title: [Vegetative state treated with acupoint injection combined with plum-blossom needle in children: a randomized controlled trial].
abstract: OBJECTIVE
  To observe the clinical efficacy difference on vegetative state in children between acupoint injection combined with plum-blossom needle and western medication based on basic treatment.
  
  
  METHODS
  Forty-eight children of vegetative state were randomized into an observation group and a control group, 24 cases in each one. On the basis of the treatment of transcranial magnetic stimulation apparatus, balancing treatment apparatus and massage, the acupoint injection and tapping method with plum-blossom needle were adopted in the observation group, in which Xingnaojing injection, mouse nerve growth factor (mNGF) injection, monosialotetrahexosylganglioside sodium injection (MSI), compound Danshen injection were divided in 6 pairs and were injected respectively in Baihui (GV 20), Yongquan (KI 1), Fengfu (GV 16), Yamen (GV 15) and the others, 0.5 mL in each acupoint, once a day for continuous 10 days. Additionally, the tapping method with plum-blossom needle was used on the Governor Vessel and Jiaji (EX-B 2) on the back. In the control group, the intravenous infusion was adopted with citicoline sodium injection, mannitol injection and dexamethasone injection. The treatment was given once a day, 20 days of treatment made one session and totally 3 sessions were required in the two groups. The clinical efficacy, the vegetative state score and the mean curing time were observed after 20 days, 40 days and 60 days of treatment between the two groups.
  
  
  RESULTS
  The effective rates were 58.3% (14/24), 70.8% (17/24) and 79.2% (19/24) in 20 days, 40 days and 60 days of treatment in the observation group and 20.8% (5/24), 45.8% (11/24) and 58.3% (14/24) in the control group respectively. The efficacy in the observation group was superior to those in the control group (P < 0.01, P < 0.05). The vegetative state score was improved apparently after 20 days, 40 days and 60 days of treatment as compared with those before treatment separately (all P < 0.05). It was improved obviously at the each time point after treatment in the observation group as compared with that in the control group (3.34 +/- 2.41 vs 2.64 +/- 11.56, 6.20 +/- 1.46 vs 4.34 +/- 1.64, 11.26 +/- 2.63 vs 8.75 +/- 2.18, all P < 0.05). The mean curing time was (45.67 +/- 16.24) days in the observation group, which was shorter apparently than that of (55.34 +/- 4.57) days in the control group (P < 0.05).
  
  
  CONCLUSIONS
  Based on basic treatment acupoint injection combined with tapping method of plum-blossom needle achieve the reliable efficacy on vegetative state in children.
authors.forename: Ying
authors.initials: Y
authors.lastname: Tang
authors.forename: Qing
authors.initials: Q
authors.lastname: Shang
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Zhou
mesh_terms: D015669:Acupuncture Points; D015670:Acupuncture Therapy / Q000295:instrumentation; D000818:Animals; D002675:Child, Preschool; D003131:Combined Modality Therapy; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D051379:Mice; D020932:Nerve Growth Factor / Q000008:administration & dosage*; D018458:Persistent Vegetative State / Q000188:drug therapy / Q000628:therapy*; D010618:Phenanthrolines / Q000008:administration & dosage*; D027561:Salvia miltiorrhiza; D016896:Treatment Outcome
chemical_list: D004365:Drugs, Chinese Herbal; D010618:Phenanthrolines; C028972:dan-shen root extract; D020932:Nerve Growth Factor