title: Low level of basal testosterone: a significant risk factor for poor oocyte yield after ovulation induction.
abstract: The objective of this study was to further investigate the association of low androgen levels and poor ovarian response or negative pregnancy outcome in in vitro fertilisation treatment using a retrospective cohort study. Chinese women (n=1950) of relatively young age, with normal range of basal FSH and antral follicle count undergoing an in vitro fertilisation cycle were selected and testosterone and dehydroepiandrosterone sulfate levels were measured on Day 3 of the menstrual cycle before subsequent in vitro fertilisation treatment. The main outcome measures of the study were ovarian stimulation parameters and clinical pregnancy. Basal testosterone levels of poor responders and non-pregnant women were significantly lower than normal responders and pregnant women, respectively. Patients with low basal testosterone levels had significantly lower number of mature oocytes, cleavage-stage embryos, frozen embryos, lower fertilisation and pregnancy rates and required higher doses of gonadotrophins. Androgen levels had no correlation with early spontaneous abortion rates. Multivariable logistic analysis revealed that low basal testosterone (<0.88nmolL(-1)) was an independent risk factor for poor oocyte yield (odds ratio: 1.61; 95% confidence interval: 1.01-2.57; P=0.045). In conclusion, a low level of basal testosterone was a significant risk factor for poor oocyte yield after ovarian stimulation and might negatively influence pregnancy chances with in vitro fertilisation. Basal dehydroepiandrosterone sulfate levels were not predictive for poor ovarian response or negative pregnancy outcome in this population.
authors.affiliation: Department of Obstetrics and Gynaecology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, 107 Yanjiang Road, Guangzhou 510120, Guangdong, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Guo
authors.affiliation: Department of Obstetrics and Gynaecology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, 107 Yanjiang Road, Guangzhou 510120, Guangdong, China.
authors.forename: Qingxue
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Obstetrics and Gynaecology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, 107 Yanjiang Road, Guangzhou 510120, Guangdong, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Obstetrics and Gynaecology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, 107 Yanjiang Road, Guangzhou 510120, Guangdong, China.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Obstetrics and Gynaecology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, 107 Yanjiang Road, Guangzhou 510120, Guangdong, China.
authors.forename: Dongzi
authors.initials: D
authors.lastname: Yang
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002681:China; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D004624:Embryo Transfer; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage* / Q000009:adverse effects; D005307:Fertilization in Vitro / Q000009:adverse effects; D006801:Humans; D016018:Least-Squares Analysis; D016015:Logistic Models; D015999:Multivariate Analysis; D016017:Odds Ratio; D054315:Oocyte Retrieval / Q000009:adverse effects; D010060:Ovulation / Q000187:drug effects*; D010062:Ovulation Induction / Q000009:adverse effects; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D012307:Risk Factors; D013739:Testosterone / Q000097:blood*; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D005300:Fertility Agents, Female; D013739:Testosterone; D019314:Dehydroepiandrosterone Sulfate