title: The safety of propofol infusion compared to midazolam and meperidine intravenous bolus for patients undergoing double balloon enteroscopy.
abstract: OBJECTIVE
  The double balloon enteroscopy (DBE) procedure is long and requires moderate sedation. We aim to determine whether the administration of propofol infusion is safe by comparing it to intravenous midazolam/meperidine in patients undergoing DBE.
  
  
  METHODS
  A prospective study with 48 patients was conducted at King Chulalongkorn Hospital randomizing (block of four) patients into two groups. In group 1, 28 patients were enrolled for intravenous midazolam/meperidine, and one patient was dropped out before underwent DBE due to hemodynamic instability. Therefore, 27 (n = 27) participants were included in Group 1. In group 2, 28 patients were enrolled for propofol infusion, and seven patients were dropped out before underwent DBE, five due to hemodynamic instability (n = 5), and two refused treatment (n = 2). Therefore, 1 (n = 21) participants were included in Group 2. Vital signs and oxygen saturation were regularly monitored.
  
  
  RESULTS
  Mean +/- SD age of patients was 56.8 +/- 9.2 years, and 41.7% of patients were male. There was no difference in demographic data between the groups. For the safety profile, 25.9% of the midazolam/meperidine group and 33.3% of the propofol group developed hypotension and/or desaturation (p = 0.45). The patients' satisfaction of group 1 and group 2 were 86.7 +/- 6.5% and 86.3 +/- 8.1%, respectively, and presented no significant difference (p = 0.89).
  
  
  CONCLUSIONS
  Propofol infusion is safe and shows no difference in outcome from the midazolam and meperidine sedation for the DBE procedure.
authors: Sombat
authors: S
authors: Treeprasertsuk
authors: Rungsun
authors: R
authors: Rerknimitr
authors: Phonthep
authors: P
authors: Angsuwatcharakon
authors: Wiriyaporn
authors: W
authors: Ridtitid
authors: Kessarin
authors: K
authors: Thanapirom
authors: Pradermchai
authors: P
authors: Kongkam
authors: Yuwadee
authors: Y
authors: Ponuthai
authors: Vichai
authors: V
authors: Viriyautsahakul
mesh_terms: D000759:Adjuvants, Anesthesia / Q000008:administration & dosage* / Q000009:adverse effects; D016292:Procedural Sedation / Q000379:methods*; D058582:Double-Balloon Enteroscopy; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage* / Q000009:adverse effects; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D008297:Male; D008614:Meperidine / Q000008:administration & dosage*; D008874:Midazolam / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D061214:Patient Safety; D017060:Patient Satisfaction; D015742:Propofol / Q000008:administration & dosage* / Q000009:adverse effects; D011446:Prospective Studies
chemical_list: D000759:Adjuvants, Anesthesia; D006993:Hypnotics and Sedatives; D008614:Meperidine; D008874:Midazolam; D015742:Propofol