title: [Molecular mechanisms of bone cancer pain].
abstract: Bone pain is one of the most frequent complications of bone metastasis, leading to a marked reduction in the quality of life of patients. The mechanisms of bone cancer pain are highly complicated ; however, noxious stimuli produced by cancer tissues and cancer-induced nerve injury are considered to be the major causes. Recent studies also suggest the possible involvement of acidic microenvironments created by cancer tissues and osteoclasts in cancer-induced bone pain. Understanding the molecular events may lead to the design of novel mechanism-based approaches for the management of bone pain associated with cancer metastasis.
authors: Department of Histology and Cell Biology, School of Dentistry, Matsumoto Dental University, Japan.
authors: Toru
authors: T
authors: Hiraga
mesh_terms: D001859:Bone Neoplasms / Q000378:metabolism / Q000556:secondary* / Q000628:therapy*; D006801:Humans; D058990:Molecular Targeted Therapy; D009361:Neoplasm Invasiveness; D010010:Osteoclasts / Q000378:metabolism; D010146:Pain / Q000209:etiology*; D059408:Pain Management