title: Testicular development of male mice offsprings exposed to acrylamide and alcohol during the gestation and lactation period.
abstract: Acrylamide (Ac) in the foods and alcohol (Al) in the drinks are unavoidable. Several previous studies demonstrated that these substances which are taken into the body via diet may cause adverse effects in the cells. However, there is no study about how Ac and Al may affect the male reproductive system of the offspring when consumed by the mother during pregnancy and lactation. For this purpose, sexual development in male mice was evaluated after intake of 14 mg/kg Ac and 2 g/kg Al from gestation day 6 to postnatal day (PND) 21. The weight of the offspring was reduced at birth and PND 21 for those exposed to Ac and/or Al. The gonadosomatic index of male offsprings was reduced except for the Ac-treated lactation group. Both substances induced multinuclear giant cells, degenerative cells, atrophic tubules, and maturation-arrested tubules, while decreased Leydig, Sertoli, and spermatogenic cell numbers. Lipid peroxidation level and superoxide dismutase enzyme activity increased in both Al-treated and Ac and Al-treated groups. There was only reduction in the catalase activity during the gestation and lactation periods. These findings suggest that consumption of Ac together with Al may induce impairments on testicular spermatogenesis in male offsprings.
authors.affiliation: Department of Biology, Faculty of Science, Istanbul University, Vezneciler, Istanbul, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Şen
authors.affiliation: Department of Biology, Faculty of Science, Istanbul University, Vezneciler, Istanbul, Turkey.
authors.forename: Y
authors.initials: Y
authors.lastname: Tunali
authors.affiliation: Department of Biology, Faculty of Science, Istanbul University, Vezneciler, Istanbul, Turkey merkan@istanbul.edu.tr.
authors.forename: M
authors.initials: M
authors.lastname: Erkan
mesh_terms: D020106:Acrylamide / Q000633:toxicity*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002374:Catalase / Q000378:metabolism; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D007774:Lactation; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008431:Maternal-Fetal Exchange; D008807:Mice, Inbred BALB C; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013076:Sperm Count; D013094:Spermatozoa / Q000166:cytology / Q000187:drug effects; D013482:Superoxide Dismutase / Q000378:metabolism; D013737:Testis / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology
chemical_list: D020106:Acrylamide; D000431:Ethanol; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase
keywords: Acrylamide; alcohol; developmental exposure; oxidative stress; testicular toxicity