title: Low modulus Ti-Nb-Hf alloy for biomedical applications.
abstract: β-Type titanium alloys with a low elastic modulus are a potential strategy to reduce stress shielding effect and to enhance bone remodeling in implants used to substitute failed hard tissue. For biomaterial application, investigation on the mechanical behavior, the corrosion resistance and the cell response is required. The new Ti25Nb16Hf alloy was studied before and after 95% cold rolling (95% C.R.). The mechanical properties were determined by tensile testing and its corrosion behavior was analyzed by potentiostatic equipment in Hank's solution at 37°C. The cell response was studied by means of cytotoxicity evaluation, cell adhesion and proliferation measurements. The stress-strain curves showed the lowest elastic modulus (42GPa) in the cold worked alloy and high tensile strength, similar to that of Ti6Al4V. The new alloy exhibited better corrosion resistance in terms of open circuit potential (EOCP), but was similar in terms of corrosion current density (iCORR) compared to Ti grade II. Cytotoxicity studies revealed that the chemical composition of the alloy does not induce cytotoxic activity. Cell studies in the new alloy showed a lower adhesion and a higher proliferation compared to Ti grade II presenting, therefore, mechanical features similar to those of human cortical bone and, simultaneously, a good cell response.
authors: Department of Materials Science and Metallurgy, Universitat Politècnica de Catalunya (UPC), Avda. Diagonal 647, 08028 Barcelona, Spain; Materials Science, Elisava Escola Superior de Disseny i Enginyeria de Barcelona, La Rambla 30-32, 08002 Barcelona, Spain. Electronic address: Marta.Gonzalez.Colominas@upc.edu.
authors: M
authors: M
authors: González
authors: Department of Materials Science and Metallurgy, Universitat Politècnica de Catalunya (UPC), Avda. Diagonal 647, 08028 Barcelona, Spain; Materials Science, Elisava Escola Superior de Disseny i Enginyeria de Barcelona, La Rambla 30-32, 08002 Barcelona, Spain.
authors: J
authors: J
authors: Peña
authors: Department of Materials Science and Metallurgy, Universitat Politècnica de Catalunya (UPC), Avda. Diagonal 647, 08028 Barcelona, Spain; Ciber-BBN, Spain.
authors: F J
authors: FJ
authors: Gil
authors: Department of Materials Science and Metallurgy, Universitat Politècnica de Catalunya (UPC), Avda. Diagonal 647, 08028 Barcelona, Spain; Ciber-BBN, Spain.
authors: J M
authors: JM
authors: Manero
mesh_terms: D000497:Alloys / Q000737:chemistry* / Q000633:toxicity; D001672:Biocompatible Materials / Q000737:chemistry* / Q000633:toxicity; D002448:Cell Adhesion / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003343:Corrosion; D055119:Elastic Modulus; D006801:Humans; D008422:Materials Testing; D013314:Stress, Mechanical; D028561:Transition Elements / Q000737:chemistry* / Q000633:toxicity
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D028561:Transition Elements
keywords: Biocompatibility; Corrosion; Cytotoxicity; Low elastic modulus; Stress shielding effect; TiNbHf alloys