title: New derivatives of nonactic and homononactic acids from Bacillus pumilus derived from Breynia fruticosa.
abstract: Six new nonactic and homononactic acid derivatives, ethyl homononactate (1), ethyl nonactate (2), homononactyl homononactate (6), ethyl homononactyl nonactate (7), ethyl homononactyl homononactate (8), and ethyl nonactyl nonactate (9), as well as four known compounds, homononactic acid (3), nonactic acid (4), homononactyl nonactate (5), and bishomononactic acid (10), were isolated from culture broth of Bacillus pumilus derived from Breynia fruticosa. The structures of new compounds were elucidated by spectroscopic analysis and chemical methods. The optical purities of 1-6 were determined by HPLC/MS after treatment with L-phenylalanine methyl ester. The dimeric compounds 5-9 showed weak cytotoxic activities against five human cancer cell lines (IC50 19-100 μg/ml).
authors.affiliation: Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang 110819, P. R. China (phone/fax: +86-24-24245710).
authors.forename: Li
authors.initials: L
authors.lastname: Han
authors.forename: Peiyuan
authors.initials: P
authors.lastname: Huo
authors.forename: Huahong
authors.initials: H
authors.lastname: Chen
authors.forename: Songtao
authors.initials: S
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Jiang
authors.forename: Liya
authors.initials: L
authors.lastname: Li
authors.forename: Lihua
authors.initials: L
authors.lastname: Xu
authors.forename: Chenglin
authors.initials: C
authors.lastname: Jiang
authors.forename: Xueshi
authors.initials: X
authors.lastname: Huang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001407:Bacillus / Q000737:chemistry* / Q000502:physiology; D045744:Cell Line, Tumor; D019665:Euphorbiaceae / Q000382:microbiology*; D005663:Furans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D011422:Propionates / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D005663:Furans; D011422:Propionates
keywords: Bacillus pumilus; Breynia fruticosa; Cytotoxic activity; Homononactic acid derivatives; Nonactic acid derivatives