title: Yeast synthetic biology for high-value metabolites.
abstract: Traditionally, high-value metabolites have been produced through direct extraction from natural biological sources which are inefficient, given the low abundance of these compounds. On the other hand, these high-value metabolites are usually difficult to be synthesized chemically, due to their complex structures. In the last few years, the discovery of genes involved in the synthetic pathways of these metabolites, combined with advances in synthetic biology tools, has allowed the construction of increasing numbers of yeast cell factories for production of these metabolites from renewable biomass. This review summarizes recent advances in synthetic biology in terms of the use of yeasts as microbial hosts for the identification of the pathways involved in the synthesis, as well as for the production of high-value metabolites.
authors.affiliation: Key Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China huangluqi@263.net zhang_xl@tib.cas.cn.
authors.forename: Zhubo
authors.initials: Z
authors.lastname: Dai
authors.affiliation: Key Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.affiliation: National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Guo
authors.affiliation: National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China huangluqi@263.net.
authors.forename: Luqi
authors.initials: L
authors.lastname: Huang
authors.affiliation: Key Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China zhang_xl@tib.cas.cn.
authors.forename: Xueli
authors.initials: X
authors.lastname: Zhang
mesh_terms: D053898:Biosynthetic Pathways; D060847:Metabolic Engineering; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D058615:Synthetic Biology
keywords: Saccharomyces cerevisiae; high-value metabolites; synthetic biology