title: Oxidative stress and vitiligo: the Nrf2-ARE signaling connection.
abstract: Hypersensitivity of epidermal melanocytes to oxidative stress is known to contribute to vitiligo pathogenesis. Molecular mechanisms that connect melanocyte redox homeostasis to the complex disease phenotype are not fully understood. Jian et al. show that vitiligo melanocytes have impaired nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element signaling and decreased activation of the antioxidant enzyme system. In patients with vitiligo, higher serum levels of IL-2 correlate with lower levels of hemeoxygenase-1, a product of the Nrf2 target gene.
authors.affiliation: Department of Dermatology, First Affiliated Hospital of Dalian Medical University, Dalian, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Qiu
authors.affiliation: Department of Dermatology, First Affiliated Hospital of Dalian Medical University, Dalian, China. Electronic address: szqdalian@163.com.
authors.forename: Zhiqi
authors.initials: Z
authors.lastname: Song
authors.affiliation: Department of Dermatology, University of Wisconsin, Madison, Wisconsin, USA. Electronic address: vsetaluri@dermatology.wisc.edu.
authors.forename: Vijayasaradhi
authors.initials: V
authors.lastname: Setaluri
mesh_terms: D061745:Antioxidant Response Elements / Q000502:physiology*; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D008297:Male; D008544:Melanocytes / Q000378:metabolism*; D051267:NF-E2-Related Factor 2 / Q000502:physiology*; D018384:Oxidative Stress; D015398:Signal Transduction / Q000502:physiology*; D014820:Vitiligo / Q000378:metabolism*
chemical_list: D051267:NF-E2-Related Factor 2; C495635:NFE2L2 protein, human; D006861:Hydrogen Peroxide