title: Disrupted-In-Schizophrenia-1 (DISC1) interactome and mental disorders: impact of mouse models.
abstract: Disrupted-In-Schizophrenia-1 (DISC1) has captured much attention because it predisposes individuals to a wide range of mental illnesses. Notably, a number of genes encoding proteins interacting with DISC1 are also considered to be relevant risk factors of mental disorders. We reasoned that the understanding of DISC1-associated mental disorders in the context of network principles will help to address fundamental properties of DISC1 as a disease gene. Systematic integration of behavioural phenotypes of genetic mouse lines carrying perturbation in DISC1 interacting proteins would contribute to a better resolution of neurobiological mechanisms of mental disorders associated with the impaired DISC1 interactome and lead to a development of network medicine. This review also makes specific recommendations of how to assess DISC1 associated mental disorders in mouse models and discuss future directions.
authors.affiliation: Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada. Electronic address: lipina@lunenfeld.ca.
authors.forename: Tatiana V
authors.initials: TV
authors.lastname: Lipina
authors.affiliation: Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada; Departments of Medical Biophysics and Molecular & Medical Genetics, University of Toronto, Toronto, Ontario, Canada.
authors.forename: John C
authors.initials: JC
authors.lastname: Roder
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D001523:Mental Disorders / Q000235:genetics* / Q000503:physiopathology*; D051379:Mice; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000378:metabolism*
chemical_list: C412476:DISC1 protein, human; C498794:Disc1 protein, mouse; D009419:Nerve Tissue Proteins
keywords: Behavioural phenotype; DISC1 interactome; Genetic mouse models; Mental diseases network