title: Histological type-specific prognostic factors of cervical small cell neuroendocrine carcinoma, adenocarcinoma, and squamous cell carcinoma.
abstract: BACKGROUND
  The study aimed to determine the prognostic impact of clinical and pathological factors on survival among patients with small cell neuroendocrine carcinoma (SNEC), adenocarcinoma (ADC), and squamous cell carcinoma (SCC).
  
  
  METHODS
  Eligible participants were all patients with histologically confirmed cervical cancer treated at Chiang Mai University Hospital between 1995 and 2011. We included all patients with SNEC and randomly enrolled patients with ADC and SCC. We used competing-risk regression analysis to examine the risk of cancer-related death by histological type.
  
  
  RESULTS
  We included 130 (6.2%) women with SNEC, 346 (16.4%) with ADC, and 1,632 (77.4%) with SCC. Age >60 years (hazard ratio [HR] 4.9, 95% confidence interval [CI] 2.0-12.0) and lymph node involvement (HR 3.0, 95% CI 1.2-7.4) were prognostic factors among surgically-treated patients with SNEC. Deeper stromal invasion (HR 3.6, 95% CI 1.6-8.3) was a prognostic factor in patients with SCC. In patients with advanced SNEC, age >60 years had a strong prognostic impact (HR 2.6, 95% CI 1.0-6.5) while the International Federation of Gynecology and Obstetrics stages III and IV were prognostic factors for patients with advanced stage ADC (HR 2.9, 95% CI 2.0-4.4 and HR 4.5, 95% CI 2.6-7.9, respectively) and SCC (HR 1.7, 95% CI 1.4-2.0 and HR 3.7, 95% CI 2.8-4.9, respectively) compared with the International Federation of Gynecology and Obstetrics stage IIB.
  
  
  CONCLUSIONS
  Clinical and pathological prognostic factors in cervical cancer differed according to histological type. Taking the important prognostic factors for each histological type into consideration may be beneficial for tailored treatment and follow-up planning.
authors: Boromarajonani College of Nursing, KhonKaen, Thailand and Clinical Epidemiology Unit, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
authors: Suthida
authors: S
authors: Intaraphet
authors: Faculty of Nursing, Chiang Mai University, Chiang Mai, Thailand.
authors: Nongyao
authors: N
authors: Kasatpibal
authors: Department of Clinical Epidemiology, Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.
authors: Mette
authors: M
authors: Søgaard
authors: Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
authors: Surapan
authors: S
authors: Khunamornpong
authors: Clinical Research Center, Faculty of Medicine, Thammasat University, PathumThani, Thailand.
authors: Jayanton
authors: J
authors: Patumanond
authors: Department of Gynecology and Obstetrics, Nakornping Hospital, Chiang Mai, Thailand.
authors: Anchalee
authors: A
authors: Chandacham
authors: Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
authors: Imjai
authors: I
authors: Chitapanarux
authors: Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
authors: Sumalee
authors: S
authors: Siriaunkgul
keywords: cervical cancer; competing risk; histology; prognosis; prognostic factor; survival