title: Treatment outcome for gastric mucosa-associated lymphoid tissue lymphoma according to Helicobacter pylori infection status: a single-center experience.
abstract: OBJECTIVE
  Helicobacter pylori eradication therapy has been used as a first-line treatment for H. pylori-positive gastric mucosa-associated lymphoid tissue (MALT) lymphoma. However, the management strategy for H. pylori-negative MALT lymphoma remains controversial. Therefore, the aim of this study was to examine the success rate of each treatment option for H. pylori-positive and H. pylori-negative gastric MALT lymphomas.
  
  
  METHODS
  In total, 57 patients with gastric MALT lymphoma diagnosed between December 2000 and June 2012 were enrolled in the study. The treatment responses were compared between H. pylori-positive and H. pylori-negative gastric MALT lymphomas.
  
  
  RESULTS
  Of the 57 patients, 43 (75%) had H. pylori infection. Forty-eight patients received H. pylori eradication as a first-line treatment, and complete remission was achieved in 31 of the 39 patients (80%) with H. pylori-positive MALT lymphoma and in five (56%) of the nine patients with H. pylori-negative MALT lymphoma; no significant difference was observed between the groups (p=0.135). The other treatment modalities, including radiation therapy, chemotherapy, and surgery, were effective irrespective of H. pylori infection status, with no significant difference in the treatment response between H. pylori-positive and H. pylori-negative MALT lymphomas.
  
  
  CONCLUSIONS
  H. pylori eradication therapy may be considered as a first-line treatment regardless of H. pylori infection status.
authors: Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
authors: Kwang Duck
authors: KD
authors: Ryu
authors: Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
authors: Gwang Ha
authors: GH
authors: Kim
authors: Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
authors: Seong Oh
authors: SO
authors: Park
authors: Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
authors: Kwang Jae
authors: KJ
authors: Lee
authors: Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
authors: Jung Youn
authors: JY
authors: Moon
authors: Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
authors: Hye Kyung
authors: HK
authors: Jeon
authors: Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
authors: Dong Hoon
authors: DH
authors: Baek
authors: Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
authors: Bong Eun
authors: BE
authors: Lee
authors: Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
authors: Geun Am
authors: GA
authors: Song
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D005260:Female; D005753:Gastric Mucosa; D005773:Gastroscopy / Q000379:methods*; D016481:Helicobacter Infections / Q000150:complications / Q000628:therapy*; D016480:Helicobacter pylori; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000150:complications / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000150:complications / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents
keywords: B-cell; Eradication; Helicobacter pylori; Lymphoma; Radiotherapy; Stomach; marginal zone