title: The stereoselective synthesis of α-amino aldols starting from terminal alkynes.
abstract: A new procedure for the stereoselective synthesis of syn α-amino β-oxy ketones is reported. It consists of two steps; in the first step, α-amino silyl enol ethers having a (Z) geometry are prepared from 1-alkynes via 1-sulfonyl-1,2,3-triazoles. In the second step, the silyl enol ethers undergo the TiCl4-mediated Mukaiyama aldol reaction with aldehydes to produce α-amino β-oxy ketones with excellent syn-selectivity.
authors: Department of Synthetic Chemistry and Biological Chemistry, Kyoto University, Katsura, Kyoto 615-8510, Japan. tmiura@sbchem.kyoto-u.ac.jp murakami@sbchem.kyoto-u.ac.jp.
authors: Tomoya
authors: T
authors: Miura
authors: Takayuki
authors: T
authors: Nakamuro
authors: Kentaro
authors: K
authors: Hiraga
authors: Masahiro
authors: M
authors: Murakami