title: Time resolved analysis of quetiapine and 7-OH-quetiapine in hair using LC/MS-MS.
abstract: Hair analysis is a powerful tool for retrospective drug analysis and has a wide application window. This article describes the simultaneous determination and quantification of the short-acting atypical antipsychotic drug quetiapine and its main metabolite 7-OH quetiapine in hair. A sensitive and accurate method for the determination of these two compounds was developed using high-performance liquid chromatography coupled to tandem mass spectrometry detection (LC-MS/MS). The method was applied to 10 real case samples. For five patients, a time resolved hair analysis was done. Results varied from 0.35 ng/mg to 10.21 ng/mg hair for quetiapine and from 0.02 ng/mg to 3.19 ng/mg hair for 7-OH-quetiapine.
authors: University of Zurich, Zurich Institute of Forensic Medicine, Center for Forensic Hairanalytics, Winterthurerstrasse 190/52, CH-8057 Zürich, Switzerland.
authors: Tina M
authors: TM
authors: Binz
authors: Laboratoire National de Santé, Service de Toxicologie, 1 rue Louis Rech, L-3555 Dudelange, Luxembourg.
authors: Michel
authors: M
authors: Yegles
authors: Laboratoire National de Santé, Service de Toxicologie, 1 rue Louis Rech, L-3555 Dudelange, Luxembourg.
authors: Serge
authors: S
authors: Schneider
authors: Toxicological Center, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium.
authors: Hugo
authors: H
authors: Neels
authors: Toxicological Center, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium. Electronic address: cleo.crunelle@gmail.com.
authors: Cleo L
authors: CL
authors: Crunelle
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000032:analysis*; D002853:Chromatography, Liquid; D003987:Dibenzothiazepines / Q000032:analysis*; D005260:Female; D006197:Hair / Q000737:chemistry*; D006801:Humans; D057230:Limit of Detection; D008297:Male; D008875:Middle Aged; D000069348:Quetiapine Fumarate; D053719:Tandem Mass Spectrometry; D013997:Time Factors
chemical_list: D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D000069348:Quetiapine Fumarate
keywords: 7-OH-quetiapine; Antipsychotics; Hair analysis; LC–MS/MS; Quetiapine