title: Increased serum leptin and resistin levels and increased carotid intima-media wall thickness in patients with psoriasis: is psoriasis associated with atherosclerosis?
abstract: BACKGROUND
  Patients with psoriasis may have an increased risk of cardiovascular disease.
  
  
  OBJECTIVE
  We sought to evaluate the potential association between subclinical atherosclerosis and psoriasis by measuring the intima-media wall thickness (IMT) of the common carotid artery (CCA) in patients with psoriasis and evaluating its correlation with serum leptin and resistin levels.
  
  
  METHODS
  The mean IMT (MIMT) of the CCA and leptin, resistin, triglyceride (TG), and total cholesterol levels in serum were determined in 60 patients and 60 healthy sex- and age-matched control subjects.
  
  
  RESULTS
  Compared with the healthy control subjects, patients with psoriasis had significantly higher MIMT of the CCA and higher levels of serum leptin, resistin, TG, and total cholesterol. In addition, MIMT of the CCA was positively correlated with serum leptin, resistin, TG, and total cholesterol levels in patients with psoriasis.
  
  
  CONCLUSIONS
  This was a cross-sectional single-center study, and we could not evaluate additional biomarkers such as adipokine or adiponectin because of our restricted facilities.
  
  
  CONCLUSIONS
  Although serum leptin, resistin, TG, and total cholesterol levels and MIMT of the CCA were significantly increased in patients with psoriasis, MIMT of the CCA was also positively correlated with these biomarkers. Therefore, psoriasis could be an independent risk factor for subclinical atherosclerosis.
authors.affiliation: Skin Research Center, Department of Dermatology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: rezarobati@sbmu.ac.ir.
authors.forename: Reza M
authors.initials: RM
authors.lastname: Robati
authors.affiliation: Skin Research Center, Department of Dermatology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Partovi-Kia
authors.affiliation: Department of Radiology, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Hamid Reza
authors.initials: HR
authors.lastname: Haghighatkhah
authors.affiliation: Skin Research Center, Department of Dermatology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Shima
authors.initials: S
authors.lastname: Younespour
authors.affiliation: Skin Research Center, Department of Dermatology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Fahimeh
authors.initials: F
authors.lastname: Abdollahimajd
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000453:epidemiology* / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D059168:Carotid Intima-Media Thickness / Q000009:adverse effects*; D016893:Carotid Stenosis / Q000453:epidemiology* / Q000503:physiopathology; D016022:Case-Control Studies; D015897:Comorbidity; D005260:Female; D006801:Humans; D015994:Incidence; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011565:Psoriasis / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D052243:Resistin / Q000097:blood*; D018570:Risk Assessment; D012720:Severity of Illness Index; D017678:Sex Distribution; D018709:Statistics, Nonparametric; D055815:Young Adult
chemical_list: D015415:Biomarkers; D020738:Leptin; D052243:Resistin
keywords: common carotid artery wall thickness; leptin; psoriasis; resistin; subclinical atherosclerosis; ultrasound