title: Antibodies to neural and non-neural autoantigens in Japanese patients with CNS demyelinating disorders.
abstract: Anti-aquaporin 4 (AQP4) antibodies (Abs) are essential in neuromyelitis optica spectrum disorders (NMOSD), but the relationship between CNS demyelinating disorders (CNSDD) and other neural Abs remains unclear. Here we screened anti-neural Abs in the sera of 70 Japanese CNSDD patients. While two had only demyelinating events among three anti-N-methyl-d-aspartate receptor (NMDAR) Ab-positive subjects, the other subject who also had anti-AQP4 Abs experienced episodes of anti-NMDAR encephalitis and of NMOSD. Major lesions in the three anti-contactin-associated protein 2 Ab-positive subjects were infratentorial, including one co-carrying anti-AQP4 Abs. Thus, autoantibodies can be clinically silent, but multiple autoantibodies may participate in the pathogenesis.
authors.affiliation: Department of Neurology, Kitano Hospital Medical Research Institute, 2-4-20 Ohgimachi, Kita-ku, Osaka 530-8480, Japan. Electronic address: watanabe-kyu@umin.ac.jp.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Watanabe
authors.affiliation: Department of Neurology, Kitano Hospital Medical Research Institute, 2-4-20 Ohgimachi, Kita-ku, Osaka 530-8480, Japan; Department of Community Network and Collaborative Medicine, Kyoto University Hospital, 54 Kawaharacho Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. Electronic address: takakon78@hotmail.com.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kondo
authors.affiliation: Department of Neurology, Kitano Hospital Medical Research Institute, 2-4-20 Ohgimachi, Kita-ku, Osaka 530-8480, Japan. Electronic address: murakata.kenji@c2.kepco.co.jp.
authors.forename: Kenji
authors.initials: K
authors.lastname: Murakata
authors.affiliation: Department of Neurology, Tenri Hospital, 200 Mishimacho, Tenri, Nara 632-8552, Japan. Electronic address: gohach65@yahoo.co.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kageyama
authors.affiliation: Department of Neurology, Kitano Hospital Medical Research Institute, 2-4-20 Ohgimachi, Kita-ku, Osaka 530-8480, Japan. Electronic address: yokosbt7645@yahoo.co.jp.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Shibata
authors.affiliation: Department of Neurology, Tohoku University School of Medicine, 1-1 Seiryomachi, Aoba-ku, Sendai, Miyagi 980-8574, Japan. Electronic address: t-toshiyuki@mta.biglobe.ne.jp.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Takahashi
authors.affiliation: Department of Neurology, Saitama Medical Center, 1981 Kamoda, Kawagoe, Saitama 350-8550, Japan. Electronic address: drno@saitama-med.ac.jp.
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Nomura
authors.affiliation: Department of Neurology, Kitano Hospital Medical Research Institute, 2-4-20 Ohgimachi, Kita-ku, Osaka 530-8480, Japan. Electronic address: smatsu@kitano-hp.or.jp.
authors.forename: Sadayuki
authors.initials: S
authors.lastname: Matsumoto
mesh_terms: D000328:Adult; D000368:Aged; D051401:Aquaporin 4 / Q000276:immunology*; D044466:Asian People; D001323:Autoantibodies / Q000276:immunology; D001324:Autoantigens / Q000276:immunology*; D004660:Encephalitis / Q000208:ethnology / Q000276:immunology; D005260:Female; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000276:immunology*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000208:ethnology / Q000276:immunology*; D009419:Nerve Tissue Proteins / Q000276:immunology*; D009471:Neuromyelitis Optica / Q000208:ethnology / Q000276:immunology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology
chemical_list: C496030:AQP4 protein, human; D051401:Aquaporin 4; D001323:Autoantibodies; D001324:Autoantigens; C403049:CNTNAP2 protein, human; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D016194:Receptors, N-Methyl-D-Aspartate
keywords: Aquaporin 4; Autoantibodies; CNS demyelinating disorders; Contactin-associated protein 2; Multiple sclerosis; Neuromyelitis optica