title: GnRHa trigger for final oocyte maturation: is HCG trigger history?
abstract: Since the introduction of the gonadotrophin-releasing hormone analogues (GnRHa) protocol, it has become possible to trigger final oocyte maturation with a bolus of GnRHa. This leads to a significant reduction or complete elimination of ovarian hyperstimulation syndrome compared with human chorionic gonadotrophin (HCG) trigger. Early trials showed a severe luteal phase insufficiency after GnRHa trigger despite the application of standard luteal phase support protocols. Subsequent research has led to modifications of the luteal phase support, resulting in reproductive outcome comparable to that seen after HCG trigger in normal- and high-responders. GnRHa trigger facilitates a tailored approach to subsequent luteal phase support, taking into account the ovarian response to stimulation. In the future, GnRHa is likely to be used for trigger in all women co-treated with GnRH antagonists.
authors.affiliation: Faculty of Health, Aarhus University, Denmark; The Fertility Clinic, Skive Regional Hospital, Skive, Denmark. Electronic address: peter.humaidan@viborg.rm.dk.
authors.forename: Peter
authors.initials: P
authors.lastname: Humaidan
authors.affiliation: The Fertility Clinic, Skive Regional Hospital, Skive, Denmark.
authors.forename: Birgit
authors.initials: B
authors.lastname: Alsbjerg
mesh_terms: D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use*; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives*; D006801:Humans; D009866:Oogenesis / Q000187:drug effects*; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy
chemical_list: D005300:Fertility Agents, Female; D007987:Gonadotropin-Releasing Hormone
keywords: GnRHa; HCG; IVF; OHSS; luteal phase support; ovulation trigger