title: [Treatment of cognitive impairments in oncology: a review of longitudinal controlled studies].
abstract: Various studies highlight cognitive impairments in cancer patients. This paper proposes a review of longitudinal controlled studies evaluating the efficacy of interventions aiming to reduce these cognitive impairments. Longitudinal controlled studies evaluating the efficacy of interventions aiming to reduce cognitive impairments in adult cancer patients and published between 1993 and 2013 were identified, with the exception of studies that implied patients suffering from CNS tumor or metastasis. Pharmacological interventions (n = 11) suggested the positive impact of modafinil on memory and executive functions. Non-pharmacological interventions (n = 10) suggested the positive impact of cognitive revalidation and stimulation programs, psycho-education and meditation on several memory, attentional and executive objective as well as subjective functions. Non-pharmacological interventions show more significant cognitive benefits than pharmacological interventions. Some longitudinal controlled studies support the usefulness of interventions aiming to reduce cognitive impairments in cancer patients. Further studies should evaluate the effectiveness of programs combining technics aiming to reduce cognitive impairments and psychotherapeutic technics aiming to support patients' coping with illness.
authors: Université libre de Bruxelles, Faculté des Sciences psychologiques et de l'Éducation, avenue F.D. Roosevelt 50 (CP 191), B-1050 Bruxelles, Belgique, Université libre de Bruxelles, Institut Jules-Bordet, Bruxelles, Belgique.
authors: Cindy
authors: C
authors: Borghgraef
authors: Université libre de Bruxelles, Faculté des Sciences psychologiques et de l'Éducation, avenue F.D. Roosevelt 50 (CP 191), B-1050 Bruxelles, Belgique, Université libre de Bruxelles, Institut Jules-Bordet, Bruxelles, Belgique.
authors: Yves
authors: Y
authors: Libert
authors: Université de Liège, Faculté des Sciences psychologiques et de l'Éducation, Liège, Belgique.
authors: Anne-Marie
authors: AM
authors: Etienne
authors: Université libre de Bruxelles, Hôpital Érasme, Bruxelles, Belgique.
authors: Nicole
authors: N
authors: Delvaux
authors: Université Catholique de Louvain, Faculté de Médecine, Bruxelles, Belgique.
authors: Christine
authors: C
authors: Reynaert
authors: Université libre de Bruxelles, Faculté des Sciences psychologiques et de l'Éducation, avenue F.D. Roosevelt 50 (CP 191), B-1050 Bruxelles, Belgique, Université libre de Bruxelles, Institut Jules-Bordet, Bruxelles, Belgique.
authors: Darius
authors: D
authors: Razavi
mesh_terms: D000328:Adult; D001559:Benzhydryl Compounds / Q000627:therapeutic use; D016022:Case-Control Studies; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D003071:Cognition; D003072:Cognition Disorders / Q000209:etiology / Q000628:therapy*; D000068256:Darbepoetin alfa; D000077265:Donepezil; D004921:Erythropoietin / Q000031:analogs & derivatives / Q000627:therapeutic use; D004958:Estradiol / Q000627:therapeutic use; D056344:Executive Function; D005260:Female; D006801:Humans; D007189:Indans / Q000627:therapeutic use; D008137:Longitudinal Studies; D008297:Male; D019122:Meditation; D008774:Methylphenidate / Q000627:therapeutic use; D000077408:Modafinil; D009369:Neoplasms / Q000628:therapy*; D010880:Piperidines / Q000627:therapeutic use
chemical_list: D001559:Benzhydryl Compounds; D000697:Central Nervous System Stimulants; D007189:Indans; D010880:Piperidines; D004921:Erythropoietin; D000068256:Darbepoetin alfa; D008774:Methylphenidate; D004958:Estradiol; D000077265:Donepezil; D000077408:Modafinil
keywords: cancer; cognitive impairments; pharmacological interventions; revalidation