title: Facile access to functionalized spiro[indoline-3,2'-pyrrole]-2,5'-diones via post-Ugi domino Buchwald-Hartwig/Michael reaction.
abstract: A novel access to spiro[indoline-3,2'-pyrrole]-2,5'-diones is presented via a palladium-catalyzed post-Ugi cascade cyclization approach involving a Buchwald-Hartwig/Michael reaction sequence. The method allows the easy construction of a library of spirooxindoles in moderate to good yields starting from readily available precursors. In addition, alkynoic acids are replaced with α,β-unsaturated acids leading to variably substituted spirooxindoles.
authors.affiliation: Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven) , Celestijnenlaan 200F, B-3001 Leuven, Belgium.
authors.forename: Nandini
authors.initials: N
authors.lastname: Sharma
authors.forename: Zhenghua
authors.initials: Z
authors.lastname: Li
authors.forename: Upendra K
authors.initials: UK
authors.lastname: Sharma
authors.forename: Erik V
authors.initials: EV
authors.lastname: Van der Eycken