title: Multicenter study on acute and long-term safety and efficacy of percutaneous left atrial appendage closure using an epicardial suture snaring device.
abstract: BACKGROUND
  Pericardial suture ligation of the left atrial appendage (LAA) may be an alternative to endoluminal devices for stroke prevention in patients with atrial fibrillation, but multicenter safety and efficacy data in high-risk patients with contraindications to oral anticoagulation are lacking.
  
  
  OBJECTIVE
  The purpose of this study was to report the outcomes of consecutive cases of pericardial suture ligation of the LAA in high-risk patients performed at 4 centers.
  
  
  METHODS
  The cohort included 41 consecutive patients who underwent LAA closure with the LARIAT system. Epicardial and transeptal access was obtained, and the epicardial snare was advanced over an endo-epicardial magnetic-tipped guidewire to close the LAA. Transesophageal echocardiography was used to confirm LAA exclusion.
  
  
  RESULTS
  Mean age was 75 ± 10 years, mean CHADS2 score was 3.0 ± 1.3, and mean HAS-BLED score was 4.4 ± 1.4. These patients accumulated 24.6 person-years of follow-up. Acute LAA closure was achieved in 38 patients (93%). Transesophageal echocardiography or computerized tomographic angiography performed up to 3.3 ± 0.8 months after the procedure demonstrated LAA leakage in 24% of patients. One patient (2%) had a transient ischemic attack, and 8 (20%) developed pericardial effusions requiring pericardiocentesis. Four cases (9%) were complicated by perforation of the LAA, with 2 of these patients requiring open surgical correction.
  
  
  CONCLUSIONS
  This multicenter experience revealed that pericardial suture ligation with the LARIAT system is technically feasible and acutely efficacious. However, additional improvements are required to minimize the rate of pericardial complications. A randomized study is warranted to accurately define the long-term efficacy and safety profile of percutaneous epicardial suture ligation.
authors: Helmsley Electrophysiology Center, Mount Sinai School of Medicine, New York, New York.
authors: Marc A
authors: MA
authors: Miller
authors: Helmsley Electrophysiology Center, Mount Sinai School of Medicine, New York, New York.
authors: Sandeep R
authors: SR
authors: Gangireddy
authors: Pacific Heart Institute, Santa Monica, California.
authors: Shephal K
authors: SK
authors: Doshi
authors: Regional Cardiology Associates, Mercy Heart and Vascular Institute, Sacramento, California.
authors: Arash
authors: A
authors: Aryana
authors: Helmsley Electrophysiology Center, Mount Sinai School of Medicine, New York, New York.
authors: Jacob S
authors: JS
authors: Koruth
authors: Helmsley Electrophysiology Center, Mount Sinai School of Medicine, New York, New York.
authors: Susie
authors: S
authors: Sennhauser
authors: Helmsley Electrophysiology Center, Mount Sinai School of Medicine, New York, New York.
authors: Andre
authors: A
authors: d'Avila
authors: Helmsley Electrophysiology Center, Mount Sinai School of Medicine, New York, New York.
authors: Srinivas R
authors: SR
authors: Dukkipati
authors: Cardiology Department, Homolka Hospital, Prague, Czech Republic.
authors: Petr
authors: P
authors: Neuzil
authors: Helmsley Electrophysiology Center, Mount Sinai School of Medicine, New York, New York. Electronic address: vivek.reddy@mountsinai.org.
authors: Vivek Y
authors: VY
authors: Reddy
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020517:Atrial Appendage / Q000000981:diagnostic imaging / Q000601:surgery*; D001281:Atrial Fibrillation / Q000000981:diagnostic imaging / Q000601:surgery*; D017023:Coronary Angiography; D017548:Echocardiography, Transesophageal; D005260:Female; D006801:Humans; D008026:Ligation; D008297:Male; D008875:Middle Aged; D061214:Patient Safety; D011183:Postoperative Complications; D012189:Retrospective Studies; D013536:Suture Techniques / Q000295:instrumentation*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
keywords: Atrial fibrillation; LARIAT; Left atrial appendage; Stroke