title: Anomia treatment platform as behavioral engine for use in research on physiological adjuvants to neurorehabilitation.
abstract: The purpose of this study was to create a "behavioral treatment engine" for future use in research on physiological adjuvants in aphasia rehabilitation. We chose the behavioral target anomia, which is a feature displayed by many persons who have aphasia. Further, we wished to saturate the treatment approach with many strategies and cues that have been empirically reported to have a positive influence on aphasia outcome, with the goal being to optimize the potential for positive response in most participants. A single-subject multiple baseline design with replication across eight participants was employed. Four men and four women, with an average age of 62 yr and an average of 63.13 mo poststroke onset, served as participants. Word-retrieval treatment was administered 3 d/wk, 1 h/d for a total of 20 treatment hours (6-7 wk). Positive acquisition effects were evident in all eight participants (d effect size [ES] = 5.40). Treatment effects were maintained 3 mo after treatment termination for five participants (d ES = 2.94). Within and across semantic category, generalization was minimal (d ES = 0.43 within and 1.09 across). This study demonstrates that this behavioral treatment engine provides a solid platform on which to base future studies whereby various treatment conditions are manipulated and pharmacologic support is added.
authors.affiliation: University of Washington, Speech and Hearing Sciences, 1417 42nd St NE, Seattle, WA 98105. dkendall@uw.edu.
authors.forename: Diane
authors.initials: D
authors.lastname: Kendall
authors.forename: Anastasia
authors.initials: A
authors.lastname: Raymer
authors.forename: Miranda
authors.initials: M
authors.lastname: Rose
authors.forename: JoEllen
authors.initials: J
authors.lastname: Gilbert
authors.forename: Leslie J
authors.initials: LJ
authors.lastname: Gonzalez Rothi
mesh_terms: D000368:Aged; D000849:Anomia / Q000209:etiology / Q000534:rehabilitation*; D001037:Aphasia / Q000209:etiology / Q000534:rehabilitation*; D035843:Biomedical Research; D015928:Cognitive Behavioral Therapy; D003463:Cues; D005260:Female; D006801:Humans; D007808:Language Therapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012660:Semantics; D020521:Stroke / Q000150:complications; D000071939:Stroke Rehabilitation
keywords: adjuvant; anomia; aphasia; behavioral treatment 
  engine; language; neurorehabilitation; pharmacology; rehabilitation; speech-language pathology; stroke