title: Effect of acupuncture on inflammatory cytokines expression of spastic cerebral palsy rats.
abstract: OBJECTIVE
  To To investigate the effect of acupuncture on the tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), nitric oxide synthase (NOS) content and muscular tension of spasticity cerebral palsy rat model.
  
  
  METHODS
  The rats with spastic cerebral palsy were randomly divided into the control group, model group and acupuncture group. After successful modeling, the muscular tension and the content of TNF-α, IL-6, CRP, NOS were measured.
  
  
  RESULTS
  The serum TNF-α, IL-6, CRP, NOS content were significantly decreased in the acupuncture group (P<0.05). The low and high shear viscosity of whole blood of the acupuncture group were significantly lower than the control group and the model group (P<0.05). The erythrocyte electrophoresis indexes in the acupuncture group were significantly lower than that in the model group and the control group (P<0.05). Acupuncture significantly reduced the muscular tension of spastic cerebral palsy rat and increased the active extent in the paralytic extremity (P<0.05), but it could not be restored to normal level. Compared with the control group, the difference had significant (P<0.05).
  
  
  CONCLUSIONS
  Acupuncture treatment can inhibit the release of inflammatory cells after brain injury, then reduce immune injury, relieve muscle spasms and reduce muscular tension.
authors: Department of Neurology, Hebei Provincial People's Hospital, Canzhou 050051, China.
authors: Ya-Chao
authors: YC
authors: Qi
authors: Department of Neurology, Hebei Provincial People's Hospital, Canzhou 050051, China.
authors: Xiang-Jian
authors: XJ
authors: Xiao
authors: Department of Neurology, Hebei Provincial People's Hospital, Canzhou 050051, China.
authors: Rui-Sheng
authors: RS
authors: Duan
authors: Department of Neurology, Hebei Provincial People's Hospital, Canzhou 050051, China.
authors: Yue-Hong
authors: YH
authors: Yue
authors: Department of Neurology, Hebei Provincial People's Hospital, Canzhou 050051, China.
authors: Xiao-Ling
authors: XL
authors: Zhang
authors: Department of Neurology, Hebei Provincial People's Hospital, Canzhou 050051, China.
authors: Jun-Tao
authors: JT
authors: Li
authors: Third Hospital of Hebei Medical University, Department of Pediatric Orthopaedics, Cangzhou, Hebei, China.
authors: Ya-Zhou
authors: YZ
authors: Li
mesh_terms: D015670:Acupuncture Therapy; D000818:Animals; D002547:Cerebral Palsy / Q000097:blood* / Q000628:therapy*; D016207:Cytokines / Q000097:blood*; D004195:Disease Models, Animal; D018056:Hemorheology / Q000502:physiology; D008297:Male; D009129:Muscle Tonus / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D016207:Cytokines
keywords: Acupuncture; Inflammatory factors; Muscular tension; Spastic cerebral palsy