title: Toxic myopathies.
abstract: Muscle tissue is highly sensitive to many substances. Early recognition of toxic myopathies is important, because they potentially are reversible on removal of the offending drug or toxin, with greater likelihood of complete resolution the sooner this is achieved. Clinical features range from mild muscle pain and cramps to severe weakness with rhabdomyolysis, renal failure, and even death. The pathogenic bases can be multifactorial. This article reviews some of the common toxic myopathies and their clinical presentation, histopathologic features, and possible underlying cellular mechanisms.
authors.affiliation: Department of Neurology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA. Electronic address: mpasnoor@kumc.edu.
authors.forename: Mamatha
authors.initials: M
authors.lastname: Pasnoor
authors.affiliation: Department of Neurology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Barohn
authors.affiliation: Department of Neurology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.
authors.forename: Mazen M
authors.initials: MM
authors.lastname: Dimachkie
mesh_terms: D000924:Anticholesteremic Agents / Q000009:adverse effects*; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D009135:Muscular Diseases / Q000139:chemically induced* / Q000175:diagnosis; D015742:Propofol / Q000009:adverse effects; D014118:Toxins, Biological / Q000009:adverse effects
chemical_list: D000924:Anticholesteremic Agents; D007166:Immunosuppressive Agents; D014118:Toxins, Biological; D003402:Creatine Kinase; D015742:Propofol
keywords: Muscle tissue; Myopathy; Statins; Toxic myopathies