title: Viral hepatitis and liver transplantation: pathogenesis, prevention and therapy of recurrent disease.
abstract: Cirrhosis secondary to hepatitis C virus infection is the leading cause of liver transplantation in most countries. Hepatitis C has an accelerated course after transplantation, and for this reason graft and patient survival are decreased in comparison with other indications of liver transplantation. The development of direct-acting antivirals has been a major step in the management of hepatitis C and in a few years from now the infection will be eradicated with the combination of oral drugs with a good safety profile. This will likely allow prevention of hepatitis C recurrence in most cases. Meanwhile, management of hepatitis C virus infection still relies on the combination of interferon, ribavirin and the first-generation protease inhibitors telaprevir and boceprevir.
authors.affiliation: Liver Unit, Hospital Clinic, IDIBAPS and CIBEREHD, Barcelona, Spain.
authors.forename: Martina
authors.initials: M
authors.lastname: Gambato
authors.forename: Sabela
authors.initials: S
authors.lastname: Lens
authors.forename: Carlos
authors.initials: C
authors.lastname: Fernández-Carrillo
authors.forename: Ignacio
authors.initials: I
authors.lastname: Alfaro
authors.forename: Xavier
authors.initials: X
authors.lastname: Forns
mesh_terms: D006525:Hepatitis, Viral, Human / Q000517:prevention & control / Q000628:therapy* / Q000821:virology*; D006801:Humans; D016031:Liver Transplantation; D012008:Recurrence