title: Proteinticle/gold core/shell nanoparticles for targeted cancer therapy without nanotoxicity.
abstract: PGCS-NPs (40 nm) with excellent photo-thermal activity are developed, on the surface of which affibody peptides with specific affinity for EGFR and many small gold dots (1-3 nm) are densely presented. The IV-injected PGCS-NPs into EGFR-expressing tumor-bearing mice successfully perform targeted and photothermal therapy of cancer. It seems that the small gold dots released from disassembled PGCS-NPs are easily removed and never cause in vivo toxicity problems.
authors.affiliation: Department of Chemical and Biological Engineering, College of Engineering, Korea University, Anam-Ro 145, Seoul, 136-713, Republic of Korea.
authors.forename: Koo Chul
authors.initials: KC
authors.lastname: Kwon
authors.forename: Ju Hee
authors.initials: JH
authors.lastname: Ryu
authors.forename: Jong-Hwan
authors.initials: JH
authors.lastname: Lee
authors.forename: Eun Jung
authors.initials: EJ
authors.lastname: Lee
authors.forename: Ick Chan
authors.initials: IC
authors.lastname: Kwon
authors.forename: Kwangmeyung
authors.initials: K
authors.lastname: Kim
authors.forename: Jeewon
authors.initials: J
authors.lastname: Lee
mesh_terms: D000818:Animals; D061067:Antibodies, Monoclonal, Humanized / Q000276:immunology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D000068818:Cetuximab; D066246:ErbB Receptors / Q000276:immunology / Q000378:metabolism; D006046:Gold / Q000737:chemistry*; D006801:Humans; D007259:Infrared Rays; D008099:Liver / Q000473:pathology; D051379:Mice; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D010316:Particle Size; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D011993:Recombinant Fusion Proteins / Q000737:chemistry / Q000378:metabolism; D014183:Transplantation, Heterologous
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D010455:Peptides; D017319:Photosensitizing Agents; D011993:Recombinant Fusion Proteins; D006046:Gold; D066246:ErbB Receptors; D000068818:Cetuximab
keywords: core/shell; gold nanoparticle; nanotoxicity; photothermal therapy; proteinticle