title: In vitro cytotoxicity of some Narcissus plants extracts.
abstract: This study compares the chloroform extracts of bulbs and roots of Narcissus papyraceus Ker Gawl. and Narcissus tazetta L. The cytotoxicity of the plant extracts was evaluated against human hepatocellular carcinoma cell line (HEPG2) and colon carcinoma cell line (HCT116) in comparison to doxorubicin. The extracts from the after-flowering (AF) bulbs of N. tazetta L. and N. papyraceus exhibited strong cytotoxic activity against HEPG2 (IC50: 2.2, 3.5 μg mL(-1)) and HCT116 (IC50: 4.2, 3.9 μg mL(-1)) cell lines, respectively. N. tazetta L. bulbs exhibited the least cell viability percentage in HepG-2 cell line (5.32%), while the AF root extracts of N. papyraceus exhibited the least cell viability percentage in HCT116 cell line (4.93%), when applied at a concentration of 50 μg mL(-1), thereby being more active than doxorubicin at the same concentration.
authors: a Department of Pharmacognosy , Faculty of Pharmacy, University of Alexandria , Alkhartoom Square, Alexandria 21521 , Egypt.
authors: Eman
authors: E
authors: Shawky
authors: Amina H
authors: AH
authors: Abou-Donia
authors: Fikria A
authors: FA
authors: Darwish
authors: Soad M
authors: SM
authors: Toaima
authors: Sarah S
authors: SS
authors: Takla
authors: Mahmoud Mohamed
authors: MM
authors: Al Asaar
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D045325:HCT116 Cells; D056945:Hep G2 Cells; D006801:Humans; D031427:Narcissus / Q000737:chemistry* / Q000145:classification; D010936:Plant Extracts / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts
keywords: Amaryllidaceae; HCT116; HEPG2; Narcissus papyraceus Ker Gawl.; Narcissus tazetta L.; cytotoxic