title: Cytotoxic constituents from the Vietnamese fungus Xylaria schweinitzii.
abstract: Two new fungal pigments named schweinitzins A and B (1-2), together with (S)-torosachrysone-8-O-methyl ether (3) and emodin-6,8-di-O-methyl ether (4) have been isolated from the methanolic extract of the fruit bodies of Xylaria schweinitzii (Xylariaceae) collected in Cuc Phuong national park, Ninh Binh province, Vietnam, by silica gel column chromatography and preparative HPLC. Their structures were elucidated by spectroscopic analysis such as IR, UV-Vis, 2D NMR and FT-ICR-MS. In addition, two compounds (1 and 3) showed strong cytotoxicity against all four cancer cell lines, KB (a human epidermal carcinoma), MCF7 (human breast carcinoma), SK-LU-I (human lung carcinoma) and HepG2 (hepatocellular carcinoma).
authors.forename: Doan Thi Phuong
authors.initials: DT
authors.lastname: Linh
authors.forename: Bui Thi Thu
authors.initials: BT
authors.lastname: Hien
authors.forename: Do Duc
authors.initials: do D
authors.lastname: Que
authors.forename: Duong Minh
authors.initials: DM
authors.lastname: Lam
authors.forename: Norbert
authors.initials: N
authors.lastname: Arnold
authors.forename: Jürgen
authors.initials: J
authors.lastname: Schmidt
authors.forename: Andrea
authors.initials: A
authors.lastname: Porzel
authors.forename: Dang Ngoc
authors.initials: DN
authors.lastname: Quang
mesh_terms: D000873:Anthracenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014744:Vietnam; D013098:Xylariales / Q000737:chemistry*
chemical_list: C000591734:(S)-torosachrysone-8-O-methyl ether; D000873:Anthracenes; D000970:Antineoplastic Agents; D009281:Naphthalenes; C000591731:schweinitzin A; C000591733:schweinitzin B