title: Voluntary exercise promotes beneficial anti-aging mechanisms in SAMP8 female brain.
abstract: Regular physical exercise mediates health and longevity promotion involving Sirtuin 1 (SIRT1)-regulated pathways. The anti-aging activity of SIRT1 is achieved, at least in part, by means of fine-tuning the adenosine monophosphate (AMP)-activated protein kinase (AMPK) pathway by preventing the transition of an originally pro-survival program into a pro-aging mechanism. Additionally, SIRT1 promotes mitochondrial function and reduces the production of reactive oxygen species (ROS) through regulating peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), the master controller of mitochondrial biogenesis. Here, by using senescence-accelerated mice prone 8 (SAMP8) as a model for aging, we determined the effect of wheel-running as a paradigm for long-term voluntary exercise on SIRT1-AMPK pathway and mitochondrial functionality measured by oxidative phosphorylation (OXPHOS) complex content in the hippocampus and cortex. We found differential activation of SIRT1 in both tissues and hippocampal-specific activation of AMPK. These findings correlated well with significant changes in OXPHOS in the hippocampal, but not in the cerebral cortex, area. Collectively, the results revealed greater benefits of the exercise in the wheel-running intervention in a murine model of senescence, which was directly related with mitochondrial function and which was mediated through the modulation of SIRT1 and AMPK pathways.
authors.affiliation: Unitat de Farmacologia i Farmacognòsia. Facultat de Farmàcia, Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028, Barcelona, Spain.
authors.forename: Sergi
authors.initials: S
authors.lastname: Bayod
authors.forename: Carolina
authors.initials: C
authors.lastname: Guzmán-Brambila
authors.forename: Sandra
authors.initials: S
authors.lastname: Sanchez-Roige
authors.forename: Jaume F
authors.initials: JF
authors.lastname: Lalanza
authors.forename: Perla
authors.initials: P
authors.lastname: Kaliman
authors.forename: Daniel
authors.initials: D
authors.lastname: Ortuño-Sahagun
authors.forename: Rosa M
authors.initials: RM
authors.lastname: Escorihuela
authors.forename: Mercè
authors.initials: M
authors.lastname: Pallàs
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism; D000375:Aging / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D000818:Animals; D001921:Brain / Q000254:growth & development / Q000378:metabolism* / Q000502:physiology; D005260:Female; D051379:Mice; D009928:Organ Specificity; D010085:Oxidative Phosphorylation; D005082:Physical Exertion; D056564:Sirtuin 1 / Q000235:genetics / Q000378:metabolism
chemical_list: D055372:AMP-Activated Protein Kinases; C470545:Sirt1 protein, mouse; D056564:Sirtuin 1