title: Low-heat treated autograft versus allograft for intercalary reconstruction of malignant bone tumors.
abstract: BACKGROUND
  Low-heat treated autograft may have an advantage over allograft in that they provide a size-matched and biologically compatible graft.
  
  
  METHODS
  We compared the graft survival and complications between the low-heat treated autografts (n = 13) and allografts (17) for intercalary reconstruction of malignant bone tumors. Average age was 25 years with follow-up of 6.6 years (1.8-12.5). For low-heat treatment, the resected bone was treated in saline at 65°C for 30 min. Nineteen grafts were fixed with plates and 13 with intramedullary nails.
  
  
  RESULTS
  Until last follow-up, five low-heat treated autografts (38%) and one allograft (6%) had been removed, with allografts showing a trend toward better survival on Kaplan-Meier analysis (P = 0.293). Complications were more common in low-heat treated autograft group [10/13 (77%) vs. 8/17 (47%), P = 0.098)]. Low-heat-treated autograft resulted in significantly higher rate of nonunion [11/26 (42%) vs. 5/34 (15%), P = 0.017] and required higher number of operations to treat nonunion (P = 0.004). Rates of graft fracture [3/13 (23%) vs. 2/17 (12%), P = 0.713)] or infection [2/13 (15%) vs. 1/17 (6%), P = 0.565)] were similar.
  
  
  CONCLUSIONS
  Our data suggest that intercalary allograft has better survival and fewer complications than the low-heat treated autograft.
authors: Department of Orthopaedic Surgery, Seoul National University Hospital, Seoul, Korea.
authors: Ilkyu
authors: I
authors: Han
authors: June Hyuk
authors: JH
authors: Kim
authors: Hwan-Seong
authors: HS
authors: Cho
authors: Han-Soo
authors: HS
authors: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D064591:Allografts; D064592:Autografts; D001859:Bone Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D016025:Bone Transplantation / Q000379:methods*; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006358:Hot Temperature; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D019651:Plastic Surgery Procedures; D015996:Survival Rate; D055815:Young Adult
keywords: allograft; intercalary; low-heat treated autograft; nonunion; survival