title: [HCo(CO)₄]-catalyzed three-component cycloaddition of epoxides, imines, and carbon monoxide: facile construction of 1,3-oxazinan-4-ones.
abstract: The three-component [3+2+1] cycloaddition of epoxides, imines, and carbon monoxide to produce 1,3-oxazinan-4-ones has been developed by using [HCo(CO)4] as the catalyst. The reaction occurs for a wide variety of imines and epoxides, under 60 bar of CO pressure at 50 °C, to produce 1,3-oxazinan-4-ones with different substitution patterns in high yields, and provides an efficient and atom-economic route to heterocycles from simple and readily available starting materials. A plausible mechanism involves [HCo(CO)4]-induced ring-opening of the epoxide, followed by sequential addition of carbon monoxide and the imine, and then ring closure to form the product accompanied by regeneration of [HCo(CO)4].
authors.affiliation: State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering, and Department of Chemistry, Nankai University, Tianjin, 300071 (P.R. China).
authors.forename: Lixia
authors.initials: L
authors.lastname: Liu
authors.forename: Huailin
authors.initials: H
authors.lastname: Sun
keywords: cobalt; cycloaddition; epoxides; heterocycles; multicomponent reactions