title: Roles of Chinese medicine bioactive ingredients in the regulation of cellular function of endothelial progenitor cells.
abstract: To improve the function of endothelial progenitor cells (EPCs) is one of the goals in Chinese traditional therapy to treat various cardio-celebrovascular diseases. In the past decades, scholars in the field of traditional Chinese medicine (TCM) have found fifteen active compounds to regulate the function of EPC. These metabolites are extracted from thirteen, plant-based Chinese medicine, with majority of them as potent reductive or oxidative hydrophilic molecules containing phenyl groups. These active compounds either enhance the mobilization of EPC, or inhibit their apoptosis through different signaling pathways. In this review, the molecular structure, biophysical properties, and the plant sources of these active ingredients and their regulatory effects on the function of EPC are summarized, aiming to reveal the modern basis of Chinese medicine for promoting blood circulation and removing blood stasis at the progenitor cell level.
authors: School of Basic Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China. Electronic address: qitaozhao@163.com.
authors: Qi-Tao
authors: QT
authors: Zhao
authors: Affiliated Hospital of Shandong, University of Shandong Traditional Chinese Medicine, Jinan, 250014, China.
authors: Bao-Feng
authors: BF
authors: Li
authors: School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China.
authors: Hui
authors: H
authors: Kong
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D066026:Endothelial Progenitor Cells / Q000166:cytology* / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D004365:Drugs, Chinese Herbal
keywords: Apoptosis; Cardio-cerebrovascular protection; Chinese medicine bioactive ingredients; Endothelial progenitor cells; Mobilization; Oxidative stress