title: New perspectives on using brain imaging to study CNS stimulants.
abstract: While the recent application of brain imaging to study CNS stimulants has offered new insights into the fundamental factors that contribute to their use and abuse, many gaps remain. Brain circuits that mediate pleasure, dependence, craving and relapse are anatomically, neurophysiologically and neurochemically distinct from one another, which has guided the search for correlates of stimulant-seeking and taking behavior. However, unlike other drugs of abuse, metrics for tolerance and physical dependence on stimulants are not obvious. The dopamine theory of stimulant abuse does not sufficiently explain this disorder as serotonergic, GABAergic and glutamagergic circuits are clearly involved in stimulant pharmacology and so tracking the source of the "addictive" processes must adopt a more multimodal, multidisciplinary approach. To this end, both anatomical and functional magnetic resonance imaging (MRI), MR spectroscopy (MRS) and positron emission tomography (PET) are complementary and have equally contributed to our understanding of how stimulants affect the brain and behavior. New vistas in this area include nanotechnology approaches to deliver small molecules to receptors and use MRI to resolve receptor dynamics. Anatomical and blood flow imaging has yielded data showing that cognitive enhancers might be useful adjuncts in treating CNS stimulant dependence, while MRS has opened opportunities to examine the brain's readiness to accept treatment as GABA tone normalizes after detoxification. A desired outcome of the above approaches is being able to offer evidence-based rationales for treatment approaches that can be implemented in a more broad geographic area, where access to brain imaging facilities may be limited. This article is part of the Special Issue entitled 'CNS Stimulants'.
authors: McLean Imaging Center, McLean Hospital, NIC Mail Stop 319, 115 Mill St., Belmont, MA 02478, USA; Behavioral Psychopharmacology Research Laboratory, McLean Hospital, NIC Mail Stop 319, 115 Mill St., Belmont, MA 02478, USA; Harvard Medical School, USA. Electronic address: Lukas@mcLean.harvard.edu.
authors: Scott E
authors: SE
authors: Lukas
mesh_terms: D001921:Brain / Q000033:anatomy & histology / Q000187:drug effects* / Q000502:physiology; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D006801:Humans; D059906:Neuroimaging / Q000379:methods*
chemical_list: D000697:Central Nervous System Stimulants
keywords: Cocaine; Electroencephalography; Magnetic resonance imaging; Methamphetamine; Positron emission tomography; Stimulants