title: Cognitive function in Hashimoto's thyroiditis under levothyroxine treatment.
abstract: ΟBJECTIVE: Although overt hypothyroidism has been documented as exerting detrimental effects on cognition and behavior, it remains controversial whether subclinical hypothyroidism or euthyroid patients with Hashimoto's thyroiditis (HT) under levothyroxine (LT4) treatment may experience any noticeable decline in cognitive function.
  
  
  METHODS
  Two otherwise healthy, highly-functioning, first-degree relatives with a diagnosis of HT, under LT4 treatment for two years, were prospectively recruited into a clinical research study setting and followed for a year.
  
  
  METHODS
  Thyroid functions tests and a detailed battery of tests assessing global cognitive status, attention, verbal and working memory, visuoperceptual skills, executive functions and mood were performed at baseline and at one year after recruitment.
  
  
  RESULTS
  Overall, patients' performance on the neuropsychological battery was good and, in the majority of cognitive functions, their performance could be characterized as exceptional. No noticeable changes in any of the studied parameters were detected.
  
  
  CONCLUSIONS
  The present case study failed to detect any noticeable changes in the cognitive and emotional function of two women with HT under LT4 treatment. The course of cognitive function of the two HT patients, evaluated by a detailed battery of tests, tends to confirm the benign nature of HT.
authors: Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors: Vaitsa
authors: V
authors: Giannouli
authors: Department of Endocrinology, 424 General Army Hospital, Thessaloniki, Greece.
authors: Konstantinos A
authors: KA
authors: Toulis
authors: AHEPA Hospital, Aristotle University of Thessaloniki; Thessaloniki, Greece.
authors: Nikolaos
authors: N
authors: Syrmos
mesh_terms: D000328:Adult; D003071:Cognition / Q000187:drug effects*; D004644:Emotions / Q000187:drug effects*; D005260:Female; D050031:Hashimoto Disease / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D008875:Middle Aged; D009483:Neuropsychological Tests; D011446:Prospective Studies; D013960:Thyroid Function Tests; D013974:Thyroxine / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D013974:Thyroxine