title: 6-iodolactone, key mediator of antitumoral properties of iodine.
abstract: An iodinated derivative of arachidonic acid, 5-hydroxy-6-iodo-8,11,14-eicosatrienoic acid, δ-lactone (6-IL) has been implicated as a possible intermediate in the autoregulation of the thyroid gland by iodine. In addition to antiproliferative and apoptotic effects observed in thyrocytes, this iodolipid could also exert similar actions in cells derived from extrathyroidal tissues like mammary gland, prostate, colon, or the nervous system. In mammary cancer (solid tumors or tumor cell lines), 6-IL has been detected after molecular iodine (I2) supplement, and is a potent activator of peroxisome proliferator-activated receptor type gamma (PPARγ). These observations led us to propose I2 supplement as a novel coadjutant therapy which, by inducing differentiation mechanisms, decreases tumor progression and prevents chemoresistance. Some kinds of tumoral cells, in contrast to normal cells, contain high concentrations of arachidonic acid, making the I2 supplement a potential "magic bullet" that enables local, specific production of 6-IL, which then exerts antineoplastic actions with minimal deleterious effects on normal tissues.
authors.affiliation: Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus Juriquilla, Querétaro, Mexico. Electronic address: marionava23@unam.mx.
authors.forename: Mario
authors.initials: M
authors.lastname: Nava-Villalba
authors.affiliation: Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus Juriquilla, Querétaro, Mexico. Electronic address: caracev@unam.mx.
authors.forename: Carmen
authors.initials: C
authors.lastname: Aceves
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents; D017209:Apoptosis / Q000187:drug effects; D016718:Arachidonic Acid / Q000032:analysis / Q000737:chemistry; D001095:Arachidonic Acids / Q000096:biosynthesis / Q000494:pharmacology* / Q000502:physiology; D049109:Cell Proliferation / Q000187:drug effects; D005260:Female; D006801:Humans; D007455:Iodine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009369:Neoplasms / Q000737:chemistry / Q000188:drug therapy; D047495:PPAR gamma / Q000187:drug effects / Q000502:physiology; D013961:Thyroid Gland / Q000187:drug effects / Q000502:physiology
chemical_list: C026915:6-iodo-5-hydroxy-eicosatrienoic acid, delta-lactone; D000970:Antineoplastic Agents; D001095:Arachidonic Acids; D047495:PPAR gamma; D016718:Arachidonic Acid; D007455:Iodine
keywords: Apoptosis; Arachidonic acid; Iodine; Iodocompounds; Iodolipids; Mammary cancer