title: Hemocompatibility and anti-biofouling property improvement of poly(ethylene terephthalate) via self-polymerization of dopamine and covalent graft of lysine.
abstract: Inspired by the composition of adhesive proteins in mussels, we used self-polymerized dopamine to form a thin and surface-adherent polydopamine layer onto poly(ethylene terephthalate) (PET) sheet, followed by covalently grafting lysine (Lys) to improve hemocompatibility and anti-biofouling property. The obtained surfaces were characterized by water contact angle measurements, attenuated total reflectance Fourier transform infrared spectroscopy, and X-ray photoelectron spectroscopy analysis. The results of platelet adhesion and protein adsorption tests showed that Lys-immobilized PET was endowed with improved resistance to nonspecific protein adsorption and platelet adhesion. Cell assay results showed that PET-g-Lys surface could greatly inhibit NIH 3T3 cell adhesion. These works provide a facile hemocompatible and anti-fouling surface for biomedical applications.
authors: a Jiangsu Key Laboratory for Biofunctional Materials , Nanjing Normal University , Nanjing 210023 , P.R. China.
authors: Xuelian
authors: X
authors: Zhi
authors: Pengfei
authors: P
authors: Li
authors: Xucheng
authors: X
authors: Gan
authors: Weiwei
authors: W
authors: Zhang
authors: Tianjiao
authors: T
authors: Shen
authors: Jiang
authors: J
authors: Yuan
authors: Jian
authors: J
authors: Shen
mesh_terms: D000327:Adsorption; D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology; D057219:Biofouling / Q000517:prevention & control*; D002417:Cattle; D006801:Humans; D007211:Indoles / Q000737:chemistry*; D008239:Lysine / Q000737:chemistry*; D051379:Mice; D041681:NIH 3T3 Cells; D010973:Platelet Adhesiveness / Q000187:drug effects; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000494:pharmacology*; D011093:Polyethylene Terephthalates; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry; D013329:Structure-Activity Relationship; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D007211:Indoles; D011093:Polyethylene Terephthalates; D011108:Polymers; C568283:polydopamine; D012710:Serum Albumin, Bovine; D011092:Polyethylene Glycols; D008239:Lysine
keywords: anti-biofouling; dopamine; hemocompatibility; lysine; poly(ethylene terephthalate); zwitterions