title: 15-deoxy-Δ12,14-prostaglandin J2 reduces albumin-induced arthritis in temporomandibular joint of rats.
abstract: The aim of this study was to evaluate the peripheral effect of 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) in albumin-induced arthritis in temporomandibular joint (TMJ) of rats. Antigen-induced arthritis (AIA) was generated in rats with methylated bovine serum albumin (mBSA) diluted in complete Freund׳s adjuvant. Pretreatment with an intra-articular injection of 15d-PGJ2 (100 ng/TMJ) before mBSA intra-articular injection (10 µg/TMJ) (challenge) in immunized rats significantly reduced the albumin-induced arthritis inflammation. The results demonstrated that 15d-PGJ2 was able to inhibit plasma extravasation, leukocyte migration and the release of inflammatory cytokines IL-6, IL-12, IL-18 and the chemokine CINC-1 in the TMJ tissues. In addition, 15d-PGJ2 was able to increase the expression of the anti-adhesive molecule CD55 and the anti-inflammatory cytokine IL-10. Taken together, it is possible to suggest that 15d-PGJ2 inhibit leukocyte infiltration and subsequently inflammatory process, through a shift in the balance of the pro- and anti-adhesive properties. Thus, 15d-PGJ2 might be used as a potential anti-inflammatory drug to treat arthritis-induced inflammation of the temporomandibular joint.
authors.affiliation: Laboratory of Orofacial Pain, Department of Physiological Sciences, Piracicaba Dental School, University of Campinas, Brazil.
authors.forename: Mariana
authors.initials: M
authors.lastname: Silva Quinteiro
authors.affiliation: Laboratory of Immunology and Molecular Biology, São Leopoldo Mandic Institute and Research Center, Campinas, Brazil.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Henrique Napimoga
authors.affiliation: Laboratory of Orofacial Pain, Department of Physiological Sciences, Piracicaba Dental School, University of Campinas, Brazil.
authors.forename: Cristina
authors.initials: C
authors.lastname: Gomes Macedo
authors.affiliation: Laboratory of Orofacial Pain, Department of Physiological Sciences, Piracicaba Dental School, University of Campinas, Brazil.
authors.forename: Fabiana
authors.initials: F
authors.lastname: Furtado Freitas
authors.affiliation: Laboratory of Orofacial Pain, Department of Physiological Sciences, Piracicaba Dental School, University of Campinas, Brazil.
authors.forename: Henrique
authors.initials: H
authors.lastname: Balassini Abdalla
authors.affiliation: Laboratory of Orofacial Pain, Department of Physiological Sciences, Piracicaba Dental School, University of Campinas, Brazil.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Bonfante
authors.affiliation: Laboratory of Orofacial Pain, Department of Physiological Sciences, Piracicaba Dental School, University of Campinas, Brazil. Electronic address: juliana.napimoga@fop.unicamp.br.
authors.forename: Juliana
authors.initials: J
authors.lastname: Trindade Clemente-Napimoga
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000941:Antigens; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000276:immunology; D018958:CD55 Antigens / Q000276:immunology; D002465:Cell Movement / Q000187:drug effects; D016207:Cytokines / Q000276:immunology; D005620:Freund's Adjuvant; D007270:Injections, Intra-Articular; D018799:Intercellular Adhesion Molecule-1 / Q000276:immunology; D007962:Leukocytes / Q000187:drug effects / Q000502:physiology; D008297:Male; D015230:Prostaglandin D2 / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D017208:Rats, Wistar; D012710:Serum Albumin, Bovine; D013705:Temporomandibular Joint Disorders / Q000188:drug therapy* / Q000276:immunology
chemical_list: C477819:15-deoxyprostaglandin J2; D000893:Anti-Inflammatory Agents; D000941:Antigens; D018958:CD55 Antigens; D016207:Cytokines; D018799:Intercellular Adhesion Molecule-1; D012710:Serum Albumin, Bovine; D005620:Freund's Adjuvant; D015230:Prostaglandin D2
keywords: 15d-PGJ(2); Inflammation; Temporomandibular joint