title: MicroRNA-mediated repression combats depression.
abstract: Precisely how SSRIs induce long-term modifications in serotonin transmission to elicit their antidepressant actions is unclear. In this issue of Neuron, Issler et al. (2014) identify a key role for microRNA-135a [corrected] in the raphe nuclei in the molecular mechanisms underlying the therapeutic actions of SSRIs.
authors.affiliation: Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029-6574, USA.
authors.forename: Mary P
authors.initials: MP
authors.lastname: Heyer
authors.affiliation: Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029-6574, USA. Electronic address: paul.kenny@mssm.edu.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Kenny
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects*; D003863:Depression / Q000188:drug therapy*; D035683:MicroRNAs / Q000235:genetics*; D055500:Resilience, Psychological; D012701:Serotonin / Q000378:metabolism*; D013315:Stress, Psychological / Q000235:genetics*
chemical_list: D000928:Antidepressive Agents; D035683:MicroRNAs; C549289:Mirn135 microRNA, mouse; D012701:Serotonin