title: Malonyldialdehyde and glyoxal act differently on low-density lipoproteins and endotheliocytes.
abstract: Under some pathological conditions, the natural dicarbonyl compounds can accumulate in the blood. The examples are malonyldialdehyde (MDA) formed as a secondary product of lipid peroxidation of unsaturated fatty acids during atherosclerosis, and glyoxal (GOX), a homolog of MDA, which accumulates during glucose autoxidation in patients with diabetes mellitus. This study compared the influence of both dicarbonyl compounds on low-density lipoproteins (LDL) and the membrane of endotheliocytes. In comparison with GOX, MDA induced more pronounced changes in physical and chemical properties of LDL particles. On the other hand, GOX-modified LDL particles were more prone to oxidation and aggregation than MDA-modified LDL. Incubation of endotheliocytes with MDA increased cell mechanical stiffness in contrast to incubation with GOX, which decreased it.
authors: Russian Cardiology Research Center, 3rd Cherepkovskaya Str., 15A, Moscow, 121552, Russia, elena.kumskova@gmail.com.
authors: Elena M
authors: EM
authors: Kumskova
authors: Olga A
authors: OA
authors: Antonova
authors: Sergey A
authors: SA
authors: Balashov
authors: Alla K
authors: AK
authors: Tikhaze
authors: Arthur M
authors: AM
authors: Melkumyants
authors: Vadim Z
authors: VZ
authors: Lankin
mesh_terms: D002462:Cell Membrane / Q000187:drug effects; D002478:Cells, Cultured; D004587:Electrophoresis, Agar Gel; D042783:Endothelial Cells / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D004730:Endothelium, Vascular / Q000166:cytology; D006037:Glyoxal / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008054:Lipid Peroxides / Q000737:chemistry; D008077:Lipoproteins, LDL / Q000097:blood / Q000737:chemistry*; D008315:Malondialdehyde / Q000737:chemistry / Q000494:pharmacology*; D012212:Rheology / Q000379:methods
chemical_list: D008054:Lipid Peroxides; D008077:Lipoproteins, LDL; D008315:Malondialdehyde; D006037:Glyoxal