title: A simple assay for quality binders to cucurbiturils.
abstract: A new approach towards the rapid identification of quality binders to cucurbiturils--those that combine high affinity with high selectivity for a particular homologue--was developed. The assay exploits macrocycle-specific optical fingerprints (colorimetric or fluorimetric) of carefully selected indicators dyes. The screening of a guest library revealed known (e.g., adamantane derivatives) and new (e.g., terpenes) quality binders. The predictive power of the assay was underpinned by the modeling of the involved thermodynamic equilibria.
authors.affiliation: CIQSO - Center for Research in Sustainable Chemistry and Department of Chemical Engineering, Physical Chemistry, and Organic Chemistry, University of Huelva, Campus de El Carmen s/n, 21071 Huelva (Spain), Fax: (+34) 959 21 99 83.
authors.forename: Julián
authors.initials: J
authors.lastname: Vázquez
authors.forename: Patricia
authors.initials: P
authors.lastname: Remón
authors.forename: Roy N
authors.initials: RN
authors.lastname: Dsouza
authors.forename: Alexandra I
authors.initials: AI
authors.lastname: Lazar
authors.forename: Jesús F
authors.initials: JF
authors.lastname: Arteaga
authors.forename: Werner M
authors.initials: WM
authors.lastname: Nau
authors.forename: Uwe
authors.initials: U
authors.lastname: Pischel
keywords: cucurbiturils; fluorescence; host-guest systems; macrocycles; sensors