title: Update on the management of neonatal sepsis in horses.
abstract: Despite advances in neonatal intensive care sepsis, severe sepsis and septic shock remain the biggest killers of neonatal foals. Management of this severe syndrome remains difficult, requiring intensive intervention. Key aspects of management include infection control, hemodynamic support, immunomodulatory interventions, and metabolic/endocrine support. Infection control largely consists of early antimicrobial therapy, plasma transfusions, and local therapy for the infected focus. In cases with severe sepsis or septic shock, hemodynamic support with fluids, vasoactive agents, and respiratory support insuring oxygen delivery to vital organs is important. Nutritional support is important, but close monitoring is needed to avoid hyperglycemia and hypoglycemia.
authors.affiliation: Graham French Neonatal Section, Connelly Intensive Care Unit, New Bolton Center, University of Pennsylvania, 382 West Street Road, Kennett Square, PA 19348, USA. Electronic address: jepalmer@vet.upenn.edu.
authors.forename: Jon
authors.initials: J
authors.lastname: Palmer
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D006734:Horse Diseases / Q000175:diagnosis* / Q000628:therapy*; D006736:Horses; D018805:Sepsis / Q000175:diagnosis / Q000628:therapy / Q000662:veterinary
keywords: Antimediator therapy; Antimicrobials; Corticosteroids; Fluid therapy; Glucose control; Septic shock; Severe sepsis; Vasoactive agents