title: Y-box binding protein 1 expression in gastric cancer subtypes and association with cancer neovasculature.
abstract: OBJECTIVE
  Y-box binding protein 1 (YB-1) expression in cancer cells is closely associated with malignant progression and poor prognosis in various cancers. Recently, we demonstrated that YB-1 expression in cancer cells is an immunomarker for patient prognosis and liver metastasis of gastric cancer (GC), and identified YB-1 as an excellent biomarker of angiogenic and proliferating endothelial cells in cancers. We further explored the expression patterns of YB-1 in gastric vasculature and the relationship with the clinical pathologic characteristics, as well as YB-1 phenotype in cancer cells.
  
  
  METHODS
  Immunohistochemical analysis of YB-1 was performed using 163 surgically resected primary GC specimens.
  
  
  RESULTS
  YB-1 expression in cancer cells significantly differed with respect to Lauren type, JGCA classification, vascular invasion (VI), and microvessel density (MVD) of cancers (P = 0.018, P = 0.002, P < 0.001, and P < 0.001, respectively). No correlation was found between cancer-cell YB-1 expression and TNM stage or lymphatic invasion. However, YB-1 expression in vascular endothelial cells significantly correlated with N stage, M stage, TNM stage, and MVD of cancers (P < 0.001, P = 0.013, P < 0.001, and P < 0.001, respectively). Notably, cases with YB-1 expression in cancer vasculature also demonstrated YB-1 expression in cancer cells (P = 0.040).
  
  
  CONCLUSIONS
  YB-1 may promote GC development through its function in both cancer cells and cancer vascular cells, and thus represent a potential biomarker in this disease.
authors: Department of General Practice, The First Hospital, China Medical University, Shenyang, China.
authors: Y
authors: Y
authors: Wu
authors: K-Y
authors: KY
authors: Wang
authors: Z
authors: Z
authors: Li
authors: Y-P
authors: YP
authors: Liu
authors: H
authors: H
authors: Izumi
authors: S
authors: S
authors: Yamada
authors: H
authors: H
authors: Uramoto
authors: Y
authors: Y
authors: Nakayama
authors: K
authors: K
authors: Ito
authors: K
authors: K
authors: Kohno
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D018279:Carcinoma, Signet Ring Cell / Q000098:blood supply / Q000378:metabolism / Q000556:secondary*; D018450:Disease Progression; D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D013274:Stomach Neoplasms / Q000098:blood supply / Q000145:classification* / Q000378:metabolism / Q000473:pathology*; D051840:Y-Box-Binding Protein 1 / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D051840:Y-Box-Binding Protein 1