title: Ferulaldehyde and lupeol as direct and indirect antimicrobial compounds from Cordia gilletii (Boraginaceae) root barks.
abstract: Cordia gilletii De Wild (Boraginaceae), a medicinal plant used against infectious diseases in the Democratic Republic of Congo, was investigated for direct and indirect antimicrobial properties. On one hand, the methanol extract is active against many pathogenic bacteria, including resistant strains. Its bio-guided fractionation led to the isolation of ferulaldehyde; this compound showed antimicrobial and antioxidant properties that may support the activity we observed for the methanol extract and some of the traditional uses of C. gilletii. On the other hand, the n-hexane extract of root barks possesses indirect antimicrobial properties, enhancing the activity of antibiotics against methicillin-resistant Staphylococcus aureus (MRSA). The fractionation of this extract led to the isolation of lupeol, which decreases the minimum inhibitory concentration of several antibiotics (4 to 8 fold) against MRSA and contributes to the effects observed for the raw n-hexane extract.
authors.forename: Philippe N
authors.initials: PN
authors.lastname: Okusa
authors.forename: Caroline
authors.initials: C
authors.lastname: Stévigny
authors.forename: Marie
authors.initials: M
authors.lastname: Névraumont
authors.forename: Michel
authors.initials: M
authors.lastname: Gelbcke
authors.forename: Pierre
authors.initials: P
authors.lastname: Van Antwerpen
authors.forename: Jean Claude
authors.initials: JC
authors.lastname: Braekman
authors.forename: Pierre
authors.initials: P
authors.lastname: Duez
mesh_terms: D000447:Aldehydes / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D031213:Cordia / Q000737:chemistry*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D053978:Pentacyclic Triterpenes / Q000494:pharmacology*; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D000094042:Lupanes
chemical_list: D000447:Aldehydes; D000890:Anti-Infective Agents; D053978:Pentacyclic Triterpenes; D010936:Plant Extracts; C000591725:ferulaldehyde; C010480:lupeol; D000094042:Lupanes