title: P-selectin: an unpredicted factor for deep vein thrombosis after total hip arthroplasty.
abstract: BACKGROUND
  Deep vein thrombosis (DVT) is a severe complication after total hip arthroplasty (THA). It leads to acute pulmonary embolism, a life-threatening disease. P-selectin is a 140-kDa transmembrane glycoprotein. Elevated P-selectin was associated with 1.7-fold increase in the risk of venous thrombosis.
  
  
  METHODS
  To confirm the association, a total of 91 subjects who received primary total hip arthroplasty using lateral approach performed by one skilled orthopedic surgeon were studied. All the patients were consecutively enrolled at the Center of Diagnosis and Treatment for Joint Diseases, Drum Tower Hospital affiliated to the Medical School of Nanjing University from 2010 to 2012. All the subjects received venography 3-5 days after operation. We measured P-selectin by means of a highly sensitive sandwich ELISA technique and a commercially available test reagent set.
  
  
  RESULTS
  No significant association was detected between P-selectin and DVT (all P values > 0.05). ΔsP-selectin was correlated with weight, APTT after operation, history of DVT, and diagnosis of primary disease ( P values were 0.03, 0.03, 0.04, and 0.02, resp.).
  
  
  CONCLUSIONS
  P-selectin may not be a predicted factor for deep vein thrombosis after total hip arthroplasty.
authors: The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu 210008, China ; Laboratory for Bone and Joint Diseases, Australian-China Joint Centre, Model Animal Research Center, Nanjing University, Nanjing, Jiangsu 210008, China.
authors: Dongquan
authors: D
authors: Shi
authors: The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu 210008, China ; Laboratory for Bone and Joint Diseases, Australian-China Joint Centre, Model Animal Research Center, Nanjing University, Nanjing, Jiangsu 210008, China.
authors: Xingquan
authors: X
authors: Xu
authors: The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu 210008, China.
authors: Zhihong
authors: Z
authors: Xu
authors: Laboratory for Mathematics, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan ; Laboratory for Statistical Analysis, Center for Genomic Medicine, RIKEN, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
authors: Takahiro
authors: T
authors: Nakamura
authors: The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu 210008, China.
authors: Yong
authors: Y
authors: Pang
authors: The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu 210008, China.
authors: Chen
authors: C
authors: Yao
authors: The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu 210008, China.
authors: Feng
authors: F
authors: Wang
authors: The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu 210008, China.
authors: Dongyang
authors: D
authors: Chen
authors: The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu 210008, China ; Laboratory for Bone and Joint Diseases, Australian-China Joint Centre, Model Animal Research Center, Nanjing University, Nanjing, Jiangsu 210008, China.
authors: Jin
authors: J
authors: Dai
authors: The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu 210008, China ; Laboratory for Bone and Joint Diseases, Australian-China Joint Centre, Model Animal Research Center, Nanjing University, Nanjing, Jiangsu 210008, China.
authors: Qing
authors: Q
authors: Jiang
mesh_terms: D000368:Aged; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009985:Orthopedics; D019007:P-Selectin / Q000097:blood*; D011183:Postoperative Complications; D012307:Risk Factors; D020246:Venous Thrombosis / Q000097:blood* / Q000175:diagnosis*
chemical_list: D019007:P-Selectin