title: Primary diffuse leptomeningeal gliomatosis: An autopsy case report.
abstract: Primary diffuse leptomeningeal gliomatosis (PDLG) is a rare condition, characterized by infiltration of the meninges by glial cells without evidence of the primary tumor in the brain or spinal cord parenchyma. Glioma arising primarily from the leptomeninges is extremely rare and often diagnosed only in post mortem examination and the diagnosis may be missed in meningeal biopsy. We describe a young female who presented with symptoms of raised intracranial pressure with imaging evidence of diffuse leptomeningeal enhancement in whom autopsy confirmed the diagnosis of PDLG. Our case illustrates the diagnostic difficulties in making the pre-mortem diagnosis even with multiple cerebrospinal fluid cytologies and leptomeningeal biopsy.
authors.affiliation: Department of Neurology, Nizam's Institute of Medical Sciences, Hyderabad, India.
authors.forename: Shaik Afshan
authors.initials: SA
authors.lastname: Jabeen
authors.affiliation: Department of Neurology, Nizam's Institute of Medical Sciences, Hyderabad, India.
authors.forename: Arikapadu Haritha
authors.initials: AH
authors.lastname: Chowdary
authors.affiliation: Department of Neurology, Nizam's Institute of Medical Sciences, Hyderabad, India.
authors.forename: Rukmini Mridula
authors.initials: RM
authors.lastname: Kandadai
authors.affiliation: Department of Pathology, Nizam's Institute of Medical Sciences, Hyderabad, India.
authors.forename: Megha S
authors.initials: MS
authors.lastname: Uppin
authors.affiliation: Department of Neurology, Nizam's Institute of Medical Sciences, Hyderabad, India.
authors.forename: Angamattu Kanikannan
authors.initials: AK
authors.lastname: Meena
authors.affiliation: Department of Neurology, Nizam's Institute of Medical Sciences, Hyderabad, India.
authors.forename: Rupam
authors.initials: R
authors.lastname: Borgohain
authors.affiliation: Department of Pathology, Nizam's Institute of Medical Sciences, Hyderabad, India.
authors.forename: Challa
authors.initials: C
authors.lastname: Sundaram
keywords: Chronic meningitis; leptomeningeal gliomatosis; meningeal biopsy; neoplastic meningitis