title: Case for diagnosis.
abstract: We report the case of a 81-year-old female patient who had a two-year history of violet-colored erythematous tumors on both legs. Histopathological and immunohistochemical examinations confirmed the diagnosis of primary cutaneous large B-cell lymphoma, leg type. This rare, cutaneous lymphoma affects predominantly elderly females. Clinically, patients present with tumoral lesions on one or both legs (worst prognosis). Diagnosis is based on clinical, histopathological and immunohistochemical findings. The strong expression of BCL2, BCL6, MUM-1 and CD20, and the positivity for Ki67 antigen confirm the diagnosis. R-CHOP chemotherapy regimen (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone) is the most widely accepted treatment.
authors: Alfredo da Matta Foundation, Manaus, AM, Brazil.
authors: Gustavo Ávila
authors: GÁ
authors: Maquiné
authors: Alfredo da Matta Foundation, Manaus, AM, Brazil.
authors: Maria de Fátima
authors: Mde F
authors: Maroja
authors: Santa Júlia Hospital, Manaus, AM, Brazil.
authors: Cristina Rabello
authors: CR
authors: Mesquita
authors: Alfredo da Matta Foundation, Manaus, AM, Brazil.
authors: Petra Pereira de
authors: PP
authors: Sousa
authors: Alfredo da Matta Foundation, Manaus, AM, Brazil.
authors: Patrícia Motta de
authors: PM
authors: Morais
authors: Alfredo da Matta Foundation, Manaus, AM, Brazil.
authors: Carolina
authors: C
authors: Talhari
mesh_terms: D000369:Aged, 80 and over; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007866:Leg; D016393:Lymphoma, B-Cell / Q000188:drug therapy / Q000473:pathology*; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology*; D016896:Treatment Outcome