title: Relationship between EGFR over-expression and clinicopathologic characteristics in squamous cell carcinoma of the esophagus: a meta-analysis.
abstract: Over-expression of epidermal growth factor receptor (EGFR) has been identified as a common feature associated with clinical outcome in many types of cancer, including squamous cell carcinoma of the oesophagus (SCCO). However, the clinical importance of EGFR over-expression in SCCO remains unsettled as conflicting results exist. Therefore we carried out the present meta-analysis of published studies for clarification. A total of 13 studies including 1,150 patients were enrolled. EGFR over-expression was positive in 722 of these cases. With EGFR over-expression, patients had higher depth of invasion, vascular invasion, and poor prognosis. However, expression had no relation with degree of differentiation, histological grade, lymph node metastasis, clinical stage or lymphatic invasion. EGFR over-expression is probably a valuable predictor for the T stage, vascular invasion and OS, and it could be used as a poor prognosis indicator for the esophageal SCC patients. Targeting therapy to EFGR should be considered to the combined treatment in SCCO.
authors: Department of Radiation Oncology, the Fourth Hospital of HeBei Medical University, Shijiazhuang, China E-mail : wangjun90@aliyun.com.
authors: Jun
authors: J
authors: Wang
authors: Jin-Ming
authors: JM
authors: Yu
authors: Shao-Wu
authors: SW
authors: Jing
authors: Yin
authors: Y
authors: Guo
authors: Ya-Jing
authors: YJ
authors: Wu
authors: Na
authors: N
authors: Li
authors: Wen-Peng
authors: WP
authors: Jiao
authors: Li
authors: L
authors: Wang
authors: Yan-Jun
authors: YJ
authors: Zhang
mesh_terms: D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000473:pathology*; D066246:ErbB Receptors / Q000096:biosynthesis* / Q000235:genetics; D004938:Esophageal Neoplasms / Q000235:genetics / Q000473:pathology*; D000077277:Esophageal Squamous Cell Carcinoma; D004947:Esophagus / Q000473:pathology; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness / Q000235:genetics / Q000473:pathology*; D009367:Neoplasm Staging; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; C512478:EGFR protein, human; D066246:ErbB Receptors