title: Novel biocompatible pH-stimuli responsive superparamagnetic hybrid hollow microspheres as tumor-specific drug delivery system.
abstract: Novel biocompatible pH-stimuli responsive superparamagnetic hybrid hollow microspheres have been designed via the layer-by-layer (LbL) self-assembly technique via the electrostatic interaction between the poly(ethylene glycol) grafted chitosan (CS-g-PEG) as polycation and the citrate modified ferroferric oxide nanoparticles (Fe3O4-CA) as hybrid anion onto the uniform polystyrene sulfonate (PSS) microsphere templates. The well-defined hybrid hollow microspheres ((CS-g-PEG/Fe3O4-CA)4/CS-g-PEG) were obtained after etching the templates by washing with DMF. They possessed superparamagnetic characteristics with a saturation magnetization of 37.23emu/g, and exhibited excellent stability in high ion-strength media and pH dependent DOX release. Their unique structure and outstanding performance make them potential platform for tumor-specific delivery in the tumor diagnostic and therapy.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry and Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
authors.forename: Xiaorui
authors.initials: X
authors.lastname: Li
authors.affiliation: State Key Laboratory of Applied Organic Chemistry and Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Du
authors.affiliation: State Key Laboratory of Applied Organic Chemistry and Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China. Electronic address: pliu@lzu.edu.cn.
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001672:Biocompatible Materials; D016503:Drug Delivery Systems; D006863:Hydrogen-Ion Concentration; D046529:Microscopy, Electron, Transmission; D008863:Microspheres; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D001672:Biocompatible Materials
keywords: Drug delivery system; Hollow microspheres; LbL self-assembly; Superparamagnetic; pH dependent release