title: [Genome-wide association study of high altitude pulmonary edema].
abstract: OBJECTIVE
  High altitue pulmonary edema (HAPE) impacts seriously people's health at high altitude. Screening of susceptibility genes for HAPE will be used for the evaluation and protection of susceptible people.
  
  
  METHODS
  We performed a genome-wide association study (GWAS) using Affymetrix SNP array 6.0 in 23 HAPE patients and 17 healthy controls. GO and Pathway analysis softwares were used to analyze and draw gene network.
  
  
  RESULTS
  Thirty-nine SNPs were found to be significantly different between case and control groups (P < 10(-4)). GO and Pathway analysis of 27 genes around the 39 SNPs indicated that these genes mainly participate in the regulating of cell proliferation, regulation of nitrogen compound metabolic process and G-protein coupled receptor protein signaling pathway and so on.
  
  
  CONCLUSIONS
  It suggests that these SNPs and genes found in this study may be associated with the susceptibility of HAPE.
authors.forename: Rui-Feng
authors.initials: RF
authors.lastname: Duan
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Chao-Liang
authors.initials: CL
authors.lastname: Long
authors.forename: Yan-Fang
authors.initials: YF
authors.lastname: Zhang
authors.forename: Wen-Yu
authors.initials: WY
authors.lastname: Cui
authors.forename: Yin-Hu
authors.initials: YH
authors.lastname: Wang
authors.forename: Hai
authors.initials: H
authors.lastname: Wang
mesh_terms: D000328:Adult; D000532:Altitude Sickness / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D006976:Hypertension, Pulmonary / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult