title: PRC1 complex diversity: where is it taking us?
abstract: Polycomb group proteins (PcGs) are essential epigenetic regulators that play key roles in development, pluripotency, senescence, and cancer. Recent reports have found that the composition of mammalian Polycomb repressive complex 1 (PRC1) is far more varied than previously thought. PRC1 diversity largely depends on the presence of CBX proteins, dividing them into canonical and non-canonical, the existence of redundant subunits, and different binding affinities and/or regulation. However, there is no clear insight into how many functional PRC1 complexes exist and what the biological relevance is for such diversification. In this review we focus on mammalian PRC1 and discuss the mechanisms by which canonical and non-canonical PRC1 are recruited to chromatin, their role in normal development and disease, and emerging evidence for PRC1 as a transcriptional activator.
authors: Cell Proliferation Group, Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Campus, London W12 0NN, UK.
authors: Jesús
authors: J
authors: Gil
authors: Epigenetics and Cellular Senescence Group, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK. Electronic address: a.ologhlen@qmul.ac.uk.
authors: Ana
authors: A
authors: O'Loghlen
mesh_terms: D000818:Animals; D016922:Cellular Senescence; D002843:Chromatin / Q000235:genetics*; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000235:genetics; D063150:Polycomb Repressive Complex 1 / Q000235:genetics*; D063146:Polycomb-Group Proteins / Q000235:genetics*
chemical_list: D002843:Chromatin; D063146:Polycomb-Group Proteins; D063150:Polycomb Repressive Complex 1
keywords: CBX; KDM2; PRC1; Polycomb; chromobox protein