title: Regulatory T cells: exosomes deliver tolerance.
abstract: T regulatory (Treg) cells enforce peripheral tolerance through regulation of diverse immune responses in a context-specific manner. Okoye et al. show one way that Treg cells suppress Th1 cell responses is through nonautonomous gene silencing mediated by microRNA-containing exosomes.
authors.affiliation: Division of Immunology, the Children's Hospital, and the Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. Electronic address: talal.chatila@childrens.harvard.edu.
authors.forename: Talal A
authors.initials: TA
authors.lastname: Chatila
authors.affiliation: Section of Rheumatology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
authors.forename: Calvin B
authors.initials: CB
authors.lastname: Williams
mesh_terms: D055354:Exosomes / Q000235:genetics / Q000276:immunology*; D020868:Gene Silencing / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance / Q000235:genetics* / Q000276:immunology; D035683:MicroRNAs / Q000235:genetics*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D035683:MicroRNAs