title: Alpha-mangostin promotes myoblast differentiation by modulating the gene-expression profile in C2C12 cells.
abstract: Alpha-mangostin, a xanthone contained mostly in mangosteen pericarp, has been reported to exert various biological functions. However, little is known about involvement of this xanthone in the muscle differentiation process. Here, we report the effect of α-mangostin on murine skeletal muscle-derived C2C12 myoblasts. α-mangostin stimulated myoblast differentiation leading to myotube formation. DNA microarray analysis revealed that genes associated with myoblast differentiation and muscle cell component formation were up-regulated in α-mangostin-treated cells. These results indicate that α-mangostin promotes myoblast differentiation through modulating the gene-expression profile in myoblasts.
authors: a Research and Development Division , Kikkoman Corporation , Noda , Japan.
authors: Taro
authors: T
authors: Horiba
authors: Masahiro
authors: M
authors: Katsukawa
authors: Keiko
authors: K
authors: Abe
authors: Yuji
authors: Y
authors: Nakai
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects*; D002460:Cell Line; D005786:Gene Expression Regulation / Q000187:drug effects*; D051379:Mice; D032446:Myoblasts / Q000166:cytology / Q000187:drug effects*; D020411:Oligonucleotide Array Sequence Analysis; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D059467:Transcriptome; D044004:Xanthones / Q000494:pharmacology*
chemical_list: D047428:Protein Kinase Inhibitors; D044004:Xanthones; C021053:mangostin
keywords: DNA microarray; alpha-mangostin; myoblast; myotube; xanthone