title: Serum levels of resistin, adiponectin, and apelin in gastroesophageal cancer patients.
abstract: The aim of the study was the investigation of relationship between cachexia syndrome and serum resistin, adiponectin, and apelin in patients with gastroesophageal cancer (GEC).
  
  
  METHODS
  Adipocytokines concentrations were measured in sera of 85 GEC patients and 60 healthy controls. They were also evaluated in tumor tissue and appropriate normal mucosa of 38 operated cancer patients.
  
  
  RESULTS
  Resistin and apelin concentrations were significantly higher in GEC patients than in the controls. The highest resistin levels were found in cachectic patients and in patients with distant metastasis. Serum adiponectin significantly decreased in GEC patients with regional and distant metastasis. Serum apelin was significantly higher in cachectic patients than in the controls. Apelin was positively correlated with hsCRP level. Resistin and apelin levels increased significantly in tumor tissues. Weak positive correlations between adipocytokines levels in serum and in tumor tissue were observed.
  
  
  CONCLUSIONS
  Resistin is associated with cachexia and metastasis processes of GEC. Reduction of serum adiponectin reflects adipose tissue wasting in relation to GEC progression. Correlation of apelin with hsCRP can reflect a presumable role of apelin in systemic inflammatory response in esophageal and gastric cancer.
authors: Department of Gastrointestinal and General Surgery, University of Medicine, Sklodowska-Curie 66, 50-369 Wroclaw, Poland.
authors: Dorota
authors: 0000-0002-1377-5601
authors: D
authors: Diakowska
authors: Department of Gastrointestinal and General Surgery, University of Medicine, Sklodowska-Curie 66, 50-369 Wroclaw, Poland.
authors: Krystyna
authors: K
authors: Markocka-Mączka
authors: Department of Gastrointestinal and General Surgery, University of Medicine, Sklodowska-Curie 66, 50-369 Wroclaw, Poland.
authors: Piotr
authors: P
authors: Szelachowski
authors: Department of Gastrointestinal and General Surgery, University of Medicine, Sklodowska-Curie 66, 50-369 Wroclaw, Poland.
authors: Krzysztof
authors: K
authors: Grabowski
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D000073861:Apelin; D014408:Biomarkers, Tumor / Q000097:blood*; D002100:Cachexia / Q000097:blood / Q000175:diagnosis / Q000473:pathology; D002277:Carcinoma / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D052243:Resistin / Q000097:blood*; D013274:Stomach Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000473:pathology
chemical_list: C115436:APLN protein, human; D052242:Adiponectin; D000073861:Apelin; D014408:Biomarkers, Tumor; D036341:Intercellular Signaling Peptides and Proteins; D052243:Resistin