title: Relationship of MDA plasma concentrations to long-term survival of breast cancer patients.
abstract: OBJECTIVE
  Malondialdehyde (MDA) is a product of polyunsaturated fatty acid oxidation. Changes in MDA concentrations have been found in patients with various types of cancer. The aim of this study was to analyze the relationship of MDA plasma concentrations to the long-term survival of patients with breast cancer.
  
  
  METHODS
  We conducted a retrospective study which included 106 patients at various disease stages (I - n = 2; II - n = 30; III - n = 51; IV - n = 23). Plasma MDA concentrations were measured at the time of diagnosis. Study participants were divided into groups according to age (<55 years vs ≥55 years), disease stage, and MDA concentration (<9 mmol/L vs ≥9 mmol/L). Survival rates between groups were compared using the Kaplan-Meier method.
  
  
  RESULTS
  We found that higher MDA concentrations were associated with lower survival rates in stage I and II breast cancer. No significant association was found in patients with stage III and IV disease. Multivariate analysis showed that the MDA level was the only independent prognostic factor for patient survival in the total study group (hazard ratio 1.57, P = 0.03).
  
  
  CONCLUSIONS
  MDA can be used as a prognostic factor in early stages of breast cancer.
authors: Janina
authors: J
authors: Didziapetriene
authors: Giedre
authors: G
authors: Smailyte
authors: Jaroslav
authors: J
authors: Bublevic
authors: Birute
authors: B
authors: Kazbariene
authors: Vytautas
authors: V
authors: Kasiulevicius
authors: Rimantas
authors: R
authors: Stukas
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D001943:Breast Neoplasms / Q000097:blood* / Q000401:mortality* / Q000473:pathology; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor; D008315:Malondialdehyde