title: No association between wolframin gene H611R polymorphism and mood disorders: evidence from 2,570 subjects.
abstract: BACKGROUND
  In the past few decades, a number of studies have investigated the association of the wolframin (WFS1) gene H611R polymorphism with mood disorders, but the findings are not always consistent.
  
  
  OBJECTIVE
  The objective of the present study is to assess the association between WFS1 gene H611R polymorphism and mood disorders by using a meta-analysis.
  
  
  METHODS
  A comprehensive literature search of PubMed, Excerpta Medica Database, Elsevier Science Direct and China National Knowledge Infrastructure databases was conducted to identify relevant articles, with the last report up to April 15, 2014. Pooled odds ratio (OR) with 95% confidence interval (CI) was estimated.
  
  
  RESULTS
  Seven studies including 1318 cases and 1252 controls were selected from potentially relevant articles. This meta-analysis showed that there was no significant association between WFS1 gene H611R polymorphism and mood disorders (R vs. H: OR = 0.93, 95% CI = 0.82-1.05, P = 0.22; HR+ RR vs. HH: OR = 0.98, 95% CI = 0.82-1.17, P = 0.80; RR vs. HH+ HR: OR = 0.84, 95% CI = 0.67-1.04, P = 0.11; RR vs. HH: OR = 0.86, 95% CI = 0.67-1.10, P = 0.24; HR vs. HH: OR = 1.03, 95% CI = 0.78-1.36, P = 0.83). In subgroup analyses by ethnicity, we did not detect any significant association of this polymorphism with mood disorders in Caucasian and Asian populations (P > 0.05). In subgroup analyses by types of mood disorders, we also did not detect any significant association of this polymorphism with bipolar disorder or major depressive disorder (P > 0.05).
  
  
  CONCLUSIONS
  The results of this meta-analysis suggest that there is no association between WFS1 gene H611R polymorphism and mood disorders.
authors: Xiao-Wu Tang, Department of Medicine, HeFei Vocational and Technical College , ChaoHu 238000, Anhui , China.
authors: Xiao-Wu
authors: XW
authors: Tang
authors: Juan
authors: J
authors: Wang
authors: Yan-Feng
authors: YF
authors: Zou
mesh_terms: D044466:Asian People / Q000235:genetics; D001714:Bipolar Disorder / Q000235:genetics; D003865:Major Depressive Disorder / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D019964:Mood Disorders / Q000208:ethnology / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D017594:Publication Bias; D044465:White People / Q000235:genetics
chemical_list: D008565:Membrane Proteins; C114987:wolframin protein
keywords: Meta-analysis; Mood disorders; Polymorphism; WFS1