title: Risk of gastric cancer is associated with PRKAA1 gene polymorphisms in Koreans.
abstract: OBJECTIVE
  To evaluate the association between genetic polymorphisms of the gene encoding AMP-activated protein kinase (PRKAA1) and the risk of gastric cancer.
  
  
  METHODS
  The study subjects consisted of 477 age- and sex-matched case-control pairs. Genotyping was performed for 5 tag single nucleotide polymorphisms (SNPs): rs13361707, rs154268, rs3805486, rs6882903, and rs10074991. Associations between gastric cancer and putative risk factors (including the SNPs) were analyzed with multivariate conditional logistic regression models, after adjusting for potential confounding factors. Multiple testing corrections were implemented following methodology for controlling the false discovery rate. Gene-based association tests were performed by using the versatile gene-based association study (VEGAS) method.
  
  
  RESULTS
  In the dominant model, SNPs rs13361707 [odds ratio (OR) = 1.51, 95%CI: 1.07-2.11)], rs154268 (OR = 1.65, 95%CI: 1.22-2.22), rs6882903 (OR = 1.48, 95%CI: 1.09-2.00), and rs10074991 (OR = 1.53, 95%CI: 1.09-2.16) were significantly associated with an increased risk of gastric cancer. In the recessive model, SNPs rs154268 (OR = 1.66, 95%CI: 1.22-2.26), rs3805486 (OR = 0.63, 95%CI: 0.46-0.85), and rs10074991 (OR = 1.47, 95%CI: 1.15-1.88) were significant risk or protective factors for gastric cancer. In the codominant model, the ORs of each of the 5 SNPs were statistically significant. All SNPs in the model showed a dose-response relationship between the minor allele frequency and the risk of gastric cancer. Most notably, subjects with a homozygous minor allele in SNP rs10074991 showed 2.15 times the risk of gastric cancer as subjects without a minor allele. The PRKAA1 gene showed a significant gene-based association with gastric cancer in the VEGAS test.
  
  
  CONCLUSIONS
  All 5 tested tag SNPs of the PRKAA1 gene (rs13361707, rs154268, rs3805486, rs6882903, and rs10074991) were significantly associated with gastric cancer.
authors.affiliation: Yong-Dae Kim, Dong-Hyuk Yim, Sang-Yong Eom, Sun In Moon, Heon Kim, Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju 361-763, South Korea.
authors.forename: Yong-Dae
authors.initials: YD
authors.lastname: Kim
authors.affiliation: Yong-Dae Kim, Dong-Hyuk Yim, Sang-Yong Eom, Sun In Moon, Heon Kim, Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju 361-763, South Korea.
authors.forename: Dong-Hyuk
authors.initials: DH
authors.lastname: Yim
authors.affiliation: Yong-Dae Kim, Dong-Hyuk Yim, Sang-Yong Eom, Sun In Moon, Heon Kim, Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju 361-763, South Korea.
authors.forename: Sang-Yong
authors.initials: SY
authors.lastname: Eom
authors.affiliation: Yong-Dae Kim, Dong-Hyuk Yim, Sang-Yong Eom, Sun In Moon, Heon Kim, Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju 361-763, South Korea.
authors.forename: Sun In
authors.initials: SI
authors.lastname: Moon
authors.affiliation: Yong-Dae Kim, Dong-Hyuk Yim, Sang-Yong Eom, Sun In Moon, Heon Kim, Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju 361-763, South Korea.
authors.forename: Hyo-Yung
authors.initials: HY
authors.lastname: Yun
authors.affiliation: Yong-Dae Kim, Dong-Hyuk Yim, Sang-Yong Eom, Sun In Moon, Heon Kim, Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju 361-763, South Korea.
authors.forename: Young-Jin
authors.initials: YJ
authors.lastname: Song
authors.affiliation: Yong-Dae Kim, Dong-Hyuk Yim, Sang-Yong Eom, Sun In Moon, Heon Kim, Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju 361-763, South Korea.
authors.forename: Sei-Jin
authors.initials: SJ
authors.lastname: Youn
authors.affiliation: Yong-Dae Kim, Dong-Hyuk Yim, Sang-Yong Eom, Sun In Moon, Heon Kim, Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju 361-763, South Korea.
authors.forename: Taisun
authors.initials: T
authors.lastname: Hyun
authors.affiliation: Yong-Dae Kim, Dong-Hyuk Yim, Sang-Yong Eom, Sun In Moon, Heon Kim, Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju 361-763, South Korea.
authors.forename: Joo-Seung
authors.initials: JS
authors.lastname: Park
authors.affiliation: Yong-Dae Kim, Dong-Hyuk Yim, Sang-Yong Eom, Sun In Moon, Heon Kim, Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju 361-763, South Korea.
authors.forename: Byung Sik
authors.initials: BS
authors.lastname: Kim
authors.affiliation: Yong-Dae Kim, Dong-Hyuk Yim, Sang-Yong Eom, Sun In Moon, Heon Kim, Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju 361-763, South Korea.
authors.forename: Jong-Young
authors.initials: JY
authors.lastname: Lee
authors.affiliation: Yong-Dae Kim, Dong-Hyuk Yim, Sang-Yong Eom, Sun In Moon, Heon Kim, Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju 361-763, South Korea.
authors.forename: Hee Kwan
authors.initials: HK
authors.lastname: Won
authors.affiliation: Yong-Dae Kim, Dong-Hyuk Yim, Sang-Yong Eom, Sun In Moon, Heon Kim, Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju 361-763, South Korea.
authors.forename: Heon
authors.initials: H
authors.lastname: Kim
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000235:genetics*; D000368:Aged; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D056910:Republic of Korea / Q000453:epidemiology; D018570:Risk Assessment; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*
chemical_list: D055372:AMP-Activated Protein Kinases; C526180:PRKAA1 protein, human
keywords: AMP-activated protein kinase; Case-control study; Gastric cancer; PRKAA1; Single nucleotide polymorphism