title: Uric acid and gamma-glutamyl transferase activity are associated with left ventricular remodeling indices in patients with chronic heart failure.
abstract: OBJECTIVE
  Uric acid and gamma-glutamyl transferase are prognostic indicators in chronic heart failure. Nevertheless, the mechanism underlying the association between uric acid, gamma-glutamyl transferase, and chronic heart failure progression and prognosis remains largely unknown.
  
  
  METHODS
  The association of uric acid and gamma-glutamyl transferase with flow-mediated dilation and echocardiographic indices of cardiac remodeling was addressed in 120 patients with chronic ischemic heart failure. To determine the independent contribution of uric acid and gamma-glutamyl transferase to the flow-mediated dilation and echocardiographic indices of remodeling, a series of multiple linear regression models, based on traditional and nontraditional risk factors impacting upon these parameters, were constructed.
  
  
  RESULTS
  Uric acid, but not gamma-glutamyl transferase, was an independent predictor of flow-mediated dilation. Uric acid was associated with all the echocardiographic indices of left ventricular dysfunction tested in 3 multiple-regression models. Uric acid correlated with left ventricular end-systolic diameter, left ventricular end-diastolic diameter, left ventricular end-systolic volume, and left ventricular end-diastolic volume (r = 0.337; r = 0.340; r = 0.321; r = 0.294; P = .001, respectively). Gamma-glutamyl transferase was an independent predictor of left ventricular end-systolic volume and left ventricular end-diastolic volume, after adjustment for all variables. Gamma-glutamyl transferase correlated with left ventricular end-systolic diameter, left ventricular end-diastolic diameter, left ventricular end-systolic volume, and left ventricular end-diastolic volume (r = 0.238, P = .009; r = 0.219, P = .016; r = 0.359, P < .001; r = 0.369, P = .001, respectively).
  
  
  CONCLUSIONS
  Serum uric acid and gamma-glutamyl transferase levels are associated with left ventricular remodeling in patients with chronic ischemic heart failure.
authors.affiliation: Odeljenje Kardiologije, Klinicko-Bolnicki Centar Bezanijska Kosa, Belgrade, Serbia.
authors.forename: Slavica
authors.initials: S
authors.lastname: Radovanovic
authors.affiliation: Institut za Medicinsku i Klinicku Biohemiju, Medicinski Fakultet, Univerzitet u Beogradu, Belgrade, Serbia.
authors.forename: Ana
authors.initials: A
authors.lastname: Savic-Radojevic
authors.affiliation: Institut za Epidemiologiju, Medicinski Fakultet, Univerzitet u Beogradu, Belgrade, Serbia.
authors.forename: Tatjana
authors.initials: T
authors.lastname: Pekmezovic
authors.affiliation: Odeljenje Kardiologije, Klinicko-Bolnicki Centar Bezanijska Kosa, Belgrade, Serbia; Medicinski Fakultet, Univerzitet u Beogradu, Belgrade, Serbia.
authors.forename: Olivera
authors.initials: O
authors.lastname: Markovic
authors.affiliation: Odeljenje Kardiologije, Klinicko-Bolnicki Centar Bezanijska Kosa, Belgrade, Serbia.
authors.forename: Lidija
authors.initials: L
authors.lastname: Memon
authors.affiliation: Odeljenje Kardiologije, Klinicko-Bolnicki Centar Bezanijska Kosa, Belgrade, Serbia; Medicinski Fakultet, Univerzitet u Beogradu, Belgrade, Serbia.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Jelic
authors.affiliation: Medicinski Fakultet, Univerzitet u Beogradu, Belgrade, Serbia; Klinika za Kardiovaskularne Bolesti, Klinicki Centar Srbije, Belgrade, Serbia.
authors.forename: Dragan
authors.initials: D
authors.lastname: Simic
authors.affiliation: Institut za Medicinsku i Klinicku Biohemiju, Medicinski Fakultet, Univerzitet u Beogradu, Belgrade, Serbia.
authors.forename: Tanja
authors.initials: T
authors.lastname: Radic
authors.affiliation: Institut za Medicinsku i Klinicku Biohemiju, Medicinski Fakultet, Univerzitet u Beogradu, Belgrade, Serbia.
authors.forename: Marija
authors.initials: M
authors.lastname: Pljesa-Ercegovac
authors.affiliation: Institut za Medicinsku i Klinicku Biohemiju, Medicinski Fakultet, Univerzitet u Beogradu, Belgrade, Serbia. Electronic address: tatjanasimic@med.bg.ac.rs.
authors.forename: Tatjana
authors.initials: T
authors.lastname: Simic
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D018450:Disease Progression; D004452:Echocardiography; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013318:Stroke Volume / Q000502:physiology; D014527:Uric Acid / Q000097:blood*; D016277:Ventricular Function, Left / Q000502:physiology*; D020257:Ventricular Remodeling; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D015415:Biomarkers; D014527:Uric Acid; D005723:gamma-Glutamyltransferase
keywords: Chronic heart failure; Dilatación mediada por flujo; Estrés oxidativo; Flow mediated dilation; Gamma-glutamyl transferase; Gammaglutamil transferasa; Insuficiencia cardiaca crónica; Oxidative stress; Remodelado; Remodeling; Uric acid; Ácido úrico