title: Circulating oxidative stress parameters in pre- and post-menopausal healthy women and in women suffering from breast cancer treated or not with neoadjuvant chemotherapy.
abstract: We evaluate here the redox status in pre- and post-menopausal healthy women and in women with breast cancer in order to understand the consequences of the hormonal alterations of menopause for the oxidative stress status, its modifications with breast cancer and the influence of neoadjuvant chemotherapy (NC). To that, serum oxidative stress parameters (total antioxidant capacity, lipid peroxidation and protein oxidation), non-enzyme antioxidant defenses (total glutathione, uric acid and bilirubin) and enzyme antioxidant defenses (superoxide dismutase, catalase and glutathione peroxidase activities) were measured in healthy women and in women with breast cancer divided according to their menopausal status and that received or not NC. Circulating estradiol, progesterone, FSH and LH were also analyzed. We found that menopause itself modifies the redox status of healthy women, being most of these differences also reflected in women with breast cancer. However, several changes occur as a consequence of the disease. Furthermore, NC increases oxidative damage, decreases antioxidant defenses and eliminates the differences found in menopause. We conclude that the normal redox balance is disrupted by breast cancer but is also affected by the hormonal status promoted by menopause. In fact, NC nullifies the differences found between pre- and postmenopausal women in several antioxidant defense systems.
authors.affiliation: Experimental and Clinical Physiopathology Research Group BIO296, Department of Health Sciences, School of Experimental and Health Sciences, University of Jaen, Campus Las Lagunillas, E-23071 Jaen, Spain. Electronic address: mramirez@ujaen.es.
authors.forename: María Jesús
authors.initials: MJ
authors.lastname: Ramírez-Expósito
authors.affiliation: Experimental and Clinical Physiopathology Research Group BIO296, Department of Health Sciences, School of Experimental and Health Sciences, University of Jaen, Campus Las Lagunillas, E-23071 Jaen, Spain.
authors.forename: Estefanía
authors.initials: E
authors.lastname: Sánchez-López
authors.affiliation: Experimental and Clinical Physiopathology Research Group BIO296, Department of Health Sciences, School of Experimental and Health Sciences, University of Jaen, Campus Las Lagunillas, E-23071 Jaen, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Cueto-Ureña
authors.affiliation: Experimental and Clinical Physiopathology Research Group BIO296, Department of Health Sciences, School of Experimental and Health Sciences, University of Jaen, Campus Las Lagunillas, E-23071 Jaen, Spain; Unit of Breast Pathology, University Hospital of Jaén, Jaén, Spain.
authors.forename: Basilio
authors.initials: B
authors.lastname: Dueñas
authors.affiliation: Experimental and Clinical Physiopathology Research Group BIO296, Department of Health Sciences, School of Experimental and Health Sciences, University of Jaen, Campus Las Lagunillas, E-23071 Jaen, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Carrera-González
authors.affiliation: Unit of Breast Pathology, University Hospital of Jaén, Jaén, Spain.
authors.forename: Joaquín
authors.initials: J
authors.lastname: Navarro-Cecilia
authors.affiliation: Experimental and Clinical Physiopathology Research Group BIO296, Department of Health Sciences, School of Experimental and Health Sciences, University of Jaen, Campus Las Lagunillas, E-23071 Jaen, Spain.
authors.forename: María Dolores
authors.initials: MD
authors.lastname: Mayas
authors.affiliation: Unit of Clinical Biochemistry, University Hospital of Jaén, Jaén, Spain.
authors.forename: José M
authors.initials: JM
authors.lastname: Arias de Saavedra
authors.affiliation: Experimental and Clinical Physiopathology Research Group BIO296, Department of Health Sciences, School of Experimental and Health Sciences, University of Jaen, Campus Las Lagunillas, E-23071 Jaen, Spain; Unit of Clinical Biochemistry, University Hospital of Jaén, Jaén, Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: Sánchez-Agesta
authors.affiliation: Experimental and Clinical Physiopathology Research Group BIO296, Department of Health Sciences, School of Experimental and Health Sciences, University of Jaen, Campus Las Lagunillas, E-23071 Jaen, Spain.
authors.forename: José M
authors.initials: JM
authors.lastname: Martínez-Martos
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001943:Breast Neoplasms / Q000097:blood* / Q000188:drug therapy*; D016022:Case-Control Studies; D017024:Chemotherapy, Adjuvant; D004798:Enzymes / Q000097:blood; D005260:Female; D006728:Hormones / Q000097:blood*; D006801:Humans; D015227:Lipid Peroxidation; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects*; D017698:Postmenopause / Q000097:blood*; D017697:Premenopause / Q000097:blood*; D050050:Protein Carbonylation
chemical_list: D015415:Biomarkers; D004798:Enzymes; D006728:Hormones
keywords: Breast cancer; Carbonyls; Catalase; Direct bilirubin; Estradiol; GSH; Glutathione peroxidase; LH/FSH ratio; Menopause; Neoadjuvant chemotherapy; Oxidative stress; Progesterone; Superoxide dismutase; TBARS; Uric acid