title: Simultaneous investigation of vascular and retinal pigment epithelial pathologies of exudative macular diseases by multifunctional optical coherence tomography.
abstract: OBJECTIVE
  To investigate exudative macular disease, multifunctional optical coherence tomography (MF-OCT) using a 1-μm probe band was developed. The clinical utility of MF-OCT was examined in a descriptive case series.
  
  
  METHODS
  Ten eyes of nine subjects with exudative macular disease, including one eye with age-related macular degeneration (AMD), one eye with idiopathic neovascular maculopathy, and eight eyes with polypoidal choroidal vasculopathy (PCV), were investigated. Areas of 6 × 6 mm(2) around the pathologic region were scanned with 512 × 1024 depth scans in 6.6 seconds. Structural OCT, Doppler optical coherence angiography (OCA), and cumulative phase retardation images were obtained with a single measurement. Each MF-OCT image visualized the structure, vasculature, and birefringence. Degree of polarization uniformity values were also obtained for selective visualization of the retinal pigment epithelium (RPE). The MF-OCT images were compared with conventional ophthalmic images.
  
  
  RESULTS
  Abnormal vasculatures were observed with Doppler OCA in all eyes, which presented high similarity to indocyanine green angiography in the midphase. The RPE and exudation in the pathologic regions were discriminated in one eye with AMD and five of eight eyes with PCV. Cumulative phase retardation visualized fibrosis scars in two of the PCV cases.
  
  
  CONCLUSIONS
  Multifunctional OCT revealed depth-resolved abnormal vasculatures, the integrity of the RPE and choroid, discrimination of the RPE and exudation, and existence of fibrosis scars in exudative macular diseases. Interpretation of MF-OCT examination is well matched with conventional ophthalmic examination. These results suggest that MF-OCT can be used as a noninvasive ophthalmic examination tool prior to conventional examinations in clinical routines.
authors: Computational Optics Group, University of Tsukuba, Tsukuba, Ibaraki, Japan Computational Optics and Ophthalmology Group, Tsukuba, Ibaraki, Japan.
authors: Young-Joo
authors: YJ
authors: Hong
authors: Computational Optics and Ophthalmology Group, Tsukuba, Ibaraki, Japan Department of Ophthalmology, Ibaraki Medical Center, Tokyo Medical University, Ami, Ibaraki, Japan.
authors: Masahiro
authors: M
authors: Miura
authors: Electrical and Computer Engineering, University of British Columbia, Vancouver, British Columbia, Canada.
authors: Myeong Jin
authors: MJ
authors: Ju
authors: Computational Optics Group, University of Tsukuba, Tsukuba, Ibaraki, Japan Computational Optics and Ophthalmology Group, Tsukuba, Ibaraki, Japan.
authors: Shuichi
authors: S
authors: Makita
authors: Department of Ophthalmology, Ibaraki Medical Center, Tokyo Medical University, Ami, Ibaraki, Japan.
authors: Takuya
authors: T
authors: Iwasaki
authors: Computational Optics Group, University of Tsukuba, Tsukuba, Ibaraki, Japan Computational Optics and Ophthalmology Group, Tsukuba, Ibaraki, Japan.
authors: Yoshiaki
authors: Y
authors: Yasuno
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D008268:Macular Degeneration / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D055213:Retinal Pigment Epithelium / Q000473:pathology*; D012171:Retinal Vessels / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods*
keywords: OCT angiography; exudative macular disease; optical coherence tomography; polarization-sensitive OCT; retinal pigment epithelium