title: CCR7: roles in cancer cell dissemination, migration and metastasis formation.
abstract: The CC-chemokine receptor 7 (CCR7) coordinates the migration of cancer cells as well as immune cells towards lymphatic organs where its two ligands CCL19 and CCL21 are constitutively expressed. Here we provide a topological model of CCR7, which belongs to the class A of G-protein coupled, seven-transmembrane spanning receptors, and describe how CCR7 expression is regulated. We focus on its role in cancer cell migration and metastasis formation and discuss how cancer cells can utilize CCR7 or its ligands to escape from immune surveillance.
authors.affiliation: Biotechnology Institute Thurgau (BITg) at the University of Konstanz, Kreuzlingen, Switzerland. Electronic address: daniel.legler@bitg.ch.
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Legler
authors.affiliation: Biotechnology Institute Thurgau (BITg) at the University of Konstanz, Kreuzlingen, Switzerland.
authors.forename: Edith
authors.initials: E
authors.lastname: Uetz-von Allmen
authors.affiliation: Biotechnology Institute Thurgau (BITg) at the University of Konstanz, Kreuzlingen, Switzerland.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Hauser
mesh_terms: D000818:Animals; D002465:Cell Movement; D002633:Chemotaxis; D006801:Humans; D008207:Lymphatic Metastasis; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D054400:Receptors, CCR7 / Q000378:metabolism*
chemical_list: D054400:Receptors, CCR7
keywords: Cancer; Cell migration; Chemokine receptor; Lymph node homing; Metastasis formation