title: In vitro methods in drug transporter interaction assessment.
abstract: Drug transporter proteins recruit to pharmacological barrier tissues and profoundly affect the ADME properties of a large number of drugs. In vitro assays optimized for drug transporters have grown into routine tools in the determination of molecular level interactions as well as prediction of barrier penetration and system level pharmacokinetics. Regulatory position mandates increasing interest in the application of these assays during drug development.
authors.forename: Márton
authors.initials: M
authors.lastname: Jani
authors.forename: Péter
authors.initials: P
authors.lastname: Krajcsi
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D001665:Binding Sites; D001681:Biological Assay / Q000379:methods*; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism; D055808:Drug Discovery / Q000379:methods*; D004347:Drug Interactions; D006801:Humans; D027361:Organic Anion Transporters / Q000037:antagonists & inhibitors / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000378:metabolism; D010599:Pharmacokinetics; D013379:Substrate Specificity
chemical_list: D018528:ATP-Binding Cassette Transporters; D027361:Organic Anion Transporters; D004364:Pharmaceutical Preparations