title: [Clinical evaluation of the effectiveness of radiation treatment for cervical cancer].
abstract: The study is based on data on 1756 patients with cervical cancer treated as combined (remote + contact) and only the contact exposure with low, medium and high dose rate. For comparative radiobiological evaluation of reactions of irradiated tissues there were used the following radiobiological models: factor time-dose-fractionation, the cumulative radiation effect, linear- quadratic model in the variant of biologically effective dose. Survival of cervical cancer patients undergone combined radiation treatment was determined by the stage of disease. In particular, the survival of patients with Stage IB cervical cancer was significantly higher than in Stages IIB and IIIB, while in Stage IIB was significantly higher than in Stage IIIB. Long-term results of radiation treatment of patients with Stage IB1 (T1b1N0M0) and Stage IIB (T2bN0M0) cervical cancer did not depend on whether the contact radiation exposure was combined or single. The most preferred component of radiotherapy in women suffering from cervical cancer was brachytherapy with high dose rate.
authors.forename: V G
authors.initials: VG
authors.lastname: Turkevich
mesh_terms: D000328:Adult; D000368:Aged; D001918:Brachytherapy; D019583:Dose Fractionation, Radiation; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D011878:Radiotherapy / Q000379:methods; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D012426:Russia / Q000453:epidemiology; D016019:Survival Analysis; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*