title: Effects of probiotic supplementation over 5 months on routine haematology and clinical chemistry measures in healthy active adults.
abstract: Use of probiotic-containing foods and probiotic supplements is increasing; however, few studies document safety and tolerability in conjunction with defined clinical end points. This paper reports the effects of 150 days of supplementation with either a single- (Bifidobacterium animalis subsp. lactis Bl-04) or a double-strain (Lactobacillus acidophilus NCFM and Bifidobacterium animalis subsp. lactis Bi-07) probiotic on routine haematology and clinical chemistry measures in healthy active adults. Pre- to post-intervention changes in laboratory measures were determined and compared between supplement and placebo groups. Overall there were few differences in routine haematology and clinical chemistry measures between supplement and placebo groups post-intervention. Exceptions included plasma calcium (P=0.03) and urea (P=0.015); however, observed changes were small and within assay-specific laboratory reference ranges. These data provide evidence supporting the use of these probiotic supplements over a period of 5 months in healthy active adults without obvious safety or tolerability issues.
authors: 1] Molecular Basis of Disease-Griffith Health Institute, Griffith University, Southport, QLD, Australia [2] School of Medical Science, Griffith University, Southport, QLD, Australia.
authors: A J
authors: AJ
authors: Cox
authors: 1] Molecular Basis of Disease-Griffith Health Institute, Griffith University, Southport, QLD, Australia [2] School of Medical Science, Griffith University, Southport, QLD, Australia.
authors: N P
authors: NP
authors: West
authors: Department of Physiology, Australian Institute of Sport, Canberra, ACT, Australia.
authors: P L
authors: PL
authors: Horn
authors: DuPont Nutrition & Health, Danisco Sweeteners Oy, Active Nutrition, Kantvik, Finland.
authors: M J
authors: MJ
authors: Lehtinen
authors: ACT Pathology, Canberra, ACT, Australia.
authors: G
authors: G
authors: Koerbin
authors: Department of Physiology, Australian Institute of Sport, Canberra, ACT, Australia.
authors: D B
authors: DB
authors: Pyne
authors: DuPont Nutrition & Health, Danisco Sweeteners Oy, Active Nutrition, Kantvik, Finland.
authors: S J
authors: SJ
authors: Lahtinen
authors: 1] Molecular Basis of Disease-Griffith Health Institute, Griffith University, Southport, QLD, Australia [2] Australian Institute of Sport, Canberra, ACT, Australia.
authors: P A
authors: PA
authors: Fricker
authors: 1] Molecular Basis of Disease-Griffith Health Institute, Griffith University, Southport, QLD, Australia [2] School of Medical Science, Griffith University, Southport, QLD, Australia.
authors: A W
authors: AW
authors: Cripps
mesh_terms: D000293:Adolescent; D000328:Adult; D001644:Bifidobacterium; D001774:Blood Chemical Analysis; D002118:Calcium / Q000097:blood; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D064368:Healthy Volunteers; D006405:Hematology / Q000379:methods*; D006801:Humans; D007779:Lactobacillus acidophilus; D008297:Male; D008875:Middle Aged; D019936:Probiotics / Q000008:administration & dosage*; D014508:Urea / Q000097:blood; D055815:Young Adult
chemical_list: D014508:Urea; D002118:Calcium