title: Study on one-pot four-component synthesis of 9-aryl-hexahydro-acridine-1,8-diones using SiO2-I as a new heterogeneous catalyst and their anticancer activity.
abstract: A simple, efficient and cost-effective method for the synthesis of 9-aryl-hexahydro-acridine-1,8-diones by a one-pot four-component cyclocondensation of dimedone, aromatic aldehydes and ammonium acetate as a nitrogen source in the presence of a new heterogeneous catalyst silica iodide (SiO2-I) in EtOH at 80 °C is described. SiO2-I was subjected to SEM-EDX and found to have iodo group bound to the catalyst. Some of the prepared acridine-diones were found to exhibit promising anti-cancer activity against HepG2 and MCF-7 cell lines.
authors.affiliation: Department of Studies in Chemistry, Central College Campus, Palace Road, Bangalore University, Bengaluru 560001, India.
authors.forename: K B
authors.initials: KB
authors.lastname: Ramesh
authors.affiliation: Department of Studies in Chemistry, Central College Campus, Palace Road, Bangalore University, Bengaluru 560001, India. Electronic address: m_af_pasha@ymail.com.
authors.forename: M A
authors.initials: MA
authors.lastname: Pasha
mesh_terms: D000166:Acridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002384:Catalysis; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D056945:Hep G2 Cells; D006801:Humans; D007455:Iodine / Q000737:chemistry*; D061986:MCF-7 Cells; D015394:Molecular Structure; D012822:Silicon Dioxide / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000166:Acridines; D000970:Antineoplastic Agents; D012822:Silicon Dioxide; D007455:Iodine
keywords: 9-Aryl-hexahydro-acridine-1,8-diones; Ammonium acetate; Anticancer activity; Aromatic aldehydes; Dimedone; Silica iodide