title: Lewis base mediated halogenation/semipinacol rearrangement of diazo compounds: new access to α-halo-quaternary ketones.
abstract: A novel halogenation/semipinacol rearrangement of α-diazo alcohol catalyzed by Lewis base has been developed through a carbene-free mechanism. This semipinacol transposition, initiated by an electrophilic halogenation (X = Cl(+), Br(+), and I(+)) of diazo carbon event, furnished a convenient synthetic route for the efficient synthesis of α-halo-quaternary ketones under mild conditions.
authors.affiliation: School of Chemistry and Chemical Engineering, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing, 210093, P. R. China. cjzhu@nju.edu.cn.
authors.forename: Haibin
authors.initials: H
authors.lastname: Mao
authors.forename: Zhongkai
authors.initials: Z
authors.lastname: Tang
authors.forename: Hongwen
authors.initials: H
authors.lastname: Hu
authors.forename: Yixiang
authors.initials: Y
authors.lastname: Cheng
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Zheng
authors.forename: Chengjian
authors.initials: C
authors.lastname: Zhu