title: Contributions of tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase to the conversion of D-tryptophan to nicotinamide analyzed by using tryptophan 2,3-dioxygenase-knockout mice.
abstract: We investigated the contribution percentage of tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) to the conversion of D-tryptophan to nicotinamide in TDO-knockout mice. The calculated percentage conversions indicated that TDO and IDO oxidized 70 and 30%, respectively, of the dietary L-tryptophan. These results indicate that both TDO and IDO biosynthesize nicotinamide from D-tryptophan and L-tryptophan in mice.
authors.affiliation: a Department of Nutrition , School of Human Cultures, The University of Shiga Prefecture , Hikone , Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Maeta
authors.forename: Mitsue
authors.initials: M
authors.lastname: Sano
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Fukuwatari
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Funakoshi
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Nakamura
authors.forename: Katsumi
authors.initials: K
authors.lastname: Shibata
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D004435:Eating / Q000187:drug effects; D005260:Female; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D009536:Niacinamide / Q000096:biosynthesis / Q000378:metabolism*; D013237:Stereoisomerism; D014364:Tryptophan / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D014366:Tryptophan Oxygenase / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*
chemical_list: D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D009536:Niacinamide; D014364:Tryptophan; D014366:Tryptophan Oxygenase
keywords: biosynthesis; d-tryptophan; indoleamine 2,3-dioxygenase; nicotinamide; tryptophan 2,3-dioxygenase