title: Modulation of dendritic cell functions by viral IL-10 encoded by human cytomegalovirus.
abstract: Human cytomegalovirus (HCMV), a clinically important β-herpesvirus, is a master of evasion and modulation of the host immune system, including inhibition of a number of dendritic cell (DC) functions. DCs play a central role in co-ordination of the immune response against pathogens and any disturbance of DCs functions can result in a cascade effect on a range of immune cells. Recently, the HCMV gene UL111A, which encodes viral homologs of human interleukin 10, has been identified as a strong suppressor of a number of DCs functions. In this mini review, we focus on HCMV-encoded viral IL-10-mediated inhibitory effects on DCs and implications for the development of an effective HCMV vaccine.
authors: Human Cytomegalovirus Research Group, Discipline of Infectious Diseases and Immunology, University of Sydney Camperdown, NSW, Australia.
authors: Selmir
authors: S
authors: Avdic
authors: Human Cytomegalovirus Research Group, Discipline of Infectious Diseases and Immunology, University of Sydney Camperdown, NSW, Australia.
authors: Brian P
authors: BP
authors: McSharry
authors: Human Cytomegalovirus Research Group, Discipline of Infectious Diseases and Immunology, University of Sydney Camperdown, NSW, Australia ; Centre for Virus Research, Westmead Millennium Institute Westmead, NSW, Australia.
authors: Barry
authors: B
authors: Slobedman
keywords: cytomegalovirus; dendritic cells; immunomodulation; interleukin 10; virus replication and latency