title: Preserved endothelial vasomotor function after everolimus-eluting stent implantation.
abstract: OBJECTIVE
  To compare the degree of endothelial dysfunction (ED) in patients treated with everolimus-eluting stent (EES) versus bare metal stent (BMS) implantation.
  
  
  RESULTS
  This is an observational study. A total of 30 elective patients (15 treated with EES and 15 with BMS) were recruited. All patients underwent coronary angiography and intracoronary acetylcholine (Ach) test at different doses at six months after stent implantation. Quantitative coronary angiography analysis was performed to evaluate the changes in mean luminal diameter (MLD) of the segments distal to the distal stent edge after increasing doses of Ach. Both EES and BMS groups had similar baseline characteristics except for stent length (18.6±2.5 vs. 16.5±2.5 mm; p=0.033) and diameter (3.1±0.2 vs. 3.4±0.3 mm; p=0.007). The vasomotion test showed that EES had 3.14% of MLD decrease after Ach infusion and BMS had 2.35% of vasoconstriction (p=0.62). After adjustment for baseline characteristics, no statistical difference was observed between groups.
  
  
  CONCLUSIONS
  In our study EES implantation was associated with a low degree of ED and had a similar vasomotion response as compared to BMS. Prospective randomised investigations are warranted to confirm these findings.
authors.affiliation: Heart Diseases Institute, Bellvitge University Hospital - IDIBELL, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: Gerard
authors.initials: G
authors.lastname: Roura
authors.forename: Sílvia
authors.initials: S
authors.lastname: Homs
authors.forename: José Luis
authors.initials: JL
authors.lastname: Ferreiro
authors.forename: Josep
authors.initials: J
authors.lastname: Gomez-Lara
authors.forename: Rafael
authors.initials: R
authors.lastname: Romaguera
authors.forename: Luís
authors.initials: L
authors.lastname: Teruel
authors.forename: Guillermo
authors.initials: G
authors.lastname: Sánchez-Elvira
authors.forename: Albert
authors.initials: A
authors.lastname: Ariza-Solé
authors.forename: Joan Antoni
authors.initials: JA
authors.lastname: Gómez-Hospital
authors.forename: Ángel
authors.initials: Á
authors.lastname: Cequier
mesh_terms: D000109:Acetylcholine / Q000008:administration & dosage; D000368:Aged; D002317:Cardiovascular Agents / Q000008:administration & dosage*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology*; D004305:Dose-Response Relationship, Drug; D054855:Drug-Eluting Stents; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology*; D000068338:Everolimus / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008670:Metals; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000295:instrumentation*; D011474:Prosthesis Design; D013997:Time Factors; D016896:Treatment Outcome; D014661:Vasoconstriction / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects
chemical_list: D002317:Cardiovascular Agents; D008670:Metals; D000068338:Everolimus; D000109:Acetylcholine