title: [N-stearoylethanolamine effect on the level of 11-hydroxycorticosteroids, cytokines IL-1, IL-6 and TNFalpha in rats with nonspecific inflammation caused by thermal burn of skin].
abstract: The mechanisms of anti-inflammatory action of saturated N-acylethanolamine--N-stearoylethanolamine (NSE) were investigated on the rat model of nonspecific inflammation (thermal burns of the skin). The results showed that the NSE application in a form of aqueous suspension (10 mg/ml) on the damaged skin area during 12 days significantly accelerated the healing process of burned wounds. NSE also prevented the increase of 11-hydroxycorticosteroids content in the blood of rats with burns. There was also found a significant decrease of cytokines (IL-1beta, IL-6 and TNFalpha) levels under the NSE action. This way may be one of the mechanisms of NSE anti-inflammatory action.
authors.forename: O D
authors.initials: OD
authors.lastname: Zhukov
authors.forename: A H
authors.initials: AH
authors.lastname: Berdyshev
authors.forename: H V
authors.initials: HV
authors.lastname: Kosiakova
authors.forename: V M
authors.initials: VM
authors.lastname: Klimashevs'kyĭ
authors.forename: T M
authors.initials: TM
authors.lastname: Horid'ko
authors.forename: O F
authors.initials: OF
authors.lastname: Mehed'
authors.forename: N M
authors.initials: NM
authors.lastname: Hula
mesh_terms: D015062:11-Hydroxycorticosteroids / Q000097:blood*; D000279:Administration, Cutaneous; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002056:Burns / Q000097:blood / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D004983:Ethanolamines / Q000494:pharmacology*; D006358:Hot Temperature; D007249:Inflammation / Q000097:blood / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D053583:Interleukin-1beta / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects* / Q000276:immunology / Q000293:injuries; D013229:Stearic Acids / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
chemical_list: D015062:11-Hydroxycorticosteroids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004983:Ethanolamines; D053583:Interleukin-1beta; D015850:Interleukin-6; C022203:N-acylethanolamines; C408368:N-stearoylethanolamine; D013229:Stearic Acids; D014409:Tumor Necrosis Factor-alpha