title: Eosinophils count and periprocedural myocardial infarction in patients undergoing percutaneous coronary interventions.
abstract: BACKGROUND
  Eosinophils have been involved in a wide spectrum of pro-inflammatory and pro-thrombotic conditions, with the development of cardiovascular complications in a significant proportion of hypereosinophilic patients. However, no study has so far evaluated the impact of eosinophils levels on periprocedural myocardial infarction (PMI) in patients undergoing non-urgent percutaneous coronary interventions (PCI), that was, then, aim of current study.
  
  
  METHODS
  In a consecutive cohort of patients, myonecrosis biomarkers were dosed at intervals from 6 to 48 h after PCI. Periprocedural myonecrosis was defined as troponin I increase by 3 times the ULN or by 50% of an elevated baseline value, whereas PMI as CKMB increase by 3 times the ULN or 50% of baseline.
  
  
  RESULTS
  Our population is represented by 1543 patients who were divided according to tertiles of absolute eosinophils count (AEC ≤ 0.1; 0.1-0.2; >0.2 × 10ˆ3/ml). Higher AEC was related to male gender (p = 0.002), arterial hypertension (p = 0.02), diabetes (p = 0.001), previous coronary revascularization (p = 0.003 for PCI, p = 0.03 for CABG), treatment with ARBs, beta-blockers, diuretics and ASA (p < 0.001), statins (p = 0.02), calcium antagonists (p = 0.05), glycosylated hemoglobin (p < 0001), creatinine levels (p = 0.001) and platelet count (p = 0.01), while inversely with acute presentation (p < 0.001), glycemia (p = 0.03), HDL-cholesterol and C-reactive protein (p = 0.02). AEC related with multivessel coronary artery disease (p = 0.05), lesion length (p = 0.01), drug eluting stents implantation (p = 0.001) and use of kissing balloon technique (p = 0.05), while inversely to intracoronary thrombus (p < 0.001) and thrombectomy (p = 0.04). AEC did not influence the occurrence of PMI (p = 0.06, adjusted OR [95% CI] = 1.06 [0.86-1.31], p = 0.57) or myonecrosis (p = 0.15, adjusted OR [95% CI] = 1.06 [0.88-1.27], p = 0.53). Results were confirmed at subgroup analysis in higher-risk subsets of patients.
  
  
  CONCLUSIONS
  In patients undergoing non-urgent PCI, eosinophils levels are not associated with the occurrence of periprocedural myocardial infarction or myonecrosis.
authors: Division of Cardiology, Azienda Ospedaliera-Universitaria "Maggiore della Carità", Eastern Piedmont University, Novara, Italy.
authors: Monica
authors: M
authors: Verdoia
authors: Division of Cardiology, Azienda Ospedaliera-Universitaria "Maggiore della Carità", Eastern Piedmont University, Novara, Italy.
authors: Alon
authors: A
authors: Schaffer
authors: Division of Cardiology, Azienda Ospedaliera-Universitaria "Maggiore della Carità", Eastern Piedmont University, Novara, Italy.
authors: Lucia
authors: L
authors: Barbieri
authors: Department of Translational Medicine, Eastern Piedmont University, Novara, Italy.
authors: Fabiola
authors: F
authors: Sinigaglia
authors: Division of Cardiology, Azienda Ospedaliera-Universitaria "Maggiore della Carità", Eastern Piedmont University, Novara, Italy; Department of Translational Medicine, Eastern Piedmont University, Novara, Italy.
authors: Paolo
authors: P
authors: Marino
authors: Department of Cardiology, UMC St Radboud, Nijmegen, The Netherlands.
authors: Harry
authors: H
authors: Suryapranata
authors: Division of Cardiology, Azienda Ospedaliera-Universitaria "Maggiore della Carità", Eastern Piedmont University, Novara, Italy; Department of Translational Medicine, Eastern Piedmont University, Novara, Italy. Electronic address: giuseppe.deluca@maggioreosp.novara.it.
authors: Giuseppe
authors: G
authors: De Luca
mesh_terms: D000368:Aged; D015415:Biomarkers; D002097:C-Reactive Protein / Q000032:analysis; D002317:Cardiovascular Agents / Q000627:therapeutic use; D008076:Cholesterol, HDL / Q000097:blood; D015897:Comorbidity; D003328:Coronary Thrombosis / Q000453:epidemiology / Q000601:surgery; D003404:Creatinine / Q000097:blood; D003920:Diabetes Mellitus / Q000453:epidemiology; D004804:Eosinophils; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000628:therapy; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D062645:Percutaneous Coronary Intervention; D010976:Platelet Count; D012008:Recurrence; D051437:Renal Insufficiency / Q000453:epidemiology; D012189:Retrospective Studies; D012907:Smoking / Q000453:epidemiology; D015607:Stents; D017131:Thrombectomy / Q000706:statistics & numerical data
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D002317:Cardiovascular Agents; D008076:Cholesterol, HDL; D003404:Creatinine; D006442:Glycated Hemoglobin
keywords: Eosinophils count; PCI; Periprocedural myocardial infarction