title: Serum nesfatin-1 levels in overt and subclinical hyperthyroidism.
abstract: OBJECTIVE
  Nesfatin-1 was recently discovered anorexigenic peptide in the brain which is derived from nucleobindin-2. Central and peripheral administration of nesfatin-1, inhibits food intake, dose-dependently. Hyperthyroid patients have increased appetite and food intake with a craving for carbohydrate-rich food, at the beginning of disease, but the physiological mechanisms underlying this behavior is not known exactly. In this study, we investigated whether nesfatin-1 is involved in the regulation of appetite and body weight in hyperthyroidism, or not.
  
  
  METHODS
  A total of 70 patients with subclinical (35) and overt hyperthyroidism (35) compared with 35 control patients. Serum nesfatin-1 level was measured from all samples by commercial ELISA kit.
  
  
  RESULTS
  Serum nesfatin-1 levels were similar between three groups (P=0.293). After adjusting for age and body mass index, nesfatin-1 levels in control group was not different from subclinical and overt hyperthyroid group, respectively (P=0.567 and P=0.519).
  
  
  CONCLUSIONS
  These data showed that serum nesfatin-1 levels do not significant change in overt and subclinical hyperthyroidism.
authors: Department of Endocrinology and Metabolic Diseases Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey - askn79@yahoo.com.
authors: A
authors: A
authors: Gungunes
authors: M
authors: M
authors: Ozbek
authors: Z
authors: Z
authors: Ginis
authors: M
authors: M
authors: Sahin
authors: T
authors: T
authors: Demirci
authors: E
authors: E
authors: Cakir Ozkaya
authors: B
authors: B
authors: Karbek
authors: M
authors: M
authors: Sayki Arslan
authors: I
authors: I
authors: Ozturk Unsal
authors: E
authors: E
authors: Tutal Akkaya
authors: B
authors: B
authors: Ucan
authors: S
authors: S
authors: Gultuna Ozguclu
authors: E
authors: E
authors: Cakal
authors: O
authors: O
authors: Topaloglu
authors: T
authors: T
authors: Delibasi
mesh_terms: D000328:Adult; D001066:Appetite / Q000502:physiology*; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology*; D002135:Calcium-Binding Proteins / Q000097:blood*; D003401:Creatine / Q000097:blood; D004268:DNA-Binding Proteins / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000097:blood*; D000080866:Nucleobindins; D013963:Thyroid Hormones / Q000097:blood; D013972:Thyrotropin / Q000097:blood; D015431:Weight Loss; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; C000630650:NUCB2 protein, human; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins; D013963:Thyroid Hormones; D013972:Thyrotropin; D003401:Creatine