title: Sevelamer in a diabetologist's perspective: a phosphate-binding resin with glucose-lowering potential.
abstract: Sevelamer is a calcium-free and metal-free phosphate-binding oral drug used in the management of hyperphosphataemia in chronic kidney disease. Preclinical and clinical trials have shown glucose and lipid-lowering effects of sevelamer, thereby giving rise to a potential role of the drug in the treatment of patients with type 2 diabetes. These 'novel' effects are most probably derived from the bile acid-binding properties of sevelamer. The proposed potential is supported by the approval of the bile acid sequestrant colesevelam in the United States for the treatment of type 2 diabetes and hypercholesterolaemia. This article offers a brief review on the effects of sevelamer and a perspective on the potential mechanisms behind the glucose-lowering effect of the drug.
authors.affiliation: Department of Medicine, Centre for Diabetes Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark; The Danish Diabetes Academy, Odense, Denmark.
authors.forename: A
authors.initials: A
authors.lastname: Brønden
authors.forename: M
authors.initials: M
authors.lastname: Hansen
authors.forename: D P
authors.initials: DP
authors.lastname: Sonne
authors.forename: U
authors.initials: U
authors.lastname: Rohde
authors.forename: T
authors.initials: T
authors.lastname: Vilsbøll
authors.forename: F K
authors.initials: FK
authors.lastname: Knop
mesh_terms: D000499:Allylamine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D000924:Anticholesteremic Agents / Q000493:pharmacokinetics / Q000494:pharmacology; D008078:Cholesterol, LDL / Q000097:blood / Q000187:drug effects; D000069472:Colesevelam Hydrochloride; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D006442:Glycated Hemoglobin / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D011073:Polyamines / Q000493:pharmacokinetics / Q000494:pharmacology*; D000069603:Sevelamer; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood
chemical_list: D000499:Allylamine; D000924:Anticholesteremic Agents; D008078:Cholesterol, LDL; D000069472:Colesevelam Hydrochloride; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D011073:Polyamines; D000069603:Sevelamer; D014280:Triglycerides; C517652:hemoglobin A1c protein, human
keywords: HbA1c; bile acid sequestrant; chronic kidney disease; diabetes; phosphate resin