title: Influence of anthropometric measurements on abnormal gonadotropin secretion in women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To evaluate the influence of anthropometric measurements on abnormal gonadotropin secretion in patients with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  The Institute of Basic Medical Sciences (IBMS), DUHS in collaboration with Gynae/infertility clinics of the Civil Hospital and Lady Dufferin Hospital, Karachi, from October 2010 to February 2011.
  
  
  METHODS
  One hundred and sixty three oligomenorrhic PCOS women of reproductive age (18 - 40 years) fulfilling the revised Rotterdam 2003 criteria were studied. The data recorded on a prescribed proforma included current age, age at menarche, menstrual irregularities, presence of hirsuitism, acne, infertility, familial nature, blood pressure, BMI and waist-hip ratio. Blood samples for gonadotropin assay were taken randomly on day 6th to 30th of menstrual cycle, in a gel tube. Hormonal assay was performed using chemiluminescent immunoassay. Kruskul Wallis test was used to assess the influence of BMI levels on LH:FSH values.
  
  
  RESULTS
  The mean weight was 66.14 ± 11.02 kg and mean BMI was 27.03 ± 4.42 kg/m2. There was no significant difference in mean LH/FSH ratio (p=.575) among BMI groups. However, there was a positive correlation between BMI and LH:FSH ratio (p=0.04, r=0.155).
  
  
  CONCLUSIONS
  There was high frequency of obesity (69%) in women with PCOS. Although no significant difference was found between mean LH:FSH ratio among different BMI groups levels but significant correlation between BMI levels and LH: FSH suggested that there was positive relation between BMI and LH: FSH.
authors: Department of Physiology, Dow University of Health Sciences (DUHS), Karachi.
authors: Shehla
authors: S
authors: Haider
authors: Department of Physiology, Dow University of Health Sciences (DUHS), Karachi.
authors: Nighat
authors: N
authors: Mannan
authors: Department of Obstetrics and Gynaecology, Dow University of Health Sciences (DUHS), Karachi.
authors: Ayesha
authors: A
authors: Khan
authors: Department of Physiology, Dow University of Health Sciences (DUHS), Karachi.
authors: Masood A
authors: MA
authors: Qureshi
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006062:Gonadotropins / Q000097:blood*; D006801:Humans; D008163:Luminescent Measurements; D007986:Luteinizing Hormone / Q000097:blood*; D010154:Pakistan; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D018709:Statistics, Nonparametric; D049629:Waist-Hip Ratio; D055815:Young Adult
chemical_list: D006062:Gonadotropins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone