title: Association ofNQO1andTNFpolymorphisms with Parkinson's disease: A meta-analysis of 15 genetic association studies.
abstract: Parkinson's disease (PD) is a neurodegenerative movement d'isorder that affects ~2% of the population aged ≥65 years. NAD(P)H-quinone oxidoreductase 1 (NQO1) and tumor necrosis factor-α (TNF-α) are two important factors in the generation of oxidative stress in PD. The aim of the present study was to assess the association ofNQO1and tumor necrosis factor (TNF) polymorphisms with PD. A meta-analysis was performed that included data from 15 studies comprising 2,858 patients and 2,907 healthy controls. The results showed thatTNF-1031 (rs1799964) was significantly associated with PD in the recessive [P=0.0005; odds ratio (OR), 3.19; 95% confidence interval (CI), 1.66-6.13] and additive models (P=0.0006; OR, 3.15; 95% CI, 1.63-3.51). However, there was no significant association inNQO1C609T (rs1800566) andTNF-308 (rs1800629) with PD. To the best of our knowledge, the present study is the first meta-analysis ofNQO1andTNFpolymorphisms with PD demonstrating thatTNF-1031 polymorphism may be a risk factor for PD under either the recessive or additive models. However, the meta-analyses did not support the involvement ofNQO1C609T andTNF-308 in the risk of PD.
authors: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors: Dongjun
authors: D
authors: Dai
authors: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors: Peipei
authors: P
authors: Lin
authors: Department of Neurology, 148 Central Hospital of PLA, Zibo, Shandong 255300, P.R. China.
authors: Yunliang
authors: Y
authors: Wang
authors: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors: Xingyu
authors: X
authors: Zhou
authors: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors: Jianmin
authors: J
authors: Tao
authors: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors: Danjie
authors: D
authors: Jiang
authors: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors: Hanlin
authors: H
authors: Zhou
authors: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors: Ping
authors: P
authors: Ru
authors: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors: Guanghui
authors: G
authors: Pan
authors: Department of Neurology, 148 Central Hospital of PLA, Zibo, Shandong 255300, P.R. China.
authors: Jinfeng
authors: J
authors: Li
authors: Department of Neurology, 148 Central Hospital of PLA, Zibo, Shandong 255300, P.R. China.
authors: Yuzheng
authors: Y
authors: Zhang
authors: Department of Neurology, 148 Central Hospital of PLA, Zibo, Shandong 255300, P.R. China.
authors: Honglei
authors: H
authors: Yin
authors: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors: Shiwei
authors: S
authors: Duan
keywords: NAD(P)H-quinone oxidoreductase 1 C609T; Parkinson’s disease; meta-analysis; tumor necrosis factor-1031; tumor necrosis factor-308