title: Decreased levels of serum nesfatin-1 in patients with obstructive sleep apnea syndrome.
abstract: OBJECTIVE
  Recent evidences suggest that inflammation is involved in the mechanism of obstructive sleep apnea syndrome (OSAS). Nesfatin-1, recently identified as the satiety regulator, is implicated to possess an anti-inflammatory effect. The aim of our study is to investigate whether serum levels of nesfatin-1 are associated with the presence and severity of OSAS.
  
  
  METHODS
  A total of 196 patients with OSAS and 104 healthy subjects were enrolled in this study. Serum levels of nesfatin-1 were measured by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  OSAS patients showed significantly reduced levels of serum nesfatin-1 levels than healthy controls. Multivariable logistic regression analysis indicates that serum nesfatin-1 levels were inversely associated with the presence of OSAS (odds ration (OR) 0.003, 95% confidence interval (CI) 0.001 to 0.017; P < 0.001). Serum levels of nesfatin-1 were significantly decreased in severe OSAS patients compared with mild and moderate OSAS patients. Spearman correlation analysis showed that serum nesfatin-1 levels were inversely correlated with the severity of OSAS. In addition, Spearman correlation analysis showed that serum nesfatin-1 levels were negatively correlated with body mass index (BMI) (r = -0.299, P < 0.001), waist-hip ratio (WHR) (r = -0.277, P < 0.001), homeostasis model assessment of insulin resistance (HOMA-IR) (r = -0.338, P < 0.001), and apnea-hypopnea index (AHI) (r = -0.248, P < 0.001) in patients with OSAS.
  
  
  CONCLUSIONS
  Decreased serum nesfatin-1 levels are associated with the presence and severity of OSAS.
authors: Department of Emergency Medicine, Tianjin First Center Hospital, 24 Fukang Road, Nankai District, 300192, Tianjin, People's Republic of China.
authors: Peng
authors: P
authors: Shen
authors: Yingying
authors: Y
authors: Han
authors: Bo
authors: B
authors: Cai
authors: Yu
authors: Y
authors: Wang
mesh_terms: D015992:Body Mass Index; D002135:Calcium-Binding Proteins / Q000097:blood*; D016001:Confidence Intervals; D004268:DNA-Binding Proteins / Q000097:blood*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000097:blood*; D000080866:Nucleobindins; D016017:Odds Ratio; D017286:Polysomnography; D012016:Reference Values; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000145:classification / Q000175:diagnosis; D049629:Waist-Hip Ratio
chemical_list: D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; C000630650:NUCB2 protein, human; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins