title: Val158Met polymorphism of COMT gene and Parkinson's disease risk in Asians.
abstract: In previous study, we have found the catechol-O-methyltransferase (COMT) Val158Met polymorphism as an associated risk factor for Parkinson's disease (PD) in Asian rather than Caucasian populations. The aim of this study was to further evaluate the associations of PD risk with COMT polymorphisms in different Asian populations. We carried out a retrieval of studies that investigated associations between COMT Val158Met polymorphism and PD risk in Asians, and included the study if it met the eligibility criteria. Stata version 12.0 was used to analyze the data. A total of 13 studies including 1,834 patients and 2,298 controls were included. The overall result indicated that COMT Val158Met polymorphism was significantly associated with the risk of PD in Asians (AA vs others: OR = 1.58, 95 % CI 1.26-1.97, p < 0.001; GG vs AA: OR = 0.63, 95 % CI 0.47-0.85, p = 0.002; AA vs GA: OR = 1.58, 95 % CI 1.24-2.00, p < 0.001). In Japanese population, the homozygote AA tends to increase the risk of PD (AA vs others: OR = 1.54, 95 % CI 1.10-2.15, p = 0.012; AA vs GA: OR = 1.61, 95 % CI 1.14-2.29, p = 0.008). This study showed that the Val158Met polymorphism of COMT gene may be associated with PD in Japanese rather than Chinese population. Further studies are needed to confirm this association in more ethnicities.
authors: Department of Physiology, Kunming Medical University, No. 1168 West Chunrong Road, Yuhua Avenue, Chenggong District, Kunming, 650500, Yunnan, People's Republic of China.
authors: Lixue
authors: L
authors: Chuan
authors: Jie
authors: J
authors: Gao
authors: Yuying
authors: Y
authors: Lei
authors: Raoxiang
authors: R
authors: Wang
authors: Lechun
authors: L
authors: Lu
authors: Xianyu
authors: X
authors: Zhang
mesh_terms: D044466:Asian People / Q000235:genetics*; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D002681:China; D020022:Genetic Predisposition to Disease; D006801:Humans; D007564:Japan; D010300:Parkinson Disease / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*; D011110:Polymorphism, Genetic; D012306:Risk
chemical_list: C588010:COMT protein, human; D002394:Catechol O-Methyltransferase