title: On the origin of information in epigenetic structures in metazoans.
abstract: Epigenetic inheritance implies the existence of epigenetic information. Great progress has been made in recent years in understanding the role of the changes in epigenetic structures (methylated DNA, histone acetylation/deacetylation and chromatin remodelling) as well as the role of miRNA (MIR) expression patterns in epigenetic processes. However, as of yet, we do not have a satisfactory understanding of the origin of epigenetic information stored in, and conveyed by, these structures. We do not know whether these structures are the ultimate source of the information or whether they are simply media for storing and transmitting epigenetic information for gene expression from upstream sources to the phenotype. Herein an attempt is made to ascertain the ultimate sources of the epigenetic information they contain and transmit by tracing back the causal chain leading to the changes in epigenetic structures.
authors.affiliation: Department of Biology, University of Tirana, Tirana, Albania. Electronic address: nelson@epigeneticscomesofage.com.
authors.forename: Nelson R
authors.initials: NR
authors.lastname: Cabej
mesh_terms: D000107:Acetylation; D000818:Animals; D049109:Cell Proliferation; D002843:Chromatin / Q000378:metabolism; D042002:Chromatin Assembly and Disassembly; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D005260:Female; D006657:Histones / Q000378:metabolism; D006801:Humans; D008297:Male; D051379:Mice; D035683:MicroRNAs / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D010053:Ovary / Q000378:metabolism; D010641:Phenotype; D051381:Rats
chemical_list: D002843:Chromatin; D006657:Histones; D035683:MicroRNAs