title: Impact of renal function and protein intake on blood urea nitrogen in preterm infants in the first 3 weeks of life.
abstract: OBJECTIVE
  To examine the relationship between blood urea nitrogen (BUN) during the first 3 weeks of life and protein intake and creatinine (Cr) and to quantify the effect of protein intake on postnatal growth in preterm infants.
  
  
  METHODS
  This is a 4-year, single-center, retrospective cohort study. We used multivariable linear regression models to examine the relationships between mean weekly BUN and protein intake adjusted for mean weekly Cr and potential confounders. We used additional regression models to examine the effect of protein intake on growth during this period.
  
  
  RESULTS
  Overall, 249 infants met study criteria. As protein intake increased over the first 3 weeks of life, both BUN and Cr decreased significantly. Linear regression models showed protein intake and Cr were each significantly associated with mean BUN for each study week.
  
  
  CONCLUSIONS
  Protein intake and Cr were each significantly associated with BUN. Significant amelioration of growth failure was seen with higher protein intake.
authors: 1] Mount Sinai Medical Center, Division of Newborn Medicine, Department of Pediatrics, Kravis Children's Hospital, New York, NY, USA [2] Department of Pediatrics, The Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors: A S
authors: AS
authors: Weintraub
authors: Department of Pediatrics, The Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors: V
authors: V
authors: Blanco
authors: Department of Pediatrics, The Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors: M
authors: M
authors: Barnes
authors: 1] Mount Sinai Medical Center, Division of Newborn Medicine, Department of Pediatrics, Kravis Children's Hospital, New York, NY, USA [2] Department of Pediatrics, The Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors: R S
authors: RS
authors: Green
mesh_terms: D001806:Blood Urea Nitrogen; D015331:Cohort Studies; D003404:Creatinine / Q000097:blood; D004044:Dietary Proteins / Q000008:administration & dosage*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood* / Q000254:growth & development; D016014:Linear Models; D012189:Retrospective Studies
chemical_list: D004044:Dietary Proteins; D003404:Creatinine