title: Temporal unpredictability of a stimulus sequence affects brain activation differently depending on cognitive task demands.
abstract: Within cognitive neuroscience, in nearly every experimental setting, subjects are presented with stimuli that appear at either constant or variable points in time, referred to as interstimulus intervals (ISIs). These temporal patterns differ in the degree to which an exact stimulus onset may be predicted. We investigated whether this experimental feature affects brain and behavior, and whether the impact is modulated by the cognitive demands of a task. Subjects (N=26) were assessed via fMRI while solving three different tasks under either temporally predictable (constant ISI) or unpredictable (variable ISI) conditions. The tasks differed with regard to demands on working memory and response uncertainty. Compared to constant ISIs, variable (i.e., less predictable) ISIs led to a general increase in reaction time and in right amygdala activation. Depending on the cognitive demands required by the specific task, the left amygdala, the parietal cortex, the supplementary motor area, and the dorsolateral prefrontal cortex were engaged as well. The results indicate that the temporal structure in a stimulus sequence affects both overt and covert behaviors. Implicit temporal uncertainty increases activation in several brain regions depending on cognitive demands. Thus, an often-overlooked basic design feature, the application of constant or variable ISIs, may contribute to heterogeneity in cognitive neuroscience findings.
authors.affiliation: Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany; Centre for Psychiatry, Justus Liebig University Giessen, Giessen, Germany.
authors.forename: Georgia
authors.initials: G
authors.lastname: Koppe
authors.affiliation: Centre for Psychiatry, Justus Liebig University Giessen, Giessen, Germany.
authors.forename: Harald
authors.initials: H
authors.lastname: Gruppe
authors.affiliation: Centre for Psychiatry, Justus Liebig University Giessen, Giessen, Germany.
authors.forename: Gebhard
authors.initials: G
authors.lastname: Sammer
authors.affiliation: Centre for Psychiatry, Justus Liebig University Giessen, Giessen, Germany.
authors.forename: Bernd
authors.initials: B
authors.lastname: Gallhofer
authors.affiliation: Department of Clinical Psychology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Kirsch
authors.affiliation: Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany; Centre for Psychiatry, Justus Liebig University Giessen, Giessen, Germany. Electronic address: stefanie.lis@zi-mannheim.de.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Lis
mesh_terms: D000328:Adult; D000679:Amygdala / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D002540:Cerebral Cortex / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology*; D013997:Time Factors; D035501:Uncertainty; D055815:Young Adult
keywords: Amygdala; Interstimulus interval; N-Back; Response selection; Temporal unpredictability; Working memory