title: The clinical research for Ganoderan's effect on preventing and treating cerebral arteriosclerosis through inhibiting NADPH oxidizing enzyme expression.
abstract: A lot of researches have verified that produced excessive reactive oxygen is one of the hazard factors causing atherosclerosis. NADPH oxidase is the main protease of vascular cell's producing reactive oxygen, the expression of its relevant subunits is closely correlated with the occurring and development process of atherosclerosis. Oxidizing reaction could damage organism tissue cells, ganoderan has very significant effect on the anti-oxidizing function of cell. The pharmaceutical research of ganoderan has significant meaning in curing diabetes mellitus, preventing and controlling arteriosclerosis. This paper is mainly to discuss the effect of anoderan's inhibiting NADPH oxidizing enzyme expression on preventing and treating cerebral arteriosclerosis and its action mechanism.
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.
authors.forename: Zhang Li
authors.initials: ZL
authors.lastname: Feng
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.
authors.forename: Teng Jun
authors.initials: TJ
authors.lastname: Fang
authors.affiliation: Department of Neurology, Zhengzhou people's Hospital, Zhengzhou, Henan Province, China.
authors.forename: Yuan Xue
authors.initials: YX
authors.lastname: Qian
authors.affiliation: Department of Neurology, Zhengzhou people's Hospital, Zhengzhou, Henan Province, China.
authors.forename: Wang Huan
authors.initials: WH
authors.lastname: Rong
mesh_terms: D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D002537:Intracranial Arteriosclerosis / Q000517:prevention & control*; D008297:Male; D019255:NADPH Oxidases / Q000037:antagonists & inhibitors*; D011134:Polysaccharides / Q000494:pharmacology*; D051381:Rats
chemical_list: D004791:Enzyme Inhibitors; D011134:Polysaccharides; C047406:ganoderan A; C047407:ganoderan B; D019255:NADPH Oxidases