title: On the risk concerns of zacopride, a moderate IK1 channel agonist with cardiac protective action.
abstract: Zacopride, an IK1 agonist with moderate potency, could exert significant antiarrhythmic and cardiac protective effects. To date, there is no report to show that zacopride is proarrhythmic in both experimental studies and clinical trials. However, in certain cardiac pathological conditions, especially short QT syndrome and certain reentry tachycardia, zacopride is not suggested. Further studies are needed to precisely evaluate the potential arrhythmogenic risk of zacopride.
authors: *Department of Physiology, Shanxi Medical University, Taiyuan, China; and †Department of Physiology, Institute of Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China.
authors: Bo-Wei
authors: BW
authors: Wu
authors: Ji-Min
authors: JM
authors: Cao
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000473:pathology / Q000517:prevention & control*; D001549:Benzamides / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D004562:Electrocardiography; D006801:Humans; D008564:Membrane Potentials / Q000187:drug effects; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D024661:Potassium Channels, Inwardly Rectifying / Q000819:agonists* / Q000037:antagonists & inhibitors
chemical_list: D001549:Benzamides; D019086:Bridged Bicyclo Compounds, Heterocyclic; D002316:Cardiotonic Agents; D024661:Potassium Channels, Inwardly Rectifying; C055971:zacopride