title: The effects of catheter-based radiofrequency renal denervation on renal function and renal artery structure in patients with resistant hypertension.
abstract: There are no clinical studies on the effects of catheter-based radiofrequency renal denervation (RDN) on renal artery structure using 64-detector computed tomography (CT). A total of 39 patients with resistant hypertension received RDN and 38 patients received drug treatment. Mean systolic pressure and diastolic pressure in the RDN group decreased after 1, 3, 6, and 12 months of procedure (P<.05) and urinary protein level significantly decreased after 6 and 12 months (P<.05). The diameter, length, and sectional area of the renal artery; number of cases of atherosclerosis; and plaque burden of 64-detector CT renal arteriography did not change at 12 months of follow-up (P<.05), whereas the plaque burden increased significantly in the control group (P<.05). RDN significantly and persistently reduced blood pressure and decreased urinary protein excretion rate in patients with resistant hypertension and did not exhibit any adverse effect on renal function and renal artery structure.
authors.affiliation: Department of Cardiovascular, The Third Xiangya Hospital of Central South University, Changsha, China.
authors.forename: Zhi-Hui
authors.initials: ZH
authors.lastname: Zhang
authors.forename: Kan
authors.initials: K
authors.lastname: Yang
authors.forename: Feng-Lin
authors.initials: FL
authors.lastname: Jiang
authors.forename: Li-Xiong
authors.initials: LX
authors.lastname: Zeng
authors.forename: Wei-Hong
authors.initials: WH
authors.lastname: Jiang
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Wang
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D050197:Atherosclerosis / Q000453:epidemiology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D017115:Catheter Ablation / Q000009:adverse effects / Q000379:methods*; D004351:Drug Resistance; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000503:physiopathology / Q000628:therapy*; D015994:Incidence; D007668:Kidney / Q000294:innervation* / Q000503:physiopathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography / Q000379:methods; D058226:Plaque, Atherosclerotic / Q000453:epidemiology; D011507:Proteinuria / Q000517:prevention & control; D012077:Renal Artery / Q000000981:diagnostic imaging* / Q000473:pathology; D012189:Retrospective Studies; D013562:Sympathectomy / Q000009:adverse effects / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents