title: Development and formulation of metformin (Antidiabetic) effervescent Granules: to increase patient compliance and its stability study.
abstract: Convenience of administration and patient compliance are gaining importance in the formulation of dosage forms. Many patients, like elderly people and person with dysphagia find difficulty to swallow the tablets and thus do not comply with prescriptions. So the present study was conducted to develop and formulate metformin effervescent granules. The stability study was carried out for 24 weeks (168 days) at temperatures of 4°C, Room temperature, 40°C & 60°C and at the end, the %age of drug remaining in the formulation was determined. The results showed that the formulation of metformin effervescent granules were remained best stable at 4°C in refrigerator, as the %age of drug remaining is not decreased more than 5% and the formulation stored at room temperature, was also found to be very close to the standard at the end of 24 weeks. It is concluded from the study that granules may be another dosage form to use as antidiabetic pharmaceutical product.
authors.affiliation: Faculty of Pharmacy, University of Sargodha, Sargodha, Pakistan.
authors.forename: Saeedur Rashid
authors.initials: SR
authors.lastname: Nazir
authors.affiliation: Faculty of Pharmacy, University of Sargodha, Sargodha, Pakistan.
authors.forename: Ghazala
authors.initials: G
authors.lastname: Ambreen
authors.affiliation: Faculty of Pharmacy, University of Sargodha, Sargodha, Pakistan.
authors.forename: Hafiz Muhammad
authors.initials: HM
authors.lastname: Irfan
authors.affiliation: Faculty of Pharmacy, University of Sargodha, Sargodha, Pakistan.
authors.forename: Sajid
authors.initials: S
authors.lastname: Bashir
authors.affiliation: Drugs Control Authority, Pakistan.
authors.forename: Asim
authors.initials: A
authors.lastname: Rauf
mesh_terms: D002626:Chemistry, Pharmaceutical; D004355:Drug Stability; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry*; D055118:Medication Adherence; D008687:Metformin / Q000737:chemistry*
chemical_list: D007004:Hypoglycemic Agents; D008687:Metformin