title: [Clinicopathological significance of gastric mucosal infection with coccoid Helicobacter pylori].
abstract: OBJECTIVE
  To study the detection method of coccoid helicobacter pylori (HP) and to investigate the significance of pure coccoid HP infection of gastric mucous membrane.
  
  
  METHODS
  A total of 171 gastric biopsy specimens were reviewed by HE stain, and the presence, density and tissue distribution of HP were investigated by sliver stain and immunohistochemistry(S-P method).
  
  
  RESULTS
  The rates of mucosal erosion and active inflammation with the presence of pure coccoid HP infection were 36.0% (9/25) and 44.0% (11/25), respectively, both higher than those without HP infection (13.5%, 10/74; 24.3%, 18/74), while lower than those infected with spiral HP (72.1%, 49/68; 79.4%, 54/68). The quantity of interstitial lymphocyte and inflammation severity were also higher than those without HP infection, while lower than those with spiral HP infection.
  
  
  CONCLUSIONS
  Pure coccoid HP causes human gastritis, similar to that of spiral HP infection but at a lesser degree. Further studies are important to confirm its clinical significance.
authors.affiliation: Department of Pathology, Rugao People's Hospital, Jiangsu Province, Rugao 226500, China. E-mail: rgryzdb793@sina.com.
authors.forename: Dongbing
authors.initials: D
authors.lastname: Zhu
authors.affiliation: Department of Pathology, Rugao People's Hospital, Jiangsu Province, Rugao 226500, China.
authors.forename: Li
authors.initials: L
authors.lastname: Sha
authors.affiliation: Department of Pathology, Rugao People's Hospital, Jiangsu Province, Rugao 226500, China.
authors.forename: Xiaojian
authors.initials: X
authors.lastname: Shen
authors.affiliation: Department of Pathology, Rugao People's Hospital, Jiangsu Province, Rugao 226500, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Huan
authors.affiliation: Department of Pathology, Rugao People's Hospital, Jiangsu Province, Rugao 226500, China.
authors.forename: Haiyun
authors.initials: H
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005756:Gastritis / Q000382:microbiology* / Q000473:pathology; D005757:Gastritis, Atrophic / Q000382:microbiology* / Q000473:pathology; D016481:Helicobacter Infections / Q000382:microbiology*; D016480:Helicobacter pylori / Q000145:classification / Q000302:isolation & purification; D006801:Humans; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged