title: Live free or die: cell-cell adhesion regulates sensitivity to trail-induced apoptosis.
abstract: The ability of the death ligand TRAIL to induce tumor cell apoptosis has led to the development of TRAIL-based cancer therapies. Reporting recently in Molecular Cell, Lu et al. (2014) show that the basis for differential TRAIL responses involves clustering of death receptor complexes by E-cadherin and the actin cytoskeleton.
authors.affiliation: Department of Cell Biology, Ludwig Center at Harvard, Boston, MA 02115, USA.
authors.forename: Lisa L
authors.initials: LL
authors.lastname: Gallegos
authors.affiliation: Department of Cell Biology, Ludwig Center at Harvard, Boston, MA 02115, USA. Electronic address: joan_brugge@hms.harvard.edu.
authors.forename: Joan S
authors.initials: JS
authors.lastname: Brugge
mesh_terms: D015703:Antigens, CD; D017209:Apoptosis / Q000502:physiology*; D015820:Cadherins / Q000378:metabolism*; D058750:Epithelial-Mesenchymal Transition / Q000502:physiology*; D006801:Humans; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand / Q000378:metabolism*
chemical_list: D015703:Antigens, CD; C513384:CDH1 protein, human; D015820:Cadherins; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand; C105190:TNFRSF10A protein, human