title: Postnatal development of dendritic structure of layer III pyramidal neurons in the medial prefrontal cortex of marmoset.
abstract: In the primate cerebral cortex, dendritic spines rapidly increase in number after birth up to infancy or mid-childhood, and then decrease towards adulthood. Abnormalities in these processes accompany several psychiatric disorders. In this study, we examined developmental changes of basal dendrites and spines of layer III pyramidal cells in the medial prefrontal cortex (mPFC) of the common marmoset. The mPFC consists of several areas with distinct features in layer organization, histochemistry, connections, and, in humans, vulnerability to psychiatric disorders. We selected three areas for examination: granular dorsomedial prefrontal (area 8B/9), dysgranular ventromedial prefrontal (area 14r), and agranular anterior cingulate (area 24) cortices. Dendritic field areas, lengths, number of branching points, and total spine number reached a peak at 2-3 postnatal months in all three areas. However, the profiles of spine formation and pruning differed across the three areas with different degrees of granularity; the amount of spine loss from the peak to adulthood was less in areas 24 (33%) and 14r (29%) than in area 8B/9 (43%). Disturbance of this modest spine pruning in the less granular cortical areas may lead to an excessive loss of spines reported for areas 24 and 14r of schizophrenic patients.
authors: Department of Ultrastructural Research, National Center of Neurology and Psychiatry, National Institute of Neuroscience, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo, 187-8502, Japan.
authors: Tetsuya
authors: T
authors: Sasaki
authors: Department of Ultrastructural Research, National Center of Neurology and Psychiatry, National Institute of Neuroscience, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo, 187-8502, Japan.|Graduate School of Frontier Biosciences, Osaka University, 1-4 Yamadaoka, Suita, Osaka, 565-0871, Japan.
authors: Hirosato
authors: H
authors: Aoi
authors: Department of Ultrastructural Research, National Center of Neurology and Psychiatry, National Institute of Neuroscience, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo, 187-8502, Japan.|Graduate School of Frontier Biosciences, Osaka University, 1-4 Yamadaoka, Suita, Osaka, 565-0871, Japan.
authors: Tomofumi
authors: T
authors: Oga
authors: Graduate School of Frontier Biosciences, Osaka University, 1-4 Yamadaoka, Suita, Osaka, 565-0871, Japan.|Center for Information and Neural Networks (CiNet), National Institute of Information and Communications Technology, Osaka University, 1-4 Yamadaoka, Suita, Osaka, 565-0871, Japan.
authors: Ichiro
authors: I
authors: Fujita
authors: Department of Ultrastructural Research, National Center of Neurology and Psychiatry, National Institute of Neuroscience, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo, 187-8502, Japan. nichino@ncnp.go.jp.
authors: Noritaka
authors: N
authors: Ichinohe
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002144:Callithrix / Q000033:anatomy & histology* / Q000254:growth & development; D003713:Dendritic Cells; D049229:Dendritic Spines / Q000502:physiology; D005260:Female; D008297:Male; D009473:Neuronal Plasticity / Q000502:physiology; D017397:Prefrontal Cortex / Q000166:cytology* / Q000254:growth & development; D017966:Pyramidal Cells / Q000166:cytology*
keywords: Basal dendrite; Cortical development; Granularity; Schizophrenia; Spine pruning