title: Glutamate metabolism in major depressive disorder.
abstract: Research on novel treatments for major depressive disorder focuses quite deeply on glutamate function, and this research would benefit from a brain-imaging technique that precisely quantified glutamate function. Signs of a specific form of glutamate-related dysfunction that could be targeted by novel therapies were found using novel, state-of-the-art techniques to address this issue.
authors: From the Department of Psychiatry, the Department of Diagnostic Imaging, and the Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, Conn.; the Clinical Neuroscience Research Unit, Connecticut Mental Health Center, New Haven; and the Clinical Neuroscience Division, National Center for PTSD, West Haven, Conn.
authors: Chadi G
authors: CG
authors: Abdallah
authors: Lihong
authors: L
authors: Jiang
authors: Henk M
authors: HM
authors: De Feyter
authors: Madonna
authors: M
authors: Fasula
authors: John H
authors: JH
authors: Krystal
authors: Douglas L
authors: DL
authors: Rothman
authors: Graeme F
authors: GF
authors: Mason
authors: Gerard
authors: G
authors: Sanacora
mesh_terms: D000328:Adult; D000368:Aged; D002247:Carbon Isotopes; D002952:Citric Acid Cycle; D003865:Major Depressive Disorder / Q000378:metabolism*; D005260:Female; D018698:Glutamic Acid / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000378:metabolism*; D008954:Models, Biological; D059906:Neuroimaging / Q000379:methods*; D009778:Occipital Lobe / Q000378:metabolism*; D011522:Protons; D055815:Young Adult; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D002247:Carbon Isotopes; D011522:Protons; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid