title: Transplantation-induced cancers: Emerging evidence that clonal CMV-specific NK cells are causal immunogenic factors.
abstract: Solid cancers are a major adverse outcome of liver transplantation. Recent reassessments have revealed insights into causal factors, primarily centering on modulations of the natural killer (NK) cell compartment in liver transplant recipients. In the presence of cytomegalovirus, the clonal expansion of differentiated NK cells could restrict the diversity of the NK repertoire favoring the development of certain tumors.
authors: Sorbonne Universités, UPMC; Univ Paris 06, CR7; CIMI-Paris; Paris, France ; INSERM, U1135; CIMI-Paris; Paris, France ; CNRS, ERL8255; CIMI-Paris; Paris, France.
authors: Abla
authors: A
authors: Achour
authors: Sorbonne Universités, UPMC; Univ Paris 06, CR7; CIMI-Paris; Paris, France ; INSERM, U1135; CIMI-Paris; Paris, France ; CNRS, ERL8255; CIMI-Paris; Paris, France.
authors: Florence
authors: F
authors: Baychelier
authors: AP-HP; Centre des Innovations Thérapeutiques en Oncologie et Hématologie; Hôpital Saint-Louis; Paris, France.
authors: Michel
authors: M
authors: Marty
authors: Sorbonne Universités, UPMC; Univ Paris 06, CR7; CIMI-Paris; Paris, France ; INSERM, U1135; CIMI-Paris; Paris, France ; CNRS, ERL8255; CIMI-Paris; Paris, France.
authors: Patrice
authors: P
authors: Debré
authors: AP-HP; Centre Hépato-biliaire ; Hôpital Paul-Brousse; INSERM UMR-S 785; Villejuif, France.
authors: Didier
authors: D
authors: Samuel
authors: Sorbonne Universités, UPMC; Univ Paris 06, CR7; CIMI-Paris; Paris, France ; INSERM, U1135; CIMI-Paris; Paris, France ; CNRS, ERL8255; CIMI-Paris; Paris, France.
authors: Vincent
authors: V
authors: Vieillard
keywords: cytomegalovirus; de novo cancer; liver transplantation; tumor escape; “clonal” NK cells