title: Polymorphisms in TLR1, TLR6 and TLR10 genes and the risk of Graves' disease.
abstract: Graves' disease (GD) is postulated to be caused by the combined effects of susceptibility genes and environmental triggers. Toll-like receptors (TLRs) play a role in the activation of innate and adaptive immune responses in mammalians. The aim of this study was to evaluate the potential association of polymorphisms in TLR1, TLR6 and TLR10 genes with GD in Chinese Cantonese population. Seven single nucleotide polymorphisms (i.e. rs4833095 and rs5743565 in TLR1; rs5743808 in TLR6; and rs4504265, rs11466655, rs11096957 and rs10856839 in TLR10) were evaluated in 332 GD patients and 351 unrelated controls from Chinese Cantonese population. SNP rs5743565 in TLR1 conferred a protective effect against GD. The minor allele G of rs5743565 decreased the risk of GD in all cases (odds ratio; ORG vs. A=0.72 (0.58-0.91); p=0.005; ptrend=0.004) and early onset patients (ORG vs. A=0.72 (0.56-0.91); p=0.007; ptrend=0.006). This study provided evidence that genetic variation rs5743565 in TLR1 might be associated with the decreased susceptibility of GD.
authors.affiliation: Research Center for Molecular Biology, College of Life Science and Technology, Jinan University , Guangzhou , P.R. China and.
authors.forename: WenJuan
authors.initials: W
authors.lastname: Xiao
authors.forename: ZeLin
authors.initials: Z
authors.lastname: Liu
authors.forename: JiangHai
authors.initials: J
authors.lastname: Lin
authors.forename: JingBo
authors.initials: J
authors.lastname: Li
authors.forename: KeJing
authors.initials: K
authors.lastname: Wu
authors.forename: Yun
authors.initials: Y
authors.lastname: Ma
authors.forename: YingXue
authors.initials: Y
authors.lastname: Gong
authors.forename: ZeHuan
authors.initials: Z
authors.lastname: Liu
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D015870:Gene Expression; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006111:Graves Disease / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D005810:Multigene Family; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D051194:Toll-Like Receptor 1 / Q000235:genetics* / Q000276:immunology; D051201:Toll-Like Receptor 10 / Q000235:genetics* / Q000276:immunology; D051216:Toll-Like Receptor 6 / Q000235:genetics* / Q000276:immunology
chemical_list: C475955:TLR10 protein, human; C495368:TLR6 protein, human; D051194:Toll-Like Receptor 1; D051201:Toll-Like Receptor 10; D051216:Toll-Like Receptor 6
keywords: Association; Graves’ disease; Toll like receptor; case-control study; single nucleotide polymorphisms