title: Optic neuritis following Varicella zoster vaccination: report of two cases.
abstract: Two women presented at our clinic with vision blurring following Varicella zoster virus (VZV) vaccination, 3 weeks and 1 week ago. Ophthalmologic examination and magnetic resonance imaging revealed bilateral and unilateral optic neuritis, respectively. One patient had a history of optic neuritis in the fellow eye 33 years ago without recurrence since then. Both patients completely recovered after treatment with high dose intravenous methylprednisolone followed by a tapered dose of oral prednisolone. This is the first report of optic neuritis occurring in relation to VZV vaccination.
authors.affiliation: Department of Ophthalmology, Kangwon National University Hospital, Kangwon National University Graduate School of Medicine, Chuncheon, South Korea.
authors.forename: Sang Beom
authors.initials: SB
authors.lastname: Han
authors.affiliation: Department of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Jeong-Min
authors.initials: JM
authors.lastname: Hwang
authors.affiliation: Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Ji-Soo
authors.initials: JS
authors.lastname: Kim
authors.affiliation: Department of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, South Korea. Electronic address: eye@snubh.org.
authors.forename: Hee Kyung
authors.initials: HK
authors.lastname: Yang
mesh_terms: D000328:Adult; D019433:Chickenpox Vaccine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D009902:Optic Neuritis / Q000139:chemically induced* / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use; D014611:Vaccination / Q000009:adverse effects*
chemical_list: D019433:Chickenpox Vaccine; D011239:Prednisolone; D008775:Methylprednisolone
keywords: Optic neuritis; Varicella zoster virus vaccination