title: Development of a novel aluminum-free glass ionomer cement based on magnesium/strontium-silicate glasses.
abstract: The effects of strontium substitution for magnesium in a novel aluminum-free multicomponent glass composition for glass ionomer cements (GICs) were investigated. A series of glass compositions were prepared based on SiO2-P2O5-CaO-ZnO-MgO(1-X)-SrOX-CaF2 (X=0, 0.25, 0.5 and 0.75). The mechanical properties of GICs prepared were characterized by compressive strength, flexural strength, flexural modules, and microhardness. Cell proliferation was evaluated indirectly by CCK-8 assay using various dilutions of the cement and rat mesenchyme stem cells. Incorporation of strontium instead of magnesium in the glasses has a significant influence on setting time of the cements and the properties. All mechanical properties of the GICs with SrO substitution at X=0.25 were significantly increased, then gradually decreased with further increase of the amount of strontium substitution in the glass. The GIC at X=0.25, also, showed an improved cell viability at low doses of the cement extracts in comparison with other groups or control without extracts. The results of this study demonstrate that the glass compositions with strontium substitution at low levels can be successfully used to prepare aluminum-free glass ionomer cements for repair and regeneration of hard tissues.
authors: Department of Biomaterials Science, College of Dentistry, Dankook University, Cheonan 330-714, Republic of Korea; Department of Nanobiomedical Science & BK21 Plus NBM Global Research Center for Regenerative Medicine, Dankook University Graduate School, Cheonan 330-714, Republic of Korea.
authors: Dong-Ae
authors: DA
authors: Kim
authors: Glass Research Department, National Research Centre, Dokki, Cairo, Egypt.
authors: Hany A
authors: HA
authors: Abo-Mosallam
authors: Department of Nanobiomedical Science & BK21 Plus NBM Global Research Center for Regenerative Medicine, Dankook University Graduate School, Cheonan 330-714, Republic of Korea; Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 330-714, Republic of Korea.
authors: Hye-Young
authors: HY
authors: Lee
authors: Department of Biomaterials Science, College of Dentistry, Dankook University, Cheonan 330-714, Republic of Korea; Department of Nanobiomedical Science & BK21 Plus NBM Global Research Center for Regenerative Medicine, Dankook University Graduate School, Cheonan 330-714, Republic of Korea.
authors: Gyu-Ri
authors: GR
authors: Kim
authors: Department of Biomaterials Science, College of Dentistry, Dankook University, Cheonan 330-714, Republic of Korea; Department of Nanobiomedical Science & BK21 Plus NBM Global Research Center for Regenerative Medicine, Dankook University Graduate School, Cheonan 330-714, Republic of Korea; Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 330-714, Republic of Korea.
authors: Hae-Won
authors: HW
authors: Kim
authors: Department of Biomaterials Science, College of Dentistry, Dankook University, Cheonan 330-714, Republic of Korea; Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 330-714, Republic of Korea. Electronic address: haelee@dku.edu.
authors: Hae-Hyoung
authors: HH
authors: Lee
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D005899:Glass Ionomer Cements / Q000737:chemistry* / Q000494:pharmacology; D008274:Magnesium / Q000737:chemistry* / Q000494:pharmacology; D008297:Male; D059630:Mesenchymal Stem Cells; D051381:Rats; D017640:Silicates / Q000737:chemistry* / Q000494:pharmacology; D013324:Strontium / Q000737:chemistry* / Q000494:pharmacology; D013499:Surface Properties
chemical_list: D005899:Glass Ionomer Cements; D017640:Silicates; D008274:Magnesium; D013324:Strontium
keywords: Aluminum-free; Bone cement; Cell viability; Glass ionomer cement; Mechanical properties; Strontium