title: Expression of circadian rhythm genes CLOCK, BMAL1, and PER1 in buccal epithelial cells of patients with essential arterial hypertension in dependence on polymorphic variants of CLOCK and BMAL1 genes.
abstract: The transcript levels of circadian rhythm genes CLOCK, BMAL1, and PER1 in buccal epithelial cells of the patients with essential arterial hypertension was analyzed in relation to polymorphic variants of CLOCK and BMAL1 genes. These levels were assessed with realtime PCR method at daily hours 9, 13, and 17. The significant differences were revealed in transcript levels of the examined genes in patients with various genotypes at the polymorphic markers 3111TC and 257TG regulatory regions of CLOCK gene. The study detected no significant differences among the carriers of various genotypes at polymorphic markers 862TC and 2121GA of CLOCK gene and 56445TC of BMAL1 gene.
authors: Institute of Biology, Karelian Scientific Center, Russian Academy of Sciences, Petrozavodsk, Russia, irina7m@yandex.ru.
authors: I V
authors: IV
authors: Kurbatova
authors: L V
authors: LV
authors: Topchieva
authors: V A
authors: VA
authors: Korneva
authors: S N
authors: SN
authors: Kolomeichuk
authors: N N
authors: NN
authors: Nemova
mesh_terms: D056930:ARNTL Transcription Factors / Q000235:genetics / Q000378:metabolism*; D056926:CLOCK Proteins / Q000235:genetics / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism*; D000075222:Essential Hypertension; D005260:Female; D015870:Gene Expression; D005786:Gene Expression Regulation; D056726:Genetic Association Studies; D006801:Humans; D006973:Hypertension / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000378:metabolism* / Q000473:pathology; D056950:Period Circadian Proteins / Q000235:genetics / Q000378:metabolism*; D020641:Polymorphism, Single Nucleotide
chemical_list: D056930:ARNTL Transcription Factors; C538960:BMAL1 protein, human; C539022:PER1 protein, human; D056950:Period Circadian Proteins; D056926:CLOCK Proteins; C538943:CLOCK protein, human