title: A three-dimensional interpenetrating electrode of reduced graphene oxide for selective detection of dopamine.
abstract: Electrochemical detection of dopamine plays an important role in medical diagnosis. In this paper, we report a three-dimensional (3D) interpenetrating graphene electrode fabricated by electrochemical reduction of graphene oxide for selective detection of dopamine. This electrochemically reduced graphene oxide (ErGO) electrode was used directly without further functionalization or blending with other functional materials. This electrode can efficiently lower the oxidation potential of ascorbic acid; thus, it is able to selectively detect dopamine in the presence of ascorbic acid and uric acid. The ErGO-based biosensor exhibited a linear response towards dopamine in the concentration range of 0.1-10 μM with a low detection limit of 0.1 μM. Furthermore, this electrode has good reproducibility and environmental stability, and can be used to analyse real samples.
authors.affiliation: Department of Chemistry, Tsinghua University, Beijing 100084, People's Republic of China. gshi@tsinghua.edu.cn.
authors.forename: Xiaowen
authors.initials: X
authors.lastname: Yu
authors.forename: Kaixuan
authors.initials: K
authors.lastname: Sheng
authors.forename: Gaoquan
authors.initials: G
authors.lastname: Shi
mesh_terms: D001205:Ascorbic Acid / Q000032:analysis; D015374:Biosensing Techniques / Q000295:instrumentation; D004298:Dopamine / Q000032:analysis / Q000097:blood*; D055664:Electrochemical Techniques / Q000295:instrumentation*; D004566:Electrodes; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D057230:Limit of Detection; D010084:Oxidation-Reduction; D010087:Oxides / Q000737:chemistry*; D015203:Reproducibility of Results; D014527:Uric Acid / Q000032:analysis
chemical_list: D010087:Oxides; D014527:Uric Acid; D006108:Graphite; D001205:Ascorbic Acid; D004298:Dopamine