title: "On water" expedient synthesis of 3-indolyl-3-hydroxy oxindole derivatives and their anticancer activity in vitro.
abstract: A series of 3-indolyl-3-hydroxy oxindole derivatives (n = 41) were synthesized by the green aminocatalytic method with excellent yields under mild reaction conditions. All the newly synthesized derivatives were subjected to evaluate their cytotoxic properties against different human cancer cell lines. Results indicated that about 73% of the derivatives exhibited significant anti-proliferative activities against leukemia (U937, THP-1), lung (A549) and breast cancer (MCF7) cell lines. Among them a few of the derivatives exhibited the most potent and effective cytotoxic activities on U937 (34, 36, 38 and 41) and MCF7 (12, 35, 40 and 41) cell lines, and their anti-proliferation activities are better than the positive control, Etoposide.
authors.affiliation: Inorganic & Physical Chemistry Division, Indian Institute of Chemical Technology, Hyderabad 500607, India.
authors.forename: Parvathaneni
authors.initials: P
authors.lastname: Sai Prathima
authors.affiliation: Biology Division, Indian Institute of Chemical Technology, Hyderabad 500607, India.
authors.forename: Pamanji
authors.initials: P
authors.lastname: Rajesh
authors.affiliation: Biology Division, Indian Institute of Chemical Technology, Hyderabad 500607, India.
authors.forename: Janapala
authors.initials: J
authors.lastname: Venkateswara Rao
authors.affiliation: National Centre for Cell Sciences, University of Pune Campus, Ganeshkhind, Pune 411007, India.
authors.forename: Uppalapati
authors.initials: U
authors.lastname: Sai Kailash
authors.affiliation: X-ray Crystallography Division, Indian Institute of Chemical Technology, Hyderabad 500607, India.
authors.forename: Balasubramanian
authors.initials: B
authors.lastname: Sridhar
authors.affiliation: Inorganic & Physical Chemistry Division, Indian Institute of Chemical Technology, Hyderabad 500607, India. Electronic address: mandapati@iict.res.in.
authors.forename: Mandapati
authors.initials: M
authors.lastname: Mohan Rao
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D061986:MCF-7 Cells; D008958:Models, Molecular; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D020298:U937 Cells; D014867:Water / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D014867:Water
keywords: 3-Indolyl-3-hydroxy oxindoles; Cytotoxicity; Diethanolamine; Indole; Isatin; Water