title: C-20 Ketone reduction of hydrocortisone by Fusarium solani and Aspergillus ochraceus.
abstract: The biotransformation of hydrocortisone (1) by Fusarium solani and Aspergillus ochraceus was investigated for the first time. After 10 days at 30 °C, just one metabolite was produced by both fungi: 11β, 17α, 20β, 21-tetrahydroxypregn-4-en-3-one (2) established on the basis of spectroscopic data. The reaction was reduction of the 20-carbonyl group. Time course study determined by HPLC showed 60 and 45 % yield for the metabolite by F. solani and A. ochraceus, respectively.
authors.affiliation: Department of Pure Chemistry, Faculty of Chemistry, Shahid Beheshti University G.C, Tehran, Iran, S_gandomkar@sbu.ac.ir.
authors.forename: Somayyeh
authors.initials: S
authors.lastname: Gandomkar
authors.forename: Leila
authors.initials: L
authors.lastname: Hosseinzadeh
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Habibi
mesh_terms: D001235:Aspergillus ochraceus / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D005670:Fusarium / Q000378:metabolism*; D006854:Hydrocortisone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D007659:Ketones / Q000737:chemistry* / Q000378:metabolism*; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D007659:Ketones; C016499:20-hydroxycortisol; D006854:Hydrocortisone