title: Rapidly growing non-tuberculous mycobacterial infection in a renal transplant patient after alemtuzumab induction.
abstract: Renal transplant recipients are at high risk of developing opportunistic infections particularly in the first 6 months after transplantation. Organisms causing such infections include rapidly growing non-tuberculous mycobacteria (NTM). Lymphocytes have a central role in combating mycobacterial infections. The use of lymphocyte-depleting agents, such as alemtuzumab, in the renal transplant population has increased in recent years. A case of multifocal osteomyelitis caused by one of the NTM, Mycobacterium chelonae, in a renal transplant recipient, after alemtuzumab induction, is presented.
authors.affiliation: Department of Renal Medicine, Hull and East Yorkshire Hospitals NHS Trust, Hull, UK.
authors.forename: A M
authors.initials: AM
authors.lastname: Hazara
authors.forename: M
authors.initials: M
authors.lastname: Edey
authors.forename: A
authors.initials: A
authors.lastname: Roy
authors.forename: S
authors.initials: S
authors.lastname: Bhandari
mesh_terms: D000074323:Alemtuzumab; D061067:Antibodies, Monoclonal, Humanized / Q000009:adverse effects*; D000995:Antitubercular Agents / Q000627:therapeutic use; D001850:Bone Diseases, Infectious / Q000000981:diagnostic imaging* / Q000382:microbiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009165:Mycobacterium Infections, Nontuberculous / Q000139:chemically induced* / Q000188:drug therapy / Q000382:microbiology; D016926:Mycobacterium chelonae; D009894:Opportunistic Infections / Q000139:chemically induced* / Q000382:microbiology; D011859:Radiography
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000995:Antitubercular Agents; D007166:Immunosuppressive Agents; D000074323:Alemtuzumab
keywords: Mycobacterium chelonae; alemtuzumab; atypical mycobacteria; non-tuberculous mycobacteria