title: Role of skin immune cells on the host susceptibility to mosquito-borne viruses.
abstract: Due to climate change and the propagation of competent arthropods worldwide, arboviruses have become pathogens of major medical importance. Early transmission to vertebrates is initiated by skin puncture and deposition of virus together with arthropod saliva in the epidermis and dermis. Saliva components have the capacity to modulate skin cell responses by enhancing and/or counteracting initial replication and establishment of systemic viral infection. Here, we review the nature of the cells targeted by arboviruses at the skin level and discuss the type of cellular responses elicited by these pathogens in light of the immunomodulatory properties of arthropod vector-derived salivary factors injected at the inoculation site. Understanding cutaneous arbovirus-host interactions may provide new clues for the design of future therapeutics.
authors.affiliation: CPBS, Centre d׳études d׳agents Pathogènes et Biotechnologies pour la Santé, UMR5236 CNRS, Université Montpellier 1,2, Montpellier, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Briant
authors.affiliation: Unité Interactions Moléculaires Flavivirus-Hôtes, Institut Pasteur, Paris, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Desprès
authors.affiliation: Unité Interactions Moléculaires Flavivirus-Hôtes, Institut Pasteur, Paris, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Choumet
authors.affiliation: MIVEGEC (IRD 224 CNRS 5290-UM1-UM2) Maladies infectieuses et vecteurs: écologie, génétique, évolution et contrôle, Centre IRD de Montpellier, Montpellier, France. Electronic address: dorothee.misse@ird.fr.
authors.forename: Dorothée
authors.initials: D
authors.lastname: Missé
mesh_terms: D000330:Aedes / Q000821:virology*; D000818:Animals; D001102:Arbovirus Infections / Q000276:immunology* / Q000821:virology; D001103:Arboviruses / Q000502:physiology*; D006801:Humans; D007303:Insect Vectors / Q000821:virology*; D012871:Skin Diseases / Q000276:immunology* / Q000821:virology
keywords: Arboviruses; Chikungunya; Dengue; Innate immunity; Mosquito saliva; Rift Valley Fever; Skin; West Nile virus