title: Evaluation of Melia azedarach extracts against Streptococcus mutans.
abstract: Although the incidence of caries worldwide has declined in recent years, it is necessary to search for new means to overcome this disease and its microbiological agents. Phytochemistry can become an effective alternative to antibiotics, offering a promising strategy in the prevention and therapy of dental caries. This study aimed to evaluate in vitro the bactericide activity of a bioactive phytocomponent from Melia azedarach against Streptococcus mutans. The crude extract (CEx) from leaves and stem barks of M. azedarach in chloroform, petroleum ether, acetate ethyl, butanol, and aqueous fractions was evaluated using seven different concentrations. Disk diffusion and minimum inhibitory concentration assays were used to evaluate the antibacterial activity. 0.12% chlorhexidine was used as a positive control. The CEx and the petroleum ether fraction from M. azedarach showed significant antibacterial activity against S. mutans, confirming its antibiotic potential.
authors: 1 Post-Graduate Program in Dentistry, Dental School, University of Passo Fundo , Passo Fundo, Brazil .
authors: Alvaro
authors: A
authors: Della Bona
authors: Fernanda
authors: F
authors: Nedel
mesh_terms: D000085:Acetates / Q000494:pharmacology; D000473:Alkanes / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000440:Butanols / Q000494:pharmacology; D002710:Chlorhexidine / Q000494:pharmacology; D002725:Chloroform / Q000494:pharmacology; D003731:Dental Caries / Q000188:drug therapy / Q000517:prevention & control; D031586:Melia azedarach / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D013295:Streptococcus mutans / Q000187:drug effects*
chemical_list: D000085:Acetates; D000473:Alkanes; D000900:Anti-Bacterial Agents; D000440:Butanols; D010936:Plant Extracts; C007650:ethyl acetate; D002725:Chloroform; C004544:naphtha; D002710:Chlorhexidine
keywords: M. azedarach; S. mutans; antibacterial activity; bioactive phytocomponents; caries