title: Hypoadiponectinemia correlates with arterial stiffness in kidney transplantation patients.
abstract: BACKGROUND
  Adiponectin is a fat-derived hormone produced and secreted exclusively by adipocytes that have anti-atherosclerotic effects. The aim of this study was to evaluate the relationship between fasting serum adiponectin levels and arterial stiffness among kidney transplant (KT) patients.
  
  
  METHODS
  Fasting blood samples were obtained from 69 KT patients. Brachial-ankle pulse wave velocity (baPWV) was measured in the right or left brachial artery to the ankle segments using an automatic pulse wave analyzer. Plasma adiponectin levels were measured using a commercial enzyme-linked immunosorbent assay kit. Left or right baPWV values of >14.0 m/s were used to define the high arterial stiffness group.
  
  
  RESULTS
  Thirty-five KT patients (35/69; 50.7 %) were defined in high arterial stiffness group. Diabetes (P = 0.013), smoking (P = 0.001), KT duration (P < 0.001), body weight (P = 0.013), waist circumference (P = 0.013), body mass index (P = 0.001), fasting glucose (P = 0.013), systolic blood pressure (P < 0.001), diastolic blood pressure (P = 0.008), and pulse pressure (P = 0.003) were higher, while serum adiponectin level (P = 0.004) was lower in high arterial stiffness group compared with low arterial stiffness group. Multivariate logistic regression analysis showed that adiponectin (odds ratio 0.90, 95 % confidence interval 0.81-0.99, P = 0.034) was still the independent predictors of arterial stiffness among the KT patients.
  
  
  CONCLUSIONS
  Serum fasting adiponectin level was inversely associated with arterial stiffness among KT patients.
authors.affiliation: Department of Surgery, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
authors.forename: Guan-Jin
authors.initials: GJ
authors.lastname: Ho
authors.affiliation: Department of Surgery, Buddhist Tzu Chi General Hospital, and School of Medicine, Tzu Chi University, Hualien, Taiwan.
authors.forename: Ming-Che
authors.initials: MC
authors.lastname: Lee
authors.affiliation: Department of Nursing, Tzu Chi College of Technology, Hualien, Taiwan.
authors.forename: Chung-Jen
authors.initials: CJ
authors.lastname: Lee
authors.affiliation: Department of Surgery, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
authors.forename: Yen-Cheng
authors.initials: YC
authors.lastname: Chen
authors.affiliation: Division of Nephrology, Buddhist Tzu Chi General Hospital, and School of Medicine, Tzu Chi University, No. 707, Section 3, Chung-Yang Raod, Hualien, Taiwan. gee.lily@msa.hinet.net.
authors.forename: Bang-Gee
authors.initials: BG
authors.lastname: Hsu
mesh_terms: D052242:Adiponectin / Q000097:blood* / Q000172:deficiency*; D000328:Adult; D000368:Aged; D005215:Fasting; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008661:Metabolism, Inborn Errors / Q000503:physiopathology*; D008875:Middle Aged; D063177:Pulse Wave Analysis; D059289:Vascular Stiffness
chemical_list: D052242:Adiponectin
keywords: Adiponectin; Arterial stiffness; Brachial–ankle pulse wave velocity; Kidney transplantation