title: Oral microbiota distinguishes acute lymphoblastic leukemia pediatric hosts from healthy populations.
abstract: In leukemia, oral manifestations indicate aberrations in oral microbiota. Microbiota structure is determined by both host and environmental factors. In human hosts, how health status shapes the composition of oral microbiota is largely unknown. Taking advantage of advances in high-throughput sequencing, we compared the composition of supragingival plaque microbiota of acute lymphoblastic leukemia (ALL) pediatric patients with healthy controls. The oral microbiota of leukemia patients had lower richness and less diversity compared to healthy controls. Microbial samples clustered into two major groups, one of ALL patients and another of healthy children, with different structure and composition. Abundance changes of certain taxa including the Phylum Firmicutes, the Class Bacilli, the Order Lactobacillales, the Family Aerococcaceae and Carnobacteriaceae, as well as the Genus Abiotrophia and Granulicatella were associated with leukemia status. ALL patients demonstrated a structural imbalance of the oral microbiota, characterized by reduced diversity and abundance alterations, possibly involved in systemic infections, indicating the importance of immune status in shaping the structure of oral microbiota.
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Xue
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
authors.forename: Xuedong
authors.initials: X
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
authors.forename: Meng
authors.initials: M
authors.lastname: You
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Du
authors.affiliation: Department of Pediatric Hematology and Oncology, West China Second University Hospital, Sichuan University, Chengdu, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Yang
authors.forename: Jinzhi
authors.initials: J
authors.lastname: He
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
authors.forename: Jingzhi
authors.initials: J
authors.lastname: He
authors.affiliation: Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zou
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Cheng
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
authors.forename: Mingyun
authors.initials: M
authors.lastname: Li
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Pediatric Hematology and Oncology, West China Second University Hospital, Sichuan University, Chengdu, China.
authors.forename: Yiping
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
authors.forename: Jiyao
authors.initials: J
authors.lastname: Li
authors.affiliation: UCLA School of Dentistry, Los Angeles, California, United States of America.
authors.forename: Wenyuan
authors.initials: W
authors.lastname: Shi
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Xu
mesh_terms: D044822:Biodiversity; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D054892:Metagenome; D064307:Microbiota; D009055:Mouth / Q000382:microbiology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma; D012307:Risk Factors