title: Optimizing the cost-effectiveness of treatment for chronic kidney disease-mineral and bone disorder.
abstract: Chronic kidney disease-mineral and bone disorder (CKD-MBD) is an important risk factor in patients with CKD, and some medications for treating CKD-MBD have been recently marketed. Because assessment of health-care cost-effectiveness is growing in importance with increases in health expenditures, several cost-effectiveness analyses for new medications such as sevelamer, lanthanum carbonate, cinacalcet hydrochloride, and paricalcitol have been conducted. The results of these analyses have stimulated discussion on the efficient use of these medications and, in some cases, have affected treatment recommendation. However, most of these studies had methodological problems, one of them being that the effectiveness of medications was estimated based on changes of surrogate parameters, such as vascular calcification or serum biochemistry values. Furthermore, even if cost-effectiveness analyses were based on a given clinical trial, the results might differ from country to country. To provide greater health benefits under limited health expenditures based on the results of cost-effectiveness analyses, it is necessary to confirm the effectiveness of medications through well-designed clinical trials having mortality as the primary end point. In addition, cost-effectiveness analyses need to be performed separately for each country.
authors.affiliation: Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine , Kobe, Japan.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Goto
authors.affiliation: Division of Nephrology, Endocrinology and Metabolism, Tokai University School of Medicine , Isehara, Japan.
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Komaba
authors.affiliation: Division of Nephrology, Endocrinology and Metabolism, Tokai University School of Medicine , Isehara, Japan.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Fukagawa
authors.affiliation: Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine , Kobe, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Nishi
keywords: CKD-MBD; cost-effectiveness analysis; hyperphosphatemia; secondary hyperparathyroidism