title: Taxanes as a risk factor for acute adverse reactions to iodinated contrast media in cancer patients.
abstract: BACKGROUND
  The impact of cytotoxic agents on the risk of acute allergy-like adverse reactions (ARs) to intravenous iodinated contrast media (ICM) injections is unknown.
  
  
  METHODS
  We retrospectively reviewed 13,565 computed tomography (CT) scans performed in a consecutive cohort of cancer patients from January 1, 2010 to December 31, 2012. Episodes of acute ICM-related ARs were reported to the pharmacovigilance officer. The following matched comparisons were made: tax code, gender, primary tumor, antineoplastic therapy, and date of last cycle. Concomitant antineoplastic treatment was classified into five groups: platinum, taxane, platinum plus taxane, other, and no treatment group (no therapy had been administered in the previous 24 months). Logistic regression was used to estimate odds ratio (OR) and 95% confidence interval (CI) to evaluate the risk of acute ICM-related ARs.
  
  
  RESULTS
  Of 10,472 contrast-enhanced CT scans, 97 (0.93%; 95% CI: 0.74-1.11) ICM-related ARs were reported, 11 of which (0.1%) were severe, including one fatality. The overall incidence was significantly higher in patients aged <65 years (p = .0062) and in the platinum plus taxane and taxane groups (p = .007), whereas no correlation was found with gender, number of previous CT scans, site of disease, or treatment setting. Multivariate analysis confirmed an increased risk for patients aged <65 years (OR: 1.73; 95% CI: 1.14-2.63) and for the taxane group (in comparison with the no treatment group; OR: 2.06; 95% CI: 1.02-4.16).
  
  
  CONCLUSIONS
  Among cancer patients, concomitant treatment with taxanes and younger age would seem to be risk factors for ICM-related ARs.
authors: Department of Medical Oncology, Oncology Pharmacy Unit, Biostatistics and Clinical Trials Unit, IT Unit, Anesthesiology Unit, Cardiology Unit, and Radiology Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy.
authors: Alberto
authors: A
authors: Farolfi
authors: Department of Medical Oncology, Oncology Pharmacy Unit, Biostatistics and Clinical Trials Unit, IT Unit, Anesthesiology Unit, Cardiology Unit, and Radiology Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy.
authors: Corradina
authors: C
authors: Della Luna
authors: Department of Medical Oncology, Oncology Pharmacy Unit, Biostatistics and Clinical Trials Unit, IT Unit, Anesthesiology Unit, Cardiology Unit, and Radiology Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy.
authors: Angela
authors: A
authors: Ragazzini
authors: Department of Medical Oncology, Oncology Pharmacy Unit, Biostatistics and Clinical Trials Unit, IT Unit, Anesthesiology Unit, Cardiology Unit, and Radiology Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy.
authors: Elisa
authors: E
authors: Carretta
authors: Department of Medical Oncology, Oncology Pharmacy Unit, Biostatistics and Clinical Trials Unit, IT Unit, Anesthesiology Unit, Cardiology Unit, and Radiology Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy.
authors: Nicola
authors: N
authors: Gentili
authors: Department of Medical Oncology, Oncology Pharmacy Unit, Biostatistics and Clinical Trials Unit, IT Unit, Anesthesiology Unit, Cardiology Unit, and Radiology Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy.
authors: Carla
authors: C
authors: Casadei
authors: Department of Medical Oncology, Oncology Pharmacy Unit, Biostatistics and Clinical Trials Unit, IT Unit, Anesthesiology Unit, Cardiology Unit, and Radiology Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy.
authors: Michele
authors: M
authors: Aquilina
authors: Department of Medical Oncology, Oncology Pharmacy Unit, Biostatistics and Clinical Trials Unit, IT Unit, Anesthesiology Unit, Cardiology Unit, and Radiology Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy.
authors: Domenico
authors: D
authors: Barone
authors: Department of Medical Oncology, Oncology Pharmacy Unit, Biostatistics and Clinical Trials Unit, IT Unit, Anesthesiology Unit, Cardiology Unit, and Radiology Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy.
authors: Martina
authors: M
authors: Minguzzi
authors: Department of Medical Oncology, Oncology Pharmacy Unit, Biostatistics and Clinical Trials Unit, IT Unit, Anesthesiology Unit, Cardiology Unit, and Radiology Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy.
authors: Dino
authors: D
authors: Amadori
authors: Department of Medical Oncology, Oncology Pharmacy Unit, Biostatistics and Clinical Trials Unit, IT Unit, Anesthesiology Unit, Cardiology Unit, and Radiology Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy.
authors: Oriana
authors: O
authors: Nanni
authors: Department of Medical Oncology, Oncology Pharmacy Unit, Biostatistics and Clinical Trials Unit, IT Unit, Anesthesiology Unit, Cardiology Unit, and Radiology Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy giampaolo.gavelli@irst.emr.it.
authors: Giampaolo
authors: G
authors: Gavelli
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media / Q000009:adverse effects*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology / Q000473:pathology*; D005260:Female; D006801:Humans; D007455:Iodine / Q000009:adverse effects*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy / Q000453:epidemiology / Q000473:pathology*; D018570:Risk Assessment; D012307:Risk Factors; D015898:Tomography Scanners, X-Ray Computed / Q000009:adverse effects*
chemical_list: D003287:Contrast Media; D007455:Iodine
keywords: Cancer patients; Contrast-enhanced CT; Hypersensitivity; Iodinated contrast media; Risk of adverse event