title: A possible role for IL-17A in establishing Th2 inflammation in murine models of atopic dermatitis.
abstract: Atopic dermatitis (AD) is associated with the effects of T helper type 2 (Th2) and Th22 cytokines. Recent studies, however, have also implicated Th17 in acute AD. Functional studies of Th2 and Th22 cytokines revealed their roles in generating molecular changes during AD; IL-17A's role, however, has yet to be defined. The report by Nakajima et al. (this issue) begins to define that role by demonstrating IL-17A's ability to induce Th2 inflammation in acute disease.
authors.affiliation: The Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, USA; Columbia University College of Physicians and Surgeons, New York, New York, USA.
authors.forename: Nikhil
authors.initials: N
authors.lastname: Dhingra
authors.affiliation: The Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, USA; Department of Dermatology, Icahn School of Medicine at Mount Sinai Medical Center, New York, New York, USA. Electronic address: eguttman@rockefeller.edu.
authors.forename: Emma
authors.initials: E
authors.lastname: Guttman-Yassky
mesh_terms: D000818:Animals; D003876:Dermatitis, Atopic / Q000276:immunology*; D020381:Interleukin-17 / Q000502:physiology*; D018418:Th2 Cells / Q000276:immunology*
chemical_list: D020381:Interleukin-17