title: Helicobacter pylori infection and stem cells at the origin of gastric cancer.
abstract: Helicobacter pylori infection is now recognized as the main and specific infectious cause of cancer in the world. It is responsible for gastric adenocarcinomas of both intestinal and diffuse types, which are the long-term consequences of the chronic infection of the gastric mucosa. Case-control studies have shown an association between the two, recognized as early as 1994 and further substantiated by interventional studies in which H. pylori eradication has led to the prevention of at least part of the gastric cancers. Experimental studies have highlighted the role of bone marrow-derived cells (BMDCs) and particularly mesenchymal stem cells, in the neoplastic process in about a quarter of the cases and possibly an epithelial-mesenchymal transition (EMT) in the other cases. Different studies have confirmed that chronic infection with H. pylori induces a chronic inflammation and subsequent damage of the gastric epithelial mucosa, leading to BMDC recruitment. Once recruited, these cells home and differentiate by cell-cell fusion with local gastric epithelial cells, bearing local stem cell failure and participating in tissue regeneration. The context of chronic infection and inflammation leads to an EMT and altered tissue regeneration and differentiation from both local epithelial stem cells and BMDC. EMT induces the emergence of CD44+ cells possessing mesenchymal and stem cell properties, resulting in metaplastic and dysplastic lesions to give rise, after additional epigenetic and mutational events, to the emergence of cancer stem cells (CSCs) and adenocarcinoma.
authors.affiliation: 1] Laboratoire de Bactériologie, University of Bordeaux, Bordeaux, France [2] INSERM U853, Bordeaux, France.
authors.forename: E
authors.initials: E
authors.lastname: Bessède
authors.affiliation: 1] Laboratoire d'Histologie, University of Bordeaux, Bordeaux, France [2] EA2406 Histologie et pathologie moléculaire des tumeurs, University of Bordeaux, Bordeaux, France.
authors.forename: P
authors.initials: P
authors.lastname: Dubus
authors.affiliation: 1] Laboratoire de Bactériologie, University of Bordeaux, Bordeaux, France [2] INSERM U853, Bordeaux, France.
authors.forename: F
authors.initials: F
authors.lastname: Mégraud
authors.affiliation: 1] Laboratoire de Bactériologie, University of Bordeaux, Bordeaux, France [2] INSERM U853, Bordeaux, France.
authors.forename: C
authors.initials: C
authors.lastname: Varon
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000378:metabolism* / Q000473:pathology; D002908:Chronic Disease; D058750:Epithelial-Mesenchymal Transition; D016481:Helicobacter Infections / Q000378:metabolism* / Q000473:pathology; D016480:Helicobacter pylori / Q000378:metabolism*; D006801:Humans; D007249:Inflammation; D059630:Mesenchymal Stem Cells / Q000378:metabolism* / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000378:metabolism* / Q000473:pathology; D013274:Stomach Neoplasms / Q000209:etiology / Q000378:metabolism* / Q000473:pathology