title: Acute fluctuation in blood glucose has no effect on platelet aggregation rate.
abstract: BACKGROUND
  Short-term acute blood glucose fluctuations are often found among patients with high risk of thrombosis. Influence of the phenomenon on platelet aggregation rate is of clinical importance and should be clearly evaluated.
  
  
  METHODS
  We measured ADP and arachidonic acid-induced platelet aggregation on 58 patients with type II diabetes or acute coronary syndrome before and after oral intake of 75 g of glucose. C-peptide and insulin levels were measured in diabetic patients and glycated hemoglobin was determined in ACS patients.
  
  
  RESULTS
  Results showed that short-term acute glucose fluctuation had no significant impact on platelet aggregation in these patients. In diabetes patients, the 2 hours platelet aggregation rate induced by ADP was positively correlated with insulin levels (r = 0.477, p = 0.014). AA-induced platelet aggregation was positively correlated with BMI (r = 0.619, p = 0.024). In ACS cases, there was no correlation between platelet aggregation rates and glycated hemoglobin.
  
  
  CONCLUSIONS
  There is probably no need to consider the possible influence of acute blood glucose fluctuation on thrombotic events.
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Gu
authors.forename: Liqiang
authors.initials: L
authors.lastname: Chen
authors.forename: Mian
authors.initials: M
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Cui
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000503:physiopathology; D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D000368:Aged; D016718:Arachidonic Acid / Q000494:pharmacology; D001786:Blood Glucose / Q000502:physiology*; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects / Q000502:physiology*; D010979:Platelet Function Tests
chemical_list: D001786:Blood Glucose; D016718:Arachidonic Acid; D000244:Adenosine Diphosphate