title: Noise-induced organized slow fluctuations in networks of neural areas with interarea feed-forward excitation and inhibition.
abstract: Slow coherent spontaneous fluctuations (<0.1 Hz) in functional magnetic resonance imaging blood-oxygen-level-dependent signals have been observed for a resting state of the human brain. In this paper, considering feed-forward inhibition in addition to excitation between brain areas, which we assume to be in up (active) or down (quiescent) states, we propose a model for the generation and organization of the slow fluctuations. Connectivity with feed-forward excitation and inhibition between the areas makes the system have multiple stable states and organized slow fluctuations manifest as noise-induced slow transitions between the states. With various connectivities, we observe slow fluctuations and various organizations, including anticorrelated clusters, through numerical simulations.
authors.affiliation: Center for Neuroscience, Korea Institute of Science and Technology, Seoul 136-791, Republic of Korea.
authors.forename: Dongmyeong
authors.initials: D
authors.lastname: Lee
authors.affiliation: Department of Physics, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea and Asia Pacific Center for Theoretical Physics, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea.
authors.forename: Seunghwan
authors.initials: S
authors.lastname: Kim
authors.affiliation: National Institute for Mathematical Sciences, Daejeon 305-811, Republic of Korea.
authors.forename: Tae-Wook
authors.initials: TW
authors.lastname: Ko
mesh_terms: D001921:Brain / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D003198:Computer Simulation; D006801:Humans; D008279:Magnetic Resonance Imaging; D008959:Models, Neurological; D009433:Neural Inhibition / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D010100:Oxygen / Q000097:blood; D010507:Periodicity; D012146:Rest
chemical_list: D010100:Oxygen