title: Molecular parameters and transmembrane transport mechanism of imidazolium-functionalized binols.
abstract: We describe the molecular parameters governing the transmembrane activity of imidazolium-functionalized anion transporters and present a detailed mechanistic study. These ionophores adopt a mobile-carrier mechanism for short methyl and butyl chains, a combined mobile-carrier/transmembrane-pore mechanism for octyl and dodecyl chains, and form transmembrane aggregates for hexadecyl chains.
authors.affiliation: Departement de Chimie, Université de Montréal, C. P. 6128 Succursale Centre-Ville, Montréal, Québec, H3C 3J7 (Canada), Fax: (+1) 514-343-7586.
authors.forename: Marc
authors.initials: M
authors.lastname: Vidal
authors.forename: Andreea
authors.initials: A
authors.lastname: Schmitzer
mesh_terms: D000838:Anions / Q000378:metabolism; D001692:Biological Transport; D019793:Fluorescein / Q000378:metabolism; D007093:Imidazoles / Q000737:chemistry / Q000378:metabolism*; D017136:Ion Transport; D007476:Ionophores / Q000737:chemistry / Q000378:metabolism*; D008051:Lipid Bilayers / Q000378:metabolism*; D008081:Liposomes / Q000378:metabolism*; D009284:Naphthols / Q000737:chemistry / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism
chemical_list: D000838:Anions; C406944:BINOL, naphthol; D007093:Imidazoles; D007476:Ionophores; D008051:Lipid Bilayers; D008081:Liposomes; D009284:Naphthols; D010743:Phospholipids; C029899:imidazole; D019793:Fluorescein
keywords: anion binding; binol; cell membranes; imidazolium salts; transmembrane transporters