title: Photoactivatable fluorescein derivatives caged with a (3-hydroxy-2-naphthalenyl)methyl group.
abstract: The (3-hydroxy-2-naphthalenyl)methyl (NQMP) group represents an efficient photocage for fluorescein-based dyes. Thus, irradiation of the 6-NQMP ether of 2'-hydroxymethylfluorescein with low-intensity UVA light results in a 4-fold increase in emission intensity. Photoactivation of nonfluorescent NQMP-caged 3-allyloxyfluorescein produces a highly emissive fluorescein monoether. To facilitate conjugation of the caged dye to the substrate of interest via click chemistry, the allyloxy appendage was functionalized with an azide moiety.
authors.affiliation: Department of Chemistry, University of Georgia , Athens, Georgia 30602, United States.
authors.forename: Emmanuel E
authors.initials: EE
authors.lastname: Nekongo
authors.forename: Vladimir V
authors.initials: VV
authors.lastname: Popik
mesh_terms: D001386:Azides / Q000737:chemistry*; D057930:Click Chemistry; D019793:Fluorescein / Q000737:chemistry*; D008027:Light; D009281:Naphthalenes / Q000737:chemistry*; D010777:Photochemistry
chemical_list: C000595170:(3-hydroxy-2-naphthalenyl)methyl; D001386:Azides; D009281:Naphthalenes; D019793:Fluorescein