title: Identification of Helicobacter pylori infection in symptomatic patients in Surabaya, Indonesia, using five diagnostic tests.
abstract: SUMMARY The prevalence of Helicobacter pylori infection in Indonesia is controversial. We examined the H. pylori infection rate in 78 patients in a hospital in Surabaya using five different tests, including culture, histology, immunohistochemistry, rapid urease test, and urine antibody test. Furthermore, we analysed virulence factors in H. pylori strains from Indonesia. The H. pylori infection rate was only 11.5% in all patients studied, and 2.3% of Javanese patients and 18.0% of Chinese patients were infected (P = 0.01). Although severe gastritis was not observed, activity and inflammation were significantly higher in patients positive for H. pylori than in patients negative for H. pylori. Among genotypes identified from five isolated strains, cagA was found in four; two were vacA s1m1. All cagA-positive strains were oipA 'on' and iceA1 positive. We confirmed both a low H. pylori infection rate and a low prevalence of precancerous lesions in dyspeptic patients in a Surabaya hospital, which may contribute to the low incidence of gastric cancer in Indonesia.
authors.affiliation: Department of Environmental and Preventive Medicine,Oita University Faculty of Medicine,Yufu,Japan.
authors.forename: M
authors.initials: M
authors.lastname: Miftahussurur
authors.affiliation: Department of Environmental and Preventive Medicine,Oita University Faculty of Medicine,Yufu,Japan.
authors.forename: S
authors.initials: S
authors.lastname: Shiota
authors.affiliation: Department of Environmental and Preventive Medicine,Oita University Faculty of Medicine,Yufu,Japan.
authors.forename: R
authors.initials: R
authors.lastname: Suzuki
authors.affiliation: Department of Environmental and Preventive Medicine,Oita University Faculty of Medicine,Yufu,Japan.
authors.forename: M
authors.initials: M
authors.lastname: Matsuda
authors.affiliation: Department of Molecular Pathology,Oita University Faculty of Medicine,Yufu,Japan.
authors.forename: T
authors.initials: T
authors.lastname: Uchida
authors.affiliation: Department of Environmental and Preventive Medicine,Oita University Faculty of Medicine,Yufu,Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kido
authors.affiliation: Department of Environmental and Preventive Medicine,Oita University Faculty of Medicine,Yufu,Japan.
authors.forename: F
authors.initials: F
authors.lastname: Kawamoto
authors.affiliation: Gastroentero-Hepatology Division, Department of Internal Medicine,Airlangga University Faculty of Medicine,Surabaya,Indonesia.
authors.forename: U
authors.initials: U
authors.lastname: Maimunah
authors.affiliation: Gastroentero-Hepatology Division, Department of Internal Medicine,Airlangga University Faculty of Medicine,Surabaya,Indonesia.
authors.forename: P
authors.initials: P
authors.lastname: Adi
authors.affiliation: Institute of Tropical Disease, Airlangga University,Surabaya,Indonesia.
authors.forename: Y
authors.initials: Y
authors.lastname: Rezkitha
authors.affiliation: Institute of Tropical Disease, Airlangga University,Surabaya,Indonesia.
authors.lastname: Nasronudin
authors.affiliation: Gastroentero-Hepatology Division, Department of Internal Medicine,Airlangga University Faculty of Medicine,Surabaya,Indonesia.
authors.forename: I
authors.initials: I
authors.lastname: Nusi
authors.affiliation: Department of Environmental and Preventive Medicine,Oita University Faculty of Medicine,Yufu,Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Yamaoka
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood / Q000652:urine; D001944:Breath Tests; D046508:Culture Techniques; D004269:DNA, Bacterial / Q000032:analysis; D004415:Dyspepsia / Q000453:epidemiology / Q000382:microbiology*; D005260:Female; D005756:Gastritis / Q000382:microbiology / Q000473:pathology*; D005838:Genotype; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000453:epidemiology; D016480:Helicobacter pylori / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D007150:Immunohistochemistry; D007214:Indonesia / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D017422:Sequence Analysis, DNA; D013270:Stomach / Q000382:microbiology / Q000473:pathology*; D014508:Urea / Q000032:analysis; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial; D004269:DNA, Bacterial; D014508:Urea
keywords: virulence factors