title: Proliferative and non-proliferative lesions of the rat and mouse integument.
abstract: The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) project is a joint initiative of the societies of toxicological pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP). Its aim is to develop an internationally-accepted nomenclature for proliferative and non-proliferative lesions in laboratory rodents. A widely accepted international harmonization of nomenclature in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and will provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists. The purpose of this publication is to provide a standardized nomenclature for classifying microscopical lesions observed in the integument of laboratory rats and mice. Example colour images are provided for most lesions. The standardized nomenclature presented in this document and additional colour images are also available electronically at http://www.goreni.org. The nomenclature presented herein is based on histopathology databases from government, academia, and industrial laboratories throughout the world, and covers lesions that develop spontaneously as well as those induced by exposure to various test materials. (DOI: 10.1293/tox.26.27S; J Toxicol Pathol 2013; 26: 27S-57S).
authors.affiliation: mecklenburg-consulting, Hamburg, Germany.
authors.forename: Lars
authors.initials: L
authors.lastname: Mecklenburg
authors.affiliation: UT MD Anderson Cancer Center, Smithville, Texas, USA.
authors.forename: Donna
authors.initials: D
authors.lastname: Kusewitt
authors.affiliation: Novartis Pharma AG, Basel, Switzerland.
authors.forename: Carine
authors.initials: C
authors.lastname: Kolly
authors.affiliation: BASF SE, Ludwigshafen, Germany.
authors.forename: Silke
authors.initials: S
authors.lastname: Treumann
authors.affiliation: Experimental Pathology Laboratories, Inc, Research Triangle Park, North Carolina, USA.
authors.forename: E Terence
authors.initials: ET
authors.lastname: Adams
authors.affiliation: Hoffmann La-Roche Nonclinical Safety, Nutley, New Jersey, USA.
authors.forename: Kelly
authors.initials: K
authors.lastname: Diegel
authors.affiliation: Osaka Prefecture University, Osaka, Japan.
authors.forename: Jyoji
authors.initials: J
authors.lastname: Yamate
authors.affiliation: Merck Serono Research & Development, Darmstadt, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Kaufmann
authors.affiliation: Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany.
authors.forename: Susanne
authors.initials: S
authors.lastname: Müller
authors.affiliation: Genentech, South San Francisco, California, USA.
authors.forename: Dimitry
authors.initials: D
authors.lastname: Danilenko
authors.affiliation: Charles River, Tranent, Edinburgh, UK.
authors.forename: Alys
authors.initials: A
authors.lastname: Bradley
keywords: diagnostic pathology; histopathology; integumentary system; nomenclature; rodent pathology; skin; rodent