title: The diagnostic efficacy of nectin 4 expression in ovarian cancer patients.
abstract: BACKGROUND
  Nectin 4 plays a significant role in cancer cell growth and invasion.
  
  
  OBJECTIVE
  To explore its diagnostic role in ovarian cancer.
  
  
  METHODS
  Evaluation of nectin 4 expression in ovarian biopsies by real-time PCR and serum nectin 4 and CA-125 by ELISA in 39 ovarian cancer patients, 21 females with benign ovarian neoplasms and 25 control females.
  
  
  RESULTS
  Nectin 4 expression was significantly higher in ovarian cancer patients and it was significantly correlated to serum nectin 4 and CA-125.
  
  
  CONCLUSIONS
  Ovarian tissue expression and serum nectin 4 appear to be potential markers in ovarian cancer.
authors.affiliation: Department of Medical Biochemistry and.
authors.forename: Enas Samir
authors.initials: ES
authors.lastname: Nabih
authors.forename: Fayda Ibrahim
authors.initials: FI
authors.lastname: Abdel Motaleb
authors.forename: Fekria Ahmed
authors.initials: FA
authors.lastname: Salama
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D015815:Cell Adhesion Molecules / Q000097:blood* / Q000235:genetics; D005260:Female; D006801:Humans; D008875:Middle Aged; D018297:Neoplasms, Cystic, Mucinous, and Serous / Q000097:blood*; D010051:Ovarian Neoplasms / Q000097:blood*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012372:ROC Curve; D000075983:Nectins
chemical_list: D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules; D012333:RNA, Messenger; C442228:NECTIN4 protein, human; D000075983:Nectins
keywords: CA-125; marker; nectin 4; ovarian cancer