title: EANO guideline for the diagnosis and treatment of anaplastic gliomas and glioblastoma.
abstract: This guideline provides recommendations for diagnostic and therapeutic procedures for patients with malignant gliomas. We differentiate evidence-based standards from reasonable options or non-evidence-based measures that should no longer be considered. The recommendations herein should provide a framework and assurance for the choice of diagnostic procedures and therapeutic measures and aim to reduce complications from unnecessary treatment and cost. The guideline contributes to a critical appreciation of concurrent drugs with a focus on the controlled use of anticonvulsants and steroids. It should serve as a guideline for all professionals involved in the diagnostics and care of glioma patients and also as a source of knowledge for insurance companies and other institutions involved in the cost regulation of cancer care in Europe. Implementation of the recommendations summarised here will need interdisciplinary structures of care for patients with brain tumours and structured processes of diagnostic and therapeutic procedures.
authors: Department of Neurology, University Hospital Zurich, Zurich, Switzerland. Electronic address: michael.weller@usz.ch.
authors: Michael
authors: M
authors: Weller
authors: Neurooncology Unit, Erasmus MC Cancer Institute, Rotterdam, Netherlands.
authors: Martin
authors: M
authors: van den Bent
authors: Bristol Haematology and Oncology Centre, Bristol, UK.
authors: Kirsten
authors: K
authors: Hopkins
authors: Department of Neurosurgery, University of Munich LMU, Munich, Germany.
authors: Jörg C
authors: JC
authors: Tonn
authors: Department of Oncology, University Hospital Zurich, Zurich, Switzerland.
authors: Roger
authors: R
authors: Stupp
authors: Department of Neuroradiology, Scientific Institute San Raffaele Hospital and University Vita-Salute San Raffaele, Milan, Italy.
authors: Andrea
authors: A
authors: Falini
authors: Département de Radiotherapie, Institut Claudius Regaud, Toulouse, France.
authors: Elizabeth
authors: E
authors: Cohen-Jonathan-Moyal
authors: Neurooncologie Adulte et Pédiatrique, Centre Léon Bérard, Lyon, France.
authors: Didier
authors: D
authors: Frappaz
authors: Regional Cancer Center Stockholm Gotland and Department of Radiation Sciences and Oncology, Umeå University Hospital, Sweden.
authors: Roger
authors: R
authors: Henriksson
authors: Catalan Institute of Oncology, Hospital Germans Trias i Pujol, Carretera Canyet sn, Badalona, Spain.
authors: Carmen
authors: C
authors: Balana
authors: Aix-Marseille Université, Department of Neuro-Oncology, CHU Timone, Marseilles, France.
authors: Olivier
authors: O
authors: Chinot
authors: Department of Neurosurgery, Tel Aviv Medical Center, Tel Aviv, Israel.
authors: Zvi
authors: Z
authors: Ram
authors: Department of Neuropathology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany; German Cancer Consortium, partner site Essen/Düsseldorf, Düsseldorf, Germany.
authors: Guido
authors: G
authors: Reifenberger
authors: Department of Neuro-Oncology, University Hospital, Turin, Italy.
authors: Riccardo
authors: R
authors: Soffietti
authors: Department of Neurooncology, Neurology Clinic & National Center for Tumor Diseases, University Hospital Heidelberg, Germany; German Consortium of Translational Cancer Research, Clinical Cooperation Unit Neurooncology, German Cancer Research Center, Heidelberg, Germany.
authors: Wolfgang
authors: W
authors: Wick
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy*; D003131:Combined Modality Therapy; D005060:Europe; D019317:Evidence-Based Medicine; D005260:Female; D005909:Glioblastoma / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy*; D005910:Glioma / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D018570:Risk Assessment; D012955:Societies, Medical; D016019:Survival Analysis