title: Silent diabetes mellitus, periodontitis and a new case of thalamic abscess.
abstract: Brain abscess is an unusual complication of uncontrolled diabetes. A solitary thalamic abscess is an uncommon type of brain abscess. We report a case of thalamic abscess, whereupon diabetes mellitus and periodontitis were diagnosed. The diagnosis and management of thalamic abscess, and the interplay of type 2 diabetes and periodontitis are discussed. A 56-year-old, Caucasian, man with no medical or travel history, presented with 5-day symptoms of meningeal irritation. Body mass index 30.6 kg/m(2). CT demonstrated a solitary midline lesion with neoplasia as a differential diagnosis. It was biopsied and cultures grew Streptococcus milleri. He was treated by stereotactic puncture, external drainage and targeted intrathecal and systemic antibiotic therapy. HIV negative but glycated haemoglobin (HbA1c) 10.7% (93 mmol/mol). Dental examination revealed a small molar abscess. Radiological resolution of the thalamic abscess occurred within 2 months. Diabetes improved with 7 weeks of insulin, and maintained on metformin, HbA1c 6.9% (51 mmol/mol). There was no residual neurological disability.
authors: Department of Medicine, King's College Hospital, London, UK.
authors: Ioannis
authors: I
authors: Karageorgiou
authors: Department of Neurosurgery, King's College Hospital, London, UK.
authors: Christopher
authors: C
authors: Chandler
authors: Department of Diabetes, King's College Hospital, London, UK.
authors: Martin Brunel
authors: MB
authors: Whyte
mesh_terms: D001922:Brain Abscess / Q000150:complications* / Q000175:diagnosis / Q000382:microbiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003937:Diagnosis, Differential; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000150:complications* / Q000175:diagnosis / Q000382:microbiology; D013290:Streptococcal Infections / Q000150:complications* / Q000175:diagnosis / Q000382:microbiology; D034364:Streptococcus milleri Group / Q000302:isolation & purification; D013788:Thalamus; D014057:Tomography, X-Ray Computed