title: Lung xenotransplantation: recent progress and current status.
abstract: Xenotransplantation has undergone important progress in controlling initial hyperacute rejection in many preclinical models, with some cell, tissue, and organ xenografts advancing toward clinical trials. However, acute injury, driven primarily by innate immune and inflammatory responses, continues to limit results in lung xenograft models. The purpose of this article is to review the current status of lung xenotransplantation--including the seemingly unique challenges posed by this organ-and summarize proven and emerging means of overcoming acute lung xenograft injury.
authors.affiliation: Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA; Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD, USA.
authors.forename: Donald G
authors.initials: DG
authors.lastname: Harris
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Quinn
authors.forename: Siamak
authors.initials: S
authors.lastname: Dahi
authors.forename: Lars
authors.initials: L
authors.lastname: Burdorf
authors.forename: Agnes M
authors.initials: AM
authors.lastname: Azimzadeh
authors.forename: Richard N
authors.initials: RN
authors.lastname: Pierson
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006084:Graft Rejection / Q000276:immunology*; D006801:Humans; D008168:Lung / Q000601:surgery*; D055370:Lung Injury / Q000601:surgery*; D016040:Lung Transplantation / Q000379:methods / Q000639:trends; D014183:Transplantation, Heterologous / Q000379:methods
keywords: genetically engineered pig; immune response; lung xenotransplantation; thromboregulation