title: Development and testing of a single frequency terahertz imaging system for breast cancer detection.
abstract: The ability to discern malignant from benign tissue in excised human breast specimens in Breast Conservation Surgery (BCS) was evaluated using single frequency terahertz radiation. Terahertz (THz) images of the specimens in reflection mode were obtained by employing a gas laser source and mechanical scanning. The images were correlated with optical histological micrographs of the same specimens, and a mean discrimination of 73% was found for five out of six samples using Receiver Operating Characteristic (ROC) analysis. The system design and characterization is discussed in detail. The initial results are encouraging but further development of the technology and clinical evaluation is needed to evaluate its feasibility in the clinical environment.
authors: Benjamin
authors: B
authors: St Peter
authors: Sigfrid
authors: S
authors: Yngvesson
authors: Paul
authors: P
authors: Siqueira
authors: Patrick
authors: P
authors: Kelly
authors: Ashraf
authors: A
authors: Khan
authors: Stephen
authors: S
authors: Glick
authors: Andrew
authors: A
authors: Karellas
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D004867:Equipment Design; D005260:Female; D006651:Histocytochemistry / Q000379:methods*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D012372:ROC Curve; D055069:Terahertz Imaging / Q000379:methods*