title: Elevated brachial-ankle pulse wave velocity is independently associated with microalbuminuria in a rural population.
abstract: Microalbuminuria is a marker of generalized endothelial dysfunction resulting from arterial stiffness or insulin resistance, and brachial-ankle pulse wave velocity (baPWV) is a good measure of arterial stiffness. We aimed to investigate whether elevated baPWV is independently associated with microalbuminuria. This study included 1,648 individuals aged over 40 who participated in the baseline Multi-Rural Cohort Study conducted in Korean rural communities between 2005 and 2006. Participants were classified into less than 30 mg/g as normoalbuminuria or 30-300 mg/g as microalbuminuriausing urinary albumin creatinine ratio (UACR). The median and Q1-Q3 baPWV values were significantly higher in the microalbuminuric group both in men (1,538, 1,370-1,777 cm/s vs. 1,776, 1,552-2,027 cm/s, P < 0.001) and women (1,461, 1,271-1,687 cm/s vs. 1,645, 1,473-1,915 cm/s, P < 0.001). BaPWV was independently associated with microalbuminuria in both genders after adjusting for pulse rate; fasting blood glucose; triglyceride; homeostatic model assessment insulin resistance (HOMAIR) and, history of hypertension and diabetes. Fasting blood sugar and HOMAIR were judged as having nothing to do with multicolinearity (r = 0.532, P < 0.001). Elevated baPWV was independently associated with microalbuminuria regardless of insulin resistance among rural subjects over 40 yr.
authors.affiliation: Department of Family Medicine, Hanyang University College of Medicine, Seoul, Korea.
authors.forename: Joo Youn
authors.identifier: 0000-0001-9338-643X
authors.initials: JY
authors.lastname: Seo
authors.affiliation: Department of Preventive Medicine/Institute of Community Health, Hanyang University College of Medicine, Seoul, Korea.
authors.forename: Mi Kyung
authors.identifier: 0000-0001-8503-2631
authors.initials: MK
authors.lastname: Kim
authors.affiliation: Department of Preventive Medicine/Institute of Community Health, Hanyang University College of Medicine, Seoul, Korea.
authors.forename: Bo Youl
authors.identifier: 0000-0003-0115-5736
authors.initials: BY
authors.lastname: Choi
authors.affiliation: Department of Preventive Medicine, Dong-A University College of Medicine, Busan, Korea.
authors.forename: Yu-Mi
authors.identifier: 0000-0003-1123-8690
authors.initials: YM
authors.lastname: Kim
authors.affiliation: Graduate School of Public Health, Seoul National University, Seoul, Korea.
authors.forename: Sung-Il
authors.identifier: 0000-0003-4085-1494
authors.initials: SI
authors.lastname: Cho
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
authors.forename: Jinho
authors.identifier: 0000-0003-2872-6105
authors.initials: J
authors.lastname: Shin
mesh_terms: D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism; D055109:Ankle Brachial Index; D000843:Ankle Joint / Q000503:physiopathology*; D001774:Blood Chemical Analysis; D001786:Blood Glucose / Q000032:analysis; D001916:Brachial Artery / Q000503:physiopathology*; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000175:diagnosis; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D063177:Pulse Wave Analysis; D012307:Risk Factors; D012424:Rural Population; D012709:Serum Albumin / Q000032:analysis; D014280:Triglycerides / Q000097:blood; D059289:Vascular Stiffness
chemical_list: D001786:Blood Glucose; D012709:Serum Albumin; D014280:Triglycerides
keywords: Albuminuria; Insulin Resistance; Risk Factors; Vascular Stiffness