title: [Endometriosis: increasing concentrations of serum interleukin-1β and interleukin-1sRII is associated with the deep form of this pathology].
abstract: OBJECTIVE
  To assess interleukin-1β (IL-1β) and its inhibitory soluble interleukin-1 receptor type II (IL-1sRII) levels into the serum of patients with various forms of endometriosis and normal women, and investigate the correlation with disease activity.
  
  
  METHODS
  In this prospective laboratory study (2005-2010), 510 women with histologically proven endometriosis and 93 endometriosis-free controls have been enrolled. Laparoscopic complete exploration of the abdominopelvic cavity and blood samples have been performed in each patient. For each serum, IL-1β and IL-1sRII have been evaluated using Elisa.
  
  
  RESULTS
  IL-1β and IL-1sRII have been respectively detectable in 64% and 54.6% of serum samples from all 603 women studied. IL-1β was higher in women with deep infiltrating endometriosis (DIE) (mean 10.0pg/mL [0.005-416.2]) than in endometriosis-free women (mean 0.5pg/mL [0.01-1.7], P<0.01) or in women with superficial endometriosis (SUP) (mean 0.6pg/mL [0.1-2.9], P<0.01). Also, IL-1sRII was higher in DIE (mean 236.7pg/mL [0.9-6975]) than in the witness group (mean 85.0pg/mL [1-235.2], P<0.05) or in SUP (mean 85.1pg/mL [0.6-302], P<0.01).
  
  
  CONCLUSIONS
  This study highlights both a marked significant increase in serum IL-1β and IL-1sRII levels in DIE compared to SUP and normal women and suggests that a defect in the control of IL-1 can impact the pathophysiology of endometriosis.
authors: Département de gynécologie obstétrique et médecine de la reproduction, faculté de médecine, université Paris Descartes, Sorbonne Paris Cité, hôpital Cochin, AP-HP, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France. Electronic address: lambertsixtine@gmail.com.
authors: S
authors: S
authors: Lambert
authors: Département de gynécologie obstétrique et médecine de la reproduction, faculté de médecine, université Paris Descartes, Sorbonne Paris Cité, hôpital Cochin, AP-HP, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France; Laboratoire d'immunologie, EA 1833, faculté de médecine, université Paris Descartes, Sorbonne Paris Cité, hôpital Cochin, AP-HP, 75679 Paris, France; Inserm, unité de recherche U1016, faculté de médecine, institut Cochin, CNRS (UMR8104), université Paris Descartes, Sorbonne Paris Cité, 75014 Paris, France.
authors: P
authors: P
authors: Santulli
authors: Laboratoire d'immunologie, EA 1833, faculté de médecine, université Paris Descartes, Sorbonne Paris Cité, hôpital Cochin, AP-HP, 75679 Paris, France.
authors: S
authors: S
authors: Chouzenoux
authors: Département de gynécologie obstétrique et médecine de la reproduction, faculté de médecine, université Paris Descartes, Sorbonne Paris Cité, hôpital Cochin, AP-HP, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France; Inserm, unité de recherche U1016, faculté de médecine, institut Cochin, CNRS (UMR8104), université Paris Descartes, Sorbonne Paris Cité, 75014 Paris, France.
authors: L
authors: L
authors: Marcellin
authors: Département de gynécologie obstétrique et médecine de la reproduction, faculté de médecine, université Paris Descartes, Sorbonne Paris Cité, hôpital Cochin, AP-HP, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France; Inserm, unité de recherche U1016, faculté de médecine, institut Cochin, CNRS (UMR8104), université Paris Descartes, Sorbonne Paris Cité, 75014 Paris, France.
authors: B
authors: B
authors: Borghese
authors: Département de gynécologie obstétrique et médecine de la reproduction, faculté de médecine, université Paris Descartes, Sorbonne Paris Cité, hôpital Cochin, AP-HP, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France.
authors: D
authors: D
authors: de Ziegler
authors: Laboratoire d'immunologie, EA 1833, faculté de médecine, université Paris Descartes, Sorbonne Paris Cité, hôpital Cochin, AP-HP, 75679 Paris, France.
authors: F
authors: F
authors: Batteux
authors: Département de gynécologie obstétrique et médecine de la reproduction, faculté de médecine, université Paris Descartes, Sorbonne Paris Cité, hôpital Cochin, AP-HP, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France; Laboratoire d'immunologie, EA 1833, faculté de médecine, université Paris Descartes, Sorbonne Paris Cité, hôpital Cochin, AP-HP, 75679 Paris, France; Inserm, unité de recherche U1016, faculté de médecine, institut Cochin, CNRS (UMR8104), université Paris Descartes, Sorbonne Paris Cité, 75014 Paris, France.
authors: C
authors: C
authors: Chapron
mesh_terms: D000328:Adult; D004715:Endometriosis / Q000097:blood* / Q000473:pathology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D053583:Interleukin-1beta / Q000097:blood*; D011446:Prospective Studies; D053574:Receptors, Interleukin-1 Type II / Q000097:blood*
chemical_list: D053583:Interleukin-1beta; D053574:Receptors, Interleukin-1 Type II
keywords: Cytokines; Endometriosis; Endométriose; IL-1sRII; IL-1β; Pathogenesis; Pathogenèse; Serum; Sérum