title: Carbon-monoxide-releasing molecules for the delivery of therapeutic CO in vivo.
abstract: The development of carbon-monoxide-releasing molecules (CORMs) as pharmaceutical agents represents an attractive and safer alternative to administration of gaseous CO. Most CORMs developed to date are transition-metal carbonyl complexes. Although such CORMs have showed promising results in the treatment of a number of animal models of disease, they still lack the necessary attributes for clinical development. Described in this Minireview are the methods used for CORM selection, to date, and how new insights into the reactivity of metal-carbonyl complexes in vivo, together with advances in methods for live-cell CO detection, are driving the design and synthesis of new CORMs, CORMs that will enable controlled CO release in vivo in a spatial and temporal manner without affecting oxygen transport by hemoglobin.
authors: Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge (UK); Present Address: Polymer and Fibre Technology, KTH Royal Institute of Technology, 100 44 Stockholm (Sweden).
authors: Sandra
authors: S
authors: García-Gallego
authors: Gonçalo J L
authors: GJ
authors: Bernardes
mesh_terms: D002248:Carbon Monoxide / Q000378:metabolism*; D015393:Chemistry, Bioinorganic; D016503:Drug Delivery Systems; D006801:Humans; D010777:Photochemistry; D028561:Transition Elements / Q000378:metabolism*
chemical_list: D028561:Transition Elements; D002248:Carbon Monoxide
keywords: bioinorganic chemistry; carbon monoxide; drug delivery; photochemistry; transition metals