title: Selenium adjuvant therapy in septic patients selected according to Carrico index.
abstract: OBJECTIVE
  The objective of this paper is to highlight the selected group of patients in which adjuvant therapy seems to have a more pronounced positive effect.
  
  
  METHODS
  65 septic patients from the prospective observational study Se-AOX (2008-2012) (ClinicalTrials.gov Identifier: NCT02026856) were divided into a Se group, receiving sodium selenite in a continual infusion of 750μg/24h for 6 days, and a placebo group. They were subsequently divided into subgroups according to the initial Carrico index (CI) on the day of admission: CI>200 and CI<200. Dynamical changes in glutathione peroxidase (GPx), glutathione reductase (GR) and superoxide dismutase activities were recorded at two day intervals. Clinical parameters and mortality were compared.
  
  
  RESULTS
  The CI increased in subgroup Se-CI<200 with negative correlation against subgroup Placebo-CI<200 during the last measuring period (p<0.02). GPx activity increased in selenium subgroups with negative correlation against placebo subgroups (p<0.01). SOD activity was elevated in all subgroups in comparison with values of healthy subjects.
  
  
  CONCLUSIONS
  Adjuvant selenium therapy seems to be beneficial for a selected group of patients with acute lung injury. However, as is clear from the results discussed, this is not the case with persistent renal failure, as this leads to an inability to maintain synthetic renal function and ensure GPx synthesis.
authors.affiliation: 1st Clinic of Anaesthesiology and Intensive Care Medicine, Louis Pasteur University Hospital in Košice, Slovak Republic.
authors.forename: Ladislav
authors.initials: L
authors.lastname: Kočan
authors.affiliation: Department of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, Slovak Republic. Electronic address: janka.vaskova@upjs.sk.
authors.forename: Janka
authors.initials: J
authors.lastname: Vašková
authors.affiliation: Department of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, Slovak Republic.
authors.forename: Ladislav
authors.initials: L
authors.lastname: Vaško
authors.affiliation: 1st Clinic of Anaesthesiology and Intensive Care Medicine, Louis Pasteur University Hospital in Košice, Slovak Republic.
authors.forename: Jana
authors.initials: J
authors.lastname: Simonová
authors.affiliation: 2nd Clinic of Surgery, Louis Pasteur University Hospital in Košice, Slovak Republic.
authors.forename: Róbert
authors.initials: R
authors.lastname: Simon
authors.affiliation: 1st Clinic of Anaesthesiology and Intensive Care Medicine, Louis Pasteur University Hospital in Košice, Slovak Republic.
authors.forename: Jozef
authors.initials: J
authors.lastname: Firment
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000008:administration & dosage*; D017024:Chemotherapy, Adjuvant; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects; D011446:Prospective Studies; D012643:Selenium / Q000008:administration & dosage*; D018805:Sepsis / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000975:Antioxidants; D005979:Glutathione Peroxidase; D012643:Selenium
keywords: Oxidative stress; Oxygenation index; Renal functions; Selenium; Sepsis