title: Spindle-like polypyrrole hollow nanocapsules as multifunctional platforms for highly effective chemo-photothermal combination therapy of cancer cells in vivo.
abstract: The monodispersed spindle-like polypyrrole hollow nanocapsules (PPy HNCs) as the multifunctional platforms for combining chemotherapy with photothermal therapy for cancer cells are reported. Whereas the hollow cavity of nanocapsules can be used to load the anticancer drug (i.e., doxorubicin) for chemotherapy, the PPy shells can convert NIR light into heat for photothermal therapy. The release of the drug from the spindle-like PPy HNCs is pH-sensitive and near-infrared (NIR) light-enhanced. More importantly, the spindle-like PPy HNCs can penetrate cells more rapidly and efficiently in comparison with the spherical PPy HNCs. Both in vitro and in vivo experiments demonstrated that the combination of DOX-loaded spindle-like PPy HNCs and NIR light provide a highly effective and feasible chemo-photothermal therapy cancer method with a synergistic effect. Owing to their high photothermal conversion efficiency, large hollow cavity, and good biocompatibility, the spindle-like PPy HNCs could be used as a promising new cancer drug-nanocarrier and photothermal agent for localized tumorous chemo-photothermal therapy.
authors: Center for Biomaterials and Biopathways, Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027 (P.R. China), Fax: (+86) 571-87953736.
authors: Yang
authors: Y
authors: Wang
authors: Yun
authors: Y
authors: Xiao
authors: Ruikang
authors: R
authors: Tang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry; D005260:Female; D005290:Ferric Compounds / Q000008:administration & dosage / Q000737:chemistry; D056945:Hep G2 Cells; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008113:Liver Neoplasms / Q000188:drug therapy / Q000628:therapy*; D058185:Magnetite Nanoparticles / Q000008:administration & dosage / Q000737:chemistry; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D053769:Nanocapsules / Q000008:administration & dosage* / Q000737:chemistry; D010789:Phototherapy / Q000379:methods*; D011108:Polymers / Q000008:administration & dosage* / Q000737:chemistry; D011758:Pyrroles / Q000008:administration & dosage* / Q000737:chemistry; D014961:X-Ray Diffraction; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; D053769:Nanocapsules; D011108:Polymers; D011758:Pyrroles; C000499:ferric oxide; C067635:polypyrrole; D004317:Doxorubicin
keywords: UV/Vis spectroscopy; antitumor agents; cancer; drug delivery; nanoparticles