title: Prediction of infarct severity from triiodothyronine levels in patients with ST-elevation myocardial infarction.
abstract: OBJECTIVE
  The aim of the present study was to evaluate the relationship between thyroid hormone levels and infarct severity in patients with ST-elevation myocardial infarction (STEMI).
  
  
  METHODS
  We retrospectively reviewed thyroid hormone levels, infarct severity, and the extent of transmurality in 40 STEMI patients evaluated via contrast-enhanced cardiac magnetic resonance imaging.
  
  
  RESULTS
  The high triiodothyronine (T3) group (≥ 68.3 ng/dL) exhibited a significantly higher extent of transmural involvement (late transmural enhancement > 75% after administration of gadolinium contrast agent) than did the low T3 group (60% vs. 15%; p = 0.003). However, no significant difference was evident between the high- and low-thyroid-stimulating hormone/free thyroxine (FT4) groups. When the T3 cutoff level was set to 68.3 ng/dL using a receiver operating characteristic curve, the sensitivity was 80% and the specificity 68% in terms of differentiating between those with and without transmural involvement. Upon logistic regression analysis, high T3 level was an independent predictor of transmural involvement after adjustment for the presence of diabetes mellitus (DM) and the use of glycoprotein IIb/IIIa inhibitors (odds ratio, 40.62; 95% confidence interval, 3.29 to 502; p = 0.004).
  
  
  CONCLUSIONS
  The T3 level predicted transmural involvement that was independent of glycoprotein IIb/IIIa inhibitor use and DM positivity.
authors.affiliation: Department of Radiology, Chosun University School of Medicine, Gwangju, Korea.
authors.forename: Dong Hun
authors.initials: DH
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Chosun University School of Medicine, Gwangju, Korea.
authors.forename: Dong-Hyun
authors.initials: DH
authors.lastname: Choi
authors.affiliation: Department of Internal Medicine, Chosun University School of Medicine, Gwangju, Korea.
authors.forename: Hyun-Wook
authors.initials: HW
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Chosun University School of Medicine, Gwangju, Korea.
authors.forename: Seo-Won
authors.initials: SW
authors.lastname: Choi
authors.affiliation: Department of Internal Medicine, Chosun University School of Medicine, Gwangju, Korea.
authors.forename: Bo-Bae
authors.initials: BB
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Chosun University School of Medicine, Gwangju, Korea.
authors.forename: Joong-Wha
authors.initials: JW
authors.lastname: Chung
authors.affiliation: Department of Internal Medicine, Chosun University School of Medicine, Gwangju, Korea.
authors.forename: Young-Youp
authors.initials: YY
authors.lastname: Koh
authors.affiliation: Department of Internal Medicine, Chosun University School of Medicine, Gwangju, Korea.
authors.forename: Kyong-Sig
authors.initials: KS
authors.lastname: Chang
authors.affiliation: Department of Internal Medicine, Chosun University School of Medicine, Gwangju, Korea.
authors.forename: Soon-Pyo
authors.initials: SP
authors.lastname: Hong
mesh_terms: D000368:Aged; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D003287:Contrast Media; D017023:Coronary Angiography; D005260:Female; D006801:Humans; D016015:Logistic Models; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D009206:Myocardium / Q000473:pathology*; D016017:Odds Ratio; D011237:Predictive Value of Tests; D012372:ROC Curve; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood*
chemical_list: D015415:Biomarkers; D003287:Contrast Media; D014284:Triiodothyronine; D013974:Thyroxine
keywords: Magnetic resonance imaging; Myocardial infarction; Triiodothyronine