title: [Clinical observation of traumatic granuloma after CO₂ laser cordectomy and laryngopharyngeal reflux].
abstract: OBJECTIVE
  Through clinical observation of granuloma after CO₂ laser cordectomy under suspensive laryngoscope to discuss the effects of laryngopharyngeal reflux(LPR) to traumatic granuloma.
  
  
  METHODS
  According to the classification of depth and range of CO₂ laser cordectomy, 111 cases were divided into 5 groups, and the incidence of postoperative granuloma of each group was observed. The largest number of the 5 groups was 49 cases of type III CO₂ laser cordectomy which was subdivided into 4 groups according to whether or not laryngopharyngeal reflux and whether or not proton pump inhibitor (PPI) treatment.
  
  
  RESULTS
  In 111 cases, 56 cases (50.5%) developed granuloma after CO₂ laser cordectomy. The incidence of traumatic granuloma after surgery was 10% (1/10), 26.1% (6/23), 53.1% (26/49), 78.6% (11/14), 80.0% (12/15) in I, II, III, IV, V type, respectively. It had statistical significance in chi-square test between 5 kinds of operative classification and the incidences of postoperative granuloma (χ² = 20.32, P < 0.01) and Spearman correlation analysis showed positive correlation between classification of operation and incidences of granuloma (r = 0.44, P < 0.01). According to LPR (-), LPR (+)and PPI (+), PPI (-), the incidence of granuloma had statistical significance in these 4 group patients of 49 type III cases (χ²= 5.83, P < 0.05). The incidence of granuloma after surgery was the lowest in LPR (-) PPI (+) group (30%) and the highest in LPR (+) PPI (-) group (80%), and it showed significant difference (χ² = 6.25, P < 0.05).
  
  
  CONCLUSIONS
  With the increase of removal depth and the range after CO₂ laser cordectomy, it appears rising trend in incidence of granuloma. Laryngopharyngeal reflux and PPI therapy on the incidence of traumatic granuloma has certain influence.
authors.affiliation: Department of Otorhinolaryngology, Shengjing Hospital, China Medical University, Shenyang 110004, China. Email: wanglp@sj-hospital.org.
authors.forename: Liping
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Otorhinolaryngology, Shengjing Hospital, China Medical University, Shenyang 110004, China.
authors.forename: Shishang
authors.initials: S
authors.lastname: Sun
authors.affiliation: Department of Otorhinolaryngology, Shengjing Hospital, China Medical University, Shenyang 110004, China.
authors.forename: Sining
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Otorhinolaryngology, Shengjing Hospital, China Medical University, Shenyang 110004, China.
authors.forename: Dashuai
authors.initials: D
authors.lastname: Liang
authors.affiliation: Department of Otorhinolaryngology, Shengjing Hospital, China Medical University, Shenyang 110004, China.
authors.forename: Wenyue
authors.initials: W
authors.lastname: Ji
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006099:Granuloma / Q000453:epidemiology* / Q000473:pathology; D006801:Humans; D057045:Laryngopharyngeal Reflux; D007828:Laryngoscopy / Q000009:adverse effects* / Q000379:methods; D053685:Laser Therapy / Q000009:adverse effects*; D054020:Lasers, Gas; D008297:Male; D008875:Middle Aged