title: Three new sesquiterpenoids from cultures of the basidiomycete Conocybe siliginea.
abstract: Three new sesquiterpenoids (1-3), along with four known compounds (4-7), were isolated from cultures of the fungus Conocybe siliginea. The structures of new compounds were elucidated using spectroscopic methods. The known compounds were identified by comparing their spectroscopic data with those reported in the literature. All new compounds were evaluated for cytotoxicity against five human cancer cell lines, but none of them possesses significant activity (IC50>40μM).
authors.affiliation: a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , P.R. China.
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Yang
authors.forename: Zheng-Hui
authors.initials: ZH
authors.lastname: Li
authors.forename: Ze-Jun
authors.initials: ZJ
authors.lastname: Dong
authors.forename: Tao
authors.initials: T
authors.lastname: Feng
authors.forename: Ji-Kai
authors.initials: JK
authors.lastname: Liu
mesh_terms: D001487:Basidiomycota / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C000596393:4alpha,11,12,14-tetrahydroxy-1-tremulene; C000596394:5-O-acetyl-7,14-dihydroxy-protoilludanol; C000596392:5alpha,11,12,14-tetrahydroxy-1-tremulene; D012717:Sesquiterpenes
keywords: Conocybe siliginea; cytotoxicity; sesquiterpenoids