title: Cross-talk between endothelin-1 and mineral metabolism in hemodialysis patients: a cross-sectional study.
abstract: BACKGROUND
  Endotheline-1 (ET-1), an endothelial mediator, influences on mineral metabolism; especially vascular calcification in uremic patients.
  
  
  OBJECTIVE
  The aim of the present study was to evaluate of ET-1, high-sensitivity C-reactive protein (hs-CRP) and mineral metabolites as the main factors for vascular calcification and inflammation in hemodialysis (HD) patients.
  
  
  METHODS
  In this cross-sectional study, 46 chronic stable HD patients were selected from nephrology departments of Tabriz University of Medical Sciences affiliated hospitals and classified based on phosphorus (P), Ca-P product (Ca × P) and intact Parathyroid Hormone (iPTH) levels. We evaluated fasting serum ET-1and hs-CRP levels by the standard methods and compared with 46 healthy control subjects.
  
  
  RESULTS
  The levels of serum hs-CRP and ET-1 were significantly higher in the patient's group compared with controls (4.40 ± 1.26 vs. 1.38 ± 1.61, P < 0.0001, and 2.31 ± 0.87 vs. 0.75 ± 0.48, P < 0.0001, respectively) and with regard to Ca × P product cut-off point (3.99 ± 0.78 vs. 5.33 ± 1.64, P < 0.0001, and 2 ± 0.73 vs. 3.04 ± 0.73, P < 0.0001 respectively). ET-1 was correlated significantly with hs-CRP level (r = 0.776, P < 0.0001). Serum P, Ca × P and iPTH levels directly and Ca indirectly were correlated with serum ET-1 in HD patients (r = 0.932, P < 0.0001, r = 0.766, P < 0.0001, r = 0.514, P < 0.0001, r = -0.538, P < 0.0001 respectively). Multiple regression analysis demonstrated that serum P were independently associated with ET-1 levels (β = 0.932, P < 0.0001).
  
  
  CONCLUSIONS
  Serum P and iPTH levels were independently associated with ET-1 and those may play a role in development of endothelial dysfunction in chronic kidney disease.
authors: Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, IR Iran.
authors: Jamal
authors: J
authors: Halaj Zadeh
authors: Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
authors: Amir
authors: A
authors: Ghorbanihaghjo
authors: Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, IR Iran.
authors: Nadereh
authors: N
authors: Rashtchizadeh
authors: Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
authors: Hassan
authors: H
authors: Argani
authors: Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, IR Iran.
authors: Shahnam
authors: S
authors: Valizadeh
authors: Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, IR Iran.
authors: Najat
authors: N
authors: Halaj
authors: Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, IR Iran.
authors: Amir Mansour
authors: AM
authors: Vatankhah
keywords: Endothelin-1; Hemodialysis; Parathyroid Hormone