title: Portable lactate analyzer for measuring lactate in cerebrospinal fluid (CSF) and plasma - method-comparison evaluations.
abstract: Increased plasma lactate levels can indicate the presence of metabolic disorders in HIV infected individuals.
  
  
  OBJECTIVE
  To determine whether a portable analyzer is valid for measuring cerebrospinal fluid (CSF) and plasma lactate levels in HIV infected individuals.
  
  
  METHODS
  CSF and plasma were collected from 178 subjects. Samples tested by the Accutrend portable analyzer were compared to those tested by a reference device (SYNCHRON LX 20).
  
  
  RESULTS
  The portable analyzer had in plasma sensitivity of 0.95 and specificity 0.87. For CSF the specificity was 0.95; the sensitivity 0.33; the negative predictive value was 95% and the positive predictive value 33%.
  
  
  CONCLUSIONS
  These findings support the validity of the portable analyzer in measuring lactate concentrations in CSF that fall within the normal range. The relatively poor positive predictive value indicates that a result above the reference range may represent a "false positive test", and should be confirmed by the reference device before concluding abnormality.
authors: Departments of Neurosciences, HIV Neurobehavioral Research Center, University of California, San Diego, USA.
authors: Sérgio Monteiro de
authors: SM
authors: Almeida
authors: Departments of Neurosciences, HIV Neurobehavioral Research Center, University of California, San Diego, USA.
authors: Jennifer
authors: J
authors: Marquie-Beck
authors: Departments of Psychiatry, HIV Neurobehavioral Research Center, University of California, San Diego, USA.
authors: Archana
authors: A
authors: Bhatt
authors: School of Medicine, HIV Neurobehavioral Research Center, University of California, San Diego, USA.
authors: Scott
authors: S
authors: Letendre
authors: School of Medicine, HIV Neurobehavioral Research Center, University of California, San Diego, USA.
authors: Allen
authors: A
authors: McCutchan
authors: Departments of Neurosciences, HIV Neurobehavioral Research Center, University of California, San Diego, USA.
authors: Ron
authors: R
authors: Ellis
mesh_terms: D000328:Adult; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000134:cerebrospinal fluid*; D006801:Humans; D019344:Lactic Acid / Q000097:blood* / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D019095:Point-of-Care Systems; D011237:Predictive Value of Tests; D012016:Reference Values; D015203:Reproducibility of Results; D013997:Time Factors
chemical_list: D019344:Lactic Acid