title: Rosacea and chronic rhinosinusitis: a case-controlled study.
abstract: OBJECTIVE
  To determine the relationship between rosacea, chronic rhinosinusitis (CRS), and the clinical presentation of rosacea.
  
  
  METHODS
  Twenty-eight female Saudi patients diagnosed with rosacea at the Dermatology Clinic, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia, between September 2011 and September 2012 and 20 age- and sex-matched control patients were included in the study. Paranasal sinus X-rays and assessments of the serum concentration of IgE (ImmunoCAP test; Phadia Laboratory Systems) were performed in both groups.
  
  
  RESULTS
  The rosacea patients had significantly more radiological evidence of CRS than the patients without rosacea [19 (67.9%) vs. 4 (20%), p = 0.003]. The median IgE concentration was similar in both groups (225.4 vs. 223.1 kU/l). Nine rosacea patients (32.1%) without radiological evidence of CRS did not have a significantly different median concentration of IgE compared with those who had radiological evidence of CRS (190.5 vs. 111.5 kU/l, p = 0.859). Erythematotelangiectatic severity was significantly associated with CRS (p = 0.038). Serum IgE did not correlate with the severity of the facial condition.
  
  
  CONCLUSIONS
  Patients with rosacea and CRS manifested severe erythematotelangiectatic rosacea. There was enough evidence to suggest an association between rosacea and CRS. Clinical and radiological assessments of the paranasal sinuses are recommended.
authors: Department of Dermatology (82), King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.
authors: Amal O
authors: AO
authors: Al-Balbeesi
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002908:Chronic Disease; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000150:complications; D007073:Immunoglobulin E; D008875:Middle Aged; D010256:Paranasal Sinuses / Q000000981:diagnostic imaging; D011859:Radiography; D012393:Rosacea / Q000150:complications*; D012529:Saudi Arabia; D012720:Severity of Illness Index; D012852:Sinusitis / Q000150:complications*
chemical_list: D007073:Immunoglobulin E