title: Obstetric and perinatal outcome of babies born from vitrified oocytes.
abstract: OBJECTIVE
  To assess outcomes after oocyte vitrification on obstetric and perinatal outcomes compared with those achieved with fresh oocytes.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  Private university-affiliated IVF center.
  
  
  METHODS
  Children born after use of vitrified oocytes (1,027 from 804 pregnancies) and fresh oocytes (1,224 from 996 pregnancies). Singleton and multiples pregnancies from own and donated ova were included.
  
  
  METHODS
  Oocyte vitrification by the Cryotop method.
  
  
  METHODS
  Pregnancy, delivery, and neonatal outcomes.
  
  
  RESULTS
  Vitrification had no clinically relevant adverse effects on obstetric and perinatal outcomes after adjusting for potential confounders. No differences were found between the vitrified and fresh oocyte groups in the rate of obstetric problems (including diabetes, pregnancy-induced hypertension, preterm birth, anemia, and cholestasis), gestational age at delivery, birth weight, Apgar scores, birth defects, admission to neonatal intensive care unit (ICU), perinatal mortality, and puerperal problems. Only a greater number of invasive procedures (adjusted odds ratio 2.12; 95% confidence interval 1.41-3.20), and a reduced occurrence of urinary tract infection (adjusted odds ratio 0.51; 95% confidence interval 0.28-0.91), were observed in the vitrified oocytes group.
  
  
  CONCLUSIONS
  Although our data, the largest series to date, suggest that oocyte vitrification does not increase adverse obstetric and perinatal outcomes in children conceived with vitrified oocytes, further studies with larger samples are required to reinforce our conclusions.
authors: Instituto Valenciano de Infertilidad, Universidad de Valencia, Valencia, Spain. Electronic address: ana.cobo@ivi.es.
authors: Ana
authors: A
authors: Cobo
authors: Instituto Valenciano de Infertilidad, Universidad de Valencia, Valencia, Spain.
authors: Vicente
authors: V
authors: Serra
authors: Instituto Valenciano de Infertilidad, Universidad de Valencia, Valencia, Spain.
authors: Nicolás
authors: N
authors: Garrido
authors: Instituto Valenciano de Infertilidad, Universidad de Valencia, Valencia, Spain.
authors: Inés
authors: I
authors: Olmo
authors: Instituto Valenciano de Infertilidad, Universidad de Valencia, Valencia, Spain.
authors: Antonio
authors: A
authors: Pellicer
authors: Instituto Valenciano de Infertilidad, Universidad de Valencia, Valencia, Spain.
authors: José
authors: J
authors: Remohí
mesh_terms: D000328:Adult; D016009:Chi-Square Distribution; D015925:Cryopreservation; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects; D006801:Humans; D007246:Infertility / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D016015:Logistic Models; D015999:Multivariate Analysis; D016017:Odds Ratio; D054315:Oocyte Retrieval; D009865:Oocytes; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D016896:Treatment Outcome; D058989:Vitrification
keywords: Assisted reproduction; oocyte vitrification; perinatal outcome; pregnancy problems