title: AGE metabolites: a biomarker linked to cancer disparity?
abstract: Socioeconomic and environmental influences are established factors promoting cancer disparity, but the contribution of biologic factors is not clear. We report a mechanistic link between carbohydrate-derived metabolites and cancer that may provide a biologic consequence of established factors of cancer disparity. Glycation is the nonenzymatic glycosylation of carbohydrates to macromolecules, which produces reactive metabolites called advanced glycation end products (AGE). A sedentary lifestyle and poor diet all promote disease and the AGE accumulation pool in our bodies and also increase cancer risk. We examined AGE metabolites in clinical specimens of African American and European American patients with prostate cancer and found a higher AGE concentration in these specimens among African American patients when compared with European American patients. Elevated AGE levels corresponded with expression of the receptor for AGE (RAGE or AGER). We show that AGE-mediated increases in cancer-associated processes are dependent upon RAGE. Aberrant AGE accumulation may represent a metabolic susceptibility difference that contributes to cancer disparity.
authors: Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina.
authors: Dion
authors: D
authors: Foster
authors: Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina.
authors: Laura
authors: L
authors: Spruill
authors: Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina.
authors: Katherine R
authors: KR
authors: Walter
authors: Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina.
authors: Lourdes M
authors: LM
authors: Nogueira
authors: Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina.
authors: Hleb
authors: H
authors: Fedarovich
authors: Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina.
authors: Ryan Y
authors: RY
authors: Turner
authors: Department of Biological and Physical Sciences, South Carolina State University, Orangeburg, South Carolina.
authors: Mahtabuddin
authors: M
authors: Ahmed
authors: Department of Biological and Physical Sciences, South Carolina State University, Orangeburg, South Carolina.
authors: Judith D
authors: JD
authors: Salley
authors: Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina.
authors: Marvella E
authors: ME
authors: Ford
authors: Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina. Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina.
authors: Victoria J
authors: VJ
authors: Findlay
authors: Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina. Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina. turnerda@musc.edu.
authors: David P
authors: DP
authors: Turner
mesh_terms: D001741:Black or African American; D014408:Biomarkers, Tumor / Q000032:analysis*; D004797:Enzyme-Linked Immunosorbent Assay; D005455:Fluorescent Antibody Technique; D017127:Glycation End Products, Advanced / Q000032:analysis* / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D011471:Prostatic Neoplasms / Q000208:ethnology / Q000378:metabolism*; D044465:White People
chemical_list: D014408:Biomarkers, Tumor; D017127:Glycation End Products, Advanced