title: Chemotherapy-related cardiomyopathy: a neglected aspect of cancer survivorship.
abstract: Improvements in survival from cancer have led to a large population who are at risk of late complications of chemotherapy. One of the most serious cardiovascular complications is chemotherapy-related cardiomyopathy (CRC), which may become clinically overt years or even decades after treatment and has over threefold higher mortality rate compared with idiopathic dilated cardiomyopathy. The early stages of this condition appear to respond well to cardioprotective medications (i.e. angiotensin-converting enzyme inhibitors, β-blockers). Periodic cardiac monitoring is necessary in this population to identify patients who would benefit from treatment. Cardio-oncology clinics have been established in recognition of this hazard in survivorship. This review summarises the epidemiology and pathophysiology of CRC, the evidence base for different non-invasive imaging modalities for screening and diagnosis and the rationale for treatment.
authors.affiliation: Cardiovascular Research Department, Menzies Research Institute Tasmania, Hobart, Tasmania, Australia.
authors.forename: M T
authors.initials: MT
authors.lastname: Nolan
authors.forename: R M
authors.initials: RM
authors.lastname: Lowenthal
authors.forename: A
authors.initials: A
authors.lastname: Venn
authors.forename: T H
authors.initials: TH
authors.lastname: Marwick
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D002311:Cardiomyopathy, Dilated / Q000139:chemically induced* / Q000175:diagnosis; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D019317:Evidence-Based Medicine; D006333:Heart Failure / Q000139:chemically induced* / Q000517:prevention & control; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D018579:Patient Selection; D012307:Risk Factors; D017741:Survivors; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents; D002316:Cardiotonic Agents
keywords: LV dysfunction; cardiotoxicity; chemotherapy; echocardiography; strain imaging