title: Rapid on-site evaluation of endoscopic-ultrasound-guided fine-needle aspiration diagnosis of pancreatic masses.
abstract: Endoscopic ultrasound (EUS) has become an essential tool for the study of pancreatic diseases. Specifically, EUS plays a pivotal role evaluating patients with a known or suspected pancreatic mass. In this setting, differential diagnosis remains a clinical challenge. EUS-guided fine-needle aspiration (FNA) and fine-needle biopsy (FNB) have been proven to be safe and useful tools in this setting. EUS-guided FNA and FNB, by obtaining cytological and/or histological samples, are able to diagnose pancreatic lesions with high sensitivity and specificity. In this context, several methodological features, trying to increase the diagnostic yield of EUS-guided FNA and FNB, have been evaluated. In this review, we focus on the role of rapid on-site evaluation (ROSE). From data reported in the literature, ROSE may increase diagnostic yield of EUS-FNA specimens by 10%-30%, and thus, diagnostic accuracy. However, we should point out that many recent studies have reported adequacy rates of > 90% without ROSE, indicating that, perhaps, at high-volume centers, ROSE may not be indispensable to achieve excellent results. The use of ROSE can be considered important during the learning curve of EUS-FNA, and also in hospital with diagnostic accuracy rates < 90%.
authors: Julio Iglesias-Garcia, Jose Lariño-Noia, J Enrique Domínguez-Muñoz, Department of Gastroenterology and Hepatology, Foundation for Research in Digestive Diseases, University Hospital of Santiago de Compostela, 15706 Santiago de Compostela, Spain.
authors: Julio
authors: J
authors: Iglesias-Garcia
authors: Julio Iglesias-Garcia, Jose Lariño-Noia, J Enrique Domínguez-Muñoz, Department of Gastroenterology and Hepatology, Foundation for Research in Digestive Diseases, University Hospital of Santiago de Compostela, 15706 Santiago de Compostela, Spain.
authors: Jose
authors: J
authors: Lariño-Noia
authors: Julio Iglesias-Garcia, Jose Lariño-Noia, J Enrique Domínguez-Muñoz, Department of Gastroenterology and Hepatology, Foundation for Research in Digestive Diseases, University Hospital of Santiago de Compostela, 15706 Santiago de Compostela, Spain.
authors: Ihab
authors: I
authors: Abdulkader
authors: Julio Iglesias-Garcia, Jose Lariño-Noia, J Enrique Domínguez-Muñoz, Department of Gastroenterology and Hepatology, Foundation for Research in Digestive Diseases, University Hospital of Santiago de Compostela, 15706 Santiago de Compostela, Spain.
authors: J Enrique
authors: JE
authors: Domínguez-Muñoz
mesh_terms: D003937:Diagnosis, Differential; D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration; D006801:Humans; D010190:Pancreatic Neoplasms / Q000473:pathology*; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D013997:Time Factors
keywords: Diagnostic accuracy; Endoscopic-ultrasound-guided fine-needle aspiration; Rapid on-site evaluation; Solid pancreatic tumors