title: The Au clusters induce tumor cell apoptosis via specifically targeting thioredoxin reductase 1 (TrxR1) and suppressing its activity.
abstract: Au25 clusters stabilized by tridecapeptides were firstly synthesized, which can well penetrate the cell membrane and exactly locate in the cytoplasm. Hence the Au clusters significantly suppress the TrxR1 activity in the cytoplasm, and further induce the up-regulation of the activated PARP level which allows the tumor cell apoptosis to occur in a Au dose dependent manner.
authors: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. China. gaoxy@ihep.ac.cn.
authors: Ru
authors: R
authors: Liu
authors: Yaling
authors: Y
authors: Wang
authors: Qing
authors: Q
authors: Yuan
authors: Deyi
authors: D
authors: An
authors: Jingyuan
authors: J
authors: Li
authors: Xueyun
authors: X
authors: Gao
mesh_terms: D000595:Amino Acid Sequence; D017209:Apoptosis / Q000187:drug effects*; D004789:Enzyme Activation / Q000187:drug effects; D006046:Gold / Q000737:chemistry* / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry / Q000378:metabolism* / Q000627:therapeutic use; D009842:Oligopeptides / Q000737:chemistry; D010316:Particle Size; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D017382:Reactive Oxygen Species / Q000378:metabolism; D054481:Thioredoxin Reductase 1 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015854:Up-Regulation
chemical_list: D009842:Oligopeptides; D017382:Reactive Oxygen Species; D006046:Gold; D054481:Thioredoxin Reductase 1; D011065:Poly(ADP-ribose) Polymerases