title: Extra sensory perception: the role of Gpr receptors in the kidney.
abstract: OBJECTIVE
  This review will summarize recent literature highlighting the roles of sensory Gpr receptors and their roles in renal function.
  
  
  RESULTS
  Chemoreceptors play important roles in renal physiology wherein they modulate renal function in response to ligands from a variety of sources.
  
  
  CONCLUSIONS
  As specialized chemical detectors, chemoreceptors in the kidney monitor the level of a variety of chemical ligands in the body and adjust renal function accordingly. In addition to olfactory receptors and taste receptors, G-protein coupled receptors of the orphan Gpr family are now being found to play a 'sensory' role in renal physiology. Identifying the physiological roles of these receptors and elucidating the cell biology underlying these signaling pathways can give us novel insights into renal function.
authors.affiliation: Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Pluznick
mesh_terms: D000818:Animals; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D008024:Ligands; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D012677:Sensation; D011984:Sensory Receptor Cells / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D008024:Ligands; D043562:Receptors, G-Protein-Coupled