title: Bioactive metabolites produced by the endophytic fungus Phomopsis sp. YM355364.
abstract: A new compound, 16-acetoxycytosporone B (1), along with four known ones, dankasterone A (2), dankasterone B (3), 3beta,5alpha,9alpha-trihydroxy-(22E,24R)-ergosta-7,22-dien-6-one (4), and cyclonerodiol oxide (5), were isolated from Phomopsis sp. YM355364, an endophytic fungus of Aconitum carmichaeli. Their structures were characterized by spectral analysis. Compound 2 exhibited significant inhibitory activity against influenza A/Thailand/Kan353/2004(H5N1) pseudovirus with all IC50 value of 3.56 microM. Compounds 1, 2, and 4 showed either moderate or weak antifungal activities against four pathogenic fungi.
authors.forename: Kai-Xia
authors.initials: KX
authors.lastname: Ma
authors.forename: Xin-Tian
authors.initials: XT
authors.lastname: Shen
authors.forename: Rong
authors.initials: R
authors.lastname: Huang
authors.forename: Tang
authors.initials: T
authors.lastname: Wang
authors.forename: Xiao-Song
authors.initials: XS
authors.lastname: Xie
authors.forename: Shu-Wen
authors.initials: SW
authors.lastname: Liu
authors.forename: Shao-Hua
authors.initials: SH
authors.lastname: Wu
authors.forename: Jian
authors.initials: J
authors.lastname: Heb
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000378:metabolism*; D060026:Endophytes / Q000378:metabolism
chemical_list: D000935:Antifungal Agents