title: Epigenetics in extracellular matrix remodeling and hyaluronan metabolism.
abstract: Cell behavior is determined by both genetic and environmental factors. The cell microenvironment is not only a scene in which various actors play a role, but is itself an active participant, able to influence many cellular responses by binding signaling molecules or by modulating intracellular signaling cascades. Further, extracellular matrix remodeling is a critical step to allow physiological as well as pathological processes. As environmental factors are able to modulate gene expression by epigenetic modifications, this review focuses on new aspects of the regulation of extracellular matrix remodeling enzymes. Moreover, as one of the main components of cell microenvironment is the glycosaminoglycan hyaluronan, novel findings regarding the control of hyaluronan synthesis are discussed in terms of epigenetics and from the post-translational point of view.
authors.affiliation: Department of Surgical and Morphological Sciences, University of Insubria, Varese, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Vigetti
authors.forename: Manuela
authors.initials: M
authors.lastname: Viola
authors.forename: Evgenia
authors.initials: E
authors.lastname: Karousou
authors.forename: Sara
authors.initials: S
authors.lastname: Deleonibus
authors.forename: Konstantina
authors.initials: K
authors.lastname: Karamanou
authors.forename: Giancarlo
authors.initials: G
authors.lastname: De Luca
authors.forename: Alberto
authors.initials: A
authors.lastname: Passi
mesh_terms: D000818:Animals; D003920:Diabetes Mellitus / Q000378:metabolism / Q000473:pathology; D044127:Epigenesis, Genetic; D005109:Extracellular Matrix / Q000235:genetics / Q000378:metabolism*; D014453:Glucuronosyltransferase / Q000378:metabolism; D006657:Histones / Q000378:metabolism; D006801:Humans; D000076002:Hyaluronan Synthases; D006820:Hyaluronic Acid / Q000235:genetics / Q000378:metabolism*; D035683:MicroRNAs / Q000502:physiology; D011499:Protein Processing, Post-Translational
chemical_list: D006657:Histones; D035683:MicroRNAs; D006820:Hyaluronic Acid; D014453:Glucuronosyltransferase; C101754:HAS2 protein, human; D000076002:Hyaluronan Synthases
keywords: O-GlcNAcylation; cell microenvironment; glycosaminoglycans; histone modifications; mRNA; matrix metalloproteinases; natural antisense transcript; proteoglycans; sirtuin