title: [Inherited colorectal cancer predisposition syndromes identified in the Instituto Nacional de Enfermedades Neoplasicas (INEN), Lima, Peru;].
abstract: BACKGROUND
  Colorectal cancer (CRC) is the fourth most common cancer in the world and is classified according to their origin in sporadic CRC (~ 70%) and genetic CRC (~ 30%), this latter involves cases of familial aggregation and inherited síndromes that predispose to CRC.
  
  
  OBJECTIVE
  To describe inherited CRC predisposition syndromes, polyposic and non-polyposic, identified in the Oncogenetics Unit at National Institute of Cancer Disease (INEN).
  
  
  METHODS
  A descriptive observational record from the attentions of the Oncogenetics Unit at INEN during 2009 to 2013. We included patients with personal or familiar history of CRC and/or colonic polyposis who were referred for clinical assessment to the Oncogenetics Unitat INEN.
  
  
  RESULTS
  59.3 % were female, 40.7 % male, 69.8% under 50 years old, 60.5% had a single CRC, 23.2% had more than one CRC or CRC associated with other extracolonic neoplasia and 32.6% had a familiar history of cancer with autosomal dominant inheritance. According to the clinical genetic diagnosis, 93.1% of the included cases were inherited syndromes that predispose to CRC, with 33.8% of colonic polyposis syndromes, 23.3% of hereditary nonpolyposis CRC syndromes (HNPCC) and 36.0% of CCRHNP probable cases.
  
  
  CONCLUSIONS
  Clinical genetic evaluation of patients with personal or familiar history of CRC and/or colonic polyposis can identify inherited colorectal cancer predisposition syndromes and provide an appropriategenetic counseling to patients and relatives at risk, establishing guidelines to follow-up and prevention strategies to prevent morbidity and mortality by cancer.
authors.affiliation: Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú.
authors.forename: María del Carmen
authors.initials: Mdel C
authors.lastname: Castro-Mujica
authors.affiliation: Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú.
authors.forename: Yasser
authors.initials: Y
authors.lastname: Sullcahuamán-Allende
authors.affiliation: Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú.
authors.forename: Fernando
authors.initials: F
authors.lastname: Barreda-Bolaños
authors.affiliation: Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú.
authors.forename: Luis
authors.initials: L
authors.lastname: Taxa-Rojas
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D015179:Colorectal Neoplasms / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D010568:Peru; D013577:Syndrome; D055815:Young Adult