title: γ-Secretase: a horseshoe structure brings good luck.
abstract: The intramembrane protease γ-secretase is a key player in signaling and Alzheimer's disease, but its structural features have remained obscure. A structure reported recently reveals a horseshoe-shaped arrangement of 19 transmembrane helices and an extracellular domain positioned for substrate recognition. This advance bodes well for a finer resolution before long.
authors.affiliation: Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: mswolfe@partners.org.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Wolfe
authors.affiliation: Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: dselkoe@partners.org.
authors.forename: Dennis J
authors.initials: DJ
authors.lastname: Selkoe
mesh_terms: D053829:Amyloid Precursor Protein Secretases / Q000737:chemistry*; D006801:Humans; D008958:Models, Molecular
chemical_list: D053829:Amyloid Precursor Protein Secretases