title: A four-year surveillance program for detection of Plasmodium falciparum chloroquine resistance in Honduras.
abstract: Countries could use the monitoring of drug resistance in malaria parasites as an effective early warning system to develop the timely response mechanisms that are required to avert the further spread of malaria. Drug resistance surveillance is essential in areas where no drug resistance has been reported, especially if neighbouring countries have previously reported resistance. Here, we present the results of a four-year surveillance program based on the sequencing of the pfcrt gene of Plasmodium falciparum populations from endemic areas of Honduras. All isolates were susceptible to chloroquine, as revealed by the pfcrt "CVMNK" genotype in codons 72-76.
authors: Microbiology Research Institute, National Autonomous University of Honduras, Tegucigalpa, Honduras.
authors: Gustavo A
authors: GA
authors: Fontecha
authors: Department of Health Sciences, Faculty of Applied Health Sciences, Brock University, Saint Catharines, ON, Canada.
authors: Ana L
authors: AL
authors: Sanchez
authors: National Malaria Laboratory, National Department of Surveillance, Ministry of Health-Honduras, Tegucigalpa, Honduras.
authors: Meisy
authors: M
authors: Mendoza
authors: National Malaria Program, Department of Health Promotion, Ministry of Health-Honduras, Tegucigalpa, Honduras.
authors: Engels
authors: E
authors: Banegas
authors: Panamerican Health Organization-Honduras, Tegucigalpa, Honduras.
authors: Rosa E
authors: RE
authors: Mejía-Torres
mesh_terms: D000962:Antimalarials / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology*; D016054:DNA, Protozoan / Q000235:genetics; D004351:Drug Resistance / Q000235:genetics*; D005838:Genotype; D006721:Honduras; D006801:Humans; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D011159:Population Surveillance; D015800:Protozoan Proteins / Q000235:genetics
chemical_list: D000962:Antimalarials; D016054:DNA, Protozoan; D015800:Protozoan Proteins; D002738:Chloroquine