title: The French-Canadian validation of a disease-specific, patient-reported outcome measure for lupus.
abstract: OBJECTIVE
  The objective of this paper is to perform the cross-cultural validation of the French version of the LupusPRO, a disease-targeted patient-reported outcome measure, among systemic lupus erythematosus (SLE) patients in Canada.
  
  
  METHODS
  The French version of the LupusPRO and the MOS SF-36 were administered; demographic, clinical and serological characteristics were obtained. Disease activity (SELENA-SLEDAI and the Lupus Foundation of America definition of flare) and damage (SLICC/ACR SDI) were assessed. Physician disease activity and damage assessments were ascertained using visual analog scales. Internal consistency reliability (ICR), test-retest reliability (TRT), convergent and discriminant validity (against corresponding domains of the SF-36), criterion validity (against disease activity, damage or health status) and known group validity were tested.
  
  
  RESULTS
  A total of 99 French-Canadian SLE patients participated (97% women, mean (SD) age 45.2 (14.5) years). The median (IQR) SELENA-SLEDAI and SDI were 3.5 (6.0) and 1.0 (2.0), respectively. The ICR of the LupusPRO domains ranged from 0.81 to 0.93 (except for lupus symptoms, procreation and coping), while TRT ranged from 0.72 to 0.95. Convergent and discriminant validity, criterion validity and known group validity against disease activity, damage and health status measures were observed. Confirmatory factor analysis showed a good fit.
  
  
  CONCLUSIONS
  The LupusPRO has fair psychometric properties among French-Canadian patients with SLE.
authors: Department of Medicine, Division of Rheumatology, University of Montreal Health Center, Canada.
authors: J
authors: J
authors: Bourré-Tessier
authors: Department of Medicine, Division of Rheumatology, University of Calgary, Canada.
authors: A E
authors: AE
authors: Clarke
authors: QualityMetric Inc, Outcomes Insight Consulting Division, USA.
authors: M
authors: M
authors: Kosinski
authors: Department of Medicine, Division of Rheumatology, Rush University Medical Center, USA.
authors: R A
authors: RA
authors: Mikolaitis-Preuss
authors: Department of Medicine, Division of Rheumatology, McGill University Health Centre, Canada Department of Medicine, Division of Clinical Epidemiology, McGill University Health Centre, McGill University, Canada.
authors: S
authors: S
authors: Bernatsky
authors: Department of Medicine, Division of Rheumatology, Rush University Medical Center, USA.
authors: J A
authors: JA
authors: Block
authors: Department of Medicine, Division of Rheumatology, Rush University Medical Center, USA Meenakshi_Jolly@rush.edu.
authors: M
authors: M
authors: Jolly
mesh_terms: D000328:Adult; D001828:Body Image; D002170:Canada; D003071:Cognition; D004644:Emotions; D005260:Female; D006040:Goals; D006304:Health Status; D006801:Humans; D007802:Language; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000523:psychology; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000209:etiology; D063868:Patient Outcome Assessment; D011594:Psychometrics; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires
keywords: Systemic lupus erythematosus; quality of life; self-assessment