title: The heat shock protein-CD91 pathway mediates tumor immunosurveillance.
abstract: Tumor immunosurveillance can be readily observed in mice and humans. Here, we examine how T-cell responses are primed during tumorigenesis, a condition in which immunostimulatory antigens are extraordinarily scarce. We recently demonstrated that the HSP-CD91 pathway is indispensable for antigen cross-presentation, and thus immunosurveillance, in cancer.
authors: Department of Immunology; University of Pittsburgh; Pittsburgh, PA USA.
authors: Yu Jerry
authors: YJ
authors: Zhou
authors: Department of Immunology; University of Pittsburgh; Pittsburgh, PA USA.
authors: Robert Julian
authors: RJ
authors: Binder
keywords: CD91; HSP; T cells; cross-presentation; tumor