title: Zinc finger protein 185 is a liver metastasis-associated factor in colon cancer patients.
abstract: LIM domain proteins are involved in several fundamental biological processes, including cell lineage specification, cytoskeleton organization and organ development. Zinc finger protein 185 (ZNF185) is one of the LIM domain proteins considered to be involved in the regulation of cellular differentiation and/or proliferation. However, the detailed functions and properties of ZNF185 in the multistep process of cancer biology have not yet been elucidated. In this study, we analyzed the association between ZNF185 and the clinicopathological characteristics of colon cancer, such as patient age and gender, histological type, lymphatic and venous involvement, T and N status, liver metastasis and stage. ZNF185 protein expression was immunohistochemically analyzed and ZNF185 was detected in the cancer cells of 78 of the 87 colon cancer patients. The correlation between ZNF185 and histological type was significant (P=0.010, G-test). ZNF185 expression was also significantly correlated with liver metastasis (P=0.030, G-test). A multivariate analysis using the Cox proportional hazards model was performed among cause-specific survival rate, ZNF185 expression and clinicopathological characteristics. Histological type, liver metastasis and ZNF185 expression were found to be independent prognostic indicators (P=0.028, P<0.0001 and P=0.036, respectively). Therefore, ZNF185 expression was found to be an independent indicator of liver metastasis and prognosis in patients with colon cancer.
authors: Department of Surgery, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
authors: Daisuke
authors: D
authors: Furukawa
authors: Laboratory Animal Research Department, Central Institute for Experimental Animals, Kawasaki, Kanagawa 210-0821, Japan.
authors: Tsuyoshi
authors: T
authors: Chijiwa
authors: Department of Surgery, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
authors: Masahiro
authors: M
authors: Matsuyama
authors: Department of Surgery, Tokai University Hachioji Hospital, Hachioji, Tokyo 192-0032, Japan.
authors: Masaya
authors: M
authors: Mukai
authors: Global Application Development Center, Analytical and Measuring Instruments Division, Shimadzu Corporation, Kyoto 604-8511, Japan.
authors: Ei-Ichi
authors: EI
authors: Matsuo
authors: The Integrated Center for Mass Spectrometry, Graduate School of Medicine, Kobe University, Kobe, Hyogo 650-0017, Japan.
authors: Osamu
authors: O
authors: Nishimura
authors: Pathological Analysis Center, Central Institute for Experimental Animals, Kawasaki, Kanagawa 210-0821, Japan.
authors: Kenji
authors: K
authors: Kawai
authors: Laboratory Animal Research Department, Central Institute for Experimental Animals, Kawasaki, Kanagawa 210-0821, Japan.
authors: Hiroshi
authors: H
authors: Suemizu
authors: Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo 104-0045, Japan.
authors: Nobuyoshi
authors: N
authors: Hiraoka
authors: Department of Surgery, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
authors: Toshio
authors: T
authors: Nakagohri
authors: Department of Surgery, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
authors: Seiei
authors: S
authors: Yasuda
authors: Department of Regenerative Medicine, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
authors: Masato
authors: M
authors: Nakamura
keywords: colon cancer; liver metastasis; prognosis; zinc finger protein 185