title: The effect of hydroalcoholic extract of Coriandrum sativum on rat appetite.
abstract: OBJECTIVE
  Losing weight in consequence of appetite loss can be a sign of a serious underlying condition. Currently, the most widely prescribed medication for anorexia is cyproheptadine hydrochloride. However, the clinical use of cyproheptadine hydrochloride is limited by its side effects. In Iranian traditional medicine, Coriandrum sativum stimulates the appetite. Therefore, the effect of Coriandrum sativum (coriander) hydroalcoholic extract was investigated on food intake in rats.
  
  
  METHODS
  Thirty male Wistar rats were randomly divided into five groups. Two control groups were used, one group received 0.5 ml water per day (vehicle group), and another group did not receive anything (control group). The other 3 groups were daily treated by 50, 100 or 150 mg/kg of coriander for 7 days, respectively. The daily amount of the food eaten by each rat was measured for 10 days. The amount of energy intake of each rat was also calculated for 7 days during the intervention. The difference in energy intake was calculated and compared between groups.
  
  
  RESULTS
  There was no significant change in energy intake between control and vehicle groups. The change in energy intake after treatment by 100 and 150 mg/kg of the extract was significantly higher than other groups (p=0.030 and p=0.007) CONCLUSION: This study indicated that coriander had positive effects on appetite of rats. Future studies are needed to evaluate the mechanisms of the effects of this plant on appetite.
authors: Department of Nutrition, Biochemistry of Nutrition, Endoscopic & Minimally Invasive Surgery, and Cancer Research Centers, School of Medicine, Mashhad University of Medical Sciences, Mashhad , I. R. Iran.
authors: Mohsen
authors: M
authors: Nematy
authors: Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran.
authors: Maryam
authors: M
authors: Kamgar
authors: Medical Student, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran.
authors: Seyed Mohammad Reza
authors: SM
authors: Mohajeri
authors: Medical Student, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran.
authors: Seyed Amir
authors: SA
authors: Tabatabaei Zadeh
authors: Medical Student, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran.
authors: Mohammad Reza
authors: MR
authors: Jomezadeh
authors: Medical Student, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran.
authors: Omid
authors: O
authors: Akbarieh Hasani
authors: Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran.
authors: Najmeh
authors: N
authors: Kamali
authors: Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran.
authors: Shohreh
authors: S
authors: Vojouhi
authors: Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran.
authors: Sara
authors: S
authors: Baghban
authors: Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran.
authors: Azita
authors: A
authors: Aghaei
authors: Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran.
authors: Mohammad
authors: M
authors: Soukhtanloo
authors: Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran.
authors: Mahmoud
authors: M
authors: Hosseini
authors: Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran.
authors: Zahra
authors: Z
authors: Gholamnezhad
authors: Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran.
authors: Hassan
authors: H
authors: Rakhshandeh
authors: Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran.
authors: Abdolreza
authors: A
authors: Norouzy
authors: Health Sciences Research Center, Department of Biostatistics and Epidemiology, School of Health, Mashhad University of Medical Sciences, Mashhad, I. R. Iran.
authors: Habibollah
authors: H
authors: Esmaily
authors: Cardiovascular Research Center and Biochemistry of Nutrition Research center, School of Medicine, Mashhad University of Medical Sciences, Mashhad , I. R. Iran.
authors: Majid
authors: M
authors: Ghayour-Mobarhan
authors: Nutrition & Dietetics Research Group, Hammersmith Hospital, Imperial College London, Du Cane Road, London W12 0HS UK.
authors: Michael
authors: M
authors: Patterson
keywords: Appetite; Coriandrum sativum; Energy intake; Rat