title: Copper-mediated C-H(sp²)/C-H(sp³) coupling of benzoic acid derivatives with ethyl cyanoacetate: an expedient route to an isoquinolinone scaffold.
abstract: A facile, copper-mediated, direct C-H(sp(2))/C-H(sp(3)) bond coupling of benzoic acid derivatives with ethyl cyanoacetate by the deployment of an 8-aminoquinoline moiety as a bidentate directing group is disclosed. Such a unique transformation provides a new strategy for the construction of an isoquinolinone scaffold as one of the privileged cores.
authors: CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, P. R. China. hliu@mail.shcnc.ac.cn.
authors: Wei
authors: W
authors: Zhu
authors: Dengyou
authors: D
authors: Zhang
authors: Nan
authors: N
authors: Yang
authors: Hong
authors: H
authors: Liu
mesh_terms: D000085:Acetates / Q000737:chemistry*; D000634:Aminoquinolines / Q000737:chemistry*; D019817:Benzoic Acid / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry; D003300:Copper / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry; D010084:Oxidation-Reduction; D011789:Quantum Theory
chemical_list: D000085:Acetates; D000634:Aminoquinolines; D056831:Coordination Complexes; D002244:Carbon; D003300:Copper; D006859:Hydrogen; D019817:Benzoic Acid; C080436:8-aminoquinoline; C007659:ethyl cyanoacetate