title: Molecular imaging in oncology: (18)F-sodium fluoride PET imaging of osseous metastatic disease.
abstract: OBJECTIVE
  This literature review details the history, pharmacokinetics, and utility of (18)F-sodium fluoride (Na(18)F) PET/CT in detecting osseous metastases compared with the current standard of care, technetium-99m methylene diphosphonate ((99m)Tc-MDP) bone scintigraphy. Additional discussion highlights solutions to impediments for broader implementation of this modality and insight into the complementary roles of (18)F-FDG PET/CT and Na(18)F PET/CT in oncology imaging, including preliminary data for combined Na(18)F and FDG PET/CT.
  
  
  CONCLUSIONS
  Na(18)F PET/CT is the most comprehensive imaging modality for the evaluation of osseous metastatic disease. Although further data acquisition is necessary to expand cost-benefit analyses of this imaging agent, emerging data reinforce its diagnostic advantage, suggest methods to mitigate impediments to broader utilization of Na(18)F PET/CT, and introduce a potentially viable technique for single-session combined Na(18)F and FDG PET/CT staging of soft-tissue and osseous disease.
authors: 1 All authors: Department of Radiology, University of Kansas Medical Center, 3901 Rainbow Blvd, Mail Stop 4032, Kansas City, KS 66160.
authors: Curtis G
authors: CG
authors: Mick
authors: Trent
authors: T
authors: James
authors: Jacqueline D
authors: JD
authors: Hill
authors: Patrick
authors: P
authors: Williams
authors: Mark
authors: M
authors: Perry
mesh_terms: D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D005462:Fluorine Radioisotopes / Q000493:pharmacokinetics; D006801:Humans; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D012969:Sodium Fluoride / Q000493:pharmacokinetics; D013669:Technetium Tc 99m Medronate / Q000493:pharmacokinetics
chemical_list: D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D012969:Sodium Fluoride; D013669:Technetium Tc 99m Medronate
keywords: PET; bone metastasis; cancer staging; oncology; sodium fluoride