title: Peripheral primitive neuroectodermal tumor of the dura in a 51-year-old woman following intensive treatment for breast cancer.
abstract: METHODS
  Female, 51.
  
  
  METHODS
  Ewing sarcoma.
  
  
  METHODS
  Visual disturbances.
  
  
  METHODS
  -.
  
  
  METHODS
  -.
  
  
  METHODS
  Oncology.
  
  
  OBJECTIVE
  Rare disease.
  
  
  BACKGROUND
  Primitive neuroectodermal tumor/Ewing sarcoma (PNET/EWS) is a round blue cell sarcoma that shows varying degrees of neuroectodermal differentiation. PNET/EWS as a primary intracranial tumor is extremely uncommon.
  
  
  METHODS
  We report a unique case of peripheral PNET presenting as an intracranial mass in an adult following chemotherapy and radiotherapy for a solid tumor. A 51-year-old woman with previously treated left breast cancer was evaluated for a newly developed brain mass. She underwent craniotomy with resection. Surgical pathology was consistent with a peripheral PNET/EWS with Ewing sarcoma gene translocation. She was treated appropriately with vincristine, cyclophosphamide, and doxorubicin (later dactinomycin) alternating with ifosfamide and etoposide.
  
  
  CONCLUSIONS
  Although development of PNET/EWS presenting along the CNS is exceedingly rare in adults, establishing the proper diagnosis of this "small blue cell tumor" is critical. The further distinction between central PNET and peripheral PNET can greatly impact both prognosis and treatment. Our case also highlights the importance of considering the impact of prior intensive therapies, including radiation and chemotherapy, on predisposing to future PNET/EWS.
authors.affiliation: Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA, U.S.A.
authors.forename: Marion
authors.initials: M
authors.lastname: Cole
authors.affiliation: Department of Pathology and Laboratory Medicine, Temple University Hospital, Philadelphia, PA, U.S.A.
authors.forename: Shobha
authors.initials: S
authors.lastname: Parajuli
authors.affiliation: Department of Neurosurgery, Temple University School of Medicine, Philadelphia, PA, U.S.A.
authors.forename: Douglas
authors.initials: D
authors.lastname: Laske
authors.affiliation: Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA, U.S.A.
authors.forename: Lori
authors.initials: L
authors.lastname: Goldstein
authors.affiliation: Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA, U.S.A.
authors.forename: Tara
authors.initials: T
authors.lastname: Morrison
authors.affiliation: Department of Pathology and Laboratory Medicine, Temple University Hospital, Philadelphia, PA, U.S.A.
authors.forename: Abir
authors.initials: A
authors.lastname: Mukherjee
authors.affiliation: Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA, U.S.A.
authors.forename: Kathryn
authors.initials: K
authors.lastname: Tumelty
authors.affiliation: Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA, U.S.A.
authors.forename: Eric
authors.initials: E
authors.lastname: Tetzlaff
authors.affiliation: Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA, U.S.A.
authors.forename: Margaret
authors.initials: M
authors.lastname: von Mehren
authors.affiliation: Department of Pathology and Laboratory Medicine, Temple University Hospital, Philadelphia, PA, U.S.A.
authors.forename: Susan
authors.initials: S
authors.lastname: Inniss
mesh_terms: D001943:Breast Neoplasms / Q000628:therapy*; D003131:Combined Modality Therapy; D003399:Craniotomy / Q000379:methods; D003937:Diagnosis, Differential; D004388:Dura Mater; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D008875:Middle Aged; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery
keywords: Central Nervous System; Neuroectodermal Tumors, Primitive, Peripheral; Sarcoma, Ewing