title: Surface modification of polypropylene membrane by polyethylene glycol graft polymerization.
abstract: Polypropylene hollow fiber microporous membranes have been used in a wide range of applications, including blood oxygenator. The hydrophobic feature of the polypropylene surface causes membrane fouling. To minimize fouling, a modification consisting of three steps: surface activation in H2 and O2 plasma, membrane immersion in polyethylene glycol (PEG) and plasma graft polymerization was performed. The membranes were characterized by contact angle measurement, Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), tensile test, scanning electron microscopy (SEM) and atomic force microscopy (AFM). Oxygen transfer of modified membranes was also tested. The stability of grafted PEG was measured in water and in phosphate buffer saline (PBS) at 37°C. Blood compatibility of modified surfaces was evaluated by the platelet adhesion method. Water contact angel reduction from 110° to 72° demonstrates the enhanced hydrophilicity, and XPS results verify the presence of oxygenated functional groups due to the peak existence in 286 eV as a result of PEG grafting. The results clearly indicate that plasma graft-polymerization of PEG is an effective way for antifouling improvement of polypropylene membranes. Also, the results show that oxygen transfer changes in PEG grafted membranes are not significant.
authors: Department of Biomedical Engineering, Faculty of New Sciences and Technologies, University of Tehran, P.O. Box 14395-1561, Tehran, Iran. Electronic address: atiyeabednejad@gmail.com.
authors: Atiye Sadat
authors: AS
authors: Abednejad
authors: Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, P.O. Box 14395-1561, Tehran, Iran; Research Center for New Technologies in Life Science Engineering, University of Tehran, P.O. Box 63894-14179, Tehran, Iran.
authors: Ghasem
authors: G
authors: Amoabediny
authors: Department of Biomedical Engineering, Faculty of New Sciences and Technologies, University of Tehran, P.O. Box 14395-1561, Tehran, Iran.
authors: Azadeh
authors: A
authors: Ghaee
mesh_terms: D001672:Biocompatible Materials; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008422:Materials Testing; D008567:Membranes, Artificial; D010100:Oxygen / Q000032:analysis / Q000378:metabolism; D058626:Plasma Gases / Q000737:chemistry; D010973:Platelet Adhesiveness / Q000187:drug effects; D053657:Platelet-Rich Plasma / Q000166:cytology; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000633:toxicity; D058105:Polymerization; D011126:Polypropylenes / Q000737:chemistry* / Q000633:toxicity; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D008567:Membranes, Artificial; D058626:Plasma Gases; D011126:Polypropylenes; D011092:Polyethylene Glycols; D010100:Oxygen
keywords: Blood compatibility; Hydrophilicity; Plasma graft polymerization; Polyethylene glycol; Polypropylene