title: Uncovering the PI3Ksome: phosphoinositide 3-kinases and counteracting PTEN form a signaling complex with intrinsic regulatory properties.
abstract: Production of the phosphoinositide lipid phosphatidylinositol (3,4,5)trisphosphate [PI(3,4,5)P3, or PIP3] by class I phosphoinositide 3-kinases (PI3Ks) is a major signaling mechanism whose deregulation contributes to serious diseases, including cancer. New findings suggest that tyrosine kinase receptor engagement results in the assembly of hetero-oligomeric PI3K complexes in which PI3Kα first activates PI3Kβ, and PI3K catalytic activity then promotes recruitment and activation of the PIP3-removing tumor suppressor PTEN. Thus, PIP3 production is fine-tuned through formation of an intrinsically regulated "PI3Ksome."
authors.affiliation: Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.
authors.forename: Claire
authors.initials: C
authors.lastname: Conche
authors.affiliation: Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California, USA ksauer@scripps.edu.
authors.forename: Karsten
authors.initials: K
authors.lastname: Sauer
mesh_terms: D020134:Catalytic Domain; D058534:Class I Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D051059:PTEN Phosphohydrolase / Q000378:metabolism*; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D018129:Phosphatidylinositol Phosphates; D058534:Class I Phosphatidylinositol 3-Kinases; D051059:PTEN Phosphohydrolase