title: Toward continuous LC-MS analysis: surface modification of magnetic microparticles with TiO2 for phosphate adsorption.
abstract: Continuous liquid chromatography-mass spectrometry (LC-MS) analysis was successfully demonstrated by using magnetic TiO2/Fe3O4 microparticles at the desalination interface. The particles could be prepared easily even on a practical scale at sufficient quality for efficient phosphate adsorption. Not only phosphate but several biomolecules were adsorbed onto the particles in a non-specific manner. Such samples could still be detected effectively in MS because the removal of phosphate derived from the LC eluent enhanced sample ionization and resulted in a significant reduction of phosphate cluster ions.
authors.affiliation: a Department of Applied Biological Science , Tokyo University of Agriculture and Technology , Tokyo , Japan.
authors.forename: Issei
authors.initials: I
authors.lastname: Akutagawa
authors.forename: Yoshitake
authors.initials: Y
authors.lastname: Akiyama
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Motoyuki
authors.initials: M
authors.lastname: Iijima
authors.forename: Yohei
authors.initials: Y
authors.lastname: Okada
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Kamiya
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Chiba
mesh_terms: D000327:Adsorption; D002853:Chromatography, Liquid / Q000379:methods*; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D013058:Mass Spectrometry / Q000379:methods*; D008863:Microspheres; D010710:Phosphates / Q000737:chemistry*; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*
chemical_list: D010710:Phosphates; C009495:titanium dioxide; D014025:Titanium; D052203:Ferrosoferric Oxide
keywords: continuous LC–MS analysis; desalination interface; magnetic TiO2/Fe3O4 microparticles; phosphate adsorption