title: Marker-based estimation of genetic parameters in genomics.
abstract: Linear mixed model (LMM) analysis has been recently used extensively for estimating additive genetic variances and narrow-sense heritability in many genomic studies. While the LMM analysis is computationally less intensive than the Bayesian algorithms, it remains infeasible for large-scale genomic data sets. In this paper, we advocate the use of a statistical procedure known as symmetric differences squared (SDS) as it may serve as a viable alternative when the LMM methods have difficulty or fail to work with large datasets. The SDS procedure is a general and computationally simple method based only on the least squares regression analysis. We carry out computer simulations and empirical analyses to compare the SDS procedure with two commonly used LMM-based procedures. Our results show that the SDS method is not as good as the LMM methods for small data sets, but it becomes progressively better and can match well with the precision of estimation by the LMM methods for data sets with large sample sizes. Its major advantage is that with larger and larger samples, it continues to work with the increasing precision of estimation while the commonly used LMM methods are no longer able to work under our current typical computing capacity. Thus, these results suggest that the SDS method can serve as a viable alternative particularly when analyzing 'big' genomic data sets.
authors.affiliation: Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Zhiqiu
authors.initials: Z
authors.lastname: Hu
authors.affiliation: Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada; Alberta Agriculture and Rural Development, Edmonton, Alberta, Canada.
authors.forename: Rong-Cai
authors.initials: RC
authors.lastname: Yang
mesh_terms: D000818:Animals; D004331:Drosophila melanogaster / Q000235:genetics; D005819:Genetic Markers; D055106:Genome-Wide Association Study / Q000379:methods*; D023281:Genomics; D008957:Models, Genetic; D012984:Software; D014908:Triticum / Q000235:genetics
chemical_list: D005819:Genetic Markers