title: 11C-mHED for PET / CT: principles of synthesis, methodology and first clinical applications.
abstract: Alterations of the cardiac autonomic nervous system play an important role in the pathway of many heart diseases. Nuclear imaging tools have been demonstrated to be useful for global and regional assessment of myocardial innervation. We used (11)C-meta-hydroxy-ephedrine ((11)C-mHED), a catecholamine analogue, as a radiotracer usable with a PET/CT scanner to study the cardiac sympathetic system. After a fast and automatic synthesis of mHED and its labeling with (11)C, we acquired cardiac images by using a PET/ CT scanner. In this paper we present our preliminary results showing the radiotracer bio-distribution in humans 10 minutes post injection. The present study assesses the feasibility of PET/CT with the radiolabeled catecholamine analogue ((11)C-mHED) in order to determine sympathetic innervation in the human heart.
authors.forename: Rachele
authors.initials: R
authors.lastname: Bonfiglioli
authors.forename: Cristina
authors.initials: C
authors.lastname: Nanni
authors.forename: Cristian
authors.initials: C
authors.lastname: Martignani
authors.forename: Lucia
authors.initials: L
authors.lastname: Zanoni
authors.forename: Raffaele
authors.initials: R
authors.lastname: La Donna
authors.forename: Igor
authors.initials: I
authors.lastname: Diemberger
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Boriani
authors.forename: Cinzia
authors.initials: C
authors.lastname: Pettinato
authors.forename: Gianmario
authors.initials: G
authors.lastname: Sambuceti
authors.forename: Stefano
authors.initials: S
authors.lastname: Fanti
authors.affiliation: Nuclear Medicine Department, S. Orsola-Malpighi Hospital, Bologna, Italy. rachele.bonfiglioli@gmail.com.
authors.forename: Luigi
authors.initials: L
authors.lastname: Mansi
mesh_terms: D001342:Autonomic Nervous System Diseases / Q000000981:diagnostic imaging*; D002250:Carbon Radioisotopes; D004305:Dose-Response Relationship, Drug; D004809:Ephedrine / Q000031:analogs & derivatives*; D006321:Heart / Q000000981:diagnostic imaging / Q000294:innervation*; D006331:Heart Diseases / Q000000981:diagnostic imaging*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D009206:Myocardium / Q000378:metabolism*; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; C065363:3-hydroxyephedrine; D004809:Ephedrine