title: Sulfur as a signaling nutrient through hydrogen sulfide.
abstract: Hydrogen sulfide (H₂S) has emerged as an important signaling molecule with beneficial effects on various cellular processes affecting, for example, cardiovascular and neurological functions. The physiological importance of H₂S is motivating efforts to develop strategies for modulating its levels. However, advancement in the field of H₂S-based therapeutics is hampered by fundamental gaps in our knowledge of how H₂S is regulated, its mechanism of action, and its molecular targets. This review provides an overview of sulfur metabolism; describes recent progress that has shed light on the mechanism of H₂S as a signaling molecule; and examines nutritional regulation of sulfur metabolism, which pertains to health and disease.
authors.affiliation: Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109-0600; email: rbanerje@umich.edu.
authors.forename: Omer
authors.initials: O
authors.lastname: Kabil
authors.forename: Victor
authors.initials: V
authors.lastname: Vitvitsky
authors.forename: Ruma
authors.initials: R
authors.lastname: Banerjee
mesh_terms: D000375:Aging / Q000378:metabolism; D000603:Amino Acids, Sulfur / Q000378:metabolism; D000818:Animals; D002319:Cardiovascular System / Q000201:enzymology / Q000378:metabolism; D002490:Central Nervous System / Q000098:blood supply / Q000201:enzymology / Q000378:metabolism; D004032:Diet; D059865:Endoplasmic Reticulum Stress; D004730:Endothelium, Vascular / Q000201:enzymology / Q000378:metabolism*; D006801:Humans; D006862:Hydrogen Sulfide / Q000378:metabolism*; D008954:Models, Biological; D009751:Nutritional Requirements; D015398:Signal Transduction; D013455:Sulfur / Q000378:metabolism*; D013457:Sulfur Compounds / Q000378:metabolism*
chemical_list: D000603:Amino Acids, Sulfur; D013457:Sulfur Compounds; D013455:Sulfur; D006862:Hydrogen Sulfide
keywords: hydrogen sulfide; nutrition; signaling; sulfide oxidation; sulfur metabolism