title: miR-92a regulates expression of synaptic GluA1-containing AMPA receptors during homeostatic scaling.
abstract: We investigated whether microRNAs could regulate AMPA receptor expression during activity blockade. miR-92a strongly repressed the translation of GluA1 receptors by binding the 3' untranslated region of rat GluA1 (also known as Gria1) mRNA and was downregulated in rat hippocampal neurons after treatment with tetrodotoxin and AP5. Deleting the seed region in GluA1 or overexpressing miR-92a blocked homeostatic scaling, indicating that miR-92a regulates the translation and synaptic incorporation of new GluA1-containing AMPA receptors.
authors.affiliation: 1] University of Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297, Bordeaux, France. [2] CNRS, Interdisciplinary Institute for Neuroscience, UMR 5297, Bordeaux, France. [3].
authors.forename: Mathieu
authors.initials: M
authors.lastname: Letellier
authors.affiliation: 1] University of Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297, Bordeaux, France. [2] CNRS, Interdisciplinary Institute for Neuroscience, UMR 5297, Bordeaux, France. [3].
authors.forename: Sara
authors.initials: S
authors.lastname: Elramah
authors.affiliation: 1] University of Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297, Bordeaux, France. [2] CNRS, Interdisciplinary Institute for Neuroscience, UMR 5297, Bordeaux, France. [3].
authors.forename: Magali
authors.initials: M
authors.lastname: Mondin
authors.affiliation: 1] University of Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297, Bordeaux, France. [2] CNRS, Interdisciplinary Institute for Neuroscience, UMR 5297, Bordeaux, France.
authors.forename: Anaïs
authors.initials: A
authors.lastname: Soula
authors.affiliation: 1] University of Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297, Bordeaux, France. [2] CNRS, Interdisciplinary Institute for Neuroscience, UMR 5297, Bordeaux, France.
authors.forename: Andrew
authors.initials: A
authors.lastname: Penn
authors.affiliation: 1] University of Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297, Bordeaux, France. [2] CNRS, Interdisciplinary Institute for Neuroscience, UMR 5297, Bordeaux, France.
authors.forename: Daniel
authors.initials: D
authors.lastname: Choquet
authors.affiliation: 1] University of Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297, Bordeaux, France. [2] CNRS, Interdisciplinary Institute for Neuroscience, UMR 5297, Bordeaux, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Landry
authors.affiliation: 1] University of Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297, Bordeaux, France. [2] CNRS, Interdisciplinary Institute for Neuroscience, UMR 5297, Bordeaux, France. [3].
authors.forename: Olivier
authors.initials: O
authors.lastname: Thoumine
authors.affiliation: 1] University of Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297, Bordeaux, France. [2] CNRS, Interdisciplinary Institute for Neuroscience, UMR 5297, Bordeaux, France. [3].
authors.forename: Alexandre
authors.initials: A
authors.lastname: Favereaux
mesh_terms: D000818:Animals; D001483:Base Sequence; D015536:Down-Regulation / Q000235:genetics*; D057809:HEK293 Cells; D006624:Hippocampus / Q000378:metabolism / Q000502:physiology; D006706:Homeostasis / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000037:antagonists & inhibitors / Q000235:genetics*; D008969:Molecular Sequence Data; D009474:Neurons / Q000378:metabolism / Q000502:physiology; D011485:Protein Binding / Q000235:genetics; D012333:RNA, Messenger / Q000037:antagonists & inhibitors / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors* / Q000235:genetics* / Q000378:metabolism; D013569:Synapses / Q000235:genetics*; D020506:Untranslated Regions / Q000235:genetics
chemical_list: D035683:MicroRNAs; D012333:RNA, Messenger; D018091:Receptors, AMPA; D020506:Untranslated Regions; C000592377:MIRN92 microRNA, rat