title: Increased nucleated red blood cells counts in prolonged rupture of membranes is not erythropoietin driven.
abstract: OBJECTIVE
  The aim of this study is to examine the hypothesis that prolonged rupture of membranes (PROM) is associated with increased cord blood erythropoietin (EPO) concentrations, proportional to the duration of ruptured membranes.
  
  
  METHODS
  This study is a prospective, cross-sectional, observational (noninterventional) cohort study of mother-infant pairs. Criteria for inclusion were as follows: active labor with or without ruptured membranes and vaginally delivered neonates. Excluded were infants with major factors known to be associated with a potential increase in fetal erythropoiesis.
  
  
  RESULTS
  A total of 40 mother-infant pairs were recruited. EPO was not influenced by duration of ruptured membranes and significantly correlated only with maternal body mass index.
  
  
  CONCLUSIONS
  Cord blood concentrations of EPO do not appear to be significantly affected by the duration of ruptured membranes. We speculate that erythropoiesis is upregulated in PROM by mechanisms that involve the production of cytokines and are not EPO driven.
authors: Departments of Obstetrics and Gynecology, The Lis Maternity Hospital and the Dana Duek Children's Hospital, The Tel Aviv Medical Center, Tel Aviv, Israel.
authors: Sarit
authors: S
authors: Barak
authors: Departments of Pediatrics, The Lis Maternity Hospital and the Dana Duek Childrens Hospital, The Tel Aviv Medical Center, Tel Aviv, Israel.
authors: Francis B
authors: FB
authors: Mimouni
authors: Departments of Hematology, The Lis Maternity Hospital and the Dana Duek Childrens Hospital, The Tel Aviv Medical Center, Tel Aviv, Israel.
authors: Ruth
authors: R
authors: Stern
authors: Departments of Neonatology, The Lis Maternity Hospital and the Dana Duek Childrens Hospital, The Tel Aviv Medical Center, Tel Aviv, Israel.
authors: Neta
authors: N
authors: Cohen
authors: Departments of Obstetrics and Gynecology, The Lis Maternity Hospital and the Dana Duek Children's Hospital, The Tel Aviv Medical Center, Tel Aviv, Israel.
authors: Dana Barbing
authors: DB
authors: Goldstein
authors: Departments of Neonatology, The Lis Maternity Hospital and the Dana Duek Childrens Hospital, The Tel Aviv Medical Center, Tel Aviv, Israel.
authors: Ronella
authors: R
authors: Marom
mesh_terms: D000328:Adult; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D004906:Erythrocyte Count; D004921:Erythropoietin / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005322:Premature Rupture of Fetal Membranes / Q000097:blood*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D004921:Erythropoietin