title: Thermosensitive hydrogel used in dual drug delivery system with paclitaxel-loaded micelles for in situ treatment of lung cancer.
abstract: In this study, an in situ gel-based dual drug delivery system (PEG-PCL-PEG/DDP+MPEG-PCL/PTX, abbreviated as PDMP) was prepared through the combination of a cisplatin (DDP)-containing thermosensitive hydrogel (PEG-PCL-PEG/DDP, PECE/DDP) and paclitaxel (PTX)-loaded polymeric micelles (average diameter of 20.1nm). PDMP is a free-flowing solution at room temperature and forms a stationary gel at body temperature, allowing it to serve as a drug depot for the in situ treatment of lung cancer. For in vivo experiments, the xenografted lung cancer model was used to evaluate the anti-tumor efficacy of the PDMP. The results suggested that PDMP is effective at inhibiting tumor growth and prolonging the survival time of tumor-bearing BALB/c nude mice. The survival time of the PDMP-treated group (53 days) is significantly higher than that of other groups (40 days from the free DDP+PTX group, 26 days from the blank PECE group, 25 days from the normal saline group, p<0.05). Immunohistochemical analysis revealed that tumors in the PDMP group had fewer microvessels and lower proliferation activity compared with those of the control group. Thus, PDMP may have great potential for in situ treatment of lung cancer by minimally invasive injection methods.
authors.affiliation: Department of Clinical Medicine, Xiangya School of Medicine, Central South University, Changsha, China.
authors.forename: ZhouXue
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Department of Oncology, The Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China. Electronic address: zouxiaoyan84@163.com.
authors.forename: XiaoYan
authors.initials: X
authors.lastname: Zou
authors.affiliation: Department of Oncology, The Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China.
authors.forename: LingLin
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Oncology, The Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Lin
authors.affiliation: Department of Oncology, The Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Fan
authors.affiliation: Department of Oncology, The Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.affiliation: Department of Oncology, The Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China.
authors.forename: XiaoYang
authors.initials: X
authors.lastname: Sun
authors.affiliation: Department of Nuclear Medicine, The Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wan
authors.affiliation: Department of Nuclear Medicine, The Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Oncology, The Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China. Electronic address: shaozhifu513@163.com.
authors.forename: ShaoZhi
authors.initials: S
authors.lastname: Fu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000737:chemistry; D049109:Cell Proliferation; D016503:Drug Delivery Systems; D020100:Hydrogels; D008175:Lung Neoplasms / Q000098:blood supply / Q000188:drug therapy* / Q000473:pathology; D008823:Micelles; D009389:Neovascularization, Pathologic / Q000188:drug therapy; D017239:Paclitaxel / Q000008:administration & dosage* / Q000737:chemistry; D010316:Particle Size
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D020100:Hydrogels; D008823:Micelles; D017239:Paclitaxel
keywords: Cisplatin; Lung cancer; Micelles; Paclitaxel; Thermosensitive hydrogel