title: [Treatment of pulmonary arterial hypertension].
abstract: Treatment of pulmonary arterial hypertension has achieved significant progress over the past 20 years. Currently, 3 groups of drugs have proven useful for the treatment of this disease: endothelin receptor antagonist, phosphodiesterase inhibitors and prostacyclin and its analogues. It is recommended to initiate treatment with one of these drugs, the choice depending on the initial severity of patient disease and the preferences of the treating physician. When the patient does not have a satisfactory response, new drugs acting at a different pathway are most commonly added. At this time, considering referral for lung transplantation could be an alternative. Most experts recommend grouping maximum experience in what is known as expert centers. Treatment has led to better survival in these patients, but there is still a long way to cure this life-threatening disease.
authors: Servicio de Neumología, Hospital Universitario Vall d'Hebron, Barcelona, España; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, España. Electronic address: aroman@vhebron.net.
authors: Antonio
authors: A
authors: Roman
authors: Servicio de Neumología, Hospital Universitario Vall d'Hebron, Barcelona, España; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, España.
authors: Manuel
authors: M
authors: López-Meseguer
authors: Servicio de Cardiología, Hospital Universitario Vall d'Hebron, Barcelona, España; Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Barcelona, Barcelona, España.
authors: Enric
authors: E
authors: Domingo
mesh_terms: D002986:Clinical Trials as Topic; D019468:Disease Management; D004359:Drug Therapy, Combination; D065128:Endothelin Receptor Antagonists / Q000627:therapeutic use*; D017079:Exercise Tolerance; D006162:Guanylate Cyclase / Q000187:drug effects; D006325:Heart Atria / Q000601:surgery; D006346:Heart Septum / Q000601:surgery; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D008019:Life Style; D016040:Lung Transplantation; D010166:Palliative Care; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use*; D044062:Prostaglandins I / Q000819:agonists / Q000627:therapeutic use*
chemical_list: D065128:Endothelin Receptor Antagonists; D010726:Phosphodiesterase Inhibitors; D044062:Prostaglandins I; D006162:Guanylate Cyclase
keywords: Hipertensión arterial pulmonar; Hipertensión pulmonar; Lung transplantation; Pulmonary arterial hypertension; Pulmonary hypertension; Trasplante pulmonar