title: The CD200-tolerance signaling molecule associated with pregnancy success is present in patients with early-stage breast cancer but does not favor nodal metastasis.
abstract: OBJECTIVE
  The CD200-tolerance signaling molecule prevents pregnancy failure and is also expressed by a wide variety of malignant tumors. The effect of CD200 mRNA expression on progression of human tumors has been variable.
  
  
  METHODS
  A cross-sectional study was performed to examine the correlation between CD200 protein expression in the primary tumors from postoperative Stage I-IIIA human breast cancer and the likelihood of regional lymph node metastasis.
  
  
  RESULTS
  Fifty-eight percentage of patients had strong CD200(+) tumor staining (71% of Stage I and 53% Stage II-IIIA). Strong staining was associated with large T2-3 primary tumors compared to T1 tumors (64 versus 50%) and T2-3 N(+) versus T1 N(-) tumors (70 versus 63%), but this was not statistically significant. Nodal metastases were not more frequent in patients with strong CD200(+) staining (57% compared to 58% for weak/negative staining cases), and the metastatic tumor cells in regional lymph nodes were often CD200(-) when the primary tumor was CD200(+).
  
  
  CONCLUSIONS
  CD200 expression by early-stage human breast cancer cells in primary tumors did not correlate with increased regional lymph node metastasis.
authors.affiliation: Department of Medicine, McMaster University, Health Sciences Center Rm 3H1E, Hamilton, ON, Canada; Department of Molecular Medicine & Pathology, McMaster University, Hamilton, ON, Canada; Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Toronto General Research Institute, Toronto, ON, Canada.
authors.forename: David A
authors.initials: DA
authors.lastname: Clark
authors.forename: Sukhbinder
authors.initials: S
authors.lastname: Dhesy-Thind
authors.forename: Peter
authors.initials: P
authors.lastname: Ellis
authors.forename: Jennifer
authors.initials: J
authors.lastname: Ramsay
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000276:immunology*; D001943:Breast Neoplasms / Q000276:immunology* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000276:immunology*; D057809:HEK293 Cells; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000276:immunology*; D009367:Neoplasm Staging; D011247:Pregnancy
chemical_list: D015703:Antigens, CD; D009363:Neoplasm Proteins; C042739:antigens, CD200
keywords: CD200; human breast cancer; metastasis; mouse breast cancer models; pregnancy immunology; tumor immunology