title: Atypical femoral fracture combined with osteonecrosis of jaw during osteoporosis treatment with bisphosphonate.
abstract: Bisphosphonate, a potent anti-resorptive agent, is generally accepted as a safe, effective, well tolerated treatment for postmenopausal osteoporosis. Atypical femoral fracture (AFF) and bisphosphonate related osteonecrosis of jaw (BRONJ) are the increasing morbidities in patients treated with long term bisphosphonate. Pathogenic mechanisms of AFF and BRONJ are not fully identified and not identical. We report a case of BRONJ followed by AFF and its nonunion in a 67-year-old woman patient receiving an oral bisphosphonate during 7 years for the treatment of osteoporosis.
authors.affiliation: Department of Orthopaedic Surgery, Konyang University College of Medicine, Daejeon, Korea.
authors.forename: Yougun
authors.initials: Y
authors.lastname: Won
authors.affiliation: Department of Orthopaedic Surgery, Yonsei Univeristy College of Medicine, Seoul, Korea.
authors.forename: Joon-Ryul
authors.initials: JR
authors.lastname: Lim
authors.affiliation: Department of Orthopaedic Surgery, Yonsei Univeristy College of Medicine, Seoul, Korea.
authors.forename: Young-Hwan
authors.initials: YH
authors.lastname: Kim
authors.affiliation: Department of Orthopaedic Surgery, Aju University College of Medicine, Suwon, Korea.
authors.forename: Hyung-Keun
authors.initials: HK
authors.lastname: Song
authors.affiliation: Department of Orthopaedic Surgery, Yonsei Univeristy College of Medicine, Seoul, Korea.
authors.forename: Kyu Hyun
authors.initials: KH
authors.lastname: Yang
keywords: Atypical femoral fracture; Bisphosphonate