title: Synthesis of biotinylated keratan sulfate repeating disaccharides.
abstract: We synthesized four types of keratan and keratan sulfate repeating disaccharides containing non-sulfate, Galβ1-4GlcNAcβ, and three types of sulfates, Gal6Sβ1-4GlcNAcβ, Galβ1-4GlcNAc6Sβ, and Gal6Sβ1-4GlcNAc6Sβ in an efficient and stereo-controlled manner. These disaccharides were conjugated with biotin via a hydrophilic linker at the reducing terminal.
authors.affiliation: a Department of Chemistry and Biotechnology, Graduate School of Engineering , Tottori University , Tottori , Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Takeda
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Tamura
mesh_terms: D019921:Biotinylation; D060326:Chemistry Techniques, Synthetic; D004187:Disaccharides / Q000138:chemical synthesis* / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D007632:Keratan Sulfate / Q000737:chemistry*
chemical_list: D004187:Disaccharides; D007632:Keratan Sulfate
keywords: biotin; glycosaminoglycan; glycosylation; keratan sulfate