title: Systematic study on G-protein couple receptor prototypes: did they really evolve from prokaryotic genes?
abstract: G-protein couple receptor (GPCR) is one of the most striking examples of signalling proteins and it is only observed in eukaryotes. Based on various GPCR identification methods and classification systems, several evolutionary presumptions of different GPCR families have been reported. However, the prototype of GPCR still limits our knowledge. By investigating its structure and domain variance, the authors propose that GPCR might be evolved from prokaryotic world. The results given by the authors indicate that metabotropic glutamate receptor family would be the ancestor of GPCR. Phylogenetic analysis hints that one of metabotropic glutamate receptor GABA is possibly formed and evolved from the ancient chemical union of bacteriorhodopsin and periplasmic binding protein. The results obtained by the authors also unprecedentedly demonstrate that specific domains and identical structures are shown in each type of GPCR, which provides unique opportunities for future strategies on GPCR orphans' prediction and classification.
authors: College of Life Science, Graduate University of Chinese Academy of Sciences, No.9A Yuquan Rd, Shijingshan District, Beijing 100049, People's Republic of China.
authors: Zaichao
authors: Z
authors: Zhang
authors: Supercomputing Center, Computer Network Information Center, Chinese Academy of Sciences, No.4, South Four Street Zhongguancun, Haidian District, Beijing 100190, People's Republic of China.
authors: Zhong
authors: Z
authors: Jin
authors: College of Life Science, Graduate University of Chinese Academy of Sciences, No.9A Yuquan Rd, Shijingshan District, Beijing 100049, People's Republic of China.
authors: Yongbing
authors: Y
authors: Zhao
authors: CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, No.1-7, Beichen W Rd, Chaoyang District, Beijing, People's Republic of China, 100101.
authors: Zhewen
authors: Z
authors: Zhang
authors: CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, No.1-7, Beichen W Rd, Chaoyang District, Beijing, People's Republic of China, 100101.
authors: Rujiao
authors: R
authors: Li
authors: CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, No.1-7, Beichen W Rd, Chaoyang District, Beijing, People's Republic of China, 100101.
authors: Jingfa
authors: J
authors: Xiao
authors: CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, No.1-7, Beichen W Rd, Chaoyang District, Beijing, People's Republic of China, 100101. wujy@big.ac.cn.
authors: Jiayan
authors: J
authors: Wu
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D019143:Evolution, Molecular; D006801:Humans; D008956:Models, Chemical; D008957:Models, Genetic; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics; D011387:Prokaryotic Cells / Q000502:physiology*; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry* / Q000235:genetics*
chemical_list: D043562:Receptors, G-Protein-Coupled