title: Anti-aging and anti-microbial effects of melleolide on various types of yeast.
abstract: The chronological lifespan (CLS) of the budding yeast Saccharomyces cerevisiae is a model for the aging of post-mitotic cells in higher eukaryotes. In this study, we found that the sesquiterpene aryl ester melleolide expands the CLS of budding yeast. In contrast, melleolide compromised the CLS of the fission yeast Schizosaccharomyces pombe. This indicates that melleolide might have a potential anti-aging activity against some types of cell, and that it might be useful as a selective anti-fungal drug.
authors.affiliation: a Faculty of Science , Shizuoka University , Shizuoka , Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Nakaya
authors.forename: Hajime
authors.initials: H
authors.lastname: Kobori
authors.forename: Atsushi
authors.initials: A
authors.lastname: Sekiya
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Kawagishi
authors.forename: Takashi
authors.initials: T
authors.lastname: Ushimaru
mesh_terms: D000375:Aging / Q000187:drug effects / Q000235:genetics; D055392:Armillaria / Q000737:chemistry; D015966:Gene Expression Regulation, Fungal / Q000187:drug effects; D008136:Longevity / Q000187:drug effects / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000235:genetics; D012568:Schizosaccharomyces / Q000187:drug effects* / Q000235:genetics; D012717:Sesquiterpenes / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D012717:Sesquiterpenes; C408304:melleolide K
keywords: anti-aging; anti-microbial; budding yeast; fission yeast; melleolide