title: Cytokinome profile evaluation in patients with hepatitis C virus infection.
abstract: The ''omics sciences'' (genomics, transcriptomics, proteomics) are often used to study living organisms as a whole system by evaluating the complex expression patterns of genes, miRNA, proteins, and metabolites. This study aimed, through bioinformatics and systems biology, to decipher the cytokinome profile in the evolution of inflammatory processes leading to cancer. The cytokinome was defined as the totality of cytokines and their interactions in and around biological cells. The system biology approach would provide a better understanding of the complex interaction network of cytokines, especially in cancer patients. Acquired knowledge would enable health providers with tools to evaluate disease onset through progression as well as identifying innovative therapeutic strategies. Understanding the role each cytokine plays in the metabolic network is of great importance. This paper reviews our group's ''omics'' work. In particular, it addresses the role cytokines play in liver disease in six different scenarios. The first is the role the cytokines play in chronic inflammatory diseases and cancers. The second is the significance of the cytokinome profile. The third is the role of liver cirrhosis as an inflammatory disease. The fourth is the comparison of cytokine levels evaluated in patients with chronic hepatitis C virus (HCV) or with HCV-related cirrhosis. The fifth is the comparison of cytokine levels evaluated in patients with HCV-related cirrhosis in the presence and absence of type 2 diabetes. And lastly, we present a comparison of cytokine levels evaluated in patients with HCV-related cirrhosis in the presence and absence of hepatocellular carcinoma.
authors: Francesca Capone, Eliana Guerriero, Giuseppe Castello, Susan Costantini, Centro Ricerche Oncologiche di Mercogliano, IstitutoNazionale per lo Studio e la CuradeiTumori "Fondazione Giovanni Pascale", IRCCS, 83013 Mecogliano, Italy.
authors: Francesca
authors: F
authors: Capone
authors: Francesca Capone, Eliana Guerriero, Giuseppe Castello, Susan Costantini, Centro Ricerche Oncologiche di Mercogliano, IstitutoNazionale per lo Studio e la CuradeiTumori "Fondazione Giovanni Pascale", IRCCS, 83013 Mecogliano, Italy.
authors: Eliana
authors: E
authors: Guerriero
authors: Francesca Capone, Eliana Guerriero, Giuseppe Castello, Susan Costantini, Centro Ricerche Oncologiche di Mercogliano, IstitutoNazionale per lo Studio e la CuradeiTumori "Fondazione Giovanni Pascale", IRCCS, 83013 Mecogliano, Italy.
authors: Giovanni
authors: G
authors: Colonna
authors: Francesca Capone, Eliana Guerriero, Giuseppe Castello, Susan Costantini, Centro Ricerche Oncologiche di Mercogliano, IstitutoNazionale per lo Studio e la CuradeiTumori "Fondazione Giovanni Pascale", IRCCS, 83013 Mecogliano, Italy.
authors: Patrizia
authors: P
authors: Maio
authors: Francesca Capone, Eliana Guerriero, Giuseppe Castello, Susan Costantini, Centro Ricerche Oncologiche di Mercogliano, IstitutoNazionale per lo Studio e la CuradeiTumori "Fondazione Giovanni Pascale", IRCCS, 83013 Mecogliano, Italy.
authors: Alessandra
authors: A
authors: Mangia
authors: Francesca Capone, Eliana Guerriero, Giuseppe Castello, Susan Costantini, Centro Ricerche Oncologiche di Mercogliano, IstitutoNazionale per lo Studio e la CuradeiTumori "Fondazione Giovanni Pascale", IRCCS, 83013 Mecogliano, Italy.
authors: Giuseppe
authors: G
authors: Castello
authors: Francesca Capone, Eliana Guerriero, Giuseppe Castello, Susan Costantini, Centro Ricerche Oncologiche di Mercogliano, IstitutoNazionale per lo Studio e la CuradeiTumori "Fondazione Giovanni Pascale", IRCCS, 83013 Mecogliano, Italy.
authors: Susan
authors: S
authors: Costantini
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000276:immunology / Q000821:virology; D016207:Cytokines / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000276:immunology; D019698:Hepatitis C, Chronic / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008103:Liver Cirrhosis / Q000097:blood / Q000276:immunology / Q000821:virology; D008113:Liver Neoplasms / Q000097:blood / Q000276:immunology / Q000821:virology; D011379:Prognosis; D040901:Proteomics / Q000379:methods; D049490:Systems Biology
chemical_list: D015415:Biomarkers; D016207:Cytokines; D018836:Inflammation Mediators
keywords: Cirrhosis; Cytokinome; Hepatitis C virus; Hepatocellular carcinoma; Interactome; Systems biology; Type 2 diabetes