title: Recurrent hypoglycemia triggered by sorafenib therapy in a patient with hemangiopericytoma.
abstract: Targeted therapy has been proven to be one of the most effective cancer treatments. However, some endocrine disorders can occur during treatment with targeted agents. We report the case of a patient who exhibited a wax and wane pattern of hypoglycemia that was attributed to sorafenib therapy. A 32-year-old woman with metastatic hemangiopericytoma visited the emergency department in a stuporous state. Nonhyperinsulinemic hypoglycemia was diagnosed, was exacerbated shortly after sorafenib therapy, and was improved by the cessation of sorafenib with additional glucocorticoid therapy. Patients with metastatic hemangiopericytoma should be carefully monitored with particular attention to hypoglycemia when sorafenib therapy is initiated.
authors.affiliation: Department of Internal Medicine, National Cancer Center, Goyang, Korea.
authors.forename: Si Won
authors.initials: SW
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, National Cancer Center, Goyang, Korea.
authors.forename: Eun Kyung
authors.initials: EK
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, National Cancer Center, Goyang, Korea.
authors.forename: Tak
authors.initials: T
authors.lastname: Yun
authors.affiliation: Department of Internal Medicine, National Cancer Center, Goyang, Korea.
authors.forename: Young-Woong
authors.initials: YW
authors.lastname: Won
authors.affiliation: Department of Internal Medicine, National Cancer Center, Goyang, Korea.
authors.forename: Eun Jeong
authors.initials: EJ
authors.lastname: Ko
authors.affiliation: Department of Internal Medicine, National Cancer Center, Goyang, Korea.
authors.forename: Mihong
authors.initials: M
authors.lastname: Choi
authors.affiliation: Department of Internal Medicine, National Cancer Center, Goyang, Korea.
authors.forename: Sang Il
authors.initials: SI
authors.lastname: Choi
authors.affiliation: Department of Internal Medicine, National Cancer Center, Goyang, Korea.
authors.forename: Sun Seob
authors.initials: SS
authors.lastname: Park
authors.affiliation: Department of Pathology, National Cancer Center, Goyang, Korea.
authors.forename: Eun Kyung
authors.initials: EK
authors.lastname: Hong
keywords: Hemangiopericytoma; Hypoglycemia; Sorafenib