title: Direct enantioselective vinylogous aldol-cyclization cascade reaction of allyl pyrazoleamides with isatins: asymmetric construction of spirocyclic oxindole-dihydropyranones.
abstract: The first enantioselective vinylogous aldol-cyclization cascade reaction of allyl pyrazoleamides with isatins is reported. With 1 mol% of Takemoto catalyst, optically active spirocyclic oxindole-dihydropyranones were obtained in excellent yields (93-99%) and good-to-excellent enantioselectivities (82-97% ee).
authors.affiliation: Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P. R. China. xinyanwu@ecust.edu.cn.
authors.forename: Tian-Ze
authors.initials: TZ
authors.lastname: Li
authors.forename: Yu
authors.initials: Y
authors.lastname: Jiang
authors.forename: Yu-Qing
authors.initials: YQ
authors.lastname: Guan
authors.forename: Feng
authors.initials: F
authors.lastname: Sha
authors.forename: Xin-Yan
authors.initials: XY
authors.lastname: Wu
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D007211:Indoles / Q000737:chemistry*; D007510:Isatin / Q000737:chemistry*; D000078183:Oxindoles; D011714:Pyrans / Q000737:chemistry*; D011720:Pyrazoles / Q000737:chemistry; D013141:Spiro Compounds / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000577:Amides; D007211:Indoles; D000078183:Oxindoles; D011714:Pyrans; D011720:Pyrazoles; D013141:Spiro Compounds; C022960:2-oxindole; D007510:Isatin; C116609:3-hydroxybutanal