title: Seven new sesquiterpenoids from the fruits of Schisandra sphenanthera.
abstract: Fractionation of the EtOH extract from the fruits of Schisandra sphenanthera resulted in the isolation of seven new sesquiterpenoids, 1-7, in addition to the known metabolites 8-23. Among them, schiscupatetralin A (1) possesses an unprecedented structure with a CC bond between cuparenol and tetralin. The isolated new compounds were evaluated for their anti-HSV-1 and anti-inflammatory activities. The results revealed that compound 4 exhibited anti-HSV-1 activity, while compound 6 showed a significant anti-inflammatory activity.
authors.affiliation: School of Pharmacy, College of Medicine, National Taiwan University, Jen-Ai Rd. Sec. 1, Taipei 100, Taiwan (phone: +886-2-23123456, ext. 62226; fax: +886-2-23919098).
authors.forename: Yao-Ching
authors.initials: YC
authors.lastname: Tsai
authors.forename: Yuan-Bin
authors.initials: YB
authors.lastname: Cheng
authors.forename: I-Wen
authors.initials: IW
authors.lastname: Lo
authors.forename: Ho-Hsi
authors.initials: HH
authors.lastname: Cheng
authors.forename: Ching-Jie
authors.initials: CJ
authors.lastname: Lin
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.forename: Yuh-Chi
authors.initials: YC
authors.lastname: Kuo
authors.forename: Shorong-Shii
authors.initials: SS
authors.lastname: Liou
authors.forename: Yi-Zsau
authors.initials: YZ
authors.lastname: Huang
authors.forename: Yao-Haur
authors.initials: YH
authors.lastname: Kuo
authors.forename: Ya-Ching
authors.initials: YC
authors.lastname: Shen
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry*; D006561:Herpes Simplex / Q000188:drug therapy; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D006801:Humans; D008958:Models, Molecular; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D032141:Schisandra / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D000998:Antiviral Agents; D012717:Sesquiterpenes
keywords: Anti-HSV-1 activity; Anti-inflammatory activity; Schisandra sphenanthera; Sesquiterpenoids