title: Laparoscopy-assisted versus open gastrectomy with D2 lymph node dissection for advanced gastric cancer: a meta-analysis.
abstract: A raising number of surgeons have chosen laparoscopy-assisted gastrectomy (LAG) as an alternative to open gastrectomy (OG) with D2 lymph node dissection for treatment of advanced gastric cancer (ADG). But no meta-analysis has been performed to evaluate the value of LAG versus OG with regard to safety and efficacy for treatment of ADG. A comprehensive literature research was performed in PubMed, Web of Science and Embase to identify studies that compared LAG and OG with D2 lymph node dissection for treatment of ADG. Data of interest were checked and subjected to meta-analysis with RevMan 5.1 software. 11 studies with 1904 patients (982 in LAG and 922 in OG) were enrolled. Pooled risk ratios (RR) and weighted mean difference (WMD) with 95% confidence intervals (CI) were appropriately derived from random-effects models or fixed-effects models. Compared with OG, LAG was associated with less blood loss (WMD = -144.47; P < 0.05), shorter time of first flatus time (WMD = -0.91; P < 0.05) and postoperative hospital stay (WMD = -3.27; P < 0.05), and lower morbidity (RR = 0.70; P < 0.05), but longer operation time (WMD = 41.78; P < 0.05). No significant differences were noted in terms of harvested lymph nodes (WMD = 1.85; P = 0.09), pathological N stage (χ(2) 3.97; P = 0.26), tumor size (WMD = -0.05; P = 0.81), mortality (RR 0.82; P = 0.76), cancer recurrence rate (RR 0.77; P = 0.18) and 3-year overall survival rate (RR 1.09; P = 0.18). Compared with OG, LAG with D2 lymph node dissection for ADG had the advantages of minimal invasion, faster recovery, and fewer complications, and it could achieve the same degree of radicality, harvested lymph nodes, short-term and long-term prognosis as OG, though the operation time was slightly longer.
authors.affiliation: Department of General Surgery, 306 Hospital of PLA Beijing 100101, China ; Department of General Surgery, 306 Teaching Hospital of Peking University Health Science Center Beijing 100101, China.
authors.forename: Yu-Ling
authors.initials: YL
authors.lastname: Huang
authors.affiliation: Department of General Surgery, 306 Hospital of PLA Beijing 100101, China.
authors.forename: Hai-Guan
authors.initials: HG
authors.lastname: Lin
authors.affiliation: Department of General Surgery, 306 Hospital of PLA Beijing 100101, China.
authors.forename: Jian-Wu
authors.initials: JW
authors.lastname: Yang
authors.affiliation: Department of General Surgery, 306 Hospital of PLA Beijing 100101, China.
authors.forename: Fu-Quan
authors.initials: FQ
authors.lastname: Jiang
authors.affiliation: Department of General Surgery, 306 Hospital of PLA Beijing 100101, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, 306 Hospital of PLA Beijing 100101, China.
authors.forename: He-Ming
authors.initials: HM
authors.lastname: Yang
authors.affiliation: Department of General Surgery, 306 Hospital of PLA Beijing 100101, China.
authors.forename: Cheng-Lin
authors.initials: CL
authors.lastname: Li
authors.affiliation: Department of General Surgery, 306 Hospital of PLA Beijing 100101, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Cui
keywords: Advanced gastric cancer; D2 lymph node dissection; laparoscopy-assisted gastrectomy; meta-analysis; open gastrectomy