title: First isolate of KPC-2-producing Klebsiella pneumonaie sequence type 23 from the Americas.
abstract: KPC-2-producing Klebsiella pneumoniae isolates mainly correspond to clonal complex 258 (CC258); however, we describe KPC-2-producing K. pneumoniae isolates belonging to invasive sequence type 23 (ST23). KPC-2 has scarcely been reported to occur in ST23, and this report describes the first isolation of this pathogen in the Americas. Acquisition of resistant markers in virulent clones could mark an evolutionary step toward the establishment of these clones as major nosocomial pathogens.
authors.affiliation: Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Daniela
authors.initials: D
authors.lastname: Cejas
authors.affiliation: Hospital Alemán, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Liliana
authors.initials: L
authors.lastname: Fernández Canigia
authors.affiliation: Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina Escuela de Bacteriología, Universidad Industrial de Santander, Bucaramanga, Colombia.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Rincón Cruz
authors.affiliation: Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Alan X
authors.initials: AX
authors.lastname: Elena
authors.affiliation: Hospital Alemán, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Ivana
authors.initials: I
authors.lastname: Maldonado
authors.affiliation: Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Gabriel O
authors.initials: GO
authors.lastname: Gutkind
authors.affiliation: Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina marcelaradice@gmail.com.ar.
authors.forename: Marcela A
authors.initials: MA
authors.lastname: Radice
mesh_terms: D000369:Aged, 80 and over; D000569:Americas; D001431:Bacteriological Techniques; D019143:Evolution, Molecular; D023061:Gene Order; D005798:Genes, Bacterial; D005838:Genotype; D006801:Humans; D007710:Klebsiella Infections / Q000175:diagnosis* / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D008297:Male; D058889:Molecular Typing; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
chemical_list: D001618:beta-Lactamases; C547585:beta-lactamase KPC-2, Klebsiella pneumoniae