title: Inflammatory and oxidative biomarkers of disease severity in dogs with parvoviral enteritis.
abstract: OBJECTIVE
  To study changes in serum C-reactive protein, haptoglobin, ceruloplasmin and albumin concentration, total anti-oxidant capacity and paraoxonase-1 and butyrylcholinesterase activity in dogs with parvoviral enteritis of different degrees of clinical severity.
  
  
  METHODS
  Prospective study of 9 healthy and 43 dogs with parvoviral enteritis that were classified into mildly, moderately and affected groups.
  
  
  RESULTS
  Dogs with parvoviral enteritis had a significant increase in C-reactive protein compared with healthy dogs, with an increase of higher magnitude in animals with more severe clinical signs. All dogs with parvoviral enteritis had a significant increase in haptoglobin concentration compared with healthy dogs, but with no difference according to disease severity. There was a decrease in paraoxonase-1 activity in parvoviral enteritis.
  
  
  CONCLUSIONS
  Major increases of C-reactive protein concentrations in dogs with parvoviral enteritis are a marker of disease severity. In addition, higher values for anti-oxidants in severe cases compared with mild and moderate cases suggest a possible compensatory anti-oxidant mechanism.
authors.affiliation: Department of Internal Medicine, Faculty of Veterinary Medicine, Uludag University, 16190, Bursa, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Kocaturk
authors.forename: A
authors.initials: A
authors.lastname: Tvarijonaviciute
authors.forename: S
authors.initials: S
authors.lastname: Martinez-Subiela
authors.forename: F
authors.initials: F
authors.lastname: Tecles
authors.forename: O
authors.initials: O
authors.lastname: Eralp
authors.forename: Z
authors.initials: Z
authors.lastname: Yilmaz
authors.forename: J J
authors.initials: JJ
authors.lastname: Ceron
mesh_terms: D000818:Animals; D043303:Aryldialkylphosphatase / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D002570:Ceruloplasmin / Q000032:analysis; D004283:Dog Diseases / Q000097:blood* / Q000175:diagnosis; D004285:Dogs / Q000097:blood; D004751:Enteritis / Q000097:blood / Q000175:diagnosis / Q000662:veterinary*; D005260:Female; D006242:Haptoglobins / Q000032:analysis; D007249:Inflammation / Q000097:blood / Q000662:veterinary; D008297:Male; D010084:Oxidation-Reduction; D010322:Parvoviridae Infections / Q000097:blood* / Q000175:diagnosis; D011446:Prospective Studies; D012709:Serum Albumin / Q000032:analysis; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D006242:Haptoglobins; D012709:Serum Albumin; D002097:C-Reactive Protein; D002570:Ceruloplasmin; D043303:Aryldialkylphosphatase