title: RhoA mutations identified in diffuse gastric cancer.
abstract: The diffuse-type histologic variant of gastric cancer is characterized by highly invasive growth patterns and lack of cellular cohesion. Two recent studies have identified highly recurrent mutations of the gene encoding the small GTPase RhoA and suggest that RhoA activity may have a tumor suppressive role in this disease.
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
authors.forename: Jin
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Division of Digestive and Liver Diseases and Herbert Irving Cancer Research Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
authors.forename: Yoku
authors.initials: Y
authors.lastname: Hayakawa
authors.affiliation: Division of Digestive and Liver Diseases and Herbert Irving Cancer Research Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. Electronic address: tcw21@columbia.edu.
authors.forename: Timothy C
authors.initials: TC
authors.lastname: Wang
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address: adam_bass@dfci.harvard.edu.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Bass
mesh_terms: D023102:Anoikis; D002454:Cell Differentiation; D020022:Genetic Predisposition to Disease; D006801:Humans; D009154:Mutation; D009361:Neoplasm Invasiveness; D010641:Phenotype; D011379:Prognosis; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000235:genetics* / Q000473:pathology; D020742:rhoA GTP-Binding Protein / Q000235:genetics* / Q000378:metabolism
chemical_list: C066737:RHOA protein, human; D020742:rhoA GTP-Binding Protein