title: Measurement of the S-adenosyl methionine (SAMe) content in a range of commercial veterinary SAMe supplements.
abstract: OBJECTIVE
  To measure the percentage of the stated amount of S-adenosyl methionine present in a range of commercially available S-adenosyl methionine supplements for veterinary use.
  
  
  METHODS
  Sixty-four samples of products containing S-adenosyl methionine marketed to support liver function were obtained from five manufacturers via three commercial wholesalers. The amount of S-adenosyl methionine in each product was measured using high-pressure liquid chromatography.
  
  
  RESULTS
  There were greater than threefold variation in the percentage of measured S-adenosyl methionine compared to the stated amount on the packaging which was significantly (P < 0 · 001) related to the product group being measured.
  
  
  CONCLUSIONS
  Differences in received dose of S-adenosyl methionine between different products were marked and this could have a profound influence on studies that evaluate any variation in absorption of S-adenosyl methionine between different product formulations, the effectiveness of S-adenosyl methionine-based products in clinical cases or when translating the results of studies that have used a specific S-adenosyl methionine product to those produced by a different manufacturer.
authors.affiliation: Vet Freedom Ltd, PO Box 343, Brockenhurst, Hampshire, SO41 1BW.
authors.forename: C P
authors.initials: CP
authors.lastname: Sturgess
mesh_terms: D000818:Animals; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid / Q000662:veterinary; D019587:Dietary Supplements / Q000032:analysis*; D012436:S-Adenosylmethionine / Q000032:analysis*; D019155:Veterinary Drugs / Q000032:analysis / Q000592:standards
chemical_list: D019155:Veterinary Drugs; D012436:S-Adenosylmethionine