title: Nomogram for computing the value of similarity factor.
abstract: The objective of present work was to construct nomogram for obtaining a value of similarity factor (f2) by employing the values of number of observations (n) and sum of squared difference of percentage drug dissolved between reference (R) and test (T) products . The steps for rearrangement of equation of similarity factor are presented. The values of f2 were selected in the range of 45 to 100 for 4 to 12 observations (n) for computing the values of Linear regression analysis was performed between number of observations and . Perfect correlation was observed in each case. Nomogram was constructed and later it was validated by using drug dissolution data from literature and our laboratory. The use of nomogram is recommended during research and development work to investigate effect of formulation or process variables. The nomogram can also be used during change in manufacturing site or change in equipment. It is concluded that the steps for calculation of f2 can be truncated in the middle (i.e. at the step of calculation of factor and a decision of similarity/dissimilarity can be taken employing the nomogram.
authors.affiliation: Anand College of Pharmacy, Anand-388 001, India.
authors.forename: M C
authors.initials: MC
authors.lastname: Gohel
authors.affiliation: L. M. College of Pharmacy, Navarangpura, Ahmedabad-380 009, India.
authors.forename: A
authors.initials: A
authors.lastname: Ramkishan
authors.affiliation: L. M. College of Pharmacy, Navarangpura, Ahmedabad-380 009, India.
authors.forename: T M
authors.initials: TM
authors.lastname: Patel
authors.affiliation: L. M. College of Pharmacy, Navarangpura, Ahmedabad-380 009, India.
authors.forename: Radhika
authors.initials: R
authors.lastname: Pandya
authors.affiliation: L. M. College of Pharmacy, Navarangpura, Ahmedabad-380 009, India.
authors.forename: Vrunda
authors.initials: V
authors.lastname: Suthar
authors.affiliation: L. M. College of Pharmacy, Navarangpura, Ahmedabad-380 009, India.
authors.forename: Hiral
authors.initials: H
authors.lastname: Koradia
authors.affiliation: L. M. College of Pharmacy, Navarangpura, Ahmedabad-380 009, India.
authors.forename: D V
authors.initials: DV
authors.lastname: Madat
authors.affiliation: Institute of Pharmacy, Nirma University, S. G. Highway, Ahmedabad-382 481, India.
authors.forename: Shital
authors.initials: S
authors.lastname: Bariya
authors.affiliation: Institute of Pharmacy, Nirma University, S. G. Highway, Ahmedabad-382 481, India.
authors.forename: Tejal
authors.initials: T
authors.lastname: Mehta
keywords: Dissolution; nomogram; rearranged similarity function equation; similarity factor