title: Dendritic cell-derived exosomes as immunotherapies in the fight against cancer.
abstract: Exosomes are nanometric membrane vesicles of late endosomal origin released by most, if not all, cell types as a means of sophisticated intercellular communication. A multitude of studies showed how exosomes can mediate and regulate immune responses against tumors. Dendritic cell-derived exosomes (Dex) have received much attention as immunotherapeutic anticancer agents since the discovery that they harbor functional MHC-peptide complexes, in addition to various other immune-stimulating components, that together facilitate immune cell-dependent tumor rejection. The therapeutic potential of Dex has been substantiated with their development and clinical testing in the treatment of cancer. This review focuses on mechanisms by which Dex interact with and influence immune cells and describes how they can be engineered to promote their immunogenic capacity as novel and dynamic anticancer agents.
authors: INSERM Unit U1015, Gustave Roussy Cancer Campus, 98405 Villejuif, France; Faculté de Médecine, Université Paris Sud-XI, 94276 Le Kremlin Bicêtre, France;
authors: Jonathan M
authors: JM
authors: Pitt
authors: INSERM Unit U1015, Gustave Roussy Cancer Campus, 98405 Villejuif, France; Faculté de Médecine, Université Paris Sud-XI, 94276 Le Kremlin Bicêtre, France;
authors: Mélinda
authors: M
authors: Charrier
authors: INSERM Unit U1015, Gustave Roussy Cancer Campus, 98405 Villejuif, France; Faculté de Médecine, Université Paris Sud-XI, 94276 Le Kremlin Bicêtre, France;
authors: Sophie
authors: S
authors: Viaud
authors: Faculté de Médecine, Université Paris Sud-XI, 94276 Le Kremlin Bicêtre, France; INSERM Unit U981, Gustave Roussy Cancer Campus, 98405 Villejuif, France; Department of Medical Oncology, Gustave Roussy Cancer Campus, 98405 Villejuif, France;
authors: Fabrice
authors: F
authors: André
authors: Faculté de Médecine, Université Paris Sud-XI, 94276 Le Kremlin Bicêtre, France; Department of Cancer Medicine, Gustave Roussy Cancer Campus, 98405 Villejuif, France; and.
authors: Benjamin
authors: B
authors: Besse
authors: INSERM Unit U1015, Gustave Roussy Cancer Campus, 98405 Villejuif, France; Faculté de Médecine, Université Paris Sud-XI, 94276 Le Kremlin Bicêtre, France;
authors: Nathalie
authors: N
authors: Chaput
authors: INSERM Unit U1015, Gustave Roussy Cancer Campus, 98405 Villejuif, France; Faculté de Médecine, Université Paris Sud-XI, 94276 Le Kremlin Bicêtre, France; Center of Clinical Investigations in Biotherapies of Cancer 507, Gustave Roussy Cancer Campus, 98405 Villejuif, France zitvogel@igr.fr.
authors: Laurence
authors: L
authors: Zitvogel
mesh_terms: D000818:Animals; D019496:Cancer Vaccines / Q000008:administration & dosage / Q000276:immunology; D002986:Clinical Trials as Topic / Q000379:methods; D003713:Dendritic Cells / Q000166:cytology* / Q000276:immunology* / Q000473:pathology; D004195:Disease Models, Animal; D055354:Exosomes / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D051379:Mice; D058990:Molecular Targeted Therapy / Q000379:methods; D009374:Neoplasms, Experimental / Q000276:immunology* / Q000473:pathology / Q000628:therapy*; D014407:Tumor Cells, Cultured
chemical_list: D019496:Cancer Vaccines