title: Evaluation of eight plasma proteins as candidate blood-based biomarkers for malignant gliomas.
abstract: Eight brain-derived proteins were evaluated regarding their potential for further development as a blood-based biomarker for malignant gliomas. Plasma levels for glial fibrillary acidic protein, neurogranin, brain-derived neurotrophic factor, intracellular adhesion molecule 5, metallothionein-3, beta-synuclein, S100 and neuron specific enolase were tested in plasma of 23 patients with high-grade gliomas (WHO grade IV), 11 low-grade gliomas (WHO grade II), and 15 healthy subjects. Compared to the healthy controls, none of the proteins appeared to be specific for glioblastomas. However, the data are suggestive of higher protein levels in gliosarcomas (n = 2), which may deserve further exploration.
authors.affiliation: The Johns Hopkins University, School of Medicine, Departments of1 Pediatrics2 Emergency Medicine3 Neurosurgery,4 and Oncology,5 Baltimore, MD, USA; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins , Baltimore, MD , USA 6.
authors.forename: Ryan P
authors.initials: RP
authors.lastname: Lange
authors.forename: Allen
authors.initials: A
authors.lastname: Everett
authors.forename: Pratima
authors.initials: P
authors.lastname: Dulloor
authors.forename: Frederick K
authors.initials: FK
authors.lastname: Korley
authors.forename: Chetan
authors.initials: C
authors.lastname: Bettegowda
authors.forename: Cherie
authors.initials: C
authors.lastname: Blair
authors.forename: Stuart A
authors.initials: SA
authors.lastname: Grossman
authors.forename: Matthias
authors.initials: M
authors.lastname: Holdhoff
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D001798:Blood Proteins / Q000378:metabolism*; D001932:Brain Neoplasms / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005910:Glioma / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D001798:Blood Proteins
keywords: Brain Tumors; Cancer Biomarkers; Circulating Biomarkers; Glioma; Proteins