title: HLA sensitisation: can it be prevented?
abstract: Human leukocyte antigen (HLA) sensitisation occurs after transfusion of blood products and transplantation. It can also happen spontaneously through cross-sensitisation from infection and pro-inflammatory events. Patients who are highly sensitised face longer waiting times on organ allocation programmes, more graft rejection and therefore more side effects of immunosuppression, and poorer graft outcomes. In this review, we discuss these issues, along with the limitations of modern HLA detection methods, and potential ways of decreasing HLA antibody development. We do not discuss the removal of antibodies after they have developed.
authors: Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Foundation Trust, Great Ormond Street, London, WC1N 3JH, UK, pediatric_nephrology@ucl.ac.uk.
authors: Lesley
authors: L
authors: Rees
authors: Jon Jin
authors: JJ
authors: Kim
mesh_terms: D001782:Blood Donors; D002648:Child; D017707:Erythrocyte Transfusion; D006680:HLA Antigens / Q000032:analysis / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D007518:Isoantibodies / Q000097:blood*; D016030:Kidney Transplantation
chemical_list: D006680:HLA Antigens; D007518:Isoantibodies