title: Brachial pulse pressure and cardiovascular or all-cause mortality in the general population: a meta-analysis of prospective observational studies.
abstract: This study aimed to quantitatively evaluate the predictive value of brachial pulse pressure and cardiovascular or all-cause mortality in the general population based on prospective observational studies by conducting a meta-analysis. Only prospective observational studies investigating baseline brachial pulse pressure and cardiovascular or all-cause mortality risk were selected from PubMed and Embase databases until July 2013. Fourteen studies involving 510,456 participants were analyzed. Pooled risk ratio (RR) of cardiovascular and all-cause mortality for the highest vs lowest brachial pulse pressure category was 1.80 (95% confidence interval [CI], 1.49-2.17) and 1.32 (95% CI, 1.23-1.41), respectively. Pooled RR of cardiovascular and all-cause mortality per 10 mm Hg pulse pressure increment was 1.13 (95% CI, 1.10-1.17) and 1.09 (95% CI, 1.07-1.11), respectively. Wide brachial pulse pressure is associated with greater risk of cardiovascular and all-cause mortality. However, more well-designed studies specifically on age and sex are needed to further confirm these findings.
authors: Department of Cardiovascular-Internal Medicine, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China.
authors: Leilei
authors: L
authors: Zhao
authors: Yijuan
authors: Y
authors: Song
authors: Pingshuan
authors: P
authors: Dong
authors: Zhijuan
authors: Z
authors: Li
authors: Xuming
authors: X
authors: Yang
authors: Shaoxin
authors: S
authors: Wang
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000502:physiology*; D001916:Brachial Artery / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000401:mortality*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D064887:Observational Studies as Topic; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012307:Risk Factors; D012737:Sex Factors