title: An alternative approach for the treatment of vaginal atrophy.
abstract: OBJECTIVE
  The aim of this study was to determine the efficacy of a new topic non-hormonal treatment for postmenopausal women complaining of symptoms of vaginal atrophy.
  
  
  METHODS
  Patients included in the study were prescribed Sinecol gel (AM PHARMA Srl, Vimercate, Monza and Brianza, Italy) application once a day for 20 consecutive days. Sinecol gel is a topic compound for vaginal atrophy containing hyaluronic acid, that is known to improve vaginal elasticity, lactoperoxidase, Xantham gum and glucose oxidase, which have protective and antibacterial action. We evaluated each patient before and after treatment, both subjectively with the "Visual Analogical Scale" (VAS) and objectively with the "Vaginal Health Index" (VHI).
  
  
  RESULTS
  We observed a significant clinical improvement of the subjective and objective assessment of symptoms severity with a p value <0.001 at the end of the treatment compared to baseline.
  
  
  CONCLUSIONS
  Sinecol gel appears to be an effective and valid non-hormonal alternative to the estrogen therapy for vaginal atrophy.
authors.affiliation: Gynecology Department, San Raffaele Scientific Institute Vita-Salute San Raffaele University,School of Medicine, Milan, Italy - salvatore.stefano@hsr.it.
authors.forename: L
authors.initials: L
authors.lastname: Quaranta
authors.forename: J
authors.initials: J
authors.lastname: Ottolina
authors.forename: M
authors.initials: M
authors.lastname: Parma
authors.forename: R
authors.initials: R
authors.lastname: Chionna
authors.forename: F
authors.initials: F
authors.lastname: Sileo
authors.forename: M
authors.initials: M
authors.lastname: Dindelli
authors.forename: M
authors.initials: M
authors.lastname: Origoni
authors.forename: M
authors.initials: M
authors.lastname: Candiani
authors.forename: S
authors.initials: S
authors.lastname: Salvatore
mesh_terms: D000282:Administration, Intravaginal; D000368:Aged; D001284:Atrophy; D005260:Female; D005500:Follow-Up Studies; D005949:Glucose Oxidase / Q000008:administration & dosage*; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D007784:Lactoperoxidase / Q000008:administration & dosage*; D008875:Middle Aged; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage*; D017698:Postmenopause; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014622:Vaginal Creams, Foams, and Jellies; D014623:Vaginal Diseases / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology
chemical_list: D011135:Polysaccharides, Bacterial; D014622:Vaginal Creams, Foams, and Jellies; D006820:Hyaluronic Acid; D005949:Glucose Oxidase; D007784:Lactoperoxidase; C002563:xanthan gum