title: Back-up strategies in drug discovery: what, how and when?
abstract: The management of back-up strategies in drug discovery and development is usually done on an ad hoc basis depending upon a series of external factors including overall portfolio status and resource and/or budget availability. These are however an essential component of risk management and merit a more structured and systematic conduct throughout the lifetime of a project. An approach based upon a thorough alignment of decision points and data availability as well as a tailor-made progression of various types of back-up program as a function of project categorization is suggested.
authors.affiliation: Global Chemistry, UCB NewMedicines, UCB Biopharma, 1420 Braine-L'Alleud, Belgium. Electronic address: laurent.provins@ucb.com.
authors.forename: Laurent
authors.initials: L
authors.lastname: Provins
authors.affiliation: Global Chemistry, UCB NewMedicines, UCB Biopharma, 1420 Braine-L'Alleud, Belgium.
authors.forename: Eric
authors.initials: E
authors.lastname: Jnoff
authors.affiliation: Global Chemistry, UCB NewMedicines, UCB Biopharma, 1420 Braine-L'Alleud, Belgium.
authors.forename: Christophe
authors.initials: C
authors.lastname: Genicot
mesh_terms: D000818:Animals; D003657:Decision Making; D055808:Drug Discovery; D006801:Humans