title: Effects of short-chain fructooligosaccharides on faecal bifidobacteria and specific immune response in formula-fed term infants: a randomized, double-blind, placebo-controlled trial.
abstract: The aim of this study was to evaluate the effect of an infant formula supplemented with short-chain fructooligosaccharides (scFOS) on faecal concentration of bifidobacteria. Sixty-one healthy formula-fed infants participated in this double-blind controlled trial and were randomized to receive either the scFOS-supplemented formula (4 g/L scFOS) or the placebo-supplemented formula (4 g/L maltodextrins) until the age of 4 mo. Stool samples were analyzed for bifidobacteria at enrolment and at the age of 2 and 3 mo and for antipoliovirus IgA at the age of 4 mo. Parents completed a questionnaire to assess digestive tolerance. Change in faecal bifidobacteria after 2 mo were higher with scFOS compared to the placebo. At 4 mo, specific IgA tended to be higher with the scFOS group than with the placebo. Somatic growth and digestive tolerance were similar between groups. This study confirms that scFOS-supplemented formula can increase the concentration of faecal bifidobacteria while being well tolerated.
authors: Nutri-Health.
authors: Damien
authors: D
authors: Paineau
authors: Frédérique
authors: F
authors: Respondek
authors: Vincent
authors: V
authors: Menet
authors: Roland
authors: R
authors: Sauvage
authors: Francis
authors: F
authors: Bornet
authors: Anne
authors: A
authors: Wagner
mesh_terms: D000914:Antibodies, Viral / Q000737:chemistry; D001644:Bifidobacterium; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004041:Dietary Fats / Q000008:administration & dosage; D004044:Dietary Proteins / Q000008:administration & dosage; D004311:Double-Blind Method; D002149:Energy Intake; D005243:Feces / Q000737:chemistry / Q000382:microbiology*; D005260:Female; D005500:Follow-Up Studies; D005527:Food, Fortified; D006801:Humans; D007070:Immunoglobulin A / Q000737:chemistry; D041943:Infant Formula / Q000737:chemistry*; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D008297:Male; D009844:Oligosaccharides / Q000008:administration & dosage*; D023321:Poliovirus Vaccines / Q000627:therapeutic use
chemical_list: D000914:Antibodies, Viral; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D007070:Immunoglobulin A; D009844:Oligosaccharides; D023321:Poliovirus Vaccines; C116580:fructooligosaccharide