title: Renal function, acute kidney injury and hospital mortality in patients with acute myocardial infarction.
abstract: OBJECTIVE
  To examine retrospectively the relationship between acute kidney injury (AKI) and acute myocardial infarction (AMI), and the association between estimated glomerular filtration rate (eGFR) at admission and AKI outcome.
  
  
  METHODS
  AKI was defined as an increase in serum creatinine (SCr) by ≥ 0.3 mg/dl within 48 h or an increase in SCr to ≥ 1.5 times baseline within the first 7 days of hospitalization. Patients with AMI were divided into subgroups according to their eGFR at admission and the development of AKI.
  
  
  RESULTS
  This study enrolled 396 patients with AMI; 48 (12.1%) developed AKI. In-hospital mortality was 39.6% (19/48) for patients with AKI compared with 7.5% (26/348) in those without AKI (odds ratio [OR] 8.11; 95% confidence interval [CI] 4.02, 16.39). The mortality rate was 35.7% (five of 14) in the eGFR ≥ 60 ml/min/1.73 m(2) with AKI group (OR 6.21, 95% CI 1.50, 25.69) and 41.2% (14/34) in the eGFR <60 ml/min/1.73 m(2) with AKI group (OR 12.62, 95% CI 5.54, 28.74).
  
  
  CONCLUSIONS
  AKI development was common and associated with mortality in AMI patients with either preserved or impaired eGFR levels.
authors: Department of Cardiology, The Affiliated Longyan First Hospital of Fujian Medical University, Longyan, Fujian Province, China.
authors: Ying
authors: Y
authors: Liao
authors: Department of Urology, The Affiliated Longyan First Hospital of Fujian Medical University, Longyan, Fujian Province, China wingjays@163.com.
authors: Xingmo
authors: X
authors: Dong
authors: Department of Cardiology, The Affiliated Longyan First Hospital of Fujian Medical University, Longyan, Fujian Province, China.
authors: Kaihong
authors: K
authors: Chen
authors: Department of Cardiology, The Affiliated Longyan First Hospital of Fujian Medical University, Longyan, Fujian Province, China.
authors: Yong
authors: Y
authors: Fang
authors: Department of Cardiology, The Affiliated Longyan First Hospital of Fujian Medical University, Longyan, Fujian Province, China.
authors: Weiguo
authors: W
authors: Li
authors: Department of Cardiology, The Affiliated Longyan First Hospital of Fujian Medical University, Longyan, Fujian Province, China.
authors: Guoyong
authors: G
authors: Huang
mesh_terms: D000208:Acute Disease; D058186:Acute Kidney Injury / Q000150:complications / Q000401:mortality* / Q000473:pathology; D000368:Aged; D003404:Creatinine / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D017052:Hospital Mortality; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology / Q000401:mortality* / Q000473:pathology; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D013997:Time Factors
chemical_list: D003404:Creatinine
keywords: Acute kidney injury; acute myocardial infarction; glomerular filtration rate; mortality; renal function