title: The prognostic implications from molecular testing of thyroid cancer.
abstract: Thyroid cancer is the most common endocrine malignancy and its incidence has increased over the past few decades. Most patients with thyroid cancer have an excellent prognosis, but there is a 15% recurrence rate within 10 years after initial treatment and mortality is possible. To date, there are no prospective, well-defined data supporting the use of molecular markers alone to decide the extent of treatment of patients with thyroid cancer or to predict the individual prognosis of these patients. Molecular markers are promising in the development of new targeted therapies particularly for radioiodine-refractory and unresectable thyroid cancers.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Outpatient Center, The Johns Hopkins University School of Medicine, 601 North Caroline Street, 6th Floor, Baltimore, MD 21287, USA.
authors.forename: Ozan B
authors.initials: OB
authors.lastname: Ozgursoy
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Outpatient Center, The Johns Hopkins University School of Medicine, 601 North Caroline Street, 6th Floor, Baltimore, MD 21287, USA.
authors.forename: David W
authors.initials: DW
authors.lastname: Eisele
authors.affiliation: Division of Head and Neck Endocrine Surgery, Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Outpatient Center, The Johns Hopkins University School of Medicine, 601 North Caroline Street, 6th Floor, Baltimore, MD 21287, USA. Electronic address: rtufano1@jhmi.edu.
authors.forename: Ralph P
authors.initials: RP
authors.lastname: Tufano
mesh_terms: D002277:Carcinoma / Q000235:genetics; D002291:Carcinoma, Papillary; D006801:Humans; D008207:Lymphatic Metastasis; D011379:Prognosis; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics; D051096:Proto-Oncogene Proteins c-ret / Q000235:genetics; D018570:Risk Assessment; D015398:Signal Transduction / Q000235:genetics; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy
chemical_list: D051096:Proto-Oncogene Proteins c-ret; C099282:RET protein, human; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf
keywords: BRAF; Molecular genetics; PAX8-PPAR; Prognosis; RAS; RET/PTC; Targeted therapy; Thyroid cancer