title: Cytoplasmic HSP90α expression is associated with perineural invasion in pancreatic cancer.
abstract: Pancreatic cancer (PC) is an aggressive and devastating disease with a dismal prognosis. The study aimed to investigate the role of HSP90α and PDIA3 in patients with PC. Immunohistochemistry was performed on tissue microarrays containing 186 pairs of PC and normal pancreatic tissues to assess the expression levels of HSP90α and PDIA3. The expression levels of cytoplasmic HSP90α (P = 0.032) and PDIA3 (P = 0.043) in PCs were significantly higher than those in normal pancreas tissues, but nuclear HSP90α showed lower expression in PC tissues (P = 0.002). In addition, cytoplasmic expression of HSP90α and PDIA3 was significantly associated with perineural invasion (PNI) (P = 0.004) and sex (P = 0.014), respectively. These results indicate that cytoplasmic HSP90α may serve as a biomarker for PNI in PCs.
authors.affiliation: Department of Gastroenterology, Shanghai East Hospital, Tongji University School of Medicine Shanghai, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Department of Gastroenterology, Shanghai East Hospital, Tongji University School of Medicine Shanghai, China ; Department of Gastroenterology, Tongji Institute of Digestive Diseases, Tongji Hospital, Tongji University School of Medicine Shanghai, China.
authors.forename: Bensong
authors.initials: B
authors.lastname: Duan
authors.affiliation: Department of Gastroenterology, Tongji Institute of Digestive Diseases, Tongji Hospital, Tongji University School of Medicine Shanghai, China.
authors.forename: Chengzhi
authors.initials: C
authors.lastname: He
authors.affiliation: Department of Gastroenterology, Shanghai East Hospital, Tongji University School of Medicine Shanghai, China.
authors.forename: Shasha
authors.initials: S
authors.lastname: Geng
authors.affiliation: Shanghai Engineering Center for Molecular Medicine, National Engineering Center for Biochip at Shanghai Shanghai, China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Shen
authors.affiliation: Shanghai Engineering Center for Molecular Medicine, National Engineering Center for Biochip at Shanghai Shanghai, China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Shanghai Engineering Center for Molecular Medicine, National Engineering Center for Biochip at Shanghai Shanghai, China ; Institute of CMC Biobank and Translational Medicine Taizhou, Jiangsu, China.
authors.forename: Haihui
authors.initials: H
authors.lastname: Sheng
authors.affiliation: Department of Gastroenterology, Tongji Institute of Digestive Diseases, Tongji Hospital, Tongji University School of Medicine Shanghai, China.
authors.forename: Changqing
authors.initials: C
authors.lastname: Yang
authors.affiliation: Department of Gastroenterology, Shanghai East Hospital, Tongji University School of Medicine Shanghai, China ; Department of Gastroenterology, Tongji Institute of Digestive Diseases, Tongji Hospital, Tongji University School of Medicine Shanghai, China ; Shanghai Engineering Center for Molecular Medicine, National Engineering Center for Biochip at Shanghai Shanghai, China.
authors.forename: Hengjun
authors.initials: H
authors.lastname: Gao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D003593:Cytoplasm / Q000378:metabolism; D005260:Female; D018841:HSP90 Heat-Shock Proteins / Q000032:analysis / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000473:pathology*; D010525:Peripheral Nerves / Q000473:pathology; D019704:Protein Disulfide-Isomerases / Q000032:analysis / Q000096:biosynthesis*; D046888:Tissue Array Analysis
chemical_list: D014408:Biomarkers, Tumor; D018841:HSP90 Heat-Shock Proteins; C533585:HSP90AA2P protein, human; D019704:Protein Disulfide-Isomerases; C085868:PDIA3 protein, human
keywords: HSP90α; PDIA3; Pancreatic cancer; perineural invasion