title: Cerebellum involvement in cortical sensorimotor circuits for the control of voluntary movements.
abstract: Sensorimotor integration is crucial to perception and motor control. How and where this process takes place in the brain is still largely unknown. Here we analyze the cerebellar contribution to sensorimotor integration in the whisker system of mice. We identify an area in the cerebellum where cortical sensory and motor inputs converge at the cellular level. Optogenetic stimulation of this area affects thalamic and motor cortex activity, alters parameters of ongoing movements and thereby modifies qualitatively and quantitatively touch events against surrounding objects. These results shed light on the cerebellum as an active component of sensorimotor circuits and show the importance of sensorimotor cortico-cerebellar loops in the fine control of voluntary movements.
authors: 1] Institut de Biologie de l'Ecole Normale Supérieure, Paris, France. [2] Centre National de la Recherche Scientifique (CNRS) UMR8197, Paris, France. [3] Institut National de la Santé et de la Recherche Médicale (INSERM) U1024, Paris, France. [4].
authors: Rémi D
authors: 0000000258291344
authors: RD
authors: Proville
authors: 1] Institut de Biologie de l'Ecole Normale Supérieure, Paris, France. [2] Centre National de la Recherche Scientifique (CNRS) UMR8197, Paris, France. [3] Institut National de la Santé et de la Recherche Médicale (INSERM) U1024, Paris, France. [4].
authors: Maria
authors: M
authors: Spolidoro
authors: 1] Institut de Biologie de l'Ecole Normale Supérieure, Paris, France. [2] Centre National de la Recherche Scientifique (CNRS) UMR8197, Paris, France. [3] Institut National de la Santé et de la Recherche Médicale (INSERM) U1024, Paris, France.
authors: Nicolas
authors: 0000000312878606
authors: N
authors: Guyon
authors: 1] Institut de Biologie de l'Ecole Normale Supérieure, Paris, France. [2] Centre National de la Recherche Scientifique (CNRS) UMR8197, Paris, France. [3] Institut National de la Santé et de la Recherche Médicale (INSERM) U1024, Paris, France.
authors: Guillaume P
authors: GP
authors: Dugué
authors: 1] Center for Interdisciplinary Research in Biology, Collège de France, Paris, France. [2] CNRS UMR7241, Paris, France. [3] INSERM U1050, Paris, France.
authors: Fekrije
authors: F
authors: Selimi
authors: Institut des Neurosciences Cellulaires et Intégratives, CNRS UPR 3212, Université de Strasbourg, Strasbourg, France.
authors: Philippe
authors: P
authors: Isope
authors: 1] Institut de Biologie de l'Ecole Normale Supérieure, Paris, France. [2] Centre National de la Recherche Scientifique (CNRS) UMR8197, Paris, France. [3] Institut National de la Santé et de la Recherche Médicale (INSERM) U1024, Paris, France. [4].
authors: Daniela
authors: D
authors: Popa
authors: 1] Institut de Biologie de l'Ecole Normale Supérieure, Paris, France. [2] Centre National de la Recherche Scientifique (CNRS) UMR8197, Paris, France. [3] Institut National de la Santé et de la Recherche Médicale (INSERM) U1024, Paris, France. [4].
authors: Clément
authors: C
authors: Léna
mesh_terms: D000344:Afferent Pathways / Q000166:cytology / Q000502:physiology; D000818:Animals; D002531:Cerebellum / Q000166:cytology / Q000502:physiology*; D004525:Efferent Pathways / Q000166:cytology / Q000502:physiology; D004558:Electric Stimulation; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009068:Movement / Q000502:physiology*; D062308:Optogenetics; D011149:Pons / Q000166:cytology / Q000502:physiology; D011689:Purkinje Cells / Q000502:physiology; D066191:Sensorimotor Cortex / Q000166:cytology / Q000502:physiology*; D013028:Space Perception / Q000502:physiology; D013788:Thalamus / Q000166:cytology / Q000502:physiology; D055698:Touch Perception / Q000502:physiology*; D014738:Vibrissae / Q000502:physiology; D014836:Volition / Q000502:physiology*