title: [The comparison of short-term outcome between aqueous drainage pathway reconstruction surgery versus canaloplasty for open angle glaucoma].
abstract: OBJECTIVE
  To compare the safety and efficacy between canaloplasty and aqueous drainage pathway reconstruction surgery in patients with open-angle glaucoma (OAG).
  
  
  METHODS
  It is a retrospective case series study. Thirty-one eyes (25 patients) with OAG were divided into canaloplasty (n = 17; 54.8%) group or aqueous drainage pathway reconstruction (n = 14; 45.2%) group. The intraocular pressure (IOP), numbers of IOP-lowering medications and incidence of complications were recorded at 1 day, 1 week, 1, 3, 6 and 12 months after the operation. Independent-samples T test was used to compare the IOP, numbers of IOP-lowering medications before and 1, 3, 6, 12, 24 months after surgery between two groups. Kaplan-Meier Survival Analysis was used to analyze the success rate of these two surgical methods. Log rank test was used to compare the difference of cumulative success rate at 6, 12 months after surgery.
  
  
  RESULTS
  The mean IOP values were (24.7 ± 8.7) , (14.5 ± 2.5), (14.9 ± 2.5) , (14.9 ± 2.5), (14.7 ± 2.1) and (15.4 ± 2.3) mmHg (1 mmHg = 0.133 kPa) in canaloplasty group at before surgery, 1, 3, 6, 12 and 24 months after surgery. The same values were (28.5 ± 10.6), (14.3 ± 3.6), (14.2 ± 3.2), (14.3 ± 3.6), (15.9 ± 3.2) and (14.6 ± 0.7) mmHg in aqueous drainage pathway reconstruction group. There was no difference in the extent of IOP reduction between these two groups (preoperative: t = -1.1014, P = 0.278; postoperative 1 month: t = 0.696, P = 0.492;3 month: t = 0.594, P = 0.557; 6 month: t = 0.536, P = 0.596; 12 month: t = -1.127, P = 0.273; 24 month: t = 0.455, P = 0.656). There were significant differences (P < 0.01) in post-surgery IOP lowering medication usage between these two groups, while pre-surgery medication usage were similar. The incidence of hyphema was significantly lower in aqueous drainage pathway reconstruction surgery group (2 eyes) than that in canaloplasty group (11 eyes).
  
  
  CONCLUSIONS
  Both canaloplasty and aqueous drainage pathway reconstruction could reduce IOP effectively for open-angle glaucoma. The incidence of complication was lower in the aqueous drainage pathway reconstruction group than canaloplasty group. However, long-term efficacy between these two groups is yet to be determined.
authors: Beijing Tongren Eye Center,Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Science Key Lab, Beijing 100730, China. Email:wningli@vip.163.com.
authors: Ningli
authors: N
authors: Wang
authors: Beijing Tongren Eye Center,Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Science Key Lab, Beijing 100730, China.
authors: Huaizhou
authors: H
authors: Wang
authors: Beijing Tongren Eye Center,Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Science Key Lab, Beijing 100730, China.
authors: Jie
authors: J
authors: Hong
authors: Beijing Tongren Eye Center,Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Science Key Lab, Beijing 100730, China.
authors: Bowen
authors: B
authors: Zhao
authors: Beijing Tongren Eye Center,Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Science Key Lab, Beijing 100730, China.
authors: Yiwen
authors: Y
authors: Cao
authors: Beijing Tongren Eye Center,Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Science Key Lab, Beijing 100730, China.
authors: Jinghong
authors: J
authors: Sang
authors: Beijing Tongren Eye Center,Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Science Key Lab, Beijing 100730, China.
authors: Diya
authors: D
authors: Yang
mesh_terms: D000368:Aged; D001082:Aqueous Humor; D004322:Drainage / Q000379:methods; D018463:Filtering Surgery / Q000009:adverse effects / Q000379:methods*; D005902:Glaucoma, Open-Angle / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D053208:Kaplan-Meier Estimate; D012189:Retrospective Studies; D014065:Tonometry, Ocular; D016896:Treatment Outcome; D014792:Visual Acuity