title: Genetic association signal near NTN4 in Tourette syndrome.
abstract: Tourette syndrome (TS) is a neurodevelopmental disorder with a complex genetic etiology. Through an international collaboration, we genotyped 42 single nucleotide polymorphisms (p < 10(-3) ) from the recent TS genomewide association study (GWAS) in 609 independent cases and 610 ancestry-matched controls. Only rs2060546 on chromosome 12q22 (p = 3.3 × 10(-4) ) remained significant after Bonferroni correction. Meta-analysis with the original GWAS yielded the strongest association to date (p = 5.8 × 10(-7) ). Although its functional significance is unclear, rs2060546 lies closest to NTN4, an axon guidance molecule expressed in developing striatum. Risk score analysis significantly predicted case-control status (p = 0.042), suggesting that many of these variants are true TS risk alleles.
authors.affiliation: Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupoli, Greece.
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authors.lastname: Wolanczyk
authors.forename: Harvey
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authors.forename: I-Ching
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authors.lastname: Chou
authors.forename: Marco
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authors.lastname: Grados
authors.forename: Danielle
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authors.lastname: Posthuma
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authors.lastname: Rouleau
authors.forename: Harald
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authors.lastname: Aschauer
authors.forename: Nelson B
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authors.lastname: Freimer
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authors.lastname: Pauls
authors.forename: Nancy J
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authors.lastname: Cox
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mesh_terms: D000328:Adult; D016022:Case-Control Studies; D055106:Genome-Wide Association Study / Q000706:statistics & numerical data*; D006801:Humans; D009414:Nerve Growth Factors / Q000235:genetics*; D000075385:Netrins; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D005879:Tourette Syndrome / Q000235:genetics*
chemical_list: C498815:NTN4 protein, human; D009414:Nerve Growth Factors; D000075385:Netrins