title: Positive and negative effects of glitazones in carcinogenesis: experimental models vs. clinical practice.
abstract: Diabetes increases cancer risk, which may be modulated by careful choice of treatment. Experimental reports showed efficacy of glitazones in various in vitro and in vivo models of carcinogenesis, but procarcinogenic effects in some models were reported too, and, similarly, data on cancer incidence in glitazone users are inconsistent. This review summarizes oncostatic effects of glitazones in preclinical and clinical studies and brings a brief summary of their impact on cancer risk in diabetic patients, with a focus on the association between pioglitazone use and bladder cancer.
authors.affiliation: Department of Animal Physiology, Faculty of Science, Institute of Biology and Ecology, P.J. Šafárik University, Moyzesova 11, 041 67 Košice, Slovak Republic. Electronic address: bianka.bojkova@upjs.sk.
authors.forename: Bianka
authors.initials: B
authors.lastname: Bojková
authors.affiliation: Department of Animal Physiology, Faculty of Science, Institute of Biology and Ecology, P.J. Šafárik University, Moyzesova 11, 041 67 Košice, Slovak Republic.
authors.forename: Peter
authors.initials: P
authors.lastname: Orendáš
authors.affiliation: Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University, Malá Hora 4, 037 54 Martin, Slovak Republic.
authors.forename: Peter
authors.initials: P
authors.lastname: Kubatka
authors.affiliation: Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University, Malá Hora 4, 037 54 Martin, Slovak Republic.
authors.forename: Martin
authors.initials: M
authors.lastname: Péč
authors.affiliation: Department of Animal Physiology, Faculty of Science, Institute of Biology and Ecology, P.J. Šafárik University, Moyzesova 11, 041 67 Košice, Slovak Republic.
authors.forename: Monika
authors.initials: M
authors.lastname: Kassayová
authors.affiliation: Department of Animal Physiology, Faculty of Science, Institute of Biology and Ecology, P.J. Šafárik University, Moyzesova 11, 041 67 Košice, Slovak Republic.
authors.forename: Terézia
authors.initials: T
authors.lastname: Kisková
authors.affiliation: Department of Pathology, Slovak Medical University and St. Elisabeth Oncology Institute, Heydukova 10, 811 08 Bratislava, Slovak Republic.
authors.forename: Karol
authors.initials: K
authors.lastname: Kajo
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000187:drug effects*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy*; D004195:Disease Models, Animal; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy* / Q000209:etiology; D045162:Thiazolidinediones / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D007004:Hypoglycemic Agents; D045162:Thiazolidinediones
keywords: Bladder cancer; Cancer; Glitazones; Pioglitazone