title: Prevention effect of medical self-crosslinking sodium hyaluronate gel on epidural scar adhesion after laminectomy.
abstract: OBJECTIVE
  To analyze the effect and medical self-crosslinking sodium hyaluronate gel on epidural scar adhesion after laminectomy.
  
  
  METHODS
  A total of 24 New Zealand L5 laminectomy rabbits were randomly divided into four groups, group A as the control group without any treatment; group B covered by sodium hyaluronate gel; group C and group D covered by 0.5 and 1.0 mL medical self-crosslinking sodium hyaluronate gel. All rabbits were scored at various time points after 2, 4, 6, 8, 12 weeks, then the formation of scar was observed.
  
  
  RESULTS
  In Groups B, C, D loose scar tissue occurred after 2 weeks of the operation, scar tissues were significantly less than that in group A, with mild inflammatory reaction. After 8 weeks, the scar tissues of group B were significantly more than that of groups C, D. After two weeks, group B, C were back to the preoperative level; After 4 weeks, group D was back to the preoperative level; After four weeks, the CSEP of group A was increased significantly, which was significantly higher than that in groups B, C, D. The motor function score of group A, group B and group C were the same as preoperative, but that in group D it was decreased significantly, and then it gradually recovered. After 4 weeks it kept a stable level. The motor function score of group A was decreased gradually after the operation, which kept a stable level after 4 weeks, the motor function score was significantly lower than that in groups B, C, D.
  
  
  CONCLUSIONS
  Determination of somatosensory evoked potentials is sensitive indicator of spinal cord injury; Application of medical self-crosslinking sodium hyaluronate gel is effective on epidural scar adhesion after laminectomy.
authors: Orthopaedic Department of PLA 474 Hospital, Xinjiang 830011, China. Electronic address: hworejwkdf@163.com.
authors: Hua
authors: H
authors: Liu
authors: Orthopaedic Department of PLA 474 Hospital, Xinjiang 830011, China.
authors: Hai-Feng
authors: HF
authors: Li
authors: Spinal Surgery Department of of First Affiliated Hospital of Xinjiang University, Xinjiang 830011, China.
authors: Jian-Yuan
authors: JY
authors: Wang
mesh_terms: D000818:Animals; D002921:Cicatrix / Q000188:drug therapy* / Q000517:prevention & control; D004824:Epidural Space / Q000601:surgery*; D006820:Hyaluronic Acid / Q000494:pharmacology / Q000627:therapeutic use; D007796:Laminectomy / Q000009:adverse effects*; D009043:Motor Activity / Q000187:drug effects; D011183:Postoperative Complications / Q000188:drug therapy* / Q000517:prevention & control; D011817:Rabbits; D000267:Tissue Adhesions / Q000188:drug therapy* / Q000517:prevention & control
chemical_list: D006820:Hyaluronic Acid
keywords: Animal; Hyaluronic acid; Induced potentials; Laminectomy; Somatosensory