title: Dietary advanced glycation end products are associated with decline in memory in young elderly.
abstract: We recently reported that serum methylglyoxal (sMG) is associated with a faster rate of decline in a global measure of cognition in the very elderly. We here provide for the first time evidence in which high levels of dietary AGE (dAGE) are associated with faster rate of decline in memory in 49 initially non-demented young elderly (p=0.012 in mixed regression models adjusting for sociodemographic and cardiovascular factors). Since modifying the levels of AGEs in the diet may be relatively easy, these preliminary results suggest a simple strategy to diminish cognitive compromise in the elderly and warrant further investigation.
authors.affiliation: The Icahn School of Medicine at Mount Sinai, New York, NY, US. Electronic address: rebecca.west@mssm.edu.
authors.forename: Rebecca K
authors.initials: RK
authors.lastname: West
authors.affiliation: The Icahn School of Medicine at Mount Sinai, New York, NY, US.
authors.forename: Erin
authors.initials: E
authors.lastname: Moshier
authors.affiliation: The Sheba Medical Center, The Joseph Sagol Neuroscience Center, Ramat Gan, Israel.
authors.forename: Irit
authors.initials: I
authors.lastname: Lubitz
authors.affiliation: The Icahn School of Medicine at Mount Sinai, New York, NY, US.
authors.forename: James
authors.initials: J
authors.lastname: Schmeidler
authors.affiliation: The Icahn School of Medicine at Mount Sinai, New York, NY, US.
authors.forename: James
authors.initials: J
authors.lastname: Godbold
authors.affiliation: The Icahn School of Medicine at Mount Sinai, New York, NY, US.
authors.forename: Weijing
authors.initials: W
authors.lastname: Cai
authors.affiliation: The Icahn School of Medicine at Mount Sinai, New York, NY, US.
authors.forename: Jaime
authors.initials: J
authors.lastname: Uribarri
authors.affiliation: The Icahn School of Medicine at Mount Sinai, New York, NY, US.
authors.forename: Helen
authors.initials: H
authors.lastname: Vlassara
authors.affiliation: The Icahn School of Medicine at Mount Sinai, New York, NY, US; The James J Peters Veterans Affairs Medical Center, Bronx, NY, US.
authors.forename: Jeremy M
authors.initials: JM
authors.lastname: Silverman
authors.affiliation: The Icahn School of Medicine at Mount Sinai, New York, NY, US; The Sheba Medical Center, The Joseph Sagol Neuroscience Center, Ramat Gan, Israel.
authors.forename: Michal Schnaider
authors.initials: MS
authors.lastname: Beeri
mesh_terms: D000368:Aged; D003072:Cognition Disorders / Q000097:blood / Q000209:etiology; D004032:Diet / Q000009:adverse effects*; D005260:Female; D017127:Glycation End Products, Advanced / Q000009:adverse effects* / Q000097:blood; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000097:blood / Q000209:etiology*; D008875:Middle Aged; D011765:Pyruvaldehyde / Q000097:blood; D012044:Regression Analysis
chemical_list: D017127:Glycation End Products, Advanced; D011765:Pyruvaldehyde
keywords: Cognitive decline; Dietary advanced glycation end products; Memory; Methylglyoxal; Type 2 diabetes