title: Palladium-catalyzed direct C7-arylation of substituted indazoles.
abstract: A novel direct C7-arylation of indazoles with iodoaryls is described using Pd(OAc)2 as catalyst, 1,10-phenanthroline as ligand, and K2CO3 as base in refluxing DMA. Direct C7-arylation of 3-substituted 1H-indazole containing an EWG on the arene ring gave the expected products in good isolated yields. In addition, a one-pot Suzuki-Miyaura/arylation procedure leading to C3,C7-diarylated indazoles has been developed.
authors.affiliation: Institut de Chimie Organique et Analytique (ICOA), Université d'Orleans UMR CNRS 7311 , BP 6759, 45067 Orléans Cedex 2, France.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Naas
authors.forename: Saïd
authors.initials: S
authors.lastname: El Kazzouli
authors.forename: El Mokhtar
authors.initials: el M
authors.lastname: Essassi
authors.forename: Mosto
authors.initials: M
authors.lastname: Bousmina
authors.forename: Gérald
authors.initials: G
authors.lastname: Guillaumet
mesh_terms: D002384:Catalysis; D007191:Indazoles / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D010618:Phenanthrolines / Q000737:chemistry*
chemical_list: D007191:Indazoles; D008024:Ligands; D010618:Phenanthrolines; D010165:Palladium; C025205:1,10-phenanthroline