title: Adaptive optics optical coherence tomography with dynamic retinal tracking.
abstract: Adaptive optics optical coherence tomography (AO-OCT) is a highly sensitive and noninvasive method for three dimensional imaging of the microscopic retina. Like all in vivo retinal imaging techniques, however, it suffers the effects of involuntary eye movements that occur even under normal fixation. In this study we investigated dynamic retinal tracking to measure and correct eye motion at KHz rates for AO-OCT imaging. A customized retina tracking module was integrated into the sample arm of the 2nd-generation Indiana AO-OCT system and images were acquired on three subjects. Analyses were developed based on temporal amplitude and spatial power spectra in conjunction with strip-wise registration to independently measure AO-OCT tracking performance. After optimization of the tracker parameters, the system was found to correct eye movements up to 100 Hz and reduce residual motion to 10 µm root mean square. Between session precision was 33 µm. Performance was limited by tracker-generated noise at high temporal frequencies.
authors: School of Optometry, Indiana University, Bloomington, IN 47405, USA.
authors: Omer P
authors: OP
authors: Kocaoglu
authors: Physical Sciences, Inc, Andover, MA 01810, USA.
authors: R Daniel
authors: RD
authors: Ferguson
authors: School of Optometry, Indiana University, Bloomington, IN 47405, USA ; Currently with the Department of Ophthalmology & Vision Science, University of California, Davis, CA 95616, USA.
authors: Ravi S
authors: RS
authors: Jonnal
authors: School of Optometry, Indiana University, Bloomington, IN 47405, USA.
authors: Zhuolin
authors: Z
authors: Liu
authors: School of Optometry, Indiana University, Bloomington, IN 47405, USA.
authors: Qiang
authors: Q
authors: Wang
authors: Physical Sciences, Inc, Andover, MA 01810, USA ; Currently with the Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD 20993, USA.
authors: Daniel X
authors: DX
authors: Hammer
authors: School of Optometry, Indiana University, Bloomington, IN 47405, USA.
authors: Donald T
authors: DT
authors: Miller
keywords: (110.1080) Active or adaptive optics; (120.3890) Medical optics instrumentation; (170.0110) Imaging systems; (170.4470) Ophthalmology; (170.4500) Optical coherence tomography; (330.5310) Vision - photoreceptors