title: Nanotechnology in drug delivery: the need for more cell culture based studies in screening.
abstract: Advances in biomedical science are leading to upsurge synthesis of nanodelivery systems for drug delivery. The systems were characterized by controlled, targeted and sustained drug delivery ability. Humans are the target of these systems, hence, animals whose systems resembles humans were used to predict outcome. Thus, increasing costs in money and time, plus ethical concerns over animal usage. However, with consideration and planning in experimental conditions, in vitro pharmacological studies of the nanodelivery can mimic the in vivo system. This can function as a simple method to investigate the effect of such materials without endangering animals especially at screening phase.
authors: Laboratory of Vaccine and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, 43400 Selangor, Malaysia.
authors: Aminu Umar
authors: AU
authors: Kura
authors: Laboratory of Vaccine and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, 43400 Selangor, Malaysia ; Faculty of Medicine and Health Science, Pharmacology Unit, Universiti Putra Malaysia, Selangor, Malaysia.
authors: Sharida
authors: S
authors: Fakurazi
authors: Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology, Universiti Putra Malaysia, Selangor, Malaysia.
authors: Mohd Zobir
authors: MZ
authors: Hussein
authors: Laboratory of Vaccine and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, 43400 Selangor, Malaysia.
authors: Palanisamy
authors: P
authors: Arulselvan
keywords: Animal studies; In vitro; Nanodelivery system; Toxicity and bio distribution