title: Primary Ewing's sarcoma of the cranium: case series and review of literature.
abstract: Primary Ewing's sarcoma (EWS) of the cranium is extremely rare. It accounts for <1% of cases. We retrospectively analyzed our EWS cases to determine those which had a primary cranial involvement. Out of a total of 332 cases of EWS registered between the years 2000 and 2011, 7 were of the primary cranial involvement. Treatment modalities included surgery, chemotherapy, and radiotherapy (RT), as indicated. The follow-up ranged from 8 months to 7.5 years. In our study, parieto-occipital region was the commonest site. Most patients presented with localized disease and swelling of the scalp. Excision followed by chemotherapy or RT appears to have good survival rates. At a median follow-up of 32.2 months, only one patient had a recurrence, and was successfully salvaged with second line chemotherapy. These cases illustrate that a multi-disciplinary approach in patients with EWS of the cranium results in a good outcome.
authors.affiliation: Department of Medical Oncology, Nizam's Institute of Medical Sciences, Hyderabad, India.
authors.forename: Kalpathi
authors.initials: K
authors.lastname: Krishnamani
authors.forename: Thota Narender
authors.initials: TN
authors.lastname: Kumar
authors.forename: Linga Vijay
authors.initials: LV
authors.lastname: Gandhi
authors.forename: Digumarti
authors.initials: D
authors.lastname: Raghunadharao
authors.forename: Gundeti
authors.initials: G
authors.lastname: Sadashivudu
authors.forename: Uppin
authors.initials: U
authors.lastname: Megha
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011859:Radiography; D012512:Sarcoma, Ewing / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy; D012888:Skull Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy