title: Catabolite control protein A is an important regulator of metabolism inStreptococcus suistype 2.
abstract: Streptococcus suis(S. suis) type 2 is an extremely important Gram-positive bacterial pathogen that can cause human or swine endocarditis, meningitis, bronchopneumonia, arthritis and sepsis. Catabolite control protein A (CcpA) is a major transcriptional regulator inS. suistype 2 that functions in catabolite control, specifically during growth on glucose or galactose. The regulation of central metabolism can affect the virulence of bacteria. In the present study, a metabolomics approach was used along with principal components analysis (PCA) and partial least-squares-discriminant analysis (PLS-DA) models and 37 metabolites were found that differed substantially between nativeS. suisand a mutant lacking CcpA. These results showed that CcpA is an important protein inS. suistype 2 for studying bacterial protein function.
authors: Institute of Military Veterinary, Academy of Military Medical Sciences, Jilin Agricultural University, Changchun, Jilin 130122, P.R. China ; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Jilin Agricultural University, Changchun, Jilin 130122, P.R. China.
authors: Xulong
authors: X
authors: Lang
authors: Institute of Military Veterinary, Academy of Military Medical Sciences, Jilin Agricultural University, Changchun, Jilin 130122, P.R. China ; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Jilin Agricultural University, Changchun, Jilin 130122, P.R. China.
authors: Zhonghai
authors: Z
authors: Wan
authors: Institute of Military Veterinary, Academy of Military Medical Sciences, Jilin Agricultural University, Changchun, Jilin 130122, P.R. China ; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Jilin Agricultural University, Changchun, Jilin 130122, P.R. China.
authors: Zhaoyang
authors: Z
authors: Bu
authors: School of Life Science, Jilin Agricultural University, Changchun, Jilin 130122, P.R. China.
authors: Xiuran
authors: X
authors: Wang
authors: Institute of Military Veterinary, Academy of Military Medical Sciences, Jilin Agricultural University, Changchun, Jilin 130122, P.R. China ; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Jilin Agricultural University, Changchun, Jilin 130122, P.R. China.
authors: Xiaoxu
authors: X
authors: Wang
authors: Institute of Military Veterinary, Academy of Military Medical Sciences, Jilin Agricultural University, Changchun, Jilin 130122, P.R. China ; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Jilin Agricultural University, Changchun, Jilin 130122, P.R. China.
authors: Lingwei
authors: L
authors: Zhu
authors: Institute of Military Veterinary, Academy of Military Medical Sciences, Jilin Agricultural University, Changchun, Jilin 130122, P.R. China ; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Jilin Agricultural University, Changchun, Jilin 130122, P.R. China.
authors: Jiayu
authors: J
authors: Wan
authors: Institute of Military Veterinary, Academy of Military Medical Sciences, Jilin Agricultural University, Changchun, Jilin 130122, P.R. China ; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Jilin Agricultural University, Changchun, Jilin 130122, P.R. China.
authors: Yang
authors: Y
authors: Sun
authors: Institute of Military Veterinary, Academy of Military Medical Sciences, Jilin Agricultural University, Changchun, Jilin 130122, P.R. China ; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Jilin Agricultural University, Changchun, Jilin 130122, P.R. China.
authors: Xinglong
authors: X
authors: Wang
keywords: Streptococcus suis type 2; carbon control protein A; metabolomics