title: Tumor suppressor TSLC1 inhibits growth, proliferation, invasiveness and angiogenesis in nude mice xenografted tumor of Eca109 cells.
abstract: Tumor suppressor in lung cancer 1 (TSLC1) is a novel tumor suppressor gene whose inactivation is implicated in the occurrence, invasion, metastasis and prognosis of esophageal cancer. TSLC1 was studied by comparing the tumor formation of TSLC1 transfectant and control cells in nude mice. Compared with blank group and mock group, tumor size and infiltrating range of transfected group was less, differentiation of tumor tissue was slightly better, and differences of tumor angiogenesis was worse. There was no obvious difference between blank group and mock group. We have shown TSLC1 gene inhibited the growth proliferation, infiltration and angiogenesis of Eca109 cells.
authors.affiliation: Department of Oncology, Affiliated Hospital of Guangdong Medical College Zhanjiang, 524001, China.
authors.forename: Qi-Lian
authors.initials: QL
authors.lastname: Liang
authors.affiliation: Department of Oncology, Affiliated Hospital of Guangdong Medical College Zhanjiang, 524001, China.
authors.forename: Guo-Qiang
authors.initials: GQ
authors.lastname: Chen
authors.affiliation: Department of Oncology, Affiliated Hospital of Guangdong Medical College Zhanjiang, 524001, China.
authors.forename: Qiu-Long
authors.initials: QL
authors.lastname: Liu
authors.affiliation: Department of Radiotherapy, Cancer Center of Guangzhou Medical University Guangzhou, 510095, China.
authors.forename: Zhou-Yu
authors.initials: ZY
authors.lastname: Li
authors.affiliation: Department of Pathophysiology, School of Basic Medical Science, Guangdong Medical College Dongguan, 523808, China.
authors.forename: Xiang-Ning
authors.initials: XN
authors.lastname: Zhang
authors.affiliation: Department of Oncology, Affiliated Hospital of Guangdong Medical College Zhanjiang, 524001, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Oncology, Affiliated Hospital of Guangdong Medical College Zhanjiang, 524001, China.
authors.forename: Wen-Ting
authors.initials: WT
authors.lastname: Ou
authors.affiliation: Department of Chemotherapy, Cancer Center of Guangzhou Medical University Guangzhou, 510095, China.
authors.forename: Bi-Rong
authors.initials: BR
authors.lastname: Wang
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Guangdong Medical College Zhanjiang, 524023, China.
authors.forename: Li-Ren
authors.initials: LR
authors.lastname: Hu
keywords: Tumor suppressor gene; esophageal cancer; nude mice; tumor suppressor in lung cancer -1 (TSLC1); tumorigenicity