title: Prenatal management and outcomes in mirror syndrome associated with twin-twin transfusion syndrome.
abstract: OBJECTIVE
  The aim of this article is to investigate the prevalence, clinical presentation, prenatal management, and prognosis of mirror syndrome associated with twin-twin transfusion syndrome (TTTS) treated by amnioreduction or selective fetocide.
  
  
  METHODS
  A retrospective study of twin pregnancies with TTTS was conducted. The prevalence of mirror syndrome, defined as severe maternal edema related to fetal hydrops and placental edema, was calculated for TTTS, and data on clinical characteristics, treatment, and outcomes of the patients were reviewed.
  
  
  RESULTS
  We observed mirror syndrome in 4.85% (5/103) of pregnancies with TTTS and 26.32% (5/19) of pregnancies with TTTS Stage IV. Most cases (4/5) of mirror syndrome associated with TTTS were diagnosed before 24 weeks of gestation. The patients manifested edema, anemia, hemodilution, and hypoproteinemia (5/5); proteinuria (4/5); complicated postpartum hemorrhage (4/5); and pulmonary edema and congestive heart failure (2/5). Maternal hemoglobin, hematocrit, and plasma protein dropped after amnioreduction. The perinatal survival rate at 28 days was 28.57% (2/7), and only one infant born after selective feticide survived beyond 18 months.
  
  
  CONCLUSIONS
  TTTS carries a high risk of mirror syndrome, a disease with significant materno-fetal mortality and morbidity. Amnioreduction alone or with selective feticide in mirror syndrome may transiently aggravate anemia and hemodilution and lead to severe maternal complications. © 2014 John Wiley & Sons, Ltd.
authors.affiliation: Fetal Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Hanjing
authors.initials: H
authors.lastname: Chai
authors.forename: Qun
authors.initials: Q
authors.lastname: Fang
authors.forename: Xuan
authors.initials: X
authors.lastname: Huang
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhou
authors.forename: Yanmin
authors.initials: Y
authors.lastname: Luo
mesh_terms: D002681:China / Q000453:epidemiology; D005260:Female; D005330:Fetofetal Transfusion / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D015995:Prevalence; D012189:Retrospective Studies