title: Bioprosthetic mitral valve thrombosis complicating antiphospholipid antibody syndrome, successfully treated with thrombolysis.
abstract: The incidence of bioprosthetic valve thrombosis and related embolic complications is extremely rare, obviating the need for long-term anticoagulation. As a result, experience in the diagnosis and treatment of bioprosthetic valve thrombosis is fairly limited. We report the first case of antiphospholipid antibody syndrome presenting as bioprosthetic mitral valve thrombosis, 15 months after valve replacement, and successfully treated with thrombolytic therapy.
authors.affiliation: Department of Cardiovascular Medicine, University of Nebraska Medical Center, Omaha, Nebraska.
authors.forename: Mohammed A
authors.initials: MA
authors.lastname: Chamsi-Pasha
authors.forename: Tareq
authors.initials: T
authors.lastname: Alyousef
authors.forename: Samer
authors.initials: S
authors.lastname: Sayyed
mesh_terms: D000368:Aged; D016736:Antiphospholipid Syndrome / Q000150:complications*; D001705:Bioprosthesis; D004452:Echocardiography / Q000379:methods; D017548:Echocardiography, Transesophageal / Q000379:methods; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006350:Heart Valve Prosthesis; D006801:Humans; D008943:Mitral Valve / Q000000981:diagnostic imaging; D000077785:Tenecteplase; D015912:Thrombolytic Therapy / Q000379:methods*; D013927:Thrombosis / Q000150:complications* / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator; D000077785:Tenecteplase
keywords: anticoagulation; antiphospholipid antibody syndrome; bioprosthetic valve thrombosis; thrombolytics