title: The effects of carbamazepine on prefrontal activation in manic youth with bipolar disorder.
abstract: This preliminary study investigated the neurofunctional effects of carbamazepine-extended release (XR) treatment in 11 manic youth with bipolar disorder during performance of a sustained attention task, the Continuous Performance Task - Identical Pairs version (CPT-IP), during functional magnetic resonance imaging (fMRI). All patients underwent baseline fMRI, and 10 patients were scanned again at endpoint. Nine demographically matched healthy youth, who were scanned once, served as controls. Carbamazepine-XR treatment was associated with normalization of activation in right Brodmann area 10 (BA). These results suggest that carbamazepine-XR treatment may correct prefrontal dysfunction in adolescent mania.
authors.affiliation: Medical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Graduate Program in Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
authors.forename: Marguerite Reid
authors.initials: MR
authors.lastname: Schneider
authors.affiliation: Division of Bipolar Disorders Research, Department of Psychiatry & Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
authors.forename: Christina C
authors.initials: CC
authors.lastname: Klein
authors.affiliation: Division of Bipolar Disorders Research, Department of Psychiatry & Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
authors.forename: Wade
authors.initials: W
authors.lastname: Weber
authors.affiliation: Division of Bipolar Disorders Research, Department of Psychiatry & Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
authors.forename: Samantha M
authors.initials: SM
authors.lastname: Bitter
authors.affiliation: Division of Bipolar Disorders Research, Department of Psychiatry & Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
authors.forename: Kimberly B
authors.initials: KB
authors.lastname: Elliott
authors.affiliation: Division of Bipolar Disorders Research, Department of Psychiatry & Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Center for Imaging Research, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Strakowski
authors.affiliation: Division of Bipolar Disorders Research, Department of Psychiatry & Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Center for Imaging Research, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
authors.forename: Caleb M
authors.initials: CM
authors.lastname: Adler
authors.affiliation: Division of Bipolar Disorders Research, Department of Psychiatry & Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address: melissa.delbello@uc.edu.
authors.forename: Melissa P
authors.initials: MP
authors.lastname: DelBello
mesh_terms: D000293:Adolescent; D018692:Antimanic Agents / Q000494:pharmacology*; D001288:Attention / Q000187:drug effects; D001714:Bipolar Disorder; D002220:Carbamazepine / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D017397:Prefrontal Cortex / Q000187:drug effects* / Q000503:physiopathology*; D013647:Task Performance and Analysis
chemical_list: D018692:Antimanic Agents; D002220:Carbamazepine
keywords: Adolescents; Functional magnetic resonance imaging (fMRI); Mania