title: Metal-free oxidative olefination of primary amines with benzylic C-H bonds through direct deamination and C-H bond activation.
abstract: An oxidative olefination reaction between aliphatic primary amines and benzylic sp(3) C-H bonds has been achieved using N-bromosuccinimide as catalyst and tert-butyl hydroperoxide as oxidant. The olefination proceeds under mild metal-free conditions through direct deamination and benzylic C-H bond activation, and provides easy access to biologically active 2-styrylquinolines with (E)-configuration.
authors: State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, 300071, China. wangbin@nankai.edu.cn.
authors: Liang
authors: L
authors: Gong
authors: Li-Juan
authors: LJ
authors: Xing
authors: Tong
authors: T
authors: Xu
authors: Xue-Ping
authors: XP
authors: Zhu
authors: Wen
authors: W
authors: Zhou
authors: Ning
authors: N
authors: Kang
authors: Bin
authors: B
authors: Wang
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D001974:Bromosuccinimide / Q000737:chemistry; D002384:Catalysis; D003641:Deamination; D016877:Oxidants / Q000737:chemistry*; D010084:Oxidation-Reduction; D011804:Quinolines / Q000138:chemical synthesis*; D020122:tert-Butylhydroperoxide / Q000737:chemistry*
chemical_list: D000475:Alkenes; D000588:Amines; D016877:Oxidants; D011804:Quinolines; D020122:tert-Butylhydroperoxide; D001974:Bromosuccinimide