title: No evidence of programmed late-life mortality in the Finnish famine cohort.
abstract: The developmental origins hypothesis suggests that morbidity and premature mortality arise, in part, from adverse exposures in utero and early in development. Evidence suggests a connection between early nutritional deficits and adult morbidity; however, the effects on mortality have been less well studied and previous studies provide conflicting results. We extracted Finnish birth cohort death rates from the Human Mortality Database. Our test asks whether men or women born during the 1867-1868 Great Finnish Famine exhibited death rates in old age different from expected, based on death rates among Finnish cohorts born 1818-1866. We found no support for the argument that exposure to the Finnish famine in utero induced excess mortality from age 60 to 89 in either men or women. Our results suggest that the Finnish famine did not induce, via epigenetic changes or any other mechanism, premature mortality in older age among exposed individuals.
authors: 1 Department of Biology, Santa Clara University, Santa Clara, CA, USA.
authors: K
authors: K
authors: Saxton
authors: 2 School of Public Health, University of California, Berkeley, CA, USA.
authors: A
authors: A
authors: Falconi
authors: 2 School of Public Health, University of California, Berkeley, CA, USA.
authors: S
authors: S
authors: Goldman-Mellor
authors: 2 School of Public Health, University of California, Berkeley, CA, USA.
authors: R
authors: R
authors: Catalano
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005260:Female; D005387:Finland / Q000453:epidemiology; D049672:History, 19th Century; D006801:Humans; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D009026:Mortality / Q000266:history*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology*; D013217:Starvation / Q000150:complications* / Q000453:epidemiology* / Q000266:history