title: Confronting the challenges of discovery of novel antibacterial agents.
abstract: Bacterial resistance is inevitable and is a growing concern. It can be addressed only by discovery and development of new agents. However the discovery and development of new antibacterial agents are at an all time low. This article broadly examines the historical as well as current status of antibacterial discovery and provides some perspective as how to address some of the challenges.
authors.affiliation: SBS Pharma Consulting LLC, Edison, NJ 08820, United States. Electronic address: sheo.singh.215@gmail.com.
authors.forename: Sheo B
authors.initials: SB
authors.lastname: Singh
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D055808:Drug Discovery; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure
chemical_list: D000900:Anti-Bacterial Agents
keywords: Antibacterial; Antimicrobial; Discovery strategy; Phenotypic screening; Topoisomerase II