title: Novel roles of the CCR4-NOT complex.
abstract: The CCR4-NOT complex is a multi-subunit protein complex evolutionarily conserved across eukaryotes which regulates several aspects of gene expression. A fascinating model is emerging in which this complex acts as a regulation platform, controlling gene products 'from birth to death' through the coordination of different cellular machineries involved in diverse cellular functions. Recently the CCR4-NOT functions have been extended to the control of the innate immune response through the regulation of interferon signaling. Thus, a more comprehensive picture of how CCR4-NOT allows the rapid adaptation of cells to external stress, from transcription to mRNA and protein decay, is presented and discussed here. Overall, CCR4-NOT permits the efficient and rapid adaptation of cellular gene expression in response to changes in environmental conditions and stimuli.
authors.affiliation: Université Lyon 1, Lyon, France; CNRS UMR 5286, Lyon, France; Inserm U1052, Lyon, France; Cancer Research Center of Lyon, Centre Léon Bérard, Lyon, France.
authors.forename: Clément
authors.initials: C
authors.lastname: Chapat
authors.forename: Laura
authors.initials: L
authors.lastname: Corbo
mesh_terms: D000222:Adaptation, Physiological; D056890:Eukaryota / Q000235:genetics / Q000502:physiology*; D005786:Gene Expression Regulation; D009097:Multienzyme Complexes / Q000378:metabolism; D012260:Ribonucleases / Q000378:metabolism*; D013312:Stress, Physiological; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D009097:Multienzyme Complexes; D014157:Transcription Factors; D012260:Ribonucleases