title: High mobility group box 1 protein (HMGB-1): a pathogenic role in preeclampsia?
abstract: We evaluated whether preeclampsia is associated with elevated circulating levels of High mobility group box 1 protein (HMGB-1), a nuclear protein with proinflammatory effects when released extracellularly. We enrolled 48 women, 32 in third trimester pregnancy (16 with, 16 without preeclampsia), and 16 healthy non pregnant. In the peripheral blood of pregnant women, HMGB-1 concentration was assessed serially, before and after delivery. With or without preeclampsia, third trimester pregnancy was associated with elevated levels of HMGB-1. This elevation is exaggerated in preeclampsia. The source of HMGB-1 observed in these conditions is likely to involve tissues other than the placenta itself.
authors.affiliation: Division de Physiopathologie clinique, Centre hospitalier universitaire vaudois and University of Lausanne, Switzerland; Département de Gynécologie-obstétrique, Centre hospitalier universitaire vaudois and University of Lausanne, Switzerland.
authors.forename: P-A
authors.initials: PA
authors.lastname: Pradervand
authors.affiliation: Division de Physiopathologie clinique, Centre hospitalier universitaire vaudois and University of Lausanne, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Clerc
authors.affiliation: Division de Physiopathologie clinique, Centre hospitalier universitaire vaudois and University of Lausanne, Switzerland.
authors.forename: J
authors.initials: J
authors.lastname: Frantz
authors.affiliation: Division de Physiopathologie clinique, Centre hospitalier universitaire vaudois and University of Lausanne, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Rotaru
authors.affiliation: Laboratoire central de Chimie clinique, Centre hospitalier universitaire vaudois and University of Lausanne, Switzerland.
authors.forename: D
authors.initials: D
authors.lastname: Bardy
authors.affiliation: Division de Physiopathologie clinique, Centre hospitalier universitaire vaudois and University of Lausanne, Switzerland. Electronic address: Bernard.Waeber@chuv.ch.
authors.forename: B
authors.initials: B
authors.lastname: Waeber
authors.affiliation: Service de Médecine intensive adulte, Centre hospitalier universitaire vaudois and University of Lausanne, Switzerland.
authors.forename: L
authors.initials: L
authors.lastname: Liaudet
authors.affiliation: Département de Gynécologie-obstétrique, Centre hospitalier universitaire vaudois and University of Lausanne, Switzerland.
authors.forename: Y
authors.initials: Y
authors.lastname: Vial
authors.affiliation: Division de Physiopathologie clinique, Centre hospitalier universitaire vaudois and University of Lausanne, Switzerland.
authors.forename: F
authors.initials: F
authors.lastname: Feihl
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D024243:HMGB1 Protein / Q000097:blood*; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy
chemical_list: D024243:HMGB1 Protein; C585491:HMGB1 protein, human
keywords: High mobility group box-1 protein; Inflammation; Preeclampsia