title: Could HLA-DR B1*11 allele be a clue for predicting extra-pulmonary sarcoidosis?
abstract: BACKGROUND
  Several HLA-DR alleles have been described as a potential risk factor for sarcoidosis between distinct ethnic groups however the relationship between HLA-DR alleles and extra-pulmonary sarcoidosis (EPS) is still scarce.
  
  
  OBJECTIVE
  The aim of this prospective study is to investigate the relationship between extra-pulmonary involvement and HLA-DR genetic analysis in Turkish patients with sarcoidosis.
  
  
  METHODS
  In this study, we HLA-typed sarcoidosis patients with and without extra-pulmonary involvement, and compared with healthy control subjects. The presence of EPS was evaluated with previously defined standard criteria (ACCESS) and only patients with definite and probable involvement were accepted as positive. Sequence Specific Oligonucletide Probes method was used for typing of HLA-DRB1 alleles from DNA samples in both groups.
  
  
  RESULTS
  The frequency of HLA DRB1*15 allele was more frequent in patients with sarcoidosis than controls (% 20.4 vs % 9.6)(pcorr=0.017). According to multivariate analysis (MVA), the presence of HLA DRB1*15 was indicated as an independent risk factor for sarcoidosis (OR:2.37; 95% CI: 1.31-4.30, p=0.004). Extra-pulmonary involvement was present in 39 patients (42.9 %). When the patients with and without extra-pulmonary involvement compared, HLADRB1*11 allele was significantly higher in patients without extra-pulmonary sarcoidosis which may be concluded as a protective allele for systemic involvement (%30.8 vs. %15.4)(p&lt;0.05). This result was also confirmed with the MVA (OR:0.35, %95 CI:0.15-0.84, p=0.018).
  
  
  CONCLUSIONS
  We demonstrated a strong positive link between the haplotype HLA DRB1*15 and sarcoidosis in a Turkish Caucasian population and a potential protective effect of HLA DRB1*11 from extra-pulmonary involvement of disease.
authors: Cukurova University. ezgiozyilmaz@hotmail.com.
authors: Ezgi
authors: E
authors: Ozyilmaz
authors: Ozlem
authors: O
authors: Goruroglu Ozturk
authors: Dilek
authors: D
authors: Yunsel
authors: Ali
authors: A
authors: Deniz
authors: Ismail
authors: I
authors: Hanta
authors: Sedat
authors: S
authors: Kuleci
authors: Gulsah
authors: G
authors: Seydaoglu
authors: Eren
authors: E
authors: Erken
authors: Ali
authors: A
authors: Kocabas
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D059811:HLA-DRB1 Chains / Q000235:genetics* / Q000276:immunology; D006239:Haplotypes; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D011446:Prospective Studies; D065840:Protective Factors; D018570:Risk Assessment; D012307:Risk Factors; D012507:Sarcoidosis / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D014421:Turkey / Q000453:epidemiology; D044465:White People / Q000235:genetics
chemical_list: D059811:HLA-DRB1 Chains