title: Intermolecular Interactions between Eosin Y and Caffeine Using1H-NMR Spectroscopy.
abstract: DETECHIP has been used in testing analytes including caffeine, cocaine, and tetrahydrocannabinol (THC) from marijuana, as well as date rape and club drugs such as flunitrazepam, gamma-hydroxybutyric acid (GHB), and methamphetamine. This study investigates the intermolecular interaction between DETECHIP sensor eosin Y (DC1) and the analyte (caffeine) that is responsible for the fluorescence and color changes observed in the actual array. Using1H-NMR,1H-COSY, and1H-DOSY NMR methods, a proton exchange from C-8 of caffeine to eosin Y is proposed.
authors.affiliation: Department of Chemistry, Doane College, 1014 Boswell Avenue, Crete, NE 68333, USA.
authors.forename: Macduff O
authors.initials: MO
authors.lastname: Okuom
authors.affiliation: Department of Chemistry, Doane College, 1014 Boswell Avenue, Crete, NE 68333, USA.
authors.forename: Mark V
authors.initials: MV
authors.lastname: Wilson
authors.affiliation: Department of Chemistry, Doane College, 1014 Boswell Avenue, Crete, NE 68333, USA.
authors.forename: Abby
authors.initials: A
authors.lastname: Jackson
authors.affiliation: Department of Chemistry, Doane College, 1014 Boswell Avenue, Crete, NE 68333, USA.
authors.forename: Andrea E
authors.initials: AE
authors.lastname: Holmes