title: Serum lactate dehydrogenase in combination with free-to-total serum prostate specific antigen ratio for diagnosis of prostate cancer.
abstract: BACKGROUND
  Evaluate the utility of serum lactate dehydrogenase (LDH) in combination with free-to-total serum prostate specific antigen ratio (%fPSA), for diagnosis of prostate cancer (PC) with serum total prostate specific antigen (PSA) levels in the intermediate range of 4 to 10 ng/mL.
  
  
  METHODS
  The following variables were analysed: PSA, %fPSA, and LDH. Two categories of patients were included in the analysis: NOT PC and PC.
  
  
  RESULTS
  We studied 134 patients, 112 had NOT PC and 22 had PC. We defined the following multivariable score (S): S = A + B, where A and B are coefficients of LDH and %fPSA, respectively. AUC values were 0.719 (p = 0.0036), 0.749 (p = 0.0082), and 0.816 (p = 0.0001) for %fPSA, LDH, and S, respectively. Using the proposed S increases by 18% specificity compared to only using the %fPSA parameter.
  
  
  CONCLUSIONS
  LDH in combination with %fPSA improves diagnostic performance for detection of PC compared to using only %fPSA.
authors.forename: Jose Diego
authors.initials: JD
authors.lastname: Santotoribio
authors.forename: Consuelo
authors.initials: C
authors.lastname: Cañavate-Solano
authors.forename: Angela
authors.initials: A
authors.lastname: Garcia-de la Torre
authors.forename: Francisco
authors.initials: F
authors.lastname: Arce-Matute
authors.forename: Santiago
authors.initials: S
authors.lastname: Perez-Ramos
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D014408:Biomarkers, Tumor / Q000097:blood*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood* / Q000175:diagnosis*; D012372:ROC Curve
chemical_list: D014408:Biomarkers, Tumor; D007770:L-Lactate Dehydrogenase; D017430:Prostate-Specific Antigen