title: [Haplotype analysis of serotonin 2A receptor gene polymorphisms and smoking behavior].
abstract: In this study, the relationship between the haplotypes consisting of single nucleotide polymorphisms (SNPs) of serotonin 2A receptor (5HT2AR) gene (HTR2A) 102T/C (rs6313) and -1438A/G (rs6311) and smoking behavior was studied among 101 smokers and 99 non-smokers. It was shown that the genotypic and allelic frequencies of these polymorphisms were not associated with the smoking behavior. However, according to haplotype analysis, higher haplotype 1 ((-1438G) G-(102)T) frequency was observed in smokers than in non-smokers (P < 0.05). Pairwise D' and gamma2 values between the two SNPs in this study were 0.916 and 0.805, respectively. The two SNPs thus showed strong linkage disequilibrium with each other. This study suggests that 5-HT2AR gene haplotype (G-T) may be related to smoking behavior.
authors: Shin
authors: S
authors: Narita
authors: Kenta
authors: K
authors: Nagahori
authors: Kazuhiko
authors: K
authors: Iwahashi
authors: Maki
authors: M
authors: Numajiri
authors: Eiji
authors: E
authors: Yoshihara
authors: Daisuke
authors: D
authors: Nishizawa
authors: Kazutaka
authors: K
authors: Ikeda
authors: Jun
authors: J
authors: Ishigooka
mesh_terms: D000328:Adult; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics* / Q000378:metabolism; D012907:Smoking / Q000235:genetics*; D055815:Young Adult
chemical_list: D044402:Receptor, Serotonin, 5-HT2A