title: Associations between TNFSF15 polymorphisms and susceptibility to ulcerative colitis and Crohn's disease: A meta-analysis.
abstract: OBJECTIVE
  Several polymorphisms have been identified in TNFSF15, while their roles in the incidence of ulcerative colitis (UC) and Crohn's disease (CD) are conflicting. This meta-analysis was aimed to clarify the impact of these polymorphisms on UC and CD risk.
  
  
  METHODS
  Databases were searched until 31 January 2014 for eligible studies on TNFSF15 polymorphisms. Data were extracted, and pooled odd ratios (ORs) as well as 95% confidence intervals (95% CIs) were calculated.
  
  
  RESULTS
  Fifteen studies with 8903 CD patients, 4687 UC patients and 12 606 controls were included. Except for rs4263839 polymorphism, significant associations were found between the rest six TNFSF15 polymorphisms and CD risk (rs3810936: OR = 2.10, 95% CI, 1.47-3.00; rs6478108: OR = 2.19, 95% CI, 1.53-3.13; rs4979462: OR = 1.89, 95% CI, 1.42-2.52; rs6478109: OR = 2.00, 95% CI, 1.39-2.88; rs7848647: OR = 1.54, 95% CI, 1.15-2.06; rs7869487: OR = 1.51, 95% CI, 1.06-2.17). And we found rs3810936, rs6478108 and rs6478109 polymorphism were significantly associated with UC risk (rs3810936: OR = 1.19, 95% CI, 1.06-1.34; rs6478108: OR = 1.16, 95% CI, 1.06-1.26; rs6478109: OR = 1.16, 95% CI, 1.03-1.32). According to the subgroup analysis by ethnicity, except for rs4263839 in Caucasian and rs4979462 in Asian, all the rest investigated TNFSF15 polymorphisms were associated with CD risk and rs3810936 and rs7848647 polymorphism in Asian as well as rs6478108 polymorphism in Caucasian were associated with UC risk.
  
  
  CONCLUSIONS
  This meta-analysis indicated that most of the seven TNFSF15 polymorphisms (except for rs4263839) were risk factors contributed to CD and UC susceptibility. The differences in ethnicity did not influence the risk obviously.
authors.affiliation: Department of Gastroenterology, Renmin Hospital of Wuhan University , Wuhan, Hubei Province , China and.
authors.forename: Jixiang
authors.initials: J
authors.lastname: Zhang
authors.forename: Jihui
authors.initials: J
authors.lastname: Zhang
authors.forename: Dandan
authors.initials: D
authors.lastname: Wu
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Weiguo
authors.initials: W
authors.lastname: Dong
mesh_terms: D044466:Asian People / Q000235:genetics; D003093:Colitis, Ulcerative / Q000235:genetics* / Q000276:immunology; D016001:Confidence Intervals; D003424:Crohn Disease / Q000235:genetics* / Q000276:immunology; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D053380:Tumor Necrosis Factor Ligand Superfamily Member 15 / Q000235:genetics* / Q000276:immunology; D044465:White People / Q000235:genetics
chemical_list: C117026:TNFSF15 protein, human; D053380:Tumor Necrosis Factor Ligand Superfamily Member 15
keywords: Crohn's disease; TNFSF15; meta-analysis; polymorphisms; ulcerative colitis