title: Prospective study of muscle cramps in Charcot-Marie-tooth disease.
abstract: BACKGROUND
  This study aims to assess the frequency, location, severity, duration, and fluctuation over time of muscle cramps in Charcot-Marie-Tooth disease (CMT).
  
  
  METHODS
  Inherited Neuropathies Consortium Contact Registry participants recorded the occurrence and characteristics of muscle cramps using an 11-question survey administered 3 times over 8 weeks.
  
  
  RESULTS
  A total of 110 adult patients with CMT completed the survey. Weekly cramp frequency was 9.3 (SD 12.3), and 23% had daily muscle cramps. Twenty-two percent reported a significant impact on quality of life. Over 8 weeks, the daily frequency and severity of muscle cramps did not change significantly.
  
  
  CONCLUSIONS
  Patients with CMT have muscle cramps that vary little over an 8-week period, and they may interfere with quality of life. These data may be useful in the planning of clinical trials of agents to treat adults with CMT-associated muscle cramps.
authors.affiliation: The University of Rochester Medical Center, Department of Neurology, Rochester, New York, USA.
authors.forename: Nicholas E
authors.initials: NE
authors.lastname: Johnson
authors.forename: Janet
authors.initials: J
authors.lastname: Sowden
authors.forename: Nuran
authors.initials: N
authors.lastname: Dilek
authors.forename: Katy
authors.initials: K
authors.lastname: Eichinger
authors.forename: Joshua
authors.initials: J
authors.lastname: Burns
authors.forename: Michael P
authors.initials: MP
authors.lastname: Mcdermott
authors.forename: Michael E
authors.initials: ME
authors.lastname: Shy
authors.forename: David N
authors.initials: DN
authors.lastname: Herrmann
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002607:Charcot-Marie-Tooth Disease / Q000150:complications / Q000503:physiopathology*; D003625:Data Collection; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009120:Muscle Cramp / Q000209:etiology / Q000503:physiopathology*; D011446:Prospective Studies; D011788:Quality of Life; D012720:Severity of Illness Index; D055815:Young Adult
keywords: CMT symptoms; Charcot-Marie-Tooth disease; RDCRN; Rare Disease Clinical Research Network; longitudinal survey; muscle cramps; quality of life