title: Subcellular localization of KL-6 mucin in intraductal papillary mucinous neoplasm of the pancreas.
abstract: This study aimed to clarify the expression profile of KL-6 mucin in intraductal papillary mucinous neoplasm (IPMN) and its relation to tumor malignancy. Expression of KL-6 mucin in 38 IPMNs (intraductal papillary mucinous adenoma (IPMA), 24 cases; minimally invasive intraductal papillary mucinous carcinoma (MI-IPMC), 8 cases; invasive carcinoma originating from IPMC (IC-IPMC), 6 cases) and 66 pancreatic ductal adenocarcinomas (PDACs) was evaluated immunohistochemically. IC-IPMCs and MI-IPMCs had positive staining of KL-6 mucin whereas 58% of IPMAs tested negative. Subcellular localization of KL-6 mucin varied among IPMNs whereas all of the PDAC had positive expression in the circumferential membrane and cytoplasm of cancer cells. IC-IPMCs and MI-IPMCs had a higher frequency of circumferential membrane and cytoplasmic localization of KL-6 mucin than did IPMAs. These results suggest that localization of KL-6 mucin could be used to predict the malignancy of IPMN.
authors.affiliation: Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, the University of Tokyo.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Inagaki
authors.forename: Yasuji
authors.initials: Y
authors.lastname: Seyama
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Hasegawa
authors.forename: Wei
authors.initials: W
authors.lastname: Tang
authors.forename: Norihiro
authors.initials: N
authors.lastname: Kokudo
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000737:chemistry*; D000231:Adenocarcinoma, Papillary / Q000737:chemistry*; D000328:Adult; D000368:Aged; D021441:Carcinoma, Pancreatic Ductal / Q000737:chemistry*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D018396:Mucin-1 / Q000032:analysis*; D010190:Pancreatic Neoplasms / Q000737:chemistry*; D013347:Subcellular Fractions / Q000737:chemistry
chemical_list: C060192:MUC1 protein, human; D018396:Mucin-1