title: Homo- and hetero-oligomerization of β2-adrenergic receptor in receptor trafficking, signaling pathways and receptor pharmacology.
abstract: The β2-adrenergic receptor (β2AR) is the prototypic member of G protein-coupled receptors (GPCRs) involved in the production of physiological responses to adrenaline and noradrenaline. Research done in the past few years vastly demonstrated that β2AR can form homo- and hetero-oligomers. Despite the fact that currently this phenomenon is widely accepted, the spread and relevance of β2AR oligomerization are still a matter of debate. This review considers the progress achieved in the field of β2AR oligomerization with focus on the implications of the receptor-receptor interactions to β2AR trafficking, pharmacology and downstream signal transduction pathways.
authors.affiliation: Laboratory of Medicinal Chemistry and Neuroengineering, Department of Chemistry, Medical University of Lublin, 20-093 Lublin, Poland. Electronic address: artur.wnorowski@gmail.com.
authors.forename: Artur
authors.initials: A
authors.lastname: Wnorowski
authors.affiliation: Laboratory of Medicinal Chemistry and Neuroengineering, Department of Chemistry, Medical University of Lublin, 20-093 Lublin, Poland. Electronic address: krzysztof.jozwiak@umlub.pl.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Jozwiak
mesh_terms: D019281:Dimerization; D006801:Humans; D055503:Protein Multimerization; D021381:Protein Transport; D044140:Receptor, Angiotensin, Type 1 / Q000378:metabolism; D018343:Receptors, Adrenergic, beta-2 / Q000737:chemistry / Q000378:metabolism*; D043882:Receptors, Cannabinoid / Q000378:metabolism; D011957:Receptors, Opioid / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D044140:Receptor, Angiotensin, Type 1; D018343:Receptors, Adrenergic, beta-2; D043882:Receptors, Cannabinoid; D011957:Receptors, Opioid
keywords: Beta-adrenoceptor; Oligomerization interface; Receptor mosaic; Receptorosome; Receptor–receptor interaction