title: Cell and tissue engineering for liver disease.
abstract: Despite the tremendous hurdles presented by the complexity of the liver's structure and function, advances in liver physiology, stem cell biology and reprogramming, and the engineering of tissues and devices are accelerating the development of cell-based therapies for treating liver disease and liver failure. This State of the Art Review discusses both the near- and long-term prospects for such cell-based therapies and the unique challenges for clinical translation.
authors.affiliation: Institute for Medical Engineering & Science at MIT, Department of Electrical Engineering and Computer Science, David H. Koch Institute at MIT, and the Howard Hughes Medical Institute, Cambridge, MA 02139, USA. Division of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. sbhatia@mit.edu.
authors.forename: Sangeeta N
authors.initials: SN
authors.lastname: Bhatia
authors.affiliation: Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
authors.forename: Gregory H
authors.initials: GH
authors.lastname: Underhill
authors.affiliation: Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Kenneth S
authors.initials: KS
authors.lastname: Zaret
authors.affiliation: Department of Surgery, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, and McGowan Institute for Regenerative Medicine, Pittsburgh, PA 15224, USA.
authors.forename: Ira J
authors.initials: IJ
authors.lastname: Fox
mesh_terms: D000818:Animals; D060846:Cell Engineering / Q000379:methods*; D004195:Disease Models, Animal; D006801:Humans; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000628:therapy*; D023822:Tissue Engineering / Q000379:methods*; D057170:Translational Research, Biomedical