title: The serotonin 6 receptor controls neuronal migration during corticogenesis via a ligand-independent Cdk5-dependent mechanism.
abstract: The formation of a laminar structure such as the mammalian neocortex relies on the coordinated migration of different subtypes of excitatory pyramidal neurons in specific layers. Cyclin-dependent kinase 5 (Cdk5) is a master regulator of pyramidal neuron migration. Recently, we have shown that Cdk5 binds to the serotonin 6 receptor (5-HT6R), a G protein-coupled receptor (GPCR). Here, we investigated the role of 5-HT6R in the positioning and migration of pyramidal neurons during mouse corticogenesis. We report that constitutive expression of 5-HT6R controls pyramidal neuron migration through an agonist-independent mechanism that requires Cdk5 activity. These data provide the first in vivo evidence of a role for constitutive activity at a GPCR in neocortical radial migration.
authors: Department of Psychiatry, University of Geneva Medical School, CH-1211 Geneva 4, Switzerland Department of Basic Neurosciences, University of Geneva Medical School, CH-1211 Geneva 4, Switzerland.
authors: Moritz
authors: M
authors: Jacobshagen
authors: Department of Psychiatry, University of Geneva Medical School, CH-1211 Geneva 4, Switzerland Department of Basic Neurosciences, University of Geneva Medical School, CH-1211 Geneva 4, Switzerland.
authors: Mathieu
authors: M
authors: Niquille
authors: Institut de Génomique Fonctionnelle, CNRS UMR 5203, INSERM U661, Universités Montpellier I & II, Montpellier 34094, France.
authors: Séverine
authors: S
authors: Chaumont-Dubel
authors: Institut de Génomique Fonctionnelle, CNRS UMR 5203, INSERM U661, Universités Montpellier I & II, Montpellier 34094, France.
authors: Philippe
authors: P
authors: Marin
authors: Department of Psychiatry, University of Geneva Medical School, CH-1211 Geneva 4, Switzerland Department of Basic Neurosciences, University of Geneva Medical School, CH-1211 Geneva 4, Switzerland alexandre.dayer@unige.ch.
authors: Alexandre
authors: A
authors: Dayer
mesh_terms: D000818:Animals; D002465:Cell Movement; D002540:Cerebral Cortex / Q000166:cytology* / Q000378:metabolism; D051360:Cyclin-Dependent Kinase 5 / Q000378:metabolism*; D015536:Down-Regulation; D005260:Female; D057809:HEK293 Cells; D006801:Humans; D008024:Ligands; D051379:Mice; D008810:Mice, Inbred C57BL; D055495:Neurogenesis; D009474:Neurons / Q000166:cytology* / Q000378:metabolism*; D017966:Pyramidal Cells / Q000166:cytology / Q000378:metabolism; D011985:Receptors, Serotonin / Q000235:genetics / Q000378:metabolism*; D013379:Substrate Specificity
chemical_list: D008024:Ligands; D011985:Receptors, Serotonin; C097216:serotonin 6 receptor; D051360:Cyclin-Dependent Kinase 5
keywords: 5-HT6 receptor; Cdk5; Cortex; Migration; Mouse; Serotonin