title: Delayed anemia after treatment with injectable artesunate in the Democratic Republic of the Congo: a manageable issue.
abstract: Cases of delayed hemolytic anemia have been described after treatment with injectable artesunate, the current World Health Organization (WHO)-recommended first-line drug for the treatment of severe malaria. A total of 350 patients (215 [61.4%] < 5 years of age and 135 [38.6%] ≥ 5 years of age) were followed-up after treatment with injectable artesunate for severe malaria in hospitals and health centers of the Democratic Republic of the Congo. Complete series of hemoglobin (Hb) measurements were available for 201 patients. A decrease in Hb levels between 2 and 5 g/dL was detected in 23 (11.4%) patients during the follow-up period. For five patients, Hb levels decreased below 5 g/dL during at least one follow-up visit. All cases of delayed anemia were clinically manageable and resolved within one month.
authors: Christian
authors: C
authors: Burri
authors: Giovanfrancesco
authors: G
authors: Ferrari
authors: Henry Maggi
authors: HM
authors: Ntuku
authors: Antoinette Tshefu
authors: AT
authors: Kitoto
authors: Stephan
authors: S
authors: Duparc
authors: Pierre
authors: P
authors: Hugo
authors: Didier Kalemwa
authors: DK
authors: Mitembo
authors: Christian
authors: C
authors: Lengeler
mesh_terms: D000743:Anemia, Hemolytic / Q000139:chemically induced* / Q000401:mortality; D000962:Antimalarials / Q000008:administration & dosage / Q000009:adverse effects*; D037621:Artemisinins / Q000008:administration & dosage / Q000009:adverse effects*; D000077332:Artesunate; D002648:Child; D002675:Child, Preschool; D015023:Democratic Republic of the Congo; D005500:Follow-Up Studies; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007223:Infant; D007275:Injections, Intravenous; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000469:parasitology; D010963:Plasmodium falciparum / Q000302:isolation & purification*; D013997:Time Factors
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D006454:Hemoglobins; D000077332:Artesunate