title: Sox2, a marker for stem-like tumor cells in skin squamous cell carcinoma and hedgehog subgroup medulloblastoma.
abstract: Heterogeneity within tumors is becoming increasingly recognized as an important cause of treatment failure in cancer. Two recent studies use fate-mapping and limiting dilution transplantation assays to identify SRY (sex determining region Y)-box 2 (Sox2) as cancer stem-cell marker and driver of cancer stemness.
authors: Division of Pediatric Hematology-Oncology, Duke University Medical Center, Durham, NC, USA Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.
authors: Oren J
authors: OJ
authors: Becher
authors: Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA Alvord Brain Tumor Center, University of Washington, Seattle, WA, USA.
authors: Eric C
authors: EC
authors: Holland
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D002528:Cerebellar Neoplasms / Q000378:metabolism*; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D005260:Female; D053823:Hedgehog Proteins / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000235:genetics* / Q000378:metabolism*; D014411:Neoplastic Stem Cells / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000037:antagonists & inhibitors* / Q000235:genetics*; D055748:SOXB1 Transcription Factors / Q000378:metabolism*; D012878:Skin Neoplasms
chemical_list: D014408:Biomarkers, Tumor; D053823:Hedgehog Proteins; D043562:Receptors, G-Protein-Coupled; D055748:SOXB1 Transcription Factors