title: The rationale of the myo-inositol and D-chiro-inositol combined treatment for polycystic ovary syndrome.
abstract: PCOS is one of the most common endocrine disorders affecting women and it is characterized by a combination of hyper-androgenism, chronic anovulation, and insulin resistance. While a significant progress has recently been made in the diagnosis for PCOS, the optimal infertility treatment remains to be determined. Two inositol isomers, myo-inositol (MI) and D-chiro-inositol (DCI) have been proven to be effective in PCOS treatment, by improving insulin resistance, serum androgen levels and many features of the metabolic syndrome. However, DCI alone, mostly when it is administered at high dosage, negatively affects oocyte quality, whereas the association MI/DCI, in a combination reproducing the plasma physiological ratio (40:1), represents a promising alternative in achieving better clinical results, by counteracting PCOS at both systemic and ovary level.
authors.affiliation: Dept of Experimental Medicine, Systems Biology Group, University La Sapienza, Roma, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Dinicola
authors.forename: Tony T Y
authors.initials: TT
authors.lastname: Chiu
authors.forename: Vittorio
authors.initials: V
authors.lastname: Unfer
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Carlomagno
authors.forename: Mariano
authors.initials: M
authors.lastname: Bizzarri
mesh_terms: D000728:Androgens / Q000097:blood; D000818:Animals; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007294:Inositol / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D007333:Insulin Resistance; D009865:Oocytes / Q000378:metabolism; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy* / Q000503:physiopathology; D013237:Stereoisomerism; D014803:Vitamin B Complex / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D000728:Androgens; D014803:Vitamin B Complex; D007294:Inositol
keywords: embryo; infertility; inositol; oocyte; polycystic ovarian syndrome