title: Engineering enzyme-cleavable hybrid click capsules with a pH-sheddable coating for intracellular degradation.
abstract: The engineering of layer-by-layer (LbL) hybrid click capsules that are responsive to biological stimuli is reported. The capsules comprise a pH-sheddable, non cross-linked outer coating that protects enzyme-cleavable inner layers. Upon cellular uptake, the outer coating is released and the capsules are enzymatically degraded. In vitro cell degradation results in rapid capsule degradation (10 min) upon cellular internalization.
authors.affiliation: Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria, 3010, Australia.
authors.forename: Sylvia T
authors.initials: ST
authors.lastname: Gunawan
authors.forename: Kang
authors.initials: K
authors.lastname: Liang
authors.forename: Georgina K
authors.initials: GK
authors.lastname: Such
authors.forename: Angus P R
authors.initials: AP
authors.lastname: Johnston
authors.forename: Melissa K M
authors.initials: MK
authors.lastname: Leung
authors.forename: Jiwei
authors.initials: J
authors.lastname: Cui
authors.forename: Frank
authors.initials: F
authors.lastname: Caruso
mesh_terms: D002214:Capsules; D057930:Click Chemistry; D004798:Enzymes / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D046529:Microscopy, Electron, Transmission; D011108:Polymers / Q000737:chemistry
chemical_list: D002214:Capsules; D004798:Enzymes; D011108:Polymers
keywords: click chemistry; enzyme-responsive; layer-by-layer (LbL); nanotechnology; polymer capsules