title: Tumor vascularity in ovarian cancer: T cells need breathing room.
abstract: Tumor-infiltrating lymphocytes (TILs) are crucial for effective antitumor responses. However, hypoxia can skew T-cell differentiation and function, thereby perturbing TILs. We have demonstrated that TILs and their immune function are associated with tumor vascularization. These features are prognostic for improved disease-specific survival in ovarian cancer. Thus, new immunotherapies should consider how hypoxia impacts antitumor immunity.
authors: Trev and Joyce Deeley Research Centre; BC Cancer Agency; Victoria, BC Canada ; Department of Biochemistry and Microbiology; University of Victoria; Victoria, BC Canada.
authors: David
authors: D
authors: Neilson
authors: Trev and Joyce Deeley Research Centre; BC Cancer Agency; Victoria, BC Canada ; Department of Biochemistry and Microbiology; University of Victoria; Victoria, BC Canada.
authors: Sarah
authors: S
authors: MacPherson
authors: Trev and Joyce Deeley Research Centre; BC Cancer Agency; Victoria, BC Canada ; Department of Biochemistry and Microbiology; University of Victoria; Victoria, BC Canada.
authors: Katelin N
authors: KN
authors: Townsend
authors: Trev and Joyce Deeley Research Centre; BC Cancer Agency; Victoria, BC Canada ; Department of Biochemistry and Microbiology; University of Victoria; Victoria, BC Canada.
authors: Julian J
authors: JJ
authors: Lum
keywords: CD31; T cell; VEGF; autophagy; hypoxia; ovarian cancer