title: Mast cell leukemia: an extremely rare disease.
abstract: Systemic mastocytosis is characterized by pathologic proliferation and accumulation of mast cells in at least one extracutaneous organ such as liver, spleen, bone marrow, or lymph nodes. The clinical features are highly variable depending on impairment of the involved organ systems. It often raises diagnostic challenges. Here we report a case of a 78-year-old patient with mast cell leukemia. The literature is reviewed regarding the diagnosis and updated management of this rare disease.
authors.affiliation: Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
authors.forename: Dai-Yin
authors.initials: DY
authors.lastname: Lu
authors.affiliation: Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC. Electronic address: jpgau@vghtpe.gov.tw.
authors.forename: Jyh-Pyng
authors.initials: JP
authors.lastname: Gau
authors.affiliation: Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC.
authors.forename: Ying-Chung
authors.initials: YC
authors.lastname: Hong
authors.affiliation: Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC.
authors.forename: Chun-Yu
authors.initials: CY
authors.lastname: Liu
authors.affiliation: Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC.
authors.forename: Yuan-Bin
authors.initials: YB
authors.lastname: Yu
authors.affiliation: Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC.
authors.forename: Liang-Tsai
authors.initials: LT
authors.lastname: Hsiao
authors.affiliation: Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC.
authors.forename: Jin-Hwang
authors.initials: JH
authors.lastname: Liu
authors.affiliation: Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC.
authors.forename: Po-Min
authors.initials: PM
authors.lastname: Chen
authors.affiliation: Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC.
authors.forename: Tzeon-Jye
authors.initials: TJ
authors.lastname: Chiou
authors.affiliation: Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC.
authors.forename: Cheng-Hwai
authors.initials: CH
authors.lastname: Tzeng
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001549:Benzamides / Q000627:therapeutic use; D006801:Humans; D000068877:Imatinib Mesylate; D007946:Leukemia, Mast-Cell / Q000175:diagnosis* / Q000188:drug therapy*; D008297:Male; D010879:Piperazines / Q000627:therapeutic use; D011743:Pyrimidines / Q000627:therapeutic use; D019311:Staurosporine / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D019311:Staurosporine; C059539:midostaurin
keywords: KITD816V; interferon; systemic mastocytosis; tyrosine kinase inhibitor