title: The ICAM-1 K469E polymorphism is associated with the risk of coronary artery disease: a meta-analysis.
abstract: BACKGROUND
  The intercellular adhesion molecule-1 (ICAM-1) K469E polymorphism has been indicated to be correlated with coronary artery disease (CAD) susceptibility, but the results of studies are still debatable. Thus, a meta-analysis was carried out.
  
  
  METHODS
  Databases including PubMed, Embase, Web of Science, and CNKI were searched. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated.
  
  
  RESULTS
  Eighteen studies with 3546 cases and 3852 controls were included in this meta-analysis. The association between the ICAM-1 K469E polymorphism and the risk of CAD was significant (OR=1.77; 95% CI, 1.52-2.05; P<0.01; I=27%). This result remained statistically significant when the adjusted ORs were combined (OR=1.95; 95% CI, 1.78-2.14; P<0.01; I=0%). When stratified by ethnicity, a significantly increased risk was observed in Whites (OR=1.75; 95% CI, 1.37-2.23; P<0.01; I=58%) and in Asians (OR=1.80; 95% CI, 1.45-2.24; P<0.01; I=0%). A significantly increased risk of myocardial infarction was observed (OR=2.24; 95% CI, 1.72-2.92; P<0.01; I=38%).
  
  
  CONCLUSIONS
  In conclusion, this meta-analysis suggested that the ICAM-1 K469E polymorphism was a risk factor for CAD.
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China.
authors.forename: Daolin
authors.initials: D
authors.lastname: Li
authors.forename: Chunsheng
authors.initials: C
authors.lastname: Qu
authors.forename: Pingshuan
authors.initials: P
authors.lastname: Dong
mesh_terms: D044466:Asian People / Q000235:genetics; D016009:Chi-Square Distribution; D003327:Coronary Disease / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D009203:Myocardial Infarction / Q000208:ethnology / Q000235:genetics; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: C573420:ICAM1 protein, human; D018799:Intercellular Adhesion Molecule-1