title: Topical herbal application in the management of atopic dermatitis: a review of animal studies.
abstract: Herbs are widely used in the treatment of atopic dermatitis (AD) in Eastern Asian countries, and certain herbs regarded have anti-inflammatory properties that can help with AD. With the goal of developing a topical herbal agent for AD, we conducted a systematic review of in vivo studies of AD-like skin models for screening potential herbs. Searches were conducted from PubMed and EMBASE. After all, 22 studies were included for this review. We judged most of the domains of all studies to be at unclear risk of bias. Among 22 included studies, 21 herbs have been reported to reduce AD-like skin lesions in mouse models by suppressing Th2 cell response. Our findings may offer potential herbs for the topical application treatment of AD.
authors.affiliation: Department of Dermatology of Korean Medicine, College of Korean Medicine, Graduate School of Kyung Hee University, Seoul 130-701, Republic of Korea ; Department of Dermatology of Korean Medicine, Kyung Hee University Hospital at Gangdong, No. 149 Sangil-dong, Gangdong-gu, Seoul 134-090, Republic of Korea.
authors.forename: Younghee
authors.identifier: 0000-0001-8489-8476
authors.initials: Y
authors.lastname: Yun
authors.affiliation: Department of Ophthalmology & Otorhinolaryngology & Dermatology of Korean Medicine, College of Korean Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea.
authors.forename: Kyuseok
authors.initials: K
authors.lastname: Kim
authors.affiliation: Department of Dermatology of Korean Medicine, Kyung Hee University Hospital at Gangdong, No. 149 Sangil-dong, Gangdong-gu, Seoul 134-090, Republic of Korea ; Department of Ophthalmology & Otorhinolaryngology & Dermatology of Korean Medicine, College of Korean Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea.
authors.forename: Inhwa
authors.initials: I
authors.lastname: Choi
authors.affiliation: Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea.
authors.forename: Seong-Gyu
authors.initials: SG
authors.lastname: Ko
mesh_terms: D000287:Administration, Topical; D000818:Animals; D003876:Dermatitis, Atopic / Q000188:drug therapy*; D010936:Plant Extracts / Q000008:administration & dosage* / Q000627:therapeutic use*; D012867:Skin / Q000187:drug effects / Q000473:pathology
chemical_list: D010936:Plant Extracts