title: Association between HTR7 genetic polymorphisms and alcohol dependence, using the alcohol use disorders identification test (AUDIT).
abstract: BACKGROUND
  A recent genome-wide association study has identified 5-hydroxytrytamine (serotonin) receptor 7, adenylate cyclase-coupled (HTR7) as a risk gene for alcohol dependence. In addition, the serotonergic system has been considered as a modulator that plays an important role in alcohol use disorders. Functional, pharmacological, and genetic studies of serotonin neurotransmission have revealed that serotonin receptors are potential targets for the treatment of alcohol use disorders. The aim of this study is to investigate whether associations between HTR7 genetic polymorphisms and alcohol dependence could be replicated.
  
  
  METHODS
  This study genotyped a total of 22 common single nucleotide polymorphisms (SNPs) in 459 alcoholic patients and 444 nonalcoholic controls.
  
  
  RESULTS
  Logistic regression analysis of the case-control study, controlling for age and sex as covariates, showed nominal associations of 7 SNPs (p = 0.02 to 0.04; odds ratio = 0.60 to 1.35). In further linear regression analysis based on the Alcohol Use Disorders Identification Test score for alcohol dependence, 8 SNPs and 3 haplotypes showed relatively significant associations with alcohol dependence (minimum p = 0.001; p(corr) = 0.02).
  
  
  CONCLUSIONS
  Although further replications and functional evaluations are needed, our findings suggest that genetic variations of HTR7 may contribute to the predisposition for alcohol dependence.
authors: Department of Life Science, Sogang University, Seoul, Korea; Research Institute for Basic Science, Sogang University, Seoul, Korea.
authors: Jeong-Hyun
authors: JH
authors: Kim
authors: Byung-Lae
authors: BL
authors: Park
authors: Hyun Sub
authors: HS
authors: Cheong
authors: Joon Seol
authors: JS
authors: Bae
authors: Lyoung Hyo
authors: LH
authors: Kim
authors: Jee Wook
authors: JW
authors: Kim
authors: Byoung Chul
authors: BC
authors: Lee
authors: Cheong Hoon
authors: CH
authors: Seo
authors: Tae-Cheon
authors: TC
authors: Kang
authors: Sun-Hee
authors: SH
authors: Park
authors: Ihn-Geun
authors: IG
authors: Choi
authors: Hyoung Doo
authors: HD
authors: Shin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000437:Alcoholism / Q000175:diagnosis* / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D055106:Genome-Wide Association Study / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011985:Receptors, Serotonin / Q000235:genetics*; D055815:Young Adult
chemical_list: D011985:Receptors, Serotonin; C104425:serotonin 7 receptor
keywords: Alcohol Dependence; Alcohol Use Disorders Identification Test; HTR7; Single Nucleotide Polymorphism