title: MDR1 C3435T polymorphism in Mexican patients with breast cancer.
abstract: We investigated whether the MDR1 C3435T polymorphism is associated with fibrocystic changes (FCC), infiltrating ductal breast cancer (IDBC), and/or clinical-pathological features of IDBC in Mexican patients. Samples from women who received surgical treatment in 2007 at the Centro Médico de Occidente (México) were included in the analysis. Genotyping was performed by polymerase chain reaction-restricted fragment length polymorphisms in 64 paraffin-embedded breast samples with IDBC, 64 samples with FCC, and 183 peripheral blood samples of healthy females designated as the healthy group (HG). The frequency of the T allele was 41, 45, and 52% for the FCC, IDBC, and HG samples, respectively. Significant differences were only found between the FCC and HG samples [odds ratio (OR) = 0.64, 95% confidence interval (CI) = 0.43-0.96; P = 0.032]. The prevalence of the T/T genotype was 8, 13, and 24% for FCC, IDBC, and HG samples, respectively. Again, statistical differences were only found between FCC and HG samples for the T/T genotype (OR = 0.28, 95%CI = 0.106-0.77; P = 0.009). Although the T allele and the T/T genotype were less frequent in the IDBC group than in the HG, the differences were not significant. Furthermore, no associations were found between the C3435T polymorphism and clinical-pathological features of the IDBC group. Both the FCC and IDBC groups had a high frequency of the C allele relative to the HG in this sample of women from Western Mexico.
authors: Departamento de Salud y Bienestar del Centro Universitario del Sur, Universidad de Guadalajara, Guadalajara, Guzmán, Jalisco, México nellymacias_2000@yahoo.com.mx.
authors: N M
authors: NM
authors: Macías-Gómez
authors: Centro Universitario de los Altos, Universidad de Guadalajara, Tepatitlán de Morelos, Jalisco, México.
authors: M
authors: M
authors: Gutiérrez-Angulo
authors: Unidad Académica de Ciencias de la Salud y Tecnología, Universidad Autónoma de Tamaulipas, Matamoros, Tamaulipas, México.
authors: E
authors: E
authors: Leal-Ugarte
authors: Departamento de Salud y Bienestar del Centro Universitario del Sur, Universidad de Guadalajara, Guadalajara, Guzmán, Jalisco, México.
authors: L
authors: L
authors: Ramírez-Reyes
authors: Centro Universitario de Ciencias Biológicas y Agropecuarias, Universidad de Guadalajara, Guadalajara, Jalisco, México.
authors: J
authors: J
authors: Peregrina-Sandoval
authors: Unidad Académica de Ciencias de la Salud y Tecnología, Universidad Autónoma de Tamaulipas, Matamoros, Tamaulipas, México.
authors: J P
authors: JP
authors: Meza-Espinoza
authors: Unidad de Patología, CMNO-IMSS, Guadalajara, Jalisco, México.
authors: F
authors: F
authors: Ramos Solano
authors: Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, México.
authors: M
authors: M
authors: de la Luz Ayala-Madrigal
authors: Departamento de Salud y Bienestar del Centro Universitario del Sur, Universidad de Guadalajara, Guadalajara, Guzmán, Jalisco, México.
authors: F
authors: F
authors: Santoyo Telles
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000235:genetics; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D005348:Fibrocystic Breast Disease / Q000235:genetics* / Q000473:pathology; D015870:Gene Expression; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008800:Mexico; D008875:Middle Aged; D060787:Neoplasm Grading; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B