title: Complex formation of fenchone with α-cyclodextrin: NMR titrations.
abstract: 13C NMR titration studies of inclusion complexes of bicyclic terpenoid, fenchone enantiomers with α-cyclodextrin revealed their 1:2 guest-host stoichiometry. Sequential binding constants were determined indicating a strong binding cooperativity of two α-cyclodextrin to fenchone. The overall association constants were used to calculate the Gibbs free energies of diastereomeric complex formation, which might be used as a measure of chiral recognition of fenchone by α-cyclodextrin. These results were compared with corresponding data derived for camphor, which is an isomeric bicyclic terpenoid.
authors.affiliation: Faculty of Chemistry, Warsaw University, Pasteura 1, 02-093 Warsaw, Poland.
authors.forename: Michał
authors.initials: M
authors.lastname: Nowakowski
authors.affiliation: Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5A, 02-106 Warsaw, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Ejchart
keywords: 13C NMR titration; Alpha-cyclodextrin; Chiral recognition; Diastereomeric complexes; Fenchone; Inclusion complexes; Sequential association constants