title: Parental smoking and childhood obesity: higher effect estimates for maternal smoking in pregnancy compared with paternal smoking--a meta-analysis.
abstract: BACKGROUND
  Some studies reported similar effect estimates for the impact of maternal smoking in pregnancy and paternal smoking on childhood obesity, whereas others suggested higher effects for maternal smoking. We performed a meta-analysis to compare the effect of in utero exposure to maternal smoking and that of paternal or household smoking exposure in utero or after birth with mutual adjustment.
  
  
  METHODS
  Meta-analysis of observational studies identified in MEDLINE, EMBASE and Web of Knowledge published in 1900-2013. Study inclusion criterion was assessment of the association of maternal smoking during pregnancy and paternal or household smoking (anyone living in the household who smokes) at any time with childhood overweight and obesity. The analyses were based on all studies with mutually adjusted effect estimates for maternal and paternal/household smoking applying a random-effects model.
  
  
  RESULTS
  Data for 109,838 mother/child pairs were reported in 12 studies. The pooled odds ratios (ORs) for overweight 1.33 [95% confidence interval (CI) 1.23;1.44] (n=6, I2=0.00%) and obesity 1.60 (95% CI 1.37;1.88) (n=4, I2=32.47%) for maternal smoking during pregnancy were higher than for paternal smoking: 1.07 (95% CI 1.00;1.16) (n=6, I2=41.34%) and 1.23 (95% CI 1.10;1.38) (n=4, I2=14.61%), respectively. Similar estimates with widely overlapping confidence limits were found for maternal smoking during pregnancy and childhood overweight and obesity: 1.35 (95% CI 1.20;1.51) (n=3, I2=0.00%) and 1.28 (95% CI 1.07;1.54) (n=3, I2=0.00%) compared with household smoking 1.22 (95% CI 1.06;1.39) (n=3, I2=72.14%) and 1.31 (95% CI 1.15;1.50)] (n=3, I2=0.00%).
  
  
  CONCLUSIONS
  Higher effect estimates for maternal smoking in pregnancy compared with paternal smoking in mutually adjusted models may suggest a direct intrauterine effect.
authors: Ludwig Maximilian University of Munich, Institute of Social Paediatrics and Adolescent Medicine, Munich, Germany, Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Canada, Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, UK, Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan, Department of Family Medicine, Taipei City Hospital, ZhongXing Branch, Taipei, Taiwan and Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney, Australia christina.riedel@med.uni-muenchen.de.
authors: Christina
authors: C
authors: Riedel
authors: Ludwig Maximilian University of Munich, Institute of Social Paediatrics and Adolescent Medicine, Munich, Germany, Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Canada, Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, UK, Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan, Department of Family Medicine, Taipei City Hospital, ZhongXing Branch, Taipei, Taiwan and Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney, Australia.
authors: Katharina
authors: K
authors: Schönberger
authors: Ludwig Maximilian University of Munich, Institute of Social Paediatrics and Adolescent Medicine, Munich, Germany, Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Canada, Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, UK, Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan, Department of Family Medicine, Taipei City Hospital, ZhongXing Branch, Taipei, Taiwan and Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney, Australia.
authors: Seungmi
authors: S
authors: Yang
authors: Ludwig Maximilian University of Munich, Institute of Social Paediatrics and Adolescent Medicine, Munich, Germany, Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Canada, Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, UK, Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan, Department of Family Medicine, Taipei City Hospital, ZhongXing Branch, Taipei, Taiwan and Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney, Australia.
authors: Gibby
authors: G
authors: Koshy
authors: Ludwig Maximilian University of Munich, Institute of Social Paediatrics and Adolescent Medicine, Munich, Germany, Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Canada, Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, UK, Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan, Department of Family Medicine, Taipei City Hospital, ZhongXing Branch, Taipei, Taiwan and Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney, Australia Ludwig Maximilian University of Munich, Institute of Social Paediatrics and Adolescent Medicine, Munich, Germany, Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Canada, Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, UK, Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan, Department of Family Medicine, Taipei City Hospital, ZhongXing Branch, Taipei, Taiwan and Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney, Australia.
authors: Yang-Ching
authors: YC
authors: Chen
authors: Ludwig Maximilian University of Munich, Institute of Social Paediatrics and Adolescent Medicine, Munich, Germany, Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Canada, Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, UK, Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan, Department of Family Medicine, Taipei City Hospital, ZhongXing Branch, Taipei, Taiwan and Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney, Australia.
authors: Bamini
authors: B
authors: Gopinath
authors: Ludwig Maximilian University of Munich, Institute of Social Paediatrics and Adolescent Medicine, Munich, Germany, Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Canada, Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, UK, Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan, Department of Family Medicine, Taipei City Hospital, ZhongXing Branch, Taipei, Taiwan and Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney, Australia.
authors: Stephanie
authors: S
authors: Ziebarth
authors: Ludwig Maximilian University of Munich, Institute of Social Paediatrics and Adolescent Medicine, Munich, Germany, Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Canada, Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, UK, Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan, Department of Family Medicine, Taipei City Hospital, ZhongXing Branch, Taipei, Taiwan and Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney, Australia.
authors: Rüdiger
authors: R
authors: von Kries
mesh_terms: D000293:Adolescent; D001724:Birth Weight; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008425:Maternal Behavior; D008875:Middle Aged; D016017:Odds Ratio; D010290:Parents; D010332:Paternal Behavior; D063766:Pediatric Obesity / Q000209:etiology* / Q000517:prevention & control; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*; D011795:Surveys and Questionnaires; D014028:Tobacco Smoke Pollution / Q000009:adverse effects* / Q000706:statistics & numerical data
chemical_list: D014028:Tobacco Smoke Pollution
keywords: Maternal smoking; household smoking; meta-analysis; obesity; overweight; paternal smoking