title: Genetic Polymorphisms of the Bovine NOV Gene Are Significantly Associated with Carcass Traits in Korean Cattle.
abstract: The objective of this study was to investigate single nucleotide polymorphisms (SNPs) in the bovine nephroblastoma overexpressed (NOV) gene and to evaluate whether these polymorphisms affect carcass traits in the Korean cattle population. We resequenced to detect SNPs from 24 unrelated individuals and identified 19 SNPs within the full 8.4-kb gene, including the 1.5-kb promoter region. Of these 19 SNPs, four were selected for genotyping based on linkage disequilibrium (LD). We genotyped 429 steers to assess the associations of these four SNPs with carcass traits. Statistical analysis revealed that g.7801T>C and g.8379A>C polymorphisms in the NOV gene were associated with carcass weight (p = 0.012 and 0.008, respectively), and the g.2005A>G polymorphism was associated with the back fat thickness (BF) trait (p = 0.0001). One haplotype of the four SNPs (GGTA) was significantly associated with BF (p = 0.0005). Our findings suggest that polymorphisms in the NOV gene may be among the important genetic factors affecting carcass yield in beef cattle.
authors: Animal Genome and Bioinformatics Division, National Institute of Animal Science, Rural Development Administration, Chuksan gil 77, Kwonsun-gu, Suwon, Korea.
authors: B S
authors: BS
authors: Kim
authors: Animal Genome and Bioinformatics Division, National Institute of Animal Science, Rural Development Administration, Chuksan gil 77, Kwonsun-gu, Suwon, Korea.
authors: S C
authors: SC
authors: Kim
authors: Animal Genome and Bioinformatics Division, National Institute of Animal Science, Rural Development Administration, Chuksan gil 77, Kwonsun-gu, Suwon, Korea.
authors: C M
authors: CM
authors: Park
authors: Animal Genome and Bioinformatics Division, National Institute of Animal Science, Rural Development Administration, Chuksan gil 77, Kwonsun-gu, Suwon, Korea.
authors: S H
authors: SH
authors: Lee
authors: Animal Genome and Bioinformatics Division, National Institute of Animal Science, Rural Development Administration, Chuksan gil 77, Kwonsun-gu, Suwon, Korea.
authors: S H
authors: SH
authors: Cho
authors: Animal Genome and Bioinformatics Division, National Institute of Animal Science, Rural Development Administration, Chuksan gil 77, Kwonsun-gu, Suwon, Korea.
authors: N K
authors: NK
authors: Kim
authors: Animal Genome and Bioinformatics Division, National Institute of Animal Science, Rural Development Administration, Chuksan gil 77, Kwonsun-gu, Suwon, Korea.
authors: G W
authors: GW
authors: Jang
authors: Animal Genome and Bioinformatics Division, National Institute of Animal Science, Rural Development Administration, Chuksan gil 77, Kwonsun-gu, Suwon, Korea.
authors: D H
authors: DH
authors: Yoon
authors: Animal Genome and Bioinformatics Division, National Institute of Animal Science, Rural Development Administration, Chuksan gil 77, Kwonsun-gu, Suwon, Korea.
authors: B S
authors: BS
authors: Yang
authors: Animal Genome and Bioinformatics Division, National Institute of Animal Science, Rural Development Administration, Chuksan gil 77, Kwonsun-gu, Suwon, Korea.
authors: S K
authors: SK
authors: Hong
authors: Animal Genome and Bioinformatics Division, National Institute of Animal Science, Rural Development Administration, Chuksan gil 77, Kwonsun-gu, Suwon, Korea.
authors: H H
authors: HH
authors: Seong
authors: Animal Genome and Bioinformatics Division, National Institute of Animal Science, Rural Development Administration, Chuksan gil 77, Kwonsun-gu, Suwon, Korea.
authors: B H
authors: BH
authors: Choi
keywords: Back Fat Thickness; Carcass Weight; Korean Cattle; NOV Gene; Single Nucleotide Polymorphism