title: Baroreflex activation therapy for patients with drug-resistant hypertension.
abstract: Uncontrolled or resistant hypertension is still a major problem facing many physicians daily in the clinic. Several new therapies are being developed to help those patients whose blood pressure does not respond sufficiently to regular antihypertensive medication. One of these promising therapies is electrical activation of the carotid sinus baroreflex. In this overview, the authors predominantly summarize the background, efficacy and safety of this promising treatment with its latest achievements in patients with resistant hypertension. The authors also discuss certain issues that need further clarification before this therapy can be added to the common treatment guidelines of hypertension.
authors.affiliation: Maastricht University Medical Center, Department of Internal Medicine, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands.
authors.forename: Teba
authors.initials: T
authors.lastname: Alnima
authors.forename: Abraham A
authors.initials: AA
authors.lastname: Kroon
authors.forename: Peter W
authors.initials: PW
authors.lastname: de Leeuw
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use; D017704:Baroreflex; D002346:Carotid Sinus / Q000294:innervation; D015195:Drug Design; D004351:Drug Resistance; D004599:Electric Stimulation Therapy / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*
chemical_list: D000959:Antihypertensive Agents
keywords: baroreceptor; baroreflex activation therapy; resistant hypertension