title: A retrospective analysis of ten symptomatic multiple myeloma patients with HIV infection: a potential therapeutic effect of HAART in multiple myeloma.
abstract: The impact of highly active anti-retroviral therapy (HAART) in multiple myeloma (MM) is unknown. Ten HIV+ and 28 HIV-negative patients were retrospectively identified out of 262 cases of MM diagnosed at Kings County Hospital Center since the introduction of HAART in 1996. The HIV+ MM patients on HAART had superior overall survival (OS) (Fisher exact, p=0.008; log-rank, p=0.012) and progression free survival (PFS) (Fisher exact, p=0.007; log-rank, p=0.009) than the HIV-negative MM patients. HAART alone blocked the production of serum M-protein. We propose that HARRT should be explored for the treatment of both HIV+ and HIV-negative MM patients.
authors: Department of Pathology, SUNY Downstate Medical Center, Kings County Hospital Center, Brooklyn, NY, United States.
authors: Geling
authors: G
authors: Li
authors: Department of Haematology/Oncology, SUNY Downstate Medical Center, Kings County Hospital Center, Brooklyn, NY, United States.
authors: Robert D
authors: RD
authors: Lewis
authors: Department of Haematology/Oncology, SUNY Downstate Medical Center, Kings County Hospital Center, Brooklyn, NY, United States.
authors: Nidhi
authors: N
authors: Mishra
authors: Department of Pathology, SUNY Downstate Medical Center, Kings County Hospital Center, Brooklyn, NY, United States. Electronic address: axiotismd@aol.com.
authors: Constantine A
authors: CA
authors: Axiotis
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D016022:Case-Control Studies; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000188:drug therapy* / Q000401:mortality; D012189:Retrospective Studies; D016019:Survival Analysis
keywords: HARRT; HIV; Monoclonal protein; Multiple myeloma; Survival