title: Lapatinib and platinum-based chemotherapy ameliorate breast cancer with choroidal metastasis and restore visual acuity.
abstract: Involvement of the central nervous system in metastatic breast cancer is a particularly dismal occurrence because of its effects on mortality and quality of life. Development of choroidal metastasis in a breast cancer patient indicates poor prognosis and has become the major life-limiting problem. Various treatment modalities for choroidal metastasis have been applied with different efficacy. Here we describe a patient with HER2-overexpressing breast cancer and limited choroidal metastasis who responded to an HER2 tyrosine kinase inhibitor after failure of radiotherapy and chemotherapy. Her visual acuity was completely and durably restored after the targeted therapy. This case provides a unique treatment experience of breast cancer with choroidal metastasis.
authors: Uei-Han
authors: UH
authors: Ju
authors: Ming-Ling
authors: ML
authors: Tsai
authors: Chun-Shu
authors: CS
authors: Lin
authors: Tsu-Yi
authors: TY
authors: Chao
authors: Ming-Shen
authors: MS
authors: Dai
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology / Q000556:secondary*; D017024:Chemotherapy, Adjuvant; D002830:Choroid Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology / Q000556:secondary*; D005260:Female; D006801:Humans; D000077341:Lapatinib; D015411:Mastectomy, Modified Radical; D008875:Middle Aged; D058990:Molecular Targeted Therapy / Q000379:methods; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D017671:Platinum Compounds / Q000008:administration & dosage; D011799:Quinazolines / Q000008:administration & dosage; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*; D016896:Treatment Outcome; D014792:Visual Acuity / Q000187:drug effects*
chemical_list: D014408:Biomarkers, Tumor; D000077341:Lapatinib; D017671:Platinum Compounds; D011799:Quinazolines; D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human