title: Association of cardiometabolic risk profile with prehypertension accompany hyperhomocysteinaemia.
abstract: BACKGROUND
  Study suggested that elevated homocysteine showed a multiplicative effect on cardiovascular diseases in hypertensive subjects. It was reported that elevated homocysteine level was independently associated with increased arterial stiffness in prehypertensives. It remains unclear whether prehypertensives combined with elevated homocysteine have adverse cardiovascular risk factors. We aimed to compare cardiometabolic risk profile between prehypertensives with hyperhomocysteinaemia and those without either condition.
  
  
  METHODS
  Plasma total homocysteine and risk profile were determined among 874 Chinese non-hypertension individuals in Tianjin. They were subdivided into four groups: prehypertension with hyperhomocysteinaemia (≥10 μmol/L), prehypertension with normal homocysteine (<10 μmol/L), normotension with hyperhomocysteinaemia, normotension with normol homocysteine, respectively.
  
  
  RESULTS
  In 874 participants, 22.5% of them were male, mean age was 56.8 years. In multiple comparisons, after adjustment for age, gender, smoking, alcohol, exercise, education prehypertensives had higher body mass index (BMI) and high sensitive C reactive protein (hs-CRP) than normotensives (p < 0.05, respectively); Only prehypertensive subjects with hyperhomocysteinaemia had higher triglyceride and serum uric acid compared to normotensive subjects, and lower HDL cholesterol than normotensives with normal homocysteine (p < 0.05, respectively). However, the significance of higher hs-CRP, uric acid and lower HDL cholesterol were abolished when further adjustment was made for BMI.
  
  
  CONCLUSIONS
  The combination of prehypertension and hyperhomocusteinaemia increases the likelihood of having adverse cardiometabolic risk profile. Strict lipid management and weigh control may be needed in prehypertensives with elevated homocysteine.
authors: Department of Cardiology, Tianjin Medical University General Hospital , Tianjin , People's Republic of China.
authors: Huili
authors: H
authors: Chen
authors: Yuemin
authors: Y
authors: Sun
authors: Xuechun
authors: X
authors: Wang
authors: Quan
authors: Q
authors: Si
authors: Wei
authors: W
authors: Yao
authors: Zheng
authors: Z
authors: Wan
mesh_terms: D001794:Blood Pressure; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000378:metabolism / Q000517:prevention & control; D002681:China / Q000453:epidemiology; D050171:Dyslipidemias / Q000150:complications / Q000378:metabolism; D005260:Female; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications / Q000175:diagnosis / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D058246:Prehypertension / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism; D012307:Risk Factors
chemical_list: D002097:C-Reactive Protein
keywords: Hyperhomocysteinaemia; prehypertension; risk factor