title: Facile preparation of mussel-inspired polyurethane hydrogel and its rapid curing behavior.
abstract: A facile method was found to incorporate a mussel-inspired adhesive moiety into synthetic polymers, and mussel mimetic polyurethanes were developed as adhesive hydrogels. In these polymers, a urethane backbone was substituted for the polyamide chain of mussel adhesive proteins, and dopamine was appended to mimic the adhesive moiety of adhesive proteins. A series of mussel mimetic polyurethanes were created through a step-growth polymerization based on hexamethylene diisocyanate as a hard segment, PEG having different molecular weights as a soft segment, and lysine-dopamine as a chain extender. Upon a treatment with Fe(3+), the aqueous mussel mimetic polyurethane solutions can be triggered by pH adjustment to form adhesive hydrogels instantaneously; these materials can be used as injectable adhesive hydrogels. Upon a treatment with NaIO4, the mussel mimetic polyurethane solutions can be cured in a controllable period of time. The successful combination of the unique mussel-inspired adhesive moiety with a tunable polyurethane structure can result in a new kind of mussel-inspired adhesive polymers.
authors.affiliation: School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites (Shanghai Jiao Tong University), Shanghai Jiao Tong University , Shanghai 200240, China.
authors.forename: Peiyu
authors.initials: P
authors.lastname: Sun
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Xiong
authors.initials: X
authors.lastname: Yao
authors.forename: Ying
authors.initials: Y
authors.lastname: Peng
authors.forename: Xiaoxiong
authors.initials: X
authors.lastname: Tu
authors.forename: Pengfei
authors.initials: P
authors.lastname: Du
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zheng
authors.forename: Xinling
authors.initials: X
authors.lastname: Wang
mesh_terms: D000818:Animals; D032701:Biomimetics / Q000379:methods*; D049872:Bivalvia / Q000737:chemistry*; D002396:Catechols / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000737:chemistry; D004298:Dopamine / Q000737:chemistry; D004952:Esters / Q000737:chemistry; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000138:chemical synthesis* / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007452:Iodates / Q000737:chemistry; D007501:Iron / Q000737:chemistry; D008024:Ligands; D008239:Lysine / Q000737:chemistry; D008970:Molecular Weight; D010084:Oxidation-Reduction; D011140:Polyurethanes / Q000138:chemical synthesis* / Q000737:chemistry*; D066244:Proton Magnetic Resonance Spectroscopy; D012212:Rheology; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry; D013997:Time Factors
chemical_list: D002396:Catechols; D003432:Cross-Linking Reagents; D004952:Esters; D007452:Iodates; D008024:Ligands; D011140:Polyurethanes; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D007501:Iron; D008239:Lysine; C034221:catechol; C032285:sodium iodate; D004298:Dopamine