title: Buschke-Löwenstein tumor: squamous cell carcinoma of the anogenital region.
abstract: BACKGROUND
  Buschke-Löwenstein tumor (BLT), as a rare form of condylomata acuminatum, was firstly described by Buschke in 1886 as a "carcinoma-like condyloma acuminatum of the penis". BLT is generally considered to be a low-grade variant of squamous cell carcinoma of the anogenital region.
  
  
  METHODS
  We describe a case of BLT in a 56-year-old male patient who was referred to our institute due to a large defect in the gluteal region. The biopsy of the lesion was performed and the diagnosis of BLT was made on histopathological examination. Magnetic resonance imaging of the pelvis showed the extensive vegetant lesion that significantly infiltrated pelvic organs accompanied with an enlargement of para-iliac lymph nodes. Sygmoidostomy for fecal diversion was done and chemotherapy with 5-fluorouracil and cisplatin was initiated. Unfortunately, the patient's severe condition caused fatal outcome.
  
  
  CONCLUSIONS
  Our case points out that BLT should be treated at the initial stage in order to prevent untreatable condition which happened in our patient. Therefore, early diagnostics and staging of the disease using modern technologies are crucial in order to treat patients effectively.
authors.forename: Ivan
authors.initials: I
authors.lastname: Turkalj
authors.forename: Dragana
authors.initials: D
authors.lastname: Djilas-Ivanović
authors.forename: Nedeljka
authors.initials: N
authors.lastname: Boskov
authors.forename: Branislav
authors.initials: B
authors.lastname: Petrov
authors.forename: Laszlo
authors.initials: L
authors.lastname: Stajer
authors.forename: Tatjana
authors.initials: T
authors.lastname: Ivković-Kapicl
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001005:Anus Neoplasms / Q000188:drug therapy / Q000473:pathology*; D001706:Biopsy; D062688:Buschke-Lowenstein Tumor / Q000188:drug therapy / Q000473:pathology*; D002081:Buttocks / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000473:pathology; D002945:Cisplatin / Q000008:administration & dosage; D017809:Fatal Outcome; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D002945:Cisplatin; D005472:Fluorouracil