title: [Hormone therapy alone for pre-cancerous conditions and early endometrial cancer: pros and cons].
abstract: The results of conservative treatment of 121 patients with endometrial atypical hyperplasia (EAH) and early endometrial cancer (EC) with preservation of fertility are presented. In EAH (n = 56) for 6 months the intrauterine spiral Mirena was used. The effectiveness was 91%, the recurrence rate 16%, pregnancies occurred in 16% of patients. In EC (n = 65) hormone therapy was conducted for 6 months using the intrauterine spiral Mirena and zoladex. The effectiveness was 79%, recurrence rate 22%, pregnancies occurred in 24% of patients. Based on our data and on the results of other studies, the benefits and risks of hormone therapy alone for EAH and EC are discussed in women of reproductive age.
authors.forename: O V
authors.initials: OV
authors.lastname: Novikova
authors.forename: Iu Iu
authors.initials: IuIu
authors.lastname: Andreeva
authors.forename: E G
authors.initials: EG
authors.lastname: Novikova
authors.forename: A N
authors.initials: AN
authors.lastname: Vostrov
authors.forename: S M
authors.initials: SM
authors.lastname: Pronin
authors.forename: N A
authors.initials: NA
authors.lastname: Rubtsova
authors.forename: N V
authors.initials: NV
authors.lastname: Danilova
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Lozovaia
authors.forename: D V
authors.initials: DV
authors.lastname: Podtetenev
mesh_terms: D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004714:Endometrial Hyperplasia / Q000188:drug therapy* / Q000473:pathology; D016889:Endometrial Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D017273:Goserelin / Q000008:administration & dosage; D006801:Humans; D016912:Levonorgestrel / Q000008:administration & dosage; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000517:prevention & control; D011230:Precancerous Conditions / Q000188:drug therapy* / Q000473:pathology; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy* / Q000473:pathology; D018873:Pregnancy Rate; D016896:Treatment Outcome
chemical_list: D018931:Antineoplastic Agents, Hormonal; D017273:Goserelin; D016912:Levonorgestrel