title: Anti-inflammatory potential of zootherapeutics derived from animals used in Brazilian traditional medicine.
abstract: BACKGROUND
  Animals are used for the treatment of diseases caused by inflammatory processes, although few studies evaluate their potential for these purposes.
  
  
  OBJECTIVE
  To evaluate the anti-inflammatory potential of zootherapeutic products derived from vertebrates used in Brazilian traditional medicine.
  
  
  METHODS
  The species analyzed were Tupinambis merianae, Iguana iguana, Crotalus durissus, Boa constrictor, and Euphractus sexcinctus. The methods used in anti-inflammatory assays were ear edema (topical) and paw (systemic).
  
  
  RESULTS
  With regard to topical anti-inflammatory activity, the fat from T. merianae, C. durissus, I. iguana, B. constrictor, and E. sexcinctus reduced inflammation, while for systemic anti-inflammatory activity, only the fat and the skin of C. durissus, the skin of I. iguana and the fat from B. constrictor reduced inflammation.
  
  
  CONCLUSIONS
  Studies should be conducted to evaluate the mechanisms of action for each product that demonstrated anti-inflammatory activity as well as against other inflammatory processes.
authors.affiliation: Departamento de Química Biológica, Universidade Regional do Cariri , Pimenta, Crato, CE , Brazil .
authors.forename: Felipe S
authors.initials: FS
authors.lastname: Ferreira
authors.forename: Samuel V
authors.initials: SV
authors.lastname: Brito
authors.forename: Débora L
authors.initials: DL
authors.lastname: Sales
authors.forename: Irwin R A
authors.initials: IR
authors.lastname: Menezes
authors.forename: Henrique D M
authors.initials: HD
authors.lastname: Coutinho
authors.forename: Emmanuel P
authors.initials: EP
authors.lastname: Souza
authors.forename: Waltécio O
authors.initials: WO
authors.lastname: Almeida
authors.forename: Rômulo R N
authors.initials: RR
authors.lastname: Alves
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification* / Q000627:therapeutic use*; D017821:Boidae; D001938:Brazil; D017839:Crotalus; D004487:Edema / Q000188:drug therapy / Q000473:pathology; D007076:Iguanas; D008297:Male; D008519:Medicine, Traditional / Q000379:methods*; D051379:Mice; D009821:Oils / Q000302:isolation & purification / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000737:chemistry*; D050151:Subcutaneous Fat / Q000737:chemistry*; D014020:Tissue Extracts / Q000302:isolation & purification / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D009821:Oils; D014020:Tissue Extracts
keywords: Anti-inflammatory activity; traditional medicine; zootherapy