title: A common haplotype of KIAA0319 contributes to the phonological awareness skill in Chinese children.
abstract: BACKGROUND
  Previous studies have shown that KIAA0319 is a candidate gene for dyslexia in western populations. In view of the different languages used in Caucasian and Chinese populations, the aim of the present study was to investigate whether there is also an association of KIAA0319 in Chinese children with dyslexia and/or to the language-related cognitive skills.
  
  
  RESULTS
  A total of twenty six single nucleotide polymorphisms (SNPs) were genotyped from three hundred and ninety three individuals from 131 Chinese families. Four of the SNPs have been reported in the literature and twenty two being tag SNPs at KIAA0319. Analysis for allelic and haplotypic associations was performed with the UNPHASED program and multiple testing was corrected using permutation. Results indicate that KIAA0319 is not associated with Chinese children with dyslexia but a haplotype consisting of rs2760157 and rs807507 SNPs were significantly associated with an onset detection test, a measure of phonological awareness (pnominal = 6.85 10-5 and pcorrected = 0.0029).
  
  
  CONCLUSIONS
  In conclusion, our findings suggest that KIAA0319 is associated with a reading-related cognitive skill.
authors.forename: Cadmon King-Poo
authors.initials: CK
authors.lastname: Lim
authors.forename: Amabel May-Bo
authors.initials: AM
authors.lastname: Wong
authors.forename: Connie Suk-Han
authors.initials: CS
authors.lastname: Ho
authors.affiliation: Croucher Laboratory for Human Genomics, School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong. mary-waye@cuhk.edu.hk.
authors.forename: Mary Mui-Yee
authors.initials: MM
authors.lastname: Waye
mesh_terms: D000293:Adolescent; D044466:Asian People; D001364:Awareness / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D004410:Dyslexia / Q000235:genetics / Q000523:psychology; D005260:Female; D006239:Haplotypes; D006801:Humans; D007802:Language; D008297:Male; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000502:physiology*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011932:Reading
chemical_list: C500377:KIAA0319 protein, human; D009419:Nerve Tissue Proteins