title: Hypersensitivity reactions to nonsteroidal anti-inflammatory drugs.
abstract: Nonsteroidal anti-inflammatory drugs (NSAIDs) are the drugs most commonly involved in hypersensitivity drug reactions. Such reactions can be due to the release of inflammatory mediators in the absence of specific immunologic recognition, or immunoglobulin E (IgE)- or T-cell-selective responses. The former include upper and lower airway symptoms in patients with chronic underlying respiratory disease, the exacerbation of chronic spontaneous urticaria, and the induction of cutaneous symptoms. The latter include selective responses to a single NSAID with good tolerance to strong cyclooxygenase-1 inhibitors, with a putative IgE or T-cell mechanism proposed. These reactions can be acute or delayed.
authors.affiliation: Allergy Unit, University Hospital-IBIMA, Malaga 29008, Spain.
authors.forename: Maria Jose
authors.initials: MJ
authors.lastname: Torres
authors.affiliation: Allergy Unit, University Hospital-IBIMA, Malaga 29008, Spain.
authors.forename: Esther
authors.initials: E
authors.lastname: Barrionuevo
authors.affiliation: Department of Immunology Rheumatology and Allergy, Medical University of Lodz, Lodz, Poland; Department of Immunology, Rheumatology & Allergy, Chair of Clinical Immunology and Microbiology, Medical University of Lodz, 251 Pomorska Street Blg 5, Lodz 92213, Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Kowalski
authors.affiliation: Allergy Unit, University Hospital-IBIMA, Malaga 29008, Spain. Electronic address: mblancago@gmail.com.
authors.forename: Miguel
authors.initials: M
authors.lastname: Blanca
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000145:classification; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology / Q000628:therapy*; D006801:Humans
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal
keywords: Allergic; Clinical diagnosis; Hypersensitivity; Management; Nonallergic; Nonsteroidal anti-inflammatory drugs