title: Palladium/copper-catalyzed aerobic intermolecular cyclization of enediyne compounds and alkynes: interrupting cycloaromatization for (4 + 2) cross-benzannulation.
abstract: A tandem coupling-ketooxygenation reaction of readily accessible enediyne-carboxylic compounds with inner alkynes has been developed that utilizes the PdCl2/CuBr2 catalytic system under an O2 atmosphere and assembles a class of isoindolinones and o-acylbenzoic acids. The two oxygen atoms are regioselectively incorporated into enediyne units at the 1- and 6-positions from atmospheric molecular oxygen and H2O, respectively, during the present process. This study uncovered a formal [4C + 2C] benzannulation-diketonization of enediynes and alkynes via a coupling and decoupling strategy.
authors: Department of Chemistry, Zhejiang University , 20 Yugu Road, Hangzhou 310027, China.
authors: Fei
authors: F
authors: Ling
authors: Zexiang
authors: Z
authors: Li
authors: Chenguang
authors: C
authors: Zheng
authors: Xiang
authors: X
authors: Liu
authors: Cheng
authors: C
authors: Ma
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D053281:Enediynes / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D053281:Enediynes; D010165:Palladium; D003300:Copper