title: Effect of resveratrol on behavioral performance of streptozotocin-induced diabetic mice in anxiety tests.
abstract: The aim of this study was to evaluate with anxiety tests the effect of resveratrol (RSV) on streptozotocin (STZ)-induced diabetic mouse behavioral performance at the second and fourth week of treatment. Confirmed diabetic mice (>250 mg/dl of glucose in blood after STZ injection) were treated with RSV (RDM, n=12) or control treated (DM, n=12) for 4 weeks. DM and RDM were tested in the Open Field Test (OFT) and Elevated Plus Maze (EPM). In the second week of RSV treatment, a higher grooming frequency (P<0.05) and a lower defecation and rearing frequency (P<0.05) were detected in the OFT in the RDM group compared with the DM. There was a higher grooming frequency (P<0.05) and higher percentage of entries in open arms (P<0.05) in the RDM group than in the DM group in the EPM. However, in the fourth week of RSV treatment, the only effect observed was a higher grooming frequency in the RDM group than in the DM group (P<0.05) in the EPM. In conclusion, RSV treatment in diabetic mice provoked anxiolytic-like effects in both tests (OFT and EPM), and these effects were observed in a short time window (2 weeks). It is suggested that RSV may help diabetic animals to adapt to new stressing and anxiety situations and thus to improve their welfare.
authors: Laboratorio de Señalización Celular y Nanobiología, Instituto de Investigaciones Biológicas Clemente Estable (IIBCE), Av. Italia 3318, 11600 Montevideo, Uruguay.
authors: Juan P
authors: JP
authors: Damián
authors: Victoria
authors: V
authors: Acosta
authors: Maira
authors: M
authors: Da Cuña
authors: Isara
authors: I
authors: Ramírez
authors: Natalia
authors: N
authors: Oddone
authors: Ana
authors: A
authors: Zambrana
authors: Verónica
authors: V
authors: Bervejillo
authors: Juan C
authors: JC
authors: Benech
mesh_terms: D000223:Adaptation, Psychological / Q000187:drug effects; D000818:Animals; D014151:Anti-Anxiety Agents; D016588:Anticarcinogenic Agents; D000975:Antioxidants; D001007:Anxiety / Q000523:psychology*; D001522:Behavior, Animal / Q000187:drug effects*; D003672:Defecation / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000523:psychology*; D006120:Grooming / Q000187:drug effects; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage / Q000494:pharmacology*; D013311:Streptozocin; D013997:Time Factors; D014554:Urination / Q000187:drug effects
chemical_list: D014151:Anti-Anxiety Agents; D016588:Anticarcinogenic Agents; D000975:Antioxidants; D013267:Stilbenes; D013311:Streptozocin; D000077185:Resveratrol