title: [Comparative characteristics of genetic aberrations in glioblastomas in children and adults].
abstract: Glioblastomas in children and adults are a heterogeneous group of tumors that can be divided into at least three different subgroups: pediatric glioblastomas, IDH1-mutant glioblastomas in adults (the most favorable prognostic subtype), and IDH1-wild type glioblastomas in adults. According to the frequency of detected cytogenetic aberrations (amplification of the MYC/MYCN, EGFR and PDGRFA oncogenes, homozygous deletion of the CDKN2A gene, and deletion of the PTEN gene), pediatric glioblastomas bear analogy to the subgroup of IDH1-mutant glioblastomas in adults.
authors.forename: M V
authors.initials: MV
authors.lastname: Ryzhova
authors.forename: L V
authors.initials: LV
authors.lastname: Shishkina
authors.forename: O G
authors.initials: OG
authors.lastname: Zheludkova
authors.forename: A V
authors.initials: AV
authors.lastname: Golanov
authors.forename: S K
authors.initials: SK
authors.lastname: Gorelyshev
authors.forename: D I
authors.initials: DI
authors.lastname: Pitskhelauri
authors.forename: A Kh
authors.initials: AKh
authors.lastname: Bekiashev
authors.forename: G L
authors.initials: GL
authors.lastname: Kobiakov
authors.forename: O V
authors.initials: OV
authors.lastname: Absaliamova
authors.forename: R V
authors.initials: RV
authors.lastname: Sycheva
authors.forename: A G
authors.initials: AG
authors.lastname: Korshunov
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D005909:Glioblastoma / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics*
chemical_list: D009363:Neoplasm Proteins