title: Antithrombotic reversal agents.
abstract: The actively bleeding anticoagulated patient presenting to the emergency department requires rapid evaluation and treatment, which is made increasingly complicated by the ever-evolving antithrombotic treatment options used in medicine. Even with excellent supportive care, the timeliness with which reversal decisions need to be made continues to demand of the emergency practitioner a familiarity with the properties and general characteristics of a variety of antithrombotic agents. Reversal options vary and may include vitamin K, FFP, PCC, rFVIIa, platelets, and desmopressin, among others.
authors: Department of Emergency Medicine, Georgetown University Hospital, Washington Hospital Center, 110 Irving Street, NA 1177, Washington, DC 20010, USA.
authors: Matthew D
authors: MD
authors: Wilson
authors: Department of Emergency Medicine, Georgetown University Hospital, Washington Hospital Center, 110 Irving Street, NA 1177, Washington, DC 20010, USA. Electronic address: jdthere@gmail.com.
authors: Jonathan E
authors: JE
authors: Davis
mesh_terms: D000933:Antifibrinolytic Agents / Q000627:therapeutic use*; D001779:Blood Coagulation Factors / Q000627:therapeutic use; D004636:Emergency Service, Hospital; D005343:Fibrinolytic Agents / Q000009:adverse effects*; D006470:Hemorrhage / Q000188:drug therapy* / Q000209:etiology; D006487:Hemostasis / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D014812:Vitamin K / Q000627:therapeutic use
chemical_list: D000933:Antifibrinolytic Agents; D001779:Blood Coagulation Factors; D005343:Fibrinolytic Agents; D014812:Vitamin K; C025667:prothrombin complex concentrates
keywords: Anticoagulate; Antithrombotic reversal agent; Bleeding; Coagulopathic; Emergency department; Reversal options