title: Impact of medium and long chain triglycerides consumption on appetite and food intake in overweight men.
abstract: BACKGROUND
  Medium chain triglycerides (MCT) enhance thermogenesis and may reduce food intake relative to long chain triglycerides (LCT). The goal of this study was to establish the effects of MCT on appetite and food intake and determine whether differences were due to differences in hormone concentrations.
  
  
  METHODS
  Two randomized, crossover studies were conducted in which overweight men consumed 20 g of MCT or corn oil (LCT) at breakfast. Blood samples were obtained over 3 h. In Study 1 (n=10), an ad lib lunch was served after 3 h. In Study 2 (n=7), a preload containing 10 g of test oil was given at 3 h and lunch was served 1 h later. Linear mixed model analyses were performed to determine the effects of MCT and LCT oil on change in hormones and metabolites from fasting, adjusting for body weight. Correlations were computed between differences in hormones just before the test meals and differences in intakes after the two oils for Study 1 only.
  
  
  RESULTS
  Food intake at the lunch test meal after the MCT preload (Study 2) was (mean±s.e.m.) 532±389 kcal vs 804±486 kcal after LCT (P<0.05). MCT consumption resulted in a lower rise in triglycerides (P=0.014) and glucose (P=0.066) and a higher rise in peptide YY (PYY, P=0.017) and leptin (P=0.036) compared with LCT (combined data). Correlations between differences in hormone levels (glucagon-like peptide (GLP-1), PYY) and differences in food intake were in the opposite direction to expectations.
  
  
  CONCLUSIONS
  MCT consumption reduced food intake acutely but this does not seem to be mediated by changes in GLP-1, PYY and insulin.
authors: 1] College of Physicians and Surgeons, Columbia University, New York, NY, USA [2] New York Obesity Nutrition Research Center, St. Luke's/Roosevelt Hospital, New York, NY, USA.
authors: M-P
authors: MP
authors: St-Onge
authors: College of Physicians and Surgeons, Columbia University, New York, NY, USA.
authors: B
authors: B
authors: Mayrsohn
authors: 1] College of Physicians and Surgeons, Columbia University, New York, NY, USA [2] New York Obesity Nutrition Research Center, St. Luke's/Roosevelt Hospital, New York, NY, USA.
authors: M
authors: M
authors: O'Keeffe
authors: 1] College of Physicians and Surgeons, Columbia University, New York, NY, USA [2] New York Obesity Nutrition Research Center, St. Luke's/Roosevelt Hospital, New York, NY, USA.
authors: H R
authors: HR
authors: Kissileff
authors: Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY, USA.
authors: A R
authors: AR
authors: Choudhury
authors: New York Obesity Nutrition Research Center, St. Luke's/Roosevelt Hospital, New York, NY, USA.
authors: B
authors: B
authors: Laferrère
mesh_terms: D000328:Adult; D001066:Appetite / Q000187:drug effects*; D001786:Blood Glucose / Q000187:drug effects; D003314:Corn Oil / Q000378:metabolism; D018592:Cross-Over Studies; D004435:Eating / Q000187:drug effects*; D054439:Ghrelin / Q000097:blood / Q000187:drug effects; D052216:Glucagon-Like Peptide 1 / Q000097:blood / Q000187:drug effects; D006801:Humans; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000097:blood*; D019894:Peptide YY / Q000097:blood / Q000187:drug effects; D016037:Single-Blind Method; D014280:Triglycerides / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D054439:Ghrelin; D007328:Insulin; D020738:Leptin; D014280:Triglycerides; D019894:Peptide YY; D003314:Corn Oil; D052216:Glucagon-Like Peptide 1