title: Convulsive status epilepticus and health-related quality of life in children with epilepsy.
abstract: OBJECTIVE
  The objective of this study was to examine the association between convulsive status epilepticus (CSE) and health-related quality of life (HRQL) during a 24-month follow-up in a multisite incident cohort of children with epilepsy.
  
  
  METHODS
  Data were collected in the Health-Related Quality of Life Study in Children with Epilepsy Study from 374 families of children with newly diagnosed epilepsy. The Quality of Life in Childhood Epilepsy (QOLCE) Questionnaire was used to evaluate parent-reported child HRQL. Hierarchical linear regression was used to examine the relationship between CSE and HRQL at 24 months postepilepsy. A total of 359 families completed the 24-month assessment.
  
  
  RESULTS
  Twenty-two children (6.1%) had experienced CSE during the follow-up. Children with and without CSE were similar, except a larger proportion of children with CSE had partial seizures (p < 0.001). Controlling for clinical, demographic, and family characteristics, CSE was significantly associated with poorer HRQL (β = -4.65, p = 0.031). The final model explained 47% of the variance in QOLCE scores.
  
  
  CONCLUSIONS
  The findings suggested that not only do children with CSE have significantly poorer HRQL compared with their non-CSE counterparts, but that this factor is independent of the effects of demographic and clinical features known to affect HRQL.
authors.affiliation: From the Departments of Psychiatry & Behavioural Neurosciences (M.A.F.) and Pediatrics (M.A.F.), Offord Centre for Child Studies (M.A.F.), and CanChild Centre for Child Disability Research (M.A.F.), McMaster University, Hamilton, Canada; Muir Maxwell Epilepsy Centre (R.F.M.C.), The University of Edinburgh; Paediatric Neurosciences (R.F.M.C.), Royal Hospital for Sick Children (Edinburgh), UK; Child Neurology (C.S.C.), IWK Health Centre, Department of Paediatrics, Dalhousie University, Halifax; Department of Clinical Neuroscience (S.W.), University of Calgary; Departments of Paediatrics (S.D.L., K.N.S.) and Epidemiology & Biostatistics (K.N.S.), Western University, London, ON; and Children's Health Research Institute (S.D.L., K.N.S.), Lawson Health Research Institute, London, ON, Canada. ferroma@mcmaster.ca.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Ferro
authors.affiliation: From the Departments of Psychiatry & Behavioural Neurosciences (M.A.F.) and Pediatrics (M.A.F.), Offord Centre for Child Studies (M.A.F.), and CanChild Centre for Child Disability Research (M.A.F.), McMaster University, Hamilton, Canada; Muir Maxwell Epilepsy Centre (R.F.M.C.), The University of Edinburgh; Paediatric Neurosciences (R.F.M.C.), Royal Hospital for Sick Children (Edinburgh), UK; Child Neurology (C.S.C.), IWK Health Centre, Department of Paediatrics, Dalhousie University, Halifax; Department of Clinical Neuroscience (S.W.), University of Calgary; Departments of Paediatrics (S.D.L., K.N.S.) and Epidemiology & Biostatistics (K.N.S.), Western University, London, ON; and Children's Health Research Institute (S.D.L., K.N.S.), Lawson Health Research Institute, London, ON, Canada.
authors.forename: Richard F M
authors.initials: RF
authors.lastname: Chin
authors.affiliation: From the Departments of Psychiatry & Behavioural Neurosciences (M.A.F.) and Pediatrics (M.A.F.), Offord Centre for Child Studies (M.A.F.), and CanChild Centre for Child Disability Research (M.A.F.), McMaster University, Hamilton, Canada; Muir Maxwell Epilepsy Centre (R.F.M.C.), The University of Edinburgh; Paediatric Neurosciences (R.F.M.C.), Royal Hospital for Sick Children (Edinburgh), UK; Child Neurology (C.S.C.), IWK Health Centre, Department of Paediatrics, Dalhousie University, Halifax; Department of Clinical Neuroscience (S.W.), University of Calgary; Departments of Paediatrics (S.D.L., K.N.S.) and Epidemiology & Biostatistics (K.N.S.), Western University, London, ON; and Children's Health Research Institute (S.D.L., K.N.S.), Lawson Health Research Institute, London, ON, Canada.
authors.forename: Carol S
authors.initials: CS
authors.lastname: Camfield
authors.affiliation: From the Departments of Psychiatry & Behavioural Neurosciences (M.A.F.) and Pediatrics (M.A.F.), Offord Centre for Child Studies (M.A.F.), and CanChild Centre for Child Disability Research (M.A.F.), McMaster University, Hamilton, Canada; Muir Maxwell Epilepsy Centre (R.F.M.C.), The University of Edinburgh; Paediatric Neurosciences (R.F.M.C.), Royal Hospital for Sick Children (Edinburgh), UK; Child Neurology (C.S.C.), IWK Health Centre, Department of Paediatrics, Dalhousie University, Halifax; Department of Clinical Neuroscience (S.W.), University of Calgary; Departments of Paediatrics (S.D.L., K.N.S.) and Epidemiology & Biostatistics (K.N.S.), Western University, London, ON; and Children's Health Research Institute (S.D.L., K.N.S.), Lawson Health Research Institute, London, ON, Canada.
authors.forename: Samuel
authors.initials: S
authors.lastname: Wiebe
authors.affiliation: From the Departments of Psychiatry & Behavioural Neurosciences (M.A.F.) and Pediatrics (M.A.F.), Offord Centre for Child Studies (M.A.F.), and CanChild Centre for Child Disability Research (M.A.F.), McMaster University, Hamilton, Canada; Muir Maxwell Epilepsy Centre (R.F.M.C.), The University of Edinburgh; Paediatric Neurosciences (R.F.M.C.), Royal Hospital for Sick Children (Edinburgh), UK; Child Neurology (C.S.C.), IWK Health Centre, Department of Paediatrics, Dalhousie University, Halifax; Department of Clinical Neuroscience (S.W.), University of Calgary; Departments of Paediatrics (S.D.L., K.N.S.) and Epidemiology & Biostatistics (K.N.S.), Western University, London, ON; and Children's Health Research Institute (S.D.L., K.N.S.), Lawson Health Research Institute, London, ON, Canada.
authors.forename: Simon D
authors.initials: SD
authors.lastname: Levin
authors.affiliation: From the Departments of Psychiatry & Behavioural Neurosciences (M.A.F.) and Pediatrics (M.A.F.), Offord Centre for Child Studies (M.A.F.), and CanChild Centre for Child Disability Research (M.A.F.), McMaster University, Hamilton, Canada; Muir Maxwell Epilepsy Centre (R.F.M.C.), The University of Edinburgh; Paediatric Neurosciences (R.F.M.C.), Royal Hospital for Sick Children (Edinburgh), UK; Child Neurology (C.S.C.), IWK Health Centre, Department of Paediatrics, Dalhousie University, Halifax; Department of Clinical Neuroscience (S.W.), University of Calgary; Departments of Paediatrics (S.D.L., K.N.S.) and Epidemiology & Biostatistics (K.N.S.), Western University, London, ON; and Children's Health Research Institute (S.D.L., K.N.S.), Lawson Health Research Institute, London, ON, Canada.
authors.forename: Kathy N
authors.initials: KN
authors.lastname: Speechley
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006304:Health Status; D006801:Humans; D008297:Male; D011788:Quality of Life; D012307:Risk Factors; D012640:Seizures / Q000503:physiopathology*; D013226:Status Epilepticus / Q000503:physiopathology*; D011795:Surveys and Questionnaires