title: Relationships between blood Mg2+ and energy metabolites/enzymes after acute exhaustive swimming exercise in rats.
abstract: Magnesium (Mg) plays a central role in neuronal activity, cardiac excitability, neuromuscular transmission, muscular contraction, vasomotor tone, and blood pressure, all of which are significantly related to physical performance. To date, the available data about detection of blood total Mg (tMg; free-ionized, protein-bound, and anion-complex forms) are inconsistent, and there is limited information on blood free-ionized Mg (Mg(2+)) in relation to physical exercise. The aim of this study was to determine the biochemical changes related to energy metabolism after acute exhaustive swimming exercise (AESE) in rats in an attempt to correlate the role of blood Mg(2+) with metabolites/enzymes related to energy production. After AESE, blood Mg(2+), tMg, K(+), partial pressure of carbon dioxide, lactate, total protein (T-PRO), high-density lipoprotein (HDL), creatinine (CRE), blood urea nitrogen (BUN), uric acid (UA), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alanine phosphatase (ALP), lactate dehydrogenase (LDH), and creatinine kinase (CK) were significantly increased, whereas pH, partial pressure of oxygen, oxygen saturation, the Mg(2+)/tMg and Ca(2+)/Mg(2+) ratios, HCO3 (-), glucose, triglyceride (TG), and low-density lipoprotein (LDL) were significantly decreased. During AESE, lactate, T-PRO, albumin, AST, ALP, LDH, CK, CRE, BUN, and UA showed significant positive correlations with changes in blood Mg(2+), while glucose, TG, and LDL correlated to Mg(2+) in a negative manner. In conclusion, AESE induced increases in both blood Mg(2+) and tMg, accompanied by changes in blood metabolites and enzymes related to energy metabolism due to increased metabolic demands and mechanical damages.
authors.affiliation: Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Chonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do, 561-756, Republic of Korea.
authors.forename: Md Mahbubur
authors.initials: MM
authors.lastname: Rahman
authors.forename: Sei-Jin
authors.initials: SJ
authors.lastname: Lee
authors.forename: A-Reum
authors.initials: AR
authors.lastname: Mun
authors.forename: Gareeballah Osman
authors.initials: GO
authors.lastname: Adam
authors.forename: Ra-Mi
authors.initials: RM
authors.lastname: Park
authors.forename: Gi-Beum
authors.initials: GB
authors.lastname: Kim
authors.forename: Hyung-Sub
authors.initials: HS
authors.lastname: Kang
authors.forename: Jin-Shang
authors.initials: JS
authors.lastname: Kim
authors.forename: Shang-Jin
authors.initials: SJ
authors.lastname: Kim
authors.forename: Sung-Zoo
authors.initials: SZ
authors.lastname: Kim
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001806:Blood Urea Nitrogen; D002118:Calcium / Q000097:blood; D002245:Carbon Dioxide / Q000097:blood; D004734:Energy Metabolism / Q000502:physiology*; D004798:Enzymes / Q000097:blood*; D007770:L-Lactate Dehydrogenase / Q000097:blood; D019344:Lactic Acid / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008274:Magnesium / Q000097:blood*; D008297:Male; D010100:Oxygen / Q000097:blood; D010805:Physical Conditioning, Animal / Q000502:physiology*; D017207:Rats, Sprague-Dawley; D013550:Swimming / Q000502:physiology*; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood
chemical_list: D001786:Blood Glucose; D004798:Enzymes; D008077:Lipoproteins, LDL; D014280:Triglycerides; D002245:Carbon Dioxide; D014527:Uric Acid; D019344:Lactic Acid; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D008274:Magnesium; D010100:Oxygen; D002118:Calcium