title: Sleep disorders of Whipple's disease of the brain.
abstract: OBJECTIVE
  To understand the effects of Whipple's disease (WD) of the brain on sleep function.
  
  
  METHODS
  Clinical and polysomnographic studies of two patients with severe disruption of sleep due to WD: a 48-year-old female with primary WD of the brain and a 41-year-old male with secondary WD of the brain.
  
  
  RESULTS
  The patient with primary WD had hypersomnolence with severe obstructive sleep apnoea, reduced sleep efficiency, frequent waking and sleep fragmentation. The patient with secondary WD was also hypersomnolent with oculomastictory myorhythmia. He was shown to have severe sleep initiation insomnia with poor sleep efficiency, severe obstructive sleep apnoea/hypopnoea and oculomasticatory myorhythmia at sleep-wake transitions.
  
  
  CONCLUSIONS
  WD of the brain may affect sleep biology in its primary and secondary forms leading to hypersomnolence from obstructive sleep apnoea, sleep fragmentation, reduced sleep efficiency, sleep initiation insomnia and intrusive oculomasticatory myorhythmia.
authors: From the Neurodegenerative Disorders Research Pty Ltd, 4 Lawrence Avenue, West Perth, Western Australia 6005 research@ndr.org.au.
authors: P K
authors: PK
authors: Panegyres
authors: From the Neurodegenerative Disorders Research Pty Ltd, 4 Lawrence Avenue, West Perth, Western Australia 6005.
authors: J
authors: J
authors: Goh
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology*; D006970:Disorders of Excessive Somnolence; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020181:Sleep Apnea, Obstructive; D007319:Sleep Initiation and Maintenance Disorders; D008061:Whipple Disease / Q000150:complications*