title: [Influence of nonsteroidal anti-inflammatory drugs on chemiluminescence of polymorphonuclear leukocytes in patients with intolerance of these drugs].
abstract: We have studied the intensity of barium sulfate stimulated luminol- and lucigenin-dependent chemiluminescence (SLCHL and SLCCHL) in polymorphonuclear leukocytes (PML) after pre-incubation of PML suspension with sodium salicylate, sodium metamizole, or sodium diclofenac at various concentrations in healthy donors and patients with intolerance to aspirin, and/or sodium metamizole, and/or sodium diclofenac. No significant differences of SLCHL and SLCCHL indicators in PML isolated from healthy donors and patients with intolerance to these drugs have been found, which indirectly indicates the absence of any specific features in the oxidative metabolism of PML enzymes under the influence of indicated NSAIDs in patients intolerant of these drugs as compared to donors.
mesh_terms: D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004342:Drug Hypersensitivity / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000378:metabolism* / Q000473:pathology; D049449:Luminescence; D008297:Male; D008875:Middle Aged
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal