title: Carbolithiation of chloro-substituted alkynes: a new access to vinyl carbenoids.
abstract: The intramolecular carbolithiation of a series of chloro-substituted alkynes leads to exocyclic alkylidene carbenoids of which both nucleophilic and electrophilic characters can be drove. A sole stereoselective 5-exo-dig addition takes place, probably because of a strong and persisting Li-Cl interaction arising before the transition state.
authors.affiliation: Laboratoire COBRA, CNRS UMR 6014 & FR 3038, Univ. Rouen, INSA Rouen, 76821 Mt St Aignan Cedex (France).
authors.forename: Rudy
authors.initials: R
authors.lastname: Lhermet
authors.forename: Maha
authors.initials: M
authors.lastname: Ahmad
authors.forename: Catherine
authors.initials: C
authors.lastname: Fressigné
authors.forename: Bernard
authors.initials: B
authors.lastname: Silvi
authors.forename: Muriel
authors.initials: M
authors.lastname: Durandetti
authors.forename: Jacques
authors.initials: J
authors.lastname: Maddaluno
keywords: carbolithiation; chloroalkyne; heterocycles; lithium; vinyl carbenoids