title: Tissue specific uptake and elimination of perfluoroalkyl acids (PFAAs) in adult rainbow trout (Oncorhynchus mykiss) after dietary exposure.
abstract: Tissue specific uptake and elimination of perfluoroalkyl acids (PFAAs) were studied in rainbow trout (Oncorhynchus mykiss). Adult trout were exposed to perfluorobutane sulfonic acid (PFBS), perfluorohexane sulfonic acid (PFHxS), perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA) and perfluorononanoic acid (PFNA) via food over a time period of 28d. In the following 28-d depuration period the fish were fed PFAA-free food. At defined sampling times four animals were removed from the experimental tank, euthanized and dissected. Muscle, liver, kidneys, gills, blood, skin and carcass were examined individually. At the end of the accumulation phase between 0.63% (PFOA) and 15.5% (PFOS) of the absolute, applied quantity of PFAAs was recovered in the whole fish. The main target organ was the liver with recovery rates between 0.11% (PFBS) and 4.01% (PFOS) of the total amount of ingested PFAAs. Perfluoroalkyl sulfonic acids were taken up more readily and had longer estimated elimination half-lives than perfluoroalkyl carboxylic acids of the same chain length. The longest estimated elimination half-lives were found to be for PFOS between 8.4d in muscle tissue and 20.4d in the liver and for PFNA between 8.2d in the blood and 11.6d in the liver.
authors.affiliation: Hessian State Laboratory, Glarusstr. 6, 65203 Wiesbaden, Germany. Electronic address: sandy.falk@lhl.hessen.de.
authors.forename: Sandy
authors.initials: S
authors.lastname: Falk
authors.affiliation: Unit for Biomathematics and Data Processing, Faculty of Veterinary Medicine, University of Giessen, Frankfurter Str. 95, 35392 Giessen, Germany. Electronic address: klaus.failing@vetmed.uni-giessen.de.
authors.forename: Klaus
authors.initials: K
authors.lastname: Failing
authors.affiliation: Hessian State Laboratory, Glarusstr. 6, 65203 Wiesbaden, Germany. Electronic address: sebastian.georgii@lhl.hessen.de.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Georgii
authors.affiliation: Hessian State Laboratory, Schubertstr. 60, 35392 Giessen, Germany. Electronic address: hubertus.brunn@ernaehrung.uni-giessen.de.
authors.forename: Hubertus
authors.initials: H
authors.lastname: Brunn
authors.affiliation: Hessian State Laboratory, Glarusstr. 6, 65203 Wiesbaden, Germany. Electronic address: thorsten.stahl@lhl.hessen.de.
authors.forename: Thorsten
authors.initials: T
authors.lastname: Stahl
mesh_terms: D017738:Alkanesulfonic Acids / Q000378:metabolism*; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004032:Diet; D004781:Environmental Exposure; D004784:Environmental Monitoring; D005466:Fluorocarbons / Q000378:metabolism*; D006207:Half-Life; D009132:Muscles / Q000378:metabolism; D017686:Oncorhynchus mykiss / Q000378:metabolism*; D053719:Tandem Mass Spectrometry; D014018:Tissue Distribution; D014874:Water Pollutants, Chemical / Q000378:metabolism*
chemical_list: D017738:Alkanesulfonic Acids; D005466:Fluorocarbons; D014874:Water Pollutants, Chemical
keywords: Dietary exposure; Elimination half-life; PFAAs; Rainbow trout; Tissue specific uptake