title: Relationship between neutrophil-to-lymphocyte ratio and plaque components in patients with coronary artery disease: virtual histology intravascular ultrasound analysis.
abstract: The aim of this study was to evaluate the relation between neutrophil-to-lymphocyte ratio (NLR) and plaque components assessed by virtual histology-intravascular ultrasound in 399 coronary artery disease (CAD) patients with 471 coronary lesions. We classified the lesions into two groups according to the NLR on admission {low NLR group (NLR≤2.73 [n=370]) vs. high NLR group (NLR>2.73 [n=101])}. By volumetric analysis, total atheroma and the absolute necrotic core (NC) volumes were significantly greater in high NLR group (249.9±149.7 µL vs. 192.5±127.7 µL, P=0.001, and 32.7±26.8 µL vs. 22.8±19.4 µL, P=0.001, respectively) and thin-cap fibroatheroma (TCFA) was observed more frequently in high NLR group (33% vs. 18%, P=0.001). ST segment elevation myocardial infarction (odds ratio [OR], 2.159; 95% CI, 1.000-4.660, P=0.050) and NLR>2.73 (OR, 1.848; 95% CI, 1.016-3.360, P=0.044) and total atheroma volume (OR, 1.003; 95% CI, 1.001-1.004, P=0.004) were the independent predictors of TCFA. CAD patients with high NLR had more vulnerable plaque components (greater NC-containing plaques) than those with low NLR.
authors.affiliation: The Division of Cardiology, Chonnam National University Hospital, Gwangju, Korea. ; College of Nursing, Chonnam National University, Gwangju, Korea.
authors.forename: Yun Ha
authors.identifier: 0000-0002-0224-0062
authors.initials: YH
authors.lastname: Choi
authors.affiliation: The Division of Cardiology, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Young Joon
authors.identifier: 0000-0003-0192-8161
authors.initials: YJ
authors.lastname: Hong
authors.affiliation: The Division of Cardiology, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Youngkeun
authors.identifier: 0000-0003-2022-9366
authors.initials: Y
authors.lastname: Ahn
authors.affiliation: College of Nursing, Chonnam National University, Gwangju, Korea.
authors.forename: In Hyae
authors.identifier: 0000-0001-5113-2095
authors.initials: IH
authors.lastname: Park
authors.affiliation: The Division of Cardiology, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Myung Ho
authors.identifier: 0000-0003-4173-1494
authors.initials: MH
authors.lastname: Jeong
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006785:Hospitals, University; D006801:Humans; D008214:Lymphocytes / Q000166:cytology*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000166:cytology*; D016017:Odds Ratio; D010361:Patients; D058226:Plaque, Atherosclerotic / Q000378:metabolism / Q000473:pathology*; D012189:Retrospective Studies; D018084:Ultrasonography, Interventional
chemical_list: D002097:C-Reactive Protein
keywords: Coronary Disease; Interventional; Lymphocytes; Neutrophils; Plaque; Ultrasonography