title: Membranous replication factories induced by plus-strand RNA viruses.
abstract: In this review, we summarize the current knowledge about the membranous replication factories of members of plus-strand (+) RNA viruses. We discuss primarily the architecture of these complex membrane rearrangements, because this topic emerged in the last few years as electron tomography has become more widely available. A general denominator is that two "morphotypes" of membrane alterations can be found that are exemplified by flaviviruses and hepaciviruses: membrane invaginations towards the lumen of the endoplasmatic reticulum (ER) and double membrane vesicles, representing extrusions also originating from the ER, respectively. We hypothesize that either morphotype might reflect common pathways and principles that are used by these viruses to form their membranous replication compartments.
authors: Department of Infectious Diseases, Molecular Virology, Heidelberg University, Im Neuenheimer Feld 345, 69120 Heidelberg, Germany. ines_romero-brey@med.uni-heidelberg.de.
authors: Inés
authors: I
authors: Romero-Brey
authors: Department of Infectious Diseases, Molecular Virology, Heidelberg University, Im Neuenheimer Feld 345, 69120 Heidelberg, Germany. ralf_bartenschlager@med.uni-heidelberg.de.
authors: Ralf
authors: R
authors: Bartenschlager
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000648:ultrastructure* / Q000821:virology; D003332:Coronaviridae / Q000145:classification / Q000502:physiology / Q000648:ultrastructure; D055032:Electron Microscope Tomography; D004721:Endoplasmic Reticulum / Q000648:ultrastructure* / Q000821:virology; D005057:Eukaryotic Cells / Q000473:pathology / Q000821:virology*; D018067:Flaviviridae / Q000145:classification / Q000502:physiology / Q000648:ultrastructure; D016174:Hepacivirus / Q000145:classification / Q000502:physiology / Q000648:ultrastructure; D006801:Humans; D010802:Phylogeny; D010849:Picornaviridae / Q000145:classification / Q000502:physiology / Q000648:ultrastructure; D014764:Viral Proteins / Q000737:chemistry* / Q000378:metabolism; D014779:Virus Replication / Q000502:physiology*
chemical_list: D014764:Viral Proteins