title: Prognostic impact of hepatectomy for patients with non-hepatitis B, non-hepatitis C hepatocellular carcinoma.
abstract: BACK GROUND/AIM: The purpose of the present study was to clarify the clinicopathological features of non-hepatitis B and -C (NBNC) hepatocellular carcinoma (HCC), the incidence of which has been increasing.
  
  
  METHODS
  Two hundred and eighty-four patients with HCC were classified into three groups according to viral hepatitis status, namely NBNC, hepatitis B, and hepatitis C. We compared the three groups and studied related risk factors.
  
  
  RESULTS
  Patients without cirrhosis who had increased number of platelets and diabetes mellitus, and a serum alpha-feto-protein (AFP) level <100 ng/dl were more common in the NBNC group. The cumulative survival and disease-free survival were better in the NBNC group than in the other groups. The tumor size and hepatitis B or C viral status were found to be independent risk factors of disease-free survival and the presence of multiple lesions was the only independent risk factor of survival.
  
  
  CONCLUSIONS
  Close follow-up of NBNC liver cirrhosis and early detection of NBNC-HCC can improve the prognosis after surgery.
authors: Division of Digestive Surgery, Department of Surgery, North Medical Center, Kyoto Prefectural University of Medicine, Kyoto, Japan Department of Surgery, North Medical Center, Kyoto Prefectural University of Medicine, Kyoto, Japan tochiai@koto.kpu-m.ac.jp.
authors: Toshiya
authors: T
authors: Ochiai
authors: Division of Digestive Surgery, Department of Surgery, North Medical Center, Kyoto Prefectural University of Medicine, Kyoto, Japan Department of Surgery, North Medical Center, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: Shinpei
authors: S
authors: Ogino
authors: Division of Digestive Surgery, Department of Surgery, North Medical Center, Kyoto Prefectural University of Medicine, Kyoto, Japan Department of Surgery, North Medical Center, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: Takeshi
authors: T
authors: Ishimoto
authors: Division of Digestive Surgery, Department of Surgery, North Medical Center, Kyoto Prefectural University of Medicine, Kyoto, Japan Department of Surgery, North Medical Center, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: Atsushi
authors: A
authors: Toma
authors: Division of Digestive Surgery, Department of Surgery, North Medical Center, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: Yusuke
authors: Y
authors: Yamamoto
authors: Division of Digestive Surgery, Department of Surgery, North Medical Center, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: Ryo
authors: R
authors: Morimura
authors: Division of Digestive Surgery, Department of Surgery, North Medical Center, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: Hisashi
authors: H
authors: Ikoma
authors: Division of Digestive Surgery, Department of Surgery, North Medical Center, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: Eigo
authors: E
authors: Otsuji
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000209:etiology / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D006498:Hepatectomy; D006510:Hepatitis B Antibodies / Q000097:blood; D018937:Hepatitis C Antibodies / Q000097:blood; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011379:Prognosis
chemical_list: D006510:Hepatitis B Antibodies; D018937:Hepatitis C Antibodies
keywords: Hepatocellular carcinoma; cirrhosis; non-hepatitis B non-hepatitis C; surgery; virus