title: Peptides come round: using SICLOPPS libraries for early stage drug discovery.
abstract: Cyclic peptides are an emerging class of molecular therapeutics that are increasingly viewed as ideal backbones for modulation of protein-protein interactions. A split-intein based method, termed SICLOPPS, enables the rapid generation of genetically encoded cyclic peptide libraries of around a hundred million members. Here we review recent approaches using SICLOPPS for the discovery of bioactive compounds.
authors.affiliation: Chemistry, University of Southampton, Southampton, SO17 1BJ (UK).
authors.forename: Katherine R
authors.initials: KR
authors.lastname: Lennard
authors.forename: Ali
authors.initials: A
authors.lastname: Tavassoli
mesh_terms: D055808:Drug Discovery; D019151:Peptide Library; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D010957:Plasmids / Q000235:genetics / Q000378:metabolism; D054730:Protein Interaction Domains and Motifs; D014157:Transcription Factors / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D019151:Peptide Library; D010456:Peptides, Cyclic; D014157:Transcription Factors
keywords: SICLOPPS; cyclic peptides; drug discovery; high throughput screening; medicinal chemistry; protein-protein interactions