title: Excitability in a stochastic differential equation model for calcium puffs.
abstract: Calcium dynamics are essential to a multitude of cellular processes. For many cell types, localized discharges of calcium through small clusters of intracellular channels are building blocks for all spatially extended calcium signals. Because of the large noise amplitude, the validity of noise-approximating model equations for this system has been questioned. Here we revisit the master equations for local calcium release, examine the multiple scales of calcium concentrations in the cluster domain, and derive adapted stochastic differential equations. We show by comparison of discrete and continuous trajectories that the Langevin equations can be made consistent with the master equations even for very small channel numbers. In its deterministic limit, the model reveals that excitability, a dynamical phenomenon observed in many natural systems, is at the core of calcium puffs. The model also predicts a bifurcation from transient to sustained release which may link local and global calcium signals in cells.
authors.affiliation: Institut für Physik, Humboldt-Universität zu Berlin, 12489 Berlin, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Rüdiger
mesh_terms: D002118:Calcium / Q000737:chemistry / Q000378:metabolism*; D015220:Calcium Channels / Q000737:chemistry / Q000502:physiology*; D020013:Calcium Signaling / Q000502:physiology*; D002462:Cell Membrane / Q000502:physiology*; D003198:Computer Simulation; D008954:Models, Biological; D008956:Models, Chemical; D015233:Models, Statistical; D013269:Stochastic Processes
chemical_list: D015220:Calcium Channels; D002118:Calcium