title: Remodeling of the piriform cortex after lesion in adult rodents.
abstract: Denervation of the piriform cortex by bulbotomy causes a series of important cellular changes in the inhibitory interneurons of layer I and transsynaptic apoptosis of a large number of pyramidal neurons in outer layer II within 24 h. In this study, we report that following the marked loss of neurons in outer layer II, the piriform cortex is reconstituted by the addition of newly formed neurons that restore the number to a preinjury level within 30 days. We provide evidence that the number of newly divided neuronal progenitors increases after injury and further show that a population of doublecortin-positive cells that resides in the piriform cortex decreases after injury. Taken together, these findings suggest that the piriform cortex has significant neurogenic potential that is activated following sensory denervation and may contribute toward the replacement of neurons in outer layer II.
authors.affiliation: aDepartment of Pathology, Division of Neuropathology Departments of bNeurology cPsychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Sharyn L
authors.initials: SL
authors.lastname: Rossi
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Mahairaki
authors.forename: Lijun
authors.initials: L
authors.lastname: Zhou
authors.forename: Yeajin
authors.initials: Y
authors.lastname: Song
authors.forename: Vassilis E
authors.initials: VE
authors.lastname: Koliatsos
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D001973:Bromodeoxyuridine; D003714:Denervation; D000089622:Doublecortin Domain Proteins; D000089662:Doublecortin Protein; D007150:Immunohistochemistry; D008297:Male; D008822:Mice, Transgenic; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000378:metabolism; D058953:Neural Stem Cells / Q000473:pathology / Q000502:physiology; D055495:Neurogenesis / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000473:pathology* / Q000502:physiology*; D009479:Neuropeptides / Q000235:genetics / Q000378:metabolism; D066195:Piriform Cortex / Q000473:pathology* / Q000503:physiopathology*; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: C000714848:Dcx protein, rat; D000089622:Doublecortin Domain Proteins; D000089662:Doublecortin Protein; D008869:Microtubule-Associated Proteins; D009479:Neuropeptides; D001973:Bromodeoxyuridine