title: Polycyclic aromatic hydrocarbon (PAH) exposure and oxidative stress for a rural population from the North China Plain.
abstract: Polycyclic aromatic hydrocarbons (PAHs) belong to a class of ubiquitous pollutants and are possibly associated with adverse health effects. In this study, we aimed to assess PAH exposure by measuring the hydroxylated metabolites (hydroxy-PAHs) in urine samples of a rural population from the North China Plain and to explore the possible associations between PAH exposure and oxidative stress indicated by urinary malondialdehyde (MDA) and 8-hydroxy-2′-deoxyguanosine (8-OHdG). High levels of urinary hydroxy-PAHs were observed, with the geometric mean concentrations of 0.57, 2.2, 5.0, 7.0, and 16.6 μg g−1 creatinine for 1-hydroxypyrene, hydroxyphenanthrenes, hydroxyfluorenes, hydroxybiphenyls, and hydroxynaphthalenes, respectively. Particularly in the winter season, the exposures were 2.3–6.0-fold of those in the spring. Corresponding to PAH exposure, levels of urinary MDA were positively associated with hydroxy-PAHs after controlling for confounders in the linear regression models (p < 0.05). An estimation indicated 21.3–39.3 % increment of urinary MDA per one-fold increase of hydroxy-PAHs. In contrast, no significant correlation was found between urinary 8-OHdG and hydroxy-PAHs; alternatively, living at the e-waste recycling site was found a significant factor on this oxidative DNA damage. These results provide evidence on high PAH exposure and the induction of oxidative stress on lipid peroxidation for this rural population.
authors.forename: Qiaoyun
authors.initials: Q
authors.lastname: Yang
authors.forename: Xinghua
authors.initials: X
authors.lastname: Qiu
authors.forename: Ran
authors.initials: R
authors.lastname: Li
authors.forename: Jin
authors.initials: J
authors.lastname: Ma
authors.forename: Keqiu
authors.initials: K
authors.lastname: Li
authors.forename: Guang
authors.initials: G
authors.lastname: Li
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D002681:China; D004249:DNA Damage; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine; D004781:Environmental Exposure / Q000032:analysis*; D004785:Environmental Pollutants / Q000652:urine*; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000652:urine; D008875:Middle Aged; D018384:Oxidative Stress; D011084:Polycyclic Aromatic Hydrocarbons / Q000652:urine*; D012424:Rural Population
chemical_list: D004785:Environmental Pollutants; D011084:Polycyclic Aromatic Hydrocarbons; D008315:Malondialdehyde; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine