title: Diaporine, a novel endophyte-derived regulator of macrophage differentiation.
abstract: Diaporine (1), an unprecedented symmetric polyketide, was characterized from the endophytic fungus. The structure was determined by extensive spectroscopic analyses. Diaporine can inhibit significantly the differentiation of macrophages and has potential to induce conversion from the M2 to the M1 phenotype, in addition to regulation of the TLR4-MAPK signal pathway and PPARγ activity.
authors: State Key Laboratory of Pharmaceutical Biotechnology, and Model Animal Research Center (MARC), Nanjing University, Nanjing 210093, P. R. China. rxtan@nju.edu.cn ppshen@nju.edu.cn.
authors: Hao Chen
authors: HC
authors: Wu
authors: Hui Ming
authors: HM
authors: Ge
authors: Le Yun
authors: le Y
authors: Zang
authors: Yun Cheng
authors: YC
authors: Bei
authors: Zhi Yuan
authors: ZY
authors: Niu
authors: Wei
authors: W
authors: Wei
authors: Xiu Jing
authors: XJ
authors: Feng
authors: Sen
authors: S
authors: Ding
authors: Seik Weng
authors: SW
authors: Ng
authors: Ping Ping
authors: PP
authors: Shen
authors: Ren Xiang
authors: RX
authors: Tan
mesh_terms: D000818:Animals; D001685:Biological Factors; D002454:Cell Differentiation / Q000187:drug effects*; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D060026:Endophytes / Q000737:chemistry*; D005658:Fungi / Q000737:chemistry*; D005786:Gene Expression Regulation; D048670:MAP Kinase Kinase 4 / Q000235:genetics / Q000378:metabolism; D008264:Macrophages / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D019950:Mitogen-Activated Protein Kinase 1 / Q000235:genetics / Q000378:metabolism; D048052:Mitogen-Activated Protein Kinase 3 / Q000235:genetics / Q000378:metabolism; D047495:PPAR gamma / Q000235:genetics / Q000378:metabolism; D010641:Phenotype; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D061251:Primary Cell Culture; D043982:Rhizophoraceae / Q000382:microbiology; D015398:Signal Transduction; D013559:Symbiosis; D051197:Toll-Like Receptor 4 / Q000235:genetics / Q000378:metabolism
chemical_list: D001685:Biological Factors; D002867:Chromones; D016207:Cytokines; D047495:PPAR gamma; D061065:Polyketides; C493487:Tlr4 protein, mouse; D051197:Toll-Like Receptor 4; C000597741:diaporine; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3; D048670:MAP Kinase Kinase 4