title: Neurovascular coupling in pregnancy and the risk of preeclampsia.
abstract: OBJECTIVE
  This study investigated whether a short testing of neurovascular coupling during midterm pregnancy could identify women at risk for subsequent preeclampsia.
  
  
  METHODS
  Transcranial Doppler sonography of the posterior cerebral artery during a brief visual stimulation was analyzed in 68 women at midterm pregnancy, the primary clinical end point was preeclampsia.
  
  
  RESULTS
  Women with bilateral notching of the uterine arteries showed an exaggerated visually evoked blood flow increase and longer time-to-peak. Neurovascular coupling was not significantly associated with the occurrence of preeclampsia.
  
  
  CONCLUSIONS
  Neurovascular coupling was altered in women with impaired uteroplacentar vasoregulation but not a significant predictor of preeclampsia.
authors.affiliation: From the Departments of Neurology (W.G.J., R.E., E.E., C.W., M.R.), Pediatrics and Adolescent Medicine (W.G.J.), and Obstetrics and Gynecology (S.M., B.G., H.P.), University of Freiburg, Freiburg, Germany; and Department of Statistics, University of Ulm, Ulm, Germany (A.A.).
authors.forename: Wibke G
authors.initials: WG
authors.lastname: Janzarik
authors.affiliation: From the Departments of Neurology (W.G.J., R.E., E.E., C.W., M.R.), Pediatrics and Adolescent Medicine (W.G.J.), and Obstetrics and Gynecology (S.M., B.G., H.P.), University of Freiburg, Freiburg, Germany; and Department of Statistics, University of Ulm, Ulm, Germany (A.A.).
authors.forename: Renata
authors.initials: R
authors.lastname: Ehmann
authors.affiliation: From the Departments of Neurology (W.G.J., R.E., E.E., C.W., M.R.), Pediatrics and Adolescent Medicine (W.G.J.), and Obstetrics and Gynecology (S.M., B.G., H.P.), University of Freiburg, Freiburg, Germany; and Department of Statistics, University of Ulm, Ulm, Germany (A.A.).
authors.forename: Elena
authors.initials: E
authors.lastname: Ehlers
authors.affiliation: From the Departments of Neurology (W.G.J., R.E., E.E., C.W., M.R.), Pediatrics and Adolescent Medicine (W.G.J.), and Obstetrics and Gynecology (S.M., B.G., H.P.), University of Freiburg, Freiburg, Germany; and Department of Statistics, University of Ulm, Ulm, Germany (A.A.).
authors.forename: Arthur
authors.initials: A
authors.lastname: Allignol
authors.affiliation: From the Departments of Neurology (W.G.J., R.E., E.E., C.W., M.R.), Pediatrics and Adolescent Medicine (W.G.J.), and Obstetrics and Gynecology (S.M., B.G., H.P.), University of Freiburg, Freiburg, Germany; and Department of Statistics, University of Ulm, Ulm, Germany (A.A.).
authors.forename: Sebastian
authors.initials: S
authors.lastname: Mayer
authors.affiliation: From the Departments of Neurology (W.G.J., R.E., E.E., C.W., M.R.), Pediatrics and Adolescent Medicine (W.G.J.), and Obstetrics and Gynecology (S.M., B.G., H.P.), University of Freiburg, Freiburg, Germany; and Department of Statistics, University of Ulm, Ulm, Germany (A.A.).
authors.forename: Boris
authors.initials: B
authors.lastname: Gabriel
authors.affiliation: From the Departments of Neurology (W.G.J., R.E., E.E., C.W., M.R.), Pediatrics and Adolescent Medicine (W.G.J.), and Obstetrics and Gynecology (S.M., B.G., H.P.), University of Freiburg, Freiburg, Germany; and Department of Statistics, University of Ulm, Ulm, Germany (A.A.).
authors.forename: Cornelius
authors.initials: C
authors.lastname: Weiller
authors.affiliation: From the Departments of Neurology (W.G.J., R.E., E.E., C.W., M.R.), Pediatrics and Adolescent Medicine (W.G.J.), and Obstetrics and Gynecology (S.M., B.G., H.P.), University of Freiburg, Freiburg, Germany; and Department of Statistics, University of Ulm, Ulm, Germany (A.A.).
authors.forename: Heinrich
authors.initials: H
authors.lastname: Prömpeler
authors.affiliation: From the Departments of Neurology (W.G.J., R.E., E.E., C.W., M.R.), Pediatrics and Adolescent Medicine (W.G.J.), and Obstetrics and Gynecology (S.M., B.G., H.P.), University of Freiburg, Freiburg, Germany; and Department of Statistics, University of Ulm, Ulm, Germany (A.A.). matthias.reinhard@uniklinik-freiburg.de.
authors.forename: Matthias
authors.initials: M
authors.lastname: Reinhard
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity; D002560:Cerebrovascular Circulation / Q000502:physiology; D005260:Female; D006439:Hemodynamics; D006801:Humans; D010920:Placenta / Q000098:blood supply; D020769:Posterior Cerebral Artery / Q000000981:diagnostic imaging / Q000503:physiopathology; D011225:Pre-Eclampsia / Q000175:diagnosis*; D011247:Pregnancy; D011248:Pregnancy Complications; D016896:Treatment Outcome; D017585:Ultrasonography, Doppler, Transcranial / Q000379:methods*; D055988:Uterine Artery; D014599:Uterus / Q000098:blood supply; D055815:Young Adult
keywords: preeclampsia