title: Reducing risks in type 1 diabetes using H∞ control.
abstract: A control scheme was designed in order to reduce the risks of hyperglycemia and hypoglycemia in type 1 diabetes mellitus (T1DM). This structure is composed of three main components: an H∞ robust controller, an insulin feedback loop (IFL), and a safety mechanism (SM). A control-relevant model that is employed to design the robust controller is identified. The identification procedure is based on the distribution version of the UVA/Padova metabolic simulator using the simulation adult cohort. The SM prevents dangerous scenarios by acting upon a prediction of future glucose levels, and the IFL modifies the loop gain in order to reduce postprandial hypoglycemia risks. The procedure is tested on the complete alic>in silico adult cohort of the UVA/Padova metabolic simulator, which has been accepted by the Food and Drug Administration (FDA) in lieu of animal trials.
authors.forename: Patricio
authors.initials: P
authors.lastname: Colmegna
authors.forename: Ricardo S
authors.initials: RS
authors.lastname: Sanchez Pena
authors.forename: Ravi
authors.initials: R
authors.lastname: Gondhalekar
authors.forename: Eyal
authors.initials: E
authors.lastname: Dassau
authors.forename: Francis J
authors.initials: FJ
authors.lastname: Doyle Iii
mesh_terms: D000328:Adult; D000465:Algorithms; D001786:Blood Glucose / Q000378:metabolism*; D003198:Computer Simulation; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy*; D004360:Drug Therapy, Computer-Assisted / Q000379:methods*; D025461:Feedback, Physiological; D005260:Female; D006801:Humans; D007328:Insulin / Q000008:administration & dosage* / Q000097:blood*; D008297:Male; D008954:Models, Biological; D019397:Pancreas, Artificial; D015203:Reproducibility of Results; D040242:Risk Reduction Behavior; D012680:Sensitivity and Specificity
chemical_list: D001786:Blood Glucose; D007328:Insulin