title: Effect of coastal eutrophication on heavy metal bioaccumulation and oral bioavailability in the razor clam, Sinonovacula constricta.
abstract: As traditional seafoods, the razor clams are widely distributed from tropical to temperate areas. Coastal razor clams are often exposed to eutrophication. Heavy metal contamination is critical for seafood safety. However, how eutrophication affects bioaccumulation and oral bioavailability of heavy metals in the razor clams is unknown. After a four-month field experimental cultivation, heavy metals (Fe, Cu, Ni, V, As, and Pb) could be bioaccumulated by the razor clams (Sinonovacula constricta) through exposure to metals present in water and sediments or in the food chain, and then transferred to human via consumption of razor clams. Bionic gastrointestinal digestion and monolayer liposome extraction are used for metal oral bioavailability (OBA) assessment. The influence of eutrophication on OBA is decreased for Fe and Pb and increased for V. A significant positive linear correlation was observed between the bioaccumulation factors of Fe, Ni, V, and As in razor clams and the coastal eutrophication. These results may be due to the effect of eutrophication on metal species transformation in coastal seawater and subcellular distribution in razor clams. The maximum allowable daily intakes of razor clams are controlled by eutrophication status and the concentration of affinity-liposome As in razor clams.
authors: College of Chemistry and Environment, Minnan Normal University, Zhangzhou 363000, P.R. China.
authors: Tengxiu
authors: T
authors: Tu
authors: College of Chemistry and Environment, Minnan Normal University, Zhangzhou 363000, P.R. China; Fujian Province Key Laboratory of Modern Analytical Science and Separation Technology, P.R. China. Electronic address: lishunxing@mnnu.edu.cn.
authors: Shunxing
authors: S
authors: Li
authors: College of Chemistry and Environment, Minnan Normal University, Zhangzhou 363000, P.R. China.
authors: Lihui
authors: L
authors: Chen
authors: College of Chemistry and Environment, Minnan Normal University, Zhangzhou 363000, P.R. China; Fujian Province Key Laboratory of Modern Analytical Science and Separation Technology, P.R. China.
authors: Fengying
authors: F
authors: Zheng
authors: College of Chemistry and Environment, Minnan Normal University, Zhangzhou 363000, P.R. China; Fujian Province Key Laboratory of Modern Analytical Science and Separation Technology, P.R. China.
authors: Xu-Guang
authors: XG
authors: Huang
mesh_terms: D000818:Animals; D001682:Biological Availability; D049872:Bivalvia / Q000378:metabolism*; D005068:Eutrophication; D019216:Metals, Heavy / Q000032:analysis / Q000378:metabolism / Q000493:pharmacokinetics*; D012623:Seawater / Q000737:chemistry*; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000378:metabolism*
chemical_list: D019216:Metals, Heavy; D014874:Water Pollutants, Chemical
keywords: Eutrophication; Metal bioaccumulation; Metal oral bioavailability; Razor clams; Seafood safety