title: [Chlamydia trachomatis proteasome protein as one of the significant pathogenicity factors of exciter].
abstract: Sex-related infections are a global problem. Such infections may lead to acute or chronic diseases. Chlamydia trachomatis is a dangerous and widespread pathogenicity factor that is not sensitive to conventional drugs and has no obvious symptoms. Protein CPAF is leading factor of pathogenesis. This protein inhibits the signaling pathways of host cell and supports long survival of the pathogen in the host cell. The goal of this work was to review general properties of the proteasome Chlamydia protein CPAF, its functions, and role in pathology. The role of protein CPAF in the anti-chlamydia immune reaction is discussed. The prospects of the development of promising anti-chlamydia vaccine, as well as new effective anti-chlamydia drugs are also discussed.
authors: D Iu
authors: DIu
authors: Davydov
authors: N A
authors: NA
authors: Zigangirova
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D001428:Bacterial Vaccines / Q000235:genetics / Q000276:immunology / Q000627:therapeutic use; D002690:Chlamydia Infections / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control; D002692:Chlamydia trachomatis / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000472:pathogenicity*; D010450:Endopeptidases / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D050296:Microbial Viability / Q000235:genetics / Q000276:immunology; D046988:Proteasome Endopeptidase Complex / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology
chemical_list: D001426:Bacterial Proteins; D001428:Bacterial Vaccines; D010450:Endopeptidases; D046988:Proteasome Endopeptidase Complex; C425923:CPA factor