title: Molecular targeted α-particle therapy for oncologic applications.
abstract: OBJECTIVE
  A significant challenge facing traditional cancer therapies is their propensity to significantly harm normal tissue. The recent clinical success of targeting therapies by attaching them to antibodies that are specific to tumor-restricted biomarkers marks a new era of cancer treatments.
  
  
  CONCLUSIONS
  In this article, we highlight the recent developments in α-particle therapy that have enabled investigators to exploit this highly potent form of therapy by targeting tumor-restricted molecular biomarkers.
authors: 1 Department of Radiology, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157.
authors: Thaddeus J
authors: TJ
authors: Wadas
authors: Darpan N
authors: DN
authors: Pandya
authors: Kiran Kumar
authors: KK
authors: Solingapuram Sai
authors: Akiva
authors: A
authors: Mintz
mesh_terms: D000512:Alpha Particles / Q000627:therapeutic use*; D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000032:analysis; D016503:Drug Delivery Systems; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D009369:Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D019275:Radiopharmaceuticals / Q000627:therapeutic use*; D011879:Radiotherapy Dosage
chemical_list: D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D019275:Radiopharmaceuticals
keywords: 213Bi; 223Ra; 225Ac; molecular radiotherapy; nuclear medicine; radioimmunotherapy; α-particle therapy