title: Controlled release of liposome-encapsulated Naproxen from core-sheath electrospun nanofibers.
abstract: Naproxen (NAP) loaded nanofibers of different structures have been successfully prepared by electrospinning. The structures of the nanofibers are NAP and cellulose acetate (CA) mixed nanofibers (NF-1), nanofibers with NAP/CA mixed core and CA sheath (NF-2), and NAP loaded liposomes and sodium hyaluronate (HA-Na) mixed core with CA sheath (NF-3). The structure and morphology of the nanofibers were characterized and the drug release behaviors were investigated. It was found that NAP can disperse in the HA-Na or CA matrix in molecular level without formation of NAP crystals and dimers. The drug release behaviors of NF-1 and NF-2 show a non-Fickian diffusion mechanism, while the NF-3 shows a specific drug release behavior with a burst release within 8h followed by a sustained drug release for 12 days. The particular two-stage drug release behavior of NF-3 nanofibers offers the materials promising applications as wound dressing materials.
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Science, Beijing 100049, China.
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Li
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Hongliang
authors.initials: H
authors.lastname: Kang
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Science, Beijing 100049, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Che
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Science, Beijing 100049, China.
authors.forename: Zhijing
authors.initials: Z
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Science, Beijing 100049, China.
authors.forename: Pingping
authors.initials: P
authors.lastname: Li
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Li
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Science, Beijing 100049, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Science, Beijing 100049, China.
authors.forename: Chun
authors.initials: C
authors.lastname: Cao
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. Electronic address: rgliu@iccas.ac.cn.
authors.forename: Ruigang
authors.initials: R
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; National Research Center for Engineering Plastics, Technical Institute of Physics & Chemistry, Chinese Academy of Sciences, Beijing 100190, China. Electronic address: yhuang@mail.ipc.ac.cn.
authors.forename: Yong
authors.initials: Y
authors.lastname: Huang
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry / Q000648:ultrastructure; D003692:Delayed-Action Preparations / Q000737:chemistry*; D065546:Drug Liberation; D008081:Liposomes / Q000737:chemistry*; D057139:Nanofibers / Q000737:chemistry*; D009288:Naproxen / Q000008:administration & dosage*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D008081:Liposomes; C005062:acetylcellulose; D009288:Naproxen; D002482:Cellulose
keywords: Cellulose acetate; Core-sheath nanofibers; Electrospinning; Liposomes; Naproxen; Sustained drug release