title: Sinonasal anatomical variations: their relationship with chronic rhinosinusitis and effect on the severity of disease-a computerized tomography assisted anatomical and clinical study.
abstract: The anatomy of the sinonasal area has a very wide rage of anatomical variations. The significance of these anatomical variations in pathogenesis of rhinosinusitis, which is the commonest disease in the region, is still unclear. The aims of the study were to compare the rate of sinonasal anatomical variations with development and severity of chronic rhinosinusitis patients. CT scan of paranasal sinuses images of 99 individuals were retrospectively reviewed. 65 cases of chronic rhinosinusitis (study group) who had undergone endoscopic sinus surgery were compared with 34 cases without chronic rhinosinusitis (control group). Also in study group Lund-Mackay score of the sinus disease were calculated and compared to the rate of related anatomical variations. There were 74 (74.7 %) males and 25 (25.2 %) females with ages ranging from 13 to 70 years (mean 32.2 years). The anatomical variations recorded were: Septal deviation 47 (72.3) in study and 25 (73.5 %) in control group, concha bullosa 27 (41.5 %) in study and 18 (52.9 %) in control group, overpneumatized ethmoid bulla 17 (26.1 %) in study and 14 (41.1 %) in control group, pneumatized uncinate 3 (4.6 %) in study and 3 (8.8 %) in control group, agger nasi 42 (64.6 %) in study and 19 (55.8 %) in control group, paradoxical middle turbinates 9 (13.8 %) in study and 4 (11.7 %) in control group, Onodi cell 6 (9.2 %) in study and 2 (5.8 %) in control group, Haller's cells (infraorbital ethmoid cell) 9 (13.8 %) in study and 7 (20.5 %) in control group. None of these results were statistically significant between study and control group (p > 0.05). Lund-Mackay score (which was assumed to show the severity of the disease) of the maxillary, ethmoid and frontal sinus were calculated and compared to rate of septal deviation, concha bullosa, agger nasi cells. No significant correlation was conducted (p > 0.05). The results of study showed no statistically significant correlation between sinonasal anatomical variations and pathologies of the paranasal sinus. Also these anatomical variations did not increase the severity of pre-existing sinusitis significantly.
  
  
  METHODS
  This is a retrospective cohort study (2b).
authors.affiliation: Department of Otorhinolaryngology Kayseri, Kayseri Develi State Hospital, Kayseri, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Kaygusuz
authors.affiliation: Department of Otorhinolaryngology, Bursa Sevket Yilmaz Training and Research Hospital, 16800 Yıldırım, Bursa, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Haksever
authors.affiliation: Department of Otorhinolaryngology, Bursa Sevket Yilmaz Training and Research Hospital, 16800 Yıldırım, Bursa, Turkey.
authors.forename: Davut
authors.initials: D
authors.lastname: Akduman
authors.affiliation: Department of Otorhinolaryngology, Bursa Sevket Yilmaz Training and Research Hospital, 16800 Yıldırım, Bursa, Turkey.
authors.forename: Sündüs
authors.initials: S
authors.lastname: Aslan
authors.affiliation: Department of Otorhinolaryngology, Bilecik State Hospital, Bilecik, Turkey.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Sayar
keywords: Anatomical variations; Chronic rhinosinusitis; Computed tomography; Endoscopic sinus surgery; Paranasal sinuses