title: The effect of various cold-water immersion protocols on exercise-induced inflammatory response and functional recovery from high-intensity sprint exercise.
abstract: OBJECTIVE
  The purpose of this study was to investigate the effects of different cold-water immersion (CWI) protocols on the inflammatory response to and functional recovery from high-intensity exercise.
  
  
  METHODS
  Eight healthy recreationally active males completed five trials of a high-intensity intermittent sprint protocol followed by a randomly assigned recovery condition: 1 of 4 CWI protocols (CWI-10 min × 20 °C, CWI-30 min × 20 °C, CWI-10 min × 10 °C, or CWI-30 min × 10 °C) versus passive rest. Circulating mediators of the inflammatory response were measured from EDTA plasma taken pre-exercise (baseline), immediately post-exercise, and at 2, 24, and 48 h post-exercise. Ratings of perceived soreness and impairment were noted on a 10-pt Likert scale, and squat jump and drop jump were performed at these time points.
  
  
  RESULTS
  IL-6, IL-8, and MPO increased significantly from baseline immediately post-exercise in all conditions. IL-6 remained elevated from baseline at 2 h in the CWI-30 min × 20 °C, CWI-10 min × 10 °C, and CWI-30 min × 10 °C conditions, while further increases were observed for IL-8 and MPO in the CWI-30 min × 20 °C and CWI-30 min × 10 °C conditions. Squat jump and drop jump height were significantly lower in all conditions immediately post-exercise and at 2 h. Drop jump remained below baseline at 24 and 48 h in the CON and CWI-10 min × 20 °C conditions only, while squat jump height returned to baseline in all conditions.
  
  
  CONCLUSIONS
  Cold-water immersion appears to facilitate restoration of muscle performance in a stretch-shortening cycle, but not concentric power. These changes do not appear to be related to inflammatory modulation. CWI protocols of excessive duration may actually exacerbate the concentration of cytokines in circulation post-exercise; however, the origin of the circulating cytokines is not necessarily skeletal muscle.
authors: Graduate Department of Exercise Sciences, University of Toronto, BN 60, 55 Harbord St., Toronto, ON, M5S 2W6, Canada, gillian.white@mail.utoronto.ca.
authors: Gillian E
authors: GE
authors: White
authors: Shawn G
authors: SG
authors: Rhind
authors: Greg D
authors: GD
authors: Wells
mesh_terms: D000328:Adult; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D007101:Immersion; D007249:Inflammation / Q000209:etiology / Q000517:prevention & control; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D009195:Peroxidase / Q000097:blood; D020127:Recovery of Function; D012420:Running; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014867:Water
chemical_list: D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D014867:Water; D009195:Peroxidase