title: Role of non-covalent and covalent interactions in cargo loading capacity and stability of polymeric micelles.
abstract: Polymeric micelles self-assembled from biodegradable amphiphilic block copolymers have been proven to be effective drug delivery carriers that reduce the toxicity and enhance the therapeutic efficacy of free drugs. Several reviews have been reported in the literature to discuss the importance of size/size distribution, stability and drug loading capacity of polymeric micelles for successful in vivo drug delivery. This review is focused on non-covalent and covalent interactions that are employed to enhance cargo loading capacity and in vivo stability, and to achieve nanosize with narrow size distribution. In particular, this review analyzes various non-covalent and covalent interactions and chemistry applied to introduce these interactions to the micellar drug delivery systems, as well as the effects of these interactions on micelle stability, drug loading capacity and release kinetics. Moreover, the factors that influence these interactions and the future research directions of polymeric micelles are discussed.
authors.affiliation: Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, Singapore 138669, Singapore; NUS Graduate School for Integrative Sciences & Engineering (NGS), National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore.
authors.forename: Xiyu
authors.initials: X
authors.lastname: Ke
authors.affiliation: Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, Singapore 138669, Singapore.
authors.forename: Victor Wee Lin
authors.initials: VW
authors.lastname: Ng
authors.affiliation: IBM Almaden Research Center, 650 Harry Road, San Jose, CA 95120, USA.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Ono
authors.affiliation: IBM Almaden Research Center, 650 Harry Road, San Jose, CA 95120, USA.
authors.forename: Julian M W
authors.initials: JM
authors.lastname: Chan
authors.affiliation: Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, Singapore 138669, Singapore; NUS Graduate School for Integrative Sciences & Engineering (NGS), National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore.
authors.forename: Sangeetha
authors.initials: S
authors.lastname: Krishnamurthy
authors.affiliation: Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: IBM Almaden Research Center, 650 Harry Road, San Jose, CA 95120, USA.
authors.forename: James L
authors.initials: JL
authors.lastname: Hedrick
authors.affiliation: Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, Singapore 138669, Singapore. Electronic address: yyyang@ibn.a-star.edu.sg.
authors.forename: Yi Yan
authors.initials: YY
authors.lastname: Yang
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding; D065546:Drug Liberation; D004355:Drug Stability; D006860:Hydrogen Bonding; D057927:Hydrophobic and Hydrophilic Interactions; D008823:Micelles; D015394:Molecular Structure; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D008823:Micelles; D011108:Polymers
keywords: Chemical conjugation; Chemical cross-linking; Hydrogen bonding interaction; Hydrophobic interaction; Ionic interaction; Polymeric micelles