title: Liver fibrosis evaluation by ARFI and APRI in chronic hepatitis C.
abstract: OBJECTIVE
  To explore the value of liver fibrosis assessment by acoustic radiation force impulse (ARFI) and the AST/PLT ratio index (APRI) in chronic hepatitis C patients.
  
  
  METHODS
  One hundred and twenty eight patients with chronic hepatitis C were examined using ARFI elastometry and APRI, calculated according to known formulae. The gold standard of liver biopsy was referred; ROC curve analysis was used to assess all ARFI and APRI values. The corresponding cut-off values, sensitivities, and specificities were calculated and compared. In addition, the correlation of liver fibrosis stages in chronic hepatitis C patients with ARFI measurements and APRI were also tested to evaluate significant data.
  
  
  RESULTS
  The values of ARFI in S1-S4 were 1.23 ± 0.34 m/s, 1.48 ± 0.43 m/s, 2.06 ± 0.45 m/s, and 2.30 ± 0.87 m/s. The values of APRI in S1-S4 were 0.31 ± 0.45 m/s, 0.28 ± 0.38 m/s, 0.58 ± 0.59 m/s and 0.65 ± 0.34 m/s. ARFI (r = 0.649, P < 0.05) showed a better correlation with liver fibrosis stages in chronic hepatitis C than APRI (r = 0.478, P < 0.05). The areas under the ROC curves for ARFI and APRI were 0.775 and 0.721 for stages ≥ S2, 0.901 and 0.787 for stages ≥ S3, and 0.792 and 0.780 for S = 4, respectively.
  
  
  CONCLUSIONS
  Both ARFI and APRI could evaluate liver fibrosis stages in chronic hepatitis C. ARFI is more accurate than the APRI index.
authors: Su-Mei Li, Guang-Xia Li, Dong-Mei Fu, Yu Wang, Li-Qun Dang, Department of Physical Diagnosis B Ultrasound Room, Daqing Longnan Hospital, Qiqihar Medical College Affiliated Fifth Hospital, Daqing 163453, Heilongjiang Province, China.
authors: Su-Mei
authors: SM
authors: Li
authors: Su-Mei Li, Guang-Xia Li, Dong-Mei Fu, Yu Wang, Li-Qun Dang, Department of Physical Diagnosis B Ultrasound Room, Daqing Longnan Hospital, Qiqihar Medical College Affiliated Fifth Hospital, Daqing 163453, Heilongjiang Province, China.
authors: Guang-Xia
authors: GX
authors: Li
authors: Su-Mei Li, Guang-Xia Li, Dong-Mei Fu, Yu Wang, Li-Qun Dang, Department of Physical Diagnosis B Ultrasound Room, Daqing Longnan Hospital, Qiqihar Medical College Affiliated Fifth Hospital, Daqing 163453, Heilongjiang Province, China.
authors: Dong-Mei
authors: DM
authors: Fu
authors: Su-Mei Li, Guang-Xia Li, Dong-Mei Fu, Yu Wang, Li-Qun Dang, Department of Physical Diagnosis B Ultrasound Room, Daqing Longnan Hospital, Qiqihar Medical College Affiliated Fifth Hospital, Daqing 163453, Heilongjiang Province, China.
authors: Yu
authors: Y
authors: Wang
authors: Su-Mei Li, Guang-Xia Li, Dong-Mei Fu, Yu Wang, Li-Qun Dang, Department of Physical Diagnosis B Ultrasound Room, Daqing Longnan Hospital, Qiqihar Medical College Affiliated Fifth Hospital, Daqing 163453, Heilongjiang Province, China.
authors: Li-Qun
authors: LQ
authors: Dang
mesh_terms: D000368:Aged; D019540:Area Under Curve; D001219:Aspartate Aminotransferases / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D004796:Clinical Enzyme Tests; D054459:Elasticity Imaging Techniques; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications*; D006801:Humans; D008099:Liver / Q000201:enzymology* / Q000473:pathology*; D008103:Liver Cirrhosis / Q000097:blood / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D008297:Male; D010976:Platelet Count; D011237:Predictive Value of Tests; D012372:ROC Curve; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D001219:Aspartate Aminotransferases
keywords: AST/PLT ratio index; Acoustic radiation force impulse; Chronic hepatitis C; Liver fibrosis; Sensitivity; Specificity