title: Remarkable regression of a lung recurrence from an undifferentiated embryonal sarcoma of the liver treated with a DC vaccine combined with immune cells: a case report.
abstract: Undifferentiated embryonal sarcoma of the liver (UESL) is a rare malignant tumor that occurs predominantly in children and has a poor prognosis. Here, we report a novel case in which the UESL presented in the left lobe of the liver and metastasized into both lungs after surgical resection. The patient recovered after our administration of an immunotherapeutic combination of DCs (Dendritic Cells) and multi-immune cells, such as cytokine-induced killer cells (CIKs) and natural killer cells (NKs). After the third cycle of immunotherapy, a CT scan showed a remarkable regression of the lung metastases. This finding supports the conclusion that the DC-based treatment is a promising potential strategy for treating patients with relapsed UESL.
authors.affiliation: Department of R&D, Shanghai Claison Bio-tech Co., Ltd, Shanghai 201201, China.
authors.forename: Shangyun
authors.initials: S
authors.lastname: Xie
authors.affiliation: Department of R&D, Shanghai Claison Bio-tech Co., Ltd, Shanghai 201201, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of R&D, Shanghai Claison Bio-tech Co., Ltd, Shanghai 201201, China; Bio-therapic Treatment Center, Department of Oncology, Chinese Armed Police General Shan Dong Hospital, Shangdong, Jinan 250014, China.
authors.forename: Guoliang
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Department of R&D, Shanghai Claison Bio-tech Co., Ltd, Shanghai 201201, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Xu
authors.affiliation: Bio-therapic Treatment Center, Department of Oncology, Chinese Armed Police General Shan Dong Hospital, Shangdong, Jinan 250014, China.
authors.forename: Xiaoshan
authors.initials: X
authors.lastname: Bian
authors.affiliation: Affiliated Haikou Hospital, Xiangya School of Medicine Central South University, Haikou Municipal People's Hospital, Haikou, China.
authors.forename: Shufang
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of R&D, Shanghai Claison Bio-tech Co., Ltd, Shanghai 201201, China. Electronic address: yongqing.ye@claison.com.
authors.forename: Yongqing
authors.initials: Y
authors.lastname: Ye
mesh_terms: D019496:Cancer Vaccines / Q000627:therapeutic use*; D002648:Child; D055612:Cytokine-Induced Killer Cells / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D008113:Liver Neoplasms / Q000473:pathology*; D008175:Lung Neoplasms / Q000556:secondary / Q000628:therapy*; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000556:secondary / Q000628:therapy; D012509:Sarcoma / Q000556:secondary / Q000628:therapy*; D014611:Vaccination / Q000379:methods*
chemical_list: D019496:Cancer Vaccines
keywords: CIKs; DCs; Immunotherapy; NKs