title: Hyaluronan/RHAMM interactions in mesenchymal tumor pathogenesis: role of growth factors.
abstract: Fibrosarcoma belongs to the sarcoma cancer group, which are spindle cell malignancies of mesenchymal origin, and owe their name to the predominant cell line that is present within the tumor. The extracellular matrix (ECM) is a complicated structure that surrounds and supports cells within tissues. Its main components are proteoglycans, collagens, glycoproteins, hyaluronan (HA), and several matrix-degrading enzymes. During cancer progression, significant changes can be observed in the structural and mechanical properties of ECM components. The ECM provides a physical scaffold to which tumor cells attach and migrate. Thus, it is required for key cellular events such as cell motility, adhesion, proliferation, invasion, and metastasis. Importantly, fibrosarcomas were shown to have a high content and turnover of ECM components including HA, proteoglycans, collagens, fibronectin, and laminin. In this review, we will focus on the HA component of fibrosarcoma ECM and critically discuss its role and involved mechanisms during fibrosarcoma pathogenesis.
authors: Laboratory of Anatomy-Histology-Embryology, School of Medicine, University of Crete, Heraklion, Greece.
authors: Katerina
authors: K
authors: Kouvidi
authors: Laboratory of Anatomy-Histology-Embryology, School of Medicine, University of Crete, Heraklion, Greece.
authors: Dragana
authors: D
authors: Nikitovic
authors: Laboratory of Anatomy-Histology-Embryology, School of Medicine, University of Crete, Heraklion, Greece.
authors: Aikaterini
authors: A
authors: Berdiaki
authors: Laboratory of Anatomy-Histology-Embryology, School of Medicine, University of Crete, Heraklion, Greece. Electronic address: tzanakak@med.uoc.gr.
authors: George N
authors: GN
authors: Tzanakakis
mesh_terms: D000818:Animals; D002465:Cell Movement; D018450:Disease Progression; D005109:Extracellular Matrix / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D005346:Fibroblast Growth Factors / Q000378:metabolism; D005354:Fibrosarcoma / Q000378:metabolism* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism*; D006820:Hyaluronic Acid / Q000737:chemistry*; D007249:Inflammation; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D051379:Mice; D009389:Neovascularization, Pathologic; D011485:Protein Binding; D011509:Proteoglycans / Q000378:metabolism; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000378:metabolism
chemical_list: D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D018960:Hyaluronan Receptors; D036341:Intercellular Signaling Peptides and Proteins; D011509:Proteoglycans; D016212:Transforming Growth Factor beta; C098946:hyaluronan-mediated motility receptor; D005346:Fibroblast Growth Factors; D007334:Insulin-Like Growth Factor I; D006820:Hyaluronic Acid
keywords: Extracellular matrix; Fibrosarcoma; Growth factors; Hyaluronan; Rhamm