title: Computer aided screening of secreted frizzled-related protein 4 (SFRP4): a potential control for diabetes mellitus.
abstract: Diabetes mellitus is a life threatening disease and scientists are doing their best to find a cost effective and permanent treatment of this malady. The recent trend is to control the disease by target base inhibiting of enzymes or proteins. Secreted frizzled-related protein 4 (SFRP4) is found to cause five times more risk of diabetes when expressed above average levels. This study was therefore designed to analyze the SFRP4 and to find its potential inhibitors. SFRP4 was analyzed by bio-informatics tools of sequence tool and structure tool. A total of three potential inhibitors of SFRP4 were found, namely cyclothiazide, clopamide and perindopril. These inhibitors showed significant interactions with SFRP4 as compared to other inhibitors as well as control (acetohexamide). The findings suggest the possible treatment of diabetes mellitus type 2 by inhibiting the SFRP4 using the inhibitors cyclothiazide, clopamide and perindopril.
authors.affiliation: Department of Applied Chemistry and Biochemistry, Government College University, Allama Iqbal Road, Faisalabad 38000, Pakistan. bukhari.shazia@yahoo.com.
authors.forename: Shazia Anwer
authors.initials: SA
authors.lastname: Bukhari
authors.affiliation: Department of Applied Chemistry and Biochemistry, Government College University, Allama Iqbal Road, Faisalabad 38000, Pakistan. waseem_shamshari@yahoo.com.
authors.forename: Waseem Akhtar
authors.initials: WA
authors.lastname: Shamshari
authors.affiliation: Department of Bioinformatics and Biotechnology, Government College University, Allama Iqbal Road, Faisalabad 38000, Pakistan. mahmood1233@yahoo.com.
authors.forename: Mahmood
authors.initials: M
authors.lastname: Ur-Rahman
authors.affiliation: The Patent Office, Karachi 74400, Pakistan. ahirzia@gmail.com.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Zia-Ul-Haq
authors.affiliation: Department of Crop Science, Faculty of Agriculture, University Putra Malaysia, Serdang 43400, Selangor, Malaysia. hawazej@gmail.com.
authors.forename: Hawa Z E
authors.initials: HZ
authors.lastname: Jaafar
mesh_terms: D003198:Computer Simulation; D003920:Diabetes Mellitus / Q000188:drug therapy*; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000627:therapeutic use; D062105:Molecular Docking Simulation; D011518:Proto-Oncogene Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry; D000094742:Secreted Frizzled-Related Proteins
chemical_list: D007004:Hypoglycemic Agents; D011518:Proto-Oncogene Proteins; C118723:SFRP4 protein, human; D000094742:Secreted Frizzled-Related Proteins