title: The role of estrogen receptor β in prostate cancer.
abstract: Although androgen receptor (AR) signaling is the main molecular tool regulating growth and function of the prostate gland, estrogen receptor β (ERβ) is involved in the differentiation of prostatic epithelial cells and numerous antiproliferative actions on prostate cancer cells. However, ERβ splice variants have been associated with prostate cancer initiation and progression mechanisms. ERβ is promising as an anticancer therapy and in the prevention of prostate cancer. Herein, we review the recent experimental findings of ERβ signaling in the prostate.
authors.affiliation: Department of Experimental Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Paraskevi
authors.initials: P
authors.lastname: Christoforou
authors.affiliation: Department of Experimental Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Panagiotis F
authors.initials: PF
authors.lastname: Christopoulos
authors.affiliation: Department of Experimental Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Michael
authors.initials: M
authors.lastname: Koutsilieris
mesh_terms: D000818:Animals; D018450:Disease Progression; D047629:Estrogen Receptor beta / Q000378:metabolism*; D006801:Humans; D008297:Male; D011467:Prostate / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000378:metabolism*
chemical_list: D047629:Estrogen Receptor beta