title: Effects of ingesting milk fermented by Lactococcus lactis H61 on skin health in young women: a randomized double-blind study.
abstract: We conducted a randomized double-blind trial to evaluate the effects of fermented milk produced using only Lactococcus lactis strain H61 as a starter bacterium (H61-fermented milk) on the general health and various skin properties of young women. Healthy female volunteers (n=23; age=19-21r) received H61-fermented milk (10(10) cfu of strain H61/d) or conventional yogurt (10(10) cfu of both Lactobacillus delbrueckii ssp. bulgaricus and Streptococcus thermophilus per day), as a reference food, daily for 4 wk. Before and at the end of 4 wk, blood samples were taken, and skin hydration (inner forearms and cheek) and melanin content, elasticity, and sebum content (cheek only) were measured. Skin hydration at the inner forearm was higher at wk 4 than at wk 0 in both groups. Sebum content in cheek rose significantly after intervention in the H61-fermented milk group, but not the conventional yogurt group. Other skin parameters did not differ in either group. Serum analysis showed that total protein concentration and platelet count were elevated and reactive oxygen species decreased in both groups after the intervention. Although H61-fermented milk and conventional yogurt had similar effects on skin status and some blood characteristics of participants, an increase of sebum content in cheek is preferable to H61-fermented milk. As skin lipids contribute to maintaining the skin barrier, H61-fermented milk would provide beneficial effects on skin for young women.
authors.affiliation: NARO Institute of Livestock and Grassland Science, Ikenodai 2, Tsukuba, Ibaraki 305-0901, Japan. Electronic address: anne@affrc.go.jp.
authors.forename: H
authors.initials: H
authors.lastname: Kimoto-Nira
authors.affiliation: Juntendo University, Hiragagakuendai 1-1, Inzai, Chiba 270-1695, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nagakura
authors.affiliation: Juntendo University, Hiragagakuendai 1-1, Inzai, Chiba 270-1695, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Kodama
authors.affiliation: Toin University of Yokohama, Tetsumachi 1614, Yokohama, Kanagawa 225-8502, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Shimizu
authors.affiliation: Daito Bunka University, Iwadono 560, Higashimatsuyama, Saitama 355-8501, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Okuta
authors.affiliation: NARO Institute of Livestock and Grassland Science, Ikenodai 2, Tsukuba, Ibaraki 305-0901, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Sasaki
authors.affiliation: Juntendo University, Hiragagakuendai 1-1, Inzai, Chiba 270-1695, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Koikawa
authors.affiliation: Juntendo University, Hiragagakuendai 1-1, Inzai, Chiba 270-1695, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Sakuraba
authors.affiliation: NARO Institute of Livestock and Grassland Science, Ikenodai 2, Tsukuba, Ibaraki 305-0901, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Suzuki
authors.affiliation: Juntendo University, Hiragagakuendai 1-1, Inzai, Chiba 270-1695, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000378:metabolism; D001798:Blood Proteins / Q000032:analysis; D004311:Double-Blind Method; D004548:Elasticity; D005260:Female; D005285:Fermentation; D006801:Humans; D007564:Japan; D013294:Lactococcus lactis / Q000378:metabolism*; D008055:Lipids / Q000097:blood; D008543:Melanins / Q000032:analysis; D008892:Milk / Q000378:metabolism* / Q000382:microbiology; D012629:Sebum / Q000378:metabolism; D012879:Skin Physiological Phenomena / Q000187:drug effects*; D015014:Yogurt / Q000382:microbiology; D055815:Young Adult
chemical_list: D001798:Blood Proteins; D008055:Lipids; D008543:Melanins
keywords: fermented milk; human study; skin health