title: Impact of intraoperative topical hydroxypropyl methylcellulose 2% versus sodium hyaluronate 1.2% on corneal reepithelialization after intentional epithelial debridement during vitrectomy.
abstract: OBJECTIVE
  The aim of this study was to assess the impact of the intraoperative use of topical hydroxypropyl methylcellulose (HPMC) 2% versus sodium hyaluronate 1.2% on corneal reepithelialization time and final corneal status after intentional epithelial debridement during vitrectomy for proliferative vitreoretinopathy.
  
  
  METHODS
  Forty eyes of 40 patients were included in the study, divided into 2 groups of 20 eyes. HPMC 2% and sodium hyaluronate 1.2% were used as corneal protectors in the first and second group, respectively. Patients' charts were reviewed to determine any differences between the HPMC 2% and sodium hyaluronate 1.2% groups in relation to the preoperative, intraoperative, and postoperative factors that could impact postoperative corneal reepithelialization. Postoperative reepithelialization time and final corneal status were recorded.
  
  
  RESULTS
  No significant between-group differences in preoperative, intraoperative, and postoperative factors were found. Reepithelialization time was significantly shorter in the sodium hyaluronate 1.2% group than in the HPMC 2% group, although reepithelialization was eventually achieved in every patient in both groups. Corneal sequelae were significantly more frequent in the HPMC 2% group than in the sodium hyaluronate 1.2% group.
  
  
  CONCLUSIONS
  The choice of the ophthalmic viscosurgical device for intraoperative corneal protection may significantly influence the postoperative corneal status after complicated retinal detachment.
authors: Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.
authors: Gian Marco
authors: GM
authors: Tosi
authors: Davide
authors: D
authors: Marigliani
authors: Tommaso
authors: T
authors: Bacci
authors: Angelo
authors: A
authors: Balestrazzi
authors: Gianluca
authors: G
authors: Martone
authors: Maria Sole
authors: MS
authors: Polito
mesh_terms: D000287:Administration, Topical; D000368:Aged; D003646:Debridement; D019573:Epithelium, Corneal / Q000502:physiology*; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D065347:Hypromellose Derivatives / Q000627:therapeutic use*; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D062326:Re-Epithelialization / Q000502:physiology*; D055675:Viscosupplements / Q000627:therapeutic use*; D014821:Vitrectomy; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D009883:Ophthalmic Solutions; D055675:Viscosupplements; D065347:Hypromellose Derivatives; D006820:Hyaluronic Acid