title: MicroRNA era: the importance for diagnosis and prognosis of adrenocortical tumors.
abstract: MicroRNAs play an essential role in posttranscriptional regulation of gene expression. They are evolutionary conserved, small, noncoding, 19-22-nucleotide RNAs, whose abnormalities, such as up- or downregulated expression, have been associated with several neoplasms, including adrenocortical tumors. Expression levels of distinct microRNAs can distinguish benign from malignant adrenal tumors. This current review provides recent data on the miRNAs profile in benign and malignant adrenocortical tumors diagnosed in adult and pediatric patients.
authors: Instituto do Câncer do Estado de São Paulo (ICESP), 05403-000 Sao Paulo, SP, Brazil.
authors: João Evangelista
authors: JE
authors: Bezerra
authors: Laboratório de Hormônios e Genética Molecular LIM/42 do Hospital das Clínicas, Disciplina de Endocrinologia e Metabologia da Faculdade de Medicina da Universidade de São Paulo, 05403-000 Sao Paulo, SP, Brazil.
authors: Ana Claudia
authors: AC
authors: Latronico
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D063646:Carcinogenesis / Q000235:genetics; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D011379:Prognosis
chemical_list: D035683:MicroRNAs