title: Development of C-N coupling using mechanochemistry: catalytic coupling of arylsulfonamides and carbodiimides.
abstract: Reported herein is the mechanochemical synthesis of sulfonyl guanidines, a family of molecules which are relevant as pharmaceuticals and herbicides, by direct coupling of sulfonamides and aromatic or aliphatic carbodiimides. Attempts to conduct the coupling in solution have either failed or given very low conversions, thus demonstrating mechanochemistry as the necessary component for the discovery of this synthetic strategy.
authors.affiliation: Department of Chemistry and FRQNT Centre for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke St. W. H3A 0B8 Montreal (Canada).
authors.forename: Davin
authors.initials: D
authors.lastname: Tan
authors.forename: Cristina
authors.initials: C
authors.lastname: Mottillo
authors.forename: Athanassios D
authors.initials: AD
authors.lastname: Katsenis
authors.forename: Vjekoslav
authors.initials: V
authors.lastname: Štrukil
authors.forename: Tomislav
authors.initials: T
authors.lastname: Friščić
keywords: CN coupling; copper; heterogeneous catalysis; mechanosynthesis; synthetic methods