title: Violence-related PTSD and neural activation when seeing emotionally charged male-female interactions.
abstract: Post-traumatic stress disorder (PTSD) is a disorder that involves impaired regulation of the fear response to traumatic reminders. This study tested how women with male-perpetrated interpersonal violence-related PTSD (IPV-PTSD) differed in their brain activation from healthy controls (HC) when exposed to scenes of male-female interaction of differing emotional content. Sixteen women with symptoms of IPV-PTSD and 19 HC participated in this study. During magnetic resonance imaging, participants watched a stimulus protocol of 23 different 20 s silent epochs of male-female interactions taken from feature films, which were neutral, menacing or prosocial. IPV-PTSD participants compared with HC showed (i) greater dorsomedial prefrontal cortex (dmPFC) and dorsolateral prefrontal cortex (dlPFC) activation in response to menacing vs prosocial scenes and (ii) greater anterior cingulate cortex (ACC), right hippocampus activation and lower ventromedial prefrontal cortex (vmPFC) activty in response to emotional vs neutral scenes. The fact that IPV-PTSD participants compared with HC showed lower activity of the ventral ACC during emotionally charged scenes regardless of the valence of the scenes suggests that impaired social perception among IPV-PTSD patients transcends menacing contexts and generalizes to a wider variety of emotionally charged male-female interactions.
authors: Faculty of Psychology and Education, University of Geneva, Geneva, Switzerland, Child and Adolescent Psychiatry, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland, Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland, Faculty of Health, Psychology and Social Care, Manchester Metropolitan University, and Faculty of Medicine, University of Geneva, Geneva, Switzerland Faculty of Psychology and Education, University of Geneva, Geneva, Switzerland, Child and Adolescent Psychiatry, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland, Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland, Faculty of Health, Psychology and Social Care, Manchester Metropolitan University, and Faculty of Medicine, University of Geneva, Geneva, Switzerland dominik.moser@unige.ch.
authors: Dominik A
authors: DA
authors: Moser
authors: Faculty of Psychology and Education, University of Geneva, Geneva, Switzerland, Child and Adolescent Psychiatry, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland, Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland, Faculty of Health, Psychology and Social Care, Manchester Metropolitan University, and Faculty of Medicine, University of Geneva, Geneva, Switzerland.
authors: Tatjana
authors: T
authors: Aue
authors: Faculty of Psychology and Education, University of Geneva, Geneva, Switzerland, Child and Adolescent Psychiatry, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland, Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland, Faculty of Health, Psychology and Social Care, Manchester Metropolitan University, and Faculty of Medicine, University of Geneva, Geneva, Switzerland Faculty of Psychology and Education, University of Geneva, Geneva, Switzerland, Child and Adolescent Psychiatry, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland, Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland, Faculty of Health, Psychology and Social Care, Manchester Metropolitan University, and Faculty of Medicine, University of Geneva, Geneva, Switzerland.
authors: Francesca
authors: F
authors: Suardi
authors: Faculty of Psychology and Education, University of Geneva, Geneva, Switzerland, Child and Adolescent Psychiatry, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland, Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland, Faculty of Health, Psychology and Social Care, Manchester Metropolitan University, and Faculty of Medicine, University of Geneva, Geneva, Switzerland.
authors: Hana
authors: H
authors: Kutlikova
authors: Faculty of Psychology and Education, University of Geneva, Geneva, Switzerland, Child and Adolescent Psychiatry, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland, Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland, Faculty of Health, Psychology and Social Care, Manchester Metropolitan University, and Faculty of Medicine, University of Geneva, Geneva, Switzerland Faculty of Psychology and Education, University of Geneva, Geneva, Switzerland, Child and Adolescent Psychiatry, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland, Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland, Faculty of Health, Psychology and Social Care, Manchester Metropolitan University, and Faculty of Medicine, University of Geneva, Geneva, Switzerland.
authors: Maria I
authors: MI
authors: Cordero
authors: Faculty of Psychology and Education, University of Geneva, Geneva, Switzerland, Child and Adolescent Psychiatry, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland, Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland, Faculty of Health, Psychology and Social Care, Manchester Metropolitan University, and Faculty of Medicine, University of Geneva, Geneva, Switzerland.
authors: Ana Sancho
authors: AS
authors: Rossignol
authors: Faculty of Psychology and Education, University of Geneva, Geneva, Switzerland, Child and Adolescent Psychiatry, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland, Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland, Faculty of Health, Psychology and Social Care, Manchester Metropolitan University, and Faculty of Medicine, University of Geneva, Geneva, Switzerland.
authors: Nicolas
authors: N
authors: Favez
authors: Faculty of Psychology and Education, University of Geneva, Geneva, Switzerland, Child and Adolescent Psychiatry, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland, Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland, Faculty of Health, Psychology and Social Care, Manchester Metropolitan University, and Faculty of Medicine, University of Geneva, Geneva, Switzerland Faculty of Psychology and Education, University of Geneva, Geneva, Switzerland, Child and Adolescent Psychiatry, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland, Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland, Faculty of Health, Psychology and Social Care, Manchester Metropolitan University, and Faculty of Medicine, University of Geneva, Geneva, Switzerland.
authors: Sandra
authors: S
authors: Rusconi Serpa
authors: Faculty of Psychology and Education, University of Geneva, Geneva, Switzerland, Child and Adolescent Psychiatry, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland, Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland, Faculty of Health, Psychology and Social Care, Manchester Metropolitan University, and Faculty of Medicine, University of Geneva, Geneva, Switzerland Faculty of Psychology and Education, University of Geneva, Geneva, Switzerland, Child and Adolescent Psychiatry, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland, Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland, Faculty of Health, Psychology and Social Care, Manchester Metropolitan University, and Faculty of Medicine, University of Geneva, Geneva, Switzerland.
authors: Daniel S
authors: DS
authors: Schechter
mesh_terms: D000328:Adult; D017579:Domestic Violence / Q000523:psychology; D004644:Emotions / Q000502:physiology*; D005260:Female; D006624:Hippocampus / Q000503:physiopathology; D006801:Humans; D007398:Interpersonal Relations; D008279:Magnetic Resonance Imaging; D008297:Male; D009035:Mothers / Q000523:psychology; D010775:Photic Stimulation; D017397:Prefrontal Cortex / Q000503:physiopathology; D013313:Stress Disorders, Post-Traumatic / Q000523:psychology*; D014754:Violence / Q000523:psychology*; D055815:Young Adult
keywords: Parental PTSD; emotion regulation; fMRI; human interaction; interpersonal violence