title: Photocatalytic decarboxylative reduction of carboxylic acids and its application in asymmetric synthesis.
abstract: The decarboxylative reduction of naturally abundant carboxylic acids such as α-amino acids and α-hydroxy acids has been achieved via visible-light photoredox catalysis. By using an organocatalytic photoredox system, this method offers a mild and rapid entry to a variety of high-value compounds including medicinally relevant scaffolds. Regioselective decarboxylation is achieved when differently substituted dicarboxylic acids are employed. The application of this method to the synthesis of enantioenriched 1-aryl-2,2,2-trifluoroethyl chiral amines starting from natural α-amino acids further testifies to the utility of the developed photocatalytic decarboxylative reduction protocol.
authors: Department of Chemistry and Molecular Biology, Gothenburg University , SE-412 58, Gothenburg, Sweden.
authors: Carlo
authors: C
authors: Cassani
authors: Giulia
authors: G
authors: Bergonzini
authors: Carl-Johan
authors: CJ
authors: Wallentin
mesh_terms: D000588:Amines / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry*; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D003653:Decarboxylation; D015394:Molecular Structure; D010084:Oxidation-Reduction; D055668:Photochemical Processes
chemical_list: D000588:Amines; D000596:Amino Acids; D001688:Biological Products; D002264:Carboxylic Acids