title: Other PET tracers for neuroendocrine tumors.
abstract: In this article the applicability of (124)I-MIBG and (11)C-5-HTP PET for the detection of abdominal gastro-enteropancreatic neuroendocrine tumors is discussed. (124)I-MIBG is a positron-emitting variant of (123)I-MIBG and therefore suited for PET imaging. Due to the better intrinsic characteristics of PET, (124)I-MIBG PET has a higher spatial resolution than (123)I-MIBG and may therefore lead to better lesion detection in patients with neuroblastoma and pheochromocytoma. Research is ongoing to develop (18)F-labeled analogues and to assess its place in staging patients with gastro-enteropancreatic neuroendocrine tumors when compared with (18)F-FDOPA and (68)Ga-somatostatin PET analogues.
authors.affiliation: Department of Radiology and Nuclear Medicine, Martini Hospital Groningen, Van Swietenplein 1, Groningen 9728 NT, The Netherlands. Electronic address: k.koopmans@mzh.nl.
authors.forename: Klaas Pieter
authors.initials: KP
authors.lastname: Koopmans
authors.affiliation: Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
authors.forename: Andor W J M
authors.initials: AW
authors.lastname: Glaudemans
mesh_terms: D019797:3-Iodobenzylguanidine; D006916:5-Hydroxytryptophan; D002250:Carbon Radioisotopes; D006801:Humans; D007414:Intestinal Neoplasms / Q000000981:diagnostic imaging; D018358:Neuroendocrine Tumors / Q000000981:diagnostic imaging*; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging
chemical_list: D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine; D006916:5-Hydroxytryptophan
keywords: (11)C-5-HTP PET; (124)I-MIBG; Neuroendocrine tumor; Pancreatic islet cell tumor