title: Initial experience of correlating parameters of intravoxel incoherent motion and dynamic contrast-enhanced magnetic resonance imaging at 3.0 T in nasopharyngeal carcinoma.
abstract: OBJECTIVE
  To determine the correlation between intravoxel incoherent motion (IVIM) and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) parameters.
  
  
  METHODS
  Thirty-eight newly diagnosed NPC patients were prospectively enrolled. Diffusion-weighted images (DWI) at 13 b-values were acquired using a 3.0-T MRI system. IVIM parameters including the pure molecular diffusion (D), perfusion-related diffusion (D*), perfusion fraction (f), DCE-MRI parameters including maximum slope of increase (MSI), enhancement amplitude (EA) and enhancement ratio (ER) were calculated by two investigators independently. Intra- and interobserver agreement were evaluated using the intraclass correlation coefficient (ICC) and Bland-Altman analysis. Relationships between IVIM and DCE-MRI parameters were evaluated by calculation of Spearman's correlation coefficient.
  
  
  RESULTS
  Intra- and interobserver reproducibility were excellent to relatively good (ICC = 0.887-0.997; narrow width of 95 % limits of agreement). The highest correlation was observed between f and EA (r = 0.633, P < 0.001), with a strong correlation between f and MSI (r = 0.598, P = 0.001). No correlation was observed between f and ER (r = -0.162; P = 0.421) or D* and DCE parameters (r = 0.125-0.307; P > 0.119).
  
  
  CONCLUSIONS
  This study suggests IVIM perfusion imaging using 3.0-T MRI is feasible in NPC, and f correlates significantly with EA and MSI.
  
  
  CONCLUSIONS
  Assessment of tumour perfusion is important in nasopharyngeal carcinoma. DCE-MRI provided perfusion information with the use of intravenous contrast media. Perfusion information could be provided by non-invasive IVIM MRI. IVIM parameter f correlated with DCE-MRI parameters.
authors: Department of Radiology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, 106 Zhong Shan Er Road, Guangzhou, Guangdong Province, 510080, People's Republic of China, jiaqianjun@126.com.
authors: Qian-Jun
authors: QJ
authors: Jia
authors: Shui-Xing
authors: SX
authors: Zhang
authors: Wen-Bo
authors: WB
authors: Chen
authors: Long
authors: L
authors: Liang
authors: Zheng-Gen
authors: ZG
authors: Zhou
authors: Qian-Hui
authors: QH
authors: Qiu
authors: Zai-Yi
authors: ZY
authors: Liu
authors: Qiong-Xin
authors: QX
authors: Zeng
authors: Chang-Hong
authors: CH
authors: Liang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma; D003287:Contrast Media; D004058:Diffusion; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009038:Motion; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis*; D015588:Observer Variation; D011446:Prospective Studies; D015203:Reproducibility of Results
chemical_list: D003287:Contrast Media