title: An activatable, polarity dependent, dual-luminescent imaging agent with a long luminescence lifetime.
abstract: In this proof-of-concept study, a new activatable imaging agent based on two luminophores and two different quenching mechanisms is reported. Both partial and total activation of the luminescence signal can be achieved, either in solution or in vitro. Bond cleavage makes the compound suitable for luminescence lifetime imaging.
authors.affiliation: Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands. f.w.b.van_leeuwen@lumc.nl.
authors.forename: Marcus T M
authors.initials: MT
authors.lastname: Rood
authors.forename: Maria
authors.initials: M
authors.lastname: Oikonomou
authors.forename: Tessa
authors.initials: T
authors.lastname: Buckle
authors.forename: Marcel
authors.initials: M
authors.lastname: Raspe
authors.forename: Yasuteru
authors.initials: Y
authors.lastname: Urano
authors.forename: Kees
authors.initials: K
authors.lastname: Jalink
authors.forename: Aldrik H
authors.initials: AH
authors.lastname: Velders
authors.forename: Fijs W B
authors.initials: FW
authors.lastname: van Leeuwen
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000175:diagnosis; D002232:Carbocyanines / Q000737:chemistry*; D002460:Cell Line; D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000737:chemistry*; D005260:Female; D007495:Iridium / Q000737:chemistry*; D049449:Luminescence; D049408:Luminescent Agents / Q000737:chemistry*; D008163:Luminescent Measurements; D051379:Mice; D018613:Microscopy, Confocal; D009369:Neoplasms / Q000175:diagnosis; D061848:Optical Imaging
chemical_list: D002232:Carbocyanines; D056831:Coordination Complexes; D049408:Luminescent Agents; C085321:cyanine dye 5; D007495:Iridium