title: Histone deacetylase 2 controls p53 and is a critical factor in tumorigenesis.
abstract: Histone deacetylase 2 (HDAC2) regulates biological processes by deacetylation of histones and non-histone proteins. HDAC2 is overexpressed in numerous cancer types, suggesting general cancer-relevant functions of HDAC2. In human tumors the TP53 gene encoding p53 is frequently mutated and wild-type p53 is often disarmed. Molecular pathways inactivating wild-type p53 often remain to be defined and understood. Remarkably, current data link HDAC2 to the regulation of the tumor suppressor p53 by deacetylation and to the maintenance of genomic stability. Here, we summarize recent findings on HDAC2 overexpression in solid and hematopoietic cancers with a focus on mechanisms connecting HDAC2 and p53 in vitro and in vivo. In addition, we present an evidence-based model that integrates molecular pathways and feedback loops by which p53 and further transcription factors govern the expression and the ubiquitin-dependent proteasomal degradation of HDAC2 and of p53 itself. Understanding the interactions between p53 and HDAC2 might aid in the development of new therapeutic approaches against cancer.
authors: Center for Molecular Biomedicine, Institute of Biochemistry and Biophysics, Department of Biochemistry, Friedrich Schiller University of Jena, Hans-Knöll-Str. 2, 07745 Jena, Germany. Electronic address: tobias.wagner@uni-jena.de.
authors: Tobias
authors: T
authors: Wagner
authors: Center for Molecular Biomedicine, Institute of Biochemistry and Biophysics, Department of Biochemistry, Friedrich Schiller University of Jena, Hans-Knöll-Str. 2, 07745 Jena, Germany.
authors: Peter
authors: P
authors: Brand
authors: Center for Molecular Biomedicine, Institute of Biochemistry and Biophysics, Department of Biochemistry, Friedrich Schiller University of Jena, Hans-Knöll-Str. 2, 07745 Jena, Germany.
authors: Thorsten
authors: T
authors: Heinzel
authors: Department of Toxicology, University Medical Center, Obere Zahlbacher Str. 67, 55131 Mainz, Germany. Electronic address: okraemer@uni-mainz.de.
authors: Oliver H
authors: OH
authors: Krämer
mesh_terms: D000107:Acetylation; D000818:Animals; D063646:Carcinogenesis; D056464:Histone Deacetylase 2 / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000201:enzymology*; D016159:Tumor Suppressor Protein p53 / Q000502:physiology*
chemical_list: D016159:Tumor Suppressor Protein p53; D056464:Histone Deacetylase 2
keywords: Cancer; HDAC inhibitors; HDAC2; RLIM; Sumoylation; p53