title: Noncoding RNAs in the regulation of DNA replication.
abstract: Noncoding RNAs (ncRNAs) have crucial roles in epigenetic, transcriptional, and post-transcriptional regulation. Recent studies have begun to reveal a role of ncRNAs in DNA replication. Here, we review the roles of ncRNAs in regulating different aspects of DNA replication in prokaryotic and eukaryotic systems. We speculate that ncRNAs might function to guide the origin recognition complex (ORC) to chromosomal DNA during replication initiation in higher eukaryotes.
authors.affiliation: Yale Stem Cell Center and Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA.
authors.forename: Xin Quan
authors.initials: XQ
authors.lastname: Ge
authors.affiliation: Yale Stem Cell Center and Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: haifan.lin@yale.edu.
authors.forename: Haifan
authors.initials: H
authors.lastname: Lin
mesh_terms: D000818:Animals; D004261:DNA Replication; D005786:Gene Expression Regulation; D006801:Humans; D022661:RNA, Untranslated / Q000235:genetics*; D014158:Transcription, Genetic
chemical_list: D022661:RNA, Untranslated
keywords: DNA replication; ORC; miRNA; noncoding RNA; primer