title: Anti-asialo-GM1 and GD1a variant of Miller Fisher variant of Guillain-Barré Syndrome.
abstract: We present a woman with acute onset of bilateral ophthalmoparesis and ataxia occurring 4 weeks after gastroenteritis. Serum antibody titers against asialo-GM1 and GD1a, typically associated with inflammatory axonal neuropathies, were elevated but titers against anti-GQ1b, the most commonly found antibody found in the Miller Fisher variant of Guillain-Barre syndrome were not. No other etiology for ophthalmoparesis was found despite extensive patient evaluation. Intravenous immunoglobulin was administered, and the patient gradually improved over subsequent months. This case is unique for its antiganglioside antibody profile associated with Miller Fisher syndrome.
authors: Department of Ophthalmology (MLM, AEBP, US, SY, AGL), Houston Methodist Hospital, Houston, Texas; Baylor College of Medicine (NL, AGL), Houston, Texas; Departments of Ophthalmology, Neurology, and Neurosurgery (AGL), Weill Cornell Medical College, Houston, Texas; UTMB (AGL), Galveston, Texas and the UTMD Anderson Cancer Center (AGL), Houston, Texas; and University of Iowa Hospitals and Clinics (AGL), Iowa City, Iowa.
authors: Michael L
authors: ML
authors: Morgan
authors: Nathan
authors: N
authors: Law
authors: Angelina
authors: A
authors: Espino Barros Palau
authors: Umair
authors: U
authors: Saeed
authors: Sushma
authors: S
authors: Yalmanchili
authors: Andrew G
authors: AG
authors: Lee
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D005677:G(M1) Ganglioside / Q000276:immunology*; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D019846:Miller Fisher Syndrome / Q000097:blood*
chemical_list: D001323:Autoantibodies; D005732:Gangliosides; C021298:ganglioside, GD1a; D005677:G(M1) Ganglioside; C018835:asialo GM1 ganglioside