title: The association between the low muscle mass and osteoporosis in elderly Korean people.
abstract: The purpose of this study was to predict osteoporosis risk as decreasing muscle mass and to declare the cut-off value of low muscle mass in an elderly Korean population. This study was based on data from the 2008-2010 Korea National Health and Nutritional Examination Surveys (KNHANES). The subjects included 1,308 men and 1,171 women over 65 yr. Bone mineral density (BMD) and appendicular skeletal muscle (ASM) were measured by dual energy X-ray absorptiometry (DXA), and appendicular skeletal muscle was adjusted by height as a marker of sarcopenia. After confirming the correlation between low muscle mass and BMD, the best cut-off value of muscle mass to estimate osteoporosis was suggested through the receiver operating characteristic (ROC) curve. For both men and women, BMD correlated positively with low muscle mass when ASM/Ht(2) was used as a marker for sarcopenia. The ROC curve showed that ASM/Ht(2) was the best marker for osteoporosis at a cut-off value of 6.85 kg/m(2) for men and 5.96 kg/m(2) for women. When these cut-off values were used to determine sarcopenia, the risk of osteoporosis increased 4.14 times in men and 1.88 times in women. In particular, men (OR 2.12) with sarcopenia were more greatly affected than women (OR 1.15), even after adjusting for osteoporosis risk factors. In elderly Korean people, sarcopenia is positively correlated with BMD and there is a strong correlation between sarcopenia and osteoporosis with risk of bone fracture.
authors.affiliation: Department of Family Medicine, College of Medicine, Kyung Hee University, Seoul, Korea. ; Department of Medicine, Graduate School Ewha Womans University, Seoul, Korea.
authors.forename: Sunyoung
authors.identifier: 0000-0003-4115-4455
authors.initials: S
authors.lastname: Kim
authors.affiliation: Department of Family Medicine, College of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Chang Won
authors.identifier: 0000-0002-6429-4461
authors.initials: CW
authors.lastname: Won
authors.affiliation: Department of Family Medicine, College of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Byung Sung
authors.identifier: 0000-0002-4984-6918
authors.initials: BS
authors.lastname: Kim
authors.affiliation: Department of Family Medicine, College of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Hyun Rim
authors.identifier: 0000-0003-4356-2831
authors.initials: HR
authors.lastname: Choi
authors.affiliation: Department of Family Medicine, College of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Min Young
authors.identifier: 0000-0002-7207-8155
authors.initials: MY
authors.lastname: Moon
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D044466:Asian People; D015992:Body Mass Index; D015519:Bone Density; D005260:Female; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging / Q000473:pathology*; D009749:Nutrition Surveys; D016017:Odds Ratio; D010024:Osteoporosis / Q000175:diagnosis* / Q000209:etiology; D012372:ROC Curve; D056910:Republic of Korea; D012307:Risk Factors; D055948:Sarcopenia / Q000503:physiopathology
keywords: Elderly Population; KNHANES; Korea; Osteoporosis; Sarcopenia