title: 1H NMR studies of binary and ternary dapsone supramolecular complexes with different drug carriers: EPC liposome, SBE-β-CD and β-CD.
abstract: Binary and ternary systems composed of dapsone, sulfobutylether-β-cyclodextrin (SBE-β-CD), β-CD and egg phosphatidylcholine (EPC) were evaluated using 1D ROESY, saturation transfer difference NMR and diffusion experiments (DOSY) revealing the binary complexes Dap/β-CD (K(a) 1396 l mol(-1)), Dap/SBE-β-CD (K(a) 246 l mol(-1)), Dap/EPC (K(a) 84 l mol(-1)) and the ternary complex Dap/β-CD/EPC (K(a) 18 l mol(-1)) in which dapsone is more soluble.
authors.affiliation: University of Campinas, Chemistry Institute, Campinas, Brazil.
authors.forename: Lucas
authors.initials: L
authors.lastname: Martins
authors.forename: Monica
authors.initials: M
authors.lastname: Arrais
authors.forename: Alexandre
authors.initials: A
authors.lastname: de Souza
authors.forename: Anita
authors.initials: A
authors.lastname: Marsaioli
mesh_terms: D003622:Dapsone / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D004530:Egg Yolk / Q000737:chemistry*; D046911:Macromolecular Substances / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010713:Phosphatidylcholines / Q000737:chemistry*; D011522:Protons; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D046911:Macromolecular Substances; D010713:Phosphatidylcholines; D011522:Protons; D047392:beta-Cyclodextrins; C093196:SBE4-beta-cyclodextrin; D003622:Dapsone; C031215:betadex
keywords: EPC liposome; NMR; SBE-β-CD; dapsone; β-CD