title: Expression of Stathmin1 in gastric adenocarcinoma.
abstract: BACKGROUND
  Over expression of Stathmin1 (STMN1), activation-induced cytidine deaminase (AID) and protein kinase C iota (PKCi) proteins participate in the regulation of carcinogenesis. In the present study, we investigated the expression of STMN1 in patients with gastric adenocarcinoma and also determined the correlation of STMN1 with AID and PKCi proteins.
  
  
  METHODS
  This study was conducted in the Tokushima University Hospital between September 2009 and September 2010 on a total of 59 patients with gastric adenocarcinoma. Stathmin1, AID and PKCi protein expressions were evaluated by immuno-histochemistry in gastric adenocarcinoma.
  
  
  RESULTS
  A strong expression of STMN1 was significantly associated with gender- and poorly differentiated gastric adenocarcinoma (p<0.05). A high mRNA level of STMN1 was found in the tumor tissue of gastric adenocarcinoma compared to non-tumor tissue (p<0.05). In addition, STMN1 expression was significantly correlated with AID and PKCi protein expressions in gastric adenocarcinoma (p<0.05).
  
  
  CONCLUSIONS
  High mRNA level of the Stathmin1 gene was significantly expressed in gastric tumor tissue than non-tumor and strong expression of STMN1 protein is correlated with poorly-differentiated gastric adenocarcinoma.
authors: Department of Surgery, Institute of Health Biosciences, The University of Tokushima, Tokushima, Japan.
authors: Bat-Erdene
authors: BE
authors: Batsaikhan
authors: Department of Surgery, Institute of Health Biosciences, The University of Tokushima, Tokushima, Japan.
authors: Kozo
authors: K
authors: Yoshikawa
authors: Department of Surgery, Institute of Health Biosciences, The University of Tokushima, Tokushima, Japan.
authors: Nobuhiro
authors: N
authors: Kurita
authors: Department of Surgery, Institute of Health Biosciences, The University of Tokushima, Tokushima, Japan.
authors: Takashi
authors: T
authors: Iwata
authors: Department of Surgery, Institute of Health Biosciences, The University of Tokushima, Tokushima, Japan.
authors: Chie
authors: C
authors: Takasu
authors: Department of Surgery, Institute of Health Biosciences, The University of Tokushima, Tokushima, Japan.
authors: Hideya
authors: H
authors: Kashihara
authors: Department of Surgery, Institute of Health Biosciences, The University of Tokushima, Tokushima, Japan mitsuo.shimada@tokushima-u.ac.jp.
authors: Mitsuo
authors: M
authors: Shimada
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003564:Cytidine Deaminase / Q000032:analysis; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000032:analysis; D008297:Male; D008875:Middle Aged; D011493:Protein Kinase C / Q000032:analysis; D012333:RNA, Messenger / Q000032:analysis; D050777:Stathmin / Q000032:analysis / Q000235:genetics*; D013274:Stomach Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D000098830:AICDA (Activation-Induced Cytidine Deaminase); D000099293:Protein Kinase C-lambda
chemical_list: D003564:Cytidine Deaminase; D007527:Isoenzymes; D011493:Protein Kinase C; D012333:RNA, Messenger; D050777:Stathmin; D000098830:AICDA (Activation-Induced Cytidine Deaminase); D000099293:Protein Kinase C-lambda; C493995:STMN1 protein, human
keywords: AID; PKCi; STMN1; gastric adenocarcinoma