title: Differential background clearance of fluorodeoxyglucose activity in normal tissues and its clinical significance.
abstract: The clearance of 2-deoxy-2-[18F]fluoro-D-glucose (FDG) activity in normal tissues varies significantly with extended distribution time. Although most tissues have lower standardized uptake value (SUV) on 2-hour/3-hour delayed images, others may have stable or higher FDG activity with longer distribution times. The continuously decreased SUV on delayed imaging in some tissues, especially in the liver, indicates that longer distribution time will decrease background activity, increase lesion-to-background ratio, and thus improve imaging quality, whereas the continuously increased SUV from 1 to 3 hours in the heart suggest that longer distribution time will improve detection of viable myocardium in a viability study.
authors.affiliation: Department of Radiology, Philadelphia VA Medical Center, 3900 Woodland Avenue, Philadelphia, PA 19104, USA; Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA. Electronic address: gangcheng99@yahoo.com.
authors.forename: Gang
authors.initials: G
authors.lastname: Cheng
authors.affiliation: Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.
authors.forename: Abass
authors.initials: A
authors.lastname: Alavi
authors.affiliation: Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.
authors.forename: Nam Ju
authors.initials: NJ
authors.lastname: Lee
authors.affiliation: Department of Radiology, Philadelphia VA Medical Center, 3900 Woodland Avenue, Philadelphia, PA 19104, USA.
authors.forename: Scott R
authors.initials: SR
authors.lastname: Akers
mesh_terms: D000284:Administration, Oral; D003287:Contrast Media / Q000008:administration & dosage; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography / Q000379:methods*; D011446:Prospective Studies; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D013997:Time Factors; D014018:Tissue Distribution; D051598:Whole Body Imaging / Q000379:methods
chemical_list: D003287:Contrast Media; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: Background activity; Delayed imaging; Distribution time; Fluorodeoxyglucose; PET; SUV