title: Longterm retention rate and risk factor for discontinuation due to insufficient efficacy and adverse events in Japanese patients with rheumatoid arthritis receiving etanercept therapy.
abstract: OBJECTIVE
  Assessing retention rate and risk factor for drug discontinuation is important for drug evaluation. We examined a 3-year retention rate and the risk factor for discontinuation due to insufficient efficacy (IE) and adverse events (AE) in Japanese patients with rheumatoid arthritis (RA) who are receiving etanercept (ETN).
  
  
  METHODS
  Data were collected from 588 patients treated with ETN as a first biologic from the Tsurumai Biologics Communication Registry. Baseline characteristics for the incidence of both IE and AE were analyzed using the Cox proportional-hazards regression model. Patients were divided into groups based on age and concomitant methotrexate (MTX). Drug retention rates were calculated using the Kaplan-Meier method and compared among groups using the log-rank test.
  
  
  RESULTS
  ETN monotherapy without concomitant MTX [MTX(-)] was significantly related to a higher incidence of discontinuation due to IE [hazard ratio (HR) = 2.226, 95% CI 1.363-3.634]. Older age and MTX(-) were significantly related to a higher incidence of discontinuation due to AE [HR = 1.040, 1.746, 95% CI 1.020-1.060, 1.103-2.763, respectively]. The MTX(-)/≥ 65 years group had the lowest retention rate (p < 0.001). The discontinuation rate due to IE was lower in the MTX(+)/< 65 years group compared to < 65 years/MTX(-), ≥ 65 years/MTX(-) group (p = 0.006, p < 0.001, respectively). The discontinuation rate due to AE was highest in the MTX(-)/≥ 65 years group (p < 0.001).
  
  
  CONCLUSIONS
  Our findings suggest that the risk of discontinuation due to IE was high in the patients who did not use concomitant MTX and that the risk of discontinuation due to AE was high in elderly patients who did not use concomitant MTX.
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; Department of Orthopedic Surgery, Nagoya Medical Center; Department of Orthopedic Surgery, Nagoya Central Hospital, Nagoya; Department of Rheumatology, Tokyo Koseinenkin Hospital, Tokyo; Ito Orthopedic Clinic, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota; Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Shizuoka; Department of Orthopedic Surgery, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan, Japan.H. Matsubara, MD; T. Kojima, MD; N. Takahashi, MD; K. Funahashi, MD; D. Kato, MD; M. Hanabayashi, MD; K. Terabe, MD; N. Ishiguro, MD, Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; A. Kaneko, MD; H. Ishikawa, MD; Y. Hattori, MD, Department of Orthopedic Surgery, Nagoya Medical Center; Y. Hirano, MD, Department of Rheumatology, Toyohashi Municipal Hospital; H. Miyake, MD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Oguchi, MD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Takagi, MD, Department of Orthopedic Surgery, Nagoya Central Hospital; Y. Yabe, MD, Department of Rheumatology, Tokyo Koseinenkin Hospital; T. Kato, MD, Kato Orthopedic Clinic; T. Ito, MD, Ito Orthopedic Clinic; N. Fukaya, MD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; Y. Kanayama, MD, Department of Orthopedic Surgery, Toyota Kosei Hospital; T. Shioura, MD, Department of Orthopedic Surgery, Shizuoka Kosei Hospital; M. Hayashi, MD, Department of Orthopedic Surgery, Nagano Red Cross Hospital; T. Fujibayashi, MD, Dep
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Matsubara
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; Department of Orthopedic Surgery, Nagoya Medical Center; Department of Orthopedic Surgery, Nagoya Central Hospital, Nagoya; Department of Rheumatology, Tokyo Koseinenkin Hospital, Tokyo; Ito Orthopedic Clinic, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota; Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Shizuoka; Department of Orthopedic Surgery, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan, Japan.H. Matsubara, MD; T. Kojima, MD; N. Takahashi, MD; K. Funahashi, MD; D. Kato, MD; M. Hanabayashi, MD; K. Terabe, MD; N. Ishiguro, MD, Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; A. Kaneko, MD; H. Ishikawa, MD; Y. Hattori, MD, Department of Orthopedic Surgery, Nagoya Medical Center; Y. Hirano, MD, Department of Rheumatology, Toyohashi Municipal Hospital; H. Miyake, MD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Oguchi, MD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Takagi, MD, Department of Orthopedic Surgery, Nagoya Central Hospital; Y. Yabe, MD, Department of Rheumatology, Tokyo Koseinenkin Hospital; T. Kato, MD, Kato Orthopedic Clinic; T. Ito, MD, Ito Orthopedic Clinic; N. Fukaya, MD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; Y. Kanayama, MD, Department of Orthopedic Surgery, Toyota Kosei Hospital; T. Shioura, MD, Department of Orthopedic Surgery, Shizuoka Kosei Hospital; M. Hayashi, MD, Department of Orthopedic Surgery, Nagano Red Cross Hospital; T. Fujibayashi, MD, Dep
authors.forename: Toshihisa
authors.initials: T
authors.lastname: Kojima
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; Department of Orthopedic Surgery, Nagoya Medical Center; Department of Orthopedic Surgery, Nagoya Central Hospital, Nagoya; Department of Rheumatology, Tokyo Koseinenkin Hospital, Tokyo; Ito Orthopedic Clinic, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota; Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Shizuoka; Department of Orthopedic Surgery, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan, Japan.H. Matsubara, MD; T. Kojima, MD; N. Takahashi, MD; K. Funahashi, MD; D. Kato, MD; M. Hanabayashi, MD; K. Terabe, MD; N. Ishiguro, MD, Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; A. Kaneko, MD; H. Ishikawa, MD; Y. Hattori, MD, Department of Orthopedic Surgery, Nagoya Medical Center; Y. Hirano, MD, Department of Rheumatology, Toyohashi Municipal Hospital; H. Miyake, MD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Oguchi, MD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Takagi, MD, Department of Orthopedic Surgery, Nagoya Central Hospital; Y. Yabe, MD, Department of Rheumatology, Tokyo Koseinenkin Hospital; T. Kato, MD, Kato Orthopedic Clinic; T. Ito, MD, Ito Orthopedic Clinic; N. Fukaya, MD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; Y. Kanayama, MD, Department of Orthopedic Surgery, Toyota Kosei Hospital; T. Shioura, MD, Department of Orthopedic Surgery, Shizuoka Kosei Hospital; M. Hayashi, MD, Department of Orthopedic Surgery, Nagano Red Cross Hospital; T. Fujibayashi, MD, Dep
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kaneko
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; Department of Orthopedic Surgery, Nagoya Medical Center; Department of Orthopedic Surgery, Nagoya Central Hospital, Nagoya; Department of Rheumatology, Tokyo Koseinenkin Hospital, Tokyo; Ito Orthopedic Clinic, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota; Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Shizuoka; Department of Orthopedic Surgery, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan, Japan.H. Matsubara, MD; T. Kojima, MD; N. Takahashi, MD; K. Funahashi, MD; D. Kato, MD; M. Hanabayashi, MD; K. Terabe, MD; N. Ishiguro, MD, Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; A. Kaneko, MD; H. Ishikawa, MD; Y. Hattori, MD, Department of Orthopedic Surgery, Nagoya Medical Center; Y. Hirano, MD, Department of Rheumatology, Toyohashi Municipal Hospital; H. Miyake, MD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Oguchi, MD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Takagi, MD, Department of Orthopedic Surgery, Nagoya Central Hospital; Y. Yabe, MD, Department of Rheumatology, Tokyo Koseinenkin Hospital; T. Kato, MD, Kato Orthopedic Clinic; T. Ito, MD, Ito Orthopedic Clinic; N. Fukaya, MD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; Y. Kanayama, MD, Department of Orthopedic Surgery, Toyota Kosei Hospital; T. Shioura, MD, Department of Orthopedic Surgery, Shizuoka Kosei Hospital; M. Hayashi, MD, Department of Orthopedic Surgery, Nagano Red Cross Hospital; T. Fujibayashi, MD, Dep
authors.forename: Yuji
authors.initials: Y
authors.lastname: Hirano
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; Department of Orthopedic Surgery, Nagoya Medical Center; Department of Orthopedic Surgery, Nagoya Central Hospital, Nagoya; Department of Rheumatology, Tokyo Koseinenkin Hospital, Tokyo; Ito Orthopedic Clinic, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota; Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Shizuoka; Department of Orthopedic Surgery, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan, Japan.H. Matsubara, MD; T. Kojima, MD; N. Takahashi, MD; K. Funahashi, MD; D. Kato, MD; M. Hanabayashi, MD; K. Terabe, MD; N. Ishiguro, MD, Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; A. Kaneko, MD; H. Ishikawa, MD; Y. Hattori, MD, Department of Orthopedic Surgery, Nagoya Medical Center; Y. Hirano, MD, Department of Rheumatology, Toyohashi Municipal Hospital; H. Miyake, MD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Oguchi, MD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Takagi, MD, Department of Orthopedic Surgery, Nagoya Central Hospital; Y. Yabe, MD, Department of Rheumatology, Tokyo Koseinenkin Hospital; T. Kato, MD, Kato Orthopedic Clinic; T. Ito, MD, Ito Orthopedic Clinic; N. Fukaya, MD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; Y. Kanayama, MD, Department of Orthopedic Surgery, Toyota Kosei Hospital; T. Shioura, MD, Department of Orthopedic Surgery, Shizuoka Kosei Hospital; M. Hayashi, MD, Department of Orthopedic Surgery, Nagano Red Cross Hospital; T. Fujibayashi, MD, Dep
authors.forename: Hisato
authors.initials: H
authors.lastname: Ishikawa
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; Department of Orthopedic Surgery, Nagoya Medical Center; Department of Orthopedic Surgery, Nagoya Central Hospital, Nagoya; Department of Rheumatology, Tokyo Koseinenkin Hospital, Tokyo; Ito Orthopedic Clinic, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota; Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Shizuoka; Department of Orthopedic Surgery, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan, Japan.H. Matsubara, MD; T. Kojima, MD; N. Takahashi, MD; K. Funahashi, MD; D. Kato, MD; M. Hanabayashi, MD; K. Terabe, MD; N. Ishiguro, MD, Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; A. Kaneko, MD; H. Ishikawa, MD; Y. Hattori, MD, Department of Orthopedic Surgery, Nagoya Medical Center; Y. Hirano, MD, Department of Rheumatology, Toyohashi Municipal Hospital; H. Miyake, MD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Oguchi, MD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Takagi, MD, Department of Orthopedic Surgery, Nagoya Central Hospital; Y. Yabe, MD, Department of Rheumatology, Tokyo Koseinenkin Hospital; T. Kato, MD, Kato Orthopedic Clinic; T. Ito, MD, Ito Orthopedic Clinic; N. Fukaya, MD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; Y. Kanayama, MD, Department of Orthopedic Surgery, Toyota Kosei Hospital; T. Shioura, MD, Department of Orthopedic Surgery, Shizuoka Kosei Hospital; M. Hayashi, MD, Department of Orthopedic Surgery, Nagano Red Cross Hospital; T. Fujibayashi, MD, Dep
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Hattori
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; Department of Orthopedic Surgery, Nagoya Medical Center; Department of Orthopedic Surgery, Nagoya Central Hospital, Nagoya; Department of Rheumatology, Tokyo Koseinenkin Hospital, Tokyo; Ito Orthopedic Clinic, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota; Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Shizuoka; Department of Orthopedic Surgery, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan, Japan.H. Matsubara, MD; T. Kojima, MD; N. Takahashi, MD; K. Funahashi, MD; D. Kato, MD; M. Hanabayashi, MD; K. Terabe, MD; N. Ishiguro, MD, Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; A. Kaneko, MD; H. Ishikawa, MD; Y. Hattori, MD, Department of Orthopedic Surgery, Nagoya Medical Center; Y. Hirano, MD, Department of Rheumatology, Toyohashi Municipal Hospital; H. Miyake, MD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Oguchi, MD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Takagi, MD, Department of Orthopedic Surgery, Nagoya Central Hospital; Y. Yabe, MD, Department of Rheumatology, Tokyo Koseinenkin Hospital; T. Kato, MD, Kato Orthopedic Clinic; T. Ito, MD, Ito Orthopedic Clinic; N. Fukaya, MD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; Y. Kanayama, MD, Department of Orthopedic Surgery, Toyota Kosei Hospital; T. Shioura, MD, Department of Orthopedic Surgery, Shizuoka Kosei Hospital; M. Hayashi, MD, Department of Orthopedic Surgery, Nagano Red Cross Hospital; T. Fujibayashi, MD, Dep
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Miyake
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; Department of Orthopedic Surgery, Nagoya Medical Center; Department of Orthopedic Surgery, Nagoya Central Hospital, Nagoya; Department of Rheumatology, Tokyo Koseinenkin Hospital, Tokyo; Ito Orthopedic Clinic, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota; Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Shizuoka; Department of Orthopedic Surgery, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan, Japan.H. Matsubara, MD; T. Kojima, MD; N. Takahashi, MD; K. Funahashi, MD; D. Kato, MD; M. Hanabayashi, MD; K. Terabe, MD; N. Ishiguro, MD, Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; A. Kaneko, MD; H. Ishikawa, MD; Y. Hattori, MD, Department of Orthopedic Surgery, Nagoya Medical Center; Y. Hirano, MD, Department of Rheumatology, Toyohashi Municipal Hospital; H. Miyake, MD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Oguchi, MD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Takagi, MD, Department of Orthopedic Surgery, Nagoya Central Hospital; Y. Yabe, MD, Department of Rheumatology, Tokyo Koseinenkin Hospital; T. Kato, MD, Kato Orthopedic Clinic; T. Ito, MD, Ito Orthopedic Clinic; N. Fukaya, MD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; Y. Kanayama, MD, Department of Orthopedic Surgery, Toyota Kosei Hospital; T. Shioura, MD, Department of Orthopedic Surgery, Shizuoka Kosei Hospital; M. Hayashi, MD, Department of Orthopedic Surgery, Nagano Red Cross Hospital; T. Fujibayashi, MD, Dep
authors.forename: Takeshi
authors.initials: T
authors.lastname: Oguchi
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; Department of Orthopedic Surgery, Nagoya Medical Center; Department of Orthopedic Surgery, Nagoya Central Hospital, Nagoya; Department of Rheumatology, Tokyo Koseinenkin Hospital, Tokyo; Ito Orthopedic Clinic, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota; Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Shizuoka; Department of Orthopedic Surgery, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan, Japan.H. Matsubara, MD; T. Kojima, MD; N. Takahashi, MD; K. Funahashi, MD; D. Kato, MD; M. Hanabayashi, MD; K. Terabe, MD; N. Ishiguro, MD, Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; A. Kaneko, MD; H. Ishikawa, MD; Y. Hattori, MD, Department of Orthopedic Surgery, Nagoya Medical Center; Y. Hirano, MD, Department of Rheumatology, Toyohashi Municipal Hospital; H. Miyake, MD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Oguchi, MD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Takagi, MD, Department of Orthopedic Surgery, Nagoya Central Hospital; Y. Yabe, MD, Department of Rheumatology, Tokyo Koseinenkin Hospital; T. Kato, MD, Kato Orthopedic Clinic; T. Ito, MD, Ito Orthopedic Clinic; N. Fukaya, MD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; Y. Kanayama, MD, Department of Orthopedic Surgery, Toyota Kosei Hospital; T. Shioura, MD, Department of Orthopedic Surgery, Shizuoka Kosei Hospital; M. Hayashi, MD, Department of Orthopedic Surgery, Nagano Red Cross Hospital; T. Fujibayashi, MD, Dep
authors.forename: Hideki
authors.initials: H
authors.lastname: Takagi
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; Department of Orthopedic Surgery, Nagoya Medical Center; Department of Orthopedic Surgery, Nagoya Central Hospital, Nagoya; Department of Rheumatology, Tokyo Koseinenkin Hospital, Tokyo; Ito Orthopedic Clinic, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota; Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Shizuoka; Department of Orthopedic Surgery, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan, Japan.H. Matsubara, MD; T. Kojima, MD; N. Takahashi, MD; K. Funahashi, MD; D. Kato, MD; M. Hanabayashi, MD; K. Terabe, MD; N. Ishiguro, MD, Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; A. Kaneko, MD; H. Ishikawa, MD; Y. Hattori, MD, Department of Orthopedic Surgery, Nagoya Medical Center; Y. Hirano, MD, Department of Rheumatology, Toyohashi Municipal Hospital; H. Miyake, MD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Oguchi, MD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Takagi, MD, Department of Orthopedic Surgery, Nagoya Central Hospital; Y. Yabe, MD, Department of Rheumatology, Tokyo Koseinenkin Hospital; T. Kato, MD, Kato Orthopedic Clinic; T. Ito, MD, Ito Orthopedic Clinic; N. Fukaya, MD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; Y. Kanayama, MD, Department of Orthopedic Surgery, Toyota Kosei Hospital; T. Shioura, MD, Department of Orthopedic Surgery, Shizuoka Kosei Hospital; M. Hayashi, MD, Department of Orthopedic Surgery, Nagano Red Cross Hospital; T. Fujibayashi, MD, Dep
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Yabe
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; Department of Orthopedic Surgery, Nagoya Medical Center; Department of Orthopedic Surgery, Nagoya Central Hospital, Nagoya; Department of Rheumatology, Tokyo Koseinenkin Hospital, Tokyo; Ito Orthopedic Clinic, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota; Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Shizuoka; Department of Orthopedic Surgery, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan, Japan.H. Matsubara, MD; T. Kojima, MD; N. Takahashi, MD; K. Funahashi, MD; D. Kato, MD; M. Hanabayashi, MD; K. Terabe, MD; N. Ishiguro, MD, Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; A. Kaneko, MD; H. Ishikawa, MD; Y. Hattori, MD, Department of Orthopedic Surgery, Nagoya Medical Center; Y. Hirano, MD, Department of Rheumatology, Toyohashi Municipal Hospital; H. Miyake, MD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Oguchi, MD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Takagi, MD, Department of Orthopedic Surgery, Nagoya Central Hospital; Y. Yabe, MD, Department of Rheumatology, Tokyo Koseinenkin Hospital; T. Kato, MD, Kato Orthopedic Clinic; T. Ito, MD, Ito Orthopedic Clinic; N. Fukaya, MD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; Y. Kanayama, MD, Department of Orthopedic Surgery, Toyota Kosei Hospital; T. Shioura, MD, Department of Orthopedic Surgery, Shizuoka Kosei Hospital; M. Hayashi, MD, Department of Orthopedic Surgery, Nagano Red Cross Hospital; T. Fujibayashi, MD, Dep
authors.forename: Takefumi
authors.initials: T
authors.lastname: Kato
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; Department of Orthopedic Surgery, Nagoya Medical Center; Department of Orthopedic Surgery, Nagoya Central Hospital, Nagoya; Department of Rheumatology, Tokyo Koseinenkin Hospital, Tokyo; Ito Orthopedic Clinic, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota; Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Shizuoka; Department of Orthopedic Surgery, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan, Japan.H. Matsubara, MD; T. Kojima, MD; N. Takahashi, MD; K. Funahashi, MD; D. Kato, MD; M. Hanabayashi, MD; K. Terabe, MD; N. Ishiguro, MD, Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; A. Kaneko, MD; H. Ishikawa, MD; Y. Hattori, MD, Department of Orthopedic Surgery, Nagoya Medical Center; Y. Hirano, MD, Department of Rheumatology, Toyohashi Municipal Hospital; H. Miyake, MD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Oguchi, MD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Takagi, MD, Department of Orthopedic Surgery, Nagoya Central Hospital; Y. Yabe, MD, Department of Rheumatology, Tokyo Koseinenkin Hospital; T. Kato, MD, Kato Orthopedic Clinic; T. Ito, MD, Ito Orthopedic Clinic; N. Fukaya, MD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; Y. Kanayama, MD, Department of Orthopedic Surgery, Toyota Kosei Hospital; T. Shioura, MD, Department of Orthopedic Surgery, Shizuoka Kosei Hospital; M. Hayashi, MD, Department of Orthopedic Surgery, Nagano Red Cross Hospital; T. Fujibayashi, MD, Dep
authors.forename: Takayasu
authors.initials: T
authors.lastname: Ito
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; Department of Orthopedic Surgery, Nagoya Medical Center; Department of Orthopedic Surgery, Nagoya Central Hospital, Nagoya; Department of Rheumatology, Tokyo Koseinenkin Hospital, Tokyo; Ito Orthopedic Clinic, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota; Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Shizuoka; Department of Orthopedic Surgery, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan, Japan.H. Matsubara, MD; T. Kojima, MD; N. Takahashi, MD; K. Funahashi, MD; D. Kato, MD; M. Hanabayashi, MD; K. Terabe, MD; N. Ishiguro, MD, Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; A. Kaneko, MD; H. Ishikawa, MD; Y. Hattori, MD, Department of Orthopedic Surgery, Nagoya Medical Center; Y. Hirano, MD, Department of Rheumatology, Toyohashi Municipal Hospital; H. Miyake, MD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Oguchi, MD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Takagi, MD, Department of Orthopedic Surgery, Nagoya Central Hospital; Y. Yabe, MD, Department of Rheumatology, Tokyo Koseinenkin Hospital; T. Kato, MD, Kato Orthopedic Clinic; T. Ito, MD, Ito Orthopedic Clinic; N. Fukaya, MD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; Y. Kanayama, MD, Department of Orthopedic Surgery, Toyota Kosei Hospital; T. Shioura, MD, Department of Orthopedic Surgery, Shizuoka Kosei Hospital; M. Hayashi, MD, Department of Orthopedic Surgery, Nagano Red Cross Hospital; T. Fujibayashi, MD, Dep
authors.forename: Naoki
authors.initials: N
authors.lastname: Fukaya
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; Department of Orthopedic Surgery, Nagoya Medical Center; Department of Orthopedic Surgery, Nagoya Central Hospital, Nagoya; Department of Rheumatology, Tokyo Koseinenkin Hospital, Tokyo; Ito Orthopedic Clinic, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota; Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Shizuoka; Department of Orthopedic Surgery, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan, Japan.H. Matsubara, MD; T. Kojima, MD; N. Takahashi, MD; K. Funahashi, MD; D. Kato, MD; M. Hanabayashi, MD; K. Terabe, MD; N. Ishiguro, MD, Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; A. Kaneko, MD; H. Ishikawa, MD; Y. Hattori, MD, Department of Orthopedic Surgery, Nagoya Medical Center; Y. Hirano, MD, Department of Rheumatology, Toyohashi Municipal Hospital; H. Miyake, MD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Oguchi, MD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Takagi, MD, Department of Orthopedic Surgery, Nagoya Central Hospital; Y. Yabe, MD, Department of Rheumatology, Tokyo Koseinenkin Hospital; T. Kato, MD, Kato Orthopedic Clinic; T. Ito, MD, Ito Orthopedic Clinic; N. Fukaya, MD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; Y. Kanayama, MD, Department of Orthopedic Surgery, Toyota Kosei Hospital; T. Shioura, MD, Department of Orthopedic Surgery, Shizuoka Kosei Hospital; M. Hayashi, MD, Department of Orthopedic Surgery, Nagano Red Cross Hospital; T. Fujibayashi, MD, Dep
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Kanayama
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; Department of Orthopedic Surgery, Nagoya Medical Center; Department of Orthopedic Surgery, Nagoya Central Hospital, Nagoya; Department of Rheumatology, Tokyo Koseinenkin Hospital, Tokyo; Ito Orthopedic Clinic, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota; Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Shizuoka; Department of Orthopedic Surgery, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan, Japan.H. Matsubara, MD; T. Kojima, MD; N. Takahashi, MD; K. Funahashi, MD; D. Kato, MD; M. Hanabayashi, MD; K. Terabe, MD; N. Ishiguro, MD, Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; A. Kaneko, MD; H. Ishikawa, MD; Y. Hattori, MD, Department of Orthopedic Surgery, Nagoya Medical Center; Y. Hirano, MD, Department of Rheumatology, Toyohashi Municipal Hospital; H. Miyake, MD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Oguchi, MD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Takagi, MD, Department of Orthopedic Surgery, Nagoya Central Hospital; Y. Yabe, MD, Department of Rheumatology, Tokyo Koseinenkin Hospital; T. Kato, MD, Kato Orthopedic Clinic; T. Ito, MD, Ito Orthopedic Clinic; N. Fukaya, MD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; Y. Kanayama, MD, Department of Orthopedic Surgery, Toyota Kosei Hospital; T. Shioura, MD, Department of Orthopedic Surgery, Shizuoka Kosei Hospital; M. Hayashi, MD, Department of Orthopedic Surgery, Nagano Red Cross Hospital; T. Fujibayashi, MD, Dep
authors.forename: Tomone
authors.initials: T
authors.lastname: Shioura
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; Department of Orthopedic Surgery, Nagoya Medical Center; Department of Orthopedic Surgery, Nagoya Central Hospital, Nagoya; Department of Rheumatology, Tokyo Koseinenkin Hospital, Tokyo; Ito Orthopedic Clinic, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota; Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Shizuoka; Department of Orthopedic Surgery, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan, Japan.H. Matsubara, MD; T. Kojima, MD; N. Takahashi, MD; K. Funahashi, MD; D. Kato, MD; M. Hanabayashi, MD; K. Terabe, MD; N. Ishiguro, MD, Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; A. Kaneko, MD; H. Ishikawa, MD; Y. Hattori, MD, Department of Orthopedic Surgery, Nagoya Medical Center; Y. Hirano, MD, Department of Rheumatology, Toyohashi Municipal Hospital; H. Miyake, MD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Oguchi, MD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Takagi, MD, Department of Orthopedic Surgery, Nagoya Central Hospital; Y. Yabe, MD, Department of Rheumatology, Tokyo Koseinenkin Hospital; T. Kato, MD, Kato Orthopedic Clinic; T. Ito, MD, Ito Orthopedic Clinic; N. Fukaya, MD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; Y. Kanayama, MD, Department of Orthopedic Surgery, Toyota Kosei Hospital; T. Shioura, MD, Department of Orthopedic Surgery, Shizuoka Kosei Hospital; M. Hayashi, MD, Department of Orthopedic Surgery, Nagano Red Cross Hospital; T. Fujibayashi, MD, Dep
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Hayashi
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; Department of Orthopedic Surgery, Nagoya Medical Center; Department of Orthopedic Surgery, Nagoya Central Hospital, Nagoya; Department of Rheumatology, Tokyo Koseinenkin Hospital, Tokyo; Ito Orthopedic Clinic, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota; Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Shizuoka; Department of Orthopedic Surgery, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan, Japan.H. Matsubara, MD; T. Kojima, MD; N. Takahashi, MD; K. Funahashi, MD; D. Kato, MD; M. Hanabayashi, MD; K. Terabe, MD; N. Ishiguro, MD, Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; A. Kaneko, MD; H. Ishikawa, MD; Y. Hattori, MD, Department of Orthopedic Surgery, Nagoya Medical Center; Y. Hirano, MD, Department of Rheumatology, Toyohashi Municipal Hospital; H. Miyake, MD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Oguchi, MD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Takagi, MD, Department of Orthopedic Surgery, Nagoya Central Hospital; Y. Yabe, MD, Department of Rheumatology, Tokyo Koseinenkin Hospital; T. Kato, MD, Kato Orthopedic Clinic; T. Ito, MD, Ito Orthopedic Clinic; N. Fukaya, MD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; Y. Kanayama, MD, Department of Orthopedic Surgery, Toyota Kosei Hospital; T. Shioura, MD, Department of Orthopedic Surgery, Shizuoka Kosei Hospital; M. Hayashi, MD, Department of Orthopedic Surgery, Nagano Red Cross Hospital; T. Fujibayashi, MD, Dep
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Fujibayashi
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; Department of Orthopedic Surgery, Nagoya Medical Center; Department of Orthopedic Surgery, Nagoya Central Hospital, Nagoya; Department of Rheumatology, Tokyo Koseinenkin Hospital, Tokyo; Ito Orthopedic Clinic, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota; Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Shizuoka; Department of Orthopedic Surgery, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan, Japan.H. Matsubara, MD; T. Kojima, MD; N. Takahashi, MD; K. Funahashi, MD; D. Kato, MD; M. Hanabayashi, MD; K. Terabe, MD; N. Ishiguro, MD, Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; A. Kaneko, MD; H. Ishikawa, MD; Y. Hattori, MD, Department of Orthopedic Surgery, Nagoya Medical Center; Y. Hirano, MD, Department of Rheumatology, Toyohashi Municipal Hospital; H. Miyake, MD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Oguchi, MD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Takagi, MD, Department of Orthopedic Surgery, Nagoya Central Hospital; Y. Yabe, MD, Department of Rheumatology, Tokyo Koseinenkin Hospital; T. Kato, MD, Kato Orthopedic Clinic; T. Ito, MD, Ito Orthopedic Clinic; N. Fukaya, MD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; Y. Kanayama, MD, Department of Orthopedic Surgery, Toyota Kosei Hospital; T. Shioura, MD, Department of Orthopedic Surgery, Shizuoka Kosei Hospital; M. Hayashi, MD, Department of Orthopedic Surgery, Nagano Red Cross Hospital; T. Fujibayashi, MD, Dep
authors.forename: Nobunori
authors.initials: N
authors.lastname: Takahashi
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; Department of Orthopedic Surgery, Nagoya Medical Center; Department of Orthopedic Surgery, Nagoya Central Hospital, Nagoya; Department of Rheumatology, Tokyo Koseinenkin Hospital, Tokyo; Ito Orthopedic Clinic, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota; Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Shizuoka; Department of Orthopedic Surgery, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan, Japan.H. Matsubara, MD; T. Kojima, MD; N. Takahashi, MD; K. Funahashi, MD; D. Kato, MD; M. Hanabayashi, MD; K. Terabe, MD; N. Ishiguro, MD, Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; A. Kaneko, MD; H. Ishikawa, MD; Y. Hattori, MD, Department of Orthopedic Surgery, Nagoya Medical Center; Y. Hirano, MD, Department of Rheumatology, Toyohashi Municipal Hospital; H. Miyake, MD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Oguchi, MD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Takagi, MD, Department of Orthopedic Surgery, Nagoya Central Hospital; Y. Yabe, MD, Department of Rheumatology, Tokyo Koseinenkin Hospital; T. Kato, MD, Kato Orthopedic Clinic; T. Ito, MD, Ito Orthopedic Clinic; N. Fukaya, MD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; Y. Kanayama, MD, Department of Orthopedic Surgery, Toyota Kosei Hospital; T. Shioura, MD, Department of Orthopedic Surgery, Shizuoka Kosei Hospital; M. Hayashi, MD, Department of Orthopedic Surgery, Nagano Red Cross Hospital; T. Fujibayashi, MD, Dep
authors.forename: Koji
authors.initials: K
authors.lastname: Funahashi
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; Department of Orthopedic Surgery, Nagoya Medical Center; Department of Orthopedic Surgery, Nagoya Central Hospital, Nagoya; Department of Rheumatology, Tokyo Koseinenkin Hospital, Tokyo; Ito Orthopedic Clinic, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota; Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Shizuoka; Department of Orthopedic Surgery, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan, Japan.H. Matsubara, MD; T. Kojima, MD; N. Takahashi, MD; K. Funahashi, MD; D. Kato, MD; M. Hanabayashi, MD; K. Terabe, MD; N. Ishiguro, MD, Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; A. Kaneko, MD; H. Ishikawa, MD; Y. Hattori, MD, Department of Orthopedic Surgery, Nagoya Medical Center; Y. Hirano, MD, Department of Rheumatology, Toyohashi Municipal Hospital; H. Miyake, MD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Oguchi, MD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Takagi, MD, Department of Orthopedic Surgery, Nagoya Central Hospital; Y. Yabe, MD, Department of Rheumatology, Tokyo Koseinenkin Hospital; T. Kato, MD, Kato Orthopedic Clinic; T. Ito, MD, Ito Orthopedic Clinic; N. Fukaya, MD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; Y. Kanayama, MD, Department of Orthopedic Surgery, Toyota Kosei Hospital; T. Shioura, MD, Department of Orthopedic Surgery, Shizuoka Kosei Hospital; M. Hayashi, MD, Department of Orthopedic Surgery, Nagano Red Cross Hospital; T. Fujibayashi, MD, Dep
authors.forename: Daizo
authors.initials: D
authors.lastname: Kato
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; Department of Orthopedic Surgery, Nagoya Medical Center; Department of Orthopedic Surgery, Nagoya Central Hospital, Nagoya; Department of Rheumatology, Tokyo Koseinenkin Hospital, Tokyo; Ito Orthopedic Clinic, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota; Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Shizuoka; Department of Orthopedic Surgery, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan, Japan.H. Matsubara, MD; T. Kojima, MD; N. Takahashi, MD; K. Funahashi, MD; D. Kato, MD; M. Hanabayashi, MD; K. Terabe, MD; N. Ishiguro, MD, Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; A. Kaneko, MD; H. Ishikawa, MD; Y. Hattori, MD, Department of Orthopedic Surgery, Nagoya Medical Center; Y. Hirano, MD, Department of Rheumatology, Toyohashi Municipal Hospital; H. Miyake, MD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Oguchi, MD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Takagi, MD, Department of Orthopedic Surgery, Nagoya Central Hospital; Y. Yabe, MD, Department of Rheumatology, Tokyo Koseinenkin Hospital; T. Kato, MD, Kato Orthopedic Clinic; T. Ito, MD, Ito Orthopedic Clinic; N. Fukaya, MD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; Y. Kanayama, MD, Department of Orthopedic Surgery, Toyota Kosei Hospital; T. Shioura, MD, Department of Orthopedic Surgery, Shizuoka Kosei Hospital; M. Hayashi, MD, Department of Orthopedic Surgery, Nagano Red Cross Hospital; T. Fujibayashi, MD, Dep
authors.forename: Masahiro
authors.initials: M
authors.lastname: Hanabayashi
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; Department of Orthopedic Surgery, Nagoya Medical Center; Department of Orthopedic Surgery, Nagoya Central Hospital, Nagoya; Department of Rheumatology, Tokyo Koseinenkin Hospital, Tokyo; Ito Orthopedic Clinic, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota; Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Shizuoka; Department of Orthopedic Surgery, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan, Japan.H. Matsubara, MD; T. Kojima, MD; N. Takahashi, MD; K. Funahashi, MD; D. Kato, MD; M. Hanabayashi, MD; K. Terabe, MD; N. Ishiguro, MD, Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; A. Kaneko, MD; H. Ishikawa, MD; Y. Hattori, MD, Department of Orthopedic Surgery, Nagoya Medical Center; Y. Hirano, MD, Department of Rheumatology, Toyohashi Municipal Hospital; H. Miyake, MD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Oguchi, MD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Takagi, MD, Department of Orthopedic Surgery, Nagoya Central Hospital; Y. Yabe, MD, Department of Rheumatology, Tokyo Koseinenkin Hospital; T. Kato, MD, Kato Orthopedic Clinic; T. Ito, MD, Ito Orthopedic Clinic; N. Fukaya, MD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; Y. Kanayama, MD, Department of Orthopedic Surgery, Toyota Kosei Hospital; T. Shioura, MD, Department of Orthopedic Surgery, Shizuoka Kosei Hospital; M. Hayashi, MD, Department of Orthopedic Surgery, Nagano Red Cross Hospital; T. Fujibayashi, MD, Dep
authors.forename: Kenya
authors.initials: K
authors.lastname: Terabe
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; Department of Orthopedic Surgery, Nagoya Medical Center; Department of Orthopedic Surgery, Nagoya Central Hospital, Nagoya; Department of Rheumatology, Tokyo Koseinenkin Hospital, Tokyo; Ito Orthopedic Clinic, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota; Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Shizuoka; Department of Orthopedic Surgery, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan, Japan.H. Matsubara, MD; T. Kojima, MD; N. Takahashi, MD; K. Funahashi, MD; D. Kato, MD; M. Hanabayashi, MD; K. Terabe, MD; N. Ishiguro, MD, Department of Orthopedic Surgery and Rheumatology, Nagoya University, School of Medicine; A. Kaneko, MD; H. Ishikawa, MD; Y. Hattori, MD, Department of Orthopedic Surgery, Nagoya Medical Center; Y. Hirano, MD, Department of Rheumatology, Toyohashi Municipal Hospital; H. Miyake, MD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Oguchi, MD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Takagi, MD, Department of Orthopedic Surgery, Nagoya Central Hospital; Y. Yabe, MD, Department of Rheumatology, Tokyo Koseinenkin Hospital; T. Kato, MD, Kato Orthopedic Clinic; T. Ito, MD, Ito Orthopedic Clinic; N. Fukaya, MD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; Y. Kanayama, MD, Department of Orthopedic Surgery, Toyota Kosei Hospital; T. Shioura, MD, Department of Orthopedic Surgery, Shizuoka Kosei Hospital; M. Hayashi, MD, Department of Orthopedic Surgery, Nagano Red Cross Hospital; T. Fujibayashi, MD, Dep
authors.forename: Naoki
authors.initials: N
authors.lastname: Ishiguro
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D018501:Antirheumatic Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000453:epidemiology; D004359:Drug Therapy, Combination; D000068800:Etanercept; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000009:adverse effects* / Q000627:therapeutic use*; D007564:Japan / Q000453:epidemiology; D053208:Kaplan-Meier Estimate; D008137:Longitudinal Studies; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D016016:Proportional Hazards Models; D018124:Receptors, Tumor Necrosis Factor / Q000627:therapeutic use*; D012189:Retrospective Studies; D012307:Risk Factors; D017211:Treatment Failure; D016896:Treatment Outcome; D028761:Withholding Treatment
chemical_list: D018501:Antirheumatic Agents; D007074:Immunoglobulin G; D018124:Receptors, Tumor Necrosis Factor; D000068800:Etanercept; D008727:Methotrexate
keywords: AGE; ETANERCEPT; METHOTREXATE; RETENTION; RHEUMATOID ARTHRITIS