title: Effects of magnesium depletion on inflammation in chronic disease.
abstract: OBJECTIVE
  To update findings supporting the opinion that commonly occurring subclinical magnesium deficiency induced by a low dietary intake is a predisposing factor for chronic inflammatory stress that contributes to the incidence of chronic diseases such as cardiovascular disease and diabetes.
  
  
  RESULTS
  Both deficient magnesium intakes (<250 mg/day) and serum magnesium concentrations (≤ 0.75 mmol/l) have been associated with elevated serum C-reactive protein concentration, a widely used indicator of inflammation. Achieving magnesium intakes or serum magnesium concentrations that indicate an adequate magnesium status generally attenuates elevated serum C-reactive protein to concentrations that are not indicative of chronic low-grade inflammation. Individuals that are obese or have chronic diseases for which low-grade inflammation is a risk factor are commonly found to be magnesium-deficient.
  
  
  CONCLUSIONS
  Subclinical magnesium deficiency caused by low dietary intake often occurring in the population is a predisposing factor for chronic inflammatory stress that is conducive for chronic disease. Magnesium deficiency should be considered a nutrient of significant concern for health and well-being.
authors.affiliation: Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, North Dakota, USA.
authors.forename: Forrest H
authors.initials: FH
authors.lastname: Nielsen
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood / Q000150:complications; D002908:Chronic Disease; D003920:Diabetes Mellitus / Q000097:blood; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000209:etiology; D008274:Magnesium / Q000008:administration & dosage / Q000097:blood; D008275:Magnesium Deficiency / Q000097:blood / Q000150:complications*; D012307:Risk Factors
chemical_list: D002097:C-Reactive Protein; D008274:Magnesium