title: Combinatorial synthesis of functionalized spirooxindole-pyrrolidine/pyrrolizidine/pyrrolothiazole derivatives via three-component 1,3-dipolar cycloaddition reactions.
abstract: A series of diverse polycyclic heterocycles containing spirooxindole, pyridine/thiophene, and pyrrolidine/pyrrolizidine/pyrrolothiazole rings have been synthesized through the 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the condensation of dicarbonyl compounds (isatin or acenaphthenequinone) and secondary amino acids with dipolarophiles. The method is simple and provides diverse and biologically interesting products with excellent yields.
authors.affiliation: Department of Chemistry, School of Pharmacy, Xuzhou Medical College , Xuzhou, 221004, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Zhou
authors.initials: Z
authors.lastname: Xu
authors.forename: Songlei
authors.initials: S
authors.lastname: Zhu
mesh_terms: D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D011759:Pyrrolidines / Q000737:chemistry*; D011763:Pyrrolizidine Alkaloids / Q000737:chemistry*; D013141:Spiro Compounds / Q000737:chemistry*; D013844:Thiazoles / Q000737:chemistry*
chemical_list: D006571:Heterocyclic Compounds; D007211:Indoles; D011759:Pyrrolidines; D011763:Pyrrolizidine Alkaloids; D013141:Spiro Compounds; D013844:Thiazoles; C032519:pyrrolidine
keywords: 1,3-dipolar cycloaddition; combinatorial synthesis; pyrrolidine/pyrrolizidine/pyrrolothiazole; spirooxindole