title: Neurodevelopmental and behavioral effects of nonylphenol exposure during gestational and breastfeeding period on F1 rats.
abstract: Nonylphenols (NP) are endocrine-disruptors known to be widely present in our environment. This study evaluated the effects of 4-n-NP on neurobehavioral development and memory capacity after perinatal exposure on the offspring rats. Dams were gavaged with 4-n-NP (0, 50 and 200mg/kg/day) from gestational day 5 to postnatal day (PND) 21. Dams exposed to the higher dose lost weight during gestation and had a longer gestational duration. Juvenile female pups of the 200mg 4-n-NP/kg/day group were lighter. Their thyroid somatic index (TSI) was also affected. For male pups, a decrease of TSI at weaning for the 200mg 4-n-NP/kg/day group and an increase of GSI for the 50mg 4-n-NP/kg/day group were observed. Physical maturation (incisives and eyes) were likewise affected. In open field (OF) tests, females were more active than males. In the first OF (PND 36), a treatment effect was observed only for males, particularly for the high dose group, which became as active as females. The second OF (PND 71) showed few differences between groups (treated vs control), the gender difference whatever the dose was not abolished. In the Morris Water Maze test, the study of the first 30s showed that females (200mg/kg/day) were mainly affected. Their performances were improved by 4-n-NP. These effects were particularly important for the first short-term memory test and observed to a lesser extent in the second evaluation of the long-term memory (PND 69). These data showed that perinatal 4-n-NP exposure induced behavioral and neuro-developmental impairments from 50mg/kg/day.
authors: LUNAM Université, Université de Nantes, MMS, EA 2160, 9 Rue Bias, Nantes F-44035, France; LUNAM Université, Oniris, Laboratoire d'Étude des Résidus et Contaminants dans les Aliments (LABERCA), Nantes F-44307, France; LUNAM Université, Université Catholique de l'Ouest, 3, Place André Leroy, Angers F-49000, France. Electronic address: mickael.couderc@univ-nantes.fr.
authors: Mickaël
authors: M
authors: Couderc
authors: LUNAM Université, Université de Nantes, MMS, EA 2160, 9 Rue Bias, Nantes F-44035, France.
authors: Allison
authors: A
authors: Gandar
authors: LUNAM Université, Université de Nantes, MMS, EA 2160, 9 Rue Bias, Nantes F-44035, France.
authors: Abderrahmane
authors: A
authors: Kamari
authors: LUNAM Université, Université de Nantes, FED 4203, INSERM UMS 016, UMS C 3556, Structure Fédérative de Recherche François Bonamy, Nantes F-44035, France.
authors: Yohann
authors: Y
authors: Allain
authors: LUNAM Université, Université de Nantes, MMS, EA 2160, 9 Rue Bias, Nantes F-44035, France.
authors: Aurore
authors: A
authors: Zalouk-Vergnoux
authors: LUNAM Université, Université de Nantes, MMS, EA 2160, 9 Rue Bias, Nantes F-44035, France.
authors: Christine
authors: C
authors: Herrenknecht
authors: LUNAM Université, Oniris, Laboratoire d'Étude des Résidus et Contaminants dans les Aliments (LABERCA), Nantes F-44307, France.
authors: Bruno
authors: B
authors: Le Bizec
authors: LUNAM Université, Université de Nantes, MMS, EA 2160, 9 Rue Bias, Nantes F-44035, France; LUNAM Université, Université Catholique de l'Ouest, 3, Place André Leroy, Angers F-49000, France.
authors: Catherine
authors: C
authors: Mouneyrac
authors: LUNAM Université, Université de Nantes, MMS, EA 2160, 9 Rue Bias, Nantes F-44035, France.
authors: Laurence
authors: L
authors: Poirier
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D052244:Endocrine Disruptors / Q000633:toxicity*; D005260:Female; D005865:Gestational Age; D006066:Gonads / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D018811:Maternal Exposure; D008568:Memory / Q000187:drug effects*; D009043:Motor Activity / Q000187:drug effects*; D009420:Nervous System / Q000187:drug effects / Q000254:growth & development; D010636:Phenols / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012737:Sex Factors; D013961:Thyroid Gland / Q000187:drug effects
chemical_list: D052244:Endocrine Disruptors; D010636:Phenols; C025256:nonylphenol
keywords: 4-n-Nonyphenol; Learning and memory capacity; Neurobehavioral development; Offspring rats