title: Evolution of the mir-181 microRNA family.
abstract: Mir-181 is an ancient microRNA (miRNA) gene family that originated in urochordata. Although their functions were subjected to extensive studies in recent years, their evolutionary process remains largely unknown. Here we systematically investigated the homologous genes of the mir-181 family by a sequence similarity search. Representative sequences of the mir-181 gene family were used to reconstruct their evolutionary history. Our results indicated that this family could have derived from multiple duplications, which include two rounds of whole genome duplications and one round of segmental replication. Functional annotation of the target genes of the mir-181 family suggested that this family could participate in some important biological processes including transcriptional and translational regulation, signaling transduction etc. This analysis presented a complex evolutionary dynamics for the origination of a miRNA gene family.
authors.affiliation: Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science, CAMS & PUMC, 100730 Beijing, China; School of Life Sciences, Fudan University, Shanghai 200433, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science, CAMS & PUMC, 100730 Beijing, China.
authors.forename: Xueshuai
authors.initials: X
authors.lastname: Wan
authors.affiliation: School of Life Sciences, Fudan University, Shanghai 200433, China.
authors.forename: Zhuoya
authors.initials: Z
authors.lastname: Gu
authors.affiliation: Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science, CAMS & PUMC, 100730 Beijing, China.
authors.forename: Haohai
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science, CAMS & PUMC, 100730 Beijing, China.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science, CAMS & PUMC, 100730 Beijing, China.
authors.forename: Lian
authors.initials: L
authors.lastname: He
authors.affiliation: Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science, CAMS & PUMC, 100730 Beijing, China.
authors.forename: Ruoyu
authors.initials: R
authors.lastname: Miao
authors.affiliation: School of Life Sciences, Fudan University, Shanghai 200433, China; Institute of Biodiversity Science and Geobiology, Tibet University, Lhasa 850000, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhong
authors.affiliation: Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science, CAMS & PUMC, 100730 Beijing, China. Electronic address: zhaoht@pumch.cn.
authors.forename: Haitao
authors.initials: H
authors.lastname: Zhao
mesh_terms: D019143:Evolution, Molecular; D006801:Humans; D035683:MicroRNAs / Q000145:classification / Q000235:genetics*; D010802:Phylogeny
chemical_list: D035683:MicroRNAs
keywords: Evolution; Gene duplication; Mir-181; miRNA