title: Time- and frequency-domain parameters of heart rate variability and sympathetic skin response in Parkinson's disease.
abstract: The autonomic nervous system (ANS) is regularly affected in Parkinson's disease (PD). Information on autonomic dysfunction can be derived from e.g. altered heart rate variability (HRV) and sympathetic skin response (SSR). Such parameters can be quantified easily and measured repeatedly which might be helpful for evaluating disease progression and therapeutic outcome. In this 2-center study, HRV and SSR of 45 PD patients and 26 controls were recorded. HRV was measured during supine metronomic breathing and analyzed in time- and frequency-domains. SSR was evoked by repetitive auditory stimulation. Various ANS parameters were compared (1) between patients and healthy controls, (2) to clinical scales (Unified Parkinson's disease rating scale, Mini-Mental State Examination, Becks Depression Inventory), and (3) to disease duration. Root mean square of successive differences (RMSSD) and low frequency/high frequency (LF/HF) ratio differed significantly between PD and controls. Both, HRV and SSR parameters showed low or no association with clinical scores. Time-domain parameters tended to be affected already at early PD stages but did not consistently change with longer disease duration. In contrast, frequency-domain parameters were not altered in early PD phases but tended to be lower (LF, LF/HF ratio), respectively higher (HF) with increasing disease duration. This report confirms previous results of altered ANS parameters in PD. In addition, it suggests that (1) these ANS parameters are not relevantly associated with motor, behavioral, and cognitive changes in PD, (2) time-domain parameters are useful for the assessment of early PD, and (3) frequency-domain parameters are more closely associated with disease duration.
authors.affiliation: Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany, walter.maetzler@uni-tuebingen.de.
authors.forename: Walter
authors.initials: W
authors.lastname: Maetzler
authors.forename: Marie
authors.initials: M
authors.lastname: Karam
authors.forename: Monika Fruhmann
authors.initials: MF
authors.lastname: Berger
authors.forename: Tanja
authors.initials: T
authors.lastname: Heger
authors.forename: Corina
authors.initials: C
authors.lastname: Maetzler
authors.forename: Heinz
authors.initials: H
authors.lastname: Ruediger
authors.forename: Juliana
authors.initials: J
authors.lastname: Bronzova
authors.forename: Patricia Pita
authors.initials: PP
authors.lastname: Lobo
authors.forename: Joaquim J
authors.initials: JJ
authors.lastname: Ferreira
authors.forename: Tjalf
authors.initials: T
authors.lastname: Ziemssen
authors.forename: Daniela
authors.initials: D
authors.lastname: Berg
mesh_terms: D000161:Acoustic Stimulation; D000368:Aged; D001341:Autonomic Nervous System / Q000503:physiopathology; D004562:Electrocardiography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D005712:Galvanic Skin Response / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D007361:Intelligence Tests; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology*; D013997:Time Factors