title: Therapeutic dose of acetaminophen as a possible risk factor for acute kidney injury: learning from two healthy young adult cases.
abstract: Acetaminophen overdose can lead to severe liver and kidney failure; however, the risk of therapeutic doses in healthy individuals causing acute kidney injury (AKI) is less clear. We herein describe the cases of two young adults with renal biopsy-proven acute tubular necrosis under a therapeutic dose of acetaminophen. The first patient exhibited mild reversible renal insufficiency, whereas, in the second case, the patient demonstrated a slightly increased serum creatinine level and enlarged kidneys and the administration of contrast media and antibiotics may have worsened the renal dysfunction, leading to the need for temporal hemodialysis. Physicians should be aware of the risk of acetaminophen causing AKI and avoid administering other nephrotoxic agents in such cases.
authors.affiliation: Department of Internal Medicine, Teikyo University School of Medicine, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Kato
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Fujigaki
authors.forename: Reiko
authors.initials: R
authors.lastname: Inoue
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Asakawa
authors.forename: Shoko
authors.initials: S
authors.lastname: Shin
authors.forename: Tomoko
authors.initials: T
authors.lastname: Shima
authors.forename: Junko
authors.initials: J
authors.lastname: Furunishi
authors.forename: Masato
authors.initials: M
authors.lastname: Higaki
authors.forename: Masayuki
authors.initials: M
authors.lastname: Tanemoto
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: Kazufusa
authors.initials: K
authors.lastname: Hoshimoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Uozaki
authors.forename: Shunya
authors.initials: S
authors.lastname: Uchida
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000506:poisoning*; D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000175:diagnosis; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000506:poisoning; D001706:Biopsy; D004305:Dose-Response Relationship, Drug; D062787:Drug Overdose / Q000150:complications*; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology; D010784:Photomicrography; D012307:Risk Factors; D055815:Young Adult
chemical_list: D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen