title: Targeting potassium channels in cancer.
abstract: Potassium channels are pore-forming transmembrane proteins that regulate a multitude of biological processes by controlling potassium flow across cell membranes. Aberrant potassium channel functions contribute to diseases such as epilepsy, cardiac arrhythmia, and neuromuscular symptoms collectively known as channelopathies. Increasing evidence suggests that cancer constitutes another category of channelopathies associated with dysregulated channel expression. Indeed, potassium channel-modulating agents have demonstrated antitumor efficacy. Potassium channels regulate cancer cell behaviors such as proliferation and migration through both canonical ion permeation-dependent and noncanonical ion permeation-independent functions. Given their cell surface localization and well-known pharmacology, pharmacological strategies to target potassium channel could prove to be promising cancer therapeutics.
authors: Howard Hughes Medical Institute, Department of Physiology, and Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158Howard Hughes Medical Institute, Department of Physiology, and Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158Howard Hughes Medical Institute, Department of Physiology, and Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158 xi.huang@ucsf.edu lily.jan@ucsf.edu.
authors: Xi
authors: X
authors: Huang
authors: Howard Hughes Medical Institute, Department of Physiology, and Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158Howard Hughes Medical Institute, Department of Physiology, and Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158Howard Hughes Medical Institute, Department of Physiology, and Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158 xi.huang@ucsf.edu lily.jan@ucsf.edu.
authors: Lily Yeh
authors: LY
authors: Jan
mesh_terms: D002453:Cell Cycle; D002465:Cell Movement; D049109:Cell Proliferation; D006801:Humans; D008954:Models, Biological; D009362:Neoplasm Metastasis / Q000235:genetics / Q000473:pathology / Q000628:therapy; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D026902:Potassium Channel Blockers / Q000627:therapeutic use; D015221:Potassium Channels / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D059016:Tumor Microenvironment
chemical_list: D026902:Potassium Channel Blockers; D015221:Potassium Channels