title: [Influence of polymicroelement preparation esmin on hydrogen sulfide levels and indices of pro- and antioxidant system in the rat myocardium of different age].
abstract: The influence of microelement preparation Esmin on hydrogen sulfide (H2S) levels, activity of H2S-producing enzymes and indices of pro-/antioxidant system in the myocardium of different age rats were investigated. In the process of aging the levels of H2S and activities of H2S-producing enzymes (cysteine aminotransferase, cystathionine-gamma-lyase) are reduced in the myocardium; the pro-/antioxidant balance is destabilized (NADPH-oxidase activity is increased and thioredoxin reductase activity is decreased). Esmin administration effectively reduces age-related changes in the myocardium of old rats: increases H2S levels and activity of H2S-producing enzymes, restores pro-/antioxidant balance.
authors.forename: N V
authors.initials: NV
authors.lastname: Zaichko
authors.forename: O S
authors.initials: OS
authors.lastname: Ol'khovs'kyĭ
authors.forename: A V
authors.initials: AV
authors.lastname: Mel'nyk
authors.forename: P O
authors.initials: PO
authors.lastname: Iurchenko
authors.forename: H S
authors.initials: HS
authors.lastname: Hryhor"ieva
authors.forename: N F
authors.initials: NF
authors.lastname: Konakhovych
mesh_terms: D000375:Aging / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D003542:Cystathionine gamma-Lyase / Q000378:metabolism*; D057075:Enzyme Assays; D006862:Hydrogen Sulfide / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D019255:NADPH Oxidases / Q000378:metabolism; D051381:Rats; D013880:Thioredoxin-Disulfide Reductase / Q000378:metabolism; D014131:Trace Elements / Q000008:administration & dosage*; D000637:Transaminases / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D014131:Trace Elements; D019255:NADPH Oxidases; D013880:Thioredoxin-Disulfide Reductase; D000637:Transaminases; C019968:cysteine aminotransferase; D003542:Cystathionine gamma-Lyase; D006862:Hydrogen Sulfide