title: Attenuation by a Vigna nakashimae extract of nonalcoholic fatty liver disease in high-fat diet-fed mice.
abstract: A Vigna nakashimae (VN) extract has been shown to have antidiabetic and anti-obesity effects. However, the mechanism underlying the effect of a VN extract on hepatic inflammation and endoplasmic reticulum (ER) stress remains unclear. In the present study, we investigated how a VN extract protects against the development of non-alcoholic fatty liver disease (NAFLD). A VN extract for 12 weeks reduced the body weight, serum metabolic parameters, cytokines, and hepatic steatosis in high-fat diet (HFD)-fed mice. A VN extract decreased HFD-induced hepatic acetyl CoA carboxylase and glucose transporter 4 expressions. In addition to the levels of high-mobility group box 1 and receptor for advanced glycation, the hepatic expression of ATF4 and caspase-3 was also reduced by a VN extract. Thus, these data indicate that a chronic VN extract prevented NAFLD through multiple mechanisms, including inflammation, ER stress, and apoptosis in the liver.
authors.affiliation: a Department of Pediatrics , Oregon Health and Science University , Portland , OR , USA.
authors.forename: Byeong Tak
authors.initials: BT
authors.lastname: Jeon
authors.forename: Rok Won
authors.initials: RW
authors.lastname: Heo
authors.forename: Hyun Joo
authors.initials: HJ
authors.lastname: Shin
authors.forename: Chin-Ok
authors.initials: CO
authors.lastname: Yi
authors.forename: Yu Hee
authors.initials: YH
authors.lastname: Lee
authors.forename: Han-Nah
authors.initials: HN
authors.lastname: Joung
authors.forename: Jung Hwa
authors.initials: JH
authors.lastname: Jung
authors.forename: Jaehoon
authors.initials: J
authors.lastname: Jung
authors.forename: Soo Kyoung
authors.initials: SK
authors.lastname: Kim
authors.forename: Jong Ryeal
authors.initials: JR
authors.lastname: Hahm
authors.forename: Byong Won
authors.initials: BW
authors.lastname: Lee
authors.forename: Jong Min
authors.initials: JM
authors.lastname: Ko
authors.forename: In Youl
authors.initials: IY
authors.lastname: Baek
authors.forename: Sang Soo
authors.initials: SS
authors.lastname: Kang
authors.forename: Gu Seob
authors.initials: GS
authors.lastname: Roh
mesh_terms: D000103:Acetyl-CoA Carboxylase / Q000096:biosynthesis; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D059305:Diet, High-Fat; D007887:Fabaceae / Q000737:chemistry*; D005786:Gene Expression Regulation / Q000187:drug effects; D051275:Glucose Transporter Type 4 / Q000096:biosynthesis; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D050356:Lipid Metabolism / Q000187:drug effects; D051379:Mice; D065626:Non-alcoholic Fatty Liver Disease / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D051275:Glucose Transporter Type 4; D010936:Plant Extracts; D000103:Acetyl-CoA Carboxylase
keywords: Vigna nakashimae; endoplasmic reticulum stress; inflammation; nonalcoholic fatty liver disease