title: Gangliogliomas of the optic pathway.
abstract: Gangliogliomas involving the optic apparatus are rare, with only 23 cases described in the literature to our knowledge. Because of their location, they are resistant to gross total resection and command careful consideration of adjuvant treatment. Here, we review the existing literature describing these cases, along with our own additional patient. Most patients (91.3%) with optic gangliogliomas presented with progressive visual disturbances, and the majority were male (69.6%), as with gangliogliomas in general. Ophthalmological evaluation is warranted in these patients, followed by neurological imaging (preferably MRI). Screening for neurofibromatosis type 1 (NF1) is essential, as NF1 patients represent a disproportionate number of optic ganglioglioma cases (13.0%). Gross total resection should be attempted only if vision is beyond salvage, as this can be curative. Otherwise, when serviceable vision remains, subtotal resection with adjuvant radiation should be carried out when feasible. Despite treatment, the prognosis remains mixed, with roughly one-third of patients progressing.
authors.affiliation: Department of Neurological Surgery, University of California, 505 Parnassus Avenue, M779, San Francisco, CA 94143-0112, USA. Electronic address: rolstonj@neurosurg.ucsf.edu.
authors.forename: John D
authors.initials: JD
authors.lastname: Rolston
authors.affiliation: Department of Neurological Surgery, University of California, 505 Parnassus Avenue, M779, San Francisco, CA 94143-0112, USA.
authors.forename: Seunggu J
authors.initials: SJ
authors.lastname: Han
authors.affiliation: Division of Neuropathology, Department of Pathology, University of California, San Francisco, CA, USA.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Cotter
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, University of California, San Francisco, CA, USA.
authors.forename: Ivan H
authors.initials: IH
authors.lastname: El-Sayed
authors.affiliation: Department of Neurological Surgery, University of California, 505 Parnassus Avenue, M779, San Francisco, CA 94143-0112, USA.
authors.forename: Manish K
authors.initials: MK
authors.lastname: Aghi
mesh_terms: D003937:Diagnosis, Differential; D018303:Ganglioglioma / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D019574:Optic Nerve Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery*
keywords: Ganglioglioma; Optic glioma; Pituitary; Sella; Visual loss