title: Diastolic function assessed by cardiac MRI using longitudinal left ventricular fractional shortening.
abstract: BACKGROUND
  Diastolic dysfunction contributes significantly to diastolic heart failure. We examined the use of cardiac magnetic resonance imaging (CMR) using midwall longitudinal fractional shortening (MLFS) in the evaluation of transthoracic echocardiogram (TTE)-evidenced diastolic dysfunction.
  
  
  METHODS
  A total of 80 patients with CMR within 6 months of TTE and normal ejection fraction were identified. MLFS was calculated as percentage change in distance from the anterior mitral leaflet base to the apical endocardium in systole and diastole.
  
  
  RESULTS
  MLFS of grade II/III [0.14 (0.12-0.16)] was significantly lower than that of grade 0/I [0.20 (0.19-0.21)], P=.001. MLFS detected age-related changes with grade 0 [0.22 (0.21-0.23)] significantly lower than grade I [0.18 (0.16-0.20)], P=.001.
  
  
  CONCLUSIONS
  TTE-evidenced diastolic dysfunction can be reliably identified by CMR using MLFS.
authors.affiliation: Department of Radiology, University of California, San Francisco, USA.
authors.forename: Marie N
authors.initials: MN
authors.lastname: Dusch
authors.affiliation: Department of Radiology, University of California, San Francisco, USA.
authors.forename: Samir R
authors.initials: SR
authors.lastname: Thadani
authors.affiliation: Department of Radiology, University of California, San Francisco, USA.
authors.forename: Gupreet S
authors.initials: GS
authors.lastname: Dhillon
authors.affiliation: Department of Radiology, University of California, San Francisco, USA. Electronic address: michael.hope@ucsf.edu.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Hope
mesh_terms: D000328:Adult; D003971:Diastole; D005260:Female; D005500:Follow-Up Studies; D006352:Heart Ventricles / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013318:Stroke Volume; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000503:physiopathology; D016277:Ventricular Function, Left / Q000502:physiology*
keywords: Cardiac magnetic resonance imaging; Diastolic dysfunction; Diastolic heart failure; Longitudinal midwall shortening; Transthoracic echocardiography