title: Successful treatment of severe thrombocytopenia with the use of thrombopoeitin receptor agonist eltrombopag in a patient with chronic myelomonocytic leukemia.
abstract: Chronic myelomonocytic leukemia (CMML) is a clonal disorder of hematopoietic stem cells often occurring in elderly patients. The combination of CMML with autoimmune manifestations, including immune-mediated thrombocytopenia, has been described before in a number of case reports. To our knowledge, this is the first reported case of the successful treatment of CMML-related thrombocytopenia with a thrombopoeitin receptor agonist, eltrombopag.
authors: Department of Hematology/Oncology, St Joseph's Regional Medical Center, Seton Hall University School of Health and Medical Sciences, Paterson, NJ, USA.
authors: Yashpal
authors: Y
authors: Modi
authors: Department of Hematology/Oncology, St Joseph's Regional Medical Center, Seton Hall University School of Health and Medical Sciences, Paterson, NJ, USA hamidshaaban@gmail.com.
authors: Hamid
authors: H
authors: Shaaban
authors: Department of Hematology/Oncology, St Joseph's Regional Medical Center, Seton Hall University School of Health and Medical Sciences, Paterson, NJ, USA.
authors: Dron
authors: D
authors: Gauchan
authors: Department of Hematology/Oncology, St Joseph's Regional Medical Center, Seton Hall University School of Health and Medical Sciences, Paterson, NJ, USA.
authors: Michael
authors: M
authors: Maroules
mesh_terms: D001565:Benzoates / Q000627:therapeutic use*; D006801:Humans; D006834:Hydrazines / Q000627:therapeutic use*; D015477:Leukemia, Myelomonocytic, Chronic / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011720:Pyrazoles / Q000627:therapeutic use*; D053628:Receptors, Thrombopoietin / Q000819:agonists*; D013921:Thrombocytopenia / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D001565:Benzoates; D006834:Hydrazines; D011720:Pyrazoles; D053628:Receptors, Thrombopoietin; C520809:eltrombopag
keywords: Eltrombopag; chronic myelomonocytic; immune; leukemia; thrombocytopenia