title: The Multiple Sclerosis Performance Test (MSPT): an iPad-based disability assessment tool.
abstract: Precise measurement of neurological and neuropsychological impairment and disability in multiple sclerosis is challenging. We report a new test, the Multiple Sclerosis Performance Test (MSPT), which represents a new approach to quantifying MS related disability. The MSPT takes advantage of advances in computer technology, information technology, biomechanics, and clinical measurement science. The resulting MSPT represents a computer-based platform for precise, valid measurement of MS severity. Based on, but extending the Multiple Sclerosis Functional Composite (MSFC), the MSPT provides precise, quantitative data on walking speed, balance, manual dexterity, visual function, and cognitive processing speed. The MSPT was tested by 51 MS patients and 49 healthy controls (HC). MSPT scores were highly reproducible, correlated strongly with technician-administered test scores, discriminated MS from HC and severe from mild MS, and correlated with patient reported outcomes. Measures of reliability, sensitivity, and clinical meaning for MSPT scores were favorable compared with technician-based testing. The MSPT is a potentially transformative approach for collecting MS disability outcome data for patient care and research. Because the testing is computer-based, test performance can be analyzed in traditional or novel ways and data can be directly entered into research or clinical databases. The MSPT could be widely disseminated to clinicians in practice settings who are not connected to clinical trial performance sites or who are practicing in rural settings, drastically improving access to clinical trials for clinicians and patients. The MSPT could be adapted to out of clinic settings, like the patient's home, thereby providing more meaningful real world data. The MSPT represents a new paradigm for neuroperformance testing. This method could have the same transformative effect on clinical care and research in MS as standardized computer-adapted testing has had in the education field, with clear potential to accelerate progress in clinical care and research.
authors.affiliation: Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation; rudickr@ccf.org.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Rudick
authors.affiliation: Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation.
authors.forename: Deborah
authors.initials: D
authors.lastname: Miller
authors.affiliation: Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation.
authors.forename: Francois
authors.initials: F
authors.lastname: Bethoux
authors.affiliation: Center for Brain Health, Cleveland Clinic Foundation.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Rao
authors.affiliation: Quantitative Health Sciences, Cleveland Clinic Foundation.
authors.forename: Jar-Chi
authors.initials: JC
authors.lastname: Lee
authors.affiliation: Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation.
authors.forename: Darlene
authors.initials: D
authors.lastname: Stough
authors.affiliation: Center for Brain Health, Cleveland Clinic Foundation.
authors.forename: Christine
authors.initials: C
authors.lastname: Reece
authors.affiliation: Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation.
authors.forename: David
authors.initials: D
authors.lastname: Schindler
authors.affiliation: Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation.
authors.forename: Bernadett
authors.initials: B
authors.lastname: Mamone
authors.affiliation: Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation.
authors.forename: Jay
authors.initials: J
authors.lastname: Alberts
mesh_terms: D034201:Computers, Handheld; D003936:Diagnosis, Computer-Assisted / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000503:physiopathology*