title: One-pot asymmetric synthesis of quaternary pyrroloindolones through a multicatalytic N-allylation/hydroacylation sequence.
abstract: An intramolecular, quaternary carbon center forming hydroacylation of α-substituted acrylates has been discovered. This interesting transformation can be readily incorporated into a multicatalytic tandem process enabled by a combination of nucleophilic tertiary amine and N-heterocyclic carbene catalysis. With no additional stoichiometric base required, this transformation affords the quaternary pyrroloindolones with high levels of enantioselectivity.
authors: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000 (P. R. China), Fax: (+86) 931-8915557.
authors: Hong
authors: H
authors: Lu
authors: Jun-Bing
authors: JB
authors: Lin
authors: Jin-Yu
authors: JY
authors: Liu
authors: Peng-Fei
authors: PF
authors: Xu
keywords: asymmetric catalysis; carbenes; hydroacylation; indoles; multicatalysis