title: Epigenetic control of skin and hair regeneration after wounding.
abstract: Skin wound healing is a complex regenerative phenomenon that can result in hair follicle neogenesis. Skin regeneration requires significant contribution from the immune system and involves substantial remodelling of both epidermal and dermal compartments. In this viewpoint, we consider epigenetic regulation of reepithelialization, dermal restructuring and hair neogenesis. Because little is known about the epigenetic control of these events, we have drawn upon recent epigenetic mapping and functional studies of homeostatic skin maintenance, epithelial-mesenchymal transition in cancer, and new works on regenerative dermal cell lineages and the epigenetic events that may shape their conversion into myofibroblasts. Finally, we speculate on how these various healing components might converge for wound-induced hair follicle neogenesis.
authors.affiliation: Department of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, CA, USA.
authors.forename: Maksim V
authors.initials: MV
authors.lastname: Plikus
authors.forename: Christian Fernando
authors.initials: CF
authors.lastname: Guerrero-Juarez
authors.forename: Elsa
authors.initials: E
authors.lastname: Treffeisen
authors.forename: Denise L
authors.initials: DL
authors.lastname: Gay
mesh_terms: D000818:Animals; D044127:Epigenesis, Genetic; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics; D006197:Hair / Q000502:physiology*; D006706:Homeostasis / Q000235:genetics*; D006801:Humans; D058628:Myofibroblasts / Q000502:physiology; D062326:Re-Epithelialization / Q000235:genetics*; D012867:Skin / Q000293:injuries*
keywords: epigenetic regulation; hair follicle; regeneration; stem cells; wound healing