title: Stimuli-responsive hydrogels in drug delivery and tissue engineering.
abstract: Hydrogels are the three-dimensional network structures obtained from a class of synthetic or natural polymers which can absorb and retain a significant amount of water. Hydrogels are one of the most studied classes of polymer-based controlled drug release. These have attracted considerable attention in biochemical and biomedical fields because of their characteristics, such as swelling in aqueous medium, biocompatibility, pH and temperature sensitivity or sensitivity towards other stimuli, which can be utilized for their controlled zero-order release. The hydrogels are expected to explore new generation of self-regulated delivery system having a wide array of desirable properties. This review highlights the exciting opportunities and challenges in the area of hydrogels. Here, we review different literatures on stimuli-sensitive hydrogels, such as role of temperature, electric potential, pH and ionic strength to control the release of drug from hydrogels.
authors.affiliation: a Nanomedicine Research Centre , ISF College of Pharmacy Ferozepur , Moga , Punjab , India.
authors.forename: Nikhil
authors.initials: N
authors.lastname: Sood
authors.affiliation: a Nanomedicine Research Centre , ISF College of Pharmacy Ferozepur , Moga , Punjab , India.
authors.forename: Ankur
authors.initials: A
authors.lastname: Bhardwaj
authors.affiliation: a Nanomedicine Research Centre , ISF College of Pharmacy Ferozepur , Moga , Punjab , India.
authors.forename: Shuchi
authors.initials: S
authors.lastname: Mehta
authors.affiliation: a Nanomedicine Research Centre , ISF College of Pharmacy Ferozepur , Moga , Punjab , India.
authors.forename: Abhinav
authors.initials: A
authors.lastname: Mehta
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D011108:Polymers / Q000737:chemistry; D013696:Temperature; D023822:Tissue Engineering
chemical_list: D020100:Hydrogels; D011108:Polymers
keywords: Hydrogel; pH sensitivity; polymerization; scaffolds; stimuli; swelling