title: Synthesis of silica vesicles with controlled entrance size for high loading, sustained release, and cellular delivery of therapeutical proteins.
abstract: A rationally designed two-step synthesis of silica vesicles is developed with the formation of vesicular structure in the first step and fine control over the entrance size by tuning the temperature in the second step. The silica vesicles have a uniform size of ≈50 nm with excellent cellular uptake performance. When the entrance size is equal to the wall thickness, silica vesicles after hydrophobic modification show the highest loading amount (563 mg/g) towards Ribonuclease A with a sustained release behavior. Consequently, the silica vesicles are excellent nano-carriers for cellular delivery applications of therapeutical biomolecules.
authors: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia.
authors: Jun
authors: J
authors: Zhang
authors: Surajit
authors: S
authors: Karmakar
authors: Meihua
authors: M
authors: Yu
authors: Neena
authors: N
authors: Mitter
authors: Jin
authors: J
authors: Zou
authors: Chengzhong
authors: C
authors: Yu
mesh_terms: D002460:Cell Line; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008855:Microscopy, Electron, Scanning; D012259:Ribonuclease, Pancreatic / Q000008:administration & dosage*; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D012822:Silicon Dioxide; D012259:Ribonuclease, Pancreatic
keywords: cellular delivery; entrance sizes; silica vesicles; sustained release; therapeutic proteins