title: Activities of daily living, depression, and quality of life in Parkinson's disease.
abstract: This study examined whether activities of daily living (ADL) mediate the relationship between depression and health-related quality of life (HR-QOL) in people with Parkinson's disease (PD). A cross-sectional, correlational research design examined data from 174 participants who completed the Geriatric Depression Scale (GDS-15), Parkinson's Disease Questionnaire-39 (PDQ-39), and Unified Parkinson's Disease Rating Scale-section 2 (UPDRS-section 2 [ADL]). Multiple Regression Analysis (MRA) was used to examine the mediator model. Depression and ADL significantly (p<.001) predicted HR-QOL, and depression significantly (p<.001) predicted ADL. Whilst ADL did not impact on the relationship between depression and HR-QOL, there was a significant (p<.001) indirect effect of depression on HR-QOL via ADL, suggesting both direct and indirect (via ADL) effects of depression on HR-QOL. The magnitude of this effect was moderate (R2 = .13). People with PD who report depression also experience greater difficulty completing ADL, which impacts upon their HR-QOL. It is recommended that clinicians adopt a multidisciplinary approach to care by combining pharmacological treatments with psycho/occupational therapy, thereby alleviating the heterogeneous impact of motor and non-motor symptoms on HR-QOL in people with PD.
authors.affiliation: Curtin Neuroscience Laboratory, School of Psychology and Speech Pathology, Curtin University, Perth, Western Australia, Australia.
authors.forename: Blake J
authors.initials: BJ
authors.lastname: Lawrence
authors.affiliation: Curtin Neuroscience Laboratory, School of Psychology and Speech Pathology, Curtin University, Perth, Western Australia, Australia; Parkinson's Centre (ParkC), Curtin University, Perth, Western Australia, Australia.
authors.forename: Natalie
authors.initials: N
authors.lastname: Gasson
authors.affiliation: Curtin Neuroscience Laboratory, School of Psychology and Speech Pathology, Curtin University, Perth, Western Australia, Australia.
authors.forename: Robert
authors.initials: R
authors.lastname: Kane
authors.affiliation: Parkinson's Centre (ParkC), Curtin University, Perth, Western Australia, Australia; School of Psychology, University of Western Australia, Perth, Western Australia, Australia.
authors.forename: Romola S
authors.initials: RS
authors.lastname: Bucks
authors.affiliation: Curtin Neuroscience Laboratory, School of Psychology and Speech Pathology, Curtin University, Perth, Western Australia, Australia; Parkinson's Centre (ParkC), Curtin University, Perth, Western Australia, Australia.
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Loftus
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003863:Depression / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000503:physiopathology*; D011788:Quality of Life