title: Stimulated saliva aminotransaminase alteration after experiencing acute hypoxia training.
abstract: OBJECTIVE
  Acute cypobarih hypoxia is generally recognized to be the most serious single physiological hazard during flight at altitude. Simulation of acute hypoxia in an altitude chamber is used for the training of military aircrew. Acute hypobaric hypoxia affects critical organ systems in different manners. The purpose of this study was to investigate stimulated saliva glutamic pyruvic transaminase (GPT) and glutamic oxaloacetic transaminase (GOT) alteration after the hypobaric hypoxia process.
  
  
  METHODS
  A cross-sectional study was performed in 44 normal healthy military aircrew conducted at the hypobaric chamber of physiology at the University of Medical Sciences, Tehran, Iran. The GPT and GOT activities were assayed in stimulated whole saliva before and after the experience of hypobaric hypoxia by the International Federation of Clinical Chemistry method. Statistical analysis of the Student t-test was performed.
  
  
  RESULTS
  The mean stimulated saliva GPT activity was significantly higher after the experience of the hypobaric hypoxia process (2.83 ± 0.34 vs. 0.42 ± 0.029 U/L, respectively; P = .001). Saliva GOT activity was also increased after this process (3.32 ± 0.43 vs. 1.22 ± 0.18 U/L, respectively; P = .001).
  
  
  CONCLUSIONS
  Results suggest that subsequent to the experience of the hypobaric hypoxia process, there is a rise in the salivary activities of aminotransferases.
authors: Department of Physiology, School of Medicine, Aja University of Medical Sciences in Tehran, Iran.
authors: Mahmud
authors: M
authors: Mominzadeh
authors: Department of Physiology, School of Medicine, Aja University of Medical Sciences in Tehran, Iran.
authors: Iraj
authors: I
authors: Mirzaii-Dizgah
authors: School of Medicine, Iran University of Medical Sciences in Tehran, Iran.
authors: Mohammad-Reza
authors: MR
authors: Mirzaii-Dizgah
authors: School of Dentistry, Aja University of Medical Sciences in Tehran, Iran. Electronic address: rmirzaii@razi.tums.ac.ie.
authors: Mohammad-Hossein
authors: MH
authors: Mirzaii-Dizgah
mesh_terms: D000328:Adult; D000399:Air Pressure; D000410:Alanine Transaminase / Q000378:metabolism*; D000531:Altitude; D001219:Aspartate Aminotransferases / Q000378:metabolism*; D003430:Cross-Sectional Studies; D006801:Humans; D000860:Hypoxia / Q000201:enzymology*; D007492:Iran; D008297:Male; D008889:Military Personnel; D012463:Saliva / Q000201:enzymology*; D055815:Young Adult
chemical_list: D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase