title: 1-Kestose consumption during pregnancy and lactation increases the levels of IgA in the milk of lactating mice.
abstract: To examine the effect of dietary supplementation with 1-kestose on the IgA levels in milk, BALB/c mice were fed diets with or without 5% 1-kestose during pregnancy and lactation. The total and specific IgA levels in the milk were measured at 7 and 14 days after delivery. A two-way ANOVA with repeated measures resulted in a significant effect of 1-kestose-supplementation on total IgA concentrations (p < 0.05) and the level of anti-Bacteroides IgA (p < 0.05). A significant positive correlation was found between the mean count of Bacteroides spp. in maternal feces and the total IgA concentration in maternal milk (r = 0.55, p < 0.05), suggesting a potential link between the gut and mammary gland immune system. In conclusion, this study demonstrated the effects of dietary prebiotics on milk IgA production.
authors.affiliation: a Nutrition Research Department, Food Science Research Laboratories, Division of Research and Development , Meiji Co., Ltd. , Odawara , Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Jinno
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Masashi
authors.initials: M
authors.lastname: Nagata
authors.forename: Takeshi
authors.initials: T
authors.lastname: Takahashi
mesh_terms: D000818:Animals; D001439:Bacteroides / Q000276:immunology / Q000502:physiology; D019587:Dietary Supplements; D005243:Feces / Q000382:microbiology; D005260:Female; D007070:Immunoglobulin A / Q000097:blood / Q000276:immunology / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects / Q000382:microbiology; D007774:Lactation / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D064307:Microbiota / Q000187:drug effects; D008892:Milk / Q000187:drug effects* / Q000378:metabolism*; D011247:Pregnancy; D014312:Trisaccharides / Q000494:pharmacology*
chemical_list: D007070:Immunoglobulin A; D014312:Trisaccharides; C072433:1-kestose
keywords: 1-kestose; Bacteroides spp.; Bifidobacterium spp.; Fructooligosaccharides; IgA