title: Body composition and weight gain in new users of the three-monthly injectable contraceptive, depot-medroxyprogesterone acetate, after 12 months of follow-up.
abstract: OBJECTIVE
  To evaluate weight gain and body composition (BC) in new users of depot-medroxyprogesterone acetate (DMPA) as a contraceptive.
  
  
  METHODS
  This cohort study followed up 20 DMPA users and 20 copper intrauterine device (TCu380A IUD) users, paired for age (± 1 year) and body mass index (BMI ± 1 kg/m(2)), during 12-months. Healthy, non-obese women aged 18 to 40 years, unaffected by conditions that could influence their body weight, were enrolled. Socio-demographic variables, habits, weight, BMI, BC using dual-energy X-ray absorptiometry, circumferences, skinfold thickness, body fat percentage and waist-to-hip ratio were evaluated. All participants were encouraged to adopt healthy habits.
  
  
  RESULTS
  At baseline, median age was 29 and 30.5 years, and mean BMI was 24.8 and 24.5 kg/m(2) in the DMPA and IUD groups, respectively. At 12 months, an increase was observed in waist and hip circumference in the DMPA users and 8/20 of them had a weight gain ≥ 5% (mean 4.6 kg) with accumulation of fat centrally.
  
  
  CONCLUSIONS
  There were no differences in weight gain or in BC measurements between the groups; nevertheless 40% of women in the DMPA group had larger weight gain and accumulation of fat centrally. The duration of follow-up may have been insufficient to detect differences between the groups.
authors.affiliation: * Human Reproduction Unit of the Department of Obstetrics and Gynaecology.
authors.forename: Priscilla de Nazaré Silva
authors.initials: Pde N
authors.lastname: dos  Santos
authors.forename: Waleska Oliveira
authors.initials: WO
authors.lastname: Modesto
authors.forename: Nathalia
authors.initials: N
authors.lastname: Dal'Ava
authors.forename: Maria Valéria
authors.initials: MV
authors.lastname: Bahamondes
authors.forename: Elizabeth João
authors.initials: EJ
authors.lastname: Pavin
authors.forename: Arlete
authors.initials: A
authors.lastname: Fernandes
mesh_terms: D000293:Adolescent; D000328:Adult; D001823:Body Composition / Q000187:drug effects*; D015992:Body Mass Index; D003271:Contraceptive Agents, Female / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007267:Injections; D007434:Intrauterine Devices / Q000009:adverse effects; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage / Q000009:adverse effects*; D015430:Weight Gain / Q000187:drug effects*; D055815:Young Adult
chemical_list: D003271:Contraceptive Agents, Female; D017258:Medroxyprogesterone Acetate
keywords: Body composition; Contraception; Depot-medroxyprogesterone acetate; Weight