title: SIRT1 in cardiovascular aging.
abstract: Cardiovascular disease (CVD) is the leading cause of death worldwide, with aging as the key independent risk factor. Effective interventions are necessary to delay aging. Sirtuin1 (SIRT1), a NAD(+)-dependent histone deacetylase, is closely related to lifespan extension. SIRT1 exerts beneficial effects on aging and age-related diseases, such as atherosclerosis. In this review, we summarize the current knowledge on the functions of SIRT1 in cardiovascular aging, focusing on the underlying molecular mechanisms, including inhibition of oxidative stress and inflammation, and induction of autophagy. We also demonstrate that moderate up-regulation or activation of SIRT1 in cardiovascular aging and age-related CVD may confer important application values.
authors: Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang City 421001, Hunan Province, China.
authors: Xin-Yuan
authors: XY
authors: Luo
authors: Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang City 421001, Hunan Province, China.
authors: Shun-Lin
authors: SL
authors: Qu
authors: Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang City 421001, Hunan Province, China.
authors: Zhi-Han
authors: ZH
authors: Tang
authors: Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang City 421001, Hunan Province, China.
authors: Yuan
authors: Y
authors: Zhang
authors: Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang City 421001, Hunan Province, China.
authors: Mi-Hua
authors: MH
authors: Liu
authors: Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang City 421001, Hunan Province, China.
authors: Juan
authors: J
authors: Peng
authors: Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang City 421001, Hunan Province, China.
authors: Hui
authors: H
authors: Tang
authors: Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang City 421001, Hunan Province, China.
authors: Kang-Lun
authors: KL
authors: Yu
authors: Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang City 421001, Hunan Province, China.
authors: Chi
authors: C
authors: Zhang
authors: Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang City 421001, Hunan Province, China.
authors: Zhong
authors: Z
authors: Ren
authors: Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang City 421001, Hunan Province, China. Electronic address: zsjianglab@aliyun.com.
authors: Zhi-Sheng
authors: ZS
authors: Jiang
mesh_terms: D000375:Aging / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000378:metabolism*; D002319:Cardiovascular System / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology; D056564:Sirtuin 1 / Q000096:biosynthesis*
chemical_list: C447939:SIRT1 protein, human; D056564:Sirtuin 1
keywords: Anti-aging strategies; Autophagy; Cardiovascular aging; Inflammation; Oxidative stress; SIRT1