title: Foreign body giant cell reaction to tarSys™ xenograft.
abstract: OBJECTIVE
  A foreign body giant cell (FBGC) reaction may occur in response to implanted xenogenic biomaterials. Here we report a FBGC reaction to the recently introduced xenogenic biomaterial, tarSys™, used for correction of lower eyelid retraction.
  
  
  METHODS
  A retrospective chart review of two patients with FBGC reaction to tarSys™ implantation was performed.
  
  
  RESULTS
  Two patients (aged 51, 58 year) with lower eyelid retraction underwent surgical implantation of tarSys™ spacer grafts for correction. Both patients subsequently experienced chronic swelling requiring graft removal. Examination of the specimens showed a palisading FBGC reaction around acellular pink fibrillar material.
  
  
  CONCLUSIONS
  A FBGC reaction may follow implantation of the tarSys™ xenograft.
authors.affiliation: Yale-New Haven Hospital, Department of Pathology, New Haven, CT, USA.
authors.forename: William R
authors.initials: WR
authors.lastname: Munday
authors.forename: Zachary
authors.initials: Z
authors.lastname: Klett
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: McNiff
authors.forename: Christine
authors.initials: C
authors.lastname: Ko
mesh_terms: D001672:Biocompatible Materials / Q000008:administration & dosage / Q000009:adverse effects*; D005143:Eyelids / Q000473:pathology / Q000601:surgery*; D005260:Female; D005549:Foreign-Body Reaction / Q000473:pathology*; D015743:Giant Cells, Foreign-Body / Q000276:immunology / Q000473:pathology; D006084:Graft Rejection / Q000175:diagnosis; D064593:Heterografts / Q000637:transplantation*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D001672:Biocompatible Materials
keywords: allograft; eyelid; foreign body giant cell reaction; rejection; xenograft