title: Selenopeptide transamidation and metathesis.
abstract: Selenopeptides can be transamidated by cysteinyl peptides in water using mild conditions (pH 5.5, 37 °C) in the presence of an arylthiol catalyst. Similar conditions also catalyze the metathesis of selenopeptides. The usefulness of the selenophosphine derived from TCEP (TCEP═Se) for inhibiting the TCEP-induced deselenization of selenocysteine residue is also reported.
authors.affiliation: CNRS UMR 8161, Institut Pasteur de Lille, Université Lille Nord de France , 59021 Lille, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Ollivier
authors.forename: Annick
authors.initials: A
authors.lastname: Blanpain
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Boll
authors.forename: Laurent
authors.initials: L
authors.lastname: Raibaut
authors.forename: Hervé
authors.initials: H
authors.lastname: Drobecq
authors.forename: Oleg
authors.initials: O
authors.lastname: Melnyk
mesh_terms: D000595:Amino Acid Sequence; D002384:Catalysis; D015394:Molecular Structure; D016566:Organoselenium Compounds / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D017279:Selenocysteine / Q000737:chemistry; D014867:Water
chemical_list: D016566:Organoselenium Compounds; D010455:Peptides; D014867:Water; D017279:Selenocysteine