title: Effects of epigallocatechin-3-gallate on the healing of extraction sockets with a periapical lesion: A pilot study in dogs.
abstract: The aim of this study was to characterize the healing process of extraction sockets with a periapical lesion following immediate graft with collagenated bovine bone mineral (CBBM) soaked with epigallocatechin-3-gallate (EGCG). Following induction of periapical lesions in premolars in five dogs, treatment of extraction sockets was divided into three groups: control (no treatment) and two test groups, CBBM with or without EGCG. 3D reconstruction and superimposition of the digital images were used to measure the dimensional changes in alveolar ridge. Histologic specimen was evaluated in all groups. The horizontal ridge widths at 4-mm level were wider in both test groups (3.3 ± 1.7 mm in CBBM; 3.0 ± 1.7 mm in CBBM+EGCG) than in the control group (1.7 ± 2.4 mm). Fibrosis and limited new bone formation were observed in the apical regions of test groups; however, the extent of fibrosis was less in the CBBM+EGCG group. Within the limitations of this study, it was conjectured that adjunctive use of EGCG with CBBM can be a candidate biomaterial in grafting of extraction socket with periapical lesion. Bone regeneration at the coronal region of the CBBM grafted socket might not be influenced by the presence of a periapical lesion.
authors.affiliation: Department of Periodontology, School of Dentistry, Kyung Hee University, Seoul, 134-727, Republic of Korea.
authors.forename: Ji-Youn
authors.initials: JY
authors.lastname: Hong
authors.forename: Jeyoung
authors.initials: J
authors.lastname: Yon
authors.forename: Jung-Seok
authors.initials: JS
authors.lastname: Lee
authors.forename: In-Kyeong
authors.initials: IK
authors.lastname: Lee
authors.forename: Cheryl
authors.initials: C
authors.lastname: Yang
authors.forename: Min-Soo
authors.initials: MS
authors.lastname: Kim
authors.forename: Seong-Ho
authors.initials: SH
authors.lastname: Choi
authors.forename: Ui-Won
authors.initials: UW
authors.lastname: Jung
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D018786:Bone Substitutes / Q000494:pharmacology*; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology; D002417:Cattle; D004285:Dogs; D008297:Male; D009915:Orbit / Q000293:injuries*; D010865:Pilot Projects
chemical_list: D018786:Bone Substitutes; D002392:Catechin; C045651:epigallocatechin gallate
keywords: bio-oss collagen; epigallocatechin gallate; histology; periapical periodontitis; tooth extraction