title: Reinfection after successful eradication of Helicobacter pylori in three different populations in Alaska.
abstract: We performed a study to determine rates of reinfection in three groups followed for 2 years after successful treatment: American Indian/Alaska Native (AI/AN) persons living in urban (group 1) and rural (group 2) communities, and urban Alaska non-Native persons (group 3). We enrolled adults diagnosed with H. pylori infection based on a positive urea breath test (13C-UBT). After successful treatment was documented at 2 months, we tested each patient by 13C-UBT at 4, 6, 12 and 24 months. At each visit, participants were asked about medication use, illnesses and risk factors for reinfection. We followed 229 persons for 2 years or until they became reinfected. H. pylori reinfection occurred in 36 persons; cumulative reinfection rates were 14·5%, 22·1%, and 12·0% for groups 1, 2, and 3, respectively. Study participants who became reinfected were more likely to have peptic ulcer disease (P = 0·02), low education level (P = 0·04), or have a higher proportion of household members infected with H. pylori compared to participants who did not become reinfected (P = 0·03). Among all three groups, reinfection occurred at rates higher than those reported for other US populations (<5% at 2 years); rural AI/AN individuals appear to be at highest risk for reinfection.
authors: Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Emerging Zoonotic and Infectious Diseases,Centers for Disease Control and Prevention (CDC),Anchorage, Alaska,USA.
authors: M G
authors: MG
authors: Bruce
authors: Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Emerging Zoonotic and Infectious Diseases,Centers for Disease Control and Prevention (CDC),Anchorage, Alaska,USA.
authors: D L
authors: DL
authors: Bruden
authors: Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Emerging Zoonotic and Infectious Diseases,Centers for Disease Control and Prevention (CDC),Anchorage, Alaska,USA.
authors: J M
authors: JM
authors: Morris
authors: Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Emerging Zoonotic and Infectious Diseases,Centers for Disease Control and Prevention (CDC),Anchorage, Alaska,USA.
authors: A L
authors: AL
authors: Reasonover
authors: The Alaska Native Medical Center,Anchorage, Alaska,USA.
authors: F
authors: F
authors: Sacco
authors: Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Emerging Zoonotic and Infectious Diseases,Centers for Disease Control and Prevention (CDC),Anchorage, Alaska,USA.
authors: D
authors: D
authors: Hurlburt
authors: Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Emerging Zoonotic and Infectious Diseases,Centers for Disease Control and Prevention (CDC),Anchorage, Alaska,USA.
authors: T W
authors: TW
authors: Hennessy
authors: Liver Disease and Hepatitis Program, Division of Community Health Services,Alaska Native Tribal Health Consortium,Anchorage, Alaska,USA.
authors: J
authors: J
authors: Gove
authors: Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Emerging Zoonotic and Infectious Diseases,Centers for Disease Control and Prevention (CDC),Anchorage, Alaska,USA.
authors: A
authors: A
authors: Parkinson
authors: Internal Medicine Associate Inc., Anchorage,Alaska,USA.
authors: G
authors: G
authors: Sahagun
authors: The Alaska Native Medical Center,Anchorage, Alaska,USA.
authors: P
authors: P
authors: Davis
authors: Yukon Kuskokwim Health Corporation,Bethel, Alaska,USA.
authors: J
authors: J
authors: Klejka
authors: Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Emerging Zoonotic and Infectious Diseases,Centers for Disease Control and Prevention (CDC),Anchorage, Alaska,USA.
authors: B J
authors: BJ
authors: McMahon
mesh_terms: D000413:Alaska / Q000453:epidemiology; D004522:Educational Status; D005191:Family Characteristics; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology; D016480:Helicobacter pylori; D006801:Humans; D007198:Indians, North American / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012307:Risk Factors; D012424:Rural Population / Q000706:statistics & numerical data; D014505:Urban Population / Q000706:statistics & numerical data
keywords: reinfection