title: A review on antiproliferative and apoptotic activities of natural honey.
abstract: Recent statistics revealed that cancer is one among the main reasons for death throughout the world. Several treatments are available but still there is no cure when it is detected at late stages. One of the treatment modes for cancer is chemotherapy which utilizes anticancer drugs in order to eradicate the cancer cells by apoptosis. Apoptosis is a programmed cell death through which body maintains homeostasis or kills cancer cells by utilizing its cell machinery. Recent researches have concluded that dietary agents have a putative role in instituting apoptosis of cancer cells. Honey, one of the victuals rich in antioxidants, has a long-standing exposure to humans and its role in cancer prevention and treatment is a topic of current interest. Various researchers have been experimenting honey against different cancers and provided valuable insights about the apoptosis induced by the honey. This review will highlight the recent findings of apoptotic mechanism involved in different cancer cells. Further it also reports antitumor activity of honey in some animal models. Hence it is high-time to initiate more preclinical trials as well as clinical experiments which would further add to the knowledge of anticancer nature of honey and also endorse honey as a potential candidate in the war against cancer.
authors: Saravana Kumar
authors: SK
authors: Jaganathan
authors: Arunpandian
authors: A
authors: Balaji
authors: Muthu Vignesh
authors: MV
authors: Vellayappan
authors: Manjesh Kumar
authors: MK
authors: Asokan
authors: Aruna Priyadharshni
authors: AP
authors: Subramanian
authors: Agnes Aruna
authors: AA
authors: John
authors: Eko
authors: E
authors: Supriyanto
authors: Saiful Izwan Abd
authors: SI
authors: Razak
authors: IJN-UTM Cardiovascular Engineering Centre, Faculty of Bioscience and Medical Engineering, University Teknologi Malaysia, Johor Bahru 81310, Malaysia. jaganathaniitkgp@gmail.com.
authors: Mohsen
authors: M
authors: Marvibaigi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects*; D001685:Biological Factors / Q000494:pharmacology* / Q000627:therapeutic use*; D049109:Cell Proliferation / Q000187:drug effects*; D006722:Honey; D006801:Humans
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D001685:Biological Factors