title: Efficient feature selection and classification of protein sequence data in bioinformatics.
abstract: Bioinformatics has been an emerging area of research for the last three decades. The ultimate aims of bioinformatics were to store and manage the biological data, and develop and analyze computational tools to enhance their understanding. The size of data accumulated under various sequencing projects is increasing exponentially, which presents difficulties for the experimental methods. To reduce the gap between newly sequenced protein and proteins with known functions, many computational techniques involving classification and clustering algorithms were proposed in the past. The classification of protein sequences into existing superfamilies is helpful in predicting the structure and function of large amount of newly discovered proteins. The existing classification results are unsatisfactory due to a huge size of features obtained through various feature encoding methods. In this work, a statistical metric-based feature selection technique has been proposed in order to reduce the size of the extracted feature vector. The proposed method of protein classification shows significant improvement in terms of performance measure metrics: accuracy, sensitivity, specificity, recall, F-measure, and so forth.
authors.affiliation: Computer and Information Sciences Department, Universiti Teknologi PETRONAS, Bandar Seri Iskandar, 31750 Tronoh, Perak, Malaysia.
authors.forename: Muhammad Javed
authors.identifier: 0000-0002-8505-7705
authors.initials: MJ
authors.lastname: Iqbal
authors.affiliation: Fundamental and Applied Sciences Department, Universiti Teknologi PETRONAS, Bandar Seri Iskandar, 31750 Tronoh, Perak, Malaysia.
authors.forename: Ibrahima
authors.initials: I
authors.lastname: Faye
authors.affiliation: College of Sciences, Alfaisal University, P.O. Box 50927, Riyadh 11533, Saudi Arabia.
authors.forename: Brahim Belhaouari
authors.initials: BB
authors.lastname: Samir
authors.affiliation: Computer and Information Sciences Department, Universiti Teknologi PETRONAS, Bandar Seri Iskandar, 31750 Tronoh, Perak, Malaysia.
authors.forename: Abas Md
authors.initials: AM
authors.lastname: Said
mesh_terms: D019295:Computational Biology / Q000379:methods*; D011506:Proteins / Q000737:chemistry*
chemical_list: D011506:Proteins