title: A tertiary sulfonium compound, dimethylsulfoniopropionate in green sea algae, completely suppresses crucial Ehrlich ascites carcinoma in mice.
abstract: OBJECTIVE
  Dimethylsulfoniopropionate (DMSP) has been intensively studied in bacteria, plankton, algae and salt-resistant plants to investigate its metabolism and fate in the atmosphere. However, its effects on diseased terrestrial animals have not yet been examined. We have found that DMSP exerts a great healing effect for a variety of inflammatory disorders in rodents. In the present study, effects of single and high concentration of DMSP on terrible Ehrlich ascites carcinoma (EAC) bearing-mice with unavoidable-rapid death were examined.
  
  
  RESULTS
  We found that high concentration of DMSP completely suppresses acute EAC, which has never been eradicated, and accumulates large amounts of activated macrophages with no inflammation on various viscera in the peritoneal cavity of normal mice.
  
  
  CONCLUSIONS
  These results show that DMSP is a new and potent anticancer compound with no side-effects, most likely playing a vital role for cancer immune therapy.
authors: Department of Nutrition, Faculty of Nutrition, Graduate School of Koshien University, Takarazuka, Hyogo, Japan fantasista999@gmail.com.
authors: Kenji
authors: K
authors: Nakajima
authors: Department of Nutrition, Faculty of Nutrition, Graduate School of Koshien University, Takarazuka, Hyogo, Japan.
authors: Satomi
authors: S
authors: Tsujiwaki
authors: Department of Biology, Faculty of Science, Graduate School of Okayama University, Okayama, Japan.
authors: Yoshiki
authors: Y
authors: Nakajima
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001835:Body Weight / Q000187:drug effects; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D000460:Chlorophyta / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D008264:Macrophages / Q000502:physiology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D013452:Sulfonium Compounds / Q000627:therapeutic use*; D013864:Thioglycolates / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D013452:Sulfonium Compounds; D013864:Thioglycolates; C017487:2-mercaptoacetate; C068078:dimethylpropiothetin
keywords: Ehrlich ascites carcinoma; anti-cancer effects; ascites fluid; dimethylsulfoniopropionate; toxicity