title: Preorganized aryltriazole foldamers as effective transmembrane transporters for chloride anion.
abstract: Preorganized aryltriazole foldamers 1 and 2 were designed and synthesized. NMR studies and X-ray analysis demonstrate that 1 adopts a crescent conformation driven by a series of continuous hydrogen bonds at the periphery of the foldamer, whereas 2 displays a coil conformation. NMR titrations reveal that the affinities of fully preorganized foldamer 1 for halogen anions are much stronger that those of partially preorganized foldamer 2. Furthermore, it is found that such full preorganization makes 1 an effective transmembrane transporter for the chloride anion across a lipid bilayer.
authors.affiliation: College of Chemistry, Beijing Normal University , Beijing 100875, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Shang
authors.forename: Wen
authors.initials: W
authors.lastname: Si
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
authors.forename: Yanke
authors.initials: Y
authors.lastname: Che
authors.forename: Jun-Li
authors.initials: JL
authors.lastname: Hou
authors.forename: Hua
authors.initials: H
authors.lastname: Jiang
mesh_terms: D000838:Anions / Q000737:chemistry; D002712:Chlorides / Q000737:chemistry*; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D008051:Lipid Bilayers / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D014230:Triazoles / Q000737:chemistry*
chemical_list: D000838:Anions; D002712:Chlorides; D008051:Lipid Bilayers; D014230:Triazoles