title: Ranibizumab for the treatment of degenerative ocular conditions.
abstract: Degenerative ocular conditions, such as age-related macular degeneration, diabetic retinopathy, retinal vein occlusions, and myopic degeneration, have become a major public health problem and a leading cause of blindness in developed countries. Anti-vascular endothelial growth factor (VEGF) drugs seem to be an effective and safe treatment for these conditions. Ranibizumab, a humanized monoclonal antibody antigen-binding fragment, which inhibits all biologically active isoforms of VEGF-A, is still the gold standard treatment for the majority of these pathological entities. In this review, we present the results of the most important clinical trials concerning the efficacy and safety of ranibizumab for the treatment of degenerative ocular conditions.
authors.affiliation: Department of Ophthalmology, University General Hospital of Alexandroupolis, School of Medicine, University of Thrace, Alexandroupolis, Greece.
authors.forename: Magdalini
authors.initials: M
authors.lastname: Triantafylla
authors.affiliation: Department of Ophthalmology, Geneva University Hospitals, Faculty of Medicine, University of Geneva, Switzerland.
authors.forename: Horace F
authors.initials: HF
authors.lastname: Massa
authors.affiliation: Department of Ophthalmology, University General Hospital of Alexandroupolis, School of Medicine, University of Thrace, Alexandroupolis, Greece.
authors.forename: Doukas
authors.initials: D
authors.lastname: Dardabounis
authors.affiliation: Department of Ophthalmology, Geneva University Hospitals, Faculty of Medicine, University of Geneva, Switzerland.
authors.forename: Zisis
authors.initials: Z
authors.lastname: Gatzioufas
authors.affiliation: Department of Ophthalmology, University General Hospital of Alexandroupolis, School of Medicine, University of Thrace, Alexandroupolis, Greece.
authors.forename: Vassilios
authors.initials: V
authors.lastname: Kozobolis
authors.affiliation: Department of Ophthalmology, University General Hospital of Alexandroupolis, School of Medicine, University of Thrace, Alexandroupolis, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Ioannakis
authors.affiliation: Department of Ophthalmology, University General Hospital of Alexandroupolis, School of Medicine, University of Thrace, Alexandroupolis, Greece ; Beyoglou Eye Research and Teaching Hospital, Istanbul University, Istanbul, Turkey.
authors.forename: Irfan
authors.initials: I
authors.lastname: Perente
authors.affiliation: Department of Ophthalmology, University General Hospital of Alexandroupolis, School of Medicine, University of Thrace, Alexandroupolis, Greece ; Department of Ophthalmology, Geneva University Hospitals, Faculty of Medicine, University of Geneva, Switzerland.
authors.forename: Georgios D
authors.initials: GD
authors.lastname: Panos
keywords: age-related macular degeneration; anti-VEGF; diabetic macular edema; efficacy; quality of life; retinal vein occlusion; safety