title: Ossifying fibromyxoid tumor of the breast mimicking fibroadenoma: a case report and differential diagnoses.
abstract: An 80-year-old woman presented with a palpable mass in the right breast. Mammographic findings were consistent with calcified fibroadenoma. An ultrasound was performed that showed a solid nodule with peripheral calcification. A core biopsy was obtained that revealed a spindle cell proliferation with a shell of mature bone. The histologic features, in combination with immunohistochemical studies, were those of an ossifying fibromyxoid tumor. Complete excision of the specimen further confirmed the diagnosis. To the best of our knowledge, this is the first reported case of ossifying fibromyxoid tumor occurring in the breast. We review the current literature on ossifying fibromyxoid tumor and discuss the differential diagnoses when confronted with bland spindle cells on a core biopsy of the breast.
authors: From the Departments of Pathology (Drs Asirvatham, Shah, Carreon, Bhuiya, and Kahn) and Surgery (Dr Kostroff), Hofstra-North Shore Long Island Jewish School of Medicine, New York, New York; and New York Hospital of Queens, New York-Presbyterian Health Care System, New York (Dr Morgenstern).
authors: Jaya Ruth
authors: JR
authors: Asirvatham
authors: Anand
authors: A
authors: Shah
authors: Chrystalle Katte
authors: CK
authors: Carreon
authors: Tawfiqul A
authors: TA
authors: Bhuiya
authors: Leonard B
authors: LB
authors: Kahn
authors: Karen
authors: K
authors: Kostroff
authors: Nora J
authors: NJ
authors: Morgenstern
mesh_terms: D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D062005:Biopsy, Large-Core Needle; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D002277:Carcinoma / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D018226:Fibroadenoma / Q000175:diagnosis / Q000473:pathology; D005350:Fibroma / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D006801:Humans; D042361:Mammary Glands, Human / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D017520:Mucinoses / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D009999:Ossification, Heterotopic / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor