title: Co-exposure to refractory ceramic fibres and asbestos and risk of pleural mesothelioma.
abstract: The aim of this study was to investigate the hypothesis of an increased risk of pleural mesothelioma due to co-exposure to asbestos and refractory ceramic fibres (RCF) compared to asbestos exposure alone. Males were selected from a French case-control study conducted in 1987-1993 and from the French National Mesothelioma Surveillance Program in 1998-2006. Two population controls were frequency matched to each case by year of birth. Complete job histories were collected and occupational asbestos and RCF exposures were assessed using job exposure matrices. The dose-response relationships for asbestos exposure were estimated from an unconditional logistic regression model in subjects exposed to asbestos only (group 1) and subjects exposed to both asbestos and RCF (group 2). A total of 988 cases and 1125 controls ever-exposed to asbestos were included. A dose-response relationship was observed in both groups but it was stronger in group 2. In comparison with subjects exposed at the minimum value of the cumulative index of exposure, the odds ratio was 2.6 (95% CI 1.9-3.4) for subjects exposed to 75 fibres · mL(-1) · year(-1) in group 1 increasing to 12.4 (95% CI 4.6-33.7) in group 2. Our results suggest that the pleural carcinogenic effect of occupational asbestos exposure may be modified by additional exposure to RCF.
authors.affiliation: Université Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique Equipe Sante Environnement, Bordeaux, France INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique Equipe Sante Environnement, Bordeaux, France Université Bordeaux, ISPED, Equipe Associée en Sante Travail, Bordeaux, France aude.lacourt@isped.u-bordeaux2.fr.
authors.forename: Aude
authors.initials: A
authors.lastname: Lacourt
authors.affiliation: Université Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique Equipe Sante Environnement, Bordeaux, France INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique Equipe Sante Environnement, Bordeaux, France Université Bordeaux, ISPED, Equipe Associée en Sante Travail, Bordeaux, France.
authors.forename: Mickael
authors.initials: M
authors.lastname: Rinaldo
authors.affiliation: Université Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique Equipe Sante Environnement, Bordeaux, France INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique Equipe Sante Environnement, Bordeaux, France Université Bordeaux, ISPED, Equipe Associée en Sante Travail, Bordeaux, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Gramond
authors.affiliation: Institut de Veille Sanitaire, Département Sante Travail, Equipe Associée en Sante Travail, Bordeaux, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Ducamp
authors.affiliation: Institut de Veille Sanitaire, Département Sante Travail, Saint Maurice, France.
authors.forename: Annabelle
authors.initials: A
authors.lastname: Gilg Soit Ilg
authors.affiliation: Institut de Veille Sanitaire, Département Sante Travail, Saint Maurice, France.
authors.forename: Marcel
authors.initials: M
authors.lastname: Goldberg
authors.affiliation: INSERM U955, Universite Paris-Est Creteil, Faculte de Medecine, Creteil, France Centre Hospitalier Intercommunal, Service de pneumologie et pathologie professionnelle, Creteil, France.
authors.forename: Jean Claude
authors.initials: JC
authors.lastname: Pairon
authors.affiliation: Université Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique Equipe Sante Environnement, Bordeaux, France INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique Equipe Sante Environnement, Bordeaux, France Université Bordeaux, ISPED, Equipe Associée en Sante Travail, Bordeaux, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Brochard
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001194:Asbestos / Q000009:adverse effects*; D016022:Case-Control Studies; D002516:Ceramics / Q000009:adverse effects*; D005602:France; D006801:Humans; D016015:Logistic Models; D008297:Male; D008654:Mesothelioma / Q000139:chemically induced* / Q000209:etiology; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced / Q000209:etiology; D016273:Occupational Exposure; D010997:Pleural Neoplasms / Q000139:chemically induced* / Q000209:etiology; D012042:Registries; D012307:Risk Factors; D013997:Time Factors
chemical_list: D001194:Asbestos