title: Synthesis of aza-fused isoquinolines through domino cross-aldol condensation and palladium-catalyzed intramolecular direct arylation.
abstract: A straightforward method has been developed for the synthesis of aroyl-substituted imidazo-/benzimidazo-fused isoquinolines. The cascade reaction proceeds via a cross-aldol condensation of 2-(1H-imidazol-1-yl/benzimidazolyl-1-yl)-1-arylethanones and 2-bromobenzaldehyde followed by palladium-catalyzed intramolecular C-H functionalization. This approach offers a simple and efficient alternative one-pot protocol for the assembly of imidazo/benzimidazo[2,1-a]isoquinolines in moderate to good yields.
authors.affiliation: Department of Chemistry, Birla Institute of Technology and Science , Pilani, 333031 Rajasthan, India.
authors.forename: Shiv
authors.initials: S
authors.lastname: Dhiman
authors.forename: Kasiviswanadharaju
authors.initials: K
authors.lastname: Pericherla
authors.forename: Nitesh K
authors.initials: NK
authors.lastname: Nandwana
authors.forename: Dalip
authors.initials: D
authors.lastname: Kumar
authors.forename: Anil
authors.initials: A
authors.lastname: Kumar