title: Synthesis of gold nanorods and their functionalization with bovine serum albumin for optical hyperthermia.
abstract: Although gold nanorods (GNRs) have been investigated extensively for optical hyperthermia therapies, the synthesis of rods is far from ideal. In this report, we optimized the synthesis of gold nanorods using hydroquinone as a reducing agent. Compared with the GNRs prepared by traditional ways, the as-synthesized rods have a flexibly tunable size and wider range of longitudinal surface plasmon resonance (LSPR). Furthermore, a series of small-length gold nanorods with length ranging from 30 to 90 nm were synthesized and they are more suitable for in vivo biomedical applications. Finally, we exploited a convenient approach for preparing water-soluble GNRs with less toxicity, better dispersion and flexible functionalization by exchanging hexadecyltrimethylammonium bromide (CTAB) on the surface of the rods with carboxylated bovine serum albumin (BSA) derivative, the BSA modified GNRs showed significant anticancer efficacy through near infrared (NIR) hyperthermia. We believe that the as-prepared gold nanorods will find promising applications in biomedical fields, especially in cancer therapy.
authors.forename: Liming
authors.initials: L
authors.lastname: Zhang
authors.forename: Kai
authors.initials: K
authors.lastname: Xia
authors.forename: Ying-Ying
authors.initials: YY
authors.lastname: Bai
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Tang
authors.forename: Yan
authors.initials: Y
authors.lastname: Deng
authors.forename: Juan
authors.initials: J
authors.lastname: Chen
authors.forename: Weiping
authors.initials: W
authors.lastname: Qian
authors.forename: He
authors.initials: H
authors.lastname: Shen
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Zhang
authors.forename: Shenghong
authors.initials: S
authors.lastname: Ju
authors.forename: Nongyue
authors.initials: N
authors.lastname: He
mesh_terms: D000818:Animals; D002460:Cell Line; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D000077286:Cetrimonium; D002593:Cetrimonium Compounds; D006046:Gold / Q000737:chemistry* / Q000494:pharmacology; D006358:Hot Temperature; D006801:Humans; D006873:Hydroquinones / Q000737:chemistry; D051379:Mice; D043942:Nanotubes / Q000737:chemistry*; D010789:Phototherapy; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D023041:Xenograft Model Antitumor Assays
chemical_list: D002593:Cetrimonium Compounds; D006873:Hydroquinones; D012710:Serum Albumin, Bovine; D006046:Gold; C031927:hydroquinone; D000077286:Cetrimonium