title: Macroscopic type is a prognostic factor for recurrence-free survival after resection of gastric GIST.
abstract: BACKGROUND
  Accurate evaluation of the biological behavior of Gastrointestinal stromal tumor and careful selection of patients with a high risk for tumor recurrence are necessary. In the present study, we analyzed prognostic factors in patients with GIST.
  
  
  METHODS
  A total of 214 patients who had undergone curative resection of a localized primary gastric GIST without adjuvant therapy were enrolled in this retrospective study. Prognostic factors were analyzed. The growth pattern was classified as intramural, endoluminal, exoluminal, or mixed- type.
  
  
  RESULTS
  On univariate and multivariate analyses, recurrence was predicted by exoluminal or mixed-type (hazard ratio [HR]=3.7, p=0.043), tumor size of >3.5 cm (HR=7.1, p=0.01), and mitotic rate of >5/50 high-power fields (HR=7.9, p<0.001).
  
  
  CONCLUSIONS
  It is suggested that exoluminal or mixed-type is independently associated with recurrence of surgically resected gastric GIST in addition to tumor size and mitotic rate.
authors: Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan yo-chan.634@nifty.com.
authors: Hiroshi
authors: H
authors: Miyamoto
authors: Department of Surgery, Gastroenterological Center, Yokohama City University, Yokohama, Japan.
authors: Chikara
authors: C
authors: Kunisaki
authors: Department of Surgery, Kanto Medical Center NTT E.C., Tokyo, Japan.
authors: Yuichi
authors: Y
authors: Otsuka
authors: Department of Surgery, Yokohama City Hospital, Yokohama, Japan.
authors: Masazumi
authors: M
authors: Takahashi
authors: Department of Surgery, Yokosuka Kyosai Hospital, Yokosuka, Japan.
authors: Ryo
authors: R
authors: Takagawa
authors: Department of Surgery, Fujisawa City Hospital, Fujisawa, Japan.
authors: Koichiro
authors: K
authors: Misuta
authors: Department of Surgery, Yokosuka City Hospital, Yokosuka, Japan.
authors: Kunio
authors: K
authors: Kameda
authors: Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors: Hirochika
authors: H
authors: Makino
authors: Department of Surgery, National Hospital Organization Yokohama Medical Center, Yokohama, Japan.
authors: Goro
authors: G
authors: Matsuda
authors: Department of Surgery, Yokohama-City Minato Red Cross Hospital, Yokohama, Japan.
authors: Naotaka
authors: N
authors: Yamaguchi
authors: Department of Surgery, Ito Municipal Hospital, Ito, Japan.
authors: Noriyuki
authors: N
authors: Kamiya
authors: Department of Surgery, Yokohama Ekisaikai Hospital, Yokohama, Japan.
authors: Takashi
authors: T
authors: Murakami
authors: Department of Biostatistics and Epidemiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors: Satoshi
authors: S
authors: Morita
authors: Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors: Hirotoshi
authors: H
authors: Akiyama
authors: Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors: Itaru
authors: I
authors: Endo
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000209:etiology*; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery
keywords: GIST; Gastrointestinal stromal tumor; prognosis; risk of recurrence