title: The protective effects of dexmedetomidine on liver injury-induced myocardial ischemia reperfusion.
abstract: OBJECTIVE
  The aim of this study was to evaluate the effect of dexmedetomidine (100 µg/kg-ip) on liver injury-induced myocardial ischemia and reperfusion (IR) in rats.
  
  
  METHODS
  Twenty-four Wistar Albino rats were separated into four groups. There were four experimental groups (Group C (Control; n = 6), Group IR (ischemia-reperfusion, n = 6), Group D (Dexmedetomidine; n = 6) that underwent left thoracotomy and received ip dexmedetomidine without IR administered via 100 µg/kg ip route 30 minutes before ligating the left coronary artery, and Group IR-D (IR-Dexmedetomidine; n = 6). A small plastic snare was threaded through the ligature and placed in contact with the heart. To produce IR, a branch of the left coronary artery was occluded for 30 min followed by two hours of reperfusion. However, after the above procedure, the coronary artery was not occluded or reperfused in the control rats. At the end of the study, liver tissue was obtained for histochemical and immunohistochemical determination.Some part of tissue samples were stained with Masson-trichrome for the evaluation of ultrastructural changes and inducible nitric oxide synthase (iNOS) expression was evaluated in other part of samples for immunohistochemical examination.
  
  
  RESULTS
  Histopathological changes were detected in Group IR when compared with Group C. iNOS expression was found to be increased and stronger particularly in the vascular wall, perisinusoidal space and hepatocytes around vena centralis in this group compared to the control group. Perivascular oedema was detected to be decreased in Group IR-D compared to Group IR. It was also observed that the impairment in the radial arrangement of hepatocytes significantly recovered in Group IR-D. The immunoreactivity was found to be significantly decreased in the assessment of iNOS expression in the same group when compared with Group IR.
  
  
  CONCLUSIONS
  Administration of dexmedetomidine ameliorates liver injury induced by myocardial ischemia and reperfusion (Fig. 8, Ref. 33).
authors: D
authors: D
authors: Erer
authors: A
authors: A
authors: Ozer
authors: M
authors: M
authors: Arslan
authors: G L
authors: GL
authors: Oktar
authors: E
authors: E
authors: Iriz
authors: C
authors: C
authors: Elmas
authors: M H
authors: MH
authors: Zor
authors: T
authors: T
authors: Tatar
authors: G
authors: G
authors: Goktas
mesh_terms: D000818:Animals; D003331:Coronary Vessels / Q000473:pathology; D020927:Dexmedetomidine / Q000494:pharmacology*; D006801:Humans; D008099:Liver / Q000098:blood supply* / Q000473:pathology; D008107:Liver Diseases / Q000150:complications; D008297:Male; D017202:Myocardial Ischemia / Q000150:complications*; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy* / Q000209:etiology; D020011:Protective Agents / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D020011:Protective Agents; D020927:Dexmedetomidine