title: An increased proportion of circulating Th22 and Tc22 cells in psoriasis.
abstract: Psoriasis is a common dermatosis mediated by T cells. This study investigated the correlation of Th22 cells and Tc22 cells with psoriasis. A total of 30 psoriasis patients and 11 age- and sex-matched healthy controls were recruited for this study. The proportions of circulating Th22 and Tc22 cells, expression of aryl hydrocarbon receptor, and IL-22 levels in the psoriasis patients were significantly higher than those in the control subjects (p<0.05). There was a positive correlation between the proportion of circulating Th22 cells, IL-22 levels, and PASI score. The IL-22 levels and PASI score were also positively correlated. There was no correlation between the proportion of circulating Tc22 cells and IL-22 level or PASI score. These data are consistent with Th22 cells involvement in the pathogenesis of psoriasis.
authors.affiliation: Department of Dermatology and Venereology, 1st Affiliated Hospital of DaLian Medical University, China.
authors.forename: Li
authors.initials: L
authors.lastname: Luan
authors.affiliation: Department of Dermatology and Venereology, 1st Affiliated Hospital of DaLian Medical University, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Ding
authors.affiliation: Department of Dermatology and Venereology, 1st Affiliated Hospital of DaLian Medical University, China.
authors.forename: Shixin
authors.initials: S
authors.lastname: Han
authors.affiliation: Department of Dermatology and Venereology, Shenzhen Hospital of Hong Kong University, China.
authors.forename: Zhenying
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Dermatology and Venereology, 1st Affiliated Hospital of DaLian Medical University, China; Department of Dermatology and Venereology, Shenzhen Hospital of Hong Kong University, China. Electronic address: lxmdl_1956@126.com.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Liu
mesh_terms: D000328:Adult; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007378:Interleukins / Q000096:biosynthesis / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000276:immunology*; D060888:Real-Time Polymerase Chain Reaction; D018336:Receptors, Aryl Hydrocarbon / Q000096:biosynthesis; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D000097043:Interleukin-22
chemical_list: D007378:Interleukins; D018336:Receptors, Aryl Hydrocarbon; D000097043:Interleukin-22
keywords: AHR; IL-22; Psoriasis; Tc22 cell; Th22 cell