title: Vitamin D receptor activation: cardiovascular and renal implications.
abstract: The effects of vitamin D receptor activation on cardiovascular diseases, especially hypertension and cardiac dysfunction, are areas of active investigation. This article reviews the current state of knowledge about vitamin D receptor activation with respect to blood pressure, heart, and vascular health, as well as to chronic kidney disease and end-stage renal disease. Potential biological mechanisms, the role of vitamin D-binding protein, and data from observational and randomized controlled trials on this topic are summarized.
authors.affiliation: Division of Nephrology, Massachusetts General Hospital , Boston, Massachusetts, USA.
authors.forename: Sagar U
authors.initials: SU
authors.lastname: Nigwekar
authors.affiliation: Division of Nephrology, Massachusetts General Hospital , Boston, Massachusetts, USA.
authors.forename: Ravi
authors.initials: R
authors.lastname: Thadhani
keywords: chronic kidney disease; end-stage renal disease; hypertension; left ventricular hypertrophy; vitamin D; vitamin D-binding protein