title: Continuous recycling of homogeneous Pd/Cu catalysts for cross-coupling reactions.
abstract: Given the importance of homogeneous catalysts recycling in organic chemistry, we have developed a unique microfluidic loop system for automated continuous recirculation of a soluble polymer supported metal catalyst for novel isocyanide cross-coupling reactions under thermomorphic multicomponent solvent (TMS) conditions. Our system provides an innovative approach for the chemical library synthesis of quinazolinone derivatives as well as an important intermediate of Merck's LTD4 antagonist "Singulair" with efficient continuous homogeneous catalyst recycling.
authors: Department of Chemistry, U.G.C. Centre of Advance Studies in Chemistry, Guru Nanak Dev University , Amritsar 143005, India.
authors: Siddharth
authors: S
authors: Sharma
authors: K C
authors: KC
authors: Basavaraju
authors: Ajay K
authors: AK
authors: Singh
authors: Dong-Pyo
authors: DP
authors: Kim