title: Effect of pharmacological intervention on MIP-1α, MIP-1β and MCP-1 expression in patients with psoriasis vulgaris.
abstract: OBJECTIVE
  To detect the expression level of macrophage inflammatory protein-1 (MIP-1)α, MIP-1β and monocyte chemoattractant protein-1 (MCP-1) in with psoriasis vulgaris and explore the role in the pathogenesis of psoriasis vulgaris.
  
  
  METHODS
  The level of MIP-1α, MIP-1β and MCP-1 in peripheral blood from 50 patients with psoriasis vulgaris and 50 normal controls were measured by enzyme linked immunosorbent assay. The correlation with psoriasis area and severity index (PASI) was analyzed. The level of MIP-1α, MIP-1β and MCP-1 was compared between psoriasis vulgaris patients at active stage and resting stage. And the change in MIP-1α, MIP-1β and MCP-1 before and after therapy was also observed.
  
  
  RESULTS
  The content of MIP-1α, MIP-1β and MCP-1 in patients with psoriasis vulgaris was (1342.78 ± 210.30), (175.28 ± 28.18) and (266.86 ± 32.75) ng/L, respectively, significantly higher than those in control group (P<0.05). The expression level of MIP-1α, MIP-1β and MCP-1 in peripheral blood of patients with psoriasis vulgaris was positively correlated with PASI (P<0.01). After acitretin therapy, expression level of MIP-1α, MIP-1β and MCP-1 in peripheral blood of patients with psoriasis vulgaris was significantly decreased.
  
  
  CONCLUSIONS
  Chemokine factor MIP-1α, MIP-1β and MCP-1 may be involved in the pathogenesis of psoriasis vulgaris.
authors: Department of Dermatology, Affiliated Hospital of Hainan Medical College, Haikou 570102, China.
authors: Yong-Jiang
authors: YJ
authors: Dai
authors: Department of Dermatology, Sanya Agricultural Reclamation Hospital, SanYa 57200, China.
authors: Yu-Yang
authors: YY
authors: Li
authors: Department of Dermatology, Affiliated Hospital of Hainan Medical College, Haikou 570102, China.
authors: Hui-Ming
authors: HM
authors: Zeng
authors: Department of Dermatology, Affiliated Hospital of Hainan Medical College, Haikou 570102, China.
authors: Xiong-An
authors: XA
authors: Liang
authors: Department of Dermatology, Sanya Agricultural Reclamation Hospital, SanYa 57200, China.
authors: Zhi-Jie
authors: ZJ
authors: Xie
authors: Department of Dermatology, Sanya Agricultural Reclamation Hospital, SanYa 57200, China.
authors: Zhi-Ang
authors: ZA
authors: Zheng
authors: Department of Dermatology, Sanya Agricultural Reclamation Hospital, SanYa 57200, China.
authors: Qin-Hui
authors: QH
authors: Pan
authors: Department of Dermatology, Sanya Agricultural Reclamation Hospital, SanYa 57200, China.
authors: Yi-Xiong
authors: YX
authors: Xing
mesh_terms: D017255:Acitretin / Q000627:therapeutic use; D000328:Adult; D016022:Case-Control Studies; D018932:Chemokine CCL2 / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007641:Keratolytic Agents / Q000627:therapeutic use; D019402:Macrophage Inflammatory Proteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood* / Q000188:drug therapy* / Q000453:epidemiology; D016559:Tacrolimus / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D018932:Chemokine CCL2; D007166:Immunosuppressive Agents; D007641:Keratolytic Agents; D019402:Macrophage Inflammatory Proteins; D017255:Acitretin; D016559:Tacrolimus
keywords: Macrophage inflammatory protein-1; Monocyte chemoattractant protein-1; Psoriasis vulgaris