title: Association of inflammatory sialoproteins, lipid peroxides and serum magnesium levels with cardiometabolic risk factors in obese children of South Indian population.
abstract: The Incidence of childhood obesity and metabolic syndrome is increasing even in rural and semi-urban regions of India. Adipose tissue mass secretes several inflammatory proteins, which could potentially alter the metabolic processes, leading to several complications at the later stages of life. With limited studies on protein bound sialic acid (PBSA) as a marker of oxidative stress mediated inflammation in obese children, this study was aimed to assess and correlate PBSA with lipid peroxidation and other cardiometabolic risk factors like Insulin Resistance (IR), serum magnesium, and high sensitive C reactive Protein (hsCRP) levels in order to provide an insight into the degree of systemic inflammation and oxidative stress. This study included 62 obese children (≥95% percentile of the CDC chart) and 60 non obese controls. This study documents significant higher levels of PBSA, IR, Malondialdehyde (MDA), hsCRP and uric acid in obese children (p<0.001). PBSA was associated with IR, hsCRP, uric acid, hypomagnesaemia. Higher degrees of oxidative stress, Insulin resistance and low serum magnesium levels were noted in obese children. PBSA and hsCRP levels were elevated and were associated with Insulin resistance in obese children of South Indian population.
authors.affiliation: Department of Biochemistry, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth [SBV], Pillaiyarkuppam, Puducherry-607402, India;
authors.forename: G
authors.initials: G
authors.lastname: Niranjan
authors.affiliation: Department of Biochemistry, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth [SBV], Pillaiyarkuppam, Puducherry-607402, India;
authors.forename: D
authors.initials: D
authors.lastname: Anitha
authors.affiliation: Department of Biochemistry, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth [SBV], Pillaiyarkuppam, Puducherry-607402, India;
authors.forename: A R
authors.initials: AR
authors.lastname: Srinivasan
authors.affiliation: Department of Biochemistry, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth [SBV], Pillaiyarkuppam, Puducherry-607402, India;
authors.forename: V Kuzhandai
authors.initials: VK
authors.lastname: Velu
authors.affiliation: Department of Pediatrics, JIPMER, Puducherry-605006, India.
authors.forename: C
authors.initials: C
authors.lastname: Venkatesh
authors.affiliation: Department of Biochemistry, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth [SBV], Pillaiyarkuppam, Puducherry-607402, India;
authors.forename: M Sathish
authors.initials: MS
authors.lastname: Babu
authors.affiliation: Department of Biochemistry, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth [SBV], Pillaiyarkuppam, Puducherry-607402, India;
authors.forename: R
authors.initials: R
authors.lastname: Ramesh
authors.affiliation: Department of Biochemistry, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth [SBV], Pillaiyarkuppam, Puducherry-607402, India;
authors.forename: S
authors.initials: S
authors.lastname: Saha
keywords: Childhood Obesity; Insulin Resistance; Malondialdehyde; Protein Bound Sialic Acid; Serum Magnesium; Type 2 Diabetes Mellitus; hsCRP