title: A multisite study of the relationships between blast exposures and symptom reporting in a post-deployment active duty military population with mild traumatic brain injury.
abstract: Explosive devices have been the most frequent cause of traumatic brain injury (TBI) among deployed contemporary U.S. service members. The purpose of this study was to examine the influence of previous cumulative blast exposures (that did or did not result in TBI) on later post-concussion and post-traumatic symptom reporting after sustaining a mild TBI (MTBI). Participants were 573 service members who sustained MTBI divided into four groups by number of blast exposures (1, 2, 3, and 4-10) and a nonblast control group. Post-concussion symptoms were measured using the Neurobehavioral Symptom Inventory (NSI) and post-traumatic stress disorder (PTSD) symptoms using the Post-traumatic Checklist-Civilian version (PCL-C). Results show groups significantly differed on total NSI scores (p<0.001), where symptom endorsement increased as number of reported blast exposures increased. Total NSI scores were significantly higher for the 3- and 4-10 blast groups compared with the 1- and 2-blast groups with effect sizes ranging from small to moderate (d=0.31 to 0.63). After controlling for PTSD symptoms using the PCL-C total score, NSI total score differences remained between the 4-10-blast group and the 1- and 2-blast groups, but were less pronounced (d=0.35 and d=0.24, respectively). Analyses of NSI subscale scores using PCL-C scores as a covariate revealed significant between-blast group differences on cognitive, sensory, and somatic, but not affective symptoms. Regression analyses revealed that cumulative blast exposures accounted for a small but significant amount of the variance in total NSI scores (4.8%; p=0.009) and total PCL-C scores (2.3%; p<0.001). Among service members exposed to blast, post-concussion symptom reporting increased as a function of cumulative blast exposures. Future research will need to determine the relationship between cumulative blast exposures, symptom reporting, and neuropathological changes.
authors.affiliation: 1 Defense and Veterans Brain Injury Center , Silver Spring, Maryland.
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Reid
authors.forename: Kelly J
authors.initials: KJ
authors.lastname: Miller
authors.forename: Rael T
authors.initials: RT
authors.lastname: Lange
authors.forename: Douglas B
authors.initials: DB
authors.lastname: Cooper
authors.forename: David F
authors.initials: DF
authors.lastname: Tate
authors.forename: Jason
authors.initials: J
authors.lastname: Bailie
authors.forename: Tracey A
authors.initials: TA
authors.lastname: Brickell
authors.forename: Louis M
authors.initials: LM
authors.lastname: French
authors.forename: Sarah
authors.initials: S
authors.lastname: Asmussen
authors.forename: Jan E
authors.initials: JE
authors.lastname: Kennedy
mesh_terms: D000328:Adult; D001753:Blast Injuries / Q000150:complications*; D001924:Brain Concussion / Q000175:diagnosis / Q000209:etiology; D001930:Brain Injuries / Q000175:diagnosis* / Q000209:etiology; D005107:Explosions; D006801:Humans; D008297:Male; D008889:Military Personnel; D038223:Post-Concussion Syndrome / Q000175:diagnosis* / Q000209:etiology; D013313:Stress Disorders, Post-Traumatic / Q000175:diagnosis* / Q000209:etiology; D063189:Symptom Assessment; D055815:Young Adult
keywords: blast; mild traumatic brain injury; neurobehavioral symptom inventory; post-concussion; post-traumatic stress