title: Spectrophotometric method for estimation of bisoprolol fumarate in tablets.
abstract: Bisoprolol fumarate is prescribed for the treatment of hypertension and angina pectoris.
  
  
  OBJECTIVE
  The purpose of this study was to develop a simple, sensitive, accurate, and reproducible method for estimation of bisoprolol fumarate in tablets.
  
  
  METHODS
  The proposed method was based on a yellow colored complex formed with tropaeolin 00, extractable in dichloromethane with maximum absorbance at 412 nm. The method was validated statistically.
  
  
  RESULTS
  The linearity domain was observed in the concentration of 5-30 microg/ml. The recovery studies confirmed the accuracy of the proposed method.
  
  
  CONCLUSIONS
  The proposed method can be applied for the routine analysis of bisoprolol from formulations.
authors: Alina Diana
authors: AD
authors: Panainte
authors: Nela
authors: N
authors: Bibire
authors: Gladiola
authors: G
authors: Tântaru
authors: M
authors: M
authors: Apostu
authors: Mădălina
authors: M
authors: Vieriu
authors: V
authors: V
authors: Dorneanu
mesh_terms: D000959:Antihypertensive Agents / Q000032:analysis* / Q000737:chemistry; D001391:Azo Compounds / Q000737:chemistry; D001557:Benzenesulfonates / Q000737:chemistry; D017298:Bisoprolol / Q000032:analysis* / Q000737:chemistry; D004396:Coloring Agents / Q000737:chemistry; D004304:Dosage Forms; D004338:Drug Combinations; D008752:Methylene Chloride / Q000737:chemistry; D015203:Reproducibility of Results; D013053:Spectrophotometry / Q000379:methods*; D013607:Tablets / Q000032:analysis*
chemical_list: D000959:Antihypertensive Agents; D001391:Azo Compounds; D001557:Benzenesulfonates; D004396:Coloring Agents; D004304:Dosage Forms; D004338:Drug Combinations; D013607:Tablets; D008752:Methylene Chloride; C014722:2-naphthol orange; D017298:Bisoprolol