title: Assessment of β-zone peripapillary atrophy by optical coherence tomography and scanning laser ophthalmoscopy imaging in glaucoma patients.
abstract: OBJECTIVE
  To assess β-zone peripapillary atrophy (β-PPA) using spectral domain optical coherence tomography (SD-OCT), scanning laser ophthalmoscopy (SLO), and fundus auto-fluorescence (FAF) imaging in patients with primary open-angle glaucoma with advanced glaucomatous visual field defects.
  
  
  METHODS
  A consecutive, prospective series of 82 study eyes with primary open-angle glaucoma were included in this study. All study participants underwent a full ophthalmic examination followed by SD-OCT, wide-field SLO, and FAF imaging of the optic nerve head and the peripapillary region.
  
  
  RESULTS
  Eighty-four glaucomatous eyes were included in our prospective study. Correlation analyses for horizontally and vertically obtained β-PPA for all three imaging modalities (color SLO, FAF, and SD-OCT) revealed highest correlations between FAF and color SLO (Pearson correlation coefficient: 0.904 [P<0.001] for horizontal β-PPA and 0.786 [P<0.001] for vertical β-PPA). Bland-Altman plotting revealed highest agreements between color SLO and FAF, with -2.1 pixels ±1.96 standard deviation (SD) for horizontal β-PPA, SD: 10.5 pixels and 2.4 pixels ±1.96 SD for vertical β-PPA.
  
  
  CONCLUSIONS
  β-PPA can be assessed using en-face SLO and cross-sectional SD-OCT imaging. Correlation analyses revealed highest correlations between color SLO and FAF imaging, while correlations between SLO and SD-OCT were weak. A more precise structural definition of β-PPA is needed.
authors: Department of Ophthalmology, Hannover Medical School, Hannover, Germany.
authors: Florian
authors: F
authors: Seidensticker
authors: Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.
authors: Lukas
authors: L
authors: Reznicek
authors: Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.
authors: Thomas
authors: T
authors: Mann
authors: Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.
authors: Irene
authors: I
authors: Hübert
authors: Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.
authors: Anselm
authors: A
authors: Kampik
authors: Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.
authors: Michael
authors: M
authors: Ulbig
authors: Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.
authors: Christoph
authors: C
authors: Hirneiss
authors: Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.
authors: Aljoscha S
authors: AS
authors: Neubauer
authors: Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.
authors: Marcus
authors: M
authors: Kernt
keywords: FAF; OCT; SD-OCT; SLO; fundus autofluorescence; glaucomatous optic neuropathy