title: Clinical translation in the virtual liver network.
abstract: The liver is the central detoxifying organ, continuously removing xenobiotics from the vascular system. Given its role in drug metabolism, a functional understanding of liver physiology is crucial to optimizing drug efficacy and patient safety. The Virtual Liver Network (VLN), a German national flagship research program, focuses on producing validated computer models of human liver physiology. These models are used to analyze patient-derived data and thereby gain mechanistic insights in the processes underlying drug pharmacokinetics (PK).
authors: Bayer Technology Services GmbH, Computational Systems Biology, Leverkusen, Germany.
authors: L
authors: L
authors: Kuepfer
authors: Department of Clinical Pharmacology, Dr. Margarete Fischer-Bosch Institute for Clinical Pharmacology, University of Tübingen, Stuttgart, Germany.
authors: R
authors: R
authors: Kerb
authors: Programme Director, Virtual Liver Network, BioQuant/BQ0018, University of Heidelberg, Heidelberg, Germany.
authors: A M
authors: AM
authors: Henney