title: Metastatic melanoma in association with a giant congenital melanocytic nevus in an adult: controversial CGH findings.
abstract: Giant congenital melanocytic nevi (GCMNs) represent a distress to patients for 2 reasons: one is disfigurement, and the other is the increased risk of developing secondary melanocytic tumors, such as benign proliferative nodules (BPNs) and malignant melanoma (MM). BPN present as a rapid growth nodule arising within a congenital melanocytic nevus (CMN) that often ulcerates, occurs in children younger than 2 years of age. BPNs arising within a CMN are exceedingly rare after childhood, and very few cases have been described in adults. Despite the worrisome clinical and histologic findings of BPN, most laboratory investigations seem to support their benignity. The distinction between MM and BPN is extremely important, but the histopathology of BPN of GCMN can be a challenge to differentiate from MM. In the recent years, molecular tests that investigate DNA copy number alterations such as fluorescence in situ hybridization and comparative genomic hybridization have shown promise to help guide the diagnosis of ambiguous melanocytic proliferations arising within CMNs. We report the case of a 22-year-old woman with a nodule arising in a GCMN and with an axillary mass suggesting a nodal metastasis of melanoma, and discuss the unusual clinical, histopathologic, and molecular findings that make this case particularly interesting.
authors: Departments of *Dermatology, and †Pathology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain; and ‡Departments of Dermatology and Pathology, and the UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA.
authors: Salma
authors: S
authors: Machan
authors: Ana M
authors: AM
authors: Molina-Ruiz
authors: Maria J
authors: MJ
authors: Fernández-Aceñero
authors: Beatriz
authors: B
authors: Encabo
authors: Philip
authors: P
authors: LeBoit
authors: Boris C
authors: BC
authors: Bastian
authors: Luis
authors: L
authors: Requena
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D055028:Comparative Genomic Hybridization; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008545:Melanoma / Q000235:genetics / Q000473:pathology*; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000473:pathology*; D009508:Nevus, Pigmented / Q000151:congenital / Q000235:genetics / Q000473:pathology*; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology*; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor