title: Noncontact quantitative biomechanical characterization of cardiac muscle using shear wave imaging optical coherence tomography.
abstract: We report on a quantitative optical elastographic method based on shear wave imaging optical coherence tomography (SWI-OCT) for biomechanical characterization of cardiac muscle through noncontact elasticity measurement. The SWI-OCT system employs a focused air-puff device for localized loading of the cardiac muscle and utilizes phase-sensitive OCT to monitor the induced tissue deformation. Phase information from the optical interferometry is used to reconstruct 2-D depth-resolved shear wave propagation inside the muscle tissue. Cross-correlation of the displacement profiles at various spatial locations in the propagation direction is applied to measure the group velocity of the shear waves, based on which the Young's modulus of tissue is quantified. The quantitative feature and measurement accuracy of this method is demonstrated from the experiments on tissue-mimicking phantoms with the verification using uniaxial compression test. The experiments are performed on ex vivo cardiac muscle tissue from mice with normal and genetically altered myocardium. Our results indicate this optical elastographic technique is useful as a noncontact tool to assist the cardiac muscle studies.
authors: Department of Biomedical Engineering, University of Houston, 3605 Cullen Blvd., Houston, Texas 77204-5060, USA.
authors: Shang
authors: S
authors: Wang
authors: Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Texas, USA.
authors: Andrew L
authors: AL
authors: Lopez
authors: Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Texas, USA.
authors: Yuka
authors: Y
authors: Morikawa
authors: Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Texas, USA.
authors: Ge
authors: G
authors: Tao
authors: Department of Biomedical Engineering, University of Houston, 3605 Cullen Blvd., Houston, Texas 77204-5060, USA.
authors: Jiasong
authors: J
authors: Li
authors: Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Texas, USA.
authors: Irina V
authors: IV
authors: Larina
authors: Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Texas, USA ; Texas Heart Institute, Houston, Texas 77030, USA.
authors: James F
authors: JF
authors: Martin
authors: Department of Biomedical Engineering, University of Houston, 3605 Cullen Blvd., Houston, Texas 77204-5060, USA ; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Texas, USA.
authors: Kirill V
authors: KV
authors: Larin
keywords: (170.4500) Optical coherence tomography; (170.6935) Tissue characterization