title: Proteomics focusing on immune markers in psoriatic arthritis.
abstract: The immune-pathogenesis of psoriatic arthritis represents a subject of intense research, as a still unknown factor can trigger the chronic inflammation that, upon a defective immune terrain, generates this auto-immune/auto-inflammatory condition. The pathogenesis complexity of psoriatic arthritis resides in the psoriatic synovitis milieu, where intricate immune relations are emerging during disease development. Innate immune response generates inflammatory cytokines driving effectors functions for immune and non-immune cells that sustain the chronical character of the synovitis. Herein, we review the updated information regarding biomarkers/immune markers that sustain the heterogeneity and complexity of psoriatic arthritis pathogenesis, this complexity leading to multifaceted methodological approaches for disease investigation. New immune proteomic or genomic biomarkers can enlarge and identify new therapeutic targets.
authors.affiliation: Dermatology Research Laboratory, "Carol Davila" University of Medicine & Pharmacy, 22-24 Gr. Manolescu, 0111234, Sector 1, Bucharest, Romania.|"Victor Babes" National Institute of Pathology,99-101 Splaiul Independentei, 050096, Bucharest, Romania.
authors.forename: Constantin
authors.initials: C
authors.lastname: Caruntu
authors.affiliation: Dermatology Research Laboratory, "Carol Davila" University of Medicine & Pharmacy, 22-24 Gr. Manolescu, 0111234, Sector 1, Bucharest, Romania.
authors.forename: Daniel
authors.initials: D
authors.lastname: Boda
authors.affiliation: "Victor Babes" National Institute of Pathology,99-101 Splaiul Independentei, 050096, Bucharest, Romania.
authors.forename: Georgiana
authors.initials: G
authors.lastname: Dumitrascu
authors.affiliation: "Victor Babes" National Institute of Pathology,99-101 Splaiul Independentei, 050096, Bucharest, Romania.
authors.forename: Carolina
authors.initials: C
authors.lastname: Constantin
authors.affiliation: "Victor Babes" National Institute of Pathology,99-101 Splaiul Independentei, 050096, Bucharest, Romania.
authors.forename: Monica
authors.initials: M
authors.lastname: Neagu
mesh_terms: D015535:Arthritis, Psoriatic / Q000276:immunology* / Q000473:pathology; D015415:Biomarkers; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D040901:Proteomics / Q000379:methods*
chemical_list: D015415:Biomarkers; D016207:Cytokines
keywords: diagnosis; immune markers; immune therapy; proteomics; psoriatic arthritis