title: A retrospective analysis of the effect of salpingectomy on serum antiMüllerian hormone level and ovarian reserve.
abstract: OBJECTIVE
  To determine whether previous salpingectomy is associated with serum antiMüllerian hormone (AMH) level and ovarian reserve in women under 40 years presenting for in vitro fertilization and embryo transfer.
  
  
  METHODS
  We retrospectively compared serum AMH levels measured on the ovulation induction initiation day in patients with unilateral salpingectomy, bilateral salpingectomy, and no tubal surgery, and examined the relationship with length of time after surgery and in vitro fertilization and embryo transfer parameters.
  
  
  RESULTS
  A total of 198 women were included; 83 received unilateral salpingectomy, 41 bilateral salpingectomy, and 74 no tubal surgery. The baseline characteristics of the groups were similar. The mean AMH level was significantly higher in women without tubal surgery as compared with those with bilateral salpingectomy (183.48 vs 127.11 fmol/mL; P ≤ .037). The mean follicle stimulation hormone level was significantly lower in women without surgery as compared with those with bilateral salpingectomy (7.85 vs 9.13 mIU/mL; P = .048). No significant differences in duration of gonadotropin therapy, amount of gonadotropin used, estradiol level on the human chorionic gonadotropin injection day, thickness of the endometrium, number of oocytes retrieved, number of 2-pronuclei, viable embryos, and good quality embryos were found between the 3 groups. AMH level was not correlated with the number of oocytes or age in women that had undergone unilateral or bilateral salpingectomy.
  
  
  CONCLUSIONS
  Salpingectomy is associated with decreased AMH level and increased follicle stimulation hormone in women seeking in vitro fertilization, though AMH level is not correlated with the number of oocytes retrieved in patients that have undergone unilateral or bilateral salpingectomy. These results suggest that salpingectomy is associated with decreased ovarian reserve.
authors.affiliation: Obstetrics and Gynecology Hospital of Fudan University Shanghai, Shanghai, China.
authors.forename: Xu-ping
authors.initials: XP
authors.lastname: Ye
authors.affiliation: Genetic and IVF Center of Shanghai Jiai, Shanghai, China. Electronic address: yyzu@163.com.
authors.forename: Yue-zhou
authors.initials: YZ
authors.lastname: Yang
authors.affiliation: Obstetrics and Gynecology Hospital of Fudan University Shanghai, Shanghai, China; Genetic and IVF Center of Shanghai Jiai, Shanghai, China.
authors.forename: Xiao-xi
authors.initials: XX
authors.lastname: Sun
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D065851:Ovarian Reserve; D012189:Retrospective Studies; D058994:Salpingectomy
chemical_list: D054304:Anti-Mullerian Hormone
keywords: AMH; IVF-ET; antiMüllerian hormone; ovarian reserve; salpingectomy