title: Practical aerobic oxidations of alcohols and amines with homogeneous copper/TEMPO and related catalyst systems.
abstract: Oxidations of alcohols and amines are common reactions in the synthesis of organic molecules in the laboratory and industry. Aerobic oxidation methods have long been sought for these transformations, but few practical methods exist that offer advantages over traditional oxidation methods. Recently developed homogeneous Cu/TEMPO (TEMPO = 2,2,6,6-tetramethylpiperidinyl-N-oxyl) and related catalyst systems appear to fill this void. The reactions exhibit high levels of chemoselectivity and broad functional-group tolerance, and they often operate efficiently at room temperature with ambient air as the oxidant. These advances, together with their historical context and recent applications, are highlighted in this Minireview.
authors.affiliation: Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706 (USA).
authors.forename: Bradford L
authors.initials: BL
authors.lastname: Ryland
authors.forename: Shannon S
authors.initials: SS
authors.lastname: Stahl
mesh_terms: D000388:Air; D000438:Alcohols / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003497:Cyclic N-Oxides / Q000737:chemistry*; D010084:Oxidation-Reduction
chemical_list: D000438:Alcohols; D000588:Amines; D003497:Cyclic N-Oxides; D003300:Copper; C003959:TEMPO
keywords: aerobic oxidation; alcohols; amines; copper; nitroxyl radicals