title: Suppression of sulfoconjugation reduces the protective effect of ortho-aminoazotoluene on hepatocarcinogenesis induced by diethylnitrosamine in mice.
abstract: The effects of ortho-aminoazotoluene on carcinogenic activity of diethylnitrosamine were studied in CBA and ICR mice. Injection of ortho-aminoazotoluene before and after diethylnitrosamine led to a significant reduction of its anticarcinogenic effect, judging from significantly lower level of liver tumors. Pentachlorophenol, inhibitor of sulfotransferase (catalyzing the terminal stage of ortho-aminoazotoluene metabolic activity), stimulated its carcinogenic effect on mouse liver. On the other hand, pentachlorophenol reduced the protective effect of ortho-aminoazotoluene on diethylnitrosamine-induced hepatocarcinogenesis in mice. Presumably, the carcinogenic and anticarcinogenic effects of ortho-aminoazotoluene were realized by its initial form or intermediate (non-sulfated) metabolites.
authors: Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia, pathol@soramn.ru.
authors: V I
authors: VI
authors: Kaledin
authors: S I
authors: SI
authors: Il'nitskaya
authors: N A
authors: NA
authors: Popova
authors: L A
authors: LA
authors: Bogdanova
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D063646:Carcinogenesis / Q000187:drug effects*; D004052:Diethylnitrosamine; D005260:Female; D008099:Liver / Q000737:chemistry / Q000201:enzymology / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D008808:Mice, Inbred CBA; D008813:Mice, Inbred ICR; D010416:Pentachlorophenol / Q000494:pharmacology; D015238:Sulfotransferases / Q000037:antagonists & inhibitors / Q000378:metabolism; D009762:o-Aminoazotoluene / Q000494:pharmacology*
chemical_list: D016588:Anticarcinogenic Agents; D004052:Diethylnitrosamine; D010416:Pentachlorophenol; D015238:Sulfotransferases; D009762:o-Aminoazotoluene