title: Genome-wide transcriptomic alterations induced by ethanol treatment in human dental pulp stem cells (DPSCs).
abstract: Human dental pulp stem cells (DPSCs) isolated from adult dental pulp are multipotent mesenchymal stem cells that can be directed to differentiate into osteogenic/odontogenic cells and also trans-differentiate into neuronal cells. The utility of DPSC has been explored in odontogenic differentiation for tooth regeneration. Alcohol abuse appears to lead to periodontal disease, tooth decay and mouth sores that are potentially precancerous. Persons who abuse alcohol are at high risk of having seriously deteriorated teeth, gums and compromised oral health in general. It is currently unknown if alcohol exposure has any impact on adult stem cell maintenance, stem cell fate determination and plasticity, and stem cell niche environment. Here we provide detailed experimental methods, analysis and information associated with our data deposited into Gene Expression Omnibus (GEO) under GSE57255. Our data provide transcriptomic changes that are occurring by EtOH treatment of DPSCs at 24-hour and 48-hour time point.
authors.affiliation: Laboratory of Stem Cell and Cancer Epigenetic Research, UCLA School of Dentistry, Los Angeles, CA, USA.
authors.forename: Omar
authors.initials: O
authors.lastname: Khalid
authors.affiliation: Laboratory of Stem Cell and Cancer Epigenetic Research, UCLA School of Dentistry, Los Angeles, CA, USA.
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Kim
authors.affiliation: Department of Biostatistics, UCLA School of Public Health, Los Angeles, CA, USA.
authors.forename: Lewei
authors.initials: L
authors.lastname: Duan
authors.affiliation: Laboratory of Stem Cell and Cancer Epigenetic Research, UCLA School of Dentistry, Los Angeles, CA, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Hoang
authors.affiliation: Department of Biostatistics, UCLA School of Public Health, Los Angeles, CA, USA.
authors.forename: David
authors.initials: D
authors.lastname: Elashoff
authors.affiliation: Laboratory of Stem Cell and Cancer Epigenetic Research, UCLA School of Dentistry, Los Angeles, CA, USA ; Center for Oral and Head/Neck Oncology Research Center, Los Angeles, CA, USA ; Division of Oral Biology and Medicine, UCLA School of Dentistry, Los Angeles, CA, USA ; UCLA's Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA ; UCLA Broad Stem Cell Research Center, Los Angeles, CA, USA.
authors.forename: Yong
authors.initials: Y
authors.lastname: Kim