title: Losartan Inhibits Nuclear Factor-κB Activation Induced by Small, Dense LDL Cholesterol Particles in Human Umbilical Vein Endothelial Cells.
abstract: OBJECTIVE
  We aimed to investigate how losartan exerts protective effects on human umbilical vein endothelial cell injury induced by small, dense, LDL (sLDL) cholesterol particles.
  
  
  METHODS
  sLDL cholesterol was isolated by a 2-steps method and the nuclear translocation and activation of nuclear factor-κB (NF-κB) in endothelial cells was observed by confocal microscopy and electrophoretic mobility shift assays.
  
  
  RESULTS
  Losartan greatly inhibited the nuclear translocation of NF-κB induced by sLDL cholesterol in a dose-dependent manner.
  
  
  CONCLUSIONS
  sLDL cholesterol may be involved in endothelial dysfunction possibly through NF-κB activation; losartan protects against sLDL cholesterol-inducing endothelial cell injury by inhibiting NF-κB activation, suggesting that losartan may play a role in the prevention and treatment of cardiovascular disease.
authors.affiliation: Department of Cardiology, The People's Hospital of Rizhao, Rizhao, China.
authors.forename: Gonghui
authors.initials: G
authors.lastname: Guo
authors.affiliation: Department of Cardiology, The People's Hospital of Rizhao, Rizhao, China.
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Cheng
authors.affiliation: Department of Cardiology, The People's Hospital of Rizhao, Rizhao, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Fu
keywords: losartan; nuclear factor-κB; small, dense, LDL