title: Cutaneous metastasis from lung cancer. Case report.
abstract: Lung cancer is the most common neoplasm diagnosed worldwide. Metastatic presentation of the disease is frequent. Apart from the usual sites of metastatic disease (bone, adrenals, liver, brain), a particular site for metastases is represented by skin. The case we report is about a 66 year-old man with cutaneous metastasis from lung cancer. A 66 year-old man, with a previous history of abdominal aortic aneurism, chronic obstructive pulmonary disease, cardiopathy, diabetes mellitus, was admitted to our institution for left lower lobe lung cancer. After accurate preoperative staging, patient underwent a thoracotomic left lower lobectomy. Histological examination revealed a squamocellular carcinoma: G2-3, pT2bN0. Patient underwent oncological evaluation for the scheduled follow up. After 6 months patient went back to our observation for the appearance of a skin nodule, firm, dischromic, painful and ulcerated, localized in right iliac fossa. Biopsies demonstrated the nodule to be squamocellular carcinoma. Patient underwent a CT scan of the abdomen and thorax, which revealed the absence of infiltration of the deep fascial and muscular planes by the neoplasm. Patient underwent surgical removal of the lesion. Final histological examination confirmed the lesion to be metastasis of squamocellular lung cancer. Metastases from lung cancer occur in about 2,5-7,5% of cases. Median survival for these patients is 2,9 months. The most common type of neoplasm, according to Japanese Authors, is adenocarcinoma followed by squamocellular carcinoma. Some studies demonstrated the adequacy of surgery followed by chemotherapy, in case of single lesion. In case of multiple cutaneous metastases, many Authors suggest only chemotherapy, although the ideal scheme hasn't been discovered yet. Cutaneous metastases from lung cancer are rare; however the appearance of skin lesions, in patients with a positive oncological history, requires much attention. Accurate evaluation of the patient is paramount in choosing the adequate therapeutic algorithm.
  
  
  BACKGROUND
  Chemotherapy, Lung Cancer, Skin Metastases.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Fratus
authors.forename: Fabio
authors.initials: F
authors.lastname: Tagliabue
authors.forename: Pierpaolo
authors.initials: P
authors.lastname: Mariani
authors.forename: Enrico Coppola
authors.initials: EC
authors.lastname: Bottazzi
authors.forename: Luisella
authors.initials: L
authors.lastname: Spinelli
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Novellino
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000556:secondary*; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D012878:Skin Neoplasms / Q000556:secondary*