title: Enantiospecific total synthesis of macrolactone Sch 725674.
abstract: The enantiospecific total synthesis of 14-membered macrolactone Sch 725674 was accomplished from tartaric acid. Key reactions in the synthesis include the Ley's dithiaketalization of an alkynone derived from the bis-Weinreb amide of tartaric acid, Boord olefination, and ring-closing metathesis of an acrylate ester.
authors.affiliation: Department of Organic Chemistry, Indian Institute of Science , Bangalore 560 012, India.
authors.forename: Amit K
authors.initials: AK
authors.lastname: Bali
authors.forename: Sunil K
authors.initials: SK
authors.lastname: Sunnam
authors.forename: Kavirayani R
authors.initials: KR
authors.lastname: Prasad
mesh_terms: D000179:Acrylates / Q000737:chemistry; D000577:Amides / Q000737:chemistry; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D013644:Tartrates / Q000737:chemistry*
chemical_list: D000179:Acrylates; D000577:Amides; D018942:Macrolides; C506328:Sch 725674; D013644:Tartrates; C036658:acrylic acid; C029768:tartaric acid