title: Dermatologic and dental aspects of the 2012 International Tuberous Sclerosis Complex Consensus Statements.
abstract: OBJECTIVE
  The 2012 International Tuberous Sclerosis Complex Clinical Consensus Conference was convened to update the last consensus statement in 1998. Skin and dental lesions are common in tuberous sclerosis complex (TSC) and are a frequent concern for patients. Recognition of these lesions is imperative for early diagnosis, given the treatment advances that may improve patient outcomes.
  
  
  OBJECTIVE
  To detail recommendations for the diagnosis, surveillance, and management of skin and dental lesions in TSC.
  
  
  METHODS
  The TSC Dermatology and Dentistry Subcommittee, 1 of 12 subcommittees, reviewed the relevant literature from 1997 to 2012.
  
  
  RESULTS
  A consensus on skin and dental issues was achieved within the Dermatology and Dentistry Subcommittee before recommendations were presented, discussed, and agreed on in a group meeting of all subcommittees from June 14 to 15, 2012.
  
  
  CONCLUSIONS
  Skin and dental findings comprise 4 of 11 major features and 3 of 6 minor features in the diagnostic criteria. A definite diagnosis of TSC is defined as the presence of at least 2 major features or 1 major and 2 or more minor features; in addition, a pathological mutation in TSC1 or TSC2 is diagnostic. Skin and oral examinations should be performed annually and every 3 to 6 months, respectively. Intervention may be indicated for TSC skin or oral lesions that are bleeding, symptomatic, disfiguring, or negatively affecting function. Options presented include surgical excision, laser(s), or use of a mammalian target of rapamycin inhibitor.
authors.affiliation: Department of Dermatology, Stanford University School of Medicine, Stanford, California.
authors.forename: Joyce M C
authors.initials: JM
authors.lastname: Teng
authors.affiliation: Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
authors.forename: Edward W
authors.initials: EW
authors.lastname: Cowen
authors.affiliation: Department of Dermatology, Graduate School of Medicine, Osaka University, Osaka, Japan.
authors.forename: Mari
authors.initials: M
authors.lastname: Wataya-Kaneda
authors.affiliation: Division of Pediatric Dentistry and Orthodontics, Cincinnati Children's Hospital, Cincinnati, Ohio.
authors.forename: Elizabeth S
authors.initials: ES
authors.lastname: Gosnell
authors.affiliation: Division of Dermatology, Department of Pediatrics, Nationwide Children's Hospital and Ohio State University, Columbus.
authors.forename: Patricia M
authors.initials: PM
authors.lastname: Witman
authors.affiliation: Departments of Dermatology and Pediatrics, University of Texas-Houston Medical School, Houston.
authors.forename: Adelaide A
authors.initials: AA
authors.lastname: Hebert
authors.affiliation: Santa Rosa Family and Cosmetic Dentistry, Santa Rosa, California.
authors.forename: Greg
authors.initials: G
authors.lastname: Mlynarczyk
authors.affiliation: Section of Dermatology, Department of Medicine, University of Chicago, Chicago, Illinois.
authors.forename: Keyoumars
authors.initials: K
authors.lastname: Soltani
authors.affiliation: Department of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, Maryland.
authors.forename: Thomas N
authors.initials: TN
authors.lastname: Darling
mesh_terms: D000367:Age Factors; D003245:Consensus Statements as Topic; D003743:Dental Enamel / Q000473:pathology; D005350:Fibroma / Q000209:etiology* / Q000628:therapy; D006801:Humans; D009062:Mouth Neoplasms / Q000209:etiology* / Q000628:therapy; D017410:Practice Guidelines as Topic; D012680:Sensitivity and Specificity; D012871:Skin Diseases / Q000209:etiology* / Q000628:therapy; D014402:Tuberous Sclerosis / Q000150:complications / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy; D000077004:Tuberous Sclerosis Complex 1 Protein; D000077005:Tuberous Sclerosis Complex 2 Protein; D025521:Tumor Suppressor Proteins / Q000235:genetics
chemical_list: C000624650:TSC1 protein, human; C000624653:TSC2 protein, human; D000077004:Tuberous Sclerosis Complex 1 Protein; D000077005:Tuberous Sclerosis Complex 2 Protein; D025521:Tumor Suppressor Proteins