title: Pin1: a molecular orchestrator in the heart.
abstract: Pin1 is an evolutionarily conserved peptidyl-prolyl isomerase that binds and changes the three-dimensional conformation of specific phospho-proteins. By regulating protein structure and folding, Pin1 affects the stability, interaction, and activity of a broad spectrum of target proteins, thus impacting upon diverse cellular processes. This review discusses the pivotal role Pin1 plays in regulating cardiac pathophysiology by functioning as a "molecular orchestrator" of a myriad of signal transduction pathways in the heart.
authors: Department of Biology, San Diego State University Heart Institute, San Diego State University, North Life Sciences, San Diego, CA.
authors: Nirmala
authors: N
authors: Hariharan
authors: Department of Biology, San Diego State University Heart Institute, San Diego State University, North Life Sciences, San Diego, CA. Electronic address: heartman4ever@icloud.com.
authors: Mark A
authors: MA
authors: Sussman
mesh_terms: D002468:Cell Physiological Phenomena; D006801:Humans; D009206:Myocardium / Q000378:metabolism*; D019696:Peptidylprolyl Isomerase / Q000378:metabolism*; D010750:Phosphoproteins / Q000378:metabolism*; D010766:Phosphorylation / Q000502:physiology; D015398:Signal Transduction
chemical_list: D010750:Phosphoproteins; D019696:Peptidylprolyl Isomerase