title: Hyalachelins A-C, unusual siderophores isolated from the terrestrial myxobacterium Hyalangium minutum.
abstract: Three new siderophores, termed hyalachelins A-C (1-3), were isolated from the terrestrial myxobacterium Hyalangium minutum. Their structures were determined by 2D NMR and HR-MS/MS experiments, and their stereochemical configuration was established by a combination of NMR data, quantum mechanical calculations, and circular dichroism experiments. Hyalachelins are unusual catecholate-type siderophores that bear a 3,7,8-trihydroxy-1-oxo-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid. Their iron chelating activities were evaluated in a CAS assay showing EC50 values of ∼30 μM.
authors: Department of Microbial Natural Products, Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Pharmaceutical Biotechnology, Saarland University , Campus C2 3, 66123 Saarbrücken, Germany.
authors: Suvd
authors: S
authors: Nadmid
authors: Alberto
authors: A
authors: Plaza
authors: Gianluigi
authors: G
authors: Lauro
authors: Ronald
authors: R
authors: Garcia
authors: Giuseppe
authors: G
authors: Bifulco
authors: Rolf
authors: R
authors: Müller
mesh_terms: D015394:Molecular Structure; D009231:Myxococcales / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D017262:Siderophores / Q000737:chemistry* / Q000302:isolation & purification*; D044005:Tetrahydroisoquinolines / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D017262:Siderophores; D044005:Tetrahydroisoquinolines; C000597787:hyalachelin A; C000597788:hyalachelin B; C000597789:hyalachelin C; C078986:1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid