title: Coffee components and cardiovascular risk: beneficial and detrimental effects.
abstract: Coffee consists of several biological active compounds, such as caffeine, diterpenes, chlorogenic acids, and melanoidins, which may affect human health. The intake of each compound depends on the variety of coffee species, roasting degree, type of brewing method and serving size. The bioavailability and the distribution of each compound and its metabolites also contribute to coffee mechanisms of action. The health benefits of coffee consumption regarding cardiovascular system and metabolism mostly depend on its antioxidant compounds. In contrast, diterpenes and caffeine may produce harmful effects by raising lipid fraction and affecting endothelial function, respectively. Studying the mechanism of action of coffee components may help understanding whether coffee's impact on health is beneficial or hazardous. In this article, we reviewed the available information about coffee compounds and their mechanism of action. Furthermore, benefits and risks for cardiovascular system associated with coffee consumption will be discussed.
authors.affiliation: Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University , Krakow , Poland .
authors.forename: Justyna
authors.initials: J
authors.lastname: Godos
authors.forename: Francesca Romana
authors.initials: FR
authors.lastname: Pluchinotta
authors.forename: Stefano
authors.initials: S
authors.lastname: Marventano
authors.forename: Silvio
authors.initials: S
authors.lastname: Buscemi
authors.forename: Giovanni
authors.initials: G
authors.lastname: Li Volti
authors.forename: Fabio
authors.initials: F
authors.lastname: Galvano
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Grosso
mesh_terms: D000470:Alkaloids / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D002110:Caffeine / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000517:prevention & control; D002319:Cardiovascular System / Q000187:drug effects*; D002726:Chlorogenic Acid / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D003069:Coffee / Q000009:adverse effects / Q000737:chemistry*; D003924:Diabetes Mellitus, Type 2 / Q000517:prevention & control; D004224:Diterpenes / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D010936:Plant Extracts / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D011108:Polymers / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D059808:Polyphenols / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000470:Alkaloids; D003069:Coffee; D004224:Diterpenes; D010936:Plant Extracts; D011108:Polymers; D059808:Polyphenols; C011908:melanoidin polymers; D002726:Chlorogenic Acid; D002110:Caffeine; C009560:trigonelline
keywords: Antioxidant; caffeine; cardiovascular disease; nutrients; polyphenols