title: Exhaled nitric oxide and nasal tryptase are associated with wheeze, rhinitis and nasal allergy in primary school children.
abstract: Rhinitis and asthma are the most common respiratory diseases in children. We assessed whether airway inflammation markers were associated with nasal allergies and self-reported symptoms of wheeze and rhinitis in 130 children 6-12 year old in an epidemiological context. Independent of sex and age, the fraction of exhaled nitric oxide (FeNO) and nasal mast cell (MC) activation (tryptase ≥ 5 ng/mL) were positively associated with wheeze, rhinitis and with nasal allergy. Nasal eosinophil cationic protein (ECP) and exhaled breath condensate (EBC) markers (pH, 8-isoprostane, interleukin-1β) were not associated with symptoms or with nasal allergy. In conclusion, FeNO and nasal tryptase reflect allergic inflammation in the respiratory system.
authors.affiliation: Environmental Risk and Health Unit, VITO (Flemish Institute for Technological Research) , Boeretang , Belgium .
authors.forename: Sofie
authors.initials: S
authors.lastname: De Prins
authors.forename: Francesco
authors.initials: F
authors.lastname: Marcucci
authors.forename: Laura
authors.initials: L
authors.lastname: Sensi
authors.forename: Els
authors.initials: E
authors.lastname: Van de Mieroop
authors.forename: Vera
authors.initials: V
authors.lastname: Nelen
authors.forename: Tim S
authors.initials: TS
authors.lastname: Nawrot
authors.forename: Greet
authors.initials: G
authors.lastname: Schoeters
authors.forename: Gudrun
authors.initials: G
authors.lastname: Koppen
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D002648:Child; D045853:Exhalation; D005260:Female; D006801:Humans; D008297:Male; D009297:Nasal Mucosa / Q000201:enzymology*; D009569:Nitric Oxide / Q000378:metabolism*; D012135:Respiratory Sounds; D065631:Rhinitis, Allergic / Q000378:metabolism*; D053802:Tryptases / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D009569:Nitric Oxide; D053802:Tryptases
keywords: Eosinophil cationic protein; Rhinostick; exhaled breath condensate; mast cells