title: Structural insights into the human metapneumovirus glycoprotein ectodomain.
abstract: Human metapneumovirus is a major cause of respiratory tract infections worldwide. Previous reports have shown that the viral attachment glycoprotein (G) modulates innate and adaptive immune responses, leading to incomplete immunity and promoting reinfection. Using bioinformatics analyses, static light scattering, and small-angle X-ray scattering, we show that the extracellular region of G behaves as a heavily glycosylated, intrinsically disordered polymer. We discuss potential implications of these findings for the modulation of immune responses by G.
authors.affiliation: Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
authors.forename: Cedric
authors.initials: C
authors.lastname: Leyrat
authors.affiliation: Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
authors.forename: Guido C
authors.initials: GC
authors.lastname: Paesen
authors.affiliation: Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
authors.forename: James
authors.initials: J
authors.lastname: Charleston
authors.affiliation: Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
authors.forename: Max
authors.initials: M
authors.lastname: Renner
authors.affiliation: Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom Diamond Light Source Ltd., Diamond House, Harwell Science and Innovation Campus, Didcot, Oxfordshire, United Kingdom jonathan@strubi.ox.ac.uk.
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Grimes
mesh_terms: D006023:Glycoproteins / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism; D006031:Glycosylation; D006801:Humans; D007113:Immunity, Innate; D029121:Metapneumovirus / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism; D008958:Models, Molecular; D017434:Protein Structure, Tertiary; D014764:Viral Proteins / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism
chemical_list: C484233:G glycoprotein, human metapneumovirus; D006023:Glycoproteins; D014764:Viral Proteins