title: Clinical significance of low-positive histoplasma urine antigen results.
abstract: Histoplasma urine antigen (UAg) detection is an important biomarker for histoplasmosis. The clinical significance of low-positive (<0.6 ng/ml) UAg results was evaluated in 25 patients without evidence of prior Histoplasma infection. UAg results from 12/25 (48%) patients were considered falsely positive, suggesting that low-positive UAg values should be interpreted cautiously.
authors.affiliation: Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA theel.elitza@mayo.edu.
authors.forename: Elitza S
authors.initials: ES
authors.lastname: Theel
authors.affiliation: Division of Infectious Diseases, Mayo Clinic Health System, Eau Claire, Wisconsin, USA.
authors.forename: Poornima
authors.initials: P
authors.lastname: Ramanan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000946:Antigens, Fungal / Q000652:urine*; D002648:Child; D005189:False Positive Reactions; D005260:Female; D006658:Histoplasma / Q000737:chemistry*; D006660:Histoplasmosis / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014556:Urine / Q000737:chemistry*
chemical_list: D000946:Antigens, Fungal