title: Monocytes as regulators of inflammation and HIV-related comorbidities during cART.
abstract: Combined antiretroviral therapy (cART) extends the lifespan and the quality of life for HIV-infected persons but does not completely eliminate chronic immune activation and inflammation. The low level of chronic immune activation persisting during cART-treated HIV infection is associated with the development of diseases which usually occur in the elderly. Although T-cell activation has been extensively examined in the context of cART-treated HIV infection, monocyte activation is only beginning to be recognized as an important source of inflammation in this context. Here we examine markers and sources of monocyte activation during cART-treated HIV infection and discuss the role of monocytes during cardiovascular disease, HIV-associated neurocognitive disorder, and innate immune aging.
authors.affiliation: Department of Microbiology, The University of the West Indies, Kingston, Jamaica.
authors.forename: Joshua J
authors.initials: JJ
authors.lastname: Anzinger
authors.affiliation: Department of Microbiology, The University of the West Indies, Kingston, Jamaica.
authors.forename: Tiffany R
authors.initials: TR
authors.lastname: Butterfield
authors.affiliation: Centre for Biomedical Research, Macfarlane Burnet Institute for Medical Research and Public Health, GPO Box 2284, Melbourne, VIC 3001, Australia ; School of Applied Sciences, RMIT University, Melbourne, VIC 3000, Australia.
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Angelovich
authors.affiliation: Centre for Biomedical Research, Macfarlane Burnet Institute for Medical Research and Public Health, GPO Box 2284, Melbourne, VIC 3001, Australia ; Department of Medicine, Monash University, Melbourne, VIC 3800, Australia ; Department of Infectious Diseases, Monash University, Melbourne, VIC 3800, Australia.
authors.forename: Suzanne M
authors.initials: SM
authors.lastname: Crowe
authors.affiliation: Centre for Biomedical Research, Macfarlane Burnet Institute for Medical Research and Public Health, GPO Box 2284, Melbourne, VIC 3001, Australia.
authors.forename: Clovis S
authors.initials: CS
authors.lastname: Palmer
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D015897:Comorbidity; D016207:Cytokines / Q000378:metabolism; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D056747:Immunomodulation; D007249:Inflammation / Q000150:complications / Q000276:immunology*; D018836:Inflammation Mediators / Q000378:metabolism; D009000:Monocytes / Q000276:immunology* / Q000378:metabolism
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators