title: Association of mastocytosis with inflammatory joint diseases: a series of 31 patients.
abstract: OBJECTIVE
  We studied the clinical phenotypes and tolerance to treatments in a series of patients affected by both inflammatory joint diseases and mastocytosis.
  
  
  METHODS
  This retrospective multicenter study was conducted on behalf of 3 networks focused on mastocytosis, pediatric, and adults' inflammatory joint diseases. Patients who displayed both mastocytosis and inflammatory joint diseases were included.
  
  
  RESULTS
  A total of 31 patients were included. They had spondyloarthritis (SpA) (16 patients), rheumatoid arthritis (6 patients), juvenile idiopathic arthritis (2 patients), and undifferentiated arthritis (7 patients). The median ages at diagnosis of arthritis and mastocytosis were 44 and 40.5 years, respectively. Disease-modifying anti-rheumatic drugs (DMARDs) were required in 22 patients, comprising mostly methotrexate (13 patients), salazopyrin (8 patients), anti-tumor-necrosis-factor agents (7 patients), and corticosteroids (9 patients). They were well tolerated. Adverse events occurred in 2/24 patients receiving non-steroidal anti-inflammatory drugs. The prevalence of SpA among the 600 patients included in the mastocytosis cohort was 2.33%, which is significantly higher than the prevalence of SpA in the French population (p < 0.001).
  
  
  CONCLUSIONS
  This study suggests that mastocytosis is associated with a higher prevalence of SpA than expected, and that DMARDs, notably anti-TNFα agents, are well tolerated in patients with mastocytosis. Mast cells might be involved in the development of SpA.
authors.affiliation: Department of Pediatric Immunology and Rheumatology, INSERM U768, Hôpital Necker Enfants Malades (AP-HP), Paris 75015, France; Institut Imagine, Université Sorbonne Paris cité, Hôpital Necker-Enfants Malades (AP-HP), Paris, France. Electronic address: brigitte.bader-meunier@nck.aphp.fr.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Bader-Meunier
authors.affiliation: Department of Dermatology, Université Paul Sabatier, CHU de Toulouse, France.
authors.forename: Cristina
authors.initials: C
authors.lastname: Bulai Livideanu
authors.affiliation: Department of Internal Medicine, CHU Avicenne, (AP-HP), Bobigny, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Larroche
authors.affiliation: Department of Internal Medicine, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Université de Lyon, Pierre Bénite, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Durieu
authors.affiliation: Department of Rheumatology, Hôpital du Mans, Le Mans, France.
authors.forename: Laure
authors.initials: L
authors.lastname: Artru
authors.affiliation: Department of Internal Medicine, CHU Angers, Angers, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Beucher
authors.affiliation: Department of Rheumatology, CHD Vendée, La Roche sur Yon, France.
authors.forename: Grégoire
authors.initials: G
authors.lastname: Cormier
authors.affiliation: Department of Rheumatology, CHRU Brest, Brest, France.
authors.forename: Divi
authors.initials: D
authors.lastname: Cornec
authors.affiliation: Department of Rheumatology, Hôpital de Bigorre, Tarbes, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Delarco
authors.affiliation: Department of Rheumatology, Hopital G. Montpied, CHU Clermont-Ferrand, Clermont-Ferrand, France.
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Dubost
authors.affiliation: Department of Internal Medicine, Clinique Mutualiste Beau Soleil, Montpellier, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Fontaine
authors.affiliation: Department of Hematology, CHU de Limoges, Limoges Cedex, France.
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Gourin
authors.affiliation: Department of Rheumatology, CHRU Hautepierre, Strasbourg, France.
authors.forename: Rose-Marie
authors.initials: RM
authors.lastname: Javier
authors.affiliation: Department of Internal Medicine, Hôpital d'Instruction des Armées Sainte Anne, Toulon CEDEX, France.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: de Jauréguiberry
authors.affiliation: Department of Internal Medicine, CHD les Oudairies, La Roche sur Yon, France.
authors.forename: Hervé
authors.initials: H
authors.lastname: Maisonneuve
authors.affiliation: Clinical Investigation Center Biotherapy INSERM CBT-506, CHRU de Besançon, Besançon, France; Department of Rheumatology, CHRU de Besançon, Besançon, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Toussirot
authors.affiliation: Laboratory of Hematology, CHU de Brest, Brest, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Ugo
authors.affiliation: Department of Pediatrics, CHU Estaing, Clermont-Ferrand, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Echaubard
authors.affiliation: Department of Pediatric Immunology and Rheumatology, INSERM U768, Hôpital Necker Enfants Malades (AP-HP), Paris 75015, France.
authors.forename: Nizar
authors.initials: N
authors.lastname: Mahlaoui
authors.affiliation: Department of Hematology, Hôpital Necker EnfantsMalades (AP-HP), Paris, France; Institut Imagine, Université Sorbonne Paris cité, Hôpital Necker-Enfants Malades (AP-HP), Paris, France.
authors.forename: Achille
authors.initials: A
authors.lastname: Aouba
authors.affiliation: Department of Dermatology and Pediatric Dermatology, Hôpital Necker Enfants Malades (AP-HP), Paris, France; Institut Imagine, Université Sorbonne Paris cité, Hôpital Necker-Enfants Malades (AP-HP), Paris, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Bodemer
authors.affiliation: Department of Rheumatology, Hôpital Cochin, Paris Descartes University, Paris, France.
authors.forename: Karine
authors.initials: K
authors.lastname: Briot
authors.affiliation: Department of Hematology, Hôpital Necker EnfantsMalades (AP-HP), Paris, France; Institut Imagine, Université Sorbonne Paris cité, Hôpital Necker-Enfants Malades (AP-HP), Paris, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Frenzel
authors.affiliation: Department of Infectious Diseases and Tropical Medicine, Hôpital Necker Enfants Malades (AP-HP), Paris, France; Institut Imagine, Université Sorbonne Paris cité, Hôpital Necker-Enfants Malades (AP-HP), Paris, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Lortholary
authors.affiliation: Department of Hematology, Hôpital Necker EnfantsMalades (AP-HP), Paris, France; Institut Imagine, Université Sorbonne Paris cité, Hôpital Necker-Enfants Malades (AP-HP), Paris, France.
authors.forename: Marie-Olivia
authors.initials: MO
authors.lastname: Chandesris
authors.affiliation: Department of Hematology, Hôpital Necker EnfantsMalades (AP-HP), Paris, France; Institut Imagine, Université Sorbonne Paris cité, Hôpital Necker-Enfants Malades (AP-HP), Paris, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Hermine
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001688:Biological Products / Q000627:therapeutic use; D015897:Comorbidity; D005602:France; D006801:Humans; D008407:Mast Cells / Q000473:pathology / Q000502:physiology; D008415:Mastocytosis / Q000453:epidemiology* / Q000473:pathology*; D008875:Middle Aged; D010641:Phenotype; D015995:Prevalence; D012189:Retrospective Studies; D012216:Rheumatic Diseases / Q000188:drug therapy / Q000453:epidemiology* / Q000473:pathology*; D055815:Young Adult
chemical_list: D018501:Antirheumatic Agents; D001688:Biological Products
keywords: Anti-TNF alpha; Arthritis; Mastocytosis; Spondyloarthropathy