title: Histone H2B ubiquitination: signaling not scrapping.
abstract: Monoubiquitination of histone H2B has emerged as an important chromatin modification with roles not only in transcription but also in cell differentiation, DNA repair or mRNA processing. Recently, the genome-wide distribution of histone H2B ubiquitination in different organisms has been reported. In this review we discuss the mechanisms regulating H2B ubiquitination and its downstream effectors as well as the suggested functions for this mark in light of these recent studies.:
authors.affiliation: Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS UMR 7104, INSERM U 964, Université de Strasbourg, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Bonnet
authors.affiliation: Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS UMR 7104, INSERM U 964, Université de Strasbourg, France. Electronic address:devys@igbmc.fr.
authors.forename: Didier
authors.initials: D
authors.lastname: Devys
authors.affiliation: Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS UMR 7104, INSERM U 964, Université de Strasbourg, France. Electronic address:laszlo@igbmc.fr.
authors.forename: László
authors.initials: L
authors.lastname: Tora
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000235:genetics / Q000378:metabolism; D004260:DNA Repair / Q000235:genetics; D020869:Gene Expression Profiling; D055106:Genome-Wide Association Study; D006657:Histones / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction; D035602:Transcriptional Elongation Factors / Q000235:genetics; D025801:Ubiquitin / Q000235:genetics / Q000378:metabolism*; D057149:Ubiquitinated Proteins / Q000235:genetics / Q000378:metabolism*; D054875:Ubiquitination / Q000502:physiology*
chemical_list: D006657:Histones; D035602:Transcriptional Elongation Factors; D025801:Ubiquitin; D057149:Ubiquitinated Proteins