title: Postarthroscopy analgesia using intraarticular levobupivacaine and intravenous dexketoprofen trometamol.
abstract: OBJECTIVE
  The aim of this prospective study was to determine the efficacy of intraarticular levobupivacaine with and without intravenous dexketoprofen trometamol for postarthroscopy analgesia.
  
  
  METHODS
  Sixty patients who underwent arthroscopic knee surgery were randomly assigned to three treatment groups. When the surgical procedure was completed, patients received the following treatments: group I (n = 20) patients received 20 mL intraarticular normal saline and 2 mL intravenous dexketoprofen trometamol (50 mg); group II (n = 20) patients received 20 mL intraarticular 0.5 % levobupivacaine (100 mg) and 2 mL intravenous normal saline; and group III (n = 20) patients received 20 mL intraarticular 0.5 % levobupivacaine (100 mg) and 2 mL intravenous dexketoprofen trometamol (50 mg). The visual analogue scale (VAS) was used, and the total analgesic consumption was assessed at 1, 2, 4, 6, 12, and 24 h post-operatively.
  
  
  RESULTS
  The VAS scores at 1, 2, 4, 6, 12, and 24 h post-operatively were significantly increased in group I and group II compared with group III (p < 0.05). The average VAS score during the first 24 h post-operatively was significantly lower in group III than in group I and group II (p < 0.001). Total meperidine consumption was significantly lower in group III than in groups I and II (p < 0.001).
  
  
  CONCLUSIONS
  Intraarticular levobupivacaine with adjuvant intravenous dexketoprofen trometamol administration provided better pain relief and less analgesic requirement after arthroscopic knee surgery during the first 24 h than that induced by dexketoprofen alone or levobupivacaine intraarticular alone.
  
  
  METHODS
  II.
authors.affiliation: Department of Anesthesiology and Reanimation, Trakya University Medical Faculty, Edirne, 22030, Turkey. sevtaphekimoglu@mynet.com.
authors.forename: Sevtap Hekimoglu
authors.initials: SH
authors.lastname: Sahin
authors.affiliation: Department of Anesthesiology and Reanimation, Trakya University Medical Faculty, Edirne, 22030, Turkey. dilmemis@mynet.com.
authors.forename: Dilek
authors.initials: D
authors.lastname: Memiş
authors.affiliation: Department of Anesthesiology and Reanimation, Trakya University Medical Faculty, Edirne, 22030, Turkey. erkanc@mynet.com.
authors.forename: Erkan
authors.initials: E
authors.lastname: Celik
authors.affiliation: Department of Biostatistics, Trakya University Medical Faculty, Edirne, Turkey. necdetsut@yahoo.com.
authors.forename: Necdet
authors.initials: N
authors.lastname: Sut
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000698:Analgesia / Q000379:methods; D000700:Analgesics / Q000008:administration & dosage*; D000779:Anesthetics, Local / Q000008:administration & dosage*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001182:Arthroscopy / Q000009:adverse effects*; D002045:Bupivacaine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007270:Injections, Intra-Articular; D007660:Ketoprofen / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000077554:Levobupivacaine; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D011446:Prospective Studies; D014325:Tromethamine / Q000008:administration & dosage*; D064232:Visual Analog Scale
chemical_list: D000700:Analgesics; D000779:Anesthetics, Local; D000894:Anti-Inflammatory Agents, Non-Steroidal; D014325:Tromethamine; D007660:Ketoprofen; D000077554:Levobupivacaine; C118296:dexketoprofen trometamol; D002045:Bupivacaine
keywords: Arthroscopy; Dexketoprofen trometamol; Levobupivacaine; Post-operative analgesia; Post-operative pain