title: Branching angles of pyramidal cell dendrites follow common geometrical design principles in different cortical areas.
abstract: Unraveling pyramidal cell structure is crucial to understanding cortical circuit computations. Although it is well known that pyramidal cell branching structure differs in the various cortical areas, the principles that determine the geometric shapes of these cells are not fully understood. Here we analyzed and modeled with a von Mises distribution the branching angles in 3D reconstructed basal dendritic arbors of hundreds of intracellularly injected cortical pyramidal cells in seven different cortical regions of the frontal, parietal, and occipital cortex of the mouse. We found that, despite the differences in the structure of the pyramidal cells in these distinct functional and cytoarchitectonic cortical areas, there are common design principles that govern the geometry of dendritic branching angles of pyramidal cells in all cortical areas.
authors: Computational Intelligence Group, Departamento de Inteligencia Artificial, Universidad Politécnica de Madrid, Campus de Montegancedo, Boadilla del Monte, 28660 Madrid, Spain.
authors: Concha
authors: C
authors: Bielza
authors: 1] Instituto Cajal (CSIC), Ave. Dr. Arce, 37, 28002 Madrid, Spain [2] Laboratorio Cajal de Circuitos Corticales, Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, Campus de Montegancedo, Pozuelo de Alarcón, 28223 Madrid, Spain.
authors: Ruth
authors: R
authors: Benavides-Piccione
authors: Computational Intelligence Group, Departamento de Inteligencia Artificial, Universidad Politécnica de Madrid, Campus de Montegancedo, Boadilla del Monte, 28660 Madrid, Spain.
authors: Pedro
authors: P
authors: López-Cruz
authors: Computational Intelligence Group, Departamento de Inteligencia Artificial, Universidad Politécnica de Madrid, Campus de Montegancedo, Boadilla del Monte, 28660 Madrid, Spain.
authors: Pedro
authors: P
authors: Larrañaga
authors: 1] Instituto Cajal (CSIC), Ave. Dr. Arce, 37, 28002 Madrid, Spain [2] Laboratorio Cajal de Circuitos Corticales, Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, Campus de Montegancedo, Pozuelo de Alarcón, 28223 Madrid, Spain.
authors: Javier
authors: J
authors: DeFelipe
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology*; D003712:Dendrites / Q000648:ultrastructure*; D051379:Mice; D017966:Pyramidal Cells / Q000648:ultrastructure*