title: Lunasin as a promising health-beneficial peptide.
abstract: Lunasin, a 43 amino acid polypeptide originally isolated from soybean, is known to produce multiple health benefits, including anti-hypertension, antioxidant activity, cancer prevention or therapy, anti-inflammation, hypocholesterolemic activity, anti-obesity and immunomodulation. These effects are believed to be due to its unique structure that includes a putative helical region, an Arg-Gly-Asp (RGD) motif and an Asp-rich carboxyl terminus. The focus of this article is to summarize the discovery, characterization and biological activities of lunasin, which will provide a reference for the future development and utilization of lunasin, and a basis for exploring the underlying mechanisms of these health-beneficial functions.
authors.affiliation: College of Health Science, Wuhan Sports University, Wuhan, China. chenning@wipe.edu.cn.
authors.forename: J
authors.initials: J
authors.lastname: Liu
authors.forename: S-H
authors.initials: SH
authors.lastname: Jia
authors.forename: M
authors.initials: M
authors.lastname: Kirberger
authors.forename: N
authors.initials: N
authors.lastname: Chen
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000737:chemistry; D010446:Peptide Fragments / Q000737:chemistry* / Q000494:pharmacology*; D030262:Soybean Proteins / Q000737:chemistry* / Q000494:pharmacology*; D013025:Glycine max / Q000737:chemistry
chemical_list: C120514:GM2S-1 protein, soybean; D009842:Oligopeptides; D010446:Peptide Fragments; D030262:Soybean Proteins; C047981:arginyl-glycyl-aspartic acid