title: Associations between apolipoprotein E genotypes and serum levels of glucose, cholesterol, and triglycerides in a cognitively normal aging Han Chinese population.
abstract: OBJECTIVE
  To determine the associations between apolipoprotein E (APOE) genotypes and serum levels of glucose, total cholesterol, and triglycerides in a cognitively normal aging Han Chinese population.
  
  
  METHODS
  There were 1,003 cognitively normal aging subjects included in this study. APOE genotypes were analyzed and biochemical parameters were tested. All the subjects were divided into three groups according to APOE genotypes: (1) E2/2 or E2/3 (APOE E2); (2) E3/3 (APOE E3); and (3) E2/4, E3/4, or E4/4 (APOE E4). Correlations of serum levels of glucose, total cholesterol, and triglycerides with APOE genotypes were assessed.
  
  
  RESULTS
  E2, E3, and E4 allele frequencies were found to be 6.2%, 82.1%, and 11.7%, respectively. Serum levels of total cholesterol were higher in the APOE E4 group (P<0.05). A higher level of total cholesterol was associated with the E4 allele (adjusted odds ratio 1.689, 95% confidence interval 1.223-2.334, P<0.01). However, no association was found between APOE status and serum levels of glucose (adjusted odds ratio 0.981, 95% confidence interval 0.720-1.336, P=0.903) or total triglycerides (adjusted odds ratio 1.042, 95% confidence interval 0.759-1.429, P=0.800).
  
  
  CONCLUSIONS
  A higher serum level of total cholesterol was significantly correlated with APOE E4 status in a cognitively normal, nondiabetic aging population. However, there was no correlation between APOE genotypes and serum levels of glucose or total triglycerides.
authors.affiliation: Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
authors.forename: Qing-Qing
authors.initials: QQ
authors.lastname: Tao
authors.affiliation: Department of Neurology, Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, People's Republic of China ; Department of Medicine, Shanghai Fengxian District Central Hospital, Shanghai, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
authors.forename: Zhi-Jun
authors.initials: ZJ
authors.lastname: Liu
authors.affiliation: Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
authors.forename: Yi-Min
authors.initials: YM
authors.lastname: Sun
authors.affiliation: Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
authors.forename: Ping
authors.initials: P
authors.lastname: Yang
authors.affiliation: Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
authors.forename: Shen-Ji
authors.initials: SJ
authors.lastname: Lu
authors.affiliation: Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
authors.forename: Miao
authors.initials: M
authors.lastname: Xu
authors.affiliation: Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
authors.forename: Qin-Yun
authors.initials: QY
authors.lastname: Dong
authors.affiliation: Department of Neurology, Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, People's Republic of China.
authors.forename: Jia-Jun
authors.initials: JJ
authors.lastname: Yang
authors.affiliation: Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
authors.forename: Zhi-Ying
authors.initials: ZY
authors.lastname: Wu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics / Q000378:metabolism; D053327:Apolipoprotein E4 / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D001786:Blood Glucose / Q000235:genetics* / Q000378:metabolism; D002784:Cholesterol / Q000097:blood*; D003071:Cognition / Q000502:physiology*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012016:Reference Values; D014280:Triglycerides / Q000097:blood*
chemical_list: D053327:Apolipoprotein E4; D001786:Blood Glucose; D014280:Triglycerides; D002784:Cholesterol
keywords: APOE; Alzheimer’s disease; cholesterol; glucose level; triglycerides