title: Drug-induced pseudo-Sezary syndrome: a case report and literature review.
abstract: Pseudo-Sezary syndrome is a benign lymphoproliferative disorder, which clinically and pathologically mimics true Sezary syndrome. In this article, a case of pseudo-Sezary syndrome and review the literature has been reported. The patient was a 51-year-old man who developed erythroderma and palmoplantar keratoderma. The patient's medication history included fosinopril and combination metoprolol/hydrochlorothiazide. Flow cytometry showed a population of 2500 "Sezary-like" CD4726 T cells per microliter in the peripheral blood. Skin biopsy showed numerous atypical lymphocytes with epidermotropism, and there was matching dominant T-cell clonality in the skin and peripheral blood. After stopping all antihypertensive medications, the eruption resolved in its entirety.
authors.affiliation: Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, WI.
authors.forename: Margo J
authors.initials: MJ
authors.lastname: Reeder
authors.forename: Gary S
authors.initials: GS
authors.lastname: Wood
mesh_terms: D058671:Adrenergic beta-1 Receptor Antagonists / Q000009:adverse effects; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects; D000959:Antihypertensive Agents / Q000009:adverse effects*; D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D003937:Diagnosis, Differential; D004232:Diuretics / Q000009:adverse effects; D003875:Drug Eruptions / Q000209:etiology* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D005434:Flow Cytometry; D017328:Fosinopril / Q000009:adverse effects; D019672:Genes, T-Cell Receptor; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects; D007150:Immunohistochemistry; D008297:Male; D008790:Metoprolol / Q000009:adverse effects; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D012751:Sezary Syndrome / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D012867:Skin / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology / Q000473:pathology
chemical_list: D058671:Adrenergic beta-1 Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D015415:Biomarkers; D004232:Diuretics; D006852:Hydrochlorothiazide; D008790:Metoprolol; D017328:Fosinopril