title: Longitudinal changes of trabecular bone score after estrogen deprivation: effect of menopause and aromatase inhibition.
abstract: OBJECTIVE
  To examine the effects of the menopausal transition and treatment with aromatase inhibitors (AI) on trabecular bone score (TBS, a newly proposed index of bone architecture derived from DXA vertebral scans) and vertebral bone mineral density (BMD).
  
  
  METHODS
  Retrospective cohort study on 29 women who became postmenopausal during a mean follow-up of 2.9 years (MP group) and 34 women treated with AI during a mean follow-up of 2.1 years (AI group). BMD was measured by DXA and TBS with a specific software.
  
  
  RESULTS
  TBS decreased after menopause, but the change was significantly lower than that of the lumbar BMD (-4.6 vs. -6.8 %; mean difference: 2.2 %; p = 0.016). An even larger difference was observed in the AI group (-2.1 vs. -5.9 %; mean difference: 3.8 %; p = 0.002).
  
  
  CONCLUSIONS
  The decrease of TBS induced by menopause or treatment with AI is significantly lower than that of lumbar BMD.
authors.affiliation: Department of Clinical and Experimental Medicine, University of Parma, Via Gramsci, 14, 43126, Parma, Italy, mario.pedrazzoni@unipr.it.
authors.forename: M
authors.initials: M
authors.lastname: Pedrazzoni
authors.forename: A
authors.initials: A
authors.lastname: Casola
authors.forename: I
authors.initials: I
authors.lastname: Verzicco
authors.forename: B
authors.initials: B
authors.lastname: Abbate
authors.forename: R
authors.initials: R
authors.lastname: Vescovini
authors.forename: P
authors.initials: P
authors.lastname: Sansoni
mesh_terms: D015502:Absorptiometry, Photon; D047072:Aromatase Inhibitors / Q000009:adverse effects*; D015519:Bone Density / Q000187:drug effects / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008593:Menopause / Q000187:drug effects / Q000502:physiology*; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000000981:diagnostic imaging*; D012189:Retrospective Studies; D013131:Spine / Q000000981:diagnostic imaging
chemical_list: D047072:Aromatase Inhibitors