title: Bioadhesive okra polymer based buccal patches as platform for controlled drug delivery.
abstract: In the present investigation, polysaccharide from the Okra fruits (Hibiscus esculentus) was extracted, characterized and explored for its mucoadhesive potential. Mucoadhesive films of okra polymer (OP) were prepared by solvent casting method based on 3(2) factorial design. For these studies, OP (2.0%, 2.5%, 3.0%, w/v) and glycerol (plasticizer) (0.25%, 0.50%, 0.75%, v/v) were taken as independent variables while tensile strength, mucoadhesive strength, contact angle, swelling index and residence time as dependent variables. The developed films were evaluated for their physicochemical, mechanical and electrical properties. The formulated films were found to be smooth, flexible, and displayed adequate mucoadhesive and tensile strength. Their near neutral pH and negative hemolytic studies indicated their non-irritability and biocompatible nature with biological tissues. The formulation comprising of 3% OP and 0.5% glycerol (F8) was found to exhibit optimum mechanical properties. Further, optimized film was loaded with zolmitriptan (model drug) to determine its drug release profiles. In vitro and ex vivo drug release studies demonstrated a controlled release of zolmitriptan over a period of 8h in simulated salivary fluid (SSF) pH 6.8, with the correlation coefficient values indicating its non-Fickian kinetics. Thus, OP can be used as a promising biomaterial for controlled drug delivery.
authors.affiliation: Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, Punjab, India. Electronic address: kaurgpt@gmail.com.
authors.forename: Gurpreet
authors.initials: G
authors.lastname: Kaur
authors.affiliation: Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, Punjab, India.
authors.forename: Deepinder
authors.initials: D
authors.lastname: Singh
authors.affiliation: Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, Punjab, India.
authors.forename: Vivekjot
authors.initials: V
authors.lastname: Brar
mesh_terms: D028483:Abelmoschus / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D065546:Drug Liberation; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D055595:Mechanical Phenomena; D009061:Mouth Mucosa; D064209:Phytochemicals / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D012212:Rheology; D012995:Solubility
chemical_list: D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D064209:Phytochemicals; D011108:Polymers
keywords: Drug release studies; Mucoadhesion; Okra polymer