title: Use of magnetic resonance imaging to monitor iron overload.
abstract: Treatment of iron overload requires robust estimates of total-body iron burden and its response to iron chelation therapy. Compliance with chelation therapy varies considerably among patients, and individual reporting is notoriously unreliable. Even with perfect compliance, intersubject variability in chelator effectiveness is extremely high, necessitating reliable iron estimates to guide dose titration. In addition, each chelator has a unique profile with respect to clearing iron stores from different organs. This article presents the tools available to clinicians to monitor their patients, focusing on noninvasive magnetic resonance imaging methods because they have become the de facto standard of care.
authors: Department of Pediatrics, Children's Hospital, Los Angeles, Keck School of Medicine, University of Southern California, 4650 Sunset Boulevard, Los Angeles, CA 90027, USA; Department of Radiology, Children's Hospital, Los Angeles, Keck School of Medicine, University of Southern California, 4650 Sunset Boulevard, Los Angeles, CA 90027, USA. Electronic address: jwood@chla.usc.edu.
authors: John C
authors: JC
authors: Wood
mesh_terms: D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000378:metabolism; D019190:Iron Overload / Q000097:blood / Q000175:diagnosis* / Q000378:metabolism; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008279:Magnetic Resonance Imaging; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D010179:Pancreas / Q000378:metabolism / Q000473:pathology; D013154:Spleen / Q000378:metabolism / Q000473:pathology
chemical_list: D015415:Biomarkers; D007501:Iron
keywords: Chelation; Heart; Iron; Iron overload; Liver; Magnetic resonance imaging; Sickle cell disease; Thalassemia