title: Large-cell neuroendocrine carcinoma of the lung: surgical management.
abstract: Large-cell neuroendocrine carcinoma (LCNEC) of the lung is an uncommon aggressive neoplasm with a poor prognosis compared with non-small-cell lung carcinoma (NSCLC). Because of its rarity, the treatment recommendations are not based on clinical trials, but are extrapolated from the approach to patients with NSCLC and small-cell lung carcinoma and the established literature for LCNEC, which is primarily retrospective in nature. Further studies should clarify the histology-specific characteristic and optimal therapeutic approach to establish the entity of LCNEC.
authors: Division of Thoracic Surgery, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. Electronic address: hsakurai@ncc.go.jp.
authors: Hiroyuki
authors: H
authors: Sakurai
authors: Division of Thoracic Surgery, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
authors: Hisao
authors: H
authors: Asamura
mesh_terms: D018287:Carcinoma, Large Cell / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D018278:Carcinoma, Neuroendocrine / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000601:surgery; D008175:Lung Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D011859:Radiography; D012189:Retrospective Studies; D015996:Survival Rate
keywords: Large-cell neuroendocrine carcinoma; Non–small-cell lung cancer; Prognosis