title: Relationship between the complement system, risk factors and prediction models in age-related macular degeneration.
abstract: Studies performed over the past decade in humans and experimental animals have been a major source of information and improved our understanding of how dysregulation of the complement system contributes to age-related macular degeneration (AMD) pathology. Drusen, the hall-mark of dry-type AMD are reported to be the by-product of complement mediated inflammatory processes. In wet AMD, unregulated complement activation results in increased production of angiogenic growth factors leading to choroidal neovascularization both in humans and in animal models. In this review article we have linked the complement system with modifiable and non-modifiable AMD risk factors as well as with prediction models of AMD. Understanding the association between the complement system, risk factors and prediction models will help improve our understanding of AMD pathology and management of this disease.
authors: Department of Ophthalmology, Jones Eye Institute, Pat and Willard Walker Eye Research Center, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, AR 72205, USA. Electronic address: nbora@uams.edu.
authors: Nalini S
authors: NS
authors: Bora
authors: Department of Ophthalmology, Jones Eye Institute, Pat and Willard Walker Eye Research Center, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, AR 72205, USA.
authors: Bharati
authors: B
authors: Matta
authors: Department of Ophthalmology, Jones Eye Institute, Pat and Willard Walker Eye Research Center, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, AR 72205, USA.
authors: Valeriy V
authors: VV
authors: Lyzogubov
authors: Department of Ophthalmology, Jones Eye Institute, Pat and Willard Walker Eye Research Center, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, AR 72205, USA.
authors: Puran S
authors: PS
authors: Bora
mesh_terms: D000818:Animals; D003165:Complement System Proteins / Q000276:immunology*; D004195:Disease Models, Animal; D006801:Humans; D008268:Macular Degeneration / Q000276:immunology*; D008954:Models, Biological; D012307:Risk Factors
chemical_list: D003165:Complement System Proteins
keywords: Age-related macular degeneration; Choroid; Complement system; Prediction models; Retina; Risk factors