title: Plasma β-amyloid 40 levels are positively associated with mortality risks in the elderly.
abstract: BACKGROUND
  We evaluated if plasma β-amyloid (Aβ) levels were associated with mortality risks in a subsample of the French Three-City (3C) prospective cohort study.
  
  
  METHODS
  Analyses were based on 1254 participants randomly selected from the initial 3C cohort stratified by center, sex, and age in the context of a nested case-cohort study to investigate biological variables. Associations between plasma Aβ and mortality were assessed with the Cox regression model with delayed entry including various potential confounding factors and testing possible mediators.
  
  
  RESULTS
  A relationship between high plasma Aβ1-40 concentrations and risk of mortality (hazards ratio, 1.15; 95% confidence interval, 1.01-1.31, P = .03) was unveiled independently of age, educational level, vascular risk factors, diet, physical activity, cognitive impairment, or frailty status. It was only modified when we included cystatin C levels.
  
  
  CONCLUSIONS
  Further investigations are needed to determine precisely the pathophysiological roles of plasma Aβ1-40 and cystatin C and before envisioning any future clinical applications.
authors.affiliation: Department of Neurology, Centre Mémoire Ressources Recherche Languedoc-Roussillon, CHRU Gui de Chauliac Hospital, Montpellier, France; University Montpellier 1, Montpellier, France.
authors.forename: Audrey
authors.initials: A
authors.lastname: Gabelle
authors.affiliation: Université Droit et Santé de Lille, Lille, France; CHRU de Lille, Lille, France; INSERM UMR837, Lille, France.
authors.forename: Susanna
authors.initials: S
authors.lastname: Schraen
authors.affiliation: Department of Neurology, Centre Mémoire Ressources Recherche Languedoc-Roussillon, CHRU Gui de Chauliac Hospital, Montpellier, France; INSERM U1061, Hôpital La Colombière, Montpellier, France.
authors.forename: Laure-Anne
authors.initials: LA
authors.lastname: Gutierrez
authors.affiliation: Department of Neurology, Centre Mémoire Ressources Recherche Languedoc-Roussillon, CHRU Gui de Chauliac Hospital, Montpellier, France; INSERM U1061, Hôpital La Colombière, Montpellier, France.
authors.forename: Cecile
authors.initials: C
authors.lastname: Pays
authors.affiliation: Department of Neurology, Centre Mémoire Ressources Recherche, CHRU Dijon, Dijon, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Rouaud
authors.affiliation: Université Droit et Santé de Lille, Lille, France; CHRU de Lille, Lille, France; INSERM UMR837, Lille, France.
authors.forename: Luc
authors.initials: L
authors.lastname: Buée
authors.affiliation: Department of Neurology, Centre Mémoire Ressources Recherche Languedoc-Roussillon, CHRU Gui de Chauliac Hospital, Montpellier, France; INSERM U1061, Hôpital La Colombière, Montpellier, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Touchon
authors.affiliation: INSERM 897, ISPED, Victor Segalen University, Bordeaux, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Helmer
authors.affiliation: CHRU de Lille, Lille, France; INSERM U744, Lille, France; Institut Pasteur de Lille, Lille, France; Université de Lille Nord de France, Lille, France.
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Lambert
authors.affiliation: Department of Neurology, Centre Mémoire Ressources Recherche Languedoc-Roussillon, CHRU Gui de Chauliac Hospital, Montpellier, France; INSERM U1061, Hôpital La Colombière, Montpellier, France; Université Montpellier 1, Hôpital La Colombière, Montpellier, France. Electronic address: claudine.berr@inserm.fr.
authors.forename: Claudine
authors.initials: C
authors.lastname: Berr
mesh_terms: D000368:Aged; D016229:Amyloid beta-Peptides / Q000097:blood*; D016022:Case-Control Studies; D055316:Cystatin C / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D009026:Mortality; D010446:Peptide Fragments / Q000097:blood*; D016016:Proportional Hazards Models; D011446:Prospective Studies; D011897:Random Allocation; D012306:Risk
chemical_list: D016229:Amyloid beta-Peptides; C525030:CST3 protein, human; D055316:Cystatin C; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); C075222:amyloid beta-protein (1-42)
keywords: Aging; Cystatin C; Frailty; Mild cognitive impairment due to Alzheimer's disease; Mortality risks; Plasma amyloid markers