title: Formulation and evaluation of suspensions: mefenamic acid prodrugs.
abstract: Gastrosparing novel prodrugs (MAM and MAT) synthesized consisted of mefenamic acid (MA) with menthol (M) and thymol (T). Structural characterizations of synthesized esters were done by Infra red spectroscopy (IR), proton nuclear magnetic resonance (1HNMR), mass spectroscopy. After evaluation of pharmacological i.e. anti-inflammatory, analgesic and ulcerogenic activities, the preformulation studies were undertaken. Based on these a few formulation (suspensions) were designed and prepared. The formulated suspensions were evaluated for content uniformity, sedimentation volume, recovery studies, redispersibility, viscosity, pH, particle size, zeta potential, effect of temperature and in-vitro dissolution rate. All the above parameters were found to be within the limit these indicated that the synthesized esters are good candidate for liquid dosage form. Thus it can be concluded synthesized prodrugs can be formulated in suspension form.
authors.affiliation: Institute of Pharmaceutical Research, GLA University, Mathura, UP, India.
authors.forename: Kamal
authors.initials: K
authors.lastname: Shah
authors.affiliation: Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University, Varanasi UP, India.
authors.forename: Sushant K
authors.initials: SK
authors.lastname: Shrivastava
authors.forename: Pradeep
authors.initials: P
authors.lastname: Mishra
mesh_terms: D002626:Chemistry, Pharmaceutical; D006863:Hydrogen-Ion Concentration; D008528:Mefenamic Acid / Q000737:chemistry*; D011355:Prodrugs / Q000737:chemistry*; D012995:Solubility; D013535:Suspensions
chemical_list: D011355:Prodrugs; D013535:Suspensions; D008528:Mefenamic Acid