title: Mega roles of microRNAs in regulation of skeletal muscle health and disease.
abstract: Skeletal muscle is a dynamic tissue with remarkable plasticity. Skeletal muscle growth and regeneration are highly organized processes thus it is not surprising that a high degree of complexity exists in the regulation of these processes. Recent discovery of non-coding microRNAs (miRNAs) has prompted extensive research in understanding the roles of these molecules in skeletal muscle. Research so far shows that miRNAs play a very significant role at every aspect of muscle biology. Besides muscle growth, development, and regeneration miRNAs are also involved in the pathology of muscle diseases and metabolism. In this review, recent advancements in miRNA function during myogenesis, exercise, atrophy, aging, and dystrophy are discussed.
authors.affiliation: Department of Biochemistry, YLL School of Medicine, National University of Singapore Singapore, Singapore.
authors.forename: Mridula
authors.initials: M
authors.lastname: Sharma
authors.affiliation: Department of Biochemistry, YLL School of Medicine, National University of Singapore Singapore, Singapore.
authors.forename: Prasanna Kumar
authors.initials: PK
authors.lastname: Juvvuna
authors.affiliation: Department of Biochemistry, YLL School of Medicine, National University of Singapore Singapore, Singapore.
authors.forename: Himani
authors.initials: H
authors.lastname: Kukreti
authors.affiliation: Brenner Centre for Molecular Medicine, Singapore Institute for Clinical Sciences (ASTAR) Singapore, Singapore.
authors.forename: Craig
authors.initials: C
authors.lastname: McFarlane
keywords: aging; atrophy signaling; exercise; miRNAs; myogenesis