title: A new combined therapy for functional organ preservation and survival in lateral oropharyngeal wall cancer.
abstract: CONCLUSIONS
  The outcome of this treatment was good, indicating that it is safe and effective. A favorable outcome was obtained, especially in patients with T3, N0-1, and N2a-b cancer, while outcome remained unfavorable in patients with T4a and N2c cancer. Consideration should be given to the need for intensity-modulated radiation therapy (IMRT) and maintenance therapy.
  
  
  OBJECTIVE
  To improve the survival and functional organ preservation rates in patients with lateral oropharyngeal squamous cell carcinoma.
  
  
  METHODS
  The primary site was treated conservatively by neoadjuvant chemotherapy and/or concurrent chemoradiation therapy. Chemotherapy was administered by superselective intra-arterial infusion and cervical lymph node metastasis was treated by radical neck dissection.
  
  
  RESULTS
  Among 71 patients, the 5- and 10-year overall survival rates were 85.1% and 63.5%, respectively; and the 5- and 10-year functional organ preservation rates were 61.0% and 51.6%, respectively. The outcomes were especially good in patients with T3 N0-1, and N2a-b cancer. All patients with N2c cancer had poor outcomes.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Nihon University School of Medicine , Tokyo.
authors.forename: Tohru
authors.initials: T
authors.lastname: Furusaka
authors.forename: Akira
authors.initials: A
authors.lastname: Matsuda
authors.forename: Akane
authors.initials: A
authors.lastname: Tanaka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsuda
authors.forename: Takeshi
authors.initials: T
authors.lastname: Asakawa
authors.forename: Shuntaro
authors.initials: S
authors.lastname: Shigihara
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D003131:Combined Modality Therapy; D003679:Deglutition / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D009960:Oropharynx / Q000503:physiopathology*; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends
keywords: Head and neck cancer; concurrent chemoradiation therapy; neck dissection; neoadjuvant chemotherapy; squamous cell carcinoma