title: The Effects of Loranthus parasiticus on Scopolamine-Induced Memory Impairment in Mice.
abstract: This study is undertaken to evaluate cognitive enhancing effect and neuroprotective effect of Loranthus parasiticus. Cognitive enhancing effect of Loranthus parasiticus was investigated on scopolamine-induced amnesia model in Morris water maze test and passive avoidance test. We also examined the neuroprotective effect on glutamate-induced cell death in HT22 cells by MTT assay. These results of Morris water maze test and passive avoidance test indicated that 10 and 50 mg/kg of Loranthus parasiticus reversed scopolamine-induced memory deficits. Loranthus parasiticus also protected against glutamate-induced cytotoxicity in HT22 cells. As a result of in vitro test for elucidating possible mechanism, Loranthus parasiticus inhibited AChE activity, ROS production, and Ca(2+) accumulation. Loranthus parasiticus showed memory enhancing effect and neuroprotective effect and these effects may be related to inhibition of AChE activity, ROS level, and Ca(2+) influx.
authors.affiliation: Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University, Hyoja 2-Dong, Chuncheon 200-701, Republic of Korea.
authors.forename: Jin Bae
authors.initials: JB
authors.lastname: Weon
authors.affiliation: Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University, Hyoja 2-Dong, Chuncheon 200-701, Republic of Korea.
authors.forename: Jiwoo
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University, Hyoja 2-Dong, Chuncheon 200-701, Republic of Korea.
authors.forename: Min Rye
authors.initials: MR
authors.lastname: Eom
authors.affiliation: Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University, Hyoja 2-Dong, Chuncheon 200-701, Republic of Korea.
authors.forename: Youn Sik
authors.initials: YS
authors.lastname: Jung
authors.affiliation: Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University, Hyoja 2-Dong, Chuncheon 200-701, Republic of Korea ; Research Institute of Biotechnology, Kangwon National University, Chuncheon 200-701, Republic of Korea.
authors.forename: Choong Je
authors.initials: CJ
authors.lastname: Ma