title: Diagnostic challenges in cornual epithelioid trophoblastic tumor.
abstract: OBJECTIVE
  We present a case of primary cornual epithelioid trophoblastic tumor (ETT) because of its rarity and diagnostic and therapeutic challenge.
  
  
  METHODS
  A 28-year-old woman, gravida 1, para 1, who missed menstruation for 3 months, had an elevated β-human chorionic gonadotropin serum level of 2764 mIU/mL, an absence of intrauterine pregnancy, and the presence of an adnexal mass detected by transvaginal ultrasound. As an ectopic pregnancy was suspected, laparoscopic surgery was performed and showed a right corneal mass. Complete excision of the tumor was done through exploratory laparotomy. Frozen pathology favored the diagnosis of squamous cell carcinoma. Since there was no apparent tumor at other sites, no additional surgery was done. The final pathology showed ETT. Primary ETT is often misdiagnosed as an ectopic pregnancy, leading to delayed treatment, and poses a diagnostic challenge in distinguishing it from squamous cell carcinoma during pathological examination.
  
  
  CONCLUSIONS
  Careful evaluation and avoidance of overtreatment are emphasized.
authors.affiliation: Division of Gynecology, Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, National Yang-Ming University, School of Medicine, Taipei, Taiwan.
authors.forename: Feng-Ying
authors.initials: FY
authors.lastname: Fang
authors.affiliation: Department of Pathology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Pathology, National Yang-Ming University, School of Medicine, Taipei, Taiwan.
authors.forename: Chiung-Ru
authors.initials: CR
authors.lastname: Lai
authors.affiliation: Division of Gynecology, Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, National Yang-Ming University, School of Medicine, Taipei, Taiwan.
authors.forename: Ming-Jie
authors.initials: MJ
authors.lastname: Yang
authors.affiliation: Department of Obstetrics and Gynecology, National Yang-Ming University, School of Medicine, Taipei, Taiwan; Department of Obstetrics and Gynecology, National Yang-Ming University Hospital, Ilan, Taiwan.
authors.forename: Beng-Shian
authors.initials: BS
authors.lastname: Huang
authors.affiliation: Division of Gynecology, Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, National Yang-Ming University, School of Medicine, Taipei, Taiwan.
authors.forename: Chih-Yao
authors.initials: CY
authors.lastname: Chen
authors.affiliation: Department of Obstetrics and Gynecology, Kuo General Hospital, Tainan, Taiwan.
authors.forename: Yiu-Tai
authors.initials: YT
authors.lastname: Li
authors.affiliation: Division of Gynecology, Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, National Yang-Ming University, School of Medicine, Taipei, Taiwan.
authors.forename: Ming-Shyen
authors.initials: MS
authors.lastname: Yen
authors.affiliation: Division of Gynecology, Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, National Yang-Ming University, School of Medicine, Taipei, Taiwan; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan. Electronic address: phwang@vghtpe.gov.tw.
authors.forename: Peng-Hui Peter
authors.initials: PH
authors.lastname: Wang
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000175:diagnosis*; D014328:Trophoblastic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D014463:Ultrasonography; D014594:Uterine Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery
keywords: epithelioid trophoblastic tumor; gestational trophoblastic neoplasm; immunohistochemistry