title: The lncRNA PCAT29 inhibits oncogenic phenotypes in prostate cancer.
abstract: Long noncoding RNAs (lncRNA) have recently been associated with the development and progression of a variety of human cancers. However, to date, the interplay between known oncogenic or tumor-suppressive events and lncRNAs has not been well described. Here, the novel lncRNA, prostate cancer-associated transcript 29 (PCAT29), is characterized along with its relationship to the androgen receptor. PCAT29 is suppressed by DHT and upregulated upon castration therapy in a prostate cancer xenograft model. PCAT29 knockdown significantly increased proliferation and migration of prostate cancer cells, whereas PCAT29 overexpression conferred the opposite effect and suppressed growth and metastases of prostate tumors in chick chorioallantoic membrane assays. Finally, in prostate cancer patient specimens, low PCAT29 expression correlated with poor prognostic outcomes. Taken together, these data expose PCAT29 as an androgen-regulated tumor suppressor in prostate cancer.
  
  
  CONCLUSIONS
  This study identifies PCAT29 as the first androgen receptor-repressed lncRNA that functions as a tumor suppressor and that its loss may identify a subset of patients at higher risk for disease recurrence. Visual Overview: http://mcr.aacrjournals.org/content/early/2014/07/31/1541-7786.MCR-14-0257/F1.large.jpg.
authors.affiliation: Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan. Department of Pathology, University of Michigan, Ann Arbor, Michigan.
authors.forename: Rohit
authors.initials: R
authors.lastname: Malik
authors.affiliation: Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan. Department of Pathology, University of Michigan, Ann Arbor, Michigan.
authors.forename: Lalit
authors.initials: L
authors.lastname: Patel
authors.affiliation: Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan. Department of Pathology, University of Michigan, Ann Arbor, Michigan.
authors.forename: John R
authors.initials: JR
authors.lastname: Prensner
authors.affiliation: Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan. Department of Biostatistics, University of Michigan, Ann Arbor, Michigan.
authors.forename: Yang
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan. Department of Pathology, University of Michigan, Ann Arbor, Michigan.
authors.forename: Matthew K
authors.initials: MK
authors.lastname: Iyer
authors.affiliation: Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan.
authors.forename: Shruthi
authors.initials: S
authors.lastname: Subramaniyan
authors.affiliation: Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan.
authors.forename: Alexander
authors.initials: A
authors.lastname: Carley
authors.affiliation: Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan. Department of Pathology, University of Michigan, Ann Arbor, Michigan.
authors.forename: Yashar S
authors.initials: YS
authors.lastname: Niknafs
authors.affiliation: Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan. Department of Pathology, University of Michigan, Ann Arbor, Michigan.
authors.forename: Anirban
authors.initials: A
authors.lastname: Sahu
authors.affiliation: Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan. Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan.
authors.forename: Sumin
authors.initials: S
authors.lastname: Han
authors.affiliation: Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan. Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan.
authors.forename: Teng
authors.initials: T
authors.lastname: Ma
authors.affiliation: Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan.
authors.forename: Meilan
authors.initials: M
authors.lastname: Liu
authors.affiliation: Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan. Department of Pathology, University of Michigan, Ann Arbor, Michigan.
authors.forename: Irfan A
authors.initials: IA
authors.lastname: Asangani
authors.affiliation: Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan. Department of Pathology, University of Michigan, Ann Arbor, Michigan.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Jing
authors.affiliation: Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan. Department of Pathology, University of Michigan, Ann Arbor, Michigan.
authors.forename: Xuhong
authors.initials: X
authors.lastname: Cao
authors.affiliation: Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan. Department of Pathology, University of Michigan, Ann Arbor, Michigan.
authors.forename: Saravana M
authors.initials: SM
authors.lastname: Dhanasekaran
authors.affiliation: Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan. Department of Pathology, University of Michigan, Ann Arbor, Michigan.
authors.forename: Dan R
authors.initials: DR
authors.lastname: Robinson
authors.affiliation: Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan. Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan. Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan. arul@med.umich.edu ffeng@med.umich.edu.
authors.forename: Felix Y
authors.initials: FY
authors.lastname: Feng
authors.affiliation: Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan. Department of Pathology, University of Michigan, Ann Arbor, Michigan. Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan. Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan. arul@med.umich.edu ffeng@med.umich.edu.
authors.forename: Arul M
authors.initials: AM
authors.lastname: Chinnaiyan
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D016147:Genes, Tumor Suppressor; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D010641:Phenotype; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology; D062085:RNA, Long Noncoding / Q000235:genetics*; D025521:Tumor Suppressor Proteins / Q000235:genetics*
chemical_list: D062085:RNA, Long Noncoding; D025521:Tumor Suppressor Proteins