title: [Fructose transporter in yeasts].
abstract: Study of hexoses transporter started with discovery of galactose permease in Saccharomyces cerevisiae. Glucose, fructose and mannose assimilation is assumed by numerous proteins encoded by different genes. To date over 20 hexoses transporters, belonging to Sugar Porter family and to Major Facilitator Superfamily, were known. Genome sequence analysis of Candida glabrata, Kluyveromyces lactis, Yarrowia lipolytica, S. cerevisaie and Debaryomyces hansenii reveled potential presence of 17-48 sugar porter proteins. Glucose transporters in S. cerevisiae have been already characterized. In this paper, hexoses transporters, responsible for assimilation of fructose by cells, are presented and compared. Fructose specific transporter are described for yeasts: Zygosaccharomyces rouxii, Zygosaccharomyces bailli, K. lactis, Saccharomyces pastorianus, S. cerevisiae winemaking strain and for fungus Botritys cinerea and human (Glut5p). Among six yeasts transporters, five are fructose specific, acting by facilitated diffusion or proton symport. Yeasts monosaccharides transporter studies allow understanding of sugars uptake and metabolism important aspects, even in higher eukaryotes cells.
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Lazar
authors.forename: Adam
authors.initials: A
authors.lastname: Dobrowolski
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Robak
mesh_terms: D001692:Biological Transport; D002175:Candida / Q000145:classification / Q000378:metabolism; D005632:Fructose / Q000378:metabolism* / Q000493:pharmacokinetics*; D012441:Saccharomyces cerevisiae / Q000145:classification / Q000378:metabolism; D051247:Sodium-Glucose Transport Proteins / Q000378:metabolism; D013045:Species Specificity; D015003:Yeasts / Q000145:classification / Q000378:metabolism*
chemical_list: D051247:Sodium-Glucose Transport Proteins; D005632:Fructose