title: Hippo-YAP signaling pathway: A new paradigm for cancer therapy.
abstract: In the past decades, the Hippo signaling pathway has been delineated and shown to play multiple roles in the control of organ size in both Drosophila and mammals. In mammals, the Hippo pathway is a kinase cascade leading from Mst1/2 to YAP and its paralog TAZ. Several studies have demonstrated that YAP/TAZ is a candidate oncogene and that other members of the Hippo pathway are tumor suppressive genes. The dysregulation of the Hippo pathway has been observed in a variety of cancers. This review chronicles the recent progress in elucidating the function of Hippo signaling in tumorigenesis and provide a rich source of potential targets for cancer therapy.
authors.affiliation: Department of GI Surgery, Shanghai Tenth People's Hospital Affiliated with Tongji University, Shanghai, People's Republic of China.
authors.forename: Yanlei
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of GI Surgery, Shanghai Tenth People's Hospital Affiliated with Tongji University, Shanghai, People's Republic of China.
authors.forename: Yongzhi
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of GI Surgery, Shanghai Tenth People's Hospital Affiliated with Tongji University, Shanghai, People's Republic of China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Pathology, Shanghai Tenth People's Hospital Affiliated with Tongji University, Shanghai, People's Republic of China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Wei
authors.affiliation: Department of GI Surgery, Shanghai Tenth People's Hospital Affiliated with Tongji University, Shanghai, People's Republic of China.
authors.forename: Huanlong
authors.initials: H
authors.lastname: Qin
mesh_terms: D000217:Acyltransferases; D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D000818:Animals; D000090683:Hippo Signaling Pathway; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology*; D009929:Organ Size; D010750:Phosphoproteins / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D014157:Transcription Factors / Q000378:metabolism; D000091102:YAP-Signaling Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D010750:Phosphoproteins; D014157:Transcription Factors; D000091102:YAP-Signaling Proteins; C088374:YAP1 protein, human; D000217:Acyltransferases; C108675:TAFAZZIN protein, human; D017346:Protein Serine-Threonine Kinases
keywords: cancer; hippo; therapy; yap