title: Immunomodulatory properties of carbon nanotubes are able to compensate immune function dysregulation caused by microgravity conditions.
abstract: Spaceflights lead to dysregulation of the immune cell functionality affecting the expression of activation markers and cytokine production. Short oxidized multi-walled carbon nanotubes functionalized by 1,3-dipolar cycloaddition have been reported to activate immune cells. In this Communication we have performed surface marker assays and multiplex ELISA on primary monocytes and T cells under microgravity. We have discovered that carbon nanotubes, through their immunostimulatory properties, are able to fight spaceflight immune system dysregulations.
authors.affiliation: Dipartimento di Scienze Biomediche, Università degli studi di Sassari, 07100 Sassari, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Crescio
authors.forename: Marco
authors.initials: M
authors.lastname: Orecchioni
authors.forename: Cécilia
authors.initials: C
authors.lastname: Ménard-Moyon
authors.forename: Francesco
authors.initials: F
authors.lastname: Sgarrella
authors.forename: Proto
authors.initials: P
authors.lastname: Pippia
authors.forename: Roberto
authors.initials: R
authors.lastname: Manetti
authors.forename: Alberto
authors.initials: A
authors.lastname: Bianco
authors.forename: Lucia Gemma
authors.initials: LG
authors.lastname: Delogu
mesh_terms: D002478:Cells, Cultured; D016207:Cytokines / Q000032:analysis / Q000378:metabolism; D006801:Humans; D007155:Immunologic Factors / Q000737:chemistry* / Q000494:pharmacology; D009000:Monocytes / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D037742:Nanotubes, Carbon / Q000737:chemistry*; D013601:T-Lymphocytes / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D014893:Weightlessness
chemical_list: D016207:Cytokines; D007155:Immunologic Factors; D037742:Nanotubes, Carbon