title: Choroid plexus papilloma-A case highlighting the challenges of extrapolating pediatric chemotherapy regimens to adult populations.
abstract: The treatment of adults who present with rare pediatric tumors is not characterized well in the literature. We report an instance of a 40-year-old African American woman with a diagnosis of choroid plexus carcinoma admitted to the intensive care unit for severe sepsis seven days after receiving chemotherapy consisting of carboplatin (350 mg/m(2) on Days 1 and 2 plus etoposide 100 mg/m(2) on Days 1-5). Her laboratory results were significant for an absolute neutrophil count of 0/µL and blood cultures positive for Capnocytophagia species. She was supported with broad spectrum antibiotics and myeloid growth factors. She eventually recovered and was discharged in stable condition. The management of adults with malignancies most commonly seen in pediatric populations presents substantial challenges. There are multiple age-specific differences in renal and hepatic function that explain the need for higher dosing in pediatric patients without increasing the risk of toxicity. Furthermore, differences in pharmacokinetic parameters such as absorption, distribution, and clearance are present but are less likely to affect patients. It is expected that the pediatric population will have more bone marrow reserve and, therefore, less susceptible to myelosuppression. The extrapolation of pediatric dosing to an adult presents a problematic situation in treating adults with malignancies that primarily effect pediatric patients. We recommend extrapolating from adult treatment regimens with similar agents rather than extrapolating from pediatric treatment regimens to reduce the risk of toxicity. We also recommend the consideration of adding myeloid growth factors. If the treatment is tolerated without significant toxicity, dose escalation can be considered.
authors: Department of Internal Medicine, University of Texas Southwestern Medical Center, USA.
authors: Stephen L
authors: SL
authors: Barman
authors: School of Pharmacy, Texas Tech University Health Sciences Center, USA gary.w.jean@ttuhsc.edu.
authors: Gary W
authors: GW
authors: Jean
authors: Department of Internal Medicine, University of Texas Southwestern Medical Center, USA.
authors: William M
authors: WM
authors: Dinsfriend
authors: Department of Internal Medicine, University of Texas Southwestern Medical Center, USA Harold C. Simmons Cancer Center, University of Texas Southwestern Medical Center, USA.
authors: David E
authors: DE
authors: Gerber
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D020288:Papilloma, Choroid Plexus / Q000188:drug therapy*; D010372:Pediatrics
chemical_list: D003520:Cyclophosphamide; D016190:Carboplatin
keywords: Choroid plexus papilloma; chemotherapy; dosing; oncology; pediatric hematology–oncology