title: Follow-up of children with hemoglobinopathies diagnosed by the Brazilian Neonatal Screening Program in the State of Pernambuco.
abstract: OBJECTIVE
  To determine the geographical distribution of hemoglobinopathies in the State of Pernambuco, to characterize the children with these diseases and to describe factors associated with their follow-up at the referral center during the period from 2003 to 2010.
  
  
  METHODS
  A retrospective, cross-sectional, descriptive study was carried out of 275 medical records from a total of 302 children with hemoglobinopathies diagnosed by the National Neonatal Screening Program in the State of Pernambuco in the study period. Microsoft Excel was used for data processing and analysis. The chi-square and the Fisher test were used for statistical analysis. The level of significance was set at 5%. Terra View software was used to analyze the geographical distribution of hemoglobinopathies in the State.
  
  
  RESULTS
  A total of 8.9% of the cases of hemoglobinopathies detected in the period were not followed up at the referral center. For the mothers of children with diseases, this was their second or third or more pregnancy in 64.2% and 30.2%, respectively. Regarding the influence of region of residence and regular medical appointments, the study demonstrated that children from the Zona da Mata, Sertão and Vale do São Francisco regions did not attend 45.2%, 50% and 55.6% of their appointments in the outpatient department, respectively.
  
  
  CONCLUSIONS
  This study shows that a significant number of children do not begin consultations in the outpatient clinic and even those who started treatment early and who have the most severe form of the disease, usually miss medical appointments.
authors.affiliation: Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, PE, Brazil. Electronic address: acarolns@hotmail.com.
authors.forename: Ana Caroline Novaes
authors.initials: AC
authors.lastname: Soares
authors.affiliation: Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, PE, Brazil.
authors.forename: Isabella Chagas
authors.initials: IC
authors.lastname: Samico
authors.affiliation: Fundação de Hematologia e Hemoterapia de Pernambuco (HEMOPE), Recife, PE, Brazil.
authors.forename: Aderson Silva
authors.initials: AS
authors.lastname: Araújo
authors.affiliation: Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil.
authors.forename: Marcos André C
authors.initials: MA
authors.lastname: Bezerra
authors.affiliation: Fundação de Hematologia e Hemoterapia de Pernambuco (HEMOPE), Recife, PE, Brazil.
authors.forename: Betânia Lucena Domingues
authors.initials: BL
authors.lastname: Hatzlhofer
keywords: Hemoglobin SC disease; Hemoglobinopathies; Neonatal screening