title: Synthesis of methylprednisolone loaded ibuprofen modified inulin based nanoparticles and their application for drug delivery.
abstract: Ibuprofen modified inulin was synthesized through a direct esterification linkage in which the in situ activation of the carboxylic acid with N,N'-carbonyldiimidazole was carried out. The critical aggregation concentration of the ibuprofen modified inulin was determined by using pyrene as the fluorescence probe. Methylprednisolone loaded nanoparticles were prepared by the self-assembly of the ibuprofen modified inulin copolymer and methylprednisolone. In vitro release of the methylprednisolone and the cytotoxicity of the methylprednisolone loaded nanoparticles against RSC-96 cells were evaluated. Since the ibuprofen and methylprednisolone could stimulate a significant neurite growth and diminish the human neurological deficits after the spinal cord injury, the methylprednisolone loaded nanoparticles based on the ibuprofen modified inulin copolymer may have a great potential in the synergetic effect treatment for spinal cord injury.
authors: Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong 226001, PR China.
authors: Luzhong
authors: L
authors: Zhang
authors: School of Education Science, Nantong University, Nantong 226001, PR China.
authors: Yue
authors: Y
authors: Li
authors: Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong 226001, PR China.
authors: Caiping
authors: C
authors: Wang
authors: Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong 226001, PR China.
authors: Guicai
authors: G
authors: Li
authors: Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong 226001, PR China.
authors: Yahong
authors: Y
authors: Zhao
authors: Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong 226001, PR China. Electronic address: yangym@ntu.edu.cn.
authors: Yumin
authors: Y
authors: Yang
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry* / Q000633:toxicity; D007052:Ibuprofen / Q000737:chemistry*; D007444:Inulin / Q000737:chemistry*; D008775:Methylprednisolone / Q000737:chemistry* / Q000493:pharmacokinetics / Q000633:toxicity; D053758:Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D010316:Particle Size; D051381:Rats
chemical_list: D004337:Drug Carriers; D007444:Inulin; D007052:Ibuprofen; D008775:Methylprednisolone
keywords: Drug delivery; Ibuprofen; Inulin; Methylprednisolone; Nanoparticle