title: Effects of rumen-protected γ-aminobutyric acid on performance and nutrient digestibility in heat-stressed dairy cows.
abstract: This experiment was conducted to investigate the effects of rumen-protected γ-aminobutyric acid (GABA) on performance and nutrient digestibility in heat-stressed dairy cows. Sixty Holstein dairy cows (141±15 d in milk, 35.9±4.3kg of milk/d, and parity 2.0±1.1) were randomly assigned to 1 of 4 treatments according to a completely randomized block design. Treatments consisted of 0 (control), 40, 80, or 120mg of true GABA/kg of dry matter (DM). The trial lasted 10wk. The average temperature-humidity indices at 0700, 1400, and 2200h were 78.4, 80.2, and 78.7, respectively. Rectal temperatures decreased linearly at 0700, 1400, and 2200h with increasing GABA concentration. Supplementation of GABA had no effect on respiration rates at any time point. Dry matter intake, energy-corrected milk, 4% fat-corrected milk, and milk fat yield tended to increase linearly with increasing GABA concentration. Supplementation of GABA affected, in a quadratic manner, milk protein and lactose concentrations, and milk protein yield, and the peak values were reached at a dose of 40mg of GABA/kg. Milk urea nitrogen concentration responded quadratically. Total solids content increased linearly with increasing GABA concentration. Supplementation of GABA had no effect on milk yield, lactose production, total solids, milk fat concentration, somatic cell score, or feed efficiency. Apparent total-tract digestibilities of DM, organic matter, crude protein, neutral detergent fiber, and acid detergent fiber were similar among treatments. These results indicate that rumen-protected GABA supplementation to dairy cows can alleviate heat stress by reducing rectal temperature, increase DM intake and milk production, and improve milk composition. The appropriate supplemental GABA level for heat-stressed dairy cows is 40mg/kg of DM.
authors.affiliation: State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, P. R. China; College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, P. R. China.
authors.forename: J B
authors.initials: JB
authors.lastname: Cheng
authors.affiliation: State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, P. R. China.
authors.forename: D P
authors.initials: DP
authors.lastname: Bu
authors.affiliation: State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, P. R. China. Electronic address: wangjiaqi@caas.cn.
authors.forename: J Q
authors.initials: JQ
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, P. R. China; College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, P. R. China.
authors.forename: X Z
authors.initials: XZ
authors.lastname: Sun
authors.affiliation: State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, P. R. China.
authors.forename: L
authors.initials: L
authors.lastname: Pan
authors.affiliation: State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, P. R. China.
authors.forename: L Y
authors.initials: LY
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, P. R. China.
authors.forename: W
authors.initials: W
authors.lastname: Liu
mesh_terms: D000818:Animals; D001831:Body Temperature; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy / Q000378:metabolism*; D019587:Dietary Supplements; D004063:Digestion / Q000187:drug effects*; D004435:Eating / Q000187:drug effects; D005260:Female; D018882:Heat Stress Disorders / Q000188:drug therapy / Q000378:metabolism / Q000662:veterinary*; D006358:Hot Temperature; D007774:Lactation / Q000187:drug effects; D008892:Milk / Q000737:chemistry / Q000166:cytology; D008894:Milk Proteins / Q000032:analysis; D012417:Rumen / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage*
chemical_list: D008894:Milk Proteins; D005680:gamma-Aminobutyric Acid
keywords: heat stress; milk yield; γ-aminobutyric acid