title: Alteration of ischemia modified albumin and nitric oxide levels in hypothyroidism.
abstract: BACKGROUND
  Thyroid disorders especially hypothyroidism is associated with increased generation of oxidants. Nitric oxide and ischemia modified albumin are considered markers for oxidative stress. In addition, nitric oxide is involved in regulation of thyroid function and coagulation profile alteration in thyroid disorders may produce ischemia like conditions.
  
  
  METHODS
  Nitric oxide and ischemia modified albumin were estimated in fifty patients of newly diagnosed hypothyroidism using standard photocolorimetric techniques. Results were compared with fifty healthy euthyroid controls and subjected to appropriate statistical analysis.
  
  
  RESULTS
  Nitric oxide and ischemia modified albumin were found to be significantly raised (p < 0.05) in hypothyroid patients as compared to controls. A positive, but statistically insignificant correlation was observed between nitric oxide and ischemia modified albumin.
  
  
  CONCLUSIONS
  Estmation of nitric oxide and ischemia modified albumin in hypothyroidism may help to throw light on its pathogenesis and assessing the severity of the disease, though further research is needed to establish their role as biomarkers in hypothyroidism.
authors.forename: Kiran
authors.initials: K
authors.lastname: Dahiya
authors.forename: Monica
authors.initials: M
authors.lastname: Verma
authors.forename: Rakesh
authors.initials: R
authors.lastname: Dhankhar
authors.forename: Veena
authors.initials: V
authors.lastname: Singh
authors.forename: Pratap S
authors.initials: PS
authors.lastname: Ghalaut
authors.forename: Shashi
authors.initials: S
authors.lastname: Seth
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*; D018384:Oxidative Stress; D012016:Reference Values; D012709:Serum Albumin; D000075462:Serum Albumin, Human; D018709:Statistics, Nonparametric; D055815:Young Adult
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; C561522:ischemia-modified albumin; D009569:Nitric Oxide; D000075462:Serum Albumin, Human