title: Sodium tungstate alleviates biomechanical properties of diabetic rat femur via modulation of oxidative stress.
abstract: Diabetes mellitus leads to bone disorders such as osteopenia and osteoporosis that can increase fracture risk. On the other hand, sodium tungstate is an inorganic compound which exerts anti-diabetic activity in experimental studies due to its suggested insulin-mimetic or antioxidant activity. Therefore this study was designed to investigate the effect of tungstate on bone quality in diabetic rat femurs. The rats were divided into four groups: Control (C), tungstate-treated control (C+Tung), diabetes (STZ-D) and tungstate-treated diabetes (STZ-D+Tung). Diabetes mellitus was induced by single injection of streptozotocin (50 mg/kg). The treated rats received 150 mg/kg/day of sodium tungstate for 12 weeks. Sodium tungstate achieved a little (17%) but significant reduction on blood glucose levels, while it didn't recover the reduced body weights of diabetic rats. In addition, impaired bone mechanical quality was reversed, despite the unchanged mineral density. Sodium tungstate administration significantly lowered the 2-thiobarbituric acid reactive substances and restored the activity of tissue antioxidant enzymes such as glutathione peroxidase, catalase and superoxide dismutase in diabetic rats. On the other hand, glutathione levels didn't change in either case. These findings indicate that tungstate can improve the reduced mechanical quality of diabetic rat femurs due probably to reduction of reactive oxygen species and modulation of antioxidant enzymes as well as reduction in blood glucose levels.
authors.affiliation: Department of Nutrition and Dietetics, School of Health, Akdeniz University, 07070, Antalya, Turkey.
authors.forename: Baris O
authors.initials: BO
authors.lastname: Donmez
authors.forename: Nihal
authors.initials: N
authors.lastname: Ozturk
authors.forename: Mehmet
authors.initials: M
authors.lastname: Sarikanat
authors.forename: Nurettin
authors.initials: N
authors.lastname: Oguz
authors.forename: Ramazan
authors.initials: R
authors.lastname: Sari
authors.forename: Semir
authors.initials: S
authors.lastname: Ozdemir
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001696:Biomechanical Phenomena / Q000187:drug effects; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D015519:Bone Density / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism* / Q000503:physiopathology; D005269:Femur / Q000187:drug effects* / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D055595:Mechanical Phenomena; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D017973:Tungsten Compounds / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D017973:Tungsten Compounds; C025399:sodium tungstate(VI)