title: Clinico-pathological characteristics of different types of immunodeficiency-associated smooth muscle tumours.
abstract: Rare Epstein-Barr virus (EBV)+ smooth muscle tumours (SMT) manifest typically under immunosuppression. Three major subtypes are known: human immunodeficiency virus-associated (HIV-SMT), after transplantation (PTSMT) or associated with congenital immunodeficiency syndromes (CI-SMT). So far, there are no analyses which compare the clinico-pathological characteristics of all three subtypes. Case reports and case series on these three tumour types were collected (1990-2012). Meta-data analysis was performed for identification of similarities and differences. A total of 73 HIV-SMT, 66 PTSMT and 9 CI-SMT were evaluated. There was a slight female predominance (55-67%). Children were affected nearly equally in HIV-SMT (33%) and PTSMT (35%), while all CI-SMT occurred in children. HIV-SMT manifested preferentially in the central nervous system, gut/liver, skin, lungs/larynx/pharynx and adrenal glands. PTSMT were predominantly found in the liver, lungs/larynx/pharynx, gut/spleen and brain. CI-SMT were often found in lungs/larynx, brain, liver, adrenal glands and spleen. Antecedent EBV+ lymphoproliferations manifested more often in PTSMT. In all three tumour subtypes, survival analyses did not show any significant differences regarding surgical therapeutic approaches, the occurrence of multiple tumours, tumour size or sarcoma-like histological features. HIV-SMT had the poorest overall survival, which might be attributed to HIV-associated infectious complications.
authors.affiliation: Institute of Pathology, Hannover Medical School (MHH), Hanover, Germany. Electronic address: hussein.kais@MH-Hannover.de.
authors.forename: Kais
authors.initials: K
authors.lastname: Hussein
authors.affiliation: Institute of Pathology, Hannover Medical School (MHH), Hanover, Germany.
authors.forename: Berenice
authors.initials: B
authors.lastname: Rath
authors.affiliation: Institute of Pathology, Hannover Medical School (MHH), Hanover, Germany.
authors.forename: Britta
authors.initials: B
authors.lastname: Ludewig
authors.affiliation: Institute of Pathology, Hannover Medical School (MHH), Hanover, Germany.
authors.forename: Hans
authors.initials: H
authors.lastname: Kreipe
authors.affiliation: Institute of Pathology, Hannover Medical School (MHH), Hanover, Germany.
authors.forename: Danny
authors.initials: D
authors.lastname: Jonigk
mesh_terms: D015331:Cohort Studies; D017074:Common Variable Immunodeficiency / Q000276:immunology / Q000473:pathology / Q000821:virology; D020031:Epstein-Barr Virus Infections / Q000473:pathology; D006678:HIV / Q000302:isolation & purification*; D006801:Humans; D011379:Prognosis; D018235:Smooth Muscle Tumor / Q000276:immunology / Q000473:pathology* / Q000821:virology
keywords: Congenital immunodeficiency syndrome; EBV; Epstein–Barr virus; HIV; Human immunodeficiency virus; Smooth muscle tumours; Transplantation