title: The dystroglycan: nestled in an adhesome during embryonic development.
abstract: Invertebrate and vertebrate development relies on complex processes that require many coordinated cell functions including cell adhesion, migration, proliferation and polarization. These processes depend on tissues and are spatio-temporally regulated by specific interactions between cells and between cells and the extracellular matrices. The dystroglycan, a transmembrane receptor that binds multiple extracellular matrix proteins, is expressed from oogenesis to organogenesis. There are increasing data suggesting that the axis, consisting of extracellular component-dystroglycan-cytoplasmic proteins, controls both the adhesion of cells to matrices as well as the transduction of signals coming from or directed to matrices. In this article, we review current advances leading to consider that the dystroglycan is a key protein nestled in an adhesome involved in mechanisms of cell adhesion during embryonic development.
authors: UPMC Sorbonne Universités, UMR CNRS 7622, Laboratoire de Biologie du Développement, 75252 Paris Cedex 05, France. Electronic address: valerie.bello@snv.jussieu.fr.
authors: Valérie
authors: V
authors: Bello
authors: UPMC Sorbonne Universités, UMR CNRS 7622, Laboratoire de Biologie du Développement, 75252 Paris Cedex 05, France.
authors: Nicole
authors: N
authors: Moreau
authors: UPMC Sorbonne Universités, UMR CNRS 7009, Laboratoire de Biologie du Développement de Villefranche-sur-mer, Observatoire Océanologique, 06230 Villefranche-sur-mer, France.
authors: Cathy
authors: C
authors: Sirour
authors: UPS CNRS UPR 3294, Neurobiologie et Développement, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.
authors: Magdalena
authors: M
authors: Hidalgo
authors: UPMC Sorbonne Universités, UMR CNRS 7622, Laboratoire de Biologie du Développement, 75252 Paris Cedex 05, France.
authors: Nicolas
authors: N
authors: Buisson
authors: UPMC Sorbonne Universités, UMR CNRS 7622, Laboratoire de Biologie du Développement, 75252 Paris Cedex 05, France. Electronic address: thierry.darribere@upmc.fr.
authors: Thierry
authors: T
authors: Darribère
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000502:physiology*; D049030:Dystroglycans / Q000378:metabolism*; D047108:Embryonic Development / Q000502:physiology*; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D016326:Extracellular Matrix Proteins; D049030:Dystroglycans
keywords: Adhesome; Development; Dystroglycan; Extracellular matrices