title: The potential of adipokines as therapeutic agents for cardiovascular disease.
abstract: Adipose tissue functions as an endocrine organ by producing bioactive secretory proteins, also known as adipokines, that can directly act on nearby or remote organs. Most of the adipokines are upregulated by obese conditions, and typically promote obese complications. In contrast, some adipokines, such as adiponectin, CTRP9 and omentin, are downregulated in obese states. These factors exert salutary actions on obesity-linked cardiovascular disorders. In this review, we focus on the significance of adiponectin, CTRP9 and omentin as therapeutic agents for cardiovascular disease.
authors: Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan. Electronic address: rshibata@med.nagoya-u.ac.jp.
authors: Rei
authors: R
authors: Shibata
authors: Department of Molecular Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors: Koji
authors: K
authors: Ohashi
authors: Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors: Toyoaki
authors: T
authors: Murohara
authors: Department of Molecular Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan. Electronic address: nouchi@med.nagoya-u.ac.jp.
authors: Noriyuki
authors: N
authors: Ouchi
mesh_terms: D054392:Adipokines / Q000494:pharmacology* / Q000627:therapeutic use*; D052242:Adiponectin / Q000494:pharmacology; D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D002318:Cardiovascular Diseases / Q000188:drug therapy*; D016207:Cytokines / Q000494:pharmacology; D058851:GPI-Linked Proteins / Q000494:pharmacology; D006801:Humans; D037102:Lectins / Q000494:pharmacology; D051379:Mice; D009765:Obesity
chemical_list: D054392:Adipokines; D052242:Adiponectin; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins
keywords: Adipokines; Adiponectin; CTRP9; Cardiovascular disease; Omentin