title: Resolution of severe obstructive sleep apnea after treatment of anti-muscle kinase receptor-positive myasthenia gravis despite 60-pound weight gain.
abstract: Obstructive sleep apnea (OSA) in patients with myasthenia gravis (MG) may be caused by reduced pharyngeal dilator muscle activity. We report a patient with anti-muscle kinase receptor MG with severe OSA and hypoventilation that resolved upon successful treatment of MG despite a 60-lb weight gain.
authors.affiliation: Division of Pulmonary, Critical Care and Sleep Medicine, Hofstra North Shore-LIJ School of Medicine, New Hyde Park, NY.
authors.forename: Michael
authors.initials: M
authors.lastname: Morgenstern
authors.affiliation: Division of Pulmonary, Critical Care and Sleep Medicine, Hofstra North Shore-LIJ School of Medicine, New Hyde Park, NY.
authors.forename: Effie
authors.initials: E
authors.lastname: Singas
authors.affiliation: Division of Pulmonary, Critical Care and Sleep Medicine, Hofstra North Shore-LIJ School of Medicine, New Hyde Park, NY.
authors.forename: Bashar
authors.initials: B
authors.lastname: Zleik
authors.affiliation: Division of Pulmonary, Critical Care and Sleep Medicine, Hofstra North Shore-LIJ School of Medicine, New Hyde Park, NY.
authors.forename: Harly
authors.initials: H
authors.lastname: Greenberg
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000150:complications* / Q000628:therapy*; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D010951:Plasma Exchange / Q000379:methods*; D011241:Prednisone / Q000627:therapeutic use; D020181:Sleep Apnea, Obstructive / Q000150:complications*; D016896:Treatment Outcome; D015430:Weight Gain
chemical_list: D000893:Anti-Inflammatory Agents; D009173:Mycophenolic Acid; D011241:Prednisone
keywords: anti-musk antibody; hypoventilation; myasthenia gravis; obstructive sleep apnea