title: The effects of beta-glucan rich oat bread on serum nitric oxide and vascular endothelial function in patients with hypercholesterolemia.
abstract: BACKGROUND
  Oats are high in soluble fibers and effective in reducing the risk of cardiovascular diseases (CVD). We assessed the effects of beta-glucan from oat bran on serum nitric oxide (NO) endothelial function in patients with hypercholesterolemia.
  
  
  METHODS
  Sixty hypercholesterolemic patients were randomly divided to receive an experimental bread rich in beta-glucan from oat bran (intervention) or bread rich in wheat fiber (control) for four weeks. All subjects had the same diet for two-week baseline period and hypocaloric diet for four weeks of intervention. Serum NO concentration and flow-mediated dilation (FMD) were determined before and after the experiment.
  
  
  RESULTS
  Mean age of the participants was 51.1 ± 9.3 years and 65% (n = 39) were female. After intervention, serum NO concentration increased by 50.2 ± 19.8 μmol/lit in the intervention group (P = 0.017), but no change was observed in the control group (17.5 ± 27.5 μmol/lit; P = 0.530). No change of FMD was observed in the intervention (0.48 ± 0.78%; P = 0.546) or in the control group (0.59 ± 0.92%; P = 0.533).
  
  
  CONCLUSIONS
  Consumption of oat bread for four weeks increases serum NO concentration but has no effect on FMD. Further studies are warranted in this regard.
authors.affiliation: Medical Students' Research Center, Isfahan University of Medical Sciences, P.O. Box 81465-1148, Isfahan, Iran.
authors.forename: Faezeh
authors.initials: F
authors.lastname: Tabesh
authors.affiliation: Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Khorram Avenue, P.O. Box 81465-1148, Isfahan, Iran.
authors.forename: Hamid
authors.initials: H
authors.lastname: Sanei
authors.affiliation: Medical Students' Research Center, Isfahan University of Medical Sciences, P.O. Box 81465-1148, Isfahan, Iran.
authors.forename: Mansour
authors.initials: M
authors.lastname: Jahangiri
authors.affiliation: Department of Cardiology, Isfahan University of Medical Sciences, P.O. Box 81465-1148, Isfahan, Iran.
authors.forename: Amir
authors.initials: A
authors.lastname: Momenizadeh
authors.affiliation: Department of Internal Medicine, Isfahan University of Medical Sciences, P.O. Box 81465-1148, Isfahan, Iran.
authors.forename: Elham
authors.initials: E
authors.lastname: Tabesh
authors.affiliation: Department of Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Kiana
authors.initials: K
authors.lastname: Pourmohammadi
authors.affiliation: Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Khorram Avenue, P.O. Box 81465-1148, Isfahan, Iran.
authors.forename: Masoumeh
authors.initials: M
authors.lastname: Sadeghi
mesh_terms: D000328:Adult; D001939:Bread; D002784:Cholesterol / Q000097:blood / Q000134:cerebrospinal fluid; D004043:Dietary Fiber / Q000008:administration & dosage; D042783:Endothelial Cells / Q000187:drug effects* / Q000473:pathology; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood* / Q000150:complications / Q000178:diet therapy / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000178:diet therapy / Q000473:pathology; D047071:beta-Glucans / Q000008:administration & dosage
chemical_list: D004043:Dietary Fiber; D047071:beta-Glucans; D009569:Nitric Oxide; C067858:beta-glucan, (1-3)(1-4)-; D002784:Cholesterol