title: Type I and type II Fc receptors regulate innate and adaptive immunity.
abstract: Antibodies produced in response to a foreign antigen are characterized by polyclonality, not only in the diverse epitopes to which their variable domains bind but also in the various effector molecules to which their constant regions (Fc domains) engage. Thus, the antibody's Fc domain mediates diverse effector activities by engaging two distinct classes of Fc receptors (type I and type II) on the basis of the two dominant conformational states that the Fc domain may adopt. These conformational states are regulated by the differences among antibody subclasses in their amino acid sequence and by the complex, biantennary Fc-associated N-linked glycan. Here we discuss the diverse downstream proinflammatory, anti-inflammatory and immunomodulatory consequences of the engagement of type I and type II Fc receptors in the context of infectious, autoimmune, and neoplastic disorders.
authors.affiliation: 1] The Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, New York, USA. [2].
authors.forename: Andrew
authors.initials: A
authors.lastname: Pincetic
authors.affiliation: 1] The Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, New York, USA. [2].
authors.forename: Stylianos
authors.initials: S
authors.lastname: Bournazos
authors.affiliation: 1] The Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, New York, USA. [2].
authors.forename: David J
authors.initials: DJ
authors.lastname: DiLillo
authors.affiliation: The Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, New York, USA.
authors.forename: Jad
authors.initials: J
authors.lastname: Maamary
authors.affiliation: The Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, New York, USA.
authors.forename: Taia T
authors.initials: TT
authors.lastname: Wang
authors.affiliation: The Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, New York, USA.
authors.forename: Rony
authors.initials: R
authors.lastname: Dahan
authors.affiliation: The Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, New York, USA.
authors.forename: Benjamin-Maximillian
authors.initials: BM
authors.lastname: Fiebiger
authors.affiliation: The Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, New York, USA.
authors.forename: Jeffrey V
authors.initials: JV
authors.lastname: Ravetch
mesh_terms: D056704:Adaptive Immunity; D000595:Amino Acid Sequence; D000906:Antibodies / Q000276:immunology; D017951:Antigen Presentation / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology; D006031:Glycosylation; D006801:Humans; D007113:Immunity, Innate; D007141:Immunoglobulin Fc Fragments / Q000737:chemistry / Q000145:classification / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology; D009369:Neoplasms / Q000276:immunology; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D017452:Receptors, IgG / Q000737:chemistry / Q000145:classification / Q000276:immunology*; D014611:Vaccination
chemical_list: D000906:Antibodies; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; D017452:Receptors, IgG