title: The perirhinal cortex.
abstract: Anatomically, the perirhinal cortex sits at the boundary between the medial temporal lobe and the ventral visual pathway. It has prominent interconnections not only with both these systems, but also with a wide range of unimodal and polymodal association areas. Consistent with these diverse projections, neurophysiological studies reveal a multidimensional set of mnemonic signals that include stimulus familiarity, within- and between-domain associations, associative recall, and delay-based persistence. This wide range of perirhinal memory signals not only includes signals that are largely unique to the perirhinal cortex (i.e., object familiarity), consistent with dual-process theories, but also includes a range of signals (i.e., associative flexibility and recall) that are strongly associated with the hippocampus, consistent with single-process theories. These neurophysiological findings have important implications for bridging the gap between single-process and dual-process models of medial temporal lobe function.
authors.affiliation: Center for Neural Science, New York University, New York, NY 10003; email: wendy@cns.nyu.edu.
authors.forename: Wendy A
authors.initials: WA
authors.lastname: Suzuki
authors.forename: Yuji
authors.initials: Y
authors.lastname: Naya
mesh_terms: D000679:Amygdala / Q000033:anatomy & histology / Q000502:physiology*; D000818:Animals; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000502:physiology*; D006801:Humans; D008568:Memory / Q000502:physiology*; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology; D013702:Temporal Lobe / Q000033:anatomy & histology* / Q000502:physiology*
keywords: association memory; declarative memory; medial temporal lobe