title: Comparison of serum anti-Müllerian hormone levels in normal weight and overweight-obese adolescent patients with polycystic ovary syndrome.
abstract: OBJECTIVE
  To evaluate serum concentration of anti-Müllerian hormone (AMH) in adolescent patients with polycystic ovary syndrome (PCOS) with respect to body mass index (BMI), and to investigate the relationship with clinical, metabolic and hormonal parameters.
  
  
  METHODS
  Fifty-eight adolescent girls (29 normal weight and 29 overweight-obese) diagnosed with PCOS and 28 apparently healthy girls (controls) were enrolled in the study. BMI was calculated in all cases. Serum AMH, hormonal and metabolic parameters were compared between patients with PCOS (normal weight and overweight-obese) and controls.
  
  
  RESULTS
  Serum AMH did not differ between patients with PCOS and controls (p=0.283), and no correlation was found between BMI and AMH. A significant positive correlation was found between 2-h plasma glucose on 75-g oral glucose tolerance test and AMH (R=0.364, p=0.005). HOMA-IR index and insulin were significantly higher in overweight-obese patients with PCOS than in controls, but no significant difference was found between controls and normal-weight patients with PCOS.
  
  
  CONCLUSIONS
  AMH was not found to be a reliable predictor for the presence of PCOS, and serum AMH did not differ between obese and non-obese adolescent patients with PCOS.
authors.affiliation: Bakirkoy Dr. Sadi Konuk Teaching and Research Hospital, Istanbul, Turkey. Electronic address: obstetrik@gmail.com.
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Cengiz
authors.affiliation: Bakirkoy Dr. Sadi Konuk Teaching and Research Hospital, Istanbul, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Ekin
authors.affiliation: Bakirkoy Dr. Sadi Konuk Teaching and Research Hospital, Istanbul, Turkey.
authors.forename: Hediye
authors.initials: H
authors.lastname: Dagdeviren
authors.affiliation: Bakirkoy Dr. Sadi Konuk Teaching and Research Hospital, Istanbul, Turkey.
authors.forename: Şükrü
authors.initials: Ş
authors.lastname: Yildiz
authors.affiliation: Bakirkoy Dr. Sadi Konuk Teaching and Research Hospital, Istanbul, Turkey.
authors.forename: Cihan
authors.initials: C
authors.lastname: Kaya
authors.affiliation: Bakirkoy Dr. Sadi Konuk Teaching and Research Hospital, Istanbul, Turkey.
authors.forename: Ammar
authors.initials: A
authors.lastname: Kanawati
mesh_terms: D000293:Adolescent; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D009765:Obesity / Q000097:blood* / Q000150:complications; D006080:Ovarian Follicle / Q000000981:diagnostic imaging; D050177:Overweight / Q000097:blood / Q000150:complications; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging; D011446:Prospective Studies; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D054304:Anti-Mullerian Hormone
keywords: AMH; Adolescent; Insulin resistance (HOMA-IR); Obese; Overweight; PCOS