title: Therapeutic potential and pharmacological activities of Atractylodes lancea (Thunb.) DC.
abstract: The rhizome of Atractylodes lancea (A. lancea) (Thunb.) DC. (AL) is extensively used in Chinese, Thai, and Japanese traditional medicines as crude extracts/decoctions or a component in various herbal formulations. Various pharmacological activities of AL and its major constituents have been demonstrated in vitro, ex vivo, and in animal models. Results from the toxicity studies in animal models suggest safety profile of AL and its active constituents. Despite extensive use with positive impression in many diseases, there has not been a clinical study that can conclusively support its efficacy and safety profile in human. This review comprehensively summarizes current information on the pharmacological activities of AL and their active constituents including anticancer, anti-inflammatory, antimicrobial and antipyretic activities, as well as activities on central nervous, cardiovascular, and gastrointestinal systems.
authors: Department of Clinical Product Development, Institute of Tropical Medicine, Nagasaki University, Japan.
authors: Nut
authors: N
authors: Koonrungsesomboon
authors: Graduate Program in Bioclinical Sciences, Chulabhorn International College of Medicine, Thammasat University, Thailand.
authors: Kesara
authors: K
authors: Na-Bangchang
authors: Department of Clinical Product Development, Institute of Tropical Medicine, Nagasaki University, Japan. Electronic address: karbwangj@nagasaki-u.ac.jp.
authors: Juntra
authors: J
authors: Karbwang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents; D031174:Atractylodes / Q000737:chemistry*; D002317:Cardiovascular Agents; D002460:Cell Line; D005765:Gastrointestinal Agents; D006801:Humans; D008518:Medicine, East Asian Traditional; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D027343:Rhizome / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D002317:Cardiovascular Agents; D005765:Gastrointestinal Agents; D010936:Plant Extracts
keywords: Atractylodes lancea; Herb; Pharmacological activities; Traditional medicine