title: Use of therapeutic plasma exchange in children with thrombocytopenia-associated multiple organ failure in the Turkish thrombocytopenia-associated multiple organ failure network.
abstract: OBJECTIVE
  Thrombocytopenia-associated multiple organ failure can lead to high mortality in critically ill children, possibly related to consequences of thrombotic microangiopathy. Plasma exchange therapy may improve thrombotic microangiopathy. The purpose of this observational cohort study is to describe whether there is an association between use of plasma exchange therapy and outcome in the Turkish thrombocytopenia-associated multiple organ failure network.
  We performed a retrospective cohort analysis in patients with thrombocytopenia-associated multiple organ failure at three different PICUs comparing those who received plasma exchange (+) plus standard therapies with those who did not receive plasma exchange (-) and only received standard therapies.
  
  
  RESULTS
  Among 42 of the enrolled patients with thrombocytopenia-associated multiple organ failure, all had a primary or secondary sepsis diagnosis. Fifteen received plasma exchange therapy (PE [+] group) and 27 received standard medical treatment without plasma exchange (PE [-] group). The mean age was 17.69 months (8.24-54.22) in the PE (+) group and 13.46 months (6.47-20.55) in the PE (-) group. Age (p = 0.232), gender (p = 0.206), thrombocyte count (p = 0.09), Organ Failure Index score (p = 0.111), and pediatric logistic organ dysfunction score (p = 0.177) at admission were not statistically different between groups. The overall 28-day mortality was higher in the PE (-) group (70.37%) compared with the PE (+) group (26.67%) (univariate p = 0.006; multivariate controlling for pediatric logistic organ dysfunction, Organ Failure Index, Pediatric Risk of Mortality scores, and neurological failure p = 0.048). Length of stay was increased in the PE (+) group (p = 0.004).
  
  
  CONCLUSIONS
  The positive association found between use of plasma exchange therapy and improved survival supports the potential of this therapy in Turkish children with thrombocytopenia-associated multiple organ failure. The positive, although less so, associated treatment effect observed after controlling for illness severity provides further rationale for performing a randomized controlled trial in the pediatric Turkish thrombocytopenia-associated multiple organ failure network. Sample size calculations call for a 100-patient trial with a pre hoc interim analysis after enrollment of 50 patients with thrombocytopenia-associated multiple organ failure.
authors: 1Department of Pediatrics, Pediatric Intensive Care Unit, Bakirkoy Dr. Sadi Konuk Research and Training Hospital, Istanbul, Turkey. 2Department of Pediatrics, Pediatric Intensive Care Unit, Cukurova University Medical Faculty, Adana, Turkey. 3Department of Pediatrics, Pediatric Intensive Care Unit, Ankara University Medical Faculty, Ankara, Turkey. 4Pediatric Intensive Care Unit, Department of Pediatrics, Haseki Research and Training Hospital, Istanbul, Turkey. 5Department of Critical Care Medicine and Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA.
authors: Esra
authors: E
authors: Sevketoglu
authors: Dincer
authors: D
authors: Yildizdas
authors: Ozden Ozgur
authors: OO
authors: Horoz
authors: Hasan Serdar
authors: HS
authors: Kihtir
authors: Tanil
authors: T
authors: Kendirli
authors: Suleyman
authors: S
authors: Bayraktar
authors: Joseph A
authors: JA
authors: Carcillo
mesh_terms: D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007902:Length of Stay; D008297:Male; D009102:Multiple Organ Failure / Q000209:etiology / Q000628:therapy*; D010951:Plasma Exchange; D012189:Retrospective Studies; D018805:Sepsis / Q000150:complications; D015996:Survival Rate; D013921:Thrombocytopenia / Q000150:complications / Q000628:therapy*; D016896:Treatment Outcome; D014421:Turkey