title: 3-dimensional (3D) fabricated polymer based drug delivery systems.
abstract: Drug delivery from 3-dimensional (3D) structures is a rapidly growing area of research. It is essential to achieve structures wherein drug stability is ensured, the drug loading capacity is appropriate and the desired controlled release profile can be attained. Attention must also be paid to the development of appropriate fabrication machinery that allows 3D drug delivery systems (DDS) to be produced in a simple, reliable and reproducible manner. The range of fabrication methods currently being used to form 3D DDSs include electrospinning (solution and melt), wet-spinning and printing (3-dimensional). The use of these techniques enables production of DDSs from the macro-scale down to the nano-scale. This article reviews progress in these fabrication techniques to form DDSs that possess desirable drug delivery kinetics for a wide range of applications.
authors.affiliation: ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute, Australia; University of Wollongong, Wollongong, NSW 2522, Australia. Electronic address: smoulton@uow.edu.au.
authors.forename: Simon E
authors.initials: SE
authors.lastname: Moulton
authors.affiliation: ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute, Australia; University of Wollongong, Wollongong, NSW 2522, Australia. Electronic address: gwallace@uow.edu.au.
authors.forename: Gordon G
authors.initials: GG
authors.lastname: Wallace
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D011108:Polymers / Q000737:chemistry*; D066330:Printing, Three-Dimensional; D013499:Surface Properties; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D011108:Polymers
keywords: 3-Dimensional fabrication; Composites; Degradable polymer; Inks; Spatial distribution