title: Front-line transplantation program with lenalidomide, bortezomib, and dexamethasone combination as induction and consolidation followed by lenalidomide maintenance in patients with multiple myeloma: a phase II study by the Intergroupe Francophone du Myélome.
abstract: OBJECTIVE
  The three-drug combination of lenalidomide, bortezomib, and dexamethasone (RVD) has shown significant efficacy in multiple myeloma (MM). The Intergroupe Francophone du Myélome (IFM) decided to evaluate RVD induction and consolidation therapies in a sequential intensive strategy for previously untreated transplantation-eligible patients with MM.
  
  
  METHODS
  In this phase II study, 31 symptomatic patients age < 65 years were enrolled to receive three RVD induction cycles followed by cyclophosphamide harvest and transplantation. Patients subsequently received two RVD consolidation cycles and 1-year lenalidomide maintenance.
  
  
  RESULTS
  Very good partial response rate or better at the completion of induction, transplantation, and consolidation therapy was 58%, 70%, and 87%, respectively. Maintenance upgraded responses in 27% of patients. Overall, 58% of patients achieved complete response, and 68% were minimal residual disease (MRD) negative by flow cytometry. The most common toxicities with RVD were neurologic and hematologic, including grade 1 to 2 sensory neuropathy (55%), grade 3 to 4 neutropenia (35%), and thrombocytopenia (13%). Two basal cell carcinomas in the same patient and one case of breast cancer were observed. There was no treatment-related mortality. With a median follow-up of 39 months, estimated 3-year progression-free and overall survival were 77% and 100%, respectively. None of the patients who achieved MRD negativity relapsed.
  
  
  CONCLUSIONS
  The transplantation program with RVD induction and consolidation followed by lenalidomide maintenance produced high-quality responses and showed favorable tolerability in patients with newly diagnosed MM. Overall, 68% of patients achieved MRD negativity; none of these patients relapsed. This program is being evaluated in the ongoing IFM/Dana-Farber Cancer Institute 2009 phase III study.
authors.affiliation: Murielle Roussel, Valérie Lauwers-Cances, Catherine Gentil, Anne Huynh, Benjamin Hebraud, Jill Corre, and Hervé Avet-Loiseau, Hopitaux de Toulouse; Michel Attal, Institut Claudius Regaud, Toulouse; Nelly Robillard, Philippe Moreau, and Soraya Wuilleme, Hôtel Dieu, Nantes; Cyrille Hulin, Centre Hospitalier Brabois, Nancy; Xavier Leleu and Thierry Facon, Hôpital Claude Huriez, Lille; Lotfi Benboubker, Hôpital Bretonneau, Tours; Gérald Marit, Hôpital Haut-Lévêque, Bordeaux Pessac; Brigitte Pegourie, Hôpital Albert Michallon, Grenoble; Denis Caillot and Marie-Lorraine Chretien, Centre Hospitalier Le Bocage, Dijon; Christophe Fruchart, Centre François Baclesse, Caen; and Anne-Marie Stoppa, Institut Paoli Calmettes, Marseille, France. roussel.m@chu-toulouse.fr.
authors.forename: Murielle
authors.initials: M
authors.lastname: Roussel
authors.affiliation: Murielle Roussel, Valérie Lauwers-Cances, Catherine Gentil, Anne Huynh, Benjamin Hebraud, Jill Corre, and Hervé Avet-Loiseau, Hopitaux de Toulouse; Michel Attal, Institut Claudius Regaud, Toulouse; Nelly Robillard, Philippe Moreau, and Soraya Wuilleme, Hôtel Dieu, Nantes; Cyrille Hulin, Centre Hospitalier Brabois, Nancy; Xavier Leleu and Thierry Facon, Hôpital Claude Huriez, Lille; Lotfi Benboubker, Hôpital Bretonneau, Tours; Gérald Marit, Hôpital Haut-Lévêque, Bordeaux Pessac; Brigitte Pegourie, Hôpital Albert Michallon, Grenoble; Denis Caillot and Marie-Lorraine Chretien, Centre Hospitalier Le Bocage, Dijon; Christophe Fruchart, Centre François Baclesse, Caen; and Anne-Marie Stoppa, Institut Paoli Calmettes, Marseille, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Lauwers-Cances
authors.affiliation: Murielle Roussel, Valérie Lauwers-Cances, Catherine Gentil, Anne Huynh, Benjamin Hebraud, Jill Corre, and Hervé Avet-Loiseau, Hopitaux de Toulouse; Michel Attal, Institut Claudius Regaud, Toulouse; Nelly Robillard, Philippe Moreau, and Soraya Wuilleme, Hôtel Dieu, Nantes; Cyrille Hulin, Centre Hospitalier Brabois, Nancy; Xavier Leleu and Thierry Facon, Hôpital Claude Huriez, Lille; Lotfi Benboubker, Hôpital Bretonneau, Tours; Gérald Marit, Hôpital Haut-Lévêque, Bordeaux Pessac; Brigitte Pegourie, Hôpital Albert Michallon, Grenoble; Denis Caillot and Marie-Lorraine Chretien, Centre Hospitalier Le Bocage, Dijon; Christophe Fruchart, Centre François Baclesse, Caen; and Anne-Marie Stoppa, Institut Paoli Calmettes, Marseille, France.
authors.forename: Nelly
authors.initials: N
authors.lastname: Robillard
authors.affiliation: Murielle Roussel, Valérie Lauwers-Cances, Catherine Gentil, Anne Huynh, Benjamin Hebraud, Jill Corre, and Hervé Avet-Loiseau, Hopitaux de Toulouse; Michel Attal, Institut Claudius Regaud, Toulouse; Nelly Robillard, Philippe Moreau, and Soraya Wuilleme, Hôtel Dieu, Nantes; Cyrille Hulin, Centre Hospitalier Brabois, Nancy; Xavier Leleu and Thierry Facon, Hôpital Claude Huriez, Lille; Lotfi Benboubker, Hôpital Bretonneau, Tours; Gérald Marit, Hôpital Haut-Lévêque, Bordeaux Pessac; Brigitte Pegourie, Hôpital Albert Michallon, Grenoble; Denis Caillot and Marie-Lorraine Chretien, Centre Hospitalier Le Bocage, Dijon; Christophe Fruchart, Centre François Baclesse, Caen; and Anne-Marie Stoppa, Institut Paoli Calmettes, Marseille, France.
authors.forename: Cyrille
authors.initials: C
authors.lastname: Hulin
authors.affiliation: Murielle Roussel, Valérie Lauwers-Cances, Catherine Gentil, Anne Huynh, Benjamin Hebraud, Jill Corre, and Hervé Avet-Loiseau, Hopitaux de Toulouse; Michel Attal, Institut Claudius Regaud, Toulouse; Nelly Robillard, Philippe Moreau, and Soraya Wuilleme, Hôtel Dieu, Nantes; Cyrille Hulin, Centre Hospitalier Brabois, Nancy; Xavier Leleu and Thierry Facon, Hôpital Claude Huriez, Lille; Lotfi Benboubker, Hôpital Bretonneau, Tours; Gérald Marit, Hôpital Haut-Lévêque, Bordeaux Pessac; Brigitte Pegourie, Hôpital Albert Michallon, Grenoble; Denis Caillot and Marie-Lorraine Chretien, Centre Hospitalier Le Bocage, Dijon; Christophe Fruchart, Centre François Baclesse, Caen; and Anne-Marie Stoppa, Institut Paoli Calmettes, Marseille, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Leleu
authors.affiliation: Murielle Roussel, Valérie Lauwers-Cances, Catherine Gentil, Anne Huynh, Benjamin Hebraud, Jill Corre, and Hervé Avet-Loiseau, Hopitaux de Toulouse; Michel Attal, Institut Claudius Regaud, Toulouse; Nelly Robillard, Philippe Moreau, and Soraya Wuilleme, Hôtel Dieu, Nantes; Cyrille Hulin, Centre Hospitalier Brabois, Nancy; Xavier Leleu and Thierry Facon, Hôpital Claude Huriez, Lille; Lotfi Benboubker, Hôpital Bretonneau, Tours; Gérald Marit, Hôpital Haut-Lévêque, Bordeaux Pessac; Brigitte Pegourie, Hôpital Albert Michallon, Grenoble; Denis Caillot and Marie-Lorraine Chretien, Centre Hospitalier Le Bocage, Dijon; Christophe Fruchart, Centre François Baclesse, Caen; and Anne-Marie Stoppa, Institut Paoli Calmettes, Marseille, France.
authors.forename: Lotfi
authors.initials: L
authors.lastname: Benboubker
authors.affiliation: Murielle Roussel, Valérie Lauwers-Cances, Catherine Gentil, Anne Huynh, Benjamin Hebraud, Jill Corre, and Hervé Avet-Loiseau, Hopitaux de Toulouse; Michel Attal, Institut Claudius Regaud, Toulouse; Nelly Robillard, Philippe Moreau, and Soraya Wuilleme, Hôtel Dieu, Nantes; Cyrille Hulin, Centre Hospitalier Brabois, Nancy; Xavier Leleu and Thierry Facon, Hôpital Claude Huriez, Lille; Lotfi Benboubker, Hôpital Bretonneau, Tours; Gérald Marit, Hôpital Haut-Lévêque, Bordeaux Pessac; Brigitte Pegourie, Hôpital Albert Michallon, Grenoble; Denis Caillot and Marie-Lorraine Chretien, Centre Hospitalier Le Bocage, Dijon; Christophe Fruchart, Centre François Baclesse, Caen; and Anne-Marie Stoppa, Institut Paoli Calmettes, Marseille, France.
authors.forename: Gérald
authors.initials: G
authors.lastname: Marit
authors.affiliation: Murielle Roussel, Valérie Lauwers-Cances, Catherine Gentil, Anne Huynh, Benjamin Hebraud, Jill Corre, and Hervé Avet-Loiseau, Hopitaux de Toulouse; Michel Attal, Institut Claudius Regaud, Toulouse; Nelly Robillard, Philippe Moreau, and Soraya Wuilleme, Hôtel Dieu, Nantes; Cyrille Hulin, Centre Hospitalier Brabois, Nancy; Xavier Leleu and Thierry Facon, Hôpital Claude Huriez, Lille; Lotfi Benboubker, Hôpital Bretonneau, Tours; Gérald Marit, Hôpital Haut-Lévêque, Bordeaux Pessac; Brigitte Pegourie, Hôpital Albert Michallon, Grenoble; Denis Caillot and Marie-Lorraine Chretien, Centre Hospitalier Le Bocage, Dijon; Christophe Fruchart, Centre François Baclesse, Caen; and Anne-Marie Stoppa, Institut Paoli Calmettes, Marseille, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Moreau
authors.affiliation: Murielle Roussel, Valérie Lauwers-Cances, Catherine Gentil, Anne Huynh, Benjamin Hebraud, Jill Corre, and Hervé Avet-Loiseau, Hopitaux de Toulouse; Michel Attal, Institut Claudius Regaud, Toulouse; Nelly Robillard, Philippe Moreau, and Soraya Wuilleme, Hôtel Dieu, Nantes; Cyrille Hulin, Centre Hospitalier Brabois, Nancy; Xavier Leleu and Thierry Facon, Hôpital Claude Huriez, Lille; Lotfi Benboubker, Hôpital Bretonneau, Tours; Gérald Marit, Hôpital Haut-Lévêque, Bordeaux Pessac; Brigitte Pegourie, Hôpital Albert Michallon, Grenoble; Denis Caillot and Marie-Lorraine Chretien, Centre Hospitalier Le Bocage, Dijon; Christophe Fruchart, Centre François Baclesse, Caen; and Anne-Marie Stoppa, Institut Paoli Calmettes, Marseille, France.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Pegourie
authors.affiliation: Murielle Roussel, Valérie Lauwers-Cances, Catherine Gentil, Anne Huynh, Benjamin Hebraud, Jill Corre, and Hervé Avet-Loiseau, Hopitaux de Toulouse; Michel Attal, Institut Claudius Regaud, Toulouse; Nelly Robillard, Philippe Moreau, and Soraya Wuilleme, Hôtel Dieu, Nantes; Cyrille Hulin, Centre Hospitalier Brabois, Nancy; Xavier Leleu and Thierry Facon, Hôpital Claude Huriez, Lille; Lotfi Benboubker, Hôpital Bretonneau, Tours; Gérald Marit, Hôpital Haut-Lévêque, Bordeaux Pessac; Brigitte Pegourie, Hôpital Albert Michallon, Grenoble; Denis Caillot and Marie-Lorraine Chretien, Centre Hospitalier Le Bocage, Dijon; Christophe Fruchart, Centre François Baclesse, Caen; and Anne-Marie Stoppa, Institut Paoli Calmettes, Marseille, France.
authors.forename: Denis
authors.initials: D
authors.lastname: Caillot
authors.affiliation: Murielle Roussel, Valérie Lauwers-Cances, Catherine Gentil, Anne Huynh, Benjamin Hebraud, Jill Corre, and Hervé Avet-Loiseau, Hopitaux de Toulouse; Michel Attal, Institut Claudius Regaud, Toulouse; Nelly Robillard, Philippe Moreau, and Soraya Wuilleme, Hôtel Dieu, Nantes; Cyrille Hulin, Centre Hospitalier Brabois, Nancy; Xavier Leleu and Thierry Facon, Hôpital Claude Huriez, Lille; Lotfi Benboubker, Hôpital Bretonneau, Tours; Gérald Marit, Hôpital Haut-Lévêque, Bordeaux Pessac; Brigitte Pegourie, Hôpital Albert Michallon, Grenoble; Denis Caillot and Marie-Lorraine Chretien, Centre Hospitalier Le Bocage, Dijon; Christophe Fruchart, Centre François Baclesse, Caen; and Anne-Marie Stoppa, Institut Paoli Calmettes, Marseille, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Fruchart
authors.affiliation: Murielle Roussel, Valérie Lauwers-Cances, Catherine Gentil, Anne Huynh, Benjamin Hebraud, Jill Corre, and Hervé Avet-Loiseau, Hopitaux de Toulouse; Michel Attal, Institut Claudius Regaud, Toulouse; Nelly Robillard, Philippe Moreau, and Soraya Wuilleme, Hôtel Dieu, Nantes; Cyrille Hulin, Centre Hospitalier Brabois, Nancy; Xavier Leleu and Thierry Facon, Hôpital Claude Huriez, Lille; Lotfi Benboubker, Hôpital Bretonneau, Tours; Gérald Marit, Hôpital Haut-Lévêque, Bordeaux Pessac; Brigitte Pegourie, Hôpital Albert Michallon, Grenoble; Denis Caillot and Marie-Lorraine Chretien, Centre Hospitalier Le Bocage, Dijon; Christophe Fruchart, Centre François Baclesse, Caen; and Anne-Marie Stoppa, Institut Paoli Calmettes, Marseille, France.
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Stoppa
authors.affiliation: Murielle Roussel, Valérie Lauwers-Cances, Catherine Gentil, Anne Huynh, Benjamin Hebraud, Jill Corre, and Hervé Avet-Loiseau, Hopitaux de Toulouse; Michel Attal, Institut Claudius Regaud, Toulouse; Nelly Robillard, Philippe Moreau, and Soraya Wuilleme, Hôtel Dieu, Nantes; Cyrille Hulin, Centre Hospitalier Brabois, Nancy; Xavier Leleu and Thierry Facon, Hôpital Claude Huriez, Lille; Lotfi Benboubker, Hôpital Bretonneau, Tours; Gérald Marit, Hôpital Haut-Lévêque, Bordeaux Pessac; Brigitte Pegourie, Hôpital Albert Michallon, Grenoble; Denis Caillot and Marie-Lorraine Chretien, Centre Hospitalier Le Bocage, Dijon; Christophe Fruchart, Centre François Baclesse, Caen; and Anne-Marie Stoppa, Institut Paoli Calmettes, Marseille, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Gentil
authors.affiliation: Murielle Roussel, Valérie Lauwers-Cances, Catherine Gentil, Anne Huynh, Benjamin Hebraud, Jill Corre, and Hervé Avet-Loiseau, Hopitaux de Toulouse; Michel Attal, Institut Claudius Regaud, Toulouse; Nelly Robillard, Philippe Moreau, and Soraya Wuilleme, Hôtel Dieu, Nantes; Cyrille Hulin, Centre Hospitalier Brabois, Nancy; Xavier Leleu and Thierry Facon, Hôpital Claude Huriez, Lille; Lotfi Benboubker, Hôpital Bretonneau, Tours; Gérald Marit, Hôpital Haut-Lévêque, Bordeaux Pessac; Brigitte Pegourie, Hôpital Albert Michallon, Grenoble; Denis Caillot and Marie-Lorraine Chretien, Centre Hospitalier Le Bocage, Dijon; Christophe Fruchart, Centre François Baclesse, Caen; and Anne-Marie Stoppa, Institut Paoli Calmettes, Marseille, France.
authors.forename: Soraya
authors.initials: S
authors.lastname: Wuilleme
authors.affiliation: Murielle Roussel, Valérie Lauwers-Cances, Catherine Gentil, Anne Huynh, Benjamin Hebraud, Jill Corre, and Hervé Avet-Loiseau, Hopitaux de Toulouse; Michel Attal, Institut Claudius Regaud, Toulouse; Nelly Robillard, Philippe Moreau, and Soraya Wuilleme, Hôtel Dieu, Nantes; Cyrille Hulin, Centre Hospitalier Brabois, Nancy; Xavier Leleu and Thierry Facon, Hôpital Claude Huriez, Lille; Lotfi Benboubker, Hôpital Bretonneau, Tours; Gérald Marit, Hôpital Haut-Lévêque, Bordeaux Pessac; Brigitte Pegourie, Hôpital Albert Michallon, Grenoble; Denis Caillot and Marie-Lorraine Chretien, Centre Hospitalier Le Bocage, Dijon; Christophe Fruchart, Centre François Baclesse, Caen; and Anne-Marie Stoppa, Institut Paoli Calmettes, Marseille, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Huynh
authors.affiliation: Murielle Roussel, Valérie Lauwers-Cances, Catherine Gentil, Anne Huynh, Benjamin Hebraud, Jill Corre, and Hervé Avet-Loiseau, Hopitaux de Toulouse; Michel Attal, Institut Claudius Regaud, Toulouse; Nelly Robillard, Philippe Moreau, and Soraya Wuilleme, Hôtel Dieu, Nantes; Cyrille Hulin, Centre Hospitalier Brabois, Nancy; Xavier Leleu and Thierry Facon, Hôpital Claude Huriez, Lille; Lotfi Benboubker, Hôpital Bretonneau, Tours; Gérald Marit, Hôpital Haut-Lévêque, Bordeaux Pessac; Brigitte Pegourie, Hôpital Albert Michallon, Grenoble; Denis Caillot and Marie-Lorraine Chretien, Centre Hospitalier Le Bocage, Dijon; Christophe Fruchart, Centre François Baclesse, Caen; and Anne-Marie Stoppa, Institut Paoli Calmettes, Marseille, France.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Hebraud
authors.affiliation: Murielle Roussel, Valérie Lauwers-Cances, Catherine Gentil, Anne Huynh, Benjamin Hebraud, Jill Corre, and Hervé Avet-Loiseau, Hopitaux de Toulouse; Michel Attal, Institut Claudius Regaud, Toulouse; Nelly Robillard, Philippe Moreau, and Soraya Wuilleme, Hôtel Dieu, Nantes; Cyrille Hulin, Centre Hospitalier Brabois, Nancy; Xavier Leleu and Thierry Facon, Hôpital Claude Huriez, Lille; Lotfi Benboubker, Hôpital Bretonneau, Tours; Gérald Marit, Hôpital Haut-Lévêque, Bordeaux Pessac; Brigitte Pegourie, Hôpital Albert Michallon, Grenoble; Denis Caillot and Marie-Lorraine Chretien, Centre Hospitalier Le Bocage, Dijon; Christophe Fruchart, Centre François Baclesse, Caen; and Anne-Marie Stoppa, Institut Paoli Calmettes, Marseille, France.
authors.forename: Jill
authors.initials: J
authors.lastname: Corre
authors.affiliation: Murielle Roussel, Valérie Lauwers-Cances, Catherine Gentil, Anne Huynh, Benjamin Hebraud, Jill Corre, and Hervé Avet-Loiseau, Hopitaux de Toulouse; Michel Attal, Institut Claudius Regaud, Toulouse; Nelly Robillard, Philippe Moreau, and Soraya Wuilleme, Hôtel Dieu, Nantes; Cyrille Hulin, Centre Hospitalier Brabois, Nancy; Xavier Leleu and Thierry Facon, Hôpital Claude Huriez, Lille; Lotfi Benboubker, Hôpital Bretonneau, Tours; Gérald Marit, Hôpital Haut-Lévêque, Bordeaux Pessac; Brigitte Pegourie, Hôpital Albert Michallon, Grenoble; Denis Caillot and Marie-Lorraine Chretien, Centre Hospitalier Le Bocage, Dijon; Christophe Fruchart, Centre François Baclesse, Caen; and Anne-Marie Stoppa, Institut Paoli Calmettes, Marseille, France.
authors.forename: Marie-Lorraine
authors.initials: ML
authors.lastname: Chretien
authors.affiliation: Murielle Roussel, Valérie Lauwers-Cances, Catherine Gentil, Anne Huynh, Benjamin Hebraud, Jill Corre, and Hervé Avet-Loiseau, Hopitaux de Toulouse; Michel Attal, Institut Claudius Regaud, Toulouse; Nelly Robillard, Philippe Moreau, and Soraya Wuilleme, Hôtel Dieu, Nantes; Cyrille Hulin, Centre Hospitalier Brabois, Nancy; Xavier Leleu and Thierry Facon, Hôpital Claude Huriez, Lille; Lotfi Benboubker, Hôpital Bretonneau, Tours; Gérald Marit, Hôpital Haut-Lévêque, Bordeaux Pessac; Brigitte Pegourie, Hôpital Albert Michallon, Grenoble; Denis Caillot and Marie-Lorraine Chretien, Centre Hospitalier Le Bocage, Dijon; Christophe Fruchart, Centre François Baclesse, Caen; and Anne-Marie Stoppa, Institut Paoli Calmettes, Marseille, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Facon
authors.affiliation: Murielle Roussel, Valérie Lauwers-Cances, Catherine Gentil, Anne Huynh, Benjamin Hebraud, Jill Corre, and Hervé Avet-Loiseau, Hopitaux de Toulouse; Michel Attal, Institut Claudius Regaud, Toulouse; Nelly Robillard, Philippe Moreau, and Soraya Wuilleme, Hôtel Dieu, Nantes; Cyrille Hulin, Centre Hospitalier Brabois, Nancy; Xavier Leleu and Thierry Facon, Hôpital Claude Huriez, Lille; Lotfi Benboubker, Hôpital Bretonneau, Tours; Gérald Marit, Hôpital Haut-Lévêque, Bordeaux Pessac; Brigitte Pegourie, Hôpital Albert Michallon, Grenoble; Denis Caillot and Marie-Lorraine Chretien, Centre Hospitalier Le Bocage, Dijon; Christophe Fruchart, Centre François Baclesse, Caen; and Anne-Marie Stoppa, Institut Paoli Calmettes, Marseille, France.
authors.forename: Hervé
authors.initials: H
authors.lastname: Avet-Loiseau
authors.affiliation: Murielle Roussel, Valérie Lauwers-Cances, Catherine Gentil, Anne Huynh, Benjamin Hebraud, Jill Corre, and Hervé Avet-Loiseau, Hopitaux de Toulouse; Michel Attal, Institut Claudius Regaud, Toulouse; Nelly Robillard, Philippe Moreau, and Soraya Wuilleme, Hôtel Dieu, Nantes; Cyrille Hulin, Centre Hospitalier Brabois, Nancy; Xavier Leleu and Thierry Facon, Hôpital Claude Huriez, Lille; Lotfi Benboubker, Hôpital Bretonneau, Tours; Gérald Marit, Hôpital Haut-Lévêque, Bordeaux Pessac; Brigitte Pegourie, Hôpital Albert Michallon, Grenoble; Denis Caillot and Marie-Lorraine Chretien, Centre Hospitalier Le Bocage, Dijon; Christophe Fruchart, Centre François Baclesse, Caen; and Anne-Marie Stoppa, Institut Paoli Calmettes, Marseille, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Attal
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001897:Boronic Acids / Q000008:administration & dosage; D000069286:Bortezomib; D003131:Combined Modality Therapy; D060830:Consolidation Chemotherapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D003907:Dexamethasone / Q000008:administration & dosage; D005260:Female; D005602:France; D006801:Humans; D000077269:Lenalidomide; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy / Q000628:therapy*; D011719:Pyrazines / Q000008:administration & dosage; D012074:Remission Induction; D033581:Stem Cell Transplantation / Q000379:methods*; D013792:Thalidomide / Q000008:administration & dosage / Q000031:analogs & derivatives; D014182:Transplantation, Autologous
chemical_list: D001897:Boronic Acids; D011719:Pyrazines; D013792:Thalidomide; D000069286:Bortezomib; D003907:Dexamethasone; D003520:Cyclophosphamide; D000077269:Lenalidomide