title: Progressively increased M50 responses to repeated sounds in autism spectrum disorder with auditory hypersensitivity: a magnetoencephalographic study.
abstract: The aim of this study was to investigate the differential time-course responses of the auditory cortex to repeated auditory stimuli in children with autism spectrum disorder (ASD) showing auditory hypersensitivity. Auditory-evoked field values were obtained from 21 boys with ASD (12 with and 9 without auditory hypersensitivity) and 15 age-matched typically developing controls. M50 dipole moments were significantly increased during the time-course study only in the ASD with auditory hypersensitivity compared with those for the other two groups. The boys having ASD with auditory hypersensitivity also showed more prolonged response duration than those in the other two groups. The response duration was significantly related to the severity of auditory hypersensitivity. We propose that auditory hypersensitivity is associated with decreased inhibitory processing, possibly resulting from an abnormal sensory gating system or dysfunction of inhibitory interneurons.
authors: Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University Graduate School of Medicine, Osaka, Japan.
authors: Junko
authors: J
authors: Matsuzaki
authors: United Graduate School of Child Development, Osaka University Graduate School of Medicine, Osaka, Japan; Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka, Japan.
authors: Kuriko
authors: K
authors: Kagitani-Shimono
authors: Department of Neurosurgery, Osaka University Graduate School of Medicine, Osaka, Japan.
authors: Hisato
authors: H
authors: Sugata
authors: Department of Neurosurgery, Osaka University Graduate School of Medicine, Osaka, Japan.
authors: Masayuki
authors: M
authors: Hirata
authors: United Graduate School of Child Development, Osaka University Graduate School of Medicine, Osaka, Japan.
authors: Ryuzo
authors: R
authors: Hanaie
authors: Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University Graduate School of Medicine, Osaka, Japan.
authors: Fumiyo
authors: F
authors: Nagatani
authors: Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University Graduate School of Medicine, Osaka, Japan; United Graduate School of Child Development, Osaka University Graduate School of Medicine, Osaka, Japan; Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka, Japan.
authors: Masaya
authors: M
authors: Tachibana
authors: United Graduate School of Child Development, Osaka University Graduate School of Medicine, Osaka, Japan; Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka, Japan.
authors: Koji
authors: K
authors: Tominaga
authors: Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University Graduate School of Medicine, Osaka, Japan; United Graduate School of Child Development, Osaka University Graduate School of Medicine, Osaka, Japan; Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka, Japan.
authors: Ikuko
authors: I
authors: Mohri
authors: Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University Graduate School of Medicine, Osaka, Japan; United Graduate School of Child Development, Osaka University Graduate School of Medicine, Osaka, Japan; Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka, Japan.
authors: Masako
authors: M
authors: Taniike
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000704:Analysis of Variance; D001303:Auditory Cortex / Q000503:physiopathology*; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000150:complications / Q000503:physiopathology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D006801:Humans; D012001:Hyperacusis / Q000209:etiology / Q000503:physiopathology*; D015225:Magnetoencephalography / Q000379:methods; D008297:Male