title: Alpha-theta border EEG abnormalities in preclinical Huntington's disease.
abstract: BACKGROUND
  Brain dysfunction precedes clinical manifestation of Huntington's disease (HD) by decades. This study was aimed to determine whether resting EEG is altered in preclinical HD mutations carriers (pre-HD).
  
  
  METHODS
  We examined relative power of broad traditional EEG bands as well as 1-Hz sub-bands of theta and alpha from the resting-state EEG of 29 pre-HD individuals and of 29 age-matched normal controls.
  
  
  RESULTS
  The relative power of the narrow sub-band in the border of theta-alpha (7-8 Hz) was significantly reduced in pre-HD subjects as compared to normal controls, while the alterations in relative power of the broad frequency bands were not significant. In pre-HD subjects, the number of CAG repeats in the huntingtin (HTT) gene as well as the disease burden score (DBS) showed a positive correlation with relative power of the delta and theta frequency bands and their sub-bands and a negative correlation with alpha band relative power and the differences of relative power of the 7-8 Hz and 4-5 Hz frequency sub-bands.
  
  
  CONCLUSIONS
  The obtained results suggest that EEG alterations in pre-HD individuals may be related to the course of the pathological process and to HD endophenotype. Analysis of the narrow EEG bands was found to be more useful for assessing EEG alterations in pre-HD individuals than a more traditional approach using broad bandwidths.
authors.affiliation: Department for Brain Research, Research Center of Neurology, Russian Academy of Medical Sciences, Moscow, Russia. Electronic address: ponomare@yandex.ru.
authors.forename: Natalya
authors.initials: N
authors.lastname: Ponomareva
authors.affiliation: Department of Neurogenetics, Research Center of Neurology, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: Sergey
authors.initials: S
authors.lastname: Klyushnikov
authors.affiliation: Department of Neurogenetics, Research Center of Neurology, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: Natalya
authors.initials: N
authors.lastname: Abramycheva
authors.affiliation: Department for Brain Research, Research Center of Neurology, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: Daria
authors.initials: D
authors.lastname: Malina
authors.affiliation: Department for Brain Research, Research Center of Neurology, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: Nadejda
authors.initials: N
authors.lastname: Scheglova
authors.affiliation: Department for Brain Research, Research Center of Neurology, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: Vitaly
authors.initials: V
authors.lastname: Fokin
authors.affiliation: Department of Neurogenetics, Research Center of Neurology, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: Irina
authors.initials: I
authors.lastname: Ivanova-Smolenskaia
authors.affiliation: Department for Brain Research, Research Center of Neurology, Russian Academy of Medical Sciences, Moscow, Russia; Department of Neurogenetics, Research Center of Neurology, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: Sergey
authors.initials: S
authors.lastname: Illarioshkin
mesh_terms: D000328:Adult; D000513:Alpha Rhythm / Q000235:genetics / Q000502:physiology*; D000704:Analysis of Variance; D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D004569:Electroencephalography; D005260:Female; D006801:Humans; D000071058:Huntingtin Protein; D006816:Huntington Disease / Q000235:genetics / Q000503:physiopathology*; D008297:Male; D009154:Mutation / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics; D009483:Neuropsychological Tests; D012720:Severity of Illness Index; D013223:Statistics as Topic; D013826:Theta Rhythm / Q000235:genetics / Q000502:physiology*; D018911:Trinucleotide Repeats / Q000235:genetics
chemical_list: C086055:HTT protein, human; D000071058:Huntingtin Protein; D009419:Nerve Tissue Proteins
keywords: CAG repeats; Cognitive functions; EEG; HTT gene; Huntington's disease; Preclinical stage