title: OPN sesame.
abstract: Osteopontin (OPN) is a growth regulatory protein for hepatocellular carcinoma (HCC) and a potent chemoattractant for macrophages. Zhu and colleagues recently reported significant clinical associations between poor postoperative prognosis and the concurrent detection of tumoral OPN expression and peritumoral macrophage (PTM) infiltration. An in-depth understanding on the complex interaction between tumoral OPN and macrophage-infiltrated microenvironment opens new doors to novel anticancer treatments.
authors.affiliation: 1 Liver Research Center, Chang Gung Memorial Hospital, Taipei, Taiwan ; 2 Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Kung-Hao
authors.initials: KH
authors.lastname: Liang
authors.affiliation: 1 Liver Research Center, Chang Gung Memorial Hospital, Taipei, Taiwan ; 2 Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Chau-Ting
authors.initials: CT
authors.lastname: Yeh
keywords: Metastasis; cancer recurrence; early detection; inflammation