title: Mating competitiveness and life-table comparisons between transgenic and Indian wild-type Aedes aegypti L.
abstract: BACKGROUND
  OX513A is a genetically engineered strain of Aedes aegypti carrying a repressible, dominantly inherited transgene that confers lethality in immature heterozygous progeny. Released male OX513A adults have proven to be effective for the localised suppression of wild Ae. aegypti, highlighting its potential in vector control. Mating and life-table assessments were used to compare OX513A with reared Ae. aegypti strains collected from New Delhi and Aurangabad regions in India.
  
  
  RESULTS
  Mating proportions of New Delhi females versus males of OX513A or New Delhi strains were 0.52 and 0.48 respectively, indicating no discrimination by females against either strain, and males of both strains were equally competitive. Developmental time from first instar to adult emergence was significantly longer for OX513A (10.7 ± 0.04 days) than for New Delhi (9.4 ± 0.04 days) and Aurangabad strains (9.1 ± 0.04 days). Differences in mean longevities, female reproductive parameters and population growth parameters between the strains were non-significant.
  
  
  CONCLUSIONS
  The laboratory study demonstrates that only minor life-table variations of limited biological relevance exist between OX513A and Indian Ae. aegypti populations, and males had equal potential for mating competitiveness. Thus, results support the OX513A strain as a suitable candidate for continued evaluation towards sustainable management of Ae. aegypti populations in India.
authors: Gangabishan Bhikulal Investment and Trading Limited (GBIT), Jalna, Maharashtra State, India.
authors: Prabhakargouda B
authors: PB
authors: Patil
authors: Gangabishan Bhikulal Investment and Trading Limited (GBIT), Jalna, Maharashtra State, India.
authors: B P Niranjan
authors: BP
authors: Reddy
authors: Oxitec Limited, Abingdon, Oxfordshire, UK.
authors: Kevin
authors: K
authors: Gorman
authors: Gangabishan Bhikulal Investment and Trading Limited (GBIT), Jalna, Maharashtra State, India.
authors: K V Seshu
authors: KV
authors: Reddy
authors: Gangabishan Bhikulal Investment and Trading Limited (GBIT), Jalna, Maharashtra State, India.
authors: Shirish R
authors: SR
authors: Barwale
authors: Gangabishan Bhikulal Investment and Trading Limited (GBIT), Jalna, Maharashtra State, India.
authors: Usha B
authors: UB
authors: Zehr
authors: Oxitec Limited, Abingdon, Oxfordshire, UK.
authors: Derric
authors: D
authors: Nimmo
authors: Oxitec Limited, Abingdon, Oxfordshire, UK.
authors: Neil
authors: N
authors: Naish
authors: Oxitec Limited, Abingdon, Oxfordshire, UK.
authors: Luke
authors: L
authors: Alphey
mesh_terms: D000330:Aedes / Q000235:genetics* / Q000502:physiology*; D000818:Animals; D030801:Animals, Genetically Modified; D005260:Female; D056084:Genetic Fitness; D005838:Genotype; D007194:India; D008136:Longevity / Q000235:genetics; D008297:Male; D010572:Pest Control, Biological / Q000379:methods; D012098:Reproduction / Q000235:genetics; D012726:Sexual Behavior, Animal
keywords: Aedes aegypti; RIDL; dengue; mosquito; sterile insect technique; transgenic