title: Anti-Müllerian hormone concentration as a biomarker of pregnancy success or failure.
abstract: OBJECTIVE
  This study was conducted to determine serum anti-Müllerian hormone (AMH) concentration influence on pregnancy outcome.
  
  
  METHODS
  In this study we investigated sixty one infertile women (aged 27 to 44 years) who were diagnosed and treated between 2011 and 2013. We determine ovarian reserve measured by AMH concentration. Patients were divided in three groups according to their serum AMH concentration (<1 ng/ml; 1-2.5 ng/ml; >2.5 ng/ml respectively). We investigated the relationship between clinical pregnancy rate and AMH concentration. In addition, anti-thyroid antibodies (anti-TG and/or anti-TPO) positivity and insulin concentration were correlated with AMH level and pregnancy outcome in the study groups.
  
  
  RESULTS
  We found no statistical differences between AMH concentration regarding number of pregnancies (42.3%; 41.1 %; 38.9% respectively in study groups; p>0.05). The miscarriage rate was highest in women with AMH>2.5 ng/mL (27.3%, 0%, 86% respectively in study groups; p>0.05). We found that anti-thyroid positivity is more frequent in women with lower AMH concentration (23.1%; 11.7%; 5.5% respectively; p>0.05) and patients with lower serum AMH had higher serum insulin concentration (p<0.05).
  
  
  CONCLUSIONS
  It seems that AMH concentration might not reflect oocyte quality and the chance of pregnancy, but increased AMH concentration may be associated with negative pregnancy outcome. Moreover, it cannot be excluded that presence of anti-thyroid antibodies and increased insulin serum concentration may be connected to diminished ovarian reserve measured by AMH concentration.
authors.affiliation: Department of Gynecology and Oncological Gynecology, Military Institute of Medicine, Warsaw, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Szafarowska
authors.affiliation: Department of Computer Science and Statistics, University of Medical Sciences in Poznan, Poznan, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Molinska-Glura
authors.affiliation: Department of Gynecology and Oncological Gynecology, Military Institute of Medicine, Warsaw, Poland.
authors.forename: Malgorzata M
authors.initials: MM
authors.lastname: Jerzak
mesh_terms: D000022:Abortion, Spontaneous / Q000097:blood* / Q000145:classification; D000328:Adult; D000367:Age Factors; D054304:Anti-Mullerian Hormone / Q000097:blood*; D000906:Antibodies / Q000097:blood; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000097:blood* / Q000145:classification; D007328:Insulin / Q000097:blood; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D013963:Thyroid Hormones / Q000276:immunology
chemical_list: D000906:Antibodies; D015415:Biomarkers; D007328:Insulin; D013963:Thyroid Hormones; D054304:Anti-Mullerian Hormone