title: Torrubiellone E, an antimalarial N-hydroxypyridone alkaloid from the spider pathogenic fungus Torrubiella longissima BCC 2022.
abstract: Torrubiellone E (1), a new N-hydroxypyridone alkaloid, was isolated from the spider pathogenic fungus Torrubiella longissima BCC 2022, together with the known compounds, torrubiellones A (2) and B (3), and JBIR-130 (4). Compound 1 exhibited antimalarial activity against Plasmodium falciparum K1 with an IC5 value of 3.2 microg/mL, while it also showed weak cytotoxic activities.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Isaka
authors.forename: Rachada
authors.initials: R
authors.lastname: Haritakun
authors.forename: Kamolphan
authors.initials: K
authors.lastname: Intereya
authors.forename: Donnaya
authors.initials: D
authors.lastname: Thanakitpipattana
authors.forename: Nigel L
authors.initials: NL
authors.lastname: Hywel-Jones
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D006999:Hypocreales / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D011728:Pyridones / Q000302:isolation & purification* / Q000494:pharmacology; D013112:Spiders / Q000382:microbiology*
chemical_list: D000470:Alkaloids; D000962:Antimalarials; D011728:Pyridones; C000591726:torrubiellone E