title: Acute effect of primary percutaneous coronary intervention on left ventricular dyssynchrony in ST-segment elevation myocardial infarction.
abstract: OBJECTIVE
  The aim of this study was to prospectively evaluate the effect of percutaneous coronary intervention in the acute period on left ventricular dyssynchrony in ST-segment elevation myocardial infarction patients by using Tissue Synchronization Imaging.
  
  
  METHODS
  Forty-four ST-segment elevation myocardial infarction (MI) patients (29 male, 15 female), who were admitted within the first 12 hours of chest pain symptoms, were enrolled in the study. According to the localization of MI, the patients were divided into groups as anterior MI (n=26) and inferior MI (n=18). All echocardiography measurements were taken just before percutaneous coronary intervention (PCI) and following PCI at a mean of 3-6 days. They were assessed according to the time to reach the peak systolic velocity, which was calculated by the tissue synchronization imaging method from four pairs of non-apical alternate segments. The difference between the duration to reach the peak systolic velocity in alternate segments was regarded as left ventricle dyssynchrony and the results were compared.
  
  
  RESULTS
  In the anterior MI group, basal anterior (p<0.01), mid-anterior segment (p<0.01) and basal septal segment (p<0.01); in the inferior MI group, the basal septal segment (p=0.02), mid-septal segment (p=0.02), and basal and mid-inferior segment (p<0.01) values were significantly lower in the post-PCI measurements when compared to the measurements taken prior to PCI. In both groups, the intraventricular dyssynchrony indices of the basal anterior-basal inferior (p<0.01), mid-anterior-mid-inferior (p<0.01) segments were found to be significantly lower in the post-PCI period when compared to the pre-PCI period.
  
  
  CONCLUSIONS
  It was found that percutaneous coronary intervention in patients with ST-elevation significantly decreases the degree of LV dyssynchrony in the acute period.
authors.affiliation: Department of Cardiology, Faculty of Medicine, Atatürk University; Erzurum-Turkey. doktorsinaninci@gmail.com.
authors.forename: Sinan
authors.initials: S
authors.lastname: İnci
authors.forename: Şule
authors.initials: Ş
authors.lastname: Karakelleoğlu
authors.forename: M Hakan
authors.initials: MH
authors.lastname: Taş
authors.forename: Şakir
authors.initials: Ş
authors.lastname: Arslan
authors.forename: Fuat
authors.initials: F
authors.lastname: Gündoğdu
authors.forename: Eftal Murat
authors.initials: EM
authors.lastname: Bakırcı
authors.forename: Hüsnü
authors.initials: H
authors.lastname: Değirmenci
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Şenocak
mesh_terms: D001145:Arrhythmias, Cardiac / Q000503:physiopathology*; D057791:Cardiac Imaging Techniques; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000503:physiopathology* / Q000628:therapy; D062645:Percutaneous Coronary Intervention; D011446:Prospective Studies; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology*