title: Photo- and pH-tunable multicolor fluorescent nanoparticle-based spiropyran- and BODIPY-conjugated polymer with graphene oxide.
abstract: We report a stimuli-responsive fluorescent nanomaterial, based on graphene oxide coupled with a polymer conjugated with photochromic spiropyran (SP) dye and hydrophobic boron dipyrromethane (BODIPY) dye, for application in triggered target multicolor bioimaging. Graphene oxide (GO) was reduced by catechol-conjugated polymers under mildly alkaline conditions, which enabled to formation of functionalized multicolor graphene nanoparticles that can be induced by irradiation with UV light and by changing the pH from acidic to neutral. Investigation of these nanoparticles by using AFM, fluorescence emission, and in vitro cell and in vivo imaging revealed that they show different tunable colors in bioimaging applications and, more specifically, in cancer-cell detection. The stability, biocompatibility, and quenching efficacy of this nanocomposite open a different perspective for cell imaging in different independent colors, sequentially and simultaneously.
authors: Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701 (Republic of Korea).
authors: Shazid Md
authors: SM
authors: Sharker
authors: Chan Jin
authors: CJ
authors: Jeong
authors: Sung Min
authors: SM
authors: Kim
authors: Jung-Eun
authors: JE
authors: Lee
authors: Ji Hoon
authors: JH
authors: Jeong
authors: Insik
authors: I
authors: In
authors: Haeshin
authors: H
authors: Lee
authors: Sung Young
authors: SY
authors: Park
mesh_terms: D001578:Benzopyrans / Q000737:chemistry*; D001896:Boron Compounds / Q000737:chemistry*; D003116:Color; D005456:Fluorescent Dyes / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007211:Indoles / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D018613:Microscopy, Confocal; D053758:Nanoparticles; D009574:Nitro Compounds / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D013050:Spectrometry, Fluorescence
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D001578:Benzopyrans; D001896:Boron Compounds; D005456:Fluorescent Dyes; D007211:Indoles; D009574:Nitro Compounds; D010087:Oxides; D011108:Polymers; C088184:spiropyran; D006108:Graphite
keywords: UV sensitive; bioimaging; dyes/pigments; nanoparticles; pH sensitive