title: β-Agarofurans and Sesquiterpene Pyridine Alkaloids from Maytenus spinosa.
abstract: Nine new β-dihydroagarofurans (1-9) and four new sesquiterpene pyridine alkaloids (10-13) were isolated from the leaves of Maytenus spinosa. Their structures were determined mainly by 1D- and 2D-NMR spectroscopic studies. The absolute configuration of compound 6 was established using CD spectroscopy. Several derivatives (14-20) were prepared from the sesquiterpene 13. Most of the sesquiterpenoids were tested for anti-HIV activity, but only compound 1 was found to be active.
authors: Instituto Universitario de Bio-Orgánica Antonio González (CIBICAN), Departamento de Química Orgánica, Universidad de La Laguna , La Laguna 38206, Tenerife, Spain.|Facultad de Ciencias Químicas, Universidad Nacional de Córdoba , Córdoba X5000HUA, Argentina.
authors: Fátima
authors: F
authors: Gutiérrez-Nicolás
authors: Facultad de Ciencias Químicas, Universidad Nacional de Córdoba , Córdoba X5000HUA, Argentina.|Instituto Multidisciplinar de Biología Vegetal (IMBIV; CONICET-UNC ), Casilla de Correo 495, Córdoba X5000HUA, Argentina.
authors: Juan C
authors: JC
authors: Oberti
authors: Instituto Universitario de Bio-Orgánica Antonio González (CIBICAN), Departamento de Química Orgánica, Universidad de La Laguna , La Laguna 38206, Tenerife, Spain.
authors: Ángel G
authors: ÁG
authors: Ravelo
authors: Instituto Universitario de Bio-Orgánica Antonio González (CIBICAN), Departamento de Química Orgánica, Universidad de La Laguna , La Laguna 38206, Tenerife, Spain.
authors: Ana
authors: A
authors: Estévez-Braun
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001118:Argentina; D029755:Maytenus / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D019380:Anti-HIV Agents; D011725:Pyridines; D012717:Sesquiterpenes