title: Initial experience of the use of photodynamic therapy (PDT) in recurrent malignant and pre-malignant lesions of the vulva.
abstract: OBJECTIVE
  To assess the suitability and effectiveness of photodynamic therapy (PDT) in the treatment and symptom relief of vulval intraepithelial neoplasia (VIN), other pre-malignant and early neoplastic conditions of the vulva in an out patient setting.
  
  
  METHODS
  Patients were selected from the vulvoscopy clinic whilst being investigated or under long-term follow-up. PDT was offered to patients in whom other treatments had failed or were unsuitable. 5-Aminoleuvinic acid (5-ALA) was used as a topical pro-drug, inducing the photosensitiser protoporphyrin IX. This was applied 4-6h before treatment. Laser light (630nm) generated by a Diode laser and Light Emitting Diode (LED) non-laser light of 630nm wavelength was also used. Initially, PDT was carried out with no analgesia, followed by oral analgesia, inhaled nitrous oxide and oral anxiolytic. Patients were seen and examined 2-3 weeks following treatment to assess clinical and symptomatic improvement. Further review was arranged as required.
  
  
  RESULTS
  All those who had been symptomatic described improvement of their symptoms and all improved clinically. However, pain was a significant side effect during treatment and for 24h post treatment in most cases.
  
  
  CONCLUSIONS
  The use of PDT for pre-malignant and early malignant vulval conditions, particularly VIN appears to be effective in the control of symptoms and can be carried out in an outpatient setting. However, a further long-term study, combined with biopsy, is needed to assess the pathological response. Pain is a significant side effect.
authors: Department of MRI, Hull Royal Infirmary, Anlaby Road, Hull, East Yorkshire HU3 2JZ, United Kingdom.
authors: Susanne
authors: S
authors: Booth
authors: Department of Gynaecology, Castle Hill Hospital, Cottingham, Hull, East Yorkshire HU16 5JQ, United Kingdom.
authors: David
authors: D
authors: Poole
authors: Yorkshire Laser Centre, Goole and District Hospital, Woodland Avenue, Goole, East Yorkshire DN14 6RX, United Kingdom.
authors: Keyvan
authors: K
authors: Moghissi