title: GnRH agonist trigger and ovarian hyperstimulation syndrome: relook at 'freeze-all strategy'.
abstract: A case is reported of early onset ovarian hyperstimulation syndrome (OHSS) after gonadotrophin-releasing hormone agonist (GnRHa) trigger for final oocyte maturation in a GnRH antagonist protocol. The use of GnRHa in place of HCG as a trigger for final oocyte maturation in an antagonist IVF cycle has been proposed as a method for preventing OHSS in predicted high-responders. This approach, however, did not prevent the occurrence of OHSS in our case despite a freeze-all strategy. To the best of our knowledge, this is a possible index case of severe OHSS with GnRHa trigger for oocyte maturation without any luteal HCG rescue for a high responder, despite IVF cycle segmentation.
authors.affiliation: Department of Reproductive Medicine, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore 229899, Singapore.
authors.forename: Liza Ping
authors.initials: LP
authors.lastname: Ling
authors.affiliation: Department of Reproductive Medicine, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore 229899, Singapore.
authors.forename: Jessie Wai Leng
authors.initials: JW
authors.lastname: Phoon
authors.affiliation: Department of Reproductive Medicine, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore 229899, Singapore.
authors.forename: Matthew Sie Kuei
authors.initials: MS
authors.lastname: Lau
authors.affiliation: Department of Reproductive Medicine, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore 229899, Singapore.
authors.forename: Jerry Kok Yen
authors.initials: JK
authors.lastname: Chan
authors.affiliation: Department of Reproductive Medicine, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore 229899, Singapore.
authors.forename: Veronique
authors.initials: V
authors.lastname: Viardot-Foucault
authors.affiliation: Department of Reproductive Medicine, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore 229899, Singapore.
authors.forename: Tse Yeun
authors.initials: TY
authors.lastname: Tan
authors.affiliation: Department of Reproductive Medicine, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore 229899, Singapore.
authors.forename: Sadhana
authors.initials: S
authors.lastname: Nadarajah
authors.affiliation: Department of Reproductive Medicine, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore 229899, Singapore. Electronic address: tan.heng.hao@kkh.com.sg.
authors.forename: Heng Hao
authors.initials: HH
authors.lastname: Tan
mesh_terms: D000328:Adult; D015925:Cryopreservation; D005260:Female; D005300:Fertility Agents, Female / Q000009:adverse effects*; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D016471:Ovarian Hyperstimulation Syndrome / Q000139:chemically induced*; D010062:Ovulation Induction / Q000009:adverse effects* / Q000379:methods
chemical_list: D005300:Fertility Agents, Female; D007987:Gonadotropin-Releasing Hormone
keywords: AMH level; GnRH agonist; GnRH antagonist protocol; ovarian hyperstimulation syndrome