title: Obesity, metabolic abnormality, and knee osteoarthritis: a cross-sectional study in Korean women.
abstract: BACKGROUND
  This study aimed to analyze the association between knee osteoarthritis and four body size phenotypes defined by the presence or absence of metabolic abnormality and obesity.
  
  
  METHODS
  This was a cross-sectional study using data from 1,549 female participants of the Fifth Korean National Health and Nutrition Examination Survey. Knee osteoarthritis was defined as a Kellgren-Lawrence grade of ≥ 2. Metabolically abnormal state was defined as presence of more than one abnormality among five metabolic risk factors. Obesity was defined using body mass index. Participants were grouped into one of the four body size phenotypes: metabolically healthy normal weight (MHNW), metabolically abnormal but normal weight (MANW), metabolically healthy obesity (MHO), and metabolically abnormal obesity (MAO).
  
  
  RESULTS
  The distribution of each body size phenotype was as follows: MHNW 54.7%, MANW 30.7%, MHO 4.3%, and MAO 10.3%. Prevalence of symptomatic knee osteoarthritis was higher in MANW than in MHNW, and in MAO than in MHO. In multivariable analysis, the association between symptomatic knee osteoarthritis and the body size phenotypes was as follows (OR [95% CI]): MHNW 1.00 (reference), MANW 1.54 (1.15-2.07), MHO 1.61 (0.83-3.13), and MAO 3.47 (2.35-5.14).
  
  
  CONCLUSIONS
  Obesity showed closest association with knee osteoarthritis when accompanied by metabolic abnormality.
authors: Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine , Busan , Republic of Korea.
authors: Sunggun
authors: S
authors: Lee
authors: Tae-Nyun
authors: TN
authors: Kim
authors: Seong-Ho
authors: SH
authors: Kim
authors: Yong-Gil
authors: YG
authors: Kim
authors: Chang-Keun
authors: CK
authors: Lee
authors: Hee-Bom
authors: HB
authors: Moon
authors: Eun-Mi
authors: EM
authors: Koh
authors: Bin
authors: B
authors: Yoo
mesh_terms: D000368:Aged; D044466:Asian People; D015992:Body Mass Index; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging*; D008659:Metabolic Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology*; D008875:Middle Aged; D009749:Nutrition Surveys; D009765:Obesity / Q000000981:diagnostic imaging / Q000453:epidemiology*; D020370:Osteoarthritis, Knee / Q000000981:diagnostic imaging / Q000453:epidemiology*; D010641:Phenotype; D015995:Prevalence; D011859:Radiography; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors
keywords: Knee joints; Metabolic syndrome; Obesity; Osteoarthritis