title: Recombinant tissue-type plasminogen activator (rt-PA) therapy in an acute stroke patient taking dabigatran etexilate: a case report and literature review.
abstract: Whether recombinant tissue-type plasminogen activator (rt-PA) therapy can be administered in acute stroke patients treated with dabigatran remains controversial. We administered rt-PA (0.6 mg/kg) in an acute stroke patient treated with dabigatran (110 mg bid) whose activated partial thromboplastin time (APTT) was 37.1 seconds 113 minutes after onset, 10 hours after the last dose of dabigatran. His symptoms improved from the National Institute of Health Stroke Scale score of 10 to 1 after treatment without hemorrhagic complications. The administration of rt-PA therapy is feasible in acute stroke patients on dabigatran when taking into account the APTT and time from the last dose.
authors.affiliation: Department of Cerebrovascular Medicine and Neurology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Japan.
authors.forename: Emi
authors.initials: E
authors.lastname: Tabata
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yasaka
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Wakugawa
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Okada
mesh_terms: D000368:Aged; D001562:Benzimidazoles / Q000008:administration & dosage*; D020520:Brain Infarction / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D000069604:Dabigatran; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D065427:Factor Xa Inhibitors / Q000008:administration & dosage; D005343:Fibrinolytic Agents / Q000008:administration & dosage; D006801:Humans; D008297:Male; D010314:Partial Thromboplastin Time; D011355:Prodrugs; D011725:Pyridines / Q000008:administration & dosage*; D011994:Recombinant Proteins / Q000008:administration & dosage; D015912:Thrombolytic Therapy / Q000379:methods*; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*
chemical_list: D001562:Benzimidazoles; D065427:Factor Xa Inhibitors; D005343:Fibrinolytic Agents; D011355:Prodrugs; D011725:Pyridines; D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator; D000069604:Dabigatran