title: Lipoprotein particle concentrations in children and adults following Kawasaki disease.
abstract: OBJECTIVE
  To test the hypothesis that children and adults with a history of Kawasaki disease (KD) are more likely to have abnormal lipoprotein particle profiles that could place them at increased risk for developing atherosclerosis later in life.
  
  
  METHODS
  Fasting serum samples were obtained from 192 children and 63 adults with history of KD and 90 age-similar healthy controls. Lipoprotein particle concentrations and sizes were measured by nuclear magnetic resonance spectroscopy (LipoScience Inc, Raleigh, North Carolina), and serum was assayed for total cholesterol (TC), triglycerides, and high-density lipoprotein (HDL) cholesterol (HDL-C). Low-density lipoprotein (LDL) cholesterol was estimated using the Friedewald formula. Data were analyzed in a least-square means model, with adjustment for age and sex and with the use of Holm correction for multiple comparisons.
  
  
  RESULTS
  Compared with respective control groups, both adult and pediatric subjects with KD had significantly lower mean very low-density lipoprotein-chylomicron particles, intermediate-density lipoproteins, triglycerides, and TC concentrations. Pediatric subjects with KD had significantly lower LDL particle and LDL cholesterol concentrations and lower mean TC/HDL-C ratio (P < .001). In contrast, the adult subjects with KD had significantly lower HDL particle, small HDL particle, and HDL-C concentrations (P < .001), but HDL-C was within normal range.
  
  
  CONCLUSIONS
  Nuclear magnetic resonance lipoprotein particle analysis suggests that pediatric and adult subjects with KD, regardless of their aneurysm status, are no more likely than age-similar, healthy controls to have lipid patterns associated with increased risk of atherosclerosis.
authors.affiliation: Department of Pediatrics, University of California, San Diego, La Jolla, CA; Rady Children's Hospital San Diego, San Diego, CA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Lin
authors.affiliation: Division of Biostatistics and Bioinformatics, Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA.
authors.forename: Sonia
authors.initials: S
authors.lastname: Jain
authors.affiliation: Division of Biostatistics and Bioinformatics, Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Sun
authors.affiliation: Department of Pediatrics, University of California, San Diego, La Jolla, CA; Rady Children's Hospital San Diego, San Diego, CA.
authors.forename: Victoria
authors.initials: V
authors.lastname: Liu
authors.affiliation: Department of Pediatrics, University of California, San Diego, La Jolla, CA; Rady Children's Hospital San Diego, San Diego, CA.
authors.forename: Yuichiro Z
authors.initials: YZ
authors.lastname: Sato
authors.affiliation: Department of Pediatrics, University of California, San Diego, La Jolla, CA; Rady Children's Hospital San Diego, San Diego, CA.
authors.forename: Susan
authors.initials: S
authors.lastname: Jimenez-Fernandez
authors.affiliation: Department of Pediatrics, University of California, San Diego, La Jolla, CA; Rady Children's Hospital San Diego, San Diego, CA.
authors.forename: Ron S
authors.initials: RS
authors.lastname: Newfield
authors.affiliation: Department of Medical Affairs, LipoScience, Inc, Raleigh, NC.
authors.forename: Ray
authors.initials: R
authors.lastname: Pourfarzib
authors.affiliation: Department of Pediatrics, University of California, San Diego, La Jolla, CA; Rady Children's Hospital San Diego, San Diego, CA.
authors.forename: Adriana H
authors.initials: AH
authors.lastname: Tremoulet
authors.affiliation: Sharp Memorial Hospital and San Diego Cardiac Center, San Diego, CA.
authors.forename: John B
authors.initials: JB
authors.lastname: Gordon
authors.affiliation: Division of Cardiology, Department of Medicine, University of California, San Diego, La Jolla, CA.
authors.forename: Lori B
authors.initials: LB
authors.lastname: Daniels
authors.affiliation: Department of Pediatrics, University of California, San Diego, La Jolla, CA; Rady Children's Hospital San Diego, San Diego, CA. Electronic address: jcburns@ucsd.edu.
authors.forename: Jane C
authors.initials: JC
authors.lastname: Burns
mesh_terms: D000293:Adolescent; D000328:Adult; D050197:Atherosclerosis / Q000097:blood; D015992:Body Mass Index; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D002914:Chylomicrons / Q000737:chemistry*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008074:Lipoproteins / Q000097:blood* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood* / Q000628:therapy; D012307:Risk Factors; D055815:Young Adult
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D002914:Chylomicrons; D008074:Lipoproteins