title: Stress-responsive regulation of mitochondria through the ER unfolded protein response.
abstract: The endoplasmic reticulum (ER) and mitochondria form physical interactions involved in the regulation of biologic functions including mitochondrial bioenergetics and apoptotic signaling. To coordinate these functions during stress, cells must coregulate ER and mitochondria through stress-responsive signaling pathways such as the ER unfolded protein response (UPR). Although the UPR is traditionally viewed as a signaling pathway responsible for regulating ER proteostasis, it is becoming increasingly clear that the protein kinase RNA (PKR)-like endoplasmic reticulum kinase (PERK) signaling pathway within the UPR can also regulate mitochondria proteostasis and function in response to pathologic insults that induce ER stress. Here, we discuss the contributions of PERK in coordinating ER-mitochondrial activities and describe the mechanisms by which PERK adapts mitochondrial proteostasis and function in response to ER stress.
authors.affiliation: Department of Molecular and Experimental Medicine, Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
authors.forename: T Kelly
authors.initials: TK
authors.lastname: Rainbolt
authors.affiliation: Department of Molecular and Experimental Medicine, Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
authors.forename: Jaclyn M
authors.initials: JM
authors.lastname: Saunders
authors.affiliation: Department of Molecular and Experimental Medicine, Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: wiseman@scripps.edu.
authors.forename: R Luke
authors.initials: RL
authors.lastname: Wiseman
mesh_terms: D000818:Animals; D059865:Endoplasmic Reticulum Stress / Q000502:physiology*; D006801:Humans; D008928:Mitochondria / Q000502:physiology*; D058767:Protein Unfolding; D015398:Signal Transduction / Q000502:physiology; D056811:Unfolded Protein Response / Q000502:physiology*
keywords: PERK; eIF2α phosphorylation; mitochondrial proteostasis; mitochondrial quality control; unfolded protein response (UPR)