title: Molecular epidemiology of influenza A/H3N2 viruses circulating in Mexico from 2003 to 2012.
abstract: In this work, nineteen influenza A/H3N2 viruses isolated in Mexico between 2003 and 2012 were studied. Our findings show that different human A/H3N2 viral lineages co-circulate within a same season and can also persist locally in between different influenza seasons, increasing the chance for genetic reassortment events. A novel minor cluster was also identified, named here as Korea, that circulated worldwide during 2003. Frequently, phylogenetic characterization did not correlate with the determined antigenic identity, supporting the need for the use of molecular evolutionary tools additionally to antigenic data for the surveillance and characterization of viral diversity during each flu season. This work represents the first long-term molecular epidemiology study of influenza A/H3N2 viruses in Mexico based on the complete genomic sequences and contributes to the monitoring of evolutionary trends of A/H3N2 influenza viruses within North and Central America.
authors: Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, México.
authors: Marina
authors: M
authors: Escalera-Zamudio
authors: Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America.
authors: Martha I
authors: MI
authors: Nelson
authors: Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, México.
authors: Ana Georgina
authors: AG
authors: Cobián Güemes
authors: Instituto de Diagnóstico y Referencia Epidemiológicos, México D.F., México.
authors: Irma
authors: I
authors: López-Martínez
authors: Instituto de Diagnóstico y Referencia Epidemiológicos, México D.F., México.
authors: Natividad
authors: N
authors: Cruz-Ortiz
authors: Instituto de Diagnóstico y Referencia Epidemiológicos, México D.F., México.
authors: Miguel
authors: M
authors: Iguala-Vidales
authors: Instituto de Diagnóstico y Referencia Epidemiológicos, México D.F., México.
authors: Elvia Rodríguez
authors: ER
authors: García
authors: Instituto de Diagnóstico y Referencia Epidemiológicos, México D.F., México.
authors: Gisela
authors: G
authors: Barrera-Badillo
authors: Instituto de Diagnóstico y Referencia Epidemiológicos, México D.F., México.
authors: Jose Alberto
authors: JA
authors: Díaz-Quiñonez
authors: Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, México.
authors: Susana
authors: S
authors: López
authors: Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, México.
authors: Carlos F
authors: CF
authors: Arias
authors: Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, México.
authors: Pavel
authors: P
authors: Isa
mesh_terms: D004196:Disease Outbreaks; D016679:Genome, Viral; D006801:Humans; D053122:Influenza A Virus, H3N2 Subtype / Q000235:genetics* / Q000302:isolation & purification; D007251:Influenza, Human / Q000453:epidemiology*; D008800:Mexico; D010802:Phylogeny; D011110:Polymorphism, Genetic