title: Vanadium methyl-bipyridine organoligand and its influence on energy balance and organs mass.
abstract: In the treatment of lifestyle diseases, including metabolic syndrome and type 2 diabetes, it is important to lower body mass and fat tissue, and consequently, to increase insulin-sensitivity. Unfortunately, it often happens that low-energy diet which would lower overweight is not observed and, thus, it does not bring the expected effects. This paper discusses the influence of three diets-control, high-fructose, and high-fatty diet-on absorption of energy from food in order to transform it into body mass. The kJ/g ratio which describes this process has been calculated. In the tested diets, the addition of fructose (79.13 ± 2.47 kJ/g) or fat (82.48 ± 2.28 kJ/g) results in higher transformation of energy into body mass than in the case of control diet (89.60 ± 1.86 kJ/g). The addition of Na[VO(O2)2(4,4′-Me2-2,2′-bpy)]•8H2O (where 4,4′-Me2-2,2′-bpy = 4,4′-dimethyl-2,2′-bipyridine) results in statistical increase of that ratio: fructose diet (86.88 ± 0.44 kJ/g), fat diet (104.68 ± 3.01 kJ/g), and control diet (115.98 ± 0.56 kJ/g), respectively. Fat diet statistically influences the decrease of kidney mass in comparison to the other diets. The application of the tested vanadium compound results also in the statistical decrease of the fatty liver caused by fructose and fat diet.
authors.forename: Mirosław
authors.initials: M
authors.lastname: Krośniak
authors.forename: Renata
authors.initials: R
authors.lastname: Francik
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Wojtanowska-Krośniak
authors.forename: Cinzia
authors.initials: C
authors.lastname: Tedeschi
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Krasoń-Nowak
authors.forename: Joanna
authors.initials: J
authors.lastname: Chłopicka
authors.forename: Ryszard
authors.initials: R
authors.lastname: Gryboś
mesh_terms: D000818:Animals; D004040:Dietary Carbohydrates / Q000009:adverse effects* / Q000494:pharmacology; D004041:Dietary Fats / Q000009:adverse effects* / Q000494:pharmacology; D004734:Energy Metabolism / Q000187:drug effects*; D005234:Fatty Liver / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008297:Male; D009929:Organ Size; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014638:Vanadates / Q000494:pharmacology*
chemical_list: D004040:Dietary Carbohydrates; D004041:Dietary Fats; D011725:Pyridines; D014638:Vanadates