title: Dissection of signaling in inflammation: three novel inflammatory regulators.
abstract: Uncontrolled inflammation is a feature of autoimmune diseases and autoinflammatory syndromes and may promote tumorigenesis. Thus, identifying molecules that regulate the signaling pathways triggering, mediating, and suppressing inflammation could be helpful in developing new therapeutic approaches for these debilitating diseases. In this review, we present new information on three molecules with important roles in controlling inflammation: MALT1, Ariadne-2, and acetylcholine. We summarize our current state of knowledge of how these molecules function, and how they are involved in pathways of NF-κB activation or vagal nerve stimulation associated with inflammation.
authors.affiliation: The Campbell Family Institute for Breast Cancer Research and Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C1, Canada.
authors.forename: Thorsten
authors.initials: T
authors.lastname: Berger
authors.affiliation: The Campbell Family Institute for Breast Cancer Research and Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C1, Canada.
authors.forename: Mary E
authors.initials: ME
authors.lastname: Saunders
authors.affiliation: The Campbell Family Institute for Breast Cancer Research and Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C1, Canada tmak@uhnres.utoronto.ca.
authors.forename: Tak W
authors.initials: TW
authors.lastname: Mak
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry; D001327:Autoimmune Diseases / Q000378:metabolism; D020169:Caspases / Q000378:metabolism; D003198:Computer Simulation; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation; D051379:Mice; D000074884:Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein; D016328:NF-kappa B / Q000378:metabolism; D009363:Neoplasm Proteins / Q000378:metabolism; D010766:Phosphorylation; D015398:Signal Transduction; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D016328:NF-kappa B; D009363:Neoplasm Proteins; C506696:ARIH2 protein, human; D044767:Ubiquitin-Protein Ligases; D020169:Caspases; C400109:MALT1 protein, human; D000074884:Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein; D000109:Acetylcholine