title: Pneumonitis in Syrian golden hamsters (Mesocricetus auratus) infected with Rio Mamoré virus (family Bunyaviridae, genus Hantavirus).
abstract: Rio Mamoré virus is an etiological agent of hantavirus pulmonary syndrome in South America. The purpose of this study was to determine whether Rio Mamoré virus strain HTN-007 in Syrian golden hamsters is pathogenic. None of 37 adult hamsters infected by intramuscular injection of HTN-007, including 10 animals killed on Day 42 or 43 post-inoculation, exhibited any symptom of disease. Histological abnormalities included severe or moderately severe pneumonitis in 6 (46.2%) of the 13 animals killed on Day 7 or 10 post-inoculation. The primary target of infection in lung was the endothelium of the microvasculature. Collectively, these results indicate that Rio Mamoré virus strain HTN-007 in adult Syrian golden hamsters can cause a nonlethal disease that is pathologically similar to hantavirus pulmonary syndrome.
authors: The University of Texas Medical Branch, Department of Pathology, 301 University Boulevard, Galveston, TX 77555-0609, USA. Electronic address: mamilazz@utmb.edu.
authors: Mary Louise
authors: ML
authors: Milazzo
authors: The University of Texas Medical Branch, Department of Pathology, 301 University Boulevard, Galveston, TX 77555-0609, USA. Electronic address: ejeyzagu@utmb.edu.
authors: Eduardo J
authors: EJ
authors: Eyzaguirre
authors: The University of Texas Medical Branch, Department of Pathology, 301 University Boulevard, Galveston, TX 77555-0609, USA. Electronic address: cfulhors@utmb.edu.
authors: Charles F
authors: CF
authors: Fulhorst
mesh_terms: D000818:Animals; D006224:Cricetinae; D005260:Female; D006476:Orthohantavirus / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D018778:Hantavirus Infections / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D008647:Mesocricetus / Q000821:virology*; D011014:Pneumonia / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D012376:Rodent Diseases / Q000473:pathology / Q000821:virology*
keywords: Hantavirus pulmonary syndrome; Maporal virus; Rio Mamoré virus