title: Late-onset radiation-induced vasculopathy and stroke in a child with medulloblastoma.
abstract: We report a case of a 15-year-old boy who presented to our institution with left-sided weakness and slurred speech. He had a history of medulloblastoma diagnosed at 3 years of age, status postsurgical resection and craniospinal radiation. Magnetic resonance imaging (MRI) of brain revealed a right paramedian pontine infarction, suspected secondary to late-onset radiation-induced vasculopathy of the vertebrobasilar system. Radiation to the brain is associated with increased incidence of ischemic stroke. Clinicians should have a high index of suspicion for stroke when these patients present with new neurologic symptoms.
authors.affiliation: Division of Child Neurology, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, PA, USA drlalitbansal@hotmail.com.
authors.forename: Lalit R
authors.initials: LR
authors.lastname: Bansal
authors.affiliation: Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Belair
authors.affiliation: Division of Child Neurology, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
authors.forename: Dana
authors.initials: D
authors.lastname: Cummings
authors.affiliation: Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
authors.forename: Giulio
authors.initials: G
authors.lastname: Zuccoli
mesh_terms: D000293:Adolescent; D020526:Brain Stem Infarctions / Q000175:diagnosis* / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D002528:Cerebellar Neoplasms / Q000532:radiotherapy / Q000601:surgery; D002560:Cerebrovascular Circulation / Q000528:radiation effects*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008527:Medulloblastoma / Q000532:radiotherapy* / Q000601:surgery; D011832:Radiation Injuries / Q000150:complications* / Q000175:diagnosis
keywords: brain tumor; radiation; vasculopathy