title: [Hemorrhagic dengue and vertical transmission to the newborn: a case report and literature review].
abstract: OBJECTIVE
  To describe the case of a patient with term pregnancy and infection with hemorrhagic dengue and vertical transmission to the newborn.
  
  
  METHODS
  Thirty-two year old patient with pregnancy at 38 weeks was admitted with fever 2 days earlier (38 degrees C). During her stay she continued with fever of 39 degrees C and platelets of 85,000/mm3. Serology for dengue NS1 antigen was reported positive. Labor was induced getting a new-born, male, 3,220 g, who breathed and cried at birth. During the postpartum period continued with fever, malaise, retro-ocular pain, generalized rash in upper and lower limbs, bleeding gums and petechial on the soft palate and thrombocytopenia of 5,000/mm3, later. At 8 days of stay, platelet concentration increased to 42,000/mm3 without requiring platelet concentrates and she was discharged after ten days in hospital with platelets of 94,000/mm3. The 4th day of extra-uterine live (EUL), neonate shows generalized rash over the trunk; The 5th day starts with 38 degrees C fever and thrombocytopenia (78,000/mm3). Dengue serological tests reported positive for Ag NS1 and negative for Abs IgM and IgG. Neonate was admitted to NICU, he continued with a decrease in platelet of 14,000/mm3- and ecchymotic areas by pressure and veno-punction sites. Four platelet concentrates were transfused. At 10th day of EUL platelet count was reported with 387,000/mm3.
  
  
  CONCLUSIONS
  In an endemic area, such as Sinaloa state, in a pregnant woman with fever and thrombocytopenia, we should be alert to possibility of a DV infection and its complications. Although rare, such as this case, infection can be transmitted to fetus (vertical transmission) and produce a primary congenital dengue, even in its severe hemorrhagic types.
authors.forename: Fred
authors.initials: F
authors.lastname: Morgan-Ortiz
authors.forename: Silvia Mirelle
authors.initials: SM
authors.lastname: Rodríguez-Lugo
authors.forename: María del Socorro
authors.initials: Mdel S
authors.lastname: León-Gil
authors.forename: Marisela
authors.initials: M
authors.lastname: Gaxiola-Villa
authors.forename: Nora Selene
authors.initials: NS
authors.lastname: Martínez-Félix
authors.forename: Leticia
authors.initials: L
authors.lastname: Lara-Avila
mesh_terms: D000328:Adult; D005260:Female; D005334:Fever / Q000821:virology; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D007363:Intensive Care Units, Neonatal; D008297:Male; D010976:Platelet Count; D049590:Postpartum Period; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000821:virology*; D019595:Severe Dengue / Q000175:diagnosis / Q000503:physiopathology / Q000635:transmission*; D013921:Thrombocytopenia / Q000821:virology*