title: Estimates of projection overlap and zones of convergence within frontal-striatal circuits.
abstract: Frontal-striatal circuits underlie important decision processes, and pathology in these circuits is implicated in many psychiatric disorders. Studies have shown a topographic organization of cortical projections into the striatum. However, work has also shown that there is considerable overlap in the striatal projection zones of nearby cortical regions. To characterize this in detail, we quantified the complete striatal projection zones from 34 cortical injection locations in rhesus monkeys. We first fit a statistical model that showed that the projection zone of a cortical injection site could be predicted with considerable accuracy using a cross-validated model estimated on only the other injection sites. We then examined the fraction of overlap in striatal projection zones as a function of distance between cortical injection sites, and found that there was a highly regular relationship. Specifically, nearby cortical locations had as much as 80% overlap, and the amount of overlap decayed exponentially as a function of distance between the cortical injection sites. Finally, we found that some portions of the striatum received inputs from all the prefrontal regions, making these striatal zones candidates as information-processing hubs. Thus, the striatum is a site of convergence that allows integration of information spread across diverse prefrontal cortical areas.
authors.affiliation: Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-4415, and bruno.averbeck@nih.gov.
authors.forename: Bruno B
authors.initials: BB
authors.lastname: Averbeck
authors.affiliation: Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642.
authors.forename: Julia
authors.initials: J
authors.lastname: Lehman
authors.affiliation: Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642.
authors.forename: Moriah
authors.initials: M
authors.lastname: Jacobson
authors.affiliation: Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642.
authors.forename: Suzanne N
authors.initials: SN
authors.lastname: Haber
mesh_terms: D000818:Animals; D001931:Brain Mapping; D003342:Corpus Striatum / Q000033:anatomy & histology*; D003911:Dextrans; D005625:Frontal Lobe / Q000033:anatomy & histology*; D021621:Imaging, Three-Dimensional; D007546:Isoquinolines; D008253:Macaca mulatta; D008297:Male; D009415:Nerve Net / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology*; D012235:Rhodamines
chemical_list: D003911:Dextrans; C067661:Fluoro-Ruby; D007546:Isoquinolines; D012235:Rhodamines; C017475:lucifer yellow