title: Association of CD98, integrin β1, integrin β3 and Fak with the progression and liver metastases of colorectal cancer.
abstract: CD98-mediated β1 and β3 integrins activation can induce Fak phosphorylation which eventually promotes cell survival, proliferation, and migration. We evaluated the expression of CD98, integrin β1, integrin β3 and Fak in 45 cases of matched colorectal cancer (CRC) and liver metastases as well as 35 cases of CRC without liver metastases. There was a gradual increase of the expression of CD98, integrin β1, integrin β3 and Fak as tumor progressed from normal colon to carcinoma to budding tumor cells at the invasive front and to liver metastases. The expression of CD98 and integrin β1 in CRC with liver metastases was significantly higher than that in CRC without liver metastases. Furthermore, for those liver metastases with desmoplastic growth pattern, expression of CD98, integrin β1, integrin β3 and Fak at the metastases center was as strong as that at the metastases periphery. For those liver metastases with pushing or replacement growth patterns, more intense expression of these markers was found at the metastases center than the periphery. Overexpression of CD98, integrin β1, integrin β3 and Fak is associated with the progression and liver metastases of CRC. Overexpression of these markers in liver metastases requires direct contact between tumor cells and the stroma.
authors.affiliation: Department of Pharmacology, Key Laboratory of Chemical Biology, School of Pharmaceutical Sciences, Shandong University, Jinan, China.
authors.forename: Cuicui
authors.initials: C
authors.lastname: Sun
authors.affiliation: Department of Pathology, McGill University, Montreal, Quebec, Canada.
authors.forename: Ramin
authors.initials: R
authors.lastname: Zargham
authors.affiliation: Department of Pathology, McGill University, Montreal, Quebec, Canada.
authors.forename: Qin
authors.initials: Q
authors.lastname: Shao
authors.affiliation: Department of Pathology, University of Calgary, Calgary, Alberta, Canada.
authors.forename: Xianyong
authors.initials: X
authors.lastname: Gui
authors.affiliation: Department of Pathology, McGill University, Montreal, Quebec, Canada.
authors.forename: Victoria
authors.initials: V
authors.lastname: Marcus
authors.affiliation: Department of Surgery, McGill University, Montreal, Quebec, Canada.
authors.forename: Anthoula
authors.initials: A
authors.lastname: Lazaris
authors.affiliation: Department of Surgery, McGill University, Montreal, Quebec, Canada.
authors.forename: Ayat
authors.initials: A
authors.lastname: Salman
authors.affiliation: Department of Surgery, McGill University, Montreal, Quebec, Canada.
authors.forename: Peter
authors.initials: P
authors.lastname: Metrakos
authors.affiliation: Department of Pathology, Beijing You An Hospital, Capital Medical University, Beijing, China. Electronic address: qxj@sdu.edu.cn.
authors.forename: Xianjun
authors.initials: X
authors.lastname: Qu
authors.affiliation: Department of Pathology, McGill University, Montreal, Quebec, Canada; Department of Pathology, Beijing You An Hospital, Capital Medical University, Beijing, China. Electronic address: zu-hua.gao@mcgill.ca.
authors.forename: Zuhua
authors.initials: Z
authors.lastname: Gao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000502:physiology*; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D051417:Focal Adhesion Kinase 1 / Q000378:metabolism*; D027261:Fusion Regulatory Protein-1 / Q000378:metabolism*; D006801:Humans; D019012:Integrin beta1 / Q000378:metabolism*; D039661:Integrin beta3 / Q000378:metabolism*; D008113:Liver Neoplasms / Q000378:metabolism* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D015398:Signal Transduction / Q000502:physiology
chemical_list: D027261:Fusion Regulatory Protein-1; D019012:Integrin beta1; D039661:Integrin beta3; D051417:Focal Adhesion Kinase 1; C496050:PTK2 protein, human
keywords: CD98; Colorectal cancer; Fak; Integrin; Liver metastasis