title: Role of protease-activated receptors for the innate immune response of the heart.
abstract: Protease-activated receptors (PARs) are a family of G-protein-coupled receptors with a unique activation mechanism via cleavage by the serine proteases of the coagulation cascade, immune cell-released proteases, and proteases from pathogens. Pathogens, such as viruses and bacteria, cause myocarditis and heart failure and PAR1 was shown to positively regulate the anti-viral innate immune response via interferon β during virus-induced myocarditis. In contrast, PAR2 negatively regulated the innate immune response and inhibited the interferon β expression. Thus, PARs play a central role for the innate immune response in the heart.
authors: Department of Cardiology and Pneumology, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.
authors: Alice
authors: A
authors: Weithauser
authors: Department of Cardiology and Pneumology, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany. Electronic address: ursula.rauch@charite.de.
authors: Ursula
authors: U
authors: Rauch
mesh_terms: D006801:Humans; D007113:Immunity, Innate; D016899:Interferon-beta / Q000378:metabolism; D009205:Myocarditis / Q000276:immunology / Q000821:virology; D009206:Myocardium / Q000276:immunology*; D044462:Receptors, Proteinase-Activated / Q000378:metabolism*; D014777:Virus Diseases / Q000150:complications / Q000276:immunology
chemical_list: D044462:Receptors, Proteinase-Activated; D016899:Interferon-beta