title: Patient selection for personalized peptide receptor radionuclide therapy using Ga-68 somatostatin receptor PET/CT.
abstract: Neuroendocrine tumors are malignant solid tumors originating from neuroendocrine cells dispersed throughout the body. Differentiated neuroendocrine tumors overexpress somatostatin receptors (SSTRs), which enable the diagnosis using radiolabeled somatostatin analogues. Internalization and retention within the tumor cell are important for peptide receptor radionuclide therapy using the same peptide. The use of the same DOTA-peptide for SSTR PET/CT using (68)Ga and for peptide receptor radionuclide therapy using therapeutic radionuclides like (177)Lu and (90)Y offers a unique theranostic advantage.
authors.affiliation: THERANOSTICS Center for Molecular Radiotherapy and Molecular Imaging, ENETS Center of Excellence, Zentralklinik Bad Berka, Robert-Koch-Alle 9, 99437 Bad Berka, Germany. Electronic address: harshad.kulkarni@zentralklinik.de.
authors.forename: Harshad R
authors.initials: HR
authors.lastname: Kulkarni
authors.affiliation: THERANOSTICS Center for Molecular Radiotherapy and Molecular Imaging, ENETS Center of Excellence, Zentralklinik Bad Berka, Robert-Koch-Alle 9, 99437 Bad Berka, Germany.
authors.forename: Richard P
authors.initials: RP
authors.lastname: Baum
mesh_terms: D019788:Fluorodeoxyglucose F18; D005710:Gallium Radioisotopes / Q000627:therapeutic use*; D006801:Humans; D064847:Multimodal Imaging / Q000379:methods; D018358:Neuroendocrine Tumors / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D015282:Octreotide / Q000031:analogs & derivatives / Q000627:therapeutic use; D009942:Organometallic Compounds / Q000627:therapeutic use; D018579:Patient Selection; D049268:Positron-Emission Tomography / Q000379:methods; D057285:Precision Medicine; D019275:Radiopharmaceuticals / Q000627:therapeutic use*; D017481:Receptors, Somatostatin / Q000378:metabolism; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: C587879:68Ga-DOTA-octreotide; C499142:Ga(III)-DOTATOC; D005710:Gallium Radioisotopes; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; D017481:Receptors, Somatostatin; D019788:Fluorodeoxyglucose F18; C513399:gallium Ga 68 dotatate; D015282:Octreotide
keywords: Ga-68; PRRT; Somatostatin receptors