title: The replicometer is broken: telomeres activate cellular senescence in response to genotoxic stresses.
abstract: Telomeres, the ends of our linear chromosomes, can function as 'replicometers', capable of counting cell division cycles as they progressively erode with every round of DNA replication. Once they are critically short, telomeres become dysfunctional and consequently activate a proliferative arrest called replicative senescence. For many years, telomeres were thought to be autonomous structures, largely isolated from cell intrinsic and extrinsic signals, whose function is to prevent limitless cellular proliferation, a characteristic of most cancer cells. It is becoming increasingly evident, however, that telomeres not only count cell divisions, but also function as sensors of genotoxic stresses to stop cell cycle progression prematurely and long before cells would have entered replicative senescence. This stable growth arrest, triggered by dysfunctional telomeres that are not necessarily critically short, likely evolved as a tumor-suppressing mechanism as it prevents proliferation of cells that are at risk for acquiring potentially hazardous and transforming mutations both in vitro and in vivo. Here, we review studies supporting the concept that telomeres are important cellular structures whose function not only is to count cell divisions, but also to act as molecular switches that can rapidly stop cell cycle progression permanently in response to a variety of stresses, including oncogenic signals.
authors.affiliation: Department of Microbiology and Molecular Genetics, NJMS Cancer Center, Rm G1226 Rutgers Biomedical and Health Sciences, 205 South Orange Ave., Newark, NJ, 07103, USA.
authors.forename: Anitha
authors.initials: A
authors.lastname: Suram
authors.forename: Utz
authors.initials: U
authors.lastname: Herbig
mesh_terms: D000818:Animals; D016922:Cellular Senescence / Q000502:physiology*; D004249:DNA Damage / Q000502:physiology*; D006801:Humans; D019098:Telomerase / Q000235:genetics / Q000378:metabolism; D016615:Telomere / Q000235:genetics / Q000378:metabolism*
chemical_list: D019098:Telomerase
keywords: DNA damage; aging; cellular senescence; hTERT; p53; telomerase; telomere; tumor suppression