title: Copper-catalyzed three-component cyanotrifluoromethylation/azidotrifluoromethylation and carbocyclization of 1,6-enynes.
abstract: A novel three-component strategy for the cyanotrifluoromethylation/azidotrifluoromethylation and carbocyclization of 1,6-enynes is developed. The reaction proceeds smoothly under a moderate temperature by using a copper catalyst, which provides a rapid and concise access to addition-carbocyclization products. Furthermore, the products obtained can be useful building blocks in discoveries of lead compounds and other biologically active CF3-containing heterocycles.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, P. R. China.
authors.forename: Yu-Tao
authors.initials: YT
authors.lastname: He
authors.forename: Lian-Hua
authors.initials: LH
authors.lastname: Li
authors.forename: Zhao-Zhao
authors.initials: ZZ
authors.lastname: Zhou
authors.forename: Hui-Liang
authors.initials: HL
authors.lastname: Hua
authors.forename: Yi-Feng
authors.initials: YF
authors.lastname: Qiu
authors.forename: Xue-Yuan
authors.initials: XY
authors.lastname: Liu
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Liang