title: Encephalitis caused by human herpesvirus-6B in pancreas-after-kidney transplantation.
abstract: Human herpesvirus-6 (HHV-6) is a common pathogen among children, classically presenting with fever and rash that resolves without specific therapy. HHV-6 can be reactivated in the immunosuppressed patient. After bone marrow and solid organ transplantation, HHV-6 has been linked to various clinical syndromes, including undifferentiated febrile illness, encephalitis, myelitis, hepatitis, pneumonitis, and bone marrow suppression. However, HHV-6 encephalitis after pancreatic transplant has rarely been reported. Early diagnosis and treatment of HHV-6 encephalitis may be important for affected patients. We report the case of a 53-year-old pancreas-after-kidney transplant recipient who initially presented with high fever and confusion 3 weeks after operation. We managed to save the patient's life and preserve the pancreas graft function. We also review previously reported cases of HHV-6B encephalitis in solid organ transplant recipients.
authors.affiliation: Department of Transplant Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan; Department of Transplant Immunology, Nagoya University School of Medicine, Nagoya, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Watarai
authors.forename: N
authors.initials: N
authors.lastname: Goto
authors.forename: Y
authors.initials: Y
authors.lastname: Horikoshi
authors.forename: S
authors.initials: S
authors.lastname: Yamada
authors.forename: K
authors.initials: K
authors.lastname: Yasui
authors.forename: M
authors.initials: M
authors.lastname: Tsujita
authors.forename: T
authors.initials: T
authors.lastname: Hiramitsu
authors.forename: S
authors.initials: S
authors.lastname: Narumi
authors.forename: A
authors.initials: A
authors.lastname: Katayama
authors.forename: K
authors.initials: K
authors.lastname: Uchida
authors.forename: T
authors.initials: T
authors.lastname: Kobayashi
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D004660:Encephalitis / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D005260:Female; D015654:Herpesvirus 6, Human; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D016035:Pancreas Transplantation / Q000009:adverse effects*; D019349:Roseolovirus Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D000998:Antiviral Agents
keywords: HHV-6; encephalitis; human herpesvirus-6B; pancreas-after-kidney transplantation