title: Left atrial function and maximum volume as determined by MDCT are independently associated with atrial fibrillation.
abstract: OBJECTIVE
  To assess whether left atrial (LA) volume, function, and diameter as determined by multidetector computed tomography (MDCT) are associated with the presence and chronicity of atrial fibrillation (AF).
  
  
  METHODS
  A total of 232 subjects, 156 with AF (43 with chronic and 113 with paroxysmal) and 76 normal subjects, formed the study population. AF subjects underwent MDCT of the pulmonary veins and LA, and normal subjects underwent coronary computed tomography (CT), on which LA volume, function, and diameter were measured. Associations between each MDCT LA parameter and presence and chronicity of AF were assessed using logistic regression analysis.
  
  
  RESULTS
  The indexed LA maximum volume (odds ratio [OR]=2.42; 95% confidence interval [CI], 1.43-4.08; P=.0009) was significantly associated with chronicity and presence of AF (OR=1.06; 95% CI, 1.03-1.10; P=.0003) after adjustment for traditional risk factors. The LA function was associated with presence of AF (OR=0.93; 95% CI, 0.89-0.97; P=.0005), but not with AF chronicity (OR=1.12; 95% CI, 0.93-1.33; P=.21).
  
  
  CONCLUSIONS
  Decreased LA function is associated with presence of AF, and increased LA maximum volume is associated with presence and chronicity of AF, independent of traditional risk factors.
authors.affiliation: Department of Radiology, University of Michigan Hospitals, B1 132H Taubman, Center/5302, 1500 E. Medical Center Drive, Ann Arbor, MI, 48109-5302. Electronic address: jstoanov@med.umich.edu.
authors.forename: Jadranka
authors.initials: J
authors.lastname: Stojanovska
authors.affiliation: Division of Cardiothoracic Radiology, Department of Radiology, University of Michigan Health System, Ann Arbor, Michigan.
authors.forename: Paul
authors.initials: P
authors.lastname: Cronin
authors.affiliation: Division of Cardiothoracic Radiology, Department of Radiology, University of Michigan Health System, Ann Arbor, Michigan.
authors.forename: Barry H
authors.initials: BH
authors.lastname: Gross
authors.affiliation: Division of Cardiothoracic Radiology, Department of Radiology, University of Michigan Health System, Ann Arbor, Michigan.
authors.forename: Ella A
authors.initials: EA
authors.lastname: Kazerooni
authors.affiliation: Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan.
authors.forename: Alex
authors.initials: A
authors.lastname: Tsodikov
authors.affiliation: Division of Cardiothoracic Radiology, Department of Radiology, University of Michigan Health System, Ann Arbor, Michigan.
authors.forename: Luba
authors.initials: L
authors.lastname: Frank
authors.affiliation: Division of Cardiovascular Medicine, Department of Internal Medicine, Cardiovascular Center, University of Michigan Health System, Ann Arbor, Michigan.
authors.forename: Hakan
authors.initials: H
authors.lastname: Oral
mesh_terms: D000328:Adult; D000368:Aged; D001281:Atrial Fibrillation / Q000000981:diagnostic imaging*; D016279:Atrial Function, Left / Q000502:physiology*; D002908:Chronic Disease; D015331:Cohort Studies; D003287:Contrast Media; D003430:Cross-Sectional Studies; D004562:Electrocardiography / Q000379:methods; D005260:Female; D006325:Heart Atria / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography / Q000379:methods*; D016017:Odds Ratio; D009929:Organ Size; D011667:Pulmonary Veins / Q000000981:diagnostic imaging; D011856:Radiographic Image Enhancement / Q000379:methods; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012307:Risk Factors; D014283:Triiodobenzoic Acids
chemical_list: D003287:Contrast Media; D014283:Triiodobenzoic Acids; C044834:iodixanol
keywords: Atrial fibrillation; left atrial function; left atrial maximum diameter; left atrial maximum volume; left atrial minimum volume