title: Chronic rhinocerebral mucormycosis: a rare case report and review of the literature.
abstract: Rhinocerebral mucormycosis is an invasive infection caused by filamentous fungi of the Mucoraceae family. The rhinocerebral form of the disease represents the most common form and has two distinct clinical entities. The common presentation consists of a rapidly progressive infection with high mortality rate, while the other presentation is that of a chronic infection with lower mortality. In the present paper we report a rare case of chronic rhinocerebral mucormycosis. An 85-year-old male with a 6-month history of purulent and odorous nasal discharge, and sporadic episodes of epistaxis and anosmia, presented to the outpatient department of our clinic. Initial cultures were positive only for Pseudomonas aeruginosa. The patient was unresponsive to ciprofloxacin treatment, developing necrotic areas of the nasal septum suspicious for rhinocerebral mucormycosis. Admission to the ENT clinic followed, with histopathologic evaluation of the vomer bone confirming the diagnosis. The patient was treated with amphotericin B and was discharged 3 weeks later on oral posaconazole therapy. Chronic rhinocerebral mucormycosis may present with atypical symptoms or coinfection with another agent. A high degree of clinical suspicion is required for correct diagnosis and prompt initiation of appropriate treatment.
authors.affiliation: ENT Department, University Hospital of Patras, Rion Patras, Greece.
authors.forename: Konstantina
authors.initials: K
authors.lastname: Dimaka
authors.forename: Antonios
authors.initials: A
authors.lastname: Mallis
authors.forename: Stefanos S
authors.initials: SS
authors.lastname: Naxakis
authors.forename: Markos
authors.initials: M
authors.lastname: Marangos
authors.forename: Theodoros A
authors.initials: TA
authors.lastname: Papadas
authors.forename: Theodoros
authors.initials: T
authors.lastname: Stathas
authors.forename: Nicholas S
authors.initials: NS
authors.lastname: Mastronikolis
mesh_terms: D000369:Aged, 80 and over; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001927:Brain Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D008297:Male; D009090:Mucorales / Q000187:drug effects / Q000302:isolation & purification / Q000502:physiology; D009091:Mucormycosis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D009668:Nose Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B
keywords: Chronic rhinocerebral mucormycosis; amphotericin B; invasive fungal infection