title: Protective effect of polydatin, a natural precursor of resveratrol, against cisplatin-induced toxicity in rats.
abstract: The aim of the present study was to evaluate the possible protective effect of polydatin (PD) on cisplatin (Cis) induced oxidative stress in rats. Totally, thirty male Wistar albino rats were fed standard rodent diet and divided into 5 equal groups: the control group (vehicle treated) was treated with physiological saline for ten days both orally and intraperitoneally (i.p.), the second group was orally treated with physiological saline and 7 mg/kg single i.p. injection of Cis on the seventh day, and third, fourth, and fifth groups were treated orally PD at 25, 50, and 100 mg/kg/day, respectively for 10 days starting seven days before Cis injection and 7 mg/kg single i.p. Cis was injected on the seventh day. Cis resulted in significant increase malondialdehyde levels and decreased glutathione levels. In addition, Cis treatment decreased superoxide dismutase and catalase activities in erythrocyte and tissues. Also, Cis treatment caused to increase DNA damage and affected serum biochemical parameters whereas slightly decreased AchE activity. However, treatment of PD resulted in reversal of Cis-induced oxidative stress, lipid peroxidation, and activities of antioxidant enzymes. In conclusion, PD has protective effect in rats against Cis-induced oxidative stress, enhances antioxidant defence mechanism, and regenerates their tissues.
authors: Afyon Kocatepe University, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, 03030 Afyonkarahisar, Turkey. Electronic address: since@aku.edu.tr.
authors: Sinan
authors: S
authors: Ince
authors: Afyon Kocatepe University, Faculty of Veterinary Medicine, Department of Biochemistry, 03030 Afyonkarahisar, Turkey.
authors: Damla
authors: D
authors: Arslan Acaroz
authors: University of Veterinary and Pharmaceutical Sciences, Faculty of Pharmacy, Department of Natural Drugs, CZ 612 42 Brno, Czech Republic.
authors: Ondřej
authors: O
authors: Neuwirth
authors: Afyon Kocatepe University, Bayat Vocational School, Afyonkarahisar, Turkey.
authors: Hasan Huseyin
authors: HH
authors: Demirel
authors: Afyon Kocatepe University, Faculty of Veterinary Medicine, Department of Biochemistry, 03030 Afyonkarahisar, Turkey.
authors: Baris
authors: B
authors: Denk
authors: Afyon Kocatepe University, Faculty of Veterinary Medicine, Department of Biochemistry, 03030 Afyonkarahisar, Turkey.
authors: Ismail
authors: I
authors: Kucukkurt
authors: Afyon Kocatepe University, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, 03030 Afyonkarahisar, Turkey.
authors: Ruhi
authors: R
authors: Turkmen
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002374:Catalase / Q000378:metabolism; D002945:Cisplatin / Q000009:adverse effects*; D004249:DNA Damage / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects; D005960:Glucosides / Q000494:pharmacology*; D005978:Glutathione / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D005960:Glucosides; D013267:Stilbenes; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione; D002945:Cisplatin; D000077185:Resveratrol; C058229:polydatin
keywords: Cisplatin; DNA damage; Oxidative stress; Polydatin; Rat; Toxicity