title: Trigonella foenum-graecum protection against deltamethrin-induced toxic effects on haematological, biochemical, and oxidative stress parameters in rats.
abstract: Trigonella foenum-graecum L. is enriched with many active ingredients. TFG oil was evaluated for its protective effect against deltamethrin toxicity in rats. Rats of the control group were administered saline. The 2nd group was administered deltamethrin (DLM) orally at a concentration of 15 mg/kg body mass. The 3rd and 4th groups were administered DLM at a concentration of 15 mg/kg body mass and were fed diets containing 2.5% and 5% TFG oil, respectively. DLM intoxication reduced red blood cell and platelet counts, hemoglobin concentration, and hematocrit value while it induced leucocytosis. Furthermore, it increased serum levels of lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, γ-glutamyltransferase, triglycerides, cholesterol, uric acid, urea, and creatinine; increased hepatic, renal, and brain lipid peroxidation; decreased serum acetylcholine esterase level; and decreased hepatic, renal, and brain antioxidant markers' activities. However, TFG oil kept the studied hematological and biochemical parameters within normal ranges. In addition, it prevented lipid peroxidation and oxidative stress induced by DLM intoxication in a dose-dependent manner. Therefore, these results indicated that TFG oil inhibited the toxic effects of DLM on hematological and biochemical parameters as well as oxidative status by its free radical scavenging and potent antioxidant activities, and it appeared to be a promising protective agent against DLM-induced toxicity.
authors.affiliation: a Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt.
authors.forename: Mohamed M
authors.initials: MM
authors.lastname: Abdel-Daim
authors.forename: Mabrouk A
authors.initials: MA
authors.lastname: Abd Eldaim
authors.forename: Mohamed M
authors.initials: MM
authors.lastname: Mahmoud
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001792:Blood Platelets / Q000166:cytology / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D019610:Cytoprotection; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects; D016166:Free Radical Scavengers / Q000494:pharmacology*; D007306:Insecticides / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009570:Nitriles / Q000633:toxicity*; D018384:Oxidative Stress; D010938:Plant Oils / Q000494:pharmacology*; D011722:Pyrethrins / Q000633:toxicity*; D017208:Rats, Wistar; D029910:Trigonella
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D007306:Insecticides; D009570:Nitriles; D010938:Plant Oils; D011722:Pyrethrins; C017180:decamethrin
keywords: Trigonella foenum-graecum; biochemical changes; changements biochimiques; changements hématologiques; deltamethrin; deltaméthrine; haematological changes; oxidative stress parameters; paramètres du stress oxydant