title: Sarcoma response to targeted therapy dynamically polarizes tumor-associated macrophages.
abstract: In gastrointestinal stromal tumor (GIST), the most common human sarcoma, tumor-associated macrophages (TAMs) have been found to be abundant and surprisingly M1-like, exhibiting antitumoral activities. However, TAMs switch to M2-like during the course of imatinib therapy, but upon drug resistance TAMs revert to M1-like. Therefore, the oncologic efficacy of TAM depletion may depend on tumor type and treatment status.
authors: Memorial Sloan-Kettering Cancer Center; New York, NY USA.
authors: Michael J
authors: MJ
authors: Cavnar
authors: Memorial Sloan-Kettering Cancer Center; New York, NY USA.
authors: Ronald P
authors: RP
authors: DeMatteo
keywords: C/EBPβ; CSF1R; gastrointestinal stromal tumor; macrophage; tumor-associated macrophage