title: Dock-family exchange factors in cell migration and disease.
abstract: Dock family proteins are evolutionary conserved exchange factors for the Rho GTPases Rac and Cdc42. There are 11 Dock proteins in mammals, named Dock1 (or Dock180) to Dock11 that play different cellular functions. In particular, Dock proteins regulate actin cytoskeleton, cell adhesion and migration. Not surprisingly, members of the Dock family have been involved in various pathologies, including cancer and defects in the central nervous and immune systems. This review proposes an update of the recent findings regarding the function of Dock proteins, focusing on their role in the control of cell migration and invasion and the consequences in human diseases.
authors.affiliation: CNRS UMR 5237, Centre de Recherche de Biochimie Macromoléculaire, France; Montpellier University, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Gadea
authors.affiliation: CNRS UMR 5237, Centre de Recherche de Biochimie Macromoléculaire, France; Montpellier University, France. Electronic address: anne.blangy@crbm.cnrs.fr.
authors.forename: Anne
authors.initials: A
authors.lastname: Blangy
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism; D000818:Animals; D001369:Axons / Q000378:metabolism; D001862:Bone Resorption / Q000378:metabolism; D002448:Cell Adhesion; D002465:Cell Movement; D020662:Guanine Nucleotide Exchange Factors / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007107:Immune System / Q000502:physiology; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000473:pathology; D010010:Osteoclasts / Q000378:metabolism; D015398:Signal Transduction; D020764:cdc42 GTP-Binding Protein / Q000378:metabolism; D020741:rho GTP-Binding Proteins / Q000378:metabolism
chemical_list: D020662:Guanine Nucleotide Exchange Factors; D020764:cdc42 GTP-Binding Protein; D020741:rho GTP-Binding Proteins
keywords: Adhesion; Amoeboid; Cancer; Cdc42; DHR2; Dock1; Dock10; Dock11; Dock180; Dock2; Dock3; Dock4; Dock5; Dock6; Dock7; Dock8; Dock9; Exchange factor; GPCR; Integrin; Migration; Osteoclast; Rac1; Rho GTPase; Synapse; Zizimin