title: Preparation of cellulose based microspheres by combining spray coagulating with spray drying.
abstract: Porous microspheres of regenerated cellulose with size in range of 1-2 μm and composite microspheres of chitosan coated cellulose with size of 1-3 μm were obtained through a two-step spray-assisted approach. The spray coagulating process must combine with a spray drying step to guarantee the formation of stable microspheres of cellulose. This approach exhibits the following two main virtues. First, the preparation was performed using aqueous solution of cellulose as precursor in the absence of organic solvent and surfactant; Second, neither crosslinking agent nor separated crosslinking process was required for formation of stable microspheres. Moreover, the spray drying step also provided us with the chance to encapsulate guests into the resultant cellulose microspheres. The potential application of the cellulose microspheres acting as drug delivery vector has been studied in two PBS (phosphate-buffered saline) solution with pH values at 4.0 and 7.4 to mimic the environments of stomach and intestine, respectively.
authors.affiliation: Collaborative Innovation Center for Marine Biomass Fibers, Materials and Textiles of Shandong Province, Laboratory of New Fiber Materials and Modern Textile, Growing Basis for State Key Laboratory, College of Chemistry, Chemical Engineering and Environment, Qingdao University, Qingdao 266071, China.
authors.forename: Qiao
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Collaborative Innovation Center for Marine Biomass Fibers, Materials and Textiles of Shandong Province, Laboratory of New Fiber Materials and Modern Textile, Growing Basis for State Key Laboratory, College of Chemistry, Chemical Engineering and Environment, Qingdao University, Qingdao 266071, China.
authors.forename: Aiping
authors.initials: A
authors.lastname: Fu
authors.affiliation: Collaborative Innovation Center for Marine Biomass Fibers, Materials and Textiles of Shandong Province, Laboratory of New Fiber Materials and Modern Textile, Growing Basis for State Key Laboratory, College of Chemistry, Chemical Engineering and Environment, Qingdao University, Qingdao 266071, China. Electronic address: lhl@qdu.edu.cn.
authors.forename: Hongliang
authors.initials: H
authors.lastname: Li
authors.affiliation: Collaborative Innovation Center for Marine Biomass Fibers, Materials and Textiles of Shandong Province, Laboratory of New Fiber Materials and Modern Textile, Growing Basis for State Key Laboratory, College of Chemistry, Chemical Engineering and Environment, Qingdao University, Qingdao 266071, China.
authors.forename: Jingquan
authors.initials: J
authors.lastname: Liu
authors.affiliation: Collaborative Innovation Center for Marine Biomass Fibers, Materials and Textiles of Shandong Province, Laboratory of New Fiber Materials and Modern Textile, Growing Basis for State Key Laboratory, College of Chemistry, Chemical Engineering and Environment, Qingdao University, Qingdao 266071, China.
authors.forename: Peizhi
authors.initials: P
authors.lastname: Guo
authors.affiliation: Collaborative Innovation Center for Marine Biomass Fibers, Materials and Textiles of Shandong Province, Laboratory of New Fiber Materials and Modern Textile, Growing Basis for State Key Laboratory, College of Chemistry, Chemical Engineering and Environment, Qingdao University, Qingdao 266071, China; School of Chemical Engineering, The University of Queensland, St Lucia, Brisbane 4072, QLD, Australia.
authors.forename: Xiu Song
authors.initials: XS
authors.lastname: Zhao
authors.affiliation: Collaborative Innovation Center for Marine Biomass Fibers, Materials and Textiles of Shandong Province, Laboratory of New Fiber Materials and Modern Textile, Growing Basis for State Key Laboratory, College of Chemistry, Chemical Engineering and Environment, Qingdao University, Qingdao 266071, China.
authors.forename: Lin Hua
authors.initials: LH
authors.lastname: Xia
mesh_terms: D002482:Cellulose / Q000737:chemistry* / Q000648:ultrastructure; D048271:Chitosan / Q000737:chemistry; D003890:Desiccation; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding / Q000295:instrumentation; D004867:Equipment Design; D008863:Microspheres; D016062:Porosity
chemical_list: D004337:Drug Carriers; D002482:Cellulose; D048271:Chitosan
keywords: Cellulose microspheres; Coagulating bath; Drug delivery; Spray coagulating; Spray drying