title: Chronic exposure to chlorophenol related compounds in the pesticide production workplace and lung cancer: a meta-analysis.
abstract: BACKGROUND
  Chlorophenols (CPs) and related phenoxyacetic acids (PAs) are pesticide groups contaminated with highly toxic 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) during production. PAs and CPs exposure is associated with risk of cancer, but the situation regarding lung cancer has not been clearly defined. We proposed a meta-analysis of published researches to evaluate relationship between chronic exposure to PAs and CPs in pesticide production workplaces and the risk of lung cancer.
  
  
  METHODS
  After searching PubMed, Scopus, Scholar Google, Web of Sciences until August 2013, the association between chronic PAs and CPs exposure in production workplace and lung cancer was studied in 15 cohort studies. The standardized mortality rate (SMR) and 95% confidence intervals (CI) were collected from the papers. We used random or fixed-effects models, Egger test, funnel plot and meta regression in our analysis.
  
  
  RESULTS
  Five papers with six reports were included in the final analysis. The standardized mortality rate for lung cancer from the random model was 1.18 (95% CI: 1.03-1.35, p=0.014) with moderate heterogeneity. Publication bias was not found for included studies in meta-analysis (p=0.9).
  
  
  CONCLUSIONS
  Our findings has strengthen the evidence of lung cancer from chronic exposure to chlorophenol related compounds (PAs, CPs).
authors.affiliation: Department of Occupational Hygiene, Faculty of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Irann E-mail : Rahimian.Raana@gmail.com.
authors.forename: Rezvan
authors.initials: R
authors.lastname: Zendehdel
authors.forename: Raana
authors.initials: R
authors.lastname: Tayefeh-Rahimian
authors.forename: Ali
authors.initials: A
authors.lastname: Kabir
mesh_terms: D000085:Acetates / Q000009:adverse effects; D016022:Case-Control Studies; D002733:Chlorophenols / Q000009:adverse effects*; D015331:Cohort Studies; D016001:Confidence Intervals; D003430:Cross-Sectional Studies; D004198:Disease Susceptibility / Q000139:chemically induced / Q000209:etiology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000209:etiology*; D008297:Male; D016273:Occupational Exposure / Q000009:adverse effects*; D010575:Pesticides / Q000009:adverse effects*; D012306:Risk; D017132:Workplace
chemical_list: D000085:Acetates; D002733:Chlorophenols; D010575:Pesticides; C415326:phenoxyacetic acid