title: [Association between biochemical markers and left ventricular dysfunction in the ST-elevation acute myocardial infarction].
abstract: OBJECTIVE
  The association between biochemical markers and left ventricular ejection fraction in patients with myocardial infarction was not completely studied. Our goal is to study the association between biochemical markers and left ventricular dysfunction in patients with ST-elevation acute myocardial infarction.
  
  
  METHODS
  With an observational and prospective design we included patients with less than 24h ST-elevation myocardial infarction. Leukocytes, glucose, B-type natriuretic peptide and T troponin were measured at admission, and creatine-phosphokinase and creatine-phosphokinase-MB were measured at admission and serially, and correlated with the ejection fraction estimated by echocardiography.
  
  
  RESULTS
  A total of 108 patients were included. The median left ventricular ejection fraction was 48% (interquartile range 41-57). Simple linear regression analysis showed that B-type natriuretic peptide (P=.005), peak creatine-phosphokinase-MB (P=.01), leukocyte count (P=.001) and glucose (P=.033) were inversely and significantly associated with the left ventricular ejection fraction. The other parameters showed no association. B-type natriuretic peptide (P=.01) and peak creatine-phosphokinase-MB (P=.02) were the only two variables significantly associated with the left ventricular ejection fraction in the multiple linear regression analysis. Both markers were significantly associated with a left ventricular ejection fraction < 50%, independently of other clinical variables.
  
  
  CONCLUSIONS
  B-type natriuretic peptide and peak creatine-phosphokinase-MB showed significant association with left ventricular ejection fraction in the acute phase of ST elevation acute myocardial infarction. This association was independent of the presence of other biochemical markers and clinical variables related to ventricular dysfunction.
authors.affiliation: Servicio de Cardiología, Hospital de Alta Complejidad en Red El Cruce-Néstor Kirchner, Florencio Varela, Buenos Aires, Argentina. Electronic address: maxideabreu@gmail.com.
authors.forename: Maximiliano
authors.initials: M
authors.lastname: de Abreu
authors.affiliation: Servicio de Cardiología, Hospital de Alta Complejidad en Red El Cruce-Néstor Kirchner, Florencio Varela, Buenos Aires, Argentina.
authors.forename: Javier
authors.initials: J
authors.lastname: Mariani
authors.affiliation: Servicio de Cardiología, Hospital de Alta Complejidad en Red El Cruce-Néstor Kirchner, Florencio Varela, Buenos Aires, Argentina.
authors.forename: Cristian
authors.initials: C
authors.lastname: Guridi
authors.affiliation: Servicio de Cardiología, Hospital de Alta Complejidad en Red El Cruce-Néstor Kirchner, Florencio Varela, Buenos Aires, Argentina.
authors.forename: Gabriel
authors.initials: G
authors.lastname: González-Villa-Monte
authors.affiliation: Servicio de Cardiología, Hospital de Alta Complejidad en Red El Cruce-Néstor Kirchner, Florencio Varela, Buenos Aires, Argentina.
authors.forename: Natalio
authors.initials: N
authors.lastname: Gastaldello
authors.affiliation: Servicio de Cardiología, Hospital de Alta Complejidad en Red El Cruce-Néstor Kirchner, Florencio Varela, Buenos Aires, Argentina.
authors.forename: Mauricio
authors.initials: M
authors.lastname: Potito
authors.affiliation: Servicio de Cardiología, Hospital de Alta Complejidad en Red El Cruce-Néstor Kirchner, Florencio Varela, Buenos Aires, Argentina.
authors.forename: Graciela
authors.initials: G
authors.lastname: Reyes
authors.affiliation: Servicio de Cardiología, Hospital de Alta Complejidad en Red El Cruce-Néstor Kirchner, Florencio Varela, Buenos Aires, Argentina.
authors.forename: Laura
authors.initials: L
authors.lastname: Antonietti
authors.affiliation: Servicio de Cardiología, Hospital de Alta Complejidad en Red El Cruce-Néstor Kirchner, Florencio Varela, Buenos Aires, Argentina.
authors.forename: Carlos
authors.initials: C
authors.lastname: Tajer
mesh_terms: D015415:Biomarkers / Q000097:blood; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D011446:Prospective Studies; D018487:Ventricular Dysfunction, Left / Q000097:blood* / Q000150:complications
chemical_list: D015415:Biomarkers
keywords: Acute coronary syndrome; Argentina; Biochemical markers; Disfunción ventricular izquierda; Infarto de miocardio; Left ventricular dysfunction; Marcadores bioquímicos; Myocardial infarction; Síndrome coronario agudo