title: Regioselective conversion of arenes to N-aryl-1,2,3-triazoles using C-H borylation.
abstract: A one-pot protocol for the synthesis of N-aryl 1,2,3-triazoles from arenes by an iridium-catalyzed CH borylation/copper catalyzed azidation/click sequence is described. 1 mol % of Cu(OTf)2 was found to efficiently catalyze both the azidation and the click reaction. The applicability of this method is demonstrated by the late-stage chemoselective installation of 1,2,3-triazole moiety into unactivated molecules of pharmaceutical importance.
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW (UK). chmraja@gmail.com.
authors.forename: Rajavel
authors.initials: R
authors.lastname: Srinivasan
authors.forename: Anthony G
authors.initials: AG
authors.lastname: Coyne
authors.forename: Chris
authors.initials: C
authors.lastname: Abell
keywords: CH borylation; azidation; click chemistry; synthetic methods