title: Innate immune cells express IL-17A/F in acute generalized exanthematous pustulosis and generalized pustular psoriasis.
abstract: Acute generalized exanthematous pustulosis (AGEP) and generalized pustular psoriasis (GPP) are rare pustular skin disorders with systemic involvement. IL-17A/F is a proinflammatory cytokine involved in various neutrophilic inflammatory disorders. Here we show that IL-17A/F is highly expressed by innate immune cells such as neutrophils and mast cells in both AGEP and GPP.
authors.affiliation: Department of Dermatology, Inselspital Bern University Hospital, 3010, Bern, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Kakeda
authors.forename: Christoph
authors.initials: C
authors.lastname: Schlapbach
authors.forename: G
authors.initials: G
authors.lastname: Danelon
authors.forename: M M
authors.initials: MM
authors.lastname: Tang
authors.forename: V
authors.initials: V
authors.lastname: Cecchinato
authors.forename: N
authors.initials: N
authors.lastname: Yawalkar
authors.forename: M
authors.initials: M
authors.lastname: Uguccioni
mesh_terms: D056150:Acute Generalized Exanthematous Pustulosis / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007113:Immunity, Innate; D018836:Inflammation Mediators / Q000276:immunology / Q000378:metabolism*; D020381:Interleukin-17 / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D008297:Male; D008407:Mast Cells / Q000276:immunology / Q000378:metabolism*; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology / Q000378:metabolism*; D011565:Psoriasis / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D015398:Signal Transduction; D012867:Skin / Q000276:immunology / Q000378:metabolism*; D055815:Young Adult
chemical_list: C508717:IL17A protein, human; C440021:IL17F protein, human; D018836:Inflammation Mediators; D020381:Interleukin-17; D012333:RNA, Messenger