title: Observational study of axilla treatment for breast cancer patients with 1-3 positive micrometastases or macrometastases in sentinel lymph nodes.
abstract: Sentinel node biopsy is a standard procedure in clinically node-negative breast cancer patients. It has eliminated unnecessary axillary lymph node dissection in more than half of the early breast cancers. However, one of the unresolved issues in sentinel node biopsy is how to manage axilla surgery for sentinel node-positive patients and clinically node-negative patients. To evaluate the outcome of no axillary lymph node dissection in sentinel node-positive breast cancer, a prospective cohort study registering early breast cancer patients with positive sentinel nodes has been conducted (UMIN 000011782). Patients with 1-3 positive micrometastases or macrometastases in sentinel lymph nodes are eligible for the study. The primary endpoint is the recurrence rate of regional lymph nodes in patients treated with sentinel node biopsy. Patients treated with sentinel node biopsy followed by axillary lymph node dissection are also registered simultaneously to compare the prognosis. The propensity score matching is used to make the distributions of baseline risk factors comparable.
authors.affiliation: Department of Biostatistics and Epidemiology, Yokohama City University, Yokohama mari@yokohama-cu.ac.jp.
authors.forename: Mari S
authors.initials: MS
authors.lastname: Oba
authors.affiliation: Department of Breast Surgery, School of Medicine Kyorin University, Tokyo.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Imoto
authors.affiliation: Department of Surgery, University of Kurume Faculty of Medicine, Kurume.
authors.forename: Uhi
authors.initials: U
authors.lastname: Toh
authors.affiliation: Department of Breast Surgery, National Cancer Center Hospital East, Chiba.
authors.forename: Noriaki
authors.initials: N
authors.lastname: Wada
authors.affiliation: General Thoracic Surgery, Breast Surgery, Sapporo Medical Center, Tonan Hospital, Sapporo.
authors.forename: Masaya
authors.initials: M
authors.lastname: Kawada
authors.affiliation: Department of Surgery, Asahikawa Medical University, Asahikawa.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kitada
authors.affiliation: Department of Surgery, Breast Oncology, National Hospital Organization, Osaka National Hospital, Osaka.
authors.forename: Norikazu
authors.initials: N
authors.lastname: Masuda
authors.affiliation: Department of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine, Kyoto.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Taguchi
authors.affiliation: Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Minami
authors.affiliation: Department of Surgery, Keio University School of Medicine, Tokyo.
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Jinno
authors.affiliation: Tokai Central Hospital, Gifu.
authors.forename: Junichi
authors.initials: J
authors.lastname: Sakamoto
authors.affiliation: Department of Biomedical Statistics and Bioinformatics, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Morita
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008875:Middle Aged; D001365:Axilla; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery; D053208:Kaplan-Meier Estimate; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology / Q000601:surgery; D008207:Lymphatic Metastasis / Q000175:diagnosis; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D011446:Prospective Studies; D021701:Sentinel Lymph Node Biopsy; D016896:Treatment Outcome
keywords: breast cancer; lymph node dissection; propensity score; sentinel node biopsy