title: Organocatalytic cascade reactions: towards the diversification of hydroisochromenes and chromenes through two different activation modes.
abstract: The organocatalytic enantioselective syntheses of functionalized hydroisochromenes and chromenes by trienamine-mediated [4+2]-cycloaddition/nucleophilic ring-closing and iminium-ion/aminal-mediated oxa-Michael/Michael/nucleophilic ring-closing with 2-nitroallylic alcohols are presented. The corresponding cycloadducts, with up to five stereocenters, are formed in good yield and excellent enantioselectivities. The synthetic applications of the obtained products have been demonstrated.
authors: Center for Catalysis, Department of Chemistry, Aarhus University, 8000 Aarhus C (Denmark).
authors: David
authors: D
authors: Cruz Cruz
authors: Rasmus
authors: R
authors: Mose
authors: Clarisa
authors: C
authors: Villegas Gómez
authors: Stine V
authors: SV
authors: Torbensen
authors: Martin S
authors: MS
authors: Larsen
authors: Karl Anker
authors: KA
authors: Jørgensen
keywords: aminocatalysis; asymmetric catalysis; cascade reactions; chromenes hydroisochromenes