title: Higher orthostatic heart rate predicts mortality: The Irish Longitudinal Study on Ageing (TILDA).
abstract: BACKGROUND
  Orthostatic hemodynamic signals may predict adverse outcomes in elders.
  
  
  OBJECTIVE
  To study the association between orthostatic hemodynamics and incident mortality in The Irish Longitudinal Study on Ageing (TILDA).
  
  
  METHODS
  Wave 1 subjects underwent an active stand with non-invasive beat-to-beat blood pressure monitoring. We compared wave 1 active stands, dead vs alive in wave 2.
  
  
  RESULTS
  Compared to the 4,415 participants who had not died, the 53 who had died had a higher baseline heart rate [HR mean of 69 vs 65 beats per minute (bpm)] and a higher mean orthostatic HR, especially between 30 and 60 s post-stand (mean of 79 vs 73 bpm). After adjusting for age, sex, baseline HR, mini-mental state examination score and cardiovascular comorbidities and medications, the mean HR between 30 and 60 s post-stand independently predicted mortality (baseline HR did not).
  
  
  CONCLUSIONS
  Higher early orthostatic HR may be an independent risk marker. Further validation is required.
authors.affiliation: The Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin, Lincoln Gate, Dublin 2, Republic of Ireland, romeror@tcd.ie.
authors.forename: Roman
authors.initials: R
authors.lastname: Romero-Ortuno
authors.forename: Matthew D L
authors.initials: MD
authors.lastname: O'Connell
authors.forename: Ciarán
authors.initials: C
authors.lastname: Finucane
authors.forename: Chie Wei
authors.initials: CW
authors.lastname: Fan
authors.forename: Rose Anne
authors.initials: RA
authors.lastname: Kenny
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology; D015897:Comorbidity; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011187:Posture / Q000502:physiology