title: When fate follows age: unequal centrosomes in asymmetric cell division.
abstract: A strong correlation between centrosome age and fate has been reported in some stem cells and progenitors that divide asymmetrically. In some cases, such stereotyped centrosome behaviour is essential to endow stemness to only one of the two daughters, whereas in other cases causality is still uncertain. Here, we present the different cell types in which correlated centrosome age and fate has been documented, review current knowledge on the underlying molecular mechanisms and discuss possible functional implications of this process.
authors.affiliation: Institute for Research in Biomedicine (IRB-Barcelona), Baldiri Reixac 10, Barcelona 08028, Spain.
authors.forename: Jose
authors.initials: J
authors.lastname: Reina
authors.affiliation: Institute for Research in Biomedicine (IRB-Barcelona), Baldiri Reixac 10, Barcelona 08028, Spain Institució Catalana de Recerca i Estudis Avançats (ICREA), Passeig Lluís Companys 23, Barcelona 08010, Spain gonzalez@irbbarcelona.org.
authors.forename: Cayetano
authors.initials: C
authors.lastname: Gonzalez
mesh_terms: D000367:Age Factors; D000818:Animals; D060049:Asymmetric Cell Division / Q000502:physiology*; D002502:Centrioles / Q000502:physiology*; D018385:Centrosome / Q000502:physiology*; D004330:Drosophila; D006801:Humans; D051379:Mice; D008954:Models, Biological; D013234:Stem Cells / Q000502:physiology*
keywords: asymmetric cell division; centriole; centrosome; stem cell