title: Free radical scavenging activity and neuroprotective potentials of D138, one Cu(II)/Zn(II) Schiff-base complex derived from N,N'-bis(2-hydroxynaphthylmethylidene)-1,3-propanediamine.
abstract: There is increasing evidence that free radicals play an important role in neuronal damages induced by diabetes mellitus or cerebral ischemia insults. Antioxidants with free radical scavenging activities have been shown to be beneficial and neuroprotective for these pathological conditions. Here, we report free radical scavenging activity and neuroprotective potential of D138, one copper(II)/zinc(II) Schiff-base complex derived from N,N'-2(2-hydroxynaphthylmethylidene)-1,3-propanediamine. The data from three in vitro assays, 2,2-diphenyl-1-picrylhydrazyl assay, nitro blue tetrazolium assay and hydroxyl radical scavenging assay, indicated that D138 presented a potent free radical scavenging activity. The neuroprotective and antioxidative effects of D138 were further evaluated in vivo using bilateral common carotid artery occlusion (BCCAO) mouse model and streptozotocin (STZ) diabetic mouse model. Our results indicated that treatment of D138 significantly ameliorated the hippocampal neuronal damage and the oxidative stress levels in these animal models. Moreover, D138 also reversed the behavioral deficiencies induced by BCCAO or STZ, as assessed by Y-maze test and fear conditioning test. In conclusion, all these findings support that D138 exerts free radical scavenging and neuroprotective activities and has the potentials to be a potent therapeutic candidate for brain oxidative damage induced by cerebral ischemia or diabetes mellitus.
authors: Department of Pharmacy, School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, 116029, China.
authors: Che
authors: C
authors: Wang
authors: Zheng-Xu
authors: ZX
authors: Cai
authors: Zhong-Lu
authors: ZL
authors: You
authors: Hui-Shu
authors: HS
authors: Guo
authors: De-Jing
authors: DJ
authors: Shang
authors: Xiao-Ling
authors: XL
authors: Wang
authors: Liang
authors: L
authors: Zhang
authors: Li-Jie
authors: LJ
authors: Ma
authors: Jun
authors: J
authors: Tan
authors: Wei-Dong
authors: WD
authors: Le
authors: Song
authors: S
authors: Li
mesh_terms: D000818:Animals; D056831:Coordination Complexes / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000517:prevention & control; D016166:Free Radical Scavengers / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000494:pharmacology; D008297:Male; D051379:Mice; D018696:Neuroprotective Agents / Q000494:pharmacology*; D012545:Schiff Bases / Q000494:pharmacology*; D013311:Streptozocin
chemical_list: D056831:Coordination Complexes; C000603448:D138 compound; D016166:Free Radical Scavengers; D007004:Hypoglycemic Agents; D018696:Neuroprotective Agents; D012545:Schiff Bases; D013311:Streptozocin