title: Synthesis of some metallophthalocyanines with dimethyl 5-(phenoxy)-isophthalate substituents and evaluation of their antioxidant-antibacterial activities.
abstract: The synthesis, characterization, spectral, antioxidant and antibacterial properties of dimethyl 5-(phenoxy)-isophthalate substituted Zinc, Cobalt, Copper, and Nickel phthalocyanines are reported. The novel compounds have been characterized by using electronic absorption, nuclear magnetic resonance spectroscopy, infrared, elemental analysis and mass spectrometry. The antioxidant and antibacterial activities of newly synthesized phthalocyanines and its starting material are tested. The DPPH free radical scavenging ability of phthalocyanine Co(II) and Zn(II) complexes on DPPH are 44.8% and 40.1% at 100 mg/L concentration, respectively. The phthalocyanine Co(II) and Cu(II) complexes show very strong ferrous ion chelating activity of 91.2% and 89.3% at concentration of 100 mg/L, respectively. Compound 3 displays strong reducing power like α-tocopherol. Antibacterial activities of phthalocyanine Co(II) and Amikacin (30 μg/disk) against Micrococcus luteus (ATCC 9341) are 16 mm in diameter.
authors.affiliation: Department of Chemistry, Faculty of Science, Yüzüncü Yıl University, 65080 Van, Turkey. Electronic address: salihagirtas@hotmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Salih Ağırtaş
authors.affiliation: Department of Chemistry, Faculty of Science, Yüzüncü Yıl University, 65080 Van, Turkey.
authors.forename: Ceyhun
authors.initials: C
authors.lastname: Karataş
authors.affiliation: Department of Biology, Faculty of Arts and Science, Siirt University, 56100 Siirt, Turkey.
authors.forename: Sadin
authors.initials: S
authors.lastname: Özdemir
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000737:chemistry; D002614:Chelating Agents / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000494:pharmacology; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D054833:Isoindoles; D008670:Metals / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010084:Oxidation-Reduction / Q000187:drug effects; D010795:Phthalic Acids / Q000737:chemistry*; D010851:Picrates / Q000737:chemistry; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D002614:Chelating Agents; D016166:Free Radical Scavengers; D007211:Indoles; D054833:Isoindoles; D008670:Metals; D010795:Phthalic Acids; D010851:Picrates; C000598530:dimethyl 5-(phenoxy)-isophthalate; C059768:isophthalate; C004931:1,1-diphenyl-2-picrylhydrazyl; C013647:phthalocyanine
keywords: Antibacterial; Antioxidant; Characterization; Isophthalate; Phthalocyanine; Synthesis