title: A Comparative Study of Serum Uric Acid levels and Lipid Ratios in Coronary Artery Disease Patients.
abstract: BACKGROUND
  Coronary Artery Disease (CAD) appears to be common in the Indian population of different geographical origins, religions and languages. Measurement of lipid fractions and ratios are widely recommended for risk assessment. A few studies have shown that serum uric acid plays a role in the development of cardiovascular morbidity. Very few reports are cited linking serum uric acid with the lipid fraction in CAD.
  
  
  OBJECTIVE
  To find the significance of non-HDL cholesterol, LDL-c/HDL-c ratio, TC/HDL ratio and serum uric acid level in CAD patients.
  
  
  METHODS
  In this study, we included fifty CAD patients as subjects and an equal number of controls. Both subjects and controls were assessed for anthropometric, physiological and biochemical parameters.
  
  
  RESULTS
  The present study showed significant increased levels of total cholesterol (p=0.002), TAGs (p<0.001), HDL (p=0.005), LDL (p<0.006) and non-HDL cholesterol (p<0.001). LDL-c/HDL-c ratio (p<0.001) and TC/HDL ratio (p<0.001) in CAD patients (subjects) were also significant when compared to controls. Uric acid level in CAD patients was increased (p<0.001).
  
  
  CONCLUSIONS
  Serum Uric Acid, TC/HDL and LDL/HDL ratios could be regarded as objective markers, in association with existing atherogenic dyslipidemia in patients with CAD.
authors.affiliation: Department of Biochemistry, Mahatma Gandhi Medical College and Research Institute (SBV), Pillaiyarkuppam, Puducherry, India;
authors.forename: R
authors.initials: R
authors.lastname: Sathiya
authors.affiliation: Department of Biochemistry, Mahatma Gandhi Medical College and Research Institute (SBV), Pillaiyarkuppam, Puducherry, India;
authors.forename: V Kuzhandai
authors.initials: VK
authors.lastname: Velu
authors.affiliation: Department of Biochemistry, Mahatma Gandhi Medical College and Research Institute (SBV), Pillaiyarkuppam, Puducherry, India;
authors.forename: G
authors.initials: G
authors.lastname: Niranjan
authors.affiliation: Department of Biochemistry, Mahatma Gandhi Medical College and Research Institute (SBV), Pillaiyarkuppam, Puducherry, India;
authors.forename: A R
authors.initials: AR
authors.lastname: Srinivasan
authors.affiliation: Department of Cardiology, Mahatma Gandhi Medical College and Research Institute (SBV), Pillaiyarkuppam, Puducherry, India.
authors.forename: Ganesh B
authors.initials: GB
authors.lastname: Amirtha
authors.affiliation: Department of Biochemistry, Mahatma Gandhi Medical College and Research Institute (SBV), Pillaiyarkuppam, Puducherry, India;
authors.forename: R
authors.initials: R
authors.lastname: Ramesh
authors.affiliation: Department of Biochemistry, Mahatma Gandhi Medical College and Research Institute (SBV), Pillaiyarkuppam, Puducherry, India;
authors.forename: M Sathish
authors.initials: MS
authors.lastname: Babu
authors.affiliation: Department of Biochemistry, Mahatma Gandhi Medical College and Research Institute (SBV), Pillaiyarkuppam, Puducherry, India;
authors.forename: Subiman
authors.initials: S
authors.lastname: Saha
keywords: Coronary Artery Disease; Lipid Ratio; Serum Uric Acid