title: NIR-triggered drug release from switchable rotaxane-functionalized silica-covered Au nanorods.
abstract: An NIR-triggered drug delivery system was developed by capping photo-switchable azobenzene-based rotaxane onto Au nanorod-mesoporous silica core-shell hybrids. Drug release from the nanocarrier in zebrafish embryo models could be controlled remotely under NIR irradiation, showing significant drug spreading to the adjacent tissues.
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore. zhaoyanli@ntu.edu.sg.
authors.forename: Menghuan
authors.initials: M
authors.lastname: Li
authors.forename: Hong
authors.initials: H
authors.lastname: Yan
authors.forename: Cathleen
authors.initials: C
authors.lastname: Teh
authors.forename: Vladimir
authors.initials: V
authors.lastname: Korzh
authors.forename: Yanli
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000818:Animals; D001391:Azo Compounds / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000295:instrumentation*; D065546:Drug Liberation; D006046:Gold / Q000737:chemistry*; D007259:Infrared Rays; D043942:Nanotubes / Q000737:chemistry*; D043862:Rotaxanes / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D015027:Zebrafish / Q000196:embryology
chemical_list: D001391:Azo Compounds; D003692:Delayed-Action Preparations; D043862:Rotaxanes; D006046:Gold; D012822:Silicon Dioxide; C009850:azobenzene