title: Pathogenic role of antibodies against monomeric C-reactive protein in tubulointerstitial nephritis and uveitis syndrome.
abstract: Antibodies against monomeric C-reactive protein, which is a target antigen expressed both in kidney tubules and uveal cells, have been recently detected in patients with active tubulointerstitial nephritis and uveitis syndrome. We report the case of an 65-year-old woman with acute renal failure caused by biopsy-proven tubulointerstitial nephritis and the onset of uveitis 21 months later. The expression of monomeric C-reactive protein in kidney oligobiopsy was confirmed by immunohistochemical staining using mouse monoclonal antibody against human monomeric C-reactive protein. The levels of antibodies against monomeric C-reactive protein were 117% of the reference during the flare and 22% during the remission of the disease. The difference in the levels of antibodies against monomeric C-reactive protein during flare and remission, and above all positive biopsy staining, supports their pathogenic role in this disease.
authors: Department and Clinic of Nephrology and Transplantation Medicine, Wroclaw, Poland.
authors: K
authors: K
authors: Jakuszko
authors: M
authors: M
authors: Krajewska
authors: A
authors: A
authors: Hałoń
authors: K
authors: K
authors: Kościelska-Kasprzak
authors: M
authors: M
authors: Myszka
authors: M
authors: M
authors: Żabińska
authors: H
authors: H
authors: Augustyniak-Bartosik
authors: D
authors: D
authors: Rukasz
authors: W
authors: W
authors: Weyde
authors: M
authors: M
authors: Klinger
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000276:immunology*; D001706:Biopsy; D002097:C-Reactive Protein / Q000276:immunology*; D005260:Female; D006801:Humans; D009395:Nephritis, Interstitial / Q000175:diagnosis / Q000276:immunology*; D013577:Syndrome; D014605:Uveitis / Q000175:diagnosis / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D002097:C-Reactive Protein
keywords: autoantibodies; monomeric CRP; tubulointerstitial nephritis; uveitis