title: Molecular chaperones, cochaperones, and ubiquitination/deubiquitination system: involvement in the production of high quality spermatozoa.
abstract: Spermatogenesis is a complex process in which mitosis, meiosis, and cell differentiation events coexist. The need to guarantee the production of qualitatively functional spermatozoa has evolved into several control systems that check spermatogenesis progression/sperm maturation and tag aberrant gametes for degradation. In this review, we will focus on the importance of the evolutionarily conserved molecular pathways involving molecular chaperones belonging to the superfamily of heat shock proteins (HSPs), their cochaperones, and ubiquitination/deubiquitination system all over the spermatogenetic process. In this respect, we will discuss the conserved role played by the DNAJ protein Msj-1 (mouse sperm cell-specific DNAJ first homologue) and the deubiquitinating enzyme Ubpy (ubiquitin-specific processing protease-y) during the spermiogenesis in both mammals and nonmammalian vertebrates.
authors.affiliation: Dipartimento di Scienze Motorie e del Benessere, Università di Napoli Parthenope, Via Medina 40, 80133 Napoli, Italy.
authors.forename: Rosaria
authors.identifier: 0000-0003-2174-1118
authors.initials: R
authors.lastname: Meccariello
authors.affiliation: Dipartimento di Medicina Sperimentale, Sezione "F. Bottazzi", Seconda Università di Napoli, Via Costantinopoli 16, 80138 Napoli, Italy.
authors.forename: Rosanna
authors.identifier: 0000-0003-3631-1794
authors.initials: R
authors.lastname: Chianese
authors.affiliation: Dipartimento di Medicina Sperimentale, Sezione "F. Bottazzi", Seconda Università di Napoli, Via Costantinopoli 16, 80138 Napoli, Italy.
authors.forename: Vincenza
authors.initials: V
authors.lastname: Ciaramella
authors.affiliation: Dipartimento di Medicina Sperimentale, Sezione "F. Bottazzi", Seconda Università di Napoli, Via Costantinopoli 16, 80138 Napoli, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Fasano
authors.affiliation: Dipartimento di Medicina Sperimentale, Sezione "F. Bottazzi", Seconda Università di Napoli, Via Costantinopoli 16, 80138 Napoli, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Pierantoni
mesh_terms: D000818:Animals; D010450:Endopeptidases / Q000235:genetics* / Q000378:metabolism; D056827:Endosomal Sorting Complexes Required for Transport / Q000235:genetics* / Q000378:metabolism; D050956:HSP40 Heat-Shock Proteins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008297:Male; D018832:Molecular Chaperones / Q000235:genetics* / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000378:metabolism; D013091:Spermatogenesis / Q000235:genetics*; D013094:Spermatozoa / Q000378:metabolism / Q000473:pathology; D043222:Ubiquitin Thiolesterase / Q000235:genetics* / Q000378:metabolism; D054875:Ubiquitination / Q000235:genetics; D014714:Vertebrates / Q000235:genetics / Q000502:physiology
chemical_list: C485565:DNAJB6 protein, human; D056827:Endosomal Sorting Complexes Required for Transport; D050956:HSP40 Heat-Shock Proteins; D018832:Molecular Chaperones; D009419:Nerve Tissue Proteins; D010450:Endopeptidases; C541534:USP8 protein, human; D043222:Ubiquitin Thiolesterase