title: The immunopathology of cutaneous lupus erythematosus.
abstract: Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by the development of autoantibodies and immunologic attack of different organ systems, including the skin. This review aims to provide an overview of some of the pathogenic processes that may be important in the development of SLE, specifically cutaneous lupus erythematosus, and then illustrates how therapies might be tailored to modify these processes and treat disease.
authors.affiliation: Department of Dermatology and Skin Science, University of British Columbia, 835 West 10th Avenue, Vancouver, British Columbia V5Z 4E8, Canada.
authors.forename: Mark G
authors.initials: MG
authors.lastname: Kirchhof
authors.affiliation: Department of Dermatology and Skin Science, University of British Columbia, 835 West 10th Avenue, Vancouver, British Columbia V5Z 4E8, Canada; Child and Family Research Institute, University of British Columbia, 950 West 28th Avenue, Vancouver, British Columbia V5Z 4H4, Canada. Electronic address: Jan.Dutz@vch.ca.
authors.forename: Jan P
authors.initials: JP
authors.lastname: Dutz
mesh_terms: D015551:Autoimmunity / Q000187:drug effects / Q000528:radiation effects; D018450:Disease Progression; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects / Q000528:radiation effects; D056747:Immunomodulation; D016898:Interferon-alpha / Q000378:metabolism*; D008178:Lupus Erythematosus, Cutaneous / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D012307:Risk Factors; D014466:Ultraviolet Rays / Q000009:adverse effects
chemical_list: D016898:Interferon-alpha
keywords: Chemokine; Cutaneous lupus erythematosus; Cytokine; Discoid lupus erythematosus; Interferon-α