title: DTI for the assessment of disease stage in patients with glomerulonephritis--correlation with renal histology.
abstract: OBJECTIVE
  To investigate whether DTI allows assessment of renal impairment and pathology in patients with chronic glomerulonephritis.
  
  
  METHODS
  Seventy-five patients and 20 healthy volunteers were enrolled in this study. Renal function and kidney biopsies were evaluated. For DTI, a respiratory-triggered coronal EPI sequence was performed (TR, 1400 ms; TE, 76 ms; diffusion direction, 6; NEX, 4; b values, 0 and 600 s/mm2; slices thickness, 6 mm, with no intersection gap). Renal ADC and FA values were calculated and compared between the groups. Correlations between ADC/FA and histopathology were evaluated.
  
  
  RESULTS
  ADC values decreased with increased stages. ADC differences in renal parenchyma at different disease stages were found, with the exception of the control group compared with stage 1 patients; similar results were obtained for FA. ADC values in the cortex and medulla in stage 1-3 patients were both statistically different, similar to the FA values. A significant negative correlation was found between the percentage of glomerulosclerosis and FA in the renal cortex (r =  -0.74), similar to the degree of tubulointerstitial fibrosis with FA in the medulla (r = -0.76).
  
  
  CONCLUSIONS
  ADC and FA values are correlated with the degree of renal impairment, the percentage of glomerulosclerosis, and area of interstitial fibrosis.
  
  
  CONCLUSIONS
  • DTI can be used to assess renal function impairment in patients with chronic glomerulonephritis. • ADC and FA values were correlated with tubulointerstitial fibrosis and glomerulosclerosis. • Identification of renal impairment is helpful for timely treatment. • DTI can be used for non-invasive assessment of renal pathology.
authors.affiliation: Tianjin Medical University, Tianjin, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Feng
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Ma
authors.forename: Jianlin
authors.initials: J
authors.lastname: Wu
authors.forename: Wei
authors.initials: W
authors.lastname: Fang
mesh_terms: D001706:Biopsy; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D005921:Glomerulonephritis / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007668:Kidney / Q000473:pathology*; D007672:Kidney Cortex / Q000473:pathology; D008297:Male; D051436:Renal Insufficiency, Chronic / Q000473:pathology* / Q000503:physiopathology; D012189:Retrospective Studies