title: [Influence of mydocalm on the degree of intra-abdominal hypertension and local blood circulation in the intestinal wall in experiment].
abstract: The effect of mydocalm (tolperison, 5 mg/kg single dose) on the dynamics of intra-abdominal hypertension (IAH), blood circulation regulation, and oxygen balance in the tissues of intestinal wall were studied in acute experiments on rabbits. Using a special stand of original design, the initial IAH level was modeled at 200 mm H2O with the subsequent stopping of further receipt of liquid during 3 hours in an elastic container in the abdominal cavity. During 3-h observation without drug administration, no changes in IAH due to the tone of muscles of the frontal abdominal wall takes place, but there is progressive deceleration of local blood flow (-35.33 + 0.99%, p < 0.01), suppressed dilation (-20.02 + 0.54%, p < 0.01) and constriction (-60.45 + 1.17%, p < 0.01) reactivity of vessels, and decreased oxygen tension (-47.18 + 0.75%, p < 0.01) in the intestinal wall at the end of experiment. The introduction of mydocalm reduces the tone of muscles of the frontal abdominal wall, which leads to a decrease in IAH (maximum effect after 1.5 hours, -20.81 + 0.84%, p < 0.01) and prevents decrease in the local blood flow (-26.77 + 0.41%, p < 0.01), suppression of dilation (-16.51 + 0.34%, p < 0.01) and constriction (-37.85 + 0.61%, p < 0.01) reactivity of vessels, and reduction in oxygen tension (-36.60 + 1.18%, p < 0.01) at the end of experiment. The administration of mydocalm can extend the limits of application of a conservative therapy for patients with IAH and to improve the results.
authors.forename: V I
authors.initials: VI
authors.lastname: Sapegin
authors.forename: I D
authors.initials: ID
authors.lastname: Sapegin
authors.forename: F N
authors.initials: FN
authors.lastname: Il'chenko
mesh_terms: D000818:Animals; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000473:pathology / Q000503:physiopathology*; D007422:Intestines / Q000098:blood supply* / Q000473:pathology / Q000503:physiopathology; D059325:Intra-Abdominal Hypertension / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D009125:Muscle Relaxants, Central / Q000494:pharmacology*; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects*; D014049:Tolperisone / Q000494:pharmacology*
chemical_list: D009125:Muscle Relaxants, Central; D014049:Tolperisone