title: Rhodium-catalyzed direct synthesis of unprotected NH-sulfoximines from sulfoxides.
abstract: A novel rhodium-catalyzed imination of sulfoxides using O-(2,4-dinitrophenyl)hydroxylamine is developed under mild conditions with good functional group tolerance. This method provides an efficient access to free NH-sulfoximines, an important structural unit in a variety of biologically active compounds.
authors.affiliation: Department of Chemistry and Chemical Biology Indiana University Purdue University Indianapolis, Indianapolis, Indiana 46202, USA. ngrichar@iupui.edu geh@iupui.edu.
authors.forename: Jinmin
authors.initials: J
authors.lastname: Miao
authors.forename: Nigel G J
authors.initials: NG
authors.lastname: Richards
authors.forename: Haibo
authors.initials: H
authors.lastname: Ge
mesh_terms: D002384:Catalysis; D006898:Hydroxylamines / Q000138:chemical synthesis / Q000737:chemistry; D007097:Imines / Q000138:chemical synthesis* / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*; D013454:Sulfoxides / Q000138:chemical synthesis / Q000737:chemistry*; D013457:Sulfur Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D006898:Hydroxylamines; D007097:Imines; D013454:Sulfoxides; D013457:Sulfur Compounds; D012238:Rhodium; C050904:O-(2,4-dinitrophenyl)hydroxylamine