title: Circulating microRNAs as biomarkers for inflammatory diseases.
abstract: MicroRNAs (miRNAs), a class of small, non-coding RNA molecules with gene regulatory functions, have emerged to play a critical role in the pathogenesis of a variety of diseases. Current technological advances allow accurate, high throughput profiling of miRNA abundance in different tissues. More recently, extracellular, circulating miRNAs have begun to be demonstrated as highly stable, blood-based biomarkers for diseases. Understanding the interactions between circulating miRNAs and clinical phenotypes can enhance our knowledge of complex diseases and traits. On the other hand, given the advantages of utilizing blood-based biomarkers (e.g., convenience in collecting samples), circulating miRNAs as biomarkers may improve both disease diagnosis and management. Particularly, we reviewed recent progress in identifying circulating miRNAs as biomarkers for several common inflammatory diseases including asthma, inflammatory bowel disease, and rheumatoid arthritis. Current studies showed a promising future of using circulating miRNAs in the care of inflammatory diseases.
authors.affiliation: Laboratory of Disease Genomics and Individualized Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100029, China.
authors.forename: Shuangli
authors.initials: S
authors.lastname: Mi
authors.affiliation: Laboratory of Disease Genomics and Individualized Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100029, China ; Graduate university of Chinese Academy of Sciences, Beijing, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Pediatrics, University of Illinois at Chicago, Chicago, IL 60612, USA ; Institute of Human Genetics, University of Illinois at Chicago, Chicago, IL 60612, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Medicine, The University of Chicago, Chicago, IL, 60637, USA.
authors.forename: R Stephanie
authors.initials: RS
authors.lastname: Huang
mesh_terms: D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D001249:Asthma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D015415:Biomarkers / Q000097:blood*; D005786:Gene Expression Regulation; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D035683:MicroRNAs / Q000097:blood*
chemical_list: D015415:Biomarkers; D035683:MicroRNAs
keywords: Asthma; biomarkers; circulating markers; inflammatory bowl disease; microRNA; rheumatoid arthritis