title: Lower free testosterone level is correlated with left ventricular diastolic dysfunction in asymptomatic middle-aged men with type 2 diabetes mellitus.
abstract: OBJECTIVE
  Low testosterone (T) level is associated with cardiovascular risk factors. However, the relationship between T level and heart function in asymptomatic men with type 2 diabetes mellitus (T2DM) is unknown.
  
  
  METHODS
  A total of 325 men were recruited who had no history, symptoms, or signs of heart disease.
  
  
  RESULTS
  T2DM had significantly lower free T (FT) levels than those with normal glucose metabolism (NGM) (428 ± 38 pmol/l vs. 444 ± 38 pmol/l, p = 0.0002), and had an increased risk of LVDD (66.1% vs. 31.8%). There was a significant difference in FT level between subjects with and without LVDD among those with T2DM (421 ± 37 pmol/l vs. 442 ± 40 pmol/l, p = 0.0007), but not among those with NGM (439 ± 37 pmol/l vs. 447 ± 39 pmol/l, p = 0.247) or in the group overall (426 ± 38 pmol/l vs. 445 ± 38 pmol/l, p = 0.156). Lower FT level was significantly associated with LVDD [univariate odds ratio (OR) = 0.63, p = 0.032; multivariate OR = 0.71, p = 0.039]. Receiver operating characteristic curve analysis of the usefulness of FT level for predicting LVDD showed an area under the curve (AUC) of 0.85 for T2DM (p < 0.001) and 0.66 for NGM (p < 0.05). FT level had a high predictive value for LVDD in T2DM (83% for FT < 414 pmol/l), but a low predictive value in NGM (61% for FT < 423 pmol/l). Comparison of the AUCs showed that FT level was more strongly correlated with LVDD in T2DM than in NGM.
  
  
  CONCLUSIONS
  Lower FT level is correlated with LVDD in asymptomatic middle-aged men with T2DM.
authors.affiliation: Department of Geriatrics, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Jin
authors.forename: Y
authors.initials: Y
authors.lastname: Lou
authors.forename: H
authors.initials: H
authors.lastname: Chen
authors.forename: T
authors.initials: T
authors.lastname: Li
authors.forename: X
authors.initials: X
authors.lastname: Bao
authors.forename: Q
authors.initials: Q
authors.lastname: Liu
authors.forename: X
authors.initials: X
authors.lastname: He
mesh_terms: D015415:Biomarkers / Q000097:blood*; D009202:Cardiomyopathies / Q000209:etiology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013739:Testosterone / Q000009:adverse effects / Q000172:deficiency*; D018487:Ventricular Dysfunction, Left / Q000209:etiology*
chemical_list: D015415:Biomarkers; D013739:Testosterone