title: Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the US Multi-Society Task Force on colorectal cancer.
abstract: The Multi-Society Task Force, in collaboration with invited experts, developed guidelines to assist health care providers with the appropriate provision of genetic testing and management of patients at risk for and affected with Lynch syndrome as follows: Figure 1 provides a colorectal cancer risk assessment tool to screen individuals in the office or endoscopy setting; Figure 2 illustrates a strategy for universal screening for Lynch syndrome by tumor testing of patients diagnosed with colorectal cancer; Figures 3-6 provide algorithms for genetic evaluation of affected and at-risk family members of pedigrees with Lynch syndrome; Table 10 provides guidelines for screening at-risk and affected persons with Lynch syndrome; and Table 12 lists the guidelines for the management of patients with Lynch syndrome. A detailed explanation of Lynch syndrome and the methodology utilized to derive these guidelines, as well as an explanation of, and supporting literature for, these guidelines are provided.
authors.affiliation: Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address: fgiardi@jhmi.edu.
authors.forename: Francis M
authors.initials: FM
authors.lastname: Giardiello
authors.affiliation: Yale University School of Medicine, New Haven, Connecticut.
authors.forename: John I
authors.initials: JI
authors.lastname: Allen
authors.affiliation: Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: Axilbund
authors.affiliation: Baylor University Medical Center at Dallas, Texas.
authors.forename: C Richard
authors.initials: CR
authors.lastname: Boland
authors.affiliation: Cleveland Clinic, Cleveland, Ohio.
authors.forename: Carol A
authors.initials: CA
authors.lastname: Burke
authors.affiliation: University of Utah, Salt Lake City, Utah.
authors.forename: Randall W
authors.initials: RW
authors.lastname: Burt
authors.affiliation: Cleveland Clinic, Cleveland, Ohio.
authors.forename: James M
authors.initials: JM
authors.lastname: Church
authors.affiliation: VA Puget Sound Health Care System, Seattle, Washington; University of Washington, Seattle, Washington.
authors.forename: Jason A
authors.initials: JA
authors.lastname: Dominitz
authors.affiliation: Eastern Virginia Medical School, Norfolk, Virginia.
authors.forename: David A
authors.initials: DA
authors.lastname: Johnson
authors.affiliation: Stanford University, Palo Alto, California.
authors.forename: Tonya
authors.initials: T
authors.lastname: Kaltenbach
authors.affiliation: Kaiser Permanente Medical Center, Walnut Creek, California.
authors.forename: Theodore R
authors.initials: TR
authors.lastname: Levin
authors.affiliation: Oregon Health and Science University, Portland, Oregon.
authors.forename: David A
authors.initials: DA
authors.lastname: Lieberman
authors.affiliation: White River Junction VA Medical Center, White River Junction, Vermont; Geisel School of Medicine at Dartmouth, White River Junction, Vermont.
authors.forename: Douglas J
authors.initials: DJ
authors.lastname: Robertson
authors.affiliation: Brigham and Women's Hospital, Boston, Massachusetts; Dana Farber Cancer Institute, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.
authors.forename: Sapna
authors.initials: S
authors.lastname: Syngal
authors.affiliation: Indiana University School of Medicine, Indianapolis, Indiana.
authors.forename: Douglas K
authors.initials: DK
authors.lastname: Rex
mesh_terms: D000465:Algorithms; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D005762:Gastroenterology / Q000592:standards*; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000592:standards*; D015316:Genetic Therapy / Q000592:standards*; D006801:Humans; D010375:Pedigree; D011237:Predictive Value of Tests; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors
keywords: Colorectal Cancer; Genetic Testing; Lynch Syndrome