title: Metabolomics in pediatric nephrology: emerging concepts.
abstract: Metabolomics, the latest of the "omics" sciences, refers to the systematic study of metabolites and their changes in biological samples due to physiological stimuli and/or genetic modification. Because metabolites represent the downstream expression of genome, transcriptome, and proteome, they can closely reflect the phenotype of an organism at a specific time. As an emerging field in analytical biochemistry, metabolomics has the potential to play a major role in monitoring real-time kidney function and detecting adverse renal events. Additionally, small molecule metabolites can provide mechanistic insights into novel biomarkers of kidney diseases, given the limitations of the current traditional markers. The clinical utility of metabolomics in the field of pediatric nephrology includes biomarker discovery, defining as yet unrecognized biological therapeutic targets, linking of metabolites to relevant standard indices and clinical outcomes, and providing a window of opportunity to investigate the intricacies of environment/genetic interplay in specific disease states.
authors.affiliation: Department of Pediatrics, University of Kentucky, Lexington, KY, USA.
authors.forename: Mina H
authors.initials: MH
authors.lastname: Hanna
authors.forename: Patrick D
authors.initials: PD
authors.lastname: Brophy
mesh_terms: D015415:Biomarkers / Q000378:metabolism*; D004059:Diffusion of Innovation; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis / Q000378:metabolism* / Q000628:therapy; D007677:Kidney Function Tests; D055432:Metabolomics / Q000639:trends*; D009398:Nephrology / Q000639:trends*; D010372:Pediatrics / Q000639:trends*; D011237:Predictive Value of Tests; D011379:Prognosis
chemical_list: D015415:Biomarkers