title: Altered Brain White Matter Integrity in Temporal Lobe Epilepsy: A TBSS Study.
abstract: OBJECTIVE
  The aim of this study is to explore the possible changed cerebral white matter regions in patients with temporal lobe epilepsy (TLE) using diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS).
  
  
  METHODS
  Twenty TLE patients and 22 age- and gender-matched normal controls were included in this study. Voxel-wise analyses of multiple diffusion metrics, including fractional anisotropy (FA) and mean diffusivity (MD) were performed with TBSS.
  
  
  RESULTS
  TLE patients exhibited significantly reduced FA in widespread white matter regions including bilateral limbic circuit, corpus callosum, thalamus, internal/external capsule, temporooccipital connections, frontotemporal connections; increase of MD was exhibited significantly almost in the left hemisphere. A significant decrease in global FA integrity was shown in epilepsy subjects compared to healthy controls. Furthermore, it exhibited a significant positive correlation between the disease duration and MD of whole brain.
  
  
  CONCLUSIONS
  TLE is associated with widespread abnormalities in cerebral white matter tracts and these changes may have important clinical consequences.
authors: Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, China.
authors: Zhenyin
authors: Z
authors: Liu
authors: Yong
authors: Y
authors: Xu
authors: Jie
authors: J
authors: An
authors: Junjing
authors: J
authors: Wang
authors: Xiangyuan
authors: X
authors: Yin
authors: Ruiwang
authors: R
authors: Huang
authors: Xiaofei
authors: X
authors: Lv
authors: Lina
authors: L
authors: Chen
authors: Wensheng
authors: W
authors: Wang
authors: Shijun
authors: S
authors: Qiu
mesh_terms: D000328:Adult; D000465:Algorithms; D001921:Brain / Q000473:pathology*; D056324:Diffusion Tensor Imaging / Q000379:methods*; D004833:Epilepsy, Temporal Lobe / Q000473:pathology*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D066127:White Matter / Q000473:pathology*
keywords: Temporal lobe epilepsy; tract based spatial statistics; white matter integrity