title: Preparation of ibuprofen-loaded chitosan films for oral mucosal drug delivery using supercritical solution impregnation.
abstract: Drug-loaded chitosan films suitable for oral mucosal drug delivery were prepared using supercritical solution impregnation (SSI) technology. Firstly, chitosan films were obtained via casting method, and the film properties including water-uptake, erosion and mucoadhesive were characterized. SSI process was then employed to load the drug of ibuprofen onto the prepared chitosan films, and the effects of impregnation pressure and temperature on morphologies of the ibuprofen-loaded chitosan films and drug loading capacity (DLC) were studied. The SEM and X-ray diffraction patterns suggested that distinct ibuprofen shapes such as microparticles, flake, rod-like and needle-like occurred after impregnation at different pressures, and DLC varied from 7.9% to 130.4% during the SSI process. The ex vivo release profiles showed that ibuprofen-loaded chitosan films could deliver the drug across the rabbit buccal mucosa, and up to 70% of the ibuprofen was released from the matrix in 460 min. SSI process is a promising method to prepare drug-loaded film formulations for oral mucosal drug delivery, which provides the advantages of low solvent residual and sustained- and controlled- release behavior.
authors: Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.
authors: Chuan
authors: C
authors: Tang
authors: Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China. Electronic address: guanyx@zju.edu.cn.
authors: Yi-Xin
authors: YX
authors: Guan
authors: Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.
authors: Shan-Jing
authors: SJ
authors: Yao
authors: Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.
authors: Zi-Qiang
authors: ZQ
authors: Zhu
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry*; D058491:Bacterial Load; D048271:Chitosan / Q000008:administration & dosage / Q000737:chemistry*; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods; D005260:Female; D007052:Ibuprofen / Q000008:administration & dosage / Q000737:chemistry*; D009061:Mouth Mucosa / Q000378:metabolism; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000254:growth & development; D011817:Rabbits; D012996:Solutions; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D012996:Solutions; D048271:Chitosan; D007052:Ibuprofen
keywords: Ibuprofen; In vitro and ex vivo release; Mucoadhesive chitosan film; Oral mucosal drug delivery system; Supercritical solution impregnation