title: [Antibody therapy for hematopoietic malignancies and cell surface antigen testing].
abstract: In recent years, the diagnostic and therapeutic approaches for malignant neoplasms have significantly improved. With the development of molecular targeted diagnosis or therapeutic drugs, marked progress has been achieved in predicting the therapeutic effect and the prognosis. In this context, progress in molecular biology and immunological cellular antigen-searching techniques has played an important role. Hematopoietic malignancies are not an exception, and also depend on these analytical techniques. For therapeutic approaches using these techniques, it is necessary to accurately determine the responsible gene or target cellular surface antigen. It is now becoming possible to determine these genes or cancer cell specific antigens with high-level accuracy. It is evident that accurate laboratory test results of features of cancer cells are essential for the implementation of appropriate therapeutic approaches. In this chapter, an overview of antibody therapy for hematopoietic malignancies and laboratory testing will be presented.
authors.forename: Katsumi
authors.initials: K
authors.lastname: Higashi
mesh_terms: D000818:Animals; D000906:Antibodies / Q000627:therapeutic use*; D000954:Antigens, Surface / Q000276:immunology*; D005434:Flow Cytometry; D019337:Hematologic Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D058990:Molecular Targeted Therapy; D011379:Prognosis
chemical_list: D000906:Antibodies; D000954:Antigens, Surface