title: Steroidal sapogenins and glycosides from the fibrous roots of Polygonatum odoratum with inhibitory effect on tissue factor (TF) procoagulant activity.
abstract: Six new spirostane glycosides (1-6), named polygodosides A-F, one new furostanol glycoside, polygodoside G (7), one new cholestane glycoside, polygodoside H (8), and one new steroidal sapogenin, polygodosin A (9), together with thirteen known compounds (10-22) were isolated from a 90% MeOH extract of the fibrous roots of Polygonatum odoratum (Mill.) Druce. The structures of new compounds were elucidated by extensive 1D and 2D NMR spectroscopic analyses and mass spectrometry. The effects on TF procoagulant activity in THP-1 cells were tested for most of the compounds.
authors.affiliation: Department of Complex Prescription of Traditional Chinese Medicine, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, PR China; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Cai Lun Lu 1200, Shanghai 201203, PR China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Complex Prescription of Traditional Chinese Medicine, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, PR China.
authors.forename: Ling
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Complex Prescription of Traditional Chinese Medicine, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, PR China.
authors.forename: Jun-Ping
authors.initials: JP
authors.lastname: Kou
authors.affiliation: Department of Complex Prescription of Traditional Chinese Medicine, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, PR China.
authors.forename: Dan-Ni
authors.initials: DN
authors.lastname: Zhu
authors.affiliation: Department of Complex Prescription of Traditional Chinese Medicine, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, PR China. Electronic address: qijin2006@163.com.
authors.forename: Jin
authors.initials: J
authors.lastname: Qi
authors.affiliation: Department of Complex Prescription of Traditional Chinese Medicine, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, PR China. Electronic address: boyangyu59@163.com.
authors.forename: Bo-Yang
authors.initials: BY
authors.lastname: Yu
mesh_terms: D001778:Blood Coagulation Disorders / Q000188:drug therapy* / Q000378:metabolism; D002776:Cholestanes / Q000737:chemistry* / Q000302:isolation & purification; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D031384:Polygonatum / Q000737:chemistry; D012502:Sapogenins / Q000737:chemistry* / Q000302:isolation & purification; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification; D013261:Sterols / Q000737:chemistry* / Q000302:isolation & purification; D013925:Thromboplastin / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*
chemical_list: D002776:Cholestanes; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D012502:Sapogenins; D013256:Steroids; D013261:Sterols; C574436:furostanol glycoside; D013925:Thromboplastin
keywords: Polygonatum odoratum (Mill.) Druce; Steroidal sapogenins; Steroidal saponins; TF procoagulant activity