title: Integrin and cadherin signaling in bone: role and potential therapeutic targets.
abstract: Cell-cell and cell-matrix interactions mediated by cell adhesion molecules are important mechanisms controlling cell fate and function. Here, we review recent advances in the implication of the cell adhesion molecules integrins and cadherins in the control of osteoblastogenesis and bone formation. We discuss emerging evidence indicating that signaling pathways mediated by integrins and cadherins and their crosstalk with the Wnt/β-catenin signaling pathway regulate osteogenic differentiation and mechanotransduction. We also offer a comprehensive view of the mechanisms by which some integrins and cadherins control the differentiation of cells of the osteoblast lineage in bone marrow niches. Understanding how specific integrins or cadherins may promote osteogenic cell differentiation, bone formation, and repair may lead to novel therapeutic strategies.
authors.affiliation: UMR-1132 INSERM and University Paris Diderot, Sorbonne Paris Cité, Paris, 75475 cedex 10, France. Electronic address: pierre.marie@inserm.fr.
authors.forename: Pierre J
authors.initials: PJ
authors.lastname: Marie
authors.affiliation: UMR-1132 INSERM and University Paris Diderot, Sorbonne Paris Cité, Paris, 75475 cedex 10, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Haÿ
authors.affiliation: UMR-1132 INSERM and University Paris Diderot, Sorbonne Paris Cité, Paris, 75475 cedex 10, France.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Saidak
mesh_terms: D000818:Animals; D001862:Bone Resorption / Q000628:therapy*; D001842:Bone and Bones / Q000378:metabolism*; D015820:Cadherins / Q000378:metabolism* / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D006801:Humans; D016023:Integrins / Q000378:metabolism* / Q000502:physiology; D058990:Molecular Targeted Therapy / Q000379:methods; D010006:Osteoblasts / Q000502:physiology; D010012:Osteogenesis / Q000502:physiology; D015398:Signal Transduction; D060449:Wnt Signaling Pathway
chemical_list: D015820:Cadherins; D016023:Integrins
keywords: Wnt signaling; bone formation; bone repair; cadherins; integrins; niches