title: Efficacy of fecal microbiota transplantation in 2 children with recurrent Clostridium difficile infection and its impact on their growth and gut microbiome.
abstract: Fecal microbiota transplantation (FMT) is recognized as an alternative therapeutic modality for recurrent Clostridium difficile infection (RCDI); however, data on its efficacy in children are lacking, including its effect on their growth and fecal microbiota. We report on 2 young children (<3 years old) who failed available therapeutics for RCDI, but responded remarkably well to FMT. Besides resolution of clinical features of C difficile infection (CDI), FMT administration led to marked improvement in their growth, along with increased microbiota diversity, especially proportion of Bacteroides. Our 2 cases illustrate the efficacy of FMT in children with RCDI and its positive effect on their growth and gut microbiota.
authors.affiliation: *Division of Pediatric Gastroenterology, Department of Pediatrics, West Virginia University, Charleston †Division of Gastroenterology, Department of Medicine, Sinai Hospital Program in Internal Medicine ‡Institute for Genome Sciences, University of Maryland School of Medicine §Division of Pediatric Gastroenterology, Department of Pediatrics, Johns Hopkins University ||Division of Gastroenterology, Department of Medicine, Sinai Hospital, Baltimore, Maryland.
authors.forename: Ritu
authors.initials: R
authors.lastname: Walia
authors.forename: Shashank
authors.initials: S
authors.lastname: Garg
authors.forename: Yang
authors.initials: Y
authors.lastname: Song
authors.forename: Mohit
authors.initials: M
authors.lastname: Girotra
authors.forename: Carmen
authors.initials: C
authors.lastname: Cuffari
authors.forename: Wolfgang Florian
authors.initials: WF
authors.lastname: Fricke
authors.forename: Sudhir K
authors.initials: SK
authors.lastname: Dutta
mesh_terms: D001439:Bacteroides / Q000254:growth & development; D001691:Biological Therapy; D002675:Child, Preschool; D016360:Clostridioides difficile / Q000254:growth & development; D003015:Clostridium Infections / Q000382:microbiology / Q000628:therapy*; D005243:Feces / Q000382:microbiology*; D006128:Growth; D006801:Humans; D007223:Infant; D007422:Intestines / Q000382:microbiology*; D008297:Male; D064307:Microbiota; D016896:Treatment Outcome