title: Diagnostic and clinical implications of functional neuroimaging in bipolar disorder.
abstract: Advances in functional neuroimaging have ushered in studies that have enhanced our understanding of the neuropathophysiology of bipolar disorder, but do not yet have clinical applications. We describe the major circuits (ventrolateral, dorsolateral, ventromedial, and anterior cingulate) thought to be involved in the corticolimbic dysregulation that may underlie mood states in patients with bipolar disorder. The potential clinical application of functional neuroimaging in bipolar disorder is considered in terms of prognostic, predictive, and treatment biomarkers. To date, most research has focused on prognostic biomarkers to differentiate patients with bipolar disorder from those with other affective or psychotic diagnoses, or healthy subjects. The search for treatment biomarkers, which suggest mechanisms of pharmacodynamic or treatment response, and predictive biomarkers has thus far involved only pediatric patients diagnosed with bipolar disorder. The results to date are encouraging and suggest that functional neuroimaging may be of eventual benefit in determining biomarkers of treatment response. Further refinement of biomarker identification, and perhaps even illness characterization are needed to find prognostic and predictive biomarkers of bipolar disorder.
authors.affiliation: Department of Psychiatry & Biobehavioral Sciences, UCLA Semel Institute for Neuroscience & Human Behavior, Los Angeles, CA, USA. Electronic address: john.brooks@ucla.edu.
authors.forename: John O
authors.initials: JO
authors.lastname: Brooks
authors.affiliation: Department of Psychiatry & Biobehavioral Sciences, UCLA Semel Institute for Neuroscience & Human Behavior, Los Angeles, CA, USA.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Vizueta
mesh_terms: D000328:Adult; D000339:Affect; D015415:Biomarkers; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D059907:Functional Neuroimaging / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D011379:Prognosis; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers
keywords: Biomarkers; Bipolar disorder; Mood disorders; PET; Treatment; fMRI