title: Copper-catalyzed aerobic decarboxylative sulfonylation of cinnamic acids with sodium sulfinates: stereospecific synthesis of (E)-alkenyl sulfones.
abstract: A copper-catalyzed aerobic decarboxylative sulfonylation of alkenyl carboxylic acids with sodium sulfinates is developed. This study offers a new and expedient strategy for stereoselective synthesis of (E)-alkenyl sulfones that are widely present in biologically active natural products and therapeutic agents. Moreover, the transformation is proposed to proceed via a radical process and exhibits a broad substrate scope and good functional group tolerance.
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, Advanced Catalytic Engineering Research Center of the Ministry of Education, College of Chemistry and Chemical Engineering, Hunan University , Changsha, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Jiang
authors.forename: Bin
authors.initials: B
authors.lastname: Xu
authors.forename: Jing
authors.initials: J
authors.lastname: Jia
authors.forename: An
authors.initials: A
authors.lastname: Zhao
authors.forename: Yu-Rou
authors.initials: YR
authors.lastname: Zhao
authors.forename: Ying-Ying
authors.initials: YY
authors.lastname: Li
authors.forename: Na-Na
authors.initials: NN
authors.lastname: He
authors.forename: Can-Cheng
authors.initials: CC
authors.lastname: Guo
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D002934:Cinnamates / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D003653:Decarboxylation; D015394:Molecular Structure; D012964:Sodium / Q000737:chemistry*; D013441:Sulfinic Acids / Q000737:chemistry*; D013450:Sulfones / Q000138:chemical synthesis
chemical_list: D002264:Carboxylic Acids; D002934:Cinnamates; D013441:Sulfinic Acids; D013450:Sulfones; C029010:cinnamic acid; D003300:Copper; D012964:Sodium