title: Fucoidans from marine algae as potential matrix metalloproteinase inhibitors.
abstract: Matrix metalloproteinases are endopeptidases which belong to the group of metalloproteinases that contribute for the extracellular matrix degradation and several tissue remodeling processes. An imbalance in the regulation of these endopeptidases eventually leads to several severe pathological complications like cancers, cardiac, cartilage, and neurological-related diseases. Hence, inhibitory substances of metalloproteinases (MMPIs) could prove beneficial in the management of above specified pathological conditions. The available synthetic MMPIs that have been reported until now have few shortcomings, and thus many of them could not make to the final clinical trials. Hence, a growing interest among researchers on screening of MMPIs from different natural resources is evident and especially natural products from marine origin. As there has been an unparalleled contribution of several biologically active compounds from marine resources that have shown a profound applications in nutraceuticals, cosmeceuticals, and pharmaceuticals, we have attempted to discuss the various MMPIs from edible seaweeds.
authors: Marine Biochemistry Laboratory, Department of Chemistry, Pukyong National University, Busan, South Korea.
authors: Noel Vinay
authors: NV
authors: Thomas
authors: Department of Marine-bio Convergence Science, Specialized Graduate School Science and Technology Convergence, Marine Bioprocess Research Center, Pukyong National University, Busan, South Korea. Electronic address: sknkim@pknu.ac.kr.
authors: Se-Kwon
authors: SK
authors: Kim
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D044645:Fucus / Q000737:chemistry; D005685:Galactans / Q000494:pharmacology; D006801:Humans; D061965:Matrix Metalloproteinase Inhibitors / Q000627:therapeutic use; D015394:Molecular Structure; D000459:Phaeophyceae / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D005685:Galactans; D061965:Matrix Metalloproteinase Inhibitors; D011134:Polysaccharides; C007789:fucoidan
keywords: Cancer; Inflammation; Marine algae; Matrix metalloproteinases; Metastasis; Phlorotannins; Sulfated polysaccharides