title: Hemostatic agents used for nephrostomy tract closure after tubeless PCNL: a systematic review and meta-analysis.
abstract: To evaluate the role of hemostatic agents used for nephrostomy tract closure after tubeless percutaneous nephrolithotomy (PCNL). A systematic review of Pubmed, Embase and Cochrane was performed. All studies that compared hemostatic agents with common methods (silk stitch or pressure dressing) were included. The analyzed outcomes were hospital stay, operative time, blood loss, transfusion rate, fever rate, and complication rate. A total of eight articles including six RCTs met our criteria. Hemostatic agents showed short hospital stay (MD -4.54, 95 % CI -6.78 to -2.36, p < 0.0001). There was no difference between hemostatic agents and common methods on operative time (MD 2.00, 95 % CI -17.32 to 21.33, p = 0.84), blood loss (MD -0.19, 95 % CI -0.41 to 0.03, p = 0.08), transfusion rate (OR 1.42, 95 % CI 0.34-5.96, p = 0.63), fever rate (OR 1.02, 95 % CI 0.33-3.12, p = 0.97) and complication rate (OR 1.02, 95 % CI 0.33-3.12, p = 0.97). Eight studies including six RCTs showed that use of hemostatic agents was safe. Hemostatic agents showed short hospital stay. There were no difference between hemostatic agents and common methods on blood loss, transfusion rate, fever rate, and complication rate.
authors: Department of Urology, Xiangya Hospital, Central South University, Changsha, 410000, Hunan, China.
authors: Cui
authors: C
authors: Yu
authors: Zhou
authors: Z
authors: Xu
authors: Wang
authors: W
authors: Long
authors: Liu
authors: L
authors: Longfei
authors: Zeng
authors: Z
authors: Feng
authors: Qi
authors: Q
authors: Lin
authors: Zu
authors: Z
authors: Xiongbing
authors: Chen
authors: C
authors: Hequn
mesh_terms: D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D009403:Nephrostomy, Percutaneous / Q000379:methods*; D058106:Wound Closure Techniques
chemical_list: D006490:Hemostatics