title: Health-related quality of life in preschool children with Type 1 diabetes.
abstract: OBJECTIVE
  To describe health-related quality of life in children aged < 7 years with Type 1 diabetes mellitus compared with healthy children of the same age, and to investigate how health-related quality of life was correlated with aspects of insulin treatment and glycaemic control.
  
  
  METHODS
  The participants in this study were 24 children with diabetes (12 girls, mean age 4.5 years) and 27 healthy children (14 girls, mean age 4.6 years). All participants completed the Pediatric Quality of Life Inventory 4.0 Generic Core Scales and the participants with diabetes also completed the Pediatric Quality of Life Inventory 3.0 Type 1 Diabetes Module Scales. HbA1c levels were measured in children with diabetes and the plasma glucose meter memories were uploaded.
  
  
  RESULTS
  Children aged <7 years with diabetes had lower parent-rated generic health-related quality of life compared with healthy children (score: 80 vs 91; P = 0.003). The difference was largest in children aged < 5 years (score: 79 vs 93; P = 0.004). Among the parents of children with Type 1 diabetes, 22% rated their child's generic health-related quality of life to be at a level of concern (- 1 sd of a general population). Of the children with Type 1 diabetes aged between 5 and 7 years, 40% rated their own generic health-related quality of life at the same level of concern.
  
  
  CONCLUSIONS
  This study shows a significantly lower level of generic health-related quality of life in very young children with diabetes in comparison with healthy children. We suggest screening for health-related quality of life in children of all ages with Type 1 diabetes mellitus.
authors: Diabetes Unit, The Queen Silvia Children's Hospital/Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Paediatrics, Institution of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
authors: F
authors: F
authors: Sundberg
authors: P
authors: P
authors: Sand
authors: G
authors: G
authors: Forsander
mesh_terms: D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D017028:Caregivers; D002652:Child Behavior; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000453:epidemiology / Q000523:psychology*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006304:Health Status; D006801:Humans; D008297:Male; D008403:Mass Screening; D011594:Psychometrics; D011788:Quality of Life; D011795:Surveys and Questionnaires; D013548:Sweden / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human