title: Formulation and pharmacokinetics of gelucire solid dispersions of flurbiprofen.
abstract: BACKGROUND
  Development of solid dispersions is to improve the therapeutic efficacy by increasing the drug solubility, dissolution rate, bioavailability as well as to attain rapid onset of action.
  
  
  OBJECTIVE
  The present research deals with the development of solid dispersions of flurbiprofen which is poorly water soluble to improve the solubility and dissolution rate using gelucires.
  
  
  METHODS
  In this study, solid dispersions were prepared following solvent evaporation method using gelucire 44/14 and gelucire 50/13 as carriers in different ratios. Then the formulations were evaluated for different physical parameters, solubility studies, DSC, FTIR studies and in vitro dissolution studies to select the best formulation that shows rapid dissolution rate and finally subjected to pharmacokinetic studies.
  
  
  CONCLUSIONS
  From the in vitro dissolution study, formulation F3 showed the better improvement in solubility and dissolution rate. From the pharmacokinetic evaluation, the control tablets produced peak plasma concentration (Cmax) of 9140.84 ± 614.36 ng/ml at 3 h Tmax and solid dispersion tablets showed Cmax = 11 445.46 ± 149.23 ng/ml at 2 h Tmax. The area under the curve for the control and solid dispersion tablets was 31 495.16 ± 619.92 and 43 126.52 ± 688.89 ng h/ml and the mean resident time was 3.99 and 3.68 h, respectively.
  
  
  CONCLUSIONS
  From the above results, it is concluded that the formulation of gelucire 44/14 solid dispersions is able to improve the solubility, dissolution rate as well as the absorption rate of flurbiprofen than pure form of drug.
authors.affiliation: Department of Pharmaceutics, Sri Shivani College of Pharmacy , Warangal, Andhara Pradesh , India .
authors.forename: Bhaskar
authors.initials: B
authors.lastname: Daravath
authors.forename: Rama Rao
authors.initials: RR
authors.lastname: Tadikonda
authors.forename: Sateesh Kumar
authors.initials: SK
authors.lastname: Vemula
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000493:pharmacokinetics; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers / Q000737:chemistry / Q000493:pharmacokinetics; D005223:Fats / Q000737:chemistry* / Q000493:pharmacokinetics*; D005480:Flurbiprofen / Q000737:chemistry* / Q000493:pharmacokinetics*; D008297:Male; D009821:Oils / Q000737:chemistry* / Q000493:pharmacokinetics*; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000493:pharmacokinetics*; D011817:Rabbits; D012995:Solubility
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D005223:Fats; D009821:Oils; C104509:gelucire 44-14; C071184:Gelucire 50-13; D011092:Polyethylene Glycols; D005480:Flurbiprofen
keywords: Control tablet; dissolution rate; peak plasma concentration; solubility studies; solvent evaporation method