title: Reproductive endocrinology: functional effects of sex hormone-binding globulin variants.
abstract: A new study has found eight single nucleotide polymorphisms in sex hormone-binding globulin that functionally affect its affinity for androgens or estrogens and other biochemical properties. This finding adds to growing concern about the ‘one size fits all’ approach in formulas to calculate free or bioavailable concentrations of estradiol and testosterone.
authors.affiliation: Laboratory of Molecular Endocrinology, Gerontology and Geriatrics, KU Leuven and University Hospitals Leuven, Herestraat 49 PO Box 902, 3000 Leuven, Belgium.
authors.forename: Michaël R
authors.initials: MR
authors.lastname: Laurent
authors.affiliation: Clinical and Experimental Endocrinology, KU Leuven and University Hospitals Leuven, Herestraat 49 PO Box 902, 3000 Leuven, Belgium.
authors.forename: Dirk
authors.initials: D
authors.lastname: Vanderschueren
mesh_terms: D004958:Estradiol / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*; D013739:Testosterone / Q000097:blood*
chemical_list: D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D004958:Estradiol