title: Distinct roles of homeoproteins in brain topographic mapping and in neural circuit formation.
abstract: The construction of the brain is a highly regulated process, requiring coordination of various cellular and molecular mechanisms that together ensure the stability of the cerebrum architecture and functions. The mature brain is an organ that performs complex computational operations using specific sensory information from the outside world and this requires precise organization within sensory networks and a separation of sensory modalities during development. We review here the role of homeoproteins in the arealization of the brain according to sensorimotor functions, the micropartition of its cytoarchitecture, and the maturation of its sensory circuitry. One of the most interesting observation about homeoproteins in recent years concerns their ability to act both in a cell-autonomous and non-cell-autonomous manner. The highlights in the present review collectively show how these two modes of action of homeoproteins confer various functions in shaping cortical maps.
authors.affiliation: Laboratoire CRRET EAC 7149, Université Paris-Est Créteil, 61, Av. du Général de Gaulle, 94010 Créteil Cedex, France. Electronic address: olivier.stettler@u-pec.fr.
authors.forename: Olivier
authors.initials: O
authors.lastname: Stettler
authors.affiliation: Collège de France, Center for Interdisciplinary Research in Biology, UMR CNRS 7241/INSERM U1050, 11 place Marcelin Berthelot, 75005 Paris, France; Labex Memolife, PSL Research University, France.
authors.forename: Kenneth L
authors.initials: KL
authors.lastname: Moya
mesh_terms: D000818:Animals; D001921:Brain / Q000196:embryology / Q000254:growth & development / Q000502:physiology*; D001931:Brain Mapping; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D008959:Models, Neurological; D009434:Neural Pathways / Q000196:embryology / Q000254:growth & development / Q000502:physiology*; D013003:Somatosensory Cortex / Q000196:embryology / Q000254:growth & development / Q000502:physiology; D014793:Visual Cortex / Q000196:embryology / Q000254:growth & development / Q000502:physiology*; D014795:Visual Pathways / Q000196:embryology / Q000254:growth & development / Q000502:physiology
chemical_list: D018398:Homeodomain Proteins
keywords: Barrel field; Cortical regionalisation; Engrailed; Homeoproteins; Otx2; Retino-tectal