title: Acute myeloid leukemia with monosomal karyotype: morphologic, immunophenotypic, and molecular findings.
abstract: OBJECTIVE
  Acute myeloid leukemia (AML) with monosomal karyotype (MK) recently has been reported to be associated with worse outcome than the traditional complex karyotype.
  
  
  METHODS
  In this retrospective study of 111 patients with AML, we identified 14 patients with MK (13% of all patients with AML) using the definition proposed by Breems et al.
  
  
  RESULTS
  Five (36%) of these 14 patients had a loss of a single chromosome in the presence of other structural abnormalities, and nine (64%) had a loss of two or more autosomal chromosomes. Patients with AML-MK presented at an older age, with lower bone marrow blasts, and their blasts less frequently expressed CD34. Most patients with AML-MK had morphologic multilineage dysplasia and were predominantly subclassified as having AML with myelodysplasia-related changes (AML-MRC). Molecular analysis showed a significant absence of NPM1 and FLT3 in patients with AML-MK.
  
  
  CONCLUSIONS
  Outcome data showed that patients with AML-MK had significantly worse overall survival, disease-free survival, and complete response compared with the rest of the patients with AML as well as within the AML-MRC group.
authors.affiliation: From the Boston Children's Hospital, Boston, MA; Olga.Weinberg@childrens.harvard.edu.
authors.forename: Olga K
authors.initials: OK
authors.lastname: Weinberg
authors.affiliation: Stanford University Medical Center, Stanford, CA; and.
authors.forename: Robert S
authors.initials: RS
authors.lastname: Ohgami
authors.affiliation: Stanford University Medical Center, Stanford, CA; and.
authors.forename: Lisa
authors.initials: L
authors.lastname: Ma
authors.affiliation: Stanford University Medical Center, Stanford, CA; and.
authors.forename: Katie
authors.initials: K
authors.lastname: Seo
authors.affiliation: Stanford University Medical Center, Stanford, CA; and.
authors.forename: Li
authors.initials: L
authors.lastname: Ren
authors.affiliation: Stanford University Medical Center, Stanford, CA; and.
authors.forename: Jason R
authors.initials: JR
authors.lastname: Gotlib
authors.affiliation: Arizona Oncology, Scottsdale, AZ.
authors.forename: Mahesh
authors.initials: M
authors.lastname: Seetharam
authors.affiliation: Stanford University Medical Center, Stanford, CA; and.
authors.forename: Athena
authors.initials: A
authors.lastname: Cherry
authors.affiliation: Stanford University Medical Center, Stanford, CA; and.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Arber
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009006:Monosomy / Q000235:genetics*; D009190:Myelodysplastic Syndromes / Q000175:diagnosis / Q000235:genetics*; D000090243:Nucleophosmin; D012189:Retrospective Studies; D055815:Young Adult
keywords: Acute myeloid leukemia; Monosomal karyotype; Myelodysplasia