title: Chromatin: a capacitor of acetate for integrated regulation of gene expression and cell physiology.
abstract: Cancer tissues with lower global levels of histone acetylation display significantly increased rate of tumor recurrence or cancer-related mortality. The function global regulation of histone acetylation serves for the cell or how lower levels of histone acetylation may contribute to a more aggressive cancer phenotype has been unclear. Chromatin and histone modifications are currently thought to regulate only DNA-based processes. However, recent findings have revealed a novel function for global histone acetylation in direct regulation of cellular physiology. I will discuss how chromatin, by regulating the cellular flux of acetate, may integrate control of cellular physiologic state with gene expression and help explain the observations in cancer tissues.
authors.affiliation: Department of Biological Chemistry, Molecular Biology Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. Electronic address: skurdistani@mednet.ucla.edu.
authors.forename: Siavash K
authors.initials: SK
authors.lastname: Kurdistani
mesh_terms: D000085:Acetates / Q000378:metabolism*; D000107:Acetylation; D000818:Animals; D002468:Cell Physiological Phenomena; D002843:Chromatin / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D006657:Histones / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008954:Models, Biological
chemical_list: D000085:Acetates; D002843:Chromatin; D006657:Histones