title: Arginase I levels are decreased in the plasma of pediatric patients with atopic dermatitis.
abstract: BACKGROUND
  Serum arginase levels have been shown to be elevated in conditions, such as trauma, cancer, chronic wounds, pregnancy, and diabetes. This also has been found to be true in atopic diseases, such as asthma and allergic rhinitis.
  
  
  OBJECTIVE
  To study arginase activity in patients with atopic dermatitis (AD).
  
  
  METHODS
  In this pilot study, arginase activity levels in 15 pediatric patients with AD were compared with those in controls to determine whether arginase levels in AD are altered as in patients with other atopic diseases.
  
  
  RESULTS
  In contrast to the other diseases studied, arginase activity was found to be decreased in granulocytes and in the plasma of patients with AD compared with controls. This finding was coupled with a trend toward higher L-arginine plasma levels.
  
  
  CONCLUSIONS
  In AD, a different mechanism of arginine metabolism seems to be stimulated, leading to the formation of nitric oxide pathway components causing suppression of the arginase pathway and impairment in skin hydration, collagen synthesis, and wound healing.
authors.affiliation: Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, Louisiana; Division of Allergy and Immunology, Children's Hospital of New Orleans, New Orleans, Louisiana. Electronic address: varsen@lsuhsc.edu.
authors.forename: Victoria
authors.initials: V
authors.lastname: Dimitriades
authors.affiliation: Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana; Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana.
authors.forename: Paulo C
authors.initials: PC
authors.lastname: Rodriguez
authors.affiliation: Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, Louisiana.
authors.forename: Jovanny
authors.initials: J
authors.lastname: Zabaleta
authors.affiliation: Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, Louisiana; Division of Allergy and Immunology, Children's Hospital of New Orleans, New Orleans, Louisiana; Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana.
authors.forename: Augusto C
authors.initials: AC
authors.lastname: Ochoa
mesh_terms: D000293:Adolescent; D001119:Arginase / Q000097:blood*; D001120:Arginine / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000097:blood* / Q000201:enzymology* / Q000276:immunology; D004789:Enzyme Activation; D004804:Eosinophils; D005260:Female; D006098:Granulocytes / Q000201:enzymology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D007223:Infant; D007958:Leukocyte Count; D008297:Male; D012720:Severity of Illness Index
chemical_list: D007073:Immunoglobulin E; D001120:Arginine; C574619:ARG1 protein, human; D001119:Arginase