title: Efficacy and safety of topical eprinomectin to control Myocoptes musculinus infestation in mice.
abstract: Myocoptes musculinus is the most common fur mite identified among laboratory mice; infested mice, in addition to dermatological signs, may also be prone to secondary infections, affecting the outcome of a research trial. This trial was conducted in order to assess the safety and efficacy of a single topical administration of eprinomectin (5mg/kg BW) in a naturally infested laboratory mice colony. A safety trial was conducted on 20 uninfested pregnant females assigned to two groups, receiving eprinomectin and mineral oil, respectively. The mice were examined daily for signs of illness or toxicity; nests were individually weighted at 21 and 28 days postpartum. No acute toxicity was observed, all treated females gave full term delivery and number and mean weight of newborns ranged in the physiological values. To evaluate the efficacy, 20 naturally infested non-pregnant females were divided into two groups, treated as in the safety trial. Animals were observed daily for 15 min until 21 days post-treatment (DPT) and a "pruritus index" (PI: scratching and gnawing acts/mouse/min) was calculated. Pelage examination was performed on DPT 7, 14, 21 and 50. The "PI" was significantly lower in the treated group and mites were eradicated from all infested animals. A single topical administration of eprinomectin at a (high) dosage of 5mg/kg BW was safe and effective to control M. musculinus in mice.
authors: Dipartimento di Scienze Veterinarie, Scuola di Agraria e Medicina Veterinaria, Università di Torino ? UNITO, Grugliasco, Torino, Italy.
authors: Luisa
authors: L
authors: Rambozzi
authors: Dipartimento di Scienze Veterinarie, Scuola di Agraria e Medicina Veterinaria, Università di Torino ? UNITO, Grugliasco, Torino, Italy.
authors: Luca
authors: L
authors: Rossi
authors: Dipartimento di Scienze Veterinarie, Scuola di Agraria e Medicina Veterinaria, Università di Torino ? UNITO, Grugliasco, Torino, Italy.
authors: Anna Rita Molinar
authors: AR
authors: Min
authors: Dipartimento di Scienze Veterinarie, Scuola di Agraria e Medicina Veterinaria, Università di Torino ? UNITO, Grugliasco, Torino, Italy.
authors: Luca
authors: L
authors: Osella
authors: Dipartimento di Scienze Veterinarie, Scuola di Agraria e Medicina Veterinaria, Università di Torino ? UNITO, Grugliasco, Torino, Italy.
authors: Sergio
authors: S
authors: Bellardi
authors: Veterinary Practitioner, Caselle, Torino, Italy.
authors: Roberto
authors: R
authors: Marchetti
authors: Dipartimento di Scienze Veterinarie, Scuola di Agraria e Medicina Veterinaria, Università di Torino ? UNITO, Grugliasco, Torino, Italy.
authors: Paolo
authors: P
authors: Pollicino
mesh_terms: D000287:Administration, Topical; D000818:Animals; D005260:Female; D007306:Insecticides / Q000008:administration & dosage* / Q000009:adverse effects; D007559:Ivermectin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D051379:Mice / Q000469:parasitology*; D008924:Mite Infestations / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D007306:Insecticides; D007559:Ivermectin; C101434:eprinomectin