title: Zinc dependent endopeptidases of matrix metalloproteinases-9 expressions is associated with tumor metastases of oral squamous cell carcinoma in Chinese population: a meta-analysis.
abstract: Matrix metalloproteinase-9 (MMP-9) is an important member of zinc dependent endopeptidases family and is considered to be involved in the invasion and metastasis of cancer cells. Many studies were published to assess the prognostic role of MMP-9 expression in patients with oral squamous cell Carcinoma, but the findings from those studies were inconsistent in Chinese population. We searched eligible studies in Pubmed, Embase, and Web of Science databases. Six studies with a total of 556 patients were finally included into the meta-analysis. The pooled odds ratios (OR) with the corresponding 95% confidence interval (95% CIs) for positive rate of MMP-9 were calculated by using meta-analysis. Overall, MMP-9 positive expression was associated with tumor metastases in patients with oral squamous cell Carcinoma (fixed-effects OR 4.24, 95% CI 2.25-7.99, P < 0.001; random-effects OR 4.35, 95% CI 2.31-8.21, P < 0.001). Our results indicated that MMP-9 expression is associated with tumor metastases in patients with oral squamous cell carcinoma, and patients with higher MMP-9 expression have less tumor metastases.
authors.affiliation: Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Wannan Medical College Wuhu, Anhui 241002, People's Republic of China.
authors.forename: De-Tao
authors.initials: DT
authors.lastname: Tao
authors.affiliation: School of Stomatology, Wannan Medical College Wuhu, Anhui 241001, People's Republic of China.
authors.forename: Zhen-Lin
authors.initials: ZL
authors.lastname: Gao
authors.affiliation: School of Stomatology, Wannan Medical College Wuhu, Anhui 241001, People's Republic of China.
authors.forename: Jing-Ping
authors.initials: JP
authors.lastname: Zhou
authors.affiliation: School of Public Health, Wannan Medical College Wuhu, Anhui 241002, People's Republic of China.
authors.forename: Lian-Ping
authors.initials: LP
authors.lastname: He
authors.affiliation: School of Stomatology, Wannan Medical College Wuhu, Anhui 241001, People's Republic of China.
authors.forename: Liu-Xia
authors.initials: LX
authors.lastname: Shi
authors.affiliation: School of Stomatology, Wannan Medical College Wuhu, Anhui 241001, People's Republic of China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Fang
authors.affiliation: School of Stomatology, Wannan Medical College Wuhu, Anhui 241001, People's Republic of China.
authors.forename: Wen-Jing
authors.initials: WJ
authors.lastname: Liu
authors.affiliation: School of Stomatology, Wannan Medical College Wuhu, Anhui 241001, People's Republic of China.
authors.forename: Chao
authors.initials: C
authors.lastname: Deng
keywords: MMP-9; oral squamous cell carcinoma; tumor metastases