title: Dual therapeutic benefit of electroporation-mediated DNA vaccination in vivo: Enhanced gene transfer and adjuvant activity.
abstract: DNA vaccination consists of administering an antigen-coding nucleotide sequence. In order to improve the efficacy of DNA vaccines, electroporation is one of the most commonly used methods to enhance DNA uptake. Here, we discuss additional immunological effects of electroporation that are key aspects for inducing immunity in response to DNA vaccines.
authors: Univ Paris-Sud; Laboratoire de Vectorologie et Thérapeutiques Anticancéreuses; UMR 8203; Villejuif, France ; CNRS; Laboratoire de Vectorologie et Thérapeutiques Anticancéreuses; UMR 8203; Villejuif, France ; Gustave Roussy; Laboratoire de Vectorologie et Thérapeutiques Anticancéreuses; UMR 8203; Villejuif, France.
authors: Christophe Y
authors: CY
authors: Calvet
authors: Univ Paris-Sud; Laboratoire de Vectorologie et Thérapeutiques Anticancéreuses; UMR 8203; Villejuif, France ; CNRS; Laboratoire de Vectorologie et Thérapeutiques Anticancéreuses; UMR 8203; Villejuif, France ; Gustave Roussy; Laboratoire de Vectorologie et Thérapeutiques Anticancéreuses; UMR 8203; Villejuif, France.
authors: Franck M
authors: FM
authors: André
authors: Univ Paris-Sud; Laboratoire de Vectorologie et Thérapeutiques Anticancéreuses; UMR 8203; Villejuif, France ; CNRS; Laboratoire de Vectorologie et Thérapeutiques Anticancéreuses; UMR 8203; Villejuif, France ; Gustave Roussy; Laboratoire de Vectorologie et Thérapeutiques Anticancéreuses; UMR 8203; Villejuif, France.
authors: Lluis M
authors: LM
authors: Mir
keywords: ATP; DAMPs; T lymphocyte; dendritic cell; electric pulses; electropermeabilization; gene electrotransfer; immunotherapy; non-viral gene therapy