title: Coronary triglyceride deposition in contemporary advanced diabetics.
abstract: It is of importance to clarify pathophysiology of diabetic heart diseases such as heart failure and coronary artery disease. We reported a novel clinical phenotype called triglyceride deposit cardiomyovasculopathy (TGCV), showing aberrant TG accumulation in both coronary arteries and myocardium, in a cardiac transplant recipient. Here, we examined autopsied diabetics for TG deposition in cardiovasculature. Consecutive series of hearts from advanced diabetes mellitus (DM) subjects (DM group: DMG, n = 20) and those from age- and sex-matched non-diabetic controls (non DM group: NDMG, n = 20) were examined. The diagnostic criteria of 'advanced DM' was made based on 2014 Clinical Practice Recommendations proposed by the American Diabetes Association. The mean duration of DM was 15.8 years. All DMG suffered from heart diseases including coronary artery diseases and 14 subjects had multi-vessel disease. Tissue TG contents were measured biochemically. Coronary arterial TG contents was significantly higher in DMG compared with NDMG. Spatial distribution of TG in transverse sections of coronary arteries showed TG deposition mainly in smooth muscle cells by Imaging Mass Spectrometry. Abundant TG deposition in coronary artery might be associated with advanced DM.
authors.affiliation: Department of Pathology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Zaima
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Hirano
authors.forename: Masayuki
authors.initials: M
authors.lastname: Mano
authors.forename: Kunihisa
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Sohsuke
authors.initials: S
authors.lastname: Yamada
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: Akira
authors.initials: A
authors.lastname: Suzuki
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kanzaki
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Hamasaki
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Kotani
authors.forename: Seiya
authors.initials: S
authors.lastname: Kato
authors.forename: Hironori
authors.initials: H
authors.lastname: Nagasaka
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Setou
authors.forename: Hatsue
authors.initials: H
authors.lastname: Ishibashi-Ueda
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003327:Coronary Disease / Q000150:complications / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D003331:Coronary Vessels / Q000378:metabolism*; D048909:Diabetes Complications / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009130:Muscle, Smooth / Q000473:pathology; D014280:Triglycerides / Q000378:metabolism*
chemical_list: D014280:Triglycerides
keywords: atherosclerosis; congestive heart failure; coronary artery disease; diabetes mellitus; triglyceride