title: Behavioral and electrophysiological responses of Aedes albopictus to certain acids and alcohols present in human skin emanations.
abstract: Human skin emanations attract hungry female mosquitoes toward their host for blood feeding. In this study, we report the flight orientation and electroantennogram response of Aedes albopictus females to certain unsaturated acids and alcohols found in human skin. In the Y-tube olfactometer, odors of lactic acid and 2-methyl-3-pentanol attracted 54-65% of Ae. albopictus females at all doses in a dose-dependent manner. However, at the highest dose (10(-2) g), the acids repelled 40-45% females. Attractancy (ca. 62-68%) at lower doses and repellency (ca. 30-45%) at higher doses were recorded for 3-methyl-3-pentanol and 1-octen-3-ol, while 5-hexen-1-ol, cis-2-hexen-1-ol, and trans 2-hexen-1-ol odor repelled ca. 55-65% of Ae. albopictus females at all doses. Antenna of female Ae. albopictus exhibited a dose-dependent EAG response up to 10(-3) g of L-lactic acid, trans-2-methyl-2-pentenoic acid, 2-octenoic acid, trans-2-hexen-1-ol and 1-octen-3-ol stimulations; however, the highest dose (10(-2) g) caused a little decline in the EAG response. EAG response of 9-10-fold was elicited by lactic acid, 2-octenoic acid, trans-2-hexenoic acid, and 3-methyl-3-pentanol, while cis-2-hexen-1-ol and trans-2-methyl pentenoic acid elicited 1-5-fold responses compared to solvent control. A blend of attractive compounds could be utilized in odor-baited trap for surveillance and repellent molecules with suitable formulation could be used to reduce the biting menace of mosquitoes.
authors.affiliation: Defence Research and Development Establishment, Jhansi Road, Gwalior, 474 002, Madhya Pradesh, India.
authors.forename: Lopamudra
authors.initials: L
authors.lastname: Guha
authors.forename: T
authors.initials: T
authors.lastname: Seenivasagan
authors.forename: S Thanvir
authors.initials: ST
authors.lastname: Iqbal
authors.forename: O P
authors.initials: OP
authors.lastname: Agrawal
authors.forename: B D
authors.initials: BD
authors.lastname: Parashar
mesh_terms: D000330:Aedes / Q000187:drug effects / Q000502:physiology*; D000438:Alcohols / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D005260:Female; D006801:Humans; D007302:Insect Repellents / Q000494:pharmacology*; D019344:Lactic Acid / Q000494:pharmacology; D009812:Odorants; D064367:Olfactometry; D010675:Pheromones / Q000494:pharmacology*; D012867:Skin / Q000737:chemistry; D012903:Smell
chemical_list: D000438:Alcohols; D007302:Insect Repellents; D010675:Pheromones; C010411:insect attractants; D019344:Lactic Acid