title: [Changes of mechanical pain threshold in rats with experimental autoimmune prostatitis].
abstract: OBJECTIVE
  To observe the changes of the mechanical pain threshold in the rat model of autoimmune prostatitis, explore the mechanism of autoimmune prostatitis pain and offer some animal experimental evidence for the drug therapy of the condition.
  
  
  METHODS
  Twenty male Wistar rats weighing 180 - 220 g were divided into a model and a control group. The autoimmune prostatitis model was established by subcutaneous injection of an extract of male rat prostate glands (RPG) at 60 mg/ml in Freund's complete adjuvant (FCA) and pertussis-diphtheria-tetanus vaccine at 0 and 30 days, respectively. Mechanical tactile hyperalgesia was measured once a week using Von Frey Filaments from the beginning of the study. At 8 weeks after modeling, the rats were sacrificed and the prostate tissues harvested for observation of histomorphological changes by HE staining.
  
  
  RESULTS
  HE staining revealed different degrees of benign prostatitis in the model rats. Compared with the controls, the mechanical pain threshold in the model rats was significantly decreased with the increased time of modeling, from (65.52 +/- 6.27) g at 0 week to (23.67 +/- 4.09) g at 8 weeks (P < 0.01). Statistically significant differences were found in the variation trend at different time points between the two groups (P < 0.01).
  
  
  CONCLUSIONS
  Autoimmune prostatitis models were successfully established in rats and hyperalgesia was induced after modeling.
authors.forename: Guo-Hong
authors.initials: GH
authors.lastname: Song
authors.forename: Tulahong
authors.initials: T
authors.lastname: Aisikaer
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: He
authors.forename: Saimaiti
authors.initials: S
authors.lastname: Julaiti
authors.forename: Qiu-Mei
authors.initials: QM
authors.lastname: Zhang
authors.forename: Wen-Yu
authors.initials: WY
authors.lastname: Li
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000503:physiopathology*; D004195:Disease Models, Animal; D008297:Male; D017288:Pain Threshold / Q000502:physiology*; D011472:Prostatitis / Q000276:immunology / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar