title: A napthelene-pyrazol conjugate: Al(III) ion-selective blue shifting chemosensor applicable as biomarker in aqueous solution.
abstract: A newly synthesized and crystalographically characterized napthelene–pyrazol conjugate, 1-[(5-phenyl-1H-pyrazole-3-ylimino)-methyl]-naphthalen-2-ol (HL) behaves as an Al(III) ion-selective chemosensor through internal charge transfer (ICT)-chelation-enhanced fluorescence (CHEF) processes in 100 mM HEPES buffer (water–DMSO 5:1, v/v) at biological pH with almost no interference of other competitive ions. This mechanism is readily studied from electronic, fluorimetric and (1)H NMR titration. The probe (HL) behaved as a highly selective fluorescent sensor for Al(III) ions as low as 31.78 nM within a very short response time (15–20 s). The sensor (HL), which has no cytotoxicity, is also efficient in detecting the distribution of Al(III) ions in HeLa cells via image development under fluorescence microscope.
authors: Department of Chemistry, Burdwan University, Golapbag, Burdwan-713104, West Bengal, India. pabitracc@yahoo.com.
authors: Manjira
authors: M
authors: Mukherjee
authors: Siddhartha
authors: S
authors: Pal
authors: Somenath
authors: S
authors: Lohar
authors: Buddhadeb
authors: B
authors: Sen
authors: Supriti
authors: S
authors: Sen
authors: Samya
authors: S
authors: Banerjee
authors: Snehasis
authors: S
authors: Banerjee
authors: Pabitra
authors: P
authors: Chattopadhyay
mesh_terms: D000535:Aluminum / Q000737:chemistry*; D015415:Biomarkers / Q000032:analysis*; D002614:Chelating Agents / Q000737:chemistry; D002623:Chemistry Techniques, Analytical; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D018360:Crystallography, X-Ray; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D007477:Ions / Q000737:chemistry; D018613:Microscopy, Confocal; D008968:Molecular Conformation; D009284:Naphthols / Q000138:chemical synthesis / Q000737:chemistry*; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D014867:Water / Q000737:chemistry
chemical_list: C000600916:1-((5-phenyl-1H-pyrazole-3-ylimino)methyl)naphthalen-2-ol; D015415:Biomarkers; D002614:Chelating Agents; D056831:Coordination Complexes; D005456:Fluorescent Dyes; D007477:Ions; D009284:Naphthols; D011720:Pyrazoles; D014867:Water; C031280:pyrazole; D000535:Aluminum