title: New isocoumarins from a cold-adapted fungal strain mucor sp. and their developmental toxicity to zebrafish embryos.
abstract: Three new isocoumarin derivatives, mucorisocoumarins A-C (1-3, resp.), together with seven known compounds, 4-10, were isolated from the cold-adapted fungal strain Mucor sp. (No. XJ07027-5). The structures of the new compounds were identified by detailed IR, MS, and 1D- and 2D-NMR analyses. It was noteworthy that compounds 1, 2, 4, and 5 were successfully resolved by chiral HPLC, indicating that 1-7 should exist as enantiomers. In an embryonic developmental toxicity assay using a zebrafish model, compound 3 produced developmental abnormalities in the zebrafish embryos. This is the first report of isocoumarins with developmental toxicity to zebrafish embryos.
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, P. R. China, (phone/fax: +86-20-85221559).
authors.forename: Chun-Chi
authors.initials: CC
authors.lastname: Feng
authors.forename: Guo-Dong
authors.initials: GD
authors.lastname: Chen
authors.forename: Yan-Qiu
authors.initials: YQ
authors.lastname: Zhao
authors.forename: Sheng-Chang
authors.initials: SC
authors.lastname: Xin
authors.forename: Song
authors.initials: S
authors.lastname: Li
authors.forename: Jin-Shan
authors.initials: JS
authors.lastname: Tang
authors.forename: Xiao-Xia
authors.initials: XX
authors.lastname: Li
authors.forename: Dan
authors.initials: D
authors.lastname: Hu
authors.forename: Xing-Zhong
authors.initials: XZ
authors.lastname: Liu
authors.forename: Hao
authors.initials: H
authors.lastname: Gao
mesh_terms: D000064:Acclimatization; D000818:Animals; D003080:Cold Temperature; D004625:Embryo, Nonmammalian / Q000002:abnormalities* / Q000187:drug effects* / Q000196:embryology; D047108:Embryonic Development / Q000187:drug effects; D049934:Isocoumarins / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*; D009089:Mucor / Q000737:chemistry* / Q000502:physiology; D015027:Zebrafish / Q000196:embryology*
chemical_list: D049934:Isocoumarins
keywords: Fungi; Isocoumarins; Mucor; Toxicity; Zebrafish