title: Assessment of ischemia-modified albumin levels in patients with rheumatoid arthritis.
abstract: BACKGROUND
  Oxygen metabolism has an important role in the pathogenesis of rheumatoid arthritis (RA). Abundant amounts of ROS have been identified in the synovial fluid of RA patients. The accumulation of ROS in cells also serves as an important intracellular signaling of molecules that amplify the synovial inflammatory-proliferative response. Thus, the aim of this study was to assess the IMA levels and other oxidative stress and inflammatory biomarkers in RA subjects.
  
  
  METHODS
  IMA, AOPP, CRP, hemoglobin, Hct, MCV, RF, creatinine, urea levels were assessed in 16 RA subjects and 20 healthy controls.
  
  
  RESULTS
  IMA levels were significantly higher in the RA group than in the control group (0.495 +/- 0.01 vs. 0.433 +/- 0.02 ABSU, p = 0.038). No significant differences were observed for the other markers studied.
  
  
  CONCLUSIONS
  This study demonstrated that RA is related to oxidative stress and inflammation. We also showed for the first time an increase of IMA levels in RA subjects, suggesting that this pathology promotes an increase in the oxidative stress process.
authors.forename: Michele R
authors.initials: MR
authors.lastname: Leitemperguer
authors.forename: Etiane
authors.initials: E
authors.lastname: Tatsch
authors.forename: Helena
authors.initials: H
authors.lastname: Kober
authors.forename: José Antônio M
authors.initials: JA
authors.lastname: De Carvalho
authors.forename: Rafael N
authors.initials: RN
authors.lastname: Moresco
authors.forename: José Edson P
authors.initials: JE
authors.lastname: Da Silva
mesh_terms: D001172:Arthritis, Rheumatoid / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000097:blood; D012709:Serum Albumin; D000075462:Serum Albumin, Human; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers; D017382:Reactive Oxygen Species; D012709:Serum Albumin; C561522:ischemia-modified albumin; D002097:C-Reactive Protein; D000075462:Serum Albumin, Human