title: Effects of aqueous soybean, mistletoe and red clover extracts on activities of adenosine deaminase and xanthine oxidase enzyme.
abstract: Soybean (Glycine max), mistletoe (Viscum album) and red clover (Trifolium pratence) have been argued to have anti-cancer effects. In the present study it was aimed to investigate possible effects of these plant extracts on the activities of DNA turn-over enzymes, namely adenosine deaminase (ADA) and xanthine oxidase (XO) in cancerous and non-cancerous gastric and colon tissues. For this aim, 6 cancerous and 6 non-cancerous adjacent human gastric tissues, and 7 cancerous and 7 non-cancerous adjacent colon tissues were obtained by surgical operations. Our results suggest that aqueous soybean, mistletoe and red clover extracts may exhibit anti-tumoral activity by depleting hypoxanthine concentration in the cancer cells through XO activation, which may lead to lowered salvage pathway activity necessary for the cancer cells to proliferate in the cancerous colon tissue. Some foods like soybean, mistletoe and red clover may provide nutritional support to medical cancer therapy through inhibiting and/or activating key enzymes in cancer metabolism (Tab. 4, Ref. 33).
authors.forename: M
authors.initials: M
authors.lastname: Namuslu
authors.forename: H
authors.initials: H
authors.lastname: Kocaoglu
authors.forename: H T
authors.initials: HT
authors.lastname: Celik
authors.forename: A
authors.initials: A
authors.lastname: Avci
authors.forename: E
authors.initials: E
authors.lastname: Devrim
authors.forename: Y
authors.initials: Y
authors.lastname: Genc
authors.forename: E
authors.initials: E
authors.lastname: Gocmen
authors.forename: I B
authors.initials: IB
authors.lastname: Erguder
authors.forename: I
authors.initials: I
authors.lastname: Durak
mesh_terms: D000243:Adenosine Deaminase / Q000187:drug effects* / Q000378:metabolism; D005770:Gastrointestinal Neoplasms / Q000201:enzymology* / Q000473:pathology; D006801:Humans; D014784:Mistletoe; D010936:Plant Extracts / Q000494:pharmacology; D013025:Glycine max; D046509:Tissue Culture Techniques; D029921:Trifolium; D014969:Xanthine Oxidase / Q000187:drug effects* / Q000378:metabolism
chemical_list: D010936:Plant Extracts; D014969:Xanthine Oxidase; D000243:Adenosine Deaminase