title: Longitudinal analysis of VP7 gene of group A human rotavirus G2P[4] strains circulating in the pre-vaccine era in Sapporo, Japan from 1991 to 2011.
abstract: Sequence analysis of the VP7 gene in 23 group A human rotavirus G2P[4] strains obtained during 1991-2011, that is, the pre-vaccine era, in Sapporo, Japan showed considerable genetic diversity, mainly in variable regions. Recent G2P[4] epidemic strains were located in sublineage IVa with a distinctive substitution of D96N. This study provides background data on the genetic variability of G2P[4] rotavirus-VP7 gene prior to the widespread use of rotavirus vaccines in Japan.
authors.affiliation: Department of Pediatrics, Sapporo Medical University School of Medicine, South-1, West-16, Sapporo, 060-8543, Japan; Otaru Kyokai Hospital, Otaru City, Japan.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Tatsumi
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Nagaoka
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tsugawa
authors.forename: Yuko
authors.initials: Y
authors.lastname: Yoto
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Hori
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsutsumi
mesh_terms: D000595:Amino Acid Sequence; D000956:Antigens, Viral / Q000235:genetics*; D036022:Capsid Proteins / Q000235:genetics*; D005759:Gastroenteritis / Q000453:epidemiology / Q000821:virology*; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008137:Longitudinal Studies; D017720:Molecular Epidemiology; D012401:Rotavirus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D012400:Rotavirus Infections / Q000453:epidemiology / Q000821:virology*; D016415:Sequence Alignment
chemical_list: D000956:Antigens, Viral; D036022:Capsid Proteins; C050779:VP7 protein, Rotavirus
keywords: G2P[4]; VP7; acute gastroenteritis; human rotavirus