title: Efficient total synthesis of bioactive natural products: a personal record.
abstract: In this account, we have highlighted our most recent works towards the total synthesis of bioactive natural products, which have resulted in the development of several novel synthetic methods. Inspired and guided by strategies based on diversity-oriented synthesis, we have successfully applied the novel synthetic methodologies developed in our lab to the total synthesis of a diverse collection of structurally challenging targets. We have also documented the evolution of these synthetic strategies. The total syntheses described in this account have been organized from the perspective of different molecules whilst still alluding to the parallel synthetic strategies involved.
authors.affiliation: Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, P. R. China. gongjx@pku.edu.cn.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jianxian
authors.initials: J
authors.lastname: Gong
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yang
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic / Q000191:economics / Q000379:methods*; D061565:Cycloaddition Reaction / Q000191:economics / Q000379:methods; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000138:chemical synthesis / Q000737:chemistry; D013256:Steroids / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D001688:Biological Products; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; D013256:Steroids; C506145:cladiellin A; C437376:drimane
keywords: Diels-Alder reactions; Pauson-Khand reactions; natural products; synthetic methods; total synthesis