title: [3 + 3]-cycloaddition reactions of α-acidic isocyanides with 1,3-dipolar azomethine imines.
abstract: α-Acidic isocyanides are versatile reagents in organic synthesis, especially for the synthesis of five-membered heterocycles via [3 + 2]-cycloaddition reactions with activated multiple bonds. In this communication, the first [3 + 3]-cross-cycloaddition of α-acidic isocyanides with 1,3-dipolar azomethine imines to generate a series of 1,2,4-triazine derivatives with significant regiochemical control under mild catalytic reaction conditions is described. This new strategy shows that α-acidic isocyanides can also be taken as potent reagents for the synthesis of six-membered heterocycles through [3 + 3]-cross-cycloaddition reactions with 1,3-dipoles.
authors: Department of Chemistry, Northeast Normal University , Changchun 130024, China.
authors: Juan
authors: J
authors: Du
authors: Xianxiu
authors: X
authors: Xu
authors: Yifei
authors: Y
authors: Li
authors: Ling
authors: L
authors: Pan
authors: Qun
authors: Q
authors: Liu