title: Non-operative outcomes in Chiari I malformation patients.
abstract: While postoperative outcomes of Chiari I malformation patients have been well-reported, there is a paucity of literature concerning non-operative management in these patients. We retrospectively identified patients with Chiari I malformation who were not recommended for surgery based on lack of clinical objective findings or inconsistent cough headaches and conducted patient follow-up with a prospective telephone survey. Of the 68 patients (mean age at diagnosis 30.1 ± 17.4 years), 72% were female and 31% were pediatric patients (age at diagnosis ⩽ 18 years). Average follow up was 4.9 ± 2.9 years. Typical presenting symptoms included cough headache, non-specific headache, nausea, ataxia, dysphagia and paresthesias. Overall, 40% of patients who had cough headaches and 61.5% of patients with non-specific headaches reported improvement. The presence of subjective sensory symptoms was significantly associated with less likelihood of cough headache improvement while the presence of a cough headache was also associated with a lower likelihood of improvement in all non-cough symptoms. The pediatric subgroup had a greater rate of improvement with all cases of nausea/emesis and paresthesias improved or resolved at follow-up. Overall 67% of pediatric patients had improved cough headache and 71% had improvement of migraines/diffuse headaches. We found that many symptoms of Chiari I patients from our conservatively managed cohort either improved or remained unchanged over time. However, the presence of cough headaches was a significant negative predictor of concomitant symptom improvement. This further validates the view that patients with cough headaches should be considered for surgical intervention and provides useful information to counsel patients.
authors: Department of Neurosurgery, Tufts Medical Center and Tufts University School of Medicine, 800 Washington Street, Box #178, Boston, MA 02111, USA.
authors: Amy
authors: A
authors: Killeen
authors: Department of Neurosurgery, Tufts Medical Center and Tufts University School of Medicine, 800 Washington Street, Box #178, Boston, MA 02111, USA.
authors: Marie
authors: M
authors: Roguski
authors: Department of Neurosurgery, Tufts Medical Center and Tufts University School of Medicine, 800 Washington Street, Box #178, Boston, MA 02111, USA.
authors: Alexis
authors: A
authors: Chavez
authors: Department of Neurosurgery, Tufts Medical Center and Tufts University School of Medicine, 800 Washington Street, Box #178, Boston, MA 02111, USA.
authors: Carl
authors: C
authors: Heilman
authors: Department of Neurosurgery, Tufts Medical Center and Tufts University School of Medicine, 800 Washington Street, Box #178, Boston, MA 02111, USA. Electronic address: shwang@tuftsmedicalcenter.org.
authors: Steven
authors: S
authors: Hwang
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001139:Arnold-Chiari Malformation / Q000150:complications / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D051270:Headache Disorders, Primary / Q000209:etiology; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000209:etiology; D010292:Paresthesia / Q000209:etiology; D011379:Prognosis; D012189:Retrospective Studies; D012678:Sensation Disorders / Q000209:etiology; D011795:Surveys and Questionnaires; D013689:Telephone; D016896:Treatment Outcome; D014839:Vomiting / Q000209:etiology; D057832:Watchful Waiting; D055815:Young Adult
keywords: Chiari; Conservative therapy; Cough headache; Outcomes; Valsalva