title: Feasibility and efficacy of intraperitoneal docetaxel administration as salvage chemotherapy for malignant gynaecological ascites.
abstract: Ovarian and endometrial cancers diagnosed at advanced stages are often associated with malignant ascites. This study aimed to determine the safety, feasibility and efficacy of intraperitoneal (IP) docetaxel (TXT) for the treatment of ascites. A phase I study, including nine patients, was undertaken to determine the maximum tolerable dose. Efficacy was retrospectively assessed in 18 patients treated with 40-70 mg/m(2) IP TXT between 2005 and 2012. In a phase I study, the dose was safely escalated to a maximum of 70 mg/m(2), at which level no patients had grade -3 haematological adverse events. In a retrospective study of 18 patients, seven had an Eastern Cooperative Oncology Group performance status of 3; 16 had prior paclitaxel administration and two, with doses of 40 and 70 mg/m(2), experienced a serological response and a decrease in paracentesis. Thus, palliative treatment of recurrent OC should be further studied with 40 mg/m(2) among more patients, and 70 mg/m(2) could be evaluated for first-line IP chemotherapy.
authors.affiliation: Department of Obstetrics and Gynecology, Hyogo College of Medicine , Nishinomiya , Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tsubamoto
authors.forename: S
authors.initials: S
authors.lastname: Takeuchi
authors.forename: K
authors.initials: K
authors.lastname: Ito
authors.forename: Y
authors.initials: Y
authors.lastname: Miyagi
authors.forename: S
authors.initials: S
authors.lastname: Toyoda
authors.forename: K
authors.initials: K
authors.lastname: Inoue
authors.forename: R
authors.initials: R
authors.lastname: Kanazawa
authors.forename: Y
authors.initials: Y
authors.lastname: Hosoda
authors.forename: H
authors.initials: H
authors.lastname: Shibahara
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000150:complications / Q000188:drug therapy*; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001201:Ascites / Q000188:drug therapy* / Q000209:etiology; D000077143:Docetaxel; D005240:Feasibility Studies; D005260:Female; D005833:Genital Neoplasms, Female / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007263:Infusions, Parenteral; D008875:Middle Aged; D012189:Retrospective Studies; D016879:Salvage Therapy; D043823:Taxoids / Q000008:administration & dosage*
chemical_list: D000970:Antineoplastic Agents; D043823:Taxoids; D000077143:Docetaxel
keywords: Docetaxel; endometrial cancer; intraperitoneal chemotherapy; ovarian cancer; salvage chemotherapy