title: NCOA5, a molecular link between type 2 diabetes and liver cancer.
abstract: It is reported that nuclear receptor co-activator 5 (NCOA5) is a possible susceptibility gene to both type 2 diabetes (T2D) and hepatocellular carcinoma (HCC). The link between these two diseases is an important area of study with the growing prevalence of T2D. Thus, discovery of a genetic link may have great impact on the field. The group used NCOA5 (+/-) mice to observe the effects of the gene's haploinsufficiency on the symptoms of T2D and HCC and claimed NCOA5's regulation of IL-6 in the pathogenesis of the diseases.
authors.affiliation: Biomedical Sciences Graduate Program, Department of Pathology, and Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093-0864, USA.
authors.forename: Connie Y
authors.initials: CY
authors.lastname: Liu
authors.affiliation: Biomedical Sciences Graduate Program, Department of Pathology, and Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093-0864, USA.
authors.forename: Gen-Sheng
authors.initials: GS
authors.lastname: Feng
keywords: Nuclear receptor co-activator 5 (NCOA5); hepatocarcinoma; type 2 dibetes (T2D)