title: Prenatal exposure to phenols and growth in boys.
abstract: BACKGROUND
  Phenols interact with nuclear receptors implicated in growth and adipogenesis regulation. Only a few studies have explored their effects on growth in humans.
  
  
  OBJECTIVE
  We studied the associations of maternal exposure to phenols during pregnancy with prenatal and postnatal growth of male newborns.
  
  
  METHODS
  Within a cohort of women recruited during pregnancy, we selected 520 mother-son pairs and quantified 9 phenols in spot urine samples collected during pregnancy. We used ultrasonography during pregnancy, together with birth measurements, to assess fetal growth. We modeled individual postnatal growth trajectories from repeated measures of weight and height in the first 3 years of life.
  
  
  RESULTS
  Triclosan concentration was negatively associated with growth parameters measured at the third ultrasound examination but not earlier in pregnancy. At birth, this phenol tended to be negatively associated with head circumference (-1.2 mm for an interquartile range [IQR] increase in ln-transformed triclosan concentration [95% confidence interval = -2.6 to 0.3]) but not with weight or height. Parabens were positively associated with weight at birth. This positive association remained for 3 years for methylparaben (β = 193 g [-4 to 389]) for an IQR increase in ln-transformed concentrations.
  
  
  CONCLUSIONS
  We relied on only 1 spot urine sample to assess exposure; because of the high variability in phenol urinary concentrations reported during pregnancy, using only 1 sample may result in exposure misclassification, in particular for bisphenol A. Our study suggested associations between prenatal exposure to parabens and triclosan and prenatal or early postnatal growth.
authors: From the aInserm, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France; bUniversity of Grenoble Alpes, IAB, Grenoble, France; cInserm, Center for research in Epidemiology and Population Health, U1018, Team Epidemiology of Diabetes, Obesity and Renal Disease: Lifelong Approach, Villejuif, France; dUniversité Paris-Sud, Faculty of Pharmacy, Châtenay-Malabry, France; and eCenters for Disease Control and Prevention, Atlanta, GA.
authors: Claire
authors: C
authors: Philippat
authors: Jérémie
authors: J
authors: Botton
authors: Antonia M
authors: AM
authors: Calafat
authors: Xiaoyun
authors: X
authors: Ye
authors: Marie-Aline
authors: MA
authors: Charles
authors: Rémy
authors: R
authors: Slama
mesh_terms: D000328:Adult; D001724:Birth Weight / Q000187:drug effects; D001827:Body Height / Q000187:drug effects; D002657:Child Development / Q000187:drug effects*; D002675:Child, Preschool; D015331:Cohort Studies; D004785:Environmental Pollutants / Q000633:toxicity* / Q000652:urine; D005260:Female; D047109:Fetal Development / Q000187:drug effects*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016014:Linear Models; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects*; D010636:Phenols / Q000633:toxicity* / Q000652:urine; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced*; D016216:Ultrasonography, Prenatal; D015430:Weight Gain / Q000187:drug effects
chemical_list: D004785:Environmental Pollutants; D010636:Phenols