title: Communication, the centrosome and the immunological synapse.
abstract: Recent findings on the behaviour of the centrosome at the immunological synapse suggest a critical role for centrosome polarization in controlling the communication between immune cells required to generate an effective immune response. The features observed at the immunological synapse show parallels to centrosome (basal body) polarization seen in cilia and flagella, and the cellular communication that is now known to occur at all of these sites.
authors.affiliation: Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 OXY, UK.
authors.forename: Jane C
authors.initials: JC
authors.lastname: Stinchcombe
authors.affiliation: Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 OXY, UK gg305@cam.ac.uk.
authors.forename: Gillian M
authors.initials: GM
authors.lastname: Griffiths
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002450:Cell Communication / Q000502:physiology*; D016764:Cell Polarity; D018385:Centrosome / Q000502:physiology*; D002923:Cilia / Q000502:physiology*; D007107:Immune System / Q000502:physiology*; D054992:Immunological Synapses / Q000502:physiology*; D018448:Models, Immunological
keywords: centrosome; cilia; immunological synapse; killing