title: Expanded criteria donors.
abstract: The greatest challenge facing liver transplantation today is the shortage of donor livers. Demand far exceeds supply, and this deficit has driven expansion of what is considered an acceptable organ. The evolving standard has not come without costs, however, as each new frontier of expanded donor quality (i.e., advancing donor age, donation after cardiac death, and split liver) may have traded wait-list for post-transplant morbidity and mortality. This article delineates the nature and severity of risk associated with specific deceased donor liver characteristics and recommends strategies to maximally mitigate these risks.
authors.affiliation: Division of Abdominal Transplantation, Department of Surgery, University of California, 505 Parnassus Avenue, UCSF Box 0780, San Francisco, San Francisco, CA 94143, USA. Electronic address: Sandy.feng@ucsfmedctr.org.
authors.forename: Sandy
authors.initials: S
authors.lastname: Feng
authors.affiliation: Division of Gastroenterology/Hepatology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Lai
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D003643:Death; D046148:Donor Selection; D005234:Fatty Liver / Q000473:pathology; D006085:Graft Survival; D015658:HIV Infections / Q000635:transmission; D006525:Hepatitis, Viral, Human / Q000635:transmission; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects; D008875:Middle Aged; D009369:Neoplasms / Q000473:pathology; D011379:Prognosis; D012307:Risk Factors; D014019:Tissue Donors; D055815:Young Adult
keywords: Deceased donor; Donor age; Outcomes; Steatosis; Surgery