title: Current status of circulating protein biomarkers to aid the early detection of lung cancer.
abstract: Considerable efforts have been undertaken to produce an effective screening method to reduce lung cancer mortality. Imaging tools such as low-dose computed tomography has shown an increase in the detection of early disease and a reduction in the rate of death. This screening modality has, however, several limitations, such as overdiagnosis and a high rate of false positives. Therefore, new screening methods, such as the use of circulating protein biomarkers, have emerged as an option that could complement imaging studies. In this review, current imaging techniques applied to lung cancer screening protocols are presented, as well as up-to-date status of circulating protein biomarker panels that may improve lung cancer diagnosis. Additionally, diverse statistical and artificial intelligence tools applied to the design and optimization of these panels are discussed along with the presentation of two commercially available blood tests recently developed to help detect lung cancer early.
authors: Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco Avenida Normalistas 800, Colonia Colinas de la Normal, 44270, Guadalajara, Jalisco, México.
authors: Carlos Enrique
authors: CE
authors: Hirales Casillas
authors: José Miguel
authors: JM
authors: Flores Fernández
authors: Eduardo
authors: E
authors: Padilla Camberos
authors: Enrique J
authors: EJ
authors: Herrera López
authors: Gisela
authors: G
authors: Leal Pacheco
authors: Moisés
authors: M
authors: Martínez Velázquez
mesh_terms: D015415:Biomarkers / Q000097:blood*; D001798:Blood Proteins; D003952:Diagnostic Imaging / Q000379:methods; D055088:Early Detection of Cancer / Q000379:methods; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000175:diagnosis*; D011933:Reagent Kits, Diagnostic; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; D011933:Reagent Kits, Diagnostic
keywords: blood test; data analysis methods; early detection; high-risk population; lung cancer; multiple biomarker panels; screening