title: Age-associated changes of brain copper, iron, and zinc in Alzheimer's disease and dementia with Lewy bodies.
abstract: Disease-, age-, and gender-associated changes in brain copper, iron, and zinc were assessed in postmortem neocortical tissue (Brodmann area 7) from patients with moderate Alzheimer's disease (AD) (n = 14), severe AD (n = 28), dementia with Lewy bodies (n = 15), and normal age-matched control subjects (n = 26). Copper was lower (20%; p < 0.001) and iron higher (10-16%; p < 0.001) in severe AD compared with controls. Intriguingly significant Group*Age interactions were observed for both copper and iron, suggesting gradual age-associated decline of these metals in healthy non-cognitively impaired individuals. Zinc was unaffected in any disease pathologies and no age-associated changes were apparent. Age-associated changes in brain elements warrant further investigation.
authors.affiliation: Institute for Global Food Security, Queen's University Belfast, Belfast, Northern Ireland, UK.
authors.forename: Stewart F
authors.initials: SF
authors.lastname: Graham
authors.affiliation: Institute for Global Food Security, Queen's University Belfast, Belfast, Northern Ireland, UK.
authors.forename: Muhammad Bin
authors.initials: MB
authors.lastname: Nasaruddin
authors.affiliation: Institute for Global Food Security, Queen's University Belfast, Belfast, Northern Ireland, UK.
authors.forename: Manus
authors.initials: M
authors.lastname: Carey
authors.affiliation: Division of Biomedical and Life Sciences, Furness Building, Lancaster University, Lancaster, UK.
authors.forename: Christian
authors.initials: C
authors.lastname: Holscher
authors.affiliation: Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, Northern Ireland, UK.
authors.forename: Bernadette
authors.initials: B
authors.lastname: McGuinness
authors.affiliation: Dementia Research Group, Institute of Clinical Neurosciences, School of Clinical Sciences, University of Bristol, Frenchay Hospital, Bristol, UK.
authors.forename: Patrick G
authors.initials: PG
authors.lastname: Kehoe
authors.affiliation: Dementia Research Group, Institute of Clinical Neurosciences, School of Clinical Sciences, University of Bristol, Frenchay Hospital, Bristol, UK.
authors.forename: Seth
authors.initials: S
authors.lastname: Love
authors.affiliation: Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, Northern Ireland, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Passmore
authors.affiliation: Institute for Global Food Security, Queen's University Belfast, Belfast, Northern Ireland, UK.
authors.forename: Christopher T
authors.initials: CT
authors.lastname: Elliott
authors.affiliation: Institute for Global Food Security, Queen's University Belfast, Belfast, Northern Ireland, UK.
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Meharg
authors.affiliation: Institute for Global Food Security, Queen's University Belfast, Belfast, Northern Ireland, UK.
authors.forename: Brian D
authors.initials: BD
authors.lastname: Green
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism; D000544:Alzheimer Disease / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D003300:Copper / Q000378:metabolism*; D005260:Female; D006801:Humans; D007501:Iron / Q000378:metabolism*; D020961:Lewy Body Disease / Q000378:metabolism*; D008297:Male; D012720:Severity of Illness Index; D015032:Zinc / Q000378:metabolism*
chemical_list: D003300:Copper; D007501:Iron; D015032:Zinc
keywords: Alzheimer's disease; Lewy body; brain; copper; dementia; iron; trace elements; zinc