title: Impact of the 5008 monitor software update on total convective volume.
abstract: BACKGROUND
  On-line haemodiafiltration (OL-HDF) is based on the controlled administration of large volumes of replacement ultrapure dialysate to the extracorporeal blood circuit of dialysis. It is currently the most effective technique for eliminating small and large uraemic toxins. Recent studies have observed a direct association between a decrease in mortality and the received convective volume. The latest Fresenius 5008 (5008 CorDiax) monitor software update enables the automation of the replacement volume without requiring total protein and haematocrit values, with the aim of maximising convection.
  
  
  OBJECTIVE
  The study&rsquo;s objective was to evaluate the recent version of the 5008 monitor software, compared to the previous version, on the impact on total convective volume.
  
  
  METHODS
  We included 63 patients (44 males and 19 females), with a mean age of 65.2&nbsp;&plusmn;&nbsp;15 years, on OL-HDF. Each patient was analysed in 6 sessions; 3 with the 5008 monitor and 3 with the 5008 CorDiax monitor. The replacement volume, total convective volume and dialysis parameters were determined in each session.
  
  
  RESULTS
  No significant differences were observed in blood, venous or transmembrane pressure, nor was there an increase in the number of alarms or coagulation of lines or dialysers. A significant increase of replacement fluid volume, from 27.2 to 31.2&nbsp;L/session, was observed using the CorDiax software. Total convective volume increased from 29.5 to 33.3 L/session, representing an effective convective volume increase from 26&nbsp;% to 29.6&nbsp;% of total filtered blood.
  
  
  CONCLUSIONS
  The 5008 dialysis monitor software update has meant a 13&nbsp;% increase of total convective volume and a 3.5&nbsp;% increase of total filtered blood.
authors.forename: Francisco
authors.initials: F
authors.lastname: Maduell
authors.forename: Néstor
authors.initials: N
authors.lastname: Rodríguez
authors.forename: Laura
authors.initials: L
authors.lastname: Sahdalá
authors.forename: Diego
authors.initials: D
authors.lastname: Coronel
authors.forename: Marta
authors.initials: M
authors.lastname: Arias Guillén
authors.forename: Raquel
authors.initials: R
authors.lastname: Ojeda
authors.forename: Manel
authors.initials: M
authors.lastname: Vera
authors.forename: Néstor
authors.initials: N
authors.lastname: Fontseré
authors.forename: Aleix
authors.initials: A
authors.lastname: Cases
authors.forename: Josep M
authors.initials: JM
authors.lastname: Campistol
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D017583:Hemodiafiltration / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012984:Software