title: [Genetic aspects of occupational chronic obstructive lung disease under exposure to various risk factors].
abstract: The article deals with data on association of SNP rs1828591 of HHIP gene with COLD development under exposure to dust and chemical factors. SNP rs1800470 of TGFbeta1 gene is associated with occupational COLD under exposure to dust and did not show connection with COLD under exposure to chemical aerosols. No association was seen between SNP rs4129267 of IL-6R gene and SNP rs1051730 of CHRNA3 gene with occupational COLD under exposure to the studied factors. SNP rs1828591 of HHIP gene is associated with occupational COLD development under exposure to dust and chemical factors. Study of association of genotype and phenotypic features of COLD revealed the following trends: "dust" COLD patients with genotype AA SNP rs1800470 of TGFbeta1 gene show lower level of C-reactive protein and TNF-alpha, if compared with other genotypes.
authors: L A
authors: LA
authors: Shpagina
authors: Mm I
authors: MI
authors: Voevoda
authors: O S
authors: OS
authors: Kotova
authors: V N
authors: VN
authors: Maksimov
authors: P S
authors: PS
authors: Orlov
authors: I S
authors: IS
authors: Shpagin
mesh_terms: D000328:Adult; D005838:Genotype; D006801:Humans; D009784:Occupational Diseases / Q000209:etiology / Q000235:genetics*; D016273:Occupational Exposure / Q000009:adverse effects*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D029424:Pulmonary Disease, Chronic Obstructive / Q000209:etiology / Q000235:genetics*; D012307:Risk Factors