title: Phenolic compounds from leaves of Casimiroa edulis showed adipogenesis activity.
abstract: Casimiroa edulis is known as cochitzapotl, and it belongs to a species of tropical fruiting tree in the family Rutaceae, native to eastern Mexico and Central America south to Costa Rica. In this study, we isolated two furocoumarins and two polymethoxyflavones from leaves of C. edulis and evaluated the functions of glucose and lipid metabolism activity with 3T3-L1 adipocytes. We discovered that the addition of furocoumarins increased glucose uptake and lipid accumulation in 3T3-L1 adipocyte. These results suggest that furocoumarin compounds can be used as functional food-derived compounds, to regulate adipocyte functioning for the management of metabolic syndrome, which is associated with dysfunctions of glucose and lipid metabolism.
authors.affiliation: a Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University , Uji, Kyoto , Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nagai
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Tanaka
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Goto
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Kusudo
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Takahashi
authors.forename: Teruo
authors.initials: T
authors.lastname: Kawada
mesh_terms: D041721:3T3-L1 Cells; D017667:Adipocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D050156:Adipogenesis / Q000187:drug effects*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D032081:Casimiroa / Q000737:chemistry*; D005227:Fatty Acids / Q000096:biosynthesis; D005947:Glucose / Q000378:metabolism; D005990:Glycerol / Q000378:metabolism; D050356:Lipid Metabolism / Q000187:drug effects; D051379:Mice; D010636:Phenols / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*
chemical_list: D005227:Fatty Acids; D010636:Phenols; D005947:Glucose; D005990:Glycerol
keywords: adipocyte; fatty acid (FA) syntheses; liquid chromatography/mass spectrometry (LC-MS); peroxisome proliferator-activated receptor (PPAR); phenolic compounds