title: Development of a pilot project on data sharing among partners of the Italian Hub of Population Biobanks (HIBP): association between lipid profile and socio-demographic variables.
abstract: The Italian Hub of Population Biobanks (HIBP) includes both ongoing and completed studies that are heterogeneous in both their purpose and in the specimens collected. The heterogeneity in starting conditions makes sharing study data very difficult because of technical, ethical, and collection rights issues that hamper collaboration and synergy. With the aim of overcoming these difficulties and establishing the "proof-of-concept" that sharing studies is achievable among Italian collections, a data-sharing pilot project has been agreed to by HIBP members. Participants agreed to the general methodology and signed a shared Data Transfer Agreement. The biobanks involved were: EURAC (Micros study), CIG (GEHA project), CNESPS (FINE, MATISS, MONICA, OEC1998, ITR (Italian Twin Register), and IPREA studies, and MOLIBANK (Moli-Sani project). Biobank data were uploaded into a common database using a dedicated informatics infrastructure. Demographic data, and anthropometric and hematochemical parameters were shared for each record. Each biobank uploaded into the common database a dataset with a minimum of 1000 subjects, for a total of 5071 records. After a harmonization process, the final dataset included 3882 records. Subjects were grouped into three main geographic areas of Italy (North, Center, and South) and separate analyses were performed for men and women. The 3882 records were analyzed through multivariate logistic regression analysis. Results were expressed as odds ratios with 95% confidence interval. Results show several geographical differences in the lipidemic pattern, mostly regarding cholesterol-HDL, which represents a strong basis for further, deeper sample-based studies. This HIBP pilot study aimed to prove the feasibility of such collaborations and it provides a methodological prototype for future studies based on the participation in the partnership of well-established quality collections.
authors: 1 Department of Haematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità , Rome, Italy .
authors: Mariarosaria
authors: M
authors: Napolitano
authors: Filippo
authors: F
authors: Santoro
authors: Maria
authors: M
authors: Puopolo
authors: Chiara
authors: C
authors: Donfancesco
authors: Lucia
authors: L
authors: Galluzzo
authors: Alessandro
authors: A
authors: De Grandi
authors: Elisa
authors: E
authors: Cevenini
authors: Amalia
authors: A
authors: De Curtis
authors: Federica
authors: F
authors: Sevini
authors: Luigi
authors: L
authors: Palmieri
authors: Deborah
authors: D
authors: Mascalzon
authors: Paolo
authors: P
authors: Roazzi
authors: Emanuele
authors: E
authors: Scafato
authors: Peter
authors: P
authors: Pramstaller
authors: Licia
authors: L
authors: Iacoviello
authors: Maria B
authors: MB
authors: Donati
authors: Simona
authors: S
authors: Giampaoli
authors: Claudio
authors: C
authors: Franceschi
authors: Filippo
authors: F
authors: Belardelli
authors: Elena
authors: E
authors: Bravo
mesh_terms: D000293:Adolescent; D000328:Adult; D018070:Biological Specimen Banks; D002648:Child; D002675:Child, Preschool; D003299:Cooperative Behavior; D003710:Demography; D005260:Female; D006801:Humans; D033181:Information Dissemination; D007558:Italy; D008055:Lipids / Q000097:blood*; D008297:Male; D016017:Odds Ratio; D010865:Pilot Projects; D055815:Young Adult
chemical_list: D008055:Lipids