title: Metastin levels in relation with hormonal and metabolic profile in patients with polycystic ovary syndrome.
abstract: OBJECTIVE
  The aim of the present study was to evaluate serum concentrations of metastin in relation with hormonal and metabolic profile in patients with and without polycystic ovary syndrome (PCOS).
  
  
  METHODS
  The study was a clinical study. Eighty-three women with PCOS and 66 body mass index (BMI) matched controls were divided into two groups, based on BMI: overweight and obese (BMI≥25 kg/m(2)) and normal weight. (BMI<25 kg/m(2)) Hirsutism scores, hormonal and metabolic profile as well as metastin levels were evaluated in each subject. Blood samples were collected in the early follicular phase (between day 2 and day 5 of the menstrual cycle) at 9:00 AM, after an overnight fast. Circulating levels of LH, FSH, PRL, TSH, T, fT, DHEAS, 17-OH-P, sex hormone-binding globulin (SHBG), insulin, glucose, lipid profile and metastin were measured.
  
  
  RESULTS
  Metastin levels were significantly higher in the PCOS group compared to controls (2.02 ng/ml versus 1.16 ng/ml, p<0.001). Metastin levels correlated significantly positively with luteinizing hormone (LH), total testosterone (T), dehydroepiandrosteronesulphate (DHEA-SO4) levels, modified Ferriman-Gallwey (mFG) scores and free androgen index (FAI); however, correlated negatively with sex hormone binding globulin (SHBG) levels (p<0.05). When overweight or obese (BMI≥25 kg/m(2)) and normal weight (BMI<25 kg/m(2)) women with PCOS were compared to body mass index (BMI) matched controls, higher metastin levels were also found in PCOS groups (1.94 ng/ml versus 1.18 ng/ml, and 2.06 ng/ml versus 1.08 ng/ml, p<0.05, respectively).
  
  
  CONCLUSIONS
  These findings suggest that metastin levels were higher in women with PCOS as compared to controls regardless of BMI. Furthermore, metastin levels can be used as a specific marker for androgenic profile and this marker might play a role in the pathogenesis of PCOS.
authors.affiliation: Department of Obstetrics and Gynecology, Selcuk University, Faculty of Medicine, Konya, Turkey. Electronic address: setenayarzu@hotmail.com.
authors.forename: S A
authors.initials: SA
authors.lastname: Yilmaz
authors.affiliation: Department of Obstetrics and Gynecology, Selcuk University, Faculty of Medicine, Konya, Turkey.
authors.forename: O S
authors.initials: OS
authors.lastname: Kerimoglu
authors.affiliation: Department of Obstetrics and Gynecology, Selcuk University, Faculty of Medicine, Konya, Turkey.
authors.forename: A T
authors.initials: AT
authors.lastname: Pekin
authors.affiliation: Department of Obstetrics and Gynecology, Selcuk University, Faculty of Medicine, Konya, Turkey.
authors.forename: F
authors.initials: F
authors.lastname: Incesu
authors.affiliation: Department of Obstetrics and Gynecology, Akdeniz University, Faculty of Medicine, Antalya, Turkey.
authors.forename: N U
authors.initials: NU
authors.lastname: Dogan
authors.affiliation: Department of Obstetrics and Gynecology, Selcuk University, Faculty of Medicine, Konya, Turkey.
authors.forename: C
authors.initials: C
authors.lastname: Celik
authors.affiliation: Department of Biochemistry, Selcuk University, Faculty of Medicine, Konya, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Unlu
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose; D016022:Case-Control Studies; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006628:Hirsutism / Q000209:etiology; D006801:Humans; D007333:Insulin Resistance; D059648:Kisspeptins / Q000097:blood*; D008055:Lipids / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D009765:Obesity / Q000097:blood* / Q000150:complications; D050177:Overweight / Q000097:blood / Q000150:complications; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications; D011388:Prolactin / Q000097:blood; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013739:Testosterone / Q000097:blood; D013972:Thyrotropin / Q000097:blood; D055815:Young Adult
chemical_list: D001786:Blood Glucose; C106628:KISS1 protein, human; D059648:Kisspeptins; D008055:Lipids; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D019314:Dehydroepiandrosterone Sulfate; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin
keywords: Insulin resistance; Kisspeptin; Metastin; PCOS