title: In vitro cancer cell growth inhibition and antioxidant activity of Bombax ceiba (Bombacaceae) flower extracts.
abstract: The flowers of Bombax ceiba were investigated for their chemical composition, antioxidant effects and antiproliferative activity against seven human cancer cell lines. The antiproliferative responses of diethyl ether (DE) and light petroleum (PE) extracts were evaluated by sulforhodamine B (SRB) assay against MCF-7, HeLa, COR-L23, C32, A375, ACHN, and LNCaP cells in comparison with a human normal cell line, 142BR. Moreover, extracts were characterized by GC-MS analysis and tested for their antioxidant properties by different in vitro systems, namely DPPH, Fe-chelating activity and beta-carotene bleaching test. Both PE and DE extracts showed the highest antiproliferative activity against human renal adenocarcinoma (ACHN) in a concentration-dependent manner. PE extract showed the highest radical scavenging activity against the DPPH radical, while DE extract was more active in the beta-carotene bleaching test. The presence of beta-sitosterol and some fatty acids may contribute to the bioactivity of B. ceiba flower extracts.
authors.forename: Rosa
authors.initials: R
authors.lastname: Tundis
authors.forename: Khaled
authors.initials: K
authors.lastname: Rashed
authors.forename: Ataa
authors.initials: A
authors.lastname: Said
authors.forename: Francesco
authors.initials: F
authors.lastname: Menichini
authors.forename: Monica R
authors.initials: MR
authors.lastname: Loizzo
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D035163:Bombax / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D035264:Flowers / Q000737:chemistry; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology*; D012855:Sitosterols / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D010936:Plant Extracts; D012855:Sitosterols; C025473:gamma-sitosterol