title: Hypersensitivity to antiepileptic drugs.
abstract: Adverse reactions to antiepileptic drugs (AEDs) may lead to treatment failure, morbidity, and mortality. Drug hypersensitivity reactions (DHRs) are potentially fatal. AED DHRs present with a variety of clinical manifestations. The pathogenesis of AED DHRs has not been fully elucidated. Bioactivation, detoxification, covalent adduct formation, presentation to the immune system, and consequent formation of antibody and T-cell immune effectors have been suggested. This article summarizes the epidemiology, pathogenic mechanisms, risk factors, clinical features, and management of allergic reactions to the aromatic AEDs carbamazepine, phenytoin, and lamotrigine.
authors.affiliation: Department of Allergy and Clinical Immunology, Ajou University School of Medicine, 206 World cup-ro, Yeongtong-gu, Suwon 443-721, Republic of Korea.
authors.forename: Young-Min
authors.initials: YM
authors.lastname: Ye
authors.affiliation: Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore.
authors.forename: Bernard Yu-Hor
authors.initials: BY
authors.lastname: Thong
authors.affiliation: Department of Allergy and Clinical Immunology, Ajou University School of Medicine, 206 World cup-ro, Yeongtong-gu, Suwon 443-721, Republic of Korea. Electronic address: hspark@ajou.ac.kr.
authors.forename: Hae-Sim
authors.initials: HS
authors.lastname: Park
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects*; D019468:Disease Management; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology / Q000628:therapy*; D006801:Humans; D012307:Risk Factors
chemical_list: D000927:Anticonvulsants
keywords: Antiepileptic drugs; Drug hypersensitivity; Pharmacogenetics; Severe cutaneous adverse reactions