title: Interplay between Kaposi's sarcoma-associated herpesvirus and the innate immune system.
abstract: Understanding of the innate immune response to viral infections is rapidly progressing, especially with regards to the detection of DNA viruses. Kaposi's sarcoma-associated herpesvirus (KSHV) is a large dsDNA virus that is responsible for three human diseases: Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman's disease. The major target cells of KSHV (B cells and endothelial cells) express a wide range of pattern recognition receptors (PRRs) and play a central role in mobilizing inflammatory responses. On the other hand, KSHV encodes an array of immune evasion genes, including several pirated host genes, which interfere with multiple aspects of the immune response. This review summarizes current understanding of innate immune recognition of KSHV and the role of immune evasion genes that shape the antiviral and inflammatory responses.
authors.affiliation: Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Harlyne J. Norris Cancer Research Tower, 1450 Biggy Street, Los Angeles, CA 90033, USA.
authors.forename: Kevin
authors.initials: K
authors.lastname: Brulois
authors.affiliation: Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Harlyne J. Norris Cancer Research Tower, 1450 Biggy Street, Los Angeles, CA 90033, USA. Electronic address: jaeujung@med.usc.edu.
authors.forename: Jae U
authors.initials: JU
authors.lastname: Jung
mesh_terms: D019288:Herpesvirus 8, Human / Q000276:immunology*; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D050835:Interferon Regulatory Factors / Q000378:metabolism; D051192:Receptors, Pattern Recognition / Q000276:immunology; D012514:Sarcoma, Kaposi / Q000276:immunology* / Q000821:virology
chemical_list: D050835:Interferon Regulatory Factors; D051192:Receptors, Pattern Recognition
keywords: Innate immunity; KSHV