title: Prehabilitation versus rehabilitation: a randomized control trial in patients undergoing colorectal resection for cancer.
abstract: BACKGROUND
  The preoperative period (prehabilitation) may represent a more appropriate time than the postoperative period to implement an intervention. The impact of prehabilitation on recovery of function al exercise capacity was thus studied in patients undergoing colorectal resection for cancer.
  
  
  METHODS
  A parallel-arm single-blind superiority randomized controlled trial was conducted. Seventy-seven patients were randomized to receive either prehabilitation (n = 38) or rehabilitation (n = 39). Both groups received a home-based intervention of moderate aerobic and resistance exercises, nutritional counseling with protein supplementation, and relaxation exercises initiated either 4 weeks before surgery (prehabilitation) or immediately after surgery (rehabilitation), and continued for 8 weeks after surgery. Patients were managed with an enhanced recovery pathway. Primary outcome was functional exercise capacity measured using the validated 6-min walk test.
  
  
  RESULTS
  Median duration of prehabilitation was 24.5 days. While awaiting surgery, functional walking capacity increased (≥ 20 m) in a higher proportion of the prehabilitation group compared with the rehabilitation group (53 vs. 15%, adjusted P = 0.006). Complication rates and duration of hospital stay were similar. The difference between baseline and 8-week 6-min walking test was significantly higher in the prehabilitation compared with the rehabilitation group (+23.7 m [SD, 54.8] vs. -21.8 m [SD, 80.7]; mean difference 45.4 m [95% CI, 13.9 to 77.0]). A higher proportion of the prehabilitation group were also recovered to or above baseline exercise capacity at 8 weeks compared with the rehabilitation group (84 vs. 62%, adjusted P = 0.049).
  
  
  CONCLUSIONS
  Meaningful changes in postoperative functional exercise capacity can be achieved with a prehabilitation program.
authors: From the Department of Anesthesia, McGill University Health Centre, Montreal, Quebec, Canada (C.G., R.A., B.A.); and Department of Surgery (C.L., L.L., A.S.L., B.S., P.C., L.S.F.) and Department of Anesthesia (A.G., F.C.), McGill University, Montreal, Quebec, Canada.
authors: Chelsia
authors: C
authors: Gillis
authors: Chao
authors: C
authors: Li
authors: Lawrence
authors: L
authors: Lee
authors: Rashami
authors: R
authors: Awasthi
authors: Berson
authors: B
authors: Augustin
authors: Ann
authors: A
authors: Gamsa
authors: A Sender
authors: AS
authors: Liberman
authors: Barry
authors: B
authors: Stein
authors: Patrick
authors: P
authors: Charlebois
authors: Liane S
authors: LS
authors: Feldman
authors: Francesco
authors: F
authors: Carli
mesh_terms: D000368:Aged; D015179:Colorectal Neoplasms / Q000601:surgery*; D015444:Exercise; D005081:Exercise Therapy; D017079:Exercise Tolerance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D044623:Nutrition Therapy; D011182:Postoperative Care / Q000379:methods*; D011300:Preoperative Care / Q000379:methods*; D055070:Resistance Training; D016037:Single-Blind Method; D016896:Treatment Outcome; D016138:Walking / Q000502:physiology