title: Endothelial cells in dengue hemorrhagic fever.
abstract: Therapies to prevent or reverse endothelial dysfunction and vascular leak found in dengue hemorrhagic fever (DHF) have not been identified. In this review we summarize dengue viruses and the spectrum of human disease and highlight evidence of endothelial cell dysfunction in DHF based on studies in patients and mouse and tissue culture models. Evidence suggests that both virus antigen and host immune response, can cause endothelial cell dysfunction and weaken endothelial barrier integrity. We suggest possible therapeutic interventions and highlight how therapies targeting altered endothelial function might be evaluated in animal models and in patients with DHF.
authors.affiliation: Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA. Electronic address: anon.srikiatkhachorn@umassmed.edu.
authors.forename: Anon
authors.initials: A
authors.lastname: Srikiatkhachorn
authors.affiliation: Faculty of Tropical Medicine, Department of Microbiology and Immunology, Mahidol University, Bangkok, Thailand; Department of Tropical Medicine, Medical Microbiology and Pharmacology, University of Hawaii, USA.
authors.forename: James F
authors.initials: JF
authors.lastname: Kelley
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D003716:Dengue Virus / Q000187:drug effects / Q000502:physiology*; D042783:Endothelial Cells / Q000276:immunology / Q000821:virology*; D004730:Endothelium, Vascular / Q000276:immunology / Q000821:virology; D006801:Humans; D019595:Severe Dengue / Q000276:immunology / Q000628:therapy / Q000821:virology*
chemical_list: D000998:Antiviral Agents
keywords: Dengue hemorrhagic fever; Dengue virus; Endothelial barrier integrity; Endothelial cells; Vascular leak