title: The effectiveness of the APACHE II, SAPS II and SOFA prognostic scoring systems in patients with haematological malignancies in the intensive care unit.
abstract: BACKGROUND
  Cancer-related mortality remains the second most common cause of death in Poland. In many cases, the occurrence of treatment-related complications requires admission to the intensive care unit (ICU). The aim of this study was to assess the clinical application of the APACHE II, SAPS II and SOFA scales to evaluate the risk of death in patients with haematological malignancies treated in the ICU.
  
  
  METHODS
  This study's analysis included 99 patients, who were each assigned to one of the following two groups: surviving patients who were discharged from the ICU (n = 24); and patients who died in the ICU (n = 75). Analysis was performed using demographic, clinical and laboratory data obtained during the patient's admission to the ICU and also during the first 24 hours of intensive therapy. Patient assessment was performed using the APACHE II, SAPS II and SOFA scoring systems as well as other clinical variables.
  
  
  RESULTS
  Univariate logistic regression identified the following risk factors of death in patients with haematological malignancies: systolic (P = 0.006), diastolic (P = 0.01) and mean arterial pressure values (P = 0.009); occurrence of acute kidney injury; neutrophil (P = 0.009) and platelet count in the peripheral blood (P = 0.001); and the SAPS II (P = 0.00005), SOFA (P = 0.00009) and APACHE II (P = 0.0007) scores. SAPS II score was the only independent risk factor of patient death in multivariate analysis (P = 0.0004; unitary OR 1.052 [95% CI: 1.022-1.082]).
  
  
  CONCLUSIONS
  Of all the applied patient assessment scales, only the SAPS II score was found to be useful in subjects with haematological malignancies hospitalised in the ICU.
authors: Chair and Department of Anaesthesiology and Intensive Therapy, Medical University of Gdańsk, Poland. wsawicka@gumed.edu.pl.
authors: Wioletta
authors: W
authors: Sawicka
authors: Radosław
authors: R
authors: Owczuk
authors: Magdalena Anna
authors: MA
authors: Wujtewicz
authors: Maria
authors: M
authors: Wujtewicz
mesh_terms: D018806:APACHE; D000328:Adult; D000368:Aged; D002395:Catecholamines / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D019337:Hematologic Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000503:physiopathology; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D012306:Risk; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D002395:Catecholamines