title: Nonclassical T cells and their antigens in tuberculosis.
abstract: T cells that recognize nonpeptidic antigens, and thereby are identified as nonclassical, represent important yet poorly characterized effectors of the immune response. They are present in large numbers in circulating blood and tissues and are as abundant as T cells recognizing peptide antigens. Nonclassical T cells exert multiple functions including immunoregulation, tumor control, and protection against infections. They recognize complexes of nonpeptidic antigens such as lipid and glycolipid molecules, vitamin B2 precursors, and phosphorylated metabolites of the mevalonate pathway. Each of these antigens is presented by antigen-presenting molecules other than major histocompatibility complex (MHC), including CD1, MHC class I-related molecule 1 (MR1), and butyrophilin 3A1 (BTN3A1) molecules. Here, we discuss how nonclassical T cells participate in the recognition of mycobacterial antigens and in the mycobacterial-specific immune response.
authors: SIgN (Singapore Immunology Network), A*STAR (Agency for Science, Technology and Research), 138648 Singapore Experimental Immunology, Department of Biomedicine, University Hospital Basel, CH-4031 Basel, Switzerland.
authors: Gennaro
authors: G
authors: De Libero
authors: SIgN (Singapore Immunology Network), A*STAR (Agency for Science, Technology and Research), 138648 Singapore.
authors: Amit
authors: A
authors: Singhal
authors: Experimental Immunology, Department of Biomedicine, University Hospital Basel, CH-4031 Basel, Switzerland.
authors: Marco
authors: M
authors: Lepore
authors: SIgN (Singapore Immunology Network), A*STAR (Agency for Science, Technology and Research), 138648 Singapore Experimental Immunology, Department of Biomedicine, University Hospital Basel, CH-4031 Basel, Switzerland.
authors: Lucia
authors: L
authors: Mori
mesh_terms: D017951:Antigen Presentation / Q000276:immunology*; D000941:Antigens / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D013601:T-Lymphocytes / Q000276:immunology*; D014376:Tuberculosis / Q000276:immunology*
chemical_list: D000941:Antigens