title: Combinations of immunostimulatory antibodies with synergistic effects against spontaneous cancer.
abstract: Immunostimulatory monoclonal antibodies can be given in combinations, hence modulating the activity of 2 or more receptors of the immune system. Some of these combinations have been shown to synergize at the elicitation of therapeutically relevant immune responses in transgenic mice developing spontaneous, oncogene-driven tumors, including multifocal hepatocellular carcinomas expressing ovalbumin as a surrogate tumor-associated antigen.
authors: Departamento de Inmunología; Centro de Investigación Médica Aplicada (CIMA); Universidad de Navarra; Pamplona, Spain.
authors: Aizea
authors: A
authors: Morales-Kastresana
authors: Departamento de Inmunología; Centro de Investigación Médica Aplicada (CIMA); Universidad de Navarra; Pamplona, Spain.
authors: Sara
authors: S
authors: Labiano
authors: Department of Pathology; University of Bonn; Bonn, Germany.
authors: Ines
authors: I
authors: Gütgemann
authors: Departamento de Inmunología; Centro de Investigación Médica Aplicada (CIMA); Universidad de Navarra; Pamplona, Spain ; Departamento de Oncología; Clínica Universidad de Navarra; Pamplona, Spain.
authors: Ignacio
authors: I
authors: Melero
keywords: B7-H1 (PD-L1); CD137 (4-1BB); OX40 (CD134); T lymphocytes; immunotherapy