title: Sedentary behavior is associated with colorectal adenoma recurrence in men.
abstract: OBJECTIVE
  The association between physical activity and colorectal adenoma is equivocal. This study was designed to assess the relationship between physical activity and colorectal adenoma recurrence.
  
  
  METHODS
  Pooled analyses from two randomized, controlled trials included 1,730 participants who completed the Arizona Activity Frequency Questionnaire at baseline, had a colorectal adenoma removed within 6 months of study registration, and had a follow-up colonoscopy during the trial. Logistic regression modeling was employed to estimate the effect of sedentary behavior, light-intensity physical activity, and moderate-vigorous physical activity on colorectal adenoma recurrence.
  
  
  RESULTS
  No statistically significant trends were found for any activity type and odds of colorectal adenoma recurrence in the pooled population. However, males with the highest levels of sedentary time experienced 47% higher odds of adenoma recurrence. Compared to the lowest quartile of sedentary time, the ORs (95% CIs) for the second, third, and fourth quartiles among men were 1.23 (0.88, 1.74), 1.41 (0.99, 2.01), and 1.47 (1.03, 2.11), respectively (p(trend) = 0.03). No similar association was observed for women.
  
  
  CONCLUSIONS
  This study suggests that sedentary behavior is associated with a higher risk of colorectal adenoma recurrence among men, providing evidence of detrimental effects of a sedentary lifestyle early in the carcinogenesis pathway.
authors: Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 W. 168th St., Room 729, New York, NY, 10032, USA, cs3235@columbia.edu.
authors: Christine L Sardo
authors: CL
authors: Molmenti
authors: Elizabeth A
authors: EA
authors: Hibler
authors: Erin L
authors: EL
authors: Ashbeck
authors: Cynthia A
authors: CA
authors: Thomson
authors: David O
authors: DO
authors: Garcia
authors: Denise
authors: D
authors: Roe
authors: Robin B
authors: RB
authors: Harris
authors: Peter
authors: P
authors: Lance
authors: Martin
authors: M
authors: Cisneroz
authors: Maria Elena
authors: ME
authors: Martinez
authors: Patricia A
authors: PA
authors: Thompson
authors: Elizabeth T
authors: ET
authors: Jacobs
mesh_terms: D000236:Adenoma / Q000453:epidemiology*; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D001130:Arizona; D017326:Clinical Trials, Phase III as Topic; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000453:epidemiology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D057185:Sedentary Behavior; D017678:Sex Distribution; D012737:Sex Factors; D011795:Surveys and Questionnaires