title: Utility of a monitoring strategy for human herpesviruses 6 and 7 viremia after liver transplantation: a randomized clinical trial.
abstract: BACKGROUND
  Reactivation of human herpesvirus (HHV)-6 and HHV-7 has been linked to various posttransplant adverse events through immunomodulatory effects. The potential utility of monitoring for HHV-6 and HHV-7 viremia remains unclear.
  
  
  METHODS
  In this clinical trial, 129 liver transplant recipients were randomized to be monitored in real-time for HHV-6 and HHV-7 viremia by polymerase chain reaction at regular intervals from 0 to 12 weeks after transplantation ("monitoring" group) or to undergo usual care ("no-monitoring" group). Therapeutic intervention for a positive polymerase chain reaction result included reduction in immunosuppression and preemptive antiviral therapy, at the discretion of the attending team. The primary outcome was a composite of adverse events indirectly attributable to viral reactivation (including opportunistic infection, graft rejection and severe hepatitis C virus recurrence).
  
  
  RESULTS
  In the "monitoring" group, HHV-6 and HHV-7 viremia occurred in 23 of 64 patients (35.9%) and 21 of 64 patients (32.8%) patients, respectively. We found no cases of symptomatic HHV-6 and HHV-7 disease. Some therapeutic interventions were performed in 59.1% of viremic episodes. There were no differences in cumulative incidence of the primary outcome between the "monitoring" and "no-monitoring" groups at 1 year (58.7% vs. 52.3%; odds ratio, 0.77; 95% confidence interval, 0.38-1.55) or at 5 years after transplantation (79.0% vs. 70.3%; odds ratio, 0.63; 95% confidence interval, 0.28-1.42). However, we found a trend toward a lower incidence of graft rejection at year 1 in the "monitoring" group (30.2% vs. 44.6%; P=0.091).
  
  
  CONCLUSIONS
  In this first trial, no benefit could be demonstrated from routine monitoring of HHV-6 and HHV-7 viremia in graft or patient outcome after liver transplantation.
authors: 1 Multi-Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada. 2 Department of Microbiology, Mount Sinai Hospital, Toronto, Ontario, Canada.
authors: Mario
authors: M
authors: Fernández-Ruiz
authors: Deepali
authors: D
authors: Kumar
authors: Shahid
authors: S
authors: Husain
authors: Les
authors: L
authors: Lilly
authors: Eberhard
authors: E
authors: Renner
authors: Tony
authors: T
authors: Mazzulli
authors: George
authors: G
authors: Moussa
authors: Atul
authors: A
authors: Humar
mesh_terms: D000328:Adult; D005260:Female; D015654:Herpesvirus 6, Human / Q000235:genetics*; D016199:Herpesvirus 7, Human / Q000235:genetics*; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D009864:Ontario; D009894:Opportunistic Infections / Q000175:diagnosis* / Q000628:therapy / Q000821:virology; D011237:Predictive Value of Tests; D060888:Real-Time Polymerase Chain Reaction; D019349:Roseolovirus Infections / Q000175:diagnosis* / Q000628:therapy / Q000821:virology; D013997:Time Factors; D019562:Viral Load; D014766:Viremia / Q000175:diagnosis* / Q000628:therapy / Q000821:virology