title: Cyclical dehydration-induced renal injury and Mesoamerican nephropathy: as sweet by any other name?
abstract: Severe cyclical dehydration induces chronic renal injury in rodents. This effect is attenuated by global fructokinase deficiency, suggesting possible roles for fructokinase and fructose metabolism in mediating or promoting dehydration-induced injury. Clinical and pathological similarities between this injury model and endemic Mesoamerican nephropathy (MeN) have fueled speculation that dehydration-induced injury and MeN may share common mechanistic underpinnings involving fructokinase that can be targeted to mitigate disease development, progression, and/or severity.
authors: 1] Veterans Affairs Medical Center, White River Junction, Vermont, USA [2] Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
authors: R Brooks
authors: RB
authors: Robey
mesh_terms: D000818:Animals; D003681:Dehydration / Q000201:enzymology*; D005631:Fructokinases / Q000378:metabolism*; D007668:Kidney / Q000293:injuries*; D008297:Male
chemical_list: D005631:Fructokinases; C021475:ketohexokinase