title: Lacosamide-induced rash.
abstract: Cutaneous eruptions and hypersensitivity represent frequently reported side effects of anti-seizure medications. However, these side-effects have rarely been previously reported for lacosamide, a newer-generation anti-seizure medication with a novel mechanism of action. Here, we report a case of diffuse skin eruption in a patient with history of epilepsy soon after initiation of lacosamide. The rash resolved after discontinuation of lacosamide and use of antihistamines and steroids. We also review the information on drug hypersensitivity syndrome.
authors.affiliation: Department of Neurology.
authors.forename: Mohamad Z
authors.initials: MZ
authors.lastname: Koubeissi
authors.affiliation: Department of Neurology.
authors.forename: Marta
authors.initials: M
authors.lastname: Vismer
authors.affiliation: Department of Dermatology, George Washington University, Washington DC, USA.
authors.forename: Alison
authors.initials: A
authors.lastname: Ehrlich
mesh_terms: D000081:Acetamides / Q000009:adverse effects* / Q000627:therapeutic use; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D004827:Epilepsy / Q000188:drug therapy*; D005076:Exanthema / Q000139:chemically induced*; D005260:Female; D006801:Humans; D000078334:Lacosamide
chemical_list: D000081:Acetamides; D000927:Anticonvulsants; D000078334:Lacosamide
keywords: allergic; lacosamide; rash