title: Advancement in the clinical management of intestinal pseudo-obstruction.
abstract: Intestinal pseudo-obstruction is more commonly known in its chronic form (CIPO), a cluster of rare diseases characterized by gastrointestinal muscle and nerve impairment, so severe to result in a markedly compromised peristalsis mimicking an intestinal occlusion. The management of CIPO requires the cooperation of a group of specialists: the disease has to be confirmed by a number of tests to avoid mistakes in the differential diagnosis. The treatment should be aimed at relieving symptoms arising from gut dysmotility (ideally using prokinetic agents), controlling abdominal pain (possibly with non-opioid antinociceptive drugs) and optimizing nutritional support. Furthermore, a thorough diagnostic work-up is mandatory to avoid unnecessary (potentially harmful) surgery and to select patients with clear indication to intestinal or multivisceral transplantation.
authors.affiliation: General Surgery and Transplant Unit, St. Orsola-Malpighi University Hospital, University of Bologna, Bologna, Italy.
authors.forename: Augusto
authors.initials: A
authors.lastname: Lauro
authors.forename: Roberto
authors.initials: R
authors.lastname: De Giorgio
authors.forename: Antonio Daniele
authors.initials: AD
authors.lastname: Pinna
mesh_terms: D000700:Analgesics / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000932:Antiemetics / Q000627:therapeutic use; D003937:Diagnosis, Differential; D019468:Disease Management; D006801:Humans; D007418:Intestinal Pseudo-Obstruction / Q000175:diagnosis* / Q000628:therapy*; D010288:Parenteral Nutrition; D016896:Treatment Outcome
chemical_list: D000700:Analgesics; D000900:Anti-Bacterial Agents; D000932:Antiemetics
keywords: chronic intestinal pseudo-obstruction; enteral nutrition; intestinal diseases; intestinal motility; jejunostomy; manometry; parenteral nutrition; prokinetics; transplantation