title: Successful hematopoietic reconstitution by unrelated donor cord blood transplantation in children with Fanconi anemia: report of 3 cases.
abstract: To potentially reduce late effects of malignancy and chronic graft-versus-host disease in patients with Fanconi anemia, 3 patients received unmanipulated umbilical cord blood grafts with 0 or 1 HLA antigen mismatch. The conditioning regimen consisted of fludarabine (30 mg/m/d) for 6 days, cyclophosphamide (60 mg/kg/d) for 2 days, and rabbit antithymocyte globulin (ATG) (2.5 mg/kg/d) for 3 days. Radiation was not used in the preparative regimen. None of the patients had significant conditioning-related toxicity. All were engrafted within 10 to 19 days. All patients are well with stable or full donor chimerism after a median follow-up of 64 months (range, 13 to 69 mo).
authors: *Department of Pediatrics, Division of Hematology/Oncology, Chang Gung Children's Hospital, Chang Gung University †Department of Pathology, Chang Gung Memorial Hospital, Chang Gung University, Linkou, Taoyuan, Taiwan.
authors: Tang-Her
authors: TH
authors: Jaing
authors: Shih-Hsiang
authors: SH
authors: Chen
authors: Chao-Ping
authors: CP
authors: Yang
authors: Iou-Jih
authors: IJ
authors: Hung
authors: Tsung-Yen
authors: TY
authors: Chang
authors: Chuen
authors: C
authors: Hsueh
mesh_terms: D000818:Animals; D000961:Antilymphocyte Serum / Q000008:administration & dosage; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage; D002675:Child, Preschool; D002908:Chronic Disease; D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects* / Q000379:methods*; D003520:Cyclophosphamide / Q000008:administration & dosage; D005199:Fanconi Anemia / Q000628:therapy*; D006086:Graft vs Host Disease / Q000628:therapy*; D006410:Hematopoiesis / Q000187:drug effects*; D006650:Histocompatibility Testing; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007223:Infant; D008297:Male; D019653:Myeloablative Agonists / Q000008:administration & dosage; D011817:Rabbits; D019172:Transplantation Conditioning / Q000379:methods*; D014184:Transplantation, Homologous; D014740:Vidarabine / Q000008:administration & dosage / Q000031:analogs & derivatives
chemical_list: D000961:Antilymphocyte Serum; D018906:Antineoplastic Agents, Alkylating; D007166:Immunosuppressive Agents; D019653:Myeloablative Agonists; D003520:Cyclophosphamide; D014740:Vidarabine; C024352:fludarabine