title: [Results of dynamic assessment of melatonin receptor expression in lymphocytes in patients with acute mild and severe pancreatitis].
abstract: The authors present results of the investigation of melatonin receptors expression in lymphocytes in dynamics in 102 patients with acute pancreatitis of mild and severe form and in 50 volunteers. A correlated analysis was made between obtained results of laboratory and instrumental researches and clinical course of acute pancreatitis. The decrease of MT1 receptors expression was noted on 25% in patients with acute pancreatitis. The decline of MT2 receptors expression was observed on 40% of patients with acute severe pancreatitis and in a case of acute mild pancreatitis--on 15.5%, respectively. Values of MT1 and MT2 expression were equal between healthy volunteers. The decline of MT2 expression was a prognostic unfavourable sign. Obtained results of dynamic expression assessment of MT-receptors were presented as MT2/MT1 indices. Given index didn't change during disease, because of this, the index could be used as a prognostic development marker of destructive form of acute pancreatitis at the moment of patient's admission to hospital. Mean values of MT2/MT1 were determined for the purpose of universalization of used method (1.13 +/- 0.09 for mild form and 0.81 +/- 0.09 for severe form of acute pancreatitis, respectively).
authors: D Iu
authors: DIu
authors: Semenov
authors: Z Kh
authors: ZKh
authors: Osmanov
authors: A G
authors: AG
authors: Tonoian
authors: L G
authors: LG
authors: Shapkina
authors: A V
authors: AV
authors: Sokolov
authors: M V
authors: MV
authors: Gorchakova
mesh_terms: D000208:Acute Disease; D000328:Adult; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect / Q000379:methods; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008550:Melatonin / Q000378:metabolism*; D008875:Middle Aged; D010195:Pancreatitis / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology; D011237:Predictive Value of Tests; D011379:Prognosis; D044122:Receptor, Melatonin, MT1 / Q000032:analysis / Q000097:blood; D044123:Receptor, Melatonin, MT2 / Q000032:analysis / Q000097:blood; D015203:Reproducibility of Results; D012720:Severity of Illness Index
chemical_list: D044122:Receptor, Melatonin, MT1; D044123:Receptor, Melatonin, MT2; D008550:Melatonin