title: Coniothyren: a new phenoxyphenyl ether from the endophytic fungus, Coniothyrium sp.
abstract: Phytochemical investigation of the endophytic fungus Coniothyrium sp. resulted in the isolation of a new phenoxyphenyl ether, named coniothyren (1), and two known compounds, coniol (2) and (+)-epoxydon (3). The structure of the new compound was elucidated by detailed spectroscopic analysis, namely, (1)H NMR, (13)C NMR, COSY, HMQC, HMBC, and HR-EI-MS. Preliminary studies demonstrated that (+)-epoxydon (3) displayed good antibacterial and antialgal activities toward Bacillus megaterium and Chlorella fusca, respectively.
authors.affiliation: a Department of Chemistry , University of Paderborn , Paderborn 33098 , Germany.
authors.forename: Hidayat
authors.initials: H
authors.lastname: Hussain
authors.forename: Ines
authors.initials: I
authors.lastname: Kock
authors.forename: Ahmed
authors.initials: A
authors.lastname: Al-Harrasi
authors.forename: Ghulam
authors.initials: G
authors.lastname: Abbas
authors.forename: Najeeb Ur
authors.initials: NU
authors.lastname: Rehman
authors.forename: Afzal
authors.initials: A
authors.lastname: Shah
authors.forename: Amin
authors.initials: A
authors.lastname: Badshah
authors.forename: Usman Ali
authors.initials: UA
authors.lastname: Rana
authors.forename: Zakira
authors.initials: Z
authors.lastname: Noureen
authors.forename: Ivan R
authors.initials: IR
authors.lastname: Green
authors.forename: Siegfried
authors.initials: S
authors.lastname: Draeger
authors.forename: Barbara
authors.initials: B
authors.lastname: Schulz
authors.forename: Karsten
authors.initials: K
authors.lastname: Krohn
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D004987:Ethers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010647:Phenyl Ethers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D004987:Ethers; D010647:Phenyl Ethers; C000594272:coniothyren
keywords: Coniothyrium sp; endophytic fungi; natural product