title: Association between GUC2C and ADHD: evidence from both categorical and quantitative traits.
abstract: Guanylyl cyclase-C knock-out mice exhibit hyperactivity and attention deficits. We investigated seven single nucleotide polymorphisms (SNPs) of Guanylate cyclase 2C gene (GUC2C) in 381 ADHD trios and 382 healthy controls. Transmission disequilibrium tests (TDT), case-control studies and quantitative analyses indicated association between GUC2C with ADHD and its core symptoms.
authors: Peking University Sixth Hospital/Institute of Mental Health, Beijing 100191, China; Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing 100191, China.
authors: Lu
authors: L
authors: Liu
authors: Peking University Sixth Hospital/Institute of Mental Health, Beijing 100191, China; Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing 100191, China.
authors: Haimei
authors: H
authors: Li
authors: Peking University Sixth Hospital/Institute of Mental Health, Beijing 100191, China; Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing 100191, China.
authors: Yi
authors: Y
authors: Wang
authors: Peking University Sixth Hospital/Institute of Mental Health, Beijing 100191, China; Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing 100191, China.
authors: Li
authors: L
authors: Yang
authors: Peking University Sixth Hospital/Institute of Mental Health, Beijing 100191, China; Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing 100191, China. Electronic address: qianqiujin@bjmu.edu.cn.
authors: Qiujin
authors: Q
authors: Qian
authors: Peking University Sixth Hospital/Institute of Mental Health, Beijing 100191, China; Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing 100191, China. Electronic address: wangyf@bjmu.edu.cn.
authors: Yufeng
authors: Y
authors: Wang
mesh_terms: D000818:Animals; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D015810:Linkage Disequilibrium; D051379:Mice; D018345:Mice, Knockout; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide; D019655:Quantitative Trait, Heritable; D000074261:Receptors, Enterotoxin; D050705:Receptors, Guanylate Cyclase-Coupled / Q000235:genetics*; D018000:Receptors, Peptide / Q000235:genetics*
chemical_list: D018000:Receptors, Peptide; C000613654:GUCY2C protein, human; C000613655:Gucy2c protein, mouse; D000074261:Receptors, Enterotoxin; D050705:Receptors, Guanylate Cyclase-Coupled
keywords: Association; Attention-deficit/hyperactivity disorder; GUC2C