title: [Features of the pharmacokinetics of ceftriaxone during the antiorthostatic hypokinesia in rats].
abstract: This study was designed to investigate the effects of simulated microgravity on the plasma kinetics of ceftriaxone in rats. Comparative analysis of pharmacokinetic parameters in control and experimental groups has revealed the influence of antiorthostatic hypokinesia (ANOH) on the pharmacokinetics of ceftriaxone. Decreased level of maximum plasma concentration (C(max)) and bioavailability of ceftriaxone after single intramuscular (IM) injection were revealed in rats with antiorthostatic hypokinesia. The rate of absorption of the drug was higher respectively.
authors: M V
authors: MV
authors: Baranov
authors: E N
authors: EN
authors: Arkhipova
authors: M A
authors: MA
authors: Lebedeva
authors: N N
authors: NN
authors: Khlebnikova
authors: Yu S
authors: YS
authors: Medvedeva
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000493:pharmacokinetics*; D002443:Ceftriaxone / Q000493:pharmacokinetics*; D007103:Immobilization; D051381:Rats; D014893:Weightlessness
chemical_list: D000890:Anti-Infective Agents; D002443:Ceftriaxone