title: Influence of the c.1517G>C genetic variant in the XRCC1 gene on pancreatic cancer susceptibility in a Chinese population.
abstract: We investigated the influence of the c.1517G>C genetic variant in the X-ray repair complementing group 1 gene (XRCC1) on pancreatic cancer (PC) susceptibility in Chinese patients. A total of 390 PC patients and 392 controls were enrolled in this case-control study. The genotypes of c.1517G>C genetic variants were determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Our findings suggested that the allele and genotype frequencies in PC patients were significantly different from those in cancer-free controls. The CC genotype was associated with an increased risk of PC compared to the wild-type GG genotype (odds ratio=2.43, 95% confidence interval 1.43-4.13, X2=11.19, P=0.001). The C allele may contribute to the development of PC (C vs G, odds ratio=1.32, 95% confidence interval 1.06-1.64, X2=6.25, P=0.012). Results from this study indicate that the c.1517G>C genetic variant of the XRCC1 gene is significantly associated with PC susceptibility in the Chinese population.
authors.affiliation: Department of Surgical Oncology, The Chinese PLA General Hospital, Beijing, China zhi_ming_zhao@sina.com.
authors.forename: Z M
authors.initials: ZM
authors.lastname: Zhao
authors.affiliation: Department of Surgical Oncology, The Chinese PLA General Hospital, Beijing, China.
authors.forename: C G
authors.initials: CG
authors.lastname: Li
authors.affiliation: Department of Surgical Oncology, The Chinese PLA General Hospital, Beijing, China.
authors.forename: M G
authors.initials: MG
authors.lastname: Hu
authors.affiliation: Department of Surgical Oncology, The Chinese PLA General Hospital, Beijing, China.
authors.forename: Y X
authors.initials: YX
authors.lastname: Gao
authors.affiliation: Department of Surgical Oncology, The Chinese PLA General Hospital, Beijing, China.
authors.forename: R
authors.initials: R
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human