title: [Correlation of platelet parameters with delayed graft function after kidney transplantation].
abstract: OBJECTIVE
  To investigate the relationship between platelet parameters and delayed graft function (DGF) early after kidney transplantation.
  
  
  METHODS
  We retrospectively analyzed the clinical data of 232 recipients within 2 months following kidney transplantation performed between January, 2009 and September, 2013, among whom 29 experienced DGF. The laboratory data of the preoperative and postoperative platelets were collected from all the recipients.
  
  
  RESULTS
  Compared with the preoperative levels, the platelet number (PLT) and platelet hematocrit (PCT) were decreased on day 1 after kidney transplantation and was the lowest on day 5 (P<0.05), followed by gradual increase till reaching the highest levels on day 15 (P<0.05) and recovery of the preoperative level in days 30-60. The average platelet volume (MPV), platelet volume distribution width (PDW) and large platelet ratio (P-LCR) were increased on day 1, highest on day 7 (P<0.05), and reduced to the preoperative level on day 15, but then rose again slowly. MPV and P-LCR in days 30 to 60 and PDW in days 45 to 60 were significantly higher than the preoperative levels (P<0.05). The patients with DGF showed lowered PLT than those without DGF since day 2, and this difference was statistically significant in days 7 to 10, while PCT remained comparable between the two groups; MPV, PDW, and P-LCR were higher in DGF group than in DGF-free group with statistically significant difference on days 7, 10, and 15 (P<0.05).
  
  
  CONCLUSIONS
  Platelet function is associated with postoperative renal graft function recovery, and platelet parameters can provide new markers for monitoring the occurrence and reversion of DGF.
authors: Department of Organ Transplantation, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. E-mail: fusaoj@medmail.com.cn.
authors: Shaojie
authors: S
authors: Fu
authors: Binbin
authors: B
authors: Guo
authors: Lixin
authors: L
authors: Yu
authors: Yibin
authors: Y
authors: Wang
authors: Chuanfu
authors: C
authors: DU
authors: Lulu
authors: L
authors: Xiao
authors: Minjie
authors: M
authors: Zhou
authors: Min
authors: M
authors: Luo
mesh_terms: D015415:Biomarkers; D001792:Blood Platelets / Q000502:physiology*; D051799:Delayed Graft Function; D006801:Humans; D016030:Kidney Transplantation; D015539:Platelet Activation; D010976:Platelet Count; D011184:Postoperative Period; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers