title: Structural DNA nanotechnology: state of the art and future perspective.
abstract: Over the past three decades DNA has emerged as an exceptional molecular building block for nanoconstruction due to its predictable conformation and programmable intra- and intermolecular Watson-Crick base-pairing interactions. A variety of convenient design rules and reliable assembly methods have been developed to engineer DNA nanostructures of increasing complexity. The ability to create designer DNA architectures with accurate spatial control has allowed researchers to explore novel applications in many directions, such as directed material assembly, structural biology, biocatalysis, DNA computing, nanorobotics, disease diagnosis, and drug delivery. This Perspective discusses the state of the art in the field of structural DNA nanotechnology and presents some of the challenges and opportunities that exist in DNA-based molecular design and programming.
authors.affiliation: Center for Molecular Design and Biomimicry, Biodesign Institute, and ‡Department of Chemistry and Biochemistry, Arizona State University , Tempe, Arizona 85287, United States.
authors.forename: Fei
authors.initials: F
authors.lastname: Zhang
authors.forename: Jeanette
authors.initials: J
authors.lastname: Nangreave
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Hao
authors.initials: H
authors.lastname: Yan
mesh_terms: D000465:Algorithms; D004247:DNA / Q000737:chemistry*; D016503:Drug Delivery Systems; D006801:Humans; D018625:Microscopy, Atomic Force; D062346:Molecular Medicine / Q000379:methods; D049329:Nanostructures / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods*; D009690:Nucleic Acid Conformation; D011506:Proteins / Q000737:chemistry; D012313:RNA / Q000737:chemistry; D012371:Robotics
chemical_list: D011506:Proteins; D012313:RNA; D004247:DNA