title: Upper Extremity Multifocal Neuropathy in a 10-Year-Old Boy Associated With NS6S Disaccharide Antibodies.
abstract: We present a 10-year-old boy with a predominantly motor multifocal neuropathy with demyelinating and axonal changes with sensory involvement, affecting only one upper extremity. Laboratory studies revealed an elevated titer of immunoglobulin M (IgM) antibodies against the NS6S antigen. He responded to treatment with high dose intravenous immunoglobulins. Focal or multifocal immune-mediated neuropathies are not common in children and may be underdiagnosed.
authors.affiliation: Child Neurology Division, Department of Neurology, University of Wisconsin Hospital and Clinics, Madison, WI, USA Edelman@neurology.wisc.edu.
authors.forename: Frederick
authors.initials: F
authors.lastname: Edelman
authors.affiliation: Neurology Resident, Department of Neurology, University of Wisconsin Hospital and Clinics, Madison, WI, USA.
authors.forename: Elie
authors.initials: E
authors.lastname: Naddaf
authors.affiliation: Neuromuscular Division, Department of Neurology, University of Wisconsin Hospital and Clinics, Madison, WI, USA.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Waclawik
mesh_terms: D001323:Autoantibodies / Q000097:blood*; D002648:Child; D003711:Demyelinating Diseases / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D004187:Disaccharides / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007155:Immunologic Factors / Q000627:therapeutic use; D008297:Male; D009431:Neural Conduction; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D034941:Upper Extremity
chemical_list: D001323:Autoantibodies; D004187:Disaccharides; D007075:Immunoglobulin M; D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors
keywords: Lewis-Sumner syndrome; NS6S disaccharide antibodies; immune-mediated neuropathy; monomelic amyotrophy; multifocal motor neuropathy