title: Differential expression of glypican-1 in ameloblastoma variants.
abstract: Although benign, ameloblastomas are locally invasive and destructive tumors of the jawbones. The glypicans comprise a family of glycosylphosphatidylinositol-anchored proteoglycans that, by virtue of their cell-surface localization and heparin sulfate chain composition, might regulate the response of cells to numerous heparin-binding growth factors, cell adhesion molecules, and extracellular matrix components. The expression of glypican-1 is differentially altered among different types of malignancies, suggesting a possible role in the tumorigenesis and biological behavior of these neoplasms. The aim of this study was to determine the expression of glypican-1 and then hypothesize the possible role that this protein may play in the biological behavior of ameloblastomas. We assessed the presence of glypican-1 by immunohistochemical staining analyses in a series of 80 cases of different types of ameloblastomas. Desmoplastic ameloblastomas exhibited the highest expression of glypican-1 (100%), followed by the peripheral (66%), solid/multicystic (51.2%), and unicystic (47.2%) types, showing statistically significant differences among them (P<0.001). Differences detected in glypican-1 expression among different subtypes of ameloblastomas, could be suggesting a possible association with their different biological behavior.
authors.affiliation: *Department of Molecular Pathology, School of Dentistry, Universidad de la República (UDELAR), Montevideo, Uruguay †Department of HealthCare, Universidad Autónoma Metropolitana-Xochimilco, Mexico City, Mexico.
authors.forename: Ronell
authors.initials: R
authors.lastname: Bologna-Molina
authors.forename: Adalberto
authors.initials: A
authors.lastname: Mosqueda-Taylor
authors.forename: Nelly
authors.initials: N
authors.lastname: Molina-Frechero
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000564:Ameloblastoma / Q000145:classification / Q000175:diagnosis* / Q000473:pathology; D063646:Carcinogenesis; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D053673:Glypicans / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D007573:Jaw Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009808:Odontogenic Tumors / Q000145:classification / Q000175:diagnosis* / Q000473:pathology; D055815:Young Adult
chemical_list: D053673:Glypicans