title: Cellulose acetate butyrate/poly(caprolactonetriol) blends: Miscibility, mechanical properties, and in vivo inflammatory response.
abstract: This study reports the results of the characterization of cellulose acetate butyrate and polycaprolactone-triol blends in terms of miscibility, swelling capacity, mechanical properties, and inflammatory response in vivo. The cellulose acetate butyrate film was opaque and rigid, with glass transition (T g ) at 134℃ and melting temperature of 156℃. The cellulose acetate butyrate/polycaprolactone-triol films were transparent up to a polycaprolactone-triol content of 60%. T g of the cellulose acetate butyrate films decreased monotonically as polycaprolactone-triol was added to the blend, thus indicating miscibility. FTIR spectroscopy revealed a decrease in intramolecular hydrogen bonding in polycaprolactone-triol, whereas no hydrogen bonding was observed between cellulose acetate butyrate and -OH from polycaprolactone-triol. The increase in polycaprolactone-triol content in the blend decreased the water uptake. An increase in polycaprolactone-triol content decreased the modulus of elasticity and increased the elongation at break. A cellulose acetate butyrate/polycaprolactone-triol 70/30 blend implanted in rats showed only an acute inflammatory response 7 days after surgery. No change in inflammation mediators was observed.
authors.affiliation: TECFARMA, University of Southern Santa Catarina, Tubarão, SC, Brazil Post Graduated Program in Health Science, University of Southern Santa Catarina, Tubarão, SC, Brazil.
authors.forename: Luiz A
authors.initials: LA
authors.lastname: Kanis
authors.affiliation: TECFARMA, University of Southern Santa Catarina, Tubarão, SC, Brazil.
authors.forename: Ellen L
authors.initials: EL
authors.lastname: Marques
authors.affiliation: TECFARMA, University of Southern Santa Catarina, Tubarão, SC, Brazil.
authors.forename: Karine M
authors.initials: KM
authors.lastname: Zepon
authors.affiliation: Post Graduated Program in Health Science, University of Southern Santa Catarina, Tubarão, SC, Brazil jeffripe@rocketmail.com.
authors.forename: Jefferson R
authors.initials: JR
authors.lastname: Pereira
authors.affiliation: Post Graduated Program in Health Science, University of Southern Santa Catarina, Tubarão, SC, Brazil.
authors.forename: Saulo
authors.initials: S
authors.lastname: Pamato
authors.affiliation: Post Graduated Program in Health Science, University of Southern Santa Catarina, Tubarão, SC, Brazil.
authors.forename: Marcelo T
authors.initials: MT
authors.lastname: de Oliveira
authors.affiliation: LAFICEXP, Universidade University of Southern Santa Catarina, Tubarão, SC, Brazil.
authors.forename: Lucinéia G
authors.initials: LG
authors.lastname: Danielski
authors.affiliation: LAFICEXP, Universidade University of Southern Santa Catarina, Tubarão, SC, Brazil.
authors.forename: Fabricia C
authors.initials: FC
authors.lastname: Petronilho
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D015374:Biosensing Techniques; D002152:Calorimetry, Differential Scanning; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D016503:Drug Delivery Systems; D004548:Elasticity; D006860:Hydrogen Bonding; D007249:Inflammation; D008297:Male; D008422:Materials Testing; D011091:Polyesters / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared; D013314:Stress, Mechanical; D013696:Temperature; D013718:Tensile Strength
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; C016240:polycaprolactone; D002482:Cellulose; C014396:cellulose acetate-butyrate
keywords: Cellulose acetate butyrate; blend; inflammatory; miscibility; polycaprolactone-triol