title: Zymomonas mobilis: a novel platform for future biorefineries.
abstract: Biosynthesis of liquid fuels and biomass-based building block chemicals from microorganisms have been regarded as a competitive alternative route to traditional. Zymomonas mobilis possesses a number of desirable characteristics for its special Entner-Doudoroff pathway, which makes it an ideal platform for both metabolic engineering and commercial-scale production of desirable bio-products as the same as Escherichia coli and Saccharomyces cerevisiae based on consideration of future biomass biorefinery. Z. mobilis has been studied extensively on both fundamental and applied level, which will provide a basis for industrial biotechnology in the future. Furthermore, metabolic engineering of Z. mobilis for enhancing bio-ethanol production from biomass resources has been significantly promoted by different methods (i.e. mutagenesis, adaptive laboratory evolution, specific gene knock-out, and metabolic engineering). In addition, the feasibility of representative metabolites, i.e. sorbitol, bionic acid, levan, succinic acid, isobutanol, and isobutanol produced by Z. mobilis and the strategies for strain improvements are also discussed or highlighted in this paper. Moreover, this review will present some guidelines for future developments in the bio-based chemical production using Z. mobilis as a novel industrial platform for future biofineries.
authors.affiliation: Biogas Institute of Ministry of Agriculture, Biomass Energy Technology Research Centre, Section 4-13, Renming Nanlu, Chengdu 610041, P. R. China ; Key Laboratory of Development and Application of Rural Renewable Energy, Ministry of Agriculture, Chengdu 610041, P. R. China.
authors.forename: Ming Xiong
authors.initials: MX
authors.lastname: He
authors.affiliation: Biogas Institute of Ministry of Agriculture, Biomass Energy Technology Research Centre, Section 4-13, Renming Nanlu, Chengdu 610041, P. R. China.
authors.forename: Bo
authors.initials: B
authors.lastname: Wu
authors.affiliation: Biogas Institute of Ministry of Agriculture, Biomass Energy Technology Research Centre, Section 4-13, Renming Nanlu, Chengdu 610041, P. R. China.
authors.forename: Han
authors.initials: H
authors.lastname: Qin
authors.affiliation: Institute of Agricultural Resources and Regional Planning, Chinese Academy of Agricultural Sciences, Beijing 100081, P. R. China.
authors.forename: Zhi Yong
authors.initials: ZY
authors.lastname: Ruan
authors.affiliation: Biogas Institute of Ministry of Agriculture, Biomass Energy Technology Research Centre, Section 4-13, Renming Nanlu, Chengdu 610041, P. R. China.
authors.forename: Fu Rong
authors.initials: FR
authors.lastname: Tan
authors.affiliation: Biogas Institute of Ministry of Agriculture, Biomass Energy Technology Research Centre, Section 4-13, Renming Nanlu, Chengdu 610041, P. R. China.
authors.forename: Jing Li
authors.initials: JL
authors.lastname: Wang
authors.affiliation: Biogas Institute of Ministry of Agriculture, Biomass Energy Technology Research Centre, Section 4-13, Renming Nanlu, Chengdu 610041, P. R. China.
authors.forename: Zong Xia
authors.initials: ZX
authors.lastname: Shui
authors.affiliation: Biogas Institute of Ministry of Agriculture, Biomass Energy Technology Research Centre, Section 4-13, Renming Nanlu, Chengdu 610041, P. R. China.
authors.forename: Li Chun
authors.initials: LC
authors.lastname: Dai
authors.affiliation: Biogas Institute of Ministry of Agriculture, Biomass Energy Technology Research Centre, Section 4-13, Renming Nanlu, Chengdu 610041, P. R. China.
authors.forename: Qi Li
authors.initials: QL
authors.lastname: Zhu
authors.affiliation: Biogas Institute of Ministry of Agriculture, Biomass Energy Technology Research Centre, Section 4-13, Renming Nanlu, Chengdu 610041, P. R. China.
authors.forename: Ke
authors.initials: K
authors.lastname: Pan
authors.affiliation: Biogas Institute of Ministry of Agriculture, Biomass Energy Technology Research Centre, Section 4-13, Renming Nanlu, Chengdu 610041, P. R. China.
authors.forename: Xiao Yu
authors.initials: XY
authors.lastname: Tang
authors.affiliation: Biogas Institute of Ministry of Agriculture, Biomass Energy Technology Research Centre, Section 4-13, Renming Nanlu, Chengdu 610041, P. R. China.
authors.forename: Wen Guo
authors.initials: WG
authors.lastname: Wang
authors.affiliation: Biogas Institute of Ministry of Agriculture, Biomass Energy Technology Research Centre, Section 4-13, Renming Nanlu, Chengdu 610041, P. R. China ; Key Laboratory of Development and Application of Rural Renewable Energy, Ministry of Agriculture, Chengdu 610041, P. R. China.
authors.forename: Qi Chun
authors.initials: QC
authors.lastname: Hu
keywords: Zymomonas mobilis; biofuel; biorefinery; building block chemical; platform