title: Prognostic usefulness of IL-6 and VEGF for the occurrence of changes in coronary arteries of patients with stable angina and implanted stents.
abstract: OBJECTIVE
  The aim of this study was to determine the prognostic significance of interleukin 6 (IL-6) and vascular endothelial growth factor (VEGF) in patients with chronic coronary artery disease treated who underwent percutaneous coronary intervention with stent implantation, for assessing the risk of restenosis and the occurrence of de novo lesions.
  
  
  METHODS
  498 patients with stable angina were examined during 18 months. 50 patients with significant (> 70%) stenosis of one coronary artery, eligible for the implantation of one stent, were enrolled to the study. Il-6 and VEGF level was measured using ELISA immunoassays during the initial coronary angiography with simultaneous angioplasty and stent implantation and 4 weeks after stent implantation. Coronary angiography was carried out 8-12 months after stent implantation.
  
  
  RESULTS
  Statistically significant increase in IL-6 (from 4.02 ± 4.40 to 10.90 ± 8.23) and VEGF (from 310.13 ± 50.90 to 392.32 ± 106.84) level was observed 4 weeks after stent implantation in the group with restenosis.
  
  
  CONCLUSIONS
  Increased levels of IL-6 and VEGF in the peripheral blood of patients with chronic stable angina pectoris, measured 4 weeks after coronary angioplasty with stent implantation, may indicate an increased risk of angiographic restenosis and de novo coronary artery lesions.
authors: Department of Clinical Pharmacology, Poznan University of Medical Sciences, Poznan, Poland. artcies@ump.edu.pl.
authors: E
authors: E
authors: Kazmierczak
authors: S
authors: S
authors: Grajek
authors: J
authors: J
authors: Kowal
authors: E
authors: E
authors: Chmara
authors: M
authors: M
authors: Grygier
authors: M
authors: M
authors: Pyda
authors: P
authors: P
authors: Bogdanski
authors: A
authors: A
authors: Cieslewicz
authors: A
authors: A
authors: Jablecka
mesh_terms: D000787:Angina Pectoris / Q000378:metabolism / Q000473:pathology; D060050:Angina, Stable / Q000378:metabolism* / Q000473:pathology; D015906:Angioplasty, Balloon, Coronary / Q000379:methods; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000378:metabolism* / Q000473:pathology; D003331:Coronary Vessels / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015607:Stents; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A