title: [What's new in 2014 about anti-Müllerian hormone?].
abstract: The existence of the anti-Müllerian hormone (AMH) has been postulated by Professor Alfred Jost to explain the regression of the Müllerian ducts during male sexual differentiation. Since then, AMH has been purified, its gene and specific receptor, AMHR-II have been cloned. Further, the signaling pathways were identified and it has been observed that AMH was produced by the granulosa cells of growing follicles. From the 2000s, unexpected roles of AMH have been highlighted, reactivating international research on this hormone. It is now well established that AMH plays a key role in the follicular recruitment and development. Over the past years, serum AMH measurements have been proposed as a marker of the follicular ovarian status, and a predictor of assisted reproductive cycles. AMH is also useful to assess the effectiveness of treatment of some gynecological tumors. This article is a review of the past five years advances on the regulation of the expression of AMH and its specific receptor AMHR-II in female.
authors.affiliation: Service de médecine de la reproduction, hôpital Jean-Verdier, avenue du 14-Juillet, 93140 Bondy, France.
authors.forename: A
authors.initials: A
authors.lastname: Seroka-Vanhove
authors.affiliation: Service de médecine de la reproduction, hôpital Jean-Verdier, avenue du 14-Juillet, 93140 Bondy, France; Université Paris XIII, 93000 Bobigny, France.
authors.forename: C
authors.initials: C
authors.lastname: Sonigo
authors.affiliation: Service de médecine de la reproduction, hôpital Jean-Verdier, avenue du 14-Juillet, 93140 Bondy, France.
authors.forename: C
authors.initials: C
authors.lastname: Roche
authors.affiliation: Service de médecine de la reproduction, hôpital Jean-Verdier, avenue du 14-Juillet, 93140 Bondy, France; Université Paris XIII, 93000 Bobigny, France; Unité Inserm U1133, université Paris-Diderot, 75013 Paris, France. Electronic address: michael.grynberg@jvr.aphp.fr.
authors.forename: M
authors.initials: M
authors.lastname: Grynberg
mesh_terms: D054304:Anti-Mullerian Hormone / Q000378:metabolism / Q000502:physiology*; D005260:Female; D006801:Humans; D065851:Ovarian Reserve / Q000502:physiology*; D018000:Receptors, Peptide / Q000378:metabolism / Q000502:physiology*; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism / Q000502:physiology*
chemical_list: D018000:Receptors, Peptide; D018125:Receptors, Transforming Growth Factor beta; C084621:anti-Mullerian hormone receptor; D054304:Anti-Mullerian Hormone
keywords: AMHR-II; Anti-Müllerian hormone; Folliculogenesis; Folliculogénèse; Hormone anti-müllérienne; Ovarian reserve; Réserve ovarienne