title: Intromitochondrial IκB/NF-κB signaling pathway is involved in amyloid β peptide-induced mitochondrial dysfunction.
abstract: Mitochondrial dysfunction is a hallmark of amyloid β peptide (Aβ)-induced neuronal toxicity in Alzheimer's disease (AD). However, the underlying mechanism (s) of Aβ-induced mitochondrial dysfunction is still not fully understood. There is evidence that nuclear factor-κB (NF-κB) is involved in Aβ-induced neurotoxicity and is present in mitochondria. Using HT22 murine hippocampal neuronal cells and isolated mitochondria, the present study investigated whether intramitochondrial inhibitor of NF-κB (IκB)/NF-κB signaling pathway was involved in mitochondrial dysfunction induced by Aβ. It was found that Aβ impaired mitochondrial function through a NF-κB-dependent signaling pathway. Intramitochondrial IκBα/NF-κB pathway, induced by Aβ, decreased the expression of cytochrome c oxidase subunit (COXIII) and inhibited COX activity. These results provide new insights into the mechanism underlying the neurotoxic effect of Aβ and open up new therapeutic perspectives for AD.
authors: Department of Anatomy, Guangzhou Medical University, Guangzhou, Guangdong, 510182, China, shiyui431@126.com.
authors: Chun
authors: C
authors: Shi
authors: XiaoMing
authors: X
authors: Zhu
authors: Jisheng
authors: J
authors: Wang
authors: Dahong
authors: D
authors: Long
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism*; D016229:Amyloid beta-Peptides; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002460:Cell Line; D003576:Electron Transport Complex IV / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology; D020672:I-kappa B Proteins / Q000378:metabolism*; D051379:Mice; D008928:Mitochondria / Q000378:metabolism* / Q000473:pathology; D016328:NF-kappa B / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D010766:Phosphorylation; D015398:Signal Transduction
chemical_list: D016229:Amyloid beta-Peptides; D020672:I-kappa B Proteins; D016328:NF-kappa B; D003576:Electron Transport Complex IV