title: Pogo-like transposases have been repeatedly domesticated into CENP-B-related proteins.
abstract: The centromere is a chromatin region that is required for accurate inheritance of eukaryotic chromosomes during cell divisions. Among the different centromere-associated proteins (CENP) identified, CENP-B has been independently domesticated from a pogo-like transposase twice: Once in mammals and once in fission yeast. Recently, a third independent domestication restricted to holocentric lepidoptera has been described. In this work, we take advantage of the high-quality genome sequence and the wealth of functional information available for Drosophila melanogaster to further investigate the possibility of additional independent domestications of pogo-like transposases into host CENP-B related proteins. Our results showed that CENP-B related genes are not restricted to holocentric insects. Furthermore, we showed that at least three independent domestications of pogo-like transposases have occurred in metazoans. Our results highlight the importance of transposable elements as raw material for the recurrent evolution of important cellular functions.
authors: Institute of Evolutionary Biology (CSIC- Universitat Pompeu Fabra), Barcelona, Spain.
authors: Lidia
authors: L
authors: Mateo
authors: Institute of Evolutionary Biology (CSIC- Universitat Pompeu Fabra), Barcelona, Spain josefa.gonzalez@ibe.upf-csic.es.
authors: Josefa
authors: J
authors: González
mesh_terms: D000818:Animals; D051936:Centromere Protein B / Q000737:chemistry / Q000235:genetics*; D004251:DNA Transposable Elements; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics*; D029721:Drosophila Proteins / Q000737:chemistry / Q000235:genetics*; D004331:Drosophila melanogaster / Q000737:chemistry / Q000235:genetics*; D019143:Evolution, Molecular; D017344:Genes, Insect; D006801:Humans; D008958:Models, Molecular; D010802:Phylogeny; D017434:Protein Structure, Tertiary; D019895:Transposases / Q000737:chemistry / Q000235:genetics*
chemical_list: D051936:Centromere Protein B; D004251:DNA Transposable Elements; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D019895:Transposases; C117693:pogo-T protein, Drosophila
keywords: Drosophila; exaptation; functional domain; holocentric chromosomes; pogo