title: Daptomycin susceptibility of 833 strains of Gram-positive cocci from a university hospital in Japan (2009-2011).
abstract: The aim of this study was to confirm the daptomycin (DAP) susceptibility of bacteria isolated before the launch of DAP in Japan. DAP showed good activity against all 833 isolates (MIC90 = 0.25-0.5 mg/L for staphylococci, 0.5-4 mg/L for enterococci, and 0.25-0.5 mg/L for streptococci). This is the first report of the in vitro activity of DAP against Gram-positive cocci, including methicillin-resistant Staphylococcus aureus and enterococci, isolated in Japan.
authors: Department of Microbiology and Infectious Diseases, Toho University School of Medicine, Tokyo 143-8540, Japan.
authors: Ayumi
authors: A
authors: Yoshizumi
authors: Department of Microbiology and Infectious Diseases, Toho University School of Medicine, Tokyo 143-8540, Japan; Clinical laboratories Department, Toho University Medical Centre, Omori Hospital, Tokyo 143-8541, Japan. Electronic address: yishii@med.toho-u.ac.jp.
authors: Yoshikazu
authors: Y
authors: Ishii
authors: Clinical laboratories Department, Toho University Medical Centre, Omori Hospital, Tokyo 143-8541, Japan.
authors: Morihiro
authors: M
authors: Iwata
authors: Department of Microbiology and Infectious Diseases, Toho University School of Medicine, Tokyo 143-8540, Japan; Clinical laboratories Department, Toho University Medical Centre, Omori Hospital, Tokyo 143-8541, Japan.
authors: Hinako
authors: H
authors: Murakami
authors: Clinical laboratories Department, Toho University Medical Centre, Omori Hospital, Tokyo 143-8541, Japan.
authors: Shigeo
authors: S
authors: Yumoto
authors: Clinical laboratories Department, Toho University Medical Centre, Omori Hospital, Tokyo 143-8541, Japan.
authors: Kumiko
authors: K
authors: Yasui
authors: Clinical laboratories Department, Toho University Medical Centre, Omori Hospital, Tokyo 143-8541, Japan.
authors: Chikako
authors: C
authors: Maehara
authors: Clinical laboratories Department, Toho University Medical Centre, Omori Hospital, Tokyo 143-8541, Japan.
authors: Shigeru
authors: S
authors: Fukuzawa
authors: Clinical laboratories Department, Toho University Medical Centre, Omori Hospital, Tokyo 143-8541, Japan.
authors: Kyoko
authors: K
authors: Enokizono
authors: Department of Microbiology and Infectious Diseases, Toho University School of Medicine, Tokyo 143-8540, Japan; Clinical laboratories Department, Toho University Medical Centre, Omori Hospital, Tokyo 143-8541, Japan.
authors: Kazuhiro
authors: K
authors: Tateda
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017576:Daptomycin / Q000494:pharmacology*; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology; D006095:Gram-Positive Cocci / Q000187:drug effects* / Q000302:isolation & purification; D006785:Hospitals, University; D006801:Humans; D007564:Japan; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin
keywords: Antibiotic susceptibility; Daptomycin; Gram-positive cocci; MRSA