title: Quantitative and qualitative examination of particle-particle interactions using colloidal probe nanoscopy.
abstract: Colloidal Probe Nanoscopy (CPN), the study of the nano-scale interactive forces between a specifically prepared colloidal probe and any chosen substrate using the Atomic Force Microscope (AFM), can provide key insights into physical interactions present within colloidal systems. Colloidal systems are widely existent in several applications including, pharmaceuticals, foods, paints, paper, soil and minerals, detergents, printing and much more.1-3 Furthermore, colloids can exist in many states such as emulsions, foams and suspensions. Using colloidal probe nanoscopy one can obtain key information on the adhesive properties, binding energies and even gain insight into the physical stability and coagulation kinetics of the colloids present within. Additionally, colloidal probe nanoscopy can be used with biological cells to aid in drug discovery and formulation development. In this paper we describe a method for conducting colloidal probe nanoscopy, discuss key factors that are important to consider during the measurement, and show that both quantitative and qualitative data that can be obtained from such measurements.
authors: Faculty of Pharmacy, University of Sydney.
authors: Dexter
authors: D
authors: D'Sa
authors: Faculty of Pharmacy, University of Sydney.
authors: Hak-Kim
authors: HK
authors: Chan
authors: Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University.
authors: Hae-Won
authors: HW
authors: Kim
authors: Faculty of Pharmacy, University of Sydney; Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University; wojciech.chrzanowski@sydney.edu.au.
authors: Wojciech
authors: W
authors: Chrzanowski
mesh_terms: D003102:Colloids / Q000737:chemistry*; D018625:Microscopy, Atomic Force / Q000379:methods*; D036103:Nanotechnology / Q000379:methods*
chemical_list: D003102:Colloids