title: Endoplasmic reticulum stress: relevance and therapeutics in central nervous system diseases.
abstract: Endoplasmic reticulum (ER) stress plays an important role in a range of neurological disorders, such as neurodegenation diseases, cerebral ischemia, spinal cord injury, sclerosis, and diabetic neuropathy. Protein misfolding and accumulation in the ER lumen initiate unfolded protein response in energy-starved neurons which are relevant to toxic effects. In neurological disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, ER dysfunction is well recognized, but the mechanisms remain unclear. In stroke and ischemia, spinal cord injury, and amyotrophic lateral sclerosis, chronic activation of ER stress is considered as main pathogeny which causes neuronal disorders. By targeting components of these ER signaling responses, to explore clinical treatment strategies or new drugs in CNS neurological diseases might become possible and valuable in the future.
authors.affiliation: School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University, Wenzhou, 325035, China.
authors.forename: Hong-Yu
authors.initials: HY
authors.lastname: Zhang
authors.forename: Zhou-guang
authors.initials: ZG
authors.lastname: Wang
authors.forename: Xiang-Hong
authors.initials: XH
authors.lastname: Lu
authors.forename: Xiao-Xia
authors.initials: XX
authors.lastname: Kong
authors.forename: Fen-Zan
authors.initials: FZ
authors.lastname: Wu
authors.forename: Li
authors.initials: L
authors.lastname: Lin
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Tan
authors.forename: Li-Bing
authors.initials: LB
authors.lastname: Ye
authors.forename: Jian
authors.initials: J
authors.lastname: Xiao
mesh_terms: D000818:Animals; D002493:Central Nervous System Diseases / Q000378:metabolism* / Q000473:pathology / Q000628:therapy*; D004721:Endoplasmic Reticulum / Q000378:metabolism* / Q000473:pathology; D059865:Endoplasmic Reticulum Stress / Q000502:physiology*; D006801:Humans; D009474:Neurons / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D056811:Unfolded Protein Response / Q000502:physiology