title: Association between family history of malignant neoplasm with colorectal adenomatous polyp in 40s aged relative person.
abstract: OBJECTIVE
  We assessed the association between a family history of malignancy and risk of colorectal adenoma among individuals aged 40-49 years.
  
  
  METHODS
  The study population consisted of subjects, aged in their 40s, who underwent colonoscopy. Their family histories of cancer were collected with a self-administered questionnaire. A logistic regression model was used to assess the association between a family history of cancer and the risk of colorectal polyp.
  
  
  RESULTS
  In total, 2275 participants were included in the study. Univariate analysis showed that old age, male sex, current cigarette smoking, BMI>25 kg/m(2), and a family history of colorectal cancer (CRC) were risk factors for the development of sporadic colorectal adenomatous polyps in these patients. A multivariate analysis showed that a family history of CRC or kidney cancer was associated with adenoma development. A family history of CRC was also a risk factor for advanced and multiple adenoma.
  
  
  CONCLUSIONS
  This study shows that a family history of CRC is a risk factor for advanced and multiple colorectal adenoma in people in their 40s. These results support earlier screening for colorectal neoplasms in individuals with a family history of CRC.
authors.affiliation: Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang-si, Gyeonggi-do, Republic of Korea.
authors.forename: Su Young
authors.initials: SY
authors.lastname: Lee
authors.affiliation: Molecular Epidemiology Branch, Research Institute, National Cancer Center, Goyang-si, Gyeonggi-do, Republic of Korea.
authors.forename: Aesun
authors.initials: A
authors.lastname: Shin
authors.affiliation: Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang-si, Gyeonggi-do, Republic of Korea. Electronic address: mdzara@ncc.re.kr.
authors.forename: Byung Chang
authors.initials: BC
authors.lastname: Kim
authors.affiliation: Molecular Epidemiology Branch, Research Institute, National Cancer Center, Goyang-si, Gyeonggi-do, Republic of Korea.
authors.forename: Jeong Hee
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang-si, Gyeonggi-do, Republic of Korea.
authors.forename: Kyung Su
authors.initials: KS
authors.lastname: Han
authors.affiliation: Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang-si, Gyeonggi-do, Republic of Korea.
authors.forename: Chang Won
authors.initials: CW
authors.lastname: Hong
authors.affiliation: Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang-si, Gyeonggi-do, Republic of Korea.
authors.forename: Dae Kyung
authors.initials: DK
authors.lastname: Sohn
authors.affiliation: Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang-si, Gyeonggi-do, Republic of Korea.
authors.forename: Sung Chan
authors.initials: SC
authors.lastname: Park
authors.affiliation: Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang-si, Gyeonggi-do, Republic of Korea.
authors.forename: Hee Jin
authors.initials: HJ
authors.lastname: Chang
authors.affiliation: Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang-si, Gyeonggi-do, Republic of Korea.
authors.forename: Jae Hwan
authors.initials: JH
authors.lastname: Oh
mesh_terms: D000236:Adenoma / Q000453:epidemiology*; D018256:Adenomatous Polyps / Q000453:epidemiology*; D000328:Adult; D003113:Colonoscopy / Q000379:methods; D015179:Colorectal Neoplasms / Q000453:epidemiology*; D005192:Family Health; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D012307:Risk Factors; D011795:Surveys and Questionnaires
keywords: 40s aged relative person; Colorectal adenoma; Colorectal cancer; Family history