title: Improving long-term outcomes after liver transplantation.
abstract: Long-term survival following liver transplantation is profoundly affected by conditions unrelated to graft function. Many causes of mortality are contributed to by the metabolic syndrome. The approach to metabolic syndrome in liver transplant recipients requires consideration of transplant-specific factors, particularly immunosuppression. Enhancing long-term outcomes for liver transplant recipients necessitates minimizing the amount of immunosuppression required to prevent rejection. Studies to determine the optimal approach to minimize the impact of metabolic syndrome and complications of immunosuppression in transplant recipients are needed.
authors.affiliation: Department of Medicine, Intermountain Medical Center, 5169 South Cottonwood Street, Murray, UT 84107, USA. Electronic address: michael.charlton@imail.org.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Charlton
mesh_terms: D002423:Cause of Death; D006084:Graft Rejection / Q000209:etiology; D006085:Graft Survival; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D016031:Liver Transplantation / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D024821:Metabolic Syndrome / Q000209:etiology; D009369:Neoplasms / Q000209:etiology; D012307:Risk Factors; D016019:Survival Analysis; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology
keywords: Graft rejection; Immunosuppression; Liver transplantation; Metabolic syndrome