title: Thrombolysis of occluded femoropopliteal graft with locally delivered human plasmin.
abstract: BACKGROUND
  Acute lower limb ischemia results from thrombosis or embolization of diseased native artery or previously implanted bypass graft. When this occurs, several options are available to restore blood flow: catheter-directed thrombolysis, mechanical thrombectomy or open surgery. Fundamental reasons to apply percutaneous interventions are avoiding open procedures in high risk patients, and avoiding difficult dissection through scar tissue.
  
  
  METHODS
  A 67-year-old male was admitted at our Institution for critical limb ischemia. After performed angiography the diagnosis of occluded femoropopliteal graft was established. Occlusion was resolved by catheter-directed thrombolysis with plasmin. Culprit lesions were treated by angioplasty.
  
  
  CONCLUSIONS
  Our patient underwent a successful thrombolysis of occluded femoropopliteal graft with locally-delivered human plasmin.
authors.forename: Dragoslav
authors.initials: D
authors.lastname: Nenezić
authors.forename: Djordje
authors.initials: D
authors.lastname: Radak
authors.forename: Predrag
authors.initials: P
authors.lastname: Gajin
authors.forename: Slobodan
authors.initials: S
authors.lastname: Tanasković
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Novaković
authors.forename: Predrag
authors.initials: P
authors.lastname: Matić
mesh_terms: D000368:Aged; D019917:Blood Vessel Prosthesis Implantation; D005263:Femoral Artery / Q000000981:diagnostic imaging / Q000601:surgery* / Q000637:transplantation; D005341:Fibrinolysin / Q000008:administration & dosage*; D006083:Graft Occlusion, Vascular / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D015552:Injections, Intralesional; D007511:Ischemia / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000601:surgery; D008297:Male; D011150:Popliteal Artery / Q000000981:diagnostic imaging / Q000601:surgery* / Q000637:transplantation; D011859:Radiography; D015912:Thrombolytic Therapy / Q000379:methods*; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000601:surgery
chemical_list: D005341:Fibrinolysin