title: Human herpesvirus 8 viral interleukin-6 signaling through gp130 promotes virus replication in primary effusion lymphoma and endothelial cells.
abstract: The contributions of human herpesvirus 8 (HHV-8) viral interleukin-6 (vIL-6) to virus biology remain unclear. Here we examined the role of vIL-6/gp130 signaling in HHV-8 productive replication in primary effusion lymphoma and endothelial cells. Depletion and depletion-complementation experiments revealed that endoplasmic reticulum-localized vIL-6 activity via gp130 and gp130-activated signal transducer and activator of transcription (STAT) signaling, but not extracellular signal-regulated kinase (ERK) activation, was critical for vIL-6 proreplication activity. Our data significantly extend current understanding of vIL-6 function and associated mechanisms in HHV-8 biology.
authors: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors: Emily
authors: E
authors: Cousins
authors: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors: Yang
authors: Y
authors: Gao
authors: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors: Gordon
authors: G
authors: Sandford
authors: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA nichojo@jhmi.edu.
authors: John
authors: J
authors: Nicholas
mesh_terms: D001483:Base Sequence; D050822:Cytokine Receptor gp130 / Q000502:physiology*; D017931:DNA Primers; D042783:Endothelial Cells / Q000821:virology*; D019288:Herpesvirus 8, Human / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D054685:Lymphoma, Primary Effusion / Q000821:virology*; D015398:Signal Transduction; D014779:Virus Replication
chemical_list: D017931:DNA Primers; D015850:Interleukin-6; D050822:Cytokine Receptor gp130