title: LRRC19 expressed in the kidney induces TRAF2/6-mediated signals to prevent infection by uropathogenic bacteria.
abstract: The innate immune-dependent bactericidal effects are critical for preventing microbial colonization in the urinary system. However, the mechanisms involved in establishing innate immune responses in kidney are not completely understood. Here we describe the role of a novel member of the LRR (leucine-rich repeat) class of transmembrane proteins, LRRC19 (LRR-containing 19) in eliminating uropathogenic bacteria. LRRC19 is predominantly expressed in human and mouse kidney tubular epithelial cells and LRRC19-deficient mice are more susceptible to uropathogenic Escherichia coli (UPEC) infection than wild-type or TLR4 knockout mice. Recognition of UPEC by LRRC19 induces the production of cytokines, chemokines and antimicrobial substances through TRAF2- and TRAF6-mediated NF-κB and MAPK signalling pathways. Thus, LRRC19 may be a critical pathogen-recognition receptor in kidney mediating the elimination of UPEC infection.
authors.affiliation: 1] Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin, China [2].
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Su
authors.affiliation: 1] Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin, China [2].
authors.forename: Siping
authors.initials: S
authors.lastname: Min
authors.affiliation: 1] Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin, China [2].
authors.forename: Shuisong
authors.initials: S
authors.lastname: Cao
authors.affiliation: Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Yan
authors.affiliation: Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin, China.
authors.forename: Yining
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin, China.
authors.forename: Limin
authors.initials: L
authors.lastname: Chai
authors.affiliation: Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin, China.
authors.forename: Shiyue
authors.initials: S
authors.lastname: Mei
authors.affiliation: Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin, China.
authors.forename: Zhujun
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin, China.
authors.forename: Feifei
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
authors.affiliation: 1] Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin, China [2] Key Laboratory of Bioactive Materials Ministry of Education, Nankai University, Tianjin, China.
authors.forename: Yongzhe
authors.initials: Y
authors.lastname: Che
authors.affiliation: 1] Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin, China [2] Key Laboratory of Bioactive Materials Ministry of Education, Nankai University, Tianjin, China [3] State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, China.
authors.forename: Rongcun
authors.initials: R
authors.lastname: Yang
mesh_terms: D000818:Animals; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism* / Q000382:microbiology*; D005260:Female; D007668:Kidney / Q000166:cytology / Q000378:metabolism* / Q000382:microbiology*; D007684:Kidney Tubules / Q000166:cytology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism*; D047992:TNF Receptor-Associated Factor 2 / Q000235:genetics / Q000378:metabolism*; D048029:TNF Receptor-Associated Factor 6 / Q000235:genetics / Q000378:metabolism*; D056689:Uropathogenic Escherichia coli / Q000472:pathogenicity*
chemical_list: C544175:LRRC19 protein, mouse; D011956:Receptors, Cell Surface; D047992:TNF Receptor-Associated Factor 2; D048029:TNF Receptor-Associated Factor 6