title: Mitochondrial genome sequence diversity of Indian Plasmodium falciparum isolates.
abstract: We have analysed the whole mitochondrial (mt) genome sequences (each ~6 kilo nucleotide base pairs in length) of four field isolates of the malaria parasite Plasmodium falciparum collected from different locations in India. Comparative genomic analyses of mt genome sequences revealed three novel India-specific single nucleotide polymorphisms. In general, high mt genome diversity was found in Indian P. falciparum, at a level comparable to African isolates. A population phylogenetic tree placed the presently sequenced Indian P. falciparum with the global isolates, while a previously sequenced Indian isolate was an outlier. Although this preliminary study is limited to a few numbers of isolates, the data have provided fundamental evidence of the mt genome diversity and evolutionary relationships of Indian P. falciparum with that of global isolates.
authors: Evolutionary Genomics and Bioinformatics Laboratory, Division of Genomics and Bioinformatics, National Institute of Malaria Research, New Delhi, India.
authors: Suchi
authors: S
authors: Tyagi
authors: Department of Biotechnology, Kumaun University, Nainital, India.
authors: Veena
authors: V
authors: Pande
authors: Evolutionary Genomics and Bioinformatics Laboratory, Division of Genomics and Bioinformatics, National Institute of Malaria Research, New Delhi, India.
authors: Aparup
authors: A
authors: Das
mesh_terms: D000349:Africa; D001483:Base Sequence; D016054:DNA, Protozoan / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics*; D054629:Genome, Mitochondrial / Q000235:genetics*; D006239:Haplotypes; D007194:India; D010802:Phylogeny; D010963:Plasmodium falciparum / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D015800:Protozoan Proteins / Q000235:genetics*; D016415:Sequence Alignment
chemical_list: D016054:DNA, Protozoan; D015800:Protozoan Proteins