title: Genome analysis of 17 extensively drug-resistant strains reveals new potential mutations for resistance.
abstract: We report the whole-genome sequence of an extensively drug-resistant (XDR) tuberculosis (TB) strain of Latin American-Mediterranean (LAM) lineage. This strain is phenotypically resistant to aminoglycosides, but carries no related mutations in rrs, tlyA, and eis. Through genome analysis comparison with 16 XDR strains, we found 218 non-synonymous single nucleotide polymorphisms (SNPs) shared that could confer resistance.
authors: hguio@ins.gob.pe.
authors: H
authors: H
authors: Guio
authors: Laboratorio de Biotecnología y Biología Molecular, Instituto Nacional de Salud (INS), Lima, Peru.
authors: D
authors: D
authors: Tarazona
authors: Laboratorio de Biotecnología y Biología Molecular, Instituto Nacional de Salud (INS), Lima, Peru.
authors: M
authors: M
authors: Galarza
authors: Laboratorio de Biotecnología y Biología Molecular, Instituto Nacional de Salud (INS), Lima, Peru.
authors: V
authors: V
authors: Borda
authors: Departamento de Neumología, Hospital Nacional Hipólito Unanue, Lima, Peru.
authors: R
authors: R
authors: Curitomay