title: Association of heme oxygenase-1 gene rs2071746 polymorphism with vascular outcomes in patients with atherosclerotic stroke.
abstract: As an inducible isoform of heme oxygenase (HO), HO-1 was suggested to have an anti-oxidative stress, anti-inflammatory, anti-apoptotic and anti-proliferative effect. It was regarded as an important cytoprotective enzyme. We undertook this study to investigate whether HO-1 gene rs2071746 polymorphism was associated with clinical outcomes in atherosclerosis ischemic stroke patients. Between December 2009 and October 2012, consecutive atherosclerosis ischemic stroke patients were enrolled. The primary endpoint was the composite of vascular death, nonfatal ischemic stroke and myocardial infarct. A total of 961 patients were enrolled. After an average follow-up of 15.13 (SD=7.42) months, 89 patients (9.26%) had the primary endpoint. The cumulative incidence of the primary endpoint was significantly lower in A carriers (AT+AA) than TT genotype (7.9% vs. 12.2%, HR=0.648, 95% CI: 0.425-0.988, P=0.044). After adjustment for age, sex and other cardiovascular risk factors, we found that A carrier was an independent protective factor for atherosclerosis ischemic stroke (HR=0.646, 95% CI: 0.420-0.994, P=0.047). Age (HR=1.023, P=0.028) and low level of HDL (HR=1.772, P=0.012) were independent risk factors for the primary endpoint. In conclusion, HO-1 gene rs2071746 A allele carrier might be a protective factor for patients with atherosclerotic stroke.
authors.affiliation: Department of Neurology, Jinling Hospital, Southern Medical University, Nanjing 210002, China.
authors.forename: Liping
authors.initials: L
authors.lastname: Cao
authors.affiliation: Department of Neurology, Jinling Hospital, Southern Medical University, Nanjing 210002, China.
authors.forename: Zhizhong
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China.
authors.forename: Biyang
authors.initials: B
authors.lastname: Cai
authors.affiliation: Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Bai
authors.affiliation: Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China.
authors.forename: Yumeng
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Nanjing Jiangning Hospital, Nanjing 210002, China.
authors.forename: Wenshan
authors.initials: W
authors.lastname: Sun
authors.affiliation: Department of Neurology, Jinling Hospital, Southern Medical University, Nanjing 210002, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Xie
authors.affiliation: Department of Neurology, Jinling Hospital, Southern Medical University, Nanjing 210002, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Sun
authors.affiliation: Department of Neurology, Jinling Hospital, Southern Medical University, Nanjing 210002, China.
authors.forename: Qiankun
authors.initials: Q
authors.lastname: Cai
authors.affiliation: Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China.
authors.forename: Zhuangli
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Neurology, Jinling Hospital, Southern Medical University, Nanjing 210002, China.
authors.forename: Dezhi
authors.initials: D
authors.lastname: Liu
authors.affiliation: Department of Neurology, Jinling Hospital, Southern Medical University, Nanjing 210002, China.
authors.forename: Yunyun
authors.initials: Y
authors.lastname: Xiong
authors.affiliation: Department of Neurology, Jinling Hospital, Southern Medical University, Nanjing 210002, China.
authors.forename: Minmin
authors.initials: M
authors.lastname: Ma
authors.affiliation: Department of Neurology, Jinling Hospital, Southern Medical University, Nanjing 210002, China.
authors.forename: Xinfeng
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Neurology, Jinling Hospital, Southern Medical University, Nanjing 210002, China. Electronic address: gelinxu@gmail.com.
authors.forename: Gelin
authors.initials: G
authors.lastname: Xu
mesh_terms: D000368:Aged; D050197:Atherosclerosis / Q000150:complications*; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D051547:Heme Oxygenase-1 / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011110:Polymorphism, Genetic / Q000235:genetics*; D012189:Retrospective Studies; D012737:Sex Factors; D020521:Stroke / Q000209:etiology* / Q000235:genetics*
chemical_list: D051547:Heme Oxygenase-1
keywords: Atherosclerosis; Heme oxygenase-1 gene; Ischemic stroke; Single nucleotide polymorphism; Vascular outcome