title: Uncommon chlorinated xanthone and other antibacterial compounds from the lichen Cladonia incrassata.
abstract: Bioassay-guided fractionation of an extract of the lichen Cladonia incrassata against Staphylococcus aureus led to a novel compound, 1,5-dihydroxy-2,4,6-trichloro-7-methylxanthone (1), along with six known compounds: (-)-usnic acid (2), didymic acid (3), condidymic acid (4), squamatic acid (5), thamnolic acid (6), and prasinic acid (7). Didymic, condidymic, and prasinic acids were isolated for the first time from C. incrassata. Didymic, condidymic, and (-)-usnic acids were active against S. aureus (a minimum inhibitory concentration of 7.5 µg/mL).
authors.affiliation: Laboratoire de Chimie des Substances Naturelles (EA 1069), Faculté de Pharmacie, Université de Limoges, Limoges, France.
authors.forename: Amandine
authors.initials: A
authors.lastname: Dieu
authors.affiliation: Laboratoire de Chimie des Substances Naturelles (EA 1069), Faculté de Pharmacie, Université de Limoges, Limoges, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Millot
authors.affiliation: Service Commun de Recherche et d'Analyse des Biomolécules de Limoges, Faculté de Pharmacie, Université de Limoges, Limoges, France.
authors.forename: Yves
authors.initials: Y
authors.lastname: Champavier
authors.affiliation: Laboratoire de Chimie des Substances Naturelles (EA 1069), Faculté de Pharmacie, Université de Limoges, Limoges, France.
authors.forename: Lengo
authors.initials: L
authors.lastname: Mambu
authors.affiliation: Laboratoire de Chimie des Substances Naturelles (EA 1069), Faculté de Pharmacie, Université de Limoges, Limoges, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Chaleix
authors.affiliation: Laboratoire de Chimie des Substances Naturelles (EA 1069), Faculté de Pharmacie, Université de Limoges, Limoges, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Sol
authors.affiliation: Laboratoire de Chimie des Substances Naturelles (EA 1069), Faculté de Pharmacie, Université de Limoges, Limoges, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Gloaguen
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D054879:Halogenation; D008011:Lichens / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000187:drug effects; D014966:Xanthenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D001572:Benzofurans; D014966:Xanthenes; D044004:Xanthones; C000597142:cladoxanthone A; C073339:usnic acid; C009689:xanthone