title: Hypersensitivity from intravenous iron products.
abstract: In the last several years, intravenous therapy with iron products has been more widely used. Although it has been a standard procedure in dialysis-associated anemia since the early 1990s, its use is expanding to a host of conditions associated with iron deficiency, especially young women with heavy uterine bleeding and pregnancy. Free iron is associated with unacceptable high toxicity inducing severe, hemodynamically significant symptoms. Subsequently, formulations that contain the iron as an iron carbohydrate nanoparticle have been designed. With newer formulations, including low-molecular-weight iron dextran, iron sucrose, ferric gluconate, ferumoxytol, iron isomaltoside, and ferric carboxymaltose, serious adverse events are rare.
authors.affiliation: Allergy Unit, Dermatology Clinic, University Hospital Basel, Petersgraben 4, Basel 4031, Switzerland. Electronic address: andreas.bircher@unibas.ch.
authors.forename: Andreas J
authors.initials: AJ
authors.lastname: Bircher
authors.affiliation: Georgetown University School of Medicine, 3900 Reservoir road northwest, Washington, DC 20007, USA; Hematology and Oncology, Private Practice, King Avenue #308, Baltimore, MD 21237, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Auerbach
mesh_terms: D061605:Administration, Intravenous; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control / Q000628:therapy*; D005290:Ferric Compounds / Q000008:administration & dosage / Q000009:adverse effects; D005296:Ferrous Compounds / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control / Q000628:therapy; D006969:Hypersensitivity, Immediate / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control / Q000628:therapy; D007501:Iron / Q000008:administration & dosage / Q000009:adverse effects*; D012307:Risk Factors
chemical_list: D005290:Ferric Compounds; D005296:Ferrous Compounds; D007501:Iron
keywords: Adverse drug reaction; Hypersensitivity; Intravenous iron; Toxicity