title: Hexacoordinate nickel(II)/(III) complexes that mimic the catalytic cycle of nickel superoxide dismutase.
abstract: A functional model complex of nickel superoxide dismutase (NiSOD) with a non-peptide ligand which mimics the full catalytic cycle of NiSOD is unknown. Similarly, it has not been fully elucidated whether NiSOD activity is a result of an outer- or inner-sphere electron-transfer mechanism. With this in mind, two octahedral nickel(II)/(III) complexes of a bis-tridentate N2 S donor carboxamide ligand, N-2-phenylthiophenyl-2'-pyridinecarboxamide (HL(Ph)), have been synthesized, structurally characterized, and their SOD activities examined. These complexes mimic the full catalytic cycle of NiSOD. Electrochemical experiments support an outer-sphere electron-transfer mechanism for their SOD activity.
authors: Department of Chemistry, National Institute of Technology Durgapur, Mahatma Gandhi Avenue, Durgapur 713 209 (WB) (India).
authors: Sudip K
authors: SK
authors: Chatterjee
authors: Ram Chandra
authors: RC
authors: Maji
authors: Suman Kumar
authors: SK
authors: Barman
authors: Marilyn M
authors: MM
authors: Olmstead
authors: Apurba K
authors: AK
authors: Patra
mesh_terms: D055162:Biocatalysis; D055664:Electrochemical Techniques; D008024:Ligands; D008958:Models, Molecular; D008968:Molecular Conformation; D009532:Nickel / Q000737:chemistry / Q000378:metabolism*; D009942:Organometallic Compounds / Q000737:chemistry / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000737:chemistry / Q000378:metabolism*
chemical_list: D008024:Ligands; D009942:Organometallic Compounds; D009532:Nickel; D013482:Superoxide Dismutase
keywords: X-ray diffraction; electrochemistry; enzyme models; nickel; outer-sphere electron transfer