title: Pituitary dysfunction in granulomatosis with polyangiitis: the Mayo Clinic experience.
abstract: BACKGROUND
  Pituitary involvement in granulomatosis with polyangiitis (GPA) has been described in case reports. The aim of this study was to describe the clinical presentation and outcomes of pituitary disease in patients with GPA evaluated at a tertiary referral center.
  
  
  METHODS
  A retrospective review of patients with GPA-related pituitary disease seen at the Mayo Clinic in Rochester, Minnesota.
  
  
  METHODS
  A total of 637 patients with antineutrophil cytoplasmic antibodies-associated vasculitis were followed at our institution from 1996 through 2011. Eight patients (1.3%) with clinically confirmed pituitary involvement formed the basis of this study.
  
  
  METHODS
  None.
  
  
  METHODS
  Pituitary function was assessed with hormonal testing, including TSH, free T4, cortisol, ACTH, prolactin, FSH, LH, estradiol, T, IGF-1, and simultaneous serum and urine osmolalities.
  
  
  RESULTS
  Secondary hypogonadism and diabetes insipidus were the predominant manifestations of pituitary disease (87.5 and 75% of patients, respectively). All patients had abnormal pituitary imaging. A sellar mass with central cystic change and peripheral enhancement was the commonest imaging finding. Pituitary disease was managed with glucocorticoids in combination with cyclophosphamide or rituximab, achieving disease remission in all but one patient. However, permanent anterior pituitary dysfunction was noted in 63% of the patients. Diabetes insipidus was more often reversible, with resolution in 66.7% of the patients.
  
  
  CONCLUSIONS
  Pituitary involvement in GPA is rare, but it needs to be recognized to avoid unnecessary biopsies of sellar lesions encountered in the context of GPA, and to minimize the risk of irreversible pituitary function loss by prompt implementation of definitive medical therapy for the vasculitis.
authors: Divisions of General Internal Medicine (E.K.), Pulmonary and Critical Care Medicine (R.C.-C., U.S.) Ophthalmology (J.L.), Radiology (B.E.), and Endocrinology (D.E.), Mayo Clinic, Rochester, Minnesota 55905.
authors: Ekta
authors: E
authors: Kapoor
authors: Rodrigo
authors: R
authors: Cartin-Ceba
authors: Ulrich
authors: U
authors: Specks
authors: Jacqueline
authors: J
authors: Leavitt
authors: Bradley
authors: B
authors: Erickson
authors: Dana
authors: D
authors: Erickson
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010900:Pituitary Diseases / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D010901:Pituitary Function Tests; D010902:Pituitary Gland / Q000473:pathology / Q000503:physiopathology*; D012189:Retrospective Studies