title: Is intra-abdominal hypertension a missing factor that drives multiple organ dysfunction syndrome?
abstract: In a recent issue of Critical Care, Cheng and colleagues conducted a rabbit model study that demonstrated that intra-abdominal hypertension (IAH) may damage both gut anatomy and function. With only 6 hours of IAH at 25 mmHg, these authors observed an 80% reduction in mucosal blood flow, an exponential increase in mucosal permeability, and erosion and necrosis of the jejunal villi. Such dramatic findings should remind all caring for the critically ill that IAH may severely damage the normal gut barrier functions and thus may be reasonably expected to facilitate bacterial and mediator translocation. The potential contribution of IAH as a confounding factor in the efficacy of selective decontamination of the digestive tract should be considered.
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Kirkpatrick
authors.forename: Derek J
authors.initials: DJ
authors.lastname: Roberts
authors.forename: Jan
authors.initials: J
authors.lastname: De Waele
authors.forename: Kevin
authors.initials: K
authors.lastname: Laupland
mesh_terms: D000818:Animals; D007413:Intestinal Mucosa / Q000503:physiopathology*; D059325:Intra-Abdominal Hypertension / Q000503:physiopathology*; D009102:Multiple Organ Failure / Q000209:etiology*