title: Increased visibility of deep medullary veins in leukoaraiosis: a 3-T MRI study.
abstract: Cerebral venous collagenosis has been implicated in leading to white matter hyperintensities (WMHs) via venous ischemia. We sought to determine whether cerebral venous dilation or ischemia correlate with the severity of WMHs by quantitative in vivo imaging techniques. This was an investigator-initiated prospective single-center study. We reviewed clinical, laboratory data from 158 consecutive WMHs patients and 50 controls, and measured the number of voxels of deep medullary veins (DMVs) on susceptibility-weighted image and assessed the WMH volume (as a marker of the severity of WMHs) on a 3-T magnetic resonance system. We then performed the logistic-regression analysis and partial Pearson's correlation analysis to examine the association between the venous voxel count and WMH volume. The number of voxels of DMVs was significantly higher in WMHs than in controls. Increased number of voxels of DMVs was independently associated with both WMH volume of the whole brain and coregistered regional WMH volume after adjusting for age and number of lacunes. Our study indicates that cerebral deep venous insufficiency or ischemia play a role in the pathogenesis of WMHs, which may provide prognostic information on patients with WMHs and may have implications for therapeutic interventions.
authors: Department of Neurology, The Second Affiliated Hospital of Zhejiang University, School of Medicine , Hangzhou , China.
authors: Shenqiang
authors: S
authors: Yan
authors: Department of Neurology, The Second Affiliated Hospital of Zhejiang University, School of Medicine , Hangzhou , China.
authors: Jinping
authors: J
authors: Wan
authors: Department of Neurology, The Second Affiliated Hospital of Zhejiang University, School of Medicine , Hangzhou , China.
authors: Xuting
authors: X
authors: Zhang
authors: Department of Neurology, The Second Affiliated Hospital of Zhejiang University, School of Medicine , Hangzhou , China.
authors: Lusha
authors: L
authors: Tong
authors: Department of Radiology, The Second Affiliated Hospital of Zhejiang University, School of Medicine , Hangzhou , China.
authors: Song
authors: S
authors: Zhao
authors: Department of Radiology, The Second Affiliated Hospital of Zhejiang University, School of Medicine , Hangzhou , China.
authors: Jianzhong
authors: J
authors: Sun
authors: Department of Neurology, The Second Affiliated Hospital of Zhejiang University, School of Medicine , Hangzhou , China.
authors: Yuehan
authors: Y
authors: Lin
authors: Department of Neurology, The Second Affiliated Hospital of Zhejiang University, School of Medicine , Hangzhou , China.
authors: Chunhong
authors: C
authors: Shen
authors: Department of Neurology, The Second Affiliated Hospital of Zhejiang University, School of Medicine , Hangzhou , China.
authors: Min
authors: M
authors: Lou
keywords: aging; deep medullary veins; leukoaraiosis; susceptibility-weighted imaging; venous ischemia; white matter hyperintensities