title: In vivo inflammatory effects of ceria nanoparticles on CD-1 mouse: evaluation by hematological, histological, and TEM analysis.
abstract: The attention on CeO2-NPs environmental and in vivo effects is due to their presence in diesel exhaust and in diesel filters that release a more water-soluble form of ceria NPs, as well as to their use for medical applications. In this work, acute and subacute in vivo toxicity assays demonstrate no lethal effect of these NPs. Anyhow, performing in vivo evaluations on CD-1 mouse systems, we demonstrate that it is even not correct to assert that ceria NPs are harmless for living systems as they can induce status of inflammation, revealed by hematological-chemical-clinical assays as well as histological and TEM microscope observations. TEM analysis showed the presence of NPs in alveolar macrophages. Histological evaluation demonstrated the NPs presence in lungs tissues and this can be explained by assuming their ability to go into the blood stream and lately into the organs (generating inflammation).
authors.affiliation: Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Poma
authors.affiliation: Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Ragnelli
authors.affiliation: Unitat de Toxicologia Experimental y Ecotoxicologia (UTOX), Parc Cientific de Barcelona, 08028 Barcelona, Spain.
authors.forename: Joaquin
authors.initials: J
authors.lastname: de Lapuente
authors.affiliation: Unitat de Toxicologia Experimental y Ecotoxicologia (UTOX), Parc Cientific de Barcelona, 08028 Barcelona, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Ramos
authors.affiliation: Unitat de Toxicologia Experimental y Ecotoxicologia (UTOX), Parc Cientific de Barcelona, 08028 Barcelona, Spain.
authors.forename: Miquel
authors.initials: M
authors.lastname: Borras
authors.affiliation: Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
authors.forename: Pierpaolo
authors.identifier: 0000-0002-6409-2317
authors.initials: P
authors.lastname: Aimola
authors.affiliation: Immunotoxicology and Allergy Unit, Ageing Research Center, University Foundation, Department of Medicine and Science of Ageing, University "D'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Di Gioacchino
authors.affiliation: Department of Physical and Chemical Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
authors.forename: Sandro
authors.initials: S
authors.lastname: Santucci
authors.affiliation: Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: De Marzi
mesh_terms: D000818:Animals; D001774:Blood Chemical Analysis; D002563:Cerium / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity*; D004909:Erythrocyte Indices; D005260:Female; D007249:Inflammation / Q000097:blood / Q000139:chemically induced* / Q000473:pathology; D007668:Kidney / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D008099:Liver / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D008168:Lung / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D008264:Macrophages / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D053768:Metal Nanoparticles / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity* / Q000648:ultrastructure; D051379:Mice; D010581:Peyer's Patches / Q000187:drug effects / Q000473:pathology; D018675:Toxicity Tests / Q000379:methods; D014116:Toxicology
chemical_list: D002563:Cerium; C030583:ceric oxide