title: Will studies in individuals with systemic lupus erythematosus be the key to future HIV vaccine design?
abstract: The induction of HIV-1 broadly neutralizing antibodies (bnAbs) remains the primary goal of a preventive HIV-1 vaccine but no HIV-1 vaccine candidate has succeeded in inducing bnAbs. All the bnAbs isolated from chronically HIV-1 infected subjects display one or more traits associated with control by host tolerance and immunoregulatory mechanisms, including reactivity against self antigens. Recent studies on a HIV-1 patient with concurrent systemic lupus erythematosus have informed on how similar bnAbs are to typical autoantibodies controlled by immune tolerance mechanisms. Future studies aimed at elucidating the intersection between autoantibodies generated in the context of systemic lupus erythematosus and the development of HIV-1 bnAbs will further our knowledge of specific roadblocks that hamper the production of bnAbs and, ultimately, inform us on how to implement vaccine strategies to circumvent them.
authors.affiliation: Duke Human Vaccine Institute, Duke University Medical Center, MSRB II - Room 4013, PO Box 103020, 2 Genome Court, Durham, NC 27710, USA.
authors.forename: Mattia
authors.initials: M
authors.lastname: Bonsignori
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology* / Q000302:isolation & purification*; D057134:Antibodies, Neutralizing / Q000097:blood; D001323:Autoantibodies / Q000097:blood*; D015483:HIV Antibodies / Q000097:blood*; D015658:HIV Infections / Q000517:prevention & control*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*
chemical_list: D016915:AIDS Vaccines; D057134:Antibodies, Neutralizing; D001323:Autoantibodies; D015483:HIV Antibodies
keywords: HIV-1 broadly neutralizing antibodies; HIV-1 vaccine; HIV-1 vaccine design; SLE; autoreactive antibody; autoreactivity; immune tolerance; systemic lupus erythematosus