title: Effect of emulsification-diffusion parameters on the formation of poly (3-hydroxybutyrate-co-3-hydroxyvalerate) particles.
abstract: The aim of this work was to evaluate the effect of various production parameters on the formation and particle size of poly (3-hydroxybutyrate-co-3-hydroxyvalerate) PHBV particles prepared by the emulsification-diffusion technique. The increase in homogenization time and speed caused a decrease in particle size. No particle formation was observed below 2% (w/v) PHBV in the organic phase. Smaller particle size and narrower size distribution were observed when polyvinyl alcohol (PVA) was used as a stabilizer, when compared to didodecyldimethylammonium bromide. Submicron particles of 531 ± 150 nm size were obtained with 2% (w/v) PVA at 17 500 rpm and 15 min homogenization conditions with dichloromethane as the organic solvent.
authors: a Department of Chemical Engineering , Faculty of Engineering, Ankara University , Ankara , Turkey.
authors: Eda
authors: E
authors: Göz
authors: a Department of Chemical Engineering , Faculty of Engineering, Ankara University , Ankara , Turkey.
authors: Ayşe
authors: A
authors: Karakeçili
mesh_terms: D000818:Animals; D002417:Cattle; D004058:Diffusion; D004339:Drug Compounding; D065546:Drug Liberation; D004655:Emulsions; D007700:Kinetics; D008752:Methylene Chloride / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry*; D011142:Polyvinyl Alcohol / Q000737:chemistry; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D000094122:Polyhydroxybutyrates
chemical_list: D004655:Emulsions; D008752:Methylene Chloride; D011091:Polyesters; D011142:Polyvinyl Alcohol; D000644:Quaternary Ammonium Compounds; D012710:Serum Albumin, Bovine; C052620:poly(3-hydroxybutyrate)-co-(3-hydroxyvalerate); D000094122:Polyhydroxybutyrates; C046112:didodecyldimethylammonium
keywords: PHBV; biodegradable polymers; emulsification-diffusion; polymeric particles