title: Foxp3 expression in deep rectosigmoid endometriosis lesions and its association with chronic pelvic pain.
abstract: Endometriosis is a benign gynecological disease that is related to immune response alterations. T regulatory cells modulate immune response, and Foxp3 seems to be the best marker of these cells. This study evaluated Foxp3 mRNA expression in eutopic endometrium from women with endometriosis and healthy controls, and its expression in deep rectosigmoid endometriosis lesions, one of the more aggressive types of the disease. Foxp3 expression was higher in lesions than in eutopic endometrium in the two groups. Moreover, eutopic endometrium Foxp3 expression of women with endometriosis was associated with chronic pelvic pain and cyclic urinary pain.
authors: Department of Obstetrics and Gynecology, Faculty of Medicine, University of São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 255, Cerqueira César CEP 05403-000, Sao Paulo, Brazil; Jewish Teaching and Research Institute, Albert Einstein Hospital, Avenida Albert Einstein 627, Morumbi CEP 05652-900, Sao Paulo, Brazil. Electronic address: sergiopodgaec@me.com.
authors: Sergio
authors: S
authors: Podgaec
authors: Medical Investigation Laboratory #51, Faculty of Medicine, University of São Paulo, Av. Dr. Arnaldo, 455, Cerqueira César CEP 01246903, Sao Paulo, Brazil. Electronic address: denisedna@hotmail.com.
authors: Denise Frediani
authors: DF
authors: Barbeiro
authors: Jewish Teaching and Research Institute, Albert Einstein Hospital, Avenida Albert Einstein 627, Morumbi CEP 05652-900, Sao Paulo, Brazil. Electronic address: barbara.gsilva@einstein.br.
authors: Bárbara Yasmin
authors: BY
authors: Gueuvoghlanian-Silva
authors: Department of Obstetrics and Gynecology, Faculty of Medicine, University of São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 255, Cerqueira César CEP 05403-000, Sao Paulo, Brazil. Electronic address: pbellelis@gmail.com.
authors: Patrick
authors: P
authors: Bellelis
authors: Department of Obstetrics and Gynecology, Faculty of Medicine, University of São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 255, Cerqueira César CEP 05403-000, Sao Paulo, Brazil. Electronic address: msabrao@me.com.
authors: Maurício Simões
authors: MS
authors: Abrão
authors: Department of Obstetrics and Gynecology, Faculty of Medicine, University of São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 255, Cerqueira César CEP 05403-000, Sao Paulo, Brazil. Electronic address: edmund@baracat.com.br.
authors: Edmund Chada
authors: EC
authors: Baracat
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D059350:Chronic Pain / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D004715:Endometriosis / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D005260:Female; D051858:Forkhead Transcription Factors / Q000096:biosynthesis* / Q000276:immunology; D005786:Gene Expression Regulation / Q000276:immunology*; D006801:Humans; D017699:Pelvic Pain / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism / Q000473:pathology
chemical_list: C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors
keywords: Endometriosis; Endometrium; Forkhead transcription factor – Foxp3; T regulatory cells