title: Automatic multigenic family annotation: risks and solutions.
abstract: A major challenge facing bioinformatics today is the efficient annotation of the exponential flow of genomic data. This has led to an increasing dependence on automatic annotation procedures, despite the relatively high error rates of these programs, particularly for multigenic families. We discuss here the errors and biases introduced by automatic genome annotations, focusing on issues with structural annotations of gene families, and suggest ways to overcome these limitations.
authors.affiliation: Université de Toulouse, UPS, UMR 5546, Laboratoire de Recherche en Sciences Végétales, BP 42617, F-31326 Castanet-Tolosan, France; CNRS, UMR 5546, BP 42617, F-31326 Castanet-Tolosan, France.
authors.forename: Nizar
authors.initials: N
authors.lastname: Fawal
authors.affiliation: Université de Toulouse, UPS, UMR 5546, Laboratoire de Recherche en Sciences Végétales, BP 42617, F-31326 Castanet-Tolosan, France; CNRS, UMR 5546, BP 42617, F-31326 Castanet-Tolosan, France.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.affiliation: Université de Toulouse, UPS, UMR 5546, Laboratoire de Recherche en Sciences Végétales, BP 42617, F-31326 Castanet-Tolosan, France; CNRS, UMR 5546, BP 42617, F-31326 Castanet-Tolosan, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Mathé
authors.affiliation: Université de Toulouse, UPS, UMR 5546, Laboratoire de Recherche en Sciences Végétales, BP 42617, F-31326 Castanet-Tolosan, France; CNRS, UMR 5546, BP 42617, F-31326 Castanet-Tolosan, France. Electronic address: dunand@lrsv.ups-tlse.fr.
authors.forename: Christophe
authors.initials: C
authors.lastname: Dunand
mesh_terms: D000818:Animals; D001331:Automation; D019295:Computational Biology; D030541:Databases, Genetic; D016678:Genome; D006801:Humans; D058977:Molecular Sequence Annotation; D005810:Multigene Family