title: Plasma insulin, C-peptide and blood glucose and the risk of gastric cancer: the Japan Public Health Center-based prospective study.
abstract: To date, the association between diabetes mellitus (DM) and gastric cancer has been controversial, including the underlying mechanism. We investigated the association between plasma diabetic biomarkers (insulin, C-peptide, and blood glucose) and gastric cancer risk. In addition, homeostasis model assessment of insulin resistance (HOMA-IR) and homeostasis model assessment of β-cell function (HOMA-β) were calculated. A total of 36,745 subjects aged 40-69 years in the Japan Public Health Center-based prospective study (JPHC) who returned the baseline questionnaire and provided blood samples were followed from 1990 to 2004. In the present analysis, 477 cases and 477 matched controls were used. The odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) for developing gastric cancer were calculated using conditional logistic regression models. Plasma insulin was positively associated with increased risk of gastric cancer; compared to tertile 1, ORs were 1.69 (95% CI = 1.11-2.59) and 2.01 (1.19-3.38) for tertiles 2 and 3, respectively (p for trend = 0.009). In men, C-peptide was also positively associated with a significant risk; corresponding ORs were 1.42 (0.85-2.38) and 1.91 (1.03-3.54), respectively (p for trend = 0.04). These findings were confirmed for blood samples from the fasting group (≥8 hr after a meal). Higher HOMA-IR was also associated with increased risk, whereas no association was observed for blood glucose. Our findings suggest that Japanese population with higher insulin and C-peptide levels derived from insulin resistance have an elevated risk of gastric cancer.
authors: Epidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
authors: Akihisa
authors: A
authors: Hidaka
authors: Shizuka
authors: S
authors: Sasazuki
authors: Atsushi
authors: A
authors: Goto
authors: Norie
authors: N
authors: Sawada
authors: Taichi
authors: T
authors: Shimazu
authors: Taiki
authors: T
authors: Yamaji
authors: Motoki
authors: M
authors: Iwasaki
authors: Manami
authors: M
authors: Inoue
authors: Mitsuhiko
authors: M
authors: Noda
authors: Hisao
authors: H
authors: Tajiri
authors: Shoichiro
authors: S
authors: Tsugane
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects; D001786:Blood Glucose / Q000032:analysis*; D002096:C-Peptide / Q000097:blood*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011634:Public Health; D012306:Risk; D013274:Stomach Neoplasms / Q000097:blood / Q000209:etiology*
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin
keywords: gastric cancer risk; plasma C-peptide; plasma blood glucose; plasma insulin; prospective study