title: Treatment of acute pulmonary embolism: update on newer pharmacologic and interventional strategies.
abstract: Acute pulmonary embolism (PE) is a common complication in hospitalized patients, spanning multiple patient populations and crossing various therapeutic disciplines. Current treatment paradigm in patients with massive PE mandates prompt risk stratification with aggressive therapeutic strategies. With the advent of endovascular technologies, various catheter-based thrombectomy and thrombolytic devices are available to treat patients with massive or submassive PE. In this paper, a variety of newer treatment strategies for PE are analyzed, with special emphasis on various interventional treatment strategies. Clinical evidence for utilizing endovascular treatment modalities, based on our institutional experience as well as a literature review, is provided.
authors.affiliation: Department of Heart and Great Vessels "Attilio Reale", Sapienza University, Viale del Policlinico 155, 00161 Rome, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Pelliccia
authors.affiliation: Department of Heart and Great Vessels "Attilio Reale", Sapienza University, Viale del Policlinico 155, 00161 Rome, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Schiariti
authors.affiliation: Respiratory Diseases Unit, "Sapienza" University, Rome, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Terzano
authors.affiliation: Department of Internal Medicine, Division of Cardiology, University of North Texas Health Science Center, Fort Worth, TX, USA.
authors.forename: Abdul M
authors.initials: AM
authors.lastname: Keylani
authors.affiliation: Department of Internal Medicine, Division of Cardiology, University of North Texas Health Science Center, Fort Worth, TX, USA.
authors.forename: Darrin C
authors.initials: DC
authors.lastname: D'Agostino
authors.affiliation: Anthea Hospital, GVM Care & Research, ES Health Science Foundation, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Speziale
authors.affiliation: Department of Heart and Great Vessels "Attilio Reale", Sapienza University, Viale del Policlinico 155, 00161 Rome, Italy.
authors.forename: Cesare
authors.initials: C
authors.lastname: Greco
authors.affiliation: Department of Heart and Great Vessels "Attilio Reale", Sapienza University, Viale del Policlinico 155, 00161 Rome, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Gaudio
mesh_terms: D000328:Adult; D000792:Angiography; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery*; D015912:Thrombolytic Therapy