title: The emerging role of speckle-type POZ protein (SPOP) in cancer development.
abstract: Speckle-type POZ (pox virus and zinc finger protein) protein (SPOP) is an E3 ubiquitin ligase adaptor protein that is frequently mutated in prostate and endometrial cancers. All the cancer-associated SPOP mutations reported to date are clustered in the meprin and TRAF (Tumor necrosis factor receptor-associated factor) homology (MATH) domain, presumably affecting substrate binding. SPOP mutations in prostate cancer are mutually exclusive with the ETS (Erythroblast transformation-specific) family gene rearrangements and define a distinct molecular subclass of prostate cancer. SPOP mutations contribute to prostate cancer development by altering the steady-state levels of key components in the androgen-signaling pathway.
authors: Department of Pathology, UT Southwestern Medical Center, Dallas, TX, USA; Department of Urology, UT Southwestern Medical Center, Dallas, TX, USA. Electronic address: ram.mani@utsouthwestern.edu.
authors: Ram-Shankar
authors: RS
authors: Mani
mesh_terms: D000728:Androgens / Q000378:metabolism; D000818:Animals; D016889:Endometrial Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D008297:Male; D009154:Mutation; D009687:Nuclear Proteins / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology; D012097:Repressor Proteins / Q000235:genetics*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D000728:Androgens; D009687:Nuclear Proteins; D012097:Repressor Proteins; C509761:SPOP protein, human