title: Inherent insulin sensitivity is a major determinant of multimeric adiponectin responsiveness to short-term weight loss in extreme obesity.
abstract: High molecular weight (HMW-A) adiponectin levels mirror alterations in glucose homeostasis better than medium (MMW-A) and low molecular weight (LMW-A) components. In 25 patients with wide-range extreme obesity (BMI 40-77 kg/m(2)), we aimed to explore if improvements of multimeric adiponectin following 4-wk weight loss reflect baseline OGTT-derived insulin sensitivity (ISIOGTT) and disposition index (DIOGTT). Compared to 40 lean controls, adiponectin oligomers were lower in extreme obesity (p < 0.001) and, within this group, HMW-A levels were higher in insulin-sensitive (p < 0.05) than -resistant patients. In obese patients, short-term weight loss did not change total adiponectin levels and insulin resistance, while the distribution pattern of adiponectin oligomers changed due to significant increment of HMW-A (p < 0.01) and reduction of MMW-A (p < 0.05). By multivariate analysis, final HMW-A levels were significantly related to baseline ISIOGTT and final body weight (adjusted R(2) = 0.41). Our data suggest that HMW adiponectin may reflect baseline insulin sensitivity appropriately in the context of extreme obesity. Especially, we documented that HMW-A is promptly responsive to short-term weight loss prior to changes in insulin resistance, by a magnitude that is proportioned to whole body insulin sensitivity. This may suggest an insulin sensitivity-dependent control operated by HMW-A on metabolic dynamics of patients with extreme obesity.
authors: Laboratory of Metabolic Research, Ospedale S. Giuseppe, I.R.C.S.S. Istituto Auxologico Italiano, Strada Cadorna 90, 28921, Piancavallo-Verbania.
authors: Stefania
authors: S
authors: Mai
authors: Department of Health Sciences, Università del Piemonte Orientale "Amedeo Avogadro", Via Solaroli 17, 28100, Novara.
authors: Gillian E
authors: GE
authors: Walker
authors: Division of Rehabilitative Medicine, Ospedale S. Giuseppe, I.R.C.S.S. Istituto Auxologico Italiano, Strada Cadorna 90, 28921, Piancavallo-Verbania.
authors: Amelia
authors: A
authors: Brunani
authors: Division of General Medicine, Ospedale S. Giuseppe, I.R.C.S.S. Istituto Auxologico Italiano, Strada Cadorna 90, 28921, Piancavallo-Verbania.
authors: Gabriele
authors: G
authors: Guzzaloni
authors: Division of Internal Medicine (G.G.), Università del Piemonte Orientale "Amedeo Avogadro", Via Solaroli 17, 28100, Novara.
authors: Glenda
authors: G
authors: Grossi
authors: Division of Surgery, Università del Piemonte Orientale "Amedeo Avogadro", Via Solaroli 17, 28100, Novara.
authors: Alberto
authors: A
authors: Oldani
authors: Department of Translational Medicine, Università del Piemonte Orientale "Amedeo Avogadro", Via Solaroli 17, 28100, Novara.
authors: Gianluca
authors: G
authors: Aimaretti
authors: Division of General Medicine, Ospedale S. Giuseppe, I.R.C.S.S. Istituto Auxologico Italiano, Strada Cadorna 90, 28921, Piancavallo-Verbania.
authors: Massimo
authors: M
authors: Scacchi
authors: 1] Division of General Medicine, Ospedale S. Giuseppe, I.R.C.S.S. Istituto Auxologico Italiano, Strada Cadorna 90, 28921, Piancavallo-Verbania [2] Department of Translational Medicine, Università del Piemonte Orientale "Amedeo Avogadro", Via Solaroli 17, 28100, Novara.
authors: Paolo
authors: P
authors: Marzullo
mesh_terms: D052242:Adiponectin / Q000097:blood* / Q000737:chemistry; D000328:Adult; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D005260:Female; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood* / Q000178:diet therapy; D020836:Protein Structure, Quaternary; D015431:Weight Loss
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D007328:Insulin