title: The diagnostic value of cervical lymph node metastasis in head and neck squamous carcinoma by using diffusion-weighted magnetic resonance imaging and computed tomography perfusion.
abstract: OBJECTIVE
  The aim of this study was to compare diffusion-weighted magnetic resonance imaging (DWI) with computed tomography perfusion (CTP) for preoperative detection of metastases to lymph nodes (LNs) in head and neck squamous cell carcinoma (SCC).
  
  
  METHODS
  Between May 2010 and April 2012, 30 patients with head and neck SCC underwent preoperative DWI and CTP. Two radiologists measured apparent diffusion coefficient (ADC) values and CTP parameters independently. Surgery and histopathologic examinations were performed on all patients.
  
  
  RESULTS
  On DWI, 65 LNs were detected in 30 patients. The mean ADC value of metastatic nodes was lower than benign nodes and the difference was statistically significant (P < 0.05). On CTP images, the mean value in metastatic nodes of blood flow (BF) and blood volume (BV) was higher than that in benign nodes, and mean transit time (MTT) in metastatic nodes was lower than that in benign nodes. There were significant differences in BF and MTT values between metastatic and benign LNs (P < 0.05). There were significant differences between the AUCs of DWI and CTP (Z=4.612, P < 0.001).
  
  
  CONCLUSIONS
  DWI with ADC value measurements may be more accurate than CTP for the preoperative diagnosis of cervical LN metastases.
authors: Department of Imaging, Tianjin Union Medicine Centre, Tianjin 300121, China.
authors: Jin
authors: J
authors: Zhong
authors: Department of Imaging, Tianjin Union Medicine Centre, Tianjin 300121, China.
authors: Zonghong
authors: Z
authors: Lu
authors: Department of Imaging, Tianjin Union Medicine Centre, Tianjin 300121, China.
authors: Liang
authors: L
authors: Xu
authors: Department of Imaging, Tianjin Union Medicine Centre, Tianjin 300121, China.
authors: Longchun
authors: L
authors: Dong
authors: Department of Imaging, Tianjin Union Medicine Centre, Tianjin 300121, China.
authors: Hui
authors: H
authors: Qiao
authors: Department of Imaging, Tianjin Union Medicine Centre, Tianjin 300121, China.
authors: Rui
authors: R
authors: Hua
authors: Department of Imaging, Tianjin Union Medicine Centre, Tianjin 300121, China.
authors: Yi
authors: Y
authors: Gong
authors: Department of Imaging, Tianjin Union Medicine Centre, Tianjin 300121, China.
authors: Zhenxing
authors: Z
authors: Liu
authors: Department of Imaging, Tianjin Union Medicine Centre, Tianjin 300121, China.
authors: Caixian
authors: C
authors: Hao
authors: Department of Imaging, Tianjin Union Medicine Centre, Tianjin 300121, China.
authors: Xuehuan
authors: X
authors: Liu
authors: Department of Imaging, Tianjin Union Medicine Centre, Tianjin 300121, China.
authors: Changqing
authors: C
authors: Zong
authors: Department of Imaging, Tianjin Union Medicine Centre, Tianjin 300121, China.
authors: Li
authors: L
authors: He
authors: Department of Imaging, Tianjin Union Medicine Centre, Tianjin 300121, China.
authors: Jun
authors: J
authors: Liu
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging*; D002574:Cervical Vertebrae / Q000000981:diagnostic imaging* / Q000473:pathology; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging*; D006801:Humans; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D010477:Perfusion; D000077195:Squamous Cell Carcinoma of Head and Neck; D014057:Tomography, X-Ray Computed