title: Pseudaboydins A and B: novel isobenzofuranone derivatives from marine fungus Pseudallescheria boydii associated with starfish Acanthaster planci.
abstract: Two novel isobenzofuranone derivatives, pseudaboydins A (1) and B (2), along with five known compounds, including (R)-2-(2-hydroxypropan-2-yl)-2,3-dihydro-5-hydroxybenzofuran (3), (R)-2-(2-hydroxypropan-2-yl)-2,3-dihydro-5-methoxybenzofuran (4), 3,3'-dihydroxy-5,5'-dimethyldiphenyl ether (5), 3-(3-methoxy-5-methylphenoxy)-5-methylphenol (6) and (-)-regiolone (7), were isolated from the culture broth of the marine fungus, Pseudallescheria boydii, associated with the starfish, Acanthaster planci. Their structures were elucidated primarily based on NMR and MS data. The absolute configurations of 1-4 were determined by CD spectroscopy and single-crystal X-ray diffraction studies. The cytotoxic and antibacterial activities of 1-4 were evaluated. Pseudaboydin A (1) showed moderate cytotoxic activity against human nasopharyngeal carcinoma cell line HONE1, human nasopharyngeal carcinoma cell line SUNE1 and human glandular lung cancer cell line GLC82 with IC50 values of 37.1, 46.5 and 87.2 μM, respectively.
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. natprodlwl@gmail.com.
authors.forename: Wen-Jian
authors.initials: WJ
authors.lastname: Lan
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. natprodlwl@gmail.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. natprodlwl@gmail.com.
authors.forename: Wan-Ling
authors.initials: WL
authors.lastname: Liang
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China. marinezengx@gmail.com.
authors.forename: Zeng
authors.initials: Z
authors.lastname: Xu
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. lexiu2012@163.com.
authors.forename: Xiu
authors.initials: X
authors.lastname: Le
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. junxu@biochemomes.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China. cklam@mail.sysu.edu.cn.
authors.forename: Chi-Keung
authors.initials: CK
authors.lastname: Lam
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. lssydp@mail.sysu.edu.cn.
authors.forename: De-Po
authors.initials: DP
authors.lastname: Yang
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China. ceslhj@mail.sysu.edu.cn.
authors.forename: Hou-Jin
authors.initials: HJ
authors.lastname: Li
authors.affiliation: Institute of Chinese Medical Sciences, Guangdong Pharmaceutical University, Guangzhou 510006, China. wanglaiyou@gdpu.edu.cn.
authors.forename: Lai-You
authors.initials: LY
authors.lastname: Wang
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D009682:Magnetic Resonance Spectroscopy; D011541:Pseudallescheria / Q000378:metabolism*; D013215:Starfish / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D001572:Benzofurans; C000601943:pseudaboydin A