title: [Polymorphism of gene of ІL-8 (А-251T) in patients with acute pancreatitis].
abstract: The research aims to investigate the IL-8 А-251Т (rs 4073) gene polymorphism in patients with acute pancreatitis. The frequency of allelic variants of cytokine gene in 100 patients was determined. Genotype А/Т was found in 47.0% of cases (47 patients) of acute pancreatitis, T/T alleles - in 37% of cases (37 patients), A/A alleles in 16% of cases (16 patients). In 73.3% of non-operated patients with destructive forms of acute pancreatitis the reliable (р<0,05) increase of heterozygous carriers of genotype А/Т were detected. In patients with edematous form of acute pancreatitis frequency of А/Т was detected in 42.2% of cases, In control group frequency of А/Т was detected in 46% of cases, The possible association between genotype А/Т and the destruction of the pancreas was determined.
authors.forename: V A
authors.initials: VA
authors.lastname: Chantsev
authors.forename: V V
authors.initials: VV
authors.lastname: Leonov
mesh_terms: D000483:Alleles; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016209:Interleukin-8 / Q000235:genetics*; D008297:Male; D010195:Pancreatitis / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide
chemical_list: C508606:CXCL8 protein, human; D016209:Interleukin-8