title: Ultrasound interstitial thermal therapy (USITT) for the treatment of uterine myomas.
abstract: Uterine myomas (fibroids) are the most common pelvic tumors occurring in women, and are the leading cause of hysterectomy. Symptoms can be severe, and traditional treatments involve either surgical removal of the uterus (hysterectomy), or the fibroids (myomectomy). Interstitial ultrasound technologies have demonstrated potential for hyperthermia and high temperature thermal therapy in the treatment of benign and malignant tumors. These ultrasound devices offer favorable energy penetration allowing large volumes of tissue to be treated in short periods of time, as well as axial and angular control of heating to conform thermal treatment to a targeted tissue, while protecting surrounding tissues from thermal damage. The goal of this project is to evaluate interstitial ultrasound for controlled thermal coagulation of fibroids. Multi-element applicators were fabricated using tubular transducers, some of which were sectored to produce 180° directional heating patterns, and integrated with water cooling. Human uterine fibroids were obtained after routine myomectomies, and instrumented with thermocouples spaced at 0.5, 1.0, 1.5, 2.0, 2.5 and 3.0 cm from the applicator. Power levels ranging from 8-15 W per element were applied for up to 15 minute heating periods. Results demonstrated that therapeutic temperatures >50° C and cytotoxic thermal doses (t43) extended beyond 2 cm radially from the applicator (>4 cm diameter). It is anticipated that this system will make a significant contribution toward the treatment of uterine fibroids.
authors: Thermal Therapy Research Group, University of California, San Francisco, CA 94115.
authors: William H
authors: WH
authors: Nau
authors: Thermal Therapy Research Group, University of California, San Francisco, CA 94115.
authors: Chris J
authors: CJ
authors: Diederich
authors: Department of Anatomic Pathology, University of California, San Francisco, CA 94115.
authors: Jeff
authors: J
authors: Simko
authors: Thermal Therapy Research Group, University of California, San Francisco, CA 94115.
authors: Titania
authors: T
authors: Juang
authors: Department of Obstetrics and Gynecology, University of California, San Francisco, CA 94115.
authors: Alison
authors: A
authors: Jacoby
authors: Acoustic MedSystems, Inc., Champaign, IL 61820.
authors: E Clif
authors: EC
authors: Burdette
keywords: Thermal ablation; fibroids; leiomyomas; temperature; thermal dose