title: Drug encapsulation and release by mesoporous silica nanoparticles: the effect of surface functional groups.
abstract: Mesoporous silica nanoparticles (MSNPs) have been widely used as drug carriers for stimuli-responsive drug delivery. Herein, a catalysis screening technique was adopted for analyzing the effects of chain length, terminal group, and density of disulfide-appended functional ligands on the surface of MSNPs on drug-loading capacity and glutathione-triggered drug-release kinetics. The ligand with an intermediate length (5 carbon atoms) and a bulky terminal group (cyclohexyl) that complexes with theβ-cyclodextrin ring showed the highest drug loading capacity as well as good release kinetics. In addition, decreasing the surface coverage of the functional ligands led to an enhancement in drug release. In vitro drug-delivery experiments on a melanoma cell line (B16-F10) by using the functionalized MSNPs further supported the conclusion. The results obtained may serve as a general guide for developing more effective MSNP systems for drug delivery.
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371 (Singapore) http://www.ntu.edu.sg/home/zhaoyanli/
authors.forename: Si Yu
authors.initials: SY
authors.lastname: Tan
authors.forename: Chung Yen
authors.initials: CY
authors.lastname: Ang
authors.forename: Peizhou
authors.initials: P
authors.lastname: Li
authors.forename: Qi Ming
authors.initials: QM
authors.lastname: Yap
authors.forename: Yanli
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D045744:Cell Line, Tumor; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage*; D006801:Humans; D007700:Kinetics; D008545:Melanoma / Q000188:drug therapy; D053758:Nanoparticles / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D000903:Antibiotics, Antineoplastic; D003692:Delayed-Action Preparations; D012822:Silicon Dioxide; D004317:Doxorubicin
keywords: drug delivery; ligand effects; mesoporous silica nanoparticles; release kinetics; surface functionalization