title: Evaluation of corneal deformation analyzed with Scheimpflug based device in healthy eyes and diseased ones.
abstract: This study was designed to evaluate the correlation between corneal biomechanical and morphological data in healthy eyes, eyes that underwent myopic photorefractive keratectomy (PRK), keratoconus affected eyes, and keratoconus affected eyes that underwent corneal collagen crosslinking (CCC). Complete clinical eye examination of all eyes was followed by tomographic (Pentacam, Oculus, Wetzlar, Germany) and biomechanical (Corvis ST, Oculus, Wetzlar, Germany) evaluation. Differences among Corvis ST (CST) parameters in the different groups have been performed. Linear regression between central corneal thickness (CCT), intraocular pressure (IOP), and anterior corneal curvature measured with Sim'K (KM), versus corneal deformation parameters measured with Corvis ST in the different groups, has been run using SPSS software version 18.0. We evaluated 64 healthy eyes of 64 patients with a mean refractive error of -0.65 ± 1.68 D (measured as spherical equivalent), 17 eyes of 17 patients that underwent myopic PRK for a mean refractive defect of -4.91 ± 2.05 D (measured as spherical equivalent), 16 eyes of 16 patients affected by keratconus (stage 2-3 of Amsler Classification), and 13 eyes of 13 patients affected by keratoconus that underwent CCC. Our data suggest that corneal curvature would have a greater influence on corneal deformation than CCT; in fact KM values are more strongly associated with more CST parameters both about corneal change in shape and both about the corneal ability to come back at original shape.
authors: Multidisciplinary Department of Medical, Surgical and Dental Sciences, Second University of Naples, Via De Crecchio 16, 80100 Napoli, Italy ; Centro Grandi Apparecchiature, Second University of Naples, Via De Crecchio 16, 80100 Napoli, Italy.
authors: Michele
authors: M
authors: Lanza
authors: Centro Grandi Apparecchiature, Second University of Naples, Via De Crecchio 16, 80100 Napoli, Italy.
authors: Michela
authors: M
authors: Cennamo
authors: Centro Grandi Apparecchiature, Second University of Naples, Via De Crecchio 16, 80100 Napoli, Italy.
authors: Stefania
authors: S
authors: Iaccarino
authors: Centro Grandi Apparecchiature, Second University of Naples, Via De Crecchio 16, 80100 Napoli, Italy.
authors: Carlo
authors: C
authors: Irregolare
authors: Santa Lucia Eye Clinic, Via Trieste 71, 00198 Cosenza, Italy.
authors: Miguel
authors: 0000-0002-1016-2535
authors: M
authors: Rechichi
authors: Multidisciplinary Department of Medical, Surgical and Dental Sciences, Second University of Naples, Via De Crecchio 16, 80100 Napoli, Italy.
authors: Mario
authors: M
authors: Bifani
authors: Multidisciplinary Department of Medical, Surgical and Dental Sciences, Second University of Naples, Via De Crecchio 16, 80100 Napoli, Italy.
authors: Ugo Antonello
authors: UA
authors: Gironi Carnevale
mesh_terms: D000328:Adult; D001696:Biomechanical Phenomena; D003094:Collagen / Q000737:chemistry; D003315:Cornea / Q000503:physiopathology*; D005123:Eye / Q000378:metabolism; D005260:Female; D006801:Humans; D007429:Intraocular Pressure; D007640:Keratoconus / Q000175:diagnosis / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000503:physiopathology*; D018903:Photorefractive Keratectomy / Q000379:methods*; D012030:Refractive Errors; D015203:Reproducibility of Results; D014054:Tomography / Q000379:methods*; D014065:Tonometry, Ocular / Q000295:instrumentation / Q000379:methods*
chemical_list: D003094:Collagen