title: Intranasal dopamine treatment reinstates object-place memory in aged rats.
abstract: Following oral or IV administration, dopamine (DA) cannot cross the blood-brain barrier to a significant extent, but can enter the brain when administered via the nasal passages. Intranasal administration of DA was shown to increase extracellular DA in the striatum, to have antidepressant action and to improve attention and working memory in rats. Here we show that aged (22-24 months old) rats are deficient in an object-place learning task, but that this learning/memory is intact and comparable with that of adult rats upon pre-trial administration of 0.3 mg/kg DA gel into the nasal passages. This result raises the possibility of the therapeutic application of intranasal DA treatment for age-related cognitive disorders.
authors: Department Neuropathology, Heinrich-Heine University Düsseldorf, Moorenstr. 5, Düsseldorf 40225, Germany. Electronic address: Svenja.Trossbach@uni-duesseldorf.de.
authors: S V
authors: SV
authors: Trossbach
authors: Center for Behavioral Neuroscience, Institute of Experimental Psychology, Heinrich-Heine University Düsseldorf, Universitätsstr. 1, Düsseldorf 40225, Germany. Electronic address: desouza@uni-duesseldorf.de.
authors: M A
authors: MA
authors: de Souza Silva
authors: Center for Behavioral Neuroscience, Institute of Experimental Psychology, Heinrich-Heine University Düsseldorf, Universitätsstr. 1, Düsseldorf 40225, Germany. Electronic address: jph@uni-duesseldorf.de.
authors: J P
authors: JP
authors: Huston
authors: Department Neuropathology, Heinrich-Heine University Düsseldorf, Moorenstr. 5, Düsseldorf 40225, Germany. Electronic address: ckorth@uni-duesseldorf.de.
authors: C
authors: C
authors: Korth
authors: M et P Pharma AG, 6376 Emmetten, Switzerland; Oceanographic Center, Nova Southeastern University, Fort Lauderdale, FL 33314, USA. Electronic address: cu.mattern@bluewin.ch.
authors: C
authors: C
authors: Mattern
mesh_terms: D000281:Administration, Intranasal; D000375:Aging; D000818:Animals; D004298:Dopamine / Q000008:administration & dosage*; D007858:Learning / Q000187:drug effects*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D021641:Recognition, Psychology / Q000187:drug effects*; D065852:Spatial Memory / Q000187:drug effects*
chemical_list: D004298:Dopamine
keywords: Aging; Dopamine; Memory; Nasal administration; Place learning; Spatial object recognition