title: Evaluation of carrier added and no carrier added 90Y-EDTMP as bone seeking therapeutic radiopharmaceutical.
abstract: The optimum conditions to label ethylenediaminetetramethylene phosphonate (EDTMP) compound with (90)y as a potential candidate for bone metastases therapy were investigated. Yttrium-90 is a pure β-emitter and can be obtained by (89)y (n,γ) (90)y nuclear reaction in a reactor or from an in-house generator system ((90)sr(90)y). The preparation of (90)Y-EDTMPis described using (90)y, which was obtained from neutron irradiation of y2o3 as well as from a laboratory scale organic resin-based (90)sr--(90)y generator. Because of the radiolabeling yield of 90Y-EDTMP on ligand/metal molar ratio, incubation time and ph was evaluated. Under optimum parameters, the radiolabeling yields of (90)Y-EDTMP were <95% for no-carrier-added as well as carrier-added (90)y. The biodistribution of no-carrier-added and carrier-added (90)Y-EDTMP complexes in rats was identical. The results indicate that (90)y (carrier-added)-edtmp is also an effective bone pain palliation agent because of its rapid blood clearance, greater uptake in bones and little absorption in soft tissues.
authors.affiliation: Isotope Production Division, Pakistan Institute of Nuclear Science and Technology, P.O. Nilore, Islamabad, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Khalid
authors.affiliation: Department of Chemistry, Government College University, Faisalabad, Pakistan.
authors.forename: Tanveer Hussain
authors.initials: TH
authors.lastname: Bokhari
authors.affiliation: Isotope Production Division, Pakistan Institute of Nuclear Science and Technology, P.O. Nilore, Islamabad, Pakistan.
authors.forename: Mushtaq
authors.initials: M
authors.lastname: Ahmad
authors.affiliation: Department of Chemistry and Biochemistry, University of agriculture, Faisalabad, Pakistan.
authors.forename: Haq Nawaz
authors.initials: HN
authors.lastname: Bhatti
authors.affiliation: Department of Chemistry and Biochemistry, University of agriculture, Faisalabad, Pakistan.
authors.forename: Munawar
authors.initials: M
authors.lastname: Iqbal
authors.affiliation: Department of Chemistry, Government College University, Faisalabad, Pakistan.
authors.forename: Abdul
authors.initials: A
authors.lastname: Ghaffar
authors.affiliation: College of Pharmacy, Government College University, Faisalabad, Pakistan.
authors.forename: Muhammad Imran
authors.initials: MI
authors.lastname: Qadir
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000532:radiotherapy* / Q000556:secondary; D004337:Drug Carriers; D007553:Isotope Labeling; D008297:Male; D009943:Organophosphorus Compounds / Q000627:therapeutic use*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution; D015021:Yttrium Radioisotopes / Q000627:therapeutic use*
chemical_list: D004337:Drug Carriers; D009943:Organophosphorus Compounds; D019275:Radiopharmaceuticals; D015021:Yttrium Radioisotopes; C018940:(ethylenedinitrilo)-tetramethylenephosphonic acid