title: Autoinflammatory syndromes for the dermatologist.
abstract: While autoimmunity as cause of disease is well-established, other categories of immune-mediated diseases that are not produced by targeting of self-antigens by antibodies is in the process of being described. These so-called autoinflammatory diseases arise when an inappropriate activation of antigen-independent mechanisms occurs. Autoinflammatory diseases course with recurrent attacks of fever and multisystemic inflammation; however, the skin may also be affected by a variety of inflammatory manifestations that often alert the clinician about the presence of an autoinflammatory disease. Recognizing the cutaneous features of these syndromes will aid for prompt diagnosis and early treatment that is key for the quality of life and survival of the affected patients. In this paper, we focus on the skin manifestations of autoinflammatory diseases in children, which is the usual period of appearing of the first symptoms and signs.
authors.affiliation: Department of Dermatology, Hospital del Niño Jesús, Menéndez Pelayo 65, 28009 Madrid, Spain.
authors.forename: Paula
authors.initials: P
authors.lastname: Dávila-Seijo
authors.affiliation: Department of Dermatology, Hospital del Niño Jesús, Menéndez Pelayo 65, 28009 Madrid, Spain.
authors.forename: Angela
authors.initials: A
authors.lastname: Hernández-Martín
authors.affiliation: Department of Dermatology, Hospital del Niño Jesús, Menéndez Pelayo 65, 28009 Madrid, Spain. Electronic address: atorrelo@aedv.es.
authors.forename: Antonio
authors.initials: A
authors.lastname: Torrelo
mesh_terms: D001327:Autoimmune Diseases / Q000150:complications / Q000175:diagnosis* / Q000276:immunology*; D015551:Autoimmunity / Q000276:immunology*; D002648:Child; D003880:Dermatology / Q000592:standards; D006304:Health Status; D056660:Hereditary Autoinflammatory Diseases / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D007249:Inflammation / Q000276:immunology; D012871:Skin Diseases / Q000150:complications / Q000175:diagnosis* / Q000276:immunology*