title: Prospects and perspectives for development of a vaccine against herpes simplex virus infections.
abstract: Herpes simplex viruses 1 and 2 are human pathogens that lead to significant morbidity and mortality in certain clinical settings. The development of effective antiviral medications, however, has had little discernible impact on the epidemiology of these pathogens, largely because the majority of infections are clinically silent. Decades of work have gone into various candidate HSV vaccines, but to date none has demonstrated sufficient efficacy to warrant licensure. This review examines developments in HSV immunology and vaccine development published since 2010, and assesses the prospects for improved immunization strategies that may result in an effective, licensed vaccine in the near future.
authors: Division of Pediatric Infectious Diseases and Immunology, University of Minnesota, 3-216 McGuire Translational Research Facility, 2001 6th Street S.E., Minneapolis, MN 55455, USA.
authors: Shane C
authors: SC
authors: McAllister
authors: Mark R
authors: MR
authors: Schleiss
mesh_terms: D055808:Drug Discovery / Q000639:trends; D006561:Herpes Simplex / Q000276:immunology / Q000517:prevention & control*; D022301:Herpes Simplex Virus Vaccines / Q000008:administration & dosage / Q000276:immunology* / Q000302:isolation & purification*; D006801:Humans; D018139:Simplexvirus / Q000276:immunology*; D014611:Vaccination / Q000379:methods*
chemical_list: D022301:Herpes Simplex Virus Vaccines
keywords: cell-mediated immunity; clinical trials; glycoprotein; herpes simplex; humoral immunity; latency; vaccination