title: The physiological mechanism for sensing nasal airflow: a literature review.
abstract: BACKGROUND
  Nasal obstruction is a common otolaryngologic complaint, yet the mechanism of sensing airflow is not commonly understood. The objective of this work was to review current knowledge on the physiological mechanism for sensing nasal airflow.
  
  
  METHODS
  Current literature pertaining to nasal sensation to airflow was retrieved using PubMed and Google Scholar searches.
  
  
  RESULTS
  The primary physiological mechanism that produces the sensation of ample nasal airflow is activation of trigeminal cool thermoreceptors, specifically transient receptor potential melastatin family member 8 (TRPM8), by nasal mucosal cooling. The dynamic change in temperature is ultimately sensed. Nasal mucosal cooling is a result of conductive heat loss, driven by temperature gradient, and evaporative heat loss, driven by humidity gradient. The perception of ample nasal airflow is dependent on the overall nasal surface area stimulated by mucosal cooling, which is mainly governed by air flow patterns. Cool thermoreceptors in the nasal mucosa are connected to the respiratory centers and consequently can alter respiration patterns. Mechanoreceptors do not seem to play a role in sensing nasal airflow. Computational fluid dynamics (CFD) modeling could be a valuable objective tool in evaluating patients with nasal congestion.
  
  
  CONCLUSIONS
  Understanding the physiological mechanism of how the nose senses airflow can aid in diagnosing the cause behind patient symptoms, which allows physicians to provide better treatment options for patients.
authors: Northeast Ohio Medical University, Rootstown, OH.
authors: Jeanie
authors: J
authors: Sozansky
authors: Steven M
authors: SM
authors: Houser
mesh_terms: D001833:Body Temperature Regulation / Q000502:physiology; D003198:Computer Simulation; D006801:Humans; D009296:Nasal Cavity / Q000502:physiology*; D009297:Nasal Mucosa / Q000502:physiology*; D015508:Nasal Obstruction / Q000503:physiopathology*; D012123:Pulmonary Ventilation / Q000502:physiology
keywords: TRPM8; computational fluid dynamics modeling; mucosal cooling; nasal airflow sensation; nasal congestion