title: Orthogonal control of antibacterial activity with light.
abstract: Selection of a single bacterial strain out of a mixture of microorganisms is of crucial importance in healthcare and microbiology research. Novel approaches that can externally control bacterial selection are a valuable addition to the microbiology toolbox. In this proof-of-concept, two complementary antibiotics are protected with photocleavable groups that can be orthogonally addressed with different wavelengths of light. This allows for the light-triggered selection of a single bacterial strain out of a mixture of multiple strains, by choosing the right wavelength. Further improvement toward additional orthogonally addressable antibiotics might ultimately lead to a novel methodology for bacterial selection in complex populations.
authors: Centre for Systems Chemistry, Stratingh Institute for Chemistry and §Zernike Institute for Advanced Materials, University of Groningen , Nijenborgh 4, 9747 AG Groningen, The Netherlands.
authors: Willem A
authors: WA
authors: Velema
authors: Jan Pieter
authors: JP
authors: van der Berg
authors: Wiktor
authors: W
authors: Szymanski
authors: Arnold J M
authors: AJ
authors: Driessen
authors: Ben L
authors: BL
authors: Feringa
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001431:Bacteriological Techniques / Q000379:methods*; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development; D024841:Fluoroquinolones / Q000494:pharmacology; D008027:Light; D010400:Penicillin G / Q000494:pharmacology; D055668:Photochemical Processes; D013056:Spectrophotometry, Ultraviolet; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D010400:Penicillin G