title: Chronic bacterial prostatitis: efficacy of short-lasting antibiotic therapy with prulifloxacin (Unidrox®) in association with saw palmetto extract, lactobacillus sporogens and arbutin (Lactorepens®).
abstract: BACKGROUND
  Bacterial prostatitis (BP) is a common condition accounting responsible for about 5-10% of all prostatitis cases; chronic bacterial prostatitis (CBP) classified as type II, are less common but is a condition that significantly hampers the quality of life, (QoL) because not only is it a physical condition but also a psychological distress. Commonly patients are treated with antibiotics alone, and in particular fluoroquinolones are suggested by the European Urology guidelines. This approach, although recommended, may not be enough. Thus, a multimodal approach to the prolonged antibiotic therapy may be helpful.
  
  
  METHODS
  210 patients affected by chronic bacterial prostatitis were enrolled in the study. All patients were positive to Meares-Stamey test and symptoms duration was > 3 months. The purpose of the study was to evaluate the efficacy of a long lasting therapy with a fluoroquinolone in association with a nutraceutical supplement (prulifloxacin 600 mg for 21 days and an association of Serenoa repens 320 mg, Lactobacillus Sporogens 200 mg, Arbutin 100 mg for 30 days). Patients were randomized in two groups (A and B) receiving respectively antibiotic alone and an association of antibiotic plus supplement.
  
  
  RESULTS
  Biological recurrence at 2 months in Group A was observed in 21 patients (27.6%) and in Group B in 6 patients (7.8%). Uropathogens found at the first follow-up were for the majority Gram - (E. coli and Enterobacter spp.). A statistically significant difference was found at the time of the follow-up between Group A and B in the NIH-CPSI questionnaire score, symptoms evidence and serum PSA.
  
  
  CONCLUSIONS
  Broad band, short-lasting antibiotic therapy in association with a nutritional supplement (serenoa repens, lactobacillus sporogens and arbutin) show better control and recurrence rate on patients affected by chronic bacterial prostatitits in comparison with antibiotic treatment alone.
  
  
  BACKGROUND
  NCT02130713. Date of trial Registration: 30/04/2014.
authors.affiliation: Department of Urology, Sapienza Rome University, Rome, Italy. gianmaria.busetto@uniroma1.it.
authors.forename: Gian Maria
authors.initials: GM
authors.lastname: Busetto
authors.forename: Riccardo
authors.initials: R
authors.lastname: Giovannone
authors.forename: Matteo
authors.initials: M
authors.lastname: Ferro
authors.forename: Stefano
authors.initials: S
authors.lastname: Tricarico
authors.forename: Francesco
authors.initials: F
authors.lastname: Del Giudice
authors.forename: Deliu Victor
authors.initials: DV
authors.lastname: Matei
authors.forename: Ottavio
authors.initials: O
authors.lastname: De Cobelli
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Gentile
authors.forename: Ettore
authors.initials: E
authors.lastname: De Berardinis
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001104:Arbutin / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy*; D002908:Chronic Disease; D003131:Combined Modality Therapy; D019587:Dietary Supplements; D004148:Dioxolanes / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D024841:Fluoroquinolones / Q000627:therapeutic use*; D006801:Humans; D007778:Lactobacillus; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use*; D010936:Plant Extracts / Q000627:therapeutic use; D011472:Prostatitis / Q000188:drug therapy*; D012008:Recurrence; D028024:Serenoa; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D004148:Dioxolanes; D024841:Fluoroquinolones; D010879:Piperazines; D010936:Plant Extracts; D001104:Arbutin; C074191:prulifloxacin; C040972:saw palmetto extract