title: Cationic oligo(p-phenylene vinylene) materials for combating drug resistance of cancer cells by light manipulation.
abstract: An unconventional strategy that can be temporally and remotely activated with light to combat the drug resistance of cancer cells is developed. A cell-membrane-anchored photosensitizer (OPV) is used to enhance anticancer drug uptake and restore toxicity in resistant cancer cells. This method recovers the activity of the already established anticancer drugs, and provides a new strategy for the development of light manipulation to combat anticancer resistance.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Bing
authors.initials: B
authors.lastname: Wang
authors.forename: Huanxiang
authors.initials: H
authors.lastname: Yuan
authors.forename: Zhang
authors.initials: Z
authors.lastname: Liu
authors.forename: Chenyao
authors.initials: C
authors.lastname: Nie
authors.forename: Libing
authors.initials: L
authors.lastname: Liu
authors.forename: Fengting
authors.initials: F
authors.lastname: Lv
authors.forename: Yilin
authors.initials: Y
authors.lastname: Wang
authors.forename: Shu
authors.initials: S
authors.lastname: Wang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D002412:Cations / Q000737:chemistry; D002463:Cell Membrane Permeability; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D019008:Drug Resistance, Neoplasm / Q000187:drug effects* / Q000528:radiation effects*; D006801:Humans; D008027:Light; D061986:MCF-7 Cells; D018613:Microscopy, Confocal; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000494:pharmacology*; D011145:Polyvinyls / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D002412:Cations; D017319:Photosensitizing Agents; D011145:Polyvinyls; C530822:oligo(p-phenylene vinylene); D004317:Doxorubicin
keywords: OPV; anticancer drugs; combat drug resistance; light manipulation; photosensitizer