title: Identification of structural variation in mouse genomes.
abstract: Structural variation is variation in structure of DNA regions affecting DNA sequence length and/or orientation. It generally includes deletions, insertions, copy-number gains, inversions, and transposable elements. Traditionally, the identification of structural variation in genomes has been challenging. However, with the recent advances in high-throughput DNA sequencing and paired-end mapping (PEM) methods, the ability to identify structural variation and their respective association to human diseases has improved considerably. In this review, we describe our current knowledge of structural variation in the mouse, one of the prime model systems for studying human diseases and mammalian biology. We further present the evolutionary implications of structural variation on transposable elements. We conclude with future directions on the study of structural variation in mouse genomes that will increase our understanding of molecular architecture and functional consequences of structural variation.
authors: Wellcome Trust Sanger Institute Hinxton, Cambridge, UK.
authors: Thomas M
authors: TM
authors: Keane
authors: Wellcome Trust Sanger Institute Hinxton, Cambridge, UK.
authors: Kim
authors: K
authors: Wong
authors: Wellcome Trust Sanger Institute Hinxton, Cambridge, UK.
authors: David J
authors: DJ
authors: Adams
authors: Wellcome Trust Centre for Human Genetics Oxford, UK.
authors: Jonathan
authors: J
authors: Flint
authors: Center for Integrative Genomics, University of Lausanne Lausanne, Switzerland.
authors: Alexandre
authors: A
authors: Reymond
authors: Center for Integrative Genomics, University of Lausanne Lausanne, Switzerland ; Institute of Genetics and Molecular and Cellular Biology Illkirch, France.
authors: Binnaz
authors: B
authors: Yalcin
keywords: Heterogeneous Stock (HS); Sanger Mouse Genomes Project; array comparative genome hybridization (aCGH); inbred strains of mice; next-generation sequencing (NGS); paired-end mapping (PEM); structural variation (SV)