title: Outcomes of autologous bone marrow mononuclear cell transplantation in decompensated liver cirrhosis.
abstract: OBJECTIVE
  To determine the long-term efficacy of autologous bone marrow mononuclear cells (BM-MNCs) transplantation in terms of improving liver function and reducing complications in patients with decompensated cirrhosis.
  
  
  METHODS
  A total of 47 inpatients with decompensated liver cirrhosis were enrolled in this trial, including 32 patients undergoing a single BM-MNCs transplantation plus routine medical treatment, and 15 patients receiving medical treatment only as controls. Forty-three of 47 patients were infected with hepatitis B virus. Bone marrow of 80-100 mL was obtained from each patient and the BM-MNCs suspension was transfused into the liver via the hepatic artery. The efficacy of BM-MNCs transplantation was monitored during a 24-mo follow-up period.
  
  
  RESULTS
  Liver function parameters in the two groups were observed at 1 mo after BM-MNCs transfusion. Prealbumin level was 118.3 ± 25.3 mg/L vs 101.4 ± 28.7 mg/L (P = 0.047); albumin level was 33.5 ± 3.6 g/L vs 30.3 ± 2.2 g/L (P = 0.002); total bilirubin 36.9 ± 9.7 mmol/L vs 45.6 ± 19.9 mmol/L (P = 0.048); prothrombin time 14.4 ± 2.3 s vs 15.9 ± 2.8 s (P = 0.046); prothrombin activity 84.3% ± 14.3% vs 74.4% ± 17.8% (P = 0.046); fibrinogen 2.28 ± 0.53 g/L vs 1.89 ± 0.44 g/L (P = 0.017); and platelet count 74.5 ± 15.7 × 10(9)/L vs 63.3 ± 15.7 × 10(9)/L (P = 0.027) in the treatment group and control group, respectively. Differences were statistically significant. The efficacy of BM-MNCs transplantation lasted 3-12 mo as compared with the control group. Serious complications such as hepatic encephalopathy and spontaneous bacterial peritonitis were also significantly reduced in BM-MNCs transfused patients compared with the controls. However, these improvements disappeared 24 mo after transplantation.
  
  
  CONCLUSIONS
  BM-MNCs transplantation is safe and effective in patients with decompensated cirrhosis. It also decreases the incidence of serious complications.
authors.affiliation: Yang-Qiu Bai, Yu-Xiu Yang, Song-Ze Ding, Ming-Bo Cao, Yan-Rui Zhang, Bing-Yong Zhang, Department of Gastroenterology and Hepatology, Zhengzhou University People's Hospital, Zhengzhou 450003, Henan Province, China.
authors.forename: Yang-Qiu
authors.initials: YQ
authors.lastname: Bai
authors.affiliation: Yang-Qiu Bai, Yu-Xiu Yang, Song-Ze Ding, Ming-Bo Cao, Yan-Rui Zhang, Bing-Yong Zhang, Department of Gastroenterology and Hepatology, Zhengzhou University People's Hospital, Zhengzhou 450003, Henan Province, China.
authors.forename: Yu-Xiu
authors.initials: YX
authors.lastname: Yang
authors.affiliation: Yang-Qiu Bai, Yu-Xiu Yang, Song-Ze Ding, Ming-Bo Cao, Yan-Rui Zhang, Bing-Yong Zhang, Department of Gastroenterology and Hepatology, Zhengzhou University People's Hospital, Zhengzhou 450003, Henan Province, China.
authors.forename: Ya-Ge
authors.initials: YG
authors.lastname: Yang
authors.affiliation: Yang-Qiu Bai, Yu-Xiu Yang, Song-Ze Ding, Ming-Bo Cao, Yan-Rui Zhang, Bing-Yong Zhang, Department of Gastroenterology and Hepatology, Zhengzhou University People's Hospital, Zhengzhou 450003, Henan Province, China.
authors.forename: Song-Ze
authors.initials: SZ
authors.lastname: Ding
authors.affiliation: Yang-Qiu Bai, Yu-Xiu Yang, Song-Ze Ding, Ming-Bo Cao, Yan-Rui Zhang, Bing-Yong Zhang, Department of Gastroenterology and Hepatology, Zhengzhou University People's Hospital, Zhengzhou 450003, Henan Province, China.
authors.forename: Fang-Li
authors.initials: FL
authors.lastname: Jin
authors.affiliation: Yang-Qiu Bai, Yu-Xiu Yang, Song-Ze Ding, Ming-Bo Cao, Yan-Rui Zhang, Bing-Yong Zhang, Department of Gastroenterology and Hepatology, Zhengzhou University People's Hospital, Zhengzhou 450003, Henan Province, China.
authors.forename: Ming-Bo
authors.initials: MB
authors.lastname: Cao
authors.affiliation: Yang-Qiu Bai, Yu-Xiu Yang, Song-Ze Ding, Ming-Bo Cao, Yan-Rui Zhang, Bing-Yong Zhang, Department of Gastroenterology and Hepatology, Zhengzhou University People's Hospital, Zhengzhou 450003, Henan Province, China.
authors.forename: Yan-Rui
authors.initials: YR
authors.lastname: Zhang
authors.affiliation: Yang-Qiu Bai, Yu-Xiu Yang, Song-Ze Ding, Ming-Bo Cao, Yan-Rui Zhang, Bing-Yong Zhang, Department of Gastroenterology and Hepatology, Zhengzhou University People's Hospital, Zhengzhou 450003, Henan Province, China.
authors.forename: Bing-Yong
authors.initials: BY
authors.lastname: Zhang
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001780:Blood Coagulation Tests; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D002681:China; D005260:Female; D006509:Hepatitis B / Q000150:complications; D006801:Humans; D008099:Liver / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery*; D008103:Liver Cirrhosis / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery* / Q000821:virology; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood / Q000503:physiopathology / Q000601:surgery; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D020127:Recovery of Function; D013997:Time Factors; D014182:Transplantation, Autologous; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers
keywords: Autologous; Bone marrow mononuclear cells; Hepatitis B virus; Liver cirrhosis; Transplantation