title: Critical congenital heart disease screening by pulse oximetry in a neonatal intensive care unit.
abstract: OBJECTIVE
  Critical congenital heart disease (CCHD) screening is effective in asymptomatic late preterm and term newborn infants with a low false-positive rate (0.035%). (1) To compare 2817 neonatal intensive care unit (NICU) discharges before and after implementation of CCHD screening; and (2) to evaluate CCHD screening at <35 weeks gestation.
  
  
  METHODS
  Collection of results of CCHD screening including pre- and postductal pulse oximetry oxygen saturation (SpO2) values.
  
  
  RESULTS
  During the pre-CCHD screen period, 1247 infants were discharged from the NICU and one case of CCHD was missed. After 1 March 2012, 1508 CCHD screens were performed among 1570 discharges and no CCHDs were missed. The pre- and postductal SpO2 values were 98.8 ± 1.4% and 99 ± 1.3%, respectively, in preterm and 98.9 ± 1.3% and 98.9 ± 1.4%, respectively, in term infants. Ten infants had false-positive screens (10/1508 = 0.66%).
  
  
  CONCLUSIONS
  Performing universal screening in the NICU is feasible but is associated with a higher false-positive rate compared with asymptomatic newborn infants.
authors: 1] Divisions of Cardiology, State University of New York at Buffalo, Buffalo, NY, USA [2] Clinical Epidemiology and Biostatistics (Health-Research Methodology), McMasters University, Hamilton, ON, Canada.
authors: V
authors: V
authors: Manja
authors: Division of Neonatal-Perinatal Medicine, Women and Children's Hospital of Buffalo, State University of New York at Buffalo, Buffalo, NY, USA.
authors: B
authors: B
authors: Mathew
authors: Division of Neonatal-Perinatal Medicine, Women and Children's Hospital of Buffalo, State University of New York at Buffalo, Buffalo, NY, USA.
authors: V
authors: V
authors: Carrion
authors: Division of Neonatal-Perinatal Medicine, Women and Children's Hospital of Buffalo, State University of New York at Buffalo, Buffalo, NY, USA.
authors: S
authors: S
authors: Lakshminrusimha
mesh_terms: D005189:False Positive Reactions; D006330:Heart Defects, Congenital / Q000175:diagnosis*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007363:Intensive Care Units, Neonatal; D010092:Oximetry