title: Intracellular lipid accumulation and shift during diabetes progression.
abstract: In past decades, type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease developed into a global public health disease with an endemic scale. Although up to now the pathogenesis of T2DM is still poorly understood, ectopic lipid accumulation is one of the strongest predictors for T2DM and is closely associated with insulin resistance.This review aims (i) to overview recent literature on the impact of intracellular lipid deposition, (ii) to point out changes in ectopic fat accumulation during diabetes progression or shortly after initializing individual therapy, and finally (iii) to expose unsolved questions and future perspectives in the role of ectopic lipids for the development of insulin resistance and T2DM.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
authors.forename: Peter
authors.initials: P
authors.lastname: Wolf
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Winhofer
authors.forename: Christian-Heinz
authors.initials: CH
authors.lastname: Anderwald
authors.forename: Martin
authors.initials: M
authors.lastname: Krššák
authors.forename: Michael
authors.initials: M
authors.lastname: Krebs
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D015897:Comorbidity; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy; D058065:Diabetic Cardiomyopathies / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D018450:Disease Progression; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D065626:Non-alcoholic Fatty Liver Disease / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy
chemical_list: D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified