title: The Efficacy of Propofol vs. Subcutaneous Sumatriptan for Treatment of Acute Migraine Headaches in the Emergency Department: A Double-Blinded Clinical Trial.
abstract: BACKGROUND
  In this double-blinded, randomized trial, we hypothesized that propofol is as effective as sumatriptan in treating acute migraine headaches, with better control of nausea and vomiting, and fewer side effects.
  
  
  METHODS
  Ninety cases of acute migraine attack admitted to the emergency department were randomly allocated into two treatment groups: (1) 6 mg of sumatriptan subcutaneously or (2) propofol injected intravenously in 30 to 40 mg boluses, followed by 10 to 20 mg intermittent bolus doses to sedate the patients to Ramsey score of 3 to 4. Headache severity was assessed using an 11-point visual analog scale before treatment and 30 minutes, 1 hour, and 2 hours after treatment. Accompanying symptoms, improvement in headache, and the need for anti-emetic therapy were also assessed.
  
  
  RESULTS
  A total of 91 patients were enrolled in this study. One patient in the sumatriptan group was excluded due to severe chest tightness, and 90 patients were included in the final analysis. Pain intensity was significantly lower in the propofol group 30 minutes after treatment (P = 0.001); however, after 1 and 2 hours, there were no significant differences between the groups. The need for anti-emetic therapy and the recurrence of symptoms were significantly lower in the propofol group (P = 0.045 and P = 0.001, respectively).
  
  
  CONCLUSIONS
  Propofol is equally suitable as sumatriptan for the acute treatment of migraine headaches in an emergency department setting. Moreover, the use of propofol avoids some of the adverse side effects of sumatriptan while providing better control of nausea and vomiting.
authors.affiliation: Pain Research Center, Department of Anesthesiology and Intensive Care Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Moshtaghion
authors.affiliation: Pain Research Center, Department of Anesthesiology and Intensive Care Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Najmeh
authors.initials: N
authors.lastname: Heiranizadeh
authors.affiliation: Department of Neurology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Abolghasem
authors.initials: A
authors.lastname: Rahimdel
authors.affiliation: Trauma Research Center, Department of Emergency Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Esmaeili
authors.affiliation: Trauma Research Center, Department of Emergency Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Hashemian
authors.affiliation: Department of Laboratory Sciences, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Seyedhossein
authors.initials: S
authors.lastname: Hekmatimoghaddam
mesh_terms: D000328:Adult; D000368:Aged; D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D004311:Double-Blind Method; D004636:Emergency Service, Hospital; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy*; D015742:Propofol / Q000008:administration & dosage* / Q000009:adverse effects; D058825:Serotonin 5-HT1 Receptor Agonists / Q000008:administration & dosage*; D018170:Sumatriptan / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D018686:Anesthetics, Intravenous; D058825:Serotonin 5-HT1 Receptor Agonists; D018170:Sumatriptan; D015742:Propofol
keywords: emergency department; headache; migraine; propofol; sumatriptan; treatment