title: [Time-related expression of IL-6, IL-8 and TNF-alpha following explosive injury to rabbit's chest].
abstract: OBJECTIVE
  To explore the relationship between the expression changes of cytokines, interleukin-6 (IL-6), interleukin-8(IL-8), and tumor necrosis factor-alpha (TNF-alpha), and the wound time following explosive injury to rabbit's chest.
  
  
  METHODS
  The rabbit's model of explosive injury was established. The expression levels of IL-6, IL-8 and TNF-alpha in the plasma were detected by ELISA method at different wound time (0.5-12h).
  
  
  RESULTS
  The level of IL-6 increased at 3h after wounding and reached peak at 6 h. The level of IL-8 increased at 1 h and reached peak at 6 h. The level of TNF-alpha increased at 0.5 h and reached peak at 3 h.
  
  
  CONCLUSIONS
  IL-6, IL-8 and TNF-alpha have a time-related expression after explosive injury.
authors: Meng
authors: M
authors: He
authors: Li-Min
authors: LM
authors: Dong
authors: Xiao-Bin
authors: XB
authors: Hou
mesh_terms: D000818:Animals; D004797:Enzyme-Linked Immunosorbent Assay; D005107:Explosions; D015850:Interleukin-6 / Q000378:metabolism*; D016209:Interleukin-8 / Q000378:metabolism*; D011817:Rabbits; D013898:Thoracic Injuries / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha