title: A case of brain and leptomeningeal metastases from urothelial carcinoma of the bladder.
abstract: Brain metastases are unusual from urethelial carcinoma of bladder and particularly the occurrence of leptomeningeal metastases is extremely rare, with few cases described in the literature. We present a case of a 45-year-old man with a rare brain metastases as the first metastatic manifestation secondary to urethelial carcinoma of bladder followed by leptomeningeal metastases without any other organ involvement. Eleven months after the diagnosis of high-grade urethelial carcinoma of bladder (T2N0M0), the patient was detected having brain metastases by MRI. FDG PET/CT images for the metastatic evaluation showed no abnormal FDG uptake elsewhere in the body except the brain. Histopathology examination from brain lesion demonstrated the cerebral lesion to be a metastatic urothelial carcinoma. Two months later, the patient was diagnosed to have leptomeningeal metastases by MRI. Our patient's condition gradually worsened, and he died 3 months after the diagnosis of leptomeningeal metastases.
authors.affiliation: Department of Nuclear Medicine, Faculty of Medicine, Baskent University, Ankara, Turkey. Electronic address: sevaler@yahoo.com.
authors.forename: S
authors.initials: S
authors.lastname: Erhamamcı
authors.affiliation: Department of Nuclear Medicine, Faculty of Medicine, Baskent University, Ankara, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Reyhan
authors.affiliation: Department of Radiology, Faculty of Medicine, Baskent University, Ankara, Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Altinkaya
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis / Q000556:secondary*; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis / Q000556:secondary*; D003952:Diagnostic Imaging; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000556:secondary*; D008875:Middle Aged; D001743:Urinary Bladder; D001749:Urinary Bladder Neoplasms / Q000473:pathology*
keywords: Brain metastases; Carcinoma urotelial de vejiga; FDG; Leptomeningeal metastases; Metástasis cerebral; Metástasis leptomeníngea; PET/CT; PET/TC; Urothelial bladder carcinoma