title: Clinical significance of POU5F1P1 rs10505477 polymorphism in Chinese gastric cancer patients receving cisplatin-based chemotherapy after surgical resection.
abstract: This study aimed to investigate the association between POU class5 homeobox 1 pseudogene 1 gene (POU5F1P1) rs10505477 polymorphism and the prognosis of Chinese gastric cancer patients, who received cisplatin-based chemotherapy after surgical resection. POU5F1P1 rs10505477 was genotyped using the SNaPshot method in 944 gastric cancer patients who received gastrectomy. The association of rs10505477 G>A polymorphism with the progression and prognosis in gastric cancer patients was statistically analyzed using the SPSS version 18.0 for Windows. The results reveal that rs10505477 polymorphism has a negatively effect on the overall survival of gastric cancer patients in cisplatin-based chemotherapy subgroup (HR=1.764, 95% CI=1.069-2.911, p=0.023). Our preliminary study indicates for the first time that POU5F1P1 rs10505477 is correlated with survival of gastric cancer patients who receving cisplatin-based chemotherapy after gastrectomy. Further studies are warranted to investigate the mechanism and to verify our results in different populations.
authors.affiliation: Department of Oncology, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, China. shenlilimao2012@163.com.
authors.forename: Lili
authors.initials: L
authors.lastname: Shen
authors.affiliation: Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, 818 East Tianyuan Road, Nanjing 211166, China. dumulong@163.com.
authors.forename: Mulong
authors.initials: M
authors.lastname: Du
authors.affiliation: Department of Oncology, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, China. wangchun850526@hotmail.com.
authors.forename: Chun
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Oncology, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, China. gu_dongying@sina.com.
authors.forename: Dongying
authors.initials: D
authors.lastname: Gu
authors.affiliation: Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, 818 East Tianyuan Road, Nanjing 211166, China. meilin_w@163.com.
authors.forename: Meilin
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Oncology, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, China. jhcxy1225@126.com.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Oncology, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, China. zhaoting19900912@163.com.
authors.forename: Tingting
authors.initials: T
authors.lastname: Zhao
authors.affiliation: Department of Oncology, Nantong Tumor Hospital, Nantong 226000, 30 Tongyang North Road, China. yjsnj1231@hotmail.com.
authors.forename: Xunlei
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Surgery, Yixing People's Hospital, 75 Tongzhenguan Road, Yixing 214200, China. shelly37319@126.com.
authors.forename: Yongfei
authors.initials: Y
authors.lastname: Tan
authors.affiliation: Department of Oncology, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, China. huoxinying2008@126.com.
authors.forename: Xinying
authors.initials: X
authors.lastname: Huo
authors.affiliation: Department of General Surgery, Yixing Tumor Hospital, 45 Dongshan East Road, Yixing 214200, China. gongweida2010@gmail.com.
authors.forename: Weida
authors.initials: W
authors.lastname: Gong
authors.affiliation: Department of Oncology, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, China. michelle.xuzhi@gmail.com.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Xu
authors.affiliation: Department of Oncology, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, China. jinfeichen@sohu.com.
authors.forename: Jinfei
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, 818 East Tianyuan Road, Nanjing 211166, China. drzdzhang@gmail.com.
authors.forename: Zhengdong
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics*; D016022:Case-Control Studies; D002945:Cisplatin / Q000627:therapeutic use*; D005260:Female; D005743:Gastrectomy; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D018398:Homeodomain Proteins; C588352:POU5F1B protein, human; D002945:Cisplatin