title: Neuronal cell-surface protein neurexin 1 interaction with multi-PDZ domain protein MUPP1.
abstract: Location of membrane proteins is often stabilized by PDZ domain-containing scaffolding proteins. Using the yeast two-hybrid screening, we found that neurexin 1 interacted with multi-PDZ domain protein 1 (MUPP1) through PDZ domain. Neurexin 2 and 3 also interacted with MUPP1. MUPP1 and neurexin 1 were co-localized in cultured cells. These results suggest a novel mechanism for localizing neurexin 1 to synaptic sites.
authors.affiliation: a Department of Biochemistry and u-HARC, College of Medicine , Inje University , Busan , Korea.
authors.forename: Won Hee
authors.initials: WH
authors.lastname: Jang
authors.forename: Sun Hee
authors.initials: SH
authors.lastname: Choi
authors.forename: Joo Young
authors.initials: JY
authors.lastname: Jeong
authors.forename: Jung-Hwa
authors.initials: JH
authors.lastname: Park
authors.forename: Sang-Jin
authors.initials: SJ
authors.lastname: Kim
authors.forename: Dae-Hyun
authors.initials: DH
authors.lastname: Seog
mesh_terms: D000818:Animals; D002135:Calcium-Binding Proteins; D002352:Carrier Proteins / Q000737:chemistry* / Q000378:metabolism*; D008565:Membrane Proteins; D051379:Mice; D019006:Neural Cell Adhesion Molecules / Q000378:metabolism*; D009474:Neurons / Q000166:cytology* / Q000378:metabolism*; D054731:PDZ Domains; D011485:Protein Binding; D021381:Protein Transport
chemical_list: D002135:Calcium-Binding Proteins; D002352:Carrier Proteins; D008565:Membrane Proteins; C491750:Mpdz protein, mouse; D019006:Neural Cell Adhesion Molecules; C527193:Nrxn1 protein, mouse
keywords: PDZ domain; multi-PDZ domain protein 1 (MUPP1); neurexin; protein–protein interaction