title: Inhalation of carbon black nanoparticles aggravates pulmonary inflammation in mice.
abstract: An increasing number of recent studies have focused on the impact of particulate matter on human health. As a model for atmospheric particulate inhalation, we investigated the effects of inhaled carbon black nanoparticles (CBNP) on mice with bleomycin-induced pulmonary fibrosis. The CNBPs were generated by a novel aerosolization process, and the mice were exposed to the aerosol for 4 hours. We found that CBNP inhalation exacerbated lung inflammation, as evidenced by histopathology analysis and by the expression levels of interleukin-6 protein, fibronectin, and interferon-γ mRNAs in lung tissues. Notably, fibronectin mRNA expression showed a statistically significant increase in expression after CBNP exposure. These data suggest that the concentration of CBNPs delivered (calculated to be 12.5 μg/m(3)) can aggravate lung inflammation in mice. Our results also suggest that the inhalation of ultrafine particles like PM 2.5 is an impactful environmental risk factor for humans, particularly in susceptible populations with predisposing lung conditions.
authors: Inhalation Toxicology Center, Korea Institute of Toxicology, Jeonbuk, Korea ; Toxicology and Pharmacology, Korea University of Science and Technology, Daejeon, Korea.
authors: Devina
authors: D
authors: Saputra
authors: Institute for Occupational Health, Yonsei University College of Medicine, Seoul, Korea.
authors: Jin-Ha
authors: JH
authors: Yoon
authors: Inhalation Toxicology Center, Korea Institute of Toxicology, Jeonbuk, Korea.
authors: Hyunju
authors: H
authors: Park
authors: Inhalation Toxicology Center, Korea Institute of Toxicology, Jeonbuk, Korea.
authors: Yongju
authors: Y
authors: Heo
authors: Inhalation Toxicology Center, Korea Institute of Toxicology, Jeonbuk, Korea.
authors: Hyoseon
authors: H
authors: Yang
authors: Inhalation Toxicology Center, Korea Institute of Toxicology, Jeonbuk, Korea.
authors: Eun Ji
authors: EJ
authors: Lee
authors: Inhalation Toxicology Center, Korea Institute of Toxicology, Jeonbuk, Korea.
authors: Sangjin
authors: S
authors: Lee
authors: Inhalation Toxicology Center, Korea Institute of Toxicology, Jeonbuk, Korea.
authors: Chang-Woo
authors: CW
authors: Song
authors: Inhalation Toxicology Center, Korea Institute of Toxicology, Jeonbuk, Korea ; Toxicology and Pharmacology, Korea University of Science and Technology, Daejeon, Korea.
authors: Kyuhong
authors: K
authors: Lee
keywords: Carbon black nanoparticles; Inhalation toxicity; Lung inflammation; Ultrafine particle