title: Comparison between effects of different doses of Melissa officinalis and atorvastatin on the activity of liver enzymes in hypercholesterolemia rats.
abstract: OBJECTIVE
  Liver is one of the most sensitive tissues to oxidant damage. Hence, the present study was conducted to compare the effects of Melissa officinalis (MO) extract and Atorvastatin on the activity of liver enzymes in rats.
  
  
  METHODS
  In this experimental study, 60 male Wistar rats were selected and allocated to six groups (n=10). The control group received a normal diet, sham group received a fatty diet while other groups received a fatty diet and the alcoholic extract of MO, at minimum (25 mg/kg), moderate (50 mg/kg), and maximum (75 mg/kg) doses (i.p.). The last group received Atorvastatin (10 mg/kg) through gavage with a fatty diet over a 21-day period. At the end of this 21-day period, blood samples were drawn and the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP), activity of liver enzymes as well as cholesterol in the samples were measured.
  
  
  RESULTS
  The obtained results showed that the activity of liver enzymes in the treatment groups receiving MO extract and the group receiving Atorvastatin decreased significantly. MO extract reduced the level of liver enzymes.
  
  
  CONCLUSIONS
  Therefore, further studies for obtaining a better understanding of the mechanism of effect of MO for treating liver diseases are recommended.
authors: Department of Biology, Unit of Science Research, Islamic Azad University of Damghan, Damghan, I.R. Iran.
authors: Ali
authors: A
authors: Zarei
authors: Department of Physiology, Arak University of Medical Sciences, Arak, I. R. Iran.
authors: Saeed
authors: S
authors: Changizi Ashtiyani
authors: , Arak University of Medical Sciences, Arak, I. R. Iran.
authors: Soheila
authors: S
authors: Taheri
authors: Department of Plant Biology, Payame-Noor University, Tehran, I. R. Iran.
authors: Fateme
authors: F
authors: Rasekh
keywords: Atorvastatin; Hypercholesterolemia; Melissa officinalis; Rat; liver enzyme