title: Enzymetically regulating the self-healing of protein hydrogels with high healing efficiency.
abstract: Enzyme-mediated self-healing of dynamic covalent bond-driven protein hydrogels was realized by the synergy of two enzymes, glucose oxidase (GOX) and catalase (CAT). The reversible covalent attachment of glutaraldehyde to lysine residues of GOX, CAT, and bovine serum albumin (BSA) led to the formation and functionalization of the self-healing protein hydrogel system. The enzyme-mediated protein hydrogels exhibit excellent self-healing properties with 100% recovery. The self-healing process was reversible and effective with an external glucose stimulus at room temperature.
authors.affiliation: State Key laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Road, Changchun 130012 (China).
authors.forename: Yuzhou
authors.initials: Y
authors.lastname: Gao
authors.forename: Quan
authors.initials: Q
authors.lastname: Luo
authors.forename: Shanpeng
authors.initials: S
authors.lastname: Qiao
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.forename: Zeyuan
authors.initials: Z
authors.lastname: Dong
authors.forename: Jiayun
authors.initials: J
authors.lastname: Xu
authors.forename: Junqiu
authors.initials: J
authors.lastname: Liu
mesh_terms: D000818:Animals; D002374:Catalase / Q000737:chemistry / Q000378:metabolism*; D002417:Cattle; D005949:Glucose Oxidase / Q000737:chemistry / Q000378:metabolism*; D020100:Hydrogels / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D015394:Molecular Structure; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000378:metabolism; D013696:Temperature
chemical_list: D020100:Hydrogels; D012710:Serum Albumin, Bovine; D005949:Glucose Oxidase; D002374:Catalase
keywords: dynamic covalent bonds; enzyme mediation; glucose oxidase; protein hydrogels; self-healing