title: Toxic interaction between Th2 cytokines and Staphylococcus aureus in atopic dermatitis.
abstract: Patients with atopic dermatitis (AD) are commonly colonized/infected with Staphylococcus aureus, and this bacterium is known to worsen the dermatitis. In this issue, Brauweiler et al. demonstrate a newly discovered mechanism by which Th2 cytokines involved in AD augment the toxicity of the lytic staphylococcal protein alpha toxin. This review presents mechanisms by which Th2 cytokines may interact with S. aureus to the detriment of the dermatitis.
authors.affiliation: Richard L. Roudebush VA Medical Center, Indianapolis, Indiana, USA; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, USA. Electronic address: jtravers@iupui.edu.
authors.forename: Jeffrey B
authors.initials: JB
authors.lastname: Travers
mesh_terms: D001427:Bacterial Toxins / Q000494:pharmacology*; D016207:Cytokines / Q000494:pharmacology*; D006460:Hemolysin Proteins / Q000494:pharmacology*; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects*; D050800:STAT6 Transcription Factor / Q000502:physiology*; D018418:Th2 Cells / Q000276:immunology*
chemical_list: D001427:Bacterial Toxins; D016207:Cytokines; D006460:Hemolysin Proteins; D050800:STAT6 Transcription Factor; C494101:STAT6 protein, human; C021091:staphylococcal alpha-toxin