title: Sphincter electromyography in diabetes mellitus and multiple system atrophy.
abstract: OBJECTIVE
  Abnormalities of external anal sphincter electromyography (EAS-EMG) characterize multiple system atrophy (MSA) and focal cauda equina or conus medullaris lesions. This study is designed to determine whether and how diabetic polyneuropathy (DPN) affects EAS as compared to the abnormalities seen in MSA.
  
  
  METHODS
  We conducted multi-motor unit potential (MUP) analysis of EAS in 22 healthy controls, 32 diabetes mellitus (DM) patients without neuropathy, 38 DPN patients, and 68 MSA patients.
  
  
  RESULTS
  DPN patients had a significant (P < 0.01) increase in MUP mean duration, mean amplitude, percentage of long duration MUPs, and satellite rate, but to a lesser extent than MSA. Mean duration and satellite rate showed the least overlap among different groups in individual value distributions.
  
  
  CONCLUSIONS
  Compared with MSA, DPN affects EAS to a lesser degree as judged by neurogenic MUP abnormalities in EMG. Mean duration and satellite rate may serve as the most discriminating aspects in MUP analysis of EAS.
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Jian
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Pan
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing, China.
authors.forename: Zaiqiang
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing, China.
authors.forename: Jinxi
authors.initials: J
authors.lastname: Lin
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing, China.
authors.forename: Na
authors.initials: N
authors.lastname: Chen
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Wu
authors.affiliation: Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China.
authors.forename: Han
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing, China.
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China.
authors.forename: Liying
authors.initials: L
authors.lastname: Cui
authors.affiliation: Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China.
authors.forename: Xiaofu
authors.identifier: http://orcid.org/0000-0002-2960-9931
authors.initials: X
authors.lastname: Tang
mesh_terms: D000328:Adult; D000368:Aged; D001003:Anal Canal / Q000294:innervation* / Q000473:pathology; D001284:Atrophy; D016022:Case-Control Studies; D003929:Diabetic Neuropathies / Q000175:diagnosis* / Q000503:physiopathology; D004576:Electromyography; D019054:Evoked Potentials, Motor; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000175:diagnosis* / Q000503:physiopathology; D011237:Predictive Value of Tests; D060525:Pudendal Nerve / Q000503:physiopathology*; D013997:Time Factors
keywords: diabetes mellitus; diabetic polyneuropathy; external anal sphincter; multiple system atrophy; sphincter electromyography