title: Noncoding RNAs and the control of hormonal signaling via nuclear receptor regulation.
abstract: Despite its identification over 100 years ago, new discoveries continue to add to the complexity of the regulation of the endocrine system. Today the nuclear receptors (NRs) that play such a pivotal role in the extensive communication networks of hormones and gene expression remain an area of intense research. By orchestrating core processes, from metabolism to organismal development, the gene expression programs they control are dependent on their cellular context, their own levels, and those of numerous co-regulatory proteins. A previously unknown component of these networks, noncoding RNAs (ncRNAs) are now recognized as potent regulators of NR signaling, influencing receptor and co-factor levels and functions while being reciprocally regulated by the NRs themselves. This review explores the regulation enacted by microRNAs and long ncRNAs on NR function, using representative examples to show the varied roles of ncRNAs, in turn producing significant effects on the NR functional network in health and disease.
authors: Department of Surgery and CancerImperial College London, Imperial Centre for Translational and Experimental Medicine, London W12 0NN, UK.
authors: Silvia
authors: S
authors: Ottaviani
authors: Department of Surgery and CancerImperial College London, Imperial Centre for Translational and Experimental Medicine, London W12 0NN, UK.
authors: Alexander
authors: A
authors: de Giorgio
authors: Department of Surgery and CancerImperial College London, Imperial Centre for Translational and Experimental Medicine, London W12 0NN, UK.
authors: Victoria
authors: V
authors: Harding
authors: Department of Surgery and CancerImperial College London, Imperial Centre for Translational and Experimental Medicine, London W12 0NN, UK.
authors: Justin
authors: J
authors: Stebbing
authors: Department of Surgery and CancerImperial College London, Imperial Centre for Translational and Experimental Medicine, London W12 0NN, UK l.castellano@imperial.ac.uk.
authors: Leandro
authors: L
authors: Castellano
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D062085:RNA, Long Noncoding / Q000235:genetics / Q000378:metabolism; D022661:RNA, Untranslated / Q000235:genetics* / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D006728:Hormones; D035683:MicroRNAs; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D018160:Receptors, Cytoplasmic and Nuclear
keywords: eRNA; lncRNA; miRNA; microRNA; noncoding RNA; nuclear receptors