title: ω-3 polyunsaturated fatty acids-derived lipid metabolites on angiogenesis, inflammation and cancer.
abstract: Epidemiological and pre-clinical studies support the anti-tumor effects of ω-3 PUFAs; however, the results from human trials are mixed, making it difficult to provide dietary guidelines or recommendations of ω-3 PUFAs for disease prevention or treatment. Understanding the molecular mechanisms by which ω-3 PUFAs inhibit cancer could lead to better nutritional paradigms and human trials to clarify their health effects. The ω-3 PUFAs exert their biological activities mainly through the formation of bioactive lipid metabolites. Here we discuss the biology of cyclooxygenase, lipoxygenase and cytochrome P450 enzymes-derived ω-3-series lipid metabolites on angiogenesis, inflammation and cancer.
authors.affiliation: Department of Food Science, University of Massachusetts-Amherst, Amherst, MA 01003, United States.
authors.forename: Weicang
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Food Science, University of Massachusetts-Amherst, Amherst, MA 01003, United States.
authors.forename: Julia
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Food Science, University of Massachusetts-Amherst, Amherst, MA 01003, United States.
authors.forename: Fei
authors.initials: F
authors.lastname: Lyu
authors.affiliation: Center for Vascular Biology Research and Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, United States.
authors.forename: Dipak
authors.initials: D
authors.lastname: Panigrahy
authors.affiliation: Department of Biomedical Engineering, University of California, Davis, CA 95616, United States.
authors.forename: Katherine W
authors.initials: KW
authors.lastname: Ferrara
authors.affiliation: Department of Entomology and Comprehensive Cancer Center, University of California, Davis, CA 95616, United States. Electronic address: bdhammock@ucdavis.edu.
authors.forename: Bruce
authors.initials: B
authors.lastname: Hammock
authors.affiliation: Department of Food Science, University of Massachusetts-Amherst, Amherst, MA 01003, United States. Electronic address: guodongzhang@umass.edu.
authors.forename: Guodong
authors.initials: G
authors.lastname: Zhang
mesh_terms: D000818:Animals; D003580:Cytochromes / Q000378:metabolism; D015525:Fatty Acids, Omega-3 / Q000378:metabolism*; D043371:Fatty Acids, Omega-6 / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000201:enzymology / Q000378:metabolism*; D050356:Lipid Metabolism; D058945:Lipoxygenases / Q000378:metabolism; D009369:Neoplasms / Q000098:blood supply / Q000201:enzymology / Q000378:metabolism*; D009389:Neovascularization, Pathologic / Q000201:enzymology / Q000378:metabolism; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism
chemical_list: D003580:Cytochromes; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D058945:Lipoxygenases; D011451:Prostaglandin-Endoperoxide Synthases
keywords: Cyclooxygenase; Cytochrome P450; Lipoxygenase; ω-3 polyunsaturated fatty acids