title: [Perspectives of disodium salt 2.4-di(1-metoxyethyl)-deuteroporphyrin - IX ("Dimegin") application for photodynamic therapy in non-oncologic cases].
abstract: Effects of disodium salt 2,4-di(1-metoxyethyl)-deuteroporphyrine-IX (Dimegin) and the light from Soret band (»395-405 nm) at the viability of microbial cells and at their potential to form microbial biofilms have been compared with traditional antiseptics. Irradiation of microbial cells of S. aureus, E. coli, C. albicans and others with diode light (power density 0.05 Wt/cm2) caused a bactericidial effect similar to that obtained with standard anticeptics (chlorhexidine and dioxidine). A comparative study of the effectiveness of Dimegin and Photoditazine (a soluble salt of chlorine e6) as photosensitizers have been performed using the test system of erythrocyte hemolysis in vitro under irradiation with light from the Sore band. Results have shown insignificant difference in the photodynamic effect with similar doses of absorbed light and preparation concentration.
authors.forename: V M
authors.initials: VM
authors.lastname: Bondarenko
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Alekseev
authors.forename: O V
authors.initials: OV
authors.lastname: Mislavskiĭ
authors.forename: G V
authors.initials: GV
authors.lastname: Ponomarev
mesh_terms: D002176:Candida albicans / Q000187:drug effects / Q000254:growth & development; D002710:Chlorhexidine / Q000494:pharmacology; D003905:Deuteroporphyrins / Q000494:pharmacology*; D004202:Disinfectants / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D005944:Glucosamine / Q000031:analogs & derivatives / Q000494:pharmacology; D006801:Humans; D008027:Light; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability / Q000187:drug effects; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000494:pharmacology*; D011810:Quinoxalines / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development
chemical_list: D003905:Deuteroporphyrins; D004202:Disinfectants; D017319:Photosensitizing Agents; D011810:Quinoxalines; C115898:dimegin(2,4-di-methoxyethyl)-deuteroporphyrin IX; C001077:dioxidine; C047635:N-methylglucosamine; D005944:Glucosamine; D002710:Chlorhexidine
keywords: microbial cells; photodynamic effect; photodynamic therapy; photosensitizers