title: Tumour necrosis factor superfamily members in the pathogenesis of inflammatory bowel disease.
abstract: Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the gastrointestinal tract of unclear aetiology of which two major forms are Crohn's disease (CD) and ulcerative colitis (UC). CD and UC are immunologically distinct, although they both result from hyperactivation of proinflammatory pathways in intestines and disruption of intestinal epithelial barrier. Members of the tumour necrosis factor superfamily (TNFSF) are molecules of broad spectrum of activity, including direct disruption of intestinal epithelial barrier integrity and costimulation of proinflammatory functions of lymphocytes. Tumour necrosis factor (TNF) has a well-established pathological role in IBD which also serves as a target in IBD treatment. In this review we discuss the role of TNF and other TNFSF members, notably, TL1A, FasL, LIGHT, TRAIL, and TWEAK, in the pathogenesis of IBD.
authors.affiliation: Department of Histology, Medical University of Gdańsk, Dębinki 1, 80-211 Gdańsk, Poland.
authors.forename: Tomasz J
authors.initials: TJ
authors.lastname: Ślebioda
authors.affiliation: Department of Histology, Medical University of Gdańsk, Dębinki 1, 80-211 Gdańsk, Poland.
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Kmieć
mesh_terms: D000818:Animals; D000074049:Cytokine TWEAK; D053222:Fas Ligand Protein / Q000378:metabolism; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000378:metabolism* / Q000473:pathology*; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000378:metabolism; D053326:Tumor Necrosis Factor Ligand Superfamily Member 14 / Q000378:metabolism; D053380:Tumor Necrosis Factor Ligand Superfamily Member 15 / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D048069:Tumor Necrosis Factors / Q000378:metabolism
chemical_list: D000074049:Cytokine TWEAK; D053222:Fas Ligand Protein; D053221:TNF-Related Apoptosis-Inducing Ligand; C109743:TNFSF12 protein, human; C117026:TNFSF15 protein, human; D053326:Tumor Necrosis Factor Ligand Superfamily Member 14; D053380:Tumor Necrosis Factor Ligand Superfamily Member 15; D014409:Tumor Necrosis Factor-alpha; D048069:Tumor Necrosis Factors