title: Copper-mediated aromatic amination reaction and its application to the total synthesis of natural products.
abstract: Herein, we review copper-mediated aromatic amination reactions including the classical Ullmann coupling and the recently developed mild aryl amination with an effective ligand as well as the C-H amination reaction. Several applications of intramolecular aryl amination to the syntheses of natural products demonstrate the general applicability of the reaction.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan. tokuyama@mail.pharm.tohoku.ac.jp.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Okano
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Tokuyama
authors.forename: Tohru
authors.initials: T
authors.lastname: Fukuyama
mesh_terms: D000586:Amination; D001688:Biological Products / Q000138:chemical synthesis*; D003300:Copper / Q000737:chemistry*
chemical_list: D001688:Biological Products; D003300:Copper