title: Tribbles homolog 3 expression in spermatogonial stem cells of rat testes.
abstract: Tribbles are a family of signal-regulating proteins shown to coordinate the action and the suppression of different pathways. Tribbles homolog 3 (Trib3), the best-studied member of the mammalian tribble family, has a key function in determining cell fate when responding to environmental challenges. Trib3 effects are also modulated by its direct interaction with other signaling molecules. We found that Trib3 is highly expressed in the early development of rat testis, at just the time when the gonocytes resume proliferation to give rise to A spermatogonia. Immunofluorescence staining of cross-sections of rat testis and cultured spermatogonial stem cells (SSCs) also confirmed that Trib3 is expressed in rat SSCs.
authors.affiliation: Key Laboratory of Education Ministry of China for Mammalian Reproductive Biology and Biotechnology, Inner Mongolia University, Hohhot, China; School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Fenhua
authors.initials: F
authors.lastname: Luo
authors.forename: Sachula
authors.initials: S
authors.lastname: Wu
authors.forename: Boyang
authors.initials: B
authors.lastname: Yu
authors.forename: Taodi
authors.initials: T
authors.lastname: Liu
authors.forename: Yingji
authors.initials: Y
authors.lastname: Wu
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D002478:Cells, Cultured; D008297:Male; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D051381:Rats; D013091:Spermatogenesis / Q000502:physiology*; D013093:Spermatogonia / Q000378:metabolism*; D013234:Stem Cells / Q000378:metabolism*; D013737:Testis / Q000254:growth & development / Q000378:metabolism*; D013997:Time Factors
chemical_list: C502443:Trib3 protein, rat; D017346:Protein Serine-Threonine Kinases
keywords: Trib3; rat; spermatogonial stem cells