title: Evaluation of the effects of hydroalcoholic extract of Berberis vulgaris root on the activity of liver enzymes in male hypercholesterolemic rats.
abstract: OBJECTIVE
  Hyperlipidemia can cause a variety of diseases such as atherosclerosis, diabetes, and fatty liver which is followed by increased liver enzymes. Since Berberis vulgaris (B. vulgaris) root possesses antioxidant properties, the present study was conducted to investigate the effect of its extract on the activity of liver enzymes in rats.
  
  
  METHODS
  In this experimental study, sixty Wistar rats were selected and allocated to six groups of ten each. The control group received a normal diet and the sham group received a fatty diet while the other groups including experimental groups received a fatty diet and the alcoholic extract of B. vulgaris at minimum (75 mg/kg), moderate (150 mg/kg), and maximum (300 mg/kg) doses by intraperitoneal injection (i.p.) or oral atorvastatin (10 mg /kg) with a fatty diet. At the end of this 21-day period, blood samples were drawn and the levels of the intended factors were measured. Data were analyzed using SPSS software version 11.5.
  
  
  RESULTS
  The comparison of the obtained results showed that the levels of alanine transaminase (ALT) and alkaline phosphatase (ALP) enzymes in the sham group that only received fatty food increased (p≤0.05), whereas in the treatment groups receiving B. vulgaris extract as well as in the group receiving Atorvastatin, these enzymes significantly decreased; however, no significant changes were observed in aspartate transaminase (AST) levels.
  
  
  CONCLUSIONS
  Noticing the antioxidant properties of B. vulgaris root extract and its effects on reducing the activity of liver enzymes, the extract of this plant can be a good choice for improving the function of liver.
authors: Department of Physiology, Arak University of Medical Sciences, Arak, I. R. Iran.
authors: Soheila
authors: S
authors: Taheri
authors: Islamic Azad University of Damghan, Damghan, I. R. Iran.
authors: Ali
authors: A
authors: Zarei
authors: Department of Physiology, Arak University of Medical Sciences, Arak, I. R. Iran.
authors: Saeed
authors: S
authors: Changizi Ashtiyani
authors: Islamic Azad University of Arsanjan, Arsanjan , I. R. Iran.
authors: Azam
authors: A
authors: Rezaei
authors: Department of Biology, Payame Noor University of Abadeh, Abadeh , I. R. Iran.
authors: Saeed
authors: S
authors: Zaheiri