title: 'Silent' mitral cells dominate odor responses in the olfactory bulb of awake mice.
abstract: How wakefulness shapes neural activity is a topic of intense discussion. In the awake olfactory bulb, high activity with weak sensory-evoked responses has been reported in mitral/tufted cells (M/TCs). Using blind whole-cell recordings, we found 33% of M/TCs to be 'silent', yet still show strong sensory responses, with weak or inhibitory responses in 'active' neurons. Thus, a previously missed M/TC subpopulation can exert powerful influence over the olfactory bulb.
authors: 1] Behavioural Neurophysiology, Max Planck Institute for Medical Research, Heidelberg, Germany. [2] Division of Neurophysiology, MRC National Institute for Medical Research, London, UK.
authors: Mihaly
authors: M
authors: Kollo
authors: 1] Behavioural Neurophysiology, Max Planck Institute for Medical Research, Heidelberg, Germany. [2] Department of Anatomy and Cell Biology, Faculty of Medicine, University of Heidelberg, Heidelberg, Germany.
authors: Anja
authors: A
authors: Schmaltz
authors: 1] Behavioural Neurophysiology, Max Planck Institute for Medical Research, Heidelberg, Germany. [2] Department of Anatomy and Cell Biology, Faculty of Medicine, University of Heidelberg, Heidelberg, Germany.
authors: Mostafa
authors: M
authors: Abdelhamid
authors: 1] Behavioural Neurophysiology, Max Planck Institute for Medical Research, Heidelberg, Germany. [2] Division of Neurophysiology, MRC National Institute for Medical Research, London, UK.
authors: Izumi
authors: I
authors: Fukunaga
authors: 1] Behavioural Neurophysiology, Max Planck Institute for Medical Research, Heidelberg, Germany. [2] Division of Neurophysiology, MRC National Institute for Medical Research, London, UK. [3] Department of Anatomy and Cell Biology, Faculty of Medicine, University of Heidelberg, Heidelberg, Germany. [4] Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK.
authors: Andreas T
authors: AT
authors: Schaefer
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D004558:Electric Stimulation; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000502:physiology*; D009812:Odorants; D009830:Olfactory Bulb / Q000166:cytology*; D018408:Patch-Clamp Techniques; D014851:Wakefulness / Q000502:physiology*