title: Kinetic resolution of oxazinones: rational exploration of chemical space through the design of experiments.
abstract: The organocatalytic kinetic resolution of 4-substituted oxazinones has been optimised (selectivity factor S up to 98, chiral oxazinone ee values up to 99.6 % (1 a-g) and product ee values up to 90 % (3 a-g)) in a rational way by applying the Design of Experiments (DoE) approach.
authors: Department of Chemistry, "Sapienza" University of Roma and Istituto di Chimica Biomolecolare del CNR, P.le Aldo Moro 5, 00185 Roma (Italy).
authors: Polyssena
authors: P
authors: Renzi
authors: Christel
authors: C
authors: Kronig
authors: Armando
authors: A
authors: Carlone
authors: Serap
authors: S
authors: Eröksüz
authors: Albrecht
authors: A
authors: Berkessel
authors: Marco
authors: M
authors: Bella
mesh_terms: D002384:Catalysis; D007700:Kinetics; D015394:Molecular Structure; D010078:Oxazines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D010078:Oxazines
keywords: design of experiments; kinetic resolution; organocatalysis; squaramides; thioureas