title: Modulation of electrocortical brain activity by attention in individuals with and without tinnitus.
abstract: Age and hearing-level matched tinnitus and control groups were presented with a 40 Hz AM sound using a carrier frequency of either 5 kHz (in the tinnitus frequency region of the tinnitus subjects) or 500 Hz (below this region). On attended blocks subjects pressed a button after each sound indicating whether a single 40 Hz AM pulse of variable increased amplitude (target, probability 0.67) had or had not occurred. On passive blocks subjects rested and ignored the sounds. The amplitude of the 40 Hz auditory steady-state response (ASSR) localizing to primary auditory cortex (A1) increased with attention in control groups probed at 500 Hz and 5 kHz and in the tinnitus group probed at 500 Hz, but not in the tinnitus group probed at 5 kHz (128 channel EEG). N1 amplitude (this response localizing to nonprimary cortex, A2) increased with attention at both sound frequencies in controls but at neither frequency in tinnitus. We suggest that tinnitus-related neural activity occurring in the 5 kHz but not the 500 Hz region of tonotopic A1 disrupted attentional modulation of the 5 kHz ASSR in tinnitus subjects, while tinnitus-related activity in A1 distributing nontonotopically in A2 impaired modulation of N1 at both sound frequencies.
authors.affiliation: Department of Psychology, Neuroscience & Behaviour, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1.
authors.forename: Brandon T
authors.initials: BT
authors.lastname: Paul
authors.affiliation: Department of Psychology, Neuroscience & Behaviour, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1 ; Department of Electrical and Computer Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1 ; McMaster Institute for Music and the Mind, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1.
authors.forename: Ian C
authors.initials: IC
authors.lastname: Bruce
authors.affiliation: Department of Psychology, Neuroscience & Behaviour, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1 ; McMaster Institute for Music and the Mind, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Bosnyak
authors.affiliation: Department of Psychology, Neuroscience & Behaviour, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1.
authors.forename: David C
authors.initials: DC
authors.lastname: Thompson
authors.affiliation: Department of Psychology, Neuroscience & Behaviour, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1 ; McMaster Institute for Music and the Mind, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1.
authors.forename: Larry E
authors.initials: LE
authors.lastname: Roberts
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology; D001288:Attention / Q000502:physiology*; D001299:Audiometry; D001303:Auditory Cortex / Q000502:physiology; D001309:Auditory Threshold / Q000502:physiology; D001921:Brain / Q000503:physiopathology*; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011597:Psychomotor Performance / Q000502:physiology; D014012:Tinnitus / Q000503:physiopathology*; D055815:Young Adult