title: Long-term use of ciclosporin on kidney transplant recipients surviving more than 10 years.
abstract: OBJECTIVE
  To evaluate the long-term use of ciclosporin on kidney transplant recipients who survived more than 10 years.
  
  
  METHODS
  We reviewed cadaveric kidney transplant patients who had survived 10 years or longer in this study. Patients were divided into five groups based on their ciclosporin concentration at one year: group 1 (> 250 ng/ml), group 2 (200-250 ng/ml), group 3 (150-200 ng/ml), group 4 100-150 ng/ml) and group 5 (< 100 ng/ml). Lab parameters were compared among these groups over time.
  
  
  RESULTS
  There were no differences in lab parameters among the five groups. At five years, systolic blood pressures (SBP), TG, CH, DB, TB were significantly higher in groups 3, 4, and 5. Uric acid was also higher but albumin was lower in group 5 compared to those in all other groups. Prevalence of proteinuria in both groups 4 and 5 were lower. At 10 years, SBP in group 3 was lower while both uric acid and ALT in all groups were decreased.
  
  
  CONCLUSIONS
  In patients who survived for more than 10 years after kidney transplantation, serum lipid levels were markedly elevated, indicating the increase of cardiovascular risk factors for patients, which might impact long-term survival benefit.
authors: Yan
authors: Y
authors: Qin
authors: Yu
authors: Y
authors: Fan
authors: XingYu
authors: X
authors: Mu
authors: Fang
authors: F
authors: Zhang
authors: Bing
authors: B
authors: Shen
authors: Yong
authors: Y
authors: Liu
authors: YiFeng
authors: Y
authors: Guo
authors: Yong
authors: Y
authors: Wang
authors: Jianxin
authors: J
authors: Qiu
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D001772:Blood Cell Count; D001774:Blood Chemical Analysis; D016572:Cyclosporine / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007668:Kidney / Q000502:physiology; D007677:Kidney Function Tests; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents; D016572:Cyclosporine