title: Vitamin E: a potential therapy for gastric mucosal injury.
abstract: BACKGROUND
  Many scientific reports have shown the involvement of oxidative stress and inflammation as well as diminished gastroprotective substances in the pathogenesis of gastric lesions using various models. Therefore, treatment with antioxidants like tocopherol and tocotrienol may afford beneficial effects in attentuating the formation of the gastric lesions.
  
  
  OBJECTIVE
  The aim of this work was to summarize documented reports on the effects of vitamin E on various models of gastric lesion.
  
  
  METHODS
  A literature search was performed from databases in Medline (PubMed), Web of Science, ScienceDirect, and Googlescholar from June to December 2013.
  
  
  CONCLUSIONS
  The potential roles of tocopherol and tocotrienol in modifying the effects of ulcerogenic agents are discussed in this review. The protective effects of the vitamin E might involve ameliorating oxidative stress and inflammation as well as restoration of endogenous gastroprotective substances. This vitamin has the potential to be used as a therapy for gastric mucosal injury.
authors.affiliation: Department of Pharmacology and.
authors.forename: Yusof
authors.initials: Y
authors.lastname: Kamisah
authors.forename: Haji Mohd Saad
authors.initials: HM
authors.lastname: Qodriyah
authors.forename: Kien Hui
authors.initials: KH
authors.lastname: Chua
authors.forename: Mohd Fahami
authors.initials: MF
authors.lastname: Nur Azlina
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects; D013276:Stomach Ulcer / Q000473:pathology / Q000517:prevention & control; D024505:Tocopherols / Q000494:pharmacology*; D024508:Tocotrienols / Q000494:pharmacology*
chemical_list: D000897:Anti-Ulcer Agents; D000975:Antioxidants; D024508:Tocotrienols; D024505:Tocopherols
keywords: Gastric lesion; inflammation; oxidative stress; stress hormones; tocopherol; tocotrienol