title: Eosinophil count is related with coronary thrombus in non ST-elevated acute coronary syndrome.
abstract: BACKGROUND
  White blood cells are reported as important not only in plaque vulnerability but also in thrombus formation and thrombus growth in acute coronary syndromes. Eosinophils contain granules that promote thrombus formation and thrombus growth in some heart diseases. In this study we aimed to investigate the relation of eosinophil count with coronary thrombus formation in patients with non ST-elevated acute coronary syndrome (NST-ACS).
  
  
  METHODS
  A total of 251 consecutive patients were hospitalized in our hospital with a diagnosis of NST-ACS. Venous blood is collected for measurement of hematologic indices in all patients undergoing the coronary angiography. Coronary angiographies were performed in our clinic using the standard Judkins technique and angiographic assessment of the presence of thrombus was made.
  
  
  RESULTS
  During coronary angiography, coronary thrombus was not detected in 82 patients (Group 1). In the coronary angiography of 169 patients, coronary thrombus was detected at various grades (Group 2). While the neutrophil count (6.84±1.94 vs. 5.53±1.37; P<0.001) and eosinophil count (0.257±0.125 vs. 0.163±0.114; P<0.005) was significnatly increased in the group with coronary thrombus, the lymphocyte count (1.87±0.66 vs. 2.00±0.70; P<0.001) was significantly decreased in the group with coronary thrombus as compared to the patient group without coronary thrombus. In the correlation analyzes; presence of coronary thrombus is correlated with total cholesterol, LDL-C, total CK, CK-MB, troponin, total number of diseased coronary, platelet count, neutrophil count, lymphocyte count and eosinophil count. On multivariate linear regression analysis, total leukocyte count, neutrophil count, lymphocyte count, eosinophil count, troponin and total cholesterol was found to be independent predictor of coronary thrombus in patients with NST-ACS.
  
  
  CONCLUSIONS
  Beside the increased neutrophil count, increased eosinophil count in CBC should alert the clinician about coronary thrombus development in patients with NST-ACS in order to make early medical interventions at acute phase of the disease.
authors.affiliation: Department of Cardiology, Bursa Yuksek Ihtisas Education and Resarch Hospital, Bursa, Turkey.
authors.forename: Erhan
authors.initials: E
authors.lastname: Tenekecioglu
authors.affiliation: Department of Cardiology, Bursa Yuksek Ihtisas Education and Resarch Hospital, Bursa, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yilmaz
authors.affiliation: Department of Cardiology, Canakkale Onsekiz Mart University, Canakkale, Turkey.
authors.forename: Adem
authors.initials: A
authors.lastname: Bekler
authors.affiliation: Department of Cardiology, Adana State Hospital, Adana, Turkey.
authors.forename: Serafettin
authors.initials: S
authors.lastname: Demir
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging; D008078:Cholesterol, LDL / Q000378:metabolism; D017023:Coronary Angiography; D003328:Coronary Thrombosis / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology*; D052279:Creatine Kinase, MB Form / Q000378:metabolism; D004804:Eosinophils / Q000502:physiology*; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D014336:Troponin / Q000378:metabolism; D018487:Ventricular Dysfunction, Left / Q000209:etiology
chemical_list: D008078:Cholesterol, LDL; D014336:Troponin; D052279:Creatine Kinase, MB Form
keywords: coronary artery disease; coronary thrombus; eosinophil; non ST-elevated acute coronary syndromes; white blood cell