title: Identification and replication of a combined epigenetic and genetic biomarker predicting suicide and suicidal behaviors.
abstract: Considerable research suggests that suicide involves effects of genes, the environment, and their interaction. Analysis of three independent data sets of post-mortem brains revealed signs of increased methylation in one particular gene, SKA2, a finding that was extended to peripheral blood samples from other cohorts of prospectively followed individuals.
authors: From the Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, and the Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore.
authors: Jerry
authors: J
authors: Guintivano
authors: Tori
authors: T
authors: Brown
authors: Alison
authors: A
authors: Newcomer
authors: Marcus
authors: M
authors: Jones
authors: Olivia
authors: O
authors: Cox
authors: Brion S
authors: BS
authors: Maher
authors: William W
authors: WW
authors: Eaton
authors: Jennifer L
authors: JL
authors: Payne
authors: Holly C
authors: HC
authors: Wilcox
authors: Zachary A
authors: ZA
authors: Kaminsky
mesh_terms: D000328:Adult; D000368:Aged; D001007:Anxiety / Q000235:genetics; D002102:Cadaver; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics*; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D005260:Female; D005786:Gene Expression Regulation; D005819:Genetic Markers; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D009457:Neuroglia / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D011237:Predictive Value of Tests; D017397:Prefrontal Cortex / Q000378:metabolism*; D012463:Saliva / Q000378:metabolism; D017422:Sequence Analysis, DNA; D013315:Stress, Psychological / Q000235:genetics*; D059020:Suicidal Ideation; D013405:Suicide; D013406:Suicide, Attempted
chemical_list: D002868:Chromosomal Proteins, Non-Histone; D005819:Genetic Markers; C516428:SKA2 protein, human; D006854:Hydrocortisone