title: The biocatalytic repertoire of natural biaryl formation.
abstract: The catalytic and selective construction of carbon-carbon bonds for the generation of complex molecules is one of the most important tasks in organic chemistry. This was clearly highlighted by the 2010 Nobel Prize in Chemistry, which was awarded for the development of Pd-catalyzed cross-coupling reactions. The underlying concept of cross-linking building blocks to generate molecular complexity can also be widely found in natural product biosynthesis. Impressive examples for such natural cross-coupling reactions are biosynthetic processes for the assembly of biaryl moieties in natural products--highly efficient enzymatic reactions that often achieve synthetically yet unmatched selectivities. This Minireview highlights selected examples that showcase these fascinating biotransformations.
authors.affiliation: Biosystems Chemistry, Department of Chemistry and Center of Integrated Protein Science Munich, Technische Universität München, Lichtenbergstrasse 4, 85748 Garching (Germany) http://www.biosystemchemie.ch.tum.de.
authors.forename: Hülya
authors.initials: H
authors.lastname: Aldemir
authors.forename: René
authors.initials: R
authors.lastname: Richarz
authors.forename: Tobias A M
authors.initials: TA
authors.lastname: Gulder
mesh_terms: D055162:Biocatalysis; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry*; D002625:Chemistry, Organic; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D001688:Biological Products
keywords: biaryls; biosynthesis; enzymes; natural products; oxidative coupling