title: Effect of salt intake and potassium supplementation on serum renalase levels in Chinese adults: a randomized trial.
abstract: Renalase, a recently discovered enzyme released by the kidneys, breaks down blood-borne catecholamines and may thus regulate blood pressure (BP). Animal studies have suggested that high levels of dietary salt might reduce blood and kidney renalase levels. We conducted a randomized trial to assess the effects of altered salt and potassium intake on serum renalase levels and the relationship between serum renalase levels and BP in humans.Forty-two subjects (28-65 years of age) were selected from a rural community of northern China. All subjects were sequentially maintained on a low-salt diet for 7 days (3.0 g/day of NaCl), a high-salt diet for additional 7 days (18.0 g/day of NaCl), and a high-salt diet with potassium supplementation for final 7 days (18.0 g/day of NaCl + 4.5 g/day of KCl).Serum renalase levels were significantly higher than baseline levels during the low-salt diet intervention period. Renalase levels decreased with the change from the low-salt to high-salt diet, whereas dietary potassium prevented the decrease in serum renalase induced by the high-salt diet. There was a significant inverse correlation between the serum renalase level and 24-h urinary sodium excretion. No significant correlation was found between the renalase level and BP among the different dietary interventions.The present study indicates that variations in dietary salt intake and potassium supplementation affect the serum renalase concentration in Chinese subjects.
authors: Cardiovascular Department (YW, F-QL, DW, J-JM, K-YR, T-SG, CC, LW, L-KG, Z-YY), First Affiliated Hospital of Medical College, Xi'an Jiaotong University; and Key Laboratory of Environment and Genes Related to Diseases (YW, F-QL, DW, J-JM, K-YR, T-SG, CC, LW, Z-YY), Ministry of Education, Xi'an, P.R. China.
authors: Yang
authors: Y
authors: Wang
authors: Fu-Qiang
authors: FQ
authors: Liu
authors: Dan
authors: D
authors: Wang
authors: Jian-Jun
authors: JJ
authors: Mu
authors: Ke-Yu
authors: KY
authors: Ren
authors: Tong-Shuai
authors: TS
authors: Guo
authors: Chao
authors: C
authors: Chu
authors: Lan
authors: L
authors: Wang
authors: Li-Ke
authors: LK
authors: Geng
authors: Zu-Yi
authors: ZY
authors: Yuan
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D002681:China; D002940:Circadian Rhythm / Q000502:physiology; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000503:physiopathology / Q000652:urine; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000097:blood*; D011188:Potassium / Q000652:urine; D017419:Potassium, Dietary / Q000494:pharmacology*; D012964:Sodium / Q000652:urine; D017673:Sodium Chloride, Dietary / Q000494:pharmacology*
chemical_list: D017419:Potassium, Dietary; D017673:Sodium Chloride, Dietary; D012964:Sodium; D008995:Monoamine Oxidase; C521557:renalase; D011188:Potassium