title: EGFR-mutated lung cancer in Li-Fraumeni syndrome.
abstract: This is a revised case report of a 52 year old Caucasian female with Li-Fraumeni syndrome with a rare TP53 mutation, who was treated for breast cancer and later developed epidermal growth factor receptor (EGFR) mutated non-small cell lung cancer.
authors.affiliation: Department of Medical Oncology, Guy's and St. Thomas' NHS Foundation Trust, London, UK. Electronic address: v.michalarea@nhs.net.
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Michalarea
authors.affiliation: Department of Medical Oncology, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
authors.forename: Matthew
authors.initials: M
authors.lastname: Calcasola
authors.affiliation: Department of Cellular Pathology, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Cane
authors.affiliation: Department of Molecular Pathology, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
authors.forename: Khalid
authors.initials: K
authors.lastname: Tobal
authors.affiliation: Department of Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
authors.forename: Louise
authors.initials: L
authors.lastname: Izatt
authors.affiliation: Department of Medical Oncology, Guy's and St. Thomas' NHS Foundation Trust, London, UK; Division of Cancer Studies, King's College London, London, UK. Electronic address: james.spicer@kcl.ac.uk.
authors.forename: James
authors.initials: J
authors.lastname: Spicer
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000473:pathology / Q000601:surgery; D004252:DNA Mutational Analysis; D066246:ErbB Receptors / Q000235:genetics*; D000069347:Erlotinib Hydrochloride; D005260:Female; D006801:Humans; D016864:Li-Fraumeni Syndrome / Q000150:complications* / Q000235:genetics*; D008175:Lung Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D008875:Middle Aged; D009154:Mutation; D011799:Quinazolines / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D016159:Tumor Suppressor Protein p53 / Q000235:genetics; D055815:Young Adult
chemical_list: D011799:Quinazolines; D016159:Tumor Suppressor Protein p53; D000069347:Erlotinib Hydrochloride; D066246:ErbB Receptors
keywords: EGFR mutations; Li-Fraumeni syndrome; Non-small cell lung cancer; TP53