title: Five-year follow-up of patients with type 1 diabetes transplanted with allogeneic islets: the UIC experience.
abstract: This report summarizes a 5-year phase 1/2 allogeneic islet transplantation clinical trial conducted at the University of Illinois at Chicago (UIC). Ten patients were enrolled in this single center, open label, and prospective trial in which patients received 1-3 transplants. The first four subjects underwent islet transplantation with the Edmonton immunosuppressive regimen and the remaining six subjects received the UIC immunosuppressive protocol (Edmonton plus etanercept and exenatide). All 10 patients achieved insulin independence after 1-3 transplants. At 5 years of follow-up, 6 of the initial 10 patients were free of exogenous insulin. During the follow-up period, 7 of the 10 patients maintained positive C-peptide levels and a composite hypoglycemic score of 0. Most patients maintained HbA1c levels <6.0 % (42.1 mmol/mol) and a significantly improved β-score. In conclusion, this study demonstrated long-term islet graft function without using T cell depleting induction, with an encouraging outcome that includes 60 % of patients remaining insulin independent after 5 years of initial transplantation.
authors.affiliation: Division of Transplantation, Department of Surgery, University of Illinois at Chicago, 840 South Wood Street CSB (Rm 402), Chicago, IL, 60612, USA.
authors.forename: Meirigeng
authors.initials: M
authors.lastname: Qi
authors.forename: Katie
authors.initials: K
authors.lastname: Kinzer
authors.forename: Kirstie K
authors.initials: KK
authors.lastname: Danielson
authors.forename: Joan
authors.initials: J
authors.lastname: Martellotto
authors.forename: Barbara
authors.initials: B
authors.lastname: Barbaro
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.forename: James T
authors.initials: JT
authors.lastname: Bui
authors.forename: Ron C
authors.initials: RC
authors.lastname: Gaba
authors.forename: Grace
authors.initials: G
authors.lastname: Knuttinen
authors.forename: Raquel
authors.initials: R
authors.lastname: Garcia-Roca
authors.forename: Ivo
authors.initials: I
authors.lastname: Tzvetanov
authors.forename: Andrew
authors.initials: A
authors.lastname: Heitman
authors.forename: Maureen
authors.initials: M
authors.lastname: Davis
authors.forename: James J
authors.initials: JJ
authors.lastname: McGarrigle
authors.forename: Enrico
authors.initials: E
authors.lastname: Benedetti
authors.forename: Jose
authors.initials: J
authors.lastname: Oberholzer
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000097:blood; D002641:Chicago; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000378:metabolism; D006785:Hospitals, University; D006801:Humans; D007328:Insulin / Q000097:blood; D016381:Islets of Langerhans Transplantation; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014184:Transplantation, Homologous
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D006442:Glycated Hemoglobin; D007328:Insulin; C517652:hemoglobin A1c protein, human