title: [Activity of the inositol-containing phospholipid dimer analogues against human immunodeficiency virus].
abstract: For the purpose of finding effective inhibitors of virus adsorption the series of inositol-containing phospholipid dimer analogues were previously synthesized. In the present work, the antiretroviral activity of these compounds against HIV-1 was demonstrated on the model of cells infected with the virus. The highest effect was found in the case of dimer poliol 5, EC50 (50%-effective concentration) was 3.9 microg/ml. The development of new polyanionic compounds, which can interfere with early steps of the virus life cycle, is a promising addition to the antiretroviral therapy based on the virus enzyme inhibitors.
authors: E O
authors: EO
authors: Baranova
authors: N S
authors: NS
authors: Shastina
authors: O A
authors: OA
authors: Lobach
authors: M S
authors: MS
authors: Chataeva
authors: D N
authors: DN
authors: Nosik
authors: V I
authors: VI
authors: Shvets
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D015658:HIV Infections / Q000188:drug therapy*; D015497:HIV-1 / Q000378:metabolism*; D006801:Humans; D007294:Inositol / Q000737:chemistry / Q000494:pharmacology*; D010743:Phospholipids / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D019380:Anti-HIV Agents; D010743:Phospholipids; D007294:Inositol