title: Utility of fluorodeoxyglucose positron emission tomography/computed tomography in patients with fever of unknown origin diagnosed as lymphoma.
abstract: OBJECTIVE
  To assess the efficacy of fluorine-18 fluorodeoxyglucose positron emission tomography ((18)F-FDG PET)/computed tomography (CT) in the diagnosis of patients with fever of unknown origin (FUO), who were finally diagnosed as lymphoma.
  
  
  METHODS
  A retrospective study was performed in the First Affiliated Hospital, School of Medicine of Zhejiang University, China, from March 2009 to March 2012. The PET/CT images of consecutive patients with FUO were analyzed. Within 1 week of PET/CT scanning, additional histological tests were also performed if clinically needed.
  
  
  RESULTS
  A total of 73 consecutive patients were included. Of these, 34 (47%) had a PET/CT finding suggestive of the presence of lymphoma and 29 (85%) had a diagnosis of confirmed lymphoma; 39 (53%) had a PET/CT result revealing the absence of lymphoma and 4 (10%) were diagnosed by biopsy as having lymphoma, . The most frequent lymphoma diagnosis was peripheral T cell lymphoma (n = 16; 55%), followed by diffuse large B cell lymphoma (n = 9; 31%). The accuracy of PET/CT was 88%.
  
  
  CONCLUSIONS
  In this study, PET/CT had high diagnostic accuracy in patients with FUO resulting from lymphoma, which indicated that PET/CT scanning was a valuable diagnostic tool for these groups of patients with FUO.
authors.affiliation: Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, PR China.
authors.forename: Zi-Ke
authors.initials: ZK
authors.lastname: Sheng
authors.forename: Jin
authors.initials: J
authors.lastname: Ye
authors.forename: Jun-Jie
authors.initials: JJ
authors.lastname: Li
authors.forename: Kui
authors.initials: K
authors.lastname: Zhao
authors.forename: Ji-Fang
authors.initials: JF
authors.lastname: Sheng
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002681:China; D005260:Female; D005335:Fever of Unknown Origin / Q000000981:diagnostic imaging / Q000209:etiology*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008223:Lymphoma / Q000150:complications* / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18