title: Optic nerve involvement of Waldenström's macroglobulinemia: with autopsy findings.
abstract: Waldenström's macroglobulinemia (WM) is an indolent chronic lymphoproliferative disorder within the spectrum of lymphoplasmacytic lymphoma (LPL), characterized by a proliferation of plasmacytoid lymphocytes and the production of monoclonal IgM. Although, peripheral neurologic complications commonly occurs due to hyperviscosity in WM, central nervous system (CNS) involvement is very rare. Herein, we present the case of a 67-year-old man who initially presented with progressive visual loss and was diagnosed as WM/LPL with a very aggressive clinical course. He underwent chemotherapy with high dose methotrexate (MTX) plus cytarabine (Ara-C). However, he died and findings of a subsequent autopsy revealed the presence of lymphoplasmacytoid cells in the optic nerve.
authors.affiliation: Department of Internal of Medicine, Mito Red Cross Hospital, Mito, Ibaraki, Japan, hiroko@a2.keio.jp.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Nishida
authors.forename: Risa
authors.initials: R
authors.lastname: Hashida
authors.forename: Mami
authors.initials: M
authors.lastname: Hatano
authors.forename: Masao
authors.initials: M
authors.lastname: Hori
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Obara
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001344:Autopsy; D001766:Blindness / Q000209:etiology / Q000473:pathology; D003561:Cytarabine / Q000008:administration & dosage; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D008214:Lymphocytes / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D009900:Optic Nerve / Q000473:pathology*; D011239:Prednisolone / Q000008:administration & dosage; D008258:Waldenstrom Macroglobulinemia / Q000188:drug therapy / Q000473:pathology*
chemical_list: D003561:Cytarabine; D011239:Prednisolone; D008727:Methotrexate