title: [Expression and significance of gene Rad52 in nasopharyngeal carcinoma].
abstract: OBJECTIVE
  To investigate the expression and clinical significance of Rad52, a homologous recombination repair gene, in tissues of nasopharyngeal carcinoma (NPC).
  
  
  METHODS
  The expression of Rad52 was detected with three-step immunohistochemistry technique in tissues of 38 NPC patients and which have the corresponding paracancerous tissues. All of the Rad52 expression and clinical data (gender, age, clinical stage ) were compared and analyzed to conclude the relationship between them.
  
  
  RESULTS
  The Rad52 expressions were significantly different from NPC tissues to peri-NPC tissues (P < 0.05). It was found by Spearman analysis method that the Rad52 expression decreased with patients'clinical stages (P < 0.05), but has no significant relationship with gender, age, recurrence, and lymphonode metastasis (P > 0.05). The expression of Rad52 influenced the survival time of NPC patients significantly (P < 0.05).
  
  
  CONCLUSIONS
  The Rad52 expression can be a useful prognostic and treatment factor for NPC patients.
authors.forename: Lili
authors.initials: L
authors.lastname: Wei
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Yang
authors.forename: Huixin
authors.initials: H
authors.lastname: Ming
authors.forename: Ping
authors.initials: P
authors.lastname: Li
mesh_terms: D000328:Adult; D002277:Carcinoma; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism*; D009367:Neoplasm Staging; D051721:Rad52 DNA Repair and Recombination Protein / Q000378:metabolism*; D015996:Survival Rate; D055815:Young Adult
chemical_list: C497194:RAD52 protein, human; D051721:Rad52 DNA Repair and Recombination Protein