title: Synthesis, enzymatic resolution, and stereochemical characterization of isoparaconic acid derivatives: a combined experimental and theoretical investigation.
abstract: Enantiomerically enriched isoparaconic acid derivatives were obtained by kinetic enzymatic resolution. To explain the solvent dependence observed for their optical rotatory power a computational investigation of their chiroptical properties was performed.
authors: Dipartimento di Scienze Chimiche e Farmaceutiche, Università degli Studi di Trieste, Trieste, Italy.
authors: Fulvia
authors: F
authors: Felluga
authors: Cristina
authors: C
authors: Forzato
authors: Giuseppe
authors: G
authors: Mazzeo
authors: Patrizia
authors: P
authors: Nitti
authors: Giuliana
authors: G
authors: Pitacco
authors: Stefano
authors: S
authors: Superchi
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D000818:Animals; D060326:Chemistry Techniques, Synthetic; D006867:Hydrolases / Q000378:metabolism*; D007700:Kinetics; D011789:Quantum Theory; D013237:Stereoisomerism
chemical_list: C571316:paraconic acid; D006867:Hydrolases; D015107:4-Butyrolactone
keywords: chiroptical properties; isoparaconic acid derivatives; kinetic enzymatic resolution