title: Nonequivalent response to bromodomain-targeting BET inhibitors in oligodendrocyte cell fate decision.
abstract: The tandem bromodomains (BD1 and BD2) of the BET family proteins BRD2, BRD3, BRD4, and BRDT are structurally conserved but not functionally equivalent. In this issue of Chemistry & Biology, Gacias and colleagues report that a BD1-specific chemical inhibitor, Olinone, enhances oligodendrocyte differentiation, contrasting the reverse process triggered by broad BD1/BD2-targeting inhibitors, highlighting distinct roles of BD1 and BD2 in cell fate decision.
authors.affiliation: Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA; Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA; Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. Electronic address: cheng-ming.chiang@utsouthwestern.edu.
authors.forename: Cheng-Ming
authors.initials: CM
authors.lastname: Chiang
mesh_terms: D000818:Animals; D006801:Humans; D009836:Oligodendroglia / Q000166:cytology* / Q000187:drug effects*; D054852:Small Molecule Libraries / Q000494:pharmacology*; D014157:Transcription Factors / Q000737:chemistry* / Q000378:metabolism*; D014158:Transcription, Genetic / Q000187:drug effects*
chemical_list: D054852:Small Molecule Libraries; D014157:Transcription Factors