title: Duodenal bulb histological analysis should be standard of care when evaluating celiac disease in children.
abstract: We confirmed the added value provided by sampling D1 in the diagnosis of CD in comparison to the diagnosis yield when only the more distal duodenum (D2, D3, and/or D4) was sampled. The severity of CD, as assessed by the Marsh-Oberhuber classification, did not increase distally; on the contrary, in 39/60 (65%) of the cohort, the features of CD were either more severe or only present in D1.
authors: 1  Department of Histopathology, Sheffield Children's Hospital, Sheffield, United Kingdom.
authors: Sonja
authors: S
authors: Mansfield-Smith
authors: Vidyanand
authors: V
authors: Savalagi
authors: Nagendra
authors: N
authors: Rao
authors: Mike
authors: M
authors: Thomson
authors: Marta C
authors: MC
authors: Cohen
mesh_terms: D000293:Adolescent; D001284:Atrophy; D001706:Biopsy; D002446:Celiac Disease / Q000145:classification / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D004386:Duodenum / Q000473:pathology*; D005260:Female; D006801:Humans; D007223:Infant; D007413:Intestinal Mucosa / Q000473:pathology*; D008297:Male