title: [The risk of neoplastic processes transformation in cervix uteri].
abstract: There was performed a comparative analysis of quantitative load and physical status of human papillomavirus (HPV) type 16 in groups of patients with cervical intraepithelial neoplasia (CIN)--25 people and cervical cancer (CC)--85 people. According to the analysis there were selected criteria appropriate to a combination of adverse factors that characterized HPV- infection and at the same time estimated both quantitative load and physical status of the virus: high viral load (> 6,5 lg copies of HPV DNA per 100000 cells) in episomal form or low load (< 6,5 lg copies of HPV DNA per 100000 cells) in integrated form of the virus. According to calculations a relative chance of appearing of CC in CIN patients with unfavorable combination of factors was 7,5 times higher than in other patients.
authors.forename: V I
authors.initials: VI
authors.lastname: Kiseleva
authors.forename: L I
authors.initials: LI
authors.lastname: Krikunova
authors.forename: L S
authors.initials: LS
authors.lastname: Mkrtchian
authors.forename: L V
authors.initials: LV
authors.lastname: Liubina
authors.forename: G P
authors.initials: GP
authors.lastname: Beziaeva
authors.forename: L V
authors.initials: LV
authors.lastname: Panarina
authors.forename: I A
authors.initials: IA
authors.lastname: Zamuliaeva
mesh_terms: D000328:Adult; D000368:Aged; D002471:Cell Transformation, Neoplastic; D002584:Cervix Uteri / Q000473:pathology* / Q000821:virology*; D004279:DNA, Viral / Q000302:isolation & purification; D005260:Female; D052162:Human papillomavirus 16 / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D030361:Papillomavirus Infections / Q000150:complications* / Q000821:virology; D011379:Prognosis; D012306:Risk; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000821:virology*; D019562:Viral Load; D002578:Uterine Cervical Dysplasia / Q000821:virology*
chemical_list: D004279:DNA, Viral