title: Comparing five different iterative reconstruction algorithms for computed tomography in an ROC study.
abstract: OBJECTIVE
  The purpose of this study was to evaluate lesion conspicuity achieved with five different iterative reconstruction techniques from four CT vendors at three different dose levels. Comparisons were made of iterative algorithm and filtered back projection (FBP) among and within systems.
  
  
  METHODS
  An anthropomorphic liver phantom was examined with four CT systems, each from a different vendor. CTDIvol levels of 5 mGy, 10 mGy and 15 mGy were chosen. Images were reconstructed with FBP and the iterative algorithm on the system. Images were interpreted independently by four observers, and the areas under the ROC curve (AUCs) were calculated. Noise and contrast-to-noise ratios (CNR) were measured.
  
  
  RESULTS
  One iterative algorithm increased AUC (0.79, 0.95, and 0.97) compared to FBP (0.70, 0.86, and 0.93) at all dose levels (p < 0.001 and p = 0.047). Another algorithm increased AUC from 0.78 with FBP to 0.84 (p = 0.007) at 5 mGy. Differences at 10 and 15 mGy were not significant (p-values: 0.084-0.883). Three algorithms showed no difference in AUC compared to FBP (p-values: 0.008-1.000). All of the algorithms decreased noise (10-71%) and improved CNR.
  
  
  CONCLUSIONS
  Only two algorithms improved lesion detection, even though noise reduction was shown with all algorithms.
  
  
  CONCLUSIONS
  Iterative reconstruction algorithms affected lesion detection differently at different dose levels. One iterative algorithm improved lesion detectability compared to filtered back projection. Three algorithms did not significantly improve lesion detectability. One algorithm improved lesion detectability at the lowest dose level.
authors.affiliation: The Intervention Centre, Rikshospitalet, Postboks 4950, Nydalen, 0424, Oslo, Norway, uxjekr@ous-hf.no.
authors.forename: Kristin
authors.initials: K
authors.lastname: Jensen
authors.forename: Anne Catrine T
authors.initials: AC
authors.lastname: Martinsen
authors.forename: Anders
authors.initials: A
authors.lastname: Tingberg
authors.forename: Trond Mogens
authors.initials: TM
authors.lastname: Aaløkken
authors.forename: Erik
authors.initials: E
authors.lastname: Fosse
mesh_terms: D000465:Algorithms; D003287:Contrast Media; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging*; D015588:Observer Variation; D019047:Phantoms, Imaging; D012372:ROC Curve; D011829:Radiation Dosage; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media