title: Recent Research in Antihypertensive Activity of Food Protein-derived Hydrolyzates and Peptides.
abstract: Year to year obesity prevalence, reduced physical activities, bad habits/or stressful lifestyle, and other environmental and physiological impacts lead to increase in diseases such as coronary heart disease, stroke, cancer, diabetes, and hypertension worldwide. Hypertension is considered as one of the most common serious chronic diseases; however, discovery of medications with high efficacy and without side effects for treatment of patients remains a challenge for scientists. Recent trends in functional foods have evidenced that food bioactive proteins play a major role in the concepts of illness and curing; therefore, nutritionists, biomedical scientists, and food scientists are working together to develop improved systems for the discovery of peptides with increased potency and therapeutic benefits. This review presents a recent research carried out to date for the purpose of isolation and identification of bioactive hydrolyzates and peptides with angiotensin I converting enzyme inhibitory activity and antihypertensive effect from animal, marine, microbial, and plant food proteins. Effects of food processing and hydrolyzation conditions as well as some other impacts on formation, activity, and stability of these hydrolyzates and peptides are also presented.
authors.affiliation: a College of Food Science and Nutritional Engineering, China Agricultural University , Beijing , China.|b Department of Food Science and Technology , Faculty of Agriculture, Assiut University , Assiut , Egypt.
authors.forename: Ahmed S M
authors.initials: AS
authors.lastname: Saleh
authors.affiliation: a College of Food Science and Nutritional Engineering, China Agricultural University , Beijing , China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: a College of Food Science and Nutritional Engineering, China Agricultural University , Beijing , China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Shen
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004044:Dietary Proteins / Q000302:isolation & purification / Q000494:pharmacology*; D004195:Disease Models, Animal; D004527:Egg Proteins / Q000302:isolation & purification / Q000494:pharmacology; D005399:Fishes; D005504:Food Analysis; D005511:Food Handling; D005638:Fruit / Q000737:chemistry; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008460:Meat / Q000032:analysis; D008892:Milk / Q000737:chemistry; D008894:Milk Proteins / Q000302:isolation & purification / Q000494:pharmacology; D010940:Plant Proteins / Q000302:isolation & purification / Q000494:pharmacology; D011492:Protein Hydrolysates / Q000302:isolation & purification / Q000494:pharmacology*; D017747:Seafood / Q000032:analysis; D014675:Vegetables / Q000737:chemistry
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D004044:Dietary Proteins; D004527:Egg Proteins; D008894:Milk Proteins; D010940:Plant Proteins; D011492:Protein Hydrolysates
keywords: Angiotensin-converting enzyme (ACE); antihypertensive activity; food peptides; hypertension