title: Diets rich in saturated and polyunsaturated fatty acids induce morphological alterations in the rat ventral prostate.
abstract: OBJECTIVE
  To evaluate the influence of dietary lipid quality on the body mass, carbohydrate metabolism and morphology of the rat ventral prostate.
  
  
  METHODS
  Wistar rats were divided into four groups: SC (standard chow), HF-S (high-fat diet rich in saturated fatty acids), HF-P (high-fat diet rich in polyunsaturated fatty acids) and HF-SP (high-fat diet rich in saturated and polyunsaturated fatty acids). We analyzed body mass, fat mass deposits, plasma blood, insulin resistance and the ventral prostate structure.
  
  
  RESULTS
  Groups that received high-fat diets were heavier and presented larger fat deposits than SC group. The HF-S and HF-SP groups had higher glucose, insulin and total cholesterol serum levels and insulin resistance compared with the SC. The acinar area, epithelium height and area density of the lumen were higher in the HF-SP than in the other groups. The epithelium area density and epithelial cell proliferation were greater in the HF-P and HF-SP than in the SC group. All of the groups that received high-fat diets had greater area density of the stroma, area density of smooth muscle cells and stromal cell proliferation compared with the SC group.
  
  
  CONCLUSIONS
  Diets rich in saturated and/or polyunsaturated fatty acids induced overweight. Independently of insulin resistance, polyunsaturated fatty acids increased prostate stromal and epithelial cell proliferation. Saturated fatty acids influenced only stromal cellular proliferation. These structural and morphometric alterations may be considered risk factors for the development of adverse remodeling process in the rat ventral prostate.
authors.affiliation: Department of Anatomy, State University of Rio de Janeiro, Urogenital Research Unit, Biomedical Center, Rio de Janeiro, Brazil.
authors.forename: Angélica
authors.initials: A
authors.lastname: Furriel
authors.affiliation: Department of Anatomy, State University of Rio de Janeiro, Urogenital Research Unit, Biomedical Center, Rio de Janeiro, Brazil.
authors.forename: Pamella
authors.initials: P
authors.lastname: Campos-Silva
authors.affiliation: Department of Anatomy, State University of Rio de Janeiro, Urogenital Research Unit, Biomedical Center, Rio de Janeiro, Brazil.
authors.forename: Paola Cariello Guedes Picarote
authors.initials: PC
authors.lastname: Silva
authors.affiliation: Department of Anatomy, State University of Rio de Janeiro, Urogenital Research Unit, Biomedical Center, Rio de Janeiro, Brazil.
authors.forename: Waldemar Silva
authors.initials: WS
authors.lastname: Costa
authors.affiliation: Department of Anatomy, State University of Rio de Janeiro, Urogenital Research Unit, Biomedical Center, Rio de Janeiro, Brazil.
authors.forename: Francisco José Barcellos
authors.initials: FJ
authors.lastname: Sampaio
authors.affiliation: Department of Anatomy, State University of Rio de Janeiro, Urogenital Research Unit, Biomedical Center, Rio de Janeiro, Brazil.
authors.forename: Bianca Martins
authors.initials: BM
authors.lastname: Gregório
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001837:Body Weights and Measures; D050260:Carbohydrate Metabolism / Q000187:drug effects; D059305:Diet, High-Fat; D004041:Dietary Fats / Q000494:pharmacology*; D005227:Fatty Acids / Q000494:pharmacology*; D007150:Immunohistochemistry; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D011467:Prostate / Q000033:anatomy & histology* / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids