title: Agelamadins A and B, dimeric bromopyrrole alkaloids from a marine sponge Agelas sp.
abstract: Two structurally unique dimeric bromopyrrole alkaloids, agelamadins A (1) and B (2), were isolated from a marine sponge Agelas sp. Agelamadins A (1) and B (2) have a structure consisting of an agelastatin-like tetracyclic moiety and an oroidin-like linear moiety in common. The structures of 1 and 2 were elucidated on the basis of spectroscopic analysis. The antimicrobial activity and cytotoxicity of agelamadins A (1) and B (2) were evaluated.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Hokkaido University , Sapporo 060-0812, Japan.
authors.forename: Taishi
authors.initials: T
authors.lastname: Kusama
authors.forename: Naonobu
authors.initials: N
authors.lastname: Tanaka
authors.forename: Kanae
authors.initials: K
authors.lastname: Sakai
authors.forename: Tohru
authors.initials: T
authors.lastname: Gonoi
authors.forename: Jane
authors.initials: J
authors.lastname: Fromont
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Kashiwada
authors.forename: Jun'ichi
authors.initials: J
authors.lastname: Kobayashi
mesh_terms: D047230:Agelas / Q000737:chemistry*; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D001412:Bacillus subtilis / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006842:Hydrocarbons, Brominated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007624:KB Cells; D051379:Mice; D008826:Microbial Sensitivity Tests; D016982:Micrococcus luteus / Q000187:drug effects; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000470:Alkaloids; D006842:Hydrocarbons, Brominated; C000592080:agelamadin A; C000592081:agelamadin B