title: Poisson-like spiking in circuits with probabilistic synapses.
abstract: Neuronal activity in cortex is variable both spontaneously and during stimulation, and it has the remarkable property that it is Poisson-like over broad ranges of firing rates covering from virtually zero to hundreds of spikes per second. The mechanisms underlying cortical-like spiking variability over such a broad continuum of rates are currently unknown. We show that neuronal networks endowed with probabilistic synaptic transmission, a well-documented source of variability in cortex, robustly generate Poisson-like variability over several orders of magnitude in their firing rate without fine-tuning of the network parameters. Other sources of variability, such as random synaptic delays or spike generation jittering, do not lead to Poisson-like variability at high rates because they cannot be sufficiently amplified by recurrent neuronal networks. We also show that probabilistic synapses predict Fano factor constancy of synaptic conductances. Our results suggest that synaptic noise is a robust and sufficient mechanism for the type of variability found in cortex.
authors.affiliation: Research Unit, Parc Sanitari Sant Joan de Déu and Universitat de Barcelona, Esplugues de Llobregat, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Esplugues de Llobregat, Barcelona, Spain.
authors.forename: Rubén
authors.initials: R
authors.lastname: Moreno-Bote
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D002540:Cerebral Cortex / Q000502:physiology; D004553:Electric Conductivity; D008564:Membrane Potentials; D008959:Models, Neurological; D015233:Models, Statistical; D009474:Neurons / Q000502:physiology; D016012:Poisson Distribution; D013569:Synapses / Q000502:physiology*