title: Changes in hormones and biomarkers in polycystic ovarian syndrome treated with gastric bypass.
abstract: BACKGROUND
  Small retrospective studies have demonstrated reduction in weight and co-morbid hirsutism and diabetes in women with polycystic ovary syndrome (PCOS) treated with Roux-en-Y gastric bypass. The objective of this study was to prospectively determine clinical improvements in obese women with PCOS treated with gastric bypass and identify postoperative biomarker changes.
  
  
  METHODS
  Data were collected on obese women with PCOS undergoing Roux-en-Y gastric bypass over 1 year. Testosterone, follicle stimulating hormone, lutenizing hormone, insulin, fasting glucose, and lipid levels were obtained preoperatively at baseline, and 6 and 12 months after surgery. Testosterone was used as the primary hormonal biomarker. A physical examination for body mass index (BMI) and hirsutism, and information on menstrual pattern were collected at baseline and 3, 6, and 12 months after surgery.
  
  
  RESULTS
  Data were available for 14 women. Mean BMI decreased from 44.8±5.9 kg/m(2) at baseline to 29.2±5.9 kg/m(2) at 12 months postoperatively. Significant improvements were seen in testosterone, fasting glucose, insulin, cholesterol, and triglyceride at 12 months (P<.05). At baseline, irregular menses were reported in 10 patients; all patients were experiencing regular menses 6 and 12 months after surgery. Hirsutism was present in 11 patients at baseline and only 7 patients at 12 months. Improvements in biomarkers, menstrual cycling, and hirsutism was not correlated with degree of weight change.
  
  
  CONCLUSIONS
  Gastric bypass achieved significant reductions in BMI, testosterone, and markers of glucose and lipid metabolism. These data confirm reports of previous retrospective studies showing weight reduction and health improvement in women with PCOS treated with gastric bypass.
authors: Department of Surgery, Allegheny Health Network, Temple University, Pittsburgh, Pennsylvania; Department of Surgery, Pittsburgh VA Healthcare System, University Drive, Pittsburgh, Pennsylvania. Electronic address: georgemeid@hotmail.com.
authors: George M
authors: GM
authors: Eid
authors: Division of Minimally Invasive Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
authors: Carol
authors: C
authors: McCloskey
authors: Department of Surgery, Pittsburgh VA Healthcare System, University Drive, Pittsburgh, Pennsylvania.
authors: Rebecca
authors: R
authors: Titchner
authors: Department of Internal Medicine, Endocrinology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
authors: Mary
authors: M
authors: Korytkowski
authors: Division of Minimally Invasive Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
authors: Debra
authors: D
authors: Gross
authors: Division of Minimally Invasive Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
authors: Cynthia
authors: C
authors: Grabowski
authors: Department of Surgery, Pittsburgh VA Healthcare System, University Drive, Pittsburgh, Pennsylvania; Division of Minimally Invasive Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
authors: Mark
authors: M
authors: Wilson
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D015992:Body Mass Index; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D015390:Gastric Bypass; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D007986:Luteinizing Hormone / Q000378:metabolism; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000601:surgery; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000601:surgery*; D011446:Prospective Studies; D013739:Testosterone / Q000378:metabolism; D055815:Young Adult
chemical_list: D015415:Biomarkers; D006728:Hormones; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
keywords: Cholesterol; Hirsutism; Insulin; Menstrual irregularities; Testosterone