title: Use of micro-focused ultrasound with visualization to lift and tighten lax knee skin (1.).
abstract: BACKGROUND
  Public interest in noninvasive, aesthetic treatments for the rejuvenation of appearance continues to grow. The following prospective, open-label, nonrandomized trial was conducted to evaluate the safety and efficacy of micro-focused ultrasound with visualization (MFU-V) for achieving lift and tightening of lax skin above the knee.
  
  
  METHODS
  Healthy adult women (N = 30) with mild- to moderate bilateral skin laxity above the knees were enrolled. MFU-V was applied to a grid of eight 25 mm(2) squares above each knee. MFU-V was first applied using a 4 MHz, 4.5 mm transducer followed by a 7 MHz, 3.0 mm transducer. Approximately 320 treatment lines applied to each knee [corrected]. The primary efficacy endpoint was lifting and tightening of lax skin above the knee as determined by the principle investigator using the Physician Global Aesthetic Improvement Scale (PGAIS).
  
  
  RESULTS
  Among 28 evaluable subjects, 24 subjects (86%) showed improved lifting and tightening of knee skin laxity at 90- and 180-day follow-up visits. Three subjects showed no change and the appearance of one subject worsened. There were no adverse events or evidence of skin injury.
  
  
  CONCLUSIONS
  Similar to its safety and efficacy for tightening facial skin and reducing wrinkles, MFU-V is an effective, noninvasive method for reducing skin laxity and improving the appearance of skin above the knee. ClinicalTrials.gov Identifier: NCT01708434.
authors: Tennessee Clinical Research Center , Nashville, TN , USA.
authors: Michael H
authors: MH
authors: Gold
authors: Whitney
authors: W
authors: Sensing
authors: Julie
authors: J
authors: Biron
mesh_terms: D000328:Adult; D003357:Cosmetic Techniques / Q000295:instrumentation*; D005260:Female; D006801:Humans; D007717:Knee; D008875:Middle Aged; D017060:Patient Satisfaction; D011446:Prospective Studies; D012060:Rejuvenation; D015595:Skin Aging; D014464:Ultrasonic Therapy / Q000295:instrumentation*
keywords: clinical trial; knees; micro-focused ultrasound; noninvasive; skin lifting; skin tightening