title: Neutrophil to Lymphocyte Ratio is Related to Stent Thrombosis and High Mortality in Patients With Acute Myocardial Infarction.
abstract: We investigated whether the neutrophil to lymphocyte ratio (NLR) can predict stent thrombosis (STh) and high mortality rate in patients with ST-segment elevation myocardial infarction (STEMI). We analyzed data of 102 patients with STh and 450 patients with STEMI admitted to 2 high volume hospitals. Preprocedural NLR was significantly higher in patients with STh (P < .001). There was a significantly higher mortality rate in patients with high NLR during hospitalization (P < .001). Also, in the STh group there was a significantly higher mortality rate in patients with high NLR (P < .001). In receiver-operating characteristic analysis, NLR >4.8 had 56% sensitivity and 68% specificity for predicting STh. The NLR >4.9 had 70% sensitivity and 65% specificity for predicting in-hospital mortality. On multivariate regression analysis, NLR was found to be significantly related to STh. In patients with STEMI, preprocedural high NLR is associated with both STh and higher mortality rates.
authors.affiliation: Department of Cardiology, Bağcilar Education and Research Hospital, Istanbul, Turkey drburakayca@yahoo.com.tr.
authors.forename: Burak
authors.initials: B
authors.lastname: Ayça
authors.affiliation: Department of Cardiology, Muğla Sıtkı Kocman University School of Medicine, Muğla, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Akın
authors.affiliation: Department of Cardiology, Mehmet Akif Ersoy Chest and Cardiovascular Surgery Education and Research Hospital, Istanbul, Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Celik
authors.affiliation: Department of Cardiology, Bağcilar Education and Research Hospital, Istanbul, Turkey.
authors.forename: Irfan
authors.initials: I
authors.lastname: Sahin
authors.affiliation: Department of Cardiology, Bağcilar Education and Research Hospital, Istanbul, Turkey.
authors.forename: S Sezai
authors.initials: SS
authors.lastname: Yildiz
authors.affiliation: Department of Cardiology, Bağcilar Education and Research Hospital, Istanbul, Turkey.
authors.forename: I Ilker
authors.initials: II
authors.lastname: Avci
authors.affiliation: Department of Cardiology, Near East Universty, Mersin, Turkey.
authors.forename: Kamil
authors.initials: K
authors.lastname: Gulsen
authors.affiliation: Department of Cardiology, Bağcilar Education and Research Hospital, Istanbul, Turkey.
authors.forename: Ertugrul
authors.initials: E
authors.lastname: Okuyan
authors.affiliation: Department of Cardiology, Bağcilar Education and Research Hospital, Istanbul, Turkey.
authors.forename: M Hakan
authors.initials: MH
authors.lastname: Dinckal
mesh_terms: D000328:Adult; D000368:Aged; D019540:Area Under Curve; D016009:Chi-Square Distribution; D003328:Coronary Thrombosis / Q000097:blood / Q000209:etiology* / Q000276:immunology / Q000401:mortality; D005260:Female; D061847:Hospitals, High-Volume; D006801:Humans; D016015:Logistic Models; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis / Q000276:immunology / Q000401:mortality / Q000628:therapy*; D009504:Neutrophils / Q000276:immunology*; D016017:Odds Ratio; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000295:instrumentation* / Q000401:mortality; D011237:Predictive Value of Tests; D012372:ROC Curve; D012189:Retrospective Studies; D012307:Risk Factors; D015607:Stents; D013997:Time Factors; D016896:Treatment Outcome; D014421:Turkey / Q000453:epidemiology
keywords: ST segment elevation myocardial infarction; mortality; neutrophil to lymphocyte ratio; stent thrombosis