title: Cutaneous squamous cell carcinoma in two pediatric lung transplant patients on prolonged voriconazole treatment.
abstract: Oral voriconazole is commonly used for treatment and prophylaxis of invasive fungal disease post-LTx. Development of cutaneous SCC has been described in adult LTx recipients, although it is extremely rare in children. We describe two Caucasian children who developed cutaneous SCC beyond three yr post-LTx. Both developed severe photosensitivity, actinic keratosis and required curative surgical excision of the cutaneous SCC lesions. Neither patient developed metastatic lesions nor had allograft dysfunction as a result of the SCC or the change in medical treatments. The effect of voriconazole on the development of malignant skin lesions is discussed and a recommendation on dermatologic surveillance, preventive measures against phototoxicity and early treatment of SCC are provided.
authors.affiliation: Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Jackson Y
authors.initials: JY
authors.lastname: Wong
authors.forename: Paul
authors.initials: P
authors.lastname: Kuzel
authors.forename: John
authors.initials: J
authors.lastname: Mullen
authors.forename: Dale
authors.initials: D
authors.lastname: Lien
authors.forename: Muhammad
authors.initials: M
authors.lastname: Mahmood
authors.forename: Carol
authors.initials: C
authors.lastname: Conrad
authors.forename: Loretta
authors.initials: L
authors.lastname: Fiorillo
mesh_terms: D000293:Adolescent; D000935:Antifungal Agents / Q000009:adverse effects*; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced*; D002648:Child; D005260:Female; D006801:Humans; D008172:Lung Diseases, Fungal / Q000188:drug therapy* / Q000276:immunology; D016040:Lung Transplantation; D008297:Male; D010787:Photosensitivity Disorders / Q000139:chemically induced*; D029424:Pulmonary Disease, Chronic Obstructive / Q000601:surgery*; D012307:Risk Factors; D012878:Skin Neoplasms / Q000139:chemically induced*; D065819:Voriconazole / Q000009:adverse effects*
chemical_list: D000935:Antifungal Agents; D065819:Voriconazole
keywords: lung transplantation; malignancy; organ transplantation; pediatrics; skin cancer; squamous cell carcinoma; voriconazole