title: Visual displays that directly interface and provide read-outs of molecular states via molecular graphics processing units.
abstract: The monitoring of molecular systems usually requires sophisticated technologies to interpret nanoscale events into electronic-decipherable signals. We demonstrate a new method for obtaining read-outs of molecular states that uses graphics processing units made from molecular circuits. Because they are made from molecules, the units are able to directly interact with molecular systems. We developed deoxyribozyme-based graphics processing units able to monitor nucleic acids and output alphanumerical read-outs via a fluorescent display. Using this design we created a molecular 7-segment display, a molecular calculator able to add and multiply small numbers, and a molecular automaton able to diagnose Ebola and Marburg virus sequences. These molecular graphics processing units provide insight for the construction of autonomous biosensing devices, and are essential components for the development of molecular computing platforms devoid of electronics.
authors.affiliation: Division of Experimental Therapeutics, Department of Medicine, Columbia University, 630 W 168th St, New York, NY 10032 (USA).
authors.forename: Julia E
authors.initials: JE
authors.lastname: Poje
authors.forename: Tamara
authors.initials: T
authors.lastname: Kastratovic
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Macdonald
authors.forename: Ana C
authors.initials: AC
authors.lastname: Guillermo
authors.forename: Steven E
authors.initials: SE
authors.lastname: Troetti
authors.forename: Omar J
authors.initials: OJ
authors.lastname: Jabado
authors.forename: M Leigh
authors.initials: ML
authors.lastname: Fanning
authors.forename: Darko
authors.initials: D
authors.lastname: Stefanovic
authors.forename: Joanne
authors.initials: J
authors.lastname: Macdonald
mesh_terms: D015374:Biosensing Techniques; D003196:Computer Graphics; D021881:DNA, Catalytic / Q000737:chemistry* / Q000378:metabolism; D004581:Electronics; D009696:Nucleic Acids / Q000032:analysis*
chemical_list: D021881:DNA, Catalytic; D009696:Nucleic Acids
keywords: DNA computing; biosensors; molecular automata; molecular devices; nanotechnology