title: Enantio-separation of drugs with multiple chiral centers by chromatography and capillary electrophoresis.
abstract: Some drugs with more than one chiral center are of high medicinal values. However, the chiral resolution of such types of racemate is a challenging task for scientists. The evolution of efficient chiral selectors is a hope for the future. Some papers have described such types of chiral resolution. The different techniques used for the purpose are HPLC, micellar electrokinetic chromatography, supercritical fluid chromatography, capillary electrochromatography and capillary electrophoresis. Owing to these facts, it was necessary to review the enantiomeric resolution of racemic drugs having more than one chiral center. The present article describes the chiral resolution of labetalol, formoterol, nadolol, indenolol, nebivolol and diltiazem using above cited techniques. In addition, attempts have been made to discuss the chiral recognition mechanism and future perspectives.
authors: Department of Chemistry, College of Science, King Saud University, Riyadh, 11451, Kingdom of Saudi Arabia.
authors: Zeid A
authors: ZA
authors: Al-Othman
authors: Abdulrahman
authors: A
authors: Al-Warthan
authors: Syed Dilshad
authors: SD
authors: Alam
authors: Imran
authors: I
authors: Ali
mesh_terms: D020374:Chromatography, Micellar Electrokinetic Capillary; D019075:Electrophoresis, Capillary; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000302:isolation & purification; D013237:Stereoisomerism
chemical_list: D004364:Pharmaceutical Preparations
keywords: chiral recognition mechanism; chiral resolution; chiral selectors; future perspectives; multiple chiral center racemates