title: Prodigiosin release from an implantable biomedical device: kinetics of localized cancer drug release.
abstract: This paper presents an implantable encapsulated structure that can deliver localized heating (hyperthermia) and controlled concentrations of prodigiosin (a cancer drug) synthesized by bacteria (Serratia marcesce (subsp. marcescens)). Prototypical Poly-di-methyl-siloxane (PDMS) packages, containing well-controlled micro-channels and drug storage compartments, were fabricated along with a drug-storing polymer produced by free radical polymerization of Poly(N-isopropylacrylamide)(PNIPA) co-monomers of Acrylamide (AM) and Butyl-methacrylate (BMA). The mechanisms of drug diffusion of PNIPA-base gels were elucidated. Scanning Electron Microscopy (SEM) was also used to study the heterogeneous porous structure of the PNIPA-based gels. The release exponents, n, of the gels were found to between 0.5 and 0.7. This is in the range expected for Fickian (n=0.5). Deviation from Fickian diffusion was also observed (n>0.5) diffusion. The gel diffusion coefficients were shown to vary between 2.1×10(-12)m(2)/s and 4.8×10(-6)m(2)/s. The implications of the results are then discussed for the localized treatment of cancer via hyperthermia and the controlled delivery of prodigiosin from encapsulated PNIPA-based devices.
authors: Department of Materials Science and Engineering, African University of Science and Technology (AUST), Abuja, Federal Capital Territory, Nigeria.
authors: Y
authors: Y
authors: Danyuo
authors: Department of Materials Science and Engineering, African University of Science and Technology (AUST), Abuja, Federal Capital Territory, Nigeria.
authors: J D
authors: JD
authors: Obayemi
authors: Department of Materials Science and Engineering, African University of Science and Technology (AUST), Abuja, Federal Capital Territory, Nigeria.
authors: S
authors: S
authors: Dozie-Nwachukwu
authors: Department of Theoretical Physics, African University of Science and Technology (AUST), Abuja, Federal Capital Territory, Nigeria.
authors: C J
authors: CJ
authors: Ani
authors: Biotechnology and Genetic Engineering Advanced Laboratory, Sheda Science and Technology Complex (SHESTCO), Abuja, Federal Capital Territory, Nigeria.
authors: O S
authors: OS
authors: Odusanya
authors: Department of Chemistry, Bronx Community College, New York, NY, USA.
authors: Y
authors: Y
authors: Oni
authors: Department of Chemistry, Bronx Community College, New York, NY, USA; Princeton Institute for the Science and Technology of Materials (PRISM), 70 Prospect Street, Princeton, NJ 08544, USA.
authors: N
authors: N
authors: Anuku
authors: Department of Chemistry, Bronx Community College, New York, NY, USA.
authors: K
authors: K
authors: Malatesta
authors: Department of Materials Science and Engineering, African University of Science and Technology (AUST), Abuja, Federal Capital Territory, Nigeria; Princeton Institute for the Science and Technology of Materials (PRISM), 70 Prospect Street, Princeton, NJ 08544, USA; Department of Mechanical and Aerospace Engineering 1 Olden Street, Princeton, NJ 08544, USA. Electronic address: soboyejo@princeton.edu.
authors: W O
authors: WO
authors: Soboyejo
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D000970:Antineoplastic Agents / Q000737:chemistry / Q000493:pharmacokinetics*; D002626:Chemistry, Pharmaceutical / Q000295:instrumentation; D004058:Diffusion; D016503:Drug Delivery Systems / Q000295:instrumentation; D065546:Drug Liberation; D004358:Drug Therapy / Q000295:instrumentation*; D020100:Hydrogels / Q000737:chemistry; D006979:Hyperthermia, Induced; D007700:Kinetics; D011353:Prodigiosin / Q000737:chemistry / Q000493:pharmacokinetics*; D019736:Prostheses and Implants
chemical_list: D000180:Acrylic Resins; D000970:Antineoplastic Agents; D020100:Hydrogels; C052970:poly-N-isopropylacrylamide; D011353:Prodigiosin
keywords: Biomedical device; Breast cancer; Hyperthermia; Localized chemotherapy; Poly(N-Isopropylacrylamide)-based hydrogels; Prodigiosin