title: Use of an artificial neural network to predict risk factors of nosocomial infection in lung cancer patients.
abstract: Statistical methods to analyze and predict the related risk factors of nosocomial infection in lung cancer patients are various, but the results are inconsistent. A total of 609 patients with lung cancer were enrolled to allow factor comparison using Student's t-test or the Mann-Whitney test or the Chi-square test. Variables that were significantly related to the presence of nosocomial infection were selected as candidates for input into the final ANN model. The area under the receiver operating characteristic (ROC) curve (AUC) was used to evaluate the performance of the artificial neural network (ANN) model and logistic regression (LR) model. The prevalence of nosocomial infection from lung cancer in this entire study population was 20.1% (165/609), nosocomial infections occurring in sputum specimens (85.5%), followed by blood (6.73%), urine (6.0%) and pleural effusions (1.82%). It was shown that long term hospitalization (≥ 22 days, P= 0.000), poor clinical stage (IIIb and IV stage, P=0.002), older age (≥ 61 year old, P=0.023), and use the hormones were linked to nosocomial infection and the ANN model consisted of these four factors .The artificial neural network model with variables consisting of age, clinical stage, time of hospitalization, and use of hormones should be useful for predicting nosocomial infection in lung cancer cases.
authors.affiliation: Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China E-mail : wym0577@163.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.forename: Qin-Shi
authors.initials: QS
authors.lastname: Pan
authors.forename: Wan-Dong
authors.initials: WD
authors.lastname: Hong
authors.forename: Jingye
authors.initials: J
authors.lastname: Pan
authors.forename: Wen-Hui
authors.initials: WH
authors.lastname: Zhang
authors.forename: Gang
authors.initials: G
authors.lastname: Xu
authors.forename: Yu-Min
authors.initials: YM
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003428:Cross Infection / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D006801:Humans; D016015:Logistic Models; D008175:Lung Neoplasms / Q000382:microbiology* / Q000473:pathology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D016571:Neural Networks, Computer; D012372:ROC Curve; D012307:Risk Factors