title: Further evidence for the topography and connectivity of the corpus callosum: an FMRI study of patients with partial callosal resection.
abstract: OBJECTIVE
  This functional MRI study was designed to describe activated fiber topography and trajectories in the corpus callosum (CC) of six patients carrying different degree of partial callosal resection.
  
  
  METHODS
  Patients receiving gustatory, tactile, and visual stimulation according to a block-design protocol were scanned in a 1.5 Tesla magnet. Diffusion tensor imaging (DTI) data were also acquired to visualize spared interhemispheric fibers.
  
  
  RESULTS
  Taste stimuli evoked bilateral activation of the primary gustatory area in all patients and foci in the anterior CC, when spared. Tactile stimuli to the hand evoked bilateral foci in the primary somatosensory area in patients with an intact posterior callosal body and only contralateral in the other patients. Callosal foci occurred in the CC body, if spared. In patients with an intact splenium central visual stimulation induced bilateral activation of the primary visual area as well as foci in the splenium itself.
  
  
  CONCLUSIONS
  Present data show that interhemispheric fibers linking sensory areas crossed through the CC at the sites where the different sensory stimuli evoked activation foci, and that topography of callosal foci evoked by sensory stimulation in spared CC portions is consistent with that previously observed in subjects with intact CC.
authors.affiliation: Dipartimento di Scienze Cliniche Specialistiche e Odontostomatologiche, Università Politecnica delle Marche, Ancona, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Polonara
authors.forename: G
authors.initials: G
authors.lastname: Mascioli
authors.forename: N
authors.initials: N
authors.lastname: Foschi
authors.forename: U
authors.initials: U
authors.lastname: Salvolini
authors.forename: C
authors.initials: C
authors.lastname: Pierpaoli
authors.forename: T
authors.initials: T
authors.lastname: Manzoni
authors.forename: M
authors.initials: M
authors.lastname: Fabri
authors.forename: P
authors.initials: P
authors.lastname: Barbaresi
mesh_terms: D000328:Adult; D063132:Connectome / Q000379:methods*; D003337:Corpus Callosum / Q000033:anatomy & histology* / Q000502:physiology* / Q000601:surgery; D019317:Evidence-Based Medicine; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000033:anatomy & histology* / Q000503:physiopathology*; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult
keywords: Callosal commissure; DTI; functional brain imaging; interhemispheric transfer; split-brain patients