title: Effects of Lys-Glu-Trp peptide on cell-cell interactions and vascular endothelium proliferation under normal conditions and during atherosclerosis.
abstract: The molecular mechanism of atherosclerosis is based on decreased expression of signal molecules connexin (Cx37 and Cx40), vascular endothelial growth factor (VEGF), and proliferative protein Ki-67, which characterize the processes of cell-cell interactions and proliferation of vascular endotheliocytes. Lys-Glu-Trp peptide in doses of 4 and 40 μg/ml promoted recovery of Cx37, Cx40, and VEGF expression in cultured endotheliocytes from the aorta of patients with atherosclerosis, which attests to vasoprotective effects of this agent.
authors: Tsitomed Biomedical Research-and-Production Complex, St. Petersburg, Russia.
authors: V V
authors: VV
authors: Malinin
authors: A O
authors: AO
authors: Durnova
authors: V O
authors: VO
authors: Polyakova
authors: I M
authors: IM
authors: Kvetnoi
mesh_terms: D050197:Atherosclerosis / Q000473:pathology*; D002450:Cell Communication / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D017630:Connexins / Q000378:metabolism; D042783:Endothelial Cells / Q000187:drug effects / Q000502:physiology*; D004730:Endothelium, Vascular / Q000473:pathology; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D009842:Oligopeptides / Q000494:pharmacology*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D000097003:Gap Junction alpha-5 Protein; D000097006:Gap Junction alpha-4 Protein
chemical_list: D017630:Connexins; D019394:Ki-67 Antigen; D009842:Oligopeptides; D042461:Vascular Endothelial Growth Factor A; D000097003:Gap Junction alpha-5 Protein; D000097006:Gap Junction alpha-4 Protein; C467484:VEGFA protein, human; C000596362:lysyl-glutamyl-tryptophan