title: Formulation and bioequivalence of two Valsartan/Amlodipine immediate release tablets after a single oral administration.
abstract: The aim of this study was to formulate a film-coated Valsartan/Amlodipine (VS/AM) immediate release tablets and to evaluate their in vivo release profile. VS/AM core tablets were manufactured using dry granulation method. Opadry aqueous coating dispersion was used as film coating material. Dissolution of the film coated tablets was tested in 900 ml of 0.5% SLS media, bioequivalence of tablets was tested by comparisons against the reference brand product. The ICH guidelines were used to evaluate the stability of the obtained tablets. The coated tablets were subjected to gastric pH, and drug release was analyzed using HPLC system to evaluate the efficiency of the film coat. The coated tablets had no defects. VS/AM release met the FDA guidelines for bioequivalence studies. Statistical comparison of the main pharmacokinetic parameters showed no significant difference between test and reference. These findings suggest that aqueous film coating with Opadry system is an easy and economical approach for preparing stable film coated VS/AM tablets without compromising their in vivo drugs release.
authors.affiliation: Pharmaceutics & Pharmacokinetics Units, Department of Pharmacy, Faculty of Medicine & Health Sciences, An-Najah National University, P.O. Box 7. Nablus, Palestine.
authors.forename: Abdel Naser
authors.initials: AN
authors.lastname: Zaid
authors.affiliation: Pharmacare Ltd. Beitunia- P.O. Box 677. Ramallah, Palestine.
authors.forename: Salam
authors.initials: S
authors.lastname: Natur
authors.affiliation: Pharmacare Ltd. Beitunia- P.O. Box 677. Ramallah, Palestine.
authors.forename: Aiman
authors.initials: A
authors.lastname: Qaddomi
authors.affiliation: Pharmaceutics & Pharmacokinetics Units, Department of Pharmacy, Faculty of Medicine & Health Sciences, An-Najah National University, P.O. Box 7. Nablus, Palestine.
authors.forename: Murad
authors.initials: M
authors.lastname: Abualhasan
authors.affiliation: Pharmaceutics & Pharmacokinetics Units, Department of Pharmacy, Faculty of Medicine & Health Sciences, An-Najah National University, P.O. Box 7. Nablus, Palestine.
authors.forename: Rowa
authors.initials: R
authors.lastname: Al-Ramahi
authors.affiliation: Pharmaceutics & Pharmacokinetics Units, Department of Pharmacy, Faculty of Medicine & Health Sciences, An-Najah National University, P.O. Box 7. Nablus, Palestine.
authors.forename: Naser
authors.initials: N
authors.lastname: Shraim
authors.affiliation: Pharmaceutics & Pharmacokinetics Units, Department of Pharmacy, Faculty of Medicine & Health Sciences, An-Najah National University, P.O. Box 7. Nablus, Palestine.
authors.forename: Saed
authors.initials: S
authors.lastname: Khammash
authors.affiliation: Pharmaceutics & Pharmacokinetics Units, Department of Pharmacy, Faculty of Medicine & Health Sciences, An-Najah National University, P.O. Box 7. Nablus, Palestine.
authors.forename: Nidal
authors.initials: N
authors.lastname: Jaradat
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D017311:Amlodipine / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D000068838:Amlodipine, Valsartan Drug Combination; D002626:Chemistry, Pharmaceutical; D018592:Cross-Over Studies; D004338:Drug Combinations; D006801:Humans; D007004:Hypoglycemic Agents / Q000493:pharmacokinetics*; D012995:Solubility; D013607:Tablets; D013777:Tetrazoles / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D013810:Therapeutic Equivalency
chemical_list: D000068838:Amlodipine, Valsartan Drug Combination; D004338:Drug Combinations; D007004:Hypoglycemic Agents; D013607:Tablets; D013777:Tetrazoles; D017311:Amlodipine