title: Usefulness of serum bilirubin levels as a biomarker for long-term clinical outcomes after percutaneous coronary intervention.
abstract: The aim of this study was to evaluate the prognostic value of serum total bilirubin on the development of adverse outcomes after percutaneous coronary intervention (PCI) besides high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B type natriuretic peptide (NT-proBNP). Serum total bilirubin, hs-cTnT, and NT-proBNP were analyzed in 372 patients who underwent PCI. The primary endpoint was cardiac death. There were 21 events of cardiac death during a mean of 25.8 months of follow-up. When the serum total bilirubin cut-off level (median value) was set to 0.58 mg/dL using the receiver operating characteristic curve, the sensitivity was 95.2 % and the specificity was 51.0 % for differentiating between the group with cardiac death and the group without cardiac death. Kaplan-Meier analysis revealed that the lower serum total bilirubin group (<0.58 mg/dL) had a significantly higher cardiac death rate than the higher serum total bilirubin group (≥0.58 mg/dL) (10.4 vs. 0.6 %, log-rank: P = 0.0001). In conclusion, low serum total bilirubin is a predictive marker for cardiac death after PCI.
authors.affiliation: Department of Internal Medicine, Chosun University School of Medicine, 375 Seo-suk dong, Dong-Gu, Gwangju, 501-759, Republic of Korea.
authors.forename: Hyun-Wook
authors.initials: HW
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Chosun University School of Medicine, 375 Seo-suk dong, Dong-Gu, Gwangju, 501-759, Republic of Korea. dhchoi@chosun.ac.kr.
authors.forename: Dong-Hyun
authors.initials: DH
authors.lastname: Choi
authors.affiliation: Department of Biomaterials, Chosun University Graduate School, Gwangju, 501-759, Republic of Korea.
authors.forename: Leejin
authors.initials: L
authors.lastname: Lim
authors.affiliation: Department of Internal Medicine, Chosun University School of Medicine, 375 Seo-suk dong, Dong-Gu, Gwangju, 501-759, Republic of Korea.
authors.forename: Young-Min
authors.initials: YM
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Mokpo Jung-ang General Hospital, Mokpo, Republic of Korea.
authors.forename: Joon Tae
authors.initials: JT
authors.lastname: Kang
authors.affiliation: Department of Internal Medicine, Mokpo Jung-ang General Hospital, Mokpo, Republic of Korea.
authors.forename: Seung Seok
authors.initials: SS
authors.lastname: Chae
authors.affiliation: Department of Internal Medicine, Chosun University School of Medicine, 375 Seo-suk dong, Dong-Gu, Gwangju, 501-759, Republic of Korea.
authors.forename: Young-Jae
authors.initials: YJ
authors.lastname: Ki
authors.affiliation: Department of Biochemistry and Molecular Biology, Chosun University School of Medicine, Gwangju, 501-759, Republic of Korea.
authors.forename: Heesang
authors.initials: H
authors.lastname: Song
authors.affiliation: Department of Internal Medicine, Chosun University School of Medicine, 375 Seo-suk dong, Dong-Gu, Gwangju, 501-759, Republic of Korea.
authors.forename: Young-Youp
authors.initials: YY
authors.lastname: Koh
mesh_terms: D000368:Aged; D001663:Bilirubin / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D003643:Death; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects*; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D012372:ROC Curve; D056910:Republic of Korea; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; D020107:Troponin T; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D001663:Bilirubin
keywords: Bilirubin; Cardiac death; N-terminal pro-BNP; Percutaneous coronary intervention; Troponin T