title: Morphology of susceptibility vessel sign predicts middle cerebral artery recanalization after intravenous thrombolysis.
abstract: OBJECTIVE
  We aimed to evaluate the predictive value of susceptibility vessel sign (SVS) burden and morphology in middle cerebral artery recanalization.
  
  
  METHODS
  We retrospectively examined clinical and imaging data from 72 consecutive patients with acute ischemic stroke with middle cerebral artery occlusion and examined the association of recanalization with SVS length and shape.
  
  
  RESULTS
  None of the patients with a middle cerebral artery SVS >20 mm in length achieved recanalization. For patients with a relatively short SVS (length <20 mm), irregular shape was a strong independent predictor for no recanalization (odds ratio, 6.891; 95% confidence interval, 1.441-32.950; P=0.016).
  
  
  CONCLUSIONS
  Irregular shape and long length (>20 mm) of SVS decrease the potential to recanalize the occluded middle cerebral artery with intravenous thrombolysis.
authors.affiliation: From the Department of Neurology, the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China (S.Y., H.H., X.Z., S.Z., M.L.); Department of Neurology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China (Z.S.); and University of California-Los Angeles Stroke Center (D.S.L.).
authors.forename: Shenqiang
authors.initials: S
authors.lastname: Yan
authors.affiliation: From the Department of Neurology, the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China (S.Y., H.H., X.Z., S.Z., M.L.); Department of Neurology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China (Z.S.); and University of California-Los Angeles Stroke Center (D.S.L.).
authors.forename: Haitao
authors.initials: H
authors.lastname: Hu
authors.affiliation: From the Department of Neurology, the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China (S.Y., H.H., X.Z., S.Z., M.L.); Department of Neurology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China (Z.S.); and University of California-Los Angeles Stroke Center (D.S.L.).
authors.forename: Zhenghao
authors.initials: Z
authors.lastname: Shi
authors.affiliation: From the Department of Neurology, the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China (S.Y., H.H., X.Z., S.Z., M.L.); Department of Neurology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China (Z.S.); and University of California-Los Angeles Stroke Center (D.S.L.).
authors.forename: Xuting
authors.initials: X
authors.lastname: Zhang
authors.affiliation: From the Department of Neurology, the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China (S.Y., H.H., X.Z., S.Z., M.L.); Department of Neurology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China (Z.S.); and University of California-Los Angeles Stroke Center (D.S.L.).
authors.forename: Sheng
authors.initials: S
authors.lastname: Zhang
authors.affiliation: From the Department of Neurology, the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China (S.Y., H.H., X.Z., S.Z., M.L.); Department of Neurology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China (Z.S.); and University of California-Los Angeles Stroke Center (D.S.L.).
authors.forename: David S
authors.initials: DS
authors.lastname: Liebeskind
authors.affiliation: From the Department of Neurology, the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China (S.Y., H.H., X.Z., S.Z., M.L.); Department of Neurology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China (Z.S.); and University of California-Los Angeles Stroke Center (D.S.L.). loumingxc@vip.sina.com.
authors.forename: Min
authors.initials: M
authors.lastname: Lou
mesh_terms: D061605:Administration, Intravenous; D000368:Aged; D005260:Female; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000033:anatomy & histology / Q000503:physiopathology*; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D015912:Thrombolytic Therapy / Q000379:methods*; D016896:Treatment Outcome
keywords: magnetic resonance imaging; middle cerebral artery; stroke; thrombolytic therapy