title: Circadian control of tissue homeostasis and adult stem cells.
abstract: The circadian timekeeping mechanism adapts physiology to the 24-hour light/dark cycle. However, how the outputs of the circadian clock in different peripheral tissues communicate and synchronize each other is still not fully understood. The circadian clock has been implicated in the regulation of numerous processes, including metabolism, the cell cycle, cell differentiation, immune responses, redox homeostasis, and tissue repair. Accordingly, perturbation of the machinery that generates circadian rhythms is associated with metabolic disorders, premature ageing, and various diseases including cancer. Importantly, it is now possible to target circadian rhythms through systemic or local delivery of time cues or compounds. Here, we summarize recent findings in peripheral tissues that link the circadian clock machinery to tissue-specific functions and diseases.
authors.affiliation: Center for Integrative Genomics, University of Lausanne, CH-1015 Lausanne, Switzerland.
authors.forename: Peggy
authors.initials: P
authors.lastname: Janich
authors.affiliation: MRC Career Development Award Fellow, Faculty of Life Sciences, University of Manchester, United Kingdom.
authors.forename: Qing-Jun
authors.initials: QJ
authors.lastname: Meng
authors.affiliation: Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain; Institute for Research in Biomedicine (IRB Barcelona), Barcelona, Spain. Electronic address: salvador.aznar-benitah@irbbarcelona.org.
authors.forename: Salvador Aznar
authors.initials: SA
authors.lastname: Benitah
mesh_terms: D053687:Adult Stem Cells / Q000166:cytology / Q000502:physiology*; D000818:Animals; D002453:Cell Cycle; D002454:Cell Differentiation; D057906:Circadian Clocks; D002940:Circadian Rhythm; D006706:Homeostasis; D006801:Humans; D009928:Organ Specificity; D013493:Suprachiasmatic Nucleus / Q000502:physiology