title: [Regulation of Yersinia pseudotuberculosis major porin expression in response to antibiotic stress].
abstract: The OmpF porin gene expression in Yersinia pseudotuberculosis in response to antibiotics of two different classes (kanamycin and nalidixic acid) was analyzed using quantitative PCR and a fluorescence reporter system. Both antibiotics downregulated the expression of the ompF gene. The nalidixic acid significantly reduced ompF expression, while kanamycin, for which porins are considered to be an alternative transport route, only slightly reduced the ompF level.
authors: E P
authors: EP
authors: Bystritskaia
authors: A M
authors: AM
authors: Stenkova
authors: O Iu
authors: OIu
authors: Portniagina
authors: A V
authors: AV
authors: Rakin
authors: V A
authors: VA
authors: Rasskazov
authors: M P
authors: MP
authors: Isaeva
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001425:Bacterial Outer Membrane Proteins / Q000096:biosynthesis* / Q000235:genetics; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects* / Q000235:genetics; D007612:Kanamycin / Q000494:pharmacology*; D009268:Nalidixic Acid / Q000494:pharmacology*; D016133:Polymerase Chain Reaction; D018272:Porins / Q000096:biosynthesis* / Q000235:genetics; D013312:Stress, Physiological / Q000187:drug effects* / Q000235:genetics; D015011:Yersinia pseudotuberculosis / Q000235:genetics / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001425:Bacterial Outer Membrane Proteins; C109237:OmpF protein; D018272:Porins; D009268:Nalidixic Acid; D007612:Kanamycin