title: The role of tenofovir in preventing and treating hepatitis B virus (HBV) reactivation in immunosuppressed patients. A real life experience from a tertiary center.
abstract: OBJECTIVE
  Patients who present HBV reactivation during immunosuppressive treatment are prone to develop life threatening decompensation of the liver function, therefore prophylaxis and treatment are strongly recommended. So far there are no data regarding the role of tenofovir in this context. Therefore, the aim of our study was to describe our "real life" experience with the use of tenofovir (TDF) in patients who underwent immunosuppressive treatment.
  
  
  RESULTS
  38 patients with immunosuppression received antiviral treatment with tenofovir (25 patients as prophylaxis and 13 patients as treatment of HBV reactivation). In all 25 patients in whom prophylactic treatment with tenofovir was administered no HBV flare occurred during immunosuppression and the levels of serum HBV-DNA became or remained undetectable during the follow up period (mean follow up 17.2 months, range 6-54). One patient experienced HBsAg seroconversion. In the 13 patients who exhibited HBV reactivation TDF treatment resulted in complete biochemical and virological response within 6 months except two patients with high pretreatment HBV-DNA levels who became HBV-DNA negative at 9 months. No exacerbation of liver disease or liver related death has been observed. One patient who presented with decompensated cirrhosis during HBV reactivation returned into a compensated state after treatment. No side effects of tenofovir have been documented.
  
  
  CONCLUSIONS
  Tenofovir seems to be highly effective and safe in the prophylaxis and rescue treatment of HBV reactivation in patients who receive immunosuppression therapy.
authors.affiliation: Second Department of Internal Medicine, Medical School of Athens University, Hippokration General Hospital, Athens, Greece. Electronic address: koskinas@ath.forthnet.gr.
authors.forename: J S
authors.initials: JS
authors.lastname: Koskinas
authors.affiliation: Second Department of Internal Medicine, Medical School of Athens University, Hippokration General Hospital, Athens, Greece.
authors.forename: M
authors.initials: M
authors.lastname: Deutsch
authors.affiliation: Second Department of Internal Medicine, Medical School of Athens University, Hippokration General Hospital, Athens, Greece.
authors.forename: S
authors.initials: S
authors.lastname: Adamidi
authors.affiliation: Second Department of Internal Medicine, Medical School of Athens University, Hippokration General Hospital, Athens, Greece.
authors.forename: M
authors.initials: M
authors.lastname: Skondra
authors.affiliation: Second Department of Internal Medicine, Medical School of Athens University, Hippokration General Hospital, Athens, Greece.
authors.forename: M
authors.initials: M
authors.lastname: Tampaki
authors.affiliation: Second Department of Internal Medicine, Medical School of Athens University, Hippokration General Hospital, Athens, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Alexopoulou
authors.affiliation: Second Department of Internal Medicine, Medical School of Athens University, Hippokration General Hospital, Athens, Greece.
authors.forename: S
authors.initials: S
authors.lastname: Manolakopoulos
authors.affiliation: Second Department of Internal Medicine, Medical School of Athens University, Hippokration General Hospital, Athens, Greece.
authors.forename: D
authors.initials: D
authors.lastname: Pectasides
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D000368:Aged; D000369:Aged, 80 and over; D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control*; D006801:Humans; D016867:Immunocompromised Host; D007155:Immunologic Factors / Q000627:therapeutic use; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D063065:Organophosphonates / Q000494:pharmacology* / Q000627:therapeutic use*; D000069283:Rituximab; D000068698:Tenofovir; D014775:Virus Activation / Q000187:drug effects*
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D000998:Antiviral Agents; D007155:Immunologic Factors; D063065:Organophosphonates; D000069283:Rituximab; D000068698:Tenofovir; D000225:Adenine
keywords: HBV reactivation; Immunosuppression; Tenofovir