title: The association between serum leptin and post stroke depression: results from a cohort study.
abstract: BACKGROUND
  Depression is a frequent mood disorder that affects around a third of stroke patients and has been associated with poorer outcomes. Our aim was to determine whether there was a relationship between inflammatory markers (leptin) and post-stroke depression (PSD).
  
  
  METHODS
  One hundred and ninety-one ischemic stroke patients admitted to the hospital within the first 24 hours after stroke onset were consecutively recruited and followed up for 3 months. Enzyme-linked immunosorbent assay (ELISA) was used to measure serum levels of leptin at admission. Based on the symptoms, diagnoses of depression were made in accordance with DSM-IV criteria for post-stroke depression at 3 month.
  
  
  RESULTS
  Forty-four patients (23.0%) were diagnosed as having major depression at 3 month. Patients with depression showed higher serum leptin levels at 3 month after stroke (32.2 [IQR, 20.8-57.7] v. 9.9 [IQR, 4.6-13.1]ng/ml, respectively; P = 0.000). Serum levels of leptin ≥20 ng/ml were independently associated with PSD [odds ratio (OR) 20.23, 95% confidence interval (CI) 9.11-51.26, P =  0.000], after adjusting for possible confounders.
  
  
  CONCLUSIONS
  Serum leptin levels elevated at admission were found to be associated with PSD and may provide a new proposal for the treatment of PSD.
authors: Department of Prevention and Health Care, Tianjin Nankai Hospital, Tianjin, P. R. China.
authors: Yan-tao
authors: YT
authors: Li
authors: Department of Clinical Research, Tianjin Nankai Hospital, Tianjin, P. R. China.
authors: Ye
authors: Y
authors: Zhao
authors: Department of Pediatrics, Tianjin Wuqing Hospital of Traditional Chinese Medicine, Tianjin, P. R. China.
authors: Hua-jing
authors: HJ
authors: Zhang
authors: Department of Neurology, Tianjin Nankai Hospital, Tianjin, P.R. China.
authors: Wen-li
authors: WL
authors: Zhao
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D015331:Cohort Studies; D003863:Depression / Q000097:blood / Q000209:etiology / Q000235:genetics* / Q000503:physiopathology*; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D020738:Leptin / Q000097:blood* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D020521:Stroke / Q000097:blood / Q000150:complications / Q000235:genetics* / Q000503:physiopathology
chemical_list: D015415:Biomarkers; D020738:Leptin; D002097:C-Reactive Protein