title: Comparison ofin vitroandin vivophototoxicity tests with S-(-)-10,11-dihydroxyfarnesic acid methyl ester produced byBeauveria bassianaKACC46831.
abstract: Beauveria bassianais a fungi that is well-known for demonstrating a resistance to environmental change. To confirm whether S-(-)-10,11-dihydroxyfarnesic acid methyl ester (DHFAME) produced byBeauveria bassianaKACC46831 causes phototoxicity when used for cosmetic purposes due to its anti-tyrosinase activity, we conductedin vitroandin vivophototoxicity tests. There were no significant changes or damage observed in the compound-treated group with regards to skin phototoxicity, while 8-methoxypsoralen, which served as a positive control, induced toxic effects. Thein vitro3T3 neutral red uptake assay, an alternative assessment, was used for further confirmation of the phototoxicity. The results showed that DHFAME did not exhibit phototoxicity at the designated concentrations, with or without UV irradiation in the 3T3 cells. These results indicated that the methyl ester produced byBeauveria bassianaKACC46831 does not induce phototoxicity in the skin. Therefore, the results of the present study indicate that DHFAME shows potential for use as a cosmetic ingredient that does not cause skin phototoxicity.
authors: Department of Food Science and Biotechnology, Graduate School, Kyungpook National University, Daegu 702-701, Republic of Korea.
authors: Min-A
authors: MA
authors: Kim
authors: Department of Food Science and Biotechnology, Graduate School, Kyungpook National University, Daegu 702-701, Republic of Korea.
authors: Hyeong-U
authors: HU
authors: Son
authors: Mycoplus Company Ltd., Anyang 431-080, Republic of Korea.
authors: Cheol-Sik
authors: CS
authors: Yoon
authors: Department of Agricultural Biology, National Academy of Agricultural Science, Rural Development Agency, Suwon 441-707, Republic of Korea.
authors: Sung-Hee
authors: SH
authors: Nam
authors: Department of Agricultural Biology, National Academy of Agricultural Science, Rural Development Agency, Suwon 441-707, Republic of Korea.
authors: Young-Cheol
authors: YC
authors: Choi
authors: Department of Food Science and Biotechnology, Graduate School, Kyungpook National University, Daegu 702-701, Republic of Korea ; Food and Bio-Industry Research Institute, Kyungpook National University, Daegu 702-701, Republic of Korea.
authors: Sang-Han
authors: SH
authors: Lee
keywords: 3T3 neutral red uptake test; Beauveria bassiana; S-(−)-10,11-dihydroxyfarnesic acid methyl ester; cosmetic ingredient; phototoxicity