title: LeA(H)Rning self-control.
abstract: The aryl hydrocarbon receptor (AhR) is an important regulator of the immune response. A report by Puccetti and coworkers describes a regulatory pathway by which L-kynurenine (L-Kyn) produced by tryptophan 2,3-dioxygenase 2 (TDO2) activates AhR in cells of the innate immune system to limit endotoxin-triggered inflammation through a mechanism that involves the non-enzymatic anti-inflammatory activities of indoleamine 2,3-dioxygenase 1 (IDO1).
authors: Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
authors: Francisco J
authors: FJ
authors: Quintana
mesh_terms: D000818:Animals; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology*; D018336:Receptors, Aryl Hydrocarbon / Q000378:metabolism*; D012772:Shock, Septic / Q000139:chemically induced*
chemical_list: D008070:Lipopolysaccharides; D018336:Receptors, Aryl Hydrocarbon