title: Emphysematous pancreatitis predisposed by Olanzapine.
abstract: A 32-year-old male presented to our intensive care unit with severe abdominal pain and was diagnosed as acute pancreatitis after 2 months of olanzapine therapy for bipolar disorder. His serum lipase was 900 u/L, serum triglyceride 560 mg/dL, and blood sugar, fasting and postprandial were 230 and 478 mg/dL, respectively on admission. Contrast enhanced computed tomography (CECT) of abdomen was suggestive of acute pancreatitis. Repeat CECT showed gas inside pancreas and collection in peripancreatic area and patient underwent percutaneous drainage and antibiotics irrigation through the drain into pancreas. We describe the rare case of emphysematous pancreatitis due to development of diabetes, hypertriglyceridemia and immunosuppression predisposed by short duration olanzapine therapy.
authors.affiliation: Department of Anesthesia and Critical Care (Trauma Centre), JPNA Trauma Centre, AIIMS, New Delhi, India.
authors.forename: Sukhen
authors.initials: S
authors.lastname: Samanta
authors.affiliation: Department of Critical Care Medicine, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
authors.forename: Sujay
authors.initials: S
authors.lastname: Samanta
authors.affiliation: Department of General Medicine, Darbhanga Medical College and Hospital, Darbhanga, Bihar, India.
authors.forename: Krishanu
authors.initials: K
authors.lastname: Banik
authors.affiliation: Department of Critical Care Medicine, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
authors.forename: Arvind Kumar
authors.initials: AK
authors.lastname: Baronia
keywords: Emphysematous pancreatitis; local metronidazole application; olanzapine