title: Low vaccine efficacy of mumps component among MMR vaccine recipients in Chennai, India.
abstract: Introduction of MMR vaccine was believed to have resulted in a decline in the incidence of measles, mumps and rubella infections. However, recent reports suggest the re-emergence of mumps infection worldwide in the vaccinated populations. It was proposed that the reason for this re-emergence was poor efficacy of MMR vaccine. The present study was aimed to investigate mumps infection in MMR vaccinated and non-vaccinated populations in Chennai, India. Blood samples were collected from acute mumps cases (n=74, 42<12 yr age, 54% males) and investigated for IgM antibody against mumps, IgG antibody against measles, mumps and rubella viruses by ELISA. Sixty seven (91%) patients had received MMR vaccine. All the 67 vaccinated cases were positive for parotitis, and mumps IgM. However, only 10 (15%) were positive for IgG. All samples (100%) were positive for rubella and measles IgG. These findings showed the occurrence of mumps infection among MMR vaccinated individuals in Chennai, India. The MMR vaccine failed to generate anti-mumps IgG. The reason may be low vaccine efficacy of the mumps component of the MMR vaccine used.
authors.forename: Jeevan
authors.initials: J
authors.lastname: Malaiyan
authors.affiliation: Department of Microbiology, Dr ALM PG Institute of Basic Medical Sciences, University of Madras, Chennai, India.
authors.forename: Thangam
authors.initials: T
authors.lastname: Menon
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology / Q000473:pathology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007194:India; D008297:Male; D008457:Measles / Q000453:epidemiology / Q000517:prevention & control; D022542:Measles-Mumps-Rubella Vaccine / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood*; D009107:Mumps / Q000453:epidemiology / Q000517:prevention & control; D012409:Rubella / Q000453:epidemiology / Q000517:prevention & control; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D022542:Measles-Mumps-Rubella Vaccine