title: Bio-functional pickles that reduce blood pressure of rats.
abstract: Addition of γ-aminobutyric acid (GABA) and angiotensin converting enzyme (ACE)-inhibitory peptides to the pickles was studied in order to develop a new type of pickles that reduce blood pressure. Based on the outcome of these studies, a new type of fermentation bed composed of rice bran and white miso has been successfully developed. The advantage of such pickles is that they not only contain both GABA and ACE-inhibitory peptides, but also that their taste and flavor are excellent, with colors close to the original ones. The new type of pickles could temporarily reduce blood pressure in two types of rats, spontaneously hypertensive rats and NaCl-sensitive model rats. Thus, the newly developed pickles appear to be beneficial for pickle business.
authors.affiliation: a Kyoto Institute of Technology , Sakyo-ku, Kyoto , Japan.
authors.forename: Kohei
authors.initials: K
authors.lastname: Oda
authors.forename: Takanori
authors.initials: T
authors.lastname: Imanishi
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Yamane
authors.forename: Yoshie
authors.initials: Y
authors.lastname: Ueno
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Mori
mesh_terms: D000284:Administration, Oral; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000032:analysis; D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D003116:Color; D005285:Fermentation; D005511:Food Handling; D005527:Food, Fortified; D008297:Male; D012275:Oryza; D051381:Rats; D011918:Rats, Inbred SHR; D012965:Sodium Chloride / Q000494:pharmacology; D045730:Soy Foods; D013649:Taste; D005680:gamma-Aminobutyric Acid / Q000032:analysis
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D012965:Sodium Chloride; D005680:gamma-Aminobutyric Acid
keywords: angiotensin converting enzyme (ACE)-inhibitory peptides; anti-hypertensive effects; pickles; spontaneously hypertensive rats; γ-aminobutyric acid (GABA)