title: Two-stage treatment with hepatectomy and carbon-ion radiotherapy for multiple hepatic epithelioid hemangioendotheliomas.
abstract: Hepatic epithelioid hemangioendothelioma (HEH) is a rare neoplasm of vascular origin with variable malignant potential. Because most patients with this condition have multiple bilobar lesions, liver transplantation is the standard treatment, and hepatectomy is much less frequently indicated. We describe a case of a 35-year-old woman with unresectable multiple bilobar HEH successfully treated by combination treatment with hepatectomy and carbon-ion radiotherapy. This case is very meaningful since it demonstrated the effectiveness of carbon-ion radiotherapy for HEH and the possibility of expanding the curative treatment options for multiple bilobar hepatic tumors.
authors.affiliation: Shohei Komatsu, Atsushi Takebe, Takumi Fukumoto, Yonson Ku, Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Hyogo 650-0017, Japan.
authors.forename: Shohei
authors.initials: S
authors.lastname: Komatsu
authors.affiliation: Shohei Komatsu, Atsushi Takebe, Takumi Fukumoto, Yonson Ku, Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Hyogo 650-0017, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Iwasaki
authors.affiliation: Shohei Komatsu, Atsushi Takebe, Takumi Fukumoto, Yonson Ku, Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Hyogo 650-0017, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Demizu
authors.affiliation: Shohei Komatsu, Atsushi Takebe, Takumi Fukumoto, Yonson Ku, Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Hyogo 650-0017, Japan.
authors.forename: Kazuki
authors.initials: K
authors.lastname: Terashima
authors.affiliation: Shohei Komatsu, Atsushi Takebe, Takumi Fukumoto, Yonson Ku, Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Hyogo 650-0017, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Fujii
authors.affiliation: Shohei Komatsu, Atsushi Takebe, Takumi Fukumoto, Yonson Ku, Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Hyogo 650-0017, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takebe
authors.affiliation: Shohei Komatsu, Atsushi Takebe, Takumi Fukumoto, Yonson Ku, Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Hyogo 650-0017, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Toyokawa
authors.affiliation: Shohei Komatsu, Atsushi Takebe, Takumi Fukumoto, Yonson Ku, Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Hyogo 650-0017, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Teramura
authors.affiliation: Shohei Komatsu, Atsushi Takebe, Takumi Fukumoto, Yonson Ku, Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Hyogo 650-0017, Japan.
authors.forename: Takumi
authors.initials: T
authors.lastname: Fukumoto
authors.affiliation: Shohei Komatsu, Atsushi Takebe, Takumi Fukumoto, Yonson Ku, Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Hyogo 650-0017, Japan.
authors.forename: Yonson
authors.initials: Y
authors.lastname: Ku
authors.affiliation: Shohei Komatsu, Atsushi Takebe, Takumi Fukumoto, Yonson Ku, Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Hyogo 650-0017, Japan.
authors.forename: Nobukazu
authors.initials: N
authors.lastname: Fuwa
mesh_terms: D000328:Adult; D001706:Biopsy; D005260:Female; D063193:Heavy Ion Radiotherapy; D018323:Hemangioendothelioma, Epithelioid / Q000473:pathology / Q000628:therapy*; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000628:therapy*; D009378:Neoplasms, Multiple Primary / Q000473:pathology / Q000628:therapy*; D018714:Radiotherapy, Adjuvant; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
keywords: Carbon-ion radiotherapy; Hepatectomy; Hepatic epithelioid hemangioendothelioma; Omental flap spacer; Particle radiotherapy; Two-stage treatment