title: With NuRD, HDACs Go "Nerdy".
abstract: Reporting in a recent issue of Neuron, Yamada et al. (2014) show that the histone deacetylase (HDAC)-containing NuRD complex plays a critical role in shutting down expression of specific synaptogenesis-related genes in the cerebellum, resulting in enhanced differentiation of presynaptic structures. This work suggests that HDACs in neurons acquire specificity through NuRD.
authors.affiliation: Stem Cell Translational Research Center, Tongji Hospital, Tongji University School of Medicine, Shanghai 200092, China; Department of Psychiatry and Biobehavioral Sciences, IDDRC, University of California at Los Angeles, 635 Charles E. Young Drive, Los Angeles, CA 90095, USA; Kunming Biomed International and National Engineering Research Center of Biomedicine and Animal Science, Kunming 650500, China. Electronic address: yi.eve.sun@gmail.com.
authors.forename: Yi Eve
authors.initials: YE
authors.lastname: Sun
authors.affiliation: Stem Cell Translational Research Center, Tongji Hospital, Tongji University School of Medicine, Shanghai 200092, China.
authors.forename: Liming
authors.initials: L
authors.lastname: Cheng
authors.affiliation: Research Center for Pharmacology and Toxicology, The Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China. Electronic address: kphu@implad.ac.cn.
authors.forename: Keping
authors.initials: K
authors.lastname: Hu
mesh_terms: D000818:Animals; D001923:Brain Chemistry / Q000235:genetics*; D006801:Humans; D056245:Mi-2 Nucleosome Remodeling and Deacetylase Complex / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D013569:Synapses / Q000235:genetics*
chemical_list: D056245:Mi-2 Nucleosome Remodeling and Deacetylase Complex