title: 2-Pyridonate tantalum complexes for the intermolecular hydroaminoalkylation of sterically demanding alkenes.
abstract: The design and synthesis of a mixed 2-pyridonate-Ta(NMe2)3Cl complex for the direct C-H alkylation adjacent to nitrogen in unprotected secondary amines are reported. The hydroaminoalkylation of sterically demanding internal alkenes gives the direct, catalytic formation of C(sp(3))-C(sp(3)) bonds. Substrate scope investigations reveal key strategies for further catalyst development efforts in this 100% atom-economic synthesis of α-alkylated amines.
authors.affiliation: Department of Chemistry, University of British Columbia , 2036 Main Mall, Vancouver, British Columbia, Canada V6T 1Z1.
authors.forename: Eugene
authors.initials: E
authors.lastname: Chong
authors.forename: Jason W
authors.initials: JW
authors.lastname: Brandt
authors.forename: Laurel L
authors.initials: LL
authors.lastname: Schafer