authors.forename: Taseem Ahmad
authors.initials: TA
authors.lastname: Mokhdomi
authors.forename: Umar
authors.initials: U
authors.lastname: Mushtaq
authors.forename: Sehar Saleem
authors.initials: SS
authors.lastname: Bhat
authors.forename: Deeba
authors.initials: D
authors.lastname: Kirmani
authors.forename: Sanaullah
authors.initials: S
authors.lastname: Kuchay
authors.forename: Mudassir Maqbool
authors.initials: MM
authors.lastname: Wani
authors.forename: Firdous Ahmad
authors.initials: FA
authors.lastname: Khanday
mesh_terms: D003110:Colonic Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D004938:Esophageal Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D006801:Humans; D048669:MAP Kinase Kinase 6 / Q000096:biosynthesis* / Q000235:genetics; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D015854:Up-Regulation
chemical_list: D048669:MAP Kinase Kinase 6; C482566:MAP2K6 protein, human
keywords: Cancers; MKK6; Protein expression