title: Advances in pediatric celiac disease.
abstract: OBJECTIVE
  To summarize the recent advances in celiac disease in children.
  
  
  RESULTS
  New clues to the pathogenesis of celiac disease continue to emerge that may implicate the role of microbiome changes, antirotavirus VP7 antibodies, and the Parkinson's disease seven gene in celiac disease. Updated guidelines in pediatrics no longer support biopsies in all patients with celiac disease who have been identified by serology, clinical signs, and genetics. Serology screening of total immunoglobulin A in all patients may not be necessary in select patients. Prevalence and additional diseases associated with celiac disease continue to be elucidated.
  
  
  CONCLUSIONS
  Our knowledge of celiac disease continues to grow with increasing evidence of the pathogenesis, genetics, diagnosis, and risk factors of the disease. Major changes have been made with respect to the guidelines for pediatric celiac disease, and potential improvements to simplify the algorithms for diagnosis and elimination of unessential testing have been proposed by new studies.
authors.affiliation: aCollege of Pharmacy and Health Sciences, St. John's University bNewYork Presbyterian Hospital/Columbia University Medical Center, New York City, NY, USA.
authors.forename: Tran H
authors.initials: TH
authors.lastname: Tran
mesh_terms: D000293:Adolescent; D002446:Celiac Disease / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics / Q000276:immunology; D002648:Child; D055050:Diet, Gluten-Free; D042241:Early Diagnosis; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000097:blood* / Q000235:genetics; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood* / Q000276:immunology; D007223:Infant; D017410:Practice Guidelines as Topic; D015995:Prevalence; D012307:Risk Factors
chemical_list: D006680:HLA Antigens; D007070:Immunoglobulin A