title: Four new bis-iridoids isolated from the traditional Tibetan herb Pterocephalus hookeri.
abstract: Pterocenoids A-E (1-4), which Pterocenoids A(1) is one novel dimer containing a pyridine monoterpene alkaloid; and Pterocenoids B-E (2-4) are rare arranged non-glycosidic bis-iridoids were isolated from Pterocephlus hookeri. The structures of the compounds were established by 1D and 2D NMR spectroscopy and mass spectrometry. All bis-iridoids isolated from P. hookeri were found to possess secoiridoid/iridoid subtype skeletons. Hence, bis-iridoids can be regarded as the chemotaxonomic markers of P. hookeri. The origins of the new bis-iridoids (1-4) were postulated and their activities of inhibition of the NF-κB pathway were assayed and compounds 1-3 showed moderate activity in inhibiting NF-κB.
authors: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, PR China.
authors: Ying-Chun
authors: YC
authors: Wu
authors: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, PR China.
authors: Chen-Xu
authors: CX
authors: Guo
authors: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, PR China.
authors: Yuan-Zhang
authors: YZ
authors: Zhu
authors: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, PR China.
authors: Yi-Ming
authors: YM
authors: Li
authors: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, PR China. Electronic address: gfj@shutcm.edu.cn.
authors: Fu-Jiang
authors: FJ
authors: Guo
authors: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, PR China. Electronic address: gfz1998@163.com.
authors: Guo-Fu
authors: GF
authors: Zhu
mesh_terms: D027922:Caprifoliaceae / Q000737:chemistry*; D057809:HEK293 Cells; D006801:Humans; D039823:Iridoids / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D016328:NF-kappa B / Q000037:antagonists & inhibitors*
chemical_list: D039823:Iridoids; D016328:NF-kappa B
keywords: Bis-iridoid; Inhibition of NF-κB; Pterocephalus hookeri