title: Reversible supramolecular assembly at specific DNA sites: nickel-promoted bivalent DNA binding with designed peptide and bipyridyl-bis(benzamidine) components.
abstract: At specific DNA sites, nickel(II) salts promote the assembly of designed components, namely a bis(histidine)-modified peptide that is derived from a bZIP transcription factor and a bis(benzamidine) unit that is equipped with a bipyridine. This programmed supramolecular system with emergent properties reproduces some key characteristics of naturally occurring DNA-binding proteins, such as bivalence, selectivity, responsiveness to external agents, and reversibility.
authors.affiliation: Departamento de Química Orgánica and Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela (Spain).
authors.forename: Mateo I
authors.initials: MI
authors.lastname: Sánchez
authors.forename: Jesús
authors.initials: J
authors.lastname: Mosquera
authors.forename: M Eugenio
authors.initials: ME
authors.lastname: Vázquez
authors.forename: José L
authors.initials: JL
authors.lastname: Mascareñas
mesh_terms: D001550:Benzamidines / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D004268:DNA-Binding Proteins; D009532:Nickel / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D014157:Transcription Factors
chemical_list: D001550:Benzamidines; D004268:DNA-Binding Proteins; D010455:Peptides; D014157:Transcription Factors; D009532:Nickel; D004247:DNA; C032157:benzamidine
keywords: DNA recognition; minor-groove binders; peptides; self-assembly; supramolecular chemistry