title: Ceftaroline Fosamil for Methicillin-Resistant Staphylococcus aureus Pulmonary Exacerbation in a Pediatric Cystic Fibrosis Patient.
abstract: Ceftaroline, an advanced generation cephalosporin with activity against methicillin-resistant Staphylococcus aureus (MRSA), may present a new therapeutic alternative for treating lung infections among patients with cystic fibrosis. We report a case of ceftaroline therapy in a pediatric patient with cystic fibrosis, whose dose was increased from 9.7 mg/kg/dose every 12 hours to 10.8 mg/kg/dose every 8 hours by using pharmacokinetic analyses.
authors.affiliation: Children's Hospital of Michigan, Detroit Medical Center, Detroit, Michigan.
authors.forename: Leah
authors.initials: L
authors.lastname: Molloy
authors.affiliation: Anti-Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan.
authors.forename: Ashley Hall
authors.initials: AH
authors.lastname: Snyder
authors.affiliation: Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan ; Division of Pulmonary Medicine, Wayne State University School of Medicine, Detroit, Michigan.
authors.forename: Ruma
authors.initials: R
authors.lastname: Srivastava
authors.affiliation: Anti-Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan ; Wayne State University School of Medicine, Detroit, Michigan.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Rybak
authors.affiliation: Children's Hospital of Michigan, Detroit Medical Center, Detroit, Michigan ; Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan ; Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, Michigan ; Wayne State University School of Medicine, Detroit, Michigan.
authors.forename: Eric
authors.initials: E
authors.lastname: McGrath
keywords: ceftaroline; cystic fibrosis; pediatrics; pharmacodynamics; pharmacokinetics