title: Roles of lncRNAs in pancreatic beta cell identity and diabetes susceptibility.
abstract: Type 2 diabetes usually ensues from the inability of pancreatic beta cells to compensate for incipient insulin resistance. The loss of beta cell mass, function, and potentially beta cell identity contribute to this dysfunction to extents which are debated. In recent years, long non-coding RNAs (lncRNAs) have emerged as potentially providing a novel level of gene regulation implicating critical cellular processes such as pluripotency and differentiation. With over 1000 lncRNAs now identified in beta cells, there is growing evidence for their involvement in the above processes in these cells. While functional evidence on individual islet lncRNAs is still scarce, we discuss how lncRNAs could contribute to type 2 diabetes susceptibility, particularly at loci identified through genome-wide association studies as affecting disease risk.
authors: Section of Cell Biology, Department of Medicine, Imperial Centre for Translational and Experimental Medicine, Imperial College London London, UK.
authors: Timothy J
authors: TJ
authors: Pullen
authors: Section of Cell Biology, Department of Medicine, Imperial Centre for Translational and Experimental Medicine, Imperial College London London, UK.
authors: Guy A
authors: GA
authors: Rutter
keywords: beta cell; cell identity; genome-wide association studies; islets of Langerhans; lncRNAs; type 2 diabetes