title: Autologous bone marrow mononuclear cell transplant and surgical decompression in a dog with chronic spinal cord injury.
abstract: OBJECTIVE
  In dogs with deep analgesia caused by acute spinal cord injury from thoracolumbar disk herniation, autologous bone marrow mononuclear cell transplant may improve recovery. The purpose of the present study was to evaluate autologous bone marrow mononuclear cell transplant in a dog that had paraplegia and deep analgesia caused by chronic spinal cord injury.
  
  
  METHODS
  Autologous bone marrow mononuclear cell transplant was performed in a dog having paraplegia and analgesia for 3 years that was caused by a chronic spinal cord injury secondary to Hansen type I thoracolumbar disk herniation. Functional recovery was evaluated with electrophysiologic studies and the Texas Spinal Cord Injury Scale.
  
  
  RESULTS
  Somatosensory evoked potentials were absent before transplant but were detected after transplant. Functional improvement was noted (Texas Spinal Cord Injury Scale: before transplant, 0; after transplant, 6). No adverse events were observed.
  
  
  CONCLUSIONS
  Autologous bone marrow mononuclear cell transplant into the subarachnoid space may be a safe and beneficial treatment for chronic spinal cord injury in dogs.
authors.affiliation: From the Department of Bioartificial Organs, Institute for Frontier Medical Sciences, Kyoto University, Kyoto; and the Aikouishida Animal Hospital, Kanagawa, Japan.
authors.forename: Katsutoshi
authors.initials: K
authors.lastname: Tamura
authors.forename: Yasuji
authors.initials: Y
authors.lastname: Harada
authors.forename: Maki
authors.initials: M
authors.lastname: Kunimi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takemitsu
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Hara
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Nakamura
authors.forename: Masahiro
authors.initials: M
authors.lastname: Tagawa
mesh_terms: D000818:Animals; D001706:Biopsy / Q000662:veterinary; D016026:Bone Marrow Transplantation / Q000662:veterinary*; D002908:Chronic Disease; D019299:Decompression, Surgical / Q000662:veterinary*; D017586:Diskectomy / Q000662:veterinary; D004283:Dog Diseases / Q000175:diagnosis / Q000601:surgery*; D004285:Dogs; D005073:Evoked Potentials, Somatosensory; D007405:Intervertebral Disc Displacement / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery / Q000662:veterinary*; D008279:Magnetic Resonance Imaging / Q000662:veterinary; D009043:Motor Activity; D009460:Neurologic Examination / Q000662:veterinary; D020127:Recovery of Function; D013119:Spinal Cord Injuries / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery / Q000662:veterinary*; D014057:Tomography, X-Ray Computed / Q000662:veterinary; D014182:Transplantation, Autologous / Q000662:veterinary; D016896:Treatment Outcome