title: Spectroscopic characterization, antioxidant and antitumour studies of novel bromo substituted thiosemicarbazone and its copper(II), nickel(II) and palladium(II) complexes.
abstract: A new, slightly distorted octahedral complex of copper(II), square planar complexes of nickel(II) and palladium(II) with 2,4'-dibromoacetophenone thiosemicarbazone (DBAPTSC) are synthesized. The ligand and the complexes are characterized by FT-IR, FT-Raman, powder X-ray diffraction studies. The IR and Raman data are correlated for the presence of the functional groups which specifically helped in the confirmation of the compounds. In addition, the free ligand is unambiguously characterized by (1)H and (13)C NMR spectroscopy while the copper(II) complex is characterized by electron paramagnetic resonance spectroscopy (EPR). The g values for the same are found to be 2.246 (g1), 2.012 (g2) and 2.005 (g3) which suggested rhombic distortions. The HOMO-LUMO band gap calculations for these compounds are found to be in between 0.5 and 4.0 eV and these compounds are identified as semiconducting materials. The synthesized ligand and its copper(II), nickel(II) and palladium(II) complexes are subjected to antitumour activity against the HepG2 human hepatoblastoma cell lines. Among all the compounds, nickel(II) complex is found to exert better antitumour activity with 57.6% of cytotoxicity.
authors: Department of Chemistry, Sri Venkateswara University, Tirupati, AP 517502, India.
authors: M
authors: M
authors: Jagadeesh
authors: Department of Chemistry, Sri Venkateswara University, Tirupati, AP 517502, India.
authors: M
authors: M
authors: Lavanya
authors: School of Life Sciences, University of Hyderabad, Hyderabad, AP 500046, India.
authors: Suresh K
authors: SK
authors: Kalangi
authors: Chemical Engineering Department, CBIT, JNTU, Hyderabad, 500072, India.
authors: Y
authors: Y
authors: Sarala
authors: Department of Chemistry, Srikalahasteeswara Institute of Technology (SKIT), Srikalahasti, AP 517640, India.
authors: C
authors: C
authors: Ramachandraiah
authors: Department of Chemistry, Sri Venkateswara University, Tirupati, AP 517502, India. Electronic address: ammireddyv@yahoo.co.in.
authors: A
authors: A
authors: Varada Reddy
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D056831:Coordination Complexes / Q000494:pharmacology*; D003300:Copper / Q000494:pharmacology; D004578:Electron Spin Resonance Spectroscopy; D056945:Hep G2 Cells; D006801:Humans; D008024:Ligands; D009532:Nickel / Q000494:pharmacology; D010165:Palladium / Q000494:pharmacology; D011208:Powders; D066244:Proton Magnetic Resonance Spectroscopy; D017550:Spectroscopy, Fourier Transform Infrared; D013059:Spectrum Analysis, Raman; D013882:Thiosemicarbazones / Q000494:pharmacology*; D014961:X-Ray Diffraction
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D056831:Coordination Complexes; D008024:Ligands; D011208:Powders; D013882:Thiosemicarbazones; D010165:Palladium; D003300:Copper; D009532:Nickel
keywords: Antitumour activity; Dibromoacetophenone thiosemicarbazone; EPR spectra; Transition metal complexes