title: State of integral remodeling parameters of target organs in patients with essential hypertension and obesity.
abstract: Arterial hypertension combined with obesity is a very common form of comorbid disease in most countries all over the world. The combination of these diseases is characterized by mutual burdening of remodelling processes in important target organs, what greatly increases the risk of cardiovascular complications and death. The mechanisms of injury progression to vital organs in essential hypertension (EH) and obesity have some common features. The most important risk factors of target organs damage are hemodynamic and neurohumoral: inflammatory, effectors of the renin- angiotensin-aldosterone system, insulin resistance and others. Polyethiologic remodelling, lack of knowledge concerning violations in structural and functional status of important target organs and mechanisms of the interactions of their progression with this comorbidity require further study of these issues. The objective of the study was the comparative study of the state of integral indicators of structural and functional state of the heart, blood vessels and liver in patients with EH second stage with normal body weight and with concomitant obesity I and II degrees. This study found that the presence of obesity I and II in patients with EH stage II is associated with the concentric type of left ventricular hypertrophy, saved by its ejection fraction and impaired diastolic filling processes. For the patients with EH in the early stages of obesity the following characteristics are quite typical: considerable increase of intima media thickness in the carotid arteries, increasing the stiffness in the main arteries and liver parenchyma, impaired of the functional state of endothelial.
authors.affiliation: Kharkiv Medical Academy of Postgraduate Education; Sumy Outpatient hospital №3; Sumy State University, Ukraine.
authors.forename: M
authors.initials: M
authors.lastname: Kochueva
authors.affiliation: Kharkiv Medical Academy of Postgraduate Education; Sumy Outpatient hospital №3; Sumy State University, Ukraine.
authors.forename: V
authors.initials: V
authors.lastname: Sukhonos
authors.affiliation: Kharkiv Medical Academy of Postgraduate Education; Sumy Outpatient hospital №3; Sumy State University, Ukraine.
authors.forename: A
authors.initials: A
authors.lastname: Shalimova
authors.affiliation: Kharkiv Medical Academy of Postgraduate Education; Sumy Outpatient hospital №3; Sumy State University, Ukraine.
authors.forename: V
authors.initials: V
authors.lastname: Psareva
authors.affiliation: Kharkiv Medical Academy of Postgraduate Education; Sumy Outpatient hospital №3; Sumy State University, Ukraine.
authors.forename: N
authors.initials: N
authors.lastname: Kirichenko
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000503:physiopathology; D001808:Blood Vessels / Q000503:physiopathology*; D059168:Carotid Intima-Media Thickness; D000075222:Essential Hypertension; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000473:pathology*; D007333:Insulin Resistance; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000473:pathology*; D012084:Renin-Angiotensin System