title: Maternal exposure to the production of fireworks and reduced rate of new onset hypertension in pregnancy.
abstract: BACKGROUND
  Carbon monoxide (CO) is one of the main substances contained in fireworks. Previous studies suggested that CO may have protective effect on the development of hypertension of pregnancy.
  
  
  METHODS
  The authors conducted a prospective cohort study in Liuyang, Hunan, China between January 2010 and December 2011. Demographic and life-style variables of the participating pregnant women were obtained through structured interview with the women and clinical data were retrieved from antenatal medical records. Density of fireworks factories was defined as the number of fireworks factories per 1000 residents in the township where the mothers resided during pregnancy. Multiple logistic regression analysis was used to analyze the independent association between maternal exposure to the production of fireworks and new onset hypertension in pregnancy.
  
  
  RESULTS
  A total of 5976 pregnant women were included in the final analysis. Density of fireworks factories was inversely correlated with incidence of new onset hypertension in pregnancy (Pearson correlation coefficient = -0.29, p < 0.001). Multiple logistic regression analysis showed that, compared with women who resided during pregnancy in a township with 0-0.25 fireworks factories per 1000 residents, the rates of new onset hypertension in pregnancy in women who resided in a township with 0.26-1.00 fireworks factories per 1000 residents (Odds Ratio = 0.66, 95% confidence interval: 0.46, 0.96) and >1.5 fireworks factories per 1000 residents (Odds Ratio = 0.65, 95% confidence interval: 0.44, 0.97) were reduced by more than 30%.
  
  
  CONCLUSIONS
  Maternal exposure to the high density of fireworks factories is associated with reduced risk of developing new onset hypertension in pregnancy.
authors: School of Public Health, Central South University , Changsha , China .
authors: Mei-Ling
authors: ML
authors: Luo
authors: Hong-Zhuan
authors: HZ
authors: Tan
authors: Ri-Hua
authors: RH
authors: Xie
authors: Shu-Jin
authors: SJ
authors: Zhou
authors: Ravi
authors: R
authors: Retnakaran
authors: Graeme
authors: G
authors: Smith
authors: Mark C
authors: MC
authors: Walker
authors: Sandra T
authors: ST
authors: Davidge
authors: Jacquetta
authors: J
authors: Trasler
authors: Shi Wu
authors: SW
authors: Wen
mesh_terms: D000328:Adult; D002248:Carbon Monoxide; D002681:China / Q000453:epidemiology; D053834:Explosive Agents; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000453:epidemiology*; D066192:Manufacturing Industry; D011247:Pregnancy; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D053834:Explosive Agents; D002248:Carbon Monoxide
keywords: Carbon monoxide; Cohort study; Fireworks hypertension; Pregnancy