title: Desmodianone H and uncinanone B, potential tyrosinase inhibitors obtained from Lespedeza maximowiczii by using bioactivity-guided isolation.
abstract: A new bioactive compound, namely desmodianone H(1), and another known compound uncinanone B(2) were first isolated using bioactivity-guided isolation from the leaves of Lespedeza maximowiczii and structures were elucidated by comprehensive analysis of their nuclear magnetic resonance and mass spectrometry data. Compounds 1 and 2 exhibited strong inhibitory effects on mushroom tyrosinase activity.
authors.affiliation: a Department of Bioscience and Biotechnology , Konkuk University , Seoul , Republic of Korea.
authors.forename: Do Yeon
authors.initials: do Y
authors.lastname: Heo
authors.forename: Young Mi
authors.initials: YM
authors.lastname: Kim
authors.forename: Joongku
authors.initials: J
authors.lastname: Lee
authors.forename: Sang-Hong
authors.initials: SH
authors.lastname: Park
authors.forename: Jinki
authors.initials: J
authors.lastname: Kim
authors.forename: Hye Min
authors.initials: HM
authors.lastname: Park
authors.forename: Choong Hwan
authors.initials: CH
authors.lastname: Lee
mesh_terms: D000363:Agaricales / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029884:Lespedeza / Q000737:chemistry*; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D004791:Enzyme Inhibitors; D007529:Isoflavones; C000595990:desmodianone H; C000595991:uncinanone B; D014442:Monophenol Monooxygenase
keywords: Lespedeza maximowiczii; desmodianone H; tyrosinase inhibition activity; uncinanone B