title: Prostate cancer cells alter the nature of their calcium influx to promote growth and acquire apoptotic resistance.
abstract: In this issue of Cancer Cell, Dubois and colleagues report a remodeling of calcium influx in prostate cancer cells. Prostate cancer cells can undergo an oncogenic switch from a calcium influx pathway capable of inducing apoptosis involving ORAI1 channels to a pro-proliferative calcium influx pathway involving ORAI1/3 heteromeric channels.
authors.affiliation: The School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Brisbane, Woolloongabba QLD 4102, Australia. Electronic address: gregm@uq.edu.au.
authors.forename: Gregory R
authors.initials: GR
authors.lastname: Monteith
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism*; D000818:Animals; D015220:Calcium Channels / Q000378:metabolism*; D020013:Calcium Signaling; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D006801:Humans; D008297:Male; D000071740:ORAI1 Protein; D011471:Prostatic Neoplasms / Q000378:metabolism*
chemical_list: D015220:Calcium Channels; D000071740:ORAI1 Protein; C510746:ORAI1 protein, human; C522867:Orai3 protein, human