title: Predictive factors for survival and recurrence rate in patients with node-negative gastric cancer--a European single-centre experience.
abstract: OBJECTIVE
  Gastric cancer is a common disease with poor prognosis. Lymph node involvement is the strongest prognostic factor regarding survival in curatively (R0) resected patients. The aim of this study was to determine if a subgroup with higher risk for tumour recurrence exists in patients with node-negative gastric cancer. Furthermore, we aimed to identify prognostic factors and recurrence patterns for this subgroup.
  
  
  METHODS
  We collected demographical, clinical, pathohistological and follow-up data from 1,074 patients with gastric cancer in a prospectively maintained database. In 228 cases, R0 resections for node-negative gastric cancer were performed. The median follow-up period was 59 months. Statistical analysis was performed using SPSS 19.0.
  
  
  RESULTS
  The 5- , 10- and 15-year overall survival was 83, 75.5 and 73 %, respectively, with a disease-free survival of 78, 73 and 73 %. Tumour recurrence was observed in 18.9 % (43 cases), 14 % of which were diagnosed after more than 5 years. Gender, T-category , lymphangioinvasion, tumour differentiation, serosal infiltration, histological growth pattern, tumour size and classification according to Lauren were significant prognostic factors for overall survival in univariate analysis. Multivariate analysis showed tumour size and female sex to be independent prognostic factors. Non-exophytic tumour growth was a relevant factor for the development of local recurrence. Diffuse type gastric cancers as well as signet ring cells were significantly associated with the development of peritoneal carcinomatosis, and male gender with hematogenous metastases.
  
  
  CONCLUSIONS
  Multimodal treatment and individual follow-up might be beneficial in patients with higher risk of recurrence after R0 resection of node-negative gastric cancer.
authors.affiliation: Department of General, Visceral and Vascular Surgery, University Hospital of Jena, Erlanger Allee 101, 07747, Jena, Germany, yves.dittmar@med.uni-jena.de.
authors.forename: Yves
authors.initials: Y
authors.lastname: Dittmar
authors.forename: Silke
authors.initials: S
authors.lastname: Schüle
authors.forename: Alexander
authors.initials: A
authors.lastname: Koch
authors.forename: Falk
authors.initials: F
authors.lastname: Rauchfuss
authors.forename: Hubert
authors.initials: H
authors.lastname: Scheuerlein
authors.forename: Utz
authors.initials: U
authors.lastname: Settmacher
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005743:Gastrectomy; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology* / Q000473:pathology; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000401:mortality* / Q000473:pathology* / Q000601:surgery