title: The antifungal metabolites obtained from the rhizospheric Aspergillus sp. YIM PH30001 against pathogenic fungi of Panax notoginseng.
abstract: Eight anthraquinones (1-8), three xanthones (11-13) and two phenols (9-10) were isolated from Aspergillus sp. associated with Panax notoginseng, and their structures were determined as ziganein-1-methyl ether (1), 8-O-methylchrysophanol (2), averythrin (3), averufin (4), 8-O-methyl averufin (5), versicolorin B (6), averantin (7), methyl-averantin (8), arugosin C (9), diorcinol (10), sterigmatocystin (11), demethylsterigmatocystin (12) and dihydrosterigmatocystin (13) by spectroscopic analyses. Compounds 1, 2 and 5 were the novel isolates from genus Aspergillus. Compounds 3, 6 and 7 exhibited antifungal activity against Fusariumsolani, pathogenic fungus of P. notoginseng, with minimum inhibitory concentrations (MICs) of 16-32 μg/mL, and compounds 1, 3, 4, 7 and 9 showed antibacterial activity against Bacillussubtilis with MICs of 64-128 μg/mL, 16-32 μg/mL, 8-16 μg/mL, 16-32 μg/mL and 64-128 μg/mL, respectively. The metabolites showed the potential value in the research of antifungal agents, especially in searching for a biocontrol of diseases of P. notoginseng. The preliminary structure-activity relationships have been discussed for some of the compounds.
authors.affiliation: a Key Laboratory of Microbial Diversity in Southwest China of Ministry of Education and Laboratory for Conservation and Utilization of Bio-Resources , Yunnan Institute of Microbiology, Yunnan University , Kunming 650091 , P.R. China.
authors.forename: Kai
authors.initials: K
authors.lastname: Liu
authors.forename: Youkun
authors.initials: Y
authors.lastname: Zheng
authors.forename: Cuiping
authors.initials: C
authors.lastname: Miao
authors.forename: Zijun
authors.initials: Z
authors.lastname: Xiong
authors.forename: Lihua
authors.initials: L
authors.lastname: Xu
authors.forename: Huilin
authors.initials: H
authors.lastname: Guan
authors.forename: Yabin
authors.initials: Y
authors.lastname: Yang
authors.forename: Lixing
authors.initials: L
authors.lastname: Zhao
mesh_terms: D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology; D001230:Aspergillus / Q000737:chemistry*; D001412:Bacillus subtilis / Q000187:drug effects; D005670:Fusarium / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D053723:Panax notoginseng / Q000382:microbiology*; D013329:Structure-Activity Relationship; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D044004:Xanthones; C024820:averantin; C029856:averufin; C029827:versicolorin C
keywords: Aspergillus sp; anthraquinones; antifungal activities; xanthones