title: Timing of events during deglutition after chemoradiation therapy for oropharyngeal carcinoma.
abstract: BACKGROUND
  The purpose of this study was to determine if persistent changes in the duration of bolus movement through the pharynx and bolus movement coordination with pharyngeal swallowing gestures occur after treatment of oropharyngeal carcinoma with chemoradiation therapy.
  
  
  METHODS
  The timing of bolus movement and coordination with swallowing gestures was evaluated in 30 patients using a modified barium swallowing study at least 1 year after completion of treatment. Patients were recruited irrespective of any swallowing complaints. The mean of each measure from the study subjects was compared to those from a group of age-matched controls.
  
  
  RESULTS
  Bolus transit duration in the study population was unchanged compared with normal controls. Unlike normal controls, the patients were found to allow the bolus to arrive in the vallecula before the initiation of swallowing gestures that resulted in a swallow. Earlier opening of the upper esophageal sphincter was found for a 1-cc bolus (p = .004). For the 20 cc bolus size, the onset of hyoid and aryepiglottic fold elevation was delayed (p = .029 and .037, respectively). Gesture timing did not change to accommodate larger bolus sizes, as it normally does, resulting in a delay in airway protection for the 20-cc bolus.
  
  
  CONCLUSIONS
  Patients are able to move a liquid bolus through the pharynx in a timely manner. However, patients are unable to modify swallowing gestures to safely protect the airway.
authors.affiliation: Division of Otolaryngology, University of Utah, Salt Lake City, Utah.
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Kendall
authors.affiliation: Department of Communication Disorders, Brigham Young University, Provo, Utah.|Voice Disorders Center, University of Utah, Salt Lake City, Utah.
authors.forename: Kristine
authors.initials: K
authors.lastname: Tanner
authors.affiliation: Minneapolis VA Medical Center, Minneapolis, Minnesota.
authors.forename: Steven R
authors.initials: SR
authors.lastname: Kosek
mesh_terms: D000368:Aged; D001466:Barium Sulfate / Q000494:pharmacology; D002277:Carcinoma / Q000628:therapy*; D016022:Case-Control Studies; D059248:Chemoradiotherapy / Q000009:adverse effects*; D003287:Contrast Media / Q000494:pharmacology; D003679:Deglutition; D003680:Deglutition Disorders / Q000175:diagnosis* / Q000209:etiology*; D005471:Fluoroscopy; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000628:therapy*; D018570:Risk Assessment; D013997:Time Factors; D014741:Video Recording
chemical_list: D003287:Contrast Media; D001466:Barium Sulfate
keywords: chemoradiation; deglutition; dysphagia; oropharyngeal carcinoma; swallowing; swallowing coordination