title: Monosomal karyotype predicts adverse prognosis in patients diagnosed with chronic myelomonocytic leukemia: a single-institution experience.
abstract: BACKGROUND
  Cytogenetic abnormalities have a significant prognostic effect in many hematologic neoplasms. Monosomal karyotype (MK), a newly recognized cytogenetic category, has been reported to be a marker of poor prognosis in patients with myelodysplastic syndromes and myelofibrosis, but its effect in chronic myelomonocytic leukemia (CMML) remains relatively unknown.
  
  
  METHODS
  A retrospective study of cases diagnosed with CMML found a total of 262 patients. Patient characteristics, cytogenetic data, and survival were analyzed.
  
  
  RESULTS
  Cytogenetic analysis found diploidy in 167 patients (64%). Trisomy 8 was the most frequent cytogenetic abnormality at 8% (22), followed by complex karyotype (CK) at 5% (14), (-)7 at 4% (10), and MK at 3% (7, of which 6 [86%] were also CK). Median overall survival was statistically significantly worse in MK-positive cases than in MK-negative cases (MK(+) vs. MK(-)). Patients with MK(+) only or CK(+)MK(+) did worse than any other group.
  
  
  CONCLUSIONS
  MK is a rare entity but can predict statistically significantly shorter overall survival among all other cytogenetic categories.
authors.affiliation: Division of Hematology, Mayo Clinic, Rochester, MN.
authors.forename: Aysha
authors.initials: A
authors.lastname: Alsahlawi
authors.affiliation: Division of Hematology, Mayo Clinic, Rochester, MN.
authors.forename: Hassan
authors.initials: H
authors.lastname: Alkhateeb
authors.affiliation: Division of Hematology, Mayo Clinic, Rochester, MN.
authors.forename: Mrinal
authors.initials: M
authors.lastname: Patnaik
authors.affiliation: Division of Hematology, Mayo Clinic, Rochester, MN.
authors.forename: Kebede
authors.initials: K
authors.lastname: Begna
authors.affiliation: Division of Hematology, Mayo Clinic, Rochester, MN.
authors.forename: Michelle
authors.initials: M
authors.lastname: Elliott
authors.affiliation: Division of Hematology, Mayo Clinic, Rochester, MN.
authors.forename: William J
authors.initials: WJ
authors.lastname: Hogan
authors.affiliation: Division of Hematology, Mayo Clinic, Rochester, MN.
authors.forename: Mark
authors.initials: M
authors.lastname: Litzow
authors.affiliation: Division of Hematology, Mayo Clinic, Rochester, MN. Electronic address: alkali.aref@mayo.edu.
authors.forename: Aref
authors.initials: A
authors.lastname: Al-Kali
mesh_terms: D000368:Aged; D015331:Cohort Studies; D003582:Cytogenetics; D005260:Female; D006801:Humans; D059785:Karyotype; D015477:Leukemia, Myelomonocytic, Chronic / Q000235:genetics*; D008297:Male; D009006:Monosomy; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis
keywords: CMML; Cytogenetic analysis; MK; Prognosis; Survival