title: Interaction of tryptophan and related compounds with oxygen- and carbon-centered radicals.
abstract: Effects of tryptophan, 5-hydroxytryptophan, serotonin, and melatonin on final product formation during radiolysis of deaerated and oxygen-saturated ethanol and aqueous 1M ethanol solutions were studied. The named amino acids were found to be capable of adding α-hydroxyethyl radicals, thereby suppressing recombination reactions of these species. Unlike melatonin, tryptophan, 5-hydroxytryptophan, and serotonin were able to reduce oxygen-centered radicals being formed on radiation-chemical oxidation of ethanol in the presence of oxygen via electron transfer from the amine nitrogen lone pair.
authors.affiliation: Department of Radiation Chemistry, Belarusian State University , Minsk , Republic of Belarus.
authors.forename: R L
authors.initials: RL
authors.lastname: Sverdlov
authors.forename: S D
authors.initials: SD
authors.lastname: Brinkevich
authors.forename: O I
authors.initials: OI
authors.lastname: Shadyro
mesh_terms: D006916:5-Hydroxytryptophan / Q000737:chemistry; D000975:Antioxidants / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D005609:Free Radicals / Q000737:chemistry; D008550:Melatonin / Q000737:chemistry; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000737:chemistry*; D012701:Serotonin / Q000737:chemistry; D014364:Tryptophan / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D017382:Reactive Oxygen Species; D012701:Serotonin; D002244:Carbon; D014364:Tryptophan; D006916:5-Hydroxytryptophan; D008550:Melatonin
keywords: carbon-centered radicals; neurodegenerative disorders; oxygen-centered radicals; steady-state radiolysis; tryptophan