title: Possible mechanism and clinical potentials of allostery.
abstract: Allostery is involved in the dynamic regulation of biological functions in proteins. Advances in allostery research have recently drawn great interest and brought allostery closer to the clinic. The present commentary describes the mechanism by which allostery may involve in from a cell-wide view and its contribution to the discovery of new therapeutics to diseases.
authors.affiliation: Liver Cancer Institute, Pulmonary Department, Fudan University Zhongshan Hospital, Shanghai 200032, China.
authors.forename: Peixin
authors.initials: P
authors.lastname: Huang
authors.affiliation: Department of Oncohematology of Children, Hospital Universitario Niño Jesús, Avda. Menéndez Pelayo, NO 65, 28009 Madrid, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: López Villar
keywords: Allostery; DNA; Disease; Drug