title: The administration of atomoxetine during alcohol deprivation induces a time-limited increase in alcohol consumption after relapse.
abstract: The administration of selective serotonin reuptake inhibitors (SSRIs) typically used as antidepressants increases alcohol consumption after an alcohol deprivation period in rats. However, the appearance of this effect after the treatment with selective noradrenaline reuptake inhibitors (SNRIs) has not been studied. In the present work we examined the effects of a 15-d treatment with the SNRI atomoxetine (1, 3 and 10 mg/kg, i.p.) in male rats trained to drink alcohol solutions in a 4-bottle choice test. The treatment with atomoxetine (10 mg/kg, i.p.) during an alcohol deprivation period increased alcohol consumption after relapse. This effect only lasted one week, disappearing thereafter. Treatment with atomoxetine did not cause a behavioral sensitized response to a challenge dose of amphetamine (1.5 mg/kg, i.p.), indicating the absence of a supersensitive dopaminergic transmission. This effect is markedly different from that of SSRI antidepressants that produced both long-lasting increases in alcohol consumption and behavioral sensitization. Clinical implications are discussed.
authors.affiliation: Departamento de Psicobiología, Facultad de Psicología,Universidad Complutense de Madrid,28224,Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Alén
authors.affiliation: Instituto IBIMA, Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga,Universidad de Málaga,29010,Spain.
authors.forename: Antonia
authors.initials: A
authors.lastname: Serrano
authors.affiliation: Departamento de Psicobiología, Facultad de Psicología,Universidad Complutense de Madrid,28224,Spain.
authors.forename: Miguel Ángel
authors.initials: MÁ
authors.lastname: Gorriti
authors.affiliation: Instituto IBIMA, Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga,Universidad de Málaga,29010,Spain.
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Pavón
authors.affiliation: Instituto IBIMA, Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga,Universidad de Málaga,29010,Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Orio
authors.affiliation: Departamento de Psicobiología, Facultad de Psicología,Universidad Complutense de Madrid,28224,Spain.
authors.forename: Raquel Gómez
authors.initials: RG
authors.lastname: de Heras
authors.affiliation: Departamento de Psicobiología, Facultad de Psicología,Universidad Complutense de Madrid,28224,Spain.
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Ramírez-López
authors.affiliation: Instituto IBIMA, Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga,Universidad de Málaga,29010,Spain.
authors.forename: María
authors.initials: M
authors.lastname: Antón
authors.affiliation: Instituto Pluridisciplinar,Universidad Complutense de Madrid,28224,Spain.
authors.forename: Miguel Ángel
authors.initials: MÁ
authors.lastname: Pozo
authors.affiliation: Departamento de Psicobiología, Facultad de Psicología,Universidad Complutense de Madrid,28224,Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Rodríguez de Fonseca
mesh_terms: D018759:Adrenergic Uptake Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D000428:Alcohol Drinking / Q000188:drug therapy* / Q000503:physiopathology*; D000704:Analysis of Variance; D000818:Animals; D000069445:Atomoxetine Hydrochloride; D002492:Central Nervous System Depressants / Q000008:administration & dosage* / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects; D004195:Disease Models, Animal; D000431:Ethanol / Q000008:administration & dosage*; D008124:Locomotion / Q000187:drug effects; D008297:Male; D011437:Propylamines / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012008:Recurrence; D012646:Self Administration
chemical_list: D018759:Adrenergic Uptake Inhibitors; D002492:Central Nervous System Depressants; D011437:Propylamines; D000431:Ethanol; D000069445:Atomoxetine Hydrochloride