title: Feasibility and precision of subcutaneous continuous glucose monitoring in patients undergoing CABG surgery.
abstract: OBJECTIVE
  To evaluate if subcutaneous continuous glucose monitoring (sCGM) is feasible in cardiac surgery and if reliable glucose values are reported under hypothermic extracorporeal circulation.
  
  
  METHODS
  Feasibility trial.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Ten consecutive patients undergoing coronary artery bypass grafting.
  
  
  METHODS
  Prior to surgery, during hypothermic extracorporeal bypass, and 48 hours postoperatively, arterial blood glucose samples were compared with sCGM every 30 minutes. Statistical analysis utilized Clarke's error grid and Bland-Altman plot.
  
  
  RESULTS
  Three hundred fifty-one pairs of glucose measurements were recorded including 59 during hypothermic extracorporeal circulation. Agreement between these measurements was acceptable, with a regression line slope of 0.88 and an offset of 17.4 (p = 0.87). Error grid analysis indicated a safe margin of 99.1% within zone A (no clinical action needed) or zone B (values would not lead to inappropriate treatment). Only 0.9% were plotted in zone D (potentially dangerous failure). Measurements during hypothermic extracorporeal circulation were comparable. Correlation coefficient was 0.760. The offset regression line was more pronounced (50.9) with a flatter slope (0.640). Within the error grid all plot values were in zone A or B.
  
  
  CONCLUSIONS
  sCGM compared with arterial blood gas glucose monitoring under hypothermic extracorporeal circulation appears to be feasible and reliable.
authors.affiliation: Phillips-University of Marburg, Marburg, Germany and McGill University, Montreal, Quebec, Canada. Electronic address: aust@staff.uni-marburg.de.
authors.forename: Hansjörg
authors.initials: H
authors.lastname: Aust
authors.affiliation: Phillips-University of Marburg, Marburg, Germany and McGill University, Montreal, Quebec, Canada.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Dinges
authors.affiliation: Phillips-University of Marburg, Marburg, Germany and McGill University, Montreal, Quebec, Canada.
authors.forename: Stefan
authors.initials: S
authors.lastname: Nardi-Hiebl
authors.affiliation: Phillips-University of Marburg, Marburg, Germany and McGill University, Montreal, Quebec, Canada.
authors.forename: Thilo
authors.initials: T
authors.lastname: Koch
authors.affiliation: Phillips-University of Marburg, Marburg, Germany and McGill University, Montreal, Quebec, Canada.
authors.forename: Ralph
authors.initials: R
authors.lastname: Lattermann
authors.affiliation: Phillips-University of Marburg, Marburg, Germany and McGill University, Montreal, Quebec, Canada.
authors.forename: Thomas
authors.initials: T
authors.lastname: Schricker
authors.affiliation: Phillips-University of Marburg, Marburg, Germany and McGill University, Montreal, Quebec, Canada.
authors.forename: Leopold H J
authors.initials: LH
authors.lastname: Eberhart
mesh_terms: D000368:Aged; D001774:Blood Chemical Analysis / Q000379:methods / Q000592:standards; D001786:Blood Glucose / Q000378:metabolism*; D001026:Coronary Artery Bypass / Q000379:methods / Q000592:standards*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D016343:Monitoring, Intraoperative / Q000379:methods / Q000592:standards*; D010865:Pilot Projects; D040521:Subcutaneous Tissue / Q000098:blood supply / Q000378:metabolism
chemical_list: D001786:Blood Glucose
keywords: CABG surgery; cardiopulmonary bypass; continuous monitor; glucose monitoring; hyperglycemia; hypothermic extracorporeal circulation