title: A case of neonatal myocardial infarction: left coronary artery thrombus resolution and normalisation of ventricular function by intracoronary low-dose tissue plasminogen activator.
abstract: Neonatal myocardial infarction is a rare clinical entity that is associated with high mortality. Reported treatment strategies include supportive care, extracorporeal membrane oxygenation, thrombolytics, and surgical thrombectomy. Herein we report a neonate who developed an acute myocardial infarction owing to a thrombus in the proximal left coronary artery. At 24 hours of life, he was treated with local (intracoronary) thrombolytic therapy at a lower dose than previously reported, as well as with systemic anticoagulation. There was subsequent angiographic resolution of the thrombus and normalisation of left ventricular function.
authors.affiliation: Division of Cardiology,The Children's Hospital of Philadelphia,Perelman School of Medicine and the University of Pennsylvania,Philadelphia,Pennsylvania,United States of America.
authors.forename: Anna
authors.initials: A
authors.lastname: Hallbergson
authors.affiliation: Division of Cardiology,The Children's Hospital of Philadelphia,Perelman School of Medicine and the University of Pennsylvania,Philadelphia,Pennsylvania,United States of America.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Gillespie
authors.affiliation: Division of Cardiology,The Children's Hospital of Philadelphia,Perelman School of Medicine and the University of Pennsylvania,Philadelphia,Pennsylvania,United States of America.
authors.forename: Yoav
authors.initials: Y
authors.lastname: Dori
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D006328:Cardiac Catheterization / Q000379:methods; D017023:Coronary Angiography; D003330:Coronary Vessel Anomalies; D003331:Coronary Vessels; D017984:Enoxaparin / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D009203:Myocardial Infarction / Q000150:complications / Q000175:diagnosis / Q000209:etiology*; D010960:Plasminogen Activators / Q000008:administration & dosage*; D013927:Thrombosis / Q000150:complications / Q000151:congenital / Q000628:therapy*
chemical_list: D000925:Anticoagulants; D017984:Enoxaparin; D010960:Plasminogen Activators
keywords: thrombolytics