title: Cor a 14: missing link in the molecular diagnosis of hazelnut allergy?
abstract: BACKGROUND
  Hazelnut allergy shows distinct clinical patterns that can be predicted through component-resolved diagnosis. However, identification of sensitization profiles remains incomplete.
  
  
  METHODS
  Sera of 75 patients allergic to hazelnuts, 14 infants with atopic dermatitis (AD) sensitized to hazelnuts, 15 hazelnut-tolerant individuals with specific IgE (sIgE) to hazelnuts and 15 healthy control individuals were tested for sIgE reactivity to rCor a 1.04, rCor a 8, nCor a 9, nCor a 11, rCor a 14, rBet v 1, rBet v 2 and cross-reactive carbohydrate determinants (CCDs).
  
  
  RESULTS
  Sensitization to Cor a 14 was observed in 18 out of 20 preschool children, 8 out of 10 school-aged children and 2 out of 7 adults with generalized reactions and in 3 out of 14 infants with AD. Only 2 out of 38 patients with an oral allergy syndrome (OAS) were sensitized to Cor a 14. No sensitization to Cor a 14 was observed in the group of hazelnut-tolerant and healthy control individuals. Sensitization to Cor a 1.04 was seen in 36 out of 38 OAS patients and in 14 out of 37 patients with generalized reactions. However, only 3 patients with generalized reactions were monosensitized to Cor a 1.04. Sensitization to Cor a 9 was observed in 26 out of 37 patients with generalized reactions and in 4 out of 14 infants with AD. Sensitization to Cor a 11, Cor a 8, rBet v 2 and CCDs was rare.
  
  
  CONCLUSIONS
  Sensitization to Cor a 14 can have early onset and shows age-related variations. Together with Cor a 9, Cor a 14 enables us to correctly identify almost 90% of children with generalized reactions to hazelnut.
authors.affiliation: Department of Immunology-Allergology-Rheumatology, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
authors.forename: Margaretha A
authors.initials: MA
authors.lastname: Faber
authors.forename: Maaike
authors.initials: M
authors.lastname: De Graag
authors.forename: Catherina
authors.initials: C
authors.lastname: Van Der Heijden
authors.forename: Vito
authors.initials: V
authors.lastname: Sabato
authors.forename: Margo M
authors.initials: MM
authors.lastname: Hagendorens
authors.forename: Chris H
authors.initials: CH
authors.lastname: Bridts
authors.forename: Luc S
authors.initials: LS
authors.lastname: De Clerck
authors.forename: Didier G
authors.initials: DG
authors.lastname: Ebo
mesh_terms: D055516:2S Albumins, Plant / Q000276:immunology; D000293:Adolescent; D000328:Adult; D000485:Allergens / Q000276:immunology*; D052179:Antigens, Plant / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D031211:Corylus / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D007223:Infant; D007231:Infant, Newborn; D025202:Molecular Diagnostic Techniques; D021184:Nut Hypersensitivity / Q000276:immunology*; D010940:Plant Proteins / Q000276:immunology; D055815:Young Adult
chemical_list: D055516:2S Albumins, Plant; D000485:Allergens; D052179:Antigens, Plant; C000594310:Cor a 14 allergen, hazelnut; C466060:Cor a 9 protein, hazelnut; C061277:Cor a I protein, hazel; D010940:Plant Proteins; D007073:Immunoglobulin E