title: Efficacy of topical recombinant human platelet-derived growth factor for treatment of diabetic lower-extremity ulcers: Systematic review and meta-analysis.
abstract: OBJECTIVE
  Recombinant human platelet-derived growth factor (rhPDGF) is used topically in the treatment of diabetic lower-extremity ulcers. There have been few meta-analyses of the efficacy of rhPDGF in this treatment context. The aim of this study was to perform an updated systematic review and meta-analysis to assess the clinical efficacy of rhPDGF in the treatment of diabetic lower-extremity ulcers.
  
  
  METHODS
  We searched the MEDLINE, Cochrane Library, EMBASE and Web of Knowledge databases up to April 30, 2014. Studies were identified and selected, and data were extracted by two independent reviewers. The primary efficacy outcome was complete healing rate. Adverse events were also assessed. The studies were evaluated for quality and publication bias.
  
  
  RESULTS
  A total of 6 randomized controlled trials including 992 patients were selected from 173 identified studies. The studies compared rhPDGF treatment in the context of standard of care (SOC) to placebo or SOC alone. In the absence of study heterogeneity, a fixed-effects model was performed, and the combined odds ratio (OR) indicated a significantly greater complete healing rate in patients treated with rhPDGF compared to placebo or SOC alone. The ORs ranged from 0.58 to 2.77, with a combined OR of 1.53 (95% CI = 1.14 to 2.04, p = 0.004). A sensitivity analysis (leave-one-out method) indicated good study reliability, and a funnel plot with Egger test showed no publication bias.
  
  
  CONCLUSIONS
  These results indicate that rhPDGF is efficacious in the treatment of diabetic lower-extremity ulcers.
authors: Department of Geriatrics, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.
authors: Xiao-hong
authors: XH
authors: Zhao
authors: Department of Geriatrics, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.
authors: Hai-feng
authors: HF
authors: Gu
authors: Department of Geriatrics, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.
authors: Zhe-rong
authors: ZR
authors: Xu
authors: Department of Geriatrics, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.
authors: Qin
authors: Q
authors: Zhang
authors: Department of Geriatrics, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.
authors: Xue-ying
authors: XY
authors: Lv
authors: Department of Geriatrics, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.
authors: Xiao-jun
authors: XJ
authors: Zheng
authors: Department of Geriatrics, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China. Electronic address: jdfox@aliyun.com.
authors: Yun-mei
authors: YM
authors: Yang
mesh_terms: D000287:Administration, Topical; D048909:Diabetes Complications / Q000188:drug therapy*; D005260:Female; D016523:Foot Ulcer / Q000188:drug therapy*; D006801:Humans; D035002:Lower Extremity; D008297:Male; D008875:Middle Aged; D010982:Platelet-Derived Growth Factor / Q000009:adverse effects / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D011994:Recombinant Proteins / Q000009:adverse effects / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D010982:Platelet-Derived Growth Factor; D011994:Recombinant Proteins
keywords: Diabetes; Diabetic foot ulcer; Platelet-derived growth factor; Wound healing