title: Triterpenoids and α-glucosidase inhibitory constituents from Salacia hainanensis.
abstract: Thirteen triterpenoids (1-13), including two new lupane triterpenoids, salacinins A and B (1 and 2), as well as one new friedelane triterpenoid, salacinin C (3), were isolated from the roots and stems of Salacia hainanensis. The structures of new compounds were elucidated by extensive spectroscopic analysis including 1D and 2D NMR, and MS experiments. Compound 1 possesses rare 2,3-seco-lupane skeleton. Compounds 4, 6 and 7 showed inhibitory effects on α-glucosidase in vitro.
authors: School of Pharmacy, Fudan University, 826 Zhang Heng Road, Shanghai 201203, People's Republic of China.
authors: Mei-Hua
authors: MH
authors: Yu
authors: School of Pharmacy, Fudan University, 826 Zhang Heng Road, Shanghai 201203, People's Republic of China.
authors: Zheng-Feng
authors: ZF
authors: Shi
authors: Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, People's Republic of China.
authors: Bang-Wei
authors: BW
authors: Yu
authors: School of Pharmacy, Fudan University, 826 Zhang Heng Road, Shanghai 201203, People's Republic of China.
authors: En-Hao
authors: EH
authors: Pi
authors: Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, People's Republic of China.
authors: He-Yao
authors: HY
authors: Wang
authors: School of Pharmacy, Fudan University, 826 Zhang Heng Road, Shanghai 201203, People's Republic of China.
authors: Ai-Jun
authors: AJ
authors: Hou
authors: School of Pharmacy, Fudan University, 826 Zhang Heng Road, Shanghai 201203, People's Republic of China. Electronic address: chunlei@fudan.edu.cn.
authors: Chun
authors: C
authors: Lei
mesh_terms: D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D049918:Salacia / Q000737:chemistry* / Q000378:metabolism*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification; D000520:alpha-Glucosidases; D053978:Pentacyclic Triterpenes
chemical_list: D065089:Glycoside Hydrolase Inhibitors; D014315:Triterpenes; D000520:alpha-Glucosidases; C421805:friedelane; C000597511:salacinin A; C000597512:salacinin B; C480546:lupane; D053978:Pentacyclic Triterpenes
keywords: Friedelane; Lupine; Salacia hainanensis; α-Glucosidase