title: Influence of age and gender on Doppler index of diastolic function in Chinese hypertensive patients.
abstract: OBJECTIVE
  This paper explores age- and gender-specific changes in Doppler echocardiographic index-E' of left ventricular diastolic function.
  
  
  METHODS
  The study involved 366 hypertensive patients (197 men and 169 women) who were aged from 20 to 90 years (mean 58.60 ± 15.68 years), without a diagnosis of any other disease. Early diastolic mitral inflow velocity (E), late diastolic mitral annular velocity (A), and E/A ratio were measured with pulse wave Doppler. Early diastolic mitral annular velocity (E') and E/E' ratios were measured with tissue Doppler imaging of lateral mitral annulus. Diastolic indices were highly correlated with age.
  
  
  RESULTS
  Among those aged 20-29, E' was significantly higher in female than in male. In patients aged 30-39, 40-49, 50-59, 60-69 and 70-79 years, E' was similar in both genders. Among those aged 80-89 years, E' was significantly lower in female than in male. Overall (n = 366) predictors of the lowest quartile of E' (E' < 8.00 cm/s) were age (P < 0.0001; χ(2) = 67.35; OR 1.28; 95% CI 1.26-1.30) and female gender (P < 0.05; χ(2) = 5.76; OR 1.56; 95% CI 1.19-1.94).
  
  
  CONCLUSIONS
  Age-related changes in diastolic indices correlated with gender among hypertensive patients. Diastolic function deteriorated more significantly among elderly women compared with elderly men. The study may explain the increased incidence of diastolic heart failure in elderly women with hypertension.
authors.affiliation: Department of Cardiology, Peking University Third Hospital, 49 Huayuan-Bei Road, Beijing, 100191, China.|Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Beijing, 100191, China.|Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, 100191, China.
authors.forename: D
authors.initials: D
authors.lastname: Zhu
authors.affiliation: Department of Cardiology, Peking University Third Hospital, 49 Huayuan-Bei Road, Beijing, 100191, China. baoxiachen@163.com.|Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Beijing, 100191, China. baoxiachen@163.com.|Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, 100191, China. baoxiachen@163.com.
authors.forename: B
authors.initials: B
authors.lastname: Chen
authors.affiliation: Department of Cardiology, Peking University Third Hospital, 49 Huayuan-Bei Road, Beijing, 100191, China.|Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Beijing, 100191, China.|Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, 100191, China.
authors.forename: X
authors.initials: X
authors.lastname: Feng
authors.affiliation: Department of Cardiology, Peking University Third Hospital, 49 Huayuan-Bei Road, Beijing, 100191, China.|Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Beijing, 100191, China.|Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, 100191, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Cardiology, Peking University Third Hospital, 49 Huayuan-Bei Road, Beijing, 100191, China.|Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Beijing, 100191, China.|Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, 100191, China.
authors.forename: W
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Cardiology, Peking University Third Hospital, 49 Huayuan-Bei Road, Beijing, 100191, China.|Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Beijing, 100191, China.|Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, 100191, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Nie
authors.affiliation: Department of Cardiology, Peking University Third Hospital, 49 Huayuan-Bei Road, Beijing, 100191, China.|Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Beijing, 100191, China.|Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, 100191, China.
authors.forename: X
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Cardiology, Peking University Third Hospital, 49 Huayuan-Bei Road, Beijing, 100191, China.|Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Beijing, 100191, China.|Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, 100191, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Department of Cardiology, Peking University Third Hospital, 49 Huayuan-Bei Road, Beijing, 100191, China.|Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Beijing, 100191, China.|Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, 100191, China.
authors.forename: W
authors.initials: W
authors.lastname: Gao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003971:Diastole; D015150:Echocardiography, Doppler / Q000379:methods*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D015994:Incidence; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000000981:diagnostic imaging*; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging*; D016277:Ventricular Function, Left; D055815:Young Adult
keywords: Aging; Echocardiography; Left ventricular diastolic function; Women