title: Leukocyte adhesion deficiency type III: clinical features and treatment with stem cell transplantation.
abstract: Leukocyte adhesion deficiency type III (LADIII) is an autosomal recessive disorder that presents with a severe leukocyte adhesion defect and a Glanzmann-type thrombocytopathy. Hematopoietic stem cell transplantation (HSCT)--the only definitive treatment for LADIII--appears to have a high rate of complications. In this study, we describe a new group of patients with LADIII, highlighting further clinical and immunologic aspects of this disease, and reevaluating the effectiveness of HSCT for its treatment. The patients had clinical and laboratory findings consistent with LADIII. Molecular analysis confirmed the presence of a mutation in the kindlin-3 gene. HSCT was carried out in 3 patients and was successful in 2. The diagnosis of LADIII should be considered in all patients who present with recurrent infections and a bleeding diathesis, regardless of the leukocyte count. LADIII is a primary immune deficiency, which can be successfully corrected by bone marrow transplantation if applied early in the course of the disease using appropriate conditioning.
authors: Departments of *Pediatric Hematology-Oncology and Bone Marrow Transplantation ‡Pediatrics §Orthopedic Surgery ∥Medical Imaging, Hadassah - Hebrew University Medical Center, Jerusalem †Laboratory for Leukocyte Functions & The Pediatric Immuno-Hematology Clinic, Meir Medical Center, Kfar Saba and The Sackler School of Medicine, Tel Aviv University, Tel Aviv ¶Meyer Children's Hospital, Rambam Campus, Rappaport Faculty of Medicine, Technion, Haifa, Israel.
authors: Polina Y
authors: PY
authors: Stepensky
authors: Baruch
authors: B
authors: Wolach
authors: Ronit
authors: R
authors: Gavrieli
authors: Sharon
authors: S
authors: Rousso
authors: Tal
authors: T
authors: Ben Ami
authors: Vladimir
authors: V
authors: Goldman
authors: Katya
authors: K
authors: Rozovsky
authors: Suhair
authors: S
authors: Hanna
authors: Amos
authors: A
authors: Etzioni
authors: Michael
authors: M
authors: Weintraub
mesh_terms: D002675:Child, Preschool; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007223:Infant; D018370:Leukocyte-Adhesion Deficiency Syndrome / Q000097:blood / Q000000981:diagnostic imaging / Q000235:genetics / Q000628:therapy*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics; D009363:Neoplasm Proteins / Q000235:genetics; D009504:Neutrophils / Q000502:physiology; D011859:Radiography
chemical_list: C477322:FERMT3 protein, human; D008565:Membrane Proteins; D009363:Neoplasm Proteins