title: Directing stem cell differentiation by changing the molecular mobility of supramolecular surfaces.
abstract: Polymer surfaces with a wide range of hydrated surface mobility are developed by a simple deposition method with supramolecular block copolymers. The morphologies of adhering stem cells are greatly dependent on the surface mobility of polymers, and this induces significant changes in the cytoskeletal signaling pathway to direct the downstream stem cell differentiation.
authors.affiliation: JST-CREST, Tokyo, 102-0076, Japan; Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda, Tokyo, 101-0062, Japan.
authors.forename: Ji-Hun
authors.initials: JH
authors.lastname: Seo
authors.forename: Sachiro
authors.initials: S
authors.lastname: Kakinoki
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Yamaoka
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Yui
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects / Q000235:genetics; D003505:Cyclodextrins / Q000737:chemistry / Q000494:pharmacology; D004548:Elasticity / Q000187:drug effects; D005786:Gene Expression Regulation / Q000187:drug effects; D008297:Male; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D018613:Microscopy, Confocal; D020442:Poloxamer / Q000737:chemistry / Q000494:pharmacology; D011108:Polymers / Q000494:pharmacology; D011916:Rats, Inbred F344; D043862:Rotaxanes / Q000737:chemistry / Q000494:pharmacology; D013499:Surface Properties; D014783:Viscosity / Q000187:drug effects
chemical_list: D003505:Cyclodextrins; D011108:Polymers; D043862:Rotaxanes; C475673:polyrotaxane; D020442:Poloxamer
keywords: PCR; QCM-D; mesenchymal stem cells; polyrotaxane; supramolecules