title: The microbiome modulates the tumor macroenvironment.
abstract: Earlier investigations of the tumor microenvironment unveiled systemic networks presenting novel therapeutic opportunities. It has been recently shown that gut microbes modulate whole host immune and neuroendocrine factors impacting the fate of distant preneoplastic lesions toward malignancy or regression. These findings establish a new paradigm of holobiont therapeutic engineering in emerging tumor macroenvironments.
authors: Division of Comparative Medicine; Massachusetts Institute of Technology; Cambridge, MA USA.
authors: Susan E
authors: SE
authors: Erdman
authors: Division of Comparative Medicine; Massachusetts Institute of Technology; Cambridge, MA USA ; Laboratory of Pathology; Faculty of Veterinary Medicine; Aristotle University of Thessaloniki; Thessaloniki, Greece.
authors: Theofilos
authors: T
authors: Poutahidis
keywords: beneficial microbes; carcinogenesis; microbiome; regulatory T cells; tumor macroenvironment