title: The association of percentage energy from fat and colon cancer risk among members of the US military.
abstract: Epidemiologic studies have previously reported an association between high fat intake and colon cancer risk. However, findings have generally been inconclusive. This study aimed to investigate the association between fat as a percentage of energy intake and colon cancer risk. Study subjects included 215 cases and 215 matched controls identified by the Defense Medical Surveillance System. Percentage energy from fat (Pfat) was estimated using a short dietary screener developed by the National Cancer Institute for two time periods: the year before the first blood draw and the year before colon cancer diagnosis. Conditional logistic regression analysis was used to assess the relationship between colon cancer risk and Pfat. Odds ratios and 95% confidence intervals (CIs) were calculated. Compared with the lowest quartile of Pfat, the adjusted odds of having colon cancer were 2.00 (95% CI 0.96-4.18), 2.83 (95% CI 1.41-5.66), and 3.37 (95% CI 1.58-7.17), respectively, for the second, third, and highest quartiles in the year before cancer diagnosis. Similar results were observed for Pfat at an earlier time point. Our findings suggest a positive association between Pfat and colon cancer in the US military population.
authors: aDepartment of Preventive Medicine and Biometrics, Division of Epidemiology and Biostatistics, Uniformed Services University of the Health Sciences bJohn P. Murtha Cancer Center, Walter Reed National Military Medical Center, Bethesda, Maryland, USA.
authors: Stephanie
authors: S
authors: Shao
authors: Tzu-Cheg
authors: TC
authors: Kao
authors: Janet
authors: J
authors: Eckhaus
authors: Jolie
authors: J
authors: Bourgeois
authors: Kanchana
authors: K
authors: Perera
authors: Kangmin
authors: K
authors: Zhu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003110:Colonic Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000378:metabolism; D004041:Dietary Fats / Q000009:adverse effects* / Q000378:metabolism; D002149:Energy Intake / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008889:Military Personnel; D012307:Risk Factors; D014481:United States / Q000453:epidemiology; D055815:Young Adult
chemical_list: D004041:Dietary Fats