title: Yeast central nervous system infection in a critically ill patient: a case report.
abstract: BACKGROUND
  Invasive fungal infections are alarmingly common in intensive care unit patients; invasive fungal infections are associated with increased morbidity and mortality. Risk factors are the increased use of indwelling central venous catheters, the use of broad spectrum antibiotics, parenteral nutrition, renal replacement therapy and immunosuppression. Diagnosis of these infections might be complicated, requiring tissue cultures. In addition, therapy of invasive fungal infections might be difficult, given the rising resistance of fungi to antifungal agents.
  
  
  METHODS
  We describe the case of a 28-year-old Greek man with yeast central nervous system infection.
  
  
  CONCLUSIONS
  Difficult-to-treat fungal infections may complicate the clinical course of critically ill patients and render their prognosis unfavorable. This report presents a case that was rare and difficult to treat, along with a thorough review of the investigation and treatment of these kinds of fungal infections in critically ill patients.
authors.affiliation: 2nd Department of Critical Care, University Hospital ATTIKON, Athens, Greece. ffrantzeska@gmail.com.
authors.forename: Frantzeska
authors.initials: F
authors.lastname: Frantzeskaki
authors.forename: Chryssi
authors.initials: C
authors.lastname: Diakaki
authors.forename: Michalis
authors.initials: M
authors.lastname: Rizos
authors.forename: Maria
authors.initials: M
authors.lastname: Theodorakopoulou
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Papadopoulos
authors.forename: Anastasia
authors.initials: A
authors.lastname: Antonopoulou
authors.forename: Nikitas
authors.initials: N
authors.lastname: Nikitas
authors.forename: Michail
authors.initials: M
authors.lastname: Lignos
authors.forename: Elias
authors.initials: E
authors.lastname: Brountzos
authors.forename: Aristea
authors.initials: A
authors.lastname: Velegraki
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Paramythiotou
authors.forename: John
authors.initials: J
authors.lastname: Panagyotides
authors.forename: Apostolos
authors.initials: A
authors.lastname: Armaganidis
authors.forename: George
authors.initials: G
authors.lastname: Dimopoulos
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D001706:Biopsy; D020314:Central Nervous System Fungal Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology*; D016638:Critical Illness; D003937:Diagnosis, Differential; D003952:Diagnostic Imaging; D006689:Hodgkin Disease; D006801:Humans; D016867:Immunocompromised Host; D008297:Male
chemical_list: D000935:Antifungal Agents