title: Comparing the effects of nebivolol and dexpanthenol on wound healing: an experimental study.
abstract: Wound healing is a dynamic, interactive process that is initiated in response to injury. A number of investigations and clinical studies have been performed to determine new approaches for the improvement of wound healing. The aim of this study was to compare the effects of dexpanthenol, a molecule that is widely used for improving wound healing, and nebivolol, a molecule that increases nitric oxide release, on wound healing. A total of 30 rats were divided into three equal groups (n = 10). A linear 2 cm incision was made in the rats' skin. No treatment was administered in the first (control) group. Dexpanthenol cream was administered to the rats in the second group and 5% nebivolol cream was administered to the rats in the third group. The wound areas of all of the rats were measured on certain days. On the 21(st) day, all wounds were excised and histologically evaluated. The wound healing rates of the dexpanthenol and nebivolol groups were higher than those of the control group (P < 0·05). However, the wound healing rates of the dexpanthenol and nebivolol groups were not significantly different. Nebivolol and dexpanthenol have comparable effects on wound healing.
authors.affiliation: Department of General Surgery, Dicle University Medical Faculty, Diyarbakır, Turkey.
authors.forename: Burak V
authors.initials: BV
authors.lastname: Ulger
authors.affiliation: Department of General Surgery, Dicle University Medical Faculty, Diyarbakır, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Kapan
authors.affiliation: Department of General Surgery, Dicle University Medical Faculty, Diyarbakır, Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Uslukaya
authors.affiliation: Department of General Surgery, Dicle University Medical Faculty, Diyarbakır, Turkey.
authors.forename: Zubeyir
authors.initials: Z
authors.lastname: Bozdag
authors.affiliation: Department of General Surgery, Dicle University Medical Faculty, Diyarbakır, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Turkoglu
authors.affiliation: Department of Pathology, Dicle University Medical Faculty, Diyarbakır, Turkey.
authors.forename: Ulas
authors.initials: U
authors.lastname: Alabalık
authors.affiliation: Department of General Surgery, Dicle University Medical Faculty, Diyarbakır, Turkey.
authors.forename: Akın
authors.initials: A
authors.lastname: Onder
mesh_terms: D000818:Animals; D000068577:Nebivolol; D010205:Pantothenic Acid / Q000031:analogs & derivatives; D051381:Rats; D012867:Skin; D014945:Wound Healing
chemical_list: D000068577:Nebivolol; D010205:Pantothenic Acid; C007288:dexpanthenol
keywords: Dexpanthenol; Nebivolol; Wound healing