title: Scleroderma renal crisis following pericardial effusion in a Japanese female.
abstract: Scleroderma renal crisis (SRC) occurs in 4-5% of Japanese patients with systemic sclerosis (SSc) and is one of the most severe complications, along with interstitial pneumonia and pulmonary hypertension, which lead to a poor outcome. The factors predicting SRC include diffuse progressive skin thickening, a duration of SSc of 4 years or less, having autoantibodies against RNA polymerase III, systemic corticosteroid (CS) administration and recent cardiac events, including pericarditis. We herein report a female case of SRC preceded by pericardial effusion during the treatment with CS for rapidly progressive skin thickening. She had none of the known autoantibodies and was successfully treated with an angiotensin II receptor blocker.
authors.affiliation: Department of Dermatology, School of Medicine, Gifu University, Gifu City, Japan.
authors.forename: En
authors.initials: E
authors.lastname: Shu
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kanoh
authors.forename: Mariko
authors.initials: M
authors.lastname: Seishima
mesh_terms: D058186:Acute Kidney Injury / Q000188:drug therapy / Q000209:etiology*; D000328:Adult; D047228:Angiotensin II Type 1 Receptor Blockers / Q000627:therapeutic use; D005260:Female; D006801:Humans; D000068557:Olmesartan Medoxomil / Q000627:therapeutic use; D010490:Pericardial Effusion / Q000150:complications*; D045743:Scleroderma, Diffuse / Q000150:complications*
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D000068557:Olmesartan Medoxomil
keywords: angiotensin II receptor blocker; pericardial effusion; scleroderma renal crisis; systemic sclerosis; treatment