title: Flow-regulated lymphatic vasculature development and signaling.
abstract: The role of blood flow in regulating signaling pathways and gene expression in the blood vasculature is well known. Recent studies have identified equally important roles of flow-mediated signaling in the lymphatic circulation including control of lymphatic vascular growth, remodeling, regeneration and maintenance of the lymphatic fate. In this review, we summarize these advances focusing on the role of fluid dynamics in control of lymphatic vasculature formation.
authors: Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, 300 George St, New Haven, CT 06520, USA.
authors: Yingdi
authors: Y
authors: Wang
authors: Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, 300 George St, New Haven, CT 06520, USA ; Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA.
authors: Michael
authors: M
authors: Simons
keywords: Flow; Lymphatic endothelial cells; Lymphatic vascular development; Shear stress; Signaling