title: Diphenyl ethers from Aspergillus sp. and their anti-Aβ₄₂ aggregation activities.
abstract: Two new compounds with the character of diphenyl ether structure, oxisterigmatocystin D (1) and 9-acetyldiorcinol B (6), were isolated from the endolichenic fungal strain Aspergillus sp. (No. 16-20-8-1), along with six known compounds, oxisterigmatocystin A (2), oxisterigmatocystin C (3), sterigmatocystin (4), diorcinol B (5), violaceol-I (7), and violaceol-II (8). The structures of the new compounds were determined by extensive NMR spectroscopic data, and the absolute configuration of 1 was established by single-crystal X-ray diffraction analysis. Moreover, the Aβ42 aggregation inhibitory activities of 5-8 were evaluated by the standard thioflavin T (ThT) fluorescence assay using epigallocatechin gallate (EGCG) as the positive control. Compounds 7 and 8 displayed significant anti-Aβ42 aggregation activity with IC50 values of 5.1 and 2.3μM, respectively. Preliminary structure-activity relationship of these diphenyl ethers as anti-Aβ42 aggregation inhibitors was proposed.
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
authors.forename: Huan
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
authors.forename: Gao-Qian
authors.initials: GQ
authors.lastname: Wang
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
authors.forename: Xu-Peng
authors.initials: XP
authors.lastname: Tong
authors.affiliation: Department of Pharmaceutical Engineering, College of Natural Resources and Environment, South China Agricultural University, Guangzhou 510642, People's Republic of China. Electronic address: chgdtong@163.com.
authors.forename: Guo-Dong
authors.initials: GD
authors.lastname: Chen
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
authors.forename: Yuan-Fan
authors.initials: YF
authors.lastname: Huang
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
authors.forename: Jia-Yu
authors.initials: JY
authors.lastname: Cui
authors.affiliation: Shenzhen Key Laboratory of Microbial Genetic Engineering, College of Life Sciences, Shenzhen University, Shenzhen 518060, People's Republic of China.
authors.forename: Ming-Zhu
authors.initials: MZ
authors.lastname: Kong
authors.affiliation: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.
authors.forename: Liang-Dong
authors.initials: LD
authors.lastname: Guo
authors.affiliation: Shenzhen Key Laboratory of Microbial Genetic Engineering, College of Life Sciences, Shenzhen University, Shenzhen 518060, People's Republic of China.
authors.forename: Yi-Zhi
authors.initials: YZ
authors.lastname: Zheng
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
authors.forename: Xin-Sheng
authors.initials: XS
authors.lastname: Yao
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China. Electronic address: tghao@jnu.edu.cn.
authors.forename: Hao
authors.initials: H
authors.lastname: Gao
mesh_terms: D016229:Amyloid beta-Peptides / Q000737:chemistry*; D001230:Aspergillus / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010446:Peptide Fragments / Q000737:chemistry*; D010647:Phenyl Ethers / Q000737:chemistry* / Q000302:isolation & purification; D066329:Protein Aggregates / Q000187:drug effects; D066263:Protein Aggregation, Pathological / Q000517:prevention & control; D013329:Structure-Activity Relationship
chemical_list: C000597496:9-acetyldiorcinol B; D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; D010647:Phenyl Ethers; D066329:Protein Aggregates; C075222:amyloid beta-protein (1-42); C000597495:oxisterigmatocystin D
keywords: Anti-Aβ(42) aggregation activity; Aspergillus sp.; Diphenyl ethers