title: Comparative analysis of human mitochondrial methylomes shows distinct patterns of epigenetic regulation in mitochondria.
abstract: DNA methylation and histone modifications across the nuclear genome have been extensively analyzed, but the epigenetic modifications associated with the mitochondrial genome have not yet been analyzed at high resolutions. In the present work, we analyzed methyl-cytosine profiles from methylated DNA immunoprecipitation datasets from 39 different human cell and tissue types from the NIH Roadmap Epigenomics project and validated the data using an orthologous bisulfite sequencing dataset. We observe a distinct distribution of zmethyl-cytosine in mitochondrial genomes which are conserved across all cell and tissue types. This study thus describes the first comprehensive map of methyl cytosines across the human mitochondrial genome.
authors: Genomics and Molecular Medicine, CSIR Institute of Genomics and Integrative Biology, Mall Road, Delhi 110007, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi, India.
authors: Sourav
authors: S
authors: Ghosh
authors: Genomics and Molecular Medicine, CSIR Institute of Genomics and Integrative Biology, Mall Road, Delhi 110007, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi, India. Electronic address: shantanus@igib.res.in.
authors: Shantanu
authors: S
authors: Sengupta
authors: GN Ramachandran Knowledge Center for Genome Informatics, CSIR Institute of Genomics and Integrative Biology, Mall Road, Delhi 110007, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi, India. Electronic address: vinods@igib.in.
authors: Vinod
authors: V
authors: Scaria
mesh_terms: D044503:5-Methylcytosine / Q000032:analysis*; D004247:DNA / Q000737:chemistry*; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D006801:Humans; D008928:Mitochondria / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*
chemical_list: D044503:5-Methylcytosine; D004247:DNA
keywords: DNA methylation; Epigenome; Methylome; Mitochondria; Tissue