title: Impulse control disorders in frontotemporal dementia: spectrum of symptoms and response to treatment.
abstract: OBJECTIVE
  To describe a patient with behavioral variant frontotemporal dementia (bvFTD) presenting with impulse control disorders (ICDs) which responded to fluvoxamine and topiramate.
  
  
  METHODS
  A 64-year-old woman was affected by several ICDs. At disease onset, she suffered from impulsive smoking and overeating which caused a body weight increase of 20 kg in 6 months. Later on she manifested binge-eating behavior and skin-picking compulsion. Presence of progressive frontal cognitive impairment (Mini Mental State Examination 24/30) and evidence of hypoperfusion of the anterior cingulate and dorsolateral frontal cortex with brain single-photon emission computed tomography scan contributed to the diagnosis of bvFTD. Use of combination treatment with selective serotonin reuptake inhibitor drugs and topiramate improved all these symptoms.
  
  
  CONCLUSIONS
  This case extends the clinical phenotype of repetitive and compulsive habits in bvFTD to encompass symptoms suggestive of ICDs. It is proposed that fluvoxamine and topiramate may be considered as treatment options in these conditions.
authors.affiliation: Department of Neurosciences: Sciences NPSRR, University of Padova, Padova, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Pompanin
authors.affiliation: IRCCS San Camillo Hospital Foundation, Venice, Italy.
authors.forename: Nela
authors.initials: N
authors.lastname: Jelcic
authors.affiliation: Department of Medicine (DIMED), University of Padova, Padova, Italy.
authors.forename: Diego
authors.initials: D
authors.lastname: Cecchin
authors.affiliation: Department of Neurosciences: Sciences NPSRR, University of Padova, Padova, Italy; IRCCS San Camillo Hospital Foundation, Venice, Italy. Electronic address: annachiara.cagnin@unipd.it.
authors.forename: Annachiara
authors.initials: A
authors.lastname: Cagnin
mesh_terms: D000927:Anticonvulsants / Q000008:administration & dosage / Q000494:pharmacology*; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D004357:Drug Synergism; D005260:Female; D016666:Fluvoxamine / Q000008:administration & dosage / Q000494:pharmacology*; D057180:Frontotemporal Dementia / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D005632:Fructose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D008875:Middle Aged; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D000077236:Topiramate; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D016666:Fluvoxamine; D005632:Fructose; D017367:Selective Serotonin Reuptake Inhibitors; D000077236:Topiramate
keywords: Binge-eating disorder; Compulsion; Frontotemporal dementia; Impulse control disorder; Topiramate