title: A new twist on transcriptional bursting.
abstract: Transcriptional bursting has been observed across species and is one of the primary causes of variable gene expression in cells and tissue. In this issue, Chong et al. describe how DNA topology results in transcriptional bursting in E. coli.
authors.affiliation: Center for Cancer Research, National Cancer Institute, Bethesda, MD 20814, USA.
authors.forename: David
authors.initials: D
authors.lastname: Levens
authors.affiliation: Center for Cancer Research, National Cancer Institute, Bethesda, MD 20814, USA. Electronic address: dan.larson@nih.gov.
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Larson
mesh_terms: D004926:Escherichia coli / Q000235:genetics*; D014158:Transcription, Genetic