title: T cell immunosurveillance controls B lymphoma development.
abstract: We recently showed a critical role for T cells in the immunosurveillance of nascent B cell lymphomas arising from mutations impacting plasma cell differentiation. Our data suggest that CD8+T cells continuously eliminate mutated B cells that fail to downregulate their co-stimulatory machinery and the Fas death receptor, thus constraining B lymphoma pathogenesis.
authors: The Walter and Eliza Hall Institute of Medical Research; Parkville, VIC Australia.
authors: Axel
authors: A
authors: Kallies
keywords: AID; Bcl6; CD8+ T cells; germinal center; immune surveillance; mutations