title: Ex vivo lung perfusion in clinical lung transplantation--state of the art.
abstract: Ex vivo lung perfusion (EVLP) has emerged as a new technique for assessing and potentially reconditioning human donor lungs previously unacceptable for clinical transplantation with the potential to dramatically push the limits of organ acceptability. With the recent introduction of portable EVLP, a new era in lung preservation may be upon us with the opportunity to also limit organ ischaemic times and potentially improve the outcome of donor lungs already deemed acceptable for transplantation. It took over half a century for the technique to evolve from basic theory to semi-automated circuits fit for clinical use that are now rapidly being adopted in transplant centres across the globe. With this field in constant evolution and many unanswered questions remaining, our review serves as an update on the state of the art of EVLP in clinical lung transplantation.
authors: Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK Cardiopulmonary Transplantation, Institute of Transplantation, Freeman Hospital, Newcastle upon Tyne, UK.
authors: Anders S I
authors: AS
authors: Andreasson
authors: Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK Cardiopulmonary Transplantation, Institute of Transplantation, Freeman Hospital, Newcastle upon Tyne, UK.
authors: John H
authors: JH
authors: Dark
authors: Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK Cardiopulmonary Transplantation, Institute of Transplantation, Freeman Hospital, Newcastle upon Tyne, UK a.j.fisher@ncl.ac.uk.
authors: Andrew J
authors: AJ
authors: Fisher
mesh_terms: D000818:Animals; D006801:Humans; D008168:Lung / Q000098:blood supply / Q000502:physiology / Q000601:surgery*; D016040:Lung Transplantation / Q000379:methods* / Q000639:trends; D010477:Perfusion / Q000295:instrumentation / Q000379:methods / Q000639:trends; D013552:Swine; D014019:Tissue Donors
keywords: Ex vivo lung perfusion; Lung transplantation; State-of-the-art review