title: Mesenchymal stromal cells: main factor or helper in regenerative medicine?
abstract: Mesenchymal stromal cells (mSCs) are presently studied for the prophylaxis and therapy of a variety of diseases such as acute graft-versus-host disease after allogeneic stem cell transplantation, cardiac indications, bone degeneration, Crohn's disease, and organ rejection, as well as prevention of acute renal failure in high-risk situations. mSCs appear to function through paracrine mechanisms that exert immunosuppressive, anti-inflammatory, anti-apoptotic, mitogenic, and other organ-protective and repair-stimulating actions. mSCs are either cultured in the presence of fetal calf serum (FCS) or platelet lysate (PL). PL lysate-generated mSCs exhibit faster doubling times, different gene expression profiles, and more potent immunosuppressive activity compared with FSC-generated mSCs. The utility of mSCs in the treatment of chronic inflammatory diseases is being evaluated in prospective studies.
authors.affiliation: University Medical Center, Hamburg-Eppendorf, Clinic for Stem Cell Transplantation , Hamburg, Germany.
authors.forename: Axel R
authors.initials: AR
authors.lastname: Zander
authors.affiliation: University Medical Center, Hamburg-Eppendorf, Clinic for Stem Cell Transplantation , Hamburg, Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: Lange
authors.affiliation: Section of Nephrology, George E. Wahlen VA Medical Center, University of Utah , Salt Lake City, Utah, USA; ; Department of Medicine, University of Utah College of Medicine , Salt Lake City, Utah, USA ; Department of Physiology, University of Utah College of Medicine , Salt Lake City, Utah, USA.
authors.forename: Christof
authors.initials: C
authors.lastname: Westenfelder
keywords: fusion; organ injury; paracrine actions; plasticity