title: A 1st-trimester combined screening test in pregnant women of advanced maternal age in a Chinese population.
abstract: The purpose of this study was to evaluate the performance of the 1st-trimester combined screening test for trisomy 21 in different maternal age groups in a Chinese population. In this retrospective study, data on the 1st-trimester combined screening test (maternal age, fetal nuchal translucency, free β-human chorionic gonadotrophin, pregnancy-associated plasma protein-A) were analysed. The study population of 17,556 pregnant women was subdivided into three groups according to maternal age: 16,113 were < 35 years of age; 1,228 were 35-39 years of age; and 215 were ≥ 40 years of age. The detection and false-positive rates of the 1st-trimester screening test for trisomy 21 or trisomy 18 in the three groups of women were 89.5 and 1.7%; 90.9 and 6.8%; and 100 and 22.3%, respectively. With increasing maternal age, the odds of being affected given a positive result (OAPR) were increased. The balance between the detection rate and false-positive rate of the 1st-trimester combined screening test is more favourable in women < 36 years with comparable OAPR. Although the false-positive rate increases with increasing maternal age, the performance of the 1st-trimester combined screening test in women ≥ 35 years is more effective than screening based on maternal age alone.
authors: Prenatal Diagnostic Center, Guangzhou Women and Children Medical Center, Guangzhou Medical University , Guangzhou, Guangdong , China.
authors: M
authors: M
authors: Pan
authors: J
authors: J
authors: Han
authors: X
authors: X
authors: Yang
authors: L
authors: L
authors: Zhen
authors: C
authors: C
authors: Liao
authors: D Z
authors: DZ
authors: Li
mesh_terms: D000328:Adult; D002681:China; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood*; D002887:Chromosomes, Human, Pair 18; D004314:Down Syndrome / Q000175:diagnosis*; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008403:Mass Screening; D008423:Maternal Age; D008875:Middle Aged; D048208:Nuchal Translucency Measurement; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011266:Pregnancy-Associated Plasma Protein-A / Q000378:metabolism*; D012189:Retrospective Studies; D014314:Trisomy / Q000175:diagnosis*; D000073842:Trisomy 18 Syndrome
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human; D011266:Pregnancy-Associated Plasma Protein-A
keywords: 1st-trimester screening; Advanced maternal age; nuchal translucency; trisomy 21