title: Immobilized biocatalytic process development and potential application in membrane separation: a review.
abstract: Biocatalytic membrane reactors have been widely used in different industries including food, fine chemicals, biological, biomedical, pharmaceuticals, environmental treatment and so on. This article gives an overview of the different immobilized enzymatic processes and their advantages over the conventional chemical catalysts. The application of a membrane bioreactor (MBR) reduces the energy consumption, and system size, in line with process intensification. The performances of MBR are considerably influenced by substrate concentration, immobilized matrix material, types of immobilization and the type of reactor. Advantages of a membrane associated bioreactor over a free-enzyme biochemical reaction, and a packed bed reactor are, large surface area of immobilization matrix, reuse of enzymes, better product recovery along with heterogeneous reactions, and continuous operation of the reactor. The present research work highlights immobilization techniques, reactor setup, enzyme stability under immobilized conditions, the hydrodynamics of MBR, and its application, particularly, in the field of sugar, starch, drinks, milk, pharmaceutical industries and energy generation.
authors.affiliation: a Department of Chemical Engineering and Materials , University of Calabria , Cubo-42A, Via P. Bucci , Rende (CS) , Italy .|c Department of Chemical Engineering , Jadavpur University , Kolkata , West Bengal , India .|e Department of Informatics, Modeling, Electronics and Systems Engineering (D.I.M.E.S.) , University of Calabria , Via-P. Bucci , Rende (CS) , Italy , and.
authors.forename: Sudip
authors.initials: S
authors.lastname: Chakraborty
authors.affiliation: b Analytical Research Group , Insitut Teknologi Bandung , Indonesia .
authors.forename: Handajaya
authors.initials: H
authors.lastname: Rusli
authors.affiliation: c Department of Chemical Engineering , Jadavpur University , Kolkata , West Bengal , India .
authors.forename: Arijit
authors.initials: A
authors.lastname: Nath
authors.affiliation: d Department of Chemical Engineering , National Institute of Technology Durgapur , West Bengal , India .
authors.forename: Jaya
authors.initials: J
authors.lastname: Sikder
authors.affiliation: c Department of Chemical Engineering , Jadavpur University , Kolkata , West Bengal , India .
authors.forename: Chiranjib
authors.initials: C
authors.lastname: Bhattacharjee
authors.affiliation: e Department of Informatics, Modeling, Electronics and Systems Engineering (D.I.M.E.S.) , University of Calabria , Via-P. Bucci , Rende (CS) , Italy , and.
authors.forename: Stefano
authors.initials: S
authors.lastname: Curcio
authors.affiliation: a Department of Chemical Engineering and Materials , University of Calabria , Cubo-42A, Via P. Bucci , Rende (CS) , Italy .|f WCU Department of Energy Engineering , College of Engineering, Hanyang University , Seoul , Korea.
authors.forename: Enrico
authors.initials: E
authors.lastname: Drioli
mesh_terms: D055162:Biocatalysis; D019149:Bioreactors; D004800:Enzymes, Immobilized / Q000737:chemistry* / Q000378:metabolism; D006868:Hydrolysis; D008566:Membranes / Q000737:chemistry
chemical_list: D004800:Enzymes, Immobilized
keywords: Application; biocatalytic membrane reactor; enzyme immobilization; enzyme stability; hydrodynamic study