title: Sorption of norfloxacin in soils: analytical method, kinetics and Freundlich isotherms.
abstract: Fluoroquinolones are potent antibacterial agents that are active against a wide range of pathogenic organisms and are widely used in veterinary medicine. Fluoroquinolones and their metabolites may reach the soil through animal excreta or manure and may contaminate water and soils. The degree of sorption of these antimicrobials to soils varies widely, as does the mobility of these drugs. In the present study, sorption of norfloxacin in four soils of the state of São Paulo was investigated with batch equilibrium experiments. A strong matrix effect on the chromatographic determination of norfloxacin was verified. Sorption kinetics were best fit by a pseudo second-order model (r>0.99), and sorption/desorption isotherms were well fit by the Freundlich model in log form (r>0.97). Norfloxacin showed high affinity for soil particles, with KF sorption values ranging from 643 to 2410 μg(1-1/n)(cm(3))(1/n)g(-1) and KF desorption values ranging from 686 to 2468 μg(1-1/n)(cm(3))(1/n)g(-1). The high desorption KF values indicate that norfloxacin is highly immobile in the evaluated soils.
authors.affiliation: Institute of Chemistry, Department of Analytical Chemistry, University of Campinas, PO Box 6154, 13084-971 Campinas, SP, Brazil.
authors.forename: Livia Maniero
authors.initials: LM
authors.lastname: Peruchi
authors.affiliation: Institute of Chemistry, Department of Analytical Chemistry, University of Campinas, PO Box 6154, 13084-971 Campinas, SP, Brazil.
authors.forename: Anne Hélène
authors.initials: AH
authors.lastname: Fostier
authors.affiliation: Institute of Chemistry, Department of Analytical Chemistry, University of Campinas, PO Box 6154, 13084-971 Campinas, SP, Brazil. Electronic address: Susanne.rath@gmail.com.
authors.forename: Susanne
authors.initials: S
authors.lastname: Rath
mesh_terms: D000327:Adsorption; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001938:Brazil; D007700:Kinetics; D008962:Models, Theoretical; D009643:Norfloxacin / Q000737:chemistry*; D012987:Soil / Q000737:chemistry; D012989:Soil Pollutants / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D012987:Soil; D012989:Soil Pollutants; D009643:Norfloxacin
keywords: Antimicrobials; Batch experiments; Brazilian soils; Freundlich sorption isotherms; Matrix effect; Norfloxacin