title: Polihexanide solution is more efficient than alcohol to remove phenol in chemical matricectomy: an in vitro study.
abstract: For treatment of ingrown toenails, a phenolization approach is often chosen. Many reports describe a lavage of the wound with alcohol to neutralize any residual phenol; however, it remains uncertain if there is a more effective solution for use in the lavage step. The aim of our study was to analyze the suitability and effectiveness of 0.1% polihexanide solution compared with isopropyl alcohol in the removal of excess phenol after treatment for ingrown toenails. We performed an in vitro study using human matrix and a diffusion cell apparatus to measure the amount of phenol remaining after two lavage washes. The effect of phenol evaporation was also examined.When phenol was irrigated with alcohol alone, 27.43 ± 4.10 mg (57.74%) of the initial amount of phenol was recovered. If irrigated with 0.1% polihexanide, 35.98 ± 2.93 mg (75.74%) of phenol was recovered. These results indicate that a polihexanide lavage step has significantly higher efficiency for removing excess phenol relative to alcohol.
authors.affiliation: Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain.
authors.forename: Damian
authors.initials: D
authors.lastname: Cordoba Diaz
authors.forename: Ricardo
authors.initials: R
authors.lastname: Becerro de Bengoa Vallejo
authors.forename: Marta Elena
authors.initials: ME
authors.lastname: Losa Iglesias
authors.forename: Manuel
authors.initials: M
authors.lastname: Cordoba Diaz
mesh_terms: D019840:2-Propanol / Q000737:chemistry* / Q000627:therapeutic use; D001645:Biguanides / Q000737:chemistry* / Q000627:therapeutic use; D002425:Cautery / Q000379:methods*; D006801:Humans; D066298:In Vitro Techniques; D009262:Nails / Q000737:chemistry*; D009263:Nails, Ingrown / Q000175:diagnosis / Q000628:therapy*; D019800:Phenol / Q000737:chemistry* / Q000627:therapeutic use; D012995:Solubility; D012997:Solvents / Q000737:chemistry* / Q000627:therapeutic use; D007507:Therapeutic Irrigation / Q000379:methods*
chemical_list: D001645:Biguanides; D012997:Solvents; C031233:polihexanide; D019800:Phenol; D019840:2-Propanol
keywords: alcohol; ingrown toenail; phenol; polihexanide