title: Treating breast cancer radiotherapy-induced moist desquamation with a traditional Chinese medicine formula: a case series pilot study.
abstract: Abstract Objective: A case series is presented to investigate the efficacy and safety of Erhegao for patients with breast cancer who have radiotherapy-induced moist desquamation.
  
  
  METHODS
  Eighteen women with breast cancer who received radiotherapy and developed moist desquamation were enrolled. Erhegao cream, a Traditional Chinese Medicine formula consisting of zinc oxide powder, calamine powder, and lithospermum oil, was applied on areas of moist desquamation. Application was repeated once a day until healing. The primary end point for efficacy was the time to healing of the moist desquamation areas. A numerical rating scale was used to measure wound pain relief daily. Incidence of toxicity was also assessed.
  
  
  RESULTS
  The average time to healing of the moist desquamation area was 13.56 days. The mean pain scores on the first, third, and seventh days were 5.22, 2.94, and 0.83, respectively. Eight-three percent of patients reported pain relief after the first 3 days, and 94%, after the first week. The mean daily reduction in the pain score was 0.40. None of the patients developed clinical infections or reported any toxicity.
  
  
  CONCLUSIONS
  This formula is effective and safe, especially for pain relief, and may be an alternative treatment for radiotherapy-induced moist desquamation in patients with breast cancer. Future randomized, controlled studies are needed to better evaluate the efficacy of Erhegao cream.
authors.affiliation: 1 Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University , Chengdu, China .
authors.forename: Wang
authors.initials: W
authors.lastname: Xiaoshan
authors.forename: Li
authors.initials: L
authors.lastname: Zhixi
authors.forename: Liang
authors.initials: L
authors.lastname: Liang
authors.forename: Luo
authors.initials: L
authors.lastname: Shuchun
authors.forename: Wang
authors.initials: W
authors.lastname: Xia
authors.forename: Wang
authors.initials: W
authors.lastname: Yuyi
authors.forename: Luo
authors.initials: L
authors.lastname: Feng
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000532:radiotherapy*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D029684:Lithospermum; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy*; D010147:Pain Measurement; D010865:Pilot Projects; D010938:Plant Oils / Q000494:pharmacology / Q000627:therapeutic use; D011832:Radiation Injuries / Q000188:drug therapy* / Q000209:etiology; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D063465:Skin Cream; D012871:Skin Diseases / Q000188:drug therapy* / Q000209:etiology; D014945:Wound Healing / Q000187:drug effects*; D015034:Zinc Oxide / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D004365:Drugs, Chinese Herbal; D010938:Plant Oils; D015034:Zinc Oxide