title: Chemical components of Ardisia splendens leaves and their activity against coxsackie A16 viruses.
abstract: Using a combination of chromatographic methods, one new flavonol glycoside, myricetin 3,7-di-O-alpha-L-rhamnopyranoside (1), and nine known compounds myricitrin (2), quercetin 3,7-di-O-alpha-L-rhamnopyranoside (3), quercitrin (4), desmanthin-l (5), myricetin 3-O-(3"-O-galloyl)-alpha-L-rhamnopyranoside (6), (+)-catechin (7), benzyl O-1-D-glucopyranoside (8), 2-phenylethyl O-beta-D-glucopyranoside (9), and corilagin (10) were isolated from the leaves of Ardisia splendens Pit. Based on an in vitro test against Coxsackie viruses A16 by SRB assay, only compounds 2, 5, and 10 exhibited activity against Coxsackie viruses A16 with IC50 values of 40.1, 32.2, and 30.5 microM, respectively. This result suggested that compounds 2, 5, and 10 might be potential agents for treating hand, foot and mouth diseases.
authors.forename: Thi Hong
authors.initials: TH
authors.lastname: Van Nguyen
authors.forename: Trinh Anh
authors.initials: TA
authors.lastname: Vien
authors.forename: Nguyen Xuan
authors.initials: NX
authors.lastname: Nhiem
authors.forename: Phan
authors.initials: P
authors.lastname: Van Kiem
authors.forename: Chau
authors.initials: C
authors.lastname: Van Minh
authors.forename: Pham Quoc
authors.initials: PQ
authors.lastname: Long
authors.forename: Luu Tuan
authors.initials: LT
authors.lastname: Anh
authors.forename: Nguyen Manh
authors.initials: NM
authors.lastname: Cuong
authors.forename: Jae-Hyoung
authors.initials: JH
authors.lastname: Song
authors.forename: Hyun-Jeong
authors.initials: HJ
authors.lastname: Ko
authors.forename: Nanyoung
authors.initials: N
authors.lastname: Kim
authors.forename: Seon Ju
authors.initials: SJ
authors.lastname: Park
authors.forename: Seung Hyun
authors.initials: SH
authors.lastname: Kim
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031644:Ardisia / Q000737:chemistry*; D004770:Enterovirus / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D000998:Antiviral Agents