title: An interleukin-6 receptor polymorphism is associated with opisthorchiasis-linked cholangiocarcinoma risk in Thailand.
abstract: The cholangiocarcinoma (CCA) is a relatively rare cancer worldwide but it is highly prevalent in Thailand where the liver fluke, Opisthorchis viverrini is endemic. There are reports that interleukin 6 (IL-6) may play an important role in the pathogenesis of opisthorchiasis associated CCA. Functionally, IL-6 can act on target cells through its receptor, IL-6R, and IL-6R polymorphisms may affect the functional activity of IL-6 leading to susceptibility to cholangiocarcinogenesis. Therefore, we assessed the association of the 48892 A/C (Asp358Ala) polymorphism in exon 9 of the IL-6R gene in 79 CCA cases compared to 80 healthy controls using the PCR- RFLP technique. The results showed significant differences between CCA cases and controls in overall genotype (p=0.001) and allele frequencies (p=0.0002). Chi-square for trend test revealed a significant association between genotype and CCA susceptibility (p=0.0002). The odds ratios (ORs) for genotype were 0.283 (95% CI=0.131-0.605, AC vs. AA; p=0.0003) and 0.206 (95% CI=0.196-1.245, CC vs. AA; p=0.0416), the OR for alleles was 0.347 (95% CI=0.187-0.633, allele C vs. allele A; p=0.0002) and that for the carrier C variant was 0.272 (95% CI=0.130-0.564; p=0.0001). This study demonstrated a close association between an IL-6R polymorphism, specifically higher A allele, and cholangiocarcinoma.
authors.affiliation: Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand E-mail : banchob@kku.ac.th.
authors.forename: Pokpong
authors.initials: P
authors.lastname: Prayong
authors.forename: Eimorn
authors.initials: E
authors.lastname: Mairiang
authors.forename: Chawalit
authors.initials: C
authors.lastname: Pairojkul
authors.forename: Yaovalux
authors.initials: Y
authors.lastname: Chamgramol
authors.forename: Pisaln
authors.initials: P
authors.lastname: Mairiang
authors.forename: Vajarabhongsa
authors.initials: V
authors.lastname: Bhudisawasdi
authors.forename: Banchob
authors.initials: B
authors.lastname: Sripa
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D018281:Cholangiocarcinoma / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009889:Opisthorchiasis / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D019947:Receptors, Interleukin-6 / Q000235:genetics*; D012306:Risk; D012307:Risk Factors; D013785:Thailand
chemical_list: D015850:Interleukin-6; D019947:Receptors, Interleukin-6