title: [Expression of neuronal marker protein gene product 9.5 and its clinicopathologic significance in breast cancer].
abstract: OBJECTIVE
  To detect the expression of pan-neuronal marker protein gene product (PGP)9.5 and its clinicopathologic significance in breast cancer.
  
  
  METHODS
  The expression of PGP9.5 was examined by immunohistochemistry EnVision method in 196 cases during 2007 to 2011, including 20 normal tissues, 14 cases of fibroadenoma, 18 cases of ductal carcinoma in situ (DCIS) and 144 cases of invasive ductal carcinoma (IDC) of the breast. The relationship between PGP9.5 expression and clinicopathologic characteristics of IDC was assessed.
  
  
  RESULTS
  PGP9.5 expression was localized in the stroma of all normal breast tissues, but there was no expression observed in all fibroadenomas and DCIS. Overall, the expression rate of PGP9.5 in IDC was 61.8% (89/144). PGP9.5 expression increased from grade 1 tumors (29.4%, 10/34) to grade 2-3 tumors (71.8%, 79/110; P = 0.000). In addition, patients with less than 3 years disease-free survival tended to show higher PGP9.5 expression (64.8%, 35/54), compared to patients with equal to and/or more than 3 years disease-free survival (46.7%, 42/90; P = 0.035). However, there was no correlation between PGP9.5 expression and tumor size, tumor stage, lymph metastasis, hormone receptor expression.
  
  
  CONCLUSIONS
  PGP9.5 expression is correlated with tumor grade and prognosis in IDC of the breast.
authors.affiliation: Department of Pathology, Shanghai Third People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 201999, China.
authors.forename: Liwei
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Pathology, Shanghai Third People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 201999, China.
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Department of Pathology, Shanghai Third People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 201999, China.
authors.forename: Xizi
authors.initials: X
authors.lastname: Liang
authors.affiliation: Department of Pathology, Shanghai Third People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 201999, China.
authors.forename: Guangye
authors.initials: G
authors.lastname: Du
authors.affiliation: Department of Pathology, Shanghai Third People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 201999, China.
authors.forename: Lingjuan
authors.initials: L
authors.lastname: Lu
authors.affiliation: Department of Pathology, Shanghai Third People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 201999, China.
authors.forename: Junbo
authors.initials: J
authors.lastname: Dong
authors.affiliation: Department of Pathology, Shanghai Third People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 201999, China. E-mail: hxhan2004@hotmail.com.
authors.forename: Hongxiu
authors.initials: H
authors.lastname: Han
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism* / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000378:metabolism / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D018226:Fibroadenoma / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D060787:Neoplasm Grading; D043222:Ubiquitin Thiolesterase / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; C482860:UCHL1 protein, human; D043222:Ubiquitin Thiolesterase