title: Asymptomatic intestinal amebiasis in Japanese HIV-1-infected individuals.
abstract: Seventy-one asymptomatic human immunodeficiency virus-1 (HIV-1) -infected individuals who underwent colonoscopy for detection of diseases other than amebiasis were included in this study. Ulcerative lesions caused by Entamoeba histolytica were identified by colonoscopy and biopsy in 11.3% (8 of 71) of individuals. Stool microscopic examination hardly identified Entamoeba, whereas serum antibody against E. histolytica was often elevated in patients with subclinical intestinal amebiasis. Human leukocyte antigen (HLA) class II allele against E. histolytica infection (DQB1*06:01) was frequently identified in these patients. This study emphasizes the endemic nature of E. histolytica infection in our cohort and the difficulties in epidemiological control.
authors.affiliation: AIDS Clinical Center, Department of Gastroenterology and Hepatology, and Pathology Division of Clinical Laboratory, National Center for Global Health and Medicine, Tokyo, Japan; Center for AIDS Research, Kumamoto University, Kumamoto, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Watanabe
authors.affiliation: AIDS Clinical Center, Department of Gastroenterology and Hepatology, and Pathology Division of Clinical Laboratory, National Center for Global Health and Medicine, Tokyo, Japan; Center for AIDS Research, Kumamoto University, Kumamoto, Japan.
authors.forename: Naoyoshi
authors.initials: N
authors.lastname: Nagata
authors.affiliation: AIDS Clinical Center, Department of Gastroenterology and Hepatology, and Pathology Division of Clinical Laboratory, National Center for Global Health and Medicine, Tokyo, Japan; Center for AIDS Research, Kumamoto University, Kumamoto, Japan.
authors.forename: Katsunori
authors.initials: K
authors.lastname: Sekine
authors.affiliation: AIDS Clinical Center, Department of Gastroenterology and Hepatology, and Pathology Division of Clinical Laboratory, National Center for Global Health and Medicine, Tokyo, Japan; Center for AIDS Research, Kumamoto University, Kumamoto, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Watanabe
authors.affiliation: AIDS Clinical Center, Department of Gastroenterology and Hepatology, and Pathology Division of Clinical Laboratory, National Center for Global Health and Medicine, Tokyo, Japan; Center for AIDS Research, Kumamoto University, Kumamoto, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Igari
authors.affiliation: AIDS Clinical Center, Department of Gastroenterology and Hepatology, and Pathology Division of Clinical Laboratory, National Center for Global Health and Medicine, Tokyo, Japan; Center for AIDS Research, Kumamoto University, Kumamoto, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Tanuma
authors.affiliation: AIDS Clinical Center, Department of Gastroenterology and Hepatology, and Pathology Division of Clinical Laboratory, National Center for Global Health and Medicine, Tokyo, Japan; Center for AIDS Research, Kumamoto University, Kumamoto, Japan.
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Kikuchi
authors.affiliation: AIDS Clinical Center, Department of Gastroenterology and Hepatology, and Pathology Division of Clinical Laboratory, National Center for Global Health and Medicine, Tokyo, Japan; Center for AIDS Research, Kumamoto University, Kumamoto, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Oka
authors.affiliation: AIDS Clinical Center, Department of Gastroenterology and Hepatology, and Pathology Division of Clinical Laboratory, National Center for Global Health and Medicine, Tokyo, Japan; Center for AIDS Research, Kumamoto University, Kumamoto, Japan higatana@acc.ncgm.go.jp.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Gatanaga
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000913:Antibodies, Protozoan / Q000097:blood; D058070:Asymptomatic Diseases; D001706:Biopsy; D015331:Cohort Studies; D003113:Colonoscopy; D003430:Cross-Sectional Studies; D004748:Entamoeba histolytica / Q000276:immunology / Q000302:isolation & purification*; D004749:Entamoebiasis / Q000150:complications* / Q000276:immunology / Q000469:parasitology; D005243:Feces / Q000469:parasitology; D005260:Female; D005787:Gene Frequency; D015658:HIV Infections / Q000150:complications* / Q000276:immunology / Q000821:virology; D015497:HIV-1 / Q000302:isolation & purification*; D059866:HLA-DQ beta-Chains / Q000097:blood / Q000235:genetics; D006801:Humans; D007410:Intestinal Diseases / Q000150:complications* / Q000276:immunology / Q000469:parasitology; D007564:Japan; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D014456:Ulcer / Q000150:complications* / Q000453:epidemiology / Q000469:parasitology
chemical_list: D000913:Antibodies, Protozoan; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen