title: Synthesis of 3,3-disubstituted-2,3-dihydroazanaphthoquinones via simultaneous alkyne oxidation and nitrile hydration of ortho-alkynylarenenitriles.
abstract: o-Alkynylarenenitriles when heated with Pd(OAc)2/H2O/(±)-CSA in DMSO undergo simultaneous alkyne oxidation and nitrile hydration to give 3-aryl-3-hydroxy-2,3-dihydroazanaphthoquinones. Upon treatment with (±)-CSA, these compounds form 3-arylazanaphthoquinones in situ, which add to electron-rich aromatics and terminal alkene/alkyne to afford 3,3-disubstituted-2,3-dihydroazanaphthoquinones.
authors.affiliation: School of Chemistry, Bharathidasan University, Tiruchirappalli-620 024, Tamil Nadu, India. srinivasank@bdu.ac.in.
authors.forename: Karuppusamy
authors.initials: K
authors.lastname: Sakthivel
authors.forename: Kannupal
authors.initials: K
authors.lastname: Srinivasan