title: Inflammatory interference of memory formation.
abstract: CD8+ memory T cells are critical for immunity against intracellular pathogens. Epidemiological evidence demonstrates that bystander infection can impact immune responses to co-infection or vaccination. A recent paper in Immunity demonstrates that persistent bystander inflammation can negatively impact CD8+ T cell effector to memory transition and protection from subsequent infection.
authors.affiliation: Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA.
authors.forename: Akshay T
authors.initials: AT
authors.lastname: Krishnamurty
authors.affiliation: Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA. Electronic address: mpepper@uw.edu.
authors.forename: Marion
authors.initials: M
authors.lastname: Pepper
mesh_terms: D000818:Animals; D024201:Bystander Effect / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002454:Cell Differentiation; D060833:Cellular Microenvironment; D002908:Chronic Disease; D060085:Coinfection; D006801:Humans; D007156:Immunologic Memory; D007249:Inflammation / Q000276:immunology*; D051379:Mice; D014612:Vaccines
chemical_list: D014612:Vaccines