title: Tubulopapillary adenoma of the gallbladder accompanied by bile duct tumor thrombus.
abstract: Intraductal papillary mucinous neoplasm of the bile duct (IPNB) is recognized as a precancerous lesion; however, both its pathogenesis and progression remain unclear. We present here a case of IPNB arising from the gallbladder accompanied by bile duct tumor thrombus in a 79-year-old female. The resected specimen revealed a tubulopapillary adenoma with no malignant cells. This case suggests that even in the absence of malignant cells, these tumors can behave as malignant tumors requiring aggressive treatment. Even if no malignant cells are present, intraepithelial neoplasms occurring in the ampullopancreatobiliary tract can behave as malignant tumors.
authors.affiliation: Kentaroh Yamamoto, Fumio Yamamoto, Hirotsune Igimi, Mami Yamamoto, Department of Surgery, Yamamoto Memorial Hospital, Saga 848-0031, Japan.
authors.forename: Kentaroh
authors.initials: K
authors.lastname: Yamamoto
authors.affiliation: Kentaroh Yamamoto, Fumio Yamamoto, Hirotsune Igimi, Mami Yamamoto, Department of Surgery, Yamamoto Memorial Hospital, Saga 848-0031, Japan.
authors.forename: Fumio
authors.initials: F
authors.lastname: Yamamoto
authors.affiliation: Kentaroh Yamamoto, Fumio Yamamoto, Hirotsune Igimi, Mami Yamamoto, Department of Surgery, Yamamoto Memorial Hospital, Saga 848-0031, Japan.
authors.forename: Atsuhiro
authors.initials: A
authors.lastname: Maeda
authors.affiliation: Kentaroh Yamamoto, Fumio Yamamoto, Hirotsune Igimi, Mami Yamamoto, Department of Surgery, Yamamoto Memorial Hospital, Saga 848-0031, Japan.
authors.forename: Hirotsune
authors.initials: H
authors.lastname: Igimi
authors.affiliation: Kentaroh Yamamoto, Fumio Yamamoto, Hirotsune Igimi, Mami Yamamoto, Department of Surgery, Yamamoto Memorial Hospital, Saga 848-0031, Japan.
authors.forename: Mami
authors.initials: M
authors.lastname: Yamamoto
authors.affiliation: Kentaroh Yamamoto, Fumio Yamamoto, Hirotsune Igimi, Mami Yamamoto, Department of Surgery, Yamamoto Memorial Hospital, Saga 848-0031, Japan.
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Yamaguchi
authors.affiliation: Kentaroh Yamamoto, Fumio Yamamoto, Hirotsune Igimi, Mami Yamamoto, Department of Surgery, Yamamoto Memorial Hospital, Saga 848-0031, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Yamashita
mesh_terms: D000236:Adenoma / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D002278:Carcinoma in Situ / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D002760:Cholangiopancreatography, Endoscopic Retrograde; D049448:Cholangiopancreatography, Magnetic Resonance; D002763:Cholecystectomy; D003138:Common Bile Duct Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D005260:Female; D005706:Gallbladder Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D009361:Neoplasm Invasiveness; D018297:Neoplasms, Cystic, Mucinous, and Serous / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor
keywords: Intraductal papillary mucinous neoplasm of the bile duct; Tumor thrombi