title: Mapping of ApoE4 Related White Matter Damage using Diffusion MRI.
abstract: ApoliopoproteinEε4 (ApoE-ε4) polymorphism is the most well known genetic risk factor for developing Alzheimers Disease. The exact mechanism through which ApoEε4 increases AD risk is not fully known, but may be related to decreased clearance and increased oligomerization of Aβ. By making measurements of white matter integrity via diffusion MR and correlating the metrics in a voxel-based statistical analysis with ApoE-ε4 genotype (whilst controlling for vascular risk factor, gender, cognitive status and age) we are able to identify changes in white matter associated with carrying an ApoEε4 allele. We found potentially significant regions (Puncorrected< 0.05) near the hippocampus and the posterior cingulum that were independent of voxels that correlated with age or clinical dementia rating (CDR) status suggesting that ApoE may affect cognitive decline via a pathway in dependent of normal aging and acute insults that can be measured by CDR and Framingham Coronary Risk Score (FCRS).
authors: University of Washington, Seattle, Washington, USA.
authors: Sinchai
authors: S
authors: Tsao
authors: University of Southern California, Los Angeles, California, USA ; Children's Hospital Los Angeles, Los Angeles, California, USA.
authors: Niharika
authors: N
authors: Gajawelli
authors: University of Southern California, Los Angeles, California, USA.
authors: Darryl Hwa
authors: DH
authors: Hwang
authors: Center for Neurodegenerative Disease, San Francisco VA Medical Center San Francisco, California, USA.
authors: Stephen
authors: S
authors: Kriger
authors: University of Southern California, Los Angeles, California, USA.
authors: Meng
authors: M
authors: Law
authors: University of Southern California, Los Angeles, California, USA.
authors: Helena
authors: H
authors: Chui
authors: Center for Neurodegenerative Disease, San Francisco VA Medical Center San Francisco, California, USA.
authors: Michael
authors: M
authors: Weiner
authors: University of Southern California, Los Angeles, California, USA ; Children's Hospital Los Angeles, Los Angeles, California, USA.
authors: Natasha
authors: N
authors: Lepore
keywords: Alzheimer’s Disease; ApoE; DTI; Dementia; Diffusion MRI; MRI; Neuroimaging