title: [The study of catheterization to measure ventricular pressure in mice through venous cannula in external jugular vein].
abstract: OBJECTIVE
  To study a feasible method of measuring right ventricular pressure by catheterization in mice.
  
  
  METHODS
  Measuring the right ventricular pressure and the pulmonary artery pressure by homemade PE pipe through venous cannula in external jugular vein, using catheterization in mice with powerlab multimodal biometric signal recording system.
  
  
  RESULTS
  Forty-six out of 51 mice were experimented with this method smoothly and got a total success rate of 90.2%. Thirty of 33 normal mice and 16 of 18 mice with pulmonary arterial hypertension (PAH) were catheterized successfully. The right ventricular pressure were as follow: systolic blood pressure: (23.4 +/- 5.7) mmHg in normal group vs (32.2 +/- 2.8) mmHg in mice with PAH, diastolic blood pressure: (3.7 +/- 2.6) mmHg vs (3.8 +/- 2.0) mmHg, mean pressure: (12.0 +/- 3.7) mmHg vs (14.9 +/- 2.3) mmHg. After autopsy for those 5 failed cases, we found that 2 cases were into the inferior vena cava, another 2 cases pierced the right auricle and the last one punctured the axillary vein into the chest wall.
  
  
  CONCLUSIONS
  Measuring the right ventricular pressure through venous cannula in external jugular vein with homemade PE pipe in mice gets not only a high success rate but also help to save time. Moreover, this method can be popularized easily. It is a good and feasible method for measuring right ventricular pressure in mice.
authors.forename: Pan-Pan
authors.initials: PP
authors.lastname: Liu
authors.forename: Shuang-Quan
authors.initials: SQ
authors.lastname: Yan
authors.forename: Ma-Yun
authors.initials: MY
authors.lastname: Chen
authors.forename: Li-Zhen
authors.initials: LZ
authors.lastname: Zou
authors.forename: Xiao-Ying
authors.initials: XY
authors.lastname: Huang
authors.forename: Liang-Xing
authors.initials: LX
authors.lastname: Wang
mesh_terms: D000818:Animals; D006328:Cardiac Catheterization / Q000379:methods*; D007601:Jugular Veins; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D017725:Ventricular Pressure