title: Comparison of the performance of log-logistic regression and artificial neural networks for predicting breast cancer relapse.
abstract: BACKGROUND
  Breast cancer is the most common cancers in female populations. The exact cause is not known, but is most likely to be a combination of genetic and environmental factors. Log-logistic model (LLM) is applied as a statistical method for predicting survival and it influencing factors. In recent decades, artificial neural network (ANN) models have been increasingly applied to predict survival data. The present research was conducted to compare log-logistic regression and artificial neural network models in prediction of breast cancer (BC) survival.
  
  
  METHODS
  A historical cohort study was established with 104 patients suffering from BC from 1997 to 2005. To compare the ANN and LLM in our setting, we used the estimated areas under the receiver-operating characteristic (ROC) curve (AUC) and integrated AUC (iAUC). The data were analyzed using R statistical software.
  
  
  RESULTS
  The AUC for the first, second and third years after diagnosis are 0.918, 0.780 and 0.800 in ANN, and 0.834, 0.733 and 0.616 in LLM, respectively. The mean AUC for ANN was statistically higher than that of the LLM (0.845 vs. 0.744). Hence, this study showed a significant difference between the performance in terms of prediction by ANN and LLM.
  
  
  CONCLUSIONS
  This study demonstrated that the ability of prediction with ANN was higher than with the LLM model. Thus, the use of ANN method for prediction of survival in field of breast cancer is suggested.
authors: Modeling of Noncommunicable Diseases Research Center, Department of Biostatistics and Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran E-mail : gh.roshanaei@umsha.ac.ir.
authors: Javad
authors: J
authors: Faradmal
authors: Ali Reza
authors: AR
authors: Soltanian
authors: Ghodratollah
authors: G
authors: Roshanaei
authors: Reza
authors: R
authors: Khodabakhshi
authors: Amir
authors: A
authors: Kasaeian
mesh_terms: D001943:Breast Neoplasms / Q000401:mortality* / Q000473:pathology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000401:mortality* / Q000473:pathology; D016571:Neural Networks, Computer; D011379:Prognosis; D012372:ROC Curve