title: Amelanotic corneally displaced malignant conjunctival melanoma: a case report evaluated with impression cytology.
abstract: Here we describe the case of a 65-year-old Caucasian female who presented with an amelanotic malignant conjunctival melanoma and highlight the clinical and pathological features of this rare entity that displayed exclusive corneal invasive growth without evidence of conjunctival tumors other than primary acquired melanosis. Impression cytology aided in the initial diagnosis. The patient underwent surgical treatment. Histopathology and immunohistochemistry revealed an invasive amelanotic melanoma limited to the cornea and exhibiting S-100, Melan A, and HMB-45 positivity. The absence of pigmentation delayed early clinical detection and treatment. Awareness of this nonpigmented melanoma is important for early recognition and appropriate management.
authors: Laboratório de Citologia de Impressão, Clínica de Olhos Dr. Moacir Cunha, São Paulo, SP, Brasil.
authors: Jeison de Nadai
authors: Jde N
authors: Barros
authors: Clínica de Olhos Dr. Moacir Cunha.
authors: Márcia
authors: M
authors: Motono
authors: A.C. Camargo Cancer Center, São Paulo, SP, Brasil.
authors: Felipe D'Almeida
authors: FD
authors: Costa
authors: Clínica de Olhos Dr. Moacir Cunha.
authors: Marcelo Carvalho da
authors: MC
authors: Cunha
authors: A.C. Camargo Cancer Center, São Paulo, SP, Brasil.
authors: Martha Motono
authors: MM
authors: Chojniak
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D003230:Conjunctival Neoplasms / Q000737:chemistry / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D058965:MART-1 Antigen / Q000032:analysis; D018328:Melanoma, Amelanotic / Q000737:chemistry / Q000473:pathology*; D058950:Melanoma-Specific Antigens / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D058951:gp100 Melanoma Antigen
chemical_list: D014408:Biomarkers, Tumor; D058965:MART-1 Antigen; C548667:MLANA protein, human; D058950:Melanoma-Specific Antigens; C548637:PMEL protein, human; D009418:S100 Proteins; D058951:gp100 Melanoma Antigen