title: Comparison of 12- and 16-core prostate biopsy in japanese patients with serum prostate-specific antigen level of 4.0-20.0 ng/mL.
abstract: OBJECTIVE
  In the present study, we compared 12- with 16-core biopsy in patients with prostate- specific antigen (PSA) levels of 4.0-20.0 ng/mL.
  
  
  METHODS
  Between 2003 and 2010, 332 patients whose serum PSA level was between 4.0 and 20.0 ng/mL underwent initial transrectal ultrasound (TRUS)-guided needle biopsy. Of those patients, 195 underwent 12-core biopsy and 137 underwent 16-core biopsy.
  
  
  RESULTS
  In the 12-core prostate biopsy group, 66 (33.8%) patients were found to have prostate cancer. On the other hand, in the 16-core prostate biopsy group of 137 patients, 61 (44.5%) were found to have prostate cancer. Among all patients, the prostate cancer detection rate was slightly higher in the 16-core biopsy group than in the 12-core biopsy group. Moreover, in patients with prostate volume > 30 mL or PSA density (PSAD) < 0.2, the prostate cancer detection rate was significantly higher in the 16-core biopsy group than in the 12-core biopsy group. There was no significant difference in pathological tumor grade, indolent cancer probability, or biopsy complication rate between the two groups.
  
  
  CONCLUSIONS
  In order to detect prostate cancer, 16-core prostate biopsy is safe and feasible for Japanese patients with serum PSA level of 4.0-20.0 ng/mL.
authors.affiliation: Department of Urology, Yokohama City Medical Center, Yokohama, Japan. miyoyasu@med.yokohamacu. ac.jp.
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Miyoshi
authors.affiliation: Department of Urology, Yokohama City Medical Center, Yokohama, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Furuya
authors.affiliation: Department of Urology, Yokohama City Medical Center, Yokohama, Japan.
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Teranishi
authors.affiliation: Department of Urology, Yokohama City Medical Center, Yokohama, Japan.
authors.forename: Kazumi
authors.initials: K
authors.lastname: Noguchi
authors.affiliation: Department of Urology, Yokohama City Medical Center, Yokohama, Japan.
authors.forename: Hiroji
authors.initials: H
authors.lastname: Uemura
authors.affiliation: Department of Urology, Yokohama City Medical Center, Yokohama, Japan.
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Yokomizo
authors.affiliation: Department of Urology, Yokohama City Medical Center, Yokohama, Japan.
authors.forename: Shinpei
authors.initials: S
authors.lastname: Sugiura
authors.affiliation: Department of Urology, Yokohama City Medical Center, Yokohama, Japan.
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Kubota
mesh_terms: D000368:Aged; D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood* / Q000473:pathology*
chemical_list: D017430:Prostate-Specific Antigen