title: Electrospinning of diosmin from aqueous solutions for improved dissolution and oral absorption.
abstract: A nanofibrous membrane carrier for nearly water insoluble drug diosmin was formulated. The aim of this study was to evaluate the drug release and dissolution properties in an aqueous buffer of pH 7.8, and to compare the suitability of the drug carrier with the available drug forms and screen diosmin absorption extent. The membranes were produced from HPC/PVA/PEO-drug water solutions and then evaluated by SEM and DSC measurements. The results showed that diosmin was incorporated within the nanofibers in an amorphous state, and/or as a solid dispersion. The results of in vitro release experiments excerpt a very fast release of the drug, followed by the formation of an over saturated solution and partial precipitation of the drug (a "spring" effect). The enormous increases in dissolution of the drug from a nanofibrous carrier, compared to a micronized and crystalline form, was achieved. The in vivo bioavailability study carried out on rats showed higher initial drug plasma levels and higher AUC values after administration of the nanofibrous drug formulation, compared to the micronized form. The results of the study demonstrated that the improvement of the diosmin in vitro dissolution also brought the enhanced in vivo absorption extent of the drug.
authors: Department of Pharmaceutical Technology, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Czech republic.
authors: Petr
authors: P
authors: Vrbata
authors: Department of Pharmaceutical Technology, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Czech republic.
authors: Pavel
authors: P
authors: Berka
authors: Elmarco Ltd.Co., Liberec, Czech Republic.
authors: Denisa
authors: D
authors: Stránská
authors: Department of Pharmaceutical Technology, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Czech republic. Electronic address: dolezal@faf.cuni.cz.
authors: Pavel
authors: P
authors: Doležal
authors: Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Czech Republic.
authors: Milan
authors: M
authors: Lázníček
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004145:Diosmin / Q000008:administration & dosage / Q000097:blood / Q000737:chemistry* / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D004339:Drug Compounding / Q000379:methods; D005260:Female; D007408:Intestinal Absorption; D008297:Male; D057139:Nanofibers / Q000008:administration & dosage / Q000737:chemistry*; D017208:Rats, Wistar; D012995:Solubility; D012996:Solutions
chemical_list: D004337:Drug Carriers; D012996:Solutions; D004145:Diosmin
keywords: Diosmin; Electrospinning; Nanofibre; Oral bioavailability; Solubility