title: The effect of periodontal therapy on cardiovascular risk markers: a 6-month randomized clinical trial.
abstract: OBJECTIVE
  To determine the influence of non-surgical mechanical periodontal treatment on inflammatory markers related to risk for cardiovascular disease.
  
  
  METHODS
  A total of 64 patients with severe chronic periodontitis was randomly subjected to immediately periodontal treatment (test group, n = 32) or delayed periodontal treatment, without treatment during the study period (control group, n = 32). Clinical periodontal and laboratory examinations were performed at baseline (T0), 2 months (T2), and 6 months (T6) after the initial examinations (Control group) or completion of periodontal treatment (Test group).
  
  
  RESULTS
  After 2 months of periodontal treatment there was a significant reduction of erythrocyte sedimentation rate (ESR) and triglycerides (p = 0.002, p = 0.004, respectively) in the test group. Median values of C-reactive protein, ESR, total cholesterol, and triglycerides were reduced after 6 month of periodontal treatment in the test group (p < 0.001, p < 0.001, p < 0.001, and p = 0.015, respectively).
  
  
  CONCLUSIONS
  The non-surgical periodontal treatment was effective in reducing the levels of systemic inflammation markers and improved the lipid profile in subjects with severe chronic periodontitis.
authors.affiliation: Department of Periodontology, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro, Brazil.
authors.forename: André Luis
authors.initials: AL
authors.lastname: Caúla
authors.forename: Ronaldo
authors.initials: R
authors.lastname: Lira-Junior
authors.forename: Eduardo Muniz Barretto
authors.initials: EM
authors.lastname: Tinoco
authors.forename: Ricardo Guimarães
authors.initials: RG
authors.lastname: Fischer
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001799:Blood Sedimentation; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D055113:Chronic Periodontitis / Q000628:therapy*; D003774:Dental Plaque Index; D048909:Diabetes Complications; D004522:Educational Status; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000145:classification / Q000628:therapy; D057747:Periodontal Debridement / Q000379:methods*; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000145:classification / Q000628:therapy; D012307:Risk Factors; D012907:Smoking; D014280:Triglycerides / Q000097:blood
chemical_list: D015415:Biomarkers; D014280:Triglycerides; D002097:C-Reactive Protein; D002784:Cholesterol
keywords: C-reactive protein; cardiovascular disease; erythrocyte sedimentation rate; periodontitis; triglycerides