title: Synthesis of rhodamine-labelled dieckol: its unique intracellular localization and potent anti-inflammatory activity.
abstract: Rhodamine-labelled dieckol (1) synthesized through a click reaction was found to be localized in the endoplasmic reticulum (ER) of RAW 264.7 cells. Anti-inflammatory activity of compound was considerably greater than that of dieckol itself.
authors.affiliation: School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Korea.
authors.forename: Jong Hwan
authors.initials: JH
authors.lastname: Kwak
authors.forename: Yanxia
authors.initials: Y
authors.lastname: He
authors.forename: Byungkwon
authors.initials: B
authors.lastname: Yoon
authors.forename: Seyoung
authors.initials: S
authors.lastname: Koo
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Yang
authors.forename: Eun Ju
authors.initials: EJ
authors.lastname: Kang
authors.forename: Bong Ho
authors.initials: BH
authors.lastname: Lee
authors.forename: Seung-Yun
authors.initials: SY
authors.lastname: Han
authors.forename: Yung Choon
authors.initials: YC
authors.lastname: Yoo
authors.forename: Kyung Bok
authors.initials: KB
authors.lastname: Lee
authors.forename: Jong Seung
authors.initials: JS
authors.lastname: Kim
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D001572:Benzofurans / Q000737:chemistry*; D002460:Cell Line; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D008070:Lipopolysaccharides / Q000633:toxicity; D008264:Macrophages / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D018613:Microscopy, Confocal; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D012235:Rhodamines / Q000737:chemistry*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D001572:Benzofurans; D015850:Interleukin-6; D008070:Lipopolysaccharides; D016328:NF-kappa B; D012235:Rhodamines; D014409:Tumor Necrosis Factor-alpha; C503840:dieckol; D009569:Nitric Oxide; D020928:Mitogen-Activated Protein Kinases