title: Comparing moral judgments of patients with frontotemporal dementia and frontal stroke.
abstract: OBJECTIVE
  Several clinical reports have stated that patients with prefrontal lesions or patients with the behavioral variant of frontotemporal dementia share social cognition impairments. Moral reasoning is impaired in both conditions but there have been few investigations that directly compare this domain in the 2 groups.
  
  
  METHODS
  This work compared the moral judgments of these patient groups using a task designed to disentangle the contributions of intentions and outcomes in moral judgment. For both disorders, patients judged scenarios where the protagonists believed that they would cause harm but did not as being more permissible than the control group. Moreover, patients with frontotemporal dementia judged harmful outcomes in the absence of harmful intentions as less permissible than the control participants. There were no differences between the 2 conditions.
  
  
  CONCLUSIONS
  Both disorders involved impairments in integrating intention and outcome information for moral judgment. This study was the first, to our knowledge, to directly compare a social cognition domain in 2 frontal pathologies with different etiology. Our results highlighted the importance of comparing patients with vascular lesions and patients with neurodegenerative diseases.
authors.affiliation: Institute of Cognitive Neurology and Institute of Neuroscience, Favaloro University, Buenos Aires, Argentina2UDP-INECO Foundation Core on Neuroscience, Diego Portales University, Santiago, Chile3National Scientific and Technical Research Council, Buenos.
authors.forename: Sandra
authors.initials: S
authors.lastname: Baez
authors.affiliation: Institute of Cognitive Neurology and Institute of Neuroscience, Favaloro University, Buenos Aires, Argentina2UDP-INECO Foundation Core on Neuroscience, Diego Portales University, Santiago, Chile3National Scientific and Technical Research Council, Buenos.
authors.forename: Blas
authors.initials: B
authors.lastname: Couto
authors.affiliation: Institute of Cognitive Neurology and Institute of Neuroscience, Favaloro University, Buenos Aires, Argentina2UDP-INECO Foundation Core on Neuroscience, Diego Portales University, Santiago, Chile.
authors.forename: Teresa
authors.initials: T
authors.lastname: Torralva
authors.affiliation: Institute of Cognitive Neurology and Institute of Neuroscience, Favaloro University, Buenos Aires, Argentina5Department of Clinical Neurological Sciences, Western University, London, Canada.
authors.forename: Luciano A
authors.initials: LA
authors.lastname: Sposato
authors.affiliation: UDP-INECO Foundation Core on Neuroscience, Diego Portales University, Santiago, Chile6Laboratory of Cognitive and Social Neuroscience, Universidad Diego Portales, Santiago, Chile.
authors.forename: David
authors.initials: D
authors.lastname: Huepe
authors.affiliation: Universidad Javeriana, Facultad de Medicina, Instituto de Envejecimiento, Departamento de Psiquiatría y Salud Mental, Centro de Memoria y Cognición, Hospital San Ignacio, Bogota, Colombia8Universidad Nacional de Colombia, Bogota, Colombia.
authors.forename: Patricia
authors.initials: P
authors.lastname: Montañes
authors.affiliation: Universidad Javeriana, Facultad de Medicina, Instituto de Envejecimiento, Departamento de Psiquiatría y Salud Mental, Centro de Memoria y Cognición, Hospital San Ignacio, Bogota, Colombia.
authors.forename: Pablo
authors.initials: P
authors.lastname: Reyes
authors.affiliation: Universidad Javeriana, Facultad de Medicina, Instituto de Envejecimiento, Departamento de Psiquiatría y Salud Mental, Centro de Memoria y Cognición, Hospital San Ignacio, Bogota, Colombia.
authors.forename: Diana
authors.initials: D
authors.lastname: Matallana
authors.affiliation: National Scientific and Technical Research Council, Buenos Aires, Argentina9Instituto de Humanidades de la Facultad de Filosofía y Humanidades, Universidad Nacional de Córdoba, Córdoba, Argentina.
authors.forename: Nora S
authors.initials: NS
authors.lastname: Vigliecca
authors.affiliation: Unidad de Neurología Cognitiva y Demencias, Servicio de Neurología, Hospital del Salvador, Santiago, Chile11Facultad de Medicina y Centro de Investigación Avanzada en Educación, Universidad de Chile, Santiago, Chile12Departamento de Neurología, Clínica Al.
authors.forename: Andrea
authors.initials: A
authors.lastname: Slachevsky
authors.affiliation: Institute of Cognitive Neurology and Institute of Neuroscience, Favaloro University, Buenos Aires, Argentina2UDP-INECO Foundation Core on Neuroscience, Diego Portales University, Santiago, Chile3National Scientific and Technical Research Council, Buenos.
authors.forename: Facundo
authors.initials: F
authors.lastname: Manes
authors.affiliation: Institute of Cognitive Neurology and Institute of Neuroscience, Favaloro University, Buenos Aires, Argentina2UDP-INECO Foundation Core on Neuroscience, Diego Portales University, Santiago, Chile3National Scientific and Technical Research Council, Buenos.
authors.forename: Agustin
authors.initials: A
authors.lastname: Ibanez
mesh_terms: D000328:Adult; D002561:Cerebrovascular Disorders / Q000473:pathology / Q000503:physiopathology*; D057180:Frontotemporal Dementia / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D007600:Judgment / Q000502:physiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009014:Morals; D017397:Prefrontal Cortex / Q000473:pathology / Q000503:physiopathology*; D012938:Social Perception; D020521:Stroke