title: An integration of condensation/Ullmann-type coupling/bicyclization sequences: copper-catalyzed three-component direct synthesis of [1,2,4]triazolo[1,5-b]isoquinolin-5(1H)-ones.
abstract: A highly efficient three-component domino protocol has been developed for the synthesis of [1,2,4]triazolo[1,5-b]isoquinolin-5(1H)-ones from simple and readily available o-halogenated benzohydrazides, aldehydes and nitriles. This domino process involves sequential selective condensation, copper-catalyzed intermolecular C-arylation and bicyclization. Notably, the use of ligands and anaerobic conditions can be avoided in this reaction.
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China. chwuax@mail.ccnu.edu.cn.
authors.forename: Feng-Cheng
authors.initials: FC
authors.lastname: Jia
authors.forename: Cheng
authors.initials: C
authors.lastname: Xu
authors.forename: Qun
authors.initials: Q
authors.lastname: Cai
authors.forename: An-Xin
authors.initials: AX
authors.lastname: Wu
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D001555:Benzene Derivatives / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D054879:Halogenation; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D009570:Nitriles / Q000737:chemistry; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000447:Aldehydes; D001555:Benzene Derivatives; D007546:Isoquinolines; D009570:Nitriles; D014230:Triazoles; D003300:Copper