title: Matrix metalloproteinase-9 (mmp-9) expression in different subtypes of ameloblastoma.
abstract: BACKGROUND
  Ameloblastoma is a common benign odontogenic tumor of the jaw with a local invasive and highly destructive behavior and can develop in any age, with peak prevalence in 3rd-4th decade. Ameloblastoma can be divided into six histological types: follicular, plexiform, acanthomatous, desmoplastic, granular, and basal cell. Matrix metalloproteinase-9 (MMP-9) (92-kD gelatinase/type IV collagenases = gelatinase B) is involved in bone resorption by degradation of extracellular matrix and osteoclasts recruitment. Recent studies have found that MMP-9 is expressed by ameloblastoma and has a role in ameloblastoma local invasiveness.
  
  
  OBJECTIVE
  To analyze MMP-9 expression between different histological types of ameloblastoma.
  
  
  METHODS
  Forty samples of ameloblastoma were collected through consecutive sampling and the MMP-9 expression was detected using immunohistochemistry.
  
  
  RESULTS
  All samples showed positive MMP-9 expression with moderate to strong intensity. 82.4 % plexiform type and 83.3 % mixed type have strong immunoexpression, significantly different with follicular type with only 36.4 % (P < 0.05).
  
  
  CONCLUSIONS
  Ameloblastoma plexiform and mixed type have higher MMP-9 expression than ameloblastoma follicular type. Different MMP-9 expression may contribute in different ameloblastoma biological behavior.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, 10430 Indonesia.
authors.forename: Rachmitha
authors.initials: R
authors.lastname: Anne
authors.affiliation: Department of Pathological Anatomy, Faculty of Medicine, University of Indonesia, Jl. Salemba Raya No. 6, Jakarta Pusat, 10430 Indonesia.
authors.forename: Ening
authors.initials: E
authors.lastname: Krisnuhoni
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, 10430 Indonesia.
authors.forename: Chusnul
authors.initials: C
authors.lastname: Chotimah
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, 10430 Indonesia.
authors.forename: Benny Sjarief
authors.initials: BS
authors.lastname: Latief
keywords: Ameloblastoma; Histological subtypes; Local invasion; MMP-9