title: Association of miR-149C>T and miR-499A>G polymorphisms with the risk of hepatocellular carcinoma in the Chinese population.
abstract: We investigate the potential association of miR-149C>T and miR-499A>G polymorphisms and the risk of hepatocellular carcinoma (HCC). A matched case-control study of 152 cases and 304 controls were conducted. The miR-149C>T and miR-499A>G genotypes were analyzed using duplex polymerase chain reaction with restricted fragment length polymorphism. HCC patients were more likely to be smokers and drinkers, have hepatitis B and C virus infections, and a family history of cancer. The miR-149 CC genotype was associated with a reduced risk of HCC, while the miR-499 GG genotype was associated with an increased risk of HCC. However, we did not find that the miR-149 CC and miR-499 GG genotypes were associated with risk of HCC, and no interaction was found between miR-149C>T and miR-499A>G polymorphisms and hepatitis B virus infection. In conclusion, the miRNA-149C>T and miR-499A>G polymorphisms were found to play an important role for HCC risk in China. This finding could be useful in identifying people at high risk for the disease for early intervention.
authors: General Surgery Department, Huashan Hospital of Fudan University, Shanghai, China.
authors: X H
authors: XH
authors: Wang
authors: General Surgery Department, Huashan Hospital of Fudan University, Shanghai, China.
authors: F R
authors: FR
authors: Wang
authors: General Surgery Department, Huashan Hospital of Fudan University, Shanghai, China yanqizhao699@163.com.
authors: Y F
authors: YF
authors: Tang
authors: Tumor Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
authors: H Z
authors: HZ
authors: Zou
authors: Tumor Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
authors: Y Q
authors: YQ
authors: Zhao
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006509:Hepatitis B / Q000150:complications / Q000235:genetics / Q000473:pathology; D006526:Hepatitis C / Q000150:complications / Q000235:genetics / Q000473:pathology; D006801:Humans; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008113:Liver Neoplasms / Q000150:complications / Q000235:genetics* / Q000473:pathology; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D012307:Risk Factors; D012907:Smoking
chemical_list: C551557:MIRN149 microRNA, human; C548683:MIRN499 microRNA, human; D035683:MicroRNAs