title: Blood loses it when nerves go bad.
abstract: Myeloproliferative neoplasms are diseases that arise in the stem cells of the blood. In a recent paper published in Nature, Arranz et al. demonstrated that abrogation of sympathetic nerve fibers reduced bone marrow Nestin mesenchymal cells, which in turn led to an expansion of hematopoietic stem cells and progression of myeloproliferative neoplasms.
authors: 1] Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA [2] Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA [3] Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
authors: Ninib
authors: N
authors: Baryawno
authors: 1] Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA [2] Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA [3] Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
authors: David T
authors: DT
authors: Scadden
mesh_terms: D000818:Animals; D005260:Female; D006412:Hematopoietic Stem Cells / Q000473:pathology*; D006801:Humans; D009196:Myeloproliferative Disorders / Q000473:pathology*; D009369:Neoplasms / Q000473:pathology*; D009412:Nerve Fibers / Q000473:pathology*; D055153:Stem Cell Niche; D013564:Sympathetic Nervous System / Q000473:pathology*