title: Investigation of the effects of propofol and vitamin C administration on erythrocyte deformability in rats with streptozotocin-induced diabetes mellitis.
abstract: OBJECTIVE
  In the current study we aim to investigate the effects of vitamin C and profol on red blood cell deformability in diabetic rats.
  
  
  METHODS
  Twenty- eight Wistar Albino rats were included in the study after streptozocin (60 mg/kg) treatment for 4 weeks of observation for diabetes presence. Twenty-eight rats were allocated to 4 groups. In group DP (n = 7) 150 mg.kg-1 of propofol was injected intraperitoneally. In group DP-vit C (n = 7) rats 100 mg/kg of vitamin C (Ascorbic acid, Redoxon® 1000 mg/5 mL - Roche) were applied one hour before administrating 150 mg.kg-1 of propofol, while rats in control group (n = 7), and diabetic control group (n = 7) received intraperitoneally physiological saline. Deformability measurements were achieved by using erythrocyte suspensions with hematocrit level of 5 % in PBS buffer.
  
  
  RESULTS
  Erythrocyte deformability was significantly higher in diabetic control group than in control and vitamin C plus propofol groups (p = 0.00, p = 0.025, respectively). Erythrocyte deformability indexes were found similar in control group and vitamin C plus propofol group (p = 0.949). Relative resistance was increased in diabetic rat model.
  
  
  CONCLUSIONS
  Erythrocyte deformability was damaged in rats with diabetes. This injury might lead to further problems in microcirculation. Application of propofol did not alter red cell deformability in diabetic rats. Vitamin C supplementation seems to reverse those negative effects and variations in erythrocyte deformability (Fig. 2, Ref. 57).
authors: F M
authors: FM
authors: Comu
authors: L
authors: L
authors: Ozturk
authors: M
authors: M
authors: Alkan
authors: K
authors: K
authors: Pampal
authors: M
authors: M
authors: Arslan
authors: B
authors: B
authors: Isik
authors: M S
authors: MS
authors: Atac
authors: D
authors: D
authors: Yilmaz
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000139:chemically induced / Q000188:drug therapy*; D004907:Erythrocyte Deformability / Q000187:drug effects*; D006801:Humans; D008297:Male; D015742:Propofol / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin
chemical_list: D013311:Streptozocin; D001205:Ascorbic Acid; D015742:Propofol