title: Renal denervation for refractory ventricular arrhythmias.
abstract: The autonomic nervous system is known to play a significant role in the genesis and persistence of arrhythmias. Neuromodulation has become a new therapeutic strategy for the treatment of ventricular arrhythmias. Catheter-based renal denervation (RDN) is being studied as a treatment option for drug-refractory hypertension. Ablation within the renal arteries, by altering efferent and afferent signaling, has the potential to improve blood pressure, as well as heart failure, atrial, and ventricular tachyarrhythmias. We present a brief review of the anatomic and pathophysiological rationale for RDN as an adjunctive treatment for ventricular tachyarrhythmias.
authors.affiliation: UCLA Cardiac Arrhythmia Center, Ronald Reagan UCLA Health System, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
authors.forename: Jason S
authors.initials: JS
authors.lastname: Bradfield
authors.affiliation: UCLA Cardiac Arrhythmia Center, Ronald Reagan UCLA Health System, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
authors.forename: Marmar
authors.initials: M
authors.lastname: Vaseghi
authors.affiliation: UCLA Cardiac Arrhythmia Center, Ronald Reagan UCLA Health System, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. Electronic address: KShivkumar@mednet.ucla.edu.
authors.forename: Kalyanam
authors.initials: K
authors.lastname: Shivkumar
mesh_terms: D000818:Animals; D017763:Autonomic Denervation / Q000009:adverse effects / Q000379:methods*; D017115:Catheter Ablation / Q000009:adverse effects; D006339:Heart Rate; D006801:Humans; D007668:Kidney / Q000294:innervation*; D017180:Tachycardia, Ventricular / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D016896:Treatment Outcome