title: Force and the spindle: mechanical cues in mitotic spindle orientation.
abstract: The mechanical environment of a cell has a profound effect on its behaviour, from dictating cell shape to driving the transcription of specific genes. Recent studies have demonstrated that mechanical forces play a key role in orienting the mitotic spindle, and therefore cell division, in both single cells and tissues. Whilst the molecular machinery that mediates the link between external force and the mitotic spindle remains largely unknown, it is becoming increasingly clear that this is a widely used mechanism which could prove vital for coordinating cell division orientation across tissues in a variety of contexts.
authors: Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom.
authors: Alexander
authors: A
authors: Nestor-Bergmann
authors: Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom.
authors: Georgina
authors: G
authors: Goddard
authors: Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom. Electronic address: sarah.woolner@manchester.ac.uk.
authors: Sarah
authors: S
authors: Woolner
mesh_terms: D000199:Actins / Q000502:physiology; D000818:Animals; D001696:Biomechanical Phenomena; D048430:Cell Shape; D006801:Humans; D008938:Mitosis; D009218:Myosins / Q000502:physiology; D021381:Protein Transport; D008941:Spindle Apparatus / Q000502:physiology*
chemical_list: D000199:Actins; D009218:Myosins