title: Polyphenols with anti-proliferative activities from Penthorum chinense Pursh.
abstract: Two new polyphenols, penthorumin C (1) and 2,6-dihydroxyacetophenone-4-O- [4',6'-(S)-hexahydroxydiphenoyl]-β-D-glucose (2), along with four known polyphenolic acids, pinocembrin-7-O-[4",6"-hexahydroxydiphenoyl]-β-D-glucose(3), pinocembrin-7-O-[3"-O- galloyl- 4",6"-hexahydroxydiphenoyl]-β-D-glucose (4), thonningianin A (5), and thonningianin B (6) were isolated from Penthourm chinense. All compounds were evaluated for their anti-proliferative activity in HSC-T6 cells, and 2 and 5 showed significant activity, with IC50 values of 12.7 and 19.2 μM, respectively.
authors: Department of Identification of Traditional Chinese Medicine, School of Pharmacy, Second Military Medical University, Shanghai 200433, China. hdd890920@163.com.
authors: Doudou
authors: D
authors: Huang
authors: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Science, University of Macau, Macau, China. jiangyun@163.com.
authors: Yun
authors: Y
authors: Jiang
authors: Department of Pharmacy, Changzheng Hospital, Shanghai 200003, China. chenws126@126.com.
authors: Wansheng
authors: W
authors: Chen
authors: Department of Identification of Traditional Chinese Medicine, School of Pharmacy, Second Military Medical University, Shanghai 200433, China. yaofy2013@163.com.
authors: Fengyan
authors: F
authors: Yao
authors: Department of Identification of Traditional Chinese Medicine, School of Pharmacy, Second Military Medical University, Shanghai 200433, China. lnsun@smmu.edu.cn.
authors: Lianna
authors: L
authors: Sun
mesh_terms: D000818:Animals; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival; D004305:Dose-Response Relationship, Drug; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D059808:Polyphenols / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D064028:Tracheophyta / Q000737:chemistry*
chemical_list: D010936:Plant Extracts; D059808:Polyphenols