title: Computer-aided image analysis algorithm to enhance in vivo diagnosis of plaque erosion by intravascular optical coherence tomography.
abstract: BACKGROUND
  Recent reports show that plaque erosion can be diagnosed in vivo using optical coherence tomography in patients with acute coronary syndrome. However, quantitative optical coherence tomographic image criteria for computer-aided diagnosis of plaque erosion have not been established.
  
  
  RESULTS
  A total of 42 patients with acute coronary syndrome caused by plaque erosion were included. Plaque erosion was identified according to the previously established optical coherence tomography criteria. Both optical properties and morphological features of the focal-eroded region as well as erosion-adjacent region were analyzed using a custom-designed computer algorithm. Noneroded fibrous plaques remote from the erosion site within the same vessel were used as controls. Eroded plaques have significantly lower surface intensity (P<0.001), lower region of interest intensity (P<0.001), lower surface normalized SD (P<0.001), lower region of interest normalized SD (P<0.001), higher optical attenuation (P<0.001), larger tissue protrusion area (P<0.001), and greater surface roughness (P<0.001) when compared with control plaques. Erosion-adjacent regions also have lower region of interest normalized SD (P=0.008), higher attenuation (P<0.001), and greater surface roughness (P=0.005). Using a logistic regression model built on the quantitative features, plaque erosion can be accurately classified against intact fibrous plaques. There was low inter- and intraobserver variability associated with the algorithm-assisted quantitative assessment.
  
  
  CONCLUSIONS
  Plaque erosion has distinctive optical properties and morphological features when compared with noneroded fibrous plaques. Quantitative image analysis may enhance diagnostic accuracy for plaque erosion in vivo.
authors.affiliation: From the Research Laboratory of Electronics, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge (Z.W., J.G.F.); Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China (H.J., J.T.); and Cardiology Division, Massachusetts General Hospital (H.J., J.T., T.S., R.V., Y.M., A.A., I.-K.J.), MGH Biostatistics Center, Massachusetts General Hospital (H.L.), and Cardiology Division, Brigham and Women's Hospital (A.A.), Harvard Medical School, Boston, MA.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Wang
authors.affiliation: From the Research Laboratory of Electronics, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge (Z.W., J.G.F.); Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China (H.J., J.T.); and Cardiology Division, Massachusetts General Hospital (H.J., J.T., T.S., R.V., Y.M., A.A., I.-K.J.), MGH Biostatistics Center, Massachusetts General Hospital (H.L.), and Cardiology Division, Brigham and Women's Hospital (A.A.), Harvard Medical School, Boston, MA.
authors.forename: Haibo
authors.initials: H
authors.lastname: Jia
authors.affiliation: From the Research Laboratory of Electronics, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge (Z.W., J.G.F.); Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China (H.J., J.T.); and Cardiology Division, Massachusetts General Hospital (H.J., J.T., T.S., R.V., Y.M., A.A., I.-K.J.), MGH Biostatistics Center, Massachusetts General Hospital (H.L.), and Cardiology Division, Brigham and Women's Hospital (A.A.), Harvard Medical School, Boston, MA.
authors.forename: Jinwei
authors.initials: J
authors.lastname: Tian
authors.affiliation: From the Research Laboratory of Electronics, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge (Z.W., J.G.F.); Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China (H.J., J.T.); and Cardiology Division, Massachusetts General Hospital (H.J., J.T., T.S., R.V., Y.M., A.A., I.-K.J.), MGH Biostatistics Center, Massachusetts General Hospital (H.L.), and Cardiology Division, Brigham and Women's Hospital (A.A.), Harvard Medical School, Boston, MA.
authors.forename: Tsunenari
authors.initials: T
authors.lastname: Soeda
authors.affiliation: From the Research Laboratory of Electronics, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge (Z.W., J.G.F.); Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China (H.J., J.T.); and Cardiology Division, Massachusetts General Hospital (H.J., J.T., T.S., R.V., Y.M., A.A., I.-K.J.), MGH Biostatistics Center, Massachusetts General Hospital (H.L.), and Cardiology Division, Brigham and Women's Hospital (A.A.), Harvard Medical School, Boston, MA.
authors.forename: Rocco
authors.initials: R
authors.lastname: Vergallo
authors.affiliation: From the Research Laboratory of Electronics, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge (Z.W., J.G.F.); Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China (H.J., J.T.); and Cardiology Division, Massachusetts General Hospital (H.J., J.T., T.S., R.V., Y.M., A.A., I.-K.J.), MGH Biostatistics Center, Massachusetts General Hospital (H.L.), and Cardiology Division, Brigham and Women's Hospital (A.A.), Harvard Medical School, Boston, MA.
authors.forename: Yoshiyasu
authors.initials: Y
authors.lastname: Minami
authors.affiliation: From the Research Laboratory of Electronics, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge (Z.W., J.G.F.); Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China (H.J., J.T.); and Cardiology Division, Massachusetts General Hospital (H.J., J.T., T.S., R.V., Y.M., A.A., I.-K.J.), MGH Biostatistics Center, Massachusetts General Hospital (H.L.), and Cardiology Division, Brigham and Women's Hospital (A.A.), Harvard Medical School, Boston, MA.
authors.forename: Hang
authors.initials: H
authors.lastname: Lee
authors.affiliation: From the Research Laboratory of Electronics, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge (Z.W., J.G.F.); Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China (H.J., J.T.); and Cardiology Division, Massachusetts General Hospital (H.J., J.T., T.S., R.V., Y.M., A.A., I.-K.J.), MGH Biostatistics Center, Massachusetts General Hospital (H.L.), and Cardiology Division, Brigham and Women's Hospital (A.A.), Harvard Medical School, Boston, MA.
authors.forename: Aaron
authors.initials: A
authors.lastname: Aguirre
authors.affiliation: From the Research Laboratory of Electronics, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge (Z.W., J.G.F.); Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China (H.J., J.T.); and Cardiology Division, Massachusetts General Hospital (H.J., J.T., T.S., R.V., Y.M., A.A., I.-K.J.), MGH Biostatistics Center, Massachusetts General Hospital (H.L.), and Cardiology Division, Brigham and Women's Hospital (A.A.), Harvard Medical School, Boston, MA.
authors.forename: James G
authors.initials: JG
authors.lastname: Fujimoto
authors.affiliation: From the Research Laboratory of Electronics, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge (Z.W., J.G.F.); Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China (H.J., J.T.); and Cardiology Division, Massachusetts General Hospital (H.J., J.T., T.S., R.V., Y.M., A.A., I.-K.J.), MGH Biostatistics Center, Massachusetts General Hospital (H.L.), and Cardiology Division, Brigham and Women's Hospital (A.A.), Harvard Medical School, Boston, MA. ijang@partners.org.
authors.forename: Ik-Kyung
authors.initials: IK
authors.lastname: Jang
mesh_terms: D054058:Acute Coronary Syndrome / Q000175:diagnosis* / Q000209:etiology; D000465:Algorithms; D003331:Coronary Vessels / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D041623:Tomography, Optical Coherence / Q000379:methods*; D018084:Ultrasonography, Interventional / Q000379:methods*
keywords: acute coronary syndrome; tomography, optical coherence