title: Chondrogenic differentiation of human adipose-derived stem cells: a new path in articular cartilage defect management?
abstract: According to data published by the Centers for Disease Control and Prevention, over 6 million people undergo a variety of medical procedures for the repair of articular cartilage defects in the U.S. each year. Trauma, tumor, and age-related degeneration can cause major defects in articular cartilage, which has a poor intrinsic capacity for healing. Therefore, there is substantial interest in the development of novel cartilage tissue engineering strategies to restore articular cartilage defects to a normal or prediseased state. Special attention has been paid to the expansion of chondrocytes, which produce and maintain the cartilaginous matrix in healthy cartilage. This review summarizes the current efforts to generate chondrocytes from adipose-derived stem cells (ASCs) and provides an outlook on promising future strategies.
authors.affiliation: Department of Plastic Surgery, Hand Surgery, Burn Center, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074 Aachen, Germany ; Institute of Biochemistry and Molecular Cell Biology, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074 Aachen, Germany.
authors.forename: Jan-Philipp
authors.initials: JP
authors.lastname: Stromps
authors.affiliation: Department of Plastic Surgery, Hand Surgery, Burn Center, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074 Aachen, Germany.
authors.forename: Nora Emilie
authors.initials: NE
authors.lastname: Paul
authors.affiliation: Department of Orthopedic Surgery, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074 Aachen, Germany.
authors.forename: Björn
authors.initials: B
authors.lastname: Rath
authors.affiliation: Department of Plastic Surgery, Hand Surgery, Burn Center, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074 Aachen, Germany.
authors.forename: Mahtab
authors.initials: M
authors.lastname: Nourbakhsh
authors.affiliation: Institute of Biochemistry and Molecular Cell Biology, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074 Aachen, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Bernhagen
authors.affiliation: Department of Plastic Surgery, Hand Surgery, Burn Center, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074 Aachen, Germany.
authors.forename: Norbert
authors.initials: N
authors.lastname: Pallua
mesh_terms: D017667:Adipocytes / Q000166:cytology*; D000818:Animals; D002454:Cell Differentiation; D002478:Cells, Cultured; D019902:Chondrocytes / Q000166:cytology*; D020219:Chondrogenesis / Q000502:physiology*; D050724:Fractures, Cartilage / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D033581:Stem Cell Transplantation / Q000379:methods; D013234:Stem Cells / Q000166:cytology*; D023822:Tissue Engineering / Q000379:methods