title: Cysteine-selective reactions for antibody conjugation.
abstract: Moving tracks from maleimide: New site-selective protein modification reactions at cysteine have been developed. Unlike conventional maleimide conjugation, which results in a labile thioether succinimide, the new bioconjugation reactions result in stable conjugates and provide opportunities to develop a new generation of homogeneous, stable, and therapeutically useful conjugates.
authors: Instituto de Investigação do Medicamento (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa (Portugal) http://www.ff.ul.pt/∼pedrogois/index.html.
authors: Pedro M S D
authors: PM
authors: Cal
authors: Gonçalo J L
authors: GJ
authors: Bernardes
authors: Pedro M P
authors: PM
authors: Gois
mesh_terms: D003545:Cysteine / Q000737:chemistry*; D006801:Humans; D010069:Oxadiazoles / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D010069:Oxadiazoles; D011506:Proteins; D013438:Sulfhydryl Compounds; D003545:Cysteine
keywords: antibodies; bioorganic chemistry; conjugation; drug delivery; maleimides