title: Antioxidant and α-amylase inhibitory activities of extract and isolates from Zygogynum pancheri subsp. arrhantum.
abstract: One new sesquiterpenoid (5R(*),8R(*),9R(*),10R(*))-cinnamolide (8), and seven known compounds, 5-hydroxy-7-methoxyflavonone (1), 8-hydroxy-3-(4'-hydroxyphenyl)-6,7-(2″,2″-dimethylchromene)-tetralone (2), 8-hydroxy-3-(3',4'-dihydroxyphenyl)-6,7-(2″,2″-dimethylchromene)-tetralone (3), 1β-E-O-p-methoxycinnamoyl-bemadienolide (4), 1β-O-(E-cinnamoyl)-6α-hydroxy-9-epi-polygodial (5), 1β-O-(E-cinnamoyl)-6α-hydroxypolygodial (6), and 1β-O-E-cinnamoylpolygodial (7) were isolated from the ethyl acetate extract of barks of Zygogynum pancheri subsp. arrhantum (Winteraceae). The structures of these molecules were assigned predominantly based on spectral data. The structure of compound 8 was confirmed by X-ray crystallographic analysis. Compounds 2 and 3 exhibited significant antioxidant activity, whereas compounds 1 and 4-7 showed significant α-amylase inhibitory activity.
authors.affiliation: a Laboratory of Chemistry of Natural Substances, Faculty of Sciences of Sfax, University of Sfax , BP "1171", 3000 Sfax , Tunisia.
authors.forename: Henda
authors.initials: H
authors.lastname: Keskes
authors.forename: Marc
authors.initials: M
authors.lastname: Litaudon
authors.forename: Atef
authors.initials: A
authors.lastname: Cherif
authors.forename: Sahla
authors.initials: S
authors.lastname: Belhadj
authors.forename: Besma
authors.initials: B
authors.lastname: Hamdi
authors.forename: Abdelfattah
authors.initials: A
authors.lastname: El Feki
authors.forename: Vincent
authors.initials: V
authors.lastname: Dumontet
authors.forename: Abdelhamid
authors.initials: A
authors.lastname: Ben Salah
authors.forename: Mohamed
authors.initials: M
authors.lastname: Damak
authors.forename: Noureddine
authors.initials: N
authors.lastname: Allouche
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D008968:Molecular Conformation; D015394:Molecular Structure; D010084:Oxidation-Reduction; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D032423:Winteraceae / Q000737:chemistry*; D000516:alpha-Amylases / Q000037:antagonists & inhibitors*
chemical_list: D000975:Antioxidants; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C437376:drimane; D000516:alpha-Amylases
keywords: Zygogynum pancheri; antioxidant; drimane sesquiterpenoids; tetralone; α-amylase