title: In vitro maturation of human oocytes: Its role in infertility treatment and new possibilities.
abstract: IVM refers to the maturation of immature oocytes in culture after their recovery from small antral follicles at the stage prior to selection and dominance. IVM requires little or no FSH in vivo and has been proposed as an alternative to conventional IVF, since it reduces the primary adverse effects caused by controlled ovarian stimulation, including the ovarian hyperstimulation syndrome. Moreover, IVM is a promising option for cases for which no standard protocol is suitable, such as FSH resistance, contraindications for ovarian stimulatory drugs, and the need for urgent fertility preservation. Recently, IVM has been used in women with regular cycles and normal ovaries. However, the pregnancy rate following IVM is suboptimal compared with that of conventional IVF, indicating that further studies to optimize the protocol and the culture conditions are warranted.
authors.affiliation: Department of Obstetrics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University, Seoul, Korea.
authors.forename: Eun Mi
authors.initials: EM
authors.lastname: Chang
authors.affiliation: Department of Biomedical Science, College of Life Science, CHA University, Seoul, Korea.
authors.forename: Hang Seok
authors.initials: HS
authors.lastname: Song
authors.affiliation: Department of Biomedical Science, College of Life Science, CHA University, Seoul, Korea.
authors.forename: Dong Ryul
authors.initials: DR
authors.lastname: Lee
authors.affiliation: Department of Obstetrics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University, Seoul, Korea.
authors.forename: Woo Sik
authors.initials: WS
authors.lastname: Lee
authors.affiliation: Department of Obstetrics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University, Seoul, Korea.
authors.forename: Tae Ki
authors.initials: TK
authors.lastname: Yoon
keywords: Fertility preservation; Follicle culture; In vitro maturation; Infertility; Oocyte