title: [Genotoxicity evaluation of nanoparticles].
abstract: There are considered the results of studies of genotoxicity of nanoparticles with an emphasis on studies in vivo. Oxidative stress was determined as a general mechanism genotoxicity of nanoparticles defined. There are reported the practical considerations relating to the genotoxic assessment of nanoparticles. In particular there was pointed out the priority of research in vivo, there was indicated to a possible dependence of the manifestation of effects as well on the properties of nanoparticles, as the timing of exposure, dose, route of administration, the peculiarities of the sample preparation. There was noted the desirability of the usage of positive controls in experiments. As tasks requiring solutions, there were separated the assessment of the ability of nanoparticles to the induction of gene mutations and evaluation of their genotoxic effects in embryonic and germ cells. There was given a conclusion on the general state of the problem and there were identified the priorities of research in genotoxicology of nanoparticles.
authors: A D
authors: AD
authors: Durnev
mesh_terms: D004305:Dose-Response Relationship, Drug; D006801:Humans; D009152:Mutagenicity Tests / Q000379:methods*; D009153:Mutagens / Q000633:toxicity*; D009154:Mutation; D053758:Nanoparticles / Q000008:administration & dosage / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects; D013997:Time Factors
chemical_list: D009153:Mutagens