title: MicroRNA and signaling pathways in gastric cancer.
abstract: MicroRNAs (miRNAs) function as either oncogenes or tumor suppressors by inhibiting the expression of target genes, some of which are either directly or indirectly involved with canonical signaling pathways. The relationship between miRNAs and signaling pathways in gastric cancer is extremely complicated. In this paper, we determined the pathogenic mechanism of gastric cancer related to miRNA expression based on recent high-quality studies and then clarified the regulation network of miRNA expression and the correlated functions of these miRNAs during the progression of gastric cancer. We try to illustrate the correlation between the expression of miRNAs and outcomes of patients with gastric cancer. Understanding this will allow us to take a big step forward in the treatment of gastric cancer.
authors: Department of Oncological Surgery, Affiliated Hospital of Hebei University, Baoding, China.
authors: Z
authors: Z
authors: Zhang
authors: Department of Oncological Surgery, Affiliated Hospital of Hebei University, Baoding, China.
authors: Z
authors: Z
authors: Li
authors: Department of Gastric Cancer, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
authors: Y
authors: Y
authors: Li
authors: Department of Oncological Surgery, Affiliated Hospital of Hebei University, Baoding, China.
authors: A
authors: A
authors: Zang
mesh_terms: D000818:Animals; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism* / Q000628:therapy
chemical_list: D035683:MicroRNAs