title: Relationship between spectral-domain optical coherence tomography and standard automated perimetry in healthy and glaucoma patients.
abstract: OBJECTIVE
  To evaluate the relationship between spectral-domain optical coherence tomography (OCT) and standard automated perimetry (SAP) in healthy and glaucoma individuals.
  
  
  METHODS
  The sample comprised 338 individuals divided into 2 groups according to intraocular pressure and visual field outcomes. All participants underwent a reliable SAP and imaging of the optic nerve head with the Cirrus OCT. Pearson correlations were calculated between threshold sensitivity values of SAP (converted to linear scale) and OCT parameters.
  
  
  RESULTS
  Mean age did not differ between the control and glaucoma groups (59.55 ± 9.7 years and 61.05 ± 9.4 years, resp.; P = 0.15). Significant differences were found for the threshold sensitivities at each of the 52 points evaluated with SAP (P < 0.001) and the peripapillary retinal nerve fiber layer (RNFL) thicknesses, except at 3 and 9 clock-hour positions between both groups. Mild to moderate correlations (ranging between 0.286 and 0.593; P < 0.001) were observed between SAP and most OCT parameters in the glaucoma group. The strongest correlations were found between the inferior RNFL thickness and the superior hemifield points. The healthy group showed lower and weaker correlations than the glaucoma group.
  
  
  CONCLUSIONS
  Peripapillary RNFL thickness measured with Cirrus OCT showed mild to moderate correlations with SAP in glaucoma patients.
authors.affiliation: Ophthalmology Department, Miguel Servet University Hospital, Aragon Health Sciences Institute, Isabel la Catolica 1-3, 50009 Zaragoza, Spain.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Abadia
authors.affiliation: Ophthalmology Department, Miguel Servet University Hospital, Aragon Health Sciences Institute, Isabel la Catolica 1-3, 50009 Zaragoza, Spain ; Department of Surgery, Gynecology and Obstetrics, University of Zaragoza, 50009 Zaragoza, Spain.
authors.forename: Antonio
authors.identifier: 0000-0002-2914-2593
authors.initials: A
authors.lastname: Ferreras
authors.affiliation: Ophthalmology Department, Miguel Servet University Hospital, Aragon Health Sciences Institute, Isabel la Catolica 1-3, 50009 Zaragoza, Spain ; Department of Surgery, Gynecology and Obstetrics, University of Zaragoza, 50009 Zaragoza, Spain.
authors.forename: Pilar
authors.identifier: 0000-0002-6202-2382
authors.initials: P
authors.lastname: Calvo
authors.affiliation: Ophthalmology Department, Miguel Servet University Hospital, Aragon Health Sciences Institute, Isabel la Catolica 1-3, 50009 Zaragoza, Spain.
authors.forename: Mirian
authors.initials: M
authors.lastname: Ara
authors.affiliation: Ophthalmology Department, Miguel Servet University Hospital, Aragon Health Sciences Institute, Isabel la Catolica 1-3, 50009 Zaragoza, Spain.
authors.forename: Blanca
authors.initials: B
authors.lastname: Ferrandez
authors.affiliation: Ophthalmology Department, Miguel Servet University Hospital, Aragon Health Sciences Institute, Isabel la Catolica 1-3, 50009 Zaragoza, Spain.
authors.forename: Sofia
authors.initials: S
authors.lastname: Otin
authors.affiliation: Department of Ophthalmology, University of Siena, 53100 Siena, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Frezzotti
authors.affiliation: Ophthalmology Department, Miguel Servet University Hospital, Aragon Health Sciences Institute, Isabel la Catolica 1-3, 50009 Zaragoza, Spain ; Department of Surgery, Gynecology and Obstetrics, University of Zaragoza, 50009 Zaragoza, Spain.
authors.forename: Luis E
authors.initials: LE
authors.lastname: Pablo
authors.affiliation: Department of Neurosciences, University of Pisa, 56126 Pisa, Italy.
authors.forename: Michele
authors.identifier: 0000-0003-3211-3344
authors.initials: M
authors.lastname: Figus
mesh_terms: D000368:Aged; D005260:Female; D005901:Glaucoma / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000379:methods*