title: MDM2 oncogene, E3 ubiquitin protein ligase T309G polymorphism and risk of oesophageal or gastric cancer: meta-analysis of 15 studies.
abstract: OBJECTIVE
  To investigate the association between potentially functional MDM2 oncogene, E3 ubiquitin protein ligase (MDM2) T309G polymorphism and susceptibility to oesophageal or gastric cancer.
  
  
  METHODS
  Two investigators independently searched the PubMed and Chinese National Knowledge Infrastructure databases for studies published before September 2013.
  
  
  RESULTS
  Pooled results showed that the variant homozygous 309 GG genotype (versus TT) was significantly associated with increased risk of both oesophageal (odds ratio [OR] 0.77; 95% confidence interval [CI] 0.65, 0.90) and gastric cancer (OR 0.52; 95% CI 0.38, 0.72). Subgroup analysis revealed a 309 GG-associated increased risk for both cancer types in Asian populations, particularly among Chinese and Japanese ethnicity. When stratified for Helicobacter pylori infection and histological type of gastric cancer, the 309 GG-related risk was higher in H. pylori-positive patients (T versus G: OR 0.37; 95% CI 0.22, 0.63) and the association was stronger with intestinal (TT + TG versus GG: OR 0.68; 95% CI 0.54, 0.87) rather than diffuse gastric-cancer type.
  
  
  CONCLUSIONS
  The MDM2 T309G polymorphism may be significantly associated with increased susceptibility to oesophageal or gastric cancer, particularly among Eastern Asian populations.
authors: Department of General Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
authors: Wei
authors: W
authors: Shen
authors: Department of General Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
authors: Ping
authors: P
authors: Hu
authors: Department of General Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
authors: Jia-qing
authors: JQ
authors: Cao
authors: Department of General Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
authors: Xiu-xia
authors: XX
authors: Liu
authors: Department of General Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China jxncsjh@163.com.
authors: Jiang-hua
authors: JH
authors: Shao
mesh_terms: D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics*; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000235:genetics*; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*
chemical_list: C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2; D044767:Ubiquitin-Protein Ligases
keywords: E3 ubiquitin protein ligase (MDM2) gene; MDM2 oncogene; Oesophageal cancer; gastric cancer; meta-analysis; polymorphism; susceptibility