title: Impact of statin use on exercise-induced cardiac troponin elevations.
abstract: Marathon running commonly causes a transient elevation of creatine kinase and cardiac troponin I (cTnI). The use of statins before marathon running exacerbates the release of creatine kinase from skeletal muscle, but the effect of statin use on exercise-induced cTnI release is unknown. We therefore measured cTnI concentrations in statin-using (n = 30) and nonstatin-using (n = 41) runners who participated in the 2011 Boston Marathon. All runners provided venous blood samples the day before, within an hour of finishing, and 24 hours after the marathon. cTnI was assessed at each time point via both a contemporary cTnI and high-sensitivity cTnI (hsTnI) assay. Before the marathon, cTnI was detectable in 99% of runners with the use of the hsTnI assay. All participants completed the marathon (finish time: 4:04:09 ± 0:41:10), and none had symptoms of an acute coronary syndrome. cTnI increased in all runners (p <0.001) immediately after the marathon, and half (hsTnI = 54% vs contemporary cTnI = 47%) exceeded the diagnostic cut-point for an acute myocardial infarction. Statin use did not affect the magnitude of cTnI release (group*time p = 0.47) or the incidence of runners with cTnI elevation greater than the diagnostic cut-point for myocardial infarction (57% vs 51%, p = 0.65). In addition, there was no significant association between statin potency and cTnI release (r = 0.09, p = 0.65). In conclusion, marathon-induced cTnI increases are not altered by statin use.
authors.affiliation: Henry Low Heart Center, Department of Cardiology, Hartford Hospital, Hartford, Connecticut; Department of Physiology, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Thijs M H
authors.initials: TM
authors.lastname: Eijsvogels
authors.affiliation: Cardiovascular Performance Program, Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts.
authors.forename: James L
authors.initials: JL
authors.lastname: Januzzi
authors.affiliation: Henry Low Heart Center, Department of Cardiology, Hartford Hospital, Hartford, Connecticut; Department of Health Sciences, University of Hartford, West Hartford, Connecticut.
authors.forename: Beth A
authors.initials: BA
authors.lastname: Taylor
authors.affiliation: Cardiovascular Performance Program, Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts.
authors.forename: Stephanie K
authors.initials: SK
authors.lastname: Isaacs
authors.affiliation: Boston Athletic Association, Boston, Massachusetts.
authors.forename: Pierre
authors.initials: P
authors.lastname: D'Hemecourt
authors.affiliation: Henry Low Heart Center, Department of Cardiology, Hartford Hospital, Hartford, Connecticut.
authors.forename: Amanda
authors.initials: A
authors.lastname: Zaleski
authors.affiliation: Boston Athletic Association, Boston, Massachusetts.
authors.forename: Sophia
authors.initials: S
authors.lastname: Dyer
authors.affiliation: Boston Athletic Association, Boston, Massachusetts.
authors.forename: Chris
authors.initials: C
authors.lastname: Troyanos
authors.affiliation: Cardiovascular Performance Program, Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts.
authors.forename: Rory B
authors.initials: RB
authors.lastname: Weiner
authors.affiliation: Henry Low Heart Center, Department of Cardiology, Hartford Hospital, Hartford, Connecticut.
authors.forename: Paul D
authors.initials: PD
authors.lastname: Thompson
authors.affiliation: Cardiovascular Performance Program, Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts; Boston Athletic Association, Boston, Massachusetts. Electronic address: abaggish@partners.org.
authors.forename: Aaron L
authors.initials: AL
authors.lastname: Baggish
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D064368:Healthy Volunteers; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000517:prevention & control*; D011379:Prognosis; D012189:Retrospective Studies; D012420:Running / Q000502:physiology*; D019210:Troponin I / Q000097:blood*; D020107:Troponin T / Q000097:blood*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D019210:Troponin I; D020107:Troponin T