title: Impact of antepartum anemia on the development of chorioamnionitis at term.
abstract: OBJECTIVE
  The aim of this study is to assess the association of antepartum anemia with chorioamnionitis at term.
  
  
  METHODS
  This is a case control study of women with and without chorioamnionitis who delivered following spontaneous or induced labor at ≥ 37 weeks' gestation. Cases had both intrapartum fever ≥ 38°C and histologic chorioamnionitis. Controls were afebrile and matched by physician practice group. Anemia was defined by CDC guidelines as hemoglobin < 10.5 g/dL (second trimester) or < 11.0 g/dL (third trimester).
  
  
  RESULTS
  A total of 101 cases and 197 controls were identified. The prevalence of anemia at the second and third trimester complete blood count (CBC) was significantly higher in the chorioamnionitis group (p = 0.02). This association persisted after multiple logistic regression controlling for known clinical risk factors (adjusted odds ratios, 2.47; range, 1.24-4.94).
  
  
  CONCLUSIONS
  Anemia at the time of the second and third trimester CBC was more prevalent among women who developed chorioamnionitis at term. Antepartum anemia may be a modifiable risk factor in the prevention of chorioamnionitis at term.
authors: Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut.
authors: Karen
authors: K
authors: Archabald
authors: Division of Research, Department of Obstetrics and Gynecology, Warren Alpert Medical School of Brown University, Women and Infants Hospital, Providence, Rhode Island.
authors: Vrishali
authors: V
authors: Lopes
authors: Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Warren Alpert Medical School of Brown University, Women and Infants Hospital, Providence, Rhode Island.
authors: Brenna
authors: B
authors: Anderson
mesh_terms: D000328:Adult; D000740:Anemia / Q000453:epidemiology*; D016022:Case-Control Studies; D002821:Chorioamnionitis / Q000453:epidemiology* / Q000473:pathology*; D005260:Female; D005865:Gestational Age; D006801:Humans; D016017:Odds Ratio; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000453:epidemiology*; D011264:Pregnancy Trimesters; D047929:Term Birth