title: An H₂O₂-responsive nanocarrier for dual-release of platinum anticancer drugs and O₂: controlled release and enhanced cytotoxicity against cisplatin resistant cancer cells.
abstract: Synergistic release of platinum anticancer drugs and O2 can be achieved in an H2O2-responsive nanocarrier incorporated with catalase. Such a system combines the advantages of chemotherapy and oxygen therapy and demonstrated improved therapeutic efficacy against cisplatin resistant cell lines which often appear to be in hypoxia.
authors.affiliation: State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China. heweij69@nju.edu.cn zguo@nju.edu.cn.
authors.forename: Huachao
authors.initials: H
authors.lastname: Chen
authors.forename: Weijiang
authors.initials: W
authors.lastname: He
authors.forename: Zijian
authors.initials: Z
authors.lastname: Guo
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D002374:Catalase / Q000008:administration & dosage / Q000378:metabolism; D015687:Cell Hypoxia / Q000187:drug effects; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000494:pharmacology; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000378:metabolism*; D019008:Drug Resistance, Neoplasm; D006367:HeLa Cells; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism*; D019344:Lactic Acid / Q000737:chemistry / Q000378:metabolism; D053758:Nanoparticles / Q000737:chemistry / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy; D009944:Organoplatinum Compounds / Q000008:administration & dosage* / Q000494:pharmacology; D010100:Oxygen / Q000008:administration & dosage* / Q000494:pharmacology; D011100:Polyglycolic Acid / Q000737:chemistry / Q000378:metabolism; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer
chemical_list: D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D009944:Organoplatinum Compounds; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D006861:Hydrogen Peroxide; D002374:Catalase; D002945:Cisplatin; D010100:Oxygen