title: Identification of a novel SEPT9-ABL1 fusion gene in a patient with T-cell prolymphocytic leukemia.
abstract: T-cell prolymphocytic leukemia (T-PLL), a rare type of peripheral T-cell leukemia, is characterized by marked splenomegaly with rapidly progressive lymphocytosis and a poor prognosis. Nine kinds of ABL1 chimeric genes have been identified in various kinds of hematological malignancies, such as chronic myeloid leukemia and B- or T-lymphoblastic leukemia. However, there have been no reports describing T-PLL cases with ABL1 rearrangements. We herein report a case of T-PLL with a novel SEPT9-ABL1 fusion gene which induced strong resistance to tyrosine kinase inhibitors such as imatinib and dasatinib.
authors: Division of Hematology/Oncology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan ; Division of Hematology, Ebina General Hospital, Ebina, Kanagawa, Japan.
authors: Rikio
authors: R
authors: Suzuki
authors: Department of Laboratory Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan ; Research Center for Cancer Stem Cell, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
authors: Hiromochi
authors: H
authors: Matsushita
authors: Division of Hematology/Oncology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan ; Research Center for Cancer Stem Cell, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
authors: Hidetsugu
authors: H
authors: Kawai
authors: Research Center for Cancer Stem Cell, Tokai University School of Medicine, Isehara, Kanagawa, Japan ; Teaching and Research Support Center, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
authors: Hideyuki
authors: H
authors: Matsuzawa
authors: Division of Hematology/Oncology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
authors: Kosuke
authors: K
authors: Tsuboi
authors: Division of Hematology, Ebina General Hospital, Ebina, Kanagawa, Japan.
authors: Shigeki
authors: S
authors: Watanabe
authors: Division of Hematology/Oncology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan ; Research Center for Cancer Stem Cell, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
authors: Hiroshi
authors: H
authors: Kawada
authors: Division of Hematology/Oncology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
authors: Yoshiaki
authors: Y
authors: Ogawa
authors: Division of Hematology/Oncology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan ; Research Center for Cancer Stem Cell, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
authors: Kiyoshi
authors: K
authors: Ando
keywords: SEPT9-ABL1; T-cell prolymphocytic leukemia; Tyrosine kinase inhibitors