title: Intraoperative 3-D imaging improves sentinel lymph node biopsy in oral cancer.
abstract: OBJECTIVE
  The aim of this study was to prospectively evaluate the feasibility and potential advantages of freehand single-photon emission computed tomography (fhSPECT) compared with conventional intraoperative localization techniques for sentinel lymph node biopsy (SLNB) in oral cancer.
  
  
  METHODS
  Between November 2012 and February 2014, 23 consecutive patients with clinical T1/T2 oral squamous cell carcinoma and a cN0 neck were recruited. All patients underwent SLNB followed by elective neck dissection (END). All patients received preoperative lymphoscintigraphy. To detect the SLNs intraoperatively, fhSPECT with a combination of conventional acoustic SLN localization and 3-D visual navigation was used.
  
  
  RESULTS
  All but one of the SLNs detected by preoperative imaging were successfully mapped intraoperatively by fhSPECT (detection rate 98%), including those in six patients with a tumour in the floor of the mouth. A histopathology analysis revealed positive SLNs in 22% of patients. No further metastases were found in LNs resected during END. SLNB correctly predicted the final LN stage in all patients (accuracy 100%). Additional radioactive LNs, which were not present on preoperative lymphoscintigraphy, were observed in three patients.
  
  
  CONCLUSIONS
  FhSPECT is a feasible technology that allows the accurate identification of SLNs in oral cancer. FhSPECT overcomes the shine-through phenomenon, one of the most important limitations of SLNB, thereby confirming the importance of SLNB in patients with cN0 oral cancer.
authors: Department of Nuclear Medicine, University Hospital Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Germany.
authors: Christina
authors: C
authors: Bluemel
authors: Ken
authors: K
authors: Herrmann
authors: Alexander
authors: A
authors: Kübler
authors: Andreas K
authors: AK
authors: Buck
authors: Eva
authors: E
authors: Geissinger
authors: Vanessa
authors: V
authors: Wild
authors: Stefan
authors: S
authors: Hartmann
authors: Constantin
authors: C
authors: Lapa
authors: Christian
authors: C
authors: Linz
authors: Urs
authors: U
authors: Müller-Richter
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D021621:Imaging, Three-Dimensional; D007432:Intraoperative Period; D008198:Lymph Nodes / Q000000981:diagnostic imaging* / Q000473:pathology; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D021701:Sentinel Lymph Node Biopsy; D015899:Tomography, Emission-Computed, Single-Photon