title: Preclinical studies of SPECT and PET tracers for NET.
abstract: Radiolabeled somatostatin analogues are routinely used for the detection of neuroendocrine tumors (NETs), exploiting the expression of somatostatin-receptor subtypes on the cell membrane. Because of the heterogeneity of the origin of these tumors, the performance of radiolabeled somatostatin analogues in certain types of NETs is limited due to the low incidence or low levels of receptor expression. In this review, the most recent developments and in vitro and in vivo characterization of these radiolabeled peptide analogues are discussed.
authors.affiliation: Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address: m.brom@nucmed.umcn.nl.
authors.forename: Maarten
authors.initials: M
authors.lastname: Brom
authors.affiliation: Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
authors.forename: Otto
authors.initials: O
authors.lastname: Boerman
authors.affiliation: Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
authors.forename: Martin
authors.initials: M
authors.lastname: Gotthardt
authors.affiliation: Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
authors.forename: Wim J G
authors.initials: WJ
authors.lastname: Oyen
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D000067757:Glucagon-Like Peptide-1 Receptor; D006801:Humans; D007340:Insulinoma / Q000000981:diagnostic imaging; D051379:Mice; D018358:Neuroendocrine Tumors / Q000000981:diagnostic imaging*; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging; D049268:Positron-Emission Tomography / Q000379:methods*; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D018004:Receptors, Bombesin / Q000528:radiation effects; D011949:Receptors, Cholecystokinin / Q000528:radiation effects; D018027:Receptors, Glucagon / Q000528:radiation effects; D013004:Somatostatin / Q000031:analogs & derivatives; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: C000593833:GLP1R protein, human; C000593834:Glp1r protein, mouse; D000067757:Glucagon-Like Peptide-1 Receptor; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D018004:Receptors, Bombesin; D011949:Receptors, Cholecystokinin; D018027:Receptors, Glucagon; D013004:Somatostatin
keywords: Animal models; Bombesin; Exendin; Gastrin; Positron Emission Tomography; Preclinical; Single Photon Emission Computed Tomography