title: Control of cellular motility by neuropilin-mediated physical interactions.
abstract: The neuropilin (Nrp) family consists of multifunctional cell surface receptors with critical roles in a number of different cell and tissue types. A core aspect of Nrp function is in ligand-dependent cellular migration, where it controls the multistep process of cellular motility through integration of ligand binding and receptor signaling. At a molecular level, the role of Nrp in migration is intimately connected to the control of adhesive interactions and cytoskeletal reorganization. Here, we review the physiological role of Nrp in cellular adhesion and motility in the cardiovascular and nervous systems. We also discuss the emerging pathological role of Nrp in tumor cell migration and metastasis, providing motivation for continued efforts toward developing Nrp inhibitors.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Li
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Parker
authors.forename: Craig W
authors.initials: CW
authors.lastname: Vander Kooi
mesh_terms: D000818:Animals; D002319:Cardiovascular System / Q000166:cytology / Q000378:metabolism; D002448:Cell Adhesion; D002465:Cell Movement / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000473:pathology; D009420:Nervous System / Q000166:cytology / Q000378:metabolism; D039921:Neuropilins / Q000378:metabolism*; D039961:Semaphorins / Q000378:metabolism; D015398:Signal Transduction; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D039921:Neuropilins; D039961:Semaphorins; D042461:Vascular Endothelial Growth Factor A