title: Relationship between types of radiographic damage and disability in patients with rheumatoid arthritis in the EURIDISS cohort: a longitudinal study.
abstract: OBJECTIVE
  The aim of this study was to assess if any of the different types of radiographic damage [true joint space narrowing (JSN), (sub)luxation and erosions] are preferentially related to disability in patients with RA.
  
  
  METHODS
  Longitudinal data from 167 RA patients from the European Research on Incapacitating Diseases and Social Support study over 10 years were analysed to investigate the relationship between the three types of radiographic damage and disability [grip strength, HAQ and the dexterity scale in the Arthritis Impact Measurement Scales (AIMS)]. A longitudinal analysis including separate models per type of damage and joint group and combined models including all information was conducted.
  
  
  RESULTS
  All types of damage were inversely related to grip strength in the analysis of separate models, but only true JSN independently remained statistically significant in the combined analysis [β = -0.087 (95% CI -0.151, -0.022)]. Neither JSN, (sub)luxation nor erosions were associated with HAQ score, while erosions were associated with AIMS dexterity only in the analysis of separate models. After stratifying for hand joint group, erosions at MCP joints [β = -0.288 (95% CI -0.556, -0.019)] and true JSN at the wrist [β = -0.132 (95% CI -0.234, -0.030)] were significantly related to grip strength. Erosions at the PIP [β = 0.017 (95% CI 0.005, 0.028)] and MCP joints [β = 0.114 (95% CI 0.010, 0.217)] was the only type of damage associated with HAQ and AIMS dexterity, respectively.
  
  
  CONCLUSIONS
  All types of radiographically visible joint damage interfere with important aspects of physical functions. True JSN is most closely related to hand function.
authors: Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Department of Rheumatology, University Hospital La Paz, Madrid, Spain, Department of Clinical Immunology and Rheumatology, Amsterdam Rheumatology Center, University of Amsterdam, Amsterdam, Department of Rheumatology, Atrium Medical Center Heerlen, Heerlen, The Netherlands, Department of Rheumatology, Diakonhjemmet Hospital, National Unit on Rehabilitation in Rheumatology, National Advisory Unit on Rehabilitation in Rheumatology, Department of Epidemiology, Maastricht University, Maastricht, The Netherlands and Department of Rheumatology, Hospital Garcia de Orta, Almada, Portugal. Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Department of Rheumatology, University Hospital La Paz, Madrid, Spain, Department of Clinical Immunology and Rheumatology, Amsterdam Rheumatology Center, University of Amsterdam, Amsterdam, Department of Rheumatology, Atrium Medical Center Heerlen, Heerlen, The Netherlands, Department of Rheumatology, Diakonhjemmet Hospital, National Unit on Rehabilitation in Rheumatology, National Advisory Unit on Rehabilitation in Rheumatology, Department of Epidemiology, Maastricht University, Maastricht, The Netherlands and Department of Rheumatology, Hospital Garcia de Orta, Almada, Portugal. mvictoria.navarroc@gmail.com.
authors: Victoria
authors: V
authors: Navarro-Compán
authors: Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Department of Rheumatology, University Hospital La Paz, Madrid, Spain, Department of Clinical Immunology and Rheumatology, Amsterdam Rheumatology Center, University of Amsterdam, Amsterdam, Department of Rheumatology, Atrium Medical Center Heerlen, Heerlen, The Netherlands, Department of Rheumatology, Diakonhjemmet Hospital, National Unit on Rehabilitation in Rheumatology, National Advisory Unit on Rehabilitation in Rheumatology, Department of Epidemiology, Maastricht University, Maastricht, The Netherlands and Department of Rheumatology, Hospital Garcia de Orta, Almada, Portugal. Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Department of Rheumatology, University Hospital La Paz, Madrid, Spain, Department of Clinical Immunology and Rheumatology, Amsterdam Rheumatology Center, University of Amsterdam, Amsterdam, Department of Rheumatology, Atrium Medical Center Heerlen, Heerlen, The Netherlands, Department of Rheumatology, Diakonhjemmet Hospital, National Unit on Rehabilitation in Rheumatology, National Advisory Unit on Rehabilitation in Rheumatology, Department of Epidemiology, Maastricht University, Maastricht, The Netherlands and Department of Rheumatology, Hospital Garcia de Orta, Almada, Portugal.
authors: Robert
authors: R
authors: Landewé
authors: Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Department of Rheumatology, University Hospital La Paz, Madrid, Spain, Department of Clinical Immunology and Rheumatology, Amsterdam Rheumatology Center, University of Amsterdam, Amsterdam, Department of Rheumatology, Atrium Medical Center Heerlen, Heerlen, The Netherlands, Department of Rheumatology, Diakonhjemmet Hospital, National Unit on Rehabilitation in Rheumatology, National Advisory Unit on Rehabilitation in Rheumatology, Department of Epidemiology, Maastricht University, Maastricht, The Netherlands and Department of Rheumatology, Hospital Garcia de Orta, Almada, Portugal.
authors: Sella A
authors: SA
authors: Provan
authors: Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Department of Rheumatology, University Hospital La Paz, Madrid, Spain, Department of Clinical Immunology and Rheumatology, Amsterdam Rheumatology Center, University of Amsterdam, Amsterdam, Department of Rheumatology, Atrium Medical Center Heerlen, Heerlen, The Netherlands, Department of Rheumatology, Diakonhjemmet Hospital, National Unit on Rehabilitation in Rheumatology, National Advisory Unit on Rehabilitation in Rheumatology, Department of Epidemiology, Maastricht University, Maastricht, The Netherlands and Department of Rheumatology, Hospital Garcia de Orta, Almada, Portugal. Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Department of Rheumatology, University Hospital La Paz, Madrid, Spain, Department of Clinical Immunology and Rheumatology, Amsterdam Rheumatology Center, University of Amsterdam, Amsterdam, Department of Rheumatology, Atrium Medical Center Heerlen, Heerlen, The Netherlands, Department of Rheumatology, Diakonhjemmet Hospital, National Unit on Rehabilitation in Rheumatology, National Advisory Unit on Rehabilitation in Rheumatology, Department of Epidemiology, Maastricht University, Maastricht, The Netherlands and Department of Rheumatology, Hospital Garcia de Orta, Almada, Portugal.
authors: Sigrid
authors: S
authors: Ødegård
authors: Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Department of Rheumatology, University Hospital La Paz, Madrid, Spain, Department of Clinical Immunology and Rheumatology, Amsterdam Rheumatology Center, University of Amsterdam, Amsterdam, Department of Rheumatology, Atrium Medical Center Heerlen, Heerlen, The Netherlands, Department of Rheumatology, Diakonhjemmet Hospital, National Unit on Rehabilitation in Rheumatology, National Advisory Unit on Rehabilitation in Rheumatology, Department of Epidemiology, Maastricht University, Maastricht, The Netherlands and Department of Rheumatology, Hospital Garcia de Orta, Almada, Portugal. Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Department of Rheumatology, University Hospital La Paz, Madrid, Spain, Department of Clinical Immunology and Rheumatology, Amsterdam Rheumatology Center, University of Amsterdam, Amsterdam, Department of Rheumatology, Atrium Medical Center Heerlen, Heerlen, The Netherlands, Department of Rheumatology, Diakonhjemmet Hospital, National Unit on Rehabilitation in Rheumatology, National Advisory Unit on Rehabilitation in Rheumatology, Department of Epidemiology, Maastricht University, Maastricht, The Netherlands and Department of Rheumatology, Hospital Garcia de Orta, Almada, Portugal.
authors: Till
authors: T
authors: Uhlig
authors: Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Department of Rheumatology, University Hospital La Paz, Madrid, Spain, Department of Clinical Immunology and Rheumatology, Amsterdam Rheumatology Center, University of Amsterdam, Amsterdam, Department of Rheumatology, Atrium Medical Center Heerlen, Heerlen, The Netherlands, Department of Rheumatology, Diakonhjemmet Hospital, National Unit on Rehabilitation in Rheumatology, National Advisory Unit on Rehabilitation in Rheumatology, Department of Epidemiology, Maastricht University, Maastricht, The Netherlands and Department of Rheumatology, Hospital Garcia de Orta, Almada, Portugal.
authors: Tore K
authors: TK
authors: Kvien
authors: Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Department of Rheumatology, University Hospital La Paz, Madrid, Spain, Department of Clinical Immunology and Rheumatology, Amsterdam Rheumatology Center, University of Amsterdam, Amsterdam, Department of Rheumatology, Atrium Medical Center Heerlen, Heerlen, The Netherlands, Department of Rheumatology, Diakonhjemmet Hospital, National Unit on Rehabilitation in Rheumatology, National Advisory Unit on Rehabilitation in Rheumatology, Department of Epidemiology, Maastricht University, Maastricht, The Netherlands and Department of Rheumatology, Hospital Garcia de Orta, Almada, Portugal.
authors: András P
authors: AP
authors: Keszei
authors: Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Department of Rheumatology, University Hospital La Paz, Madrid, Spain, Department of Clinical Immunology and Rheumatology, Amsterdam Rheumatology Center, University of Amsterdam, Amsterdam, Department of Rheumatology, Atrium Medical Center Heerlen, Heerlen, The Netherlands, Department of Rheumatology, Diakonhjemmet Hospital, National Unit on Rehabilitation in Rheumatology, National Advisory Unit on Rehabilitation in Rheumatology, Department of Epidemiology, Maastricht University, Maastricht, The Netherlands and Department of Rheumatology, Hospital Garcia de Orta, Almada, Portugal. Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Department of Rheumatology, University Hospital La Paz, Madrid, Spain, Department of Clinical Immunology and Rheumatology, Amsterdam Rheumatology Center, University of Amsterdam, Amsterdam, Department of Rheumatology, Atrium Medical Center Heerlen, Heerlen, The Netherlands, Department of Rheumatology, Diakonhjemmet Hospital, National Unit on Rehabilitation in Rheumatology, National Advisory Unit on Rehabilitation in Rheumatology, Department of Epidemiology, Maastricht University, Maastricht, The Netherlands and Department of Rheumatology, Hospital Garcia de Orta, Almada, Portugal.
authors: Sofia
authors: S
authors: Ramiro
authors: Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Department of Rheumatology, University Hospital La Paz, Madrid, Spain, Department of Clinical Immunology and Rheumatology, Amsterdam Rheumatology Center, University of Amsterdam, Amsterdam, Department of Rheumatology, Atrium Medical Center Heerlen, Heerlen, The Netherlands, Department of Rheumatology, Diakonhjemmet Hospital, National Unit on Rehabilitation in Rheumatology, National Advisory Unit on Rehabilitation in Rheumatology, Department of Epidemiology, Maastricht University, Maastricht, The Netherlands and Department of Rheumatology, Hospital Garcia de Orta, Almada, Portugal. Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Department of Rheumatology, University Hospital La Paz, Madrid, Spain, Department of Clinical Immunology and Rheumatology, Amsterdam Rheumatology Center, University of Amsterdam, Amsterdam, Department of Rheumatology, Atrium Medical Center Heerlen, Heerlen, The Netherlands, Department of Rheumatology, Diakonhjemmet Hospital, National Unit on Rehabilitation in Rheumatology, National Advisory Unit on Rehabilitation in Rheumatology, Department of Epidemiology, Maastricht University, Maastricht, The Netherlands and Department of Rheumatology, Hospital Garcia de Orta, Almada, Portugal.
authors: Désirée
authors: D
authors: van der Heijde
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D015331:Cohort Studies; D004185:Disability Evaluation; D018450:Disease Progression; D005060:Europe; D005260:Female; D005500:Follow-Up Studies; D018737:Hand Strength / Q000502:physiology; D062489:Health Impact Assessment; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009664:Norway; D011859:Radiography; D012189:Retrospective Studies; D012216:Rheumatic Diseases; D012720:Severity of Illness Index; D012944:Social Support; D014955:Wrist Joint / Q000000981:diagnostic imaging / Q000503:physiopathology
keywords: JSN; Sharp–van der Heijde; disability; erosion; radiographic damage; rheumatoid arthritis; subluxation