title: Postradiation changes in tissues: evaluation by imaging studies with emphasis on fluorodeoxyglucose-PET/computed tomography and correlation with histopathologic findings.
abstract: Efforts have been made to minimize the damage to adjacent normal tissues during radiotherapy, primarily by shifting from the use of conventional radiotherapy to more advanced techniques. Reviewing the overall pattern on combined anatomic and functional imaging can enhance diagnostic accuracy. Several radiotracers can be used; [(18)F]fluorodeoxyglucose is the most common. Familiarity with the type and timing of previous radiation therapy, the spectrum of imaging findings after radiation injury, and the appropriate use of the different radiotracers can be crucial. This article summarizes postradiation histologic findings and multimodality imaging findings, with emphasis on PET/computed tomography.
authors.affiliation: Department of Imaging, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
authors.forename: Liran
authors.initials: L
authors.lastname: Domachevsky
authors.affiliation: Department of Imaging, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
authors.forename: Heather A
authors.initials: HA
authors.lastname: Jacene
authors.affiliation: Department of Imaging, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Sakellis
authors.affiliation: Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. Electronic address: ckkim@bwh.harvard.edu.
authors.forename: Chun K
authors.initials: CK
authors.lastname: Kim
mesh_terms: D001842:Bone and Bones / Q000473:pathology / Q000528:radiation effects; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology / Q000528:radiation effects; D001932:Brain Neoplasms / Q000532:radiotherapy; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D041981:Gastrointestinal Tract / Q000473:pathology / Q000528:radiation effects; D006801:Humans; D008168:Lung / Q000473:pathology / Q000528:radiation effects; D008279:Magnetic Resonance Imaging; D064847:Multimodal Imaging; D009336:Necrosis / Q000000981:diagnostic imaging; D009369:Neoplasms / Q000532:radiotherapy; D011832:Radiation Injuries / Q000000981:diagnostic imaging* / Q000473:pathology; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D011878:Radiotherapy / Q000009:adverse effects; D013116:Spinal Cord / Q000473:pathology / Q000528:radiation effects; D014018:Tissue Distribution; D014057:Tomography, X-Ray Computed; D014551:Urinary Tract / Q000473:pathology / Q000528:radiation effects
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: Fluorodeoxyglucose; Positron emission tomography/computed tomography; Postradiation change; Radiation; Tissue necrosis; Tolerance dose