title: [Change of auditory brainstem response in hearing deprivation rat model induced by bilateral cochlears ablation].
abstract: OBJECTIVE
  To observe the change of auditory brainstem response (ABR) in hearing deprivation rat model induced by bilateral cochlears ablation at different time points.
  
  
  METHODS
  Forty SD rats were randomly divided into four experiment groups including 2-week group, 4-week group, 6-week group, 8-week group and four control groups with 5 rats (n = 10) in each group. Then bilateral cochlears ablation was applied to experiment groups. The threshold value of ABR was measured at different time and latent period of each wave was compared.
  
  
  RESULTS
  The threshold of ABR in experiment group was elevated significantly. The latent period of each wave was pro longed significantly (P < 0.01). In experiment group, the threshold value of ABR in 2-week and 4-week group was significantly greater than that in 6-week group and 8-week group (P < 0.01).
  
  
  CONCLUSIONS
  Bilateral cochlears ablation surgery could elevate the threshold of ABR and latent period of each wave prolonged. The effect of hearing deprivation became apparent after surgery for 4 weeks.
authors.forename: Haixia
authors.initials: H
authors.lastname: Han
authors.forename: Ou
authors.initials: O
authors.lastname: Xu
authors.forename: Heyin
authors.initials: H
authors.lastname: Huang
authors.forename: Yuxing
authors.initials: Y
authors.lastname: Wang
authors.forename: Hong
authors.initials: H
authors.lastname: Lu
mesh_terms: D000818:Animals; D001309:Auditory Threshold; D003051:Cochlea / Q000503:physiopathology* / Q000601:surgery; D004195:Disease Models, Animal; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D034381:Hearing Loss; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley