title: Esophageal adenocarcinoma with white opaque substance observed by magnifying endoscopy with narrow band imaging.
abstract: White opaque substance (WOS) is observed in the gastric neoplasia of 0-IIa type using magnifying endoscopy with narrow band imaging (NBI-ME). Colonic and duodenal neoplasms with WOS have also been reported. Immunohistochemical examination with adipophilin reveals WOS in gastric neoplasms as lipid droplets, and WOS is specific for neoplasm with intestinal or gastrointestinal phenotype. We herein report a case of adenocarcinoma of the esophagogastric junction with WOS. A male patient in his sixties was found by esophagogastroduodenoscopy to have an esophageal elevated lesion. NBI-ME showed whitish deposits that looked similar to WOS in gastric neoplasms. The patient underwent endoscopic submucosal dissection and the lesion was resected in a single piece. This tumor had diffuse positivity for adipophilin and gastrointestinal phenotype.
authors.affiliation: Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Yoshii
authors.forename: Motohiko
authors.initials: M
authors.lastname: Kato
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Honma
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Fujinaga
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Tsujii
authors.forename: Akira
authors.initials: A
authors.lastname: Maekawa
authors.forename: Takuya
authors.initials: T
authors.lastname: Inoue
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Tomofumi
authors.initials: T
authors.lastname: Akasaka
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Shinzaki
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Nishida
authors.forename: Hideki
authors.initials: H
authors.lastname: Iijima
authors.forename: Masahiko
authors.initials: M
authors.lastname: Tsujii
authors.forename: Eiichi
authors.initials: E
authors.lastname: Morii
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Takehara
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery; D001707:Biopsy, Needle; D004210:Dissection / Q000379:methods; D004938:Esophageal Neoplasms / Q000473:pathology* / Q000601:surgery; D004943:Esophagogastric Junction / Q000473:pathology*; D020701:Esophagoscopes; D004945:Esophagoscopy / Q000295:instrumentation / Q000379:methods*; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D062048:Narrow Band Imaging; D018570:Risk Assessment; D016896:Treatment Outcome
keywords: adenocarcinoma; esophageal cancer; magnifying endoscopy; narrow band imaging (NBI); white opaque substance (WOS)