title: Long-term outcomes of boston type 1 keratoprosthesis implantation: a retrospective multicenter cohort.
abstract: OBJECTIVE
  To study the long-term outcomes of Boston type 1 keratoprosthesis (KPro) surgery.
  
  
  METHODS
  Retrospective, multicenter case series.
  
  
  METHODS
  A total of 158 eyes of 150 patients underwent KPro implantation at 5 participating tertiary centers in the United States between January 2003 and December 2006. Of those, 139 eyes of 133 patients were included in the analyses.
  
  
  METHODS
  The medical records of consecutive adult patients who received KPro surgery were reviewed. All patients with at least 1 postoperative visit were retained in the outcomes analyses. In eyes in which a repeat KPro procedure was performed, only the outcomes of the initial surgery were analyzed.
  
  
  METHODS
  Visual acuity (VA) outcomes, postoperative complications, and device retention.
  
  
  RESULTS
  The mean follow-up was 46.7 ± 26 months with all but 4 eyes having at least 6 months of follow-up. Preoperatively, only 10.8% of the eyes had VA of ≥ 20/200. Postoperatively, the VA in 70% of eyes improved to ≥ 20/200. The probability of maintaining VA of ≥ 20/200 at 7 years was 50%. The device retention rate was estimated at 67% at 7 years. The 7-year cumulative incidence of complications was 49.7% for retroprosthetic membrane formation, 21.6% for glaucoma surgery, 18.6% for retinal detachment, and 15.5% for endophthalmitis.
  
  
  CONCLUSIONS
  Although the risk for complications with longer follow-up seemed to increase, this large multicenter cohort demonstrates favorable outcomes with KPro, with a large number of patients achieving and retaining useful vision over a 7-year period.
authors.affiliation: The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Divya
authors.initials: D
authors.lastname: Srikumaran
authors.affiliation: The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Munoz
authors.affiliation: The Jules Stein Eye Institute, Los Angeles, California.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Aldave
authors.affiliation: Flaum Eye Institute, Rochester, New York.
authors.forename: James V
authors.initials: JV
authors.lastname: Aquavella
authors.affiliation: Wills Eye Institute, Philadelphia, Pennsylvania.
authors.forename: Sadeer B
authors.initials: SB
authors.lastname: Hannush
authors.affiliation: Albany Medical Center Department of Ophthalmology, Albany, New York.
authors.forename: Robert
authors.initials: R
authors.lastname: Schultze
authors.affiliation: University of Arizona Department of Ophthalmology, Tucson, Arizona.
authors.forename: Michael
authors.initials: M
authors.lastname: Belin
authors.affiliation: The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address: esakpek@jhmi.edu.
authors.forename: Esen Karamursel
authors.initials: EK
authors.lastname: Akpek
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D021522:Bioartificial Organs; D003315:Cornea; D003316:Corneal Diseases / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D019736:Prostheses and Implants; D012189:Retrospective Studies; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology*