title: The effect of oral propranolol on intraocular pressure in infants with Sturge-Weber syndrome glaucoma.
abstract: OBJECTIVE
  To report the effect of oral propranolol on intraocular pressure (IOP) in infants newly diagnosed with unilateral Sturge-Weber syndrome (SWS) glaucoma receiving no other treatment.
  
  
  METHODS
  This was a prospective, nonrandomized interventional case series. Four infants presenting with unilateral SWS glaucoma with no prior treatment were treated with oral propranolol at a dose of 2 mg/kg and followed thereafter.
  
  
  RESULTS
  Propranolol had a temporary IOP-lowering effect in 3 of 4 children after 1 week of treatment. This effect diminished thereafter and 3 of 4 children required additional medical or surgical treatment.
  
  
  CONCLUSIONS
  Oral propranolol has a temporary effect on IOP in SWS glaucoma and is not effective as a single treatment in this syndrome, yet can serve to delay surgical treatment for a short period of time. In one case, the glaucoma was well-controlled on this medication.
authors.affiliation: The Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer - Israel.
authors.forename: Tamara
authors.initials: T
authors.lastname: Wygnanski-Jaffe
authors.forename: Abraham
authors.initials: A
authors.lastname: Spierer
authors.forename: Shlomo
authors.initials: S
authors.lastname: Melamed
authors.forename: Itay
authors.initials: I
authors.lastname: Ben-Zion
mesh_terms: D000284:Administration, Oral; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D000959:Antihypertensive Agents / Q000627:therapeutic use; D005260:Female; D005901:Glaucoma / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007223:Infant; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D011433:Propranolol / Q000008:administration & dosage*; D011446:Prospective Studies; D013341:Sturge-Weber Syndrome / Q000150:complications / Q000188:drug therapy*; D014065:Tonometry, Ocular
chemical_list: D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D011433:Propranolol