title: C-myc protein expression in B-cell acute lymphoblastic leukemia, prognostic significance?
abstract: C-myc protein expression has been studied in mature B-cell lymphomas and overexpression has been associated with poor prognosis. We sought to determine the prognostic significance of c-myc protein expression in B-ALL. We found ≥ 20% c-myc expression to predict risk of persistent disease in all age groups (odds ratio 7.487, p=0.013). There was no statistically significant association between c-myc expression and risk of relapse or death in our study. Routine c-myc immunostaining may help identify higher risk patients and guide management of B-ALL. Additional studies are needed to further determine the molecular mechanisms and role of c-myc expression in B-ALL.
authors: Department of Pathology and Cell Biology, Division of Hematopathology, Columbia University Medical Center, New York, NY, USA.
authors: Ashleigh
authors: A
authors: Allen
authors: Department of Pathology and Cell Biology, Division of Hematopathology, Columbia University Medical Center, New York, NY, USA.
authors: Kamraan
authors: K
authors: Gill
authors: Department of Pathology and Cell Biology, Division of Hematopathology, Columbia University Medical Center, New York, NY, USA.
authors: Daniela
authors: D
authors: Hoehn
authors: Department of Pediatrics, Division of Hematology and Oncology, Columbia University Medical Center, New York, NY, USA.
authors: Maria
authors: M
authors: Sulis
authors: Department of Pathology and Cell Biology, Division of Hematopathology, Columbia University Medical Center, New York, NY, USA.
authors: Govind
authors: G
authors: Bhagat
authors: Department of Pathology and Cell Biology, Division of Hematopathology, Columbia University Medical Center, New York, NY, USA. Electronic address: ba2024@columbia.edu.
authors: Bachir
authors: B
authors: Alobeid
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000235:genetics* / Q000401:mortality; D011379:Prognosis; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics*; D016019:Survival Analysis; D055815:Young Adult
chemical_list: C489427:MYC protein, human; D016271:Proto-Oncogene Proteins c-myc
keywords: Acute lymphoblastic leukemia; Adult leukemia; B-ALL; C-myc; Childhood leukemia; Cytogenetics; Immunohistochemistry; Immunostaining; Prognosis; Protein expression