title: Baicalin reverse AMPA receptor expression and neuron apoptosis in chronic unpredictable mild stress rats.
abstract: Changes of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor expression could impacts the viability of neurons and brain levels of brain-derived neurotrophic factor (BDNF) expression in the key brain structures in the pathophysiology of depressive disorder. In the present study, chronic unpredictable mild stress (CUMS) degraded performance decreased AMPA receptor expression and increased neuron apoptosis. Treatment with baicalin (20, 40mg/kg) significantly reversed these changes. This study demonstrates that baicalin has potent antidepressant effect, likely through up-regulated the expression of AMPA receptor and suppression neuron apoptosis in CUMS-treated rats.
authors: Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing 210009, PR China.
authors: Hai-Yang
authors: HY
authors: Yu
authors: Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing 210009, PR China.
authors: Zhu-Jun
authors: ZJ
authors: Yin
authors: Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing 210009, PR China.
authors: Shui-Jin
authors: SJ
authors: Yang
authors: Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address: spma@cpu.edu.com.
authors: Shi-Ping
authors: SP
authors: Ma
mesh_terms: D059445:Anhedonia / Q000187:drug effects; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D019208:Brain-Derived Neurotrophic Factor / Q000096:biosynthesis; D053148:Caspase 3 / Q000096:biosynthesis; D005419:Flavonoids / Q000494:pharmacology*; D008297:Male; D009474:Neurons / Q000473:pathology; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D018091:Receptors, AMPA / Q000096:biosynthesis* / Q000235:genetics; D013315:Stress, Psychological / Q000503:physiopathology
chemical_list: D000928:Antidepressive Agents; D019208:Brain-Derived Neurotrophic Factor; D005419:Flavonoids; D012333:RNA, Messenger; D018091:Receptors, AMPA; C038044:baicalin; D053148:Caspase 3; C104722:glutamate receptor ionotropic, AMPA 2
keywords: Antidepressant; Baicalin; Bax; Bcl-2; Caspase-3; GluR2 subunit