title: Design of liposomal colloidal systems for ocular delivery of ciprofloxacin.
abstract: Ophthalmic drug bioavailability is limited due to protective mechanisms of the eye which require the design of a system to enhance ocular delivery. In this study several liposomal formulations containing ciprofloxacin (CPX) have been formulated using reverse phase evaporation technique with final dispersion of pH 7.4. Different types of phospholipids including Phosphatidylcholine, Dipalmitoylphosphatidylcholine and Dimyristoyl-sn-glycero-3-phosphocholine were utilized. The effect of formulation factors such as type of phospholipid, cholesterol content, incorporation of positively charging inducing agents and ultrasonication on the properties of the liposomal vesicles was studied. Bioavailability of selected liposomal formulations in rabbit eye aqueous humor has been investigated and compared with that of commercially available CPX eye drops (Ciprocin®). Pharmacokinetic parameters including Cmax, Tmax, elimination rate constant, t1/2, MRT and AUC0-∞, were determined. The investigated formulations showed more than three folds of improvement in CPX ocular bioavailability compared with the commercial product.
authors: College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
authors: Ehab I
authors: EI
authors: Taha
authors: College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
authors: Magda H
authors: MH
authors: El-Anazi
authors: Department of Pharmaceutics, College of Pharmacy, Al-Jouf University, P.O. Box 2014, Al-Jouf, Sakaka, Saudi Arabia.
authors: Ibrahim M
authors: IM
authors: El-Bagory
authors: College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
authors: Mohsen A
authors: MA
authors: Bayomi
keywords: Bioavailability; Cholesterol; Entrapment efficiency; Ophthalmic; Particle size; Pharmacokinetics; Phospholipid; Rabbit