title: Regiospecific synthesis of 2-halo-3-(2'-glucalyl)benzo[b]thiophenes.
abstract: A regiospecific synthetic strategy for the synthesis of 2-chloro-3-substituted benzo[b]thiophenes is developed via a dichlorocarbene insertion and sigmatropic rearrangement of an in situ generated ylide. The current protocol provides a reversed regiochemistry to the commonly employed electrophilic cyclization reaction for the synthesis of benzo[b]thiophenes and access to their hitherto under-represented chlorinated derivatives.
authors.affiliation: Department of Chemistry, University of Johannesburg , P.O. Box 524, Auckland Park 2006, Republic of South Africa.
authors.forename: Henok H
authors.initials: HH
authors.lastname: Kinfe
authors.forename: Felix L
authors.initials: FL
authors.lastname: Makolo
authors.forename: Christian K
authors.initials: CK
authors.lastname: Adokoh