title: ICG-liver test versus new biomarkers as prognostic markers for prolonged length of stay in critically ill patients - a prospective study of accuracy for prediction of length of stay in the ICU.
abstract: BACKGROUND
  Prognostic abilities of medical parameters, which are scoring systems, measurements and biomarkers, are important for stratifying critically ill patients. Indocyanine green plasma disappearance (ICG-PDR) is an established clinical tool for the assessment of liver perfusion and function. Copeptin, MR-proANP and pro-ADM are biomarkers whose prognostic value is still unclear. The goal of this prospective study was to evaluate ICG-PDR, copeptin, MR-proANP and pro-ADM to predict prolonged length of stay (pLOS) in the ICU.
  
  
  METHODS
  This study was conducted as a prospective single center study including 110 consecutively admitted ICU patients. Primary endpoint was prolonged length of stay (pLOS) in the ICU, defined as more than three days of stay there.
  
  
  RESULTS
  ROC analysis showed an AUC of 0.73 for ICG-PDR, 0.70 for SAPS II, 0.65 for MR-proANP, 0.64 for pro-ADM and 0.54 for copeptin for pLOS in the ICU.
  
  
  CONCLUSIONS
  The prediction of pLOS in the ICU might be better by means of ICG-PDR than with the new biomarkers copeptin, MR-proANP or pro-ADM. Nevertheless, there is more need for research to evaluate whether ICG-PDR is an overall prognostic marker for pLOS.
  
  
  BACKGROUND
  (ClinicalTrials.gov number, NCT01126554).
authors.affiliation: Surgical Intensive Care Medicine, University Hospital of Zurich, Raemistrasse 100, Zurich, CH-8091, Switzerland.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Zoller
authors.affiliation: Institute of Clinical Chemistry, University and University Hospital Zurich, Zurich, Switzerland.
authors.forename: Katharina
authors.initials: K
authors.lastname: Spanaus
authors.affiliation: Surgical Intensive Care Medicine, University Hospital of Zurich, Raemistrasse 100, Zurich, CH-8091, Switzerland.
authors.forename: Rahel
authors.initials: R
authors.lastname: Gerster
authors.affiliation: Surgical Intensive Care Medicine, University Hospital of Zurich, Raemistrasse 100, Zurich, CH-8091, Switzerland.
authors.forename: Mario
authors.initials: M
authors.lastname: Fasshauer
authors.affiliation: Surgical Intensive Care Medicine, University Hospital of Zurich, Raemistrasse 100, Zurich, CH-8091, Switzerland.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Stehberger
authors.affiliation: Surgical Intensive Care Medicine, University Hospital of Zurich, Raemistrasse 100, Zurich, CH-8091, Switzerland.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Klinzing
authors.affiliation: Institute of Clinical Chemistry, University and University Hospital Zurich, Zurich, Switzerland.
authors.forename: Athanasios
authors.initials: A
authors.lastname: Vergopoulos
authors.affiliation: Institute of Clinical Chemistry, University and University Hospital Zurich, Zurich, Switzerland.
authors.forename: Arnold
authors.initials: A
authors.lastname: von Eckardstein
authors.affiliation: Surgical Intensive Care Medicine, University Hospital of Zurich, Raemistrasse 100, Zurich, CH-8091, Switzerland ; Swiss Paraplegic Center, Nottwil, Switzerland.
authors.forename: Markus
authors.initials: M
authors.lastname: Béchir
keywords: Copeptin; ICG-Liver test; ICG-PDR; Length of stay in the ICU; MR-proANP; pLOS; pro-ADM