title: Correlates of gait speed in advanced knee osteoarthritis.
abstract: OBJECTIVE
  This study aims to evaluate correlates of gait speed, a measure of disability, in older adults with advanced knee osteoarthritis (OA) and chronic pain.
  Baseline data were analyzed from a clinical trial of 190 participants aged >50 with advanced knee OA (according to clinical and radiographic American College of Rheumatology criteria) and chronic pain. Data included 4-meter gait speed, quality of life (Short Form Health Survey 36 global health subscale), knee pain (Western Ontario and McMasters Universities Osteoarthritis Index [WOMAC]), depressive symptoms (Center for Epidemiologic Studies Depression Scale), coping strategies (catastrophizing subscale and Cognitive Strategies Questionnaire), self-efficacy (Athritis Self-efficacy Scale [ASES]), comorbidity (Cumulative Illness Rating Scale), analgesic use, and pain comorbidities (location, frequency, and intensity). A multivariable regression model was used to investigate these variables as they relate to gait speed.
  
  
  RESULTS
  In the univariate analysis, the following variables were associated with gait speed: knee pain (per WOMAC), age, depressive symptoms, global health, catastrophizing, ASES function and other, comorbidity, and opioid use (all P values <0.05). In the fully adjusted multivariate model, controlling for knee pain, significant associations between gait speed and age (β = -0.006; P < 0.001), ASES function (β = 0.003; P < 0.001), and opioid use (β = -0.082; P = 0.009) persisted. The correlation between opioid dose and gait speed (among opioid users) was not statistically significant (r = 0.04; P = 0.81).
  
  
  CONCLUSIONS
  In a cross-sectional study of older adults with advanced knee OA and chronic pain, we found that age, arthritis function self-efficacy, and opioid use (but not dose) were significantly associated with decreased gait speed.
authors.affiliation: Department of Medicine (Geriatrics), University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
authors.forename: Zachary A
authors.initials: ZA
authors.lastname: Marcum
authors.forename: Hanzi Lena
authors.initials: HL
authors.lastname: Zhan
authors.forename: Subashan
authors.initials: S
authors.lastname: Perera
authors.forename: Charity G
authors.initials: CG
authors.lastname: Moore
authors.forename: G Kelley
authors.initials: GK
authors.lastname: Fitzgerald
authors.forename: Debra K
authors.initials: DK
authors.lastname: Weiner
mesh_terms: D000367:Age Factors; D000368:Aged; D000701:Analgesics, Opioid / Q000627:therapeutic use; D059350:Chronic Pain / Q000188:drug therapy / Q000209:etiology* / Q000523:psychology; D015897:Comorbidity; D003430:Cross-Sectional Studies; D004185:Disability Evaluation; D005260:Female; D005684:Gait; D006801:Humans; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000150:complications* / Q000188:drug therapy / Q000523:psychology
chemical_list: D000701:Analgesics, Opioid
keywords: Aged; Analgesic; Gait Speed; Osteoarthritis