title: Intraoperative radiation therapy opportunities for clinical practice normalization: Data recording and innovative development.
abstract: BACKGROUND
  Intraoperative radiotherapy (IORT) refers to the delivery of a high dose of radiation at the time of surgery.
  
  
  OBJECTIVE
  To analyze clinical and research-oriented innovative activities developed in a 17-year period using intraoperative electron-radiation therapy (IOeRT) as a component of treatment in a multidisciplinary approach for cancer management.
  
  
  METHODS
  From 01/1995 to 03/2012 IOeRT procedures were registered in a specific Hospital-based database. Research and developments in imaging and recording for treatment planning implementation are active since 2006.
  
  
  RESULTS
  1004 patients were treated and 1036 IORT procedures completed. Median age of patients was 61 (range 5 months to 94 years). Gender distribution was male in 54% of cases and female in 46%. Disease status at the time of IORT was 796 (77%) primary and 240 (23%) recurrent. Cancer type distribution included: 62% gastrointestinal, 18% sarcoma, 5% pancreas, 2% paediatric, 3% breast, 77 7% oligotopic recurrences, 2% other. IORT technical characteristics were: Applicator size 5 cm 22%, 6 cm 21%, 7 cm 21%, 8 cm 15%, 9 cm 6%, 10 cm 7% 12 cm 5% 15 cm 3%. Electron energies: 6 MeV 19%, 8 MeV 15%, 10 MeV 15%, 12 MeV 23%, 15 MeV 19%, 18 MeV 6%, other 3%. Multiple fields: 108 (11%). Dose: 7.5 Gy 3%, 10 Gy 35%, 12 Gy 3%, 12.5 Gy 49%, 15 Gy 5%, other 5%.
  
  
  CONCLUSIONS
  An IORT programme developed in an Academic Hospital based on practice-oriented medical decisions is an attractive interdisciplinary oncology initiative proven to be able to generate an intensive clinical activity for cancer patient quality care and a competitive source of scientific patient-oriented research, development and innovation.
authors: Department of Oncology, Hospital General Universitario Gregorio Marañón, Madrid, Spain ; School of Medicine Complutense University, Madrid, Spain ; Institute for Sanitary Research, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors: Felipe A
authors: FA
authors: Calvo
authors: School of Medicine Complutense University, Madrid, Spain.
authors: Morena
authors: M
authors: Sallabanda
authors: Department of Oncology, Hospital General Universitario Gregorio Marañón, Madrid, Spain ; School of Medicine Complutense University, Madrid, Spain ; Institute for Sanitary Research, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors: Claudio V
authors: CV
authors: Sole
authors: School of Medicine Complutense University, Madrid, Spain ; Service of Radiation Oncology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors: Carmen
authors: C
authors: Gonzalez
authors: School of Medicine Complutense University, Madrid, Spain.
authors: Laura Alonso
authors: LA
authors: Murillo
authors: School of Medicine Complutense University, Madrid, Spain.
authors: Javier
authors: J
authors: Martinez-Villanueva
authors: Service of Radiation Oncology, Hospital General Universitario Gregorio Marañón, Madrid, Spain ; Institute for Sanitary Research, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors: Juan A
authors: JA
authors: Santos
authors: Service of Radiation Oncology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors: Javier
authors: J
authors: Serrano
authors: Service of Radiation Oncology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors: Ana
authors: A
authors: Alavrez
authors: Service of Radiation Oncology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors: Jose
authors: J
authors: Blanco
authors: Service of Radiation Oncology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors: Ana
authors: A
authors: Calin
authors: Service of Radiation Oncology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors: Marina
authors: M
authors: Gomez-Espi
authors: Service of Radiation Oncology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors: Miguel
authors: M
authors: Lozano
authors: Service of Radiation Oncology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors: Rafael
authors: R
authors: Herranz
keywords: Database; Intraoperative radiation therapy; Research