title: The ethics of clinical trials for cancer therapy.
abstract: Cancer clinical trials are intended to evaluate novel interventions and to improve outcomes. Such research depends on the participation of patients seeking the best options for care. The design, conduct, and analysis of trials must therefore be grounded in an ethical framework that respects and protects the interests of clinical trial participants.
authors.affiliation: Division of Medical Oncology, Duke Cancer Institute; Duke Clinical Research Institute, Durham, North Carolina, USA.
authors.forename: Lynn J
authors.initials: LJ
authors.lastname: Howie
authors.affiliation: Duke Cancer Institute, Durham, North Carolina, USA. jeffrey.peppercorn@dm.duke.edu.
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Peppercorn
mesh_terms: D002986:Clinical Trials as Topic / Q000941:ethics*; D006801:Humans; D007258:Informed Consent / Q000941:ethics*; D009369:Neoplasms / Q000628:therapy*; D010358:Patient Participation; D018579:Patient Selection / Q000941:ethics