title: Noninvasive ventilation with complex critical care ventilator in the treatment of acute exacerbation of chronic obstructive pulmonary disease.
abstract: OBJECTIVE
  To compare the clinical effect of noninvasive positive-pressure ventilation (NIPPV), delivered via critical care ventilator or miniventilator, in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).
  
  
  METHODS
  Prospective comparison study. Patients with AECOPD underwent NIPPV via: miniventilator with BiLevel positive airway pressure (BiPAP; Group A); critical care ventilator with pressure support ventilation and positive end expiratory pressure (PSV + PEEP; Group B); critical care ventilator with pressure-synchronized intermittent mandatory ventilation (P-SIMV)+PSV + PEEP (Group C). Physiological parameters were recorded before, during and after ventilation.
  
  
  RESULTS
  Patients in Group C (n = 21) showed significantly better improvements in physiological parameters (compared with pretreatment values) than those in Group B (n = 20) or Group A (n = 22).
  
  
  CONCLUSIONS
  NIPPV delivered via critical care ventilator has a better treatment effect than miniventilator NIPPV in patients with AECOPD. The use of P-SIMV + PSV + PEEP mode provides a significantly better treatment effect than PSV + PEEP alone.
authors: Respiratory Department of Tianjin Medical University General Hospital, Tianjin, China.
authors: Jing
authors: J
authors: Zhang
authors: Respiratory Department of Tianjin Medical University General Hospital, Tianjin, China.
authors: Yan
authors: Y
authors: Wang
authors: Respiratory Department of Tianjin Medical University General Hospital, Tianjin, China.
authors: Jie
authors: J
authors: Cao
authors: Respiratory Department of Tianjin Medical University General Hospital, Tianjin, China.
authors: Bao-Yuan
authors: BY
authors: Chen
authors: Respiratory Department of Tianjin Medical University General Hospital, Tianjin, China Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, NC, USA zyyhxkfj@126.com jing.feng2@duke.edu.
authors: Jing
authors: J
authors: Feng
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003422:Critical Care; D005260:Female; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D063087:Noninvasive Ventilation / Q000295:instrumentation / Q000379:methods*; D011175:Positive-Pressure Respiration / Q000379:methods*; D011379:Prognosis; D011446:Prospective Studies; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications*; D012119:Respiration; D012131:Respiratory Insufficiency / Q000209:etiology / Q000517:prevention & control*; D012122:Ventilators, Mechanical
keywords: Noninvasive ventilation; chronic obstructive pulmonary disease; oronasal mask