title: Solitary fibrous tumor of the kidney with focus on clinical and pathobiological aspects.
abstract: Renal solitary fibrous tumor (SFT) is a rare, and a large scale study on this topic is lacking to date. In this article, we summarize the previously reported cases. The symptoms and signs resemble those of renal cell carcinoma, including hematuria, flank/abdominal/lumbar pain and palpable abdominal mass. Grossly, the tumor demonstrates a well-circumscribed solid mass. Microscopically, the tumor consists of fusiform or ovoid spindle cells and a various amounts of collagen bundles with patternless, storiform, or fascicular arrangements with an occasional hemangiopericytomatous pattern. Immunohistochemically, CD34, CD99 and bcl-2 are often detected. Ultrastructurally, tumor cells contain irregular nuclei, prominent Golgi apparatus, branching rough endoplasmic reticulum, variable numbers of mitochondria. Surgical resection is considered to be the gold standard therapy. Most of renal SFT are benign, but cases of approximately 10 to 15% behave in an aggressive fashion. All patients need to be on long-term follow-up because clinical behavior is rather unpredictable. As the molecular genetic study of renal SFTs is lacking, a large scale study will be desirable in the future.
authors.affiliation: Department of Diagnostic Pathology, Kochi Red Cross Hospital Kochi, Japan.
authors.forename: Naoto
authors.initials: N
authors.lastname: Kuroda
authors.affiliation: Department of Pathology, Kansai Medical University Hirakata Hospital Osaka, Japan.
authors.forename: Chisato
authors.initials: C
authors.lastname: Ohe
authors.affiliation: Department of Pathology, Kansai Medical University Hirakata Hospital Osaka, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Sakaida
authors.affiliation: Department of Pathology, Kansai Medical University Hirakata Hospital Osaka, Japan.
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Uemura
authors.affiliation: Department of Urology, Kochi Medical School, Kochi University Kochi, Japan.
authors.forename: Keiji
authors.initials: K
authors.lastname: Inoue
authors.affiliation: Division of Diagnostic Pathology, Tokyo Women's Medical University Hospital Tokyo, Japan.
authors.forename: Yoji
authors.initials: Y
authors.lastname: Nagashima
authors.affiliation: Department of Pathology, Charles University in Prague, Faculty of Medicine in Plzen Czech Republic.
authors.forename: Ondrej
authors.initials: O
authors.lastname: Hes
authors.affiliation: Department of Pathology, Charles University in Prague, Faculty of Medicine in Plzen Czech Republic.
authors.forename: Michal
authors.initials: M
authors.lastname: Michal
mesh_terms: D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology*; D054364:Solitary Fibrous Tumors / Q000473:pathology*
keywords: CD34; STAT6; Solitary fibrous tumor; kidney