title: Pathology and diagnosis of neuroendocrine tumors: lung neuroendocrine.
abstract: Neuroendocrine (NE) tumors of the lung include a spectrum from low-grade typical carcinoid (TC) and intermediate-grade atypical carcinoid (AC) to high-grade large cell neuroendocrine carcinoma (LCNEC) and small cell lung carcinoma (SCLC). Although NE lung tumors are frequently discussed together, as in this article, carcinoids are very different from high-grade SCLC and LCNEC. SCLC and LCNEC are found in heavy-smoking, older patients, whereas smoking is not strongly associated with carcinoid tumors. On a molecular level, SCLC and LCNEC have extensive genetic abnormalities, but there are few in TC and slightly more in AC.
authors: Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA. Electronic address: travisw@mskcc.org.
authors: William D
authors: WD
authors: Travis
mesh_terms: D018287:Carcinoma, Large Cell / Q000473:pathology*; D018288:Carcinoma, Small Cell / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology*; D018358:Neuroendocrine Tumors / Q000473:pathology*
keywords: Atypical carcinoid; Carcinoid; Large cell neuroendocrine carcinoma; Lung; Neuroendocrine; Neuroendocrine cell hyperplasia; Small cell carcinoma; Typical carcinoid