title: Phospholipids profiling and outcome of peritoneal dialysis patients.
abstract: OBJECTIVE
  To investigate phospholipids (PLs) biomarkers in predicting outcome of patients undergoing peritoneal dialysis (PD).
  
  
  METHODS
  Twenty PD patients were followed using baseline plasma PLs with an improved online two-dimensional liquid chromatography-quadrupole time-of-flight mass spectrometry system.
  
  
  RESULTS
  Significant differences were observed in eight PL species with sphingomyelin (SM) and glycerophosphocholine between technical survival (n=15) and failure patients (n = 5). Cox regression showed SM 21:0 (adjusted HR 13.7, 95% CI 2.42-77.88, p = 0.003) was independently associated with patients technical failure.
  
  
  CONCLUSIONS
  PD failure patients had different plasma PLs profiling as compared with survival patients. Elevated plasma SM 21:0 level may potentially serve as a biomarker of PD patients at risk for adverse outcomes.
authors: Division of Nephrology, Peking University Third Hospital , Beijing , China and.
authors: Wen
authors: W
authors: Tang
authors: Min
authors: M
authors: Li
authors: Xin-Hong
authors: XH
authors: Lu
authors: Hu-Wei
authors: HW
authors: Liu
authors: Tao
authors: T
authors: Wang
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000401:mortality / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis; D010713:Phosphatidylcholines / Q000097:blood*; D016016:Proportional Hazards Models; D013109:Sphingomyelins / Q000097:blood*
chemical_list: D010713:Phosphatidylcholines; D013109:Sphingomyelins
keywords: Lipidomics; mass spectrometry; peritoneal dialysis; phospholipids; sphingomyelin