title: [Evolutionary admonition: allergy].
abstract: The paper concerns phylogeny development of allergic reactivity, the most probable antecedents of allergic IgE antibodies, high affinity IgE receptor (Fc(epsilon)RI), presents comparative character of IgE - Fc(epsilon)RI and IgY- CHIR-AB1 interactions. The paper has given an insight of allergy as evolutionary selected reactivity for highly organized animals. This reactivity is directed to organization of allergen-specific inflammation and serves as biologically expedient, high-specific and high-sensitive reaction in response to allergen entering into the organism because of barrier tissue dysfunction. Such insight has raised a question on consequences of thoroughgoing allergy reactivity elimination for highly organized animals and their posterity.
authors: I S
authors: IS
authors: Gushchin
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics / Q000276:immunology*; D007136:Immunoglobulins / Q000235:genetics / Q000276:immunology
chemical_list: D007136:Immunoglobulins