title: Cecropin suppresses human hepatocellular carcinoma BEL- 7402 cell growth and survival in vivo without side-toxicity.
abstract: Conventional chemotherapy against hepatocellular carcinoma typically causes various side effects. Our previous study showed that cecropin of Musca domestica can induce apoptosis in human hepatocellular carcinoma BEL-7402 cells in vitro. However, whether cecropin inhibits BEL-7402 cell in vivo and the question of possible side effects remained undentified. The present study confirmed tumor-inhibitory effects of cecropin in vivo, and furthermore strongly suggested that cecropin cytotoxicity in BEL-7402 cells in vivo may be mainly derived from its pro-apoptotic action. Specifically, we found that cecropin exerted no obvious side effects in tumor-bearing mice as it had no significant hematoxicity as well as visceral toxicity. Therefore, cecropin may be a potential candidate for further investigation as an antitumor agent against hepatocellular carcinoma.
authors.affiliation: School of Basic Courses, Guangdong Pharmaceutical University, Guangzhou, China E-mail : zhujy@gdpu.edu.cn.
authors.forename: Xiao-Bao
authors.initials: XB
authors.lastname: Jin
authors.forename: Ying-Jiao
authors.initials: YJ
authors.lastname: Wang
authors.forename: Lu-Lu
authors.initials: LL
authors.lastname: Liang
authors.forename: Qiao-Hong
authors.initials: QH
authors.lastname: Pu
authors.forename: Juan
authors.initials: J
authors.lastname: Shen
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Lu
authors.forename: Fu-Jiang
authors.initials: FJ
authors.lastname: Chu
authors.forename: Jia-Yong
authors.initials: JY
authors.lastname: Zhu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D019556:COS Cells; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy*; D054807:Cecropins / Q000494:pharmacology*; D002460:Cell Line; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002522:Chlorocebus aethiops; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy*; D051379:Mice; D008819:Mice, Nude
chemical_list: D000970:Antineoplastic Agents; D054807:Cecropins