title: Administration of Gemcitabine for Metastatic Adenocarcinoma during Pregnancy: A Case Report and Review of the Literature.
abstract: We present the case of a 38-year-old woman diagnosed with metastatic adenocarcinoma of the biliary tract in the 18th week of pregnancy. Chemotherapy based on cisplatin and gemcitabine was administered, reaching disease stabilization until late-preterm delivery at 35 + 0 weeks of gestation. The infant was healthy and showed no malformations. Her head circumference was small, yet no neurological and behavioral defects have been detected. Development was normal during 14 months of follow-up. We discuss the implications of metastatic cancer in pregnancy with focus on therapeutic options for metastatic adenocarcinoma of the biliary tract. In this context, available data for the active regimens in biliary tract cancers-platinum compounds and gemcitabine-are discussed. This report is the fourth in the literature detailing the application of gemcitabine during pregnancy and the first presenting longer term follow-up, complementing available evidence that gemcitabine-based regimens are feasible in this situation.
authors.affiliation: Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Wiesweg
authors.affiliation: Dipartimento di Ematologia ed Oncologia, Azienda ospedaliera Città della Salute e della Scienza di Torino, Torino, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Aydin
authors.affiliation: Department of Gynecology and Obstetrics, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Koeninger
authors.affiliation: Department of Neonatology, Clinic for Pediatrics I, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Stein
authors.affiliation: Department of Neuropediatrics, Developmental Neurology and Social Pediatrics, Clinic for Pediatrics I, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Schara
authors.affiliation: Hematology/Oncology Group Practice, Koblenz, Germany.
authors.forename: C
authors.initials: C
authors.lastname: van Roye
authors.affiliation: Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Hense
authors.affiliation: Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Welt
authors.affiliation: Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Schuler
keywords: adenocarcinoma; chemotherapy; cholangiocarcinoma; gemcitabine; pregnancy