title: Concentrations of blood folate in Brazilian studies prior to and after fortification of wheat and cornmeal (maize flour) with folic acid: a review.
abstract: BACKGROUND
  In July 2004, the Brazilian Ministry of Health through the National Health Surveillance Agency made the fortification of wheat flour and cornmeal (maize flour) with iron and folic acid mandatory, with the intention of reducing the rate of diseases such as neural tube defects.
  
  
  OBJECTIVE
  The aim of the study was to investigate the impact of the folic acid fortified wheat flour and cornmeal on serum and red blood cell folate levels and on the reduction of neural tube defects in different Brazilian studies.
  
  
  METHODS
  In order to compare folate concentrations in the Brazilian population prior to and following the implementation of mandatory fortification of wheat and cornmeal, studies that involved blood draws between January 1997 and May 2004 (pre-fortification period), and from June 2004 to the present (post-fortification period) were chosen. The data search included PubMed and Scopus databases as well as the Brazilian Digital Library of Theses and Dissertations. The following keywords were employed for the query: folate, folic acid, fortification, Brazil, healthy population, the elderly, children and pregnant women.
  
  
  RESULTS
  A total of 47 Brazilian studies were selected; 26 from the pre-fortification period and 22 after the fortification implementation. The studies were classified according to the cohort investigated (pregnant women, children, adolescents, adults and the elderly). After the implementation of flour fortification with folic acid in Brazil, serum folate concentrations increased in healthy populations (57% in children and adolescents and 174% in adults), and the incidence of neural tube defects dropped.
  
  
  CONCLUSIONS
  Folic acid fortification of wheat flour and cornmeal increased the blood folate concentrations and reduced the incidence of neural tube defects.
authors.affiliation: Faculdade de Ciências Farmacêuticas da Universidade de São Paulo (FCF-USP), São Paulo, SP, Brazil.
authors.forename: Jéssica Carrilho
authors.initials: JC
authors.lastname: Britto
authors.affiliation: Faculdade de Ciências Médicas da Santa Casa de São Paulo (FCMSCSP), São Paulo, SP, Brazil.
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Cançado
authors.affiliation: Faculdade de Ciências Farmacêuticas da Universidade de São Paulo (FCF-USP), São Paulo, SP, Brazil.
authors.forename: Elvira Maria
authors.initials: EM
authors.lastname: Guerra-Shinohara
keywords: Adult; Blood; Brazil; Folic acid; Food; fortification