title: Whey versus soy protein diets and renal status in rats.
abstract: Different dietary protein sources can promote different renal statuses. We examined the effects of whey protein (WP) and soy protein (SP) intake on plasma, urinary, and morphological renal parameters in rats. One hundred and twenty Wistar rats were randomly distributed into 2 experimental groups fed with either WP or SP diets over 12 weeks. These diets were based on commercial WP or SP isolates. The urinary calcium content was higher in the WP diet compared to the SP diet group (P<.001) whereas the urinary citrate level was lower (P<.001). The urinary pH was more acidic in the WP diet group compared to the SP diet group (P<.001); however, no differences were observed between the groups for any of the renal morphological parameters analyzed (all, P>.05) or other plasma renal markers such as albumin or urea concentrations. The increase of acid and urinary calcium and the lower urinary citrate level observed in the WP diet group could increase the incidence of nephrolithiasis compared to the SP diet group. Despite the WP showed poorer acid-base profile, no significant morphological renal changes were observed. These results suggest that the use of SP instead of WP appears to promote a more alkaline plasma and urinary profile, with their consequent renal advantages.
authors: 1 Department of Physiology, School of Pharmacy and Institute of Nutrition and Food Technology, University of Granada , Granada, Spain .
authors: Virginia A
authors: VA
authors: Aparicio
authors: Elena
authors: E
authors: Nebot
authors: Mohamed
authors: M
authors: Tassi
authors: Daniel
authors: D
authors: Camiletti-Moirón
authors: Cristina
authors: C
authors: Sanchez-Gonzalez
authors: Jesús M
authors: JM
authors: Porres
authors: Pilar
authors: P
authors: Aranda
mesh_terms: D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000818:Animals; D002118:Calcium / Q000652:urine*; D019343:Citric Acid / Q000652:urine*; D004032:Diet; D004044:Dietary Proteins / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008894:Milk Proteins / Q000494:pharmacology*; D017208:Rats, Wistar; D030262:Soybean Proteins / Q000494:pharmacology*; D013025:Glycine max; D000067816:Whey Proteins
chemical_list: D004044:Dietary Proteins; D008894:Milk Proteins; D030262:Soybean Proteins; D000067816:Whey Proteins; D019343:Citric Acid; D002118:Calcium
keywords: acidosis; kidney; protein; rats; renal morphology; soy protein; urine; whey