title: PET/MRI radiotracer beyond ¹⁸F-FDG.
abstract: The recent development and introduction of new hybrid imaging devices combining positron emission tomography (PET) technology with magnetic resonance imaging (MRI) opens up new perspectives in clinical molecular imaging. Combining MRI and fluorine-18 choline PET would theoretically produce valuable clinical data in a single imaging session, which can be used for staging, prognosis, and assessment of treatment response. Fluorine-18-sodium fluoride (18F-NaF) is a highly sensitive PET tracer used as a marker of osteoblastic abnormalities. PET imaging with (68)Ga-DOTATATE or DOTATOC has demonstrated promising results for locating metastatic lesions, occasionally with superior sensitivity than whole-body MRI. l-DOPA PET adds data regarding l-DOPA metabolism, which may increase the specificity and sensibility of the study itself. Fluoromisonidazole is known to be not only a useful tracer for determining hypoxic cells but also an efficient hypoxic radiosensitizer.
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California, 505 Parnassus Avenue, M-396, San Francisco, CA 94143, USA. Electronic address: miguel.pampaloni@ucsf.edu.
authors.forename: Miguel Hernandez
authors.initials: MH
authors.lastname: Pampaloni
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California, 505 Parnassus Avenue, M-396, San Francisco, CA 94143, USA; Department of Radiology, Brescia, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Nardo
mesh_terms: D002250:Carbon Radioisotopes; D002794:Choline; D005462:Fluorine Radioisotopes; D006801:Humans; D007980:Levodopa; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008920:Misonidazole / Q000031:analogs & derivatives; D015282:Octreotide / Q000031:analogs & derivatives; D009942:Organometallic Compounds; D049268:Positron-Emission Tomography / Q000379:methods*; D011838:Radiation-Sensitizing Agents; D019275:Radiopharmaceuticals; D012969:Sodium Fluoride
chemical_list: D002250:Carbon Radioisotopes; D005462:Fluorine Radioisotopes; C499142:Ga(III)-DOTATOC; D009942:Organometallic Compounds; D011838:Radiation-Sensitizing Agents; D019275:Radiopharmaceuticals; C031843:fluoromisonidazole; D007980:Levodopa; D008920:Misonidazole; D012969:Sodium Fluoride; C513399:gallium Ga 68 dotatate; D002794:Choline; D015282:Octreotide
keywords: Imaging; MRI; PET; Radiotracers