title: Lactate clearance as a marker of mortality in pediatric intensive care unit.
abstract: OBJECTIVE
  To correlate lactate clearance with Pediatric Intensive Care Unit (PICU) mortality.
  
  
  METHODS
  45 (mean age 40.15 mo, 60% males) consecutive admissions in the PICU were enrolled between May 2012 to June 2013. Lactate clearance (Lactate level at admission - level 6 hr later x 100 / lactate level at admission) in first 6 hours of hospitalization was correlated to in-hospital mortality and PRISM score.
  
  
  RESULTS
  Twelve out of 45 patients died. 90% died among those with delayed/poor clearance (clearance <30%) compared to 8.5% in those with good clearance (clearance >30%) (P<0.001). Lactate clearance <30% predicted mortality with sensitivity of 75%, specificity of 97%, positive predictive value of 90%, and negative predictive value of 91.42%. Predictability was comparable to PRISM score >30.
  
  
  CONCLUSIONS
  Lactate clearance at six hours correlates with mortality in the PICU.
authors.affiliation: Department of Pediatrics, St. Stephens Hospital, Tis-Hazari, Delhi, India. Correspondence to: Dr Nirmal Kumar, 4, Rajpur Road, Qtr. B-2, Tis-Hazari, Delhi 110 054, India. nsk9_2000@yahoo.com.
authors.forename: A
authors.initials: A
authors.lastname: Munde
authors.forename: N
authors.initials: N
authors.lastname: Kumar
authors.forename: R S
authors.initials: RS
authors.lastname: Beri
authors.forename: J M
authors.initials: JM
authors.lastname: Puliyel
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007223:Infant; D015278:Intensive Care Units, Pediatric / Q000706:statistics & numerical data*; D019344:Lactic Acid / Q000097:blood*; D008297:Male; D012372:ROC Curve
chemical_list: D019344:Lactic Acid