title: Claustrum projections to prefrontal cortex in the capuchin monkey (Cebus apella).
abstract: We examined the pattern of retrograde tracer distribution in the claustrum following intracortical injections into the frontal pole (area 10), and in dorsal (area 9), and ventral lateral (area 12) regions of the rostral prefrontal cortex in the tufted capuchin monkey (Cebus apella). The resulting pattern of labeled cells was assessed in relation to the three-dimensional geometry of the claustrum, as well as recent reports of claustrum-prefrontal connections in other primates. Claustrum-prefrontal projections were extensive, and largely concentrated in the ventral half of the claustrum, especially in the rostral 2/3 of the nucleus. Our data are consistent with a topographic arrangement of claustrum-cortical connections in which prefrontal and association cortices receive connections largely from the rostral and medial claustrum. Comparative aspects of claustrum-prefrontal topography across primate species and the implications of claustrum connectivity for understanding of cortical functional networks are explored, and we hypothesize that the claustrum may play a role in controlling or switching between resting state and task-associated cortical networks.
authors: Department of Physiology, Monash University Clayton, VIC, Australia.
authors: David H
authors: DH
authors: Reser
authors: Department of Physiology, Monash University Clayton, VIC, Australia ; Department of Psychology and Psychiatric Medicine, Monash University Clayton, VIC, Australia.
authors: Karyn E
authors: KE
authors: Richardson
authors: Department of Physiology, Monash University Clayton, VIC, Australia.
authors: Marina O
authors: MO
authors: Montibeller
authors: Department of Physiology, Monash University Clayton, VIC, Australia.
authors: Sherry
authors: S
authors: Zhao
authors: Department of Physiology, Monash University Clayton, VIC, Australia.
authors: Jonathan M H
authors: JM
authors: Chan
authors: Programa de Neurobiologia, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro Rio de Janeiro, Brazil.
authors: Juliana G M
authors: JG
authors: Soares
authors: Department of Physiology, Monash University Clayton, VIC, Australia.
authors: Tristan A
authors: TA
authors: Chaplin
authors: Programa de Neurobiologia, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro Rio de Janeiro, Brazil.
authors: Ricardo
authors: R
authors: Gattass
authors: Department of Physiology, Monash University Clayton, VIC, Australia ; Australian Research Council Centre of Excellence for Integrative Brain Function Clayton, VIC, Australia.
authors: Marcello G P
authors: MG
authors: Rosa
keywords: claustrum; cortical networks; neuroanatomy; prefrontal; primate