title: Spatiotemporal patterns of current source density in the prefrontal cortex of a behaving monkey.
abstract: One of the fundamental missions of neuroscience is to explore the input and output properties of neuronal networks to reveal their functional significance. However, it is technically difficult to examine synaptic inputs into neuronal circuits in behaving animals. Here, we conducted current source density (CSD) analysis on local field potentials (LFPs) recorded simultaneously using a multi-contact electrode in the prefrontal cortex (PFC) of a behaving monkey. We observed current sink task-dependent spatiotemporal patterns considered to reflect the synaptic input to neurons adjacent to the recording site. Specifically, the inferior convex current sink in the PFC was dominant during the delay period, whereas the current sink was prominent in the principal sulcus during the sample cue and test cue periods. Surprisingly, sulcus current sink patterns were spatially periodic, which corresponds to the columnar structure suggested by previous anatomical studies. The approaches used in the current study will help to elucidate how the PFC network performs executive functions according to its synaptic input.
authors.affiliation: Research Institute of Electrical Communication, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan. Electronic address: sakamoto@riec.tohoku.ac.jp.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Sakamoto
authors.affiliation: Department of Physiology, Tohoku University School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai 980-8575, Japan.
authors.forename: Norihiko
authors.initials: N
authors.lastname: Kawaguchi
authors.affiliation: Department of Physiology, Tohoku University School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai 980-8575, Japan.
authors.forename: Kohei
authors.initials: K
authors.lastname: Yagi
authors.affiliation: Department of Physiology, Tohoku University School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai 980-8575, Japan; The Core Research for Evolutional Science and Technology Program (CREST), JST, Goban-cho, Chiyoda-ku, Tokyo, 102-0076, Japan.
authors.forename: Hajime
authors.initials: H
authors.lastname: Mushiake
mesh_terms: D000465:Algorithms; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D003463:Cues; D055724:Electrophysiological Phenomena; D005071:Evoked Potentials / Q000502:physiology; D008251:Macaca; D008297:Male; D009415:Nerve Net / Q000166:cytology / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D017397:Prefrontal Cortex / Q000502:physiology*; D013569:Synapses / Q000502:physiology
keywords: Current source density analysis; Local field potential; Prefrontal cortex