title: Incidence of hypertension, stroke, coronary heart disease, and diabetes in women who have delivered after in vitro fertilization: a population-based cohort study from Sweden.
abstract: OBJECTIVE
  To compare the incidence of hypertension, stroke, coronary heart disease, and diabetes in women who have delivered after in vitro fertilization (IVF) with those who delivered after natural conception.
  
  
  METHODS
  A cohort study in Sweden between 1990 and 2008.
  
  
  METHODS
  Sweden.
  
  
  METHODS
  23,498 women who had given birth to a child after IVF and 116,960 individually matched women.
  
  
  METHODS
  None.
  
  
  METHODS
  Incidence rates of hypertension, diabetes, stroke, and coronary heart disease in both groups.
  
  
  RESULTS
  Inpatient and outpatient diagnoses of hypertension, stroke, coronary heart disease, and diabetes were identified by linkage to the Swedish National Patient Register. The mean time of follow-up was 8.6 years in both groups. Multivariable analysis showed that hypertension had a higher incidence in IVF mothers with a hazard ratio (HR) of 1.27, 95% confidence interval (CI) 1.13-1.41, as compared with mothers from the Medical Birth Register. There was a trend to a higher incidence of stroke (HR 1.27; 95% CI, 0.96-1.68), but the incidence of coronary heart disease and diabetes did not differ.
  
  
  CONCLUSIONS
  Hypertension was more prevalent in the IVF group, which suggests that these women should be aware of their blood pressure and cardiovascular risk profile.
authors: Department of Clinical Sciences, Danderyd Hospital, Stockholm, Sweden. Electronic address: eli.westerlund@karolinska.se.
authors: Eli
authors: E
authors: Westerlund
authors: Division of Epidemiology, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden.
authors: Lena
authors: L
authors: Brandt
authors: Department of Clinical Science, Intervention and Technology, Karolinska University Hospital, Stockholm, Sweden.
authors: Outi
authors: O
authors: Hovatta
authors: Department of Clinical Sciences, Danderyd Hospital, Stockholm, Sweden.
authors: Håkan
authors: H
authors: Wallén
authors: Division of Epidemiology, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden.
authors: Anders
authors: A
authors: Ekbom
authors: Department of Clinical Sciences, Danderyd Hospital, Stockholm, Sweden.
authors: Peter
authors: P
authors: Henriksson
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003327:Coronary Disease / Q000175:diagnosis / Q000453:epidemiology*; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects*; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000453:epidemiology*; D015994:Incidence; D050498:Live Birth; D008875:Middle Aged; D015999:Multivariate Analysis; D011247:Pregnancy; D015995:Prevalence; D016016:Proportional Hazards Models; D012042:Registries; D012307:Risk Factors; D020521:Stroke / Q000175:diagnosis / Q000453:epidemiology*; D013548:Sweden / Q000453:epidemiology; D013997:Time Factors; D055815:Young Adult
keywords: Cardiovascular disease; hypertension; infertility; in vitro fertilization