title: Boehmeria nivea attenuates the development of dextran sulfate sodium-induced experimental colitis.
abstract: We examined the therapeutic effect of an ethanol extract derived from Boehmeria nivea (Linn.) Gaudich in a mouse model of experimental colitis. Treatment with 70% ethanol extract derived from B. nivea (EBN) at a dose of 100, 200, or 500 mg/(kg · d) improved colon shortening, body weight, the disease activity index (DAI), and histopathological score of DSS-induced colitis mice. DSS significantly increased the levels of cyclooxygenase-(COX-) 2 in colon tissue relative to that of the untreated control group. EBN administered at 100, 200, or 500 mg/(kg · d) reduced COX-2 levels in the DSS-treated mice. In addition, EBN decreased the DSS-induced secretion of the inflammatory cytokine interleukin-6 (IL-6) and chemokine monocyte chemotactic protein-1 (MCP-1). Taken together, these data suggest that B. nivea extract is effective in preventing colitis.
authors.affiliation: Department of Food Biotechnology, University of Science & Technology, 217 Gajeong-ro, Yuseong-gu, Daejeon 305-333, Republic of Korea.
authors.forename: Eun Ju
authors.initials: EJ
authors.lastname: Shin
authors.affiliation: Korea Food Research Institute, 1201 Anyangpangyoro, Bundang-gu, Seongnam-si, Gyeonggi-do 463-746, Republic of Korea.
authors.forename: Mi Jeong
authors.initials: MJ
authors.lastname: Sung
authors.affiliation: Korea Food Research Institute, 1201 Anyangpangyoro, Bundang-gu, Seongnam-si, Gyeonggi-do 463-746, Republic of Korea.
authors.forename: Hye Jeong
authors.initials: HJ
authors.lastname: Yang
authors.affiliation: Korea Food Research Institute, 1201 Anyangpangyoro, Bundang-gu, Seongnam-si, Gyeonggi-do 463-746, Republic of Korea.
authors.forename: Myung Sunny
authors.initials: MS
authors.lastname: Kim
authors.affiliation: Department of Food Biotechnology, University of Science & Technology, 217 Gajeong-ro, Yuseong-gu, Daejeon 305-333, Republic of Korea ; Korea Food Research Institute, 1201 Anyangpangyoro, Bundang-gu, Seongnam-si, Gyeonggi-do 463-746, Republic of Korea.
authors.forename: Jin-Taek
authors.initials: JT
authors.lastname: Hwang
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D032402:Boehmeria / Q000737:chemistry*; D018932:Chemokine CCL2 / Q000097:blood; D003092:Colitis / Q000139:chemically induced* / Q000188:drug therapy*; D016264:Dextran Sulfate / Q000633:toxicity*; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010936:Plant Extracts / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D018932:Chemokine CCL2; D015850:Interleukin-6; D010936:Plant Extracts; D016264:Dextran Sulfate