title: Single-institution Experience of SBRT for Lung Metastases in Sarcoma Patients.
abstract: Lung metastasectomy is regarded as the standard procedure for improving the prognosis of patients with metastatic sarcoma. Few reports are available in the literature describing the value of stereotactic body radiation therapy (SBRT) of lung metastases from primary sarcoma as an alternative to surgical treatment. We therefore sought to expand the evidence base for this modality.
  
  
  
  Twenty-two patients with metastatic sarcoma to lung were treated by SBRT. The retrospective analysis of overall survival, toxicity, and local control of 53 treated lesions is presented in the study. Lung lesions were grouped into 2 categories for follow-up: <10 mm or ≥10 mm diameter.
  
  
  
  Of 34 lesions <10 mm, 24 achieved complete response, 3 partial response, and 7 stable disease. The results of 18 lesions measuring >10 mm were as follows: 5 complete response, 5 progressive disease, and 8 stable disease. No progressive disease of all SBRT treated lesions was found at a median follow-up of 95 months (SD 32). Five-year overall survival of the entire group was 62% from the time of diagnosis and 50% from start of treatment. The treatment was well tolerated with minimal, mainly skin toxicity.
  
  
  
  SBRT is an effective tool that might be used as an alternative to operative treatment of lung metastases in sarcoma patients.
authors.affiliation: Tel Aviv Medical Center, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Viacheslav
authors.initials: V
authors.lastname: Soyfer
authors.forename: Benjamin W
authors.initials: BW
authors.lastname: Corn
authors.forename: Natan
authors.initials: N
authors.lastname: Shtraus
authors.forename: Nir
authors.initials: N
authors.lastname: Honig
authors.forename: Yaron
authors.initials: Y
authors.lastname: Meir
authors.forename: Jehuda
authors.initials: J
authors.lastname: Kollender
authors.forename: Ofer
authors.initials: O
authors.lastname: Merimsky
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy* / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery; D012189:Retrospective Studies; D012509:Sarcoma / Q000532:radiotherapy* / Q000556:secondary*