title: Rapid engineering of versatile molecular logic gates using heterologous genetic transcriptional modules.
abstract: We designed and constructed versatile modular genetic logic gates in bacterial cells. These function as digital logic 1-input Buffer gate, 2-input and 3-input AND gates with one inverted input and integrate multiple chemical input signals in customised logic manners. Such rapidly engineered devices serve to achieve increased sensing signal selectivity.
authors: Centre for Synthetic and Systems Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JR, UK. Baojun.Wang@ed.ac.uk.
authors: Baojun
authors: B
authors: Wang
authors: Martin
authors: M
authors: Buck
mesh_terms: D018053:Arsenites; D001426:Bacterial Proteins / Q000235:genetics; D039301:Computers, Molecular; D004268:DNA-Binding Proteins / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics*; D008128:Logic; D044224:Pseudomonas syringae / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: D018053:Arsenites; D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; C085856:HrpR protein, Pseudomonas syringae; D014157:Transcription Factors; C060789:hrpS protein, Pseudomonas syringae; C015001:arsenite