title: miR-342-3p suppresses proliferation, migration and invasion by targeting FOXM1 in human cervical cancer.
abstract: FOXM1 is a well-established oncogenic factor that has been reported to be involved in multiple biological processes including cell proliferation, growth, angiogenesis, migration and invasion. It can also be regulated by miRNAs. In this study, we reported that FOXM1 is directly targeted by miR-342-3p, which is down-regulated along with its host gene, EVL, in human cervical cancer tissues compared to the adjacent normal tissues. Functional studies suggested that the overexpression of miR-342-3p inhibits cell proliferation, migration and invasion in cervical cell lines. FOXM1 is upregulated and negatively correlates with miR-342-3p in cervical cancer tissues, and the overexpression of FOXM1 rescues the phenotype changes induced by the overexpression of miR-342-3p.
authors: Department of Obstetrics and Gynecology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China; Department of Gynecology and Obstetrics, The Affiliated Hiser Medical Group of Qingdao University Medical College, Qingdao, China.
authors: Xu-Ri
authors: XR
authors: Li
authors: Department of Obstetrics and Gynecology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.
authors: Hui-Jun
authors: HJ
authors: Chu
authors: Department of Obstetrics and Gynecology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.
authors: Teng
authors: T
authors: Lv
authors: Department of Obstetrics and Gynecology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.
authors: Lei
authors: L
authors: Wang
authors: Department of Obstetrics and Gynecology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China; Department of Gynecology and Obstetrics, The Affiliated Hiser Medical Group of Qingdao University Medical College, Qingdao, China.
authors: Shou-Fang
authors: SF
authors: Kong
authors: Department of Obstetrics and Gynecology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China; Gynecological Tumors and Reproductive Function Protection Laboratory of Qingdao, China; Key Laboratory of Cervical Disease of Qingdao, China. Electronic address: daishuzhen2001@163.com.
authors: Shu-Zhen
authors: SZ
authors: Dai
mesh_terms: D000328:Adult; D001483:Base Sequence; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics*; D049109:Cell Proliferation; D015536:Down-Regulation / Q000235:genetics; D005260:Female; D000072278:Forkhead Box Protein M1; D051858:Forkhead Transcription Factors / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism*; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000235:genetics; D010641:Phenotype; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000473:pathology*
chemical_list: C107585:FOXM1 protein, human; D000072278:Forkhead Box Protein M1; D051858:Forkhead Transcription Factors; C546176:MIRN342 microRNA, human; D035683:MicroRNAs
keywords: Cervical cancer; EVL; Forkhead Box M1; miR-342-3p