title: Anti-Müllerian hormone as a possible predictor of fecundability in subfertile women over 38 years: a retrospective cohort study.
abstract: Anti-Müllerian hormone (AMH) is a relatively novel method for examining the ovarian reserve that reflects female reproductive function. In the era in which the number of women delaying attempts to conceive has increased, a good predictor for long-term fecundability has been explored. We performed the retrospective cohort study to investigate whether initial serum AMH levels are useful for predicting long-term fertility during infertility treatments. We recruited 149 women in the retrospective cohort, and 52 women were gravid during the follow-up period. According to the multiple logistic analyses, only age was found to have a significant correlation with pregnancy success in all women. In women ≥38 years, significantly higher serum AMH levels were detected in the pregnant group (median = 2.83 ng/mL, range = 1.11-6.29 ng/mL) than the non-pregnant group (median = 1.22 ng/mL, range = 0-9.46 ng/mL; p = 0.015). None of the women with serum AMH levels <0.7 ng/mL were pregnant during treatment. AMH may be used to identify poor pregnancy prospects in women who are above 38 years.
authors.affiliation: Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine , Nagoya , Japan and.
authors.forename: Nao
authors.initials: N
authors.lastname: Kato
authors.forename: Akira
authors.initials: A
authors.lastname: Iwase
authors.forename: Atsuko
authors.initials: A
authors.lastname: Sugita
authors.forename: Maki
authors.initials: M
authors.lastname: Goto
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Nakahara
authors.forename: Tomoko
authors.initials: T
authors.lastname: Nakamura
authors.forename: Mika
authors.initials: M
authors.lastname: Kondo
authors.forename: Satoko
authors.initials: S
authors.lastname: Osuka
authors.forename: Masahiko
authors.initials: M
authors.lastname: Mori
authors.forename: Ai
authors.initials: A
authors.lastname: Saito
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Kikkawa
mesh_terms: D000328:Adult; D000367:Age Factors; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015331:Cohort Studies; D005260:Female; D005298:Fertility / Q000502:physiology*; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000175:diagnosis*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D054304:Anti-Mullerian Hormone
keywords: Anti-Müllerian hormone; fecundability; infertility treatment; long-term fertility; ovarian reserve