title: Synthesis and pharmacokinetic characterization of a pH-sensitive polyethylene glycol ginsenoside CK (PEG-CK) conjugate.
abstract: The ginsenosides in Panax ginseng have vast structural and pharmacological efficacies. We covalently conjugated polyethylene glycol on the surface of CK (PEG-CK) through an acid-labile ester-linkage that showed increased solubility of CK. HPLC analysis showed that the release of CK was enhanced at acidic pH 5, whereas it was dramatically decreased at physiological pH 7.4. This might enhance the efficacy of CK.
authors.affiliation: a Graduate School of Biotechnology and Ginseng Bank, College of Life Sciences, Kyung Hee University , Yongin , Republic of Korea.
authors.forename: Ramya
authors.initials: R
authors.lastname: Mathiyalagan
authors.forename: Sathiyamoorthy
authors.initials: S
authors.lastname: Subramaniyam
authors.forename: Yeon Ju
authors.initials: YJ
authors.lastname: Kim
authors.forename: Sathishkumar
authors.initials: S
authors.lastname: Natarajan
authors.forename: Jin Woo
authors.initials: JW
authors.lastname: Min
authors.forename: Se Young
authors.initials: SY
authors.lastname: Kim
authors.forename: Deok Chun
authors.initials: DC
authors.lastname: Yang
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004952:Esters / Q000737:chemistry; D036145:Ginsenosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D006863:Hydrogen-Ion Concentration; D005894:Panax / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000737:chemistry; D013499:Surface Properties
chemical_list: D004952:Esters; D036145:Ginsenosides; D011092:Polyethylene Glycols
keywords: Panax ginseng; cancer; compound k; polyethylene glycol; solubility