title: [Metabolic profiling of human blood].
abstract: Metabolomics is a novel "omics" branch of science intended for studying a comprehensive set of low molecular weight substances (metabolites) of various biological objects. Metabolite profiles represent a molecular phenotype of biological systems and reflect information encoded at the genome level and realized at the transcriptome and proteome levels. Analysis of human blood metabolic profile is universal and promising tool for clinical applications because it is a sensitive measure of both endogenous and exogenous (environmental) factors affected on the patient's organism. Technical implementation of metabolic profiling of blood and statistic analysis of metabolite profiles for effective diagnostics and risk assessments of diseases are discussed in this review.
authors.forename: O P
authors.initials: OP
authors.lastname: Trifonova
authors.forename: P G
authors.initials: PG
authors.lastname: Lokhov
authors.forename: A I
authors.initials: AI
authors.lastname: Archakov
mesh_terms: D015415:Biomarkers / Q000097:blood; D015870:Gene Expression; D015894:Genome, Human; D006801:Humans; D013058:Mass Spectrometry; D055442:Metabolome; D055432:Metabolomics; D010641:Phenotype; D011237:Predictive Value of Tests; D020543:Proteome; D012372:ROC Curve; D018570:Risk Assessment; D059467:Transcriptome
chemical_list: D015415:Biomarkers; D020543:Proteome
keywords: blood plasma/serum; mass-spectrometry; metabolite profile; metabolomics