title: [Association of 8-hydroxyguanine glycosidase OGG1 Ser326Cys polymorphism with male infertility].
abstract: OBJECTIVE
  To explore the association of 8-hydroxyguanine glycosidase OGG1 Ser326Cys polymorphism with semen quality and the risk of male infertility.
  
  
  METHODS
  This case-control study included 620 idiopathic infertile patients and 385 normal fertile controls. We determined their genotypes by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and analyzed their semen quality by computer-aided semen analysis (CASA).
  
  
  RESULTS
  The individuals with OGG1 326 Cys/Cys showed significantly lower sperm motility and concentration ([52.1 +/- 26.7]% and (3.75 +/- 0.91) x 10(6)/ml, ln transformed value) than the Ser/Ser carriers ([59.0 +/- 21.8] % and (4.12 +/- 0.88) x 10(6)/ml, ln transformed value) (P < 0.05). The risk of male infertility increased 69% in the OGG1 326Cys allele carriers as compared with the Ser carriers (OR = 1.69, 95% CI: 1.24 -2.31).
  
  
  CONCLUSIONS
  OGG1 326 Ser/Cys polymorphism might contribute to the risk of male infertility in the southern Chinese population.
authors.forename: Jian-Zhong
authors.initials: JZ
authors.lastname: Chen
authors.forename: Sheng-Min
authors.initials: SM
authors.lastname: Wu
authors.forename: Gui-Xiang
authors.initials: GX
authors.lastname: Ji
authors.forename: Ai-Hua
authors.initials: AH
authors.lastname: Gu
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D045647:DNA Glycosylases / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D055101:Semen Analysis; D055815:Young Adult
chemical_list: D045647:DNA Glycosylases; C479058:oxoguanine glycosylase 1, human