title: The association of oxidative stress and pro-inflammatory cytokines in diabetic patients with hyperglycemic crisis.
abstract: OBJECTIVE
  To investigate the relationship between oxidative stress and serum levels of pro-inflammatory cytokines in diabetic patients with hyperglycemic crisis.
  
  
  METHODS
  Seventy-three patients presenting to hospital with diabetic ketoacidosis or non-ketotic hyperglycemia were studied. Superoxide dismutase (SOD) activity, malondialdehyde (MDA) content, total antioxidant capacity (TAC), 8-iso-prostaglandin F2α (8-iso-prostaglandinF2α, 8-iso-PGF2α), tumor necrosis factor receptor-I (TNF-RI), interleukin -1β (IL-1β), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels were measured in all patients. The patients were then given an intravenous infusion of insulin 0.1U • kg-1 • h-1, as well as fluids, symptomatic therapy and parenteral and intravenous nutrition.
  Patients with hyperglycemic crises have significantly increased oxidative stress and dysregulated serum pro-inflammatory cytokines that can be effectively treated by intensive insulin therapy.
authors.affiliation: Department of Emergency, Zhongshan Hospital Xiamen University, Xiamen 361004, Fujian, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Endocrinology, Zhongshan Hospital Xiamen University, Xiamen 361004, Fujian, China.
authors.forename: Minglian
authors.initials: M
authors.lastname: Huang
authors.affiliation: Department of Endocrinology, Zhongshan Hospital Xiamen University, Xiamen 361004, Fujian, China. Electronic address: sxpsxzlg@hotmail.com.
authors.forename: Xingping
authors.initials: X
authors.lastname: Shen
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure; D016207:Cytokines / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D016883:Diabetic Ketoacidosis / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D018836:Inflammation Mediators / Q000097:blood*; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D007328:Insulin
keywords: Hyperglycemic crises; Oxidative stress; Pro-inflammatory cytokines