title: Extracellular matrix remodeling during retinal development.
abstract: The extracellular matrix (ECM) consists of a versatile and dynamic meshwork of proteoglycans and glycoproteins and plays an important functional role in complex tissues such as the developing retina. ECM forms the milieu surrounding retinal cells, constitutes basement membranes and provides structural as well as mechanical support. In addition, ECM molecules regulate the retinal homeostasis and cellular signaling. This review discusses the current state of ECM remodeling and its function during retinal development. In addition, we illustrate how ECM components control axonal growth and guidance of retinal ganglion cells and focus on ECM modulation during de- and regeneration processes.
authors.affiliation: Department of Cell Morphology and Molecular Neurobiology, Faculty of Biology and Biotechnology, Ruhr-University Bochum, Universitätsstrasse 150, 44780 Bochum, North-Rhine Westphalia, Germany.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Reinhard
authors.affiliation: Experimental Eye Research Institute, Ruhr-University Eye Hospital, In der Schornau 23-25, 44892 Bochum, North-Rhine Westphalia, Germany.
authors.forename: Stephanie C
authors.initials: SC
authors.lastname: Joachim
authors.affiliation: Department of Cell Morphology and Molecular Neurobiology, Faculty of Biology and Biotechnology, Ruhr-University Bochum, Universitätsstrasse 150, 44780 Bochum, North-Rhine Westphalia, Germany. Electronic address: andreas.faissner@rub.de.
authors.forename: Andreas
authors.initials: A
authors.lastname: Faissner
mesh_terms: D000818:Animals; D001485:Basement Membrane / Q000378:metabolism*; D005109:Extracellular Matrix / Q000502:physiology*; D006801:Humans; D009474:Neurons / Q000378:metabolism; D011509:Proteoglycans / Q000378:metabolism; D012160:Retina / Q000254:growth & development* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D011509:Proteoglycans
keywords: degeneration; development; extracellular matrix; glycoproteins; phosphacan; proteoglycans; retina; tenascin-C