title: Diagnosis and monitoring of postoperative recurrence in Crohn's disease.
abstract: Despite advances in medical management, many patients with Crohn's disease (CD) require intestinal surgery throughout their lives. Surgery is not a cure, and postoperative recurrence is common in patients with CD. Ileocolonoscopy has been considered to be the gold standard in the diagnosis and monitoring of postoperative recurrence. However, the optimal monitoring strategy for postoperative recurrence has yet to be established. Capsule endoscopy and cross-sectional imaging techniques, including ultrasonography, computed tomography and MRI, have been used in the postoperative setting, and their usefulness in the monitoring of disease activity has been evaluated in recent clinical trials. The value of fecal markers, such as calprotectin and lactoferrin, has been also assessed in several studies. This review was to identify optimized methods for the diagnosis and monitoring of postoperative recurrence in CD.
authors.affiliation: Inflammatory Bowel Disease Center and Department of Surgery, Yokkaichi Hazu Medical Center, Yokkaichi, Mie, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Yamamoto
mesh_terms: D015415:Biomarkers / Q000032:analysis; D053704:Capsule Endoscopy; D003113:Colonoscopy; D003424:Crohn Disease / Q000175:diagnosis / Q000378:metabolism / Q000601:surgery*; D003952:Diagnostic Imaging / Q000379:methods; D013505:Digestive System Surgical Procedures / Q000009:adverse effects*; D019160:Endosonography; D005243:Feces / Q000737:chemistry; D006801:Humans; D008279:Magnetic Resonance Imaging; D011237:Predictive Value of Tests; D011877:Radionuclide Imaging; D012008:Recurrence; D012720:Severity of Illness Index; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers
keywords: Crohn’s disease; MRI; capsule endoscopy; computed tomography; fecal calprotectin; fecal lactoferrin; ileocolonoscopy; postoperative recurrence; surgery; ultrasonography