title: Decreased plasma neurotrophin-4/5 levels in bipolar disorder patients in mania.
abstract: OBJECTIVE
  To evaluate two poorly explored neurotrophins (NT), NT-3 and NT-4/5, in bipolar disorder (BD).
  
  
  METHODS
  Forty patients with type I BD (18 in remission and 22 in mania) and 25 healthy controls matched for age, gender, and educational attainment were enrolled in this study. All subjects were assessed by the Mini-International Neuropsychiatric Interview; the Young Mania Rating Scale and the Hamilton Depression Rating Scale were used to evaluate severity of symptoms in BD patients. Plasma levels of NT-3 and NT-4/5 were measured by enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  BD patients in mania presented decreased NT-4/5 plasma levels in comparison with controls (p < 0.05). There were no significant differences in NT-3 plasma levels between BD patients and controls.
  
  
  CONCLUSIONS
  These findings corroborate the view that neurotrophin dysfunction is associated with mood states in patients with BD.
authors: Interdisciplinary Laboratory of Medical Investigation, School of Medicine, Universidade Federal de Minas Gerais (UFMJ), Belo Horizonte, MG, Brazil.
authors: Izabela G
authors: IG
authors: Barbosa
authors: Interdisciplinary Laboratory of Medical Investigation, School of Medicine, Universidade Federal de Minas Gerais (UFMJ), Belo Horizonte, MG, Brazil.
authors: Isabela B
authors: IB
authors: Morato
authors: Instituto de Previdência dos Servidores do Estado de Minas Gerais (IPSEMG), Belo Horizonte, MG, Brazil.
authors: Rodrigo B
authors: RB
authors: Huguet
authors: Instituto de Previdência dos Servidores do Estado de Minas Gerais (IPSEMG), Belo Horizonte, MG, Brazil.
authors: Fabio L
authors: FL
authors: Rocha
authors: Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, Bethesda, MD, USA, Laboratory of Neuroscience (LIM-27), Institute and Department of Psychiatry, Universidade de São Paulo (USP), São Paulo, SP, Brazil.
authors: Rodrigo
authors: R
authors: Machado-Vieira
authors: Interdisciplinary Laboratory of Medical Investigation, School of Medicine, Universidade Federal de Minas Gerais (UFMJ), Belo Horizonte, MG, Brazil.
authors: Antônio L
authors: AL
authors: Teixeira
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001714:Bipolar Disorder / Q000097:blood* / Q000503:physiopathology; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000097:blood*; D020933:Neurotrophin 3 / Q000097:blood; D011569:Psychiatric Status Rating Scales; D012016:Reference Values; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers; D009414:Nerve Growth Factors; D020933:Neurotrophin 3; C071951:neurotrophin 5; C073922:neurotrophin 4