title: Design and biocompatibility of endovascular aneurysm filling devices.
abstract: The rupture of an intracranial aneurysm, which can result in severe mental disabilities or death, affects approximately 30,000 people in the United States annually. The traditional surgical method of treating these arterial malformations involves a full craniotomy procedure, wherein a clip is placed around the aneurysm neck. In recent decades, research and device development have focused on new endovascular treatment methods to occlude the aneurysm void space. These methods, some of which are currently in clinical use, utilize metal, polymeric, or hybrid devices delivered via catheter to the aneurysm site. In this review, we present several such devices, including those that have been approved for clinical use, and some that are currently in development. We present several design requirements for a successful aneurysm filling device and discuss the success or failure of current and past technologies. We also present novel polymeric-based aneurysm filling methods that are currently being tested in animal models that could result in superior healing.
authors.affiliation: Department of Biomedical Engineering, Texas A&M University, 3120 TAMU, College Station, Texas, 77843.
authors.forename: Jennifer N
authors.initials: JN
authors.lastname: Rodriguez
authors.forename: Wonjun
authors.initials: W
authors.lastname: Hwang
authors.forename: John
authors.initials: J
authors.lastname: Horn
authors.forename: Todd L
authors.initials: TL
authors.lastname: Landsman
authors.forename: Anthony
authors.initials: A
authors.lastname: Boyle
authors.forename: Mark A
authors.initials: MA
authors.lastname: Wierzbicki
authors.forename: Sayyeda M
authors.initials: SM
authors.lastname: Hasan
authors.forename: Douglas
authors.initials: D
authors.lastname: Follmer
authors.forename: Jesse
authors.initials: J
authors.lastname: Bryant
authors.forename: Ward
authors.initials: W
authors.lastname: Small
authors.forename: Duncan J
authors.initials: DJ
authors.lastname: Maitland
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D001807:Blood Vessel Prosthesis; D006801:Humans; D002532:Intracranial Aneurysm / Q000628:therapy*; D011474:Prosthesis Design
chemical_list: D001672:Biocompatible Materials
keywords: aneurysm filling device; embolization; endovascular; intracranial aneurysm; shape memory polymer