title: Inside and out: the activities of senescence in cancer.
abstract: The core aspect of the senescent phenotype is a stable state of cell cycle arrest. However, this is a disguise that conceals a highly active metabolic cell state with diverse functionality. Both the cell-autonomous and the non-cell-autonomous activities of senescent cells create spatiotemporally dynamic and context-dependent tissue reactions. For example, the senescence-associated secretory phenotype (SASP) provokes not only tumour-suppressive but also tumour-promoting responses. Senescence is now increasingly considered to be an integrated and widespread component that is potentially important for tumour development, tumour suppression and the response to therapy.
authors.affiliation: Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK.
authors.forename: Pedro A
authors.initials: PA
authors.lastname: Pérez-Mancera
authors.affiliation: Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK.
authors.forename: Andrew R J
authors.initials: AR
authors.lastname: Young
authors.affiliation: Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK.
authors.forename: Masashi
authors.initials: M
authors.lastname: Narita
mesh_terms: D000818:Animals; D016922:Cellular Senescence; D006801:Humans; D009369:Neoplasms / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D011230:Precancerous Conditions / Q000209:etiology / Q000473:pathology; D015398:Signal Transduction; D059016:Tumor Microenvironment