title: Uptake of yeast cells in the Atlantic salmon (Salmo salar L.) intestine.
abstract: The intestinal mucosa is an important port of entry for many pathogens. Information of antigen uptake mechanisms is essential to understand and to possibly prevent infections. In teleosts, several studies have aimed at investigating particulate uptake in the gastrointestinal system that seems to vary dependent on fish species and antigen. In the present study, particulate uptake in the Atlantic salmon intestine by anal intubation of yeast cells has been investigated. In the anal intubated fish, yeast were found in the epithelium close to nuclei of macrophage-like cells and inside large mononuclear cells in the intestinal lumen, indicating uptake and possible transport of large antigen particles over the epithelium by macrophage-like cells.
authors.affiliation: Department of Basic Sciences and Aquatic Medicine, Faculty of Veterinary Medicine and Biosciences, School of Veterinary Medicine, Norwegian University of Life Sciences, Oslo, Norway. Electronic address: guro.lokka@nmbu.no.
authors.forename: Guro
authors.initials: G
authors.lastname: Løkka
authors.affiliation: Norwegian Veterinary Institute, Oslo, Norway. Electronic address: knut.falk@vetinst.no.
authors.forename: Knut
authors.initials: K
authors.lastname: Falk
authors.affiliation: Department of Basic Sciences and Aquatic Medicine, Faculty of Veterinary Medicine and Biosciences, School of Veterinary Medicine, Norwegian University of Life Sciences, Oslo, Norway. Electronic address: lars.austbo@nmbu.no.
authors.forename: Lars
authors.initials: L
authors.lastname: Austbø
authors.affiliation: Department of Basic Sciences and Aquatic Medicine, Faculty of Veterinary Medicine and Biosciences, School of Veterinary Medicine, Norwegian University of Life Sciences, Oslo, Norway. Electronic address: erling.o.koppang@nmbu.no.
authors.forename: Erling Olaf
authors.initials: EO
authors.lastname: Koppang
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology / Q000378:metabolism; D000946:Antigens, Fungal / Q000276:immunology; D001692:Biological Transport; D007422:Intestines / Q000166:cytology / Q000276:immunology / Q000382:microbiology; D008264:Macrophages / Q000276:immunology; D012441:Saccharomyces cerevisiae; D020317:Salmo salar / Q000276:immunology* / Q000382:microbiology*
chemical_list: D000946:Antigens, Fungal
keywords: Anal intubation; Antigen uptake; Macrophage-like cells; Saccharomyces cerevisiae