title: Mechanical downsizing of a gadolinium(III)-based metal-organic framework for anticancer drug delivery.
abstract: A Gd(III) -based porous metal-organic framework (MOF), Gd-pDBI, has been synthesized using fluorescent linker pDBI (pDBI=(1,4-bis(5-carboxy-1H-benzimidazole-2-yl)benzene)), resulting in a three-dimensional interpenetrated structure with a one-dimensional open channel (1.9×1.2 nm) filled with hydrogen-bonded water assemblies. Gd-pDBI exhibits high thermal stability, porosity, excellent water stability, along with organic-solvent and mild acid and base stability with retention of crystallinity. Gd-pDBI was transformed to the nanoscale regime (ca. 140 nm) by mechanical grinding to yield MG-Gd-pDBI with excellent water dispersibility (>90 min), maintaining its porosity and crystallinity. In vitro and in vivo studies on MG-Gd-pDBI revealed its low blood toxicity and highest drug loading (12 wt %) of anticancer drug doxorubicin in MOFs reported to date with pH-responsive cancer-cell-specific drug release.
authors.affiliation: Physical/Materials Chemistry Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune-411008 (India), Fax: (+91) 20-25902636.
authors.forename: Tanay
authors.initials: T
authors.lastname: Kundu
authors.forename: Shouvik
authors.initials: S
authors.lastname: Mitra
authors.forename: Prasun
authors.initials: P
authors.lastname: Patra
authors.forename: Arunava
authors.initials: A
authors.lastname: Goswami
authors.forename: David
authors.initials: D
authors.lastname: Díaz Díaz
authors.forename: Rahul
authors.initials: R
authors.lastname: Banerjee
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001555:Benzene Derivatives / Q000737:chemistry* / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000493:pharmacokinetics; D004317:Doxorubicin / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D005456:Fluorescent Dyes / Q000737:chemistry / Q000493:pharmacokinetics; D005682:Gadolinium / Q000737:chemistry* / Q000493:pharmacokinetics; D006801:Humans; D051379:Mice; D008958:Models, Molecular; D009369:Neoplasms / Q000188:drug therapy; D009942:Organometallic Compounds / Q000737:chemistry* / Q000493:pharmacokinetics; D016062:Porosity
chemical_list: D000970:Antineoplastic Agents; D001555:Benzene Derivatives; D003692:Delayed-Action Preparations; D005456:Fluorescent Dyes; D009942:Organometallic Compounds; D004317:Doxorubicin; D005682:Gadolinium
keywords: ball-milling; doxorubicin; drug delivery; metal-organic frameworks; nanocarriers