title: Depletion of penicillin G residues in heavy sows after intramuscular injection. Part II: application of kidney inhibition swab tests.
abstract: Sows (n = 126; 228 ± 30.1 kg) were administered daily IM doses of penicillin G procaine (33 000 IU/kg bw; 5× the label dose) for 3 consecutive days using three different administration patterns. Within treatment, six sows each were slaughtered on withdrawal day 5, 10, 15, 20, 25, 32, and 39. Tissues (injection site, kidney, liver, skeletal muscle) or body fluids (serum and urine) were screened for penicillin G using the KIS test, recently adopted by the USDA Food Safety and Inspection Service. The IM administration patterns had no discernible effect on penicillin G depletion. Residues were depleted more rapidly from liver and skeletal muscle and more slowly from kidney and urine. Kidney was the most sensitive and suitable tissue for detecting penicillin G residues on-site, with two positive results after a 39-day withdrawal period. Urine was the most suitable ante-mortem surrogate to predict the results of kidney tests.
authors.affiliation: Biosciences Research Laboratory, USDA-ARS , Fargo, North Dakota 58102-2765, United States.
authors.forename: Weilin L
authors.initials: WL
authors.lastname: Shelver
authors.forename: Sara J
authors.initials: SJ
authors.lastname: Lupton
authors.forename: David J
authors.initials: DJ
authors.lastname: Newman
authors.forename: Steven
authors.initials: S
authors.lastname: Larsen
authors.forename: David J
authors.initials: DJ
authors.lastname: Smith
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004350:Drug Residues / Q000032:analysis* / Q000493:pharmacokinetics; D005260:Female; D007273:Injections, Intramuscular; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism; D010402:Penicillin G Procaine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012680:Sensitivity and Specificity; D013552:Swine
chemical_list: D010402:Penicillin G Procaine