title: The PI3K/AKT/mTOR pathway in the pathophysiology and treatment of pituitary adenomas.
abstract: Pituitary adenomas are common intracranial neoplasms. Patients with these tumors exhibit a wide range of clinically challenging problems, stemming either from results of sellar mass effect in pituitary macroadenoma or the diverse effects of aberrant hormone production by adenoma cells. While some patients are cured/controlled by surgical resection and/or medical therapy, a proportion of patients exhibit tumors that are refractory to current modalities. New therapeutic approaches are needed for these patients. Activation of the AKT/phophotidylinositide-3-kinase pathway, including mTOR activation, is common in human neoplasia, and a number of therapeutic approaches are being employed to neutralize activation of this pathway in human cancer. This review examines the role of this pathway in pituitary tumors with respect to tumor biology and its potential role as a therapeutic target.
authors: Institute of Medical ScienceDepartment of Medical BiophysicsUniversity of Toronto, Toronto, Ontario, CanadaDivision of NeurosurgeryToronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8Ontario Cancer InstitutePrincess Margaret Hospital, Toronto, Ontario, CanadaEndocrine Oncology Site GroupPrincess Margaret Hospital, Toronto, Ontario, CanadaDepartment of Laboratory Medicine and PathobiologyUniversity of Toronto, Toronto, Ontario, CanadaInstitute of Medical ScienceDepartment of Medical BiophysicsUniversity of Toronto, Toronto, Ontario, CanadaDivision of NeurosurgeryToronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8Ontario Cancer InstitutePrincess Margaret Hospital, Toronto, Ontario, CanadaEndocrine Oncology Site GroupPrincess Margaret Hospital, Toronto, Ontario, CanadaDepartment of Laboratory Medicine and PathobiologyUniversity of Toronto, Toronto, Ontario, Canada.
authors: Eric
authors: E
authors: Monsalves
authors: Institute of Medical ScienceDepartment of Medical BiophysicsUniversity of Toronto, Toronto, Ontario, CanadaDivision of NeurosurgeryToronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8Ontario Cancer InstitutePrincess Margaret Hospital, Toronto, Ontario, CanadaEndocrine Oncology Site GroupPrincess Margaret Hospital, Toronto, Ontario, CanadaDepartment of Laboratory Medicine and PathobiologyUniversity of Toronto, Toronto, Ontario, Canada.
authors: Kyle
authors: K
authors: Juraschka
authors: Institute of Medical ScienceDepartment of Medical BiophysicsUniversity of Toronto, Toronto, Ontario, CanadaDivision of NeurosurgeryToronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8Ontario Cancer InstitutePrincess Margaret Hospital, Toronto, Ontario, CanadaEndocrine Oncology Site GroupPrincess Margaret Hospital, Toronto, Ontario, CanadaDepartment of Laboratory Medicine and PathobiologyUniversity of Toronto, Toronto, Ontario, Canada.
authors: Toru
authors: T
authors: Tateno
authors: Institute of Medical ScienceDepartment of Medical BiophysicsUniversity of Toronto, Toronto, Ontario, CanadaDivision of NeurosurgeryToronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8Ontario Cancer InstitutePrincess Margaret Hospital, Toronto, Ontario, CanadaEndocrine Oncology Site GroupPrincess Margaret Hospital, Toronto, Ontario, CanadaDepartment of Laboratory Medicine and PathobiologyUniversity of Toronto, Toronto, Ontario, Canada.
authors: Sameer
authors: S
authors: Agnihotri
authors: Institute of Medical ScienceDepartment of Medical BiophysicsUniversity of Toronto, Toronto, Ontario, CanadaDivision of NeurosurgeryToronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8Ontario Cancer InstitutePrincess Margaret Hospital, Toronto, Ontario, CanadaEndocrine Oncology Site GroupPrincess Margaret Hospital, Toronto, Ontario, CanadaDepartment of Laboratory Medicine and PathobiologyUniversity of Toronto, Toronto, Ontario, Canada.
authors: Sylvia L
authors: SL
authors: Asa
authors: Institute of Medical ScienceDepartment of Medical BiophysicsUniversity of Toronto, Toronto, Ontario, CanadaDivision of NeurosurgeryToronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8Ontario Cancer InstitutePrincess Margaret Hospital, Toronto, Ontario, CanadaEndocrine Oncology Site GroupPrincess Margaret Hospital, Toronto, Ontario, CanadaDepartment of Laboratory Medicine and PathobiologyUniversity of Toronto, Toronto, Ontario, CanadaInstitute of Medical ScienceDepartment of Medical BiophysicsUniversity of Toronto, Toronto, Ontario, CanadaDivision of NeurosurgeryToronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8Ontario Cancer InstitutePrincess Margaret Hospital, Toronto, Ontario, CanadaEndocrine Oncology Site GroupPrincess Margaret Hospital, Toronto, Ontario, CanadaDepartment of Laboratory Medicine and PathobiologyUniversity of Toronto, Toronto, Ontario, CanadaInstitute of Medical ScienceDepartment of Medical BiophysicsUniversity of Toronto, Toronto, Ontario, CanadaDivision of NeurosurgeryToronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8Ontario Cancer InstitutePrincess Margaret Hospital, Toronto, Ontario, CanadaEndocrine Oncology Site GroupPrincess Margaret Hospital, Toronto, Ontario, CanadaDepartment of Laboratory Medicine and PathobiologyUniversity of Toronto, Toronto, Ontario, Canada.
authors: Shereen
authors: S
authors: Ezzat
authors: Institute of Medical ScienceDepartment of Medical BiophysicsUniversity of Toronto, Toronto, Ontario, CanadaDivision of NeurosurgeryToronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8Ontario Cancer InstitutePrincess Margaret Hospital, Toronto, Ontario, CanadaEndocrine Oncology Site GroupPrincess Margaret Hospital, Toronto, Ontario, CanadaDepartment of Laboratory Medicine and PathobiologyUniversity of Toronto, Toronto, Ontario, CanadaInstitute of Medical ScienceDepartment of Medical BiophysicsUniversity of Toronto, Toronto, Ontario, CanadaDivision of NeurosurgeryToronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8Ontario Cancer InstitutePrincess Margaret Hospital, Toronto, Ontario, CanadaEndocrine Oncology Site GroupPrincess Margaret Hospital, Toronto, Ontario, CanadaDepartment of Laboratory Medicine and PathobiologyUniversity of Toronto, Toronto, Ontario, Canada gelareh.zadeh@uhn.on.ca.
authors: Gelareh
authors: G
authors: Zadeh
mesh_terms: D000236:Adenoma / Q000188:drug therapy / Q000378:metabolism*; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D006801:Humans; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D010911:Pituitary Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt; D058570:TOR Serine-Threonine Kinases; C546842:MTOR protein, human
keywords: RAD001; mTOR; mTOR inhibitor; pituitary adenoma; rapamycin