title: Placental pathologies on fetal MRI are associated with high impairment rates: a prospective long-term outcome study.
abstract: OBJECTIVE
  Placental anomalies visualized at midgestation by MRI are shown to be related to pregnancy outcome. We performed a prospective cohort study to investigate the influence of placental pathologies diagnosed with fetal MRI on long-term neurodevelopmental outcome.
  
  
  METHODS
  In our hospital-based, cross-sectional study, all fetal MRI examinations of pregnancies with vascular placental pathology (i.e. infarction with/without hemorrhage, subchorionic thrombi/hemorrhages, intervillous thrombi/hemorrhages or retroplacental hematoma) between 2003 and 2007 were included. The extent of the pathology was expressed as the percentage of abnormality related to the whole placental volume. Pathohistological reports were correlated to MRI findings. Infants were prospectively investigated using Bayley developmental scales at the age of 2-3.5 years. Impairment was categorized as a Bayley scale two SDs below normal (<85 points).
  
  
  RESULTS
  There were 31 singletons and 25 offspring of multiple pregnancies included in the analyses. Impairment rates were 32.2% in singletons and 32.0% in multiple births. No correlation between neuro/motor developmental outcome at 2-3.5 years and the type, extent or gestational week at the time of diagnoses of placental vascular pathologies was found.
  
  
  CONCLUSIONS
  The long-term outcome of children with vascular placental pathologies on fetal MRI was associated with a high impairment rate after 2-3.5 years, both on motor- and neurodevelopmental Bayley scales. Neurological impairment did not correlate with the extent of placental involvement, intrauterine growth restriction, gestational age at birth or multiple state.
authors: a Department of Pediatrics and Adolescent Medicine .
authors: Nina
authors: N
authors: Linduska
authors: Antonia
authors: A
authors: Knoezinger
authors: Sabine
authors: S
authors: Dekan
authors: Michael
authors: M
authors: Weber
authors: Michael
authors: M
authors: Hayde
authors: Daniela
authors: D
authors: Prayer
authors: Agnes
authors: A
authors: Grill
mesh_terms: D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D005317:Fetal Growth Retardation / Q000473:pathology*; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D017063:Outcome Assessment, Health Care; D010920:Placenta / Q000473:pathology*; D010922:Placenta Diseases / Q000175:diagnosis*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies
keywords: Neonatal; outcome; pathology; placenta