title: Serum paraoxonase, TAS, TOS and ceruloplasmin in brucellosis.
abstract: It is possible that brucellosis may be related to increase free radical production and antioxidant depletion. Thus, in the present study we aimed to evaluate the oxidative status in patient with brucellosis and healthy controls.
  
  
  METHODS
  This study includes the patients with brucellosis diagnosed by clinical findings and positive agglutination titer. The paraoxonase, ceruloplasmin, total antioxidant capacity and total oxidant status values were measured from the samples taken. The oxidative stress index value was calculated through the total antioxidant capacity and total oxidant status values.
  
  
  RESULTS
  A total number of 93 people, 40 women (43%) and 53 men (57%) were included to the study. The levels of ceruloplasmin were found higher in patients when compared to the control group (p < 0.001). The total antioxidant capacity level was found significantly higher in the patients group when compared to the control group (p < 0.001). The oxidative stress index value was significantly lower in the patients group when compared to the control group (p < 0.001). The paraoxonase-1 level was not different in control and patient groups (p = 0.077).
  
  
  CONCLUSIONS
  Brucellosis is an infection that is frequently seen in Mediterranean countries. This infection breaks the oxidant and antioxidant balance. In this disease, oxidant-antioxidant system indicators such as ceruloplasmin, total antioxidant capacity, total oxidant status and oxidative stress index can be used for showing the role of the brucella infection and for the monitoring of the treatment results.
authors.affiliation: Department of Biochemistry, Dicle University Faculty of Medicine Diyarbakır, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Demirpençe
authors.affiliation: Department of Biochemistry, Dicle University Faculty of Medicine Diyarbakır, Turkey.
authors.forename: Bünyamin
authors.initials: B
authors.lastname: Sevim
authors.affiliation: Department of Medical Oncology, Ministry of Health Batman Regional Govermant Hospital Batman, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yıldırım
authors.affiliation: Department of Biochemistry, Ministry of Health Gaziosmanpaşa Taksim Education and Research Hospital Istanbul Turkey.
authors.forename: Nilhan
authors.initials: N
authors.lastname: Ayan Nurlu
authors.affiliation: Department Enfection Disease and Clinical Microbiology, Ministry of Health Batman Regional Govermant Hospital Batman, Turkey.
authors.forename: Duygu
authors.initials: D
authors.lastname: Mert
authors.affiliation: Department of Biochemistry, Dicle University Faculty of Medicine Diyarbakır, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Evliyaoğlu
keywords: Brucella; ceruloplasmin; paraoxonase; total antioxidant capacity; total oxidant status