title: A chemically standardized extract of Ziziphus jujuba fruit (Jujube) stimulates expressions of neurotrophic factors and anti-oxidant enzymes in cultured astrocytes.
abstract: The fruit of Ziziphus jujuba Mill., known as jujube or Chinese date, is commonly consumed as a health supplement worldwide. To study the role of jujube in brain benefits, the expression of neurotrophic factors and anti-oxidant enzymes in the jujube-treated cultured astrocytes was determined. Application of a chemical standardized water extract of jujube in cultured astrocytes for 24 h stimulated the expressions of nerve growth factor, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor in a concentration-dependent manner. The pre-treatment with H89, a protein kinase A inhibitor, attenuated the jujube-induced expression of neurotrophic factors. In parallel, the treatment of jujube water extract induced the transcriptional expressions of the enzymes responsible for anti-oxidation, i.e.
  quinine oxidoreductase 1, glutamate-cysteine ligase catalytic subunit, glutamate-cysteine ligase modifier subunit and glutathione S-transferase, in a concentration-dependent manner. These results proposed the benefits of jujube in regulating expressions of neurotrophic factors and anti-oxidant enzymes in cultured astrocytes.
authors: Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China.
authors: Jianping
authors: J
authors: Chen
authors: Artemis L
authors: AL
authors: Yan
authors: Kelly Y C
authors: KY
authors: Lam
authors: Candy T W
authors: CT
authors: Lam
authors: Ning
authors: N
authors: Li
authors: Ping
authors: P
authors: Yao
authors: Aizhen
authors: A
authors: Xiong
authors: Tina T X
authors: TT
authors: Dong
authors: Karl W K
authors: KW
authors: Tsim
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001253:Astrocytes / Q000187:drug effects* / Q000201:enzymology; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D002478:Cells, Cultured; D005638:Fruit / Q000737:chemistry; D051100:Glial Cell Line-Derived Neurotrophic Factor / Q000378:metabolism; D005721:Glutamate-Cysteine Ligase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000378:metabolism; D020932:Nerve Growth Factor / Q000378:metabolism; D009414:Nerve Growth Factors / Q000378:metabolism*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D017207:Rats, Sprague-Dawley; D031957:Ziziphus / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D019208:Brain-Derived Neurotrophic Factor; D051100:Glial Cell Line-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D010936:Plant Extracts; D020932:Nerve Growth Factor; D016660:NAD(P)H Dehydrogenase (Quinone); C507703:NQO1 protein, rat; D005982:Glutathione Transferase; C000593996:GCLM protein, rat; D005721:Glutamate-Cysteine Ligase; C544143:GCLC protein, rat
keywords: Rhamnaceae; Ziziphus jujuba; anti-oxidant enzyme; neurotrophic factor