title: Effect of Yiqi Jianpi plus anticancer herbs on spleen deficiency in colorectal cancer and its anti-tumor role.
abstract: OBJECTIVE
  To observe the effect of Yiqi Jianpi plus anticancer herbs on spleen deficiency in colorectal cancer and its anti-tumor role.
  
  
  METHODS
  Human intestinal cancer cell HT29 xenograft of nude mice model was established. The expression of EGF, VEGF, gastric cancer tumor growth in mice were observed.
  
  
  RESULTS
  Protein kinase C expression in in the Yiqi Jianpi group and Yiqi Jianpi anti-tumor group was significantly better than the model group (P<0.01, P<0.05). There was significantly more apoptotic cells in Yiqi Jianpi anti-tumor group than Yiqi Jianpi group and model group (P<0.01). Epidermal growth factor and vascular endothelial growth factor expression in Yiqi Jianpi group was significantly lower than Yiqi Jianpi group and model group (P<0.05).
  
  
  CONCLUSIONS
  Tumor can inhibit the expression of PKC inhibition. Yiqi Jianpi and anticancer treatment can reduce this inhibition. Besides this treatment can also inhibit expression of tumor related genes such as epidermal growth factor and vascular endothelial growth factor.
authors: Department of Internal TCM Medicine, People Hospital Affiliated to Southern Medical University, Zhengzhou 450000, China.
authors: Li-Ran
authors: LR
authors: Fu
authors: Tumor Surgery Department, 2nd Affiliated Hospital of Henan Hospital of TCM, Zhengzhou 450000, China.
authors: Sheng-Wei
authors: SW
authors: Guo
authors: Tumor Surgery Department, 2nd Affiliated Hospital of Henan Hospital of TCM, Zhengzhou 450000, China.
authors: Xian-Hui
authors: XH
authors: Liu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D015179:Colorectal Neoplasms; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D019073:HT29 Cells; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D013154:Spleen / Q000187:drug effects*; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D004365:Drugs, Chinese Herbal
keywords: Anti-cancer treatment; Intestinal cancer; Spleen-qi deficiency; Yiqi Jianpi