title: Dietary enrichment with alpha-linolenic acid during pregnancy attenuates insulin resistance in adult offspring in mice.
abstract: OBJECTIVE
  Our objective was to test the contribution of dietary enrichment in essential or saturated fatty acids, in normocaloric diets, on the lipid accumulation and insulin resistance in the adult offspring in a C57Bl6/J mice model.
  
  
  METHODS
  Pregnant mothers were fed normocaloric diets containing 6% fat enriched in essential fatty acids (EFA): alpha-linolenic (ALA-18:3, n-3), linoleic (LA-18:2, n-6), or saturated fatty acids (SFA). After a washing-out period with regular diet, the offspring received a high-fat diet before euthanization.
  
  
  RESULTS
  Adult mice fed maternal ALA showed lower body weight gain and lower liver fat accumulation, lower HOMA index and lower stearoyl-CoA desaturase (SCD1) activity than those fed maternal SFA.
  
  
  CONCLUSIONS
  The results observed using this novel model suggest that ALA in maternal diet may have the potential to inhibit insulin resistance in adult offspring.
authors.affiliation: Minerva Center for Cholesterol, Gallstones Research and Lipid Metabolism in the Liver .
authors.forename: K S
authors.initials: KS
authors.lastname: Hollander
authors.forename: C
authors.initials: C
authors.lastname: Tempel Brami
authors.forename: F M
authors.initials: FM
authors.lastname: Konikoff
authors.forename: M
authors.initials: M
authors.lastname: Fainaru
authors.forename: A
authors.initials: A
authors.lastname: Leikin-Frenkel
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects; D050154:Adiposity / Q000187:drug effects; D000375:Aging / Q000097:blood / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D019587:Dietary Supplements / Q000032:analysis*; D005227:Fatty Acids / Q000494:pharmacology; D005260:Female; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009035:Mothers; D011247:Pregnancy; D017962:alpha-Linolenic Acid / Q000008:administration & dosage / Q000032:analysis / Q000097:blood / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D005227:Fatty Acids; D007328:Insulin; D017962:alpha-Linolenic Acid
keywords: alpha-linolenic acid; dietary enrichment; insulin resistance; pregnancy