title: Metal-free oxidative direct C(sp³)-H bond functionalization of ethers with α,α-diaryl allylic alcohols.
abstract: A metal-free method for direct C(sp(3))-H bond functionalization of simple ethers with α,α-diaryl allylic alcohols is described. The established protocol provides facile access to α-aryl-β-oxyalkylated carbonyl ketones via radical addition and a 1,2-aryl migration cascade process. An application of the product has been demonstrated in the synthesis of a serotonin antagonist.
authors.affiliation: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, People's Republic of China. xuxp@suda.edu.cn shunjun@suda.edu.cn.
authors.forename: Xue-Qiang
authors.initials: XQ
authors.lastname: Chu
authors.forename: Hua
authors.initials: H
authors.lastname: Meng
authors.forename: You
authors.initials: Y
authors.lastname: Zi
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Xu
authors.forename: Shun-Jun
authors.initials: SJ
authors.lastname: Ji