title: Drug reaction with eosinophilia and systemic symptoms during primary Epstein-Barr virus infection.
abstract: We report a drug reaction with eosinophilia and systemic symptoms case of primary Epstein-Barr virus (EBV) infection, in which the diagnosis was first confirmed by lymphocyte transformation tests (LTT). LTTs were positive for cefditoren-pivoxil and acetaminophen. LTT, EBV load, and anti-EBV antibodies could allow early diagnosis of drug reaction with eosinophilia and systemic symptoms, which masquerades with the clinical features of infectious mononucleosis.
authors: Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors: Etsuro
authors: E
authors: Nanishi
authors: Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Pediatrics, University of Occupational and Environmental Health, Kitakyushu, Japan. Electronic address: hoshina@pediatr.med.kyushu-u.ac.jp.
authors: Takayuki
authors: T
authors: Hoshina
authors: Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors: Shouichi
authors: S
authors: Ohga
authors: Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors: Hisanori
authors: H
authors: Nishio
authors: Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors: Toshiro
authors: T
authors: Hara
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects* / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D058633:Antipyretics / Q000009:adverse effects* / Q000627:therapeutic use; D002511:Cephalosporins / Q000009:adverse effects* / Q000627:therapeutic use; D002675:Child, Preschool; D063926:Drug Hypersensitivity Syndrome / Q000175:diagnosis* / Q000473:pathology; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D008297:Male
chemical_list: D000900:Anti-Bacterial Agents; D058633:Antipyretics; D002511:Cephalosporins; D000082:Acetaminophen; C057710:cefditoren pivoxil
keywords: Epstein–Barr virus; acetaminophen; cefditoren–pivoxil; drug reaction with eosinophilia and systemic symptoms; lymphocyte transformation test