title: Acyl-homoserine lactones suppresses IEC-6 cell proliferation and increase permeability of isolated rat colon.
abstract: We investigated to determine whether a variety of acyl-homoserine lactones (AHLs) influences epithelial cell proliferation and mucosal permeability. 3-Oxo-C12-homoserine lactone (HSL) and 3-oxo-C14-HSL significantly suppressed IEC-6 cell proliferation. A significant increase in mucosal permeability was observed in isolated rat colon tissue exposed to C12-HSL, 3-oxo-C12-HSL, and 3-oxo-C14-HSL. These data indicate that AHLs suppress epithelial proliferation and disrupt barrier function in intestinal mucosa.
authors.affiliation: a Research Faculty of Agriculture , Hokkaido University , Sapporo , Japan.
authors.forename: Ga-Hyun
authors.initials: GH
authors.lastname: Joe
authors.forename: Midori
authors.initials: M
authors.lastname: Andoh
authors.forename: Mikako
authors.initials: M
authors.lastname: Nomura
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Iwaya
authors.forename: Jae-Sung
authors.initials: JS
authors.lastname: Lee
authors.forename: Hidehisa
authors.initials: H
authors.lastname: Shimizu
authors.forename: Youhei
authors.initials: Y
authors.lastname: Tsuji
authors.forename: Hideaki
authors.initials: H
authors.lastname: Maseda
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Miyazaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hara
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ishizuka
mesh_terms: D054742:Acyl-Butyrolactones / Q000008:administration & dosage*; D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects*; D003106:Colon / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000187:drug effects; D008297:Male; D010539:Permeability / Q000187:drug effects; D051381:Rats
chemical_list: D054742:Acyl-Butyrolactones
keywords: IEC-6 cell; acyl-homoserine lactone; cell proliferation; intestinal permeability