title: Therapeutic perspectives of epigenetically active nutrients.
abstract: Many nutrients are known for a wide range of activities in prevention and alleviation of various diseases. Recently, their potential role in regulating human health through effects on epigenetics has become evident, although specific mechanisms are still unclear. Thus, nutriepigenetics/nutriepigenomics has emerged as a new and promising field in current epigenetics research in the past few years. In particular, polyphenols, as part of the central dynamic interaction between the genome and the environment with specificity at physiological concentrations, are well known to affect mechanisms underlying human health. This review summarizes the effects of dietary compounds on epigenetic mechanisms in the regulation of gene expression including expression of enzymes and other molecules responsible for drug absorption, distribution, metabolism and excretion in cancer, metabolic syndrome, neurodegenerative disorders and hormonal dysfunction.
authors.affiliation: Department of Nutritional Sciences, University Vienna, Vienna, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Remely
authors.affiliation: Clinical Institute of Medical Genetics, Department of Gynecology and Obstetrics, University Medical Centre Ljubljana, Ljubljana, Slovenia.
authors.forename: L
authors.initials: L
authors.lastname: Lovrecic
authors.affiliation: Department of Nutrition, Food Sciences and Physiology, University of Navarra, Pamplona, Spain.
authors.forename: A L
authors.initials: AL
authors.lastname: de la Garza
authors.affiliation: Department of Translational Research and New Technologies in Medicine and Surgery, Division of Medical Genetics, University of Pisa, Pisa, Italy.|Research Center Nutraceuticals and Food for Health - Nutrafood, University of Pisa, Pisa, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Migliore
authors.affiliation: Clinical Institute of Medical Genetics, Department of Gynecology and Obstetrics, University Medical Centre Ljubljana, Ljubljana, Slovenia.
authors.forename: B
authors.initials: B
authors.lastname: Peterlin
authors.affiliation: Department of Nutrition, Food Sciences and Physiology, University of Navarra, Pamplona, Spain.
authors.forename: F I
authors.initials: FI
authors.lastname: Milagro
authors.affiliation: Department of Nutrition, Food Sciences and Physiology, University of Navarra, Pamplona, Spain.|Physiopathology of Obesity and Nutrition, CIBERobn, Carlos III Health Research Institute, Madrid, Spain.
authors.forename: A J
authors.initials: AJ
authors.lastname: Martinez
authors.affiliation: Department of Nutritional Sciences, University Vienna, Vienna, Austria.
authors.forename: A G
authors.initials: AG
authors.lastname: Haslberger
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D003069:Coffee; D003474:Curcumin / Q000494:pharmacology; D004032:Diet; D044127:Epigenesis, Genetic / Q000187:drug effects*; D005492:Folic Acid / Q000494:pharmacology; D005502:Food; D005786:Gene Expression Regulation / Q000187:drug effects; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D006801:Humans; D024821:Metabolic Syndrome / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D019636:Neurodegenerative Diseases / Q000235:genetics*; D048789:Phytoestrogens / Q000494:pharmacology*; D059808:Polyphenols / Q000494:pharmacology; D012436:S-Adenosylmethionine / Q000494:pharmacology; D012643:Selenium / Q000494:pharmacology; D014131:Trace Elements / Q000494:pharmacology*; D014805:Vitamin B 12 / Q000494:pharmacology; D014803:Vitamin B Complex / Q000494:pharmacology; D014815:Vitamins / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D003069:Coffee; D048789:Phytoestrogens; D059808:Polyphenols; D014131:Trace Elements; D014815:Vitamins; D014803:Vitamin B Complex; D012436:S-Adenosylmethionine; D005492:Folic Acid; D012643:Selenium; D003474:Curcumin; D014805:Vitamin B 12