title: Reconstruction of fluorophore concentration variation in dynamic fluorescence molecular tomography.
abstract: Dynamic fluorescence molecular tomography (DFMT) is a potential approach for drug delivery, tumor detection, diagnosis, and staging. The purpose of DFMT is to quantify the changes of fluorescent agents in the bodies, which offer important information about the underlying physiological processes. However, the conventional method requires that the fluorophore concentrations to be reconstructed are stationary during the data collection period. As thus, it cannot offer the dynamic information of fluorophore concentration variation within the data collection period. In this paper, a method is proposed to reconstruct the fluorophore concentration variation instead of the fluorophore concentration through a linear approximation. The fluorophore concentration variation rate is introduced by the linear approximation as a new unknown term to be reconstructed and is used to obtain the time courses of fluorophore concentration. Simulation and phantom studies are performed to validate the proposed method. The results show that the method is able to reconstruct the fluorophore concentration variation rates and the time courses of fluorophore concentration with relative errors less than 0.0218.
authors: Xuanxuan
authors: X
authors: Zhang
authors: Fei
authors: F
authors: Liu
authors: Simin
authors: S
authors: Zuo
authors: Junwei
authors: J
authors: Shi
authors: Guanglei
authors: G
authors: Zhang
authors: Jing
authors: J
authors: Bai
authors: Jianwen
authors: J
authors: Luo
mesh_terms: D005456:Fluorescent Dyes / Q000032:analysis / Q000378:metabolism*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008856:Microscopy, Fluorescence / Q000379:methods*; D008954:Models, Biological; D015233:Models, Statistical; D057054:Molecular Imaging / Q000379:methods*; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013050:Spectrometry, Fluorescence / Q000379:methods; D041622:Tomography, Optical / Q000379:methods*
chemical_list: D005456:Fluorescent Dyes