title: Standardization and quantification in FDG-PET/CT imaging for staging and restaging of malignant disease.
abstract: There is a growing interest in using quantification in FDG-PET/CT in oncology, especially for evaluating response to therapy. Complex full quantitative procedures with blood sampling and dynamic scanning have been clinically replaced by the use of standardized uptake value measurements that provide an index of regional tracer uptake normalized to the administered dose of FDG. Some approaches have been proposed for assessing quantitative metabolic response, such as EORTC and PERCIST criteria in solid tumors. When using standardized uptake value in clinical routine and multicenter trials, standardization of protocols and quality control procedures of instrumentation is required.
authors.affiliation: PET-Unit, Institut de Diagnòstic per la Imatge (IDI), Hospital Universitari de Bellvitge-IDIBELL, Av. Feixa Llarga, s/n, L'Hospitalet de Llobregat, Barcelona 08907, Spain. Electronic address: cgamez@bellvitgehospital.cat.
authors.forename: Cristina
authors.initials: C
authors.lastname: Gámez-Cenzano
authors.affiliation: Medical Physics Department, Institut Català d'Oncologia (ICO), Hospital Duran i Reynals-IDIBELL, Av Gran Via, 199-203, L'Hospitalet de Llobregat, Barcelona 08908, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Pino-Sorroche
mesh_terms: D002138:Calibration; D004868:Equipment Failure; D019788:Fluorodeoxyglucose F18; D006801:Humans; D019300:Medical Errors; D064847:Multimodal Imaging / Q000379:methods / Q000592:standards*; D009367:Neoplasm Staging; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D049268:Positron-Emission Tomography / Q000295:instrumentation / Q000379:methods / Q000592:standards*; D011786:Quality Control; D011874:Radiometry; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed / Q000379:methods / Q000592:standards*; D016896:Treatment Outcome
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: Cancer; FDG; PET/CT; Quality control; Quantification; SUV; Standardization