title: Attenuation correction synthesis for hybrid PET-MR scanners: application to brain studies.
abstract: Attenuation correction is an essential requirement for quantification of positron emission tomography (PET) data. In PET/CT acquisition systems, attenuation maps are derived from computed tomography (CT) images. However, in hybrid PET/MR scanners, magnetic resonance imaging (MRI) images do not directly provide a patient-specific attenuation map. The aim of the proposed work is to improve attenuation correction for PET/MR scanners by generating synthetic CTs and attenuation maps. The synthetic images are generated through a multi-atlas information propagation scheme, locally matching the MRI-derived patient's morphology to a database of MRI/CT pairs, using a local image similarity measure. Results show significant improvements in CT synthesis and PET reconstruction accuracy when compared to a segmentation method using an ultrashort-echo-time MRI sequence and to a simplified atlas-based method.
authors: Ninon
authors: N
authors: Burgos
authors: M Jorge
authors: MJ
authors: Cardoso
authors: Kris
authors: K
authors: Thielemans
authors: Marc
authors: M
authors: Modat
authors: Stefano
authors: S
authors: Pedemonte
authors: John
authors: J
authors: Dickson
authors: Anna
authors: A
authors: Barnes
authors: Rebekah
authors: R
authors: Ahmed
authors: Colin J
authors: CJ
authors: Mahoney
authors: Jonathan M
authors: JM
authors: Schott
authors: John S
authors: JS
authors: Duncan
authors: David
authors: D
authors: Atkinson
authors: Simon R
authors: SR
authors: Arridge
authors: Brian F
authors: BF
authors: Hutton
authors: Sebastien
authors: S
authors: Ourselin
mesh_terms: D000465:Algorithms; D001921:Brain / Q000033:anatomy & histology / Q000000981:diagnostic imaging; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D064847:Multimodal Imaging / Q000379:methods*; D059906:Neuroimaging / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods*