title: Dynamic regulation of host restriction factor expression over the course of HIV-1 infection in vivo.
abstract: In this study, we investigated the expression levels of host restriction factors in six untreated HIV-1-positive patients over the course of infection. We found that the host restriction factor gene expression profile consistently increased over time and was significantly associated with CD4+ T cell activation and viral load. Our data are among the first to demonstrate the dynamic nature of host restriction factors in vivo over time.
authors.affiliation: Division of Experimental Medicine, University of California San Francisco, San Francisco, California, USA Department of Microbiology, Immunology and Tropical Medicine, The George Washington University, Washington, DC, USA araposo@gwu.edu.
authors.forename: Rui André Saraiva
authors.initials: RA
authors.lastname: Raposo
authors.affiliation: Department of Medicine, University of California San Francisco, San Francisco, California, USA Blood Systems Research Institute, San Francisco, California, USA.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Abdel-Mohsen
authors.affiliation: Blood Systems Research Institute, San Francisco, California, USA.
authors.forename: Xutao
authors.initials: X
authors.lastname: Deng
authors.affiliation: UCSF Positive Health Program, San Francisco General Hospital, University of California San Francisco, San Francisco, California, USA.
authors.forename: Frederick M
authors.initials: FM
authors.lastname: Hecht
authors.affiliation: UCSF Positive Health Program, San Francisco General Hospital, University of California San Francisco, San Francisco, California, USA.
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Pilcher
authors.affiliation: Blood Systems Research Institute, San Francisco, California, USA Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA.
authors.forename: Satish K
authors.initials: SK
authors.lastname: Pillai
authors.affiliation: Division of Experimental Medicine, University of California San Francisco, San Francisco, California, USA Department of Microbiology, Immunology and Tropical Medicine, The George Washington University, Washington, DC, USA.
authors.forename: Douglas F
authors.initials: DF
authors.lastname: Nixon
mesh_terms: D000328:Adult; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000821:virology; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology / Q000378:metabolism / Q000821:virology; D015497:HIV-1 / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D008137:Longitudinal Studies; D008213:Lymphocyte Activation; D008297:Male; D012367:RNA, Viral / Q000235:genetics* / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics* / Q000378:metabolism; D019562:Viral Load
chemical_list: D012367:RNA, Viral; D012097:Repressor Proteins