title: Paneth cell-like change in benign prostate can account for P504S (AMACR) reactivity.
abstract: Paneth cell-like neuroendocrine metaplasia of benign and cancerous prostate was described in 1992. Here, we note that P504S (AMACR), the cytoplasmic marker for prostate cancer used alone or in concert with basal cell markers, can be strongly reactive in benign prostatic acini with Paneth cell-like change.
authors.affiliation: Department of Pathology, Medical College of Wisconsin Milwaukee, WI, USA.
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Iczkowski
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008875:Middle Aged; D019879:Paneth Cells / Q000473:pathology*; D011467:Prostate / Q000473:pathology*; D019048:Prostatic Intraepithelial Neoplasia / Q000175:diagnosis; D011471:Prostatic Neoplasms / Q000175:diagnosis; D019998:Racemases and Epimerases
chemical_list: D014408:Biomarkers, Tumor; D019998:Racemases and Epimerases; C108352:alpha-methylacyl-CoA racemase
keywords: AMACR; P504S; Paneth; prostate