title: Sound-induced hyperpolarization of hippocampal neurons.
abstract: The hippocampus is involved in episodic memory, which is composed of subjective experiences in the multisensory world; however, little is known about the subthreshold membrane potential responses of individual hippocampal neurons to sensory stimuli. Using in-vivo whole-cell patch-clamp recordings from hippocampal CA1 neurons in awake mice, we found that almost all hippocampal neurons exhibited a hyperpolarization of 1-2 mV immediately after the onset of a sound. This large-scale hyperpolarization was unaffected by the duration or pitch of the tone. The response was abolished by general anesthesia and a surgical fimbria-fornix lesion.
authors: aLaboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo bCenter for Information and Neural Networks, National Institute of Information and Communication Technology, Osaka, Japan.
authors: Reimi
authors: R
authors: Abe
authors: Tetsuya
authors: T
authors: Sakaguchi
authors: Nobuyoshi
authors: N
authors: Matsumoto
authors: Norio
authors: N
authors: Matsuki
authors: Yuji
authors: Y
authors: Ikegaya
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000818:Animals; D056547:CA1 Region, Hippocampal / Q000502:physiology*; D008297:Male; D008564:Membrane Potentials / Q000502:physiology*; D008813:Mice, Inbred ICR; D009434:Neural Pathways / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D018408:Patch-Clamp Techniques; D013016:Sound; D013997:Time Factors