title: Water solubilization capacity of pharmaceutical microemulsions based on Peceol®, lecithin and ethanol.
abstract: Biocompatible microemulsions composed of Peceol(®), lecithin, ethanol and water developed for encapsulation of hydrophilic drugs were investigated. The binary mixture Peceol(®)/ethanol was studied first. It was shown that the addition of ethanol to pure Peceol(®) has a significant fluidifying and disordering effect on the Peceol(®) supramolecular structure with an enhancement in water solubilization. The water solubilization capacity was improved by adding lecithin as a third component. It was then demonstrated that the ethanol/lecithin weight ratio played an important role in determining the optimal composition in term of water solubilization efficiency, a necessary property for a nutraceutical or pharmaceutical application. The optimal ethanol/lecithin weight ratio in the Peceol(®) rich region was found to be 40/60. Combination different techniques such as SAXS, fluorimetry, rheology and conductivity, we analyzed the water uptake within the microemulsion taking into account the partitioning of ethanol between polar and apolar domains. This ethanol distribution quantified along a water dilution line has a major effect on microemulsion properties.
authors.affiliation: Institut Charles Gerhardt Montpellier, UMR 5253 CNRS-ENSCM-UM2-UM1, Equipe MACS, 8 rue de l'Ecole Normale, 34296 Montpellier, France; Medesis Pharma, Avenue du Golf, L'Orée des Mas, Les Cyprès, 34670 Baillargues, France.
authors.forename: Abdelkader
authors.initials: A
authors.lastname: Mouri
authors.affiliation: Institut de Chimie Séparative de Marcoule, ICSM UMR 5257 (CEA/CNRS/UM2/ENSCM), 30206 Bagnols sur Cèze, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Diat
authors.affiliation: Institut Charles Gerhardt Montpellier, UMR 5253 CNRS-ENSCM-UM2-UM1, Equipe MACS, 8 rue de l'Ecole Normale, 34296 Montpellier, France.
authors.forename: Dan Alain
authors.initials: DA
authors.lastname: Lerner
authors.affiliation: Institut des Biomolécules Max Mousseron, UMR CNRS 5247, Université de Montpellier I, 34060 Montpellier, France.
authors.forename: Abdeslam
authors.initials: A
authors.lastname: El Ghzaoui
authors.affiliation: Institut Charles Gerhardt Montpellier, UMR 5253 CNRS-ENSCM-UM2-UM1, Equipe MACS, 8 rue de l'Ecole Normale, 34296 Montpellier, France.
authors.forename: Alessia
authors.initials: A
authors.lastname: Ajovalasit
authors.affiliation: Institut Charles Gerhardt Montpellier, UMR 5253 CNRS-ENSCM-UM2-UM1, Equipe MACS, 8 rue de l'Ecole Normale, 34296 Montpellier, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Dorandeu
authors.affiliation: Medesis Pharma, Avenue du Golf, L'Orée des Mas, Les Cyprès, 34670 Baillargues, France.
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Maurel
authors.affiliation: Institut Charles Gerhardt Montpellier, UMR 5253 CNRS-ENSCM-UM2-UM1, Equipe MACS, 8 rue de l'Ecole Normale, 34296 Montpellier, France.
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Devoisselle
authors.affiliation: Institut Charles Gerhardt Montpellier, UMR 5253 CNRS-ENSCM-UM2-UM1, Equipe MACS, 8 rue de l'Ecole Normale, 34296 Montpellier, France. Electronic address: philippe.legrand@enscm.fr.
authors.forename: Philippe
authors.initials: P
authors.lastname: Legrand
mesh_terms: D004655:Emulsions / Q000737:chemistry*; D000431:Ethanol / Q000737:chemistry*; D054709:Lecithins / Q000737:chemistry*; D009829:Oleic Acids / Q000737:chemistry*; D012212:Rheology; D012995:Solubility; D014867:Water / Q000737:chemistry*
chemical_list: D004655:Emulsions; D054709:Lecithins; D009829:Oleic Acids; C482692:Peceol; D014867:Water; D000431:Ethanol
keywords: Ethanol partitioning; Microemulsion; Peceol(®); Phase diagram; Water solubilization capacity