title: Infliximab for treatment of granulomatous disease in patients with common variable immunodeficiency.
abstract: OBJECTIVE
  Eight to 22 % of common variable immunodeficiency (CVID) patients exhibit granulomas of the lungs, spleen, liver, and/or skin. Granulomas can be the most medically significant day-to-day problem for CVID patients. Currently, there are limited options for treatment of granulomas associated with CVID.
  
  
  METHODS
  We treated five patients with CVID who exhibited significant clinical symptoms secondary to granulomas with infliximab. The patients were selected and treated based solely on clinical need and were not otherwise controlled or blinded to the therapy. After obtaining baseline studies (labs, spirometry, radiology) and excluding infection, they were treated with infliximab 5 mg/kg at week 0, 2, 6 and every 4 weeks thereafter.
  
  
  RESULTS
  Post treatment improvements were seen in all 5 patients with significant clinical responses observed for both visceral and cutaneous granulomata. Four of the five patients were maintained on infliximab for 5 to 18 months (mean 9.4 months) without adverse reaction or increased susceptibility to infection. One patient completed 6 months of therapy with improvement of respiratory parameters but discontinued infliximab due to joint stiffness and rash that she attributed to the medication.
  
  
  CONCLUSIONS
  In our series, infliximab (5 mg/kg monthly) was an effective treatment for cutaneous and visceral granulomas in patients with CVID.
authors: Division of Allergy and Clinical Immunology, University of Michigan, Ann Arbor, MI, USA, tim.franxman@gmail.com.
authors: Timothy J
authors: TJ
authors: Franxman
authors: Laura E
authors: LE
authors: Howe
authors: James R
authors: JR
authors: Baker
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000008:administration & dosage* / Q000009:adverse effects; D017074:Common Variable Immunodeficiency / Q000150:complications / Q000188:drug therapy*; D005076:Exanthema / Q000209:etiology; D005260:Female; D006099:Granuloma / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D000069285:Infliximab; D008168:Lung / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D013147:Spirometry; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology; D055815:Young Adult
chemical_list: D000911:Antibodies, Monoclonal; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab