title: Direct trifluoromethylthiolation of alcohols under mild reaction conditions: conversion of R-OH into R-SCF3.
abstract: A direct process for the trifluoromethylthiolation of allylic and benzylic alcohols under mild conditions has been developed. A wide range of free alcohols underwent nucleophilic substitution in the presence of stable CuSCF3 and BF3 ⋅Et2O to give the corresponding products in good to excellent yields.
authors.affiliation: Institute of Organic Chemistry, Institution RWTH Aachen University, Landoltweg 1, 52074 Aachen (Germany).
authors.forename: Pavlo
authors.initials: P
authors.lastname: Nikolaienko
authors.forename: Roman
authors.initials: R
authors.lastname: Pluta
authors.forename: Magnus
authors.initials: M
authors.lastname: Rueping
keywords: alcohols; nucleophilic substitution; thioethers; trifluoromethyl sulfenylation