title: Improved antibacterial behavior of titanium surface with torularhodin-polypyrrole film.
abstract: The problem of microorganisms attaching and proliferating on implants and medical devices surfaces is still attracting interest in developing research on different coatings based on antibacterial agents. The aim of this work is centered on modifying titanium (Ti) based implants surfaces through incorporation of a natural compound with antimicrobial effect, torularhodin (T), by means of a polypyrrole (PPy) film. This study tested the potential antimicrobial activity of the new coating against a range of standard bacterial strains: Escherichia coli, Staphylococcus aureus, Enterococcus faecalis, Bacillus subtilis and Pseudomonas aeruginosa. The morphology, physical and electrochemical properties of the synthesized films were assessed by SEM, AFM, UV-Vis, FTIR and cyclic voltammetry. In addition, biocompatibility of this new coating was evaluated using L929 mouse fibroblast cells. The results showed that PPy-torularhodin composite film acts as a corrosion protective coating with antibacterial activity and it has no harmful effect on cell viability.
authors: University POLITEHNICA of Bucharest, 1-7 Polizu, 011061 Bucharest, Romania.
authors: Camelia
authors: C
authors: Ungureanu
authors: University POLITEHNICA of Bucharest, 1-7 Polizu, 011061 Bucharest, Romania.
authors: Simona
authors: S
authors: Popescu
authors: University POLITEHNICA of Bucharest, 1-7 Polizu, 011061 Bucharest, Romania.
authors: Gabriela
authors: G
authors: Purcel
authors: "Cantacuzino" National Institute of Research-Development for Microbiology and Immunology, 103 Splaiul Independentei, Sector 5, 050096 Bucharest, Romania.
authors: Vlad
authors: V
authors: Tofan
authors: University POLITEHNICA of Bucharest, 1-7 Polizu, 011061 Bucharest, Romania; National Institute for Research and Development in Microtechnologies, 126A, Erou Iancu Nicolae Street, 077190 Bucharest, Romania.
authors: Marian
authors: M
authors: Popescu
authors: "Cantacuzino" National Institute of Research-Development for Microbiology and Immunology, 103 Splaiul Independentei, Sector 5, 050096 Bucharest, Romania.
authors: Aurora
authors: A
authors: Sălăgeanu
authors: University POLITEHNICA of Bucharest, 1-7 Polizu, 011061 Bucharest, Romania. Electronic address: c_pirvu@chim.pub.ro.
authors: Cristian
authors: C
authors: Pîrvu
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D001419:Bacteria / Q000187:drug effects; D002338:Carotenoids / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D051379:Mice; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D011758:Pyrroles / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; D011108:Polymers; D011758:Pyrroles; C067635:polypyrrole; D002338:Carotenoids; D014025:Titanium; C078923:torularhodin
keywords: Antimicrobial activity; Biomedical devices; Polypyrrole; Titanium; Torularhodin