title: Visual detection of blood glucose based on peroxidase-like activity of WS2 nanosheets.
abstract: Tungsten disulfide (WS2) nanosheets were discovered to possess intrinsic peroxidase-like activity and catalyze the peroxidase substrate 3,3',5,5'-tetramethylbenzidine (TMB) to produce a color reaction in the presence of H2O2. Based on this finding, a colorimetric method and a portable test kit for the visual detection of blood glucose have been developed by using glucose oxidase (GOx) and WS2 nanosheets-catalyzed reactions. The linear range for glucose was ranged from 5 to 300 μM (R(2)=0.999) with the detection limit of 2.9 μM. The portable test kit was successfully evaluated glucose levels in serum samples from normal persons and diabetes persons by the observable color change from pale yellow to yellow-green, blue-green.
authors.affiliation: Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou 350108, China.
authors.forename: Tianran
authors.initials: T
authors.lastname: Lin
authors.affiliation: Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou 350108, China.
authors.forename: Liangshuang
authors.initials: L
authors.lastname: Zhong
authors.affiliation: Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou 350108, China.
authors.forename: Zhiping
authors.initials: Z
authors.lastname: Song
authors.affiliation: Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou 350108, China. Electronic address: lqguo@fzu.edu.cn.
authors.forename: Liangqia
authors.initials: L
authors.lastname: Guo
authors.affiliation: Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou 350108, China.
authors.forename: Hanyin
authors.initials: H
authors.lastname: Wu
authors.affiliation: Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou 350108, China.
authors.forename: Qingquan
authors.initials: Q
authors.lastname: Guo
authors.affiliation: Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou 350108, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou 350108, China. Electronic address: fengfu@fzu.edu.cn.
authors.forename: FengFu
authors.initials: F
authors.lastname: Fu
authors.affiliation: Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou 350108, China.
authors.forename: Guonan
authors.initials: G
authors.lastname: Chen
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D001774:Blood Chemical Analysis / Q000379:methods; D001786:Blood Glucose / Q000032:analysis*; D003124:Colorimetry / Q000379:methods*; D003920:Diabetes Mellitus / Q000097:blood; D005949:Glucose Oxidase; D006801:Humans; D006861:Hydrogen Peroxide; D053768:Metal Nanoparticles; D012685:Sepharose; D017973:Tungsten Compounds
chemical_list: D001786:Blood Glucose; D017973:Tungsten Compounds; D012685:Sepharose; D006861:Hydrogen Peroxide; D005949:Glucose Oxidase
keywords: Glucose; Peroxidase; Semiconductor; Sensors; Tungsten disulfide