title: DNA nanostructure-based imaging probes and drug carriers.
abstract: Self-assembled DNA nanostructures are well-defined nanoscale shapes, with uniform sizes, precise spatial addressability, and excellent biocompatibility. With these features, DNA nanostructures show great potential for biomedical applications; various DNA-based biomedical imaging probes or payload delivery carriers have been developed. In this review, we summarize the recent developments of DNA-based nanostructures as tools for diagnosis and cancer therapy. The biological effects that are brought about by DNA nanostructures are highlighted by in vitro and in vivo imaging, antitumor drug delivery, and immunostimulatory therapy. The challenges and perspectives of DNA nanostructures in the field of nanomedicine are discussed.
authors.affiliation: College of Chemistry & Materials Science, Anhui Normal University, 1 Beijing East Road, 241000, Wuhu, Anhui (China).
authors.forename: Pengfei
authors.initials: P
authors.lastname: Zhan
authors.forename: Qiao
authors.initials: Q
authors.lastname: Jiang
authors.forename: Zhen-Gang
authors.initials: ZG
authors.lastname: Wang
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.forename: Haiyin
authors.initials: H
authors.lastname: Yu
authors.forename: Baoquan
authors.initials: B
authors.lastname: Ding
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D004247:DNA / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D004247:DNA
keywords: DNA nanostructures; DNA origami; cancer therapy; diagnosis; self-assembly