title: Malignant phyllodes tumor of the breast with liposarcomatous differentiation and intraductal hyperplasia.
abstract: Phyllodes tumor of the breast is a biphasic fibroepithelial neoplasm. 10 to 20% of phyllodes tumor show malignant transformation, often in the form of stroma, which usually shows fibrosarcomatous differentiation and rarely heterologous sarcomatous elements. Liposarcomatous differentiation is not common among phyllodes tumors. The correct diagnosis of heterologous liposarcomatous differentiation in a malignant PT requires identification of the biphasic component of the tumor. We reported a case of malignant phyllodes tumor which initially transformed into liposarcoma, in addition to a very rare intraductal hyperplasia and flat epithelial atypia. The patient was a 75-year-old woman, with a lump in the left breast without axillary lymphadenopathy. She also have a positive family history of breast carcinoma. She underwent surgery and still alive and disease free after one year.
authors: Department of Pathology, Abderrahmen Mami Hospital, Ariana, Tunisia.
authors: Aïda
authors: A
authors: Ayadi-Kaddour
authors: Department of Pathology, Kef Hospital, EI Kef, Tunisia.
authors: Abdelfatteh
authors: A
authors: Zeddini
authors: Department of Pathology, Abderrahmen Mami Hospital, Ariana, Tunisia.
authors: Emna
authors: E
authors: Braham
authors: Department of Pathology, Abderrahmen Mami Hospital, Ariana, Tunisia.
authors: Olfa
authors: O
authors: Ismail
authors: Department of Pathology, Abderrahmen Mami Hospital, Ariana, Tunisia.
authors: Mona
authors: M
authors: Mlika
authors: Department of Gynecology and Obstetrics, Kef Hospital, EI Kef, Tunisia.
authors: Karim
authors: K
authors: Guelmami
authors: Department of Pathology, Abderrahmen Mami Hospital, Ariana, Tunisia.
authors: Faouzi
authors: F
authors: El Mezni
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D008080:Liposarcoma / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D042361:Mammary Glands, Human / Q000473:pathology*; D008408:Mastectomy; D003557:Phyllodes Tumor / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D018714:Radiotherapy, Adjuvant
keywords: Breast; intraductal hyperplasia; liposarcoma; phyllodes tumor