title: Biodegradable ethylene-bis(propyl)disulfide-based periodic mesoporous organosilica nanorods and nanospheres for efficient in-vitro drug delivery.
abstract: Periodic mesoporous organosilica nanorods and nanospheres are synthesized from 1,4-bis(triethoxysilyl)ethylene and bis(3-ethoxysilylpropyl)disulfide. The nanosystems present the long-range order of the hexagonal nanostructure. They are degraded in simulated physiological conditions. The loading and release of doxorubicin with these nanosystems are both pH dependent. These nanoparticles are endocytosed by breast cancer cells and are very efficient for doxorubicin delivery in these cells.
authors.affiliation: Institut Charles Gerhardt Montpellier, UMR-5253 CNRS-UM2-ENSCM-UM1cc 1701, Place Eugène Bataillon, F-34095, Montpellier cedex 05, France.
authors.forename: Jonas
authors.initials: J
authors.lastname: Croissant
authors.forename: Xavier
authors.initials: X
authors.lastname: Cattoën
authors.forename: Michel Wong Chi
authors.initials: MW
authors.lastname: Man
authors.forename: Audrey
authors.initials: A
authors.lastname: Gallud
authors.forename: Laurence
authors.initials: L
authors.lastname: Raehm
authors.forename: Philippe
authors.initials: P
authors.lastname: Trens
authors.forename: Marie
authors.initials: M
authors.lastname: Maynadier
authors.forename: Jean-Olivier
authors.initials: JO
authors.lastname: Durand
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D004220:Disulfides / Q000737:chemistry*; D004317:Doxorubicin / Q000737:chemistry / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism; D005030:Ethylenes / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D061986:MCF-7 Cells; D054118:Nanospheres / Q000737:chemistry*; D043942:Nanotubes / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D000903:Antibiotics, Antineoplastic; D004220:Disulfides; D004337:Drug Carriers; D005030:Ethylenes; D012822:Silicon Dioxide; D004317:Doxorubicin; C036216:ethylene
keywords: biodegradable; cancer; disulfide; drug delivery; nanoparticles; periodic mesoporous organosilica