title: Silver-catalyzed tandem hydroamination/hydroarylation of 1-(2-allylamino)phenyl-4-hydroxy-but-2-yn-1-ones to 1'-allylspiro[indene-1,2'-indolin]-3'-ones.
abstract: An efficient silver triflate-catalyzed tandem hydroamination/hydroarylation cascade generating 1'-allylspiro[indene-1,2'-indolin]-3'-ones from 1-(2-allylamino)phenyl-4-hydroxy-but-2-yn-1-ones is described. The reaction conditions are mild and general in scope and proceed to highly functionalized spiro-targets in high yield. This novel class of molecule possesses both the privileged indene and indolin-3-one scaffold, which may lead to possible pharmacological applications.
authors: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University , Singapore 637371, Singapore.
authors: Srinivasa Reddy
authors: SR
authors: Mothe
authors: Maria Laurentia
authors: ML
authors: Novianti
authors: Benjamin James
authors: BJ
authors: Ayers
authors: Philip Wai Hong
authors: PW
authors: Chan
mesh_terms: D002384:Catalysis; D003500:Cyclization; D007192:Indenes / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D008698:Mesylates / Q000737:chemistry; D015394:Molecular Structure; D012834:Silver / Q000737:chemistry*; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D007192:Indenes; D007211:Indoles; D008698:Mesylates; D013141:Spiro Compounds; D012834:Silver; C057812:indoline; C012077:trifluoromethanesulfonic acid