title: Endometrial carcinoma in women 40 year old or younger: a case report and literature review.
abstract: Endometrial cancer is the most frequent gynecologic cancer. Although it mainly occurs in menopausal women, it can hit younger patients as well. Only few cases of affected women under the age of 30 are reported. A case of a 23-year-old patient with endometrioid carcinoma grade II-III is presented. Hysterectomy is considered the standard treatment and it could represent a problem for those young women who desire to preserve fertility. A conservative management can be offered to these patients when the tumor is well differentiated and advanced stage is excluded. Several studies are available in literature about fertility sparing approach. Progestin treatment, combined or not with hysteroscopic ablation seem to be the most validated conservative management. Anyhow this treatment is not free risk, because it is not always effective and disease progression during or after treatment is possible. Then a strict evaluation and selection of patients before starting treatment is mandatory.
authors.affiliation: Department of Surgical and Biomedical Sciences, University of Perugia, Perugia, Italy. sandro.gerli@unipg.it.
authors.forename: S
authors.initials: S
authors.lastname: Gerli
authors.forename: F
authors.initials: F
authors.lastname: Spanò
authors.forename: G C
authors.initials: GC
authors.lastname: Di Renzo
mesh_terms: D000328:Adult; D000367:Age Factors; D018269:Carcinoma, Endometrioid / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D005260:Female; D059247:Fertility Preservation; D006801:Humans; D007044:Hysterectomy; D011372:Progestins / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D011372:Progestins