title: Salmonella typhimurium with γ-radiation induced H2AX phosphorylation and apoptosis in melanoma.
abstract: To investigate the combinatorial effects using Salmonella and γ-radiation, the Salmonella typhimurium infection in combination with γ-radiation was investigated on melanoma. We showed that ROS expression and H2AX phosphorylation increased during stress by γ-radiation irrespective of Salmonella infection, inducing apoptosis by caspase-3 and bcl2 in tumor cells. In addition, tumor growth was suppressed by this combinatory therapy suggesting candidates for radiation therapy against melanoma.
authors.affiliation: a School of Life Sciences and Biotechnology, Korea University , Seoul , Republic of Korea.
authors.forename: Won Suck
authors.initials: WS
authors.lastname: Yoon
authors.forename: Sinyeon
authors.initials: S
authors.lastname: Kim
authors.forename: Sungchul
authors.initials: S
authors.lastname: Seo
authors.forename: Yongkeun
authors.initials: Y
authors.lastname: Park
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000528:radiation effects*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000528:radiation effects; D005720:Gamma Rays / Q000627:therapeutic use*; D006657:Histones / Q000378:metabolism*; D008545:Melanoma / Q000473:pathology*; D051379:Mice; D010766:Phosphorylation / Q000528:radiation effects; D017382:Reactive Oxygen Species / Q000378:metabolism; D012486:Salmonella typhimurium / Q000502:physiology*
chemical_list: D006657:Histones; D017382:Reactive Oxygen Species
keywords: H2A histone family member (H2AX); Salmonella typhimurium; melanoma; radiotherapy; reactive oxygen species (ROS)