title: Effect of DA-9701 on colorectal distension-induced visceral hypersensitivity in a rat model.
abstract: OBJECTIVE
  DA-9701 is a newly developed drug made from the vegetal extracts of Pharbitidis semen and Co-rydalis tuber. The aim of this study was to evaluate the effect of DA-9701 on colorectal distension (CRD)-induced visceral hypersensitivity in a rat model.
  
  
  METHODS
  Male Sprague-Dawley rats were subjected to neonatal colon irritation (CI) using CRD at 1 week after birth (CI group). At 6 weeks after birth, CRD was applied to these rats with a pressure of 20 to 90 mm Hg, and changes in the mean arterial pressure (MAP) were measured at baseline (i.e., without any drug administration) and after the administration of different doses of DA-9701.
  
  
  RESULTS
  In the absence of DA-9701, the MAP changes after CRD were significantly higher in the CI group than in the control group at all applied pressures. In the control group, MAP changes after CRD were not significantly affected by the administration of DA-9701. In the CI group, however, the administration of DA-9701 resulted in a significant decrease in MAP changes after CRD. The administration of DA-9701 at a dose of 1.0 mg/kg produced a more significant decrease in MAP changes than the 0.3 mg/kg dose.
  
  
  CONCLUSIONS
  The administration of DA-9701 resulted in a significant increase in pain threshold in rats with CRD-induced visceral hypersensitivity.
authors: Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors: Eun Ran
authors: ER
authors: Kim
authors: Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors: Byung-Hoon
authors: BH
authors: Min
authors: Dong-A ST, Co., Ltd., Research Center, Yongin, Korea.
authors: Tae Ho
authors: TH
authors: Lee
authors: Dong-A ST, Co., Ltd., Research Center, Yongin, Korea.
authors: Miwon
authors: M
authors: Son
authors: Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors: Poong-Lyul
authors: PL
authors: Rhee
mesh_terms: D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D062186:Arterial Pressure / Q000187:drug effects; D044683:Colon, Descending / Q000502:physiology; D004106:Dilatation / Q000379:methods; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D017288:Pain Threshold / Q000187:drug effects; D028321:Plant Preparations / Q000008:administration & dosage / Q000494:pharmacology*; D017207:Rats, Sprague-Dawley; D059265:Visceral Pain / Q000503:physiopathology / Q000517:prevention & control*
chemical_list: D000700:Analgesics; C533973:DA-9701; D005765:Gastrointestinal Agents; D028321:Plant Preparations
keywords: Colorectal distension; DA-9701; Gastrointestinal diseases; Visceral hypersensitivity