title: Erythematosus plaques with macrophage infiltration as an initial manifestation of macrophage activation syndrome in a patient with systemic lupus erythematosus.
abstract: The diagnosis of macrophage activation syndrome (MAS) in patients with systemic lupus erythematosus (SLE) may be challenging as it can mimic the clinical features of the underlying disease or be confused with an infectious complication. In this report, a Japanese woman in her forties had diverse clinical features of MAS at initial presentation of SLE, where erythematosus plaques with histiocytic infiltrates focally surrounding degenerated collagen might be the earliest indicator of MAS.
authors.affiliation: a Institute of Rheumatology, Tokyo Women's Medical University , Shinjuku-ku , Tokyo , Japan.
authors.forename: Mari
authors.initials: M
authors.lastname: Tochihara
authors.affiliation: b Department of Dermatology , Tokyo Women's Medical University , Shinjuku-ku , Tokyo , Japan.
authors.forename: Mikiko
authors.initials: M
authors.lastname: Kasai
authors.affiliation: a Institute of Rheumatology, Tokyo Women's Medical University , Shinjuku-ku , Tokyo , Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Katsumata
authors.affiliation: a Institute of Rheumatology, Tokyo Women's Medical University , Shinjuku-ku , Tokyo , Japan.
authors.forename: Eri
authors.initials: E
authors.lastname: Sato
authors.affiliation: b Department of Dermatology , Tokyo Women's Medical University , Shinjuku-ku , Tokyo , Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Ishiguro
authors.affiliation: c Department of Hematology , Tokyo Women's Medical University , Shinjuku-ku , Tokyo , Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kazama
authors.affiliation: a Institute of Rheumatology, Tokyo Women's Medical University , Shinjuku-ku , Tokyo , Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Sugimoto
authors.affiliation: a Institute of Rheumatology, Tokyo Women's Medical University , Shinjuku-ku , Tokyo , Japan.
authors.forename: Hisae
authors.initials: H
authors.lastname: Ichida
authors.affiliation: a Institute of Rheumatology, Tokyo Women's Medical University , Shinjuku-ku , Tokyo , Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kawaguchi
authors.affiliation: a Institute of Rheumatology, Tokyo Women's Medical University , Shinjuku-ku , Tokyo , Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Yamanaka
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000473:pathology; D055501:Macrophage Activation Syndrome / Q000150:complications / Q000473:pathology*; D008264:Macrophages / Q000473:pathology*
keywords: Hemophagocytic syndrome; Macrophage activation syndrome; Systemic lupus erythematosus