title: Sulforaphane ameliorates neurobehavioral deficits and protects the brain from amyloid β deposits and peroxidation in mice with Alzheimer-like lesions.
abstract: Alzheimer's disease (AD) is a common neurodegenerative disease in the elderly individuals and its effective therapies are still unavailable. This study was designed to investigate the neuroprotection of sulforaphane (SFN) in AD-lesion mice induced by combined administration of d-galactose and aluminium. Results showed that SFN ameliorated spatial cognitive impairment and locomotor activity decrease in Morris water maze and open field test, respectively. And attenuated numbers of amyloid β (Aβ) plaques in both hippocampus and cerebral cortex of AD-lesion mice were detected by immunohistochemistry. According to spectrophotometry and quantitative reverse-transcriptase polymerase chain reaction results, a significant increase in carbonyl group level and obvious decreases in both activity and messenger RNA expression of glutathione peroxidase were found in brain of AD-lesion mice compared with control, but not in SFN-treated AD-lesion mice. In conclusion, SFN ameliorates neurobehavioral deficits and protects the brain from Aβ deposits and peroxidation in mice with Alzheimer-like lesions, suggesting SFN is likely a potential phytochemical to be used in AD therapeutics.
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang 110001, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang 110001, China.
authors.forename: Qian-Wei
authors.initials: QW
authors.lastname: Miao
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang 110001, China.
authors.forename: Chun-Xiao
authors.initials: CX
authors.lastname: Zhu
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang 110001, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang 110001, China.
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang 110001, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang 110001, China anli@mail.cmu.edu.cn.
authors.forename: Li
authors.initials: L
authors.lastname: An
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000517:prevention & control; D016229:Amyloid beta-Peptides / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D017879:Isothiocyanates / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D058225:Plaque, Amyloid / Q000188:drug therapy* / Q000378:metabolism; D011897:Random Allocation; D013454:Sulfoxides
chemical_list: D016229:Amyloid beta-Peptides; D017879:Isothiocyanates; D018696:Neuroprotective Agents; D013454:Sulfoxides; C016766:sulforaphane
keywords: Alzheimer’s disease; amyloid β; neurobehavior; oxidative stress; phytochemical; sulforaphane