title: Insulin resistance is not associated with thermogenic effect of a high-fat meal in obese children.
abstract: In adults, insulin resistance may decrease the thermogenic effect of food, contributing to weight gain. We aimed to determine the effect of insulin resistance on energy expenditure in children with long-standing obesity. We hypothesized that thermogenic effect of food would decrease with increasing insulin resistance. Energy expenditure was measured using whole room indirect calorimetry in obese children 7 to 18 years old. Participants were fed a high-fat meal with energy content equal to 35% of measured resting energy expenditure. Thermogenic effect of food was measured for 180 minutes posttest meal and expressed as a percent of calories consumed. Body composition was assessed using whole-body dual-energy x-ray absorptiometry. Fasting glucose, insulin, and hemoglobin A1C were measured. Complete data were available for 25 children (median age, 12.1 years; 52% male). As expected, a significant decrease in resting energy expenditure was observed with increasing Tanner stage (P = .02 by Kruskal-Wallis test). Insulin sensitivity, as determined by homeostasis model assessment index equation, did not significantly affect resting energy expenditure (P = .3) or thermogenic effect of food (P = .7) after adjustment for Tanner stage. In conclusion, our study did not find an association between insulin resistance and energy expenditure in obese children.
authors.affiliation: School of Medicine, Vanderbilt University, Nashville, TN, USA.
authors.forename: Jeremy
authors.initials: J
authors.lastname: Chan
authors.affiliation: Division of Pediatric Endocrinology, Vanderbilt University, Nashville, TN, USA.
authors.forename: Jefferson P
authors.initials: JP
authors.lastname: Lomenick
authors.affiliation: Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: Maciej S
authors.initials: MS
authors.lastname: Buchowski
authors.affiliation: Division of Pediatric Endocrinology, Vanderbilt University, Nashville, TN, USA. Electronic address: Ashley.H.Shoemaker@vanderbilt.edu.
authors.forename: Ashley H
authors.initials: AH
authors.lastname: Shoemaker
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism; D001823:Body Composition; D015992:Body Mass Index; D002153:Calorimetry, Indirect; D002648:Child; D059305:Diet, High-Fat / Q000009:adverse effects*; D002149:Energy Intake; D004734:Energy Metabolism; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D016014:Linear Models; D008297:Male; D062407:Meals; D063766:Pediatric Obesity / Q000503:physiopathology*; D015430:Weight Gain
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007328:Insulin
keywords: Calorimetry; Energy metabolism; Insulin resistance; Obesity; Pediatrics