title: Association of the c.385C>A (p.Pro129Thr) polymorphism of the fatty acid amide hydrolase gene with anorexia nervosa in the Japanese population.
abstract: The functional c.385C>A single-nucleotide polymorphism (SNP) in the fatty acid amide hydrolase (FAAH) gene, one of the major degrading enzymes of endocannabinoids, is reportedly associated with anorexia nervosa (AN). We genotyped the c.385C>A SNP (rs324420) in 762 lifetime AN and 605 control participants in Japan. There were significant differences in the genotype and allele frequencies of c.385C>A between the AN and control groups. The minor 385A allele was less frequent in the AN participants than in the controls (allele-wise, odds ratio = 0.799, 95% confidence interval [CI] 0.653-0.976, P = 0.028). When the cases were subdivided into lifetime restricting subtype AN and AN with a history of binge eating or purging, only the restricting AN group exhibited a significant association (allele-wise, odds ratio = 0.717, 95% CI 0.557-0.922, P = 0.0094). Our results suggest that having the minor 385A allele of the FAAH gene may be protective against AN, especially restricting AN. This finding supports the possible role of the endocannabinoid system in susceptibility to AN.
authors: Department of Psychosomatic Research, National Institute of Mental Health, National Center of Neurology and Psychiatry Kodaira, Tokyo, Japan.
authors: Tetsuya
authors: T
authors: Ando
authors: Department of Psychosomatic Medicine, Kohnodai Hospital, National Center for Global Health and Medicine Ichikawa, Chiba, Japan.
authors: Naho
authors: N
authors: Tamura
authors: Division of Psychosomatic Medicine, Department of Neurology, University of Occupational and Environmental Health Kitakyushu, Fukuoka, Japan ; Department of Psychosomatic Medicine, Yahata Kosei Hospital Kitakyushu, Fukuoka, Japan.
authors: Takashi
authors: T
authors: Mera
authors: Department of Psychosomatic Medicine, Graduate School of Medical Sciences, Kyushu University Fukuoka, Fukuoka, Japan.
authors: Chihiro
authors: C
authors: Morita
authors: Takei Medical Clinic Kagoshima, Kagoshima, Japan.
authors: Michiko
authors: M
authors: Takei
authors: Department of Psychosomatic Medicine, Saitama Social Insurance Hospital Saitama, Saitama, Japan.
authors: Chiemi
authors: C
authors: Nakamoto
authors: Department of Psychosomatic Medicine, Kamibayashi Memorial Hospital Ichinomiya, Aichi, Japan.
authors: Masanori
authors: M
authors: Koide
authors: Health Services Center, National Graduate Institute for Policy Studies Minato-ku, Tokyo, Japan.
authors: Mari
authors: M
authors: Hotta
authors: Department of Psychosomatic Medicine, Nogami Hospital Kagoshima, Kagoshima, Japan.
authors: Tetsuro
authors: T
authors: Naruo
authors: Department of Psychosomatic Medicine, Graduate School of Medical Sciences, Kyushu University Fukuoka, Fukuoka, Japan.
authors: Keisuke
authors: K
authors: Kawai
authors: Department of Psychosomatic Medicine, Family Hospital Satsuma Satsumasendai, Kagoshima, Japan.
authors: Toshihiro
authors: T
authors: Nakahara
authors: Division of General Medicine, Aichi Medical University Hospital Nagakute, Aichi, Japan ; Setoguchi Psychosomatic Clinic Seto, Aichi, Japan.
authors: Chikara
authors: C
authors: Yamaguchi
authors: Department of Neuropsychiatry, Osaka City University Graduate School of Medicine Osaka, Osaka, Japan ; Mental Health Clinic of Dr. Nagata at Nanba Osaka, Osaka, Japan.
authors: Toshihiko
authors: T
authors: Nagata
authors: Department of Internal Medicine, Yufuin Koseinenkin Hospital Yufuin, Oita, Japan.
authors: Kazuyoshi
authors: K
authors: Ookuma
authors: Health Service Center, Hiroshima University Higashihiroshima, Hiroshima, Japan.
authors: Yuri
authors: Y
authors: Okamoto
authors: Graduate School of Welfare Society, The International University of Kagoshima Kagoshima, Kagoshima, Japan ; Nishihara Hoyouin Kaya, Kagoshima, Japan.
authors: Takao
authors: T
authors: Yamanaka
authors: Department of Neuropsychiatry, Osaka City University Graduate School of Medicine Osaka, Osaka, Japan ; Hamadera Hospital Takaishi, Osaka, Japan.
authors: Nobuo
authors: N
authors: Kiriike
authors: Department of Nutrition, School of Home Economics and Science, Tokyo Kasei University Itabashi-ku, Tokyo, Japan.
authors: Yuhei
authors: Y
authors: Ichimaru
authors: Department of Psychosomatic Medicine, Kohnodai Hospital, National Center for Global Health and Medicine Ichikawa, Chiba, Japan.
authors: Toshio
authors: T
authors: Ishikawa
authors: Department of Psychosomatic Research, National Institute of Mental Health, National Center of Neurology and Psychiatry Kodaira, Tokyo, Japan ; School of Health Sciences at Fukuoka, International University of Health and Welfare Ohkawa, Japan.
authors: Gen
authors: G
authors: Komaki
keywords: Anandamide; cannabinoid 1 receptor; eating disorder; endocannabinoid