title: [Implementation of ontology-based clinical decision support system for management of interactions between antihypertensive drugs and diet].
abstract: OBJECTIVE
  The influence of dietary composition on blood pressure is an important subject in healthcare. Interactions between antihypertensive drugs and diet (IBADD) is the most important factor in the management of hypertension. It is therefore essential to support healthcare providers' decision making role in active and continuous interaction control in hypertension management. The aim of this study was to implement an ontology-based clinical decision support system (CDSS) for IBADD management (IBADDM). We considered the concepts of antihypertensive drugs and foods, and focused on the interchangeability between the database and the CDSS when providing tailored information.
  
  
  METHODS
  An ontology-based CDSS for IBADDM was implemented in eight phases: (1) determining the domain and scope of ontology, (2) reviewing existing ontology, (3) extracting and defining the concepts, (4) assigning relationships between concepts, (5) creating a conceptual map with CmapTools, (6) selecting upper ontology, (7) formally representing the ontology with Protégé (ver.4.3), (8) implementing an ontology-based CDSS as a JAVA prototype application.
  
  
  RESULTS
  We extracted 5,926 concepts, 15 properties, and formally represented them using Protégé. An ontology-based CDSS for IBADDM was implemented and the evaluation score was 4.60 out of 5.
  
  
  CONCLUSIONS
  We endeavored to map functions of a CDSS and implement an ontology-based CDSS for IBADDM.
authors: College of Nursing, Kyungpook National University, Daegu, Korea.
authors: Jeong Eun
authors: JE
authors: Park
authors: Department of Medical Information Technology, Daegu Haany University, Daegu, Korea.
authors: Hwa Sun
authors: HS
authors: Kim
authors: Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Seoul, Korea.
authors: Min Jung
authors: MJ
authors: Chang
authors: College of Nursing, Kyungpook National University, Daegu, Korea. hshong@knu.ac.kr.
authors: Hae Sook
authors: HS
authors: Hong
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D064229:Biological Ontologies; D016208:Databases, Factual; D020000:Decision Support Systems, Clinical; D004032:Diet; D004347:Drug Interactions; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D012984:Software
chemical_list: D000959:Antihypertensive Agents
keywords: Clinical decision support system (CDSS); Interactions between antihypertensive drug and diet; Ontology