title: The Possibility of TBC1D21 as a Candidate Gene for Teat Numbers in Pigs.
abstract: Based on a quantitative traits locus (QTL) study using a F2 intercross between Landrace and Korean native pigs, a significant QTL affecting teat numbers in SSC7 was identified. The strong positional candidate gene, TBC1D21, was selected due to its biological function for epithelial mesenchymal cell development. Sequence analysis revealed six single nucleotide polymorphisms (SNPs) in the TBC1D21 gene. Among these, two SNP markers, one silent mutation (SNP01) for g.13,050A>G and one missense mutation (SNP04) for c.829A>T (S277C), were genotyped and they showed significant associations with teat number traits (p value = 6.38E-05 for SNP01 and p value = 1.06E-07 for SNP04 with total teat numbers). Further functional validation of these SNPs could give valuable information for understanding the teat number variation in pigs.
authors: Department of Animal Science and Biotechnology, Chungnam National University, Deajeon 305-764, Korea.
authors: S
authors: S
authors: Jin
authors: Department of Animal Science and Biotechnology, Chungnam National University, Deajeon 305-764, Korea.
authors: J B
authors: JB
authors: Lee
authors: Department of Animal Science and Biotechnology, Chungnam National University, Deajeon 305-764, Korea.
authors: K
authors: K
authors: Kang
authors: Department of Animal Science and Biotechnology, Chungnam National University, Deajeon 305-764, Korea.
authors: C K
authors: CK
authors: Yoo
authors: Department of Animal Science and Biotechnology, Chungnam National University, Deajeon 305-764, Korea.
authors: B M
authors: BM
authors: Kim
authors: Department of Animal Science and Biotechnology, Chungnam National University, Deajeon 305-764, Korea.
authors: H B
authors: HB
authors: Park
authors: Department of Animal Science and Biotechnology, Chungnam National University, Deajeon 305-764, Korea.
authors: H T
authors: HT
authors: Lim
authors: Department of Animal Science and Biotechnology, Chungnam National University, Deajeon 305-764, Korea.
authors: I C
authors: IC
authors: Cho
authors: Department of Animal Science and Biotechnology, Chungnam National University, Deajeon 305-764, Korea.
authors: D
authors: D
authors: Maharani
authors: Department of Animal Science and Biotechnology, Chungnam National University, Deajeon 305-764, Korea.
authors: J H
authors: JH
authors: Lee
keywords: Pig; QTL; SNP; SSC7; TBC1D21; Teat Number