title: The effects of bariatric surgery on colorectal cancer risk: systematic review and meta-analysis.
abstract: Obesity is an established risk factor for colorectal cancer (CRC) but the effects of bariatric surgery on CRC incidence are uncertain. A systematic review of six electronic databases identified 3691 articles. Four observational studies met our inclusion criteria and results were pooled using a random effects model. Meta-analysis of these four studies revealed that bariatric surgery was associated with a significantly (p = 0.004) lower CRC incidence (RR = 0.73, 95 % confidence interval, 0.58 - 0.90) when compared with obese non-operated individuals, i.e., bariatric surgery is associated with a 27 % lower CRC risk. However the evidence base is limited and these findings should be confirmed by future studies with improved designs.
authors.forename: Sorena
authors.initials: S
authors.lastname: Afshar
authors.forename: Seamus B
authors.initials: SB
authors.lastname: Kelly
authors.forename: Keith
authors.initials: K
authors.lastname: Seymour
authors.forename: Jose
authors.initials: J
authors.lastname: Lara
authors.forename: Sean
authors.initials: S
authors.lastname: Woodcock
authors.forename: John C
authors.initials: JC
authors.lastname: Mathers
mesh_terms: D050110:Bariatric Surgery; D015179:Colorectal Neoplasms / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D015994:Incidence; D009765:Obesity / Q000150:complications / Q000601:surgery*; D012306:Risk; D012307:Risk Factors