title: cCMP is a substrate for MRP5.
abstract: The cyclic pyrimidine nucleotide cCMP has been suggested to serve as second messenger. However, phosphodiesterases studied so far do not hydrolyze cCMP. Therefore, we searched for alternative cCMP inactivation mechanisms. cCMP is a substrate for multidrug resistance protein 5, indicating that export from the cytosol into the extracellular space is an important inactivation mechanism for cCMP.
authors.affiliation: Institute of Pharmacology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
authors.forename: Svenja
authors.initials: S
authors.lastname: Laue
authors.forename: Moritz
authors.initials: M
authors.lastname: Winterhoff
authors.forename: Volkhard
authors.initials: V
authors.lastname: Kaever
authors.forename: Jeroen J
authors.initials: JJ
authors.lastname: van den Heuvel
authors.forename: Frans G
authors.initials: FG
authors.lastname: Russel
authors.forename: Roland
authors.initials: R
authors.lastname: Seifert
mesh_terms: D001692:Biological Transport; D057809:HEK293 Cells; D006801:Humans; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000378:metabolism*; D009712:Nucleotides, Cyclic / Q000378:metabolism*
chemical_list: D027425:ATP-Binding Cassette, Sub-Family C Proteins; D009712:Nucleotides, Cyclic