title: Comparison of the safety and efficacy of biodegradable polymer biolimus-eluting stents and durable polymer everolimus-eluting stents: propensity score-matched analysis.
abstract: OBJECTIVE
  We investigated and compared the clinical outcomes between biodegradable polymer biolimus-eluting stents (BES) and durable polymer everolimus-eluting stents (EES) in a single-center prospective registry.
  
  
  BACKGROUND
  There is limited data regarding the safety and efficacy of the biodegradable BES compared to second-generation drug-eluting stents.
  
  
  METHODS
  From January 2010 to April 2012, a total of 1,279 patients were treated with BES (n = 647) or EES (n = 632) in a single center. We included 1,231 patients (BES = 625, EES = 606) after excluding 48 patients (BES = 22, EES = 26) with acute myocardial infarction accompanied by cardiogenic shock. The 1-year incidences of target lesion failure (TLF), patient-oriented composite outcomes (POCO), and stent thrombosis (ST) after the index procedure were compared in propensity score-matched analyses.
  
  
  RESULTS
  Propensity score matching yielded 406 well-balanced pairs (EES = 406, BES-B = 406). In the propensity-matched population, the 1-year incidence of TLF (BES = 3.0% vs. EES = 2.5%, P = 0.666) and POCO (BES = 5.4% vs. EES = 6.4%, P = 0.552) were similar between the 2 groups. In addition, the incidence of definite or probable ST was also similar (BES = 0.74% vs. EES = 0.74%, P = 1.000). In subgroup analysis, the number of patients who reached the primary end-point did not differ significantly between the 2 groups.
  
  
  CONCLUSIONS
  In a single-center registry with unrestricted use of EES and BES-B, these stents showed comparable efficacy and safety in terms of TLF, POCO, and ST at 1-year follow-up.
authors: Department of Cardiology, Wonju College of Medicine, Yonsei University, Wonju, Republic of Korea.
authors: Ji Hyun
authors: JH
authors: Lee
authors: Jun-Won
authors: JW
authors: Lee
authors: Young Jin
authors: YJ
authors: Youn
authors: Min Soo
authors: MS
authors: Ahn
authors: Sung Gyun
authors: SG
authors: Ahn
authors: Jang Young
authors: JY
authors: Kim
authors: Byung-Su
authors: BS
authors: Yoo
authors: Seung-Hwan
authors: SH
authors: Lee
authors: Eunhee
authors: E
authors: Choi
authors: Junghan
authors: J
authors: Yoon
mesh_terms: D020341:Absorbable Implants; D000368:Aged; D054855:Drug-Eluting Stents; D000068338:Everolimus / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D063868:Patient Outcome Assessment; D062645:Percutaneous Coronary Intervention; D057216:Propensity Score; D011446:Prospective Studies; D012042:Registries; D020123:Sirolimus / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D000068338:Everolimus; C518022:umirolimus; D020123:Sirolimus