title: Recovery of vascular function after exposure to a single bout of segmental vibration.
abstract: Work rotation schedules may be used to reduce the negative effects of vibration on vascular function. This study determined how long it takes vascular function to recover after a single exposure to vibration in rats (125 Hz, acceleration 5 g). The responsiveness of rat-tail arteries to the vasoconstricting factor UK14304, an α2C-adrenoreceptor agonist, and the vasodilating factor acetylcholine (ACh) were measured ex vivo 1, 2, 7, or 9 d after exposure to a single bout of vibration. Vasoconstriction induced by UK14304 returned to control levels after 1 d of recovery. However, re-dilation induced by ACh did not return to baseline until after 9 d of recovery. Exposure to vibration exerted prolonged effects on peripheral vascular function, and altered vascular responses to a subsequent exposure. To optimize the positive results of work rotation schedules, it is suggested that studies assessing recovery of vascular function after exposure to a single bout of vibration be performed in humans.
authors: a Engineering and Controls Technology Branch , Health Effects Laboratory Division, National Institute for Occupational Safety and Health , Morgantown , West Virginia , USA.
authors: Kristine
authors: K
authors: Krajnak
authors: Stacey
authors: S
authors: Waugh
authors: G Roger
authors: GR
authors: Miller
authors: Claud
authors: C
authors: Johnson
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001158:Arteries / Q000503:physiopathology*; D000068438:Brimonidine Tartrate; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000503:physiopathology*; D008297:Male; D011810:Quinoxalines / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014661:Vasoconstriction; D014732:Vibration / Q000009:adverse effects*
chemical_list: D011810:Quinoxalines; D000068438:Brimonidine Tartrate; D000109:Acetylcholine