title: Damage induced by paracetamol compared with N-acetylcysteine.
abstract: BACKGROUND
  This study investigated the effect of thiamine pyrophosphate (TPP) on oxidative liver damage induced in rats with high-dose paracetamol.
  
  
  METHODS
  Rats for this experiment were divided into the following groups: healthy control, paracetamol control, thiamine + paracetamol, TPP + paracetamol, and N-acetylcysteine + paracetamol. Oxidant and antioxidant parameters and liver function test levels were compared between the groups.
  
  
  RESULTS
  The results show that TPP and N-acetylcysteine with paracetamol equally prevented a rise in oxidants such as malondialdehyde and nitric oxide. They also prevented a decrease in enzymatic and nonenzymatic antioxidants such as glutathione, glutathione peroxidase, glutaredoxin, glutathione S-transferase, superoxide dismutase, and catalase in the rat liver.
  
  
  CONCLUSIONS
  Thiamine pyrophosphate and N-acetylcysteine had a similar positive effect on oxidative damage caused by paracetamol hepatotoxicity. These findings show that TPP may be beneficial in paracetamol hepatotoxicity.
authors.affiliation: Department of General Surgery, Ataturk University, Erzurum, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Kisaoglu
authors.affiliation: Department of General Surgery, Ataturk University, Erzurum, Turkey.
authors.forename: Bunyami
authors.initials: B
authors.lastname: Ozogul
authors.affiliation: Department of Pediatric Neurology, Diyarbakir Research and Educational Hospital, Diyarbakir, Turkey. Electronic address: turan78tr@hotmail.com.
authors.forename: Mehmet Ibrahim
authors.initials: MI
authors.lastname: Turan
authors.affiliation: Department of General Surgery, Erzincan University, Erzincan, Turkey.
authors.forename: Ismayil
authors.initials: I
authors.lastname: Yilmaz
authors.affiliation: Department of General Surgery, Ibni Sina Hospital, Kayseri, Turkey.
authors.forename: Ismail
authors.initials: I
authors.lastname: Demiryilmaz
authors.affiliation: Department of General Surgery, Ataturk University, Erzurum, Turkey.
authors.forename: Sabri Selcuk
authors.initials: SS
authors.lastname: Atamanalp
authors.affiliation: Department of Biochemistry, Ataturk University, Erzurum, Turkey.
authors.forename: Ebubekir
authors.initials: E
authors.lastname: Bakan
authors.affiliation: Department of Pharmacology, Recep Tayyip Erdogan University, Rize, Turkey.
authors.forename: Halis
authors.initials: H
authors.lastname: Suleyman
mesh_terms: D000082:Acetaminophen / Q000633:toxicity*; D000111:Acetylcysteine / Q000494:pharmacology*; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D005978:Glutathione / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008099:Liver / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013835:Thiamine Pyrophosphate / Q000494:pharmacology*
chemical_list: D000082:Acetaminophen; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005978:Glutathione; D013835:Thiamine Pyrophosphate; D000111:Acetylcysteine
keywords: hepatotoxicity; paracetamol; rat; thiamine; thiamine pyrophosphate