title: Enzymatic synthesis of polybrominated dioxins from the marine environment.
abstract: Polyhalogenated dibenzo-p-dioxins are arguably among the most toxic molecules known to man. In addition to anthropogenic sources, marine invertebrates also harbor polybrominated dibenzo-p-dioxins of as yet unknown biogenic origin. Here, we report that the bmp gene locus in marine bacteria, a recently characterized source of polybrominated diphenyl ethers, can also synthesize dibenzo-p-dioxins by employing different phenolic initiator molecules. Our findings also diversify the structural classes of diphenyl ethers accessed by the bmp biosynthetic pathway. This report lays the biochemical foundation of a likely biogenetic origin of dibenzo-p-dioxins present in the marine metabolome and greatly expands the toxicity potential of marine derived polyhaloganated natural products.
authors: Center for Oceans and Human Health, Scripps Institution of Oceanography and ‡Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California , San Diego, California 92093, United States.
authors: Vinayak
authors: V
authors: Agarwal
authors: Bradley S
authors: BS
authors: Moore
mesh_terms: D000818:Animals; D059001:Aquatic Organisms / Q000235:genetics / Q000378:metabolism*; D002396:Catechols / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004147:Dioxins / Q000378:metabolism*; D004798:Enzymes / Q000737:chemistry / Q000378:metabolism*; D020563:Gammaproteobacteria / Q000235:genetics / Q000378:metabolism; D055768:Halogenated Diphenyl Ethers / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D011075:Polybrominated Biphenyls / Q000378:metabolism*; D011161:Porifera / Q000378:metabolism; D014871:Water Microbiology
chemical_list: D002396:Catechols; D004147:Dioxins; D004798:Enzymes; D055768:Halogenated Diphenyl Ethers; D011075:Polybrominated Biphenyls; D003577:Cytochrome P-450 Enzyme System