title: [Age features of hemostatic system in people with insulin resistance and pre-diabetes carbohydrate metabolism disorders].
abstract: In pre-diabetes disorders in which pathogenesis the insulin resistance (IR) plays a leading role, the risk of thrombosis due to increased coagulation factors, decreased concentration of physiological anticoagulants and inhibition of fibrinolysis is increased. Similar changes in the hemostatic system with aging are observed. We investigated the characteristics of the hemostatic system in middle-aged and elderly people with IR in the absence and presence of impaired glucose tolerance (IGT). It is shown that IR in middle-aged and elderly people is accompanied by increased content of plasminogen activator inhibitor type-1, which may lead to potential inhibition of fibrinolysis. An indication of significant prothrombotic changes associated with IR in the elderly are reduced a clotting time of blood plasma in the APTT test and elevated levels of soluble fibrin and D-dimer. Intensity of these changes in the hemostatic system is enhanced in the presence of IGT. The results substantiate need for correction of hemostasis by reducing the IR.
authors: O V
authors: OV
authors: Korkushko
authors: E V
authors: EV
authors: Lugovskoĭ
authors: V B
authors: VB
authors: Shatilo
authors: I N
authors: IN
authors: Kolesnikova
authors: V A
authors: VA
authors: Ishchuk
authors: S S
authors: SS
authors: Naskalova
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000375:Aging / Q000378:metabolism*; D000933:Antifibrinolytic Agents / Q000097:blood; D001779:Blood Coagulation Factors; D001780:Blood Coagulation Tests / Q000379:methods; D001786:Blood Glucose; D050260:Carbohydrate Metabolism; D042241:Early Diagnosis; D005342:Fibrinolysis; D006487:Hemostasis; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000150:complications / Q000378:metabolism / Q000503:physiopathology; D013927:Thrombosis / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control
chemical_list: D000933:Antifibrinolytic Agents; D001779:Blood Coagulation Factors; D001786:Blood Glucose; D007328:Insulin