title: Describing the potential crossreactome between mumps virus and spermatogenesis-associated proteins.
abstract: This study documents that mumps virus shares several peptide sequences with human proteins that, when altered, may be involved in oligospermia/azoospermia, sterility and testicular atrophy. Examples are sperm flagellar protein 2 and spermatogenesis and centriole-associated protein 1. The data invite to further investigate crossreactivity as a potential mechanism linking anti-mumps immune responses, alterations of spermatogenesis-associated antigens and male fertility disorders.
authors.affiliation: Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari 70126, Italy. dkanduc@gmail.com.
authors.forename: Darja
authors.initials: D
authors.lastname: Kanduc
mesh_terms: D000956:Antigens, Viral / Q000737:chemistry / Q000276:immunology*; D003429:Cross Reactions; D006801:Humans; D007248:Infertility, Male / Q000276:immunology / Q000821:virology; D008297:Male; D009109:Mumps virus / Q000276:immunology*; D010446:Peptide Fragments / Q000737:chemistry / Q000276:immunology; D020543:Proteome / Q000032:analysis* / Q000276:immunology; D029589:Seminal Plasma Proteins / Q000737:chemistry / Q000276:immunology*; D016415:Sequence Alignment; D020539:Sequence Analysis, Protein; D013091:Spermatogenesis / Q000276:immunology; D014764:Viral Proteins / Q000737:chemistry / Q000276:immunology
chemical_list: D000956:Antigens, Viral; D010446:Peptide Fragments; D020543:Proteome; D029589:Seminal Plasma Proteins; D014764:Viral Proteins