title: Macrophages in the liver prevent metastasis by efficiently eliminating circulating tumor cells after monoclonal antibody immunotherapy.
abstract: Monoclonal antibodies (mAbs) are increasingly being used to treat cancer. In response to mAb therapy, we have identified macrophages in the liver as major effector cells removing circulating tumor cells via antibody-dependent phagocytosis, an immune cell-mediated process that prevented liver metastasis. This discovery extends our understanding of the mechanisms of mAb therapy, and may help to optimize mAb-based anticancer therapeutics.
authors: Department of Molecular Cell Biology and Immunology; VU University Medical Center; Amsterdam, The Netherlands.
authors: Nuray
authors: N
authors: Gül
authors: Immunology Research Group; University of Calgary; Calgary, Canada.
authors: Liane
authors: L
authors: Babes
authors: Immunology Research Group; University of Calgary; Calgary, Canada.
authors: Paul
authors: P
authors: Kubes
authors: Department of Molecular Cell Biology and Immunology; VU University Medical Center; Amsterdam, The Netherlands ; Department of Surgery; VU University Medical Center; Amsterdam, The Netherlands.
authors: Marjolein
authors: M
authors: van Egmond
keywords: Fc receptors; Kupffer cells; antibody-dependent cellular phagocytosis; liver metastasis; mAbs