title: Dissecting the role of bone marrow stromal cells on bone metastases.
abstract: Tumor-induced bone disease is a dynamic process that involves interactions with many cell types. Once metastatic cancer cells reach the bone, they are in contact with many different cell types that are present in the cell-rich bone marrow. These cells include the immune cells, myeloid cells, fibroblasts, osteoblasts, osteoclasts, and mesenchymal stem cells. Each of these cell populations can influence the behavior or gene expression of both the tumor cells and the bone microenvironment. Additionally, the tumor itself can alter the behavior of these bone marrow cells which further alters both the microenvironment and the tumor cells. While many groups focus on studying these interactions, much remains unknown. A better understanding of the interactions between the tumor cells and the bone microenvironment will improve our knowledge on how tumors establish in bone and may lead to improvements in diagnosing and treating bone metastases. This review details our current knowledge on the interactions between tumor cells that reside in bone and their microenvironment.
authors: Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN 37212, USA ; Center for Bone Biology, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, 2215B Garland Avenue, 1235 MRBIV, Nashville, TN 37232, USA.
authors: Denise
authors: D
authors: Buenrostro
authors: Center for Bone Biology, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, 2215B Garland Avenue, 1235 MRBIV, Nashville, TN 37232, USA ; Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA.
authors: Serk In
authors: SI
authors: Park
authors: Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN 37212, USA ; Center for Bone Biology, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, 2215B Garland Avenue, 1235 MRBIV, Nashville, TN 37232, USA ; Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA.
authors: Julie A
authors: JA
authors: Sterling
mesh_terms: D001859:Bone Neoplasms / Q000473:pathology* / Q000556:secondary*; D001842:Bone and Bones / Q000473:pathology; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D007107:Immune System; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000473:pathology; D010006:Osteoblasts / Q000166:cytology; D010010:Osteoclasts / Q000166:cytology; D059016:Tumor Microenvironment