title: Role of surgery in multi-modality treatment for carcinomatous pleuritis in patients with non-small cell lung cancer.
abstract: OBJECTIVE
  To evaluate the role of surgery in the treatment of the patients with non-small cell lung cancer with pleural dissemination.
  
  
  METHODS
  The clinical records of 25 patients (mean age 69 years) diagnosed with carcinomatous pleuritis during a thoracotomy by pathological examination and followed by surgery between 1994 and 2012 were reviewed. The treatment modality, including surgery, the clinicopathologic characteristics and 5-year survival were analyzed.
  
  
  RESULTS
  There were 16 adenocarcinomas, 6 squamous cell carcinomas and 3 large cell carcinomas. Surgery included resection of the main tumor by partial resection in 10 cases, segmentectomy in 2 cases, lobar resection in 12 cases and bilobectomy in 1 case. Intrathoracic irrigation was performed in 20 cases. The pathological N status was N0/N1/N2/Nx: 10/6/7/2. Fifteen patients received adjuvant therapy. The overall 5-year survival rate was 22.2 %. The 5-year survival rates of the N0, N1 and N2 groups were 36.0, 16.7 and 14.3 %, respectively (p = 0.0068). Nine patients lived more than 3 years including 5 in N0, 3 in N1 and 1 in N2.
  
  
  CONCLUSIONS
  Surgery should not be excluded from the multi-modality treatment of patients with carcinomatous pleuritis because there are some patients who could benefit from surgery especially if they are in N0 status.
authors.affiliation: Department of General Thoracic, Breast and Endocrine Surgery, Faculty of Medicine, Kagawa University, 1750-1 Miki-Cho, Kita-Gun, Kagawa, 761-0793, Japan, tetsu-g@med.kagawa-u.ac.jp.
authors.forename: Tetsuhiko
authors.initials: T
authors.lastname: Go
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Misaki
authors.forename: Natsumi
authors.initials: N
authors.lastname: Matsuura
authors.forename: Sung Soo
authors.initials: SS
authors.lastname: Chang
authors.forename: Shintarou
authors.initials: S
authors.lastname: Tarumi
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Yokomise
mesh_terms: D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications* / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010994:Pleura / Q000601:surgery; D016066:Pleural Effusion, Malignant / Q000209:etiology* / Q000601:surgery*; D010998:Pleurisy / Q000209:etiology* / Q000601:surgery*; D011013:Pneumonectomy; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate