title: Multicenter nonrandomized trial of ramosetron versus palonosetron in controlling chemotherapy-induced nausea and vomiting for colorectal cancer.
abstract: OBJECTIVE
  Chemotherapy-induced nausea and vomiting (CINV) have a negative impact on patients' quality of life and frequently pointed to as a major factor for treatment abandonment. Serotonin (5-HT3) receptor antagonist is considered as key treatment for CINV. Ramosetron and palonosetron are recently developed 5-HT3 receptor antagonists and known as more superior than other first-generation 5-HT3 receptor antagonists. The purpose of this study was to compare the efficacy of ramosetron and palonosetron and determine which drug is more effective for prevention of CINV.
  
  
  METHODS
  Colorectal cancer patients treated with chemotherapy were enrolled consecutively. Patients were assigned to receive intravenous injection of ramosetron 0.3 mg or palonosetron 0.25 mg at 30 minutes before initiation of moderately emetogenic chemotherapy. Ramosetron group added oral administration of 0.1 mg ramosetron on the second and third days of chemotherapy. Efficacy parameter consisted of nausea and vomiting.
  
  
  RESULTS
  Ninety-one patients received ramosetron and 89 patients received palonosetron. Presentation of vomiting and nausea symptoms was not significantly different between the two groups during acute (0-24 hours) and delayed period (after 24 hours).
  
  
  CONCLUSIONS
  The incidence of CINV between the ramosetron and the palonosetron group has not shown any difference during acute, delayed, and overall period.
authors.affiliation: Department of Surgery, Chungnam National University School of Medicine, Daejeon, Korea.
authors.forename: Jin Soo
authors.initials: JS
authors.lastname: Kim
authors.affiliation: Department of Surgery, Chungnam National University School of Medicine, Daejeon, Korea.
authors.forename: Ji Yeon
authors.initials: JY
authors.lastname: Kim
authors.affiliation: Department of Surgery, Chungbuk National University School of Medicine, Cheongju, Korea.
authors.forename: Sang-Jeon
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: Department of Surgery, Dankook University College of Medicine, Cheonan, Korea.
authors.forename: Dong Kook
authors.initials: DK
authors.lastname: Park
authors.affiliation: Department of Surgery, Dankook University College of Medicine, Cheonan, Korea.
authors.forename: Hwan
authors.initials: H
authors.lastname: Namgung
authors.affiliation: Department of Surgery, Eulji University School of Medicine, Daejeon, Korea.
authors.forename: Chang Nam
authors.initials: CN
authors.lastname: Kim
authors.affiliation: Department of Surgery, Konyang University College of Medicine, Daejeon, Korea.
authors.forename: Won Jun
authors.initials: WJ
authors.lastname: Choi
authors.affiliation: Department of Surgery, Sooncheonhyang University College of Medicine, Cheonan, Korea.
authors.forename: Moo Jun
authors.initials: MJ
authors.lastname: Baek
keywords: Adjuvant chemotherapy; Colorectal neoplasms; Palonosetron; Ramosetron; Vomiting