title: Paravalvular leak closure with the Amplatzer Vascular Plug III device: immediate and short-term results.
abstract: OBJECTIVE
  Percutaneous paravalvular leak closure is a complex procedure with varying success rates; the lack of closure devices specifically designed for this purpose has hampered this technique. The characteristics of the Amplatzer Vascular Plug III appear to be well suited for paravalvular leak closures; however, the available data are limited to case reports or small series of patients. The aim of this study was to analyze the feasibility and efficacy of paravalvular leak with this device.
  
  
  METHODS
  The immediate and 90-day safety and efficacy of mitral and aortic paravalvular leak closures performed with this device at our hospital were analyzed.
  
  
  RESULTS
  Percutaneous repair of 34 paravalvular leaks (27 mitral, 7 aortic) was attempted in 33 patients. The device was successfully implanted in 93.9% (in 2 patients, a second planned procedure was needed), and successful closure (defined as regurgitation reduction ≥ 1 grade) was achieved in 90.9% of patients. Complications included emergency surgery due to disc interference (n=1) and blood transfusion (n=3). There were no reports of procedure-related death, myocardial infarction, or stroke. At 90 days, survival was 100%, and 90.3% of patients showed significant clinical improvement; 4 patients developed vascular complications (pseudoaneurysm).
  
  
  CONCLUSIONS
  Mitral and aortic paravalvular leak closure with the Amplatzer Vascular Plug III is feasible and safe, with high clinical and echocardiographic success rates.
authors.affiliation: Servicio de Cardiología, Hospital Universitario de Salamanca, Salamanca, Spain. Electronic address: cruzgonzalez.ignacio@gmail.com.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Cruz-Gonzalez
authors.affiliation: Servicio de Cardiología, Hospital Universitario de Salamanca, Salamanca, Spain.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Rama-Merchan
authors.affiliation: Servicio de Cardiología, Hospital Universitario de Salamanca, Salamanca, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Arribas-Jimenez
authors.affiliation: Servicio de Cardiología, Hospital Universitario de Salamanca, Salamanca, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Rodriguez-Collado
authors.affiliation: Servicio de Cardiología, Hospital Universitario de Salamanca, Salamanca, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Martin-Moreiras
authors.affiliation: Servicio de Cardiología, Hospital Universitario de Salamanca, Salamanca, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Cascon-Bueno
authors.affiliation: Servicio de Cardiología, Hospital Universitario de Salamanca, Salamanca, Spain.
authors.forename: Candido Martin
authors.initials: CM
authors.lastname: Luengo
mesh_terms: D000368:Aged; D001022:Aortic Valve Insufficiency / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery*; D006328:Cardiac Catheterization / Q000379:methods*; D006348:Cardiac Surgical Procedures / Q000295:instrumentation*; D019560:Echocardiography, Three-Dimensional; D017548:Echocardiography, Transesophageal / Q000379:methods; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery*; D011475:Prosthesis Failure; D012086:Reoperation; D055989:Septal Occluder Device; D016896:Treatment Outcome
keywords: Device; Dispositivo; Fugas periprotésicas; Outcomes; Paravalvular leaks; Resultados