title: Evaluation of effects of platelet-rich plasma on human facial skin.
abstract: BACKGROUND
  Platelet-rich plasma (PRP) has been used for rapid healing and tissue regeneration in many fields of medicine. This study was conducted to evaluate the effects of PRP application procedure on human facial skin.
  
  
  METHODS
  PRP was applied thrice at 2-week intervals on the face of ten healthy volunteers. It was applied to individual's forehead, malar area, and jaw by a dermaroller, and injected using a 27-gauge injector into the wrinkles of crow's feet. Participants were asked to grade on a scale from 0 to 5 for general appearance, skin firmness-sagging, wrinkle state and pigmentation disorder of their own face before each PRP procedure and 3 months after the last PRP procedure. While volunteers were evaluating their own face, they were also assessed by three different dermatologists at the same time by the same five-point scale.
  
  
  RESULTS
  There was statistically significant difference regarding the general appearance, skin firmness-sagging and wrinkle state according to the grading scale of the patients before and after three PRP applications. Whereas there was only statistically significant difference for the skin firmness-sagging according to the assessment of the dermatologists.
  
  
  CONCLUSIONS
  PRP application could be considered as an effective procedure for facial skin rejuvenation.
authors: Department of Dermatology, School of Medicine, Ondokuz Mayis University , Samsun , Turkey.
authors: Esra Pancar
authors: EP
authors: Yuksel
authors: Gokhan
authors: G
authors: Sahin
authors: Fatma
authors: F
authors: Aydin
authors: Nilgun
authors: N
authors: Senturk
authors: Ahmet Yasar
authors: AY
authors: Turanli
mesh_terms: D000328:Adult; D003357:Cosmetic Techniques; D005145:Face; D006801:Humans; D008875:Middle Aged; D017060:Patient Satisfaction; D053657:Platelet-Rich Plasma; D012060:Rejuvenation; D015595:Skin Aging
keywords: aging skin; effect; platelet-rich plasma