title: Synthesis, spectral, structural analysis and biological evaluation of a new hydrogen-bonded charge-transfer complex: 2,3-dimethylquinoxalinium-p-toluenesulfonate.
abstract: Studies concentration on hydrogen-bonded charge-transfer complex formed on the reaction between basic 2,3-dimethylquinoxaline with p-toluenesulfonic acid. The crystal was characterized by IR, NMR, thermal and elemental analysis. The crystal structure was deduced by single crystal X-ray diffraction studies which indicated that cation and anion are linked through strong N(+)-H---O(-) type of hydrogen bond. The hydrogen bonded charge transfer crystal was screened for its pharmacology, such as Calf thymus DNA binding/cleavage, antioxidant properties. The results indicated that the compound could interact with DNA through intercalation and should have weak to moderate capacity of scavenging with DPPH. The high thermal stability is due to the molecular frame work through H-bonding interaction. The microbial activities of synthesised compound were examined against various bacteria and fungi species.
authors: Department of Chemistry, Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore 641 020, Tamil Nadu, India.
authors: Venkatesan
authors: V
authors: Murugesan
authors: Department of Chemistry, Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore 641 020, Tamil Nadu, India.
authors: Munusamy
authors: M
authors: Saravanabhavan
authors: Department of Chemistry, Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore 641 020, Tamil Nadu, India. Electronic address: mmsekar7@gmail.com.
authors: Marimuthu
authors: M
authors: Sekar
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry*; D001557:Benzenesulfonates / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D002417:Cattle; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D053837:DNA Cleavage; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006860:Hydrogen Bonding; D008968:Molecular Conformation; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D013696:Temperature; D014783:Viscosity
chemical_list: D000890:Anti-Infective Agents; D000975:Antioxidants; D001557:Benzenesulfonates; D011810:Quinoxalines; D004247:DNA; C427203:calf thymus DNA; C029501:4-toluenesulfonic acid
keywords: Antioxidant and antimicrobial activity; Charge transfer; Crystal structure; DNA interaction; TG–DTA