title: Influenza and coronary artery disease: exploring a clinical association with myocardial infarction and analyzing the utility of vaccination in prevention of myocardial infarction.
abstract: Both coronary artery disease and influenza outbreaks contribute significantly to worldwide morbidity and mortality. An increasing number of epidemiologic studies have concluded that a temporal association exists between acute viral illnesses and myocardial infarction. Viral illnesses such as influenza can cause or exacerbate coronary atherosclerosis by activating inflammatory pathways. Data from a large case-controlled trial and two randomized controlled trials suggest that influenza vaccination in patients with coronary artery disease may lead to a decrease in incidence, morbidity, and mortality from acute myocardial infarction. A meta-analysis of the two randomized controlled trials for cardiovascular death demonstrated a pooled relative risk of 0.39 (95% confidence interval, 0.20-0.77) for patients who received the influenza vaccine compared with placebo.
authors: Shrinivas
authors: S
authors: Hebsur
authors: Erik
authors: E
authors: Vakil
authors: William J
authors: WJ
authors: Oetgen
authors: Princy N
authors: PN
authors: Kumar
authors: MedStar Washington Hospital Center, Washington, DC; MedStar Georgetown University Hospital, Washington, DC.
authors: Daisy F
authors: DF
authors: Lazarous
mesh_terms: D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000517:prevention & control / Q000821:virology; D007252:Influenza Vaccines / Q000008:administration & dosage*; D007251:Influenza, Human / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D009203:Myocardial Infarction / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D011379:Prognosis; D012307:Risk Factors; D014611:Vaccination
chemical_list: D007252:Influenza Vaccines