title: Phloroglucinol derivatives present an antidepressant-like effect in the mice tail suspension test (TST).
abstract: The antidepressant-like effects of phloroglucinol and seven synthetic related derivatives were investigated using the tail suspension test (TST) in mice. Compounds 2-methyl-1-[2,4,6-trihydroxy-3-(2-methylpropanoyl)phenyl] propan-l-one (5), 1-(2,4,6-trihydroxyphenyl)ethan-l-one (6), 1-(3-acetyl-2,4,6-trihydroxyphenyl)ethan-l-one (7), 2-methyl-1 -[2,4,6-trihydroxy-3-(2-methylpropanoyl)-5-{ [2,4,6-trihydroxy-3,5-bis(2-methylpropanoyl)phenyl]methyl phenyl] propan-1-one (9) and 1-{3-acetyl-5-[(3,5-diacetyl-2,4,6-trihydroxyphenyl)methyl]-2,4,6-trihydroxyphenyl}ethan-1-one (10), containing acyl groups, decreased the immobile behavior of mice treated orally with equimolar doses of imipramine 20 mg/kg, with no alterations in locomotor activity as assessed by the open-field test. These results suggest that these phloroglucinol derivatives could represent a new molecular model in the search for antidepressant drugs.
authors.forename: Mônica Oliveira
authors.initials: MO
authors.lastname: Duarte
authors.forename: Soraia
authors.initials: S
authors.lastname: Lunardelli
authors.forename: Cíitia Janine
authors.initials: CJ
authors.lastname: Kiekow
authors.forename: Ana Cristina
authors.initials: AC
authors.lastname: Stein
authors.forename: Liz
authors.initials: L
authors.lastname: Müller
authors.forename: Eveline
authors.initials: E
authors.lastname: Stolz
authors.forename: Stela Maris Kuze
authors.initials: SM
authors.lastname: Rates
authors.forename: Grace
authors.initials: G
authors.lastname: Gosmann
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D019417:Hindlimb Suspension; D008297:Male; D051379:Mice; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000928:Antidepressive Agents; D010696:Phloroglucinol