title: Zinc-finger protein X-linked is a novel predictor of prognosis in patients with colorectal cancer.
abstract: Zinc-finger protein X-linked (ZFX) has been demonstrated to play an important role in the development of human malignancies. However, its prognostic significance in cancer patients remains unclear and less is known about its role in colorectal cancer (CRC). In this study, we found that the expression of ZFX in CRC tissues was significantly higher than that in corresponding normal tissues by quantitative real-time polymerase chain reaction and Western blot. Using immunohistochemistry, we explored the associations between protein expression of ZFX and clinicopathological parameters in 120 CRC cases. The results showed that ZFX expression was significantly associated with tumor differentiation (P = 0.022), tumor size (P = 0.037), tumor invasion (P = 0.027), lymph node metastasis (P = 0.042), distant metastasis (P = 0.011), and Dukes' classification (P = 0.028). Moreover, according to Kaplan-Meier model, patients with high expression of ZFX had a significantly poorer prognosis compared to those with low expression of ZFX. Multivariate analysis suggested that high expression of ZFX was an independent prognostic factor for CRC patients. In conclusion, our findings for the first time demonstrated that ZFX expression may be associated with the progress of CRC and suggested that ZFX has the potential value to be an effective prognostic predictor for CRC patients.
authors.affiliation: Department of General Surgery, The Sixth People's Hospital Affiliated to Shanghai Jiao Tong University 600 Yi-Shan Road, Shanghai 200233, China.
authors.forename: Xuebing
authors.initials: X
authors.lastname: Yan
authors.affiliation: Department of General Surgery, The Sixth People's Hospital Affiliated to Shanghai Jiao Tong University 600 Yi-Shan Road, Shanghai 200233, China.
authors.forename: Leilei
authors.initials: L
authors.lastname: Yan
authors.affiliation: Department of Neurosurgery, The Sixth People's Hospital Affiliated to Shanghai Jiao Tong University 600 Yi-Shan Road, Shanghai 200233, China.
authors.forename: Zuopeng
authors.initials: Z
authors.lastname: Su
authors.affiliation: Department of General Surgery, The Sixth People's Hospital Affiliated to Shanghai Jiao Tong University 600 Yi-Shan Road, Shanghai 200233, China.
authors.forename: Qingchao
authors.initials: Q
authors.lastname: Zhu
authors.affiliation: Department of General Surgery, The Sixth People's Hospital Affiliated to Shanghai Jiao Tong University 600 Yi-Shan Road, Shanghai 200233, China.
authors.forename: Sihong
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of General Surgery, The Sixth People's Hospital Affiliated to Shanghai Jiao Tong University 600 Yi-Shan Road, Shanghai 200233, China.
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Jin
authors.affiliation: Department of General Surgery, The Sixth People's Hospital Affiliated to Shanghai Jiao Tong University 600 Yi-Shan Road, Shanghai 200233, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D015153:Blotting, Western; D015179:Colorectal Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D051741:Kruppel-Like Transcription Factors / Q000032:analysis / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D060888:Real-Time Polymerase Chain Reaction
chemical_list: D014408:Biomarkers, Tumor; D051741:Kruppel-Like Transcription Factors; C062076:zinc finger protein, X-linked
keywords: ZFX; colorectal cancer; prognosis