title: Bioinformatic analysis of nematode migration-associated genes identifies novel vertebrate neural crest markers.
abstract: Neural crest cells are highly motile, yet a limited number of genes governing neural crest migration have been identified by conventional studies. To test the hypothesis that cell migration genes are likely to be conserved over large evolutionary distances and from diverse tissues, we searched for vertebrate homologs of genes important for migration of various cell types in the invertebrate nematode and examined their expression during vertebrate neural crest cell migration. Our systematic analysis utilized a combination of comparative genomic scanning, functional pathway analysis and gene expression profiling to uncover previously unidentified genes expressed by premigratory, emigrating and/or migrating neural crest cells. The results demonstrate that similar gene sets are expressed in migratory cell types across distant animals and different germ layers. Bioinformatics analysis of these factors revealed relationships between these genes within signaling pathways that may be important during neural crest cell migration.
authors: Korea Basic Science Institute Chuncheon Center, Chuncheon, Korea.
authors: Seung-Hae
authors: SH
authors: Kwon
authors: Korea Basic Science Institute Chuncheon Center, Chuncheon, Korea.
authors: Ok Kyu
authors: OK
authors: Park
authors: Division of Biology 139-74, California Institute of Technology, Pasadena, California, United States of America.
authors: Shuyi
authors: S
authors: Nie
authors: Department of Systems Immunology, Kangwon National University, Chuncheon, Korea.
authors: Jina
authors: J
authors: Kwak
authors: Department of Molecular Bioscience, College of Biomedical Science, Kangwon National University, Chuncheon, Korea.
authors: Byung Joon
authors: BJ
authors: Hwang
authors: Division of Biology 139-74, California Institute of Technology, Pasadena, California, United States of America.
authors: Marianne E
authors: ME
authors: Bronner
authors: Department of Systems Immunology, Kangwon National University, Chuncheon, Korea; Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Korea.
authors: Yun
authors: Y
authors: Kee
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D017173:Caenorhabditis elegans / Q000166:cytology / Q000196:embryology / Q000235:genetics; D002465:Cell Movement / Q000235:genetics*; D002642:Chick Embryo; D019295:Computational Biology / Q000379:methods*; D004625:Embryo, Nonmammalian / Q000196:embryology / Q000378:metabolism; D019143:Evolution, Molecular; D020869:Gene Expression Profiling / Q000379:methods; D018507:Gene Expression Regulation, Developmental; D017238:Genes, Helminth / Q000235:genetics*; D023281:Genomics / Q000379:methods; D017403:In Situ Hybridization; D009348:Nematoda / Q000166:cytology / Q000196:embryology / Q000235:genetics*; D009432:Neural Crest / Q000166:cytology / Q000196:embryology / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics; D014714:Vertebrates / Q000196:embryology / Q000235:genetics*
chemical_list: D015415:Biomarkers