title: IOTA simple rules in differentiating between benign and malignant ovarian tumors.
abstract: BACKGROUND
  To evaluate the diagnostic performance of IOTA simple rules in differentiating between benign and malignant ovarian tumors.
  
  
  METHODS
  A study of diagnostic performance was conducted on women scheduled for elective surgery due to ovarian masses between March 2007 and March 2012. All patients underwent ultrasound examination for IOTA simple rules within 24 hours of surgery. All examinations were performed by the authors, who had no any clinical information of the patients, to differentiate between benign and malignant adnexal masses using IOTA simple rules. Gold standard diagnosis was based on pathological or operative findings.
  
  
  RESULTS
  A total of 398 adnexal masses, in 376 women, were available for analysis. Of them, the IOTA simple rules could be applied in 319 (80.1%) including 212 (66.5%) benign tumors and 107 (33.6%) malignant tumors. The simple rules yielded inconclusive results in 79 (19.9%) masses. In the 319 masses for which the IOTA simple rules could be applied, sensitivity was 82.9% and specificity 95.3%.
  
  
  CONCLUSIONS
  The IOTA simple rules have high diagnostic performance in differentiating between benign and malignant adnexal masses. Nevertheless, inconclusive results are relatively common.
authors.affiliation: Department of Obstetrics and Gynecology, Chiang Mai University, Thailand E-mail : ttongson@mail.med.cmu.ac.th.
authors.forename: Charuwan
authors.initials: C
authors.lastname: Tantipalakorn
authors.forename: Chanane
authors.initials: C
authors.lastname: Wanapirak
authors.forename: Surapan
authors.initials: S
authors.lastname: Khunamornpong
authors.forename: Kornkanok
authors.initials: K
authors.lastname: Sukpan
authors.forename: Theera
authors.initials: T
authors.lastname: Tongsong
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology*; D010053:Ovary / Q000473:pathology*; D012680:Sensitivity and Specificity; D055815:Young Adult