title: Assessment of long-term health risks after accidental exposure using haemoglobin adducts of epichlorohydrin.
abstract: On September 9th, 2002, two goods trains collided in Bad Münder, Lower Saxony, causing the release of more than 40 metric tonnes of epichlorohydrin (1-chloro-2,3-epoxypropane) into the environment. A human biomonitoring study was performed to evaluate the accidental exposure to epichlorohydrin and to assess the possible long-term, i.e. carcinogenic health effects. This was done on the basis of a biochemical effect monitoring using the N-(3-chloro-2-hydroxypropyl)valine and the N-(2,3-dihydroxypropyl)valine haemoglobin adducts of epichlorohydrin in blood to respond to missing ambient monitoring immediately after the crash. N-(3-chloro-2-hydroxypropyl)valine adduct levels above the LOQ (25 pmol/g globin) ranged from 32.0 to 116.4 pmol/g globin in 6 out of 628 samples. The N-(2,3-dihydroxypropyl)valine adduct was not detected above the LOD (10 pmol/g globin) in any of the blood samples. Based on the quantified N-(3-chloro-2-hydroxypropyl)valine adduct values, the body doses after two days of exposure were estimated to be in the range of 1.7-6.2 nmol/kg body weight. The reverse estimation of the external exposure leads to cumulative additional lifetime cancer risks ranging from 2.61×10(-8) to 9.48×10(-8). The estimated excess lifetime cancer risks have to be assessed as extremely low. Our biomonitoring study facilitated the dialogue between individuals and groups concerned and authorities, because suspected or occurred exposures and risks to human health could be quantified and interpreted in a sound manner.
authors: Lower Saxony Governmental Institute of Public Health, Roesebeckstr. 4-6, 30 449 Hannover, Germany. Electronic address: klaus-michael.wollin@nlga.niedersachsen.de.
authors: Klaus-Michael
authors: KM
authors: Wollin
authors: Institute of Occupational Medicine, Hannover Medical School, Hannover, Germany.
authors: Michael
authors: M
authors: Bader
authors: Institute of Occupational, Social and Environmental Medicine, University Medical Centre, Göttingen, Germany.
authors: Michael
authors: M
authors: Müller
authors: Lower Saxony State Agency for Ecology, Hannover/Hildesheim, Germany.
authors: Werner
authors: W
authors: Lilienblum
authors: Ministry for Social Affairs, Health and Equal Opportunities, Germany.
authors: Michael
authors: M
authors: Csicsaky
mesh_terms: D055884:Chemical Hazard Release; D060731:Emergency Responders; D004784:Environmental Monitoring / Q000379:methods*; D004811:Epichlorohydrin / Q000097:blood* / Q000506:poisoning*; D005858:Germany; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D019570:Inhalation Exposure / Q000009:adverse effects*; D012306:Risk; D014633:Valine / Q000031:analogs & derivatives / Q000097:blood
chemical_list: D006454:Hemoglobins; C416044:N-(2,3-dihydroxypropyl)valine; D004811:Epichlorohydrin; D014633:Valine
keywords: Accidental exposure; Epichlorohydrine; Human biomonitoring; Risk assessment