title: Pathway landscapes and epigenetic regulation in breast cancer and melanoma cell lines.
abstract: BACKGROUND
  Epigenetic variation is a main regulation mechanism of gene expression in various cancer histotypes, and due to its reversibility, the potential impact in therapy can be very relevant.
  
  
  METHODS
  Based on a selected pair, breast cancer (BC) and melanoma, we conducted inference analysis in parallel on a few cell lines (MCF-7 for BC and A375 for melanoma). Starting from differential expression after treatment with a demethylating agent, the 5-Aza-2'-deoxycytidine (DAC), we provided pathway enrichment analysis and gene regulatory maps with cross-linked microRNAs and transcription factors.
  
  
  RESULTS
  Several oncogenic signaling pathways altered upon DAC treatment were detected with significant enrichment. We represented the association between these cancers by depicting the landscape of common and specific variation affecting them.
authors: Mariama
authors: M
authors: El Baroudi
authors: Dario
authors: D
authors: La Sala
authors: Caterina
authors: C
authors: Cinti
authors: Enrico
authors: E
authors: Capobianco
mesh_terms: D001374:Azacitidine / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000235:genetics*; D045744:Cell Line, Tumor; D000077209:Decitabine; D015536:Down-Regulation / Q000187:drug effects / Q000235:genetics; D044127:Epigenesis, Genetic / Q000187:drug effects; D005260:Female; D053263:Gene Regulatory Networks / Q000187:drug effects; D052138:Genes, Neoplasm; D006801:Humans; D008545:Melanoma / Q000188:drug therapy / Q000235:genetics*; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics*; D014158:Transcription, Genetic / Q000187:drug effects; D015854:Up-Regulation / Q000187:drug effects / Q000235:genetics
chemical_list: D000077209:Decitabine; D001374:Azacitidine