title: Failure of heterogeneous amyloid-enhancing factor in geriatric squirrel monkeys (Saimiri boliviensis).
abstract: BACKGROUND
  Cross-species transmission of AA amyloidosis between primates and other animals has not been previously reported.
  
  
  METHODS
  Eight geriatric squirrel monkeys were intravenously administered chimpanzee, bovine, or chicken amyloid fibrils and simultaneously received inflammatory stimulation.
  
  
  RESULTS
  AA amyloid deposition was not detected in any of the monkeys histopathologically or immunohistochemically.
  
  
  CONCLUSIONS
  These results suggest that heterogeneous AA amyloidosis may not be easily transmitted into primates.
authors.affiliation: Laboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, Tokyo, Japan.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Murakami
authors.forename: Kanata
authors.initials: K
authors.lastname: Ibi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kuraishi
authors.forename: Shosaku
authors.initials: S
authors.lastname: Hattori
authors.forename: Chieko
authors.initials: C
authors.lastname: Kai
authors.forename: Naotaka
authors.initials: N
authors.lastname: Ishiguro
authors.forename: Tokuma
authors.initials: T
authors.lastname: Yanai
mesh_terms: D061605:Administration, Intravenous / Q000662:veterinary; D000375:Aging; D000682:Amyloid / Q000008:administration & dosage / Q000378:metabolism*; D000686:Amyloidosis / Q000209:etiology / Q000628:therapy / Q000662:veterinary*; D000818:Animals; D002417:Cattle / Q000502:physiology; D002645:Chickens / Q000502:physiology; D005260:Female; D006023:Glycoproteins / Q000008:administration & dosage / Q000378:metabolism*; D008297:Male; D002679:Pan troglodytes / Q000502:physiology; D012453:Saimiri / Q000502:physiology*
chemical_list: D000682:Amyloid; D006023:Glycoproteins; C046748:amyloid enhancing factor
keywords: AA amyloidosis; amyloid A; amyloid β; cattle; chicken; chimpanzee; transmission