title: At the interface of sensory and motor dysfunctions and Alzheimer's disease.
abstract: Recent evidence indicates that sensory and motor changes may precede the cognitive symptoms of Alzheimer's disease (AD) by several years and may signify increased risk of developing AD. Traditionally, sensory and motor dysfunctions in aging and AD have been studied separately. To ascertain the evidence supporting the relationship between age-related changes in sensory and motor systems and the development of AD and to facilitate communication between several disciplines, the National Institute on Aging held an exploratory workshop titled "Sensory and Motor Dysfunctions in Aging and AD." The scientific sessions of the workshop focused on age-related and neuropathologic changes in the olfactory, visual, auditory, and motor systems, followed by extensive discussion and hypothesis generation related to the possible links among sensory, cognitive, and motor domains in aging and AD. Based on the data presented and discussed at this workshop, it is clear that sensory and motor regions of the central nervous system are affected by AD pathology and that interventions targeting amelioration of sensory-motor deficits in AD may enhance patient function as AD progresses.
authors.affiliation: Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. Electronic address: albers.mark@mgh.harvard.edu.
authors.forename: Mark W
authors.initials: MW
authors.lastname: Albers
authors.affiliation: Jack, Joseph and Morton Mandel School of Applied Social Sciences, Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Grover C
authors.initials: GC
authors.lastname: Gilmore
authors.affiliation: Department of Neurology, Oregon Heath & Science University, Portland, OR, USA.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Kaye
authors.affiliation: SDSU/UCSD Joint Doctoral Program in Clinical Psychology, San Diego State University, San Diego, CA, USA.
authors.forename: Claire
authors.initials: C
authors.lastname: Murphy
authors.affiliation: Volen National Center for Complex Systems and Department of Psychology, Brandeis University, Waltham, MA, USA.
authors.forename: Arthur
authors.initials: A
authors.lastname: Wingfield
authors.affiliation: Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Bennett
authors.affiliation: Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
authors.forename: Adam L
authors.initials: AL
authors.lastname: Boxer
authors.affiliation: Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
authors.forename: Aron S
authors.initials: AS
authors.lastname: Buchman
authors.affiliation: Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA; Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
authors.forename: Karen J
authors.initials: KJ
authors.lastname: Cruickshanks
authors.affiliation: Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
authors.forename: Davangere P
authors.initials: DP
authors.lastname: Devanand
authors.affiliation: Dept. of Neurology, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA.
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Duffy
authors.affiliation: Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA, USA.
authors.forename: Christine M
authors.initials: CM
authors.lastname: Gall
authors.affiliation: Bloedel Hearing Research Center, University of Washington, Seattle, WA, USA.
authors.forename: George A
authors.initials: GA
authors.lastname: Gates
authors.affiliation: Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA; Center on Aging, Medical University of South Carolina, Charleston, SC, USA.
authors.forename: Ann-Charlotte
authors.initials: AC
authors.lastname: Granholm
authors.affiliation: Department of Molecular & Cellular Biology, Harvard University, Cambridge, MA, USA.
authors.forename: Takao
authors.initials: T
authors.lastname: Hensch
authors.affiliation: Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA.
authors.forename: Roee
authors.initials: R
authors.lastname: Holtzer
authors.affiliation: Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
authors.forename: Bradley T
authors.initials: BT
authors.lastname: Hyman
authors.affiliation: Division of Otology, Neurotology, & Skull Base Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.
authors.forename: Frank R
authors.initials: FR
authors.lastname: Lin
authors.affiliation: Departments of Neurology and Pathology, Boston University School of Medicine, Bedford, MA, USA.
authors.forename: Ann C
authors.initials: AC
authors.lastname: McKee
authors.affiliation: Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
authors.forename: John C
authors.initials: JC
authors.lastname: Morris
authors.affiliation: Mayo Alzheimer's Disease Research Center, Mayo Clinic College of Medicine, Rochester, MN, USA.
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Petersen
authors.affiliation: Department of Neurology, Oregon Heath & Science University, Portland, OR, USA.
authors.forename: Lisa C
authors.initials: LC
authors.lastname: Silbert
authors.affiliation: Center for Alzheimer Disease and Related Disorders, Southern Illinois University School of Medicine, Springfield, IL, USA.
authors.forename: Robert G
authors.initials: RG
authors.lastname: Struble
authors.affiliation: Center for Neurodegenerative Disease Research and Institute on Aging, the Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: John Q
authors.initials: JQ
authors.lastname: Trojanowski
authors.affiliation: Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA.
authors.forename: Joe
authors.initials: J
authors.lastname: Verghese
authors.affiliation: Emotional Brain Institute, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA.
authors.forename: Donald A
authors.initials: DA
authors.lastname: Wilson
authors.affiliation: Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
authors.forename: Shunbin
authors.initials: S
authors.lastname: Xu
authors.affiliation: Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
authors.forename: Li I
authors.initials: LI
authors.lastname: Zhang
mesh_terms: D000375:Aging / Q000502:physiology*; D000544:Alzheimer Disease / Q000175:diagnosis / Q000503:physiopathology*; D018450:Disease Progression; D042241:Early Diagnosis; D006801:Humans; D009069:Movement Disorders / Q000175:diagnosis / Q000503:physiopathology*; D054561:National Institute on Aging (U.S.); D012678:Sensation Disorders / Q000175:diagnosis / Q000503:physiopathology*; D014481:United States
keywords: Aging; Alzheimer's disease; Auditory function; Motor; Olfaction; Sensory; Vision