title: Host modulation therapy: An indispensable part of perioceutics.
abstract: Traditionally, only antimicrobials have been used as the chemotherapeutic modality for the treatment of periodontitis. Though bacteria are the primary etiologic factors of periodontal diseases, yet the extent and severity of tissue destruction seen in periodontitis is determined by the host immuno-inflammatory response to these bacteria. This increasing awareness and knowledge of the host-microbial interaction in periodontal pathogenesis has presented the opportunity for exploring new therapeutic strategies for periodontitis by means of targeting host response via host-modulating agents. This has lead to the emergence of the field of "Perioceutics" i.e. the use of parmacotherapeutic agents including antimicrobial therapy as well as host modulatory therapy for the management of periodontitis. These host-modulating agents used as an adjunct tip the balance between periodontal health and disease progression in the direction of a healing response. In this article the host-modulating role of various systemically and locally delivered perioceutic agents will be reviewed.
authors.affiliation: Department of Periodontics, Babu Banarasi Das College of Dental Sciences, Babu Banarasi Das University, Lucknow, India.
authors.forename: Minkle
authors.initials: M
authors.lastname: Gulati
authors.affiliation: Department of Periodontics, Chhatrapati Shahuji Maharaj Medical University, Lucknow, India.
authors.forename: Vishal
authors.initials: V
authors.lastname: Anand
authors.affiliation: Department of Periodontics, Babu Banarasi Das College of Dental Sciences, Babu Banarasi Das University, Lucknow, India.
authors.forename: Vivek
authors.initials: V
authors.lastname: Govila
authors.affiliation: Department of Oral and Maxillofacial Surgery, Vinayaka Missions Sankarachariyar Dental College, Salem, Tamil Nadu, India.
authors.forename: Nikil
authors.initials: N
authors.lastname: Jain
keywords: Bisphosphonate; host modulation; locally delivered; nonsteroidal anti-inflammatory drugs; perioceutics; periodontitis; systemically delivered; tetracycline