title: Effects of acute sleep deprivation on motor and reversal learning in mice.
abstract: Sleep supports the formation of a variety of declarative and non-declarative memories, and sleep deprivation often impairs these types of memories. In human subjects, natural sleep either during a nap or overnight leads to long-lasting improvements in visuomotor and fine motor tasks, but rodent models recapitulating these findings have been scarce. Here we present evidence that 5h of acute sleep deprivation impairs mouse skilled reach learning compared to a matched period of ad libitum sleep. In sleeping mice, the duration of total sleep time during the 5h of sleep opportunity or during the first bout of sleep did not correlate with ultimate gain in motor performance. In addition, we observed that reversal learning during the skilled reaching task was also affected by sleep deprivation. Consistent with this observation, 5h of sleep deprivation also impaired reversal learning in the water-based Y-maze. In conclusion, acute sleep deprivation negatively impacts subsequent motor and reversal learning and memory.
authors.affiliation: Center for Neural Science, New York University, New York, NY 10003, USA; NYU Sleep Disorders Center, NYU Langone School of Medicine, New York, NY 10016, USA. Electronic address: andrew.varga@nyumc.org.
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Varga
authors.affiliation: Center for Neural Science, New York University, New York, NY 10003, USA; NYU Sleep Disorders Center, NYU Langone School of Medicine, New York, NY 10016, USA.
authors.forename: Mihwa
authors.initials: M
authors.lastname: Kang
authors.affiliation: Center for Neural Science, New York University, New York, NY 10003, USA.
authors.forename: Priyanka V
authors.initials: PV
authors.lastname: Ramesh
authors.affiliation: Center for Neural Science, New York University, New York, NY 10003, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Klann
mesh_terms: D000818:Animals; D007858:Learning / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009048:Motor Skills / Q000502:physiology*; D012193:Reversal Learning / Q000502:physiology*; D012890:Sleep / Q000502:physiology*; D012892:Sleep Deprivation / Q000503:physiopathology*
keywords: Motor learning; Reversal learning; Skilled reach learning; Sleep deprivation; Y-maze