title: Cytosolic lipid droplets: from mechanisms of fat storage to disease.
abstract: The lipid droplet (LD) is a phylogenetically conserved organelle. In eukaryotes, it is born from the endoplasmic reticulum, but unlike its parent organelle, LDs are the only known cytosolic organelles that are micellar in structure. LDs are implicated in numerous physiological and pathophysiological functions. Many aspects of the LD has captured the attention of diverse scientists alike and has recently led to an explosion in information on the LD biogenesis, expansion and fusion, identification of LD proteomes and diseases associated with LD biology. This review will provide a brief history of this fascinating organelle and provide some contemporary views of unanswered questions in LD biogenesis.
authors.affiliation: Program in Cardiovascular & Metabolic Disorders, Duke-NUS Graduate Medical School Singapore , Singapore , and.
authors.forename: David A
authors.initials: DA
authors.lastname: Gross
authors.forename: David L
authors.initials: DL
authors.lastname: Silver
mesh_terms: D000818:Animals; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism / Q000473:pathology; D006801:Humans; D066292:Lipid Droplets / Q000737:chemistry / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology*; D050356:Lipid Metabolism; D052439:Lipid Metabolism Disorders / Q000378:metabolism* / Q000473:pathology; D000070778:Perilipin-1; D010750:Phosphoproteins / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D000070778:Perilipin-1; D010750:Phosphoproteins; D002265:Carboxylic Ester Hydrolases
keywords: Adipose; diabetes; endoplasmic reticulum; evolution; lipid droplets; lipodystrophy; phospholipid; triglyceride