title: The role of Ki-67 in women with a resistant prolactinoma: a retrospective analysis in 199 hospitalized patients over a period of 5 years.
abstract: Proliferation-associated antigen Ki-67 is used for the histological evaluation of different tumors. Few studies have been conducted on women with a resistant prolactinoma. To better define the characteristics and to evaluate the differences between patients with different Ki-67 labeling index (LI), a retrospective study was designed to recruit 199 females with a resistant prolactinoma. The patients were divided into two groups, patients with Ki-67 LI≥3% and patients with Ki-67 LI<3%. Tumors in the LI>3% group were also larger (p=0.043), had a higher rate of invasion (p=0.014), and were associated with more frequent polyuria and polydipsia (p=0.008) compared to the LI<3% group. The pre- and post-operative PRL levels in the LI>3% group remained significantly higher compared to patients with LI<3% (p<0.05). The incidences of transient diabetes insipidus and hyponatremia in the LI>3% group were also significantly higher (p=0.037, p=0.041). Additionally, the postoperative PRL normalization rate was lower in patients with LI>3% compared with patients with LI<3% (p=0.028). The recurrence rate in the LI>3% and LI<3% groups were 27.27% and 8.47%, respectively. In conclusion, high Ki-67 LI is predictive sign of a poor prognosis in women with resistant prolactinoma.
authors.affiliation: Department of Laboratory Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Ji'nan, PR China.
authors.forename: Chao
authors.initials: C
authors.lastname: Lu
authors.affiliation: College of Life Science, Shandong Normal University, Ji'nan, PR China.
authors.forename: Zongming
authors.initials: Z
authors.lastname: Ren
authors.affiliation: Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University, Ji'nan, PR China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Huan
authors.affiliation: Department of Outpatient, Yidu Central Hospital of Weifang, Qingzhou, PR China.
authors.forename: Guihua
authors.initials: G
authors.lastname: Cui
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000502:physiology*; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000401:mortality / Q000473:pathology*; D011379:Prognosis; D011388:Prolactin / Q000097:blood; D015175:Prolactinoma / Q000401:mortality / Q000473:pathology*; D012189:Retrospective Studies
chemical_list: D019394:Ki-67 Antigen; D011388:Prolactin