title: [Inhibitory activities of 3-trifluoromethyl benzamide derivatives against the entry of H5N1 influenza viruses].
abstract: OBJECTIVE
  To study the inhibitory activities of 3-trifluoromethyl benzamide derivatives against the entry of H5N1 influenza viruses.
  
  
  METHODS
  The lead compound was structurally modified to obtain 3 compounds with inhibitory activities against H5N1 influenza viruses. Specs compound librany was screened and 4 compounds were identified to have such inhibitory activities. The inhibitory activities of these compounds were tested at a celluar level against H5N1 influenza viruses.
  
  
  CONCLUSIONS
  The compounds 1a, 1b, 1e and 1f showed signifcant inhibitory activities against the entry of A/AnHui/1/2005 pseudovirus into the target cells with an IC50 value of 4.7 ± 0.3 µmol/L.
authors: School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. E-mail: zzb24@sina.com.cn.
authors: Zhibo
authors: Z
authors: Zhu
authors: Yun
authors: Y
authors: Cai
authors: Jie
authors: J
authors: Yang
authors: Xianglian
authors: X
authors: Li
authors: Runming
authors: R
authors: Li
authors: Shuwen
authors: S
authors: Liu
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D001549:Benzamides / Q000494:pharmacology*; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000187:drug effects* / Q000502:physiology; D007251:Influenza, Human; D053586:Virus Internalization / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D001549:Benzamides; C037689:benzamide