title: The use of spirocyclic scaffolds in drug discovery.
abstract: Owing to their inherent three-dimensionality and structural novelty, spiro scaffolds have been increasingly utilized in drug discovery. In this brief review, we highlight selected examples from the primary medicinal chemistry literature during the last three years to demonstrate the versatility of spiro scaffolds. With recent progress in synthetic methods providing access to spiro building blocks, spiro scaffolds are likely to be used more frequently in drug discovery.
authors: Vitae Pharmaceuticals Inc., 502 West Office Center Drive, Fort Washington, PA 19034, United States. Electronic address: yzheng@vitaerx.com.
authors: Yajun
authors: Y
authors: Zheng
authors: Vitae Pharmaceuticals Inc., 502 West Office Center Drive, Fort Washington, PA 19034, United States.
authors: Colin M
authors: CM
authors: Tice
authors: Vitae Pharmaceuticals Inc., 502 West Office Center Drive, Fort Washington, PA 19034, United States.
authors: Suresh B
authors: SB
authors: Singh
mesh_terms: D000818:Animals; D002626:Chemistry, Pharmaceutical; D055808:Drug Discovery; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D006571:Heterocyclic Compounds; D013141:Spiro Compounds
keywords: Drug discovery; Scaffold; Spirocyclic