title: GRP78 inhibits macrophage adhesion via SR-A.
abstract: Class A scavenger receptor (SR-A) plays an important role in macrophage adhesion. However, the underlying mechanism remains unclear. We previously found that 78 kDa glucose-regulated protein (GRP78) inhibited SR-A-mediated ligand internalization into macrophage by binding to SR-A. The aim of the study was to investigate whether GRP78 could regulate SR-A-mediated cell adhesion. We demonstrated that GRP78 bound directly to SR-A by fluorescence resonance energy transfer (FRET) assay. Overexpression of GRP78 inhibited macrophage adhesion via SR-A. These results suggest that GRP78 may act as an inhibitor of macrophage adhesion via SR-A.
authors: Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
authors: Hui
authors: H
authors: Bai
authors: Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
authors: Nan
authors: N
authors: Li
authors: Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
authors: Xiaodan
authors: X
authors: Zhou
authors: Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
authors: Chenchen
authors: C
authors: Wang
authors: Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
authors: Yan
authors: Y
authors: Zhang
authors: Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
authors: Xudong
authors: X
authors: Zhu
authors: Key Laboratory of Molecular and Medical Biotechnology, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
authors: Min
authors: M
authors: Huang
authors: Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
authors: Yaoyu
authors: Y
authors: Chen
authors: Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
authors: Xiaoyu
authors: X
authors: Li
authors: Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
authors: Qing
authors: Q
authors: Yang
authors: Key Laboratory of Molecular and Medical Biotechnology, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
authors: Chaojun
authors: C
authors: Li
authors: Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, Jiangsu 210029, China. ; State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
authors: Jingjing
authors: J
authors: Ben
authors: Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, Jiangsu 210029, China. ; State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
authors: Qi
authors: Q
authors: Chen
keywords: 6-aminonicotinamide; class A scavenger receptor; fluorescence resonance energy transfer; glucose-regulated protein 78 (GRP78); macrophage adhesion