title: [Vaccines as an approach to the immunocorrection in herpetic infections].
abstract: Development of vaccines for immunologic correction in herpetic infections is an important problem that raises a growing concern worldwide. The data on the experimental studies of the efficacy of an inactivated whole-virion vaccine against herpes simplex viruses types 1 and 2 (HSV-1 and -2) using an animal model are discussed. The results of the multiyear application of the vaccine to ophthalmology and dermatology practice are also presented. The results unambiguously show a high efficacy of the vaccine in the prevention of recurrences of the infections based on activation of specific T-cell response. A live vaccine against the varicella zoster virus (VZV) was developed for control of the infection in children. For the cytomegalovirus (CMV) infection in adults, inactivated whole-virion vaccines are at the stage of development. An important part of the study addresses a combined application of the inactivated vaccines with immunomodulators.
authors: I F
authors: IF
authors: Barinskiĭ
authors: L M
authors: LM
authors: Alimbarova
authors: A A
authors: AA
authors: Lazarenko
authors: F R
authors: FR
authors: Makhmudov
authors: O V
authors: OV
authors: Sergeev
mesh_terms: D000328:Adult; D000818:Animals; D005260:Female; D006558:Herpes Genitalis / Q000276:immunology* / Q000517:prevention & control*; D022301:Herpes Simplex Virus Vaccines / Q000276:immunology* / Q000627:therapeutic use*; D018259:Herpesvirus 1, Human / Q000276:immunology*; D018258:Herpesvirus 2, Human / Q000276:immunology*; D006801:Humans; D008297:Male
chemical_list: D022301:Herpes Simplex Virus Vaccines