title: Coordinated photomorphogenic UV-B signaling network captured by mathematical modeling.
abstract: Long-wavelength and low-fluence UV-B light is an informational signal known to induce photomorphogenic development in plants. Using the model plant Arabidopsis thaliana, a variety of factors involved in UV-B-specific signaling have been experimentally characterized over the past decade, including the UV-B light receptor UV resistance locus 8; the positive regulators constitutive photomorphogenesis 1 and elongated hypocotyl 5; and the negative regulators cullin4, repressor of UV-B photomorphogenesis 1 (RUP1), and RUP2. Individual genetic and molecular studies have revealed that these proteins function in either positive or negative regulatory capacities for the sufficient and balanced transduction of photomorphogenic UV-B signal. Less is known, however, regarding how these signaling events are systematically linked. In our study, we use a systems biology approach to investigate the dynamic behaviors and correlations of multiple signaling components involved in Arabidopsis UV-B-induced photomorphogenesis. We define a mathematical representation of photomorphogenic UV-B signaling at a temporal scale. Supplemented with experimental validation, our computational modeling demonstrates the functional interaction that occurs among different protein complexes in early and prolonged response to photomorphogenic UV-B.
authors: Peking-Yale Joint Center for Plant Molecular Genetics and Agro-Biotechnology, State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center for Life Sciences, College of Life Sciences, Peking University, Beijing 100871, China;Rice Research Institute, Sichuan Agricultural University, Chengdu, Sichuan 611130, China;
authors: Xinhao
authors: X
authors: Ouyang
authors: Peking-Yale Joint Center for Plant Molecular Genetics and Agro-Biotechnology, State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center for Life Sciences, College of Life Sciences, Peking University, Beijing 100871, China;
authors: Xi
authors: X
authors: Huang
authors: Beijing International Center for Mathematical Research, Peking University, Beijing 100871, China;
authors: Xiao
authors: X
authors: Jin
authors: Department of Computer Science and Engineering, Washington University in St. Louis, St. Louis, MO 63105; and.
authors: Zheng
authors: Z
authors: Chen
authors: Peking-Yale Joint Center for Plant Molecular Genetics and Agro-Biotechnology, State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center for Life Sciences, College of Life Sciences, Peking University, Beijing 100871, China;
authors: Panyu
authors: P
authors: Yang
authors: Beijing International Center for Mathematical Research, Peking University, Beijing 100871, China;
authors: Hao
authors: H
authors: Ge
authors: Rice Research Institute, Sichuan Agricultural University, Chengdu, Sichuan 611130, China;
authors: Shigui
authors: S
authors: Li
authors: Peking-Yale Joint Center for Plant Molecular Genetics and Agro-Biotechnology, State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center for Life Sciences, College of Life Sciences, Peking University, Beijing 100871, China;Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520-8104 xingwang.deng@yale.edu.
authors: Xing Wang
authors: XW
authors: Deng
mesh_terms: D017360:Arabidopsis / Q000254:growth & development / Q000378:metabolism* / Q000528:radiation effects*; D029681:Arabidopsis Proteins / Q000737:chemistry / Q000378:metabolism; D055537:Light Signal Transduction / Q000528:radiation effects*; D008954:Models, Biological; D009024:Morphogenesis / Q000528:radiation effects*; D011485:Protein Binding / Q000528:radiation effects; D011487:Protein Conformation; D014466:Ultraviolet Rays
chemical_list: D029681:Arabidopsis Proteins
keywords: light signaling; ordinary differential equation