title: Ellagic acid protects Lipopolysaccharide/D-galactosamine-induced acute hepatic injury in mice.
abstract: Ellagic acid, a natural polyphenol found in certain fruits, nuts and vegetables, has been reported to have anti-inflammatory, anti-tumor, and antioxidant activities. However, the effects of ellagic acid on acute hepatic injury have not been reported. In the present study, we investigated the effects of ellagic acid on Lipopolysaccharide/d-galactosamine-induced acute hepatic injury in mice. The results showed that LPS/GalN increased hepatic malondialdehyde (MDA) content, TNF-α level, serum ALT and AST levels and TNF-α level. However, these changes were attenuated by ellagic acid. Western blot analysis showed that ellagic acid inhibited LPS/GalN-induced NF-κB activation. Furthermore, ellagic acid induced the expression of Nrf2 and heme oxygenase-1. In conclusion, our results showed that ellagic acid protected against LPS/GalN-induced liver injury by enhancing the antioxidative defense system and reducing inflammatory response.
authors.affiliation: Department of Gastroenterology Surgery, Renji Hospital School of Medicine Shanghai Jiao Tong University, Shanghai 200127, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Gu
authors.affiliation: Department of Gastroenterology Surgery, Renji Hospital School of Medicine Shanghai Jiao Tong University, Shanghai 200127, China.
authors.forename: Wen-sheng
authors.initials: WS
authors.lastname: Deng
authors.affiliation: Department of Gastroenterology Surgery, Renji Hospital School of Medicine Shanghai Jiao Tong University, Shanghai 200127, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Gastroenterology Surgery, Renji Hospital School of Medicine Shanghai Jiao Tong University, Shanghai 200127, China.
authors.forename: Chun-hui
authors.initials: CH
authors.lastname: Jiang
authors.affiliation: Department of Gastroenterology Surgery, Renji Hospital School of Medicine Shanghai Jiao Tong University, Shanghai 200127, China.
authors.forename: Long-ci
authors.initials: LC
authors.lastname: Sun
authors.affiliation: Department of Gastroenterology Surgery, Renji Hospital School of Medicine Shanghai Jiao Tong University, Shanghai 200127, China.
authors.forename: Xiao-fei
authors.initials: XF
authors.lastname: Sun
authors.affiliation: Department of Gastroenterology Surgery, Renji Hospital School of Medicine Shanghai Jiao Tong University, Shanghai 200127, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Xu
authors.affiliation: Department of Gastroenterology Surgery, Renji Hospital School of Medicine Shanghai Jiao Tong University, Shanghai 200127, China. Electronic address: renjizhouhong@163.com.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhou
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001219:Aspartate Aminotransferases / Q000097:blood; D004610:Ellagic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D005688:Galactosamine; D051547:Heme Oxygenase-1 / Q000378:metabolism; D008070:Lipopolysaccharides; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D017114:Liver Failure, Acute / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D051267:NF-E2-Related Factor 2 / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D008070:Lipopolysaccharides; D008565:Membrane Proteins; D051267:NF-E2-Related Factor 2; D016328:NF-kappa B; C495636:Nfe2l2 protein, mouse; D020011:Protective Agents; D014409:Tumor Necrosis Factor-alpha; D004610:Ellagic Acid; D005688:Galactosamine; D051547:Heme Oxygenase-1; C496542:Hmox1 protein, mouse; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
keywords: Ellagic acid; Lipopolysaccharide (LPS); NF-κB; Nrf2