title: KLRG1+natural killer cells protect against pulmonary metastatic disease by immunosurveillance.
abstract: Natural killer cells (NK cells) play a key role in cancer immunosurveillance. However, their activity is highly dependent upon their maturation stage, which in turn relates to organ distribution. Here, we discuss the role of intrinsic master transcription factors and extrinsic IL-15 signaling on NK cell-mediated immune protection against murine pulmonary metastasis.
authors: Department of Surgery; University Hospital Regensburg; University of Regensburg; Regensburg, Germany.
authors: Philipp
authors: P
authors: Renner
authors: Department of Nephrology and Renal Transplantation; Hospital Clinic de Barcelona; Barcelona, Spain.
authors: Jordi
authors: J
authors: Rovira
authors: Experimental Medicine and Therapy Research; University of Regensburg; Regensburg, Germany.
authors: Christoph
authors: C
authors: Klein
authors: Department of Surgery; University Hospital Regensburg; University of Regensburg; Regensburg, Germany.
authors: Hans-Jürgen
authors: HJ
authors: Schlitt
authors: Department of Surgery; University Hospital Regensburg; University of Regensburg; Regensburg, Germany.
authors: Edward K
authors: EK
authors: Geissler
authors: Department of Surgery; University Hospital Regensburg; University of Regensburg; Regensburg, Germany.
authors: Alexander
authors: A
authors: Kroemer
keywords: Eomes; IL-15; KLRG1; NK cells; T-bet; immunosurveillance; metastasis