title: Preliminary pharmacological activity of the methanolic extract of Premna integrifolia barks in rats.
abstract: OBJECTIVE
  Premna integrifolia Linn (Family: Verbenaceae) synonym of Premna serratifolia has tremendous medicinal value. Preliminary pharmacological studies were performed on the methanolic extract of Premna integrifolia (MEPI) bark to investigate neuropharmacological, analgesic, and anti-inflammatory activities.
  
  
  METHODS
  Neuropharmacology study was done by open field and hole cross test whereas acetic acid writhing test and formalin induced pain was done for analgesic activity of MEPI. Carrageenan induced inflammatory model was considered for anti-inflammatory activity evaluation.
  
  
  RESULTS
  A statistically significant (p0.05) decrease in locomotor activity was observed at all doses in the open-field and hole-cross tests. The extract significantly (p0.05) and dose dependently reduced the writhing reflex in the acetic acid-induced writhing test as well as licking response in the formalin induced inflammatory pain. At 200 mg/kg body weight dose, MEPI showed 71.16% inhibition in carrageenan induced anti-inflammatory activity.
  
  
  CONCLUSIONS
  The finding of this study suggests that MEPI will provide scientific support for the use of this species in traditional medicine.
authors: Department of Pharmacy, Southeast University, Dhaka, Bangladesh.
authors: Hajera
authors: H
authors: Khatun
authors: Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh.
authors: Rajib
authors: R
authors: Majumder
authors: Department of Pharmacy, Rajshahi University, Rajshahi, Bangladesh.
authors: Al Mamun
authors: Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh.
authors: Efte Kharul
authors: EK
authors: Alam
authors: Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh ; Department of Pharmacy, University of Asia Pacific, Dhaka, Bangladesh.
authors: Safkath Ibne
authors: SI
authors: Jami
authors: Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh ; Department of Pharmacy, Jahangirnagar University, Savar, Dhaka, Bangladesh.
authors: Badrul
authors: B
authors: Alam
keywords: Analgesic; Antibacterial; CNS depressant; Inflammation; Premna integrifolia