title: Role of angiogenesis in bone repair.
abstract: Bone vasculature plays a vital role in bone development, remodeling and homeostasis. New blood vessel formation is crucial during both primary bone development as well as fracture repair in adults. Both bone repair and bone remodeling involve the activation and complex interaction between angiogenic and osteogenic pathways. Interestingly studies have demonstrated that angiogenesis precedes the onset of osteogenesis. Indeed reduced or inadequate blood flow has been linked to impaired fracture healing and old age related low bone mass disorders such as osteoporosis. Similarly the slow penetration of host blood vessels in large engineered bone tissue grafts has been cited as one of the major hurdle still impeding current bone construction engineering strategies. This article reviews the current knowledge elaborating the importance of vascularization during bone healing and remodeling, and the current therapeutic strategies being adapted to promote and improve angiogenesis.
authors.affiliation: Vascular Biology Lab, AU-KBC Research Centre, Anna University, MIT Campus, Chennai, India.
authors.forename: Uttara
authors.initials: U
authors.lastname: Saran
authors.affiliation: Department of Applied Clinical Science and Biotechnology, University of L' Aquila, L' Aquila, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Gemini Piperni
authors.affiliation: Vascular Biology Lab, AU-KBC Research Centre, Anna University, MIT Campus, Chennai, India; Department of Biotechnology, Anna University, Chennai, India. Electronic address: soovro@yahoo.ca.
authors.forename: Suvro
authors.initials: S
authors.lastname: Chatterjee
mesh_terms: D000818:Animals; D001846:Bone Development / Q000502:physiology*; D016723:Bone Remodeling / Q000502:physiology*; D002450:Cell Communication / Q000502:physiology; D042783:Endothelial Cells / Q000166:cytology / Q000502:physiology*; D006801:Humans; D018919:Neovascularization, Physiologic / Q000502:physiology*; D010006:Osteoblasts / Q000166:cytology / Q000502:physiology*; D010012:Osteogenesis / Q000502:physiology*; D023822:Tissue Engineering / Q000295:instrumentation / Q000379:methods*
keywords: Angiogenesis; Endothelial cells; Endothelial progenitor cells; Osteoblasts; Osteogenesis; VEGF