title: N-trifluoromethylthiosaccharin: an easily accessible, shelf-stable, broadly applicable trifluoromethylthiolating reagent.
abstract: A new, electrophilic trifluoromethylthiolating reagent, N-trifluoromethylthiosaccharin, was developed and can be synthesized in two steps from saccharin within 30 minutes. N-trifluoromethylthiosaccharin is a powerful trifluoromethylthiolating reagent and allows the trifluoromethylthiolation of a variety of nucleophiles such as alcohols, amines, thiols, electron-rich arenes, aldehydes, ketones, acyclic β-ketoesters, and alkynes under mild reaction conditions.
authors.affiliation: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (China).
authors.forename: Chunfa
authors.initials: C
authors.lastname: Xu
authors.forename: Bingqing
authors.initials: B
authors.lastname: Ma
authors.forename: Qilong
authors.initials: Q
authors.lastname: Shen
mesh_terms: D015394:Molecular Structure; D012439:Saccharin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: C000598006:N-trifluoromethylthiosaccharin; D013438:Sulfhydryl Compounds; D012439:Saccharin
keywords: NMR spectroscopy; electrophilic substitution; fluorine; sulfur; synthetic methods