title: Functional sperm testing and the role of proteomics in the evaluation of male infertility.
abstract: The limitations of conventional semen analysis testing in the diagnosis and management of male factor infertility have been well documented. A number of more sophisticated assays including measurements of sperm deoxyribonucleic acid (DNA) fragmentation rates, seminal oxidative stress, and antioxidant capacity have been increasingly used in the evaluation of male infertility. Moreover, in the past few years, tremendous advancements in the burgeoning field of sperm proteomics promise to revolutionize the andrologist's diagnostic armamentarium, as will be discussed in this review.
authors: Department of Urology and the Andrology Center, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH. Electronic address: barazay@ccf.org.
authors: Yagil
authors: Y
authors: Barazani
authors: Department of Urology and the Andrology Center, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH.
authors: Ashok
authors: A
authors: Agarwal
authors: Department of Urology and the Andrology Center, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH.
authors: Edmund S
authors: ES
authors: Sabanegh
mesh_terms: D053938:DNA Fragmentation; D006801:Humans; D007248:Infertility, Male / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D008297:Male; D018384:Oxidative Stress; D040901:Proteomics; D055101:Semen Analysis