title: Hair type-specific function of canonical Wnt activity in adult mouse skin.
abstract: Wnt/β-catenin signalling is a key regulator of hair follicle (HF) morphogenesis and life-long HF regeneration. In a recently published issue of Experimental Dermatology, Lei et al. report that sustained WNT10B supply and pathway activation in regenerating mouse HF increased the width of hair bulbs, hair shafts and the dermal papilla (DP), and enlarged the CD34(+) HF bulge cell compartment. Notably, WNT10B affected primarily zigzag HFs, while size and morphology of other HF types remained largely unaffected. Thus, these findings raise a number of questions regarding a HF type-specific function of Wnt/β-catenin and on the role of the WNT-stimulated DP in this process.
authors.affiliation: Medical Faculty, Center for Biochemistry, University of Cologne, Cologne, Germany; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.
authors.forename: Catherin
authors.initials: C
authors.lastname: Niemann
authors.forename: Marlon R
authors.initials: MR
authors.lastname: Schneider
mesh_terms: D000818:Animals; D018952:Antigens, CD34 / Q000378:metabolism; D018859:Hair Follicle / Q000033:anatomy & histology / Q000254:growth & development / Q000378:metabolism*; D051379:Mice; D009024:Morphogenesis; D051153:Wnt Proteins / Q000378:metabolism; D060449:Wnt Signaling Pathway; D051176:beta Catenin / Q000378:metabolism
chemical_list: D018952:Antigens, CD34; C495267:CTNNB1 protein, mouse; D051153:Wnt Proteins; C102068:Wnt10b protein, mouse; D051176:beta Catenin
keywords: Dickkopf 1; WNT10B; Wnt signalling; dermal papilla; hair follicle; hair type; β-catenin