title: Fabrication of highly aligned fibrous scaffolds for tissue regeneration by centrifugal spinning technology.
abstract: Centrifugal spinning (C-Spin) is an emerging technology which uses centrifugal force to produce ultrafine fibers. Being a voltage free technique it can overcome the limitations of electrospinning. Owing to the unique characteristic features such as high surface area to volume ratio, porosity, mechanical strength and fiber alignment, centrifugal spun (C-spun) fibrous mat has a wide range of scope in various biomedical applications. Higher degree of fiber alignment can be effortlessly achieved by the C-Spin process. In order to prove the versatility of C-Spin system with respect to fiber alignment, Polycaprolactone (PCL) and gelatin were spun taking them as model polymers. The morphological analysis revealed that highly aligned ultrafine fibers with smooth surface are achieved by C-Spinning. Hydrophilicity, porosity and mechanical property results confirm that the C-spun mat is more suitable for tissue engineering applications. In vitro and in vivo experiments proved that the scaffolds are biocompatible and can be efficiently used as a wound dressing material.
authors: Department of Textile Technology, Anna University, Chennai 600025, India.
authors: Amalorpava Mary
authors: AM
authors: Loordhuswamy
authors: Department of Biomaterials, CSIR-Central Leather Research Institute, Chennai 600020, India.
authors: Venkat Raghavan
authors: VR
authors: Krishnaswamy
authors: Department of Biomaterials, CSIR-Central Leather Research Institute, Chennai 600020, India.
authors: Purna Sai
authors: PS
authors: Korrapati
authors: Department of Textile Technology, Anna University, Chennai 600025, India.
authors: Senthilram
authors: S
authors: Thinakaran
authors: Department of Textile Technology, Anna University, Chennai 600025, India. Electronic address: vrgiridev@yahoo.com.
authors: Giri Dev Venkateshwarapuram
authors: GD
authors: Rengaswami
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002498:Centrifugation; D005260:Female; D005780:Gelatin / Q000737:chemistry; D006801:Humans; D051379:Mice; D041681:NIH 3T3 Cells; D057139:Nanofibers / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D023822:Tissue Engineering / Q000295:instrumentation*; D054457:Tissue Scaffolds / Q000737:chemistry*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; C016240:polycaprolactone; D005780:Gelatin
keywords: Aligned fibers; Centrifugal spinning; PCL/gelatin blends; Tissue engineering; Wound dressing