title: Interferon-γ-producing B cells induce the formation of gastric lymphoid follicles after Helicobacter suis infection.
abstract: Helicobacter (H.) suis is capable of infecting various animals including humans, and H. suis infections can lead to gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Recently, we reported that interferon-γ (IFN-γ) was highly expressed in the stomachs of H. suis-infected mice, but the direct relationship between the upregulation of IFN-γ expression and the formation of gastric lymphoid follicles after H. suis infection remains unclear. Here, we demonstrated that the IFN-γ produced by B cells plays an important role in the formation of gastric lymphoid follicles after H. suis infection. In addition, IFN-γ-producing B cells evoked gastric lymphoid follicle formation independent of T-cell help, suggesting that they are crucial for the development of gastric MALT induced by Helicobacter infection.
authors: Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
authors: L
authors: L
authors: Yang
authors: Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
authors: K
authors: K
authors: Yamamoto
authors: Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
authors: S
authors: S
authors: Nishiumi
authors: Graduate School of Pharmaceutical Science, Kitasato University, Minato-ku, Tokyo, Japan.
authors: M
authors: M
authors: Nakamura
authors: Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Minato-ku, Tokyo, Japan.
authors: H
authors: H
authors: Matsui
authors: Third Department of Internal Medicine, Kyorin University, Tokyo, Japan.
authors: S
authors: S
authors: Takahashi
authors: Department of Gastroenterology, Research Center for Hepatitis and Immunology, Research Institute, National Center for Global Health and Medicine, Ichikawa, Japan.
authors: T
authors: T
authors: Dohi
authors: Department of Gastroenterology, Research Center for Hepatitis and Immunology, Research Institute, National Center for Global Health and Medicine, Ichikawa, Japan.
authors: T
authors: T
authors: Okada
authors: Department of Gastroenterology, Research Center for Hepatitis and Immunology, Research Institute, National Center for Global Health and Medicine, Ichikawa, Japan.
authors: K
authors: K
authors: Kakimoto
authors: Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
authors: N
authors: N
authors: Hoshi
authors: 1] Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan [2] The Integrated Center for Mass Spectrometry, Graduate School of Medicine, Kobe University, Kobe, Japan [3] Division of Metabolomics Research, Kobe University Graduate School of Medicine, Kobe, Japan.
authors: M
authors: M
authors: Yoshida
authors: Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
authors: T
authors: T
authors: Azuma
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D054382:Chemokine CXCL13 / Q000235:genetics / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D005753:Gastric Mucosa / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology; D005756:Gastritis / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D005786:Gene Expression Regulation; D016481:Helicobacter Infections / Q000276:immunology* / Q000378:metabolism* / Q000382:microbiology; D018247:Helicobacter heilmannii / Q000276:immunology*; D007371:Interferon-gamma / Q000096:biosynthesis* / Q000235:genetics; D051379:Mice; D018345:Mice, Knockout; D013270:Stomach / Q000276:immunology* / Q000382:microbiology
chemical_list: D054382:Chemokine CXCL13; D007371:Interferon-gamma