title: Orthogonally engineering matrix topography and rigidity to regulate multicellular morphology.
abstract: Programmable polymer substrates, which mimic the variable extracellular matrices in living systems, are used to regulate multicellular morphology, via orthogonally modulating the matrix topography and elasticity. The multicellular morphology is dependent on the competition between cell-matrix adhesion and cell-cell adhesion. Decreasing the cell-matrix adhesion provokes cytoskeleton reorganization, inhibits lamellipodial crawling, and thus enhances the leakiness of multicellular morphology.
authors: School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Singapore.
authors: Benhui
authors: B
authors: Hu
authors: Wenxiong
authors: W
authors: Shi
authors: Yun-Long
authors: YL
authors: Wu
authors: Wan Ru
authors: WR
authors: Leow
authors: Pingqiang
authors: P
authors: Cai
authors: Shuzhou
authors: S
authors: Li
authors: Xiaodong
authors: X
authors: Chen
mesh_terms: D000818:Animals; D040761:Biomimetic Materials / Q000737:chemistry*; D002448:Cell Adhesion / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D004285:Dogs; D004548:Elasticity; D005109:Extracellular Matrix / Q000502:physiology; D006801:Humans; D061986:MCF-7 Cells; D061985:Madin Darby Canine Kidney Cells; D011108:Polymers / Q000737:chemistry*; D011554:Pseudopodia / Q000502:physiology; D054457:Tissue Scaffolds
chemical_list: D011108:Polymers
keywords: cell-matrix anchorage; multicellular behavior; polymer matrix; rigidity; topography