title: Ectopic Cushing and other paraneoplastic syndromes in thoracic neuroendocrine tumors.
abstract: Overproduction of corticotropin by the pituitary gland or extrapituitary tumors leads to hypercortisolism or Cushing syndrome. Diagnosis of suspected Cushing syndrome involves 3 major steps: confirmation of hypercortisolism, differentiation between corticotropin-independent and corticotropin-dependent causes of Cushing syndrome, and distinction between pituitary and ectopic corticotropin production. A definitive diagnosis of ectopic corticotropin secretion requires stringent criteria, including reversal of the clinical picture after resection of the tumor and/or demonstration of corticotropin immunohistochemical staining within the tumor tissue.
authors: Endocrinology Unit, Department of Internal Medicine and Medical Specialties, Center of Excellence for Biomedical Research, IRCCS AOU San Martino-IST, University of Genoa, viale Benedetto XV, Genoa 16132, Italy. Electronic address: ferone@unige.it.
authors: Diego
authors: D
authors: Ferone
authors: Endocrinology Unit, Department of Internal Medicine and Medical Specialties, Center of Excellence for Biomedical Research, IRCCS AOU San Martino-IST, University of Genoa, viale Benedetto XV, Genoa 16132, Italy.
authors: Manuela
authors: M
authors: Albertelli
mesh_terms: D000182:ACTH Syndrome, Ectopic / Q000209:etiology*; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D003480:Cushing Syndrome / Q000209:etiology*; D006801:Humans; D018358:Neuroendocrine Tumors / Q000150:complications* / Q000601:surgery; D010257:Paraneoplastic Syndromes; D013899:Thoracic Neoplasms / Q000150:complications* / Q000601:surgery
chemical_list: D000324:Adrenocorticotropic Hormone
keywords: Corticotropin; Cortisol; Cushing; Neuroendocrine tumors; Paraneoplastic syndrome