title: Terpenoids from Tripterygium hypoglaucum and their inhibition of LPS-induced NO production.
abstract: One new (1) and three known (2-4) sesquiterpenes and four known diterpenes (5-8) were isolated from the root bark of Tripterygium hypoglaucum. Their structures were elucidated on the basis of extensive spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, 1D-NMR, and 2D-NMR). The inhibitory activity toward LPS-induced NO production of these terpenoids was evaluated, all the compounds showing inhibitory effects.
authors.affiliation: a Tianjin Children's Hospital , Tianjin , China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhao
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.forename: Da-Qing
authors.initials: DQ
authors.lastname: Jin
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ohizumi
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.forename: Yuanqiang
authors.initials: Y
authors.lastname: Guo
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry; D008070:Lipopolysaccharides / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis* / Q000378:metabolism; D018517:Plant Roots / Q000737:chemistry; D012717:Sesquiterpenes / Q000008:administration & dosage / Q000737:chemistry* / Q000302:isolation & purification; D013729:Terpenes / Q000008:administration & dosage / Q000737:chemistry* / Q000302:isolation & purification; D029757:Tripterygium / Q000737:chemistry
chemical_list: D004365:Drugs, Chinese Herbal; D008070:Lipopolysaccharides; D012717:Sesquiterpenes; D013729:Terpenes; D009569:Nitric Oxide
keywords: NO production; Tripterygium hypoglaucum; terpenoid