title: Seizure termination.
abstract: A better understanding of the mechanisms by which most focal epileptic seizures stop spontaneously within a few minutes would be of highest importance, because they could potentially help to improve existing and develop novel therapeutic measures for seizure control. Studies devoted to unraveling mechanisms of seizure termination often take one of the two following approaches. The first approach focuses on metabolic mechanisms such as ionic concentrations, acidity, or neuromodulator release, studying how they are dependent on, and in turn affect changes of neuronal activity. The second approach uses quantitative tools to derive functional networks from electrophysiological recordings and analyzes these networks with mathematical methods, without focusing on actual details of cell biology. In this chapter, we summarize key results obtained by both of these approaches and attempt to show that they are complementary and equally necessary in our aim to gain a better understanding of seizure termination.
authors: Department of Neurology, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.
authors: Frédéric
authors: F
authors: Zubler
authors: Department of Neurology, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.
authors: Andreas
authors: A
authors: Steimer
authors: Department of Neurology, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.
authors: Heidemarie
authors: H
authors: Gast
authors: Department of Neurology, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland. Electronic address: kaspar.schindler@insel.ch.
authors: Kaspar A
authors: KA
authors: Schindler
mesh_terms: D000818:Animals; D001921:Brain / Q000503:physiopathology*; D004569:Electroencephalography; D004827:Epilepsy / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D009415:Nerve Net / Q000473:pathology / Q000503:physiopathology*; D018377:Neurotransmitter Agents / Q000378:metabolism
chemical_list: D018377:Neurotransmitter Agents
keywords: Complex systems; EEG; Functional networks; Graph theory; Molecular mechanisms