title: Frovatriptan 2.5 mg plus dexketoprofen (25 mg or 37.5 mg) in menstrually related migraine. Subanalysis from a double-blind, randomized trial.
abstract: OBJECTIVE
  The purpose of this article is to investigate the efficacy and safety of frovatriptan plus dexketoprofen 25 or 37.5 mg (FroDex25 or FroDex37.5, respectively) compared to that of frovatriptan 2.5 mg (Frova) in menstrually related migraine (MRM).
  
  
  OBJECTIVE
  The aim of this article is to analyze a subgroup of 76 women who treated an MRM attack in this multicenter, randomized, double-blind, parallel-group study.
  
  
  METHODS
  The primary end-point was the proportion of patients who were pain free (PF) at two hours. Secondary end-points included pain-relief (PR) at two hours and 48 hours sustained pain free (SPF).
  
  
  RESULTS
  PF rates at two hours were 29% under Frova, 48% under FroDex25 and 64% under FroDex37.5 (p < 0.05). PR at two hours was Frova 52%, FroDex25 81% and FroDex37.5 88%, while 48 hours SPF was 18% under Frova, 30% under FroDex25 and 44% under FroDex37.5.
  
  
  CONCLUSIONS
  Combining frovatriptan+dexketoprofen produced higher PF rates at two hours compared to Frova while maintaining efficacy at 48 hours. Tolerability profiles were comparable.
authors: Women's Headache Center, Department of Surgical Sciences, University of Turin, Italy gb.allais@tiscali.it.
authors: G
authors: G
authors: Allais
authors: Department of Clinical Neuroscience, National Neurological Institute Carlo Besta, Italy.
authors: G
authors: G
authors: Bussone
authors: Department of Clinical Neuroscience, National Neurological Institute Carlo Besta, Italy.
authors: V
authors: V
authors: Tullo
authors: Neurological Clinic, Department of Biomedical and Neuromotor Sciences, University of Bologna, Italy and IRCCS Institute of Neurological Sciences of Bologna, Bologna, Italy.
authors: P
authors: P
authors: Cortelli
authors: Sestri Ponente Hospital "Padre Antero Micone", Italy.
authors: F
authors: F
authors: Valguarnera
authors: Unit for Treatment and Research of Headaches and Pain, IRCCS San Raffaele Pisana, Italy.
authors: P
authors: P
authors: Barbanti
authors: Sant'Andrea Hospital, Italy.
authors: G
authors: G
authors: Sette
authors: San Giuseppe Moscati Hospital, Italy.
authors: F
authors: F
authors: D'Onofrio
authors: Department of Clinical Neuroscience, National Neurological Institute Carlo Besta, Italy.
authors: M
authors: M
authors: Curone
authors: Women's Headache Center, Department of Surgical Sciences, University of Turin, Italy.
authors: C
authors: C
authors: Benedetto
mesh_terms: D000328:Adult; D000700:Analgesics / Q000008:administration & dosage* / Q000009:adverse effects; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects; D002227:Carbazoles / Q000008:administration & dosage / Q000009:adverse effects; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008599:Menstruation Disturbances / Q000150:complications / Q000188:drug therapy*; D008881:Migraine Disorders / Q000188:drug therapy* / Q000209:etiology; D017366:Serotonin Receptor Agonists / Q000008:administration & dosage / Q000009:adverse effects; D014363:Tryptamines / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002227:Carbazoles; D017366:Serotonin Receptor Agonists; D014363:Tryptamines; C108128:frovatriptan
keywords: Frovatriptan; dexketoprofen; menstrually related migraine; migraine attacks