title: Immunoexpression of transforming growth factor beta and interferon gamma in radicular and dentigerous cysts.
abstract: BACKGROUND
  The aim of this study was to evaluate and compare the immunohistochemical expression of transforming growing factor beta (TGF-β) and interferon gamma (IFN-γ) between radicular cysts (RCs) and dentigerous cysts (DCs).
  
  
  METHODS
  Twenty RCs and DCs were selected for analysis of the immunoexpression of TGF-β and IFN-γ in the epithelium and capsule.
  
  
  RESULTS
  The cell reactivity of TGF-β and IFN-γ in the lining epithelium and capsule of RCs showed no significant differences when compared with DCs (P > .05). There was a tendency of a higher expression of TGF-β in the capsule of DCs.
  
  
  CONCLUSIONS
  Our results showed the presence of TGF-β and IFN-γ in RCs and DCs, supporting the hypothesis that both participate in the development of these lesions, where IFN-γ usually plays a role in bone resorption, which is counterbalanced by the osteoprotective activity performed by TGF-β.
authors.affiliation: Postgraduate Program, Oral Pathology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
authors.forename: Maiara
authors.initials: M
authors.lastname: de Moraes
authors.affiliation: Postgraduate Program, Oral Pathology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
authors.forename: Pedro Carlos
authors.initials: PC
authors.lastname: da Rocha Neto
authors.affiliation: Postgraduate Program, Oral Pathology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
authors.forename: Felipe Rodrigues
authors.initials: FR
authors.lastname: de Matos
authors.affiliation: Postgraduate Program, Oral Pathology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
authors.forename: Maria Luiza Diniz de Sousa
authors.initials: ML
authors.lastname: Lopes
authors.affiliation: Department of Statistics, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
authors.forename: Paulo Roberto Medeiros
authors.initials: PR
authors.lastname: de Azevedo
authors.affiliation: Postgraduate Program, Oral Pathology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil. Electronic address: antoniodelisboa@uol.com.br.
authors.forename: Antonio de Lisboa Lopes
authors.initials: Ade L
authors.lastname: Costa
mesh_terms: D000293:Adolescent; D000328:Adult; D002467:Cell Nucleus / Q000276:immunology; D002648:Child; D003593:Cytoplasm / Q000276:immunology; D003803:Dentigerous Cyst / Q000276:immunology*; D004847:Epithelial Cells / Q000276:immunology; D004848:Epithelium / Q000276:immunology; D005260:Female; D005347:Fibroblasts / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D007371:Interferon-gamma / Q000032:analysis*; D008214:Lymphocytes / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology; D010950:Plasma Cells / Q000276:immunology; D011842:Radicular Cyst / Q000276:immunology*; D016212:Transforming Growth Factor beta / Q000032:analysis*; D055815:Young Adult
chemical_list: D016212:Transforming Growth Factor beta; D007371:Interferon-gamma
keywords: Dentigerous cyst; immunohistochemistry; interferon gamma; radicular cyst; transforming growth factors