title: Multiple roles of toll-like receptor 4 in colorectal cancer.
abstract: Toll-like receptor (TLR) signaling has been implicated in the inflammatory responses in intestinal epithelial cells (IECs). Such inflammatory signals mediate complex interactions between commensal bacteria and TLRs and are required for IEC proliferation, immune response, repair, and homeostasis. The upregulation of certain TLRs in colorectal cancer (CRC) tissues suggests that TLRs may play an essential role in the prognosis of chronic and inflammatory diseases that ultimately culminate in CRC. Here, we provide a comprehensive review of the literature on the involvement of the TLR pathway in the initiation, progression, and metastasis of CRC, as well as inherited genetic variation and epigenetic regulation. The differential expression of TLRs in epithelial cells has also been discussed. In particular, we emphasize the physiological role of TLR4 in CRC development and pathogenesis, and propose novel and promising approaches for CRC therapeutics with the aid of TLR ligands.
authors: Department of Molecular Science and Technology, Ajou University , Suwon , South Korea.
authors: Dhanusha
authors: D
authors: Yesudhas
authors: Department of Molecular Science and Technology, Ajou University , Suwon , South Korea.
authors: Vijayakumar
authors: V
authors: Gosu
authors: Department of Molecular Science and Technology, Ajou University , Suwon , South Korea.
authors: Muhammad Ayaz
authors: MA
authors: Anwar
authors: Department of Molecular Science and Technology, Ajou University , Suwon , South Korea.
authors: Sangdun
authors: S
authors: Choi
keywords: colorectal cancer; immune response; inflammation; ligand; toll-like receptor 4