title: Adipose tissue and vascular inflammation in coronary artery disease.
abstract: Obesity has become an important public health issue in Western and developing countries, with well known metabolic and cardiovascular complications. In the last decades, evidence have been growing about the active role of adipose tissue as an endocrine organ in determining these pathological consequences. As a consequence of the expansion of fat depots, in obese subjects, adipose tissue cells develope a phenotypic modification, which turns into a change of the secretory output. Adipocytokines produced by both adipocytes and adipose stromal cells are involved in the modulation of glucose and lipid handling, vascular biology and, moreover, participate to the systemic inflammatory response, which characterizes obesity and metabolic syndrome. This might represent an important pathophysiological link with atherosclerotic complications and cardiovascular events. A great number of adipocytokines have been described recently, linking inflammatory mileu and vascular pathology. The understanding of these pathways is crucial not only from a pathophysiological point of view, but also to a better cardiovascular disease risk stratification and to the identification of possible therapeutic targets. The aim of this paper is to review the role of Adipocytokines as a possible link between obesity and vascular disease.
authors: Enrica Golia, Giuseppe Limongelli, Francesco Natale, Fabio Fimiani, Valeria Maddaloni, Pina Elvira Russo, Lucia Riegler, Renatomaria Bianchi, Mario Crisci, Gaetano Di Palma, Paolo Golino, Maria Giovanna Russo, Raffaele Calabrò, Paolo Calabrò, Division of Cardiology, Cardio-thoracic and Respiratory Sciences Department, Second University of Naples, AO Dei Colli-Monaldi Hospital, 80131 Naples, Italy.
authors: Enrica
authors: E
authors: Golia
authors: Enrica Golia, Giuseppe Limongelli, Francesco Natale, Fabio Fimiani, Valeria Maddaloni, Pina Elvira Russo, Lucia Riegler, Renatomaria Bianchi, Mario Crisci, Gaetano Di Palma, Paolo Golino, Maria Giovanna Russo, Raffaele Calabrò, Paolo Calabrò, Division of Cardiology, Cardio-thoracic and Respiratory Sciences Department, Second University of Naples, AO Dei Colli-Monaldi Hospital, 80131 Naples, Italy.
authors: Giuseppe
authors: G
authors: Limongelli
authors: Enrica Golia, Giuseppe Limongelli, Francesco Natale, Fabio Fimiani, Valeria Maddaloni, Pina Elvira Russo, Lucia Riegler, Renatomaria Bianchi, Mario Crisci, Gaetano Di Palma, Paolo Golino, Maria Giovanna Russo, Raffaele Calabrò, Paolo Calabrò, Division of Cardiology, Cardio-thoracic and Respiratory Sciences Department, Second University of Naples, AO Dei Colli-Monaldi Hospital, 80131 Naples, Italy.
authors: Francesco
authors: F
authors: Natale
authors: Enrica Golia, Giuseppe Limongelli, Francesco Natale, Fabio Fimiani, Valeria Maddaloni, Pina Elvira Russo, Lucia Riegler, Renatomaria Bianchi, Mario Crisci, Gaetano Di Palma, Paolo Golino, Maria Giovanna Russo, Raffaele Calabrò, Paolo Calabrò, Division of Cardiology, Cardio-thoracic and Respiratory Sciences Department, Second University of Naples, AO Dei Colli-Monaldi Hospital, 80131 Naples, Italy.
authors: Fabio
authors: F
authors: Fimiani
authors: Enrica Golia, Giuseppe Limongelli, Francesco Natale, Fabio Fimiani, Valeria Maddaloni, Pina Elvira Russo, Lucia Riegler, Renatomaria Bianchi, Mario Crisci, Gaetano Di Palma, Paolo Golino, Maria Giovanna Russo, Raffaele Calabrò, Paolo Calabrò, Division of Cardiology, Cardio-thoracic and Respiratory Sciences Department, Second University of Naples, AO Dei Colli-Monaldi Hospital, 80131 Naples, Italy.
authors: Valeria
authors: V
authors: Maddaloni
authors: Enrica Golia, Giuseppe Limongelli, Francesco Natale, Fabio Fimiani, Valeria Maddaloni, Pina Elvira Russo, Lucia Riegler, Renatomaria Bianchi, Mario Crisci, Gaetano Di Palma, Paolo Golino, Maria Giovanna Russo, Raffaele Calabrò, Paolo Calabrò, Division of Cardiology, Cardio-thoracic and Respiratory Sciences Department, Second University of Naples, AO Dei Colli-Monaldi Hospital, 80131 Naples, Italy.
authors: Pina Elvira
authors: PE
authors: Russo
authors: Enrica Golia, Giuseppe Limongelli, Francesco Natale, Fabio Fimiani, Valeria Maddaloni, Pina Elvira Russo, Lucia Riegler, Renatomaria Bianchi, Mario Crisci, Gaetano Di Palma, Paolo Golino, Maria Giovanna Russo, Raffaele Calabrò, Paolo Calabrò, Division of Cardiology, Cardio-thoracic and Respiratory Sciences Department, Second University of Naples, AO Dei Colli-Monaldi Hospital, 80131 Naples, Italy.
authors: Lucia
authors: L
authors: Riegler
authors: Enrica Golia, Giuseppe Limongelli, Francesco Natale, Fabio Fimiani, Valeria Maddaloni, Pina Elvira Russo, Lucia Riegler, Renatomaria Bianchi, Mario Crisci, Gaetano Di Palma, Paolo Golino, Maria Giovanna Russo, Raffaele Calabrò, Paolo Calabrò, Division of Cardiology, Cardio-thoracic and Respiratory Sciences Department, Second University of Naples, AO Dei Colli-Monaldi Hospital, 80131 Naples, Italy.
authors: Renatomaria
authors: R
authors: Bianchi
authors: Enrica Golia, Giuseppe Limongelli, Francesco Natale, Fabio Fimiani, Valeria Maddaloni, Pina Elvira Russo, Lucia Riegler, Renatomaria Bianchi, Mario Crisci, Gaetano Di Palma, Paolo Golino, Maria Giovanna Russo, Raffaele Calabrò, Paolo Calabrò, Division of Cardiology, Cardio-thoracic and Respiratory Sciences Department, Second University of Naples, AO Dei Colli-Monaldi Hospital, 80131 Naples, Italy.
authors: Mario
authors: M
authors: Crisci
authors: Enrica Golia, Giuseppe Limongelli, Francesco Natale, Fabio Fimiani, Valeria Maddaloni, Pina Elvira Russo, Lucia Riegler, Renatomaria Bianchi, Mario Crisci, Gaetano Di Palma, Paolo Golino, Maria Giovanna Russo, Raffaele Calabrò, Paolo Calabrò, Division of Cardiology, Cardio-thoracic and Respiratory Sciences Department, Second University of Naples, AO Dei Colli-Monaldi Hospital, 80131 Naples, Italy.
authors: Gaetano Di
authors: GD
authors: Palma
authors: Enrica Golia, Giuseppe Limongelli, Francesco Natale, Fabio Fimiani, Valeria Maddaloni, Pina Elvira Russo, Lucia Riegler, Renatomaria Bianchi, Mario Crisci, Gaetano Di Palma, Paolo Golino, Maria Giovanna Russo, Raffaele Calabrò, Paolo Calabrò, Division of Cardiology, Cardio-thoracic and Respiratory Sciences Department, Second University of Naples, AO Dei Colli-Monaldi Hospital, 80131 Naples, Italy.
authors: Paolo
authors: P
authors: Golino
authors: Enrica Golia, Giuseppe Limongelli, Francesco Natale, Fabio Fimiani, Valeria Maddaloni, Pina Elvira Russo, Lucia Riegler, Renatomaria Bianchi, Mario Crisci, Gaetano Di Palma, Paolo Golino, Maria Giovanna Russo, Raffaele Calabrò, Paolo Calabrò, Division of Cardiology, Cardio-thoracic and Respiratory Sciences Department, Second University of Naples, AO Dei Colli-Monaldi Hospital, 80131 Naples, Italy.
authors: Maria Giovanna
authors: MG
authors: Russo
authors: Enrica Golia, Giuseppe Limongelli, Francesco Natale, Fabio Fimiani, Valeria Maddaloni, Pina Elvira Russo, Lucia Riegler, Renatomaria Bianchi, Mario Crisci, Gaetano Di Palma, Paolo Golino, Maria Giovanna Russo, Raffaele Calabrò, Paolo Calabrò, Division of Cardiology, Cardio-thoracic and Respiratory Sciences Department, Second University of Naples, AO Dei Colli-Monaldi Hospital, 80131 Naples, Italy.
authors: Raffaele
authors: R
authors: Calabrò
authors: Enrica Golia, Giuseppe Limongelli, Francesco Natale, Fabio Fimiani, Valeria Maddaloni, Pina Elvira Russo, Lucia Riegler, Renatomaria Bianchi, Mario Crisci, Gaetano Di Palma, Paolo Golino, Maria Giovanna Russo, Raffaele Calabrò, Paolo Calabrò, Division of Cardiology, Cardio-thoracic and Respiratory Sciences Department, Second University of Naples, AO Dei Colli-Monaldi Hospital, 80131 Naples, Italy.
authors: Paolo
authors: P
authors: Calabrò
keywords: Adipocytokines; Coronary artery disease; Inflammation; Metabolic syndrome; Obesity