title: Antiviral drug allergy.
abstract: Antiviral drugs used to treat HIV and hepatitis C are common causes of delayed drug hypersensitivities for which many of the more severe reactions have been recently shown to be immunogenetically mediated such as abacavir hypersensitivity where HLA-B(∗)57:01 is now used routinely as a screening test to exclude patients carrying this allele from abacavir prescription. Most antiviral drug allergies consist of mild to moderate delayed rash without other serious features (eg, fever, mucosal involvement, blistering rash, organ impairment. In these cases treatment can be continued with careful observation and symptomatic management and the discontinuation rate is low.
authors.affiliation: Department of Dermatology, Saint-André Hospital, Bordeaux, WA 6150, France.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Milpied-Homsi
authors.affiliation: Division of infectious diseases, Institute of Immunology and Infectious Disease, Murdoch University, Murdoch, Western Australia.
authors.forename: Ellen M
authors.initials: EM
authors.lastname: Moran
authors.affiliation: Division of infectious diseases, Institute of Immunology and Infectious Disease, Murdoch University, Murdoch, Western Australia; Division of Infectious Diseases, Vanderbilt University Medical Center, 1161 21st Avenue South, A-2200, Medical Center North, Nashville, TN 37232-2582, USA. Electronic address: elizabeth.j.phillips@vanderbilt.edu.
authors.forename: Elizabeth J
authors.initials: EJ
authors.lastname: Phillips
mesh_terms: D000998:Antiviral Agents / Q000009:adverse effects* / Q000145:classification; D019468:Disease Management; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D006801:Humans
chemical_list: D000998:Antiviral Agents
keywords: Abacavir; Altered peptide repertoire; Antiretroviral; Human leukocyte antigen; Major histocompatibility complex; Nevirapine; Telaprevir pharmacogenomics