title: The kidney biopsy in lupus nephritis: is it still relevant?
abstract: The kidney biopsy is the standard of care for diagnosis of lupus nephritis and remains necessary to ensure accurate diagnosis and guide treatment. Repeat biopsy should be considered when therapy modifications are necessary, as in cases with incomplete or no response, or when stopping therapy for those in remission. There are several promising biomarkers of kidney disorders; however, these markers need to be validated in a prospective clinical trial before being applied clinically. Molecular analysis may provide the information presently lacking from current evaluation of kidney disorders and may better inform on prognosis and treatment considerations.
authors.affiliation: Nephrology Division, Department of Internal Medicine, Ohio State University Wexner Medical Center, 395 West 12th Avenue, Columbus, OH 43210, USA. Electronic address: rovin.1@osu.edu.
authors.forename: Brad H
authors.initials: BH
authors.lastname: Rovin
authors.affiliation: Nephrology Division, Department of Internal Medicine, Ohio State University Wexner Medical Center, 395 West 12th Avenue, Columbus, OH 43210, USA.
authors.forename: Samir V
authors.initials: SV
authors.lastname: Parikh
authors.affiliation: Nephrology Division, Department of Internal Medicine, Ohio State University Wexner Medical Center, 395 West 12th Avenue, Columbus, OH 43210, USA.
authors.forename: Anthony
authors.initials: A
authors.lastname: Alvarado
mesh_terms: D000465:Algorithms; D015415:Biomarkers / Q000032:analysis; D001706:Biopsy / Q000379:methods*; D057186:Comparative Effectiveness Research; D019468:Disease Management; D016903:Drug Monitoring / Q000379:methods / Q000592:standards; D006801:Humans; D007668:Kidney / Q000473:pathology*; D008181:Lupus Nephritis / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism; D011379:Prognosis; D015203:Reproducibility of Results; D059039:Standard of Care
chemical_list: D015415:Biomarkers
keywords: Kidney biopsy; Lupus nephritis; Systemic lupus erythematosus