title: Androgen actions in the ovary: balance is key.
abstract: For many decades, elevated androgens in women have been associated with poor reproductive health. However, recent studies have shown that androgens play a crucial role in women's fertility. The following review provides an overall perspective about how androgens and androgen receptor-mediated actions regulate normal follicular development, as well as discuss emerging concepts, latest perceptions, and controversies regarding androgen actions and signaling in the ovary.
authors.affiliation: Division of Endocrinology and MetabolismDepartment of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, PO Box 693, Rochester, New York 14642, USACenter for Human ReproductionNew York, New York 10021, USA.
authors.forename: Hen
authors.initials: H
authors.lastname: Prizant
authors.affiliation: Division of Endocrinology and MetabolismDepartment of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, PO Box 693, Rochester, New York 14642, USACenter for Human ReproductionNew York, New York 10021, USA.
authors.forename: Norbert
authors.initials: N
authors.lastname: Gleicher
authors.affiliation: Division of Endocrinology and MetabolismDepartment of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, PO Box 693, Rochester, New York 14642, USACenter for Human ReproductionNew York, New York 10021, USADivision of Endocrinology and MetabolismDepartment of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, PO Box 693, Rochester, New York 14642, USACenter for Human ReproductionNew York, New York 10021, USA aritro_sen@urmc.rochester.edu.
authors.forename: Aritro
authors.initials: A
authors.lastname: Sen
mesh_terms: D066258:Amphiregulin; D000728:Androgens / Q000502:physiology*; D000818:Animals; D051546:Cyclooxygenase 2 / Q000235:genetics / Q000502:physiology; D066255:EGF Family of Proteins; D005260:Female; D005298:Fertility / Q000235:genetics / Q000502:physiology; D015870:Gene Expression; D006023:Glycoproteins / Q000235:genetics / Q000502:physiology; D055429:Growth Differentiation Factor 9 / Q000502:physiology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D035683:MicroRNAs / Q000235:genetics; D023421:Models, Animal; D006080:Ovarian Follicle / Q000502:physiology; D010053:Ovary / Q000502:physiology*; D011944:Receptors, Androgen / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D011962:Receptors, FSH / Q000502:physiology; D015398:Signal Transduction; D013002:Somatomedins / Q000502:physiology; D019089:Stem Cell Factor / Q000235:genetics
chemical_list: C587848:AREG protein, human; D066258:Amphiregulin; D000728:Androgens; C587849:Areg protein, mouse; D066255:EGF Family of Proteins; D006023:Glycoproteins; D055429:Growth Differentiation Factor 9; D036341:Intercellular Signaling Peptides and Proteins; D035683:MicroRNAs; D011944:Receptors, Androgen; D011962:Receptors, FSH; D013002:Somatomedins; D019089:Stem Cell Factor; D051546:Cyclooxygenase 2
keywords: androgen; androgen receptor; female reproduction; ovary