title: The danger of using a sledgehammer to crack a nut: ROTEM-guided administration of recombinant activated factor VII in a patient with refractory bleeding post-ventricular assist device implantation.
abstract: Recombinant activated factor VII (rFVIIa) is currently approved for treating or preventing hemorrhage in patients with hemophilia, Glanzmann's thrombasthenia, or congenital FVII deficiency. Its "off-label" use for massive bleeding in the setting of trauma or surgery has been increasing because of demonstrated efficacy. However, the use of rFVIIa also carries a high thrombo-embolic risk. This is particularly true in cardiac surgery patients, especially those treated with mechanical circulatory support. We describe the case of a patient treated with a biventricular assist device in our center, in whom severe bleeding was treated in a targeted manner, using rotational thromboelastometry to guide administration and dosing of rFVIIa. A comprehensive review of the emerging literature on the use of rFVIIa postventricular assist device implantation accompanies the case to highlight the need for careful selection of prohemostatic agents in this high-risk group.
authors: Division of Cardiac Surgery, Department of Cardiac, Thoracic and Vascular Sciences, Padova University, Padova, Italy.
authors: Vincenzo
authors: V
authors: Tarzia
authors: Edward
authors: E
authors: Buratto
authors: Giacomo
authors: G
authors: Bortolussi
authors: Carla
authors: C
authors: Paolini
authors: Jonida
authors: J
authors: Bejko
authors: Tomaso
authors: T
authors: Bottio
authors: Gino
authors: G
authors: Gerosa
mesh_terms: D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D015942:Factor VIIa / Q000008:administration & dosage* / Q000009:adverse effects; D005500:Follow-Up Studies; D006353:Heart-Assist Devices / Q000009:adverse effects*; D006490:Hemostatics / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009205:Myocarditis / Q000150:complications / Q000473:pathology; D019106:Postoperative Hemorrhage / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000009:adverse effects; D012008:Recurrence; D018570:Risk Assessment; D012720:Severity of Illness Index; D012770:Shock, Cardiogenic / Q000209:etiology / Q000601:surgery*; D013916:Thrombelastography / Q000295:instrumentation* / Q000379:methods; D013927:Thrombosis / Q000517:prevention & control; D016896:Treatment Outcome
chemical_list: D006490:Hemostatics; D011994:Recombinant Proteins; C103587:recombinant FVIIa; D015942:Factor VIIa
keywords: Bleeding; NovoSeven; Recombinant activated factor; Thromboelastometry; Ventricular assist device