title: Poly(oligonucleotide).
abstract: Here we report the preparation of poly(oligonucleotide) brush polymers and amphiphilic brush copolymers from nucleic acid monomers via graft-through polymerization. We describe the polymerization of PNA-norbornyl monomers to yield poly-PNA (poly(peptide nucleic acid)) via ring-opening metathesis polymerization (ROMP) with the initiator, (IMesH2)(C5H5N)2(Cl)2RuCHPh.1 In addition, we present the preparation of poly-PNA nanoparticles from amphiphilic block copolymers and describe their hybridization to a complementary single-stranded DNA (ssDNA) oligonucleotide.
authors: Department of Chemistry and Biochemistry, University of California, San Diego , La Jolla, California 92093, United States.
authors: Carrie R
authors: CR
authors: James
authors: Anthony M
authors: AM
authors: Rush
authors: Thomas
authors: T
authors: Insley
authors: Lela
authors: L
authors: Vuković
authors: Lisa
authors: L
authors: Adamiak
authors: Petr
authors: P
authors: Král
authors: Nathan C
authors: NC
authors: Gianneschi
mesh_terms: D004247:DNA / Q000737:chemistry; D004277:DNA, Single-Stranded / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D053758:Nanoparticles / Q000737:chemistry; D009841:Oligonucleotides / Q000737:chemistry*; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D058105:Polymerization; D011108:Polymers / Q000737:chemistry
chemical_list: D004277:DNA, Single-Stranded; D009841:Oligonucleotides; D020135:Peptide Nucleic Acids; D011108:Polymers; D004247:DNA