title: [Food sensitization in children with Opisthorchis felineus invasion].
abstract: OBJECTIVE
  To determine the mechanism of food sensitization in children with chronic Opisthorchis felineus invasion.
  
  
  METHODS
  During the epidemiological study the groups of patients (7-10 years) with chronic opisthorchiasis (n = 237) and children without chronic opisthorchiasis (n = 496) were formed. The investigation included interviewing of parents/guardians, measurement of total IgE, specific IgE to food allergens and component-resolved diagnostic, real-time PCR in stool samples.
  
  
  RESULTS
  The chronic opisthorchiasis invasion in children is associated with reduced risk of food sensitization, compared with non-infected group (9.7 vs 16.94%, OR = 0.53; 95% CI 0.31-0.88; p = 0.01). Opisthorchiasis of high intensity negatively correlated with increased level of specific IgE to food allergens in serum (OR = 0.46; 95% CI 0.24-0.91; p = 0.023). The association between level of total IgE and intensity of opisthorchiasis combinated with food sensitization was found. The sensitization to allergens class I (cyp c1, cor a11, gal d2, pru p3) is more prevalent in patients with opisthorchiasis, in uninfected children the sensitization to bet v1-homologues (mal d1, pru p1, cor a1, ara h8) is most common.
  
  
  CONCLUSIONS
  The epidemiological data on the effect of the Opisthorchis felineus invasion on mechanisms of food sensitization in children were obtained.
authors: L M
authors: LM
authors: Ogorodoava
authors: O S
authors: OS
authors: Fedorova
authors: M M
authors: MM
authors: Fedotova
authors: T A
authors: TA
authors: Evdokimova
mesh_terms: D000485:Allergens / Q000276:immunology; D000818:Animals; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005512:Food Hypersensitivity / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology* / Q000469:parasitology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D009889:Opisthorchiasis / Q000453:epidemiology / Q000276:immunology* / Q000469:parasitology*; D009891:Opisthorchis / Q000472:pathogenicity*; D021183:Peanut Hypersensitivity / Q000175:diagnosis / Q000276:immunology; D060888:Real-Time Polymerase Chain Reaction
chemical_list: D000485:Allergens; D007073:Immunoglobulin E