title: Hydro-methanolic extract of cornus MAS L. And blood glucose, lipid profile and hematological parameters of male rats.
abstract: BACKGROUND
  Cornus mas L, an olive-shaped red-colored single-seeded fruit, is used in traditional medicine in different parts of Europe and Asia.
  
  
  OBJECTIVE
  In the present study, 40 male Wistar rats were randomly divided into five groups, and the effects of 21 days of intraperitoneally (IP) administration of 50, 200 and 400 mg/kg body weight of C. mas hydro-methanolic extract on the rats hematological and biochemical parameters were investigated. The experimental study was carried out in Tabriz, Iran.
  
  
  METHODS
  The hematology and biochemical tests were performed by the Technicon H1 Hematology Analyzer and enzymatic methods, respectively.
  
  
  RESULTS
  The results indicated that all doses of the extract caused significant (P < 0.05) decreases in the hemoglobin distribution width (HDW) (2.3 ± 0.2 vs. 2.5 ± 0.2, P = 0.049) and platelet distribution width (PDW) (56.5 ± 1.8 vs. 63.9 ± 3.6, P = 0.001) of the treated groups vs. control group, whereas only high doses caused significant elevation in the mean corpuscular hemoglobin concentration (MCHC) (30.3 ± 0.8 vs. 28.6 ± 0.6, P = 0.047), mean platelet volume (MPV) (5.0 ± 0.6 vs. 4.1 ± 0.3, P = 0.002), total platelet mass (PCT) (0.33 ± 0.07 vs. 0.26 ± 0.01, P = 0.050), and significant decrease in the red cell distribution width (RDW) (13.8 ± 0.4 vs. 14.7 ± 1.3, P = 0.048) of the treated groups vs. control group.
  
  
  CONCLUSIONS
  Decreasing effect of the extract on platelet activity might classify it as an alternative for antiplatelet therapy in cardiovascular diseases (CVD). The results of this study suggested that further investigations with higher doses of C. mas fruit extract are necessary to obtain significant protective and nonprotective changes in hematological and biochemical parameters.
authors.affiliation: Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, IR Iran.
authors.forename: Bita
authors.initials: B
authors.lastname: Abdollahi
authors.affiliation: Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, IR Iran ; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, IR Iran.
authors.forename: Mehran
authors.initials: M
authors.lastname: Mesgari Abbasi
authors.affiliation: Student Research Committee, Tabriz University of Medical Sciences, Tabriz, IR Iran.
authors.forename: Parvin
authors.initials: P
authors.lastname: Zakeri Milani
authors.affiliation: Medical Education Research Center, Tabriz University of Medical Sciences, Tabriz, IR Iran.
authors.forename: Ashraf Sadat
authors.initials: AS
authors.lastname: Nourdadgar
authors.affiliation: Department of Natural Sciences, Faculty of Natural Sciences, University of Tabriz, Tabriz, IR Iran.
authors.forename: Seyyed Mehdi
authors.initials: SM
authors.lastname: Banan Khojasteh
authors.affiliation: Faculty of Science, Urmia University, Urmia, IR Iran.
authors.forename: Vahid
authors.initials: V
authors.lastname: Nejati
keywords: Biological Markers; Blood Glucose; Cornus; Hematologic Tests