title: Thiol modification by bioactivated polyphenols and its potential role in skin inflammation.
abstract: In the present study, we evaluated the modifying behavior of simple phenolic compounds on the sulfhydryl groups of glutathione and proteins. The catechol-type polyphenols, including protocatechuic acid, but neither the monophenols nor O-methylated catechol, can modify the sulfhydryl groups in a phenol oxidase-dependent manner. The possible involvement of polyphenol bioactivation in the enhancement of skin inflammation was also suggested.
authors.affiliation: a Graduate School of Environmental and Life Science , Okayama University , Okayama , Japan.
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ishii
authors.forename: Naomi
authors.initials: N
authors.lastname: Abe
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Murata
mesh_terms: D000818:Animals; D005260:Female; D005978:Glutathione / Q000378:metabolism; D007249:Inflammation / Q000201:enzymology / Q000378:metabolism; D051379:Mice; D014442:Monophenol Monooxygenase / Q000378:metabolism; D059808:Polyphenols / Q000737:chemistry* / Q000378:metabolism*; D012871:Skin Diseases / Q000201:enzymology / Q000378:metabolism*; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D059808:Polyphenols; D013438:Sulfhydryl Compounds; D014442:Monophenol Monooxygenase; D005978:Glutathione
keywords: glutathione; polyphenol; protein thiols; skin inflammation; tyrosinase