title: Mechanical ventilation and management of an adult horse with presumptive botulism.
abstract: OBJECTIVE
  To describe the clinical course, management, and outcome of a horse with a presumptive diagnosis of botulism treated with long-term mechanical ventilation.
  
  
  METHODS
  A 6-year-old Quarter Horse gelding with a history of esophageal obstruction was evaluated for progressive tetraparesis. Generalized and progressive skeletal muscle weakness characterized by recumbency, decreased tongue, tail, eyelid, and anal tone, and respiratory failure was observed. Anticholinergic signs including decreased salivation, xerophthalmia, and ileus were also noted. A presumptive diagnosis of botulism was made, although mouse inoculation and spore identification testing were negative. Pentavalent botulism antitoxin was administered on Day 3. The horse was maintained on a water mattress and was managed with mechanical ventilation for 2 weeks. Complications encountered included necrotic rhinitis, intertrigo, decubital ulceration, jugular and cephalic vein thrombophlebitis, corneal ulceration, and transient ventricular tachycardia. The horse showed marked improvement in skeletal muscle strength and parasympathetic nervous system function, allowing it to be successfully weaned from the ventilator but suffered large colon volvulus on Day 21 and was euthanized.
  
  
  CONCLUSIONS
  To the authors' knowledge, this is the first report of successful weaning from long-term mechanical ventilation and management of recumbency using a water mattress in an adult horse with presumptive botulism.
authors.affiliation: Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, IN, 47907.
authors.forename: Sandra D
authors.initials: SD
authors.lastname: Taylor
authors.forename: Balazs
authors.initials: B
authors.lastname: Toth
authors.forename: Wendy M
authors.initials: WM
authors.lastname: Townsend
authors.forename: Robin Timothy
authors.initials: RT
authors.lastname: Bentley
mesh_terms: D000818:Animals; D001904:Botulinum Antitoxin / Q000627:therapeutic use*; D001906:Botulism / Q000628:therapy / Q000662:veterinary*; D006734:Horse Diseases / Q000628:therapy*; D006736:Horses; D008297:Male; D012121:Respiration, Artificial / Q000662:veterinary*; D013997:Time Factors
chemical_list: D001904:Botulinum Antitoxin
keywords: complications; equine; respiratory failure; ventilatory support