title: Three acyltetronic acid derivatives: noncanonical cryptic polyketides from Aspergillus niger identified by genome mining.
abstract: Induced production of tetronate derivatives: We activated a dormant PKS-NRPS gene cluster in Aspergillus niger ATCC 1015 by expressing its dedicated transcription activator (caaR). As a result, the transformant expressing caaR produces three acyltetronate derivatives: carlosic acid (1), agglomerin F (2), and carlosic acid methyl ester (3).
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku Tokyo 113-0033 (Japan); College of Pharmaceutical Science, Hebei University, Baoding 071002 (P. R. China).
authors.forename: Xiao-Long
authors.initials: XL
authors.lastname: Yang
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Awakawa
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Wakimoto
authors.forename: Ikuro
authors.initials: I
authors.lastname: Abe
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D001234:Aspergillus niger / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D016681:Genome, Fungal / Q000235:genetics*; D015394:Molecular Structure; D005810:Multigene Family; D048630:Polyketide Synthases / Q000235:genetics / Q000378:metabolism; D061065:Polyketides / Q000737:chemistry / Q000378:metabolism*
chemical_list: D061065:Polyketides; D048630:Polyketide Synthases; D015107:4-Butyrolactone
keywords: biosynthesis; gene expression; genome mining; tetronates; transcription factors