title: FVIII stabilization: VWF D'D3 will do.
abstract: In this issue of Blood, Yee et al1 have demonstrated that expression or infusion of a truncated von Willebrand factor (VWF) fragment containing the factor VIII (FVIII)-binding D′D3 region of VWF is sufficient to stabilize endogenous FVIII levels in VWF-deficient mice. In the absence of the carrier function of VWF, FVIII is susceptible to rapid proteolysis and clearance resulting in markedly reduced plasma levels of FVIII that contribute to a bleeding diathesis.
authors.affiliation: QUEEN'S UNIVERSITY.
authors.forename: Laura L
authors.initials: LL
authors.lastname: Swystun
authors.affiliation: QUEEN'S UNIVERSITY.
authors.forename: David
authors.initials: D
authors.lastname: Lillicrap
mesh_terms: D000818:Animals; D005169:Factor VIII / Q000378:metabolism*; D006801:Humans; D010446:Peptide Fragments / Q000378:metabolism*; D014841:von Willebrand Factor / Q000378:metabolism*
chemical_list: D010446:Peptide Fragments; D014841:von Willebrand Factor; D005169:Factor VIII