title: Paraneoplastic autoimmune multiorgan syndrome (paraneoplastic pemphigus) with unusual manifestations and without detectable autoantibodies.
abstract: We describe a patient with paraneoplastic autoimmune multiorgan syndrome (PAMS) secondary to a lymphoblastic T- cell lymphoma who presented with a lichenoid dermatitis and vitiligo, later developing bronchiolitis obliterans and autoimmune hepatitis. Notably, he had no detectable autoantibodies. The development of vitiligo and autoimmune hepatic involvement probably indicate a role for cytotoxic T- cell lymphocytes in the pathogenesis of this syndrome.
authors.affiliation: Department of Dermatology, 12 de Octubre University Hospital, Madrid, Spain.
authors.forename: Jimena
authors.initials: J
authors.lastname: Sanz-Bueno
authors.forename: Daniella
authors.initials: D
authors.lastname: Cullen
authors.forename: Carlos
authors.initials: C
authors.lastname: Zarco
authors.forename: Francisco
authors.initials: F
authors.lastname: Vanaclocha
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage; D001323:Autoantibodies / Q000097:blood; D001327:Autoimmune Diseases / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D015458:Leukemia, T-Cell / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D010257:Paraneoplastic Syndromes / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D010392:Pemphigus / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D011241:Prednisone / Q000008:administration & dosage; D055815:Young Adult
chemical_list: D018931:Antineoplastic Agents, Hormonal; D001323:Autoantibodies; D011241:Prednisone