title: Decreased blood transfusion following revision total knee arthroplasty using tranexamic acid.
abstract: Tranexamic acid (TXA) has been used successfully in primary total knee arthroplasty (TKA) to minimize blood loss and transfusions. The purpose of this study is to determine its efficacy in patients undergoing revision TKA. In a retrospective review of 111 patients (68 control and 43 TXA), treatment patients receiving a single intravenous TXA dose of 10mg/kg required less transfusions (P=0.03) and less total blood units consumed than controls (P=0.03). When stratified by type of revision, treatment patients undergoing femoral and tibial component revision had lower transfusion rates than the controls (P=0.03). Given the drawbacks of allogenic blood transfusion, we highly recommend the use of TXA in revision TKA, especially when both components are being revised.
authors.affiliation: University of Louisville, KentuckyOne Health, Louisville, Kentucky.
authors.forename: Christopher
authors.initials: C
authors.lastname: Samujh
authors.affiliation: University of Louisville, KentuckyOne Health, Louisville, Kentucky.
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Falls
authors.affiliation: University of Louisville, KentuckyOne Health, Louisville, Kentucky.
authors.forename: Robert
authors.initials: R
authors.lastname: Wessel
authors.affiliation: University of Louisville, KentuckyOne Health, Louisville, Kentucky.
authors.forename: Langan
authors.initials: L
authors.lastname: Smith
authors.affiliation: University of Louisville, KentuckyOne Health, Louisville, Kentucky.
authors.forename: Arthur L
authors.initials: AL
authors.lastname: Malkani
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000933:Antifibrinolytic Agents / Q000008:administration & dosage*; D019645:Arthroplasty, Replacement, Knee / Q000379:methods*; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D001803:Blood Transfusion / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014148:Tranexamic Acid / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid
keywords: blood transfusion; intraoperative blood loss; post operative anemia; revision total knee arthroplasty; tranexamic acid