title: The NTT transcription factor promotes replum development in Arabidopsis fruits.
abstract: Fruits are complex plant structures that nurture seeds and facilitate their dispersal. The Arabidopsis fruit is termed silique. It develops from the gynoecium, which has a stigma, a style, an ovary containing the ovules, and a gynophore. Externally, the ovary consists of two valves, and their margins lay adjacent to the replum, which is connected to the septum that internally divides the ovary. In this work we describe the role for the zinc-finger transcription factor NO TRANSMITTING TRACT (NTT) in replum development. NTT loss of function leads to reduced replum width and cell number, whereas increased expression promotes replum enlargement. NTT activates the homeobox gene BP, which, together with RPL, is important for replum development. In addition, the NTT protein is able to bind the BP promoter in yeast, and when this binding region is not present, NTT fails to activate BP in the replum. Furthermore, NTT interacts with itself and different proteins involved in fruit development: RPL, STM, FUL, SHP1 and SHP2 in yeast and in planta. Moreover, its genetic interactions provide further evidence about its biological relevance in replum development.
authors.affiliation: Departamento de Biotecnología y Bioquímica, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Km. 9.6 Libramiento Norte, Carretera Irapuato-León, A.P. 629, CP 36821 Irapuato, Guanajuato, Mexico.
authors.forename: Nayelli
authors.initials: N
authors.lastname: Marsch-Martínez
authors.forename: Víctor M
authors.initials: VM
authors.lastname: Zúñiga-Mayo
authors.forename: Humberto
authors.initials: H
authors.lastname: Herrera-Ubaldo
authors.forename: Pieter B F
authors.initials: PB
authors.lastname: Ouwerkerk
authors.forename: Jeanneth
authors.initials: J
authors.lastname: Pablo-Villa
authors.forename: Paulina
authors.initials: P
authors.lastname: Lozano-Sotomayor
authors.forename: Raffaella
authors.initials: R
authors.lastname: Greco
authors.forename: Patricia
authors.initials: P
authors.lastname: Ballester
authors.forename: Vicente
authors.initials: V
authors.lastname: Balanzá
authors.forename: Suzanne J H
authors.initials: SJ
authors.lastname: Kuijt
authors.forename: Annemarie H
authors.initials: AH
authors.lastname: Meijer
authors.forename: Andy
authors.initials: A
authors.lastname: Pereira
authors.forename: Cristina
authors.initials: C
authors.lastname: Ferrándiz
authors.forename: Stefan
authors.initials: S
authors.lastname: de Folter
mesh_terms: D017360:Arabidopsis / Q000166:cytology / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D029681:Arabidopsis Proteins / Q000235:genetics* / Q000378:metabolism; D005638:Fruit / Q000166:cytology / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D018506:Gene Expression Regulation, Plant; D017930:Genes, Reporter; D008954:Models, Biological; D009154:Mutation; D009928:Organ Specificity; D010641:Phenotype; D011401:Promoter Regions, Genetic / Q000235:genetics; D012639:Seeds / Q000166:cytology / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism; D016335:Zinc Fingers
chemical_list: D029681:Arabidopsis Proteins; C586527:At3g57670 protein, Arabidopsis; D014157:Transcription Factors
keywords: Arabidopsis thaliana; NO TRANSMITTING TRACT; fruit development; fruit patterning; replum; transcription factors