title: Renal function, nephrogenic systemic fibrosis and other adverse reactions associated with gadolinium-based contrast media.
abstract: Nephrogenic systemic fibrosis is a fibrosing disorder that affects patients with impaired renal function and is associated with the administration of gadolinium-based contrast media used in MRI. Despite being in a group of drugs that were considered safe, report about this potentially serious adverse reaction was a turning point in the administration guidelines of these contrast media. There has been an attempt to establish safety parameters to identify patients with risk factors of renal failure. The close pharmacovigilance and strict observation of current regulations, with special attention being paid to the value of glomerular filtration, have reduced the published cases involving the use of gadolinium-based contrast media. In a meeting between radiologists and nephrologists we reviewed the most relevant aspects currently and recommendations for its prevention.
authors.forename: Ana
authors.initials: A
authors.lastname: Canga
authors.forename: Maria
authors.initials: M
authors.lastname: Kislikova
authors.forename: María
authors.initials: M
authors.lastname: Martínez-Gálvez
authors.forename: Mercedes
authors.initials: M
authors.lastname: Arias
authors.forename: Patricia
authors.initials: P
authors.lastname: Fraga-Rivas
authors.forename: Cecilio
authors.initials: C
authors.lastname: Poyatos
authors.forename: Angel L M
authors.initials: AL
authors.lastname: de Francisco
mesh_terms: D002985:Clinical Protocols; D003287:Contrast Media / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D005682:Gadolinium / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology*; D054989:Nephrogenic Fibrosing Dermopathy / Q000139:chemically induced* / Q000628:therapy
chemical_list: D003287:Contrast Media; D005682:Gadolinium