title: Identification of arylsulfonamides as ExoU inhibitors.
abstract: ExoU is a potent virulence factor of Pseudomonas aeruginosa and is considered a potential therapeutic target. In order to discover novel ExoU inhibitors, we screened an in-house chemical library utilizing a yeast-based screening system. Some sulfonamides displayed significant activity without nonspecific cytotoxicity. We describe a series of sulfonamides as novel ExoU inhibitors, along with a brief structure-activity relationship.
authors.affiliation: College of Pharmacy, Chung-Ang University, Seoul 156-756, Republic of Korea.
authors.forename: Doran
authors.initials: D
authors.lastname: Kim
authors.affiliation: College of Pharmacy, Chung-Ang University, Seoul 156-756, Republic of Korea.
authors.forename: Jihae
authors.initials: J
authors.lastname: Baek
authors.affiliation: College of Pharmacy, Chung-Ang University, Seoul 156-756, Republic of Korea.
authors.forename: Jiho
authors.initials: J
authors.lastname: Song
authors.affiliation: College of Pharmacy, Chung-Ang University, Seoul 156-756, Republic of Korea.
authors.forename: Hyeyoung
authors.initials: H
authors.lastname: Byeon
authors.affiliation: College of Pharmacy, Chung-Ang University, Seoul 156-756, Republic of Korea. Electronic address: hymin@cau.ac.kr.
authors.forename: Hyeyoung
authors.initials: H
authors.lastname: Min
authors.affiliation: College of Pharmacy, Chung-Ang University, Seoul 156-756, Republic of Korea. Electronic address: khmin@cau.ac.kr.
authors.forename: Kyung Hoon
authors.initials: KH
authors.lastname: Min
mesh_terms: D001426:Bacterial Proteins / Q000037:antagonists & inhibitors*; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D057809:HEK293 Cells; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D001426:Bacterial Proteins; D013449:Sulfonamides; C111749:pseudomonas exoprotein A protein, Pseudomonas aeruginosa
keywords: ExoU; Pseudomonas aeruginosa; Small molecule; Sulfonamides