title: Neuroprotective Xanthones from the Root Bark of Cudrania tricuspidata.
abstract: Seventeen new prenylated xanthones (1-17) were isolated from an ethyl acetate-soluble extract of root bark of Cudrania tricuspidata together with 17 previously identified xanthones. The structures of the new compounds were elucidated by spectroscopic methods. Six new compounds (3, 7, 8, 9, 15, and 16) and six known compounds (18-23) showed neuroprotective effects against 6-hydroxydopamine-induced cell death in human neuroblastoma SH-SY5Y cells, with EC50 values of 0.7-16.6 μM.
authors: Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology, Korea University , Seoul 136-713, Korea.
authors: Jaeyoung
authors: J
authors: Kwon
authors: Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology, Korea University , Seoul 136-713, Korea.
authors: Nguyen Tuan
authors: NT
authors: Hiep
authors: Natural Products Research Institute, College of Pharmacy, Seoul National University , Seoul 151-742, Korea.
authors: Dong-Woo
authors: DW
authors: Kim
authors: College of Pharmacy, Chungbuk National University , Cheongju 361-763, Korea.
authors: Bang Yeon
authors: BY
authors: Hwang
authors: Korea Forest Research Institute , Seoul 130-712, Korea.
authors: Hak Ju
authors: HJ
authors: Lee
authors: Natural Products Research Institute, College of Pharmacy, Seoul National University , Seoul 151-742, Korea.
authors: Woongchon
authors: W
authors: Mar
authors: Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology, Korea University , Seoul 136-713, Korea.
authors: Dongho
authors: D
authors: Lee
mesh_terms: D016923:Cell Death / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D029586:Moraceae / Q000737:chemistry*; D009447:Neuroblastoma / Q000139:chemically induced / Q000188:drug therapy; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019906:Nuclear Magnetic Resonance, Biomolecular; D016627:Oxidopamine / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D056910:Republic of Korea; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D018696:Neuroprotective Agents; D044004:Xanthones; C000602014:cudratrixanthone A; D016627:Oxidopamine