title: A polymorphism in AGT and AGTR1 gene is associated with lead-related high blood pressure.
abstract: We investigated the association of polymorphisms in two renin-angiotensin system-related genes, expressed as angiotensinogen (AGT) and angiotensin II type 1 receptor (AGTR1), with blood lead levels and lead-related blood pressure in lead-exposed male workers in Korea. A cross-sectional study involving 808 lead-exposed male workers in Korea was conducted using a restriction fragment length polymorphism-based strategy to differentiate the various genotypes of polymorphisms in the AGT and AGTR1 genes. The association of clinical characteristics with genotypes as modifiers was estimated after adjustment for age, smoking status, drinking status, body mass index and job duration of each subject. Genotype and allele frequencies of the M235T polymorphism in AGT were associated with lead-related high blood pressure status. Moreover, blood lead levels were associated with allele frequencies of the AGT M235T polymorphism. These results suggested that the M/M genotype and M allele of AGT are risk factors for lead-related high blood pressure.
authors.affiliation: Department of Clinical Pharmacology, College of Medicine, Soonchunhyang University, Republic of Korea.
authors.forename: Hyung-Ki
authors.initials: HK
authors.lastname: Kim
authors.affiliation: Department of Clinical Pharmacology, College of Medicine, Soonchunhyang University, Republic of Korea.
authors.forename: Hwayoung
authors.initials: H
authors.lastname: Lee
authors.affiliation: Department of Clinical Pharmacology, College of Medicine, Soonchunhyang University, Republic of Korea.
authors.forename: Jun-Tack
authors.initials: JT
authors.lastname: Kwon
authors.affiliation: Department of Clinical Pharmacology, College of Medicine, Soonchunhyang University, Republic of Korea Soonchunhyang Medical Research Institute, College of Medicine, Soonchunhyang University, Republic of Korea Kowhang Medical Research Institute, School of Medicine, Kyung Hee University, Republic of Korea hak3962@sch.ac.kr.
authors.forename: Hak-Jae
authors.initials: HJ
authors.lastname: Kim
mesh_terms: D000328:Adult; D000808:Angiotensinogen / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000235:genetics*; D007854:Lead / Q000097:blood*; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics*
chemical_list: D044140:Receptor, Angiotensin, Type 1; D000808:Angiotensinogen; D007854:Lead
keywords: Angiotensin II type 1 receptor; angiotensinogen; hypertension; lead; polymorphism