title: Diverse molecular targets for therapeutic strategies in Alzheimer's disease.
abstract: Alzheimer's disease (AD) is the most common form of dementia caused by neurodegenerative process and is tightly related to amyloid β (Aβ) and neurofibrillary tangles. The lack of early diagnostic biomarker and therapeutic remedy hinders the prevention of increasing population of AD patients every year. In spite of accumulated scientific information, numerous clinical trials for candidate drug targets have failed to be preceded into therapeutic development, therefore, AD-related sufferers including patients and caregivers, are desperate to seek the solution. Also, effective AD intervention is desperately needed to reduce AD-related societal threats to public health. In this review, we summarize various drug targets and strategies in recent preclinical studies and clinical trials for AD therapy: Allopathic treatment, immunotherapy, Aβ production/aggregation modulator, tau-targeting therapy and metabolic targeting. Some has already failed in their clinical trials and the others are still in various stages of investigations, both of which give us valuable information for future research in AD therapeutic development.
authors.affiliation: Department of Biochemistry and Biomedical Sciences, Seoul National University, College of Medicine, Seoul, Korea.
authors.forename: Sun-Ho
authors.initials: SH
authors.lastname: Han
authors.affiliation: Department of Biochemistry and Biomedical Sciences, Seoul National University, College of Medicine, Seoul, Korea.
authors.forename: Inhee
authors.initials: I
authors.lastname: Mook-Jung
mesh_terms: D000544:Alzheimer Disease / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors / Q000276:immunology / Q000378:metabolism; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D001921:Brain / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007167:Immunotherapy; D016202:N-Methylaspartate / Q000627:therapeutic use; D016875:tau Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D000911:Antibodies, Monoclonal; D016875:tau Proteins; D016202:N-Methylaspartate
keywords: Aggregation; Alzheimer Disease; Amyloid Beta-Peptides; Glucose Metabolism; Immunotherapy; Tau Protein