title: We are ageing.
abstract: Ageing and longevity is unquestioningly complex. Several thoughts and mechanisms of ageing such as pathways involved in oxidative stress, lipid and glucose metabolism, inflammation, DNA damage and repair, growth hormone axis and insulin-like growth factor (GH/IGF), and environmental exposure have been proposed. Also, some theories of ageing were introduced. To date, the most promising leads for longevity are caloric restriction, particularly target of rapamycin (TOR), sirtuins, hexarelin and hormetic responses. This review is an attempt to analyze the mechanisms and theories of ageing and achieving longevity.
authors.affiliation: Cardiology Department, Onassis Cardiac Surgery Center, 356 Sygrou Avenue, 17674 Athens, Greece.
authors.forename: Genovefa D
authors.initials: GD
authors.lastname: Kolovou
authors.affiliation: Cardiology Department, Onassis Cardiac Surgery Center, 356 Sygrou Avenue, 17674 Athens, Greece.
authors.forename: Vana
authors.initials: V
authors.lastname: Kolovou
authors.affiliation: Cardiology Department, Onassis Cardiac Surgery Center, 356 Sygrou Avenue, 17674 Athens, Greece.
authors.forename: Sophie
authors.initials: S
authors.lastname: Mavrogeni
mesh_terms: D000375:Aging / Q000235:genetics* / Q000473:pathology; D031204:Caloric Restriction; D004249:DNA Damage / Q000235:genetics; D004781:Environmental Exposure; D013006:Growth Hormone / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism; D008136:Longevity / Q000235:genetics*; D018384:Oxidative Stress / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics; D013002:Somatomedins / Q000378:metabolism
chemical_list: D007328:Insulin; D013002:Somatomedins; D013006:Growth Hormone