title: Recent advances on the development of magnesium alloys for biodegradable implants.
abstract: In recent years, much progress has been made on the development of biodegradable magnesium alloys as "smart" implants in cardiovascular and orthopedic applications. Mg-based alloys as biodegradable implants have outstanding advantages over Fe-based and Zn-based ones. However, the extensive applications of Mg-based alloys are still inhibited mainly by their high degradation rates and consequent loss in mechanical integrity. Consequently, extensive studies have been conducted to develop Mg-based alloys with superior mechanical and corrosion performance. This review focuses on the following topics: (i) the design criteria of biodegradable materials; (ii) alloy development strategy; (iii) in vitro performances of currently developed Mg-based alloys; and (iv) in vivo performances of currently developed Mg-based implants, especially Mg-based alloys under clinical trials.
authors.affiliation: ERC for Revolutionizing Metallic Biomaterials, North Carolina A&T State University, Greensboro, NC 27411, USA. Electronic address: happywinner01@gmail.com.
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Chen
authors.affiliation: ERC for Revolutionizing Metallic Biomaterials, North Carolina A&T State University, Greensboro, NC 27411, USA.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Xu
authors.affiliation: ERC for Revolutionizing Metallic Biomaterials, North Carolina A&T State University, Greensboro, NC 27411, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Smith
authors.affiliation: ERC for Revolutionizing Metallic Biomaterials, North Carolina A&T State University, Greensboro, NC 27411, USA.
authors.forename: Jag
authors.initials: J
authors.lastname: Sankar
mesh_terms: D020341:Absorbable Implants / Q000639:trends*; D000497:Alloys / Q000737:chemistry*; D000818:Animals; D008274:Magnesium / Q000737:chemistry*; D009985:Orthopedics; D011474:Prosthesis Design
chemical_list: D000497:Alloys; D008274:Magnesium
keywords: Biodegradable implants; Corrosion; Design strategy; Magnesium alloys; Mechanical properties