title: Aging and age-related diseases--from endocrine therapy to target therapy.
abstract: Aging represents an important health issue not only for the individual, but also for society in general. Burdens associated with aging are expanding as longevity increases. This has led to an enhanced focus on issues related to aging and age-related diseases. Until recently, anti-aging endocrine-therapy has been largely limited to hormone-replacement therapy (HRT) that is associated with multiple side effects, including an increased risk of cancer. This has greatly limited the application of HRT in anti-aging therapy. Recently, the focus of anti-aging research has expanded from endocrine signaling pathways to effects on regulatory gene networks. In this regard, the GHRH-GH-IGF-1/Insulin, TOR-S6K1,NAD(+)-Sirtuin, P53, Klotho and APOE pathways have been linked to processes associated with age-related diseases, including cancer, cardiovascular disease, diabetes, osteoporosis, and neurodegenerative diseases, all of which directly influence health in aging, and represent key targets in anti-aging therapy.
authors.affiliation: Department of Plastic and Reconstructive Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China; Institute of Gastroenterology, Zhejiang University (IGZJU), China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Bao
authors.affiliation: Department of Endocrinology and Metabolism, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China; Institute of Gastroenterology, Zhejiang University (IGZJU), China.
authors.forename: Jie
authors.initials: J
authors.lastname: Pan
authors.affiliation: Department of Molecular and Medical Pharmacology, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USA.
authors.forename: Hangfei
authors.initials: H
authors.lastname: Qi
authors.affiliation: Department of Plastic and Reconstructive Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Plastic and Reconstructive Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
authors.forename: Huan
authors.initials: H
authors.lastname: Qian
authors.affiliation: Department of Plastic and Reconstructive Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
authors.forename: Fangzhen
authors.initials: F
authors.lastname: Jiang
authors.affiliation: Department of Plastic and Reconstructive Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
authors.forename: Zheren
authors.initials: Z
authors.lastname: Shao
authors.affiliation: Department of Plastic and Reconstructive Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
authors.forename: Fengzhi
authors.initials: F
authors.lastname: Xu
authors.affiliation: Department of Plastic and Reconstructive Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
authors.forename: Zhiping
authors.initials: Z
authors.lastname: Tao
authors.affiliation: Department of Plastic and Reconstructive Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Ma
authors.affiliation: Clinical Biochemistry Group, Medizinische Klinik und Poliklinik IV, University of Munich, Schillerstrasse 42, D-80336 Munich, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Nelson
authors.affiliation: Department of Plastic and Reconstructive Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. Electronic address: huxueqing@zju.edu.cn.
authors.forename: Xueqing
authors.initials: X
authors.lastname: Hu
mesh_terms: D000375:Aging / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D002318:Cardiovascular Diseases / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D003920:Diabetes Mellitus / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D018507:Gene Expression Regulation, Developmental; D053263:Gene Regulatory Networks; D005966:Glucuronidase / Q000235:genetics / Q000378:metabolism; D013007:Growth Hormone-Releasing Hormone / Q000235:genetics / Q000378:metabolism; D019382:Human Growth Hormone / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000378:metabolism; D000090265:Klotho Proteins; D008136:Longevity; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D010024:Osteoporosis / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D015398:Signal Transduction
chemical_list: D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D013007:Growth Hormone-Releasing Hormone; D005966:Glucuronidase; D000090265:Klotho Proteins
keywords: Age-related diseases; Aging; Endocrine; Gene