title: Correlation of quantitative texture analysis of cranial ultrasound with later neurobehavior in preterm infants.
abstract: The purpose of the study was to evaluate the association between a quantitative texture analysis of early neonatal brain ultrasound images and later neurobehavior in preterm infants. A prospective cohort study including 120 preterm (<33 wk of gestational age) infants was performed. Cranial ultrasound images taken early after birth were analyzed in six regions of interest using software based on texture analysis. The resulting texture scores were correlated with the Neonatal Behavioural Assessment Scale (NBAS) at term-equivalent age. The ability of texture scores, in combination with clinical data and standard ultrasound findings, to predict the NBAS results was evaluated. Texture scores were significantly associated with all but one NBAS domain and better predicted NBAS results than clinical data and standard ultrasound findings. The best predictive value was obtained by combining texture scores with clinical information and ultrasound standard findings (area under the curve = 0.94). We conclude that texture analysis of neonatal cranial ultrasound-extracted quantitative features that correlate with later neurobehavior has a higher predictive value than the combination of clinical data with abnormalities in conventional cranial ultrasound.
authors.affiliation: Neonatal and Maternal-Fetal Medicine Department, ICGON, Hospital Clınic, Universitat de Barcelona, Barcelona, Spain; Fetal and Perinatal Medicine Research Group, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
authors.forename: Violeta
authors.initials: V
authors.lastname: Tenorio
authors.affiliation: Transmural Biotech SL, Barcelona, Spain.
authors.forename: Elisenda
authors.initials: E
authors.lastname: Bonet-Carne
authors.affiliation: Neonatal and Maternal-Fetal Medicine Department, ICGON, Hospital Clınic, Universitat de Barcelona, Barcelona, Spain; Fetal and Perinatal Medicine Research Group, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Barcelona, Spain.
authors.forename: Francesc
authors.initials: F
authors.lastname: Figueras
authors.affiliation: Neonatal and Maternal-Fetal Medicine Department, ICGON, Hospital Clınic, Universitat de Barcelona, Barcelona, Spain; Fetal and Perinatal Medicine Research Group, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
authors.forename: Francesc
authors.initials: F
authors.lastname: Botet
authors.affiliation: Neonatal and Maternal-Fetal Medicine Department, ICGON, Hospital Clınic, Universitat de Barcelona, Barcelona, Spain; Fetal and Perinatal Medicine Research Group, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
authors.forename: Angela
authors.initials: A
authors.lastname: Arranz
authors.affiliation: Transmural Biotech SL, Barcelona, Spain.
authors.forename: Ivan
authors.initials: I
authors.lastname: Amat-Roldan
authors.affiliation: Neonatal and Maternal-Fetal Medicine Department, ICGON, Hospital Clınic, Universitat de Barcelona, Barcelona, Spain; Fetal and Perinatal Medicine Research Group, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Barcelona, Spain. Electronic address: egratacos@clinic.ub.es.
authors.forename: Eduard
authors.initials: E
authors.lastname: Gratacos
mesh_terms: D000704:Analysis of Variance; D001931:Brain Mapping / Q000379:methods*; D002657:Child Development / Q000502:physiology*; D015331:Cohort Studies; D004453:Echoencephalography / Q000379:methods*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D007223:Infant; D018730:Infant Behavior / Q000502:physiology*; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D011446:Prospective Studies
keywords: Cranial ultrasound; Neurobehavior; Prematurity; Quantitative ultrasound; Texture analysis