title: [Malignant mesothelioma risk factors: experience in the General Hospital of Mexico].
abstract: BACKGROUND
  Malignant mesothelioma is a neoplasm of bad prognosis, it is linked with asbestos contact, but there are cases without this antecedent.
  
  
  OBJECTIVE
  To investigate the relationship of asbestos exposition and other factors with malignant mesothelioma.
  
  
  METHODS
  Retrospective analysis of histologic confirmed cases of malignant mesothelioma, neoplasic familiar history, tobacco smoking, exposure to wood smoke and to asbestos, were annotated in a paired case/control study 1: 1-3 with logistic regression model to identify risk factors for OR.
  
  
  RESULTS
  61 cases of malignant mesothelioma were confirmed by histopathologic study, 41 male and 20 female. Mean age was 56 years ± 13 years; 56 cases (91.8%) correspond to epithelial malignant mesothelioma, three sarcomatous (4.9%) one desmoplastic and one biphasic. One in eight (13.1%) had exposure to asbestos. Model of logistic regression with four variables: history of familiar cancer, tobacco smoking, wood smoke and asbestos exposition, the the last one with an OR= 3.083 and p > 0.05. No other variables found to be a risk factor for malignant mesothelioma.
  
  
  CONCLUSIONS
  Exposure to asbestos is a risk factor for malignant mesothelioma, which is confirmed in this study, however it is important to extend the investigation of other possible causal factors of this disease.
authors: Servicio de Neumología y Cirugía de Tórax, Hospital General de México O.D. Secretaría de Salud, Mexico. drhernandezsolis@yahoo.com.mx;
authors: Alejandro
authors: A
authors: Hernández-Solís
authors: Servicio de Neumología y Cirugía de Tórax. Hospital General de México O.D. Secretaría de Salud, Mexico. cyntiagarciah@hotmail.com.
authors: Cyntia
authors: C
authors: Garcia-Hernández
authors: Facultad de Medicina, Universidad Nacional Autónoma de México.
authors: Arturo
authors: A
authors: Reding-Bernal
authors: Servicio de Patología. Hospital General de México O.D. Secretaría de Salud.
authors: Humberto
authors: H
authors: Cruz-Ortiz
authors: Facultad de Medicina, Universidad Nacional Autónoma de México.
authors: Raúl
authors: R
authors: Cicero-Sabido
mesh_terms: D000328:Adult; D000368:Aged; D001194:Asbestos / Q000009:adverse effects; D004781:Environmental Exposure; D005260:Female; D006769:Hospitals, General / Q000706:statistics & numerical data; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D008297:Male; D008654:Mesothelioma / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D000086002:Mesothelioma, Malignant; D008875:Middle Aged; D009386:Neoplastic Syndromes, Hereditary / Q000453:epidemiology; D009784:Occupational Diseases / Q000209:etiology / Q000473:pathology; D010997:Pleural Neoplasms / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D012189:Retrospective Studies; D012307:Risk Factors; D012424:Rural Population / Q000706:statistics & numerical data; D012906:Smoke / Q000009:adverse effects; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology; D014057:Tomography, X-Ray Computed; D014505:Urban Population / Q000706:statistics & numerical data; D014934:Wood; D014026:Nicotiana
chemical_list: D012906:Smoke; D001194:Asbestos
keywords: Malignant mesothelioma; asbestos; humo de leña; mesotelioma maligno; wood smoke exposure