title: Impaired hypoxia-inducible factor (HIF) regulation by hyperglycemia.
abstract: The mechanisms that contribute to the development of diabetes complications remain unclear. A defective reaction of tissues to hypoxia has recently emerged as a new pathogenic mechanism and consists of a complex repression of hypoxia-inducible factor (HIF), which is the main regulator of the adaptive response to hypoxia. This paper discusses the mechanisms by which hyperglycaemia contributes to HIF repression in diabetes. Furthermore, a comprehensive analysis of the functional relevance of these new findings to the development of chronic diabetes complications is provided, along with examples from animal models and clinics.
authors.affiliation: Department of Molecular Medicine and Surgery, Karolinska Institutet, Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska University Hospital, L1:01, 17176, Stockholm, Sweden, sergiu-bogdan.catrina@ki.se.
authors.forename: Sergiu-Bogdan
authors.initials: SB
authors.lastname: Catrina
mesh_terms: D000818:Animals; D003920:Diabetes Mellitus / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000378:metabolism*; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D012160:Retina / Q000378:metabolism; D014947:Wounds and Injuries / Q000378:metabolism
chemical_list: D051793:Hypoxia-Inducible Factor 1