title: Late-onset subcutaneous scalp calcifications in a patient with pseudo-pseudohypoparathyroidism.
abstract: Ectopic calcifications and even bone formation have been linked to GNAS gene mutations. A 51-year-old Caucasian female had been diagnosed of pseudo-pseudohypoparathyroidism (PPHP) in 1989. She has always had normal serum parathyroid hormone, calcium, and phosphorus levels. A non-contrast computed tomography of the head was done in 2013 and it showed finely speckled subcutaneous calcifications in the high convexity of the head. Cutaneous exploration did not show any abnormality. We herein report an unusual case of late-onset scalp calcifications in a patient with PPHP.
authors.affiliation: Department of Endocrinology, University Hospital "Marques de Valdecilla", University of Cantabria, 39008, Santander, Cantabria, Spain, lramos@humv.es.
authors.forename: Laura
authors.initials: L
authors.lastname: Ramos
authors.forename: María
authors.initials: M
authors.lastname: Piedra
authors.forename: Elena
authors.initials: E
authors.lastname: Sánchez
authors.forename: José A
authors.initials: JA
authors.lastname: Amado
mesh_terms: D017668:Age of Onset; D002114:Calcinosis / Q000209:etiology* / Q000473:pathology; D002864:Chromogranins; D005260:Female; D016368:Frameshift Mutation; D019205:GTP-Binding Protein alpha Subunits, Gs / Q000235:genetics; D006801:Humans; D008875:Middle Aged; D011556:Pseudopseudohypoparathyroidism / Q000150:complications* / Q000235:genetics / Q000473:pathology; D012535:Scalp / Q000473:pathology*
chemical_list: D002864:Chromogranins; C406732:GNAS protein, human; D019205:GTP-Binding Protein alpha Subunits, Gs