title: Candidaemia observed at a university hospital in Milan (northern Italy) and review of published studies from 2010 to 2014.
abstract: BACKGROUND
  Candida species represent the fourth leading cause of nosocomial bloodstream infections (BSI) worldwide. However, candidaemia rates and species involved vary geographically.
  
  
  OBJECTIVE
  To evaluate the epidemiological pattern, risk factors for mortality and antifungal therapy of Candida BSI over a 5-year period (2008-2012) in a university hospital in northern Italy together with a review of the recent literature concerning candidaemia.
  
  
  METHODS
  A retrospective cohort study cross-linked with microbiology database was performed.
  
  
  RESULTS
  A total of 89 Candida BSI were identified in 42 males (47 %) and 47 females (52.8 %). The median age was 69 years (interquartile range 55-78) with 61.8 % of patients being older than 65 years. Considering all hospitalized patients, the overall incidence rate of candidaemia increased significantly from 2008 to 2012 (from 0.4 to 1.68 episodes per 10,000 patient/days) (p = 0.0001) with a mean linear increase in 5 new cases per year. Candida albicans was the predominant species isolated (64 %) followed by C. glabrata (19.1 %). The latter species was observed with significantly higher frequency in Internal Medicine and Intensive Care Units (ICU). In-hospital crude mortality was 41.6 %.
  
  
  CONCLUSIONS
  Candidaemia is an increasing BSI in our university hospital, in accordance with that observed in northern Italy, and it is still associated with high in-hospital crude mortality.
authors: III Division of Infectious Diseases, Department of Biomedical and Clinical Sciences L. Sacco, Luigi Sacco Hospital, University of Milan, Via G.B. Grassi 74, 20157, Milan, Italy, laura.milazzo@unimi.it.
authors: Laura
authors: L
authors: Milazzo
authors: Anna Maria
authors: AM
authors: Peri
authors: Cristina
authors: C
authors: Mazzali
authors: Romualdo
authors: R
authors: Grande
authors: Chiara
authors: C
authors: Cazzani
authors: Davide
authors: D
authors: Ricaboni
authors: Antonio
authors: A
authors: Castelli
authors: Ferdinando
authors: F
authors: Raimondi
authors: Carlo
authors: C
authors: Magni
authors: Massimo
authors: M
authors: Galli
authors: Spinello
authors: S
authors: Antinori
mesh_terms: D000368:Aged; D002175:Candida / Q000145:classification* / Q000302:isolation & purification; D058387:Candidemia / Q000453:epidemiology* / Q000382:microbiology* / Q000401:mortality; D015331:Cohort Studies; D005260:Female; D006785:Hospitals, University; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis