title: Regulation of integrin activity by phosphorylation.
abstract: Integrins are heterodimeric complex type I membrane proteins involved in cellular adhesion and signaling. They exist as inactive molecules in resting cells, and need activation to become adhesive. Although much is known about their structure, and a large number of interacting molecules have been described, we still only partially understand how their activities are regulated. In this review we focus on the leukocyte-specific β2-integrins and, specifically, on the role of integrin phosphorylation in the regulation of activity. Phosphorylation reactions can be fast and reversible, thus enabling strictly directed regulatory activities both time-wise and locally in specific regions of the plasma membrane in different leukocytes.
authors.affiliation: Division of Biochemistry and Biotechnology, Department of Biosciences, University of Helsinki, Viikinkaari 5, 00014, Helsinki, Finland, carl.gahmberg@helsinki.fi.
authors.forename: Carl G
authors.initials: CG
authors.lastname: Gahmberg
authors.forename: Mikaela
authors.initials: M
authors.lastname: Grönholm
authors.forename: Liisa M
authors.initials: LM
authors.lastname: Uotila
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D016023:Integrins / Q000737:chemistry / Q000502:physiology*; D008969:Molecular Sequence Data; D010766:Phosphorylation; D017434:Protein Structure, Tertiary; D016608:Talin / Q000378:metabolism
chemical_list: D016023:Integrins; D016608:Talin