title: Oral administration of squid lecithin-transphosphatidylated phosphatidylserine improves memory impairment in aged rats.
abstract: Recently, lecithin-derived phosphatidylserine (PS), which originates from marine life, has received much attention as a viable alternative to bovine cerebral cortex PS. In this study, the use of squid phosphatidylcholine-transphosphatidylated PS (SQ-PS) was evaluated through examination of its ameliorating effects on age-associated learning and memory deficits in rats. Aged rats were orally administered SQ-PS (10, 20, or 50 mg/kg per day) once a day for seven days 30 min prior to behavioral assessment in a Morris water maze. SQ-PS administration produced significant dose-dependent improvements in escape latency for finding the platform in the Morris water maze in the aged rats even though Soy-PS administration also exhibited comparable improvements with SQ-PS. Biochemical alterations in the hippocampal cholinergic system, including changes in choline acetyltransferase and acetylcholinesterase immunoreactivity, were consistent with the behavioral results. In addition, SQ-PS treatment significantly restored age-associated decreases of choline transporter and muscarinic acetylcholine receptor type 1 mRNA expression in the hippocampus. These results demonstrate that orally administered SQ-PS dose-dependently aids in the improvement of memory deficits that occur during normal aging in rats. This suggests that SQ-PS may be a useful therapeutic agent in the treatment of diminished memory function in elderly people.
authors: Acupuncture and Meridian Science Research Center, Kyung Hee University, Seoul, 130-701, Republic of Korea.
authors: Bombi
authors: B
authors: Lee
authors: Acupuncture and Meridian Science Research Center, Kyung Hee University, Seoul, 130-701, Republic of Korea; BK21 PLUS Korean Medicine Science Center, College of Korean Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea.
authors: Bong-Jun
authors: BJ
authors: Sur
authors: Glonet BU, Doosan Co., Yongin-si, Gyeonggi-do 448-795, Republic of Korea.
authors: Jeong-Jun
authors: JJ
authors: Han
authors: Acupuncture and Meridian Science Research Center, Kyung Hee University, Seoul, 130-701, Republic of Korea; BK21 PLUS Korean Medicine Science Center, College of Korean Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea.
authors: Insop
authors: I
authors: Shim
authors: Korea Basic Science Institute Chuncheon Branch, Gangwon-do 200-701, Republic of Korea.
authors: Song
authors: S
authors: Her
authors: Dept. of Meridian Medical Science, Graduate School of Kyung Hee University, Gyeonggi-do 448-795, Republic of Korea.
authors: Yang-Seok
authors: YS
authors: Lee
authors: Acupuncture and Meridian Science Research Center, Kyung Hee University, Seoul, 130-701, Republic of Korea; BK21 PLUS Korean Medicine Science Center, College of Korean Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea.
authors: Hye-Jung
authors: HJ
authors: Lee
authors: Acupuncture and Meridian Science Research Center, Kyung Hee University, Seoul, 130-701, Republic of Korea; BK21 PLUS Korean Medicine Science Center, College of Korean Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea. Electronic address: dhhahm@khu.ac.kr.
authors: Dae-Hyun
authors: DH
authors: Hahm
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000284:Administration, Oral; D000367:Age Factors; D000818:Animals; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D049832:Decapodiformes / Q000737:chemistry*; D004195:Disease Models, Animal; D005106:Exploratory Behavior / Q000187:drug effects; D005786:Gene Expression Regulation / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects / Q000201:enzymology; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D026901:Membrane Transport Proteins / Q000235:genetics; D008569:Memory Disorders / Q000178:diet therapy* / Q000503:physiopathology; D010718:Phosphatidylserines / Q000008:administration & dosage*; D011597:Psychomotor Performance / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012153:Retention, Psychology / Q000187:drug effects; D013025:Glycine max / Q000737:chemistry
chemical_list: D026901:Membrane Transport Proteins; D010718:Phosphatidylserines; C065637:choline transporter; D002795:Choline O-Acetyltransferase; D000110:Acetylcholinesterase
keywords: Aging; Cholinergic system; Memory; Phosphatidylserine; Squid