title: Aberrant EEG functional connectivity and EEG power spectra in resting state post-traumatic stress disorder: a sLORETA study.
abstract: The aim of the present study was to explore the modifications of EEG power spectra and EEG connectivity of resting state (RS) condition in patients with post-traumatic stress disorder (PTSD). Seventeen patients and seventeen healthy subjects matched for age and gender were enrolled. EEG was recorded during 5min of RS. EEG analysis was conducted by means of the standardized Low Resolution Electric Tomography software (sLORETA). In power spectra analysis PTSD patients showed a widespread increase of theta activity (4.5-7.5Hz) in parietal lobes (Brodmann Area, BA 7, 4, 5, 40) and in frontal lobes (BA 6). In the connectivity analysis PTSD patients also showed increase of alpha connectivity (8-12.5Hz) between the cortical areas explored by Pz-P4 electrode. Our results could reflect the alteration of memory systems and emotional processing consistently altered in PTSD patients.
authors.affiliation: Department of Human Sciences, European University of Rome, Italy. Electronic address: imperatori.c@libero.it.
authors.forename: Claudio
authors.initials: C
authors.lastname: Imperatori
authors.affiliation: Department of Human Sciences, European University of Rome, Italy; Unit for Treatment of Trauma, Centro Clinico De Sanctis, Rome, Italy.
authors.forename: Benedetto
authors.initials: B
authors.lastname: Farina
authors.affiliation: Department of Human Sciences, European University of Rome, Italy.
authors.forename: Maria Isabella
authors.initials: MI
authors.lastname: Quintiliani
authors.affiliation: Unit for Treatment of Trauma, Centro Clinico De Sanctis, Rome, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Onofri
authors.affiliation: Unit for Treatment of Trauma, Centro Clinico De Sanctis, Rome, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Castelli Gattinara
authors.affiliation: Unit for Treatment of Trauma, Centro Clinico De Sanctis, Rome, Italy.
authors.forename: Marta
authors.initials: M
authors.lastname: Lepore
authors.affiliation: Institute of Neurology, Catholic University, Rome, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Gnoni
authors.affiliation: Institute of Neurology, Catholic University, Rome, Italy.
authors.forename: Edoardo
authors.initials: E
authors.lastname: Mazzucchi
authors.affiliation: Department of Human Sciences, European University of Rome, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Contardi
authors.affiliation: Institute of Neurology, Catholic University, Rome, Italy.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Della Marca
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology; D016022:Case-Control Studies; D004569:Electroencephalography; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008568:Memory; D008875:Middle Aged; D010296:Parietal Lobe / Q000503:physiopathology*; D013057:Spectrum Analysis; D013313:Stress Disorders, Post-Traumatic / Q000503:physiopathology*; D055815:Young Adult
keywords: EEG Power Spectra; Functional connectivity; PTSD; sLORETA