title: Macromolecule loading into spherical, elliptical, star-like and cubic calcium carbonate carriers.
abstract: We fabricated calcium carbonate particles with spherical, elliptical, star-like and cubical morphologies by varying relative salt concentrations and adding ethylene glycol as a solvent to slow down the rate of particle formation. The loading capacity of particles of different isotropic (spherical and cubical) and anisotropic (elliptical and star-like) geometries is investigated, and the surface area of such carriers is analysed. Potential applications of such drug delivery carriers are highlighted.
authors.affiliation: BIOtech research center, Department of Physics, University of Trento via delle Regole 101, 38123 Mattarello (Italy), Fax: (+39) 0461 283659; Shubnikov Institute of Crystallography Russian Academy of Science, Leninskii prospekt 59, Moscow 119333 (Russia). bogdan.parakhonskiy@unitn.it.
authors.forename: Bogdan V
authors.initials: BV
authors.lastname: Parakhonskiy
authors.forename: Alexey M
authors.initials: AM
authors.lastname: Yashchenok
authors.forename: Senem
authors.initials: S
authors.lastname: Donatan
authors.forename: Dmitry V
authors.initials: DV
authors.lastname: Volodkin
authors.forename: Francesco
authors.initials: F
authors.lastname: Tessarolo
authors.forename: Renzo
authors.initials: R
authors.lastname: Antolini
authors.forename: Helmuth
authors.initials: H
authors.lastname: Möhwald
authors.forename: Andre G
authors.initials: AG
authors.lastname: Skirtach
mesh_terms: D002119:Calcium Carbonate / Q000138:chemical synthesis / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D016503:Drug Delivery Systems; D019855:Ethylene Glycol / Q000737:chemistry; D046911:Macromolecular Substances / Q000138:chemical synthesis / Q000737:chemistry; D010316:Particle Size; D013499:Surface Properties
chemical_list: D004337:Drug Carriers; D046911:Macromolecular Substances; D019855:Ethylene Glycol; D002119:Calcium Carbonate
keywords: adsorption; calcium; drug delivery; nanoparticles; solid-state structures