title: Protein overexpression of CIRP and TLR4 in oral squamous cell carcinoma: an immunohistochemical and clinical correlation analysis.
abstract: Oral squamous cell carcinoma (OSCC) is the most common head and neck malignancy. Here, we evaluated the expression of cold-inducible RNA-binding protein (CIRP) and toll-like receptors 4 (TLR4) in OSCC tissues with immunohistochemistry. Using biostatistical methods designed to assess the impact of the expression of CIRP and TLR4 on the prognosis of patients with OSCC and relate that expression to the clinicopathological characteristics of these patients. For the first time, we demonstrated that the expression of CIRP and TLR4 was increased in OSCC and that high levels of CIRP or TLR4 expression were associated with a short survival rate. In addition, we were surprised to find that the levels of expression of CIRP and TLR4 were very similar. The goal of this study was to evaluate whether these two genes may provide clues as to the regulatory mechanisms of OSCC, serve as prognostic markers and establish a new direction for further studies of these biological mechanisms.
authors.affiliation: Department of Oral and Maxillofacial Surgery, College of Stomatology, Xi'an Jiaotong University, Number 98, Xiwu Road, Xi'an, 710004, Shaanxi, People's Republic of China.
authors.forename: Wen Hao
authors.initials: WH
authors.lastname: Ren
authors.forename: Lin Mei
authors.initials: LM
authors.lastname: Zhang
authors.forename: Huai Qin
authors.initials: HQ
authors.lastname: Liu
authors.forename: Ling
authors.initials: L
authors.lastname: Gao
authors.forename: Cheng
authors.initials: C
authors.lastname: Chen
authors.forename: Cui
authors.initials: C
authors.lastname: Qiang
authors.forename: Xiao Long
authors.initials: XL
authors.lastname: Wang
authors.forename: Chang Yang
authors.initials: CY
authors.lastname: Liu
authors.forename: Shao Ming
authors.initials: SM
authors.lastname: Li
authors.forename: Chen
authors.initials: C
authors.lastname: Huang
authors.forename: Hong
authors.initials: H
authors.lastname: Qi
authors.forename: Ke Qian
authors.initials: KQ
authors.lastname: Zhi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D011379:Prognosis; D016601:RNA-Binding Proteins / Q000378:metabolism*; D015996:Survival Rate; D051197:Toll-Like Receptor 4 / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; C491390:CIRBP protein, human; D016601:RNA-Binding Proteins; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4