title: Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes.
abstract: The endocannabinoid system (ECS) regulates multiple physiological processes, including cutaneous cell growth and differentiation. Here, we explored the effects of the major nonpsychotropic phytocannabinoid of Cannabis sativa, (-)-cannabidiol (CBD), on human sebaceous gland function and determined that CBD behaves as a highly effective sebostatic agent. Administration of CBD to cultured human sebocytes and human skin organ culture inhibited the lipogenic actions of various compounds, including arachidonic acid and a combination of linoleic acid and testosterone, and suppressed sebocyte proliferation via the activation of transient receptor potential vanilloid-4 (TRPV4) ion channels. Activation of TRPV4 interfered with the prolipogenic ERK1/2 MAPK pathway and resulted in the downregulation of nuclear receptor interacting protein-1 (NRIP1), which influences glucose and lipid metabolism, thereby inhibiting sebocyte lipogenesis. CBD also exerted complex antiinflammatory actions that were coupled to A2a adenosine receptor-dependent upregulation of tribbles homolog 3 (TRIB3) and inhibition of the NF-κB signaling. Collectively, our findings suggest that, due to the combined lipostatic, antiproliferative, and antiinflammatory effects, CBD has potential as a promising therapeutic agent for the treatment of acne vulgaris.
authors: Attila
authors: A
authors: Oláh
authors: Balázs I
authors: BI
authors: Tóth
authors: István
authors: I
authors: Borbíró
authors: Koji
authors: K
authors: Sugawara
authors: Attila G
authors: AG
authors: Szöllõsi
authors: Gabriella
authors: G
authors: Czifra
authors: Balázs
authors: B
authors: Pál
authors: Lídia
authors: L
authors: Ambrus
authors: Jennifer
authors: J
authors: Kloepper
authors: Emanuela
authors: E
authors: Camera
authors: Matteo
authors: M
authors: Ludovici
authors: Mauro
authors: M
authors: Picardo
authors: Thomas
authors: T
authors: Voets
authors: Christos C
authors: CC
authors: Zouboulis
authors: Ralf
authors: R
authors: Paus
authors: Tamás
authors: T
authors: Bíró
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy / Q000209:etiology; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002185:Cannabidiol / Q000494:pharmacology*; D048049:Extracellular Signal-Regulated MAP Kinases / Q000502:physiology; D006801:Humans; D050155:Lipogenesis / Q000187:drug effects; D012627:Sebaceous Glands / Q000166:cytology / Q000187:drug effects* / Q000473:pathology; D012629:Sebum / Q000502:physiology; D050916:TRPV Cation Channels / Q000502:physiology
chemical_list: D000893:Anti-Inflammatory Agents; D050916:TRPV Cation Channels; C416986:TRPV4 protein, human; D002185:Cannabidiol; D048049:Extracellular Signal-Regulated MAP Kinases