title: Prenatal management, pregnancy and pediatric outcomes in fetuses with septated cystic hygroma.
abstract: It has been reported that, compared with simple increased nuchal translucency, fetal cases with septated cystic hygroma (CH) are more likely to face perinatal handicaps. However, pediatric outcomes and proper prenatal counseling for this anomaly have not yet been truly defined. We performed this study to determine pregnancy and pediatric outcomes of fetuses with septated CH. We searched records for cases with septated CH and collected data for structural abnormalities, karyotype analysis, and pregnancy outcomes. Fetuses born with septated CH were also evaluated for their pediatric outcomes. Sixty-nine fetuses with septated CH were enrolled in the study. Results showed that chromosomal abnormalities were present in 28 fetuses (40.6%), and the most common aneuploidy was Turner syndrome (n=14, 20.3%); 16 (23.2%) of the remaining cases, in which aneuploidy was not found, had coexistent structural malformations; 25 (36.2%) cases had normal karyotype and morphology. The total number of live births and infants with unfavorable neurologic follow-up were 13 (18.8%) and 2 (2.9%), respectively. Septated CH is associated with poor perinatal outcomes; therefore, karyotype analysis and ultrasonographic anomaly screening should be performed as initial steps, and expectant management should be offered to couples with euploid fetuses that have normal morphology.
authors: Department of Obstetrics and Gynecology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
authors: C Y
authors: CY
authors: Sanhal
authors: Department of Obstetrics and Gynecology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
authors: I
authors: I
authors: Mendilcioglu
authors: Department of Obstetrics and Gynecology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
authors: M
authors: M
authors: Ozekinci
authors: Department of Medical Biology and Genetics, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
authors: S
authors: S
authors: Yakut
authors: Department of Obstetrics and Gynecology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
authors: Z
authors: Z
authors: Merdun
authors: Department of Obstetrics and Gynecology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
authors: M
authors: M
authors: Simsek
authors: Department of Medical Biology and Genetics, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
authors: G
authors: G
authors: Luleci
mesh_terms: D000782:Aneuploidy; D002869:Chromosome Aberrations; D005260:Female; D005313:Fetal Death / Q000209:etiology; D006801:Humans; D015160:Hydrops Fetalis / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000235:genetics*; D059785:Karyotype; D007621:Karyotyping; D018191:Lymphangioma, Cystic / Q000150:complications / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000235:genetics*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011296:Prenatal Diagnosis; D011379:Prognosis; D012189:Retrospective Studies; D014421:Turkey / Q000453:epidemiology; D016216:Ultrasonography, Prenatal