title: Effect of platelet-rich fibrin on frequency of alveolar osteitis following mandibular third molar surgery: a double-blinded randomized clinical trial.
abstract: OBJECTIVE
  To evaluate the effectiveness of platelet-rich fibrin (PRF) in preventing the development of alveolar osteitis (AO).
  
  
  METHODS
  In a double-blinded study, patients with bilateral impacted mandibular third molars underwent surgical extractions, with one socket receiving PRF and the other one serving as a control. The surgeon and patient were unaware of the study or control side. The predictor variable was the PRF application and was categorized as PRF and non-PRF. The outcome variable was the development of AO during the first postoperative week. Other study variables included age, gender, smoking status, irrigation volume, extraction difficulty, surgeon experience, and number of anesthetic cartridges. Data were analyzed using χ(2) and t tests, with the significance level set at a P value less than .05.
  
  
  RESULTS
  Seventy-eight patients (mean age, 25 yr) underwent 156 impacted third molar surgeries. The overall frequency of AO was 14.74% for all surgeries. The frequency of AO in the PRF group was significantly lower than in the non-PRF group (odds ratio = 0.44; P < .05).
  
  
  CONCLUSIONS
  Based on the results of the present study, PRF application may decrease the risk of AO development after mandibular third molar surgery.
authors.affiliation: Dental Research Center, Department of Oral and Maxillofacial, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Eshghpour
authors.affiliation: General Dentist, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Parisa
authors.initials: P
authors.lastname: Dastmalchi
authors.affiliation: Dentistry Student, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Amir Hossein
authors.initials: AH
authors.lastname: Nekooei
authors.affiliation: General Dentist, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: amir.h.nejat@outlook.com.
authors.forename: AmirHossein
authors.initials: A
authors.lastname: Nejat
mesh_terms: D000293:Adolescent; D000328:Adult; D001792:Blood Platelets; D004311:Double-Blind Method; D004368:Dry Socket / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D005337:Fibrin / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008964:Molar, Third / Q000601:surgery*; D014095:Tooth, Impacted / Q000601:surgery*; D055815:Young Adult
chemical_list: D005337:Fibrin