title: Noninvasive in vivo glucose sensing on human subjects using mid-infrared light.
abstract: Mid-infrared quantum cascade laser spectroscopy is used to noninvasively predict blood glucose concentrations of three healthy human subjects in vivo. We utilize a hollow-core fiber based optical setup for light delivery and collection along with a broadly tunable quantum cascade laser to obtain spectra from human subjects and use standard chemo-metric techniques (namely partial least squares regression) for prediction analysis. Throughout a glucose concentration range of 80-160 mg/dL, we achieve clinically accurate predictions 84% of the time, on average. This work opens a new path to a noninvasive in vivo glucose sensor that would benefit the lives of hundreds of millions of diabetics worldwide.
authors: Department of Electrical Engineering, Princeton University, Princeton, NJ 08544, USA.
authors: Sabbir
authors: S
authors: Liakat
authors: Department of Electrical Engineering, Princeton University, Princeton, NJ 08544, USA.
authors: Kevin A
authors: KA
authors: Bors
authors: Department of Electrical Engineering, Princeton University, Princeton, NJ 08544, USA.
authors: Laura
authors: L
authors: Xu
authors: Department of Electrical Engineering, Princeton University, Princeton, NJ 08544, USA.
authors: Callie M
authors: CM
authors: Woods
authors: Department of Electrical Engineering, Princeton University, Princeton, NJ 08544, USA ; Permanent Address: Hunterdon Regional Central High School, Flemington, NJ 08822, USA.
authors: Jessica
authors: J
authors: Doyle
authors: Department of Electrical Engineering, Princeton University, Princeton, NJ 08544, USA.
authors: Claire F
authors: CF
authors: Gmachl
keywords: (140.5965) Semiconductor lasers, quantum cascade; (170.1470) Blood or tissue constituent monitoring; (300.6340) Spectroscopy, infrared