title: Development of miniature mass spectrometry systems for bioanalysis outside the conventional laboratories.
abstract: Mass spectrometry (MS) is known for highly specific and sensitive analysis. The general applicability of this technique makes it a good candidate for biological applications over a much broader range than is now the case. The limiting factors preventing MS from being applied at the biologist's bench or in a physician's office are identified as the large size of the systems, as well as the complicated analytical procedures required. An approach for developing miniature MS analysis systems with simplified operational procedures is described and the associated technical developments are discussed.
authors.affiliation: Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Zhou
authors.forename: Jiangjiang
authors.initials: J
authors.lastname: Liu
authors.forename: Robert Graham
authors.initials: RG
authors.lastname: Cooks
authors.forename: Zheng
authors.initials: Z
authors.lastname: Ouyang
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D006801:Humans; D007753:Laboratories; D013058:Mass Spectrometry / Q000379:methods*; D053719:Tandem Mass Spectrometry / Q000379:methods*