title: Carpedilactones A-D, four new isomeric sesquiterpene lactone dimers with potent cytotoxicity from Carpesium faberi.
abstract: Four new isomeric sesquiterpene lactone dimers, carpedilactones A-D (1-4), were isolated from the acetonic extract of Carpesium faberi. Among them, 1-3 are the first three 2,4-linked exo-Diels-Alder adducts between a eudesmanolide dienophile and a guaianolide diene. The absolute configurations of 1-4 were unambiguously established by Cu Kα X-ray crystallographic analyses. Compounds 1-4 exhibited potent cytotoxicities against human leukemia (CCRF-CEM) cells with IC50 value of 0.14, 0.32, 0.35, and 0.16 μM, respectively.
authors: Department of Phytochemistry, School of Pharmacy, Second Military Medical University , Shanghai 200433, P. R. China.
authors: Yong-Xun
authors: YX
authors: Yang
authors: Lei
authors: L
authors: Shan
authors: Qing-Xin
authors: QX
authors: Liu
authors: Yun-Heng
authors: YH
authors: Shen
authors: Jian-Ping
authors: JP
authors: Zhang
authors: Ji
authors: J
authors: Ye
authors: Xi-Ke
authors: XK
authors: Xu
authors: Hui-Liang
authors: HL
authors: Li
authors: Wei-Dong
authors: WD
authors: Zhang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008968:Molecular Conformation; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes; C476916:eudesmanolide