title: Clock genes in hypertension: novel insights from rodent models.
abstract: The circadian clock plays an integral role in the regulation of physiological processes, including the regulation of blood pressure. However, deregulation of the clock can lead to pathophysiological states including hypertension. Recent work has implicated the circadian clock genes in the regulation of processes in the heart, kidney, vasculature, and the metabolic organs, which are all critical in the regulation of the blood pressure. The goal of this review is to provide an introduction and general overview into the role of circadian clock genes in the regulation of blood pressure with a focus on their deregulation in the etiology of hypertension. This review will focus on the core circadian clock genes CLOCK, BMAL1, Per, and Cry.
authors.affiliation: Departments of aMedicine bBiochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USA.
authors.forename: Jacob
authors.initials: J
authors.lastname: Richards
authors.forename: Alexander N
authors.initials: AN
authors.lastname: Diaz
authors.forename: Michelle L
authors.initials: ML
authors.lastname: Gumz
mesh_terms: D056930:ARNTL Transcription Factors / Q000235:genetics / Q000502:physiology; D000450:Aldosterone / Q000502:physiology; D000818:Animals; D001808:Blood Vessels / Q000503:physiopathology; D056926:CLOCK Proteins / Q000235:genetics / Q000502:physiology; D002940:Circadian Rhythm / Q000235:genetics / Q000502:physiology* / Q000528:radiation effects; D056931:Cryptochromes / Q000235:genetics / Q000502:physiology; D003920:Diabetes Mellitus / Q000235:genetics / Q000503:physiopathology; D003921:Diabetes Mellitus, Experimental / Q000235:genetics / Q000503:physiopathology; D025461:Feedback, Physiological; D005247:Feeding Behavior / Q000502:physiology; D020022:Genetic Predisposition to Disease; D006321:Heart / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000503:physiopathology; D007668:Kidney / Q000503:physiopathology; D008027:Light; D024821:Metabolic Syndrome / Q000235:genetics / Q000503:physiopathology; D051379:Mice; D018345:Mice, Knockout; D023421:Models, Animal; D008954:Models, Biological; D009318:Natriuresis / Q000502:physiology; D056950:Period Circadian Proteins / Q000235:genetics / Q000502:physiology; D012377:Rodentia / Q000235:genetics / Q000502:physiology*; D012982:Sodium, Dietary / Q000493:pharmacokinetics / Q000633:toxicity
chemical_list: D056930:ARNTL Transcription Factors; D056931:Cryptochromes; D056950:Period Circadian Proteins; D012982:Sodium, Dietary; D000450:Aldosterone; D056926:CLOCK Proteins