title: Inhibitor screening of lactate dehydrogenase C4 from black-lipped pika in the Western Sichuan Plateau.
abstract: Studies indicated that lactate dehydrogenase C4 (LDH-C4) was a good target protein for development of contraceptive drugs. Virtual screening and in vitro enzyme assay using pika LDH-C4 as target protein revealed NSC61610, NSC215718, and NSC345647 with Ki of 7.8, 27, and 41 μM separately. This study might be helpful for development of pika contraceptive drugs.
authors.affiliation: a School of Laboratory Medicine, Chengdu Medical College , Chengdu , P.R. China.
authors.forename: Qinglian
authors.initials: Q
authors.lastname: Zhang
authors.forename: Qinghua
authors.initials: Q
authors.lastname: He
authors.forename: Fulai
authors.initials: F
authors.lastname: Xue
authors.forename: Jinhu
authors.initials: J
authors.lastname: Ma
mesh_terms: D000818:Animals; D020134:Catalytic Domain; D002681:China; D004353:Drug Evaluation, Preclinical; D004791:Enzyme Inhibitors / Q000378:metabolism / Q000494:pharmacology*; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D007793:Lagomorpha; D062105:Molecular Docking Simulation
chemical_list: D004791:Enzyme Inhibitors; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; C409673:lactate dehydrogenase C4
keywords: Ochotona curzoniae; inhibitor; lactate dehydrogenase C4; virtual screening