title: Design and fabrication of biological wires.
abstract: Cardiac tissue engineering using human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) has facilitated the creation of in vitro diagnostic platforms to study novel small molecules and cardiac disease at the tissue level. Yet, due to the immaturity of hPSC-CMs, there is a low fidelity between tissue-engineered cardiac tissues and adult cardiac tissues. To address this challenge, we have developed a platform that combines both physical and electrical cues to guide hPSC-CMs towards a more mature state in vitro.
authors: Institute of Biomaterials and Biomedical Engineering, Department of Chemical Engineering and Applied Chemistry, University of Toronto, 164 College Street, Room 407, Toronto, ON, Canada, M5S 3G9.
authors: Jason W
authors: JW
authors: Miklas
authors: Sara S
authors: SS
authors: Nunes
authors: Boyang
authors: B
authors: Zhang
authors: Milica
authors: M
authors: Radisic
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002469:Cell Separation; D024042:Collagen Type I / Q000494:pharmacology; D003584:Cytological Techniques / Q000295:instrumentation*; D004129:Dimethylpolysiloxanes / Q000494:pharmacology; D004558:Electric Stimulation; D004867:Equipment Design; D006801:Humans; D032383:Myocytes, Cardiac / Q000166:cytology; D039904:Pluripotent Stem Cells / Q000166:cytology* / Q000187:drug effects; D051381:Rats; D023822:Tissue Engineering
chemical_list: D024042:Collagen Type I; D004129:Dimethylpolysiloxanes; C013830:baysilon