title: Is hyperuricemia an independent risk factor for new-onset chronic kidney disease?: A systematic review and meta-analysis based on observational cohort studies.
abstract: BACKGROUND
  Hyperuricemia has been reported to be associated with chronic kidney disease (CKD). However whether an elevated serum uric acid level is an independent risk factor for new-onset CKD remained controversial.
  
  
  METHODS
  A systematic review and meta-analysis using a literature search of online databases including PubMed, Embase, Ovid and ISI Web/Web of Science was conducted. Summary adjusted odds ratios with corresponding 95% confidence intervals (95% CI) were calculated to evaluate the risk estimates of hyperuricemia for new-onset CKD.
  
  
  RESULTS
  Thirteen studies containing 190,718 participants were included. A significant positive association was found between elevated serum uric acid levels and new-onset CKD at follow-up (summary OR, 1.15; 95% CI, 1.05-1.25). Hyperuricemia was found be an independent predictor for the development of newly diagnosed CKD in non-CKD patients (summary OR, 2.35; 95% CI, 1.59-3.46). This association increased with increasing length of follow-up. No significant differences were found for risk estimates of the associations between elevated serum uric acid levels and developing CKD between males and females.
  
  
  CONCLUSIONS
  With long-term follow-up of non-CKD individuals, elevated serum uric acid levels showed an increased risk for the development of chronic renal dysfunction.
authors: Ling
authors: L
authors: Li
authors: Chen
authors: C
authors: Yang
authors: Yuliang
authors: Y
authors: Zhao
authors: Xiaoxi
authors: X
authors: Zeng
authors: Fang
authors: F
authors: Liu
authors: Division of Nephrology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China. fupinghx@163.com.
authors: Ping
authors: P
authors: Fu
mesh_terms: D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D033461:Hyperuricemia / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology*; D008297:Male; D064887:Observational Studies as Topic; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology*; D012307:Risk Factors