title: A 20-year prospective study of Wilms tumor and other kidney tumors: a report from Hong Kong pediatric hematology and oncology study group.
abstract: BACKGROUND
  Renal tumors are one of the most common tumors in children. We aim at evaluating the characteristics and the outcome of Wilms tumor and other malignant kidney tumors in Hong Kong.
  
  
  METHODS
  Between January 1990 to December 2010, 68 patients under the age of 18 with malignant renal tumors were diagnosed and received treatment in Hong Kong. Clinical records were updated regularly. Prognostic factors and survival rate were evaluated.
  
  
  RESULTS
  Fifty-four patients were diagnosed with Wilms tumor. The annual incidence was estimated to be 2.29 per million. The mean age was 38 months. Median follow-up was 9.2 years. The event-free survival and overall survival rate at 10 years were 85.2% and 92.6%, respectively. A pair of siblings with familial extrarenal Wilms tumor was included. Pulmonary metastasis did exhibit a significant difference in survival rate. Eight cases of clear cell sarcoma of the kidneys were reported and the survival rate was 100%.
  
  
  CONCLUSIONS
  The clinical characteristics and outcome of the patients diagnosed Wilms tumor were comparable with other developed countries. Relatively high proportion and excellent outcome were found in clear cell sarcoma of the kidneys.
authors: *Department of Pediatrics, Lady Pao Children's Cancer Centre †Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT ‡Department of Pediatrics, Queen Elizabeth Hospital §Department of Pediatrics and Adolescent Medicine, Queen Mary Hospital ∥Department of Pediatrics and Adolescent Medicine, Princess Margaret Hospital ¶Department of Pediatrics, Tuen Mun Hospita, Hong Kong.
authors: Ching Ching
authors: CC
authors: Chan
authors: Ka Fai
authors: KF
authors: To
authors: Hui Leung
authors: HL
authors: Yuen
authors: Alan Kwok
authors: AK
authors: Shing Chiang
authors: Siu Cheung
authors: SC
authors: Ling
authors: Chak Ho
authors: CH
authors: Li
authors: Daniel Ka Leung
authors: DK
authors: Cheuk
authors: Chi Kong
authors: CK
authors: Li
authors: Matthew Ming Kong
authors: MM
authors: Shing
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007223:Infant; D007680:Kidney Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D008175:Lung Neoplasms / Q000401:mortality* / Q000556:secondary / Q000628:therapy; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000401:mortality; D011379:Prognosis; D011446:Prospective Studies; D018227:Sarcoma, Clear Cell / Q000401:mortality* / Q000556:secondary / Q000628:therapy; D015996:Survival Rate; D009396:Wilms Tumor / Q000401:mortality* / Q000473:pathology / Q000628:therapy