title: Persistent apparent pancreatic β-cell defects in premenarchal PCOS relatives.
abstract: BACKGROUND
  Polycystic ovary syndrome confers an increased risk for type 2 diabetes in affected women as early as adolescence. First-degree relatives (FDRs) of affected women are at increased risk for associated reproductive and metabolic phenotypes.
  
  
  OBJECTIVE
  We sought to prospectively assess insulin sensitivity and secretion and to measure reproductive hormone levels using sensitive techniques.
  
  
  METHODS
  Twelve premenarchal FDR girls and 10 control girls of comparable age, Tanner stage, and body mass index were studied at an academic medical center.
  
  
  METHODS
  Frequently sampled intravenous glucose tolerance tests and oral glucose tolerance tests were performed.
  
  
  METHODS
  Reproductive hormone levels, lipid profiles, glucose tolerance, and frequently sampled iv glucose tolerance test parameters of insulin sensitivity and secretion were investigated.
  
  
  RESULTS
  Disposition index (DI), insulin secretion corrected for insulin sensitivity, was decreased in FDR compared with control girls at baseline (P = .01), independent of dysglycemia. Decreases in DI persisted in FDR girls during the 2-year follow-up (P = .003). T levels were increased (P = .02) in FDR compared with control girls at baseline, but this difference did not persist because T levels increased in control girls.
  
  
  CONCLUSIONS
  DI is decreased in peripubertal FDR girls, and this decrease persists as puberty progresses. These findings suggest that β-cell dysfunction is an early defect in glucose homeostasis preceding decompensation in glucose tolerance in FDR girls. T levels were increased in FDR girls earlier than previously reported, but these changes did not persist, suggesting an earlier onset of pubertal increases in glandular androgen secretion in FDR girls.
authors.affiliation: Division of Endocrinology (L.C.T., N.R.F., W.J.B.), Ann and Robert H. Lurie Children's Hospital of Chicago, and Division of Endocrinology, Metabolism, and Molecular Medicine (A.D.), Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611; Division of Endocrinology, Diabetes, and Metabolism (R.P.), University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706.
authors.forename: Laura C
authors.initials: LC
authors.lastname: Torchen
authors.forename: Naomi R
authors.initials: NR
authors.lastname: Fogel
authors.forename: Wendy J
authors.initials: WJ
authors.lastname: Brickman
authors.forename: Rodis
authors.initials: R
authors.lastname: Paparodis
authors.forename: Andrea
authors.initials: A
authors.lastname: Dunaif
mesh_terms: D000728:Androgens / Q000097:blood / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D002648:Child; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D005190:Family; D005260:Female; D005951:Glucose Tolerance Test; D012739:Gonadal Steroid Hormones / Q000097:blood / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology*; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D008055:Lipids / Q000097:blood; D008137:Longitudinal Studies; D010053:Ovary / Q000378:metabolism; D011085:Polycystic Ovary Syndrome / Q000378:metabolism*; D011446:Prospective Studies; D011627:Puberty / Q000378:metabolism*; D018570:Risk Assessment
chemical_list: D000728:Androgens; D001786:Blood Glucose; D012739:Gonadal Steroid Hormones; D007328:Insulin; D008055:Lipids