title: Cutaneous reactions to chemotherapeutic drugs and targeted therapies for cancer: part I. Conventional chemotherapeutic drugs.
abstract: Conventional chemotherapy continues to be an important part of cancer management, but may cause various cutaneous reactions because it disturbs specific cell cycle phases. The alkylating agents cyclophosphamide, ifosfamide, and thiotepa can produce hyperpigmentation, while hypersensitivity reactions can be seen with platinum alkylating agents. Antimetabolites vary in reactions from exanthematous to bullous skin lesions. 5-fluorouracil and its derivatives and liposomal doxorubicin and daunorubicin are characteristically known to cause hand-foot syndrome, while bleomycin can cause fibrosis and flagellate dermatitis. Several hypersensitivity reactions may also occur from mitotic inhibitors and topoisomerase inhibitors. These different characteristic presentations are important to dermatologists in identifying the correct diagnosis and management for the cancer patient.
authors.affiliation: Los Banos Doctors Hospital and Medical Center, Los Banos, Laguna, Philippines.
authors.forename: Claire Marie
authors.initials: CM
authors.lastname: Reyes-Habito
authors.affiliation: Harvard Medical School and Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts. Electronic address: ekroh@partners.org.
authors.forename: Ellen K
authors.initials: EK
authors.lastname: Roh
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000009:adverse effects; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000009:adverse effects*; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects; D003875:Drug Eruptions / Q000209:etiology* / Q000628:therapy; D004502:Education, Medical, Continuing; D006801:Humans; D017495:Hyperpigmentation / Q000139:chemically induced
chemical_list: D000903:Antibiotics, Antineoplastic; D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D018906:Antineoplastic Agents, Alkylating; D000972:Antineoplastic Agents, Phytogenic
keywords: cancer; chemotherapy; cutaneous reactions; cytotoxic therapy; drug hypersensitivity; rash