title: The nutritional status and factors contributing to malnutrition in children with chronic pancreatitis.
abstract: OBJECTIVE
  The present study was undertaken to determine the prevalence of malnutrition among children with chronic pancreatitis (CP). Furthermore, we aimed to evaluate the relationship between etiological factors of CP, its clinical characteristics, and the severity of malnutrition.
  
  
  METHODS
  The study included 208 children with CP (113 girls and 95 boys; mean age: 10.8 years, range: 1.6-18 years), hospitalized at our center between 1988 and 2012. The severity of malnutrition was graded on the basis of Cole's ratios, and its prevalence was analyzed according to the etiological factors of pancreatitis. Moreover, the analysis of discrimination was performed to identify the factors contributing to malnutrition among the following variables: age at CP onset, duration of CP, number of CP exacerbations, the number of ERCPs performed, the grade of pancreatic damage documented on imaging, co-occurrence of diabetes, and the results of 72-h fecal fat quantification.
  
  
  RESULTS
  We documented features of malnutrition in 52 (25%) children with CP, including 36 (17.3%) patients with moderate malnutrition, and 2 (0.96%) with severe malnutrition. There was no significant difference in the prevalence of malnutrition between groups of patients with various etiological factors of chronic pancreatitis. The age at CP onset showed the best discrimination ability of malnourished patients: the mean age at disease onset in a subgroup of malnourished children was significantly higher than in children with Cole's index >85%.
  
  
  CONCLUSIONS
  A considerable percentage of children with CP can suffer from clinically significant malnutrition. Later age at CP onset predisposes to development of malnutrition.
authors: Department of Gastroenterology, Hepatology and Feeding Disorders, The Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland.
authors: E
authors: E
authors: Kolodziejczyk
authors: Department of Gastroenterology, Hepatology and Feeding Disorders, The Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland.
authors: K
authors: K
authors: Wejnarska
authors: Department of Gastroenterology, Hepatology and Feeding Disorders, The Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland.
authors: M
authors: M
authors: Dadalski
authors: Department of Gastroenterology, Hepatology and Feeding Disorders, The Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland. Electronic address: j.kierkus@czd.pl.
authors: J
authors: J
authors: Kierkus
authors: Department of Gastroenterology, Hepatology and Feeding Disorders, The Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland.
authors: J
authors: J
authors: Ryzko
authors: Department of Gastroenterology, Hepatology and Feeding Disorders, The Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland.
authors: G
authors: G
authors: Oracz
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D002648:Child; D002675:Child, Preschool; D002760:Cholangiopancreatography, Endoscopic Retrograde; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D044342:Malnutrition / Q000453:epidemiology / Q000209:etiology*; D009752:Nutritional Status; D050500:Pancreatitis, Chronic / Q000150:complications* / Q000453:epidemiology / Q000235:genetics; D015995:Prevalence
keywords: Children; Chronic; Cole's index; Exocrine pancreatic insufficiency; Malnutrition; Pancreatits