title: Chemically assisted dissection by means of mesna in cholesteatoma surgery.
abstract: OBJECTIVE
  To investigate whether the use of mesna (sodium 2-mercaptoethanesulfonate), a mucolytic agent capable of breaking disulfur bonds, reduces the frequency of residual cholesteatoma in canal wall up tympanomastoidectomy.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Tertiary care otology and skull base centers.
  
  
  METHODS
  Two hundred fourteen patients operated on by means of canal wall up tympanomastoidectomy for a middle ear cholesteatoma.
  
  
  METHODS
  Planned staged canal wall up tympanomastoidectomy. In the study group, the cholesteatoma removal was performed with the support of chemically assisted dissection by using mesna. In the control group, the dissection of the disease was performed by means of a traditional mechanical technique alone.
  
  
  METHODS
  Prevalence of residual cholesteatoma at the second-stage operation in the 2 groups of study.
  
  
  RESULTS
  One hundred eight patients were treated with the ancillary use of mesna and one hundred six without chemically assisted dissection. A residual cholesteatoma was found in 12 (11.1%) of the 108 patients treated with chemically assisted dissection and in 26 (24.5%) of the 106 patients treated with mechanical dissection. After adjusting for potential confounders, CADISS procedure was associated with a significantly lower risk of having residual cholesteatoma (OR, 0.39; 95% CI, 0.18-0.84, p = 0.02).
  
  
  CONCLUSIONS
  This study showed that chemically assisted dissection by using mesna represents a valid support in reducing the frequency of residual disease in cholesteatoma surgery.
authors.affiliation: *Unit of Audiology and Pediatric Otorhinolaryngology, Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy; †Service d'Oto-Rhino-Laryngologie et Chirurgie Cervico-Faciale, Hôpital Nord-Chemin des Bourrelly, Marseille, France; and ‡Area of Otolaryngology, Rome American Hospital, Rome, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Vincenti
authors.forename: Jacques
authors.initials: J
authors.lastname: Magnan
authors.forename: Maria Silvia
authors.initials: MS
authors.lastname: Saccardi
authors.forename: Carlo
authors.initials: C
authors.lastname: Zini
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D018424:Cholesteatoma, Middle Ear / Q000601:surgery*; D004210:Dissection / Q000379:methods*; D005100:Expectorants / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008416:Mastoid / Q000601:surgery*; D015080:Mesna / Q000627:therapeutic use*; D008875:Middle Aged; D013506:Otologic Surgical Procedures / Q000379:methods; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D005100:Expectorants; D015080:Mesna