title: Close relationship between serum hyaluronan levels and vascular function in patients with type 2 diabetes.
abstract: OBJECTIVE
  To clarify the relationship between serum hyaluronan levels and vascular function in type 2 diabetic patients.
  
  
  METHODS
  A cross-sectional cohort study.
  
  
  RESULTS
  In multivariate regression analysis, endothelium-dependent flow-mediated dilation was associated with age and duration of diabetes, but not with serum hyaluronan level, while endothelium-independent nitroglycerine-mediated dilation (NMD) was only associated with serum hyaluronan level (standardized estimate = -0.401, p = 0.003). NMD in the lowest tertile of hyaluronan level was significantly higher than the other tertiles (15.9% versus 12.5% and 10.4%, p = 0.047 and p = 0.002, respectively).
  
  
  CONCLUSIONS
  Serum hyaluronan level may be useful as a surrogate marker for early changes in the vascular function, which often occurs in patients with diabetes mellitus.
authors.affiliation: Department of Internal Medicine 1 .
authors.forename: Miwa
authors.initials: M
authors.lastname: Morita
authors.forename: Shozo
authors.initials: S
authors.lastname: Yano
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Ishibashi
authors.forename: Noriko
authors.initials: N
authors.lastname: Nakata
authors.forename: Soichi
authors.initials: S
authors.lastname: Kurioka
authors.forename: Toshitsugu
authors.initials: T
authors.lastname: Sugimoto
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D001916:Brachial Artery / Q000503:physiopathology; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000503:physiopathology; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood*; D008297:Male; D008875:Middle Aged; D014664:Vasodilation
chemical_list: D015415:Biomarkers; D006820:Hyaluronic Acid
keywords: Diabetes; hyaluronan; vascular function