title: Association of serum YKL-40 with the presence and severity of obstructive sleep apnea syndrome.
abstract: OBJECTIVE
  This study examined the association of serum YKL-40 concentrations with the presence and severity of obstructive sleep apnea syndrome (OSAS).
  
  
  METHODS
  A total of 156 patients with OSAS and 110 healthy subjects were enrolled in this study.
  
  
  RESULTS
  OSAS patients had significantly higher serum YKL-40 levels compared with healthy controls. Multivariable logistic regression analysis indicated that serum YKL-40 levels were an independent determinant of the presence of OSAS. Serum YKL-40 levels were significantly elevated in severe OSAS patients compared with mild and moderate OSAS patients. Spearman correlation analysis revealed that serum YKL-40 levels were correlated with the severity of OSAS. Simple linear regression analysis showed that the serum levels of YKL-40 were correlated with body mass index (BMI), homeostasis model assessment of insulin resistance (HOMA-IR), C-reactive protein (CRP), and apnea-hypopnea index (AHI) in patients with OSAS.
  
  
  CONCLUSIONS
  Elevated serum YKL-40 levels are associated with the presence and severity of OSAS.
authors: Department of Respiration, Chinese Medicine Hospital of Chongqing, Chongqing;
authors: Wei
authors: W
authors: Li
authors: Department of Respiration, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
authors: Zhen
authors: Z
authors: Yu
authors: Department of Respiration, Chinese Medicine Hospital of Chongqing, Chongqing; cmj_jcc@126.com.
authors: Chengcheng
authors: C
authors: Jiang
mesh_terms: D054392:Adipokines / Q000097:blood*; D000328:Adult; D016022:Case-Control Studies; D000071451:Chitinase-3-Like Protein 1; D006801:Humans; D037102:Lectins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000473:pathology
chemical_list: D054392:Adipokines; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1; D037102:Lectins
keywords: YKL-40; inflammation; obstructive sleep apnea syndrome; severity