title: Distinct breast cancer subtypes in women with early-onset disease across races.
abstract: BACKGROUND
  Racial disparities among breast cancer (BCa) patients are known but not well studied in early-onset BCa. We analyzed molecular subtypes in early-onset BCa across five major races.
  
  
  METHODS
  A total of 2120 cases were included from non-Hispanic White (NHW), African American (AA) and Hispanic, Chinese and Indian. Based on ER, PR and HER-2 status, BCa was classified into 4 intrinsic subtypes as Luminal A, Luminal B, HER2/neu overexpression and Triple negative BCa (TNBC) subtypes. Data was stratified according to race and age as younger/early-onset group (40-years and younger) and older group (50-years and older).
  
  
  RESULTS
  In early-onset BCa, incidence of TNBC was significantly higher (p = 0.0369) in Indian women followed by AA, Hispanic, NHW and Chinese women. Incidence of Her2 over-expression subtype also was highest in Indian women, followed by Hispanic, Chinese, AA and NHW women. In contrast, Luminal B subtype was most significantly higher in AA women (p = 0.0000) followed by NHW (p = 0.0002), Chinese (p = 0.0003), Hispanic (0.0128) and Indian (p = 0.0468) women. Luminal A subtype was most significantly reduced in Indian women (p = 0.0113) followed by Hispanic, AA, NHW and Chinese women. These results were based on statistical analysis with the mean of older group populations.
  
  
  CONCLUSIONS
  These results show significant disparities in receptor subtypes across races. This study will contribute in developing optimal clinical trial protocols and personalized management strategies for early-onset BCa patients.
authors: Department of Pathology, New York Harbor Healthcare System, New York University School of Medicine New York, NY, USA ; Rajiv Gandhi Cancer Institute & Research Centre Delhi, India.
authors: Mandeep
authors: M
authors: Singh
authors: Department of Pathology, New York Harbor Healthcare System, New York University School of Medicine New York, NY, USA.
authors: Yi
authors: Y
authors: Ding
authors: Department of Pathology, Memorial Sloan Kettering Cancer Center New York, NY, USA.
authors: Li-Ying
authors: LY
authors: Zhang
authors: Department of Breast Surgery, The First Hospital of Jilin University China.
authors: Dong
authors: D
authors: Song
authors: Department of Pathology, UT MD Anderson Cancer Center Houston, TX, USA.
authors: Yun
authors: Y
authors: Gong
authors: NYU Cancer Institute New York, NY, USA.
authors: Sylvia
authors: S
authors: Adams
authors: Department of Pathology, Memorial Sloan Kettering Cancer Center New York, NY, USA.
authors: Dara S
authors: DS
authors: Ross
authors: NYU Cancer Institute New York, NY, USA.
authors: Jin-Hua
authors: JH
authors: Wang
authors: Rajiv Gandhi Cancer Institute & Research Centre Delhi, India.
authors: Shruti
authors: S
authors: Grover
authors: Rajiv Gandhi Cancer Institute & Research Centre Delhi, India.
authors: Dinesh Chandra
authors: DC
authors: Doval
authors: State University of New York-Downstate Medical Center Brooklyn, NY, USA.
authors: Charles
authors: C
authors: Shao
authors: Association of Chinese American Physicians Flushing, NY, USA.
authors: Zi-Li
authors: ZL
authors: He
authors: Chinese American Medical Society New York, NY, USA.
authors: Victor
authors: V
authors: Chang
authors: Chinese American Medical Society New York, NY, USA.
authors: Warren W
authors: WW
authors: Chin
authors: Department of Pathology, New York Harbor Healthcare System, New York University School of Medicine New York, NY, USA.
authors: Fang-Ming
authors: FM
authors: Deng
authors: Department of Pathology, New York Harbor Healthcare System, New York University School of Medicine New York, NY, USA.
authors: Baljit
authors: B
authors: Singh
authors: Association of Chinese American Physicians Flushing, NY, USA ; Department of Pathology, Mount Sinai School of Medicine New York, NY, USA.
authors: David
authors: D
authors: Zhang
authors: Department of Pathology, New York Harbor Healthcare System, New York University School of Medicine New York, NY, USA ; Association of Chinese American Physicians Flushing, NY, USA.
authors: Ru-Liang
authors: RL
authors: Xu
authors: Department of Pathology, New York Harbor Healthcare System, New York University School of Medicine New York, NY, USA ; NYU Cancer Institute New York, NY, USA ; Association of Chinese American Physicians Flushing, NY, USA.
authors: Peng
authors: P
authors: Lee
keywords: Breast cancer subtypes; global; races; receptor; risk