title: Hydro-alcoholic extract of the root of Prangos ferulacea (L.) Lindl can improve serum glucose and lipids in alloxan-induced diabetic rats.
abstract: OBJECTIVE
  Diabetes mellitus manifests itself in a wide variety of complications and the symptoms of this disease are multifactorial. Previous studies proved that this disease is directly related to hyperglycemia and hyperlipidemia. The aim of this study was to investigate the hypoglycemic and hypolipidemic effects of hydroalcoholic extract of Prangos frulacea (L.) Lindl in alloxan-induced diabetic rats.
  
  
  METHODS
  Forty female Wistar rats with body weight of 200±20 g were randomly divided into five groups with eight rats per group. Diabetes was induced in rats by alloxan monohydrate at dose of 120 mg/kg body weight (BW) injected intraperitoneally. Hydro-alcoholic extract of the root and leaves with stems of P. frulacea at 100 mg/kg BW were given orally to diabetic rats daily for 4 weeks.
  
  
  RESULTS
  Diabetic rats (D) exhibited a significant (p<0.05) increase in the levels of the serum glucose, Total Cholesterol (TC), Triglycerides (TG), and LDL in comparison with the control group whereas their BW and serum HDL levels were decreased. In diabetic rats treated by root extract of P. frulacea, these parameters were reversed to the normal levels compared with diabetic group.
  
  
  CONCLUSIONS
  According to the results obtained, it was concluded that Root´s hydro-alcoholic extract of P. frulacea can be used in diabetics for the purpose of glucose and lipid profile reduction.
authors: Department of Biology, Faculty of Science, Urmia University, Urmia, I. R. Iran.
authors: Najme
authors: N
authors: Kafash Farkhad
authors: Department of Biology, Faculty of Science, Urmia University, Urmia, I. R. Iran.
authors: Farah
authors: F
authors: Farokhi
authors: Department of Artemias Rresearch, Faculty of Veterinary, Urmia University, Urmia, I. R. Iran.
authors: Amir
authors: A
authors: Tukmacki
authors: Department of Biology, Faculty of Science, Urmia University, Urmia, I. R. Iran.
authors: Khosro
authors: K
authors: Soltani Band
keywords: Diabetes Mellitus; Hypoglycemic; Hypolipidemic; Lipid profile; Prangos ferulacea (L.) Lindl