title: Novel supramolecular elastomer films based on linear carboxyl-terminated polydimethylsiloxane oligomers: preparation, characterization, biocompatibility, and application in wound dressings.
abstract: A novel supramolecular elastomer (SESi) based on multiple hydrogen bond associations between low-molecular-weight polydimethylsiloxane chains was obtained through a two-step reaction of linear carboxyl-terminated polydimethylsiloxane oligomers with diethylenetriamine and urea, and the reaction mechanism was characterized. The results of differential scanning calorimetry and X-ray diffraction analyses indicated that the supramolecular network structure is completely amorphous, endowing SESi with rubber-like elastic behavior at room temperature. The transparent SESi film prepared by hot pressing displayed nice viscoelasticity, benign water absorption, water vapor transition rates, and ideal biocompatibility; and did not show cytotoxicity or skin irritation. These properties allow the elastomer to function as an occlusive wound dressing. To demonstrate its potential in wound dressings, a detailed comparison of commercial 3M Tegaderm(™) film and the SESi film was conducted. The SESi film exhibited similar effects in wound healing, and the wound bed was covered by the SESi film without the occurrence of significant adverse reactions.
authors: a Department of Polymer Material Science and Engineering , College of Material Science and Engineering, South China University of Technology , 381 Wushan Road, Guangzhou 510641 , Guangdong , China.
authors: Anqiang
authors: A
authors: Zhang
authors: Wenwen
authors: W
authors: Deng
authors: Yaling
authors: Y
authors: Lin
authors: Junhui
authors: J
authors: Ye
authors: Yaomin
authors: Y
authors: Dong
authors: Yufeng
authors: Y
authors: Lei
authors: Hongtao
authors: H
authors: Chen
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D045744:Cell Line, Tumor; D004129:Dimethylpolysiloxanes / Q000138:chemical synthesis* / Q000737:chemistry*; D004548:Elasticity; D020724:Elastomers / Q000138:chemical synthesis* / Q000737:chemistry*; D005347:Fibroblasts / Q000502:physiology; D006860:Hydrogen Bonding; D008297:Male; D008422:Materials Testing; D051379:Mice; D009779:Occlusive Dressings; D011073:Polyamines / Q000737:chemistry; D011817:Rabbits; D017208:Rats, Wistar; D012879:Skin Physiological Phenomena; D014508:Urea / Q000737:chemistry; D055682:Viscoelastic Substances / Q000138:chemical synthesis / Q000737:chemistry; D014867:Water / Q000737:chemistry; D014945:Wound Healing; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D004129:Dimethylpolysiloxanes; D020724:Elastomers; D011073:Polyamines; D055682:Viscoelastic Substances; C005391:diethylenetriamine; D014867:Water; D014508:Urea
keywords: biocompatibility; cytotoxicity; multihydrogen bonds association; supramolecular elastomer based on polydimethylsiloxanes; wound dressing