title: Effectiveness of nano-hydroxyapatite toothpaste in reducing dentin hypersensitivity: a double-blind randomized controlled trial.
abstract: OBJECTIVE
  The present double-blind randomized clinical trial aimed to compare the efficacy in reducing dentin hypersensitivity of a dentifrice formulation containing nano-hydroxyapatite with a fluoride dentifrice and a placebo.
  
  
  METHODS
  105 subjects were recruited to participate in the study. A computer-generated random table with blocking to one of the three study treatments was used in order to have 35 subjects per group: 1) nano-hydroxyapatite 15% toothpaste, fluoride-free; 2) fluoride toothpaste; 3) placebo. Groups 1, 2, and 3 were instructed to brush their teeth for 2 minutes twice a day with the provided toothpaste. The participant's dentin hypersensitivity was evaluated at baseline and after 2 and 4 weeks using airblast and tactile tests. In addition, a subjective evaluation using a visual analog scale (VAS) was used.
  
  
  RESULTS
  Significantly lower values of cold air sensitivity and tactile sensitivity (P<.001) were found for the test group at 2 weeks and 4 weeks. In addition, statistically significantly (P<.001) lower values of sensitivity were reported for group 1 compared to groups 2 and 3, at 2 and 4 weeks respectively. The VAS scores were significantly lower (P<.001) in the test group at 2 and 4 weeks compared to baseline and to the control groups.
  
  
  CONCLUSIONS
  The findings of the present study encourage the application of nano-hydroxyapatite in fluoride-free toothpaste as an effective desensitizing agent providing quick relief from symptoms after 2 and 4 weeks.
authors.forename: Michele
authors.initials: M
authors.lastname: Vano
authors.forename: Giacomo
authors.initials: G
authors.lastname: Derchi
authors.forename: Antonio
authors.initials: A
authors.lastname: Barone
authors.forename: Ugo
authors.initials: U
authors.lastname: Covani
mesh_terms: D000328:Adult; D003807:Dentin Sensitivity / Q000628:therapy*; D004311:Double-Blind Method; D017886:Durapatite / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D036103:Nanotechnology; D010919:Placebos; D014100:Toothpastes
chemical_list: D010919:Placebos; D014100:Toothpastes; D017886:Durapatite