title: Multicenter clinical performance evaluation of BD Veritor™ system for rapid detection of respiratory syncytial virus.
abstract: BACKGROUND
  BD Veritor™ System for Rapid Detection of Respiratory Syncytial Virus (RSV) is a new-generation lateral flow immunochromatographic assay for objective detection of RSV in respiratory specimens from children.
  
  
  OBJECTIVE
  To evaluate the performance of BD Veritor™ System for Rapid Detection of RSV in respiratory specimens collected from pediatric patients.
  
  
  METHODS
  A prospective, multicenter clinical trial was undertaken at five study sites representing geographically diverse regions of the U.S. to assess the performance of the BD Veritor™ System for Rapid Detection of RSV in comparison to R-mix shell vial culture and ProFlu+ reverse transcription-PCR assay (Gen-Probe/Prodesse).
  
  
  RESULTS
  440 nasopharyngeal washes/aspirates (NPW/A) and 706 nasopharyngeal swab (NPS) specimens from U.S. subjects<20 years of age were collected and tested using the BD Veritor™ System and compared with shell vial culture and real-time RT-PCR results. Analysis of the data indicates the overall sensitivity and specificity for BD Veritor™ System for all sample types combined was 90% and 97.0% versus shell vial culture and 75.5% and 98.7% versus RT-PCR respectively.
  
  
  CONCLUSIONS
  Overall, the BD Veritor™ System for the Rapid Detection of RSV performed well when compared to both viral cell culture and RT-PCR in children.
authors.affiliation: Children's Mercy Hospitals and Clinics, Kansas City, MO 64108, United States; University of Missouri-Kansas City School of Medicine, Kansas City, MO 64108, United States.
authors.forename: J Jeremiah
authors.initials: JJ
authors.lastname: Bell
authors.affiliation: Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
authors.forename: Evan J
authors.initials: EJ
authors.lastname: Anderson
authors.affiliation: Penn State University College of Medicine, Hershey, PA, United States; Penn State Hershey Medical Center, Hershey, PA, United States.
authors.forename: Wallace H
authors.initials: WH
authors.lastname: Greene
authors.affiliation: University of Arkansas for Medical Sciences, Little Rock, AR, United States; Arkansas Children's Hospital, Little Rock, AR, United States.
authors.forename: José R
authors.initials: JR
authors.lastname: Romero
authors.affiliation: Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States.
authors.forename: Moheet
authors.initials: M
authors.lastname: Merchant
authors.affiliation: Children's Mercy Hospitals and Clinics, Kansas City, MO 64108, United States; University of Missouri-Kansas City School of Medicine, Kansas City, MO 64108, United States. Electronic address: rselvarangan@cmh.edu.
authors.forename: Rangaraj
authors.initials: R
authors.lastname: Selvarangan
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002846:Chromatography, Affinity / Q000379:methods*; D003955:Diagnostic Tests, Routine / Q000379:methods*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011446:Prospective Studies; D018357:Respiratory Syncytial Virus Infections / Q000175:diagnosis*; D018113:Respiratory Syncytial Virus, Human / Q000302:isolation & purification*; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D012680:Sensitivity and Specificity; D014481:United States; D014776:Virus Cultivation / Q000379:methods
keywords: Antigen; BD Veritor; Children; PCR; RSV