title: Facile and mild synthesis of linear and cyclic peptides via thioesters.
abstract: Thioester-mediated peptide bond formation has recently garnered a lot of attention, most notably in its relevance to condensation of large peptide fragments. Herein, a simple and general ligation method for the preparation of linear and cyclic peptides, starting from peptide thioester, mainly p-chlorophenyl, precursors is reported. The inherent advantages of this method are the low epimerization, reduced dimerization, use of mild reaction conditions, and elimination of superfluous coupling reagents.
authors.affiliation: Novartis Institutes for BioMedical Research, Novartis Pharma AG , Forum 1, Novartis Campus, CH-4056 Basel, Switzerland.
authors.forename: Paola
authors.initials: P
authors.lastname: Agrigento
authors.forename: Fernando
authors.initials: F
authors.lastname: Albericio
authors.forename: Sylvie
authors.initials: S
authors.lastname: Chamoin
authors.forename: Isabelle
authors.initials: I
authors.lastname: Dacquignies
authors.forename: Halil
authors.initials: H
authors.lastname: Koc
authors.forename: Martin
authors.initials: M
authors.lastname: Eberle
mesh_terms: D004952:Esters; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D013457:Sulfur Compounds / Q000737:chemistry*
chemical_list: D004952:Esters; D010455:Peptides; D010456:Peptides, Cyclic; D013457:Sulfur Compounds