title: Glutathione-coated luminescent gold nanoparticles: a surface ligand for minimizing serum protein adsorption.
abstract: Ultrasmall glutathione-coated luminescent gold nanoparticles (GS-AuNPs) are known for their high resistance to serum protein adsorption. Our studies show that these NPs can serve as surface ligands to significantly enhance the physiological stability and lower the serum protein adsorption of superparamagnetic iron oxide nanoparticles (SPIONs), in addition to rendering the NPs the luminescence property. After the incorporation of GS-AuNPs onto the surface of SPIONs to form the hybrid nanoparticles (HBNPs), these SPIONs' protein adsorption was about 10-fold lower than those of the pure glutathione-coated SPIONs suggesting that GS-AuNPs are capable of providing a stealth effect against serum proteins.
authors.affiliation: Department of Chemistry, The University of Texas at Dallas , Richardson, Texas 75080, United States.
authors.forename: Rodrigo D
authors.initials: RD
authors.lastname: Vinluan
authors.forename: Jinbin
authors.initials: J
authors.lastname: Liu
authors.forename: Chen
authors.initials: C
authors.lastname: Zhou
authors.forename: Mengxiao
authors.initials: M
authors.lastname: Yu
authors.forename: Shengyang
authors.initials: S
authors.lastname: Yang
authors.forename: Amit
authors.initials: A
authors.lastname: Kumar
authors.forename: Shasha
authors.initials: S
authors.lastname: Sun
authors.forename: Andrew
authors.initials: A
authors.lastname: Dean
authors.forename: Xiankai
authors.initials: X
authors.lastname: Sun
authors.forename: Jie
authors.initials: J
authors.lastname: Zheng
mesh_terms: D000327:Adsorption; D001798:Blood Proteins / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D003911:Dextrans / Q000737:chemistry*; D005978:Glutathione / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D006801:Humans; D008024:Ligands; D049449:Luminescence; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D050997:Nanomedicine; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D013696:Temperature
chemical_list: D001798:Blood Proteins; D020099:Coated Materials, Biocompatible; D003911:Dextrans; D008024:Ligands; D058185:Magnetite Nanoparticles; D006046:Gold; C065507:ferumoxides; D005978:Glutathione