title: [Trophoblast: conductor of the maternal immune tolerance].
abstract: Pregnancy is a temporary semi-allograft that survives for nine months. The importance of this event for the survival of the species justifies several tolerance mechanisms that are put into place at the beginning of pregnancy, some of which occur even at the time of implantation. The description of these mechanisms underlines the leadership of the trophoblast. The trophoblast is the conductor of the events, protects himself by expressing specific antigens and regulates the environment of the decidua according to the calendar of the events of the pregnancy The trophoblast and the decidual environment attract the effectors of immunity, almost all present in the decidua. The immunological atmosphere of the decidua evolves during the pregnancy modulating the level of activation of the immunological cells and adapting the level of activation to the stage of the pregnancy.
authors: Service de chirurgie gynécologique, département universitaire de gynécologie obstétrique, université Lille Nord de France, hôpital Jeanne-de-Flandre, CHRU de Lille, 59037 Lille cedex, France.
authors: V
authors: V
authors: Mesdag
authors: EA4550, IFR147, laboratoire de spectrométrie de masse biologique fondamentale et appliquée, université Lille Nord de France, université Lille 1, bâtiment SN3, 1(er) étage, 59655 Villeneuve d'Ascq cedex, France.
authors: M
authors: M
authors: Salzet
authors: Service de chirurgie gynécologique, département universitaire de gynécologie obstétrique, université Lille Nord de France, hôpital Jeanne-de-Flandre, CHRU de Lille, 59037 Lille cedex, France; EA4550, IFR147, laboratoire de spectrométrie de masse biologique fondamentale et appliquée, université Lille Nord de France, université Lille 1, bâtiment SN3, 1(er) étage, 59655 Villeneuve d'Ascq cedex, France. Electronic address: denis.vinatier@chru-lille.fr.
authors: D
authors: D
authors: Vinatier
mesh_terms: D000938:Antigen-Presenting Cells / Q000276:immunology; D000941:Antigens / Q000276:immunology; D003656:Decidua / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D010064:Embryo Implantation / Q000276:immunology; D005260:Female; D005333:Fetus / Q000276:immunology; D005865:Gestational Age; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D010920:Placenta / Q000276:immunology; D011247:Pregnancy; D013601:T-Lymphocytes / Q000276:immunology; D014327:Trophoblasts / Q000276:immunology*
chemical_list: D000941:Antigens
keywords: Immunologie; Immunology; Tolerance; Tolérance; Trophoblast; Trophoblaste