title: Studies on assessment methods of malignant ascites residue and changes of verapamil concentration in intraperitoneal perfusion chemotherapy.
abstract: OBJECTIVE
  To establish a simple method for estimating residual peritoneal ascites in order to determine the optimum verapamil (VRP) initial concentration in the intraperitoneal perfusion chemotherapy.
  
  
  METHODS
  (1) Pelvic size of adults was assessed by measuring distance from the superior margin of pubic symphysis to the connecting line of two anterior superior spine (SL) and to the midpoint of the line (SM) in 172 adults; (2) 35 postoperative gastric or colon cancer patients with indications for use of preventive intraperitoneal chemotherapy were infused with 1,000-1,250 mL 0.9 % normal saline solution for about 15 min and used for perfusate detection by moving along the midpoint of connecting line of two anterior superior spine after 5 min of infusion; (3) The VRP concentration in ascites was detected by liquid chromatography.
  
  
  RESULTS
  The distance between two anterior superior spines for adult were 29.6 ± 2.6 cm and the distance from the superior margin of pubic symphysis to the midpoint between two anterior superior spines was 10.6 ± 1.9 cm. When the total intraperitoneal infusion fluid was 1,000-1,250 mL, it could be detected by B-mode ultrasonic device at 0.1-0.3 cm directly below the midpoint of two anterior superior spines. The VRP reversal concentration of drug resistance could maintain for 90 min when the residual ascites volume was within the range of 1,000-1,250 mL.
  
  
  CONCLUSIONS
  Detection of liquid at the position directly below or above the midpoint of two anterior superior spines by B-mode ultrasonic device in patients in erect position could be a simple method for estimation of ascites volume (liquid found at 0.1-0.3 cm directly below the midpoint of two anterior superior spines suggested that ascites volume was smaller than 1,000-1,250 mL). The method could be used for determination of VRP initial concentration for IPC treatment.
authors.affiliation: Department of Medical Oncology, Anhui Provincial Cancer Hospital, Anhui Medical University, 107 Huanhu Road East, Hefei, 230031, People's Republic of China.
authors.forename: Chengtao
authors.initials: C
authors.lastname: Wen
authors.forename: Qiaohong
authors.initials: Q
authors.lastname: Duan
authors.forename: Tengyue
authors.initials: T
authors.lastname: Zhang
authors.forename: Yabei
authors.initials: Y
authors.lastname: Liu
authors.forename: Yang
authors.initials: Y
authors.lastname: Wu
authors.forename: Kelong
authors.initials: K
authors.lastname: Ma
authors.forename: Pingsheng
authors.initials: P
authors.lastname: Fan
authors.forename: Weidong
authors.initials: W
authors.lastname: Jia
mesh_terms: D000368:Aged; D001201:Ascites / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D002853:Chromatography, Liquid; D003110:Colonic Neoplasms / Q000150:complications / Q000601:surgery; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D010388:Pelvis / Q000033:anatomy & histology / Q000000981:diagnostic imaging; D010532:Peritoneal Diseases / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D012016:Reference Values; D013131:Spine / Q000000981:diagnostic imaging; D013274:Stomach Neoplasms / Q000150:complications / Q000601:surgery; D016683:Supine Position; D014463:Ultrasonography; D014700:Verapamil / Q000008:administration & dosage* / Q000032:analysis*
chemical_list: D014700:Verapamil