title: Green tea, black tea, and oolong tea polyphenols reduce visceral fat and inflammation in mice fed high-fat, high-sucrose obesogenic diets.
abstract: Green tea (GT) and caffeine in combination were shown to increase energy expenditure and fat oxidation, but less is known about the effects of black tea (BT) and oolong tea (OT). This study investigated whether decaffeinated polyphenol extracts from GT, BT, and OT decrease body fat and inflammation in male C57BL/6J mice fed high-fat/high-sucrose [HF/HS (32% energy from fat, 25% energy from sucrose)] diets. Mice were fed either an HF/HS diet with 0.25% of polyphenol from GT, OT, or BT or a low-fat/high-sucrose [LF/HS (10.6% energy from fat, 25% energy from sucrose)] diet for 20 wk. Monomeric tea polyphenols were found in the liver and adipose tissue of mice fed the HF/HS diet with GT polyphenols (GTPs) and OT polyphenols (OTPs) but not BT polyphenols (BTPs). Treatment with GTPs, OTPs, BTPs, and an LF/HS diet led to significantly lower body weight, total visceral fat volume by MRI, and liver lipid weight compared with mice in the HF/HS control group. Only GTPs reduced food intake significantly by ∼10%. GTP, BTP, and LF/HS-diet treatments significantly reduced serum monocyte chemotactic protein-1 (MCP-1) compared with HF/HS controls. In mesenteric fat, monocyte chemotactic protein-1 (Mcp1) gene expression was significantly decreased by treatment with GTPs, BTPs, OTPs, and an LF/HS diet and in liver tissue by GTP and BTP treatments. Mcp1 gene expression in epididymal fat was significantly decreased by the BTP and LF/HS diet interventions. In epididymal fat, consistent with an anti-inflammatory effect, adiponectin gene expression was significantly increased by GTPs and OTPs. Angiogenesis during adipose tissue expansion is anti-inflammatory by maintaining adipocyte perfusion. We observed significantly increased gene expression of vascular endothelial growth factor A by GTPs and vascular endothelial growth factor receptor 2 by BTPs and the LF/HS diet and a decrease in pigment epithelium-derived factor gene expression by OTPs and BTPs. In summary, all 3 tea polyphenol extracts induced weight loss and anti-inflammatory and angiogenic effects, although the tissue content of polyphenols differed significantly.
authors.affiliation: Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA dheber@mednet.ucla.edu.
authors.forename: David
authors.initials: D
authors.lastname: Heber
authors.affiliation: Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA.
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA.
authors.forename: Jieping
authors.initials: J
authors.lastname: Yang
authors.affiliation: Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA.
authors.forename: Janice E
authors.initials: JE
authors.lastname: Ma
authors.affiliation: Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA.
authors.forename: Susanne M
authors.initials: SM
authors.lastname: Henning
authors.affiliation: Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA.
authors.forename: Zhaoping
authors.initials: Z
authors.lastname: Li
mesh_terms: D052242:Adiponectin / Q000378:metabolism; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D028241:Camellia sinensis / Q000737:chemistry*; D018932:Chemokine CCL2 / Q000235:genetics / Q000378:metabolism; D004032:Diet / Q000009:adverse effects*; D004041:Dietary Fats / Q000009:adverse effects; D019422:Dietary Sucrose / Q000009:adverse effects; D004435:Eating / Q000187:drug effects; D005136:Eye Proteins / Q000378:metabolism; D007249:Inflammation / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D050152:Intra-Abdominal Fat / Q000378:metabolism*; D008297:Male; D008810:Mice, Inbred C57BL; D018919:Neovascularization, Physiologic / Q000187:drug effects; D009414:Nerve Growth Factors / Q000378:metabolism; D056128:Obesity, Abdominal / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D059808:Polyphenols / Q000494:pharmacology / Q000627:therapeutic use*; D015843:Serpins / Q000378:metabolism; D013662:Tea / Q000737:chemistry; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000378:metabolism; D015431:Weight Loss / Q000187:drug effects; D000099174:Pigment Epithelium-Derived Factor
chemical_list: D052242:Adiponectin; D000893:Anti-Inflammatory Agents; D018932:Chemokine CCL2; D004041:Dietary Fats; D019422:Dietary Sucrose; D005136:Eye Proteins; D009414:Nerve Growth Factors; D010936:Plant Extracts; D059808:Polyphenols; D015843:Serpins; D013662:Tea; D042461:Vascular Endothelial Growth Factor A; D040301:Vascular Endothelial Growth Factor Receptor-2; D000099174:Pigment Epithelium-Derived Factor; C491768:Ccl2 protein, mouse