title: Functions of miR126 and innate immune response.
abstract: MicroRNAs (miRNAs) are endogenous non-coding small RNAs that negatively regulate gene expression at the post-transcriptional level by base pairing with target mRNAs. Many miRNAs have been proven to regulate a broad range of processes, including proliferation, differentiation, development and apoptosis. miR126 is encoded by intron 7 of the EGF- like domain 7 (Egfl7) gene and highly expressed in human endothelial cells (ECs) and plasmacytoid dendritic cells (pDCs). Based on the current knowledge, miR126 is involved in angiogenesis and cancer. Also miR126 is the first miRNA which has been reported to involve in preconditioning the responsiveness of the host to pathogen infection in the steady state. This implicated that miR126 may be the potential therapeutic target for cancer and autoimmune diseases. In this review, we summarize the functions of miR126 in angiogenesis and cancer, and emphasize its relationship with innate immune response.
authors: Institution of Genetics, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.
authors: Yu
authors: Y
authors: Bai
authors: Institution of Genetics, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.
authors: Wenyun
authors: W
authors: Lu
authors: Institution of Genetics, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.
authors: Ning
authors: N
authors: Han
authors: Institution of Genetics, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.
authors: Hongwu
authors: H
authors: Bian
authors: Institution of Genetics, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.
authors: Muyuan
authors: M
authors: Zhu
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D035683:MicroRNAs / Q000235:genetics / Q000276:immunology* / Q000627:therapeutic use; D009369:Neoplasms / Q000235:genetics / Q000276:immunology / Q000628:therapy
chemical_list: C527111:MIRN126 microRNA, human; D035683:MicroRNAs