title: Experimental study on the effect of electrostimulation on neural regeneration after oculomotor nerve injury.
abstract: The oculomotor nerve can regenerate anatomically and histologically after injury; however, the degree of functional recovery of extraocular muscles and the pupil sphincter muscle was not satisfactory. Electrostimulation was one potential intervention that was increasingly being studied for use in nerve injury settings. However, the effect of electrostimulation on regeneration of the injured oculomotor nerve was still obscure. In this study, we studied the effects of electrostimulation on neural regeneration in terms of neurofunction, myoelectrophysiology, neuroanatomy, and neurohistology after oculomotor nerve injury and found that electrostimulation on the injured oculomotor nerve enhanced the speed and final level of its functional and electrophysiological recovery, promoted neural regeneration, and enhanced the selectivity and specificity of reinnervation of the regenerated neuron, the conformity among the electrophysiological and functional recovery of extraocular muscles, and neural regeneration, and that the function of extraocular muscles recovered slower than electrophysiology. Thus, we speculated that electrostimulation on the injured oculomotor nerve produced a marked effect on all phases of neural regeneration including neuronal survival, sprout formation, axonal elongation, target reconnection, and synaptogenesis. We think that neural electrostimulation can be used in oculomotor nerve injury.
authors.affiliation: Department of Neurosurgery, The Central Hospital of Tai'an, No. 29 Longtan Road, 271000, Tai'an, China, zhuningxi28@163.com.
authors.forename: Ningxi
authors.initials: N
authors.lastname: Zhu
authors.forename: Chunmei
authors.initials: C
authors.lastname: Zhang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Li
authors.forename: Youqiang
authors.initials: Y
authors.lastname: Meng
authors.forename: Baohui
authors.initials: B
authors.lastname: Feng
authors.forename: Xuhui
authors.initials: X
authors.lastname: Wang
authors.forename: Min
authors.initials: M
authors.lastname: Yang
authors.forename: Liang
authors.initials: L
authors.lastname: Wan
authors.forename: Bo
authors.initials: B
authors.lastname: Ning
authors.forename: Shiting
authors.initials: S
authors.lastname: Li
mesh_terms: D000818:Animals; D004285:Dogs; D004599:Electric Stimulation Therapy; D009416:Nerve Regeneration; D009802:Oculomotor Nerve / Q000502:physiology*; D061220:Oculomotor Nerve Injuries / Q000628:therapy*