title: [Cardiovascular diseases and osteoporosis: what is common?].
abstract: The review analyzes the possible effect of cardiac drugs on the course of osteoporosis (OP). The fact that atherosclerosis and OP share the mechanisms of development, among which the enhanced activity of the sympathetic part of the autonomic nervous system and endothelial dysfunction are most important, is beyond question now. In this connection, beta-adrenoblockers, nebivolol in particular, attract attention. Nebivolol is known to be a selective beta1-adrenoblocker that has an additional vasodilator property, by stimulating the synthesis of nitric oxide. This may serve to increase bone mineral density and slow down the progression of OP. At the same time, most investigations in this area are retrospective therefore final conclusions call for randomized prospective studies that will be able to evaluate more objectively the effect of cardiac drugs on the prevention of OP or its progression delay.
authors.forename: I L
authors.initials: IL
authors.lastname: Fedorchenko
authors.forename: D V
authors.initials: DV
authors.lastname: Nebieridze
authors.forename: A S
authors.initials: AS
authors.lastname: Safarian
authors.forename: I A
authors.initials: IA
authors.lastname: Skripnikova
authors.forename: K E
authors.initials: KE
authors.lastname: Sobchenko
mesh_terms: D001578:Benzopyrans / Q000494:pharmacology*; D015519:Bone Density / Q000187:drug effects; D002317:Cardiovascular Agents / Q000494:pharmacology; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000378:metabolism / Q000503:physiopathology; D004983:Ethanolamines / Q000494:pharmacology*; D006801:Humans; D000068577:Nebivolol; D009569:Nitric Oxide / Q000096:biosynthesis; D010024:Osteoporosis / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control; D012189:Retrospective Studies; D014665:Vasodilator Agents / Q000494:pharmacology; D014666:Vasomotor System / Q000378:metabolism / Q000503:physiopathology
chemical_list: D001578:Benzopyrans; D002317:Cardiovascular Agents; D004983:Ethanolamines; D014665:Vasodilator Agents; D000068577:Nebivolol; D009569:Nitric Oxide