title: Trypanosoma brucei: meet the system.
abstract: African trypanosomes cause devastating diseases in humans and domestic animals. The parasites evolved early in the eukaryotic lineage and have numerous biochemical peculiarities that distinguish them from other systems. These include unconventional mechanisms for expressing nuclear and mitochondrial genes as well as unusual subcellular localizations for a variety of enzymes. Systems biology has arisen partly to allow contextualization of the massive datasets that describe individual chemical parts of biological systems. Here we describe recent efforts to collect and analyse data pertaining to all aspects of the trypanosome's biochemical physiology that go some way to describing the parasite as an integrated system.
authors.affiliation: Wellcome Trust Centre of Molecular Parasitology and Glasgow Polyomics, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, United Kingdom.
authors.forename: Fiona
authors.initials: F
authors.lastname: Achcar
authors.affiliation: Systems and Synthetic Biology, Department of Chemical and Biological Engineering, Chalmers University of Technology, Kemivägen 10, SE-412 96 Göteborg, Sweden.
authors.forename: Eduard J
authors.initials: EJ
authors.lastname: Kerkhoven
authors.affiliation: Wellcome Trust Centre of Molecular Parasitology and Glasgow Polyomics, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, United Kingdom. Electronic address: michael.barrett@glasgow.ac.uk.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Barrett
mesh_terms: D053263:Gene Regulatory Networks; D053858:Metabolic Networks and Pathways; D060066:Protein Interaction Maps; D049490:Systems Biology; D014346:Trypanosoma brucei brucei / Q000235:genetics / Q000502:physiology*