title: Anti-proliferative activity of 6-O-acyl-D-allose against the human leukemia MOLT-4F cell line.
abstract: The anti-proliferative activities of the 6-O-acyl derivatives of D-allose against the human leukemia MOLT-4F cell line were examined. The activity of the 6-O-dodecanoyl derivative (3) was approximately 30 times stronger than that of D-allose. An evaluation of the derivatives of 3 that occurred in a furanose form revealed the pyranose forms of 3 to be important for the anti-proliferative activity.
authors.affiliation: a Faculty of Agriculture, Department of Applied Biological Science , Kagawa University , Miki-cho , Kagawa , 761-0795 , Japan.
authors.forename: Ryo C
authors.initials: RC
authors.lastname: Yanagita
authors.forename: Katsuya
authors.initials: K
authors.lastname: Kobashi
authors.forename: Chisa
authors.initials: C
authors.lastname: Ogawa
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Ashida
authors.forename: Haruka
authors.initials: H
authors.lastname: Yamaashi
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kawanami
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005947:Glucose / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D007938:Leukemia / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents; C002055:allose; D005947:Glucose
keywords: anti-proliferative activity; cancer; d-allose; leukemia; rare sugar