title: Serum anti-Müllerian hormone and insulin resistance in the main phenotypes of non-obese polycystic ovarian syndrome women in China.
abstract: OBJECTIVE
  Objective was to evaluate anti-Müllerian-hormone (AMH) and parameters for insulin resistance (IR) in the main phenotypes of polycystic ovarian syndrome (PCOS), and to investigate their correlation for the first time in non-obese Chinese women.
  
  
  METHODS
  Within this prospective study, 160 PCOS cases and 40 healthy women, matched by age and BMI, were included. In four groups (n = 40) according to the four phenotypes of PCOS by definition of the National Institute of Health (2012), AMH, ovarian volume and number of follicles 2-9 mm were assessed as well as insulin resistance indexes (Homeostatic Model Assessment) (HOMA-IR) and Quantitative Insulin Sensitivity Check Index (QUICKI).
  
  
  RESULTS
  AMH levels were higher in PCOS than in controls, with differences comparing the phenotypes, highest in the group with all three criteria for PCOS. However, for HOMA-IR and QUICKI and correlation to AMH no significant differences were found.
  
  
  CONCLUSIONS
  AMH is a useful parameter to assess in the different phenotypes the severity of PCOS, and to compare with healthy women, for the first time demonstrated in Chinese patients. In contrast, the parameters for IR and their relation to AMH did not show clear differences comparing the four phenotypes, and need further investigation.
authors.affiliation: Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University , Beijing , China and.
authors.forename: Xuanxuan
authors.initials: X
authors.lastname: Tian
authors.forename: Xiangyan
authors.initials: X
authors.lastname: Ruan
authors.forename: Alfred O
authors.initials: AO
authors.lastname: Mueck
authors.forename: Diethelm
authors.initials: D
authors.lastname: Wallwiener
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
authors.forename: Shunyu
authors.initials: S
authors.lastname: Liu
authors.forename: Dongmei
authors.initials: D
authors.lastname: Yin
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Lu
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.forename: Hongqin
authors.initials: H
authors.lastname: Wu
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015992:Body Mass Index; D002681:China; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology* / Q000528:radiation effects; D010641:Phenotype; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D054304:Anti-Mullerian Hormone
keywords: Anti-Müllerian hormone; insulin resistance; polycystic ovarian syndrome