title: Synthesis and immunological evaluation of self-adjuvanting MUC1-macrophage activating lipopeptide 2 conjugate vaccine candidates.
abstract: We describe herein the synthesis and immunological evaluation of self-adjuvanting mucin 1 (MUC1)-macrophage activating lipopeptide 2 (MALP2) (glyco)peptide vaccine candidates. Vaccine constructs were shown to induce high titres of class-switched IgG antibodies in C57BL/6 mice after four immunisations despite the lack of a helper T cell epitope.
authors: School of Chemistry, The University of Sydney, NSW 2006, Australia. richard.payne@sydney.edu.au.
authors: David M
authors: DM
authors: McDonald
authors: Brendan L
authors: BL
authors: Wilkinson
authors: Leo
authors: L
authors: Corcilius
authors: Morten
authors: M
authors: Thaysen-Andersen
authors: Scott N
authors: SN
authors: Byrne
authors: Richard J
authors: RJ
authors: Payne
mesh_terms: D000276:Adjuvants, Immunologic / Q000138:chemical synthesis*; D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D019496:Cancer Vaccines / Q000138:chemical synthesis* / Q000276:immunology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D055666:Lipopeptides / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D018396:Mucin-1 / Q000008:administration & dosage / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D001323:Autoantibodies; D019496:Cancer Vaccines; D055666:Lipopeptides; D018396:Mucin-1; C577056:muc1 protein, mouse; C106335:macrophage stimulatory lipopeptide 2