title: Acute chagas disease: new global challenges for an old neglected disease.
abstract: Chagas disease is caused by infection with the protozoan Trypanosoma cruzi, and although over 100 years have passed since the discovery of Chagas disease, it still presents an increasing problem for global public health. A plethora of information concerning the chronic phase of human Chagas disease, particularly the severe cardiac form, is available in the literature. However, information concerning events during the acute phase of the disease is scarce. In this review, we will discuss (1) the current status of acute Chagas disease cases globally, (2) the immunological findings related to the acute phase and their possible influence in disease outcome, and (3) reactivation of Chagas disease in immunocompromised individuals, a key point for transplantation and HIV infection management.
authors: Department of Morphology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
authors: Daniela V
authors: DV
authors: Andrade
authors: National Institute for Science and Technology in Tropical Diseases, INCT-DT, Belo Horizonte, Minas Gerais, Brazil; Hospital Santa Casa-BH, Institute for Education and Research, Graduate Program in Biomedicine and Medicine, Belo Horizonte, Minas Gerais, Brazil.
authors: Kenneth J
authors: KJ
authors: Gollob
authors: Department of Morphology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; National Institute for Science and Technology in Tropical Diseases, INCT-DT, Belo Horizonte, Minas Gerais, Brazil.
authors: Walderez O
authors: WO
authors: Dutra
mesh_terms: D014355:Chagas Disease / Q000453:epidemiology* / Q000276:immunology / Q000473:pathology*; D014943:Global Health; D006801:Humans; D058069:Neglected Diseases / Q000453:epidemiology* / Q000276:immunology / Q000473:pathology*; D012008:Recurrence; D019371:Topography, Medical; D014349:Trypanosoma cruzi / Q000276:immunology / Q000302:isolation & purification*