title: Optimization of MR imaging for pretreatment evaluation of patients with endometrial and cervical cancer.
abstract: Endometrial and cervical cancer are the most common gynecologic malignancies in the world. Accurate staging of cervical and endometrial cancer is essential to determine the correct treatment approach. The current International Federation of Gynecology and Obstetrics (FIGO) staging system does not include modern imaging modalities. However, magnetic resonance (MR) imaging has proved to be the most accurate noninvasive modality for staging endometrial and cervical carcinomas and often helps with risk stratification and making treatment decisions. Multiparametric MR imaging is increasingly being used to evaluate the female pelvis, an approach that combines anatomic T2-weighted imaging with functional imaging (ie, dynamic contrast material-enhanced and diffusion-weighted imaging). MR imaging helps guide treatment decisions by depicting the depth of myometrial invasion and cervical stromal involvement in patients with endometrial cancer and tumor size and parametrial invasion in those with cervical cancer. However, its accuracy for local staging depends on technique and image quality, namely thin-section high-resolution multiplanar T2-weighted imaging with simple modifications, such as double oblique T2-weighting supplemented by diffusion weighting and contrast enhancement.
authors.affiliation: From the Departments of Diagnostic Radiology (G.M.R., H.K., H.C., R.D.E., P.B., L.P.M.), Radiation Oncology (A.H.K.), and Gynecologic Oncology and Reproductive Medicine (S.N.W.), University of Texas MD Anderson Cancer Center, 1400 Pressler St, Mail Unit 1473, Houston, TX 77030-4009.
authors.forename: Gaiane M
authors.initials: GM
authors.lastname: Rauch
authors.forename: Harmeet
authors.initials: H
authors.lastname: Kaur
authors.forename: Haesun
authors.initials: H
authors.lastname: Choi
authors.forename: Randy D
authors.initials: RD
authors.lastname: Ernst
authors.forename: Ann H
authors.initials: AH
authors.lastname: Klopp
authors.forename: Piyaporn
authors.initials: P
authors.lastname: Boonsirikamchai
authors.forename: Shannon N
authors.initials: SN
authors.lastname: Westin
authors.forename: Leonardo P
authors.initials: LP
authors.lastname: Marcal
mesh_terms: D016889:Endometrial Neoplasms / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000592:standards; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000628:therapy