title: Plasma cell mucositis with gingival enlargement and severe periodontitis.
abstract: Plasma cell mucositis (PCM) is a very rare, chronic, multifocal, idiopathic, non-neoplastic plasma cell proliferative disorder of the upper aerodigestive tract. The classic clinical presentation is an intensely erythematous mucosa with surface changes described variously as papillomatous, cobblestone, nodular or velvety. It is a very rare condition <50 cases reported in literature. A 72-year-old male patient complained of sore throat, stomatodynia, dysphagia, multiple oral ulcers, enlarged swollen bleeding gums and mobile teeth. There was chronic inflammatory enlargement of the gingiva and palate with severe periodontitis. Histopathological examination revealed a hyperplastic epithelium with a dense infiltrate of mature polyclonal plasma cells in the superficial layer of the lamina propria. PCM is a diagnosis of exclusion, to be differentiated from other infective, reactive, autoimmune, allergic and neoplastic disorders with plasma cell infiltrates. Management with surgical and immunosuppressive therapy is mostly ineffective with short remissions and frequent relapses.
authors.affiliation: Department of Oral Medicine and Radiology, Maulana Azad Institute of Dental Sciences, New Delhi, India.
authors.forename: Shalini R
authors.initials: SR
authors.lastname: Gupta
authors.affiliation: Department of Rheumatology and Clinical Immunology, Medanta Medicity, Gurgaon, Haryana, India.
authors.forename: Rajiva
authors.initials: R
authors.lastname: Gupta
authors.affiliation: Department of General Pathology, Govind Vallabh Pant Hospital, New Delhi, India.
authors.forename: Ravindra K
authors.initials: RK
authors.lastname: Saran
authors.affiliation: Department of Oral and Maxillofacial Surgery, Maulana Azad Institute of Dental Sciences, New Delhi, India.
authors.forename: Sriram
authors.initials: S
authors.lastname: Krishnan
keywords: Dysphagia; gingival enlargement; periodontitis; plasma cell mucositis; stomatodynia