title: Halogenated metabolites isolated from Penicillium citreonigrum.
abstract: Three chromone analogs, 1-3, a chlorinated alkaloid sclerotioramine (4), together with two 11-noreremophilane-type sesquiterpenes with a conjugated enolic OH group and a brominated one, 5 and 6, respectively, were isolated from Penicillium citreonigrum (HQ738282). Compounds 1, 5, and 6 were new. Biological tests revealed that 4 exhibited a significant activity (IC50 7.32 μg/ml), and 6 showed a moderate activity (IC50 16.31 μg/ml) in vitro against HepG2 cell line, and 4 also displayed an activity comparable to that of acarbose against α-glucosidase.
authors.affiliation: Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, Jiangsu Normal University, Xuzhou 221116, P. R. China.
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Yuan
authors.forename: Zhi-Wen
authors.initials: ZW
authors.lastname: Wei
authors.forename: Peng
authors.initials: P
authors.lastname: Dai
authors.forename: Hui
authors.initials: H
authors.lastname: Wu
authors.forename: Yan-Xia
authors.initials: YX
authors.lastname: Zhao
authors.forename: Mei-Mei
authors.initials: MM
authors.lastname: Zhang
authors.forename: Nan
authors.initials: N
authors.lastname: Jiang
authors.forename: Wei-Fa
authors.initials: WF
authors.lastname: Zheng
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018360:Crystallography, X-Ray; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D054879:Halogenation; D056945:Hep G2 Cells; D006801:Humans; D008958:Models, Molecular; D009369:Neoplasms / Q000188:drug therapy; D010407:Penicillium / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D002800:Cholinesterase Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D012717:Sesquiterpenes
keywords: Bioassay; Eremophilane; Fungi; Metabolites; Penicillium citreonigrum; Sclerotioramine; Sesquiterpenes