title: MicroRNA-370 suppresses proliferation and promotes endometrioid ovarian cancer chemosensitivity to cDDP by negatively regulating ENG.
abstract: MicroRNAs (miRNAs) are a class of non-coding RNAs that post-transcriptionally inhibit gene expression. In this study, we discovered that microRNA-370 (miR-370) was down-regulated in endometrioid ovarian cancer cells. In IGROV1 and TOV112D endometrioid ovarian cancer cells, miR-370 suppressed cellular viability and colony formation. miR-370 also enhanced endometrioid ovarian cancer cell chemosensitivity to cDDP. Endoglin (ENG) was directly and negatively regulated by miR-370. In addition, hypermethylation was a potential mechanism of miR-370 epigenetic silencing. We conclude that miR-370 acts as a tumor suppressor in endometrioid ovarian cancer via ENG regulation.
authors: Department of Obstetrics and Gynaecology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China; Department of Obstetrics and Gynaecology, Yancheng 1th People Hospital, Yancheng, Jiangsu Province, China.
authors: Xiao-Ping
authors: XP
authors: Chen
authors: Department of Obstetrics and Gynaecology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.
authors: You-Guo
authors: YG
authors: Chen
authors: Department of Obstetrics and Gynaecology, Yancheng 1th People Hospital, Yancheng, Jiangsu Province, China.
authors: Jian-Yun
authors: JY
authors: Lan
authors: Department of Obstetrics and Gynaecology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China. Electronic address: zongjishen2013@163.com.
authors: Zong-Ji
authors: ZJ
authors: Shen
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000235:genetics* / Q000378:metabolism; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001483:Base Sequence; D018269:Carcinoma, Endometrioid / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002945:Cisplatin / Q000494:pharmacology*; D015536:Down-Regulation; D019008:Drug Resistance, Neoplasm; D000071063:Endoglin; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D035683:MicroRNAs / Q000502:physiology*; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D034622:RNA Interference; D011956:Receptors, Cell Surface / Q000235:genetics* / Q000378:metabolism; D047368:Tumor Burden; D023041:Xenograft Model Antitumor Assays
chemical_list: D015703:Antigens, CD; D000970:Antineoplastic Agents; C064206:ENG protein, human; D000071063:Endoglin; C526503:MIRN370 microRNA, human; D035683:MicroRNAs; D011956:Receptors, Cell Surface; D002945:Cisplatin
keywords: Endoglin; Endometrioid ovarian cancer; MicroRNA; Target gene; miR-370