title: Transthyretin as a potential biomarker for the differential diagnosis between lung cancer and lung infection.
abstract: Satisfactory biomarkers for screening and early diagnosis of lung cancer remain scarce and require further investigation. The aim of the present study was to examine the changes of the biochemical and protein composition in the serum and pleural effusion from lung cancer and lung infection (bacterial pneumonia) patients. A total of 92 patients with lung cancer, 38 with bacterial pneumonia and 42 healthy controls were enrolled in the study. The serum levels of cholesterol, apolipoprotein A and transthyretin (TTR) in the lung cancer patients were higher than that of the lung infection patients (P<0.05). The levels of TTR were higher, whereas the activity of adenosine deaminase (ADA) was lower in the pleural effusion from the lung cancer patients compared to the lung infection patients (P<0.05). Furthermore, the pleural effusion/serum TTR ratios in the lung cancer patients were higher, whereas the ratios of ADA were lower (P<0.05). By matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis, four major peaks corresponding to native TTR, Sul-TTR, Cys-TTR and Cysgly-TTR were observed in the serum of the lung cancer and lung infection patients. A significant increase was found in the proportion of Cysgly-TTR in the pleural effusion from the patients with lung cancer. The data indicated that a combination of pleural effusion/serum TTR ratios and modified TTR may be beneficial for the differential diagnosis between lung cancer and lung infection.
authors: School of Laboratory Medicine, Tianjin Medical University, Tianjin 300203, P.R. China ; The Second Hospital of Tangshan, Tangshan, Hebei 063000, P.R. China.
authors: Hongmei
authors: H
authors: Ding
authors: The Second Hospital of Tangshan, Tangshan, Hebei 063000, P.R. China.
authors: Jianhua
authors: J
authors: Liu
authors: General Hospital of Tianjin Medical University, Tianjin 300052, P.R. China.
authors: Rong
authors: R
authors: Xue
authors: General Hospital of Tianjin Medical University, Tianjin 300052, P.R. China.
authors: Peng
authors: P
authors: Zhao
authors: School of Laboratory Medicine, Tianjin Medical University, Tianjin 300203, P.R. China.
authors: Yi
authors: Y
authors: Qin
authors: School of Laboratory Medicine, Tianjin Medical University, Tianjin 300203, P.R. China.
authors: Fang
authors: F
authors: Zheng
authors: School of Laboratory Medicine, Tianjin Medical University, Tianjin 300203, P.R. China.
authors: Xuguo
authors: X
authors: Sun
keywords: lung cancer; lung infection; matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; pleural effusion; transthyretin