title: Lacosamide-induced atrial tachycardia in a child with hypoplastic left-heart syndrome: the importance of assessing additional proarrhythmic risks.
abstract: Antiepileptic medications have been reported to cause disturbances in cardiac conduction. Lacosamide decreases seizure burden by modulating sodium channels. Although it has been demonstrated to have few side effects, there have been reports of clinically significant cardiac conduction disturbances. We report the case of a child with hypoplastic left-heart syndrome and well-controlled multifocal atrial tachycardia who developed haemodynamically significant atrial tachycardia after receiving two doses of lacosamide.
authors.affiliation: Department of Cardiology,Children's Hospital of Wisconsin,Milwaukee,Wisconsin,United States of America.
authors.forename: Rohit S
authors.initials: RS
authors.lastname: Loomba
authors.affiliation: Department of Cardiology,Children's Hospital of Wisconsin,Milwaukee,Wisconsin,United States of America.
authors.forename: Anoop K
authors.initials: AK
authors.lastname: Singh
authors.affiliation: Department of Cardiology,Children's Hospital of Wisconsin,Milwaukee,Wisconsin,United States of America.
authors.forename: Joshua
authors.initials: J
authors.lastname: Kovach
authors.affiliation: Department of Cardiology,Children's Hospital of Wisconsin,Milwaukee,Wisconsin,United States of America.
authors.forename: Todd M
authors.initials: TM
authors.lastname: Gudausky
mesh_terms: D000081:Acetamides / Q000009:adverse effects*; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac; D002675:Child, Preschool; D015897:Comorbidity; D006801:Humans; D018636:Hypoplastic Left Heart Syndrome; D007555:Isoxazoles / Q000008:administration & dosage; D000078334:Lacosamide; D000077287:Levetiracetam; D008297:Male; D010889:Piracetam / Q000008:administration & dosage / Q000031:analogs & derivatives; D012640:Seizures / Q000188:drug therapy; D013616:Tachycardia, Sinus / Q000139:chemically induced*; D016896:Treatment Outcome; D000078305:Zonisamide
chemical_list: D000081:Acetamides; D000927:Anticonvulsants; D007555:Isoxazoles; D000077287:Levetiracetam; D000078305:Zonisamide; D000078334:Lacosamide; D010889:Piracetam
keywords: flecainide