title: Influence of follicle rupture and uterine contractions on intrauterine insemination outcome: a new predictive model.
abstract: OBJECTIVE
  To correlate the detection of follicle rupture and the number of uterine contractions per minute with the outcome of IUI and to build a predictive model for the outcome of IUI including these parameters.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  Fertility clinic.
  
  
  METHODS
  We analyzed data from 610 women who underwent homologous or donor double IUI from 2005 to 2010 and whose data of uterine contractions or follicle rupture were recorded.
  
  
  METHODS
  None.
  
  
  METHODS
  Live-birth rate.
  
  
  RESULTS
  Nine hundred seventy-nine IUI cycles were included. The detection of follicle rupture (odds ratio [OR], 1.98; 95% confidence interval [CI], 1.30-3.01) and the number of uterine contractions per minute (OR, 1.67; 95% CI, 1.02-2.74) assessed after the second insemination procedure of a double IUI were positively correlated with the live-birth rate. A multiple logistic regression model showed that sperm origin, maternal age, follicle count at hCG administration day, follicle rupture, and the number of uterine contractions observed after the second insemination procedure were significantly associated with the live-birth rate.
  
  
  CONCLUSIONS
  Follicle rupture and uterine contractions are associated with the success of an IUI cycle. This may open new possibilities to improve the methodology of IUI.
authors.affiliation: IVI Seville, Seville, Spain.
authors.forename: Víctor
authors.initials: V
authors.lastname: Blasco
authors.affiliation: IVI Seville, Seville, Spain; Pablo de Olavide University, Seville, Spain.
authors.forename: Nicolás
authors.initials: N
authors.lastname: Prados
authors.affiliation: IVI Seville, Seville, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Carranza
authors.affiliation: IVI Seville, Seville, Spain; Pablo de Olavide University, Seville, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: González-Ravina
authors.affiliation: Instituto Valenciano de Infertilidad (IVI), Valencia, Spain; University of Valencia, Valencia, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Pellicer
authors.affiliation: IVI Seville, Seville, Spain. Electronic address: manuel.fernandez@ivi.es.
authors.forename: Manuel
authors.initials: M
authors.lastname: Fernández-Sánchez
mesh_terms: D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007316:Insemination, Artificial, Heterologous / Q000009:adverse effects; D007317:Insemination, Artificial, Homologous / Q000009:adverse effects; D050498:Live Birth; D016015:Logistic Models; D015233:Models, Statistical; D015999:Multivariate Analysis; D016017:Odds Ratio; D006080:Ovarian Follicle / Q000502:physiology*; D010060:Ovulation; D011247:Pregnancy; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D014590:Uterine Contraction
keywords: Intrauterine insemination; clinical pregnancy rate; follicle rupture; live-birth rate; predictive model; uterine contraction