title: Pyrroloquinoline quinone ameliorates l-thyroxine-induced hyperthyroidism and associated problems in rats.
abstract: Pyrroloquinoline quinone (PQQ) is believed to be a strong antioxidant. In this study, we have evaluated its hitherto unknown role in l-thyroxin (L-T4 )-induced hyperthyroidism considering laboratory rat as a model. Alterations in the serum concentration of thyroxin (T4 ) and triiodothyronine (T3 ); lipid peroxidation (LPO) of liver, kidney, heart, muscles and brain; in the endogenous antioxidants such as superoxide dismutase, catalase and glutathione and in serum total cholesterol, high-density lipoprotien, triglycerides, serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT) and urea were evaluated. Administration of l-T4 (500-µg kg(-1) body weight) enhanced not only the serum T3 and T4 levels but also the tissue LPO, serum SGOT, SGPT and urea with a parallel decrease in the levels of antioxidants and serum lipids. However, on simultaneous administration of PQQ (5 mg kg(-1) for 6 days), all these adverse effects were ameliorated, indicating the potential of PQQ in the amelioration of hyperthyroidism and associated problems. Possibly, the curative effects were mediated through inhibition of oxidative stress. We suggest that PQQ may be considered for therapeutic use for hyperthyroidism after dose standardization.
authors.affiliation: Thyroid Research Unit, School of Life Sciences, Devi Ahilya University, Indore, M. P., India.
authors.forename: Narendra
authors.initials: N
authors.lastname: Kumar
authors.forename: Anand
authors.initials: A
authors.lastname: Kar
authors.forename: Sunanda
authors.initials: S
authors.lastname: Panda
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000627:therapeutic use*; D005260:Female; D006980:Hyperthyroidism / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D009928:Organ Specificity; D018384:Oxidative Stress / Q000187:drug effects; D045542:PQQ Cofactor / Q000627:therapeutic use*; D017208:Rats, Wistar; D013974:Thyroxine / Q000097:blood / Q000633:toxicity*; D014284:Triiodothyronine / Q000378:metabolism
chemical_list: D000975:Antioxidants; D014284:Triiodothyronine; D045542:PQQ Cofactor; D013974:Thyroxine
keywords: PQQ; RIA; SGPT; TBA-reactive substances; antioxidant enzymes; hyperthyroidism; liver