title: [Central blood pressure and vascular damage].
abstract: OBJECTIVE
  The aim of this study was to assess the relationship between central blood pressure and vascular damage.
  
  
  METHODS
  This cross-sectional study involved 393 never treated hypertensive patients (166 women). Clinical blood pressure (BP), 24h blood pressure (BP24h) and central blood pressure (CBP) were measured. Vascular organ damage (VOD) was assessed by calculating the albumin/creatinine ratio (ACR), wave pulse pressure velocity and echocardiographic left ventricular mass index (LVMI).
  
  
  RESULTS
  Patients with VOD had higher values of BP, BP24h, and CBP than patients without ACR. When comparing several systolic BP, systolic BP24h had a higher linear correlation with CBP (Z Steiger test: 2.26; P=.02) and LVMI (Z Steiger test: 3.23; P=.01) than PAC. In a multiple regression analysis corrected by age, sex and metabolic syndrome, all pressures were related with VOD but systolic BP24h showed the highest correlation. In a logistic regression analysis, having the highest tercile of systolic BP24h was the stronger predictor of VOD (multivariate odds ratio: 3.4; CI 95%: 2.5-5.5, P=.001).
  
  
  CONCLUSIONS
  CBP does not have more correlation with VOD than other measurements of peripheral BP. Systolic BP24h is the BP measurement that best predicts VOD.
authors: Unidad de Hipertensión y Riesgo Vascular, Servicio de Medicina Interna, Hospital de Sagunto, Agencia Valenciana de Salud, Sagunto, Valencia, España.
authors: Francisco
authors: F
authors: Pérez-Lahiguera
authors: Unidad de Hipertensión y Riesgo Vascular, Servicio de Medicina Interna, Hospital de Sagunto, Agencia Valenciana de Salud, Sagunto, Valencia, España; Facultad de Ciencias de la Salud, Universidad Cardenal Herrera, Castellón, España.
authors: Enrique
authors: E
authors: Rodilla
authors: Unidad de Hipertensión y Riesgo Vascular, Servicio de Medicina Interna, Hospital de Sagunto, Agencia Valenciana de Salud, Sagunto, Valencia, España.
authors: José Antonio
authors: JA
authors: Costa
authors: Unidad de Hipertensión y Riesgo Vascular, Servicio de Medicina Interna, Hospital de Sagunto, Agencia Valenciana de Salud, Sagunto, Valencia, España; Departamento de Medicina, Universidad de Valencia, Valencia, España. Electronic address: pascual_jma@gva.es.
authors: José María
authors: JM
authors: Pascual
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000209:etiology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D014463:Ultrasonography; D014652:Vascular Diseases / Q000175:diagnosis / Q000209:etiology*; D059289:Vascular Stiffness
keywords: 24-hours blood pressure; Central blood pressure; Daño vascular; Presión arterial central; Presión arterial de 24 horas; Vascular organ damage