title: Isolation of diploid baker's yeast capable of strongly activating immune cells and analyses of the cell wall structure.
abstract: Diploid baker's yeast capable of strongly activating a mouse macrophage was constructed based on haploid mutant AQ-37 obtained previously. The obtained strain BQ-55 activated also human immune cells. To clarify a factor for the activation, the cell wall structure, especially the β-glucan structure, was analyzed, suggesting that the length of branching, β-1,6-glucan, may be one of the factors.
authors.affiliation: a Department of Applied Chemistry and Bioengineering , Graduate School of Engineering, Osaka City University , Osaka , Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Takada
authors.forename: Ayano
authors.initials: A
authors.lastname: Mizobuchi
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kato
authors.forename: Emiko
authors.initials: E
authors.lastname: Kasahara
authors.forename: Chinatsu
authors.initials: C
authors.lastname: Ito
authors.forename: Hajime
authors.initials: H
authors.lastname: Watanabe
authors.forename: Ken
authors.initials: K
authors.lastname: Kanzaki
authors.forename: Seiichi
authors.initials: S
authors.lastname: Kitagawa
authors.forename: Taro
authors.initials: T
authors.lastname: Tachibana
authors.forename: Masayuki
authors.initials: M
authors.lastname: Azuma
mesh_terms: D000818:Animals; D002473:Cell Wall / Q000737:chemistry*; D004171:Diploidy; D006801:Humans; D007109:Immunity; D008262:Macrophage Activation / Q000276:immunology; D051379:Mice; D012441:Saccharomyces cerevisiae / Q000166:cytology* / Q000235:genetics / Q000502:physiology*; D012995:Solubility; D047071:beta-Glucans / Q000737:chemistry
chemical_list: D047071:beta-Glucans
keywords: macrophage; mannan; mononuclear cells; yeast; β-glucan