title: Effects of low molecular weight soybean peptide on mRNA and protein expression levels of differentiation markers in normal human epidermal keratinocytes.
abstract: Low molecular weight soybean peptide (LSP) was applied to normal human epidermal keratinocytes, and the results showed a significant increase in the gene expression levels of involucrin, transglutaminase, and profilaggrin. Filaggrin protein levels were also significantly higher. It is possible that LSP has an epidermal cell differentiation-promoting effect and may be able to regulate metabolism of the epidermis.
authors.affiliation: a Laboratory of Dermatological Physiology, Faculty of Pharmaceutical Sciences , Josai University , Sakado , Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Tokudome
authors.forename: Kyosuke
authors.initials: K
authors.lastname: Nakamura
authors.forename: Fumie
authors.initials: F
authors.lastname: Hashimoto
mesh_terms: D000943:Antigens, Differentiation / Q000235:genetics* / Q000378:metabolism*; D000078404:Epidermal Cells; D000091344:Filaggrin Proteins; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects / Q000378:metabolism*; D008970:Molecular Weight; D010446:Peptide Fragments / Q000737:chemistry* / Q000494:pharmacology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D030262:Soybean Proteins / Q000737:chemistry
chemical_list: D000943:Antigens, Differentiation; C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D010446:Peptide Fragments; D012333:RNA, Messenger; D030262:Soybean Proteins
keywords: differentiation; epidermis; keratinocyte; low molecular weight soybean peptide; skin