title: In vitro and in vivo studies on adlay-derived seed extracts: phenolic profiles, antioxidant activities, serum uric acid suppression, and xanthine oxidase inhibitory effects.
abstract: This study aimed to explore the potential of polished adlay, brown adlay, adlay bran, and adlay hull to prevent and treat hyperuricemia. Brown adlay extract effectively decreased the serum uric acid levels of oxonate-induced hyperuricemic rats. Free and bound phenolic extracts from these materials contained significant amounts of phenolics, with free phenolics dominated by chlorogenic acid and p-coumaric acid while bound phenolics dominated by p-coumaric acid and ferulic acid. Free and bound phenolics of adlay bran exhibited significant xanthine oxidase inhibition activities, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activities, oxygen radical absorbance capacities, and superoxide radical scavenging activities. Adlay bran phenolics could be effective xanthine oxidase inhibitors and radical scavengers. p-Coumaric acid is a xanthine oxidase inhibitor with strong superoxide radical scavenging activity. However, ferulic acid is a xanthine oxidase inhibitor with weak superoxide radical scavenging activity. Chlorogenic acid is a superoxide radical scavenger with weak xanthine oxidase inhibitory activity.
authors.affiliation: College of Light Industry and Food Sciences, South China University of Technology , Guangzhou 510640, China.
authors.forename: Mouming
authors.initials: M
authors.lastname: Zhao
authors.forename: Dashuai
authors.initials: D
authors.lastname: Zhu
authors.forename: Dongxiao
authors.initials: D
authors.lastname: Sun-Waterhouse
authors.forename: Guowan
authors.initials: G
authors.lastname: Su
authors.forename: Lianzhu
authors.initials: L
authors.lastname: Lin
authors.forename: Xiao
authors.initials: X
authors.lastname: Wang
authors.forename: Yi
authors.initials: Y
authors.lastname: Dong
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002726:Chlorogenic Acid / Q000494:pharmacology; D031742:Coix / Q000737:chemistry*; D003373:Coumaric Acids / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000494:pharmacology; D033461:Hyperuricemia / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control*; D008297:Male; D010094:Oxonic Acid; D010636:Phenols / Q000032:analysis*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D011422:Propionates; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds / Q000737:chemistry; D014527:Uric Acid / Q000097:blood; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors*
chemical_list: D000975:Antioxidants; D003373:Coumaric Acids; D004791:Enzyme Inhibitors; D016166:Free Radical Scavengers; D010636:Phenols; D010936:Plant Extracts; D011422:Propionates; D014527:Uric Acid; D002726:Chlorogenic Acid; D010094:Oxonic Acid; C004999:ferulic acid; D014969:Xanthine Oxidase; C495469:p-coumaric acid