title: Iridoid glycosides isolated from Scrophularia dentata Royle ex Benth. and their anti-inflammatory activity.
abstract: Scrodentosides A-E (1-5), five new acylated iridoid glycosides, together with 19 known ones, were isolated from the whole plant of Scrophularia dentata Royle ex Benth. The structures of these isolated glycosides were elucidated by spectroscopic methods. Bioassay showed that compounds 7 and 11 had significant inhibitory effect against NF-κB activation with IC50 value of 43.7 μM and 1.02 μM respectively.
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.
authors.forename: Liuqiang
authors.initials: L
authors.lastname: Zhang
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.
authors.forename: Tiantian
authors.initials: T
authors.lastname: Zhu
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Qian
authors.affiliation: Murad Research Institute for Modernized Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Jinwen
authors.initials: J
authors.lastname: Xu
authors.affiliation: Tibetan Traditional Medical College, Lhasa 850000, China.
authors.forename: Gaawe
authors.initials: G
authors.lastname: Dorje
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.
authors.forename: Zhili
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China. Electronic address: guofj1972@hotmail.com.
authors.forename: Fujiang
authors.initials: F
authors.lastname: Guo
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China. Electronic address: ymlius@163.com.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Li
mesh_terms: D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology*; D057809:HEK293 Cells; D006801:Humans; D057889:Iridoid Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D016328:NF-kappa B / Q000037:antagonists & inhibitors*; D032266:Scrophularia / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D057889:Iridoid Glycosides; D016328:NF-kappa B
keywords: 8-O-acetylharpagide (PubChem CID: 160879); Ajugol(PubChem CID: 6452750); Ajugoside (PubChem CID: 179611); Anti-inflammation; Cis-harpagoside (PubChem CID: 13889700); Geniposidic acid(PubChem CID: 443354); Iridoid glycosides; NF-κB; Scrophularia dentata; Scropolioside D (PubChem CID: 6918700); Trans-harpagoside (PubChem CID: 5281542); harpagide (PubChem CID: 93045)