title: (1)H-MRS is useful to reinforce the suspicion of primary central nervous system lymphoma prior to surgery.
abstract: OBJECTIVE
  To assess whether (1)H-MRS may be useful to reinforce the radiological suspicion of PCNSL.
  
  
  METHODS
  In this retrospective study, we included 546 patients with untreated brain tumours in which single-voxel spectroscopy at TE 30 ms and 136 ms had been performed. The patients were split into two subgroups: "training set" and "test set." Differences between PCNSL and five other types of intracranial tumours were assessed in the test set of patients using the Mann-Whitney U nonparametric test and cut-off values for pair-wise comparisons defined by constructing receiver operating characteristic curves. These thresholds were used to construct classifiers for binary comparison between PCNSL and non-PCNSL. The performance of the obtained classifiers was assessed in the independent test set of patients.
  
  
  RESULTS
  Significant differences were found between PCNSL and the other groups evaluated. All bilateral comparisons performed in the test set obtained accuracy values above 70 % (71-89 %). Lipids were found to be useful to discriminate between PCNSL and glioblastoma/metastasis at short TE. Myo-inositol resonance was found to be very consistent for discriminating between PCNSL and astrocytomas at short TE.
  
  
  CONCLUSIONS
  (1)H-MRS is useful to reinforce diagnostic suspicion of PCNSL on MRI.
  
  
  CONCLUSIONS
  • (1) H-MRS can be used to reinforce the diagnostic suspicion of PCNSL. • Lipids can be used to discriminate between PCNSL and GB/MET. • Myo-inositol resonance can be used to discriminate between PCNSL and astrocytomas.
authors.affiliation: Department of Radiology, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain, palomamora@bellvitgehospital.cat.
authors.forename: Paloma
authors.initials: P
authors.lastname: Mora
authors.forename: Carles
authors.initials: C
authors.lastname: Majós
authors.forename: Sara
authors.initials: S
authors.lastname: Castañer
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Sánchez
authors.forename: Andreu
authors.initials: A
authors.lastname: Gabarrós
authors.forename: Amadeo
authors.initials: A
authors.lastname: Muntané
authors.forename: Carles
authors.initials: C
authors.lastname: Aguilera
authors.forename: Carles
authors.initials: C
authors.lastname: Arús
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016543:Central Nervous System Neoplasms / Q000175:diagnosis* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis* / Q000601:surgery; D008279:Magnetic Resonance Imaging / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D057234:Preoperative Period; D012372:ROC Curve; D015203:Reproducibility of Results; D012189:Retrospective Studies; D055815:Young Adult