title: Osteonecrosis of the jaw in patients treated with oral and intravenous bisphosphonates: experience in Sweden.
abstract: OBJECTIVE
  To describe the prevalence, inciting factors, and treatment outcomes of bisphosphonate-related osteonecrosis of the jaw (BRONJ) during the 2003-2010 period in southern Sweden (population, approximately 1.2 million people).
  
  
  METHODS
  Patient records were searched for inflammatory conditions including unspecified inflammation, osteomyelitis, osteonecrosis due to drugs, and other osteonecrosis. Data on underlying disease, type of bisphosphonate (BP), inciting factor, location, stage, treatment, and treatment outcomes were collected.
  
  
  RESULTS
  Of the 341 patients identified, 55 had been diagnosed with BRONJ. Those with a malignant disease were treated with intravenous BPs, and those with osteoporosis were treated with oral BPs. All but 5 were treated with antibiotics and 47 with local resection. Healing was recorded in 79% of patients with osteoporosis and in 26% of patients with malignant disease.
  
  
  CONCLUSIONS
  Healing in patients with osteoporosis occurred more frequently than in patients with a malignant disease treated with intravenous BPs (P = .00009).
authors.affiliation: Senior resident, Department of Oral and Maxillofacial Surgery and Oral Medicine, Faculty of Odontology, Malmö University, Department of Oral and Maxillofacial Surgery, Skåne University Hospital, Lund, Sweden. Electronic address: fredrik.hallmer@mah.se.
authors.forename: Fredrik
authors.initials: F
authors.lastname: Hallmer
authors.affiliation: Professor and Chairman, Department of Oral Surgery and Oral Medicine, Faculty of Odontology, University of Oslo, Oslo, Norway.
authors.forename: Tore
authors.initials: T
authors.lastname: Bjørnland
authors.affiliation: General Dentist, Private Practice, Trelleborg, Sweden.
authors.forename: Anders
authors.initials: A
authors.lastname: Nicklasson
authors.affiliation: Associate Professor and Head, Department of Oral and Maxillofacial Surgery and Oral Medicine, Faculty of Odontology, Malmö University, Malmö, Sweden.
authors.forename: Jonas P
authors.initials: JP
authors.lastname: Becktor
authors.affiliation: Associate Professor, Department of Oral and Maxillofacial Surgery and Oral Medicine, Faculty of Odontology, Malmö University, Malmö, Sweden.
authors.forename: Gunilla
authors.initials: G
authors.lastname: Andersson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000453:epidemiology* / Q000628:therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D013548:Sweden / Q000453:epidemiology; D016896:Treatment Outcome