title: The prevalence and distribution of Th17 and Tc17 cells in patients with thyroid tumor.
abstract: Both Th17 and Tc17 cells have been found in various tumors and may play important roles in regulating anti-tumor immune responses. However, the prevalence and distribution of Th17 and Tc17 cells in thyroid tumors are still unclear. In the current study, we examined the percentages of Th17 and Tc17 cells in the peripheral blood of 31 thyroid adenoma and 11 thyroid carcinoma patients. The serum IL-17 levels were also examined and their associations with Th17 and Tc17 cells were evaluated. Moreover, the presence of Th17 cells was detected in both thyroid adenoma and carcinoma patients. Our results showed that compared with healthy individuals, patients with thyroid tumors had a higher proportion of Th17 and lower proportion of Tc17 cells in peripheral blood. The serum concentration of IL-17 was significantly increased in patients with thyroid tumors and it was correlated with the percent of Th17 cells. Furthermore, the number of Th17 cells was significantly increased in the tumors of the patients. Th17 and Tc17 cells were negatively correlated with the tumor size. There was no significant difference between thyroid adenoma and carcinoma patients. These results indicate that Th17 cells may contribute to thyroid tumor pathogenesis.
authors: Department of General Surgery, Second Affiliated Hospital of Soochow University, Suzhou 215004, PR China.
authors: Guoqin
authors: G
authors: Jiang
authors: Laboratory of Cellular and Molecular Tumor Immunology, Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, 215123, PR China.
authors: Shoubao
authors: S
authors: Ma
authors: Department of General Surgery, Second Affiliated Hospital of Soochow University, Suzhou 215004, PR China.
authors: Yan
authors: Y
authors: Wei
authors: Laboratory of Cellular and Molecular Tumor Immunology, Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, 215123, PR China.
authors: Yan
authors: Y
authors: Wu
authors: Laboratory of Cellular and Molecular Tumor Immunology, Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, 215123, PR China.
authors: Xiao
authors: X
authors: Yu
authors: Laboratory of Cellular and Molecular Tumor Immunology, Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, 215123, PR China; Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou 215006, PR China. Electronic address: hliu@suda.edu.cn.
authors: Haiyan
authors: H
authors: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D020381:Interleukin-17 / Q000097:blood; D018655:Lymphocyte Count; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000378:metabolism; D018417:Th1 Cells / Q000276:immunology / Q000378:metabolism; D058504:Th17 Cells / Q000276:immunology* / Q000378:metabolism; D013964:Thyroid Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D055815:Young Adult
chemical_list: D020381:Interleukin-17
keywords: IL-17; Tc17 cells; Th17 cells; Thyroid tumor