title: Microwave-assisted cobinamide synthesis.
abstract: We present a new method for the preparation of cobinamide (CN)2Cbi, a vitamin B12 precursor, that should allow its broader utility. Treatment of vitamin B12 with only NaCN and heating in a microwave reactor affords (CN)2Cbi as the sole product. The purification procedure was greatly simplified, allowing for easy isolation of the product in 94% yield. The use of microwave heating proved beneficial also for (CN)2Cbi(c-lactone) synthesis. Treatment of (CN)2Cbi with triethanolamine led to (CN)2Cbi(c-lactam).
authors: Institute of Organic Chemistry, Polish Academy of Science , Kasprzaka 44/52, 01-224 Warsaw, Poland.
authors: Keith
authors: K
authors: O Proinsias
authors: Maksymilian
authors: M
authors: Karczewski
authors: Anna
authors: A
authors: Zieleniewska
authors: Dorota
authors: D
authors: Gryko
mesh_terms: D003038:Cobamides / Q000138:chemical synthesis* / Q000737:chemistry; D004983:Ethanolamines / Q000737:chemistry*; D047029:Lactams, Macrocyclic / Q000138:chemical synthesis* / Q000737:chemistry; D008872:Microwaves; D014805:Vitamin B 12 / Q000737:chemistry*
chemical_list: D003038:Cobamides; D004983:Ethanolamines; D047029:Lactams, Macrocyclic; C017142:cobinamide; C009546:triethanolamine; D014805:Vitamin B 12