title: Meta analysis of XRCC3 Thr241Met polymorphism and lung cancer susceptibility of populations in East Asia.
abstract: OBJECTIVE
  To assess the relation between XRCC3 Thr241Met polymorphism and lung cancer susceptibility of populations in East Asia.
  
  
  METHODS
  Related studies of XRCC3 Thr241Met polymorphism and lung cancer susceptibility of populations in East Asia were collected through searching the Pubmed, Embase Library, SPRINGER, CNKI and CSSCI.
  
  
  RESULTS
  According to the entry criteria, there were 8 case-control studies in the assessing system and there were 6 321 study cases, including 3 215 patients with lung cancer and 3 106 cases without cancers. Meta analysis results showed the combined OR value of the ratio of genotype Thr/Met+Met/Met and Thr/Thr was 1.03 (95%CI: 0.89-1.20) (P>0.05).
  
  
  CONCLUSIONS
  XRCC3 Thr241Met polymorphism may not related to lung cancer susceptibility of populations in East Asia. Allele 241Met did not increase the risk of lung cancer.
authors: Department of Thoracic Surgery, the Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors: Zhi-Song
authors: ZS
authors: Xing
authors: Department of Science and Education, the Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors: Guang
authors: G
authors: Zhu
authors: Department of Thoracic Surgery, the Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors: Yu-Lun
authors: YL
authors: Yang
authors: Department of Thoracic Surgery, the Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors: Guang-Qiang
authors: GQ
authors: Feng
authors: Department of Radiotherapy, the Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, China. Electronic address: guangchengding@163.com.
authors: Guang-Cheng
authors: GC
authors: Ding
mesh_terms: D004268:DNA-Binding Proteins / Q000235:genetics*; D005202:Asia, Eastern / Q000453:epidemiology; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; C110901:X-ray repair cross complementing protein 3
keywords: Lung cancer susceptibility; Meta analysis; Populations in East Asia; THr241Met; XRCC3