title: The role of microRNAs in the diagnosis and treatment of malignant pleural mesothelioma--a short review.
abstract: MicroRNAs are a class of small, non-coding RNAs that can function as tumor suppressors or oncogenes by regulating gene expression. This link was first reported in 2004, and has since been tied to a variety of malignancies, including malignant pleural mesothelioma (MPM). MPM is a malignancy arising in the mesothelial cells lining the lung pleura and is associated with chronic asbestos exposure. Despite the possibility for observing declining localized occurrence, global MPM is predicted to remain constant or increase slightly over the next decade. Global occurrence in combination with poor overall survival, difficulty in diagnosis, and limited effective treatment options signal the need for further exploration of miRNA involvement in MPM. Accordingly, this review highlights miRNA profiles associated with the diagnosis, prognosis, and therapeutic approaches in MPM.
authors.affiliation: 445 N. Fifth St. Phoenix, AZ 85004.
authors.forename: Kelly W
authors.initials: KW
authors.lastname: Sheff
authors.forename: Mir A
authors.initials: MA
authors.lastname: Hoda
authors.forename: Balazs
authors.initials: B
authors.lastname: Dome
authors.forename: Balazs
authors.initials: B
authors.lastname: Hegedus
authors.forename: Walter
authors.initials: W
authors.lastname: Klepetko
authors.forename: Glen J
authors.initials: GJ
authors.lastname: Weiss
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D008654:Mesothelioma / Q000175:diagnosis* / Q000628:therapy*; D000086002:Mesothelioma, Malignant; D035683:MicroRNAs / Q000235:genetics* / Q000627:therapeutic use*; D010997:Pleural Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D011379:Prognosis; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D035683:MicroRNAs