title: Platelet-Rich Plasma in Treatment of Zoledronic Acid-Induced Bisphosphonate-related Osteonecrosis of the Jaws.
abstract: BACKGROUND
  Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a well-known challenging entity warranting management. Platelet-Rich Plasma (PRP) plays an important role in bone biology by enhancing bone repair and regeneration.
  
  
  OBJECTIVE
  The aim of this animal study was to evaluate the effects of PRP on zoledronic acid-induced BRONJ.
  
  
  METHODS
  Seven rats were given 0.04 mg Zoledronic acid intravenously once a week for five weeks. Two weeks later, the animals underwent extraction of their first lower molars, bilaterally. After clinical confirmation of the osteonecrosis, PRP was injected randomly into one of the extraction sockets of each rat. Three weeks later, all rats were sacrificed in order to obtain histological sections. The analysis of epithelialization was performed by McNamar's test, and the analysis of osteogenesis and angiogenesis was performed by the Wilcoxon Sign Rank test. P value was set at 0.05.
  
  
  RESULTS
  We found no significant differences between the two groups regarding the amount of epithelialization, angiogenesis or sequestrum formation (P > 0.05), but a significant difference was seen between the two groups regarding the amount of existing vital bone (P < 0.05).
  
  
  CONCLUSIONS
  Our study demonstrates positive results (preservation or regeneration of bone) using PRP in treatment of BRONJ. Although PRP may enhance osseous regeneration, long-term follow-ups are required to confirm its benefits.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Buali Hospital, Azad University of Medical Sciences, Tehran, IR Iran.
authors.forename: Farzin
authors.initials: F
authors.lastname: Sarkarat
authors.affiliation: Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran ; Department of Maxillofacial Surgery, Azad University of Medical Sciences, Tehran, IR Iran.
authors.forename: Mohammad Hosein
authors.initials: MH
authors.lastname: Kalantar Motamedi
authors.affiliation: Department of Oral and Maxillofacial Pathology, Dental Branch, Azad University of Medical Sciences, Tehran, IR Iran.
authors.forename: Jahanfar
authors.initials: J
authors.lastname: Jahanbani
authors.affiliation: Private Practice, Tehran, IR Iran.
authors.forename: Dena
authors.initials: D
authors.lastname: Sepehri
authors.affiliation: Department of Oral and Maxillofacial Surgery, Buali Hospital, Azad University of Medical Sciences, Tehran, IR Iran.
authors.forename: Roozbeh
authors.initials: R
authors.lastname: Kahali
authors.affiliation: School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Nematollahi
keywords: Bisphosphonate; Bisphosphonate-Related Osteonecrosis of the Jaw; Osteonecrosis; Osteoporosis; Platelet-Rich Plasma; Zoledronic Acid