title: [Effects of electroacupuncture stimulation of "Daimai" (GB 26) on body weight, blood glucose and blood lipid levels in rats with metabolism syndrome].
abstract: OBJECTIVE
  To observe the therapeutic effect of electroacupuncture (EA) stimulation of "Daimai" (GB 26) on metabolic syndrome in rats.
  
  
  METHODS
  SD rats were randomly divided into blank control group (n = 9), model group (n = 9) and EA group (n = 9). The metabolic syndrome model was established by feeding the rats with high fat and sugar forage (containing 20% lard, 10% cane sugar, 10% defatted milk powder, 2% cholest, 3% yolk powder and 55% normal forage) for 12 weeks. EA (2 Hz/100 Hz, 1-2 mA) was applied to bilateral "Daimai" (GB 26) for 20 min, once daily for 4 weeks. Fasting blood glucose (FBG), serum triglyceride (TG), total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C), lower density lipoprotein-cholesterol (LDL-C) contents were detected using chemical methods,fasting serum insulin (FINS) was determined by using radioimmunoassay. Homeostasis model assessment-index of resistance (HOMA-IR, insulin resistance index = FBG x FINS/22.5) was calculated.
  
  
  RESULTS
  Compared to the blank control group, the body weight (from the 8th week on),abdominal circumference (from the 4th week on), and FBG, FINS, TG, TC, LDL-C contents as well as HOMA-IR in the model group were significantly increased (P < 0.05, P < 0.01), while the HDL-C content was considerably lowered after modeling (P < 0.05). In comparison with the model group, the body weight on the 16th week, FBG, FINS, HOMA-IR, TG, TC and LDL-C levels were evidently down-regulated in the EA group (P < 0.05, P < 0.01). No significant differences were found between the model and EA groups in the abdominal circumference and HDL-C content (P > 0.05).
  
  
  CONCLUSIONS
  Electroacupuncture stimulation of "Daimai" (GB 26) can reduce insulin resistance, regulate blood lipid, and lower blood glucose in metabolic syndrome rats.
authors: Yuan-Yuan
authors: YY
authors: Li
authors: Hui
authors: H
authors: Hu
authors: Cui-Mei
authors: CM
authors: Liang
authors: Hui
authors: H
authors: Wang
mesh_terms: D015669:Acupuncture Points; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001835:Body Weight; D015671:Electroacupuncture; D006801:Humans; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood*; D008297:Male; D008659:Metabolic Diseases / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D017207:Rats, Sprague-Dawley
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008055:Lipids