title: The injury and cumulative effects on human skin by UV exposure from artificial fluorescence emission.
abstract: The injury and cumulative effects of UV emission from fluorescence lamp were studied. UV intensity from fluorescence lamp was measured, and human skin samples (hips, 10 volunteers) were exposed to low-dose UV irradiation (three times per week for 13 consecutive weeks). Three groups were examined: control group without UV radiation; low-dose group with a cumulative dose of 50 J cm(-2) which was equivalent to irradiation of the face during indoor work for 1.5 years; and high-dose group with 1000 J cm(-2) cumulative dose equivalent to irradiation of the face during outdoor activities for 1 year. Specific indicators were measured before and after UVA irradiation. The findings showed that extending the low-dose UVA exposure decreased the skin moisture content and increased the transepidermal water loss as well as induced skin color changes (decreased L* value, increased M index). Furthermore, irradiated skin showed an increased thickness of cuticle and epidermis, skin edema, light color and unclear staining collagen fibers in the dermis, and elastic fiber fragmentation. In addition, MMP-1, p53 and SIRT1 expression was also increased. Long-term exposure of low-dose UVA radiation enhanced skin photoaging. The safety of the fluorescent lamp needs our attention.
authors.affiliation: Department of Dermatology, The General Hospital of Air Force, Beijing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Tian
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: TianHui
authors.initials: T
authors.lastname: Niu
authors.forename: CaiHong
authors.initials: C
authors.lastname: Dai
authors.forename: Xiaoxin
authors.initials: X
authors.lastname: Li
authors.forename: Caijuan
authors.initials: C
authors.lastname: Cui
authors.forename: Xinyan
authors.initials: X
authors.lastname: Zhao
authors.forename: Yaping
authors.initials: Y
authors.lastname: E
authors.forename: Hui
authors.initials: H
authors.lastname: Lu
mesh_terms: D005453:Fluorescence; D006801:Humans; D012867:Skin / Q000293:injuries / Q000528:radiation effects*; D014466:Ultraviolet Rays