title: Insight into the therapeutic aspects of 'Zeta-Chain Associated Protein Kinase 70 kDa' inhibitors: a review.
abstract: Zeta-Chain Associated Protein Kinase 70 kDa (ZAP-70), a member of Syk family (non-receptor protein tyrosine kinase family), has an imperative function in the immune cell signaling in T cells. Its role in T-cell development has been established by the severe combined immune deficiency syndrome in ZAP-70 deficient humans. Moreover, defects in T-cell activation and downstream signaling events were observed in T-cells that lack ZAP-70. Thus, the crucial role of ZAP-70 in the development and activation of T-cell and its predominant expression in T-cells make it a logical target for the treatment of pathological conditions related to abnormal T-cell responses. The present review article portrays the domain structure of ZAP-70 along with its implication in T-cell signaling. Additionally, varied ZAP-70 inhibitors published in different patents and papers have also been reviewed.
authors.affiliation: Molecular Modeling Lab (MML), Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab 147002, India.
authors.forename: Maninder
authors.initials: M
authors.lastname: Kaur
authors.affiliation: Molecular Modeling Lab (MML), Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab 147002, India.
authors.forename: Manjinder
authors.initials: M
authors.lastname: Singh
authors.affiliation: Molecular Modeling Lab (MML), Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab 147002, India. Electronic address: omsilakari@rediffmail.com.
authors.forename: Om
authors.initials: O
authors.lastname: Silakari
mesh_terms: D000818:Animals; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology*; D006801:Humans; D008213:Lymphocyte Activation; D017434:Protein Structure, Tertiary; D016511:Severe Combined Immunodeficiency / Q000201:enzymology / Q000235:genetics; D015398:Signal Transduction / Q000502:physiology*; D013601:T-Lymphocytes / Q000166:cytology / Q000201:enzymology*; D051746:ZAP-70 Protein-Tyrosine Kinase / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*
chemical_list: D051746:ZAP-70 Protein-Tyrosine Kinase; C497261:ZAP70 protein, human
keywords: Chronic lymphocytic leukemia; Spleen tyrosine kinase; T-cells; Zeta-Chain Associated Protein Kinase 70kDa