title: Differences of urinary arsenic metabolites and methylation capacity between individuals with and without skin lesions in Inner Mongolia, Northern China.
abstract: Incomplete arsenic (As) methylation has been considered a risk factor of As-related diseases. This study aimed to examine the difference of urinary As metabolites and the methylation capacity between subjects with and without skin lesions. Urinary inorganic arsenic (iAs), monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) were analyzed. The percentage of each As species (iAs%, MMA%, and DMA%), the primary methylation index (PMI) and secondary methylation index (SMI) were calculated. The results showed that subjects with skin lesions have higher levels of urinary iAs (99.08 vs. 70.63 μg/g Cr, p = 0.006) and MMA (69.34 vs. 42.85 μg/g Cr, p = 0.016) than subjects without skin lesions after adjustment for several confounders. Significant differences of urianry MMA% (15.49 vs. 12.11, p = 0.036) and SMI (0.74 vs. 0.81, p = 0.025) were found between the two groups. The findings of the present study suggest that subjects with skin lesions may have a lower As methylation capacity than subjects without skin lesions.
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, No. 22, Qi Xiang Tai Road, Heping District, Tianjin 300070, China. qiangzhang@tijmu.edu.cn.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Environment and Non-Communicable Disease Research Center, School of Public Health, China Medical University, No. 92, Bei Er Road, Heping District, Shenyang 110001, China. liyongfang_17@163.com.
authors.forename: Yongfang
authors.initials: Y
authors.lastname: Li
authors.affiliation: Library of Tianjin Medical University, Tianjin Medical University, No. 22, Qi Xiang Tai Road, Heping District, Tianjin 300070, China. libliujuan@tijmu.edu.cn.
authors.forename: Juan
authors.initials: J
authors.lastname: Liu
authors.affiliation: Environment and Non-Communicable Disease Research Center, School of Public Health, China Medical University, No. 92, Bei Er Road, Heping District, Shenyang 110001, China. 472594283@163.com.
authors.forename: Da
authors.initials: D
authors.lastname: Wang
authors.affiliation: Environment and Non-Communicable Disease Research Center, School of Public Health, China Medical University, No. 92, Bei Er Road, Heping District, Shenyang 110001, China. qmzheng@mail.cmu.edu.cn.
authors.forename: Quanmei
authors.initials: Q
authors.lastname: Zheng
authors.affiliation: Environment and Non-Communicable Disease Research Center, School of Public Health, China Medical University, No. 92, Bei Er Road, Heping District, Shenyang 110001, China. sungf@mail.cmu.edu.cn.
authors.forename: Guifan
authors.initials: G
authors.lastname: Sun
mesh_terms: D000328:Adult; D000428:Alcohol Drinking; D001151:Arsenic / Q000652:urine*; D001152:Arsenicals / Q000652:urine*; D015992:Body Mass Index; D002101:Cacodylic Acid / Q000652:urine*; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008745:Methylation; D008875:Middle Aged; D012871:Skin Diseases / Q000453:epidemiology / Q000652:urine*; D014874:Water Pollutants, Chemical / Q000652:urine*
chemical_list: D001152:Arsenicals; D014874:Water Pollutants, Chemical; D002101:Cacodylic Acid; C020300:monomethylarsonic acid; D001151:Arsenic