title: Spatial distribution of theobromine--a low MW drug--in tissues via matrix-free NALDI-MS imaging.
abstract: The ability of nano-assisted laser desorption-ionization mass spectrometry imaging (NALDI-IMS) to provide selective chemical monitoring with appropriate spatial distribution of a low molecular drug in a biological tissue was investigated. NALDI-IMS is a matrix-free laser desorption ionization (LDI) protocol based on imprinting of tissue constituents on a nanostructured surface. Using the accumulation of theobromine in rat kidney as a model, NALDI-IMS was found to provide well-resolved images of the special distribution of this low molecular weight (MW) drug in tissue.
authors: ThoMSon Mass Spectrometry Laboratory, Institute of Chemistry, University of Campinas, Campinas, SP, Brazil.
authors: Alessandra
authors: A
authors: Tata
authors: Chiara
authors: C
authors: Montemurro
authors: Andreia M
authors: AM
authors: Porcari
authors: Kamila C
authors: KC
authors: Silva
authors: José B
authors: JB
authors: Lopes de Faria
authors: Marcos N
authors: MN
authors: Eberlin
mesh_terms: D000818:Animals; D007668:Kidney / Q000737:chemistry / Q000378:metabolism; D008297:Male; D008970:Molecular Weight; D051381:Rats; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*; D013805:Theobromine / Q000032:analysis* / Q000737:chemistry*
chemical_list: D013805:Theobromine
keywords: drug distribution; kidney; low molecular weight (MW) drugs; nanoassisted laser desorption ionization imaging mass spectrometry (NALDI-IMS); theobromine