title: [Clinical effectiveness and safety of combined therapy with alpha-blocker and an anticholinergic drug for bladder outlet obstruction with overactive bladder: a Meta-analysis of outcomes].
abstract: OBJECTIVE
  To compare the clinical effectiveness and safety of alpha-blocker alone and combined tamsulosin with an anticholinergic drug for bladder outlet obstruction (BOO) with overactive bladder (OAB).
  
  
  METHODS
  Literature search was performed using PubMed, EMBASE, Ovid, Wanfang, and CNKI from inception to October 2013 for comparative studies assessing alpha-blocker alone and combined alpha-blocker with an anticholinergic drug for BOO+OAB. Data were extracted and evaluated by two reviewers independently according to the Cochrane Handbook for systematic reviews. Meta-analyses were conducted using RevMan 5.2.
  
  
  RESULTS
  A total of 7 studies involving 3 458 patients were included for the analysis. The values of total IPSS and storage IPSS reduced significantly after treatment in combination group (RR = -0.23, 95%CI: -0.44--0.02, P = 0.03; RR = -0.69, 95%CI: -0.88--0.51, P < 0.01). There were no significant differences between the two groups in voiding IPSS and Qmax (P = 0.86 and 0.89). The incidences of dry mouth (OR = 2.53), constipation (OR = 3.74), dizziness (OR = 0.73), and urinary retention (OR = 0.26) were higher in combination group than in alpha-blocker alone group (P < 0.05). But most adverse events were mild in degree.
  
  
  CONCLUSIONS
  Alpha-blocker combined with an anticholinergic drug in the treatment of BOO+OAB was better than that of alpha-blocker alone, and was safe and well tolerated.
authors.affiliation: Department of Urology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. Email: yszhou9510@163.com.
authors.forename: Bingqian
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of Urology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Urology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
authors.forename: Yikun
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Urology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
authors.forename: Yudong
authors.initials: Y
authors.lastname: Wu
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use*; D018680:Cholinergic Antagonists / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D013449:Sulfonamides / Q000627:therapeutic use*; D000077409:Tamsulosin; D016896:Treatment Outcome; D001748:Urinary Bladder Neck Obstruction / Q000188:drug therapy*; D053201:Urinary Bladder, Overactive / Q000188:drug therapy*
chemical_list: D000317:Adrenergic alpha-Antagonists; D018680:Cholinergic Antagonists; D013449:Sulfonamides; D000077409:Tamsulosin