title: Hydroxysafflor yellow a attenuates small airway remodeling in a rat model of chronic obstructive pulmonary disease.
abstract: Our previous studies found that hydroxysafflor yellow A (HSYA), an active ingredient in Carthamus tinctorius L., has anti-inflammatory and anti-fibrosis properties. In this study, we investigated the effect of HSYA on small airway remodeling (SAR) in a chronic obstructive pulmonary disease (COPD) rat model induced by cigarette smoke and lipopolysaccharide (LPS). SAR is a common lesion in COPD characterized by thickening of the airway wall, mainly by subepithelial fibrosis. In this study the thickness of the small airway was determined by total wall area/basement membrane perimeter (WAt/Pbm). Collagen deposition of the small airway was assessed by Masson's trichrome staining. HSYA significantly attenuated the thickening and collagen deposition of the small airway and inhibited transforming growth factor β1 (TGF-β1) mRNA and protein expression in COPD rat. In addition, HSYA inhibited the phosphorylation of p38 mitogen-activated protein kinases (MAPK) in the lung tissue of rat. HSYA can attenuate experimentally induced airway remodeling and this attenuation may be attributed to suppression of TGF-β1 expression.
authors: Department of Pharmacology, Beijing Institute of Heart Lung and Blood Vessel Diseases-Beijing An Zhen Hospital, Capital Medical University.
authors: Yu
authors: Y
authors: Wang
authors: Changjiang
authors: C
authors: Xue
authors: Fang
authors: F
authors: Dong
authors: Yuanyuan
authors: Y
authors: Peng
authors: Yadan
authors: Y
authors: Zhang
authors: Ming
authors: M
authors: Jin
authors: Baoxia
authors: B
authors: Zang
authors: Li
authors: L
authors: Tan
mesh_terms: D056151:Airway Remodeling / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D002599:Chalcone / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D004195:Disease Models, Animal; D008297:Male; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy* / Q000473:pathology; D011809:Quinones / Q000494:pharmacology* / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D011809:Quinones; C085278:hydroxysafflor yellow A; D002599:Chalcone