title: Transcriptional coregulators: emerging roles of SRC family of coactivators in disease pathology.
abstract: Transcriptional coactivators have evolved as an important new class of functional proteins that participate with virtually all transcription factors and nuclear receptors (NRs) to intricately regulate gene expression in response to a wide variety of environmental cues. Recent findings have highlighted that coactivators are important for almost all biological functions, and consequently, genetic defects can lead to severe pathologies. Drug discovery efforts targeting coactivators may prove valuable for treatment of a variety of diseases.
authors.affiliation: Department of Molecular and Cellular BiologyBaylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.
authors.forename: Subhamoy
authors.initials: S
authors.lastname: Dasgupta
authors.affiliation: Department of Molecular and Cellular BiologyBaylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA berto@bcm.edu.
authors.forename: Bert W
authors.initials: BW
authors.lastname: O'Malley
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D046912:Multiprotein Complexes / Q000378:metabolism; D011485:Protein Binding; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic; D015533:Transcriptional Activation
chemical_list: D046912:Multiprotein Complexes; D014157:Transcription Factors
keywords: hormone receptors; nuclear receptors; transcription; transcription factors