title: Effect of iterative reconstruction algorithms on peripheral MDCT angiography virtual histology plaque volumes: have we been overestimating disease burden?
abstract: Our objective was to compare plaque volumes of multidetector computed tomographic images reconstructed using adaptive statistical iterative reconstruction (ASIR), model-based iterative reconstruction (MBIR), and filtered back projection (FBP). We reviewed 25 patients for a total of 50 extremities imaged on the same scanner. Calcified plaque FBP volume (3468.2 ± 2634.8 mm(3)) was higher than ASIR (2548.1 ± 2166.5 mm(3)). Calcified plaque FBP volume was higher than MBIR (mean=2345.7 ± 1935.4 mm(3)). Our findings suggest that traditional FBP methods overestimate disease compared to newer reconstruction methods.
authors: Department of Radiology, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place Box 1234, New York, NY 10029, USA. Electronic address: vivek.patil@mountsinai.org.
authors: Vivek V
authors: VV
authors: Patil
authors: Department of Radiology, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place Box 1234, New York, NY 10029, USA.
authors: Lawrence N
authors: LN
authors: Tanenbaum
authors: Department of Radiology, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place Box 1234, New York, NY 10029, USA.
authors: Robert A
authors: RA
authors: Lookstein
mesh_terms: D000465:Algorithms; D000792:Angiography / Q000379:methods; D017281:Cost of Illness; D006801:Humans; D007479:Iopamidol; D061330:Multidetector Computed Tomography / Q000379:methods*; D058729:Peripheral Arterial Disease / Q000000981:diagnostic imaging; D011856:Radiographic Image Enhancement / Q000379:methods; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014584:User-Computer Interface; D061205:Vascular Calcification / Q000000981:diagnostic imaging*
chemical_list: D007479:Iopamidol
keywords: CTA; Iterative reconstruction; MDCT; Peripheral arterial disease; Virtual histology