title: One-pot synthesis of 1,4-disubstituted pyrazoles from arylglycines via copper-catalyzed sydnone-alkyne cycloaddition reaction.
abstract: A robust method for constructing 1,4-pyrazoles from arylglycines was developed using the copper-catalyzed sydnone-alkyne cycloaddition reaction. The procedure offers a straightforward and general route to the pyrazole heterocycle through a three-step one-pot procedure.
authors: CEA, iBiTecS , Service de Chimie Bioorganique et de Marquage, Gif sur Yvette, F-91191, France.
authors: Simon
authors: S
authors: Specklin
authors: Elodie
authors: E
authors: Decuypere
authors: Lucie
authors: L
authors: Plougastel
authors: Soifia
authors: S
authors: Aliani
authors: Frédéric
authors: F
authors: Taran
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D061565:Cycloaddition Reaction; D005998:Glycine / Q000031:analogs & derivatives / Q000737:chemistry*; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D013558:Sydnones / Q000737:chemistry
chemical_list: D000480:Alkynes; D011720:Pyrazoles; D013558:Sydnones; D003300:Copper; D005998:Glycine