title: Clinical features associated with ictal osmophobia in migraine.
abstract: Olfactory hypersensitivity may occur during migraine attacks and has been found to be very specific for this form of headache. Aim of this study was to investigate if migraineurs with ictal osmophobia have particular clinical features comparing to patients without ictal osmophobia. We recruited 200 consecutive migraineurs. Other primary headaches comorbidity and migraine prophylaxis were exclusion criteria. Each patient was interviewed following a structured questionnaire including general features about migraine, depression and anxiety symptoms. Migraine triggers both spontaneously and selecting from a specific list. Allodynia during the migraine attack was measured using the Allodynia symptoms check-list 12 (ASC-12). Eighty four (42 %) patients are non-osmophobic vs. 116 patients (58 %) who are osmophobic. After a logistic regression analysis, pain intensity (OR 1.391; p = 0.008) and anxiety (OR 1.099; p = 0.047) were significantly higher while aura (OR 0.421; p = 0.028) is less frequent in osmophobic migraineurs. We found significant differences in clinical features of osmophobic patients in respect to non-osmophobic ones. Ictal osmophobia seems being related to a broader sensorial hypersensitivity that could lead to a more florid clinical presentation.
authors: Neurology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 67, Pisa, Italy.
authors: Filippo
authors: F
authors: Baldacci
authors: Cinzia
authors: C
authors: Lucchesi
authors: Martina
authors: M
authors: Ulivi
authors: Martina
authors: M
authors: Cafalli
authors: Marcella
authors: M
authors: Vedovello
authors: Andrea
authors: A
authors: Vergallo
authors: Eleonora Del
authors: ED
authors: Prete
authors: Angelo
authors: A
authors: Nuti
authors: Ubaldo
authors: U
authors: Bonuccelli
authors: Sara
authors: S
authors: Gori
mesh_terms: D000328:Adult; D001007:Anxiety / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003863:Depression / Q000453:epidemiology; D005260:Female; D006801:Humans; D006930:Hyperalgesia / Q000453:epidemiology; D007407:Interviews as Topic; D016015:Logistic Models; D008297:Male; D008881:Migraine Disorders / Q000453:epidemiology*; D000857:Olfaction Disorders / Q000453:epidemiology*; D010147:Pain Measurement; D011795:Surveys and Questionnaires