title: The effect of 1,8-cineole inhalation on preoperative anxiety: a randomized clinical trial.
abstract: The aim of this study was to investigate the effect of inhalation of eucalyptus oil and its constituents on anxiety in patients before selective nerve root block (SNRB). This study was a randomized controlled trial carried out in 62 patients before SNRB. The patients were randomized to inhale limonene, 1,8-cineole, or eucalyptus oil, each at concentrations of 1% vol/vol in almond oil or almond oil (control). Anxiety-visual analog scale (A-VAS), state-trait anxiety inventory (STAI), profile of mood states (POMS), pain-visual analog scale (P-VAS), blood pressure, and pulse rate were measured before and after inhalation prior to SNRB. Measures of anxiety, including A-VAS (P < 0.001), STAI (P = 0.005), and POMS (P < 0.001), were significantly lower in 1,8-cineole than in the control group and significantly greater in 1,8-cineole than in the eucalyptus group in A-VAS. P-VAS was significantly lower after than before inhalation of limonene, 1,8-cineole, and eucalyptus, despite having no significant difference in the four groups compared with control group. 1,8-Cineole, a major constituent of eucalyptus, was effective in decreasing anxiety before SNRB. The present findings suggest that inhalation of 1,8-cineole may be used to relieve anxiety before, during, and after various operations, in addition to SNRB.
authors.affiliation: Department of Basic Nursing Science, School of Nursing, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 136-701, Republic of Korea.
authors.forename: Ka Young
authors.initials: KY
authors.lastname: Kim
authors.affiliation: Department of Basic Nursing Science, School of Nursing, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 136-701, Republic of Korea.
authors.forename: Hyo Jin
authors.initials: HJ
authors.lastname: Seo
authors.affiliation: Department of Physiology and Biophysics, School of Medicine, Eulji University, Daejeon 301-746, Republic of Korea.
authors.forename: Sun Seek
authors.identifier: 0000-0001-7144-1987
authors.initials: SS
authors.lastname: Min
authors.affiliation: Department of Premedicine, School of Medicine, Eulji University, Daejeon 301-746, Republic of Korea.
authors.forename: Mira
authors.initials: M
authors.lastname: Park
authors.affiliation: Department of Basic Nursing Science, School of Nursing, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 136-701, Republic of Korea.
authors.forename: Geun Hee
authors.identifier: 0000-0002-2986-9688
authors.initials: GH
authors.lastname: Seol