title: Discontinuation of somatic medication during psychiatric hospitalization.
abstract: BACKGROUND
  Psychiatric hospitalization can increase the risk of discontinuation of pharmacotherapy, which may negatively influence patients' health.
  
  
  OBJECTIVE
  To investigate the association between psychiatric hospitalization and discontinuation of somatic medication.
  
  
  METHODS
  A retrospective crossover study was performed in patients admitted to a psychiatric hospital (index date), who had got somatic medication dispensed during the 3 months prior to hospitalization. Discontinuation of somatic medication was investigated at the following time points: index date and 3, 6, and 9 months before the index date. Relative risks (RR) with 95% confidence intervals (95% CIs) of discontinuing somatic medication at the index date versus the time points before the index date were estimated using Cox regression.
  
  
  RESULTS
  In all, 471 hospitalized patients were included in the study; 38.9% of the patients were discontinuers on the index date. RR for discontinuation of ≥1 somatic medication was 1.88 (95% CI=1.55-2.27) at the index date compared with the other time points and highest for patients<45 years (RR=2.83; 95% CI=1.92-4.18).
  
  
  CONCLUSIONS
  Psychiatric hospitalization was associated with an almost doubled risk of discontinuation of somatic medication. Future studies should address the influence of discontinuation of care on patients' health.
authors: Department of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, the Netherlands Brocacef Ziekenhuisfarmacie, Department of Clinical Pharmacy, Den Dolder, the Netherlands.
authors: Heshu
authors: H
authors: Abdullah-Koolmees
authors: Department of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, the Netherlands Department of Clinical Pharmacy, Division Laboratory and Pharmacy, University Medical Center Utrecht, the Netherlands.
authors: Helga
authors: H
authors: Gardarsdottir
authors: Brocacef Ziekenhuisfarmacie, Department of Clinical Pharmacy, Den Dolder, the Netherlands.
authors: Lennart J
authors: LJ
authors: Stoker
authors: Altrecht Institute for Mental Health Care, Division of Willem Arntz, Utrecht, the Netherlands.
authors: Judith
authors: J
authors: Vuyk
authors: Department of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, the Netherlands Department of Clinical Pharmacy, Division Laboratory and Pharmacy, University Medical Center Utrecht, the Netherlands.
authors: Toine C G
authors: TC
authors: Egberts
authors: Department of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, the Netherlands Department of Clinical Pharmacy, Division Laboratory and Pharmacy, University Medical Center Utrecht, the Netherlands Altrecht Institute for Mental Health Care, Division of Willem Arntz, Utrecht, the Netherlands e.r.heerdink@uu.nl.
authors: Eibert R
authors: ER
authors: Heerdink
mesh_terms: D000328:Adult; D000368:Aged; D003266:Continuity of Patient Care; D018592:Cross-Over Studies; D004358:Drug Therapy; D005260:Female; D006778:Hospitals, Psychiatric; D006801:Humans; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D012189:Retrospective Studies; D012306:Risk
keywords: continuation of care; discontinuation; psychiatric hospital; psychiatry; somatic medication