title: Norcassane- and cassane-type furanoditerpenoids from the seeds of Caesalpinia sappan.
abstract: Three novel furanoditerpenoids, norcaesalpinin J (1) featuring an unusual 20-norcassane hydroperoxide and phangininoxys B (2) and C (3) possessing cassane hemiketal skeletons, were isolated from the seeds of Caesalpinia sappan. Their structures were elucidated by extensive spectroscopic methods. All isolates were evaluated for the cytotoxic activities on three human cancer cell lines.
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100193, PR China.
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Wu
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100193, PR China.
authors.forename: Yin-Di
authors.initials: YD
authors.lastname: Zhu
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100193, PR China.
authors.forename: Zhong-Hao
authors.initials: ZH
authors.lastname: Sun
authors.affiliation: National Engineering Laboratory of Southwest Endangered Medicinal Resources Development, National Development and Reform Commission, Guangxi Botanical Garden of Medicinal Plant, Nanning 530023, PR China.
authors.forename: Jing-Quan
authors.initials: JQ
authors.lastname: Yuan
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, PR China.
authors.forename: Hua
authors.initials: H
authors.lastname: Wei
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100193, PR China.
authors.forename: Xiao-Po
authors.initials: XP
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100193, PR China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100193, PR China.
authors.forename: Jun-Shan
authors.initials: JS
authors.lastname: Yang
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100193, PR China. Electronic address: mgxf18785@163.com.
authors.forename: Guo-Xu
authors.initials: GX
authors.lastname: Ma
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100193, PR China. Electronic address: xdxu@implad.ac.cn.
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Xu
mesh_terms: D029911:Caesalpinia / Q000737:chemistry*; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D015394:Molecular Structure; D012639:Seeds / Q000737:chemistry*
chemical_list: D004224:Diterpenes; C000597492:norcaesalpinin J; C000597493:phangininoxy B; C000597494:phangininoxy C
keywords: Caesalpinia sappan; Cytotoxicity; Norcassane diterpene