title: UV and melanoma: the TP53 link.
abstract: Ultraviolet radiation (UVR) is a major risk factor for melanoma development, but it has been unclear exactly how UVR leads to melanomagenesis. In a recent publication in Nature, Viros et al. identify TP53/Trp53 as a UVR-target gene in melanoma and show that UVR-induced TP53/Trp53 mutations accelerate BRAF(V600E)-driven melanomagenesis.
authors.affiliation: Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.
authors.forename: Yeon Sook
authors.initials: YS
authors.lastname: Choi
authors.affiliation: Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.
authors.forename: David E
authors.initials: DE
authors.lastname: Fisher
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000528:radiation effects*; D005260:Female; D006801:Humans; D008545:Melanoma / Q000235:genetics* / Q000473:pathology*; D016296:Mutagenesis / Q000528:radiation effects*; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D016159:Tumor Suppressor Protein p53; D048493:Proto-Oncogene Proteins B-raf