title: Chelator-free (64)Cu-integrated gold nanomaterials for positron emission tomography imaging guided photothermal cancer therapy.
abstract: Using positron emission tomography (PET) imaging to monitor and quantitatively analyze the delivery and localization of Au nanomaterials (NMs), a widely used photothermal agent, is essential to optimize therapeutic protocols to achieve individualized medicine and avoid side effects. Coupling radiometals to Au NMs via a chelator faces the challenges of possible detachment of the radiometals as well as surface property changes of the NMs. In this study, we reported a simple and general chelator-free (64)Cu radiolabeling method by chemically reducing (64)Cu on the surface of polyethylene glycol (PEG)-stabilized Au NMs regardless of their shape and size. Our (64)Cu-integrated NMs are proved to be radiochemically stable and can provide an accurate and sensitive localization of NMs through noninvasive PET imaging. We further integrated (64)Cu onto arginine-glycine-aspartic acid (RGD) peptide modified Au nanorods (NRs) for tumor theranostic application. These NRs showed high tumor targeting ability in a U87MG glioblastoma xenograft model and were successfully used for PET image-guided photothermal therapy.
authors.forename: Xiaolian
authors.initials: X
authors.lastname: Sun
authors.forename: Xinglu
authors.initials: X
authors.lastname: Huang
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Yan
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.forename: Jinxia
authors.initials: J
authors.lastname: Guo
authors.forename: Orit
authors.initials: O
authors.lastname: Jacobson
authors.forename: Dingbin
authors.initials: D
authors.lastname: Liu
authors.forename: Lawrence P
authors.initials: LP
authors.lastname: Szajek
authors.forename: Wenlei
authors.initials: W
authors.lastname: Zhu
authors.forename: Gang
authors.initials: G
authors.lastname: Niu
authors.forename: Dale O
authors.initials: DO
authors.lastname: Kiesewetter
authors.forename: Shouheng
authors.initials: S
authors.lastname: Sun
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Chen
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D003300:Copper / Q000737:chemistry; D003301:Copper Radioisotopes; D005909:Glioblastoma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy*; D006046:Gold / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D051379:Mice; D049329:Nanostructures / Q000627:therapeutic use; D043942:Nanotubes / Q000737:chemistry; D009842:Oligopeptides / Q000737:chemistry; D010084:Oxidation-Reduction; D010789:Phototherapy / Q000379:methods*; D011092:Polyethylene Glycols / Q000737:chemistry; D049268:Positron-Emission Tomography / Q000379:methods*; D014018:Tissue Distribution
chemical_list: D003301:Copper Radioisotopes; D009842:Oligopeptides; D011092:Polyethylene Glycols; D006046:Gold; D003300:Copper; C047981:arginyl-glycyl-aspartic acid; C029892:cupric chloride