title: Receptor for advanced glycation end products (RAGE) and its ligands: focus on spinal cord injury.
abstract: Spinal cord injury (SCI) results in neuronal and glial death and the loss of axons at the injury site. Inflammation after SCI leads to the inhibition of tissue regeneration and reduced neuronal survival. In addition, the loss of axons after SCI results in functional loss below the site of injury accompanied by neuronal cell body's damage. Consequently, reducing inflammation and promoting axonal regeneration after SCI is a worthy therapeutic goal. The receptor for advanced glycation end products (RAGE) is a transmembrane protein and receptor of the immunoglobulin superfamily. RAGE is implicated in inflammation and neurodegeneration. Several recent studies demonstrated an association between RAGE and central nervous system disorders through various mechanisms. However, the relationship between RAGE and SCI has not been shown. It is imperative to elucidate the association between RAGE and SCI, considering that RAGE relates to inflammation and axonal degeneration following SCI. Hence, the present review highlights recent research regarding RAGE as a compelling target for the treatment of SCI.
authors: Department of Anatomy, Yonsei University College of Medicine, Seoul 120-752, Korea. sjh1008@yuhs.ac.
authors: Juhyun
authors: J
authors: Song
authors: Department of Anatomy, Yonsei University College of Medicine, Seoul 120-752, Korea. inskull@yuhs.ac.
authors: Won Taek
authors: WT
authors: Lee
authors: Department of Anatomy, Yonsei University College of Medicine, Seoul 120-752, Korea. kapark@yuhs.ac.
authors: Kyung Ah
authors: KA
authors: Park
authors: Department of Anatomy, Yonsei University College of Medicine, Seoul 120-752, Korea. jelee@yuhs.ac.
authors: Jong Eun
authors: JE
authors: Lee
mesh_terms: D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology; D008024:Ligands; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000737:chemistry / Q000378:metabolism*; D012583:Schwann Cells / Q000166:cytology / Q000378:metabolism; D013119:Spinal Cord Injuries / Q000378:metabolism / Q000473:pathology*
chemical_list: D008024:Ligands; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic