title: Skin barrier and immune dysregulation in atopic dermatitis: an evolving story with important clinical implications.
abstract: Atopic dermatitis is the most common chronic inflammatory skin disease. Its pathogenesis combines barrier defects, immune dysregulation, and increased skin infections; however, the relative contribution of each of these components is yet to be determined. Uninvolved atopic dermatitis skin also displays broad immune and barrier abnormalities, which highlights a role for proactive treatment strategy. The residual disease genomic profile that accompanies clinical resolution provides further support for proactive treatment approaches. Although intrinsic and extrinsic atopic dermatitis subtypes share a common clinical phenotype, they show some important differences in their Th22/Th17 cytokine profile, which opens the door for personalized specific therapeutics for each disease category.
authors.affiliation: The Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY; Center for Clinical and Translational Science, The Rockefeller University, New York, NY.
authors.forename: Tali
authors.initials: T
authors.lastname: Czarnowicki
authors.affiliation: The Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY; Center for Clinical and Translational Science, The Rockefeller University, New York, NY.
authors.forename: James G
authors.initials: JG
authors.lastname: Krueger
authors.affiliation: The Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY; Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address: eguttman@rockefeller.edu.
authors.forename: Emma
authors.initials: E
authors.lastname: Guttman-Yassky
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism; D003876:Dermatitis, Atopic / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D006706:Homeostasis; D006801:Humans; D007109:Immunity; D057285:Precision Medicine; D012867:Skin / Q000473:pathology*; D058408:Th1-Th2 Balance; D058504:Th17 Cells / Q000276:immunology*
chemical_list: D016207:Cytokines
keywords: Atopic dermatitis; Extrinsic atopic dermatitis; Immune dysregulation; Intrinsic atopic dermatitis; Microbiome; Proactive treatment; Residual disease genomic profile; Skin barrier