title: Acute adriamycin-induced cardiotoxicity is exacerbated by angiotension II.
abstract: Adriamycin (ADR) increases the production of reactive oxygen species (ROS), which diminishes mitochondrial function. Angiotensin-II stimulates mitochondrial ROS generation. The aim of the study was to examine whether angiotensin converting enzyme (ACE) or renin inhibitors protect against ADR-induced mitochondrial function impairment. Rats were divided into five groups as control, ADR, co-treatment ADR with captopril, co-treatment ADR with aliskiren, co-treatment ADR with both captopril and aliskiren. Left ventricular function and blood pressures were assessed at the end of treatment period. Mitochondrial membrane potential (MMP) and ATP levels were determined. ADR treatment decreased the left ventricular pressure and increased the left ventricular end-diastolic pressure. ADR decreased MMP and ATP levels in myocyte mitochondria due to increasing oxidative stress. ADR decreased MMP and ATP levels due to increased oxidative stress in the heart. Inhibitors of ACE and renin caused the elevation of the decreased of MMP and ATP levels. The pathologic changes in electrocardiogram, blood pressure and left ventricular function were decreased by inhibition of Ang-II production. We concluded that inhibitors of angiotensin II are effective against ADR cardiotoxicity via the restoration of MMP and ATP production and prevention of mitochondrial damage in vivo.
authors.affiliation: Department of Physiotherapy and Rehabilitation, School of Health Sciences, Istanbul Bilim University, Yazarlar Sokak No:17, 34394, Esentepe-Şişli/Istanbul, Turkey. eylemtaskin@yahoo.com.
authors.forename: Eylem
authors.initials: E
authors.lastname: Taskin
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Erciyes, Kayseri, Turkey.
authors.forename: Elvan Kunduz
authors.initials: EK
authors.lastname: Kindap
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Erciyes, Kayseri, Turkey.
authors.forename: Kalender
authors.initials: K
authors.lastname: Ozdogan
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, University of Erciyes, Kayseri, Turkey.
authors.forename: Mukerrem Betul Yerer
authors.initials: MBY
authors.lastname: Aycan
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Erciyes, Kayseri, Turkey.
authors.forename: Nurcan
authors.initials: N
authors.lastname: Dursun
keywords: Adriamycin; Aliskiren; Captopril; Mitochondrial ATP; Mitochondrial membrane potential; Oxidative stress index