title: All roads bring to Rome: a different way for predicting success in the therapy of obesity through psychological features.
abstract: OBJECTIVE
  Obesity treatment based on lifestyle modifications is characterized by a high proportion of treatment failures. The study of predictors of success could be useful for a better definition of therapeutic needs in individual patients. Few studies have attempted a comprehensive assessment of psychological factors related with treatment response. Aim of the study is the identification of psychological and psychopathological features associated with a good treatment response in patients referring for obesity.
  
  
  METHODS
  This prospective observational study was conducted on a consecutive series of 270 obese patients and a six-month follow-up was performed. At enrollment, a complete medical history was collected and, psychopathology and psychological features were assessed with: General psychopathology: Symptom Checklist 90-revised, Eating Disorder Examination-Questionnaire, Obesity Related well-being and Treatment, Motivation and Readiness test.
  
  
  RESULTS
  Among the 231 patients evaluated at follow-up, the mean weight loss was 3.2% of initial body weight and 68 patients (29.4%) reached the pre-defined therapeutic target of 5% weight loss. Higher psychopathology was associated with a worse outcome in women only; whereas motivation was higher in patients achieving therapeutic targets among men, but not in women.
  
  
  CONCLUSIONS
  Mean weight loss obtained with lifestyle interventions is confirmed to be rather small and a more accurate selection of patients to be enrolled in lifestyle intervention programs is needed. The present study provides some intriguing information on predictors of weight loss, which could be useful for the identification of patients with a higher chance of succeeding with lifestyle programs for the treatment of obesity.
authors.affiliation: Section of Psychiatry, Careggi University Hospital, Largo Brambilla 3, Florence, Italy, francesco.rotella@unifi.it.
authors.forename: Francesco
authors.initials: F
authors.lastname: Rotella
authors.forename: Lisa
authors.initials: L
authors.lastname: Lazzeretti
authors.forename: Valeria
authors.initials: V
authors.lastname: Barbaro
authors.forename: Giovanni
authors.initials: G
authors.lastname: Castellini
authors.forename: Michela
authors.initials: M
authors.lastname: Bigiarini
authors.forename: Barbara
authors.initials: B
authors.lastname: Cresci
authors.forename: Valdo
authors.initials: V
authors.lastname: Ricca
authors.forename: Carlo Maria
authors.initials: CM
authors.lastname: Rotella
authors.forename: Edoardo
authors.initials: E
authors.lastname: Mannucci
mesh_terms: D000328:Adult; D001521:Behavior Therapy / Q000379:methods / Q000639:trends; D004038:Diet, Reducing / Q000379:methods / Q000523:psychology* / Q000639:trends; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009042:Motivation; D009765:Obesity / Q000175:diagnosis / Q000523:psychology* / Q000628:therapy*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D040242:Risk Reduction Behavior; D011795:Surveys and Questionnaires; D016896:Treatment Outcome