title: ZnO nanowire arrays exhibit cytotoxic distinction to cancer cells with different surface charge density: cytotoxicity is charge-dependent.
abstract: Using distinct ZnO NW arrays to provide positively charged surface, charge effect on cytotoxicity is investigated. 1-D structure of ZnO NWs is the main factor leads to apoptosis accompanied by ROS enrichment and GSH depletion, and electrostatic interaction between positively charged ZnO NWs and negatively charged cells make important contribution to the degree of ZnO NW arrays damaging cell membrane.
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing Key Laboratory of Electrochemical Process and Technology for Materials, Beijing University of Chemical Technology, Beijing, 100029, P. R. China; Department of Chemistry, Beijing Key Laboratory of Microanalytical Methods and Instrumentation, Tsinghua University, Beijing, 100084, P. R. China.
authors.forename: Ruizhi
authors.initials: R
authors.lastname: Ning
authors.forename: Shiqi
authors.initials: S
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Wu
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.forename: Jin-Ming
authors.initials: JM
authors.lastname: Lin
mesh_terms: D004354:Drug Screening Assays, Antitumor; D006801:Humans; D061986:MCF-7 Cells; D008855:Microscopy, Electron, Scanning; D053770:Nanowires; D009369:Neoplasms / Q000473:pathology*; D013499:Surface Properties; D015034:Zinc Oxide / Q000737:chemistry*
chemical_list: D015034:Zinc Oxide
keywords: apoptosis; charge effect; cytotoxicity; nanowire arrays