title: An unconventional BST-2 function: down-regulation of transient protein expression.
abstract: While viral inhibition by tethering of budding virions to host cell membranes has been focused upon as one of the main functions of BST-2/tetherin, BST-2 is thought to possess other functions as well. Overexpression of BST-2 was found here to down-regulate transient protein expression. Removal of the N- and C-terminal regions of BST-2, previously described to be involved in signal transduction, reduced the impact of BST-2. These results suggest that BST-2-mediated signaling may play a role in regulating the levels of transiently expressed proteins, highlighting a new function for BST-2 that may also have implications for viral inhibition.
authors.affiliation: Virology and Cell Technology Laboratory, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, 113 Thailand Science Park, Phaholyothin Rd, Klong 1, Klong Luang, Pathumthani 12120, Thailand.
authors.forename: Jaraspim
authors.initials: J
authors.lastname: Narkpuk
authors.affiliation: Virology and Cell Technology Laboratory, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, 113 Thailand Science Park, Phaholyothin Rd, Klong 1, Klong Luang, Pathumthani 12120, Thailand.
authors.forename: Asawin
authors.initials: A
authors.lastname: Wanitchang
authors.affiliation: Virology and Cell Technology Laboratory, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, 113 Thailand Science Park, Phaholyothin Rd, Klong 1, Klong Luang, Pathumthani 12120, Thailand.
authors.forename: Jarin
authors.initials: J
authors.lastname: Kramyu
authors.affiliation: Virology and Cell Technology Laboratory, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, 113 Thailand Science Park, Phaholyothin Rd, Klong 1, Klong Luang, Pathumthani 12120, Thailand.
authors.forename: Phanramphoei Namprachan
authors.initials: PN
authors.lastname: Frantz
authors.affiliation: Virology and Cell Technology Laboratory, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, 113 Thailand Science Park, Phaholyothin Rd, Klong 1, Klong Luang, Pathumthani 12120, Thailand.
authors.forename: Anan
authors.initials: A
authors.lastname: Jongkaewwattana
authors.affiliation: Virology and Cell Technology Laboratory, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, 113 Thailand Science Park, Phaholyothin Rd, Klong 1, Klong Luang, Pathumthani 12120, Thailand. Electronic address: samaporn.tee@biotec.or.th.
authors.forename: Samaporn
authors.initials: S
authors.lastname: Teeravechyan
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000235:genetics / Q000502:physiology*; D002460:Cell Line; D004285:Dogs; D015536:Down-Regulation; D058851:GPI-Linked Proteins / Q000235:genetics / Q000502:physiology; D057809:HEK293 Cells; D006801:Humans; D012333:RNA, Messenger / Q000235:genetics; D015398:Signal Transduction; D000074010:Bone Marrow Stromal Antigen 2
chemical_list: D015703:Antigens, CD; D058851:GPI-Linked Proteins; D012333:RNA, Messenger; C094572:BST2 protein, human; D000074010:Bone Marrow Stromal Antigen 2
keywords: BST-2; Influenza virus; Protein expression; Reverse genetics; Tetherin