title: A supramolecular strategy for self-mobile adsorption sites in affinity membrane.
abstract: Disclosed here is the design of a novel supramolecular membrane with self-mobile adsorption sites for biomolecules purification. In the 3D micropore channels of membrane matrix, the ligands are conjugated onto the cyclic compounds in polyrotaxanes for protein adsorption. During membrane filtration, the adsorption sites can rotate and/or slide along the axial chain, which results in the enhanced adsorption capacity. The excellent performance of supra-molecular membrane is related with the dynamic working manner of adsorption sites, which plays a crucial role on avoiding spatial mismatching and short-circuit effect. The supra-molecular strategy described here has general suggestions for the "sites" involved technologies such as catalysis, adsorption, and sensors, which is of broad interest.
authors: State Key Laboratory of Hollow Fiber Membrane Materials and Processes, Tianjin Polytechnic University, Tianjin, 300187, P. R. China.
authors: Ligang
authors: L
authors: Lin
authors: Meimei
authors: M
authors: Dong
authors: Chunyu
authors: C
authors: Liu
authors: Chenjie
authors: C
authors: Wei
authors: Yuanyuan
authors: Y
authors: Wang
authors: Hui
authors: H
authors: Sun
authors: Hui
authors: H
authors: Ye
mesh_terms: D000327:Adsorption; D000818:Animals; D001665:Binding Sites; D002417:Cattle; D007700:Kinetics; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008567:Membranes, Artificial; D008956:Models, Chemical; D015394:Molecular Structure; D011092:Polyethylene Glycols / Q000737:chemistry; D016062:Porosity; D011506:Proteins / Q000737:chemistry*; D043862:Rotaxanes / Q000138:chemical synthesis* / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction; D047391:alpha-Cyclodextrins / Q000737:chemistry
chemical_list: D008024:Ligands; D008567:Membranes, Artificial; D011506:Proteins; D043862:Rotaxanes; D047391:alpha-Cyclodextrins; D012710:Serum Albumin, Bovine; D011092:Polyethylene Glycols; C032613:alpha-cyclodextrin
keywords: adsorption; membranes; polyrotaxanes; proteins; supramolecular structures