title: [Influence of particle sizes and content of effective compositions of Panax notoginseng powders crashing by superfine somminution technique].
abstract: In this study, superfine comminution technique was applied to destroy the cell wall of the Panax notoginseng, and then the influence of the particle sizes and the content of effective composition of the P. notoginseng powders were learned, comparing with the common powders. Superfine comminution technique was used for 0.5, 1, 1.5, 2 h, respectively and the particle sizes, unifirmity were regarded as the evaluation index. Then, the sizes of the powders was measured that were crashed with different time by Malvern Mastersizer 2000 + Scricco 2000 and the total content of ginsenoside Rg1, ginsenoside Rb1, notoginsenoside R1 in the superfine powder of P. notoginseng were determined by HPLC-ELSD. Finally, the powder that crashed for two hours possess the more uniform in sizes that is at cell level, D50 is about 9.599 microm, the size distribution was presented as one peak, the other three samples were two peaks. The total content of the three saponins in the four samples that crashed for 0.5, 1, 1.5, 2 h by superfine comminution technique were 7.7%, 7.5%, 7.5%, 8.3%. However, the total content of the three ingredients in the common powder was 5.0%. This investigation indicated that superfine comminution technique has remarkable effect on particle size and uniformity of the common powder of P. notoginseng. By comparing the superfine powder and common powder, it was found that the method obviously improved the total content of the saponins and provided a basis for reducing dosage of notoginseng in clinical application, but the content and the crashed time were not the linear relationship. The crashed time can be chosen by combining with the demand partical sizes in the production.
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Wang
authors.forename: Yu-Ling
authors.initials: YL
authors.lastname: Liu
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Yang
authors.forename: Ya
authors.initials: Y
authors.lastname: Xu
authors.forename: Li
authors.initials: L
authors.lastname: Zhao
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Li
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D053723:Panax notoginseng / Q000737:chemistry*; D010316:Particle Size; D011208:Powders / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal; D011208:Powders