title: Protein tyrosine phosphatase receptor R and Z1 expression as independent prognostic indicators in oral squamous cell carcinoma.
abstract: BACKGROUND
  The actions of tyrosine phosphorylation and dephosphorylation are controlled by tyrosine kinases and phosphatases. Although substantial previous data have revealed the role of several protein tyrosine phosphatases (PTPs) in various cancers, the function of protein tyrosine phosphatase receptor R (PTPRR) and protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (PTPRZ1) proteins in oral cavity squamous cell carcinoma (SCC) has not been studied to date.
  
  
  METHODS
  The PTPRR and PTPRZ1 immunoreactivity in 67 formalin-fixed and paraffin-embedded oral cancer tissues at different stages were analyzed with the technique of immunohistochemistry (IHC). The presence of PTPRR in cancerous tissue was confirmed by Western blotting.
  
  
  RESULTS
  The occurrence of PTPRR and PTPRZ1 proteins in the cancer specimens was more frequent in lower grade tumors. In addition, the association between the immunoreactivity of both examined proteins and improved patients survival was detected. Moreover, the PTPRR expression was found to be related to the absence of synchronous lymph node involvement.
  
  
  CONCLUSIONS
  The above results indicate that the PTPRR and PTPRZ1 protein expression should be monitored in oral cancer for patients' prognostic stratification.
authors.affiliation: Department of Pathology, Wrocław Medical University, Wrocław, Poland.
authors.forename: Kamila
authors.initials: K
authors.lastname: Duś-Szachniewicz
authors.affiliation: Department of Pathology, Wrocław Medical University, Wrocław, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Woźniak
authors.affiliation: Department of Maxillo-Facial Surgery, Wrocław Medical University, Wrocław, Poland.
authors.forename: Kamil
authors.initials: K
authors.lastname: Nelke
authors.affiliation: Department of Pathology, Wrocław Medical University, Wrocław, Poland.
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Gamian
authors.affiliation: Department of Maxillo-Facial Surgery, Wrocław Medical University, Wrocław, Poland.
authors.forename: Hanna
authors.initials: H
authors.lastname: Gerber
authors.affiliation: Department of Pathology, Wrocław Medical University, Wrocław, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Ziółkowski
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000201:enzymology* / Q000235:genetics / Q000401:mortality; D006785:Hospitals, University; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000175:diagnosis* / Q000201:enzymology* / Q000235:genetics / Q000401:mortality; D011237:Predictive Value of Tests; D011379:Prognosis; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D054633:Receptor-Like Protein Tyrosine Phosphatases, Class 5 / Q000378:metabolism*; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; D020794:Receptor Protein-Tyrosine Kinases; C516895:PTPRZ1 protein, human; D017027:Protein Tyrosine Phosphatases; D054633:Receptor-Like Protein Tyrosine Phosphatases, Class 5
keywords: Western blot analysis; immunohistochemistry; oral cavity squamous cell carcinoma (SSC); protein tyrosine phosphatase receptor R and Z1; protein tyrosine phosphatases (PTPs)