title: Intestinal decontamination of multidrug-resistant Klebsiella pneumoniae after recurrent infections in an immunocompromised host.
abstract: Multidrug-resistant (MDR) Enterobacteriaceae infections are associated with increased morbidity. We describe a 20-year-old hematopoietic cell transplantation recipient with recurrent MDR Klebsiella pneumoniae infection, prolonged intestinal colonization, and subsequent intestinal decontamination. Further study should evaluate stool surveillance, molecular typing, and fecal microbiota transplantation for patients with intestinal MDR Enterobacteriaceae carriage.
authors.affiliation: Department of Pediatrics, University of Washington, Seattle, WA, USA; Division of Infectious Diseases, University of Washington, Seattle, WA, USA; Center for Clinical and Translational Research, Seattle Children's Hospital Research Institute, Seattle, WA, USA. Electronic address: matthew.kronman@seattlechildrens.org.
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Kronman
authors.affiliation: Department of Pediatrics, University of Washington, Seattle, WA, USA; Division of Infectious Diseases, University of Washington, Seattle, WA, USA; Center for Clinical and Translational Research, Seattle Children's Hospital Research Institute, Seattle, WA, USA.
authors.forename: Danielle M
authors.initials: DM
authors.lastname: Zerr
authors.affiliation: Microbiology laboratory, Seattle Children's Hospital, Seattle, WA, USA; Department of Laboratory Medicine, University of Washington, Seattle, WA, USA.
authors.forename: Xuan
authors.initials: X
authors.lastname: Qin
authors.affiliation: Department of Pediatrics, University of Washington, Seattle, WA, USA; Division of Infectious Diseases, University of Washington, Seattle, WA, USA; Center for Clinical and Translational Research, Seattle Children's Hospital Research Institute, Seattle, WA, USA.
authors.forename: Janet
authors.initials: J
authors.lastname: Englund
authors.affiliation: Division of Infectious Diseases, University of Washington, Seattle, WA, USA.
authors.forename: Cathy
authors.initials: C
authors.lastname: Cornell
authors.affiliation: Division of Hematology/Oncology, Department of Pediatrics, University of Washington, Seattle, WA, USA; Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
authors.forename: Jean E
authors.initials: JE
authors.lastname: Sanders
authors.affiliation: Center for Childhood Infections and Prematurity Research, Seattle Children's Hospital Research Institute, Seattle, WA, USA.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Myers
authors.affiliation: Center for Childhood Infections and Prematurity Research, Seattle Children's Hospital Research Institute, Seattle, WA, USA.
authors.forename: Jaipreet
authors.initials: J
authors.lastname: Rayar
authors.affiliation: Center for Clinical and Translational Research, Seattle Children's Hospital Research Institute, Seattle, WA, USA.
authors.forename: Jessica E
authors.initials: JE
authors.lastname: Berry
authors.affiliation: Center for Clinical and Translational Research, Seattle Children's Hospital Research Institute, Seattle, WA, USA.
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Adler
authors.affiliation: Department of Pediatrics, University of Washington, Seattle, WA, USA; Division of Infectious Diseases, University of Washington, Seattle, WA, USA.
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Weissman
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D016470:Bacteremia / Q000188:drug therapy / Q000382:microbiology; D024901:Drug Resistance, Multiple, Bacterial; D005243:Feces / Q000382:microbiology; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016867:Immunocompromised Host; D007710:Klebsiella Infections / Q000188:drug therapy / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000145:classification / Q000187:drug effects* / Q000235:genetics; D008297:Male; D012008:Recurrence; D017192:Skin Diseases, Bacterial / Q000188:drug therapy / Q000382:microbiology; D066027:Transplant Recipients; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents
keywords: Hematopoietic cell transplantation; Intestinal decontamination; Klebsiella pneumoniae; Pediatrics; Resistance