title: Molluscum contagiosum in a pediatric American Indian population: incidence and risk factors.
abstract: BACKGROUND
  Molluscum contagiosum virus (MCV) causes an innocuous yet persistent skin infection in immunocompetent individuals and is spread by contact with lesions. Studies point to atopic dermatitis (AD) as a risk factor for MCV infection; however, there are no longitudinal studies that have evaluated this hypothesis.
  
  
  METHODS
  Outpatient visit data from fiscal years 2001-2009 for American Indian and Alaska Native (AI/AN) children were examined to describe the incidence of molluscum contagiosum (MC). We conducted a case-control study of patients <5 years old at an Indian Health Service (IHS) clinic to evaluate dermatological risk factors for infection.
  
  
  RESULTS
  The incidence rate for MC in children <5 years old was highest in the West and East regions. MC cases were more likely to have a prior or co-occurring diagnosis of eczema, eczema or dermatitis, impetigo, and scabies (p<0.05) compared to controls; 51.4% of MC cases had a prior or co-occurring diagnosis of eczema or dermatitis.
  
  
  CONCLUSIONS
  The present study is the first demonstration of an association between AD and MC using a case-control study design. It is unknown if the concurrent high incidence of eczema and MC is related, and this association deserves further investigation.
authors: Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America; Epidemic Intelligence Service, Scientific Education and Professional Development Program Office, US Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.
authors: Andrea M
authors: AM
authors: McCollum
authors: Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.
authors: Robert C
authors: RC
authors: Holman
authors: Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.
authors: Christine M
authors: CM
authors: Hughes
authors: Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.
authors: Jason M
authors: JM
authors: Mehal
authors: Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.
authors: Arianne M
authors: AM
authors: Folkema
authors: Division of Epidemiology and Disease Prevention, Office of Public Health Support, Indian Health Service, Albuquerque, New Mexico, United States of America.
authors: John T
authors: JT
authors: Redd
authors: Division of Epidemiology and Disease Prevention, Office of Public Health Support, Indian Health Service, Albuquerque, New Mexico, United States of America.
authors: James E
authors: JE
authors: Cheek
authors: Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.
authors: Inger K
authors: IK
authors: Damon
authors: Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.
authors: Mary G
authors: MG
authors: Reynolds
mesh_terms: D000553:Ambulatory Care / Q000706:statistics & numerical data; D016022:Case-Control Studies; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007198:Indians, North American; D007223:Infant; D008297:Male; D008976:Molluscum Contagiosum / Q000453:epidemiology*; D008977:Molluscum contagiosum virus; D016017:Odds Ratio; D012307:Risk Factors; D014481:United States / Q000453:epidemiology