title: The effect of metformin on androgen production in diabetic women with non-classic congenital adrenal hyperplasia.
abstract: Non-classic congenital adrenal hyperplasia (NC-CAH), one of the most common genetic disorders, is often associated with the clinical features of hyperandrogenism. This study included 19 women with recently diagnosed and previously untreated type 2 diabetes, 8 of whom suffered from NC-CAH, treated with metformin (2.55-3.0 g daily). Glucose homeostasis markers, plasma lipids, as well as plasma levels of 17-hydroxyprogesterone, androgens and gonadotropins were assessed at baseline and after 6 months of therapy. In both groups of patients, metformin reduced fasting plasma glucose, insulin resistance, triglycerides and glycated hemoglobin. Moreover, in patients with NC-CAH, but not in women with normal adrenal function, metformin decreased plasma levels of 17-hydroxyprogesterone, total and free testosterone, androstenedione and dehydroepiandrosterone sulphate. The obtained results suggest that metformin partially normalizes androgen production in symptomatic patients with NC-CAH.
authors: Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.
authors: R
authors: R
authors: Krysiak
authors: Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.
authors: B
authors: B
authors: Okopien
mesh_terms: D019326:17-alpha-Hydroxyprogesterone / Q000097:blood; D000312:Adrenal Hyperplasia, Congenital / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D000328:Adult; D000728:Androgens / Q000097:blood*; D001786:Blood Glucose; D003687:Dehydroepiandrosterone / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008687:Metformin / Q000627:therapeutic use*; D008875:Middle Aged; D013739:Testosterone / Q000097:blood; D016896:Treatment Outcome
chemical_list: D000728:Androgens; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D013739:Testosterone; D003687:Dehydroepiandrosterone; D019326:17-alpha-Hydroxyprogesterone; D008687:Metformin