title: [Non-cirrhotic portal hypertension presented by acute upper gastrointestinal bleeding 7 years after oxaliplatin-chemotherapy].
abstract: After having received adjuvant FOLFOX treatment consisting of oxaliplatin, folinic acid and fluoruracil following hemicolectomy in colon cancer 7 years ago, the findings of non-cirrhotic portal hypertension presented by acute upper gastrointestinal bleeding in a 49-year old woman were interpreted as oxaliplatin-associated. Imaging techniques, hepatic venous pressure measurement and liver biopsy supported pre-sinusoidal damage due to NRH (nodular regenerative hyperplasia) as the underlying cause, even though histological findings were moderate. Following primary endoscopic treatment, a stable condition has thus far been achievable with standard drug therapy.
authors.affiliation: Abteilung für Innere Medizin I, Klinikum Wels, Österreich.
authors.forename: S
authors.initials: S
authors.lastname: Schwarz
authors.affiliation: Abteilung für Innere Medizin I, Klinikum Wels, Österreich.
authors.forename: M
authors.initials: M
authors.lastname: Suppan
authors.affiliation: Institut für Pathologie, Klinikum Wels, Österreich.
authors.forename: W
authors.initials: W
authors.lastname: Höbling
authors.affiliation: Institut für Radiologie, Klinikum Wels, Österreich.
authors.forename: A
authors.initials: A
authors.lastname: Grünberger
authors.affiliation: Abteilung für Innere Medizin I, Klinikum Wels, Österreich.
authors.forename: R
authors.initials: R
authors.lastname: Nömeyer
authors.affiliation: Abteilung für Innere Medizin I, Klinikum Wels, Österreich.
authors.forename: D
authors.initials: D
authors.lastname: Hubner
authors.affiliation: Abteilung für Innere Medizin I, Klinikum Wels, Österreich.
authors.forename: P
authors.initials: P
authors.lastname: Knoflach
mesh_terms: D000208:Acute Disease; D000970:Antineoplastic Agents / Q000009:adverse effects; D003937:Diagnosis, Differential; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced* / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D006975:Hypertension, Portal / Q000139:chemically induced* / Q000175:diagnosis* / Q000628:therapy; D008103:Liver Cirrhosis / Q000139:chemically induced / Q000175:diagnosis; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000009:adverse effects*; D000077150:Oxaliplatin; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin