title: Protective effects of growth hormone on bacterial translocation and intestinal damage in rats with partial intestinal obstruction.
abstract: OBJECTIVE
  One of the reasons of bacterial translocation (BT) is the complete or partial intestinal obstructions (PIO) of the gastrointestinal system. In this study, we aimed to investigate the effects of recombinant human Growth Hormone (rhGH) on BT in rats with partial intestinal obstruction (PIO).
  
  
  METHODS
  The rats were randomly divided into the 4 groups: Group I: Sham-operated (SO) (n = 12), Group II control PIO (n = 12), Group III: PIO with rhGH treatment for 5 days (n = 12), Group IV: PIO with rhGH treatment 5 days before PIO and 5 days after PIO (a total of 10 days) (n = 12). In the groups III and IV, the effects of 5 and 10 days administered rhGH were examined.
  
  
  RESULTS
  The level of serum and of intestinal fluid IgA was significantly higher in the Group IV compared to the Group I, Group II and Group III. In the Group IV, the number of small intestinal goblet and colonic goblet cells, and the lengths of intestinal mucosal villi and crypt depths were statistically significantly higher than in Groups II and III. The rate of bacterial translocation was higher in the Group II: 100 % in MLNs, 41.6 % in blood culture and 50.8 % in the liver cultures, it was significantly higher compared to the other groups (p < 0.01).
  
  
  CONCLUSIONS
  The study results demonstrated that administration of rhGH to the rats with PIO for at least 10 days decreased bacterial translocation (Fig. 3, Ref. 25).
authors: A
authors: A
authors: Kaymakci
authors: S
authors: S
authors: Guven
authors: I
authors: I
authors: Ciftci
authors: I
authors: I
authors: Akillioglu
authors: M
authors: M
authors: Aktan
authors: H H
authors: HH
authors: Eker
authors: A
authors: A
authors: Sutcu
authors: A
authors: A
authors: Abasiyanik
mesh_terms: D000328:Adult; D000818:Animals; D018988:Bacterial Translocation / Q000187:drug effects*; D019382:Human Growth Hormone / Q000494:pharmacology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D007413:Intestinal Mucosa / Q000382:microbiology / Q000473:pathology; D007415:Intestinal Obstruction / Q000097:blood* / Q000188:drug therapy* / Q000382:microbiology; D008099:Liver / Q000382:microbiology; D008297:Male; D020011:Protective Agents / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D011994:Recombinant Proteins / Q000494:pharmacology
chemical_list: D007070:Immunoglobulin A; D020011:Protective Agents; D011994:Recombinant Proteins; D019382:Human Growth Hormone