title: The Ras superfamily G-proteins.
abstract: The Ras superfamily G-proteins are monomeric proteins of approximately 21kDa that act as a molecular switch to regulate a variety of cellular processes. The structure of the Ras superfamily G-proteins, their regulators as well as posttranslational modification of these proteins leading to their membrane association have been elucidated. The Ras superfamily G-proteins interact at their effector domains with their downstream effectors via protein-protein interactions. Mutational activation or overexpression of the Ras superfamily G-proteins has been observed in a number of human cancer cases. Over the years, a variety of approaches to inhibit the Ras superfamily G-proteins have been developed. These different approaches are discussed in this volume.
authors.affiliation: Department of Microbiology, Immunology and Molecular Genetics, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California, USA.
authors.forename: Ashley L
authors.initials: AL
authors.lastname: Tetlow
authors.affiliation: Department of Microbiology, Immunology and Molecular Genetics, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California, USA. Electronic address: fuyut@microbio.ucla.edu.
authors.forename: Fuyuhiko
authors.initials: F
authors.lastname: Tamanoi
mesh_terms: D000818:Animals; D006801:Humans; D015398:Signal Transduction / Q000502:physiology; D018631:ras Proteins / Q000378:metabolism*
chemical_list: D018631:ras Proteins
keywords: Arf; Crystal structure; Effectors; G-motifs; GAP; GEF; Membrane association; NMR structure; Posttranslational modification; Rab; Ran; Ras; Ras superfamily G-proteins; Rho