title: Role of training and detraining on inflammatory and metabolic profile in infarcted rats: influences of cardiovascular autonomic nervous system.
abstract: The aim of this study was to evaluate the effects of exercise training (ET, 50-70% of VO2 max, 5 days/week) and detraining (DT) on inflammatory and metabolic profile after myocardial infarction (MI) in rats. Male Wistar rats were divided into control (C, n = 8), sedentary infarcted (SI, n = 9), trained infarcted (TI, n = 10; 3 months of ET), and detrained infarcted (DI, n = 11; 2 months of ET + 1 month of DT). After ET and DT protocols, ventricular function and inflammation, cardiovascular autonomic modulation (spectral analysis), and adipose tissue inflammation and lipolytic pathway were evaluated. ET after MI improved cardiac and vascular autonomic modulation, and these benefits were correlated with reduced inflammatory cytokines on the heart and adipose tissue. These positive changes were sustained even after 1 month of detraining. No expressive changes were observed in oxidative stress and lipolytic pathway in experimental groups. In conclusion, our results strongly suggest that the autonomic improvement promoted by ET, and maintained even after the detraining period, was associated with reduced inflammatory profile in the left ventricle and adipose tissue of rats subjected to MI. These data encourage enhancing cardiovascular autonomic function as a therapeutic strategy for the treatment of inflammatory process triggered by MI.
authors.affiliation: Human Movement Laboratory, Sao Judas Tadeu University (USJT), Avenida Taquari 546, 03166-000 São Paulo, SP, Brazil.
authors.forename: Bruno
authors.identifier: 0000-0003-4246-4703
authors.initials: B
authors.lastname: Rodrigues
authors.affiliation: Physiology Department, Nutrition Physiology Discipline, Federal University of São Paulo (UNIFESP), Rua Sena Madureira 1500, 04021-001 São Paulo, SP, Brazil.
authors.forename: Aline Alves
authors.initials: AA
authors.lastname: Santana
authors.affiliation: Physiology Department, Nutrition Physiology Discipline, Federal University of São Paulo (UNIFESP), Rua Sena Madureira 1500, 04021-001 São Paulo, SP, Brazil.
authors.forename: Aline Boveto
authors.initials: AB
authors.lastname: Santamarina
authors.affiliation: Physiology Department, Nutrition Physiology Discipline, Federal University of São Paulo (UNIFESP), Rua Sena Madureira 1500, 04021-001 São Paulo, SP, Brazil.
authors.forename: Lila Missae
authors.initials: LM
authors.lastname: Oyama
authors.affiliation: Human Movement Laboratory, Sao Judas Tadeu University (USJT), Avenida Taquari 546, 03166-000 São Paulo, SP, Brazil.
authors.forename: Érico Chagas
authors.initials: ÉC
authors.lastname: Caperuto
authors.affiliation: Laboratory of Exercise Physiology and Biochemistry, Universidade do Extremo Sul Catarinense (UNESC), Avenida Universitária 1105, 88806-000 Criciúma, SC, Brazil.
authors.forename: Cláudio Teodoro
authors.initials: CT
authors.lastname: de Souza
authors.affiliation: Human Movement Laboratory, Sao Judas Tadeu University (USJT), Avenida Taquari 546, 03166-000 São Paulo, SP, Brazil.
authors.forename: Catarina de Andrade
authors.initials: Cde A
authors.lastname: Barboza
authors.affiliation: Human Movement Laboratory, Sao Judas Tadeu University (USJT), Avenida Taquari 546, 03166-000 São Paulo, SP, Brazil.
authors.forename: Leandro Yanase
authors.initials: LY
authors.lastname: Rocha
authors.affiliation: Hypertension Unit, Heart Institute (InCor), Medical School of University of São Paulo, Avenida Doutor Enéas de Carvalho Aguiar 44, 05403-900 São Paulo, SP, Brazil.
authors.forename: Diego
authors.initials: D
authors.lastname: Figueroa
authors.affiliation: Hypertension Unit, Heart Institute (InCor), Medical School of University of São Paulo, Avenida Doutor Enéas de Carvalho Aguiar 44, 05403-900 São Paulo, SP, Brazil.
authors.forename: Cristiano
authors.initials: C
authors.lastname: Mostarda
authors.affiliation: Hypertension Unit, Heart Institute (InCor), Medical School of University of São Paulo, Avenida Doutor Enéas de Carvalho Aguiar 44, 05403-900 São Paulo, SP, Brazil.
authors.forename: Maria Cláudia
authors.initials: MC
authors.lastname: Irigoyen
authors.affiliation: Immunometabolism Research Group, Department of Physical Education, University of São Paulo State (UNESP), Rua Roberto Simonsen 305, 19060-900 Presidente Prudente, SP, Brazil.
authors.forename: Fábio Santos
authors.initials: FS
authors.lastname: Lira
mesh_terms: D000818:Animals; D001341:Autonomic Nervous System / Q000276:immunology* / Q000378:metabolism*; D006339:Heart Rate / Q000502:physiology; D007249:Inflammation / Q000276:immunology / Q000378:metabolism / Q000628:therapy; D008297:Male; D009203:Myocardial Infarction / Q000276:immunology* / Q000378:metabolism* / Q000628:therapy; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar