title: Metabolic asymmetry in cancer: a "balancing act" that promotes tumor growth.
abstract: Profound metabolic differences between cancer cells and fibroblasts promote tumorigenesis. A study by Valencia and colleagues in this issue of Cancer Cell supports this assertion. They observed that metabolic asymmetry in prostate tumors drives aggressive disease with high p62 in anabolic cancer cells, but loss of p62 in catabolic fibroblasts.
authors.affiliation: Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.
authors.forename: Ubaldo E
authors.initials: UE
authors.lastname: Martinez-Outschoorn
authors.affiliation: Breakthrough Breast Cancer Research Unit, Institute of Cancer Sciences, University of Manchester, Manchester M13 9PL, UK; Manchester Centre for Cellular Metabolism (MCCM), Institute of Cancer Sciences, University of Manchester, Manchester M13 9PL, UK. Electronic address: fsotgia@gmail.com.
authors.forename: Federica
authors.initials: F
authors.lastname: Sotgia
authors.affiliation: Breakthrough Breast Cancer Research Unit, Institute of Cancer Sciences, University of Manchester, Manchester M13 9PL, UK; Manchester Centre for Cellular Metabolism (MCCM), Institute of Cancer Sciences, University of Manchester, Manchester M13 9PL, UK. Electronic address: michaelp.lisanti@gmail.com.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Lisanti
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D004734:Energy Metabolism; D005347:Fibroblasts / Q000201:enzymology*; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000201:enzymology*; D008297:Male; D000076222:Mechanistic Target of Rapamycin Complex 1; D046912:Multiprotein Complexes / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000201:enzymology*; D000071456:Sequestosome-1 Protein; D015398:Signal Transduction; D017154:Stromal Cells / Q000201:enzymology*; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D006360:Heat-Shock Proteins; D046912:Multiprotein Complexes; C099718:SQSTM1 protein, human; D000071456:Sequestosome-1 Protein; C101343:Sqstm1 protein, mouse; D000076222:Mechanistic Target of Rapamycin Complex 1; D058570:TOR Serine-Threonine Kinases