title: Reinforcing effect of calcium sulfate cement bovine bone morphogenetic protein on vertebral in the rabbit model of osteoporosis.
abstract: OBJECTIVE
  To observe reinforcing effect of calcium sulfate cement (CSC) bovine bone morphogenetic protein (bBMP) on vertebral in the rabbit model of osteoporosis.
  
  
  METHODS
  A total of 48 New Zealand white rabbits were randomly divided into group I (blank control group), group II (CSC injection group), group III (CSC/bBMP injection group) and control group. White rabbit osteoporosis model was established rapidly by using castration method+methylprednisolone candidate. After modeling, groups II, III were given corresponding vertebral body injection material, and 4 animals were sacrificed respectively at 24 h, 6 weeks, 12 weeks after vertebral plasty. Tissue pathological status, vertebral mineral density and vertebral body bone mechanical strength were observed.
  
  
  RESULTS
  Vertebral body structure form was normal in the groups II and III. Trabecular bone coarsens, connection and repair were observed in micro fracture and bone defects, bone trabecular connectivity was superior to group I significantly; vertebral body compression strength in the group I was on the decline, vertebral compression strength in the groups II and III was on the rise, the largest vertebra. Postoperative BMC and BMD in groups II and III were increased, and significantly higher than group I after 6 weeks (P<0.05), BMC and BMD in group III after 12 weeks were higher than the other three groups.
  
  
  CONCLUSIONS
  Compound bBMP CSC has good bone induction. It can improve the three-dimensional construction effect for osteoporosis vertebral trabecula, and can significantly improve the vertebral strength, as a vertebral packing material with good application prospect.
authors: Xinjiang Autonomous Region People's Hospital, Urumqi, Xinjiang 830001, China.
authors: Jie
authors: J
authors: Zhang
authors: Anatomy Section, Xinjiang Medical University, Urumqi, Xinjiang 830001, China. Electronic address: zhangjtg@163.com.
authors: Sheng-Guo
authors: SG
authors: Chen
authors: Xinjiang Autonomous Region People's Hospital, Urumqi, Xinjiang 830001, China.
authors: Kaken
authors: K
authors: Habaerxi
authors: Xinjiang Autonomous Region People's Hospital, Urumqi, Xinjiang 830001, China.
authors: Shawuti
authors: S
authors: Alimujiang
authors: Otolaryngology, Xinjiang Medical University, Urumqi, Xinjiang 830001, China.
authors: Yu
authors: Y
authors: Chen
authors: Xinjiang Autonomous Region People's Hospital, Urumqi, Xinjiang 830001, China.
authors: Ming-Zhen
authors: MZ
authors: Peng
authors: Xinjiang Autonomous Region People's Hospital, Urumqi, Xinjiang 830001, China.
authors: Rong
authors: R
authors: Yue
authors: Xinjiang Autonomous Region People's Hospital, Urumqi, Xinjiang 830001, China.
authors: Yu-Lian
authors: YL
authors: Wu
authors: Xinjiang Autonomous Region People's Hospital, Urumqi, Xinjiang 830001, China.
authors: De-Quan
authors: DQ
authors: Wang
authors: Xinjiang Autonomous Region People's Hospital, Urumqi, Xinjiang 830001, China.
authors: Yu-Ming
authors: YM
authors: Chen
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D001843:Bone Cements / Q000737:chemistry / Q000494:pharmacology*; D015519:Bone Density / Q000187:drug effects; D019485:Bone Morphogenetic Proteins / Q000737:chemistry / Q000494:pharmacology*; D002133:Calcium Sulfate / Q000737:chemistry / Q000494:pharmacology*; D002417:Cattle; D005260:Female; D010024:Osteoporosis / Q000503:physiopathology*; D011817:Rabbits; D033081:Shear Strength; D013131:Spine / Q000187:drug effects* / Q000502:physiology
chemical_list: D001843:Bone Cements; D019485:Bone Morphogenetic Proteins; D002133:Calcium Sulfate
keywords: BBMP; CSC; Osteoporosis; Rabbit; Vertebral reinforcing