title: Type II natural killer T cells foster the antitumor activity of CpG-oligodeoxynucleotides.
abstract: Type II natural killer T (NKT) cells in cancer immunity are typically associated with suppression of tumor immunosurveillance through secretion of IL-13. We previously demonstrated that CpG oligonucleotide therapy activated Type II NKT cells to produce T helper type 1 (Th1) rather than T helper type 2 (Th2) cytokines. This cytokine skewing may manifest in Type II NKT cell antitumor properties in an immunotherapeutic setting.
authors: Department of Microbiology and Immunology; Feinberg School of Medicine; Northwestern University; Chicago, IL USA.
authors: Jie
authors: J
authors: Zhao
authors: Department of Microbiology and Immunology; Feinberg School of Medicine; Northwestern University; Chicago, IL USA.
authors: Sreya
authors: S
authors: Bagchi
authors: Department of Microbiology and Immunology; Feinberg School of Medicine; Northwestern University; Chicago, IL USA.
authors: Chyung-Ru
authors: CR
authors: Wang
keywords: CD1; NKT cells; immunotherapy; tumor immunity