title: [Role of renal inflammation in the physiopathology of salt-sensitive hypertension].
abstract: Salt-sensitive hypertension is produced by a decrease in salt renal excretion after a salt overload. Over the last few years, a new theory has been developed to explain this condition based on renal tissue inflammation. This process begins with free radicals production in renal tissue due to oxidative metabolism. Then they favor a renal inflammation mechanism with T-lymphocytes infiltration and other immune cells. Essentially, T-lymphocytes determine an increase in angiotensin ii production which raises sodium and water retention. Association among autoimmune diseases and hypertension may be explained, in part, by the relationship between salt-sensitive hypertension and renal inflammation. The use of antioxidant drugs and the development of new medicaments may be a choice for treating patients affected with this condition.
authors.affiliation: Facultad de Medicina, Universidad de Ciencias Médicas Dr. Serafín Ruiz de Zárate Ruiz, Santa Clara, Villa Clara, Cuba. Electronic address: yanielct@edu.vcl.sld.cu.
authors.forename: Yaniel
authors.initials: Y
authors.lastname: Castro Torres
authors.affiliation: Facultad de Medicina, Universidad de Ciencias Médicas Dr. Serafín Ruiz de Zárate Ruiz, Santa Clara, Villa Clara, Cuba.
authors.forename: Alejandro Emilio
authors.initials: AE
authors.lastname: Santos Portela
authors.affiliation: Policlínico Docente Universitario José Ramón León Acosta, Santa Clara, Villa Clara, Cuba.
authors.forename: Ildiko María
authors.initials: IM
authors.lastname: Garrido Bősze
mesh_terms: D001327:Autoimmune Diseases / Q000150:complications; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000209:etiology* / Q000503:physiopathology*; D009393:Nephritis / Q000150:complications / Q000503:physiopathology*; D018384:Oxidative Stress; D017673:Sodium Chloride, Dietary / Q000378:metabolism*
chemical_list: D017673:Sodium Chloride, Dietary
keywords: Cuba; Estrés oxidativo; Hipertensión sensible a sal; Inflamación renal; Linfocitos T; Macrophages; Macrófagos; Oxidative stress; Renal inflammation; Salt-sensitive hypertension; T-lymphocytes