title: A concise synthesis of benzimidazoles via the microwave-assisted one-pot batch reaction of amino acids up to a 10-g scale.
abstract: An efficient method for the synthesis of aminomethyl benzimidazoles is developed by using a one-pot batch reaction between amino acids and o-phenylenediamines. This reaction proceeds smoothly in an unmodified household microwave oven, even though scale-up is to 10 g. A desirable method for the quick synthesis of benzimidazoles, which are used as a kind of important intermediates in drug synthesis, is provided by the scale-up utilization of amino acid resource.
authors.affiliation: Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, School of Chemistry and Environment, South China Normal University, Guangzhou, 510006, People's Republic of China.
authors.forename: Pai
authors.initials: P
authors.lastname: Peng
authors.forename: Jin-Feng
authors.initials: JF
authors.lastname: Xiong
authors.forename: Guang-Zhen
authors.initials: GZ
authors.lastname: Mo
authors.forename: Jia-Li
authors.initials: JL
authors.lastname: Zheng
authors.forename: Ren-Hong
authors.initials: RH
authors.lastname: Chen
authors.forename: Xiao-Yun
authors.initials: XY
authors.lastname: Chen
authors.forename: Zhao-Yang
authors.initials: ZY
authors.lastname: Wang
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D007202:Indicators and Reagents; D008872:Microwaves; D015394:Molecular Structure; D010655:Phenylenediamines / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D001562:Benzimidazoles; D007202:Indicators and Reagents; D010655:Phenylenediamines