title: [Silver(I)(pyridine-containing ligand)] complexes as unusual catalysts for A(3)-coupling reactions.
abstract: Two original macrocyclic silver(I)(pyridine-containing ligand) complexes [Ag(I)(Pc-L)] were synthesized and characterized. Their ability to catalyze the coupling among aldehydes, terminal alkynes and amines (A(3)-coupling) was demonstrated. The reaction could be performed under conventional as well as dielectric heating. The catalysts were effective in both cases, but dielectric heating allowed a lower catalyst loading and reduced ratio among reaction partners in shorter reaction times. The reaction scope was broad, including aryl/alkyl aldehydes, aryl/alkyl acetylenes and secondary aliphatic amines. Some unprecedented propargylamines have been prepared. The new catalytic system was also tested with more challenging coupling partners such as aniline and ketones.
authors: Dipartimento di Scienze Farmaceutiche, Sezione di Chimica Generale e Organica "A. Marchesini", Università degli Studi di Milano , Via Venezian 21, 20133 Milano, Italy.
authors: Michael
authors: M
authors: Trose
authors: Monica
authors: M
authors: Dell'Acqua
authors: Tommaso
authors: T
authors: Pedrazzini
authors: Valentina
authors: V
authors: Pirovano
authors: Emma
authors: E
authors: Gallo
authors: Elisabetta
authors: E
authors: Rossi
authors: Alessandro
authors: A
authors: Caselli
authors: Giorgio
authors: G
authors: Abbiati
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D000814:Aniline Compounds / Q000737:chemistry; D002384:Catalysis; D007659:Ketones / Q000737:chemistry; D008024:Ligands; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D010293:Pargyline / Q000031:analogs & derivatives / Q000737:chemistry; D011437:Propylamines / Q000737:chemistry; D012834:Silver / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000480:Alkynes; D000588:Amines; D000814:Aniline Compounds; D007659:Ketones; D008024:Ligands; D009942:Organometallic Compounds; D011437:Propylamines; C009054:propargylamine; D012834:Silver; D010293:Pargyline; C023650:aniline