title: Expression of somatostatin type-2 and -4 receptor and correlation with histological type in breast cancer.
abstract: BACKGROUND
  Somatostatin is produced by hypothalamic cells and also by tumors. We were interested to evaluate the somatostatin type 2 (SSTR2) and type 4 (SSTR4) receptor expression on a large sample cohort of breast cancer cases.
  
  
  METHODS
  We used two different Tissue Micro Arrays (TMA) to evaluate SSTR2 and SSTR4 distribution. We evaluated the correlation between SSTR2 and SSTR4 expression and 18 tumor cells markers. We also assessed SSTR mRNA expression on an independent breast cancer population and correlated levels of SSTR2 and SSTR4 expression to molecular breast cancer subtypes.
  
  
  RESULTS
  268 tumors were analyzed. The tumor overexpression of estrogen receptor was significantly correlated to the expression of SSTR2 (p=0.05) and SSTR4 (p=0.04). On principal component analysis, SSTR2 subtype characterized the luminal tumor type. On an independent breast cancer population, expression of SSTR2 and SSTR4 are independent from Human Epidermal Growth Factor Receptor 2 (Her2) and correlated with luminal tumors.
  
  
  CONCLUSIONS
  Expression of somatostatin receptors is a marker of luminal breast tumors.
authors: Department of Gynecology-Obstetrics, Tenon Hospital, Paris, France.
authors: Albane
authors: A
authors: Frati
authors: Department of Gynecology-Obstetrics, Tenon Hospital, Paris, France Department of Surgical Oncology, Curie Institute, Paris, France.
authors: Roman
authors: R
authors: Rouzier
authors: Department of Gynecology-Obstetrics, Tenon Hospital, Paris, France.
authors: Bénédicte
authors: B
authors: Lesieur
authors: Department of Gynecology-Obstetrics, Tenon Hospital, Paris, France.
authors: Gabrielle
authors: G
authors: Werkoff
authors: Department of Anatomo-Pathology, Tenon Hospital, Paris, France.
authors: Martine
authors: M
authors: Antoine
authors: Department of Anatomo-Pathology, Tenon Hospital, Paris, France.
authors: Anita
authors: A
authors: Rodenas
authors: Department of Gynecology-Obstetrics, Tenon Hospital, Paris, France.
authors: Emile
authors: E
authors: Darai
authors: Department of Gynecology-Obstetrics, Tenon Hospital, Paris, France Department of Surgical Oncology, Paoli Calmettes Institute, Marseille, France ED 394 - Ecole Doctorale Physiologie Physiopathologie, Paris, France EA 3499 "Transporteurs ABC et Epithéliums Normaux et Tumoraux", Paris, France chereaue@ipc.unicancer.fr.
authors: Elisabeth
authors: E
authors: Chereau
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000737:chemistry* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D025341:Principal Component Analysis; D012333:RNA, Messenger / Q000032:analysis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis; D017481:Receptors, Somatostatin / Q000032:analysis* / Q000235:genetics; D046888:Tissue Array Analysis
chemical_list: D014408:Biomarkers, Tumor; D012333:RNA, Messenger; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D017481:Receptors, Somatostatin; C574734:SSTR2 protein, human; C098681:somatostatin receptor subtype-4; C508053:ERBB2 protein, human
keywords: Breast cancer; immunohistochemistry; luminal tumor; somatostatin receptors