title: mtDNA sequence, phylogeny and evolution of laboratory mice.
abstract: Laboratory mice are important tools for biomedical research. Aiming to investigate the phylogeny and evolution of laboratory mice, we investigated the mtDNA sequences of classic inbred strains, classic outbred stocks and wild-derived inbred strains. Our results showed that the most classic outbred stocks and classic inbred strains are descended from a single mtDNA ancestor. The phylogenic analysis supports the topology of M. m. castaneus/M. m. domesticus as sister subspecies, and the divergence time between the two sister subspecies and M. m. musculus was 493,000 (435,000-557,000) years ago. Furthermore, the mtDNA polymorphisms accumulated in the last 100years in the laboratory mice are under a relaxed purifying selection.
authors.affiliation: The Medical College of Xiamen University, Xiamen University, 361005 Xiamen, China.
authors.forename: Junfeng
authors.initials: J
authors.lastname: Zheng
authors.affiliation: The Medical College of Xiamen University, Xiamen University, 361005 Xiamen, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: The Medical College of Xiamen University, Xiamen University, 361005 Xiamen, China.
authors.forename: Fengyuan
authors.initials: F
authors.lastname: Deng
authors.affiliation: The Medical College of Xiamen University, Xiamen University, 361005 Xiamen, China.
authors.forename: Renliang
authors.initials: R
authors.lastname: Huang
authors.affiliation: Priority Area Asthma and Allergy, Research Center Borstel, 23845 Borstel, Germany, Airway Research Center North (ARCN), UGMLC, Member of the German Center for Lung Research (DZL).
authors.forename: Frank
authors.initials: F
authors.lastname: Petersen
authors.affiliation: Department of Dermatology, University of Lübeck, 23538 Lübeck, Germany.
authors.forename: Saleh
authors.initials: S
authors.lastname: Ibrahim
authors.affiliation: The Medical College of Xiamen University, Xiamen University, 361005 Xiamen, China; Priority Area Asthma and Allergy, Research Center Borstel, 23845 Borstel, Germany, Airway Research Center North (ARCN), UGMLC, Member of the German Center for Lung Research (DZL). Electronic address: xinhuayu@fz-borstel.de.
authors.forename: Xinhua
authors.initials: X
authors.lastname: Yu
mesh_terms: D000818:Animals; D004272:DNA, Mitochondrial / Q000235:genetics*; D019143:Evolution, Molecular; D005260:Female; D008297:Male; D051379:Mice; D010802:Phylogeny; D011110:Polymorphism, Genetic; D012641:Selection, Genetic
chemical_list: D004272:DNA, Mitochondrial
keywords: Inbred strains; Outbred stock; Phylogenetic history; Relaxed purifying selection; mtDNA