title: Olive oil polyphenols enhance high-density lipoprotein function in humans: a randomized controlled trial.
abstract: OBJECTIVE
  Olive oil polyphenols have shown beneficial properties against cardiovascular risk factors. Their consumption has been associated with higher cholesterol content in high-density lipoproteins (HDL). However, data on polyphenol effects on HDL quality are scarce. We, therefore, assessed whether polyphenol-rich olive oil consumption could enhance the HDL main function, its cholesterol efflux capacity, and some of its quality-related properties, such HDL polyphenol content, size, and composition.
  
  
  RESULTS
  A randomized, crossover, controlled trial with 47 healthy European male volunteers was performed. Participants ingested 25 mL/d of polyphenol-poor (2.7 mg/kg) or polyphenol-rich (366 mg/kg) raw olive oil in 3-week intervention periods, preceded by 2-week washout periods. HDL cholesterol efflux capacity significantly improved after polyphenol-rich intervention versus the polyphenol-poor one (+3.05% and -2.34%, respectively; P=0.042). Incorporation of olive oil polyphenol biological metabolites to HDL, as well as large HDL (HDL2) levels, was higher after the polyphenol-rich olive oil intervention, compared with the polyphenol-poor one. Small HDL (HDL3) levels decreased, the HDL core became triglyceride-poor, and HDL fluidity increased after the polyphenol-rich intervention.
  
  
  CONCLUSIONS
  Olive oil polyphenols promote the main HDL antiatherogenic function, its cholesterol efflux capacity. These polyphenols increased HDL size, promoted a greater HDL stability reflected as a triglyceride-poor core, and enhanced the HDL oxidative status, through an increase in the olive oil polyphenol metabolites content in the lipoprotein. Our results provide for the first time a first-level evidence of an enhancement in HDL function by polyphenol-rich olive oil.
authors: From the Cardiovascular Risk and Nutrition Research Group, REGICOR Study Group, CIBER de Fisiopatología de la Nutrición y la Obesidad (CIBEROBN) (A.H., M.F., D.M.-A., A.G.-G., O.D.-G., S.M.-P., M.-I.C., M.F.), Cardiovascular Epidemiology and Genetics Research Group, REGICOR Study Group, CIBER de Epidemiología y Salud Pública (CIBERESP) (I.S.), and Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), IMIM-Research Institute Hospital del Mar, Barcelona, Spain; Ph.D program of Food Sciences and Nutrition (A.H.) and Department of Nutrition and Bromatology, Faculty of Pharmacy (R.M.), Universitat de Barcelona, Barcelona, Spain; Research Unit on Lipids and Atherosclerosis, Hospital Universitari Sant Joan, IISPV, Universitat Rovira I Virgili and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Reus, Spain (S.F.-C., U.C., R.S., A.P.); Ph.D program in Biochemistry, Molecular Biology and Biomedicine, Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Barcelona, Spain (M.F.); Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland (K.N.); German Institute of Human Nutrition (DIFE), Potsdam-Rehbruecke, Germany (H.-J.F.Z.); and Lipoprotein Metabolism Section, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD (A.T.R.).
authors: Álvaro
authors: Á
authors: Hernáez
authors: From the Cardiovascular Risk and Nutrition Research Group, REGICOR Study Group, CIBER de Fisiopatología de la Nutrición y la Obesidad (CIBEROBN) (A.H., M.F., D.M.-A., A.G.-G., O.D.-G., S.M.-P., M.-I.C., M.F.), Cardiovascular Epidemiology and Genetics Research Group, REGICOR Study Group, CIBER de Epidemiología y Salud Pública (CIBERESP) (I.S.), and Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), IMIM-Research Institute Hospital del Mar, Barcelona, Spain; Ph.D program of Food Sciences and Nutrition (A.H.) and Department of Nutrition and Bromatology, Faculty of Pharmacy (R.M.), Universitat de Barcelona, Barcelona, Spain; Research Unit on Lipids and Atherosclerosis, Hospital Universitari Sant Joan, IISPV, Universitat Rovira I Virgili and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Reus, Spain (S.F.-C., U.C., R.S., A.P.); Ph.D program in Biochemistry, Molecular Biology and Biomedicine, Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Barcelona, Spain (M.F.); Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland (K.N.); German Institute of Human Nutrition (DIFE), Potsdam-Rehbruecke, Germany (H.-J.F.Z.); and Lipoprotein Metabolism Section, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD (A.T.R.).
authors: Sara
authors: S
authors: Fernández-Castillejo
authors: From the Cardiovascular Risk and Nutrition Research Group, REGICOR Study Group, CIBER de Fisiopatología de la Nutrición y la Obesidad (CIBEROBN) (A.H., M.F., D.M.-A., A.G.-G., O.D.-G., S.M.-P., M.-I.C., M.F.), Cardiovascular Epidemiology and Genetics Research Group, REGICOR Study Group, CIBER de Epidemiología y Salud Pública (CIBERESP) (I.S.), and Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), IMIM-Research Institute Hospital del Mar, Barcelona, Spain; Ph.D program of Food Sciences and Nutrition (A.H.) and Department of Nutrition and Bromatology, Faculty of Pharmacy (R.M.), Universitat de Barcelona, Barcelona, Spain; Research Unit on Lipids and Atherosclerosis, Hospital Universitari Sant Joan, IISPV, Universitat Rovira I Virgili and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Reus, Spain (S.F.-C., U.C., R.S., A.P.); Ph.D program in Biochemistry, Molecular Biology and Biomedicine, Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Barcelona, Spain (M.F.); Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland (K.N.); German Institute of Human Nutrition (DIFE), Potsdam-Rehbruecke, Germany (H.-J.F.Z.); and Lipoprotein Metabolism Section, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD (A.T.R.).
authors: Marta
authors: M
authors: Farràs
authors: From the Cardiovascular Risk and Nutrition Research Group, REGICOR Study Group, CIBER de Fisiopatología de la Nutrición y la Obesidad (CIBEROBN) (A.H., M.F., D.M.-A., A.G.-G., O.D.-G., S.M.-P., M.-I.C., M.F.), Cardiovascular Epidemiology and Genetics Research Group, REGICOR Study Group, CIBER de Epidemiología y Salud Pública (CIBERESP) (I.S.), and Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), IMIM-Research Institute Hospital del Mar, Barcelona, Spain; Ph.D program of Food Sciences and Nutrition (A.H.) and Department of Nutrition and Bromatology, Faculty of Pharmacy (R.M.), Universitat de Barcelona, Barcelona, Spain; Research Unit on Lipids and Atherosclerosis, Hospital Universitari Sant Joan, IISPV, Universitat Rovira I Virgili and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Reus, Spain (S.F.-C., U.C., R.S., A.P.); Ph.D program in Biochemistry, Molecular Biology and Biomedicine, Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Barcelona, Spain (M.F.); Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland (K.N.); German Institute of Human Nutrition (DIFE), Potsdam-Rehbruecke, Germany (H.-J.F.Z.); and Lipoprotein Metabolism Section, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD (A.T.R.).
authors: Úrsula
authors: Ú
authors: Catalán
authors: From the Cardiovascular Risk and Nutrition Research Group, REGICOR Study Group, CIBER de Fisiopatología de la Nutrición y la Obesidad (CIBEROBN) (A.H., M.F., D.M.-A., A.G.-G., O.D.-G., S.M.-P., M.-I.C., M.F.), Cardiovascular Epidemiology and Genetics Research Group, REGICOR Study Group, CIBER de Epidemiología y Salud Pública (CIBERESP) (I.S.), and Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), IMIM-Research Institute Hospital del Mar, Barcelona, Spain; Ph.D program of Food Sciences and Nutrition (A.H.) and Department of Nutrition and Bromatology, Faculty of Pharmacy (R.M.), Universitat de Barcelona, Barcelona, Spain; Research Unit on Lipids and Atherosclerosis, Hospital Universitari Sant Joan, IISPV, Universitat Rovira I Virgili and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Reus, Spain (S.F.-C., U.C., R.S., A.P.); Ph.D program in Biochemistry, Molecular Biology and Biomedicine, Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Barcelona, Spain (M.F.); Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland (K.N.); German Institute of Human Nutrition (DIFE), Potsdam-Rehbruecke, Germany (H.-J.F.Z.); and Lipoprotein Metabolism Section, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD (A.T.R.).
authors: Isaac
authors: I
authors: Subirana
authors: From the Cardiovascular Risk and Nutrition Research Group, REGICOR Study Group, CIBER de Fisiopatología de la Nutrición y la Obesidad (CIBEROBN) (A.H., M.F., D.M.-A., A.G.-G., O.D.-G., S.M.-P., M.-I.C., M.F.), Cardiovascular Epidemiology and Genetics Research Group, REGICOR Study Group, CIBER de Epidemiología y Salud Pública (CIBERESP) (I.S.), and Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), IMIM-Research Institute Hospital del Mar, Barcelona, Spain; Ph.D program of Food Sciences and Nutrition (A.H.) and Department of Nutrition and Bromatology, Faculty of Pharmacy (R.M.), Universitat de Barcelona, Barcelona, Spain; Research Unit on Lipids and Atherosclerosis, Hospital Universitari Sant Joan, IISPV, Universitat Rovira I Virgili and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Reus, Spain (S.F.-C., U.C., R.S., A.P.); Ph.D program in Biochemistry, Molecular Biology and Biomedicine, Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Barcelona, Spain (M.F.); Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland (K.N.); German Institute of Human Nutrition (DIFE), Potsdam-Rehbruecke, Germany (H.-J.F.Z.); and Lipoprotein Metabolism Section, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD (A.T.R.).
authors: Rosa
authors: R
authors: Montes
authors: From the Cardiovascular Risk and Nutrition Research Group, REGICOR Study Group, CIBER de Fisiopatología de la Nutrición y la Obesidad (CIBEROBN) (A.H., M.F., D.M.-A., A.G.-G., O.D.-G., S.M.-P., M.-I.C., M.F.), Cardiovascular Epidemiology and Genetics Research Group, REGICOR Study Group, CIBER de Epidemiología y Salud Pública (CIBERESP) (I.S.), and Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), IMIM-Research Institute Hospital del Mar, Barcelona, Spain; Ph.D program of Food Sciences and Nutrition (A.H.) and Department of Nutrition and Bromatology, Faculty of Pharmacy (R.M.), Universitat de Barcelona, Barcelona, Spain; Research Unit on Lipids and Atherosclerosis, Hospital Universitari Sant Joan, IISPV, Universitat Rovira I Virgili and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Reus, Spain (S.F.-C., U.C., R.S., A.P.); Ph.D program in Biochemistry, Molecular Biology and Biomedicine, Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Barcelona, Spain (M.F.); Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland (K.N.); German Institute of Human Nutrition (DIFE), Potsdam-Rehbruecke, Germany (H.-J.F.Z.); and Lipoprotein Metabolism Section, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD (A.T.R.).
authors: Rosa
authors: R
authors: Solà
authors: From the Cardiovascular Risk and Nutrition Research Group, REGICOR Study Group, CIBER de Fisiopatología de la Nutrición y la Obesidad (CIBEROBN) (A.H., M.F., D.M.-A., A.G.-G., O.D.-G., S.M.-P., M.-I.C., M.F.), Cardiovascular Epidemiology and Genetics Research Group, REGICOR Study Group, CIBER de Epidemiología y Salud Pública (CIBERESP) (I.S.), and Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), IMIM-Research Institute Hospital del Mar, Barcelona, Spain; Ph.D program of Food Sciences and Nutrition (A.H.) and Department of Nutrition and Bromatology, Faculty of Pharmacy (R.M.), Universitat de Barcelona, Barcelona, Spain; Research Unit on Lipids and Atherosclerosis, Hospital Universitari Sant Joan, IISPV, Universitat Rovira I Virgili and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Reus, Spain (S.F.-C., U.C., R.S., A.P.); Ph.D program in Biochemistry, Molecular Biology and Biomedicine, Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Barcelona, Spain (M.F.); Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland (K.N.); German Institute of Human Nutrition (DIFE), Potsdam-Rehbruecke, Germany (H.-J.F.Z.); and Lipoprotein Metabolism Section, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD (A.T.R.).
authors: Daniel
authors: D
authors: Muñoz-Aguayo
authors: From the Cardiovascular Risk and Nutrition Research Group, REGICOR Study Group, CIBER de Fisiopatología de la Nutrición y la Obesidad (CIBEROBN) (A.H., M.F., D.M.-A., A.G.-G., O.D.-G., S.M.-P., M.-I.C., M.F.), Cardiovascular Epidemiology and Genetics Research Group, REGICOR Study Group, CIBER de Epidemiología y Salud Pública (CIBERESP) (I.S.), and Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), IMIM-Research Institute Hospital del Mar, Barcelona, Spain; Ph.D program of Food Sciences and Nutrition (A.H.) and Department of Nutrition and Bromatology, Faculty of Pharmacy (R.M.), Universitat de Barcelona, Barcelona, Spain; Research Unit on Lipids and Atherosclerosis, Hospital Universitari Sant Joan, IISPV, Universitat Rovira I Virgili and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Reus, Spain (S.F.-C., U.C., R.S., A.P.); Ph.D program in Biochemistry, Molecular Biology and Biomedicine, Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Barcelona, Spain (M.F.); Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland (K.N.); German Institute of Human Nutrition (DIFE), Potsdam-Rehbruecke, Germany (H.-J.F.Z.); and Lipoprotein Metabolism Section, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD (A.T.R.).
authors: Anna
authors: A
authors: Gelabert-Gorgues
authors: From the Cardiovascular Risk and Nutrition Research Group, REGICOR Study Group, CIBER de Fisiopatología de la Nutrición y la Obesidad (CIBEROBN) (A.H., M.F., D.M.-A., A.G.-G., O.D.-G., S.M.-P., M.-I.C., M.F.), Cardiovascular Epidemiology and Genetics Research Group, REGICOR Study Group, CIBER de Epidemiología y Salud Pública (CIBERESP) (I.S.), and Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), IMIM-Research Institute Hospital del Mar, Barcelona, Spain; Ph.D program of Food Sciences and Nutrition (A.H.) and Department of Nutrition and Bromatology, Faculty of Pharmacy (R.M.), Universitat de Barcelona, Barcelona, Spain; Research Unit on Lipids and Atherosclerosis, Hospital Universitari Sant Joan, IISPV, Universitat Rovira I Virgili and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Reus, Spain (S.F.-C., U.C., R.S., A.P.); Ph.D program in Biochemistry, Molecular Biology and Biomedicine, Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Barcelona, Spain (M.F.); Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland (K.N.); German Institute of Human Nutrition (DIFE), Potsdam-Rehbruecke, Germany (H.-J.F.Z.); and Lipoprotein Metabolism Section, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD (A.T.R.).
authors: Óscar
authors: Ó
authors: Díaz-Gil
authors: From the Cardiovascular Risk and Nutrition Research Group, REGICOR Study Group, CIBER de Fisiopatología de la Nutrición y la Obesidad (CIBEROBN) (A.H., M.F., D.M.-A., A.G.-G., O.D.-G., S.M.-P., M.-I.C., M.F.), Cardiovascular Epidemiology and Genetics Research Group, REGICOR Study Group, CIBER de Epidemiología y Salud Pública (CIBERESP) (I.S.), and Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), IMIM-Research Institute Hospital del Mar, Barcelona, Spain; Ph.D program of Food Sciences and Nutrition (A.H.) and Department of Nutrition and Bromatology, Faculty of Pharmacy (R.M.), Universitat de Barcelona, Barcelona, Spain; Research Unit on Lipids and Atherosclerosis, Hospital Universitari Sant Joan, IISPV, Universitat Rovira I Virgili and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Reus, Spain (S.F.-C., U.C., R.S., A.P.); Ph.D program in Biochemistry, Molecular Biology and Biomedicine, Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Barcelona, Spain (M.F.); Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland (K.N.); German Institute of Human Nutrition (DIFE), Potsdam-Rehbruecke, Germany (H.-J.F.Z.); and Lipoprotein Metabolism Section, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD (A.T.R.).
authors: Kristiina
authors: K
authors: Nyyssönen
authors: From the Cardiovascular Risk and Nutrition Research Group, REGICOR Study Group, CIBER de Fisiopatología de la Nutrición y la Obesidad (CIBEROBN) (A.H., M.F., D.M.-A., A.G.-G., O.D.-G., S.M.-P., M.-I.C., M.F.), Cardiovascular Epidemiology and Genetics Research Group, REGICOR Study Group, CIBER de Epidemiología y Salud Pública (CIBERESP) (I.S.), and Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), IMIM-Research Institute Hospital del Mar, Barcelona, Spain; Ph.D program of Food Sciences and Nutrition (A.H.) and Department of Nutrition and Bromatology, Faculty of Pharmacy (R.M.), Universitat de Barcelona, Barcelona, Spain; Research Unit on Lipids and Atherosclerosis, Hospital Universitari Sant Joan, IISPV, Universitat Rovira I Virgili and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Reus, Spain (S.F.-C., U.C., R.S., A.P.); Ph.D program in Biochemistry, Molecular Biology and Biomedicine, Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Barcelona, Spain (M.F.); Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland (K.N.); German Institute of Human Nutrition (DIFE), Potsdam-Rehbruecke, Germany (H.-J.F.Z.); and Lipoprotein Metabolism Section, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD (A.T.R.).
authors: Hans-Joachim F
authors: HJ
authors: Zunft
authors: From the Cardiovascular Risk and Nutrition Research Group, REGICOR Study Group, CIBER de Fisiopatología de la Nutrición y la Obesidad (CIBEROBN) (A.H., M.F., D.M.-A., A.G.-G., O.D.-G., S.M.-P., M.-I.C., M.F.), Cardiovascular Epidemiology and Genetics Research Group, REGICOR Study Group, CIBER de Epidemiología y Salud Pública (CIBERESP) (I.S.), and Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), IMIM-Research Institute Hospital del Mar, Barcelona, Spain; Ph.D program of Food Sciences and Nutrition (A.H.) and Department of Nutrition and Bromatology, Faculty of Pharmacy (R.M.), Universitat de Barcelona, Barcelona, Spain; Research Unit on Lipids and Atherosclerosis, Hospital Universitari Sant Joan, IISPV, Universitat Rovira I Virgili and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Reus, Spain (S.F.-C., U.C., R.S., A.P.); Ph.D program in Biochemistry, Molecular Biology and Biomedicine, Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Barcelona, Spain (M.F.); Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland (K.N.); German Institute of Human Nutrition (DIFE), Potsdam-Rehbruecke, Germany (H.-J.F.Z.); and Lipoprotein Metabolism Section, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD (A.T.R.).
authors: Rafael
authors: R
authors: de la Torre
authors: From the Cardiovascular Risk and Nutrition Research Group, REGICOR Study Group, CIBER de Fisiopatología de la Nutrición y la Obesidad (CIBEROBN) (A.H., M.F., D.M.-A., A.G.-G., O.D.-G., S.M.-P., M.-I.C., M.F.), Cardiovascular Epidemiology and Genetics Research Group, REGICOR Study Group, CIBER de Epidemiología y Salud Pública (CIBERESP) (I.S.), and Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), IMIM-Research Institute Hospital del Mar, Barcelona, Spain; Ph.D program of Food Sciences and Nutrition (A.H.) and Department of Nutrition and Bromatology, Faculty of Pharmacy (R.M.), Universitat de Barcelona, Barcelona, Spain; Research Unit on Lipids and Atherosclerosis, Hospital Universitari Sant Joan, IISPV, Universitat Rovira I Virgili and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Reus, Spain (S.F.-C., U.C., R.S., A.P.); Ph.D program in Biochemistry, Molecular Biology and Biomedicine, Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Barcelona, Spain (M.F.); Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland (K.N.); German Institute of Human Nutrition (DIFE), Potsdam-Rehbruecke, Germany (H.-J.F.Z.); and Lipoprotein Metabolism Section, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD (A.T.R.).
authors: Sandra
authors: S
authors: Martín-Peláez
authors: From the Cardiovascular Risk and Nutrition Research Group, REGICOR Study Group, CIBER de Fisiopatología de la Nutrición y la Obesidad (CIBEROBN) (A.H., M.F., D.M.-A., A.G.-G., O.D.-G., S.M.-P., M.-I.C., M.F.), Cardiovascular Epidemiology and Genetics Research Group, REGICOR Study Group, CIBER de Epidemiología y Salud Pública (CIBERESP) (I.S.), and Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), IMIM-Research Institute Hospital del Mar, Barcelona, Spain; Ph.D program of Food Sciences and Nutrition (A.H.) and Department of Nutrition and Bromatology, Faculty of Pharmacy (R.M.), Universitat de Barcelona, Barcelona, Spain; Research Unit on Lipids and Atherosclerosis, Hospital Universitari Sant Joan, IISPV, Universitat Rovira I Virgili and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Reus, Spain (S.F.-C., U.C., R.S., A.P.); Ph.D program in Biochemistry, Molecular Biology and Biomedicine, Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Barcelona, Spain (M.F.); Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland (K.N.); German Institute of Human Nutrition (DIFE), Potsdam-Rehbruecke, Germany (H.-J.F.Z.); and Lipoprotein Metabolism Section, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD (A.T.R.).
authors: Anna
authors: A
authors: Pedret
authors: From the Cardiovascular Risk and Nutrition Research Group, REGICOR Study Group, CIBER de Fisiopatología de la Nutrición y la Obesidad (CIBEROBN) (A.H., M.F., D.M.-A., A.G.-G., O.D.-G., S.M.-P., M.-I.C., M.F.), Cardiovascular Epidemiology and Genetics Research Group, REGICOR Study Group, CIBER de Epidemiología y Salud Pública (CIBERESP) (I.S.), and Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), IMIM-Research Institute Hospital del Mar, Barcelona, Spain; Ph.D program of Food Sciences and Nutrition (A.H.) and Department of Nutrition and Bromatology, Faculty of Pharmacy (R.M.), Universitat de Barcelona, Barcelona, Spain; Research Unit on Lipids and Atherosclerosis, Hospital Universitari Sant Joan, IISPV, Universitat Rovira I Virgili and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Reus, Spain (S.F.-C., U.C., R.S., A.P.); Ph.D program in Biochemistry, Molecular Biology and Biomedicine, Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Barcelona, Spain (M.F.); Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland (K.N.); German Institute of Human Nutrition (DIFE), Potsdam-Rehbruecke, Germany (H.-J.F.Z.); and Lipoprotein Metabolism Section, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD (A.T.R.).
authors: Alan T
authors: AT
authors: Remaley
authors: From the Cardiovascular Risk and Nutrition Research Group, REGICOR Study Group, CIBER de Fisiopatología de la Nutrición y la Obesidad (CIBEROBN) (A.H., M.F., D.M.-A., A.G.-G., O.D.-G., S.M.-P., M.-I.C., M.F.), Cardiovascular Epidemiology and Genetics Research Group, REGICOR Study Group, CIBER de Epidemiología y Salud Pública (CIBERESP) (I.S.), and Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), IMIM-Research Institute Hospital del Mar, Barcelona, Spain; Ph.D program of Food Sciences and Nutrition (A.H.) and Department of Nutrition and Bromatology, Faculty of Pharmacy (R.M.), Universitat de Barcelona, Barcelona, Spain; Research Unit on Lipids and Atherosclerosis, Hospital Universitari Sant Joan, IISPV, Universitat Rovira I Virgili and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Reus, Spain (S.F.-C., U.C., R.S., A.P.); Ph.D program in Biochemistry, Molecular Biology and Biomedicine, Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Barcelona, Spain (M.F.); Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland (K.N.); German Institute of Human Nutrition (DIFE), Potsdam-Rehbruecke, Germany (H.-J.F.Z.); and Lipoprotein Metabolism Section, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD (A.T.R.).
authors: María-Isabel
authors: MI
authors: Covas
authors: From the Cardiovascular Risk and Nutrition Research Group, REGICOR Study Group, CIBER de Fisiopatología de la Nutrición y la Obesidad (CIBEROBN) (A.H., M.F., D.M.-A., A.G.-G., O.D.-G., S.M.-P., M.-I.C., M.F.), Cardiovascular Epidemiology and Genetics Research Group, REGICOR Study Group, CIBER de Epidemiología y Salud Pública (CIBERESP) (I.S.), and Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), IMIM-Research Institute Hospital del Mar, Barcelona, Spain; Ph.D program of Food Sciences and Nutrition (A.H.) and Department of Nutrition and Bromatology, Faculty of Pharmacy (R.M.), Universitat de Barcelona, Barcelona, Spain; Research Unit on Lipids and Atherosclerosis, Hospital Universitari Sant Joan, IISPV, Universitat Rovira I Virgili and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Reus, Spain (S.F.-C., U.C., R.S., A.P.); Ph.D program in Biochemistry, Molecular Biology and Biomedicine, Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Barcelona, Spain (M.F.); Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland (K.N.); German Institute of Human Nutrition (DIFE), Potsdam-Rehbruecke, Germany (H.-J.F.Z.); and Lipoprotein Metabolism Section, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD (A.T.R.). mfito@imim.es.
authors: Montserrat
authors: M
authors: Fitó
mesh_terms: D000328:Adult; D045744:Cell Line, Tumor; D002784:Cholesterol / Q000097:blood*; D018592:Cross-Over Studies; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008075:Lipoproteins, HDL / Q000187:drug effects* / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D008297:Male; D000069463:Olive Oil; D010938:Plant Oils / Q000737:chemistry*; D059808:Polyphenols / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood
chemical_list: D004042:Dietary Fats, Unsaturated; D008075:Lipoproteins, HDL; D000069463:Olive Oil; D010938:Plant Oils; D059808:Polyphenols; D014280:Triglycerides; D002784:Cholesterol
keywords: diet; high-density lipoproteins; olive oil