title: Antinociceptive effect of 3-(4-fluorophenyl)-5-trifluoromethyl-1H-1-tosylpyrazole. A Celecoxib structural analog in models of pathological pain.
abstract: Pain is the most common complaint in the medical field and the identification of novel compounds that can effectively treat painful states without causing side effects remains a major challenge in biomedical research. The aim of the present study is to investigate the antinociceptive effect of 3-(4-fluorophenyl)-5-trifluoromethyl-1H-1-tosylpyrazole (FTosPz) in models of pathological pain in mice and compare these effects with those produced by Celecoxib. FTosPz (100-500 μmol/kg) or Celecoxib (26-260 μmol/kg) was administrated orally. The administration of either FTosPz or Celecoxib reduced the hyperalgesia but not the edema or leukocyte infiltration that was caused by Complete Freund's Adjuvant (CFA), used as an arthritis model. Oral administration of both FTosPz and Celecoxib also attenuated the postoperative hyperalgesia as well as the hyperalgesia caused by partial sciatic nerve ligation, used as a neuropathic pain model. FTosPz and Celecoxib produced antinociceptive effects without altering the locomotor activity of animals. Furthermore, FTosPz neither altered AST/ALT enzyme activity nor the urea/creatinine levels. Still, the FTosPz did not alter the COX-1 and COX-2 enzyme activities. Thus, FTosPz is an interesting prototype for the development of novel analgesic drugs.
authors.affiliation: Laboratório de Neurotoxicidade e Psicofarmacologia, Programa de Pós-graduação em Ciências Biológicas: Bioquímica Toxicológica, Universidade Federal de Santa Maria, Santa Maria, RS 97.105-900, Brazil; Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Santa Maria, Santa Maria, RS 97.105-900, Brazil. Electronic address: saramarchesan@hotmail.com.
authors.forename: Sara Marchesan
authors.initials: SM
authors.lastname: Oliveira
authors.affiliation: Laboratório de Neurotoxicidade e Psicofarmacologia, Programa de Pós-graduação em Ciências Biológicas: Bioquímica Toxicológica, Universidade Federal de Santa Maria, Santa Maria, RS 97.105-900, Brazil.
authors.forename: Cássia Regina
authors.initials: CR
authors.lastname: Silva
authors.affiliation: Núcleo de Química de Heterociclos (NUQUIMHE), Departamento de Química, Universidade Federal de Santa Maria, Santa Maria, RS 97.105-900, Brazil.
authors.forename: Alexandre Pereira
authors.initials: AP
authors.lastname: Wentz
authors.affiliation: Núcleo de Química de Heterociclos (NUQUIMHE), Departamento de Química, Universidade Federal de Santa Maria, Santa Maria, RS 97.105-900, Brazil.
authors.forename: Gisele R
authors.initials: GR
authors.lastname: Paim
authors.affiliation: Núcleo de Química de Heterociclos (NUQUIMHE), Departamento de Química, Universidade Federal de Santa Maria, Santa Maria, RS 97.105-900, Brazil.
authors.forename: Michele S
authors.initials: MS
authors.lastname: Correa
authors.affiliation: Núcleo de Química de Heterociclos (NUQUIMHE), Departamento de Química, Universidade Federal de Santa Maria, Santa Maria, RS 97.105-900, Brazil.
authors.forename: Hélio G
authors.initials: HG
authors.lastname: Bonacorso
authors.affiliation: Departamento de Farmacologia, Universidade Federal do Paraná, Curitiba, PR, Brazil.
authors.forename: Arthur S
authors.initials: AS
authors.lastname: Prudente
authors.affiliation: Departamento de Ciências Farmacêuticas, Universidade Estadual de Ponta Grossa, Ponta Grossa, PR, Brazil.
authors.forename: Michel Fleith
authors.initials: MF
authors.lastname: Otuki
authors.affiliation: Laboratório de Neurotoxicidade e Psicofarmacologia, Programa de Pós-graduação em Ciências Biológicas: Bioquímica Toxicológica, Universidade Federal de Santa Maria, Santa Maria, RS 97.105-900, Brazil; Departamento de Farmacologia, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.
authors.forename: Juliano
authors.initials: J
authors.lastname: Ferreira
mesh_terms: D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D000068579:Celecoxib; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D010146:Pain / Q000188:drug therapy*; D011720:Pyrazoles / Q000627:therapeutic use*; D013449:Sulfonamides / Q000627:therapeutic use*; D014105:Tosyl Compounds / Q000627:therapeutic use*
chemical_list: C539486:3-(4-fluorophenyl)-5-trifluoromethyl-1H-1-tosylpyrazole; D000700:Analgesics; D011720:Pyrazoles; D013449:Sulfonamides; D014105:Tosyl Compounds; D000068579:Celecoxib
keywords: Antinociception; Arthritis; Hyperalgesia; Neuropathy; Pyrazole; Surgery