title: Midregional pro-adrenomedullin plasma concentrations are blunted in severe preeclampsia.
abstract: Levels of the peptide hormone adrenomedullin (AM) are elevated during normal pregnancy, but whether this differs during complications of pregnancy remains unresolved. AM can be quantified by measuring its pre-prohormone byproduct, midregional pro-adrenomedullin (MR-proADM). MR-proADM has shown prognostic value as a biomarker of heart failure, sepsis, and community-acquired pneumonia. Given the relevance of AM to pregnancy, we tested the hypothesis that MR-proADM provides a biomarker for preeclampsia. We find that MR-proADM plasma concentrations are blunted in severe preeclampsia and that MR-proADM is similarly effective as established biomarkers endoglin and placental growth factor at discriminating patients with severe preeclampsia from controls.
authors.affiliation: Departments of Cell Biology & Physiology, University of North Carolina at Chapel Hill, NC 27599, USA. Electronic address: brooke_matson@med.unc.edu.
authors.forename: B C
authors.initials: BC
authors.lastname: Matson
authors.affiliation: Departments of Genetics, University of North Carolina at Chapel Hill, NC 27599, USA. Electronic address: robert_corty@med.unc.edu.
authors.forename: R W
authors.initials: RW
authors.lastname: Corty
authors.affiliation: Departments of Cell Biology & Physiology, University of North Carolina at Chapel Hill, NC 27599, USA. Electronic address: karpinic@email.unc.edu.
authors.forename: N O
authors.initials: NO
authors.lastname: Karpinich
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address: murth002@mc.duke.edu.
authors.forename: A P
authors.initials: AP
authors.lastname: Murtha
authors.affiliation: Departments of Genetics, University of North Carolina at Chapel Hill, NC 27599, USA. Electronic address: william.valdar@unc.edu.
authors.forename: W
authors.initials: W
authors.lastname: Valdar
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address: chad.grotegut@duke.edu.
authors.forename: C A
authors.initials: CA
authors.lastname: Grotegut
authors.affiliation: Departments of Cell Biology & Physiology, University of North Carolina at Chapel Hill, NC 27599, USA; Departments of Genetics, University of North Carolina at Chapel Hill, NC 27599, USA. Electronic address: kathleen_caron@med.unc.edu.
authors.forename: K M
authors.initials: KM
authors.lastname: Caron
mesh_terms: D053607:Adrenomedullin / Q000097:blood*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011498:Protein Precursors / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D011498:Protein Precursors; C088633:proadrenomedullin; D053607:Adrenomedullin
keywords: Adrenomedullin; Midregional pro-adrenomedullin; Preeclampsia; Pregnancy