title: Trehalose accumulation enhances tolerance of Saccharomyces cerevisiae to acetic acid.
abstract: Trehalose confers protection against various environmental stresses on yeast cells. In this study, trehalase gene deletion mutants that accumulate trehalose at high levels showed significant stress tolerance to acetic acid. The enhancement of trehalose accumulation can thus be considered a target in the breeding of acetic acid-tolerant yeast strains.
authors: Research Division of Microbial Sciences, Kyoto University, Kitashirakawa Oiwake-Cho, Sakyo-ku, Kyoto 606-8502, Japan.
authors: Yoko
authors: Y
authors: Yoshiyama
authors: Research Division of Microbial Sciences, Kyoto University, Kitashirakawa Oiwake-Cho, Sakyo-ku, Kyoto 606-8502, Japan.
authors: Koichi
authors: K
authors: Tanaka
authors: River Basin Research Center, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
authors: Kohei
authors: K
authors: Yoshiyama
authors: Industrial Microbiology, Kyoto University, Kitashirakawa Oiwake-Cho, Sakyo-ku, Kyoto 606-8502, Japan.
authors: Makoto
authors: M
authors: Hibi
authors: Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwake-Cho, Sakyo-ku, Kyoto 606-8502, Japan.
authors: Jun
authors: J
authors: Ogawa
authors: Research Division of Microbial Sciences, Kyoto University, Kitashirakawa Oiwake-Cho, Sakyo-ku, Kyoto 606-8502, Japan. Electronic address: shima@agr.ryukoku.ac.jp.
authors: Jun
authors: J
authors: Shima
mesh_terms: D019342:Acetic Acid / Q000494:pharmacology*; D000431:Ethanol / Q000378:metabolism; D017353:Gene Deletion; D011422:Propionates / Q000494:pharmacology; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*; D013312:Stress, Physiological / Q000187:drug effects / Q000235:genetics; D014198:Trehalase / Q000172:deficiency / Q000235:genetics; D014199:Trehalose / Q000378:metabolism*
chemical_list: D011422:Propionates; D000431:Ethanol; D014199:Trehalose; D014198:Trehalase; C029658:propionic acid; D019342:Acetic Acid
keywords: Acetic acids; Bioethanol production; Propionic acid; Saccharomyces cerevisiae; Stress tolerance; Trehalose accumulation