title: The assessment of the T102C polymorphism of the 5HT2a receptor gene, 3723G/A polymorphism of the NMDA receptor 3A subunit gene (GRIN3A) and 421C/A polymorphism of the NMDA receptor 2B subunit gene (GRIN2B) among cardiac surgery patients with and without delirium.
abstract: OBJECTIVE
  The studies regarding the role of genes polymorphism in development of postoperative delirium are extremely rare. Therefore, we investigated the potential association of polymorphism in 5HT2a receptor gene and N-methyl-d-aspartate (NMDA) receptor 3A and 2B subunits genes with postoperative delirium.
  
  
  METHODS
  We conducted a prospective, nested, case-control study. For analysis, 3723 G/A (rs3739722) polymorphism in the GRIN3A gene, 421 C/A (rs3764028) polymorphism in the GRIN2B gene and T102C (rs6313) polymorphism in the 5HT2A gene were selected.
  
  
  RESULTS
  Genetic analysis confirmed that there were significant differences in genotype frequencies for 3723 G/A between delirium patients and controls. No other significant associations were observed. Moreover, according to the multivariate conditional logistic regression analysis the presence of AG haplotype of GRIN3A gene was independently associated with postoperative delirium.
  
  
  CONCLUSIONS
  These findings suggest that the genetic variations of NR3A subunit of NMDA receptor may be a predisposing factor to delirium among the Polish population of cardiac surgery patients.
authors.affiliation: Department of Old Age Psychiatry and Psychotic Disorders, Medical University of Lodz, Poland. Electronic address: jakub.kazmierski@umed.lodz.pl.
authors.forename: Jakub
authors.initials: J
authors.lastname: Kazmierski
authors.affiliation: Department of Molecular Pathology and Neuropathology; Medical University of Lodz, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Sieruta
authors.affiliation: Department of Anaesthesiology and Intensive Cardiologic Care, 1st Chair of Cardiology and Cardiac Surgery, Medical University of Lodz, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Banys
authors.affiliation: Department of Cardiac Surgery, 1st Chair of Cardiology and Cardiac Surgery, Medical University of Lodz, Poland.
authors.forename: Ryszard
authors.initials: R
authors.lastname: Jaszewski
authors.affiliation: Department of Medical Psychology, Medical University of Lodz, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Sobow
authors.affiliation: Department of Molecular Pathology and Neuropathology; Medical University of Lodz, Poland.
authors.forename: Pawel
authors.initials: P
authors.lastname: Liberski
authors.affiliation: Department of Old Age Psychiatry and Psychotic Disorders, Medical University of Lodz, Poland.
authors.forename: Iwona
authors.initials: I
authors.lastname: Kloszewska
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D003693:Delirium / Q000209:etiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D011044:Poland; D011110:Polymorphism, Genetic; D011183:Postoperative Complications / Q000235:genetics*; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics*
chemical_list: C548929:GRIN3A protein, human; C121001:NR2B NMDA receptor; D044402:Receptor, Serotonin, 5-HT2A; D016194:Receptors, N-Methyl-D-Aspartate
keywords: Cardiac surgery; Coronary artery bypass graft surgery; Delirium; NMDA receptor; Polymorphism