title: microRNA-203: Tumor Suppression and Beyond.
abstract: The involvement of microRNAs in human cancer is now well established. A few miRNAs function as oncogenes and many others display tumor suppressor activities. Several studies in the past few years have highlighted and reinforced a role for miR-203 as a tumor suppressor microRNA. This collection of in vitro studies give an initial and stimulating look into the many different means by which miR-203 can inhibit the various pathways involved in cell transformation and metastasis. Of special relevance is the ability of miR-203 to prevent proliferation of progenitor cells as well the epithelial-to-mesenchymal transition frequently associated with cancer progression and metastasis. Further more, the breadth of cancer types examined in these studies implicates miR-203 as a potential tumor suppressor gene whose re-expression or re-introduction into malignant cells could, by nature of its inherent pleiotropic effects as a miRNA, represent an important therapeutic tool used to combat a multitude of human cancers.
authors: Carlos I
authors: CI
authors: Michel
authors: Centro Nacional de Investigaciones Oncológicas (CNIO), Melchor Fernández Almagro 3, E-28029 Madrid, Spain. mmm@cnio.es.
authors: Marcos
authors: M
authors: Malumbres
mesh_terms: D045744:Cell Line, Tumor; D058750:Epithelial-Mesenchymal Transition; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D006801:Humans; D035683:MicroRNAs; D009369:Neoplasms
chemical_list: D035683:MicroRNAs