title: A polypyridyl-pyrene based off-on Cd²⁺ fluorescent sensor for aqueous phase analysis and living cell imaging.
abstract: By retaining the quadrapyridyl receptor of polypyridylhexaazatriphenylene (a Cd(2+) sensor reported by us) and extending its chromophoric group with pyrene, a chemical sensor (1) was designed and synthesized in this work. This sensor exhibit selective off-on fluorescence response to Cd(2+) over other metal ions, and the detection limit is as low as 0.02 μM. The Cd(2+) sensing of 1 has high water toleration and can be carried out in the media with the water content up to 70%. Additionally, 1 was successfully applied to the in vivo imaging of intracellular Cd(2+) in living HaLa cells, and showed low cytotoxicity and cell membrane permeability in these experiments. These results suggest that 1 has potential application in the Cd(2+) analysis of environmental and biological samples.
authors: Department of Chemistry, Nankai University, Tianjin 300071, PR China; Tianjin Key Laboratory on Metal and Molecule-Based Material Chemistry, Nankai University, Tianjin 300071, PR China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, PR China.
authors: Le-Le
authors: LL
authors: Yang
authors: Department of Chemistry, Nankai University, Tianjin 300071, PR China; Tianjin Key Laboratory on Metal and Molecule-Based Material Chemistry, Nankai University, Tianjin 300071, PR China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, PR China.
authors: Xiu-Ming
authors: XM
authors: Liu
authors: Department of Chemistry, Nankai University, Tianjin 300071, PR China; Tianjin Key Laboratory on Metal and Molecule-Based Material Chemistry, Nankai University, Tianjin 300071, PR China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, PR China.
authors: Kun
authors: K
authors: Liu
authors: Department of Chemistry, Nankai University, Tianjin 300071, PR China; Tianjin Key Laboratory on Metal and Molecule-Based Material Chemistry, Nankai University, Tianjin 300071, PR China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, PR China.
authors: Huan
authors: H
authors: Liu
authors: Department of Chemistry, Nankai University, Tianjin 300071, PR China; Tianjin Key Laboratory on Metal and Molecule-Based Material Chemistry, Nankai University, Tianjin 300071, PR China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, PR China.
authors: Fang-Yao
authors: FY
authors: Zhao
authors: Department of Chemistry, Nankai University, Tianjin 300071, PR China; Tianjin Key Laboratory on Metal and Molecule-Based Material Chemistry, Nankai University, Tianjin 300071, PR China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, PR China. Electronic address: wjruan@nankai.edu.cn.
authors: Wen-Juan
authors: WJ
authors: Ruan
authors: Department of Chemistry, Nankai University, Tianjin 300071, PR China; Tianjin Key Laboratory on Metal and Molecule-Based Material Chemistry, Nankai University, Tianjin 300071, PR China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, PR China. Electronic address: liyue84@nankai.edu.cn.
authors: Yue
authors: Y
authors: Li
authors: Department of Chemistry, Nankai University, Tianjin 300071, PR China; Tianjin Key Laboratory on Metal and Molecule-Based Material Chemistry, Nankai University, Tianjin 300071, PR China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, PR China. Electronic address: changze@nankai.edu.cn.
authors: Ze
authors: Z
authors: Chang
authors: Department of Chemistry, Nankai University, Tianjin 300071, PR China; Tianjin Key Laboratory on Metal and Molecule-Based Material Chemistry, Nankai University, Tianjin 300071, PR China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, PR China.
authors: Xian-He
authors: XH
authors: Bu
mesh_terms: D002104:Cadmium / Q000032:analysis* / Q000737:chemistry; D004784:Environmental Monitoring / Q000379:methods; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D018613:Microscopy, Confocal / Q000379:methods*; D008856:Microscopy, Fluorescence / Q000379:methods*; D008956:Models, Chemical; D015394:Molecular Structure; D011721:Pyrenes / Q000138:chemical synthesis / Q000737:chemistry*; D015203:Reproducibility of Results; D012996:Solutions / Q000737:chemistry; D013050:Spectrometry, Fluorescence / Q000379:methods*; D014867:Water / Q000737:chemistry
chemical_list: D005456:Fluorescent Dyes; D011721:Pyrenes; D012996:Solutions; D002104:Cadmium; D014867:Water; C030984:pyrene
keywords: Cd2+ ion; Cell imaging; Fluorescent sensor; Quadrapyridyl type receptor; Water toleration