title: The association of metabolic syndrome and its factors with gallstone disease.
abstract: BACKGROUND
  To investigate the association between metabolic syndrome, including its factors, and gallstone disease (GSD) in a Taiwanese population.
  
  
  METHODS
  We conducted a cross-sectional study during 2011 ~ 2012. A total of 12050 subjects who completed a questionnaire and underwent physical examination, laboratory tests and abdominal ultrasonography formed the study population.
  
  
  RESULTS
  The prevalences of metabolic syndrome and gallstone disease were 24.09% and 6.16%. In an age- and sex-adjusted logistic regression model, metabolic syndrome was associated with gallstone disease (OR = 1.61; P < 0.0001). Age, abdominal obesity, and lower high-density lipoprotein cholesterol were associated with gallstone disease after adjusting for other factors. Females had a higher odds ratio than males in waist circumference for GSD, whereas males had a lower odds ratio than females in HDL-C for GSD.
  
  
  CONCLUSIONS
  The present study suggests that metabolic syndrome is related to gallstone disease. Waist circumference and high-density lipoprotein cholesterol are all associated with GSD. Men and women may possibly have different priorities and strategies to reduce the burden of GSD.
authors: I-Ching
authors: IC
authors: Lin
authors: Yu-Wen
authors: YW
authors: Yang
authors: Mei-Feng
authors: MF
authors: Wu
authors: Yi-Hui
authors: YH
authors: Yeh
authors: Jenn-Chang
authors: JC
authors: Liou
authors: Ying-Li
authors: YL
authors: Lin
authors: Family Medicine Department, Changhua Christian Hospital, No, 135, St, Nan-Xiao, Changhua City 500, Taiwan. a102067@cmu.edu.tw.
authors: Chih-Hsiang
authors: CH
authors: Chiang
mesh_terms: D000328:Adult; D000367:Age Factors; D002769:Cholelithiasis / Q000453:epidemiology; D008076:Cholesterol, HDL / Q000097:blood; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000097:blood / Q000453:epidemiology*; D005260:Female; D042882:Gallstones / Q000453:epidemiology*; D006801:Humans; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000453:epidemiology*; D012307:Risk Factors; D012737:Sex Factors; D013624:Taiwan / Q000453:epidemiology; D055105:Waist Circumference
chemical_list: D008076:Cholesterol, HDL