title: [Patients with inherited trombophilia and recurrent pregnancy loss: incidence].
abstract: BACKGROUND
  Inherited thrombophilia is a genetic tendency to suffer thrombotic events clinically evident at an early age, with frequent re- currences without apparent cause. In recent years thrombophilia has earned a place as a primary risk factor for abnormal pregnancy.
  
  
  OBJECTIVE
  To determine the incidence of hereditary thrombophilia in patients with recurrent pregnancy loss.
  
  
  METHODS
  A retrospective, linear and descriptive study was conducted at Clinic of Reproduction IMMUNOREP with patients treated from January 2007 to December 2012. The study included patients with a diagnosis of recurrent pregnancy loss and inherited thrombophilia with laboratory studies of thrombophilia including different genes: G1619A (factor V Leiden), R2 H1299R (factor V polymorphism), C677T (methylenetetrahydrofolate reductase enzyme polymorphism), A1298C (methylenetetrahydrofolate reductase enzyme mutation), G20210A (mutation of the prothrombin gene), V34L (factor XIII polymorphism), 455G > A (fibrinogen gene mutation), 4G/5G (plasminogen activator inhibitor) and a/b L33P (ribosomal polymorphism of methylenetetrahydrofolate reductase enzyme).
  
  
  RESULTS
  211 files were reviewed and only 10.4% of patients were negative for hereditary thrombophilia, a percentage that is consistent with the results of different series of studies in patients with unexplained recurrent pregnancy loss. The most prevalent genetic condition was 4G/5G (plasminogen activator inhibitor, 85.5%) in homozygous and heterozygous with 63.4% (120) and 22.4% (42), respectively.
  
  
  CONCLUSIONS
  It was demonstrated the direct relationship between thrombophilia and recurrent pregnancy loss depending on whether the patient is heterozygous or homozygous for the disease.
authors.forename: José Daniel
authors.initials: JD
authors.lastname: Flores-Alatriste
authors.forename: Sara
authors.initials: S
authors.lastname: Jacobo-Nájera
authors.forename: Rubén
authors.initials: R
authors.lastname: Segura-Rodríguez
authors.forename: Jorge Jaroslav
authors.initials: JJ
authors.lastname: Stern-Colin y Nunes
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D005260:Female; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D015994:Incidence; D009154:Mutation; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011248:Pregnancy Complications / Q000235:genetics*; D012189:Retrospective Studies; D012307:Risk Factors; D019851:Thrombophilia / Q000150:complications* / Q000235:genetics