title: Segmental kidney volumes measured by dynamic contrast-enhanced magnetic resonance imaging and their association with CKD in older people.
abstract: BACKGROUND
  Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a potentially powerful tool for analysis of kidney structure and function. The ability to measure functional and hypofunctional tissues could provide important information in groups at risk for chronic kidney disease (CKD), such as the elderly.
  
  
  METHODS
  Observational study with a cross-sectional design.
  
  
  METHODS
  493 volunteers (aged 72-94 years; 278 women; mean estimated glomerular filtration rate [eGFR], 67±15mL/min/1.73m(2); 40% with CKD) in the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study.
  
  
  METHODS
  DCE-MRI kidney segmentation data.
  
  
  METHODS
  eGFR, urine albumin-creatinine ratio (ACR), and risk factors for and complications of CKD.
  
  
  RESULTS
  After adjustment for age, sex, and height, eGFR was related to kidney volume (ΔR²=0.19; P<0.001), cortex volume (ΔR²=0.14; P<0.001), medulla volume (ΔR²=0.18; P<0.001), and volume percentages of fibrosis (ΔR²=0.03; P<0.001) and fat (ΔR²=0.01; P=0.03). In similarly adjusted models, log(ACR) was related to kidney volume (ΔR²=0.02; P<0.001) and fibrosis volume percentage (ΔR²=0.03; P<0.001). Using multivariable regression models adjusted for eGFR, ACR, age, sex, and height, kidney volume was related positively to body mass index (B=29.9±2.1[SE]mL; P<0.001), smoking (B=19.7±7.7mL; P=0.01), and diabetes mellitus (B=14.8±7.1mL; P=0.04) and negatively to hematocrit (B=-4.4±2.1mL; P=0.04 [model R²=0.72; P<0.001]); relations were per 1-SD greater value of the variable. Fibrosis volume percentage was associated positively with body mass index (B=0.28±0.03; P<0.001), cardiac output (B=0.15±0.03; P<0.001), and heart rate (B=0.08±0.03; P=0.01) and negatively with hematocrit (B=-0.07±0.3; P=0.02) and augmentation index (B=-0.06±0.03; P=0.04 [model R²=0.49; P<0.001]); again, relations are per 1-SD greater value of the variable.
  
  
  CONCLUSIONS
  Automatic segmentations were not validated by histology. The limited age range prevented meaningful interpretation of age effects on measured data or the automatic segmentation procedure.
  
  
  CONCLUSIONS
  Kidney volume, cortex volume, and hypofunctional volume fraction assessed by DCE-MRI may provide information about CKD risk and prognosis beyond that provided by eGFR and urine ACR.
authors.affiliation: Cardiovascular Engineering Inc, Norwood, MA.
authors.forename: Todd
authors.initials: T
authors.lastname: Woodard
authors.affiliation: Icelandic Heart Association, Kopavogur, Iceland.
authors.forename: Sigurdur
authors.initials: S
authors.lastname: Sigurdsson
authors.affiliation: Cardiovascular Engineering Inc, Norwood, MA.
authors.forename: John D
authors.initials: JD
authors.lastname: Gotal
authors.affiliation: Cardiovascular Engineering Inc, Norwood, MA.
authors.forename: Alyssa A
authors.initials: AA
authors.lastname: Torjesen
authors.affiliation: Tufts Medical Center, Boston, MA.
authors.forename: Lesley A
authors.initials: LA
authors.lastname: Inker
authors.affiliation: Icelandic Heart Association, Kopavogur, Iceland; University of Iceland, Reykjavik, Iceland.
authors.forename: Thor
authors.initials: T
authors.lastname: Aspelund
authors.affiliation: Icelandic Heart Association, Kopavogur, Iceland.
authors.forename: Gudny
authors.initials: G
authors.lastname: Eiriksdottir
authors.affiliation: Icelandic Heart Association, Kopavogur, Iceland; University of Iceland, Reykjavik, Iceland.
authors.forename: Vilmundur
authors.initials: V
authors.lastname: Gudnason
authors.affiliation: National Institute on Aging, National Institutes of Health, Bethesda, MD.
authors.forename: Tamara B
authors.initials: TB
authors.lastname: Harris
authors.affiliation: National Institute on Aging, National Institutes of Health, Bethesda, MD.
authors.forename: Lenore J
authors.initials: LJ
authors.lastname: Launer
authors.affiliation: Tufts Medical Center, Boston, MA.
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Levey
authors.affiliation: Cardiovascular Engineering Inc, Norwood, MA. Electronic address: garyfmitchell@mindspring.com.
authors.forename: Gary F
authors.initials: GF
authors.lastname: Mitchell
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000419:Albuminuria / Q000175:diagnosis; D015992:Body Mass Index; D003404:Creatinine / Q000652:urine; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007089:Image Enhancement; D007668:Kidney / Q000473:pathology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009929:Organ Size; D011237:Predictive Value of Tests; D011379:Prognosis; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D012307:Risk Factors; D014481:United States / Q000453:epidemiology
chemical_list: D003404:Creatinine
keywords: Automatic segmentation; chronic kidney disease (CKD); dynamic contrast enhancement (DCE); fibrosis; hypofunctional tissue; kidney imaging; magnetic resonance imaging (MRI); segmental kidney volume