title: Decreased expression of miR-204 is associated with poor prognosis in patients with breast cancer.
abstract: The identification of biomarkers in breast cancer diagnosis and therapy is important in achieving early cancer diagnosis and improving patient outcomes. The aim of this study was to examine clinical significance of miR-204 expression in tissues from breast cancer patients. The relationship between miR-204 expression and clinicopathological characteristics was investigated. MiR-204 expression was significantly associated with TNM stage and metastasis. Patients with low miR-204 expression had poorer overall survival time and disease free survival time than those with high miR-204 expression. Furthermore, miR-204 expression was correlated with chemotherapeutic resistance of breast cancer patients. In conclusion, the miR-204 may be a potential diagnostic and prognostic biomarker of breast cancer.
authors.affiliation: Department of Medical Oncology, Affiliated Cancer Hospital of Guangzhou Medical University; Cancer Center of Guangzhou Medical University (CCGMU) Guangzhou, China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Medical Oncology, Affiliated Cancer Hospital of Guangzhou Medical University; Cancer Center of Guangzhou Medical University (CCGMU) Guangzhou, China.
authors.forename: Xuejun
authors.initials: X
authors.lastname: Jin
authors.affiliation: Cancer Research Institution, Southern Medical University Guangzhou China.
authors.forename: Qianbing
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Radiotherapy, People's Hospital of Shanxi Province Taiyuan, China.
authors.forename: Gong
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Department of Medical Oncology, Affiliated Cancer Hospital of Guangzhou Medical University; Cancer Center of Guangzhou Medical University (CCGMU) Guangzhou, China.
authors.forename: Xubin
authors.initials: X
authors.lastname: Deng
authors.affiliation: Department of Medical Oncology, Affiliated Cancer Hospital of Guangzhou Medical University; Cancer Center of Guangzhou Medical University (CCGMU) Guangzhou, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Ma
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology*; D018572:Disease-Free Survival; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D035683:MicroRNAs / Q000096:biosynthesis*; D008875:Middle Aged; D011379:Prognosis; D060888:Real-Time Polymerase Chain Reaction
chemical_list: D014408:Biomarkers, Tumor; C549404:MIRN204 microRNA, human; D035683:MicroRNAs
keywords: MiR-204; breast cancer; prognosis