title: The cellular mastermind(?)-mechanotransduction and the nucleus.
abstract: Cells respond to mechanical stimulation by activation of specific signaling pathways and genes that allow the cell to adapt to its dynamic physical environment. How cells sense the various mechanical inputs and translate them into biochemical signals remains an area of active investigation. Recent reports suggest that the cell nucleus may be directly implicated in this cellular mechanotransduction process. Taken together, these findings paint a picture of the nucleus as a central hub in cellular mechanotransduction-both structurally and biochemically-with important implications in physiology and disease.
authors: Department of Biomedical Engineering & Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York, USA.
authors: Ashley
authors: A
authors: Kaminski
authors: Department of Biomedical Engineering & Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York, USA.
authors: Gregory R
authors: GR
authors: Fedorchak
authors: Department of Biomedical Engineering & Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York, USA.
authors: Jan
authors: J
authors: Lammerding
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D022003:Cell Nucleus Structures / Q000378:metabolism; D004194:Disease; D006801:Humans; D040542:Mechanotransduction, Cellular
keywords: Forces; LINC complex; Lamins; Mechanics; Signaling