title: [The fatty acids of membranes of erythrocytes in women with ischemic heart disease under effect of statins].
abstract: The technique of evaluation of metabolism of fatty acids in vivo consists in detection of content of fatty acids in phospholipids of membranes of erythrocytes. The fatty acids are received with food, through synthesis on liver from carbohydrates and by katabolism of very long-chain polyolefinic fatty acids of food in peroxisomes of hepatocytes (oxidation, saturation and desaturation). In position sn-1 phospholipids more often than palmitic fatty acid (14%) stearic fatty acid is esterified (21% of all fatty acids). The palmitic, stearic and lignoceric saturated fatty acids are esterified into sn-1 phospholipids as 2:3:1. The simvastatin (80 mg per day) increased content of margarine, tricosanoic and hexacosanoic fatty acids by decrease of level of palmitic fatty acid. The ratio omega-3 polyolefinic fatty acids/omega-6 polyolefinic fatty acids reliably increased. The statins increase content of omega-3 polyolefinic fatty acids. In practice, it is necessary to differentiate the terms "atherosclerosis" and "atheromatosis". The atherosclerosis is a syndrome of intracellular deficiency of polyolefinic fatty acids, derangement of function of cells in vivo under decrease of biological availability for all cells (absorption blockage). The atheromatosis is such most significant clinically symptom of atherosclerosis as accumulation of non-saturated and polyolefinic fatty acids in pool of collection and utilization of biological "garbage" from blood plasma, in intima of elastic type arteries. The statins activate absorption of low density lipoproteins by cells and normalize biological availability of polyolefinic fatty acids which have a positive effect under atherosclerosis and on formation of atheromatosis.
authors: A M
authors: AM
authors: Dygaĭ
authors: M Iu
authors: MIu
authors: Kotlovskiĭ
authors: D A
authors: DA
authors: Kirichenko
authors: I Iu
authors: IIu
authors: Iakimovich
authors: D S
authors: DS
authors: Trereshina
authors: Iu V
authors: IuV
authors: Kotlovskiĭ
authors: V N
authors: VN
authors: Titiov
mesh_terms: D004910:Erythrocyte Membrane / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage*; D050356:Lipid Metabolism / Q000187:drug effects*; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000378:metabolism*; D058226:Plaque, Atherosclerotic / Q000188:drug therapy / Q000378:metabolism
chemical_list: D005227:Fatty Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors