title: The role of CUX1 in antagonizing NF-κB signaling in TAMs.
abstract: Macrophages represent a major component of the tumor microenvironment and contribute to neoplasia initiation and cancer progression. However, the molecular mechanisms underlying these phenomena are only partially understood. Manipulating the transcriptional activity of the macrophage functional specification factor NF-κB by virtue of a novel regulatory factor cut-like homeobox 1 (CUX1) may provide a potential target for therapeutic intervention.
authors: Department of Gastroenterology, Endocrinology and Metabolism; Philipps-University Marburg; Marburg, Germany.
authors: Benjamin
authors: B
authors: Kühnemuth
authors: Department of Gastroenterology, Endocrinology and Metabolism; Philipps-University Marburg; Marburg, Germany.
authors: Patrick
authors: P
authors: Michl
keywords: CUX1; NF-kB; pancreatic cancer; stroma; tumor-associated macrophages