title: Synthesis, structure and antimicrobial evaluation of new 3,3a,4,5-tetrahydro-2H-benzo[g]indazol-2-yl-thiazol-4(5H)-ones.
abstract: The reaction of semicarbazide or thiosemicarbazide with 2-arylidene-1-tetralones under alkaline condition affords 3,3a,4,5-tetrahydro-2H-benzo[g]indazole-2-carbo(thio)amides as a mixture of cis and trans diastereoisomers of 3-H and 3a-H. The synthesis of new indazolyl-thiazol-4(5H)-ones from the condensation of cis isomer and α-halo acids is reported. A DFT study along with X-ray single crystal data of a representative compound is presented. All the eight newly synthesised indazolyl-thiazol-4(5H)-ones were screened for their antibacterial and antifungal activities and some compounds have shown promising activities.
authors: Department of Chemistry, Sant Longowal Institute of Engineering & Technology, Longowal, Sangrur, Punjab 148106, India.
authors: Deepika
authors: D
authors: Gautam
authors: Department of Chemistry, Sant Longowal Institute of Engineering & Technology, Longowal, Sangrur, Punjab 148106, India. Electronic address: rpchaudhary65@gmail.com.
authors: R P
authors: RP
authors: Chaudhary
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D018360:Crystallography, X-Ray; D005658:Fungi / Q000187:drug effects; D007191:Indazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007536:Isomerism; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D066244:Proton Magnetic Resonance Spectroscopy
chemical_list: D000890:Anti-Infective Agents; D007191:Indazoles
keywords: 2-Arylidene-1-tetralone; Antimicrobial activities; DFT; Indazol-2-carbothioamides; Indazolyl-thiazol-4(5H)-one; X-ray diffraction