title: Knowledge discovery of drug data on the example of adverse reaction prediction.
abstract: BACKGROUND
  Antibiotics are the widely prescribed drugs for children and most likely to be related with adverse reactions. Record on adverse reactions and allergies from antibiotics considerably affect the prescription choices. We consider this a biomedical decision-making problem and explore hidden knowledge in survey results on data extracted from a big data pool of health records of children, from the Health Center of Osijek, Eastern Croatia.
  
  
  RESULTS
  We applied and evaluated a k-means algorithm to the dataset to generate some clusters which have similar features. Our results highlight that some type of antibiotics form different clusters, which insight is most helpful for the clinician to support better decision-making.
  
  
  CONCLUSIONS
  Medical professionals can investigate the clusters which our study revealed, thus gaining useful knowledge and insight into this data for their clinical studies.
authors: Pinar
authors: P
authors: Yildirim
authors: Ljiljana
authors: L
authors: Majnarić
authors: Ozgur
authors: O
authors: Ekmekci
authors: Andreas
authors: A
authors: Holzinger
mesh_terms: D000293:Adolescent; D000465:Algorithms; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002648:Child; D017523:Croatia / Q000453:epidemiology; D057225:Data Mining; D003657:Decision Making; D004358:Drug Therapy; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008490:Medical Informatics
chemical_list: D000900:Anti-Bacterial Agents