title: Asymmetric synthesis of first generation molecular motors.
abstract: A general enantioselective route to functionalized first generation molecular motors is described. An enantioselective protonation of the silyl enol ethers of indanones by a Au(I)BINAP complex sets the stage for a highly diastereoselective McMurry coupling as a second enhancement step for enantiomeric excess. In this way various functionalized overcrowded alkenes could be synthesized in good yields (up to 78%) and good to excellent enantiomeric excess (85% ee->98% ee) values.
authors: Centre for System Chemistry, Stratingh Institute for Chemistry, Faculty of Mathematics and Natural Sciences, University of Groningen , Nijenborgh 4, 9747AG Groningen, The Netherlands.
authors: Thomas M
authors: TM
authors: Neubauer
authors: Thomas
authors: T
authors: van Leeuwen
authors: Depeng
authors: D
authors: Zhao
authors: Anouk S
authors: AS
authors: Lubbe
authors: Jos C M
authors: JC
authors: Kistemaker
authors: Ben L
authors: BL
authors: Feringa