title: NTPDase5/PCPH as a new target in highly aggressive tumors: a systematic review.
abstract: The protooncogene PCPH was recently identified as being the ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5). This protooncogene is converted into an oncogene by a single base pair deletion, resulting in frame change and producing a premature stop codon, leading to a mutated protein (mt-PCPH) with only 27 kDa, which is much smaller than the original 47 kDa protein. Overexpression of the PCPH as well as the mutated PCPH increases the cellular resistance to stress and apoptosis. This is intriguing considering that the active form, that is, the oncogene, is the mutated PCPH. Several studies analyzed the expression of NTPDase5/mt-PCPH in a wide range of tumor cells and evaluated its role and mechanisms in cancer and other pathogenic processes. The main point of this review is to integrate the findings and proposed theories about the role played by NTPDase5/mt-PCPH in cancer progression, considering that these proteins have been suggested as potential early diagnostic tools and therapy targets.
authors.affiliation: Laboratório de Biologia Celular, Departamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Rua Sarmento Leite, Rua Sarmento Leite, No. 245, 90050-170 Porto Alegre, RS, Brazil.
authors.forename: Paula Andreghetto
authors.initials: PA
authors.lastname: Bracco
authors.affiliation: Laboratório de Biologia Celular, Departamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Rua Sarmento Leite, Rua Sarmento Leite, No. 245, 90050-170 Porto Alegre, RS, Brazil.
authors.forename: Ana Paula Santin
authors.initials: AP
authors.lastname: Bertoni
authors.affiliation: Laboratório de Biologia Celular, Departamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Rua Sarmento Leite, Rua Sarmento Leite, No. 245, 90050-170 Porto Alegre, RS, Brazil.
authors.forename: Márcia Rosângela
authors.initials: MR
authors.lastname: Wink
mesh_terms: D017209:Apoptosis; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D058990:Molecular Targeted Therapy; D009367:Neoplasm Staging; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D015513:Oncogene Proteins / Q000096:biosynthesis / Q000235:genetics*; D011755:Pyrophosphatases / Q000096:biosynthesis / Q000235:genetics*; D017384:Sequence Deletion
chemical_list: D015513:Oncogene Proteins; C117634:ENTPD5 protein, human; D011755:Pyrophosphatases