title: Anti arthritic and anti inflammatory activity of a cytotoxic protein NN-32 from Indian spectacle cobra (Naja naja) venom in male albino rats.
abstract: The anti arthritic and anti inflammatory activity of NN-32, a cytotoxic protein from Indian spectacle cobra snake (Naja naja) venom has been studied in Freund's complete adjuvant (FCA) induced arthritis and carrageenan induced anti inflammatory model. NN-32 treatment showed significant decrease in physical and urinary parameters, serum enzymes, serum cytokines levels as compared to arthritic control group of rats. NN-32 treatment recovered carrageenan induced inflammation as compared to control group of rats. The findings showed that the cytotoxic protein NN-32 shares anti arthritic and anti inflammatory activity and thus NN-32 may target complex pathophysiological processes like cancer- arthritis-inflammation.
authors.affiliation: Laboratory of Toxinology & Experimental Pharmacodynamics, Department of Physiology, University of Calcutta, 92, A P C Road, Kolkata 700 009, India. Electronic address: agomescu@gmail.com.
authors.forename: Antony
authors.initials: A
authors.lastname: Gomes
authors.affiliation: Laboratory of Toxinology & Experimental Pharmacodynamics, Department of Physiology, University of Calcutta, 92, A P C Road, Kolkata 700 009, India.
authors.forename: Poulami
authors.initials: P
authors.lastname: Datta
authors.affiliation: Laboratory of Toxinology & Experimental Pharmacodynamics, Department of Physiology, University of Calcutta, 92, A P C Road, Kolkata 700 009, India.
authors.forename: Tanaya
authors.initials: T
authors.lastname: Das
authors.affiliation: Laboratory of Toxinology & Experimental Pharmacodynamics, Department of Physiology, University of Calcutta, 92, A P C Road, Kolkata 700 009, India.
authors.forename: Ajoy Kumar
authors.initials: AK
authors.lastname: Biswas
authors.affiliation: Laboratory of Toxinology & Experimental Pharmacodynamics, Department of Physiology, University of Calcutta, 92, A P C Road, Kolkata 700 009, India.
authors.forename: Aparna
authors.initials: A
authors.lastname: Gomes
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001168:Arthritis / Q000188:drug therapy*; D004546:Elapid Venoms / Q000737:chemistry*; D017815:Elapidae; D008297:Male; D011506:Proteins / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats
chemical_list: D000893:Anti-Inflammatory Agents; D004546:Elapid Venoms; D011506:Proteins
keywords: Cytotoxic protein; Indian Naja naja venom; Rheumatoid arthritis