title: Decreased proliferation ability and differentiation potential of mesenchymal stem cells of osteoporosis rat.
abstract: OBJECTIVE
  To explore decreased proliferation ability and differentiation potential of mesenchymal stem cells (MSCs) of osteoporosis rat.
  
  
  METHODS
  MSCs were obtained from osteoporosis rat, and proliferation potency and impaired osteogenic differentiation potential were determined.
  
  
  RESULTS
  The result showed a significant downregulation of MSCs pluripotency related gene (Oct 4) and osteogenic genes (BSP, OCN) expression in OVX MSCs compared with Sham MSCs (P<0.05).
  
  
  CONCLUSIONS
  These data suggest that MSCs are aging in osteoporosis body, and autologous OVX MSCs transplantation is not appropriate to treat osteoporosis if necessary. There will be a possibility in establishing a new clinical application of MSCs autologous transplantation to treat osteoporosis, if OVX MSCs have stronger proliferation and differentiation.
authors: 2nd Department of Orthopaedic Surgery, No. 2 Affiliated Hospital of Harbin Medical University, Heilongjiang Province 150086, China.
authors: Qiang
authors: Q
authors: Wang
authors: 2nd Department of Orthopaedic Surgery, No. 2 Affiliated Hospital of Harbin Medical University, Heilongjiang Province 150086, China.
authors: Bing
authors: B
authors: Zhao
authors: 2nd Department of Orthopaedic Surgery, No. 2 Affiliated Hospital of Harbin Medical University, Heilongjiang Province 150086, China.
authors: Chao
authors: C
authors: Li
authors: 2nd Department of Orthopaedic Surgery, No. 2 Affiliated Hospital of Harbin Medical University, Heilongjiang Province 150086, China.
authors: Jie-Sheng
authors: JS
authors: Rong
authors: 2nd Department of Orthopaedic Surgery, No. 2 Affiliated Hospital of Harbin Medical University, Heilongjiang Province 150086, China.
authors: Shu-Qing
authors: SQ
authors: Tao
authors: 2nd Department of Orthopaedic Surgery, No. 2 Affiliated Hospital of Harbin Medical University, Heilongjiang Province 150086, China. Electronic address: taotianzunttz@hotmail.com.
authors: Tian-Zun
authors: TZ
authors: Tao
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D049109:Cell Proliferation / Q000502:physiology*; D004195:Disease Models, Animal; D005260:Female; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology*; D010024:Osteoporosis / Q000503:physiopathology*; D010052:Ovariectomy; D051381:Rats; D017207:Rats, Sprague-Dawley
keywords: Differentiation; Mesenchymal stem cells; Osteoporosis; Proliferation