title: Supplementation of Vitis thunbergii root extract alleviated high-fat diet-induced obesity in C57BL/6J mice.
abstract: Vitis thunbergii root, widely used as folk medicine in Taiwan, has been found to contain polyphenolic compounds and resveratrol derivatives, which have been implicated in the prevention and treatment of obesity. Thus, we hypothesized it might show beneficial effects against obesity. C57BL/6JNarl mice fed with a high fat diet for 14 weeks increased body weight and epididymal fat pad weight, and accompanied by fatty liver, hyperglycemia, hyperinsulinemia, insulin resistance, hyperleptinemia, hypercholesterolemia, hyper-LDL-cholesterol, and high level of serum GPT, GOT, creatinine, and BUN. Supplementation of VTE in the last 7 weeks remarkably decreased body weight and epididymal fat pad weight, implying a potential anti-obesity effect. Mechanistic study showed that VTE supplementation increased energy expenditure-related CPT1 mRNA expression and AMPK phosphorylation, and decreased lipogenesis-related SREBP-1 expression in liver. In conclusion, Vitis thunbergii roots could alleviate high fat diet-induced obesity and its related complications by enhancing hepatic fatty acid oxidation and inhibitng lipogenesis.
authors.affiliation: a Department of Veterinary Medicine , National Chung Hsing University , Taichung , Taiwan.
authors.forename: Hong-Ming
authors.initials: HM
authors.lastname: Hsu
authors.forename: Wen-Ying
authors.initials: WY
authors.lastname: Chen
authors.forename: Tzer-Kuan
authors.initials: TK
authors.lastname: Hu
authors.forename: Frank Chiahung
authors.initials: FC
authors.lastname: Mao
mesh_terms: D017667:Adipocytes / Q000187:drug effects / Q000473:pathology; D000273:Adipose Tissue / Q000187:drug effects / Q000473:pathology; D000818:Animals; D001774:Blood Chemical Analysis; D001835:Body Weight / Q000187:drug effects; D059305:Diet, High-Fat / Q000009:adverse effects*; D019587:Dietary Supplements / Q000032:analysis*; D004435:Eating / Q000187:drug effects; D000431:Ethanol / Q000737:chemistry; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000139:chemically induced* / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots / Q000737:chemistry*; D027843:Vitis / Q000737:chemistry*
chemical_list: D010936:Plant Extracts; D000431:Ethanol
keywords: Vitis thunbergii; mouse; obesity