title: Two new cases of KIR3DP1, KIR2DL4-negative genotypes, one of which is also lacking KIR3DL2.
abstract: The killer immunoglobulin-like receptor (KIR) genes KIR2DL4, KIR3DL2, and KIR3DP1 are present in virtually all humans. KIR2DL4 encodes a receptor present on uterine and decidual natural killer (NK) cells and some peripheral blood NK cells. Its only known ligand is the human leukocyte antigen-G molecule expressed on extravillous trophoblasts, and on tissues in some diseases. KIR3DL2 binds HLA-A*03 and HLA-A*11 as well as HLA-B*27 dimers, and microbial CpG DNA. KIR3DP1 is a pseudogene. During our immunogenetic studies we found two individuals, one from Lower Silesia district in Poland, and another from Western Ukraine, who were reproducibly negative for KIR2DL4 and KIR3DP1 genes, using three different PCR systems. Both individuals displayed very similar genotypes, possessing only KIR3DL3, KIR2DL3, KIR2DP1, KIR2DS1, and probably a rare variant of KIR2DL1. The Pole had also KIR3DL2, which the Ukrainian was apparently lacking. The Lower Silesia has been populated after the Second World War by a remarkable percentage with displaced people from Western Ukraine, which might contribute to genetic similarity of the two individuals described here.
authors.affiliation: Laboratory of Immunogenetics and Tissue Immunology, Department of Clinical Immunology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114, Wrocław, Poland.
authors.forename: Wanda
authors.initials: W
authors.lastname: Niepiekło-Miniewska
authors.forename: Natalia
authors.initials: N
authors.lastname: Zuk
authors.forename: Joanna
authors.initials: J
authors.lastname: Dubis
authors.forename: Maciej
authors.initials: M
authors.lastname: Kurpisz
authors.forename: David
authors.initials: D
authors.lastname: Senitzer
authors.forename: Anna
authors.initials: A
authors.lastname: Havrylyuk
authors.forename: Ryszard
authors.initials: R
authors.lastname: Grendziak
authors.forename: Wojciech
authors.initials: W
authors.lastname: Witkiewicz
authors.forename: Valentyna
authors.initials: V
authors.lastname: Chopyak
authors.forename: Piotr
authors.initials: P
authors.lastname: Kuśnierczyk
mesh_terms: D000368:Aged; D003602:Cytotoxicity, Immunologic / Q000235:genetics; D005828:Genetics, Population; D005838:Genotype; D015234:HLA-A Antigens / Q000378:metabolism; D015791:HLA-A3 Antigen / Q000378:metabolism; D015796:HLA-B27 Antigen / Q000378:metabolism; D059951:HLA-G Antigens / Q000378:metabolism; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008297:Male; D011044:Poland; D011110:Polymorphism, Genetic; D011485:Protein Binding; D011544:Pseudogenes / Q000235:genetics; D054340:Receptors, KIR / Q000235:genetics; D054345:Receptors, KIR2DL4 / Q000235:genetics / Q000378:metabolism*; D054347:Receptors, KIR3DL2 / Q000235:genetics / Q000378:metabolism*; D014455:Ukraine; D055815:Young Adult
chemical_list: D015234:HLA-A Antigens; C487960:HLA-A*03 antigen; D015791:HLA-A3 Antigen; D015796:HLA-B27 Antigen; D059951:HLA-G Antigens; C515079:KIR2DL4 protein, human; C515084:KIR3DL2 protein, human; D054340:Receptors, KIR; D054345:Receptors, KIR2DL4; D054347:Receptors, KIR3DL2