title: Development and validation of a modelling framework for simulating 2D-mammography and breast tomosynthesis images.
abstract: Planar 2D x-ray mammography is generally accepted as the preferred screening technique used for breast cancer detection. Recently, digital breast tomosynthesis (DBT) has been introduced to overcome some of the inherent limitations of conventional planar imaging, and future technological enhancements are expected to result in the introduction of further innovative modalities. However, it is crucial to understand the impact of any new imaging technology or methodology on cancer detection rates and patient recall. Any such assessment conventionally requires large scale clinical trials demanding significant investment in time and resources. The concept of virtual clinical trials and virtual performance assessment may offer a viable alternative to this approach. However, virtual approaches require a collection of specialized modelling tools which can be used to emulate the image acquisition process and simulate images of a quality indistinguishable from their real clinical counterparts. In this paper, we present two image simulation chains constructed using modelling tools that can be used for the evaluation of 2D-mammography and DBT systems. We validate both approaches by comparing simulated images with real images acquired using the system being simulated. A comparison of the contrast-to-noise ratios and image blurring for real and simulated images of test objects shows good agreement ( < 9% error). This suggests that our simulation approach is a promising alternative to conventional physical performance assessment followed by large scale clinical trials.
authors.affiliation: Centre for Vision, Speech, and Signal Processing, Medical Imaging Group, University of Surrey, Guildford, GU2 7XH, UK.
authors.forename: Premkumar
authors.initials: P
authors.lastname: Elangovan
authors.forename: Lucy M
authors.initials: LM
authors.lastname: Warren
authors.forename: Alistair
authors.initials: A
authors.lastname: Mackenzie
authors.forename: Alaleh
authors.initials: A
authors.lastname: Rashidnasab
authors.forename: Oliver
authors.initials: O
authors.lastname: Diaz
authors.forename: David R
authors.initials: DR
authors.lastname: Dance
authors.forename: Kenneth C
authors.initials: KC
authors.lastname: Young
authors.forename: Hilde
authors.initials: H
authors.lastname: Bosmans
authors.forename: Celia J
authors.initials: CJ
authors.lastname: Strudley
authors.forename: Kevin
authors.initials: K
authors.lastname: Wells
mesh_terms: D000465:Algorithms; D008327:Mammography / Q000379:methods*; D011856:Radiographic Image Enhancement / Q000379:methods*; D014965:X-Rays