title: [Circulating tumor cells: cornerstone of personalized medicine].
abstract: Cancer treatment has evolved toward personalized medicine. It is mandatory for clinicians to ascertain tumor biological features in order to optimize patients' treatment. Identification and characterization of circulating tumor cells demonstrated a prognostic value in many solid tumors. Here, we describe the main technologies for identification and characterization of circulating tumor cells and their clinical application in gynecologic and breast cancers.
authors.affiliation: Département de Genetic Medicine et Obstetrics and Gynecology, laboratoire cellules souches et microenvironnement, Weill Cornell Medical College, NY, États-Unis; Département de chirurgie gynécologique, hôpital Arnaud-de-Villeneuve, CHRU, université Montpellier 1, 34093 Montpellier, France. Electronic address: jat2021@qatar-med.cornell.edu.
authors.forename: A
authors.initials: A
authors.lastname: Rafii
authors.affiliation: Département de Genetic Medicine et Obstetrics and Gynecology, laboratoire cellules souches et microenvironnement, Weill Cornell Medical College, NY, États-Unis.
authors.forename: F
authors.initials: F
authors.lastname: Vidal
authors.affiliation: Département de chirurgie gynécologique, hôpital Arnaud-de-Villeneuve, CHRU, université Montpellier 1, 34093 Montpellier, France.
authors.forename: G
authors.initials: G
authors.lastname: Rathat
authors.affiliation: Laboratoire cellules circulantes rares humaines, département de biopathologie cellulaire et tissulaire des tumeurs, institut de médecine régénératrice et biothérapie, hôpital Saint-Éloi, CHRU, université Montpellier 1, 80, avenue Augustin-Fliche, Montpellier, France; EA2415 épidémiologie, biostatistiques et santé publique, institut universitaire de recherche clinique, 641, avenue du Doyen-Gaston-Giraud, 34093 Montpellier, France.
authors.forename: C
authors.initials: C
authors.lastname: Alix-Panabières
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology / Q000628:therapy; D005260:Female; D005833:Genital Neoplasms, Female / Q000235:genetics / Q000473:pathology / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D009362:Neoplasm Metastasis / Q000473:pathology; D009360:Neoplastic Cells, Circulating / Q000473:pathology; D057285:Precision Medicine; D011379:Prognosis; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D014408:Biomarkers, Tumor
keywords: Biopsie liquide; Cellules tumorales circulantes; Circulating tumor cells; Liquid biopsy; Personalized medicine; Personnalisation traitement