title: Advances in in-situ product recovery (ISPR) in whole cell biotechnology during the last decade.
abstract: The review presents the state-of-the-art in the applications of in-situ product recovery (ISPR) in whole-cell biotechnology over the last 10years. It summarizes various ISPR-integrated fermentation processes for the production of a wide spectrum of bio-based products. A critical assessment of the performance of various ISPR concepts with respect to the degree of product enrichment, improved productivity, reduced process flows and increased yields is provided. Requirements to allow a successful industrial implementation of ISPR are also discussed. Finally, supporting technologies such as online monitoring, mathematical modeling and use of recombinant microorganisms with ISPR are presented.
authors: Flemish Institute for Technological Research (VITO), Business Unit Separation and Conversion Technology, Boeretang 200, 2400 Mol, Belgium. Electronic address: wouter.vanhecke@vito.be.
authors: Wouter
authors: W
authors: Van Hecke
authors: Flemish Institute for Technological Research (VITO), Business Unit Separation and Conversion Technology, Boeretang 200, 2400 Mol, Belgium. Electronic address: kaur.guneet07@gmail.com.
authors: Guneet
authors: G
authors: Kaur
authors: Flemish Institute for Technological Research (VITO), Business Unit Separation and Conversion Technology, Boeretang 200, 2400 Mol, Belgium. Electronic address: heleen.dewever@vito.be.
authors: Heleen
authors: H
authors: De Wever
mesh_terms: D001688:Biological Products / Q000302:isolation & purification / Q000378:metabolism; D019149:Bioreactors; D001709:Biotechnology / Q000379:methods*; D005285:Fermentation; D007218:Industrial Microbiology
chemical_list: D001688:Biological Products
keywords: ISPR-coupled whole-cell bioprocess; In-situ product recovery (ISPR); Microbial biotransformations