title: Diastereoselective synthesis of fused lactone-pyrrolidinones; application to a formal synthesis of (-)-salinosporamide A.
abstract: A mild, diastereoselective synthesis of fused lactone-pyrrolidinones using an oxidative radical cyclization is reported. The methodology is demonstrated in a formal synthesis of (-)-salinosporamide A.
authors: Chemistry Research Laboratory, Department of Chemistry, University of Oxford , Mansfield Road, Oxford OX1 3TA, United Kingdom.
authors: Angus W J
authors: AW
authors: Logan
authors: Simon J
authors: SJ
authors: Sprague
authors: Robert W
authors: RW
authors: Foster
authors: Léo B
authors: LB
authors: Marx
authors: Vincenzo
authors: V
authors: Garzya
authors: Michal S
authors: MS
authors: Hallside
authors: Amber L
authors: AL
authors: Thompson
authors: Jonathan W
authors: JW
authors: Burton
mesh_terms: D003500:Cyclization; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D011760:Pyrrolidinones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D007783:Lactones; D011758:Pyrroles; D011760:Pyrrolidinones; C475865:marizomib