title: [Association between AIF-1 gene polymorphisms and response to rheumatoid arthritis treatment with sulphasalazine].
abstract: BACKGROUND
  AIF-1 is an inflammatory cytokine influencing the immune system. There are increased levels of AIF-1 in the synovial fluid of patients with rheumatoid arthritis (RA). Sulfasalazine still remains the mainstay for the treatment of RA. It has an anti-inflammatory effect, inhibiting the action of inflammatory mediators. The aim of our study was to examine the association between AIF-1 (rs2269475:C>T, rs2736182:G>A, rs2259571:A>C) polymorphisms and response to sulfasalazine treatment in RA patients.
  
  
  METHODS
  A total of 112 RA patients were enrolled in the study.
  
  
  RESULTS
  There were no statistically significant associations between AIF-1 polymorphisms and response to sulphasalazine treatment.
  
  
  CONCLUSIONS
  The results of this study suggest a lack of association between AIF-1 gene polymorphisms and response to sulphasalazine treatment.
authors.forename: Ewa
authors.initials: E
authors.lastname: Dabrowska-Zamojcin
authors.forename: Maria-Magdalena
authors.initials: MM
authors.lastname: Herczyńska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Pawlik
mesh_terms: D018501:Antirheumatic Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000235:genetics* / Q000276:immunology; D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008840:Microfilament Proteins; D011110:Polymorphism, Genetic; D012460:Sulfasalazine / Q000627:therapeutic use*; D013582:Synovial Fluid / Q000276:immunology; D016896:Treatment Outcome
chemical_list: C112986:AIF1 protein, human; D018501:Antirheumatic Agents; D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; D008840:Microfilament Proteins; D012460:Sulfasalazine