title: Primaquine-induced severe methemoglobinemia developed during treatment of Plasmodium vivax malarial infection in an Indian family associated with a novel mutation (p.Agr57Trp) in the CYB5R3 gene.
authors: National Institute of Immunohematology, (Indian Council of Medical Research), 13th Floor, New Multistoried Building, K.E.M. Hospital Campus, Parel, Mumbai, India.
authors: Prabhakar
authors: P
authors: Kedar
authors: National Institute of Immunohematology, (Indian Council of Medical Research), 13th Floor, New Multistoried Building, K.E.M. Hospital Campus, Parel, Mumbai, India.
authors: Prashant
authors: P
authors: Warang
authors: Hiranandani Healthcare Pvt Limited, Vashi, Navi Mumbai 400703, India.
authors: Subhaprakash
authors: S
authors: Sanyal
authors: National Institute of Immunohematology, (Indian Council of Medical Research), 13th Floor, New Multistoried Building, K.E.M. Hospital Campus, Parel, Mumbai, India.
authors: Rati
authors: R
authors: Devendra
authors: National Institute of Immunohematology, (Indian Council of Medical Research), 13th Floor, New Multistoried Building, K.E.M. Hospital Campus, Parel, Mumbai, India.
authors: Kanjaksha
authors: K
authors: Ghosh
authors: National Institute of Immunohematology, (Indian Council of Medical Research), 13th Floor, New Multistoried Building, K.E.M. Hospital Campus, Parel, Mumbai, India. Electronic address: colahrb@gmail.com.
authors: Roshan
authors: R
authors: Colah
mesh_terms: D000293:Adolescent; D000328:Adult; D042966:Cytochrome-B(5) Reductase / Q000235:genetics*; D005260:Female; D006801:Humans; D007194:India; D016780:Malaria, Vivax / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D008708:Methemoglobinemia / Q000139:chemically induced / Q000175:diagnosis / Q000235:genetics*; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D010375:Pedigree; D011319:Primaquine / Q000009:adverse effects*; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: C583417:CYB5R3 protein, human; D042966:Cytochrome-B(5) Reductase; D011319:Primaquine
keywords: India; Methemoglobinemia; NADH-cytochrome b(5) reductase deficiency; Primaquine