title: Chronic dietary supplementation of 4% figs on the modification of oxidative stress in Alzheimer's disease transgenic mouse model.
abstract: We assessed the changes in the plasma Aβ, oxidative stress/antioxidants, and membrane bound enzymes in the cerebral cortex and hippocampus of Alzheimer's disease (AD) transgenic mice (Tg2576) after dietary supplementation of Omani figs fruits for 15 months along with spatial memory and learning test. AD Tg mice on control diet without figs showed significant impairment in spatial learning ability compared to the wild-type mice on same diet and figs fed Tg mice as well. Significant increase in oxidative stress and reduced antioxidant status were observed in AD Tg mice. 4% figs treated AD Tg mice significantly attenuated oxidative damage, as evident by decreased lipid peroxidation and protein carbonyls and restoration of antioxidant status. Altered activities of membrane bound enzymes (Na(+) K(+) ATPase and acetylcholinesterase (AChE)) in AD Tg mice brain regions and was restored by figs treatment. Further, figs supplementation might be able to decrease the plasma levels of Aβ (1-40, 1-42) significantly in Tg mice suggesting a putative delay in the formation of plaques, which might be due to the presence of high natural antioxidants in figs. But this study warrants further extensive investigation to find a novel lead for a therapeutic target for AD from figs.
authors: Department of Food Science and Nutrition, College of Agriculture and Marine Sciences, P.O. Box 34, Sultan Qaboos University, Al-Khoud, 123 Muscat, Oman ; Ageing and Dementia Research Group, Sultan Qaboos University, 123 Muscat, Oman.
authors: Selvaraju
authors: 0000-0003-1691-1581
authors: S
authors: Subash
authors: Department of Food Science and Nutrition, College of Agriculture and Marine Sciences, P.O. Box 34, Sultan Qaboos University, Al-Khoud, 123 Muscat, Oman ; Ageing and Dementia Research Group, Sultan Qaboos University, 123 Muscat, Oman.
authors: Musthafa Mohamed
authors: MM
authors: Essa
authors: Ageing and Dementia Research Group, Sultan Qaboos University, 123 Muscat, Oman ; College of Medicine and Health Sciences, Sultan Qaboos University, 123 Muscat, Oman.
authors: Abdullah
authors: A
authors: Al-Asmi
authors: Ageing and Dementia Research Group, Sultan Qaboos University, 123 Muscat, Oman ; College of Medicine and Health Sciences, Sultan Qaboos University, 123 Muscat, Oman.
authors: Samir
authors: 0000-0002-9858-5582
authors: S
authors: Al-Adawi
authors: Ageing and Dementia Research Group, Sultan Qaboos University, 123 Muscat, Oman ; Oman Assistant Pharmacy Institute, Directorate General of Education and Training, Ministry of Health, P.O. Box 1928, 114 Muttrah, Oman.
authors: Ragini
authors: R
authors: Vaishnav
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000544:Alzheimer Disease / Q000097:blood / Q000473:pathology* / Q000503:physiopathology; D016229:Amyloid beta-Peptides / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D002462:Cell Membrane / Q000201:enzymology; D002540:Cerebral Cortex / Q000201:enzymology / Q000473:pathology / Q000503:physiopathology; D019587:Dietary Supplements; D004195:Disease Models, Animal; D005260:Female; D030681:Ficus / Q000737:chemistry*; D006624:Hippocampus / Q000201:enzymology / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D015227:Lipid Peroxidation; D008822:Mice, Transgenic; D018384:Oxidative Stress; D050050:Protein Carbonylation; D065852:Spatial Memory; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D000975:Antioxidants; D002374:Catalase; D013482:Superoxide Dismutase; D000110:Acetylcholinesterase