title: Association of the +331G/A progesterone receptor gene (PgR) polymorphism with risk of endometrial cancer in Caucasian women: a meta-analysis.
abstract: OBJECTIVE
  The +331G/A progesterone receptor (PgR) gene polymorphism may influence risk of endometrial cancer. However, data from published studies have been controversial. To evaluate whether combined evidence shows an association between this polymorphism and endometrial cancer, we considered all available studies in a meta-analysis.
  
  
  METHODS
  We searched PubMed and EMBASE and identified eight studies representing data for 3,790 cases and 6,458 controls. We estimated risk [odds ratio (OR) and 95 % confidence interval] of these associations, which were non-significant in the entire body of results.
  
  
  RESULTS
  Overall effects indicated increased risks, slightly pronounced in the homozygous and recessive models (OR 1.16-1.17, p = 0.57-0.60). These effects were exacerbated when confined to studies in Hardy-Weinberg Equilibrium (OR 1.33-1.36, p = 0.33-0.35) and in the underpowered subgroup (OR 1.62-1.68, p = 0.27-0.30). The exception is the powered subgroup which showed reduced risk (OR 0.96-0.97, p = 0.92-0.93). None of the comparisons were heterogeneous, in fact, 10 of the 16 comparisons had zero heterogeneity (I (2) = 0 %).
  
  
  CONCLUSIONS
  In summary, the non-significant results suggest that the PgR +331G/A polymorphism might not be a conspicuous low-penetrant risk factor for developing endometrial cancer.
authors.affiliation: School of Natural Sciences and Nursing, Saint Louis University, Baguio, 2600, Philippines.
authors.forename: Noel
authors.initials: N
authors.lastname: Pabalan
authors.forename: Maria Ruth
authors.initials: MR
authors.lastname: Pineda
authors.forename: Hamdi
authors.initials: H
authors.lastname: Jarjanazi
authors.forename: Denise M
authors.initials: DM
authors.lastname: Christofolini
authors.forename: Caio Parente
authors.initials: CP
authors.lastname: Barbosa
authors.forename: Bianca
authors.initials: B
authors.lastname: Bianco
mesh_terms: D016889:Endometrial Neoplasms / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011980:Receptors, Progesterone / Q000235:genetics*; D012306:Risk; D012307:Risk Factors
chemical_list: D011980:Receptors, Progesterone