title: Intracellular Nef detected in peripheral blood mononuclear cells from HIV patients.
abstract: We report here the novel finding that HIV-negative factor (Nef) protein is present in considerable numbers of peripheral blood mononuclear cells (PBMCs) from viremic HIV-infected patients not on antiretroviral therapy (ART) and also in patients receiving virologically suppressive ART, though to a smaller degree. Interestingly, these Nef-positive PBMCs constitute predominantly uninfected bystander cells. These results may explain systemic pathology in HIV patients, even in those receiving ART.
authors: 1 Department of Microbiology and Immunology, Indiana University School of Medicine , Indianapolis, Indiana.
authors: Ting
authors: T
authors: Wang
authors: Linden A
authors: LA
authors: Green
authors: Samir K
authors: SK
authors: Gupta
authors: Tohti
authors: T
authors: Amet
authors: Daniel J
authors: DJ
authors: Byrd
authors: Qigui
authors: Q
authors: Yu
authors: Homer L
authors: HL
authors: Twigg
authors: Matthias
authors: M
authors: Clauss
mesh_terms: D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D001769:Blood / Q000821:virology*; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000737:chemistry* / Q000821:virology*; D054311:nef Gene Products, Human Immunodeficiency Virus / Q000032:analysis*
chemical_list: D044966:Anti-Retroviral Agents; D054311:nef Gene Products, Human Immunodeficiency Virus; C514837:nef protein, Human immunodeficiency virus 1