title: Motoric cognitive risk syndrome: multicountry prevalence and dementia risk.
abstract: OBJECTIVE
  Our objective is to report prevalence of motoric cognitive risk syndrome (MCR), a newly described predementia syndrome characterized by slow gait and cognitive complaints, in multiple countries, and its association with dementia risk.
  
  
  METHODS
  Pooled MCR prevalence analysis of individual data from 26,802 adults without dementia and disability aged 60 years and older from 22 cohorts from 17 countries. We also examined risk of incident cognitive impairment (Mini-Mental State Examination decline ≥4 points) and dementia associated with MCR in 4,812 individuals without dementia with baseline Mini-Mental State Examination scores ≥25 from 4 prospective cohort studies using Cox models adjusted for potential confounders.
  
  
  RESULTS
  At baseline, 2,808 of the 26,802 participants met MCR criteria. Pooled MCR prevalence was 9.7% (95% confidence interval [CI] 8.2%-11.2%). MCR prevalence was higher with older age but there were no sex differences. MCR predicted risk of developing incident cognitive impairment in the pooled sample (adjusted hazard ratio [aHR] 2.0, 95% CI 1.7-2.4); aHRs were 1.5 to 2.7 in the individual cohorts. MCR also predicted dementia in the pooled sample (aHR 1.9, 95% CI 1.5-2.3). The results persisted even after excluding participants with possible cognitive impairment, accounting for early dementia, and diagnostic overlap with other predementia syndromes.
  
  
  CONCLUSIONS
  MCR is common in older adults, and is a strong and early risk factor for cognitive decline. This clinical approach can be easily applied to identify high-risk seniors in a wide variety of settings.
authors.affiliation: Authors' affiliations are listed at the end of the article. joe.verghese@einstein.yu.edu.
authors.forename: Joe
authors.initials: J
authors.lastname: Verghese
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authors.forename: Cedric
authors.initials: C
authors.lastname: Annweiler
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authors.forename: Emmeline
authors.initials: E
authors.lastname: Ayers
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authors.forename: Nir
authors.initials: N
authors.lastname: Barzilai
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authors.forename: Olivier
authors.initials: O
authors.lastname: Beauchet
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authors.forename: David A
authors.initials: DA
authors.lastname: Bennett
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authors.forename: Stephanie A
authors.initials: SA
authors.lastname: Bridenbaugh
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authors.forename: Aron S
authors.initials: AS
authors.lastname: Buchman
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authors.forename: Michele L
authors.initials: ML
authors.lastname: Callisaya
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authors.forename: Richard
authors.initials: R
authors.lastname: Camicioli
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authors.forename: Benjamin
authors.initials: B
authors.lastname: Capistrant
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authors.forename: Somnath
authors.initials: S
authors.lastname: Chatterji
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authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: De Cock
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authors.forename: Luigi
authors.initials: L
authors.lastname: Ferrucci
authors.affiliation: Authors' affiliations are listed at the end of the article.
authors.forename: Nir
authors.initials: N
authors.lastname: Giladi
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authors.forename: Jack M
authors.initials: JM
authors.lastname: Guralnik
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authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Hausdorff
authors.affiliation: Authors' affiliations are listed at the end of the article.
authors.forename: Roee
authors.initials: R
authors.lastname: Holtzer
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authors.forename: Ki Woong
authors.initials: KW
authors.lastname: Kim
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authors.forename: Paul
authors.initials: P
authors.lastname: Kowal
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authors.forename: Reto W
authors.initials: RW
authors.lastname: Kressig
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authors.forename: Jae-Young
authors.initials: JY
authors.lastname: Lim
authors.affiliation: Authors' affiliations are listed at the end of the article.
authors.forename: Susan
authors.initials: S
authors.lastname: Lord
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authors.forename: Kenichi
authors.initials: K
authors.lastname: Meguro
authors.affiliation: Authors' affiliations are listed at the end of the article.
authors.forename: Manuel
authors.initials: M
authors.lastname: Montero-Odasso
authors.affiliation: Authors' affiliations are listed at the end of the article.
authors.forename: Susan W
authors.initials: SW
authors.lastname: Muir-Hunter
authors.affiliation: Authors' affiliations are listed at the end of the article.
authors.forename: Mohan L
authors.initials: ML
authors.lastname: Noone
authors.affiliation: Authors' affiliations are listed at the end of the article.
authors.forename: Lynn
authors.initials: L
authors.lastname: Rochester
authors.affiliation: Authors' affiliations are listed at the end of the article.
authors.forename: Velandai
authors.initials: V
authors.lastname: Srikanth
authors.affiliation: Authors' affiliations are listed at the end of the article.
authors.forename: Cuiling
authors.initials: C
authors.lastname: Wang
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000453:epidemiology* / Q000401:mortality; D003704:Dementia / Q000453:epidemiology* / Q000401:mortality; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D015995:Prevalence; D011446:Prospective Studies; D012306:Risk; D018570:Risk Assessment