title: Drug allergy diagnosis.
abstract: Poorly documented and often self-reported drug hypersensitivity (DH) is a frequent problem in daily clinical practice and has a considerable impact on prescription choices. Little is known about the natural history of true DH. The suspicion of DH starts on clinical grounds. When assessing a patient with a presumed DH reaction in the symptomatic phase, it is mandatory to look for severity signs and, after doing so, to update the risk/benefit balance of exploring the suspected drug(s) on a case-by-case basis. With the help of allergy tests and a careful approach, a firm diagnosis is often possible.
authors.affiliation: Allergy Unit, Respiratoty and Addictology Department, Hôpital Arnaud de Villeneuve, 371, Avenue du Doyen Gaston Giraud, University Hospital of Montpellier Cedex 5, Montpellier 34295, France.
authors.forename: Anca M
authors.initials: AM
authors.lastname: Chiriac
authors.affiliation: Allergy Unit, Respiratoty and Addictology Department, Hôpital Arnaud de Villeneuve, 371, Avenue du Doyen Gaston Giraud, University Hospital of Montpellier Cedex 5, Montpellier 34295, France; Sorbonne Universités, UPMC Paris 06, UMR-S 1136, IPLESP, Equipe EPAR, Paris 75013, France. Electronic address: pascal.demoly@inserm.fr.
authors.forename: Pascal
authors.initials: P
authors.lastname: Demoly
mesh_terms: D015897:Comorbidity; D003888:Desensitization, Immunologic; D019468:Disease Management; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D006801:Humans; D060735:Pharmacovigilance; D012307:Risk Factors; D012720:Severity of Illness Index; D012882:Skin Tests
keywords: Drug allergy work-up; Drug hypersensitivity reaction; Imputability; Natural history; Severity signs