title: In vivo anticancer evaluation of the hyperthermic efficacy of anti-human epidermal growth factor receptor-targeted PEG-based nanocarrier containing magnetic nanoparticles.
abstract: Polymeric nanoparticles with targeting moieties containing magnetic nanoparticles as theranostic agents have considerable potential for the treatment of cancer. Here we report the chemical synthesis and characterization of a poly(D,L-lactide-co-glycolide)-b-poly(ethylene glycol)-based nanocarrier containing iron oxide nanoparticles and human epithelial growth factor receptor on the outer shell. The nanocarrier was also radiolabeled with (99m)Tc and tested as a theranostic nanomedicine, ie, it was investigated for both its diagnostic ability in vivo and its therapeutic hyperthermic effects in a standard A431 human tumor cell line. Following radiolabeling with (99m)Tc, the biodistribution and therapeutic hyperthermic effects of the nanosystem were studied noninvasively in vivo in tumor-bearing mice. A substantial decrease in tumor size correlated with an increase in both nanoparticle concentration and local temperature was achieved, confirming the possibility of using this multifunctional nanosystem as a therapeutic tool for epidermoid carcinoma.
authors.affiliation: CERICOL, Sovigliana-Vinci, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Baldi
authors.affiliation: CERICOL, Sovigliana-Vinci, Italy.
authors.forename: Costanza
authors.initials: C
authors.lastname: Ravagli
authors.affiliation: CERICOL, Sovigliana-Vinci, Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Mazzantini
authors.affiliation: Technological Educational Institute of Athens, Athens, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Loudos
authors.affiliation: Leitat Technological Center, Barcelona, Spain.
authors.forename: Jaume
authors.initials: J
authors.lastname: Adan
authors.affiliation: Leitat Technological Center, Barcelona, Spain.
authors.forename: Marc
authors.initials: M
authors.lastname: Masa
authors.affiliation: Technological Educational Institute of Athens, Athens, Greece.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Psimadas
authors.affiliation: Technological Educational Institute of Athens, Athens, Greece.
authors.forename: Eirini A
authors.initials: EA
authors.lastname: Fragogeorgi
authors.affiliation: Department of Industrial Chemistry Toso Montanari, University of Bologna, Bologna, Firenze, Italy.
authors.forename: Erica
authors.initials: E
authors.lastname: Locatelli
authors.affiliation: Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (INSTM), Firenze, Italy ; Dipartimento di Chimica U Schiff, Università di Firenze, Firenze, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Innocenti
authors.affiliation: Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (INSTM), Firenze, Italy ; Centro Nazionale delle Ricerche (ICCOM - CNR), Firenze, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Sangregorio
authors.affiliation: Department of Industrial Chemistry Toso Montanari, University of Bologna, Bologna, Firenze, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Comes Franchini
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D066246:ErbB Receptors / Q000737:chemistry*; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D019344:Lactic Acid / Q000737:chemistry; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D051379:Mice; D016513:Mice, SCID; D011092:Polyethylene Glycols / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D013667:Technetium / Q000737:chemistry; D014018:Tissue Distribution; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D058185:Magnetite Nanoparticles; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D011092:Polyethylene Glycols; D013667:Technetium; D066246:ErbB Receptors
keywords: hyperthermia; imaging; magnetic nanoparticles; polymeric nanocarriers; single-photon emission computed tomography; skin cancer