title: Affinity chemiresistor sensor for sugars.
abstract: In this work, a non-enzymatic chemiresistive sugar sensor has been developed by combining a synthetic receptor with aligned single-walled carbon nanotubes (SWNTs) device. Briefly, boronic acid as a multivalent sugar receptor was immobilized on carbon nanotubes through amide bond formation. The interaction between three common sugars (d-glucose, d-fructose and sucrose) and boronic acid modified SWNTs device was studied. The effect of pH on the receptor-ligand binding was examined and highest response was observed at pH 9. The chemiresistive sensor exhibited specific and reproducible detection with sensitivity over the concentration range of 1-20mM, 1-25 mM, and 1-30 mM for fructose, glucose, and sucrose, respectively. The sensor showed no interference from common electroactive compounds such as citric acid, uric acid, and ascorbic acid. Furthermore, the sensor retained 97.4% of the initial value after five regeneration cycles with an acidic buffer at pH 5, thus ensuring good reusability.
authors: Department of Chemical and Environmental Engineering, University of California, Riverside, CA 92521, USA. Electronic address: chaker_tlili@yahoo.fr.
authors: Chaker
authors: C
authors: Tlili
authors: Department of Electrical Engineering, University of California, Riverside, CA 92521, USA. Electronic address: sbadh001@ucr.edu.
authors: Sushmee
authors: S
authors: Badhulika
authors: Department of Bioengineering, University of California, Riverside, CA 92521, USA. Electronic address: ttran0096@ucr.edu.
authors: Thien-Toan
authors: TT
authors: Tran
authors: Department of Chemistry, University of California, Riverside, CA 92521, USA. Electronic address: ilkeun.lee@ucr.edu.
authors: Ilkeun
authors: I
authors: Lee
authors: Department of Chemical and Environmental Engineering, University of California, Riverside, CA 92521, USA. Electronic address: adani@engr.ucr.edu.
authors: Ashok
authors: A
authors: Mulchandani
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D001897:Boronic Acids / Q000737:chemistry*; D002241:Carbohydrates / Q000032:analysis* / Q000737:chemistry; D005632:Fructose / Q000032:analysis / Q000737:chemistry; D005947:Glucose / Q000032:analysis / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D037742:Nanotubes, Carbon / Q000737:chemistry*; D015203:Reproducibility of Results; D013395:Sucrose / Q000032:analysis / Q000737:chemistry
chemical_list: D001897:Boronic Acids; D002241:Carbohydrates; D037742:Nanotubes, Carbon; D005632:Fructose; D013395:Sucrose; D005947:Glucose
keywords: Boronic acid; Non-enzymatic sensor; Single-walled carbon nanotubes; Sugar