title: Virus meets host microRNA: the destroyer, the booster, the hijacker.
abstract: Virus-host interactions highlight key regulatory steps in the control of gene expression. MicroRNAs (miRNAs) are small noncoding RNAs that regulate protein production via base pairing with mRNAs. Both DNA and RNA viruses have evolved mechanisms to degrade, boost, or hijack cellular miRNAs to benefit the viral life cycle. This minireview focuses on recent discoveries in virus-host miRNA interactions.
authors.affiliation: Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut, USA Howard Hughes Medical Institute Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: Yang Eric
authors.initials: YE
authors.lastname: Guo
authors.affiliation: Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut, USA Howard Hughes Medical Institute Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA joan.steitz@yale.edu.
authors.forename: Joan A
authors.initials: JA
authors.lastname: Steitz
mesh_terms: D000818:Animals; D001483:Base Sequence; D004663:Encephalitis Virus, Eastern Equine / Q000502:physiology; D015967:Gene Expression Regulation, Viral; D006564:Herpesviridae / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D011212:Poxviridae / Q000502:physiology*; D034622:RNA Interference; D020871:RNA Stability
chemical_list: D035683:MicroRNAs