title: Effect of six-month lifestyle intervention on adiponectin, resistin and soluble tumor necrosis factor-α receptors in obese adolescents.
abstract: The aim of this study was to evaluate the effect of a six-month lifestyle intervention on adiponectin, resistin, and two soluble forms of tumor necrosis factor-α receptor (sTNFR) in obese adolescents. A total of 54 obese adolescents aged 10 to 16 years completed the program. Twenty-four adolescents with normal weight at baseline were used as a control group. Our results demonstrated that obese adolescents had abnormal lipid profile, homeostasis model assessment (HOMA) index, adiponectin level (5.6 ± 2.7 vs. 7.6 ± 2.9 μg/mL, p = 0.005) as well as resistin level (31.0 ± 9.0 vs. 24.3 ± 8.5 ng/mL, p = 0.003), whereas levels of both sTNFRs were similar to those in normal weight subjects. After the six-month lifestyle intervention, obese adolescents had a slight but significant drop in standard deviation score-body mass index (SDS-BMI), a significant decrease in waist circumference, total cholesterol, triglycerides, HOMA index, as well as resistin, and a significant increase in adiponectin and high-density lipoprotein-cholesterol. In adolescents without decreased SDS-BMI, no change was observed in adipokines. Changes in adiponectin correlated negatively with changes in waist circumference (r = -0.275, p = 0.044). Changes in resistin correlated positively with changes in triglycerides (r = 0.302, p = 0.027). The study demonstrated the increase of resistin and the decrease of adiponectin in obese adolescents. Lifestyle intervention improved adipokine abnormalities in obese subjects.
authors.affiliation: Laboratory of Pharmacology and Toxicology, Hospital Infántil de México Federico Gómez (HIMFG), Mexico City 06720, Mexico.
authors.forename: Fengyang
authors.initials: F
authors.lastname: Huang
authors.forename: Blanca Estela
authors.initials: BE
authors.lastname: Del-Río-Navarro
authors.forename: José Alfredo
authors.initials: JA
authors.lastname: Pérez-Ontiveros
authors.forename: Eliseo
authors.initials: E
authors.lastname: Ruiz-Bedolla
authors.forename: Omar Josué
authors.initials: OJ
authors.lastname: Saucedo-Ramírez
authors.forename: Santiago
authors.initials: S
authors.lastname: Villafaña
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Bravo
authors.forename: Patrick
authors.initials: P
authors.lastname: Mailloux-Salinas
authors.forename: Enrique
authors.initials: E
authors.lastname: Hong
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D015992:Body Mass Index; D002648:Child; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D006706:Homeostasis; D006801:Humans; D007333:Insulin Resistance; D008019:Life Style; D008297:Male; D008954:Models, Biological; D009765:Obesity / Q000097:blood / Q000628:therapy*; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood*; D052243:Resistin / Q000097:blood*; D014280:Triglycerides; D055105:Waist Circumference
chemical_list: D052242:Adiponectin; D008076:Cholesterol, HDL; D018124:Receptors, Tumor Necrosis Factor; D052243:Resistin; D014280:Triglycerides