title: Interaction between Helicobacter pylori infection, nonsteroidal anti-inflammatory drugs and/or low-dose aspirin use: old question new insights.
abstract: Previous reports clearly demonstrated that Helicobacter pylori (H. pylori) infection, nonsteroidal anti-inflammatory drugs (NSAID) or low dose aspirin (ASA) use significantly and independently increased the risk for the development of peptic ulcer disease. Today, the presence of H. pylori infection associated with low dose ASA and/or NSAID use in the same patient is becoming more frequent and therefore the potential interaction between these factors and the consequences of it has important implications. Whether NSAID intake in the presence of H. pylori infection may further increase the risk of peptic ulcer carried by the presence of only one risk factor is still a matter of debate. Studies on the interaction between the two risk factors yielded conflicting data and no consensus has been reached in the last years. In addition, the interaction between H. pylori infection and low-dose ASA remains even more controversial. In real clinical practice, we can find different clinical scenarios involving these three factors associated with the presence of different gastrointestinal and cardiovascular risk factors. These huge variety of possible combinations greatly hinder the decision making process of physicians.
authors: Carlos Sostres, Carla Jerusalen Gargallo, Angel Lanas, Service Department of Digestive Diseases, University Hospital Lozano Blesa, 50009 Zaragoza, Spain.
authors: Carlos
authors: C
authors: Sostres
authors: Carlos Sostres, Carla Jerusalen Gargallo, Angel Lanas, Service Department of Digestive Diseases, University Hospital Lozano Blesa, 50009 Zaragoza, Spain.
authors: Carla Jerusalen
authors: CJ
authors: Gargallo
authors: Carlos Sostres, Carla Jerusalen Gargallo, Angel Lanas, Service Department of Digestive Diseases, University Hospital Lozano Blesa, 50009 Zaragoza, Spain.
authors: Angel
authors: A
authors: Lanas
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D002318:Cardiovascular Diseases / Q000139:chemically induced* / Q000382:microbiology* / Q000401:mortality; D016481:Helicobacter Infections / Q000150:complications* / Q000382:microbiology / Q000401:mortality; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D010437:Peptic Ulcer / Q000139:chemically induced* / Q000382:microbiology* / Q000401:mortality; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin
keywords: Helicobacter pylori eradication; Helicobacter pylori infection; Low dose aspirin; Nonsteroidal anti-inflammatory drugs; Peptic ulcer disease