title: Post-mortem analysis of Candida albicans breakthrough infection during echinocandin treatment in haematopoietic stem cell transplant recipient.
abstract: We present case of a girl deceased due to Candida albicans breakthrough invasive infection during the echinocandin treatment after undergoing allogeneic haematopoietic stem cell transplant for relaps of acute myeloid leukaemia. Candida albicans generally susceptible to all antifungal drugs wasn't considered for potential resistance and conventional blood culture positivity was too late to reveal the resistance to echinocandins. Due to severe organ toxicities (liver, kidneys) she received echinocandin as an antifungal prophylaxis, no change was made for the treatment of Candida albicans infection. Later, the molecular analysis proved the mutation S645P known as being responsible for the echinocandin resistance. The post mortem analysis of fungal burden in autopsy samples showed very high levels of Candida DNA in gut, liver, spleen and kidneys.
authors.forename: V
authors.initials: V
authors.lastname: Chrenkova
authors.forename: P
authors.initials: P
authors.lastname: Hubacek
authors.forename: P
authors.initials: P
authors.lastname: Sedlacek
authors.forename: P
authors.initials: P
authors.lastname: Riha
authors.forename: D
authors.initials: D
authors.lastname: Kodetová
authors.forename: E
authors.initials: E
authors.lastname: Bébrová
mesh_terms: D000293:Adolescent; D000935:Antifungal Agents / Q000627:therapeutic use*; D002176:Candida albicans / Q000302:isolation & purification*; D002177:Candidiasis / Q000453:epidemiology*; D025141:Drug Resistance, Fungal; D054714:Echinocandins / Q000627:therapeutic use*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins