title: Selective stabilization of abasic site-containing DNA by insertion of sterically demanding biaryl ligands.
abstract: Biaryl derivatives that consist of one DNA-intercalating unit and a sterically demanding component exhibit a specific behavior towards abasic site-containing DNA (AP-DNA) as determined by thermal DNA denaturation experiments, spectrometric titrations and CD spectroscopic analysis. Specifically, these ligands strongly stabilize AP-DNA towards dissociation, whereas they do not or only marginally affect the melting temperature of regular duplex DNA.
authors.affiliation: Department Chemie - Biologie, Universität Siegen, Adolf-Reichwein-Str. 2, 57068 Siegen (Germany).
authors.forename: Katja
authors.initials: K
authors.lastname: Benner
authors.forename: Anna
authors.initials: A
authors.lastname: Bergen
authors.forename: Heiko
authors.initials: H
authors.lastname: Ihmels
authors.forename: Phil Marvin
authors.initials: PM
authors.lastname: Pithan
mesh_terms: D004247:DNA / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry / Q000494:pharmacology; D007364:Intercalating Agents / Q000737:chemistry* / Q000494:pharmacology*; D008024:Ligands; D009691:Nucleic Acid Denaturation / Q000187:drug effects*; D013696:Temperature
chemical_list: D006571:Heterocyclic Compounds; D007364:Intercalating Agents; D008024:Ligands; D004247:DNA
keywords: DNA damage; DNA ligands; DNA recognition; abasic DNA; nitrogen heterocycles