title: α-Glucosidase and lipoxygenase inhibitory derivatives of cryptosporioptide from the endophytic fungus Cryptosporiopsis sp.
abstract: Two new cryptosporioptide-derived polyketides cryptosporioptides A (2) and B (3) were isolated from the extract of endophytic fungus Cryptosporiopsis sp. associated with the shrub, Viburnum tinus. The structures of the isolates were determined through spectral analysis including 1D NMR ((1)H, (13)C) and 2D NMR (HSQC, HMBC, COSY) techniques, HR-FAB-MS and by comparison with the reported data of cryptosporioptide (1). The relative stereochemistry was assigned with the help of NOESY analysis, the molecular model, and comparison of the optical rotation values with the reference compound 1.
authors.affiliation: a Department of Chemistry , Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur , Bahawalpur 63100 , Pakistan.
authors.forename: Muhammad Imran
authors.initials: MI
authors.lastname: Tousif
authors.forename: Natasha
authors.initials: N
authors.lastname: Shazmeen
authors.forename: Naheed
authors.initials: N
authors.lastname: Riaz
authors.forename: Nusrat
authors.initials: N
authors.lastname: Shafiq
authors.forename: Tasneem
authors.initials: T
authors.lastname: Khatoon
authors.forename: Barbara
authors.initials: B
authors.lastname: Schulz
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ashraf
authors.forename: Ayesha
authors.initials: A
authors.lastname: Shaukat
authors.forename: Hidayat
authors.initials: H
authors.lastname: Hussain
authors.forename: Abdul
authors.initials: A
authors.lastname: Jabbar
authors.forename: Muhammad
authors.initials: M
authors.lastname: Saleem
mesh_terms: D000465:Algorithms; D001203:Ascomycota / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D008084:Lipoxygenase / Q000187:drug effects*; D008958:Models, Molecular; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D027925:Viburnum / Q000382:microbiology; D000520:alpha-Glucosidases / Q000187:drug effects*
chemical_list: D061065:Polyketides; C586992:cryptosporioptide; C000594269:cryptosporioptide A; C000594270:cryptosporioptide B; D008084:Lipoxygenase; D000520:alpha-Glucosidases
keywords: Cryptosporiopsis fungus; cryptosporioptide derivatives; enzyme inhibition; isolation; structure elucidation