title: Ubiquitination involved enzymes and cancer.
abstract: Ubiquitination is a post-translational modification process that regulates multiple cell functions. It also plays important roles in the development of cancer. Mechanistically, ubiquitination is a complex process that is comprised of a series of events involving ubiquitin-activating enzymes, ubiquitin-conjugating enzymes and ubiquitin ligases. In general, covalent attachment of ubiquitin to the target proteins marks them for degradation. Dysregulation of the ubiquitination process may cause carcinogenesis. In this review, we summarize recent developments in understanding the relationship between ubiquitination enzymes and carcinogenesis.
authors.affiliation: Department of Biochemistry, School of Life Sciences, Central South University, Changsha, 410013, Hunan, China, lightningzhou@163.com.
authors.forename: Mei-juan
authors.initials: MJ
authors.lastname: Zhou
authors.forename: Fang-zhi
authors.initials: FZ
authors.lastname: Chen
authors.forename: Han-chun
authors.initials: HC
authors.lastname: Chen
mesh_terms: D019313:BRCA1 Protein / Q000378:metabolism; D056827:Endosomal Sorting Complexes Required for Transport / Q000378:metabolism; D004798:Enzymes / Q000378:metabolism*; D006801:Humans; D000075702:Nedd4 Ubiquitin Protein Ligases; D009369:Neoplasms / Q000378:metabolism*; D044843:SKP Cullin F-Box Protein Ligases / Q000378:metabolism; D044764:Ubiquitin-Activating Enzymes / Q000378:metabolism; D044763:Ubiquitin-Conjugating Enzymes / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism; D054875:Ubiquitination; D051794:Von Hippel-Lindau Tumor Suppressor Protein / Q000378:metabolism
chemical_list: D019313:BRCA1 Protein; C492913:BRCA1 protein, human; D056827:Endosomal Sorting Complexes Required for Transport; D004798:Enzymes; D044763:Ubiquitin-Conjugating Enzymes; D000075702:Nedd4 Ubiquitin Protein Ligases; D044843:SKP Cullin F-Box Protein Ligases; D044767:Ubiquitin-Protein Ligases; D051794:Von Hippel-Lindau Tumor Suppressor Protein; D044764:Ubiquitin-Activating Enzymes; C497446:VHL protein, human