title: Antiretroviral restriction factors in mice.
abstract: One of the most exciting areas in contemporary retrovirus research is the discovery of "restriction factors". These are cellular proteins that act after virus entry to inhibit infection by or replication of retroviruses (and other viruses and intracellular pathogens). We briefly discuss here three antiretroviral restriction factors in mice: Fv1, APOBEC3, and tetherin, touching on both biological and molecular aspects of these restriction systems.
authors.affiliation: HIV Drug Resistance Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
authors.forename: Smita
authors.initials: S
authors.lastname: Nair
authors.affiliation: HIV Drug Resistance Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA. Electronic address: reina@mail.nih.gov.
authors.forename: Alan
authors.initials: A
authors.lastname: Rein
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000235:genetics / Q000378:metabolism; D003564:Cytidine Deaminase / Q000235:genetics / Q000378:metabolism; D054884:Host-Pathogen Interactions / Q000276:immunology*; D007113:Immunity, Innate; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism; D051379:Mice; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D012190:Retroviridae / Q000502:physiology*; D012192:Retroviridae Infections / Q000235:genetics / Q000276:immunology* / Q000378:metabolism / Q000821:virology*; D000074010:Bone Marrow Stromal Antigen 2
chemical_list: D015703:Antigens, CD; D003564:Cytidine Deaminase; D008562:Membrane Glycoproteins; D011506:Proteins; C513868:BST2 protein, mouse; D000074010:Bone Marrow Stromal Antigen 2; C103189:Fv1 protein, mouse; C503504:Apobec3 protein, mouse
keywords: APOBEC3; Fv1 restriction; Murine leukemia virus; Retrovirus; Tetherin