title: Clinical significance of non-alcoholic fatty liver disease as a risk factor for prehypertension.
abstract: Previous epidemiologic studies have shown the clinical association between non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD). However, there is only limited information about the effect of NAFLD on the development of hypertension. Accordingly, we investigated the clinical association between NAFLD and prehypertension. A prospective cohort study was conducted on the 11,350 Korean men without prehypertension for 5 yr. The incidences of prehypertension were evaluated, and Cox proportional hazard model was used to measure the hazard ratios (HRs) for the development of prehypertension according to the degree of NAFLD (normal, mild, moderate to severe). The incidence of prehypertension increased according to NAFLD states (normal: 55.5%, mild: 63.7%, moderate to severe: 70.3%, P<0.001). Even after adjusting for multiple covariates, the HRs (95% confidence interval) for prehypertension were higher in the mild group (1.18; 1.07-1.31) and moderate to severe group (1.62; 1.21-2.17), compared to normal group, respectively (P for trend <0.001). The development of prehypertension is more potentially associated with the more progressive NAFLD than normal and milder state. These findings suggest the clinical significance of NAFLD as one of risk factors for prehypertension.
authors.affiliation: Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Korea. ; Department of Occupational and Environmental Medicine, Bucheon Daesung Hospital, Bucheon, Korea.
authors.forename: Jae-Hong
authors.identifier: 0000-0002-5232-1426
authors.initials: JH
authors.lastname: Ryoo
authors.affiliation: Department of Physical Education, Graduate School, Sangji University, Wonju, Korea.
authors.forename: Woo Taek
authors.identifier: 0000-0003-3212-1627
authors.initials: WT
authors.lastname: Ham
authors.affiliation: Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Joong-Myung
authors.identifier: 0000-0002-3610-6662
authors.initials: JM
authors.lastname: Choi
authors.affiliation: Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Min A
authors.identifier: 0000-0003-1889-8122
authors.initials: MA
authors.lastname: Kang
authors.affiliation: Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: So Hee
authors.identifier: 0000-0002-8436-7402
authors.initials: SH
authors.lastname: An
authors.affiliation: Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Jong-Keun
authors.identifier: 0000-0003-1376-3202
authors.initials: JK
authors.lastname: Lee
authors.affiliation: Department of Family Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Korea.
authors.forename: Ho Cheol
authors.identifier: 0000-0003-0212-1917
authors.initials: HC
authors.lastname: Shin
authors.affiliation: Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Korea. ; Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Korea.
authors.forename: Sung Keun
authors.identifier: 0000-0003-4703-9917
authors.initials: SK
authors.lastname: Park
mesh_terms: D000328:Adult; D001786:Blood Glucose; D001794:Blood Pressure; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000175:diagnosis; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000150:complications / Q000175:diagnosis*; D058246:Prehypertension / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D012907:Smoking
chemical_list: D001786:Blood Glucose
keywords: Blood Pressure; Non-Alcoholic Fatty Liver Disease; Prehypertension