title: Regulating the diverse outcomes of interferon's interference.
abstract: Regulatory T cells are crucial for preventing autoimmunity, but how their function is restrained to allow optimal effector T cells responses in appropriate contexts is unclear. In a recent paper in the Journal of Experimental Medicine, Campbell and colleagues demonstrate that virus-induced type I interferon acts directly on Treg cells to allow for functional antiviral T cell responses.
authors: Department of Immunobiology, Yale University School of Medicine, New Haven 06520, CT, USA.
authors: Heather D
authors: HD
authors: Marshall
authors: Department of Immunobiology, Yale University School of Medicine, New Haven 06520, CT, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA. Electronic address: susan.kaech@yale.edu.
authors: Susan M
authors: SM
authors: Kaech
mesh_terms: D000818:Animals; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007108:Immune Tolerance; D007156:Immunologic Memory; D007370:Interferon Type I / Q000276:immunology*; D051379:Mice; D018345:Mice, Knockout; D050791:STAT Transcription Factors / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000821:virology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000821:virology; D014777:Virus Diseases / Q000276:immunology*
chemical_list: D007370:Interferon Type I; D050791:STAT Transcription Factors