title: RNA interference: a promising therapy for gastric cancer.
abstract: Gastric cancer (GC) remains a virtually incurable disease when metastatic and requires early screening tools for detection of early tumor stages. Therefore, finding effective strategies for prevention or recurrence of GC has become a major overall initiative. RNA-interference (RNAi) is an innovative technique that can significantly regulate the expression of oncogenes involved in gastric carcinogenesis, thus constituting a promising epigenetic approach to GC therapy. This review presents recent advances concerning the promising biomolecular mechanism of RNAi for GC treatment.
authors: Department of Medicine, Gastroenterology Division, Federal University of Sao Paulo, Sao Paulo, Brazil E-mail : aledson.felipe@gmail.com.
authors: Aledson Vitor
authors: AV
authors: Felipe
authors: Juliana
authors: J
authors: Oliveira
authors: Paula Yun Joo
authors: PY
authors: Chang
authors: Andrea Aparecida de Fatima Souza
authors: AA
authors: Moraes
authors: Tiago Donizetti
authors: TD
authors: da Silva
authors: Vanina Monique
authors: VM
authors: Tucci-Viegas
authors: Nora Manoukian
authors: NM
authors: Forones
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000235:genetics; D016207:Cytokines / Q000096:biosynthesis / Q000235:genetics; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000235:genetics / Q000517:prevention & control*; D015513:Oncogene Proteins / Q000096:biosynthesis / Q000235:genetics; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000235:genetics* / Q000628:therapy*; D014157:Transcription Factors / Q000096:biosynthesis / Q000235:genetics
chemical_list: D016207:Cytokines; D015513:Oncogene Proteins; D034741:RNA, Small Interfering; D014157:Transcription Factors