title: Involvement of platelet-derived microparticles in tumor progression and thrombosis.
abstract: Platelet-derived microparticles (PMPs) represent the most abundant microparticle (MP) subtype. Their presence reflects platelet activity, physiopathology, and the thrombotic state of cancer patients. The quantity and composition of PMPs strictly depends on the way MPs were generated. Because platelets play a key role in cancer progression, as well as formation of metastasis, PMPs also may be important in the proliferation of cancer cells, cancer cell interactions, metastatic progression, angiogenesis, and inflammation. Alternatively, the concentration of circulating PMPs may differ according to the stage of a cancer and thus potentially could be used as a biomarker. Here we review the mechanisms underlying the generation and composition of PMPs and the clinical and experimental studies describing the involvement of PMPs in cancer and the Trousseau syndrome. Lastly, we focus on their clinical relevance, as well as their potential application as biomarkers in cancer.
authors.affiliation: Aix Marseille Université, INSERM UMR-S1076, Marseille, France.
authors.forename: Soraya
authors.initials: S
authors.lastname: Mezouar
authors.affiliation: Aix Marseille Université, INSERM UMR-S1076, Marseille, France.
authors.forename: Diane
authors.initials: D
authors.lastname: Mege
authors.affiliation: Aix Marseille Université, INSERM UMR-S1076, Marseille, France.
authors.forename: Roxane
authors.initials: R
authors.lastname: Darbousset
authors.affiliation: Service de médecine interne et pathologie vasculaire, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris, Paris, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Farge
authors.affiliation: Service d'oncologie, Institut Sainte-Catherine, Avignon, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Debourdeau
authors.affiliation: Aix Marseille Université, INSERM UMR-S1076, Marseille, France; Laboratoire d'Hématologie, Centre Hospitalo-Universitaire Conception, Marseille, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Dignat-George
authors.affiliation: Aix Marseille Université, INSERM UMR-S1076, Marseille, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Panicot-Dubois
authors.affiliation: Aix Marseille Université, INSERM UMR-S1076, Marseille, France. Electronic address: christophe.dubois@univ-amu.fr.
authors.forename: Christophe
authors.initials: C
authors.lastname: Dubois
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D001792:Blood Platelets / Q000473:pathology*; D055252:Cell-Derived Microparticles / Q000473:pathology*; D018450:Disease Progression; D006801:Humans; D009369:Neoplasms / Q000150:complications*; D013927:Thrombosis / Q000175:diagnosis* / Q000209:etiology
chemical_list: D014408:Biomarkers, Tumor