title: Multiorgan transplantation from a deceased donor with intravascular diffuse large B-cell lymphoma: transmission of the disease and results of treatment.
abstract: This report presents the transplantation of two kidneys and the liver from a deceased donor with suspected autoimmune encephalomeningitis (ADEM). Due to an atypical post-transplantation clinical course, the transplanted kidneys were biopsied and this disclosed diffuse large B-cell (DLBC) lymphoma of the intravascular type in each kidney. The same malignancy was found in the postmortem donor brain examination. The renal allografts from the two recipients were removed: despite every effort, one patient died, while chemotherapy was successful in the second. No malignancy was observed in the liver transplant recipient, who received prophylactic chemotherapy. These cases highlight the occasional failure of organ donor disease screening and the consequent unforeseen complications.
authors.affiliation: Nephrology-Transplant Center, Department of the Regional Public Hospital in Szczecin, Szczecin, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Dziewanowski
authors.forename: Radosław
authors.initials: R
authors.lastname: Drozd
authors.forename: Miłosz
authors.initials: M
authors.lastname: Parczewski
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Klinke
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D002102:Cadaver; D005260:Female; D006085:Graft Survival; D006801:Humans; D007674:Kidney Diseases / Q000601:surgery; D016030:Kidney Transplantation / Q000009:adverse effects*; D008107:Liver Diseases / Q000601:surgery; D016031:Liver Transplantation / Q000009:adverse effects*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D008875:Middle Aged; D011183:Postoperative Complications; D011379:Prognosis; D012307:Risk Factors; D014019:Tissue Donors; D014184:Transplantation, Homologous
chemical_list: D000970:Antineoplastic Agents
keywords: diffuse large B-cell lymphoma; kidney transplantation; liver transplantation; transplant complications