title: Relationship of PCNA, C-erbB2 and CD44s expression with tumor grade and stage in urothelial carcinomas of the bladder.
abstract: In the present study, the intention was to reveal the relationship of histological grade and stage with c-erbB2, CD44s, and PCNA immunoreactivity in bladder urothelial carcinomas (UC). In our study, we evaluated 46 items of transurethral resection material of patients submitted by YYU Faculty of Medicine, Main Department of Pathology, with a mass revealed in their bladder after clinical and radiological studies at our laboratories and who were diagnosed with urothelial carcinomas. PCNA, c-erbB2, and CD44s were applied in an immunohistochemical manner comprised from nine low-malignant potential papillary urothelial neoplasia, 23 low-grade papillary urothelial carcinoma, and 14 high-grade papillary urothelial carcinoma. Immunostaining was scored according to the percentage of positive cells. The immunohistochemical study demonstrated that the c-erbB2 and PCNA staining ratio increased when an increase occurred in stage and grade. The CD44s staining ratio decreased. C-erbB2, PCNA, and CD44s appear to be a useful marker in the assessment of the prognosis and treatment options in urothelial carcinomas.
authors.affiliation: Department of Pathology, Diyarbakır Pediatry and Gynecology Hospital Diyarbakır, Turkey.
authors.forename: Ayhan
authors.initials: A
authors.lastname: Yıldırım
authors.affiliation: Department of Pathology, Sakarya University Sakarya, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kösem
authors.affiliation: Department of Pathology, Erzincan University Erzincan, Turkey.
authors.forename: Ilyas
authors.initials: I
authors.lastname: Sayar
authors.affiliation: Department of Pathology, Namık Kemal University Tekirdağ, Turkey.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Gelincik
authors.affiliation: Department of Radiology, Yüzüncü Yıl University Van, Turkey.
authors.forename: Alparslan
authors.initials: A
authors.lastname: Yavuz
authors.affiliation: Department of Urology, Erzincan University Erzincan, Turkey.
authors.forename: Aliseydi
authors.initials: A
authors.lastname: Bozkurt
authors.affiliation: Department of Biostatistic, Sakarya University Sakarya, Turkey.
authors.forename: Unal
authors.initials: U
authors.lastname: Erkorkmaz
authors.affiliation: Department of Pathology, Yüzüncü Yıl University Van, Turkey.
authors.forename: Irfan
authors.initials: I
authors.lastname: Bayram
keywords: C-erbB2; CD44; PCNA; Urothelial carcinomas; immunohistochemical study