title: Changing patterns of in-hospital deaths following implementation of damage control resuscitation practices in US forward military treatment facilities.
abstract: OBJECTIVE
  Analysis of combat deaths provides invaluable epidemiologic and quality-improvement data for trauma centers and is particularly important under rapidly evolving battlefield conditions.
  
  
  OBJECTIVE
  To analyze the evolution of injury patterns, early care, and resuscitation among patients who subsequently died in the hospital, before and after implementation of damage control resuscitation (DCR) policies.
  
  
  METHODS
  In a review of the Joint Theater Trauma Registry (2002-2011) of US forward combat hospitals, cohorts of patients with vital signs at presentation and subsequent in-hospital death were grouped into 2 time periods: pre-DCR (before 2006) and DCR (2006-2011).
  
  
  METHODS
  Injury types and Injury Severity Scores (ISSs), timing and location of death, and initial (24-hour) and total volume of blood products and fluid administered.
  
  
  RESULTS
  Of 57,179 soldiers admitted to a forward combat hospital, 2565 (4.5%) subsequently died in the hospital. The majority of patients (74%) were severely injured (ISS > 15), and 80% died within 24 hours of admission. Damage control resuscitation policies were widely implemented by 2006 and resulted in a decrease in mean 24-hour crystalloid infusion volume (6.1-3.2 L) and increased fresh frozen plasma use (3.2-10.1 U) (both P < .05) in this population. The mean packed red blood cells to fresh frozen plasma ratio changed from 2.6:1 during the pre-DCR period to 1.4:1 during the DCR period (P < .01). There was a significant increase in mean ISS between cohorts (pre-DCR ISS = 23 vs DCR ISS = 27; P < .05) and a marked shift in injury patterns favoring more severe head trauma in the DCR cohort.
  
  
  CONCLUSIONS
  There has been a significant shift in resuscitation practices in forward combat hospitals indicating widespread military adoption of DCR. Patients who died in a hospital during the DCR period were more likely to be severely injured and have a severe brain injury, consistent with a decrease in deaths among potentially salvageable patients.
authors.affiliation: Department of Surgery, Madigan Army Medical Center, Tacoma, Washington.
authors.forename: Nicholas R
authors.initials: NR
authors.lastname: Langan
authors.affiliation: Department of Surgery, Madigan Army Medical Center, Tacoma, Washington.
authors.forename: Matthew
authors.initials: M
authors.lastname: Eckert
authors.affiliation: Department of Surgery, Madigan Army Medical Center, Tacoma, Washington.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Martin
mesh_terms: D000328:Adult; D055826:Afghan Campaign 2001-; D001803:Blood Transfusion / Q000379:methods / Q000706:statistics & numerical data; D005260:Female; D017052:Hospital Mortality / Q000639:trends*; D006772:Hospitals, Military / Q000458:organization & administration* / Q000706:statistics & numerical data; D006801:Humans; D054542:Iraq War, 2003-2011; D008297:Male; D008887:Military Medicine / Q000379:methods; D008889:Military Personnel / Q000706:statistics & numerical data*; D017063:Outcome Assessment, Health Care; D012151:Resuscitation / Q000379:methods*; D012771:Shock, Hemorrhagic / Q000628:therapy; D014193:Trauma Centers / Q000458:organization & administration* / Q000706:statistics & numerical data; D015599:Trauma Severity Indices; D014481:United States / Q000453:epidemiology; D014947:Wounds and Injuries / Q000401:mortality* / Q000628:therapy*; D055815:Young Adult