title: Histopathological screening for prostate carcinoma: is a benign biopsy a negative biopsy?
abstract: In case of clinical suspicion of a prostate malignancy, a prostate biopsy is the most widely used approach to confirm prostate cancer. Unfortunately, exclusion of prostate cancer is not feasible by means of biopsy and also the negative rate remains consistently high. Here, we review the information the surgical pathologist can still gain from a prostate biopsy in absence of overt carcinoma.
authors.affiliation: Institute of Pathology, University Hospital of Bonn, Bonn, Germany.
authors.forename: Verena
authors.initials: V
authors.lastname: Sailer
authors.forename: Glen
authors.initials: G
authors.lastname: Kristiansen
mesh_terms: D001706:Biopsy; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology; D051517:Digital Rectal Examination; D055088:Early Detection of Cancer; D051549:Glutathione S-Transferase pi / Q000378:metabolism; D006801:Humans; D008297:Male; D011467:Prostate / Q000473:pathology* / Q000601:surgery*; D017430:Prostate-Specific Antigen / Q000097:blood; D019048:Prostatic Intraepithelial Neoplasia / Q000473:pathology; D011471:Prostatic Neoplasms / Q000473:pathology*
chemical_list: C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi; D017430:Prostate-Specific Antigen
keywords: ASAP; PIA; PIN; Prostate; biopsy