title: Utility of the Spanish version of the FTLD-modified CDR in the diagnosis and staging in frontotemporal lobar degeneration.
abstract: BACKGROUND
  The Clinical Dementia Rating Scale (CDR) is a tool designed to quantify the severity of dementia symptoms and is also useful to assess disease progression, in Alzheimer's disease (AD). A new version of the scale was developed by adding two extra domains that focused on the core aspects of frontotemporal dementia symptomatology, Language and Behavior/Comportment/Personality.
  
  
  OBJECTIVE
  In this study, we adapted and validated the modified CDR scale in our setting and language (Rioplatense-Spanish).
  
  
  METHODS
  46 patients with probable AD, 27 behavioral variant of Frontotemporal Dementia (bvFTD), 18 Primary Progressive Aphasia (PPA) and 40 healthy participants were included. The adapted version of the scale was administered by a blind rater who interviewed patients together with patient's caregiver.
  
  
  RESULTS
  Using ROC curves, the domain language and behavior were superior to the memory domain in accuracy for detecting PPA and bvFTD, respectively, but both of them had equivalent diagnostic accuracies for probable AD. Logistic regression analyses showed that either the LANG or BEHAV domains significantly improved the discrimination between probable AD, bvFTD and PPA.
  
  
  CONCLUSIONS
  The Spanish version of the modified CDR adds value for the characterization of the non-amnestic symptoms in patients with neurodegenerative dementias.
authors.affiliation: Department of Cognitive Neurology, Instituto de Investigaciones Neurológicas Raúl Carrea (FLENI), Buenos Aires, Argentina. Electronic address: grusso@fleni.org.ar.
authors.forename: Griselda
authors.initials: G
authors.lastname: Russo
authors.affiliation: Department of Cognitive Neurology, Instituto de Investigaciones Neurológicas Raúl Carrea (FLENI), Buenos Aires, Argentina.
authors.forename: María Julieta
authors.initials: MJ
authors.lastname: Russo
authors.affiliation: Department of Cognitive Neurology, Instituto de Investigaciones Neurológicas Raúl Carrea (FLENI), Buenos Aires, Argentina.
authors.forename: Daniela
authors.initials: D
authors.lastname: Buyatti
authors.affiliation: Department of Cognitive Neurology, Instituto de Investigaciones Neurológicas Raúl Carrea (FLENI), Buenos Aires, Argentina.
authors.forename: Patricio
authors.initials: P
authors.lastname: Chrem
authors.affiliation: Department of Cognitive Neurology, Instituto de Investigaciones Neurológicas Raúl Carrea (FLENI), Buenos Aires, Argentina.
authors.forename: Pablo
authors.initials: P
authors.lastname: Bagnati
authors.affiliation: Department of Cognitive Neurology, Instituto de Investigaciones Neurológicas Raúl Carrea (FLENI), Buenos Aires, Argentina.
authors.forename: Marcos
authors.initials: M
authors.lastname: Fernández Suarez
authors.affiliation: Department of Cognitive Neurology, Instituto de Investigaciones Neurológicas Raúl Carrea (FLENI), Buenos Aires, Argentina.
authors.forename: Jorge
authors.initials: J
authors.lastname: Campos
authors.affiliation: Department of Cognitive Neurology, Instituto de Investigaciones Neurológicas Raúl Carrea (FLENI), Buenos Aires, Argentina.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Cohen
authors.affiliation: Department of Cognitive Neurology, Instituto de Investigaciones Neurológicas Raúl Carrea (FLENI), Buenos Aires, Argentina.
authors.forename: Alejandra
authors.initials: A
authors.lastname: Amengual
authors.affiliation: Department of Cognitive Neurology, Instituto de Investigaciones Neurológicas Raúl Carrea (FLENI), Buenos Aires, Argentina.
authors.forename: Ricardo F
authors.initials: RF
authors.lastname: Allegri
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester MN, USA.
authors.forename: David S
authors.initials: DS
authors.lastname: Knopman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D057174:Frontotemporal Lobar Degeneration / Q000175:diagnosis* / Q000503:physiopathology*; D006801:Humans; D007802:Language; D008297:Male; D008568:Memory; D008875:Middle Aged; D009483:Neuropsychological Tests; D010551:Personality; D012372:ROC Curve; D012720:Severity of Illness Index; D014175:Translating
keywords: Alzheimer disease; Behavior; Frontotemporal dementia; Neuropsychology; Primary progressive aphasia; Rating scales