title: Coat as a dagger: the use of capsid proteins to perforate membranes during non-enveloped DNA viruses trafficking.
abstract: To get access to the replication site, small non-enveloped DNA viruses have to cross the cell membrane using a limited number of capsid proteins, which also protect the viral genome in the extracellular environment. Most of DNA viruses have to reach the nucleus to replicate. The capsid proteins involved in transmembrane penetration are exposed or released during endosomal trafficking of the virus. Subsequently, the conserved domains of capsid proteins interact with cellular membranes and ensure their efficient permeabilization. This review summarizes our current knowledge concerning the role of capsid proteins of small non-enveloped DNA viruses in intracellular membrane perturbation in the early stages of infection.
authors: Department of Genetics and Microbiology, Faculty of Science, Charles University in Prague, Vinicna 5, 12844, Prague 2, Czech Republic. bilkove@natur.cuni.cz.
authors: Eva
authors: E
authors: Bilkova
authors: Department of Genetics and Microbiology, Faculty of Science, Charles University in Prague, Vinicna 5, 12844, Prague 2, Czech Republic. jitka.forstova@natur.cuni.cz.
authors: Jitka
authors: J
authors: Forstova
authors: Department of Genetics and Microbiology, Faculty of Science, Charles University in Prague, Vinicna 5, 12844, Prague 2, Czech Republic. levon.abrahamyan@natur.cuni.cz.
authors: Levon
authors: L
authors: Abrahamyan
mesh_terms: D000256:Adenoviridae / Q000502:physiology; D036022:Capsid Proteins / Q000737:chemistry / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism / Q000821:virology*; D002467:Cell Nucleus / Q000378:metabolism / Q000821:virology; D011992:Endosomes / Q000378:metabolism / Q000821:virology; D005057:Eukaryotic Cells / Q000378:metabolism / Q000821:virology*; D054884:Host-Pathogen Interactions; D006801:Humans; D027383:Papillomaviridae / Q000502:physiology; D010321:Parvoviridae / Q000502:physiology; D027382:Polyomaviridae / Q000502:physiology; D011485:Protein Binding; D021381:Protein Transport; D011991:Receptors, Virus / Q000378:metabolism; D053586:Virus Internalization; D014779:Virus Replication
chemical_list: D036022:Capsid Proteins; D011991:Receptors, Virus