title: Laparoscopic left hepatectomy with tumor thrombectomy in patients with hepatocellular carcinoma concomitant with advanced portal vein tumor thrombus.
abstract: BACKGROUND
  Although laparoscopic hepato-biliary-pancreatic surgery has been widely adopted, use of laparoscopic resection for hepatocellular carcinoma (HCC) with advanced portal vein tumor thrombus (PVTT) is uncommon because of the complications involved.
  
  
  METHODS
  From June 2010 through November 2013, 200 laparoscopic hepatectomies were performed. We report the short-term outcome of laparoscopic hepatectomy for HCC with advanced PVTT in 3 patients. Video presentation is a demonstration of the operative procedures employed in Case 3. In this case, the left hepatic artery and left hepatic duct were divided before tumor thrombectomy, and the bifurcation of the portal vein was clearly visible.
  
  
  RESULTS
  Three female patients with HCC concomitant with PVTT in the portal trunk or the opposite branch underwent laparoscopic left hepatectomy with tumor thrombectomy using a laparoscopy-assisted technique (1 patient) or pure laparoscopic technique (2 patients). The median operative time was 592 min (range, 555-891 min), and median estimated blood loss was 1182 ml (range, minimal amount-4800 ml). The median length of hospital stay was 19 days (range, 9-22 days), and there was no postoperative mortality. In Case 1, recurrent tumors developed in the residual lobe after curative resection, and the patient died 10 months after the surgery despite treatment with sorafenib and transcatheter arterial chemoembolization. In Case 2, the patient survived for 10 months after curative resection without tumor recurrence. In Case 3, the patient was treated with sorafenib 1 month after palliative resection; she survived for 4 postoperative months, during which decreased tumor marker levels were observed.
  
  
  CONCLUSIONS
  Laparoscopic hepatectomy for HCC with advanced PVTT is a safe and feasible procedure in selected patients, when performed by surgeons with expertise in hepatic surgery and minimally invasive techniques. Although these patients cannot be cured by surgery alone, early adjuvant therapy followed by laparoscopic surgery might contribute to a good outcome.
authors: Department of Digestive Surgery, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, 3-1 Aoyama-cho, Kure, Hiroshima, 737-0023, Japan, snakahira-gi@umin.ac.jp.
authors: Shin
authors: S
authors: Nakahira
authors: Yutaka
authors: Y
authors: Takeda
authors: Yoshiteru
authors: Y
authors: Katsura
authors: Takeshi
authors: T
authors: Kato
authors: Nobutaka
authors: N
authors: Hatanaka
authors: Shigeyuki
authors: S
authors: Tamura
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D008113:Liver Neoplasms / Q000150:complications / Q000601:surgery*; D009360:Neoplastic Cells, Circulating; D011169:Portal Vein; D017131:Thrombectomy / Q000379:methods*; D020246:Venous Thrombosis / Q000209:etiology / Q000601:surgery*