title: Gold(I)-catalyzed synthesis of optically active 1,4-oxazepan-7-ones.
abstract: Optically active seven-membered lactones, dimethyleneoxazepanones, were readily prepared in good yields from chiral β-(N-propargylic)amino-α-methylene carboxylic acid tert-butyl esters in the presence of catalytic amounts of Ph3PAuCl and Cu(OTf)2. A smooth 7-exo-dig cyclization was observed.
authors: Department of Applied Molecular Bioscience, Graduate School of Medicine, Yamaguchi University , Ube 755-8611, Japan.
authors: Akio
authors: A
authors: Kamimura
authors: Yu
authors: Y
authors: Yamane
authors: Ryuichiro
authors: R
authors: Yo
authors: Toshiyuki
authors: T
authors: Tanaka
authors: Hidemitsu
authors: H
authors: Uno
mesh_terms: D002384:Catalysis; D003500:Cyclization; D004952:Esters; D006046:Gold / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry*; D008698:Mesylates / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010077:Oxazepines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D004952:Esters; D007783:Lactones; D008698:Mesylates; D009942:Organometallic Compounds; D010077:Oxazepines; D006046:Gold; C012077:trifluoromethanesulfonic acid