title: Elevated odds of metabolic syndrome in psoriasis: a population-based study of age and sex differences.
abstract: BACKGROUND
  Questions remain concerning to what extent age and sex may modify the suggested association between psoriasis and the metabolic syndrome in the general population.
  
  
  OBJECTIVE
  To investigate the association between psoriasis and the metabolic syndrome within a large population-based cohort by age and sex.
  
  
  METHODS
  A cross-sectional study including 10 521 participants aged 30-79 years from the Tromsø Study cohort was performed; 1137 participants reported lifetime psoriasis of a mainly mild character. The new harmonized definition of metabolic syndrome was used in the multivariable logistic regression analysis.
  
  
  RESULTS
  There was a uniformly higher prevalence of metabolic syndrome in men and women with psoriasis compared with those without across all age groups. In women, psoriasis was associated with a 3·8-times higher odds of metabolic syndrome at age 30 years (95% confidence interval 1·5-9·7), with a decreasing odds ratio with increasing age. In men, psoriasis was associated with a stable 1·35-times higher odds of metabolic syndrome (95% confidence interval 1·1-1·6) at all ages. Abdominal obesity was the most frequent metabolic syndrome component in women in this study, and there was indication of a dose-response relationship between psoriasis severity, indicated through treatment, and having a high waistline in women.
  
  
  CONCLUSIONS
  This study suggests age and sex variations in the risk of metabolic syndrome among individuals with psoriasis. Given the high prevalence of psoriasis and the significantly elevated burden of metabolic syndrome in this patient group, there may be a benefit from targeted screening of metabolic syndrome among individuals with psoriasis regardless of age and disease severity.
authors: Department of Dermatology, Neuro and Orthopaedic Clinic, University Hospital of North Norway, Tromsø, Norway; Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway.
authors: K
authors: K
authors: Danielsen
authors: T
authors: T
authors: Wilsgaard
authors: A O
authors: AO
authors: Olsen
authors: A E
authors: AE
authors: Eggen
authors: K
authors: K
authors: Olsen
authors: P A
authors: PA
authors: Cassano
authors: A-S
authors: AS
authors: Furberg
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000453:epidemiology; D008875:Middle Aged; D009664:Norway / Q000453:epidemiology; D015995:Prevalence; D011565:Psoriasis / Q000150:complications* / Q000453:epidemiology; D012307:Risk Factors; D017678:Sex Distribution