title: Electroacupuncture at ST36-ST37 and at ear ameliorates hippocampal mossy fiber sprouting in kainic acid-induced epileptic seizure rats.
abstract: Our previous study showed that mossy fiber sprouting can occur in the hippocampus region in rats 6 wk after kainic acid-induced epileptic seizure, and this mossy fiber sprouting can facilitate epileptogenesis. Transcutaneous auricular vagal nerve stimulation (VNS), which is similar to cervical VNS, can reduce the occurrence of epileptic seizure in intractable epilepsy patients. Greater parasympathetic nerve activity can be caused by 2 Hz electroacupuncture (EA). Therefore, we investigated the effect of 2 Hz EA at ST-36-ST37 and at the ear on mossy fiber sprouting in kainic-treated Sprague-Dawley rats. The results indicated that applying 2 Hz EA at ST36-ST37 and at the ear for 3 d per week over 6 consecutive weeks can ameliorate mossy fiber sprouting in the hippocampus region of rats. These results indicated that applying 2 Hz EA at ST36-ST37 and at the ear might be beneficial for the treatment and prevention of epilepsy in humans.
authors.affiliation: Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, 91 Hsueh-Shih Road, Taichung 40402, Taiwan ; Department of Neurology, China Medical University Hospital, Taichung 40402, Taiwan.
authors.forename: Chung-Hsiang
authors.identifier: 0000-0002-1742-8834
authors.initials: CH
authors.lastname: Liu
authors.affiliation: Research Center for Chinese Medicine & Acupuncture, China Medical University, Taichung 40402, Taiwan ; Graduate Institute of Acupuncture Science, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan.
authors.forename: Yi-Wen
authors.initials: YW
authors.lastname: Lin
authors.affiliation: Department of Chinese Medicine, China Medical University Hospital, Taichung 40402, Taiwan ; Graduate Institute of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan.
authors.forename: Hsin-Cheng
authors.identifier: 0000-0002-9150-0339
authors.initials: HC
authors.lastname: Hsu
authors.affiliation: Research Center for Chinese Medicine & Acupuncture, China Medical University, Taichung 40402, Taiwan ; Graduate Institute of Acupuncture Science, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan.
authors.forename: Hsu-Jan
authors.initials: HJ
authors.lastname: Liu
authors.affiliation: Graduate Institute of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan.
authors.forename: Wan-Jung
authors.initials: WJ
authors.lastname: Lin
authors.affiliation: Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, 91 Hsueh-Shih Road, Taichung 40402, Taiwan ; Research Center for Chinese Medicine & Acupuncture, China Medical University, Taichung 40402, Taiwan ; Department of Chinese Medicine, China Medical University Hospital, Taichung 40402, Taiwan.
authors.forename: Ching-Liang
authors.identifier: 0000-0002-8187-4716
authors.initials: CL
authors.lastname: Hsieh
mesh_terms: D020831:Acupuncture, Ear; D000818:Animals; D015671:Electroacupuncture; D004827:Epilepsy / Q000139:chemically induced / Q000473:pathology / Q000628:therapy*; D004833:Epilepsy, Temporal Lobe / Q000139:chemically induced / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007608:Kainic Acid / Q000633:toxicity; D019599:Mossy Fibers, Hippocampal / Q000473:pathology; D009474:Neurons / Q000187:drug effects / Q000473:pathology; D051381:Rats
chemical_list: D007608:Kainic Acid