title: Anemia of inflammation.
abstract: Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. It is diagnosed when serum iron concentrations are low despite adequate iron stores, as evidenced by serum ferritin that is not low. In the setting of inflammation, it may be difficult to differentiate AI from iron deficiency anemia, and the 2 conditions may coexist. Treatment should focus on the underlying disease. Recent advances in molecular understanding of AI are stimulating the development of new pathophysiologically targeted experimental therapies.
authors: Department of Medicine, David Geffen School of Medicine at UCLA, 37-055 CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA.
authors: Elizabeta
authors: E
authors: Nemeth
authors: Department of Medicine, David Geffen School of Medicine at UCLA, 37-055 CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA; Department of Pathology, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA. Electronic address: tganz@mednet.ucla.edu.
authors: Tomas
authors: T
authors: Ganz
mesh_terms: D000740:Anemia / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D006801:Humans; D007249:Inflammation / Q000150:complications*
keywords: Anemia of chronic disease; Cytokines; Erythropoiesis-stimulating agents; Ferroportin; Hepcidin