title: Synthesis and spectroscopy studies of the inclusion complex of 3-amino-5-methyl pyrazole with beta-cyclodextrin.
abstract: Amino pyrazole belongs to anti-inflammatory class, and is characterized by a low solubility in water. (In order to increase its solubility in water, inclusion complex of amino pyrazole with β-CD was obtained.) The inclusion complex obtained between AMP and β-cyclodextrin, was characterized by FT-IR, (1)H NMR, (1)H-(1)H NOESY, (13)C NMR, DEPT, XHCOR, spectra, through TG analysis, DTA, DSC and Scanning Electron Microscopy (SEM). The stoichiometry of inclusion complex is 1:1 (guest-host) and K stability is 1.1 × 10(4)M(-1).
authors.affiliation: Laboratory of Physics of Lamellaires Materials and Hybrids Nanomaterials, University of Carthage, Faculty of Sciences of Bizerte, Zarzouna 7021, Bizerte, Tunisia.
authors.forename: S
authors.initials: S
authors.lastname: Louiz
authors.affiliation: Laboratory of Synthesis and Nanomateriaux Structures, University of Carthage, Faculty of Sciences of Bizerte, Zarzouna 7021, Bizerte, Tunisia.
authors.forename: H
authors.initials: H
authors.lastname: Labiadh
authors.affiliation: Laboratory of Physics of Lamellaires Materials and Hybrids Nanomaterials, University of Carthage, Faculty of Sciences of Bizerte, Zarzouna 7021, Bizerte, Tunisia. Electronic address: abderrahim.raoudha@gmail.com.
authors.forename: R
authors.initials: R
authors.lastname: Abderrahim
mesh_terms: D060326:Chemistry Techniques, Synthetic; D003461:Crystallography; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008855:Microscopy, Electron, Scanning; D011720:Pyrazoles / Q000737:chemistry*; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D055672:Static Electricity; D013818:Thermogravimetry; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: C000601651:3-amino-5-methyl pyrazole; D011720:Pyrazoles; D047392:beta-Cyclodextrins; C031215:betadex
keywords: 3-Amino-5-methyl pyrazole; Inclusion complex; NMR spectroscopy; SEM; β-Cyclodextrin