title: "PEST control": regulation of molecular barcodes by tyrosine phosphatases.
abstract: The emerging concept of "molecular barcodes" refers to the dynamic combination of post-translational modifications, often of different nature (e.g., phosphorylation and ubiquitination) that gives rise to multiple forms of a protein which can relay distinct signals throughout a cell. In a recent Cell Research paper by Wang et al., the authors report that a PEST domain-containing tyrosine phosphatase, PTPN18, is able to regulate both phosphorylation and ubiquitination of the HER2 oncogene, barcoding HER2 for increased proteasomal degradation rather than for intracellular trafficking.
authors: Division of Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.
authors: Karen M
authors: KM
authors: Doody
authors: Division of Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.
authors: Nunzio
authors: N
authors: Bottini
mesh_terms: D020134:Catalytic Domain; D005260:Female; D006801:Humans; D054558:Protein Tyrosine Phosphatases, Non-Receptor / Q000737:chemistry* / Q000378:metabolism*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*; D054875:Ubiquitination
chemical_list: D054558:Protein Tyrosine Phosphatases, Non-Receptor; D018719:Erb-b2 Receptor Tyrosine Kinases