title: Bisphenol-A: epigenetic reprogramming and effects on reproduction and behavior.
abstract: Bisphenol A (BPA) is a synthetic compound used in the production of many polycarbonate plastics and epoxy resins. It is one of the most widely produced chemicals in the world today and is found in most canned goods, plastics, and even household dust. Exposure to BPA is almost universal: most people have measurable amounts of BPA in both urine and serum. BPA is similar in structure to estradiol and can bind to multiple targets both inside and outside the nucleus, in effect acting as an endocrine disruptor. Research on BPA exposure has accelerated in the past decade with findings suggesting that perinatal exposure to BPA can negatively impact both male and female reproduction, create alterations in behavior, and act as a carcinogen. BPA can have both short term and long term effects with the latter typically occurring through epigenetic mechanisms such as DNA methylation. This review will draw on both human and animal studies in an attempt to synthesize the literature and examine the effects of BPA exposure on reproduction, behavior, and carcinogenesis with a focus on the potential epigenetic mechanisms by which it acts.
authors: School of Psychology, University of Ottawa, 136 Jean Jacques Lussier, Vanier Hall, Ottawa, ON K1N 6N5, Canada. gerrimileva@gmail.com.
authors: Guergana
authors: G
authors: Mileva
authors: School of Psychology, University of Ottawa, 136 Jean Jacques Lussier, Vanier Hall, Ottawa, ON K1N 6N5, Canada. stephanie.baker@uOttawa.ca.
authors: Stephanie L
authors: SL
authors: Baker
authors: School of Psychology, University of Ottawa, 136 Jean Jacques Lussier, Vanier Hall, Ottawa, ON K1N 6N5, Canada. anne.konkle@uOttawa.ca.
authors: Anne T M
authors: AT
authors: Konkle
authors: School of Psychology, University of Ottawa, 136 Jean Jacques Lussier, Vanier Hall, Ottawa, ON K1N 6N5, Canada. catch@uOttawa.ca.
authors: Catherine
authors: C
authors: Bielajew
mesh_terms: D000818:Animals; D001519:Behavior / Q000187:drug effects; D001559:Benzhydryl Compounds / Q000493:pharmacokinetics / Q000633:toxicity*; D052244:Endocrine Disruptors / Q000493:pharmacokinetics / Q000633:toxicity*; D004781:Environmental Exposure / Q000009:adverse effects; D004785:Environmental Pollutants / Q000493:pharmacokinetics / Q000633:toxicity*; D044127:Epigenesis, Genetic; D006801:Humans; D009369:Neoplasms / Q000139:chemically induced; D010636:Phenols / Q000493:pharmacokinetics / Q000633:toxicity*; D012098:Reproduction / Q000187:drug effects; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D004785:Environmental Pollutants; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds