title: Cutaneous lesions of Kikuchi's disease: evolution of histopathological findings.
abstract: We report a 38-year-old male patient who presented with cutaneous lesions mimicking widespread discoid lupus erythematosus with high-grade fever, arthralgia and lymphadenopathy. Additional lymph node and skin biopsies, however, revealed karyorrhectic debris without neutrophils and numerous CD68-positive cells, a characteristic finding of Kikuchi's disease (KD). Comparing skin biopsies on different occasions, we could see different forms of histopathology. The histopathology of skin lesions of KD may vary during the clinical course, which may reflect the stage of the disease.
authors.affiliation: Department of Dermatology, Asahikawa Medical University, Asahikawa, Japan.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Kanno
authors.forename: Masako
authors.initials: M
authors.lastname: Minami-Hori
authors.forename: Akemi
authors.initials: A
authors.lastname: Ishida-Yamamoto
authors.forename: Keiji
authors.initials: K
authors.lastname: Komura
authors.forename: Kensuke
authors.initials: K
authors.lastname: Oikawa
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Miyokawa
authors.forename: Hajime
authors.initials: H
authors.lastname: Iizuka
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D003937:Diagnosis, Differential; D020042:Histiocytic Necrotizing Lymphadenitis / Q000175:diagnosis / Q000276:immunology / Q000473:pathology*; D006801:Humans; D008179:Lupus Erythematosus, Discoid / Q000175:diagnosis; D008297:Male; D012867:Skin / Q000276:immunology / Q000473:pathology; D012871:Skin Diseases / Q000175:diagnosis / Q000276:immunology / Q000473:pathology*; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; C067980:CD68 antigen, human; D000097382:CD68 Molecule
keywords: CD68; Kikuchi's disease; apoptotic keratinocytes; nuclear debris; systemic lupus erythematosus