title: A model of grid cell development through spatial exploration and spike time-dependent plasticity.
abstract: Grid cell responses develop gradually after eye opening, but little is known about the rules that govern this process. We present a biologically plausible model for the formation of a grid cell network. An asymmetric spike time-dependent plasticity rule acts upon an initially unstructured network of spiking neurons that receive inputs encoding animal velocity and location. Neurons develop an organized recurrent architecture based on the similarity of their inputs, interacting through inhibitory interneurons. The mature network can convert velocity inputs into estimates of animal location, showing that spatially periodic responses and the capacity of path integration can arise through synaptic plasticity, acting on inputs that display neither. The model provides numerous predictions about the necessity of spatial exploration for grid cell development, network topography, the maturation of velocity tuning and neural correlations, the abrupt transition to stable patterned responses, and possible mechanisms to set grid period across grid modules.
authors.affiliation: Center for Learning and Memory and Department of Neuroscience, The University of Texas at Austin, Austin, TX 78712, USA.
authors.forename: John
authors.initials: J
authors.lastname: Widloski
authors.affiliation: Center for Learning and Memory and Department of Neuroscience, The University of Texas at Austin, Austin, TX 78712, USA. Electronic address: ilafiete@mail.clm.utexas.edu.
authors.forename: Ila R
authors.initials: IR
authors.lastname: Fiete
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D005106:Exploratory Behavior / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology; D007395:Interneurons / Q000502:physiology; D008959:Models, Neurological; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D013037:Spatial Behavior / Q000502:physiology