title: Recurrent unilateral headache associated with SAPHO syndrome.
abstract: A 57-year-old woman was admitted with recurrent episodes of right frontal headache. Head magnetic resonance imaging (MRI) revealed extensive thickening and enhancement of the right frontal dura, muscle and fascia, as well as abnormal signal intensity and enhancement of bone marrow at the lesions. Synovitis-acne-pustulosis-hyperostosis osteomyelitis (SAPHO) syndrome was diagnosed based on the patient's 8-year history of treatment of palmoplantar pustulosis and abnormal accumulations in the right temporal, sternum, and left medial clavicula on bone scintigraphy. SAPHO syndrome may be associated with skull lesions, which can contribute to the onset of repeated headache or dural thickening, thus these symptoms should be recognized as manifestations of this syndrome.
authors.affiliation: Department of Neurology, Faculty of Medicine, Fukuoka University, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Tsugawa
authors.forename: Shinji
authors.initials: S
authors.lastname: Ouma
authors.forename: Jiro
authors.initials: J
authors.lastname: Fukae
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Tsuboi
mesh_terms: D020083:Acquired Hyperostosis Syndrome / Q000150:complications* / Q000175:diagnosis; D003937:Diagnosis, Differential; D004388:Dura Mater / Q000473:pathology; D005260:Female; D006261:Headache / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged