title: RNA binding of PRC2: promiscuous or well ordered?
abstract: The polycomb repressive complex 2 (PRC2) methylates histones for epigenetic silencing and associates with thousands of protein-coding and noncoding RNAs. How the recruitment of PRC2 to specific sites is facilitated is currently unclear. Two recent studies have deciphered the impact of RNA binding on PRC2 recruitment and activity (Cifuentes-Rojas et al., 2014; Davidovich et al., 2013).
authors.affiliation: Biochemistry Center Regensburg (BZR), University of Regensburg, Universitätsstrasse 31, 93053 Regensburg, Germany. Electronic address: markus.kretz@ur.de.
authors.forename: Markus
authors.initials: M
authors.lastname: Kretz
authors.affiliation: Biochemistry Center Regensburg (BZR), University of Regensburg, Universitätsstrasse 31, 93053 Regensburg, Germany. Electronic address: gunter.meister@ur.de.
authors.forename: Gunter
authors.initials: G
authors.lastname: Meister
mesh_terms: D000818:Animals; D006801:Humans; D063151:Polycomb Repressive Complex 2 / Q000737:chemistry* / Q000378:metabolism*; D062085:RNA, Long Noncoding / Q000737:chemistry*; D012333:RNA, Messenger / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism*
chemical_list: D062085:RNA, Long Noncoding; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; C465658:Tsix transcript, mouse; D063151:Polycomb Repressive Complex 2