title: Poststroke neuropsychiatric symptoms: relationships with IL-17 and oxidative stress.
abstract: Stroke variably activates interleukin- (IL-) 17 expression, reduces regulatory T cells, and induces oxidative stress, which may support neurodegeneration. Ischemic stroke patients were screened for depressive symptoms (Center for Epidemiological Studies Depression (CES-D)) and cognitive status (Mini Mental State Examination). Proinflammatory cytokines (IL-17, IL-23, and interferon- [IFN-] γ), anti-inflammatory cytokine IL-10, and lipid hydroperoxide (LPH), a measure of oxidative stress, were assayed from fasting serum. Of 47 subjects (age 71.8 ± 14.4 years, 36% female), 19 had depressive symptoms (CES-D ≥ 16), which was associated with poorer cognitive status (F 1,46 = 8.44, P = 0.006). IL-17 concentrations did not differ between subjects with and without depressive symptoms (F 1,46 = 8.44, P = 0.572); however, IL-17 was associated with poorer cognitive status in subjects with depressive symptoms (F 1,46 = 9.29, P = 0.004). In those subjects with depressive symptoms, IL-17 was associated with higher LPH (ρ = 0.518, P = 0.023) and lower IL-10 (ρ = -0.484, P = 0.036), but not in those without. In conclusion, poststroke depressive symptoms may be associated with cognitive vulnerability to IL-17 related pathways, involving an imbalance between proinflammatory and anti-inflammatory activity and increased oxidative stress.
authors: Neuropsychopharmacology Research Group, Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5 ; Department of Psychiatry, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5 ; Canadian Partnership for Stroke Recovery, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5 ; Division of Cognitive Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada M4N 3M5 ; L.C. Campbell Cognitive Neurology Research Unit, Sunnybrook Research Institute, Toronto, ON, Canada M4N 3M5.
authors: W
authors: W
authors: Swardfager
authors: Neuropsychopharmacology Research Group, Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5 ; Department of Psychiatry, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5 ; Canadian Partnership for Stroke Recovery, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5 ; Department of Psychiatry, University of Toronto, 250 College Street, 8th Floor, Toronto, ON, Canada M5T 1R8.
authors: N
authors: N
authors: Herrmann
authors: Department of Psychiatry, University of Toronto, 250 College Street, 8th Floor, Toronto, ON, Canada M5T 1R8.
authors: A C
authors: AC
authors: Andreazza
authors: Division of Cognitive Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada M4N 3M5.
authors: R H
authors: RH
authors: Swartz
authors: Neuropsychopharmacology Research Group, Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5.
authors: M M
authors: MM
authors: Khan
authors: Canadian Partnership for Stroke Recovery, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5 ; Division of Cognitive Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada M4N 3M5 ; L.C. Campbell Cognitive Neurology Research Unit, Sunnybrook Research Institute, Toronto, ON, Canada M4N 3M5.
authors: S E
authors: SE
authors: Black
authors: Neuropsychopharmacology Research Group, Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5 ; Department of Psychiatry, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5 ; Canadian Partnership for Stroke Recovery, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5 ; Department of Psychiatry, University of Toronto, 250 College Street, 8th Floor, Toronto, ON, Canada M5T 1R8.
authors: K L
authors: KL
authors: Lanctôt
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003072:Cognition Disorders / Q000150:complications; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood; D003863:Depression / Q000150:complications; D005260:Female; D006801:Humans; D007249:Inflammation; D020381:Interleukin-17 / Q000097:blood*; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D001523:Mental Disorders / Q000150:complications*; D008875:Middle Aged; D009422:Nervous System Diseases / Q000150:complications*; D018384:Oxidative Stress; D020521:Stroke / Q000150:complications* / Q000503:physiopathology*
chemical_list: D016207:Cytokines; D020381:Interleukin-17; D008054:Lipid Peroxides