title: Serologic survey on hantavirus in blood donors from the state of Santa Catarina, Brazil.
abstract: Emergent diseases such as Hantavirus Cardio-pulmonary Syndrome (HCPS) are able to create a significant impact on human populations due to their seriousness and high fatality rate. Santa Catarina, located in the South of Brazil, is the leading state for HCPS with 267 reported cases from 1999 to 2011. We present here a serological survey on hantavirus in blood donors from different cities of the state of Santa Catarina, with an IgG-ELISA using a recombinant nucleocapsid protein from Araraquara hantavirus as an antigen. In total, 314 donors from blood banks participated in the study, geographically covering the whole state. Among these, 14 individuals (4.4%) had antibodies to hantavirus: four of 50 (8% positivity) from Blumenau, four of 52 (7.6%) from Joinville, three of 50 (6%) from Florianópolis, two of 50 (4%) from Chapecó and one of 35 (2.8%) from Joaçaba. It is possible that hantaviruses are circulating across almost the whole state, with important epidemiological implications. Considering that the seropositive blood donors are healthy individuals, it is possible that hantaviruses may be causing unrecognized infections, which are either asymptomatic or clinically nonspecific, in addition to HCPS. It is also possible that more than one hantavirus type could be circulating in this region, causing mostly benign infections.
authors: Depto. de Ciências Farmacêuticas, Universidade de Blumenau, Blumenau, SC, Brazil.
authors: Caio Maurício Mendes de
authors: CM
authors: Cordova
authors: Centro de Pesquisa em Virologia. Ribeirão Preto, Faculdade de Medicina, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
authors: Luiz Tadeu Moraes
authors: LT
authors: Figueiredo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood; D001782:Blood Donors / Q000706:statistics & numerical data*; D001938:Brazil / Q000453:epidemiology; D021821:Communicable Diseases, Emerging / Q000453:epidemiology / Q000821:virology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006476:Orthohantavirus / Q000276:immunology*; D018778:Hantavirus Infections / Q000175:diagnosis / Q000453:epidemiology*; D018804:Hantavirus Pulmonary Syndrome / Q000453:epidemiology / Q000821:virology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G