title: Peganumine A, a β-carboline dimer with a new octacyclic scaffold from Peganum harmala.
abstract: Peganumine A (1), a new dimeric β-carboline alkaloid characterized by a unique 3,9-diazatetracyclo[6.5.2.0(1,9).0(3,8)]pentadec-2-one scaffold, was isolated from the seeds of Peganum harmala. The structure including the absolute configuration was determined by spectroscopic data, X-ray crystallography, ECD calculation, and CD exciton chirality approaches. Compound 1 showed moderate cytotoxic activity against MCF-7, PC-3, and HepG2 cells and selective effects on HL-60 cells with an IC50 value of 5.8 μM.
authors: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University , Shenyang 110016, Liaoning, P. R. China.
authors: Kai-Bo
authors: KB
authors: Wang
authors: Ying-Tong
authors: YT
authors: Di
authors: Yu
authors: Y
authors: Bao
authors: Chun-Mao
authors: CM
authors: Yuan
authors: Gang
authors: G
authors: Chen
authors: Da-Hong
authors: DH
authors: Li
authors: Jiao
authors: J
authors: Bai
authors: Hong-Ping
authors: HP
authors: He
authors: Xiao-Jiang
authors: XJ
authors: Hao
authors: Yue-Hu
authors: YH
authors: Pei
authors: Yong-Kui
authors: YK
authors: Jing
authors: Zhan-Lin
authors: ZL
authors: Li
authors: Hui-Ming
authors: HM
authors: Hua
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002243:Carbolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D056945:Hep G2 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D008968:Molecular Conformation; D015394:Molecular Structure; D032443:Peganum / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D002243:Carbolines; C000592085:peganumine A