title: Annulated isoxazoles via [3 + 2] cycloaddition of alkenyl bromides and oximoyl chlorides and Ag(I) promoted elimination.
abstract: Substituted salicylaldehydes are converted to fused tetracyclic isoxazoles through a synthetic sequence incorporating substitution of 2-bromo-2-cyclohexen-1-ol, formation of an oxime function, conversion to an oximoyl chloride, intramolecular [3 + 2] cycloaddition, and elimination of an equivalent of hydrogen bromide using silver(I) carbonate. Six examples of this sequence are presented.
authors: Department of Chemistry, University of British Columbia , 2036 Main Mall, Vancouver, B. C., Canada , V6T 1Z1.
authors: Emmanuel B
authors: EB
authors: Castillo-Contreras
authors: Alexander M
authors: AM
authors: Stahl
authors: Gregory R
authors: GR
authors: Dake