title: Laparoscopic kidney transplant by extra peritoneal approach: the safe transition from laboratory to the clinic.
abstract: The aim of this study is to develop a novel laparoscopic surgery by extra-peritoneal approach for kidney transplant and pave the way of safe transition from laboratory to the clinic. The study was established to explore the feasibility and safety of human laparoscopic kidney transplant. The experiment was first conducted on the deceased animals, then live animals and human cavader before human kidney transplant was approved. The study patient was a 49-year-old male who received the kidney for laparoscopic kidney transplant by extra-peritoneal approach. The control patient received the contralateral kidney for open kidney transplant. The estimated blood loss was minimal during surgery. Both kidneys experienced delayed graft function but the kidneys started function on Day 6 postoperation. The analgesia consumption was significantly less in the study patient. There is no surgical complication during 6-month follow-up. This study has developed a new technique for laparoscopic kidney transplant by extra-peritoneal approach. It has retained the advantages of open kidney transplant, which allows the graft located in the extra-peritoneal space without violating peritoneum. This study has also paved the way of safe transition for a novel laparoscopic surgery from laboratory to the clinic.
authors.forename: B
authors.initials: B
authors.lastname: He
authors.forename: L
authors.initials: L
authors.lastname: Mou
authors.forename: K
authors.initials: K
authors.lastname: Sharpe
authors.forename: R
authors.initials: R
authors.lastname: Swaminathan
authors.forename: J
authors.initials: J
authors.lastname: Hamdorf
authors.forename: L
authors.initials: L
authors.lastname: Delriviere
mesh_terms: D000328:Adult; D000368:Aged; D000714:Anastomosis, Surgical; D000818:Animals; D002102:Cadaver; D006801:Humans; D007668:Kidney / Q000601:surgery*; D016030:Kidney Transplantation / Q000379:methods*; D010535:Laparoscopy / Q000379:methods; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy / Q000379:methods; D012077:Renal Artery / Q000473:pathology; D051437:Renal Insufficiency / Q000601:surgery*; D012082:Renal Veins / Q000473:pathology; D013552:Swine; D013997:Time Factors; D016896:Treatment Outcome; D014513:Ureter / Q000601:surgery; D001743:Urinary Bladder / Q000601:surgery