title: Hospital care for primary hyperparathyroidism in Italy: a 6-year register-based study.
abstract: OBJECTIVE
  Primary hyperparathyroidism (PHPT) is one of the most frequently diagnosed endocrine disorders, but few studies have focused on hospital management of the disease in Europe. We investigated the frequency of hospital admission for diagnosis and surgical treatment of PHPT in Italy.
  
  
  METHODS
  A retrospective study was conducted for investigating the hospital care for PHPT in Italy.
  
  
  METHODS
  We retrieved data from the 'Record of Hospital Discharge' of the Italian Health Ministry, from 2006 to 2011, and analyzed the codes corresponding to PHPT-related diagnoses and surgical procedures.
  
  
  RESULTS
  Overall, 46 275 hospitalization episodes for PHPT were identified during the entire period (69% in women and 31% in men; mean age 63.3±39.8 years). Patients' mean age significantly increased during the years (P<0.001). The mean length of stay was 8.2±10.5 days (28% of the episodes requiring <3 days of stay). Admissions for surgical procedures were 12 457 accounting for 26.9% of the total hospitalizations. There was a trend to a significant increase in the percentage of surgery (P<0.05). The mean hospitalization rate for PHPT was 12.9/100 000 inhabitants per year and the trend showed a significant decrease during the period of 2006-2011 (P<0.0001). The mean hospitalization rate for PHPT surgery was 3.65/100 000 per year, which significantly increased over time (P<0.001).
  
  
  CONCLUSIONS
  PHPT considerably influences the Italian Hospital healthcare system. We observed a tendency to a decrease in the frequency of hospitalization during the period of 2006-2011, most probably because of economic issues, a concomitant increased age of patients, and, interestingly, also a progressive increase in the percentage of surgical treatment among patients admitted for PHPT.
authors.affiliation: Department of Internal Medicine and Medical Disciplines'Sapienza' University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyUnit of Internal Medicine'Casa Sollievo della Sofferenza' Hospital, IRCCS, Viale dei Cappuccini snc, 71013 San Giovanni Rotondo, Foggia, ItalyFaculty of Economics (L.N.)LUSPIO University, Via delle Sette Chiese 139, 00145 Rome, ItalyMetabolic Bone Diseases UnitDivision of Endocrinology, Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, New York 10032, USA cristianac@alice.it.
authors.forename: Cristiana
authors.initials: C
authors.lastname: Cipriani
authors.affiliation: Department of Internal Medicine and Medical Disciplines'Sapienza' University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyUnit of Internal Medicine'Casa Sollievo della Sofferenza' Hospital, IRCCS, Viale dei Cappuccini snc, 71013 San Giovanni Rotondo, Foggia, ItalyFaculty of Economics (L.N.)LUSPIO University, Via delle Sette Chiese 139, 00145 Rome, ItalyMetabolic Bone Diseases UnitDivision of Endocrinology, Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, New York 10032, USA.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Carnevale
authors.affiliation: Department of Internal Medicine and Medical Disciplines'Sapienza' University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyUnit of Internal Medicine'Casa Sollievo della Sofferenza' Hospital, IRCCS, Viale dei Cappuccini snc, 71013 San Giovanni Rotondo, Foggia, ItalyFaculty of Economics (L.N.)LUSPIO University, Via delle Sette Chiese 139, 00145 Rome, ItalyMetabolic Bone Diseases UnitDivision of Endocrinology, Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, New York 10032, USA.
authors.forename: Federica
authors.initials: F
authors.lastname: Biamonte
authors.affiliation: Department of Internal Medicine and Medical Disciplines'Sapienza' University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyUnit of Internal Medicine'Casa Sollievo della Sofferenza' Hospital, IRCCS, Viale dei Cappuccini snc, 71013 San Giovanni Rotondo, Foggia, ItalyFaculty of Economics (L.N.)LUSPIO University, Via delle Sette Chiese 139, 00145 Rome, ItalyMetabolic Bone Diseases UnitDivision of Endocrinology, Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, New York 10032, USA.
authors.forename: Sara
authors.initials: S
authors.lastname: Piemonte
authors.affiliation: Department of Internal Medicine and Medical Disciplines'Sapienza' University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyUnit of Internal Medicine'Casa Sollievo della Sofferenza' Hospital, IRCCS, Viale dei Cappuccini snc, 71013 San Giovanni Rotondo, Foggia, ItalyFaculty of Economics (L.N.)LUSPIO University, Via delle Sette Chiese 139, 00145 Rome, ItalyMetabolic Bone Diseases UnitDivision of Endocrinology, Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, New York 10032, USA.
authors.forename: Jessica
authors.initials: J
authors.lastname: Pepe
authors.affiliation: Department of Internal Medicine and Medical Disciplines'Sapienza' University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyUnit of Internal Medicine'Casa Sollievo della Sofferenza' Hospital, IRCCS, Viale dei Cappuccini snc, 71013 San Giovanni Rotondo, Foggia, ItalyFaculty of Economics (L.N.)LUSPIO University, Via delle Sette Chiese 139, 00145 Rome, ItalyMetabolic Bone Diseases UnitDivision of Endocrinology, Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, New York 10032, USA.
authors.forename: Luciano
authors.initials: L
authors.lastname: Nieddu
authors.affiliation: Department of Internal Medicine and Medical Disciplines'Sapienza' University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyUnit of Internal Medicine'Casa Sollievo della Sofferenza' Hospital, IRCCS, Viale dei Cappuccini snc, 71013 San Giovanni Rotondo, Foggia, ItalyFaculty of Economics (L.N.)LUSPIO University, Via delle Sette Chiese 139, 00145 Rome, ItalyMetabolic Bone Diseases UnitDivision of Endocrinology, Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, New York 10032, USA.
authors.forename: John P
authors.initials: JP
authors.lastname: Bilezikian
authors.affiliation: Department of Internal Medicine and Medical Disciplines'Sapienza' University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyUnit of Internal Medicine'Casa Sollievo della Sofferenza' Hospital, IRCCS, Viale dei Cappuccini snc, 71013 San Giovanni Rotondo, Foggia, ItalyFaculty of Economics (L.N.)LUSPIO University, Via delle Sette Chiese 139, 00145 Rome, ItalyMetabolic Bone Diseases UnitDivision of Endocrinology, Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, New York 10032, USA.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Minisola
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D001847:Bone Diseases / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data / Q000639:trends; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000150:complications / Q000453:epidemiology* / Q000601:surgery*; D007558:Italy / Q000453:epidemiology; D007669:Kidney Calculi / Q000453:epidemiology* / Q000209:etiology; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D010351:Patient Discharge; D015995:Prevalence; D012042:Registries; D012189:Retrospective Studies; D012744:Sex Ratio; D013514:Surgical Procedures, Operative / Q000706:statistics & numerical data