title: Arylation and heteroarylation of thienylsulfonamides with organotrifluoroborates.
abstract: A mild, practical protocol has been developed for the Suzuki cross-coupling of unprotected thienylsulfonamides from air- and bench-stable organotrifluoroborates in the absence of a protecting group on the sulfonamide nitrogen. The developed synthetic method can be applied to the preparation of various arylated and heteroarylated thienylsulfonamides under conditions that are tolerant of a broad range of functional groups.
authors.affiliation: Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania , 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.
authors.forename: Mnaza
authors.initials: M
authors.lastname: Noreen
authors.forename: Nasir
authors.initials: N
authors.lastname: Rasool
authors.forename: Mirna
authors.initials: M
authors.lastname: El Khatib
authors.forename: Gary A
authors.initials: GA
authors.lastname: Molander
mesh_terms: D001881:Borates / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry*; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D001881:Borates; D006571:Heterocyclic Compounds; D013449:Sulfonamides; D013876:Thiophenes; D009584:Nitrogen