title: Pea3 transcription factor promotes neurite outgrowth.
abstract: Pea3 subfamily of E-twenty six transcription factors consist of three major -exhibit branching morphogenesis, the function of Pea3 family in nervous system development and regeneration is only beginning to unfold. In this study, we provide evidence that Pea3 can directs neurite extension and axonal outgrowth in different model systems, and that Serine 90 is important for this function. We have also identified neurofilament-L and neurofilament-M as two putative novel targets for Pea3.
authors.affiliation: Molecular Neurobiology Laboratory, Department of Genetics and Bioengineering, Yeditepe University Istanbul, Turkey.
authors.forename: Basak
authors.initials: B
authors.lastname: Kandemir
authors.affiliation: Molecular Neurobiology Laboratory, Department of Genetics and Bioengineering, Yeditepe University Istanbul, Turkey ; Division of Neuroanatomy, Innsbruck Medical University Innsbruck, Austria.
authors.forename: Berrak
authors.initials: B
authors.lastname: Caglayan
authors.affiliation: Division of Neuroanatomy, Innsbruck Medical University Innsbruck, Austria.
authors.forename: Barbara
authors.initials: B
authors.lastname: Hausott
authors.affiliation: Molecular Neurobiology Laboratory, Department of Genetics and Bioengineering, Yeditepe University Istanbul, Turkey.
authors.forename: Burcu
authors.initials: B
authors.lastname: Erdogan
authors.affiliation: Molecular Neurobiology Laboratory, Department of Genetics and Bioengineering, Yeditepe University Istanbul, Turkey.
authors.forename: Ugur
authors.initials: U
authors.lastname: Dag
authors.affiliation: Molecular Neurobiology Laboratory, Department of Genetics and Bioengineering, Yeditepe University Istanbul, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Demir
authors.affiliation: Molecular Neurobiology Laboratory, Department of Genetics and Bioengineering, Yeditepe University Istanbul, Turkey.
authors.forename: Melis S
authors.initials: MS
authors.lastname: Sogut
authors.affiliation: Division of Neuroanatomy, Innsbruck Medical University Innsbruck, Austria.
authors.forename: Lars
authors.initials: L
authors.lastname: Klimaschewski
authors.affiliation: Molecular Neurobiology Laboratory, Department of Genetics and Bioengineering, Yeditepe University Istanbul, Turkey.
authors.forename: Isil A
authors.initials: IA
authors.lastname: Kurnaz
keywords: Pea3; axonal outgrowth; neurofilaments; neuron; phosphorylation