title: Osteoprotegerin is not a determinant of metabolic syndrome in sub-Saharan Africans after age adjustment.
abstract: OBJECTIVE
  Osteoprotegerin (OPG), a soluble member of tumor necrosis factor receptor superfamily that inhibits bone resorption, has been suggested as a cardiovascular risk factor in humans. In this study, we aim to investigate the potential relationship between OPG and MetS (MetS) in a sub-Saharan African population.
  
  
  METHODS
  Four hundred and eleven volunteers (152 men, 259 women) aged ≥18 years recruited from the general population in Douala and Edea, Cameroon participated in this study. Anthropometric parameters measured and blood samples were collected for glucose, serum lipids and OPG concentrations measurements. Mean differences of the variables in different groups were compared using Students' t test. We performed logistic regressions to analyze the impact of independent factors on the relation between OPG and MetS outcome. MetS was defined using the Joint Interim Statement 2009.
  
  
  RESULTS
  OPG levels did not vary significantly between both men and women with and without MetS (both P>0.05). However, with high fasting blood glucose (≥5.6 mmol/L) had a significantly higher OPG level than those with lower glucose level (P=0.014). In multiple logistic regression analysis, MetS did not show any significant association with serum OPG levels in men and women after adjusting for age, physical activity, alcohol consumption and menopausal status in women (P=0.720 and P=0.930 respectively).
  
  
  CONCLUSIONS
  This study failed to demonstrate any relationship between OPG and MetS. Nevertheless, the positive association between blood glucose and OPG levels reveals that OPG might be involved in cardiovascular risk development in this sub-Saharan African population.
authors: Department of animal science, faculty of science, university of Douala, Douala, Cameroon.
authors: Clarisse Noël
authors: CN
authors: Ayina Ayina
authors: Department of hormonal biology, Saint-Louis hospital, university Paris-Diderot Paris-7, PO Box 75010, Public assistance-Paris Hospitals, 75013 Paris, France; UMR-S Inserm 872, Cordeliers research center, Pierre et Marie-Curie university Paris-6, Paris, France.
authors: Philippe
authors: P
authors: Boudou
authors: Department of hormonal biology, Saint-Louis hospital, university Paris-Diderot Paris-7, PO Box 75010, Public assistance-Paris Hospitals, 75013 Paris, France.
authors: Ibrahim
authors: I
authors: Fidaa
authors: Diabetes research center, Brussels Free university-VUB, Brussels, Belgium.
authors: Eric Vounsia
authors: EV
authors: Balti
authors: Institute of health and society, university of Newcastle upon Tyne, UK; Department of internal medicine, national obesity center, faculty of medicine and biomedical sciences, university of Yaounde I, P.O. Box 7535, Yaounde, Cameroon. Electronic address: sobngwieugene@yahoo.fr.
authors: Eugene
authors: E
authors: Sobngwi
authors: Department of animal science, higher teacher's training college, university of Yaounde I, Yaounde, Cameroon.
authors: Laurent Serge
authors: LS
authors: Etoundi Ngoa
authors: University center of diabetes and complications in Lariboisière hospital, university Paris-Diderot Paris-7, Public assistance-Paris Hospitals, Paris, France; UMR-S Inserm 872, Cordeliers research center, Pierre et Marie-Curie university Paris-6, Paris, France.
authors: Jean François
authors: JF
authors: Gautier
mesh_terms: D000328:Adult; D017954:Africa South of the Sahara; D000368:Aged; D000375:Aging; D000428:Alcohol Drinking; D001786:Blood Glucose / Q000032:analysis*; D002318:Cardiovascular Diseases; D015444:Exercise; D005215:Fasting; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008593:Menopause; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D053244:Osteoprotegerin / Q000097:blood*; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D001786:Blood Glucose; D053244:Osteoprotegerin; C506030:TNFRSF11B protein, human
keywords: Afrique sub-saharienne; Cameroon; Cameroun; Metabolic syndrome; Osteoprotegerin; Ostéoprotégérine; Sub-Saharan Africa; Syndrome métabolique