title: Antimalarial efficacy of dynamic compound of plumbagin chemical constituent from Plumbago zeylanica Linn (Plumbaginaceae) against the malarial vector Anopheles stephensi Liston (Diptera: Culicidae).
abstract: In the present investigation, the effective root compound of plumbagin of Plumbago zeylanica (Plumbaginaceae) was evaluated for chemical constituent and antimalarial effect against the fourth instar larvae of Anopheles stephensi Liston (Diptera). In the chromatographic analyses of root compound with Rf value of 0.788 and NMR analyses also revealed that the effective compound contain naphthoquinone plumbagin were identified as the major chemical constituent. Larval mortality was observed after 3 h of exposure period. The plumbagin compound showed remarkable larvicidal activity against A. stephensi (LC50 32.65 and LC9072.27 ppm). Histopathological effects of compound was observed in the treated larvae. Based on the results, the plumbagin compound of P. zeylanica can be considered as a new source of natural larvicide for the control of malarial vector.
authors.affiliation: Division of Biopesticides and Environmental Toxicology, Sri Paramakalyani Centre for Excellence in Environmental Sciences, Manonmaniam Sundaranar University, Alwarkurichi - 627 412, Tirunelveli, Tamil Nadu, India.
authors.forename: Venkatraman
authors.initials: V
authors.lastname: Pradeepa
authors.forename: Subbiah
authors.initials: S
authors.lastname: Sathish-Narayanan
authors.forename: Suyambulingam Arunachalam
authors.initials: SA
authors.lastname: Kirubakaran
authors.forename: Sengottayan
authors.initials: S
authors.lastname: Senthil-Nathan
mesh_terms: D000818:Animals; D000852:Anopheles; D007306:Insecticides; D007814:Larva; D009285:Naphthoquinones / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry; D029606:Plumbaginaceae / Q000737:chemistry*
chemical_list: D007306:Insecticides; D009285:Naphthoquinones; D010936:Plant Extracts; C014758:plumbagin