title: Polyphenol isolated from Corni Fructus, 7-O-galloyl-D-sedoheptulose, modulates advanced glycation endproduct-related pathway in type 2 diabetic db/db mice.
abstract: 7-O-Galloyl-D-sedoheptulose (GS) is the bioactive polyphenol isolated from the low-molecular-weight fraction of Corni Fructus (Cornus officinalis Sieb. et Zucc.). The present study was conducted to examine whether GS has an ameliorative effect on the liver of type 2 diabetic db/db mice. GS (20 or 100 mg/kg body weight/day, per os) was administered every day for 6 weeks to db/db mice, and its effect was compared with vehicle-treated db/db and m/m mice. The administration of GS decreased the elevated serum glucose, leptin, insulin, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), resistin, and hepatic functional parameters, and reduced the increased fluorescent advanced glycation endproducts (AGEs) and reactive oxygen species in the liver. The db/db mice exhibited the up-regulation of receptor for AGEs (RAGE) and AGE-related proteins; however, GS treatment significantly reduced those expressions. Moreover, the augmented expressions of oxidative stress- and inflammation-related proteins, phospho-extracellular-signal regulated kinase 1/2, phospho-c-Jun N-terminal kinase, nuclear factor-kappa B, activator protein-1, monocyte chemotactic protein-1, intracellular adhesion molecule-1, TNF-α, and IL-6, were down-regulated by GS administration. Hematoxylin-eosin staining showed that the increased hepatocellular damage in the liver of db/db mice improved with GS administration. The present results support the evidence for GS ameliorating hepatic damage through the RAGE-mediated inflammation pathway.
authors: College of Korean Medicine, Daegu Haany University, Daegu, 706-060, Korea.
authors: Chan Hum
authors: CH
authors: Park
authors: Jeong Sook
authors: JS
authors: Noh
authors: Takashi
authors: T
authors: Tanaka
authors: Seong-Soo
authors: SS
authors: Roh
authors: Jang Cheon
authors: JC
authors: Lee
authors: Takako
authors: T
authors: Yokozawa
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D001835:Body Weight / Q000187:drug effects; D029768:Cornus / Q000737:chemistry*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D017127:Glycation End Products, Advanced / Q000187:drug effects / Q000378:metabolism*; D006539:Heptoses / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D059808:Polyphenols / Q000302:isolation & purification / Q000494:pharmacology*; D000067759:Receptor for Advanced Glycation End Products / Q000378:metabolism
chemical_list: C540464:7-O-galloyl-D-sedoheptulose; C000593873:Ager protein, mouse; D015415:Biomarkers; D017127:Glycation End Products, Advanced; D006539:Heptoses; D059808:Polyphenols; D000067759:Receptor for Advanced Glycation End Products