title: Circulating levels of sirtuin 4, a potential marker of oxidative metabolism, related to coronary artery disease in obese patients suffering from NAFLD, with normal or slightly increased liver enzymes.
abstract: The present study shows low circulating levels of SIRT4 in obese patients with nonalcoholic fatty liver disease mirroring its reduced mitochondrial expression in an attempt to increase the fat oxidative capacity and then the mitochondrial function in liver and in muscle. SIRT4 modulates the metabolism of free fatty acids reducing their high circulating levels but, unfortunately, increasing ROS production. Great concentration of free fatty acids, released by adipose tissue, coupled with oxidative stress, directly results in endothelial dysfunction, early atherosclerosis, and coronary artery disease risk factor.
authors.affiliation: Department of Clinical Medicine and Surgery, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy ; Centro Ricerche Oncologiche di Mercogliano, Istituto Nazionale Per Lo Studio E La Cura Dei Tumori "Fondazione Giovanni Pascale", IRCCS, 83013 Mercogliano, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Tarantino
authors.affiliation: Center of Obesity and Eating Disorders, Stella Maris Mediterraneum Foundation, C/da Santa Lucia, Chiaromonte, 80035 Potenza, Italy.
authors.forename: Carmine
authors.identifier: 0000-0003-2886-8349
authors.initials: C
authors.lastname: Finelli
authors.affiliation: Department of Biochemistry and Medical Biotechnology, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Scopacasa
authors.affiliation: Department of Clinical Medicine and Surgery, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Pasanisi
authors.affiliation: Department of Clinical Medicine and Surgery, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Contaldo
authors.affiliation: Department of Neuroscience, Unit of Clinical Pharmacology, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Capone
authors.affiliation: Department of Clinical Medicine and Surgery, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Savastano
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood* / Q000150:complications / Q000378:metabolism; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D008099:Liver / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D024101:Mitochondrial Proteins / Q000097:blood*; D015999:Multivariate Analysis; D018482:Muscle, Skeletal / Q000473:pathology; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood* / Q000150:complications / Q000378:metabolism; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000378:metabolism; D010084:Oxidation-Reduction; D037761:Sirtuins / Q000097:blood*
chemical_list: D015415:Biomarkers; D024101:Mitochondrial Proteins; C525357:SIRT4 protein, human; D037761:Sirtuins