title: Microenvironmental factors and extracellular matrix degradation in pancreatic cancer.
abstract: Pancreatic cancer is a devastating malady with proclivity for early metastasis, accounting for its poor prognosis. Pancreatic ductal adenocarcinoma, the most common type of pancreatic malignancy, exhibits an over-expression of several growth factors such as epidermal growth factor and transforming growth factor beta, which correlate with a decrease in patient survival. These growth factors as well as hypoxia-reoxygenation conditions have been shown to increase pancreatic tumor cell invasiveness. This review will focus on the signaling pathways used by these distinct microenvironmental factors to promote extracellular matrix degradation and invasion by pancreatic tumor cells.
authors: Department of Molecular and Cell Biology, School of Dental Medicine, Boston University. Boston, MA, USA. licb@bu.edu.
authors: Marcelo G
authors: MG
authors: Binker
authors: Makena J
authors: MJ
authors: Binker-Cosen
authors: Andres A
authors: AA
authors: Binker-Cosen
authors: Laura I
authors: LI
authors: Cosen-Binker
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology*; D021441:Carcinoma, Pancreatic Ductal / Q000378:metabolism* / Q000473:pathology; D005109:Extracellular Matrix / Q000378:metabolism*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D008954:Models, Biological; D009361:Neoplasm Invasiveness; D010190:Pancreatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction; D059016:Tumor Microenvironment
chemical_list: D036341:Intercellular Signaling Peptides and Proteins