title: Effect of 5-HT(2A) receptor antagonists on blood flow in the carotid vessels upon elevation of serotonin level.
abstract: We studied the ability of predominantly 5-HT2A receptor antagonists to prevent a serotonin-induced change of blood flow in the carotid vessels of rats with experimental serotonin-induced spasm. Ritanserin, ketanserin, and 5-HT2A receptor antagonist RU-476 reduced the effect of serotonin on the blood fl ow velocity in the internal carotid artery by 2.3, 1.7, and 2.6 times, respectively.
authors: Volgograd State Medical University, Volgograd, Russia, dypharm@list.ru.
authors: D S
authors: DS
authors: Yakovlev
authors: A A
authors: AA
authors: Spasov
authors: D V
authors: DV
authors: Mal'tsev
authors: V A
authors: VA
authors: Anisimova
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D002339:Carotid Arteries / Q000187:drug effects* / Q000502:physiology; D004353:Drug Evaluation, Preclinical; D007650:Ketanserin / Q000494:pharmacology*; D008297:Male; D051381:Rats; D012039:Regional Blood Flow; D016713:Ritanserin / Q000494:pharmacology*; D012701:Serotonin / Q000502:physiology*; D058830:Serotonin 5-HT2 Receptor Antagonists / Q000494:pharmacology*; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D058830:Serotonin 5-HT2 Receptor Antagonists; D016713:Ritanserin; D012701:Serotonin; D007650:Ketanserin