title: Formulation and evaluation of sustained release matrix tablet of rabeprazole using wet granulation technique.
abstract: BACKGROUND
  Rabeprazole, a member of substituted benzimidazoles, inhibits the final step in gastric acid secretions. This drug claims to cause fastest acid separation (due to higher pKa), and more rapidly converts to the active species to aid gastric mucin synthesis. The most significant pharmacological action of Rabeprazole is dose dependent suppression of gastric acid secretion; without anticholinergic or H2-blocking action. It completely abolishes the hydrochloric acid secretion as it is powerful inhibitor of gastric acid. Rabeprazole is acid labile and hence commonly formulated as an enteric coated tablet. The absorption of rabeprazole occurs rapidly as soon as tablet leaves the stomach.
  
  
  OBJECTIVE
  In the present study an attempt was made to formulate and evaluate Rabeprazole sustained release matrix tablet using wet granulation technique incorporating various polymers like HPMC-E15, Carbopol934, and sodium carboxymethyl cellulose (CMC).
  
  
  METHODS
  The Formulated tablets were evaluated for different physicochemical properties like rheological properties, weight variation, thickness, hardness, % friability, in vitro release studies and drug content.
  
  
  RESULTS
  Studies revealed that all the physicochemical parameters comply with the official standards. The in vitro release studies exhibits the release up to 90%, over a prolonged period of time which confirms the extended release profile of formulation, having better bioavailability as well as decreased dosing frequency with reduced doses.
  
  
  CONCLUSIONS
  The sustained release matrix tablets of rabiprazole shown better bioavailability, efficacy and potency, when compared with official standards.
authors.affiliation: Department of Pharmacology, Siddhartha Institute of Pharmacy, Dehradun, Uttarakhand, India.
authors.forename: Ruqaiyah
authors.initials: R
authors.lastname: Khan
authors.affiliation: Ibne Seena Pharmacy College, Azmi Vidya Nagri, Shahabad Dist. Hardoi, UP, India.
authors.forename: Md Shamim
authors.initials: MS
authors.lastname: Ashraf
authors.affiliation: Department of Pharmacology, Siddhartha Institute of Pharmacy, Dehradun, Uttarakhand, India.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Afzal
authors.affiliation: Department of Pharmacology, Siddhartha Institute of Pharmacy, Dehradun, Uttarakhand, India.
authors.forename: Imran
authors.initials: I
authors.lastname: Kazmi
authors.affiliation: Department of Pharmacology, Luqman College of Pharmacy, Gulbarga, Karnataka, India.
authors.forename: Mohammed Asadullah
authors.initials: MA
authors.lastname: Jahangir
authors.affiliation: Department of Pharmacology, Siddhartha Institute of Pharmacy, Dehradun, Uttarakhand, India.
authors.forename: Rajbala
authors.initials: R
authors.lastname: Singh
authors.affiliation: Department of Pharmaceutics, Dehradun Institute of Technology, Dehradun, Uttarakhand, India.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Chandra
authors.affiliation: Department of Pharmacology, Siddhartha Institute of Pharmacy, Dehradun, Uttarakhand, India.
authors.forename: Firoz
authors.initials: F
authors.lastname: Anwar
keywords: Bioavailability; DENA; HPMC-E15; carcinogen; gatifloxacin; hepatocellular carcinoma; histology; matrix; rabeprazole; sustained release