title: Copper-mediated ortho-nitration of (hetero)arenecarboxylates.
abstract: Various (hetero)arenecarboxylic acids were converted to the corresponding Daugulis amides and nitrated selectively in the ortho-position in the presence of [CuNO3(PPh3)2] and AgNO2 at 50 °C. A microwave-assisted saponification allows regenerating the carboxylate group within minutes, which may then be removed tracelessly by protodecarboxylation, or substituted by aryl- or alkoxy-groups via decarboxylative cross-coupling.
authors.affiliation: FB Chemie-Organische Chemie, Technische Universität Kaiserslautern, Erwin-Schrödinger-Str. Geb. 54, 67663 Kaiserslautern (Germany), Fax: (+49) 631-205-3921.
authors.forename: Dmitry
authors.initials: D
authors.lastname: Katayev
authors.forename: Kai F
authors.initials: KF
authors.lastname: Pfister
authors.forename: Timo
authors.initials: T
authors.lastname: Wendling
authors.forename: Lukas J
authors.initials: LJ
authors.lastname: Gooßen
keywords: CH activation; carboxylic acids; copper; homogeneous catalysis; nitration