title: Combining single-molecule imaging and single-channel electrophysiology.
abstract: Combining simultaneous single-molecule fluorescence measurements of ion channel conformational change with single-channel electrophysiology would enable a direct link between structure and function. Such methods would help us to create a truly molecular "movie" of how these important biomolecules work. Here we review past and recent progress toward this goal.
authors.affiliation: Department of Chemistry, Oxford University, Oxford OX13TA, UK.
authors.forename: Eve E
authors.initials: EE
authors.lastname: Weatherill
authors.affiliation: Department of Chemistry, Oxford University, Oxford OX13TA, UK. Electronic address: mark.wallace@chem.ox.ac.uk.
authors.forename: Mark I
authors.initials: MI
authors.lastname: Wallace
mesh_terms: D000818:Animals; D055724:Electrophysiological Phenomena; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007473:Ion Channels / Q000502:physiology*
chemical_list: D007473:Ion Channels
keywords: artificial lipid bilayer; patch-clamp fluorometry; single-molecule fluorescence