title: Effectiveness of intraoperative indocyanine-green fluorescence angiography during inguinal lymph node dissection for skin cancer to prevent postoperative wound dehiscence.
abstract: OBJECTIVE
  The incidence of postoperative wound dehiscence following inguinal lymph node dissection (ILND) is higher than that in other anatomic regions. To prevent wound dehiscence, intraoperative interventions, such as trimming off the ischemic part of the flap before wound closure based on indocyanine-green (ICG) fluorescence angiography, have been introduced in our institute. This report describes a retrospective clinical study of 17 cases, and the objective of the study was to evaluate the clinical efficacy of intraoperative intervention using ICG fluorescence angiography.
  
  
  METHODS
  A total of 17 patients who underwent ILND for skin cancer between 2009 and 2013 at our institute were reviewed retrospectively, and the significance of variables, including intervention using ICG fluorescence angiography, was evaluated using Fisher's exact test.
  
  
  RESULTS
  There were nine cases of wound dehiscence, and two of these cases required a secondary skin graft. Only one case of wound dehiscence developed in the eight patients who underwent intervention based on ICG fluorescence angiography. This procedure was a significant factor influencing the risk of wound dehiscence (p = 0.003) in our study.
  
  
  CONCLUSIONS
  Although this was a small case series, intraoperative intervention based on ICG fluorescence angiography was effective for preventing postoperative wound dehiscence after ILND.
authors: Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Hokkaido at Sapporo, Kita-15, Nishi-8, Kita-ku, Sapporo, Hokkaido, 060-8638, Japan, hfuru@med.hokudai.ac.jp.
authors: Hiroshi
authors: H
authors: Furukawa
authors: Toshihiko
authors: T
authors: Hayashi
authors: Akihiko
authors: A
authors: Oyama
authors: Emi
authors: E
authors: Funayama
authors: Naoki
authors: N
authors: Murao
authors: Takeshi
authors: T
authors: Yamao
authors: Yuhei
authors: Y
authors: Yamamoto
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods*; D006801:Humans; D007208:Indocyanine Green; D007264:Inguinal Canal; D007430:Intraoperative Care; D007432:Intraoperative Period; D008197:Lymph Node Excision / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000601:surgery*; D025321:Surgery, Computer-Assisted / Q000379:methods*; D013529:Surgical Wound Dehiscence / Q000517:prevention & control*
chemical_list: D007208:Indocyanine Green