title: Association Analysis of TEC Polymorphisms with Aspirin-Exacerbated Respiratory Disease in a Korean Population.
abstract: The tyrosine-protein kinase Tec (TEC) is a member of non-receptor tyrosine kinases and has critical roles in cell signaling transmission, calcium mobilization, gene expression, and transformation. TEC is also involved in various immune responses, such as mast cell activation. Therefore, we hypothesized that TEC polymorphisms might be involved in aspirin-exacerbated respiratory disease (AERD) pathogenesis. We genotyped 38 TEC single nucleotide polymorphisms in a total of 592 subjects, which comprised 163 AERD cases and 429 aspirin-tolerant asthma controls. Logistic regression analysis was performed to examine the associations between TEC polymorphisms and the risk of AERD in a Korean population. The results revealed that TEC polymorphisms and major haplotypes were not associated with the risk of AERD. In another regression analysis for the fall rate of forced expiratory volume in 1 second (FEV1) by aspirin provocation, two variations (rs7664091 and rs12500534) and one haplotype (TEC_BL2_ht4) showed nominal associations with FEV1 decline (p = 0.03-0.04). However, the association signals were not retained after performing corrections for multiple testing. Despite TEC playing an important role in immune responses, the results from the present study suggest that TEC polymorphisms do not affect AERD susceptibility. Findings from the present study might contribute to the genetic etiology of AERD pathogenesis.
authors.affiliation: Research Institute for Basic Science, Sogang University, Seoul 121-742, Korea. ; Department of Life Science, Sogang University, Seoul 121-742, Korea.
authors.forename: Jin Sol
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Laboratory of Translational Genomics, Samsung Genome Institute, Samsung Medical Center, Seoul 135-710, Korea.
authors.forename: Joon Seol
authors.initials: JS
authors.lastname: Bae
authors.affiliation: Department of Genetic Epidemiology, SNP Genetics, Inc., Seoul 153-801, Korea.
authors.forename: Byung-Lae
authors.initials: BL
authors.lastname: Park
authors.affiliation: Department of Genetic Epidemiology, SNP Genetics, Inc., Seoul 153-801, Korea.
authors.forename: Hyun Sub
authors.initials: HS
authors.lastname: Cheong
authors.affiliation: Research Institute for Basic Science, Sogang University, Seoul 121-742, Korea.
authors.forename: Jeong-Hyun
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Life Science, Sogang University, Seoul 121-742, Korea.
authors.forename: Jason Yongha
authors.initials: JY
authors.lastname: Kim
authors.affiliation: Department of Life Science, Sogang University, Seoul 121-742, Korea. ; Department of Genetic Epidemiology, SNP Genetics, Inc., Seoul 153-801, Korea.
authors.forename: Suhg
authors.initials: S
authors.lastname: Namgoong
authors.affiliation: Department of Life Science, Sogang University, Seoul 121-742, Korea. ; Department of Genetic Epidemiology, SNP Genetics, Inc., Seoul 153-801, Korea.
authors.forename: Ji-On
authors.initials: JO
authors.lastname: Kim
authors.affiliation: Division of Allergy and Respiratory Medicine, Soonchunhyang University Seoul Hospital, Seoul 140-743, Korea.
authors.forename: Choon-Sik
authors.initials: CS
authors.lastname: Park
authors.affiliation: Department of Life Science, Sogang University, Seoul 121-742, Korea. ; Department of Genetic Epidemiology, SNP Genetics, Inc., Seoul 153-801, Korea.
authors.forename: Hyoung Doo
authors.initials: HD
authors.lastname: Shin
keywords: Tec protein tyrosine kinase; aspirin-exacerbated respiratory disease; aspirin-tolerant asthma; genetic polymorphisms; haplotypes