title: Adult-born granule cells mature through two functionally distinct states.
abstract: Adult-born granule cells (ABGCs) are involved in certain forms of hippocampus-dependent learning and memory. It has been proposed that young but functionally integrated ABGCs (4-weeks-old) specifically contribute to pattern separation functions of the dentate gyrus due to their heightened excitability, whereas old ABGCs (>8 weeks old) lose these capabilities. Measuring multiple cellular and integrative characteristics of 3- 10-week-old individual ABGCs, we show that ABGCs consist of two functionally distinguishable populations showing highly distinct input integration properties (one group being highly sensitive to narrow input intensity ranges while the other group linearly reports input strength) that are largely independent of the cellular age and maturation stage, suggesting that 'classmate' cells (born during the same period) can contribute to the network with fundamentally different functions. Thus, ABGCs provide two temporally overlapping but functionally distinct neuronal cell populations, adding a novel level of complexity to our understanding of how life-long neurogenesis contributes to adult brain function.
authors: Lendület Laboratory of Cellular Neuropharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary János Szentágothai School of Neurosciences, Semmelweis University School of PhD Studies, Budapest, Hungary.
authors: János
authors: J
authors: Brunner
authors: Lendület Laboratory of Cellular Neuropharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary János Szentágothai School of Neurosciences, Semmelweis University School of PhD Studies, Budapest, Hungary.
authors: Máté
authors: M
authors: Neubrandt
authors: Lendület Laboratory of Cellular Neuropharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary.
authors: Susan
authors: S
authors: Van-Weert
authors: Lendület Laboratory of Cellular Neuropharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary János Szentágothai School of Neurosciences, Semmelweis University School of PhD Studies, Budapest, Hungary.
authors: Tibor
authors: T
authors: Andrási
authors: Brain Research Institute, Faculty of Medicine and Science, University of Zurich, Zurich, Switzerland.
authors: Felix B
authors: FB
authors: Kleine Borgmann
authors: Brain Research Institute, Faculty of Medicine and Science, University of Zurich, Zurich, Switzerland jessberger@hifo.uzh.ch.
authors: Sebastian
authors: S
authors: Jessberger
authors: Lendület Laboratory of Cellular Neuropharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary szabadics.janos@koki.mta.hu.
authors: János
authors: J
authors: Szabadics
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D019070:Cell Lineage / Q000502:physiology*; D016922:Cellular Senescence / Q000502:physiology; D018891:Dentate Gyrus / Q000166:cytology / Q000502:physiology*; D004566:Electrodes; D015870:Gene Expression; D017930:Genes, Reporter; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism; D008297:Male; D008568:Memory / Q000502:physiology; D055495:Neurogenesis; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D018408:Patch-Clamp Techniques; D051381:Rats; D017208:Rats, Wistar; D013238:Stereotaxic Techniques; D013569:Synapses / Q000502:physiology
chemical_list: D049452:Green Fluorescent Proteins
keywords: active and passive intrinsic membrane properties; adult neurogenesis; cellular maturation; dentate gyrus; input–output function; pattern separation