title: Glutathion-S-Transferase P1 polymorphisms association with broncopulmonary dysplasia in preterm infants.
abstract: BACKGROUND
  Oxidative stress, characterized by the excretion of pre-oxidative and anti-oxidative proteases, has a key role in the pathogenesis of bronchopulmonary dysplasia (BPD). One of the many host anti-oxidant enzymes is glutathione-S-transferase P1 (GSTP1), with three polymorphic alleles having been identified: homozygous ile, heterozygous ile/val and homozygous val isomorph. The aim of this study was to examine the genetic predisposition to BPD in the GSTP1 polymorphisms.
  
  
  METHODS
  A prospective case-control study was carried out in the 2nd Neonatal Intensive Care Unit of Aristotle University in Thessaloniki, Greece during 2008. The genetic polymorphisms of GSTP1 in 28 preterms <32 weeks gestational age (GA) with BPD compared to 74 controls (33 preterms without BPD and 41 healthy terms) were examined.
  
  
  RESULTS
  The homozygous ile isomorph was predominant in all groups (preterms with BPD: 82%, preterms without BPD: 70%, healthy terms: 78%), followed by the heterozygous ile/val (14%, 18% and 20% respectively) and the homozygous val isomorph (4%, 12% and 2% respectively). The homozygous ile isomorph was also identified in the majority of preterms with mild (80%), moderate (100%) and severe (73%) BPD. The GSTP1 genetic distribution did not differ between the groups and GSTP1 polymorphisms were not associated with the severity of BPD.
  
  
  CONCLUSIONS
  This study could not confirm an association between GSTP1 polymorphisms and the development of BPD or the severity of the disease.
authors.affiliation: 2nd NICU and Neonatology Department, Papageorgiou General Hospital, Aristotle University of Thessaloniki, Greece.
authors.forename: P
authors.initials: P
authors.lastname: Karagianni
authors.affiliation: 2nd NICU and Neonatology Department, Papageorgiou General Hospital, Aristotle University of Thessaloniki, Greece.
authors.forename: D
authors.initials: D
authors.lastname: Rallis
authors.affiliation: Department of General Biology, Medical School, Aristotle University of Thessaloniki, Greece.
authors.forename: L
authors.initials: L
authors.lastname: Fidani
authors.affiliation: 2nd NICU and Neonatology Department, Papageorgiou General Hospital, Aristotle University of Thessaloniki, Greece.
authors.forename: M
authors.initials: M
authors.lastname: Porpodi
authors.affiliation: Department of General Biology, Medical School, Aristotle University of Thessaloniki, Greece.
authors.forename: K
authors.initials: K
authors.lastname: Kalinderi
authors.affiliation: 2nd NICU and Neonatology Department, Papageorgiou General Hospital, Aristotle University of Thessaloniki, Greece.
authors.forename: C
authors.initials: C
authors.lastname: Tsakalidis
authors.affiliation: 2nd NICU and Neonatology Department, Papageorgiou General Hospital, Aristotle University of Thessaloniki, Greece.
authors.forename: N
authors.initials: N
authors.lastname: Nikolaidis
keywords: Bronchopulmonary dysplasia; genetic predisposition; glutathione-S-transferase polymorphism; prematurity