title: MicroRNAs affect tumor metastasis through regulating epithelial- mesenchymal transition.
abstract: Distant metastasis of tumor cell is a series of continuous, selectable cascades of events regulated by multiple factors and genes. Epithelial-mesenchymal transition (EMT) is a critical step during cancer metastasis. However, the mechanism of EMT in tumor is not yet fully elucidated. MicroRNAs (miRNAs) are a class of non-coding small endogenous RNAs that negatively regulate EMT-related genes at the post-transcriptional level and play critical roles in cancer metastasis. This review mainly focuses on the topics that include the relationship of EMT and tumor metastasis, transcription factors involved in EMT, and the effect of miRNAs on tumor metastasis by targeting the EMT-related transcription factors.
authors: Institute of Biochemistry and Molecular Biology, Ningbo University School of Medicine, Ningbo 315211, China; Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 315211, China;
authors: Lihua
authors: L
authors: Yang
authors: Institute of Biochemistry and Molecular Biology, Ningbo University School of Medicine, Ningbo 315211, China.
authors: Xingkai
authors: X
authors: Shen
authors: Institute of Biochemistry and Molecular Biology, Ningbo University School of Medicine, Ningbo 315211, China; Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 315211, China.
authors: Jingqiu
authors: J
authors: Li
authors: Institute of Biochemistry and Molecular Biology, Ningbo University School of Medicine, Ningbo 315211, China; Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 315211, China.
authors: Jie
authors: J
authors: Yang
authors: Institute of Biochemistry and Molecular Biology, Ningbo University School of Medicine, Ningbo 315211, China; Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 315211, China.
authors: Yanping
authors: Y
authors: Le
authors: Institute of Biochemistry and Molecular Biology, Ningbo University School of Medicine, Ningbo 315211, China; Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 315211, China.
authors: Zhaohui
authors: Z
authors: Gong
mesh_terms: D000818:Animals; D058750:Epithelial-Mesenchymal Transition; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology
chemical_list: D035683:MicroRNAs