title: Prognostic factors in 151 patients with surgically resected non-functioning pancreatic neuroendocrine tumours.
abstract: BACKGROUND
  Recently, non-functioning pancreatic neuroendocrine tumors (NF-PNETs) are increasing. It is important to know about the prognostic factors and long-term survival rates in patients with NF-PNET for the management of these diseases.
  
  
  METHODS
  We retrospectively analysed the records of 151 patients with NF-PNET who had pancreatic resection between January 1995 and December 2010.
  
  
  RESULTS
  The 10-year overall survival, disease-specific survival and disease-free survival rate of the patients who underwent surgery for NF-PNET were 72.6%, 85.1% and 57.2% respectively. The three staging systems (2004 World Health Organization classification, 2006 European Neuroendocrine Tumor Society stages and 2010 grading system) showed comparable prognostic relevance in disease-specific survival of patients with resected NF-PNETs. Lymph nodes metastasis, high Ki-67 index and mitotic rate were the independent poor prognostic factors for disease-specific survival in the patients with surgically resected NF-PNET on multivariate analysis.
  
  
  CONCLUSIONS
  We suggested that the three staging systems accurately reflect the prognosis in disease-specific survival of patients with resected NF-PNETs. Presence of lymph nodes metastases and high Ki-67 index and mitotic rate were the independent poor prognostic factors after resection of NF-PNET.
authors.affiliation: Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Ulsan University College of Medicine and Asan Medical Center, Seoul, South Korea.
authors.forename: Ki Byung
authors.initials: KB
authors.lastname: Song
authors.affiliation: Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Ulsan University College of Medicine and Asan Medical Center, Seoul, South Korea.
authors.forename: Song Cheol
authors.initials: SC
authors.lastname: Kim
authors.affiliation: Department of Pathology, Ulsan University College of Medicine and Asan Medical Center, Seoul, South Korea.
authors.forename: Ji Hoon
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Pathology, Ulsan University College of Medicine and Asan Medical Center, Seoul, South Korea.
authors.forename: Seung-Mo
authors.initials: SM
authors.lastname: Hong
authors.affiliation: Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Ulsan University College of Medicine and Asan Medical Center, Seoul, South Korea.
authors.forename: Kwang-Min
authors.initials: KM
authors.lastname: Park
authors.affiliation: Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Ulsan University College of Medicine and Asan Medical Center, Seoul, South Korea.
authors.forename: Dae Wook
authors.initials: DW
authors.lastname: Hwang
authors.affiliation: Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Ulsan University College of Medicine and Asan Medical Center, Seoul, South Korea.
authors.forename: Jae Hoon
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Ulsan University College of Medicine and Asan Medical Center, Seoul, South Korea.
authors.forename: Young-Joo
authors.initials: YJ
authors.lastname: Lee
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D018358:Neuroendocrine Tumors / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D011379:Prognosis; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D055815:Young Adult
keywords: classification; disease-specific survivor; non-functioning pancreatic neuroendocrine tumour; prognostic factor; stage