title: Is progesteron receptor status really a prognostic factor for intracranial meningiomas?
abstract: OBJECTIVE
  Presence of steroid hormone receptors in meningiomas is well-known, but their correlation with tumour behaviour is unclear. The purpose of this study was to assess the relation between steroid hormone receptor expression and tumour behaviour.
  
  
  METHODS
  We retrospectively reviewed 48 patients undergoing surgery for intracranial meningioma between January 2002 and December 2004. We included World Health Organization (WHO) Grade I meningiomas in Group 1 and WHO Grades II and III in Group 2. Tumour grade, progesterone receptor (PR), oestrogen receptor (ER) expressions, MIB-1 Index and Mitotic Index were assessed. We sought the correlation between tumour grade and MIB-1, Mitotic Indices, and also PR expression. Furthermore, the correlation between PR expression and MIB-1 and Mitotic Indices was assessed in Group 1 and Group 2, separately.
  
  
  RESULTS
  26 patients were in Group 1 and 22 patients in Group 2. PR expression was determined in 56% of the tumours while there was no ER expression. PR expression was found to be higher in Group 1 compared to Group 2. The Mean MIB-1 Index and the Mean Mitotic Index were significantly higher in Group 2 compared to Group 1. However, when Groups 1 and 2 were assessed separately, PR expression does not appear to be correlated with MIB-1 and Mitotic Indices in benign and also in non-benign meningioma groups.
  
  
  CONCLUSIONS
  Our findings suggest that tumour grade, but not PR expression, is correlated with meningioma behaviour.
authors.affiliation: Department of Neurosurgery, Harran University Medical School, Sanliurfa, Turkey.
authors.forename: A Celal
authors.initials: AC
authors.lastname: Iplikcioglu
authors.affiliation: Department of Neurosurgery, Bezmialem Vakif University Medical School, Istanbul, Turkey. Electronic address: azizhatiboglu@yahoo.com.
authors.forename: Mustafa Aziz
authors.initials: MA
authors.lastname: Hatiboglu
authors.affiliation: Department of Neurosurgery, Okmeydani Training and Research Hospital, Istanbul, Turkey.
authors.forename: Erdinc
authors.initials: E
authors.lastname: Ozek
authors.affiliation: Department of Pathology, Okmeydani Training and Research Hospital, Istanbul, Turkey.
authors.forename: Deniz
authors.initials: D
authors.lastname: Ozcan
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D008579:Meningioma / Q000175:diagnosis / Q000378:metabolism*; D008875:Middle Aged; D008940:Mitotic Index; D060787:Neoplasm Grading; D011379:Prognosis; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism*; D012189:Retrospective Studies
chemical_list: D019394:Ki-67 Antigen; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone
keywords: MIB-1 Index; Meningioma; Mitotic Index; Oestrogen receptor; Progesterone receptor