title: Access to novel functionalized trifluoromethyl β-lactams by ring expansion of aziridines.
abstract: From carboxylic acid trifluoromethyl aziridines, halogeno β-lactams were obtained stereoselectively by ring expansion. Different conditions such as radical, organometallic reactions allowed easy and selective access to CF3-β-lactams substituted at the C-3 position.
authors.affiliation: Laboratoire BioCIS-CNRS, Faculté de Pharmacie, LabEx LERMIT, Univ. Paris-Sud, rue J. B. Clément, F-92296 Châtenay-Malabry, France. benoit.crousse@u-psud.fr.
authors.forename: S
authors.initials: S
authors.lastname: Decamps
authors.forename: L
authors.initials: L
authors.lastname: Sevaille
authors.forename: S
authors.initials: S
authors.lastname: Ongeri
authors.forename: B
authors.initials: B
authors.lastname: Crousse
mesh_terms: D001388:Aziridines / Q000737:chemistry*; D007769:Lactams / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D001388:Aziridines; D007769:Lactams