title: Liquid-phase enantioselective chromatographic resolution using interpenetrated, homochiral framework materials.
abstract: Effective separation of mixtures of enantiomers is of continuing interest in analytical and preparative chromatography, with new materials frequently designed and tested. We report two new enantiomerically pure 2D→3D interpenetrated materials used as stationary liquid chromatographic (LC) phases that are shown to resolve selected racemic mixtures with enantiomeric and chemical selectivity. Dicarboxylate ligands derived from amino acids on naphthalene and perylene cores form 2D frameworks that interpenetrate to give 3D structures. Selectivity is initially tested by uptake from solution; subsequent LC methods show that the materials exhibit resolution of racemic analytes in 'micro-columns' and that the two closely related materials show markedly different selectivity for different analytes with much greater activity than the ligands alone. Comparison with a close-packed analogue suggests that the separation activity is largely due to surface effects.
authors: School of Chemistry, Monash University, Clayton, VIC 3800 (Australia).
authors: Stephanie A
authors: SA
authors: Boer
authors: Yada
authors: Y
authors: Nolvachai
authors: Chadin
authors: C
authors: Kulsing
authors: Laura J
authors: LJ
authors: McCormick
authors: Chris S
authors: CS
authors: Hawes
authors: Philip J
authors: PJ
authors: Marriott
authors: David R
authors: DR
authors: Turner
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D002853:Chromatography, Liquid / Q000379:methods*; D018360:Crystallography, X-Ray; D003998:Dicarboxylic Acids / Q000737:chemistry*; D008024:Ligands; D008958:Models, Molecular; D009281:Naphthalenes / Q000737:chemistry; D010569:Perylene / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D003998:Dicarboxylic Acids; D008024:Ligands; D009281:Naphthalenes; C031721:naphthalene; D010569:Perylene
keywords: analytical chemistry; crystal engineering; gas chromatography; liquid chromatography; pi interactions