title: An update on juvenile dermatomyositis.
abstract: Juvenile dermatomyositis (JDM) is a rare, severe, autoimmune disease characterized by a small-vessel vasculopathy that primarily affects skin and muscle, but also lung, joints, gut and heart. Nowadays prompt recognition of this entity and aggressive treatment, when needed, improves outcomes and has decreased mortality that, before corticosteroid became a mainstay in therapy, could reach 40%.
authors.affiliation: Clinica Dermatologica Università degli Studi di Parma, Parma, Italia - claudio.feliciani@unipr.it.
authors.forename: V
authors.initials: V
authors.lastname: Boccaletti
authors.forename: S
authors.initials: S
authors.lastname: Di Nuzzo
authors.forename: C
authors.initials: C
authors.lastname: Feliciani
authors.forename: G
authors.initials: G
authors.lastname: Fabrizi
authors.forename: C
authors.initials: C
authors.lastname: Pagliarello
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use; D001284:Atrophy; D001323:Autoantibodies / Q000276:immunology; D002196:Capillaries / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000378:metabolism; D003713:Dendritic Cells / Q000378:metabolism / Q000473:pathology; D003882:Dermatomyositis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D018450:Disease Progression; D042241:Early Diagnosis; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D000069285:Infliximab; D000069283:Rituximab; D012867:Skin / Q000098:blood supply / Q000473:pathology
chemical_list: D000305:Adrenal Cortex Hormones; D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D001323:Autoantibodies; D016207:Cytokines; D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents; D000069283:Rituximab; D000069285:Infliximab