title: Role of cancer stem cell-associated inflammation in creating pro-inflammatory tumorigenic microenvironments.
abstract: We identify novel mechanisms whereby chemoresistance enables cancer stem cells to create pro-inflammatory tumor microenvironments. Chemoresistant cancer stem cells promote M2 macrophage differentiation through interferon-regulatory factor-5 (IRF5)- and macrophage-colony stimulating factor (M-CSF)-dependent mechanisms and produce various other cell-signaling factors that together fuel inflammation-driven carcinogenesis. These findings clarify a molecular pathway linking cancer "stemness" and pro-tumor inflammation in an immunosuppressive niche.
authors: Research Center for Infection-Associated Cancer; Institute for Genetic Medicine; Hokkaido University; Sapporo, Japan.
authors: Masahisa
authors: M
authors: Jinushi
keywords: IRF5; cancer stem cells; chemoresistance; inflammation-driven cancer; macrophage