title: Her-2 positive gastric cancer presented with thrombocytopenia and skin involvement: a case report.
abstract: Gastric cancer is the 5th most frequent cancer around the world and the 3rd most frequent reason of deaths due to cancer. Every year, about 1 million new cases are taking place, with varying geographical distribution. Gastric cancer is often metastatic to liver, lungs, and bones in hematogenous way, to peripheral lymph nodes in lymphogenous way, and to peripheral tissues in adjacency way, yet bone marrow (BM) and cutaneous metastasis are quite seldom. Pancytopenia is a more frequent finding identified in BM metastasis of solid organ cancers, and isolated thrombocytopenia is less often. The human epidermal growth factor 2 (HER-2) is positive in gastric cancer at a rate of 7-34%. Here, we have presented our HER-2 positive gastric cancer incident which presented with BM and cutaneous metastasis, and has no 18F-fluoro-2-deoxi-D-glucose (FDG) involvement except bone metastases.
authors.affiliation: Department of Medical Oncology, Faculty of Medicine, Akdeniz University, 0700 Antalya, Turkey.
authors.forename: Deniz
authors.initials: D
authors.lastname: Arslan
authors.affiliation: Department of Medical Oncology, Faculty of Medicine, Afyon Kocatepe University, Izmir Karayolu 8.km, 03200 Afyon, Turkey.
authors.forename: Mukremin
authors.identifier: 0000-0002-8524-0665
authors.initials: M
authors.lastname: Uysal
authors.affiliation: Department of Medical Oncology, Faculty of Medicine, Akdeniz University, 0700 Antalya, Turkey.
authors.forename: Ali Murat
authors.initials: AM
authors.lastname: Tatlı
authors.affiliation: Department of Medical Oncology, Faculty of Medicine, Akdeniz University, 0700 Antalya, Turkey.
authors.forename: Seyda
authors.identifier: 0000-0002-6658-6345
authors.initials: S
authors.lastname: Gunduz
authors.affiliation: Department of Medical Oncology, Faculty of Medicine, Akdeniz University, 0700 Antalya, Turkey.
authors.forename: Sema Sezgin
authors.initials: SS
authors.lastname: Goksu
authors.affiliation: Department of Medical Oncology, Faculty of Medicine, Akdeniz University, 0700 Antalya, Turkey.
authors.forename: Cumhur İbrahim
authors.initials: Cİ
authors.lastname: Başsorgun
authors.affiliation: Department of Medical Oncology, Faculty of Medicine, Akdeniz University, 0700 Antalya, Turkey.
authors.forename: Hasan Senol
authors.initials: HS
authors.lastname: Coskun
authors.affiliation: Department of Medical Oncology, Faculty of Medicine, Akdeniz University, 0700 Antalya, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Bozcuk
authors.affiliation: Department of Medical Oncology, Faculty of Medicine, Akdeniz University, 0700 Antalya, Turkey.
authors.forename: Burhan
authors.initials: B
authors.lastname: Savaş