title: Mimicking caloric restriction: what about macronutrient manipulation? A response to Meynet and Ricci.
abstract: As ongoing research continues to reveal the links between metabolism, cancer, and aging it is good to see non-toxic interventions such as caloric restriction (CR) coming into focus. Recently, Meynet and Ricci provided a timely review summarizing the current state of research on the possible role of CR in cancer treatment. In discussing ways to implement clinically the beneficial effects of CR without a need for overall reduced food intake these authors focused on CR-mimicking drugs that have several limitations. I propose carbohydrate restriction as probably the best way to mimic CR in humans without the need to restrict energy intake.
authors: Department of Radiotherapy and Radiation Oncology, Leopoldina Hospital, 97421 Schweinfurt, Germany. Electronic address: rainer_klement@gmx.de.
authors: Rainer J
authors: RJ
authors: Klement
mesh_terms: D000818:Animals; D031204:Caloric Restriction; D006801:Humans; D009369:Neoplasms / Q000178:diet therapy* / Q000378:metabolism*
keywords: caloric restriction; cancer; carbohydrate-restricted; diet; ketogenic diet; protein-restricted