title: Cowden syndrome--a case report emphasizing the role of the dental surgeon in diagnosis.
abstract: Cowden syndrome or multiple hamartoma syndrome, is a rare genetic condition inherited in an autosomal dominant pattern characterized by cutaneous manifestations, polyps, thyroid gland neoplasias, and macrocephaly. This report presents the case of a 36-year-old patient who looked for dental treatment for a gingival nodule. Current and past medical history and oral and facial manifestations led to the diagnosis of Cowden syndrome. This case report emphasizes the role of the dental surgeon in the diagnosis of this systemic disease, based on the analysis of medical history and manifestations in the oral cavity.
authors.affiliation: Master degree student, Department of Oral Pathology, School of Dentistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Liana Preto
authors.initials: LP
authors.lastname: Webber
authors.forename: Manoela Domingues
authors.initials: MD
authors.lastname: Martins
authors.forename: Vinícius Coelho
authors.initials: VC
authors.lastname: Carrard
authors.forename: Marco Antônio
authors.initials: MA
authors.lastname: Trevizani Martins
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Munerato
mesh_terms: D000328:Adult; D001706:Biopsy; D001938:Brazil; D003937:Diagnosis, Differential; D003945:Diagnosis, Oral; D005260:Female; D006223:Hamartoma Syndrome, Multiple / Q000175:diagnosis*; D006801:Humans
keywords: Cowden disease; PTEN; genetics; hamartoma tumor syndrome; oral papules; trichilemmomas