title: Antihyperlipidemic and hepatoprotective activities of mycelia zinc polysaccharide from Pholiota nameko SW-02.
abstract: The objective of this study was to set up the mice hyperlipidemic model to observe the pharmacological effects of mycelia zinc polysaccharide (MZPS) of Pholiota nameko SW-02 on lipid metabolism and oxidative stress. IR spectrum of MZPS showed typical structure of fungi polysaccharides. The zinc content, determined by flame atomic absorption spectrometry, was 16.68±0.73 mg/g. By the analysis of GC and HPGPC, the MZPS was composed of glucose, mannose, galactose and arabinose, and the weight-average molecular weight was 3.64×10(4) Da. The model of hyperlipidemic mice was established by perfusion high-fat emulsion, which caused hyperlipidemia and an increase in oxidative stress. The results showed that the supplementation of MZPS could improve blood lipid levels (TC, TG, HDL-C, LDL-C and VLDL-C), liver lipid levels (TC and TG) and antioxidant status (SOD, T-AOC, MDA and LPO). In addition, the histopathological observations of mice livers and the glutamate pyruvate transaminase activities indicated that the MZPS could attenuate liver cell injury. These results demonstrated that the MZPS might be effective in lowering lipid and protecting against high-fat diet-induced hyperlipidemia and non-alcoholic fatty liver.
authors: College of Life Science, Shandong Agricultural University, Taian, Shandong 271018, PR China.
authors: Lan
authors: L
authors: Zheng
authors: College of Life Science, Shandong Agricultural University, Taian, Shandong 271018, PR China.
authors: Guoyin
authors: G
authors: Zhai
authors: College of Life Science, Shandong Agricultural University, Taian, Shandong 271018, PR China.
authors: Jianjun
authors: J
authors: Zhang
authors: College of Life Science, Shandong Agricultural University, Taian, Shandong 271018, PR China.
authors: Liqin
authors: L
authors: Wang
authors: College of Life Science, Shandong Agricultural University, Taian, Shandong 271018, PR China.
authors: Zhao
authors: Z
authors: Ma
authors: The Second High School of Taian, Taian, Shandong 271000, PR China.
authors: Mengshi
authors: M
authors: Jia
authors: College of Life Science, Shandong Agricultural University, Taian, Shandong 271018, PR China. Electronic address: ourlaboratory@163.com.
authors: Le
authors: L
authors: Jia
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D062610:Fungal Polysaccharides / Q000737:chemistry* / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000737:chemistry* / Q000494:pharmacology; D050356:Lipid Metabolism / Q000187:drug effects; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D051379:Mice; D008970:Molecular Weight; D025282:Mycelium / Q000737:chemistry*; D055368:Pholiota / Q000737:chemistry*; D020011:Protective Agents / Q000737:chemistry* / Q000494:pharmacology; D015032:Zinc / Q000737:chemistry*
chemical_list: D062610:Fungal Polysaccharides; D000960:Hypolipidemic Agents; D008055:Lipids; D020011:Protective Agents; D015032:Zinc
keywords: Antihyperlipidemic activity; Mycelia zinc polysaccharide; Pholiota nameko SW-02