title: Expeditious metal-free access to functionalized polycyclic acetals under mild aqueous conditions.
abstract: A facile approach for the synthesis of furopyrans and bicyclic bisacetals under mild aqueous conditions is described. This potentially green, diversity oriented approach involves cascade Michael addition and cycloacetalization of pyranones and 1,3-dicarbonyls. An interesting switch in the product class was observed depending on the type of pyranone employed. Products of type I and II obtained herein are an integral part of several bioactive natural products and medicinally interesting compounds.
authors: Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali , Sector 81, S. A. S. Nagar, Manuali PO, Punjab 140306, India.
authors: Sanghratna
authors: S
authors: Kasare
authors: Siddheshwar K
authors: SK
authors: Bankar
authors: S S V
authors: SS
authors: Ramasastry
mesh_terms: D000080:Acetals / Q000138:chemical synthesis* / Q000737:chemistry; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D015394:Molecular Structure; D014867:Water / Q000737:chemistry
chemical_list: D000080:Acetals; D001688:Biological Products; D014867:Water