title: [Clinical evaluation of Parkinson's disease progression].
abstract: Objective. We conducted a prospective study on the dynamics of clinical progression of motor and non-motor impairments in PD from 2009 to 2012. Material and methods. We examined 136 patients with Parkinson's disease, 77 men and 59 women, mean age 63.2±10.4 years, disease duration 7.5±3.8 years, including 50 (36.8%) patients at the mild stage of disease, 67 (49.3%) patients at the moderate stage and 19 (13.9%) patients at the advanced stage. Evaluation of progression was carried out annually using part III UPDRS: an annual increase of 9 scores or more indicated the fast progression; from 5 to 8 scores - moderate progression; up to 4 scores - slow progression. Results. Eighty-five patients (62.5%) had slow progression, 39 patients (27.1%) had moderate progression and 12 patients (10.4%) had fast progression. Conclusion. Older age, severity of axial movement disorders, cognitive impairment and motor fluctuations, orthostatic hypotension and psychotic disorders (hallucinations) predicted the fast progression.
authors.affiliation: FGBU "Gosudarstvennyĭ nauchnyĭ tsentr Rossiĭskoĭ Federatsii - Federal'nyĭ meditsinskiĭ biofizicheskiĭ tsentr im. A.I. Burnaziana" FMBA, Moskva.
authors.forename: I G
authors.initials: IG
authors.lastname: Smolentseva
authors.forename: L P
authors.initials: LP
authors.lastname: Chupina
authors.forename: N A
authors.initials: NA
authors.lastname: Amosova
authors.forename: O V
authors.initials: OV
authors.lastname: Krivonos