title: TM4SF5-mediated protein-protein networks and tumorigenic roles.
abstract: Transmembrane 4 L six family member 5 (TM4SF5), as a membrane glycoprotein with 4 transmembrane domains, is similar to the tetraspanins in terms of membrane topology and plays important roles in tumorigenesis and tumor metastasis. Especially, TM4SF5 appears to form a massive protein-protein complex consisting of diverse membrane proteins and/or receptors in addition to cytosolic signaling molecules to regulate their signaling activities during the pathological processes. TM4SF5 is shown to interact with integrins α2, α5, and β1, EGFR, IL6R, CD151, focal adhesion kinase (FAK), and c-Src. This review focuses on the significance of the interactions with regards to TM4SF5-positive tumorigenesis and metastasis.
authors.affiliation: Department of Pharmacy, Research Institute of Pharmaceutical Sciences, Tumor Microenvironment Global Core Research Center, Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University, Seoul 151-742, Korea.
authors.forename: Jung Weon
authors.initials: JW
authors.lastname: Lee
mesh_terms: D000081247:CSK Tyrosine-Protein Kinase; D066246:ErbB Receptors / Q000737:chemistry / Q000378:metabolism; D051416:Focal Adhesion Protein-Tyrosine Kinases / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000737:chemistry / Q000378:metabolism; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism*; D060066:Protein Interaction Maps; D018121:Receptors, Cytokine / Q000737:chemistry / Q000378:metabolism; D059470:Tetraspanins / Q000737:chemistry / Q000378:metabolism; D019061:src-Family Kinases / Q000737:chemistry / Q000378:metabolism
chemical_list: D016023:Integrins; D008565:Membrane Proteins; D018121:Receptors, Cytokine; C111029:TM4SF5 protein, human; D059470:Tetraspanins; D066246:ErbB Receptors; D000081247:CSK Tyrosine-Protein Kinase; D051416:Focal Adhesion Protein-Tyrosine Kinases; D019061:src-Family Kinases; C000631346:CSK protein, human