title: Mean platelet volume and red cell distribution width as a diagnostic marker in acute appendicitis.
abstract: BACKGROUND
  Acute appendicitis (AA) is one of the most common causes of emergent surgeries. Many methods are used for its diagnosis.
  
  
  OBJECTIVE
  This study was conducted to investigate the diagnostic value of MPV and RDW in acute appendicitis.
  
  
  METHODS
  This study was a retrospective multi-center cross sectional planned study. The study included 260 patients operated for AA and 158 patients as the control group. Groups were compared in terms of MPV, RDW, white blood cell count (WBC), neutrophil predominance (NP) and platelet count (PC).
  
  
  RESULTS
  MPV was significantly lower in AA group, compared to the control group (P < 0.001). The best cut-off level for MVP in AA was ≤ 7.3 fL and the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and overall accuracy ratio were 45%, 89.2%, 87.3%, 49.6% and 61.7%, respectively. There was no significant difference between the two groups in terms of RDW and platelet values.
  
  
  CONCLUSIONS
  MPV is a routinely measured parameter in complete blood count (CBC) and requires no additional cost. It significantly decreased in AA, having a greater sensitivity and NPV when combined with WBC and NP.
authors.affiliation: Department of Emergency Medicine, Ministry of Health, Erzurum Area Training and Research Hospital, Erzurum, Turkey.
authors.forename: Ceren Sen
authors.initials: CS
authors.lastname: Tanrikulu
authors.affiliation: Department of General Surgery, Ministry of Health, Erzurum Area Training and Research Hospital, Erzurum, Turkey.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Tanrikulu
authors.affiliation: Department of General Surgery, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey.
authors.forename: Mehmet Zafer
authors.initials: MZ
authors.lastname: Sabuncuoglu
authors.affiliation: Department of Emergency Medicine, Faculty of Medicine, Gazi University, Ankara, Turkey.
authors.forename: Mehmet Akif
authors.initials: MA
authors.lastname: Karamercan
authors.affiliation: Department of General Surgery, Ministry of Health, Mus State Hospital, Mus, Turkey.
authors.forename: Nezih
authors.initials: N
authors.lastname: Akkapulu
authors.affiliation: Department of Chair of Emergency Medicine, Ankara Training and Research Hospital, Ministry of Health, Ankara, Turkey.
authors.forename: Figen
authors.initials: F
authors.lastname: Coskun
keywords: Appendicitis; Blood Platelets; Erythrocyte Indices