title: Chemical composition and anti-inflammation activity of essential oils from Citrus unshiu flower.
abstract: Though many essential oils from citrus peels are claimed to have several medicinal functions, the chemical composition and biological activities of the essential oils of Citrus flowers have not been well described. Therefore, this study intended to investigate the chemical composition and anti-inflammatory potential of essential oils from C. unshiu flower (CEO) to support its purported beneficial health effects. The chemical constituents of the CEO, analyzed by gas chromatography-mass spectrometry (GC-MS), included y-terpinene (24.7%), 2-beta-pinene (16.6%), 1-methyl-2-isopropylbenzene (11.5%), L-limonene (5.7%), beta3-ocimene (5.6%), and alpha-pinene (4.7%). The effects of the CEO on nitric oxide (NO) and prostaglandin E2 (PGE2) production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages were also examined. The results indicate that the CEO is an effective inhibitor of LPS-induced NO and PGE2 production in RAW 264.7 cells. Additionally, CEO was shown to suppress the production of inflammatory cytokines including interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha, and IL-6. Based on these results, CEO may be considered a potential anti-inflammatory candidate with human health benefits.
authors.forename: Min-Jin
authors.initials: MJ
authors.lastname: Kim
authors.forename: Kyong-Wol
authors.initials: KW
authors.lastname: Yang
authors.forename: Sang Suk
authors.initials: SS
authors.lastname: Kim
authors.forename: Suk Man
authors.initials: SM
authors.lastname: Park
authors.forename: Kyung Jin
authors.initials: KJ
authors.lastname: Park
authors.forename: Kwang Sik
authors.initials: KS
authors.lastname: Kim
authors.forename: Young Hun
authors.initials: YH
authors.lastname: Choi
authors.forename: Kwang Keun
authors.initials: KK
authors.lastname: Cho
authors.forename: Chang-Gu
authors.initials: CG
authors.lastname: Hyun
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D002957:Citrus / Q000737:chemistry*; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D015232:Dinoprostone / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D035264:Flowers / Q000737:chemistry; D051379:Mice; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D009822:Oils, Volatile / Q000032:analysis / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D016207:Cytokines; D009822:Oils, Volatile; D009569:Nitric Oxide; D015232:Dinoprostone