title: Easily accessible auxiliary for palladium-catalyzed intramolecular amination of C(sp²)-H and C(sp³)-H bonds at δ- and ε-positions.
abstract: An easily synthesized and accessible N,O-bidentate auxiliary has been developed for selective C-H activation under palladium catalysis. The novel auxiliary showed its first powerful application in C-H functionalization of remote positions. Both C(sp(2))-H and C(sp(3))-H bonds at δ- and ε-positions were effectively activated, thus giving tetrahydroquinolines, benzomorpholines, pyrrolidines, and indolines in moderate to excellent yields by palladium-catalyzed intramolecular C-H amination.
authors.affiliation: Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry, Chemical Engineering and Materials Science Soochow University, Suzhou 215123 (P.R. China).
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.forename: Changpeng
authors.initials: C
authors.lastname: Chen
authors.forename: Jingyu
authors.initials: J
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: Han
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.forename: Kun
authors.initials: K
authors.lastname: Guo
authors.forename: Pei
authors.initials: P
authors.lastname: Liu
authors.forename: Mingyu
authors.initials: M
authors.lastname: Guan
authors.forename: Yingming
authors.initials: Y
authors.lastname: Yao
authors.forename: Yingsheng
authors.initials: Y
authors.lastname: Zhao
keywords: CH activation; amination; cyclization; heterocycles; palladium