title: Could mean platelet volume in late first trimester of pregnancy predict intrauterine growth restriction and pre-eclampsia?
abstract: OBJECTIVE
  The present study aims to determine whether mean platelet volume (MPV) specified in late first trimester of pregnancy can be used to predict pre-eclampsia and intrauterine growth restriction (IUGR).
  
  
  METHODS
  This study prospectively reviews 200 healthy women with 11-14-week-old pregnancies.
  
  
  RESULTS
  Average pregnancy-associated plasma protein-A (PAPP-A) multiples of the median (MoM) value was significantly lower and MPV was significantly higher in pre-eclamptic pregnancies (P = 0.001 for both). MPV values of 10.5 fl or more can predict pre-eclampsia with 66.7% sensitivity and 63.8% specificity. The combination of MPV of 10.5 fl or more and PAPP-A MoM of 0.33 or less can predict pre-eclampsia with 75% sensitivity and 70.0% specificity. MPV values of 10.5 fl or more can predict IUGR with 82.4% sensitivity and 60.0% specificity. The combination of MPV of 10.5 fl or more and PAPP-A MoM of 0.33 or less can predict IUGR with 85.3% sensitivity and 62.0% specificity.
  
  
  CONCLUSIONS
  Increased MPV reflects enhanced platelet activation which may be caused by impairment in uteroplacental circulation. When MPV of 10.1 or more and PAPP-A MoM of 0.33 or less are combined as a threshold, the pregnancies that are destined to develop IUGR and pre-eclampsia can be predicted with considerably high sensitivity and specificity. The MPV and PAPP-A combination can be addressed as a useful biochemical tool for the prediction of IUGR and pre-eclampsia in late first trimester.
authors: Department of Obstetrics and Gynecology, Afyon Kocatepe University Medical Faculty Hospital, Afyonkarahisar, Turkey.
authors: Mine
authors: M
authors: Kanat-Pektas
authors: Ufuk
authors: U
authors: Yesildager
authors: Nadire
authors: N
authors: Tuncer
authors: Dagistan T
authors: DT
authors: Arioz
authors: Gulengul
authors: G
authors: Nadirgil-Koken
authors: Mehmet
authors: M
authors: Yilmazer
mesh_terms: D000328:Adult; D001792:Blood Platelets / Q000473:pathology*; D015331:Cohort Studies; D042241:Early Diagnosis; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D063847:Mean Platelet Volume; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis; D011296:Prenatal Diagnosis; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D014421:Turkey; D015854:Up-Regulation
chemical_list: D011266:Pregnancy-Associated Plasma Protein-A; C579283:PAPPA protein, human
keywords: intrauterine growth retardation; mean platelet volume; pre-eclampsia; pregnancy-associated protein-A