title: L-Rhamnose-containing supramolecular nanofibrils as potential immunosuppressive materials.
abstract: An l-rhamnose-based hydrogelator self-assembles to form nanofibrils, which, in contrast to the properties of monomeric l-rhamnose, suppress the antibody response of mice to phycoerythrin (PE), a fluorescent protein antigen. As the first example of the supramolecular assemblies of a saccharide to suppress immunity, this work illustrates a new approach of immunomodulation.
authors: Department of Chemistry, Brandeis University, 415 South St. MS015, Waltham, Massachusetts 02454, USA. bxu@brandeis.edu.
authors: Fan
authors: F
authors: Zhao
authors: Balthasar A
authors: BA
authors: Heesters
authors: Isaac
authors: I
authors: Chiu
authors: Yuan
authors: Y
authors: Gao
authors: Junfeng
authors: J
authors: Shi
authors: Ning
authors: N
authors: Zhou
authors: Michael C
authors: MC
authors: Carroll
authors: Bing
authors: B
authors: Xu
mesh_terms: D000276:Adjuvants, Immunologic / Q000737:chemistry; D000818:Animals; D000938:Antigen-Presenting Cells; D000941:Antigens / Q000737:chemistry; D004247:DNA / Q000737:chemistry; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry; D006020:Glycopeptides / Q000737:chemistry; D006801:Humans; D020100:Hydrogels / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007107:Immune System; D007074:Immunoglobulin G / Q000737:chemistry; D007075:Immunoglobulin M / Q000737:chemistry; D007166:Immunosuppressive Agents / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry; D051379:Mice; D008823:Micelles; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods; D010455:Peptides / Q000737:chemistry; D012210:Rhamnose / Q000737:chemistry*
chemical_list: D000276:Adjuvants, Immunologic; D000941:Antigens; D000939:Epitopes; D005456:Fluorescent Dyes; D006020:Glycopeptides; D020100:Hydrogels; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007166:Immunosuppressive Agents; D008081:Liposomes; D008823:Micelles; D010455:Peptides; D004247:DNA; D012210:Rhamnose