title: [Mechanisms of resistance to molecular targeted drugs].
abstract: Cancer treatments have gradually improved during past decades. However, we are still facing problems to surmount in prevention and therapy of cancers. Recent advances in molecular-based understanding of cell proliferation and survival have provided the rationale for the molecular targeted therapy to control cancer. Contrary to our expectation, molecular targeted drugs, such as EGFR-, ALK-, ROS1-, or BRAF-targeted drugs, could not exhibit sufficient curative effects. This review aims to provide an overview of the recent progress in the development of kinase-targeted drugs and the analysis of the molecular mechanisms of pre-existent (intrinsic) and acquired drug resistance.
authors.forename: Naoya
authors.initials: N
authors.lastname: Fujita
mesh_terms: D019008:Drug Resistance, Neoplasm; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy*; D010770:Phosphotransferases / Q000037:antagonists & inhibitors*
chemical_list: D010770:Phosphotransferases