title: Novel starch based nano scale enteric coatings from soybean meal for colon-specific delivery.
abstract: Soybean meal was used to isolate resistant starch and produce nanoparticles, which could be potential coating materials for colonic nutrient and drug deliveries. The nanoparticles were in 40 ± 33.2 nm ranges. These nanoparticles were stable under simulated human physiological conditions. The degrees of dissolution in both stomach and intestinal conditions were less than 30%. Furthermore, the nanoparticles were less susceptible to pancreatic enzymatic digestion (20%), which was also evidenced by the co-existence of B-type crystalline pattern. In addition to the dissolution and digestion studies in the upper gastrointestinal tract, the nanoparticles were subjected to in vitro fermentation by Bifidobacterium brevis and Lactobacillus casei. Both species showed an increase in growth and activity, while producing short chain fatty acids: acetate, propionate, and butyrates in varying amounts. Overall this study clearly demonstrated a novel method that can be used for colon-specific delivery of bioactive compounds such as drugs and nutrients.
authors.affiliation: School of Food Systems, North Dakota State University, IACC 372, 1320 Albrecht Blvd, Dept. 7640, PO Box 6050, Fargo, ND 58108-6050, USA.
authors.forename: Nilushni
authors.initials: N
authors.lastname: Sivapragasam
authors.affiliation: School of Food Systems, North Dakota State University, IACC 372, 1320 Albrecht Blvd, Dept. 7640, PO Box 6050, Fargo, ND 58108-6050, USA. Electronic address: pushparajah.thavaraj@ndsu.edu.
authors.forename: Pushparajah
authors.initials: P
authors.lastname: Thavarajah
authors.affiliation: USDA-ARS Cereal Crops Research Unit, Hard Spring and Durum Wheat Quality Laboratory, Dept. 7640, 214 Harris Hall, P.O. Box 6050, Fargo, ND 58108-6050, USA.
authors.forename: Jae-Bom
authors.initials: JB
authors.lastname: Ohm
authors.affiliation: USDA-ARS Cereal Crops Research Unit, Hard Spring and Durum Wheat Quality Laboratory, Dept. 7640, 214 Harris Hall, P.O. Box 6050, Fargo, ND 58108-6050, USA.
authors.forename: Jae-Bom
authors.initials: JB
authors.lastname: Ohm
authors.affiliation: Veterinary and Microbiological Sciences, North Dakota State University, Van Es 118, Fargo, ND 58108-6050, USA.
authors.forename: Khaitsa
authors.initials: K
authors.lastname: Margaret
authors.affiliation: School of Food Systems, North Dakota State University, Dept. 7640, 208 Harris Hall, P.O. Box 6050, Fargo, ND 58108-6050, USA.
authors.forename: Dil
authors.initials: D
authors.lastname: Thavarajah
mesh_terms: D001644:Bifidobacterium / Q000201:enzymology; D003106:Colon / Q000201:enzymology*; D016503:Drug Delivery Systems; D005232:Fatty Acids, Volatile / Q000096:biosynthesis; D006801:Humans; D007780:Lacticaseibacillus casei / Q000201:enzymology; D008954:Models, Biological; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*; D013025:Glycine max / Q000737:chemistry*; D013213:Starch / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*; D013270:Stomach / Q000201:enzymology
chemical_list: D005232:Fatty Acids, Volatile; D013213:Starch
keywords: Colon-specific delivery; In vitro fermentation; Nanoparticles; Resistant starch; Soybean meal