title: Endocrine disruptors and other inhibitors of 11β-hydroxysteroid dehydrogenase 1 and 2: Tissue-specific consequences of enzyme inhibition.
abstract: Numerous chemicals in the environment have the ability to interact with the endocrine system. These compounds are called endocrine disruptors (EDs). Exposure to EDs represents one of the hypotheses for decreasing fertility, the increased risk of numerous cancers and obesity, metabolic syndrome and type 2 diabetes. There are various mechanisms of ED action, one of which is their interference in the action of 11β-hydroxysteroid dehydrogenase (11βHSD) that maintains a balance between active and inactive glucocorticoids on the intracellular level. This enzyme has two isoforms and is expressed in various tissues. Inhibition of 11βHSD in various tissues can have different consequences. In the case of EDs, the results of exposure are mainly adverse; on the other hand pharmaceutically developed inhibitors of 11βHSD type 1 are evaluated as an option for treating metabolic syndrome, as well as related diseases and depressive disorders. This review focuses on the effects of 11βHSD inhibitors in the testis, colon, adipose tissue, kidney, brain and placenta.
authors: Institute of Endocrinology, Department of Steroids and Proteofactors, Prague, Czech Republic. Electronic address: jkubatova@endo.cz.
authors: Jana
authors: J
authors: Vitku
authors: Institute of Endocrinology, Department of Steroids and Proteofactors, Prague, Czech Republic.
authors: Luboslav
authors: L
authors: Starka
authors: Institute of Endocrinology, Department of Steroids and Proteofactors, Prague, Czech Republic.
authors: Marie
authors: M
authors: Bicikova
authors: Institute of Endocrinology, Department of Steroids and Proteofactors, Prague, Czech Republic.
authors: Martin
authors: M
authors: Hill
authors: Charles University, Third Faculty of Medicine, Department of Urology, Prague, Czech Republic; Faculty Hospital Kralovske Vinohrady, Department of Urology, Prague, Czech Republic.
authors: Jiri
authors: J
authors: Heracek
authors: Institute of Endocrinology, Department of Steroids and Proteofactors, Prague, Czech Republic.
authors: Lucie
authors: L
authors: Sosvorova
authors: Institute of Endocrinology, Department of Steroids and Proteofactors, Prague, Czech Republic.
authors: Richard
authors: R
authors: Hampl
mesh_terms: D043205:11-beta-Hydroxysteroid Dehydrogenase Type 1 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D043209:11-beta-Hydroxysteroid Dehydrogenase Type 2 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000273:Adipose Tissue / Q000187:drug effects / Q000201:enzymology; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D003106:Colon / Q000187:drug effects / Q000201:enzymology; D003920:Diabetes Mellitus / Q000139:chemically induced / Q000201:enzymology / Q000473:pathology; D052244:Endocrine Disruptors / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005260:Female; D005938:Glucocorticoids / Q000378:metabolism; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000139:chemically induced / Q000201:enzymology / Q000473:pathology; D009369:Neoplasms / Q000139:chemically induced / Q000201:enzymology / Q000473:pathology; D009765:Obesity / Q000139:chemically induced / Q000201:enzymology / Q000473:pathology; D009928:Organ Specificity; D010920:Placenta / Q000187:drug effects / Q000201:enzymology; D011247:Pregnancy; D013737:Testis / Q000187:drug effects / Q000201:enzymology
chemical_list: D052244:Endocrine Disruptors; D004791:Enzyme Inhibitors; D005938:Glucocorticoids; D043205:11-beta-Hydroxysteroid Dehydrogenase Type 1; D043209:11-beta-Hydroxysteroid Dehydrogenase Type 2
keywords: 11β-hydroxysteroid dehydrogenase; Adipose tissue; Brain; Colon; Endocrine disruptor; Inhibitor; Placenta; Testis