title: [Features of the humoral immune response in patients with chronic hepatitis C, spontaneous clearance of hepatitis C virus and false-positive reactions of anti-HCV].
abstract: Among the patients residing in the territory of Ukraine false-positive reaction of anti-HCV was determined in 5.4% of anti-HCVpositive patients with low frequency of antibodies and low reactivity of sera to a structural viral protein or nonstructural viral proteins (by SIA or RIBA). Cases of spontaneous clearance of hepatitis C virus (HCV) were detected in 16.1% of anti-HCV positive patients and based on the detection of antibodies to the core-protein and one or several of nonstructural viral proteins on condition negativation of RNA-HCV twice with an interval of 6-12 months. Chronic hepatitis C with the presence of specific RNA-HCV in blood serum was confirmed in 83.9% of patients. The group of examinees with spontaneous clearance of HCV was characterized by low humoral immune response compared to chronic persistent infection.
authors.forename: N A
authors.initials: NA
authors.lastname: Zhandarova
mesh_terms: D000293:Adolescent; D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005189:False Positive Reactions; D016174:Hepacivirus / Q000276:immunology / Q000472:pathogenicity; D018937:Hepatitis C Antibodies / Q000276:immunology*; D019698:Hepatitis C, Chronic / Q000097:blood / Q000276:immunology* / Q000473:pathology; D006801:Humans; D056724:Immunity, Humoral; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D014455:Ukraine; D014758:Viral Core Proteins / Q000276:immunology; D017361:Viral Nonstructural Proteins / Q000276:immunology*; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases
chemical_list: D018937:Hepatitis C Antibodies; D014758:Viral Core Proteins; D017361:Viral Nonstructural Proteins; C084422:NS3 protein, hepatitis C virus; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases; C433031:hepatitis C protein F, Hepatitis C virus