title: [Pathological study of cerebral amyloid angiopathy in rat models of Alzheimer's disease].
abstract: OBJECTIVE
  To examine cerebral pathologies in cerebral amyloid angiopathy in a rat model of Alzheimer's disease.
  
  
  METHODS
  Rat models of Alzheimer's disease was established by stereotactic Aβ1-42 fiber injection in the bilateral hippocampus. The cognitive function of the rats was evaluated with water maze test. HE staining, Congo red staining and double-labeling indirect immunofluorescence were used to examine the dynamic distribution of Aβ fiber deposit in the brain.
  
  
  RESULTS
  The model rats showed significant differences from the control rats in the escape latency and the times of crossing platform in waster maze test. HE staining revealed a decreased number and degeneration of the granular cells with increased glial cells in the model rats. Congo Red staining showed that the Aβ fiber was deposited gradually in the small vessels in the brain parenchyma to cause thickening, stenosis or occlusion of the small vessels. Immunofluorescence staining detected Aβ fiber migration from the parenchyma to the walls of the small arteries in the rat models.
  
  
  CONCLUSIONS
  Cerebral amyloid angiopathy is a major pathological feature in Alzheimer's disease.
authors: Department of Neurology, Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China. E-mail: lutianming@139.com.
authors: Tianming
authors: T
authors: Lv
authors: Yanshan
authors: Y
authors: Liang
authors: Cuili
authors: C
authors: Shi
authors: Xiaoyu
authors: X
authors: Huang
authors: Zhiyong
authors: Z
authors: Pan
authors: Rong
authors: R
authors: Ling
authors: Wenling
authors: W
authors: Zhang
authors: Mengxi
authors: M
authors: Hao
authors: Qiuyao
authors: Q
authors: Guo
authors: Yu
authors: Y
authors: Zeng
authors: Jia
authors: J
authors: Yin
mesh_terms: D000544:Alzheimer Disease / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000737:chemistry*; D000818:Animals; D001921:Brain / Q000473:pathology; D016657:Cerebral Amyloid Angiopathy / Q000473:pathology*; D004195:Disease Models, Animal; D051381:Rats; D013194:Staining and Labeling
chemical_list: D016229:Amyloid beta-Peptides