title: New phenolics from the root of Scutellaria prostrata JACQ. ex BENTH.
abstract: Scutellaria prostrata (Lamiaceae), a perennial herb growing as a lonely species in Kashmir, Himalayas, was subjected to repetitive column and flash chromatographic isolation for its chemical documentation-cum-bioevaluation. The methanolic extract of S.prostrata afforded the isolation of ten compounds (1-10), including two new compounds - scutellapbiflavanone (1) and scutellaprostin M (2). The known compounds were found to be scutellarin (3), hispidulin-7-O-β-D-glucopyranoside (4), baicalin (5), wogonoside (6), scutellaprostin C (7), acetoside (8), martynoside (9) and scutellaric acid-3-O-β-D-glucopyranoside (10). Isolation of biflavonoids, phenolics and phenylethanoid compounds from S. prostrata seals a deal of chemotaxonomic importance of this particular species. The characterisation of the compounds was achieved by (1)H, (13)C, (1)H-(1)H DFQ COSY, HMBC, HSQC, HMQC and ROESY NMR experiments. All the compounds were tested for antioxidant, antimicrobial and cytotoxic activities.
authors.affiliation: a Natural Products Chemistry Division, CSIR-Indian Institute of Integrative Medicine , Srinagar , Kashmir , 190005 , India.
authors.forename: Gulzar
authors.initials: G
authors.lastname: Bhat
authors.forename: Bashir A
authors.initials: BA
authors.lastname: Ganai
authors.forename: Abdul S
authors.initials: AS
authors.lastname: Shawl
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry; D000975:Antioxidants / Q000737:chemistry; D047310:Apigenin / Q000737:chemistry / Q000302:isolation & purification; D044946:Biflavonoids / Q000737:chemistry / Q000302:isolation & purification*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification*; D005965:Glucuronates / Q000737:chemistry / Q000302:isolation & purification; D018922:HL-60 Cells; D006801:Humans; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*; D031363:Scutellaria / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D000975:Antioxidants; D044946:Biflavonoids; D005419:Flavonoids; D005965:Glucuronates; D010636:Phenols; D010936:Plant Extracts; C484876:scutellarin; D047310:Apigenin
keywords: Scutellariaprostrata; antimicrobial; antioxidant; biflavonoids; cytotoxic activity; phenolics; phenylethanoids