title: Baseline characteristics and 1-year follow-up of Chinese atrial fibrillation patients according to age: a registry study.
abstract: BACKGROUND
  The prevalence of atrial fibrillation (AF) increases with age, and may lead to complications and reduced quality of life. The aim of this study was to determine the characteristics, management, and prognosis of Chinese AF patients and whether there were differences according to age.
  
  
  METHODS
  This registry-based study enrolled ambulatory, outpatient clinic, or hospitalized patients with AF in four sites in China. Based on the Birmingham 2009 schema, patients without and with valve lesion were stratified into three groups according to age.
  
  
  RESULTS
  Between September 2008 and April 2011, 2,016 patients were enrolled, including 1,606 patients without valve lesion and 410 patients with valve lesion. Compared with the other two groups, patients >74 years of age were more likely to have morbidity and a CHADS2 score >1, and less likely to receive oral anticoagulants and rhythm-control drugs. At the 1-year follow-up, patients >74 years of age were more likely to have died or suffered a cerebrovascular event or systemic embolism. Age as a continuous variable (subdivided hazard ratio [SHR] 0.98, 95% confidence interval [CI] 0.96-1.01, P = 0.29) was not associated with risk of a cerebrovascular event or systemic embolism at 1-year but age ≥75 years (SHR 1.73, 95% CI 1.05-2.87, P = 0.03) was an independent risk factor for the outcome at 1-year when all AF patients were included.
  
  
  CONCLUSIONS
  Elderly AF patients are inadequately studied and treated compared with younger patients. Education on evidence-based management and the design of randomized controlled trials, specifically targeting the elderly, especially the Chinese elderly, should improve the management and prognosis of this frail segment of the AF population.
authors.affiliation: State Key Laboratory of Cardiovascular Disease, Emergency and Critical Care Centre, Cardiovascular Institute and Fuwai Hospital, National Centre for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Chen
authors.forename: Yan-Min
authors.initials: YM
authors.lastname: Yang
authors.forename: Hui-Qiong
authors.initials: HQ
authors.lastname: Tan
authors.forename: Yan
authors.initials: Y
authors.lastname: Liang
authors.forename: Jun
authors.initials: J
authors.lastname: Zhu
mesh_terms: D000367:Age Factors; D000368:Aged; D044466:Asian People; D001281:Atrial Fibrillation / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012042:Registries; D013997:Time Factors
keywords: Chinese; atrial fibrillation; evidence-based medicine; prognosis; registry