title: Pharmacological modulation of monocytes and macrophages.
abstract: Mononuclear phagocytes are major players in diverse pathological conditions which include chronic inflammatory diseases, infection, autoimmunity, atherosclerosis, metabolic disorders, and cancer. Plasticity is a fundamental property of cells of the monocyte-macrophage lineage and a variety of modulators profoundly affect monocytes and macrophages. Tumor-associated macrophages (TAMs) provide a paradigm for macrophage plasticity and anticancer therapeutic modalities (chemotherapy, radiotherapy, and immunotherapy) profoundly affect their function. The development of innovative strategies targeting cells of the monocyte-macrophage lineage may pave the way to innovative therapies for a wide range of diseases.
authors: Humanitas Clinical and Research Center, via Manzoni 56, 20089 Rozzano, Italy; Department of Biotechnology and Translational Medicine, University of Milan, 20089 Rozzano, Italy. Electronic address: alberto.mantovani@humanitasresearch.it.
authors: Alberto
authors: A
authors: Mantovani
authors: Humanitas Clinical and Research Center, via Manzoni 56, 20089 Rozzano, Italy.
authors: Annunciata
authors: A
authors: Vecchi
authors: Humanitas Clinical and Research Center, via Manzoni 56, 20089 Rozzano, Italy.
authors: Paola
authors: P
authors: Allavena
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D019070:Cell Lineage; D002633:Chemotaxis / Q000187:drug effects; D015195:Drug Design; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology*; D008262:Macrophage Activation / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology / Q000528:radiation effects; D009000:Monocytes / Q000187:drug effects* / Q000276:immunology / Q000528:radiation effects; D009369:Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D010641:Phenotype
chemical_list: D000970:Antineoplastic Agents; D007155:Immunologic Factors