title: A Whole Genome Association Study on Meat Quality Traits Using High Density SNP Chips in a Cross between Korean Native Pig and Landrace.
abstract: A whole genome association (WGA) study was performed to detect significant polymorphisms for meat quality traits in an F2 cross population (N = 478) that were generated with Korean native pig sires and Landrace dams in National Livestock Research Institute, Songwhan, Korea. The animals were genotyped using Illumina porcine 60k SNP beadchips, in which a set of 46,865 SNPs were available for the WGA analyses on ten carcass quality traits; live weight, crude protein, crude lipids, crude ash, water holding capacity, drip loss, shear force, CIE L, CIE a and CIE b. Phenotypes were regressed on additive and dominance effects for each SNP using a simple linear regression model, after adjusting for sex, sire and slaughter stage as fixed effects. With the significant SNPs for each trait (p<0.001), a stepwise regression procedure was applied to determine the best set of SNPs with the additive and/or dominance effects. A total of 106 SNPs, or quantitative trait loci (QTL) were detected, and about 32 to 66% of the total phenotypic variation was explained by the significant SNPs for each trait. The QTL were identified in most porcine chromosomes (SSCs), in which majority of the QTL were detected in SSCs 1, 2, 12, 13, 14 and 16. Several QTL clusters were identified on SSCs 12, 16 and 17, and a cluster of QTL influencing crude protein, crude lipid, drip loss, shear force, CIE a and CIE b were located between 20 and 29 Mb of SSC12. A pleiotropic QTL for drip loss, CIE L and CIE b was also detected on SSC16. These QTL need to be validated in commercial pig populations for genetic improvement in meat quality via marker-assisted selection.
authors: Animal Genomics and Bioinformatics Division, National Institute of Animal Science, Suwon, Korea .
authors: K-T
authors: KT
authors: Lee
authors: Animal Genomics and Bioinformatics Division, National Institute of Animal Science, Suwon, Korea .
authors: Y-M
authors: YM
authors: Lee
authors: Animal Genomics and Bioinformatics Division, National Institute of Animal Science, Suwon, Korea .
authors: M
authors: M
authors: Alam
authors: Animal Genomics and Bioinformatics Division, National Institute of Animal Science, Suwon, Korea .
authors: B H
authors: BH
authors: Choi
authors: Animal Genomics and Bioinformatics Division, National Institute of Animal Science, Suwon, Korea .
authors: M R
authors: MR
authors: Park
authors: Department of Animal Science, Chungbuk National University, Cheongju, Korea .
authors: K-S
authors: KS
authors: Kim
authors: Animal Genomics and Bioinformatics Division, National Institute of Animal Science, Suwon, Korea .
authors: T-H
authors: TH
authors: Kim
authors: Animal Genomics and Bioinformatics Division, National Institute of Animal Science, Suwon, Korea .
authors: J-J
authors: JJ
authors: Kim
keywords: Korean Native Pig; Landrace; Meat Quality; SNP; Whole Genome Association