title: Indimicins A-E, Bisindole Alkaloids from the Deep-Sea-Derived Streptomyces sp. SCSIO 03032.
abstract: Five new bisindole alkaloids, indimicins A-E (1-5), bearing a unique 1',3'-dimethyl-2'-hydroindole moiety, were isolated from the marine-derived Streptomyces sp. SCSIO 03032, along with two new compounds, lynamicins F and G (6 and 7). Their planar structures were elucidated by detailed interpretation of their MS and NMR spectroscopic data, and the absolute configurations were determined by X-ray crystallographic analysis (for 1), comparison of CD spectra (for 2-4), and quantum chemical calculations (for 5). Indimicin B (2) exhibited moderate cytotoxic activity toward the MCF-7 cell line.
authors: CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, Collaborative Innovation Center of Deep Sea Biology, South China Sea Institute of Oceanology, Chinese Academy of Sciences , 164 West Xingang Road, Guangzhou 510301, People's Republic of China.
authors: Wenjun
authors: W
authors: Zhang
authors: CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, Collaborative Innovation Center of Deep Sea Biology, South China Sea Institute of Oceanology, Chinese Academy of Sciences , 164 West Xingang Road, Guangzhou 510301, People's Republic of China.
authors: Liang
authors: L
authors: Ma
authors: CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, Collaborative Innovation Center of Deep Sea Biology, South China Sea Institute of Oceanology, Chinese Academy of Sciences , 164 West Xingang Road, Guangzhou 510301, People's Republic of China.
authors: Sumei
authors: S
authors: Li
authors: Guangzhoujinan Biomedicine Research and Development Center, Guangdong Key Laboratory of Bioengineering Medicine, Jinan University , 601 West Huangpu Road, Guangzhou 510632, People's Republic of China.
authors: Zhong
authors: Z
authors: Liu
authors: Guangdong Institute of Microbiology , 100 Central Xianlie Road, Guangzhou 510070, People's Republic of China.
authors: Yuchan
authors: Y
authors: Chen
authors: CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, Collaborative Innovation Center of Deep Sea Biology, South China Sea Institute of Oceanology, Chinese Academy of Sciences , 164 West Xingang Road, Guangzhou 510301, People's Republic of China.
authors: Haibo
authors: H
authors: Zhang
authors: CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, Collaborative Innovation Center of Deep Sea Biology, South China Sea Institute of Oceanology, Chinese Academy of Sciences , 164 West Xingang Road, Guangzhou 510301, People's Republic of China.
authors: Guangtao
authors: G
authors: Zhang
authors: CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, Collaborative Innovation Center of Deep Sea Biology, South China Sea Institute of Oceanology, Chinese Academy of Sciences , 164 West Xingang Road, Guangzhou 510301, People's Republic of China.
authors: Qingbo
authors: Q
authors: Zhang
authors: CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, Collaborative Innovation Center of Deep Sea Biology, South China Sea Institute of Oceanology, Chinese Academy of Sciences , 164 West Xingang Road, Guangzhou 510301, People's Republic of China.
authors: Xinpeng
authors: X
authors: Tian
authors: CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, Collaborative Innovation Center of Deep Sea Biology, South China Sea Institute of Oceanology, Chinese Academy of Sciences , 164 West Xingang Road, Guangzhou 510301, People's Republic of China.
authors: Chengshan
authors: C
authors: Yuan
authors: CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, Collaborative Innovation Center of Deep Sea Biology, South China Sea Institute of Oceanology, Chinese Academy of Sciences , 164 West Xingang Road, Guangzhou 510301, People's Republic of China.
authors: Si
authors: S
authors: Zhang
authors: Guangdong Institute of Microbiology , 100 Central Xianlie Road, Guangzhou 510070, People's Republic of China.
authors: Weimin
authors: W
authors: Zhang
authors: CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, Collaborative Innovation Center of Deep Sea Biology, South China Sea Institute of Oceanology, Chinese Academy of Sciences , 164 West Xingang Road, Guangzhou 510301, People's Republic of China.
authors: Changsheng
authors: C
authors: Zhang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D008386:Marine Biology; D008968:Molecular Conformation; D015394:Molecular Structure; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D026121:Indole Alkaloids; C000601982:indimicin B; C000601983:lynamicin F; C000601984:lynamicin G