title: New use for old drugs? Prospective targets of chloroquines in cancer therapy.
abstract: During the last decade research is gradually repositioning the antimalarial drug chloroquine, and certain related quinoline derivatives, as anticancer agents. Chloroquine and hydroxychloroquine, in particular, have relatively well-characterized toxicity profiles due to several decades of use for treatment of malaria. Previously published review articles provide an excellent overview of the diversity of chloroquine effects on cancer cells, both in the cell culture as well as on human tumors grafted into mice; and an account of the increasing pace of incorporation of hydroxychloroquine in combination treatment schemes for clinical studies. In this review we present some features that are common between cancers that are sensitive to quinoline derivatives, in particular features that are amenable to pharmaceutical intervention.
authors.forename: Spiros
authors.initials: S
authors.lastname: Vlahopoulos
authors.forename: Elena
authors.initials: E
authors.lastname: Critselis
authors.forename: Ioannis F
authors.initials: IF
authors.lastname: Voutsas
authors.forename: Sonia A
authors.initials: SA
authors.lastname: Perez
authors.forename: Maria
authors.initials: M
authors.lastname: Moschovi
authors.forename: Constantin N
authors.initials: CN
authors.lastname: Baxevanis
authors.affiliation: Horemio Research Institute, First Department of Pediatrics, University of Athens Medical School, "Aghia Sophia" Children's Hospital, Thivon & Levadias, 11527 Goudi, Athens, Greece. sblachop@med.uoa.gr.
authors.forename: George P
authors.initials: GP
authors.lastname: Chrousos
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D014411:Neoplastic Stem Cells / Q000187:drug effects; D061988:Proteasome Inhibitors / Q000627:therapeutic use
chemical_list: D000962:Antimalarials; D061988:Proteasome Inhibitors; D002738:Chloroquine