title: HLA-B51 subtypes in Turkish patients with Behçet's disease and their correlation with clinical manifestations.
abstract: Behçet's disease (BD) is a multisystemic inflammatory disease believed to be triggered by microbial or environmental factors on a genetic platform. Clinically, it may have an impact on many body systems, including the mucocutaneous, ocular, articular, vascular, and neurological systems. In this study, we aimed to determine the HLA-B51 subtypes and their correlations with the clinical findings of BD. Fifty-one patients with BD and 44 gender- and age-matched healthy subjects were included in this study. The HLA-B51 subtypes of all participants were determined, and the correlations of the clinical manifestations of the disease with the HLA-B51 subtypes were analyzed. HLA-B51 positivity was found to be significantly higher in the patient group (P < 0.001, RR = 15.20), which had significantly more frequent HLA-B5101, HLA-B5102(01), HLA-B5109, and HLA-B5122 subtypes than the healthy subjects (all P < 0.05). Furthermore, considering the correlation between the genetic makeup and clinical findings, the HLA-B5109 subtype was found to be less frequent in patients with papulopustular skin lesions (P = 0.042). The frequency of HLA-B5103 was significantly higher in patients with central nervous system involvement (P = 0.015). There may be a relationship between HLA-B5102(01), HLA-B5109, and HLA-B5122 in addition to HLA-B51 and HLA-B5101(01) in Turkish patients with BD. The HLA-B5109 subtype can be protective against papulopustular lesion development; however, the HLA-B5103 subtype may pose a risk for neuro-Behçet development in BD.
authors: Department of Dermatology, Ankara Ataturk Training and Research Hospital, Ankara, Turkey ddemirseren@yahoo.com.
authors: D D
authors: DD
authors: Demirseren
authors: Department of Medical Genetics, Ankara Ataturk Training and Research Hospital, Ankara, Turkey.
authors: G G
authors: GG
authors: Ceylan
authors: Department of Dermatology, Ankara Ataturk Training and Research Hospital, Ankara, Turkey.
authors: G
authors: G
authors: Akoglu
authors: Department of Dermatology, Ankara Ataturk Training and Research Hospital, Ankara, Turkey.
authors: S
authors: S
authors: Emre
authors: Department of Rheumatology, Ankara Ataturk Training and Research Hospital, Ankara, Turkey.
authors: S
authors: S
authors: Erten
authors: Department of Ophthalmology, Ankara Ataturk Training and Research Hospital, Ankara, Turkey.
authors: A
authors: A
authors: Arman
authors: Department of Dermatology, Ankara Ataturk Training and Research Hospital, Ankara, Turkey.
authors: A
authors: A
authors: Metin
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D001528:Behcet Syndrome / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D015870:Gene Expression; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D059949:HLA-B51 Antigen / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009420:Nervous System / Q000276:immunology / Q000473:pathology*; D019226:Oral Ulcer / Q000276:immunology / Q000473:pathology*; D010641:Phenotype; D012867:Skin / Q000276:immunology / Q000473:pathology*; D014421:Turkey
chemical_list: D059949:HLA-B51 Antigen