title: Clinical and histological findings associated with autoantibodies detected by RNA immunoprecipitation in inflammatory myopathies.
abstract: Of 207 adult patients with idiopathic inflammatory myopathies, detection of autoantibodies by RNA immunoprecipitation showed that 99 patients (48%) were antibody-positive. We divided these 99 into five subgroups: anti-signal recognition particle (SRP), anti-aminoacyl transfer RNA synthetase, anti-Ku, anti-U1RNP, and anti-SSA/B. Younger age at onset, severe weakness, muscle atrophy, elevated creatine kinase, and necrosis in muscle fibers without inflammatory cell infiltration were found significantly more frequently among the patients with anti-SRP antibodies (n=41) compared to the antibody-negative patients (n=108). Autoantibody detection by RNA immunoprecipitation can provide useful information associated with clinical and histological findings.
authors: Department of Neurology, Keio University School of Medicine, Tokyo, Japan. Electronic address: sgsuzuki@z3.keio.jp.
authors: Shigeaki
authors: S
authors: Suzuki
authors: Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan; Department of Clinical Development, Translational Medical Center, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors: Takahiro
authors: T
authors: Yonekawa
authors: Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
authors: Masataka
authors: M
authors: Kuwana
authors: Department of Neurophysiology, Tokyo Medical University, Tokyo, Japan.
authors: Yukiko K
authors: YK
authors: Hayashi
authors: Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
authors: Yuka
authors: Y
authors: Okazaki
authors: Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan.
authors: Yasushi
authors: Y
authors: Kawaguchi
authors: Department of Neurology, Keio University School of Medicine, Tokyo, Japan.
authors: Norihiro
authors: N
authors: Suzuki
authors: Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan; Department of Clinical Development, Translational Medical Center, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors: Ichizo
authors: I
authors: Nishino
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000276:immunology*; D047369:Chromatin Immunoprecipitation / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009133:Muscular Atrophy / Q000276:immunology / Q000473:pathology; D009188:Myelitis, Transverse / Q000276:immunology* / Q000473:pathology; D009220:Myositis / Q000276:immunology* / Q000473:pathology; D012313:RNA; D018271:Signal Recognition Particle / Q000276:immunology
chemical_list: D001323:Autoantibodies; D018271:Signal Recognition Particle; D012313:RNA
keywords: Autoantibodies; Inflammatory myopathies; Muscle biopsy; Necrotizing myopathy; RNA immunoprecipitation; Signal recognition particle