title: Can genetics improve precision of therapy in diabetes?
abstract: Diabetes mellitus is a lifelong, incapacitating disease affecting multiple organs. Presently, type 2 diabetes (T2D) can neither be prevented nor cured and the disease is associated with devastating chronic complications. These complications impose an immense burden on the quality of life of patients and account for about 12% of direct health care costs in Europe. Genetic analysis will increase our understanding of this heterogeneous disease and may help offer more personalized treatment.
authors.affiliation: Lund University Diabetes Centre, Department of Clinical Science, Lund University, 20502 Malmö, Sweden. Electronic address: Leif.Groop@med.lu.se.
authors.forename: Leif
authors.initials: L
authors.lastname: Groop
authors.affiliation: Lund University Diabetes Centre, Department of Clinical Science, Lund University, 20502 Malmö, Sweden.
authors.forename: Petter
authors.initials: P
authors.lastname: Storm
authors.affiliation: Lund University Diabetes Centre, Department of Clinical Science, Lund University, 20502 Malmö, Sweden.
authors.forename: Anders
authors.initials: A
authors.lastname: Rosengren
mesh_terms: D001682:Biological Availability; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism; D054873:Dipeptidyl-Peptidase IV Inhibitors / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D014644:Genetic Variation; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000627:therapeutic use; D007408:Intestinal Absorption; D008687:Metformin / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D010597:Pharmacogenetics / Q000379:methods*; D057285:Precision Medicine; D013453:Sulfonylurea Compounds / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D045162:Thiazolidinediones / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use
chemical_list: D054873:Dipeptidyl-Peptidase IV Inhibitors; D007004:Hypoglycemic Agents; D013453:Sulfonylurea Compounds; D045162:Thiazolidinediones; D008687:Metformin