title: A cyclization-rearrangement cascade for the synthesis of structurally complex chiral gold(I)-aminocarbene complexes.
abstract: A facile synthesis of chiral cyclic alkyl aminocarbene-gold(I) complexes from gold-free 1,7-enyne substrates was developed. The novel cyclization-rearrangement reaction sequence is triggered by the addition of (Me2S)AuCl to different 1,7-enynes and leads to structurally unique carbene-gold(I) complexes in high yields. These novel complexes are catalytically active and inhibit the proliferation of different human cancer cell lines.
authors.affiliation: Max-Planck-Institut für molekulare Physiologie, Otto-Hahn-Strasse 11, 44227 Dortmund (Germany).
authors.forename: Filip
authors.initials: F
authors.lastname: Kolundžić
authors.forename: Annamalai
authors.initials: A
authors.lastname: Murali
authors.forename: Patricia
authors.initials: P
authors.lastname: Pérez-Galán
authors.forename: Jonathan O
authors.initials: JO
authors.lastname: Bauer
authors.forename: Carsten
authors.initials: C
authors.lastname: Strohmann
authors.forename: Kamal
authors.initials: K
authors.lastname: Kumar
authors.forename: Herbert
authors.initials: H
authors.lastname: Waldmann
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D003500:Cyclization; D004148:Dioxolanes / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D004148:Dioxolanes; C504703:aminocarbene; D006046:Gold
keywords: carbenes; cyclization; enynes; organometallic complexes