title: Triglyceride is strongly associated with nonalcoholic fatty liver disease among markers of hyperlipidemia and diabetes.
abstract: The aim of the present study was to reveal the metabolic disorders most commonly associated with nonalcoholic fatty liver disease (NAFLD). Triglyceride (TG), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), blood glucose (BG) and hemoglobin A1c (HbA1c) were analyzed. NAFLD was diagnosed using abdominal ultrasound (US), and TG, HDL, LDL, BG and HbA1c were immediately collected on the same day and subjected to multivariate regression analysis. Stepwise analysis was performed to select the variables that were closely associated with NAFLD. The patients who were positive for the hepatitis B antigen and hepatitis C antibody were excluded from the study. Additionally, the patients who were prescribed prednisolone or methotrexate were excluded from the study as these agents may cause NAFLD or liver toxicity. The study included 168 and 125 patients with and without NAFLD, respectively. TG, BG and HbA1c were strongly correlated with NAFLD. Among these parameters, TG was the strongest predictor of NAFLD (χ2=9.89, P=0.0017). TG was the parameter that was most strongly associated with NAFLD. In conclusion, elevated TG was a marker of NAFLD.
authors: Department of Gastroenterology, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284-0003, Japan.
authors: Minoru
authors: M
authors: Tomizawa
authors: Sato Clinic, Chiba City, Chiba 264-0021, Japan.
authors: Yuji
authors: Y
authors: Kawanabe
authors: Department of Radiology, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284-0003, Japan.
authors: Fuminobu
authors: F
authors: Shinozaki
authors: Sato Clinic, Chiba City, Chiba 264-0021, Japan.
authors: Sumihiko
authors: S
authors: Sato
authors: Department of Neurology, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284-0003, Japan.
authors: Yasufumi
authors: Y
authors: Motoyoshi
authors: Department of Rheumatology, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284-0003, Japan.
authors: Takao
authors: T
authors: Sugiyama
authors: Department of Pediatrics, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284-0003, Japan.
authors: Shigenori
authors: S
authors: Yamamoto
authors: Department of Rheumatology, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284-0003, Japan.
authors: Makoto
authors: M
authors: Sueishi
keywords: blood glucose; hemoglobin A1c; multivariate regression analysis; receiver operating characteristics