title: High Factor VIII and Von Willebrand Factor Levels Are Not Risk Factors of Cryptogenic Arterial Ischemic Stroke in Thai Children.
abstract: High factor VIII levels and a risk factor of arterial ischemic stroke is controversial. Levels of factor VIII depend on ethnicity, age, and sex. This report included 24 Thai children with cryptogenic arterial ischemic stroke and 41 controls, with a mean (standard deviation) age of 11.5 (6.3) and 9.0 (4.7), respectively. The study was performed during the post-arterial ischemic stroke events to avoid acute phase reaction of factor VIII and von Willebrand factor. The levels of factor VIII activity and von Willebrand factor antigen in patients were not significantly different compared to controls (119.8 ± 41.3% vs 138.0 ± 48.7%, P = .29 and 92.8 ± 29.8% vs 103.7 ± 39.1%, P = .4, respectively). Therefore, high factor VIII and von Willebrand factor antigen levels were not risk factors of cryptogenic arterial ischemic stroke in Thai children.
authors.affiliation: Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand nongnuch.sir@mahidol.ac.th.
authors.forename: Nongnuch
authors.initials: N
authors.lastname: Sirachainan
authors.affiliation: Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Manasjitt
authors.initials: M
authors.lastname: Boonyatarp
authors.affiliation: Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Praguywan
authors.initials: P
authors.lastname: Kadegasem
authors.affiliation: Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Werasak
authors.initials: W
authors.lastname: Sasanakul
authors.affiliation: Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Anannit
authors.initials: A
authors.lastname: Visudtibhan
authors.affiliation: Faculty of Medicine Chiang Mai University, Chiang Mai, Thailand.
authors.forename: Rungrote
authors.initials: R
authors.lastname: Natesirinilkul
authors.affiliation: Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Ampaiwan
authors.initials: A
authors.lastname: Chuansumrit
authors.affiliation: Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Pakawan
authors.initials: P
authors.lastname: Wongwerawattanakoon
mesh_terms: D000293:Adolescent; D001157:Arterial Occlusive Diseases / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D005169:Factor VIII / Q000378:metabolism*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012189:Retrospective Studies; D020521:Stroke / Q000097:blood* / Q000175:diagnosis / Q000209:etiology*; D013785:Thailand / Q000453:epidemiology; D014057:Tomography, X-Ray Computed; D014841:von Willebrand Factor / Q000378:metabolism*
chemical_list: D014841:von Willebrand Factor; D005169:Factor VIII
keywords: arterial ischemic stroke; factor VIII; von Willebrand factor