title: Live Related versus Cadaveric Limbal Allograft in Limbal Stem Cell Deficiency.
abstract: OBJECTIVE
  To compare outcomes of live related limbal allograft (Lr-CLAL) versus cadaveric keratolimbal allograft (KLAL) in limbal stem cell deficiency (LSCD) secondary to ocular burns.
  
  
  METHODS
  Twenty patients with stage IIb LSCD were randomized so that cases underwent either Lr-CLAL or KLAL. Fibrovascular pannus was removed and superficial keratectomy done on the recipient bed. Limbal lenticule of 2-3 clock hours' length was harvested from the donor, which was placed over the host bed and sutured followed by bandage contact lens application. Parameters assessed were uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA), conjunctivalization, corneal neovascularization, epithelial defects, corneal clarity, Schirmer's test, tear film breakup time (tBUT), and ultrasonic pachymetry.
  
  
  RESULTS
  At 6 months follow-up, the Lr-CLAL group had a higher gain in vision (p = 0.029), decrease in conjunctivalization (p = 0.009), and increase in Schirmer's values (p = 0.009).
  
  
  CONCLUSIONS
  Lr-CLAL seems to have better result in terms of vision gain and ocular surface restoration.
authors: Cornea & Refractive Surgery Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences , New Delhi , India and.
authors: Jeewan S
authors: JS
authors: Titiyal
authors: Namrata
authors: N
authors: Sharma
authors: Ashish K
authors: AK
authors: Agarwal
authors: Gaurav
authors: G
authors: Prakash
authors: Radhika
authors: R
authors: Tandon
authors: Rasik
authors: R
authors: Vajpayee
mesh_terms: D000293:Adolescent; D003316:Corneal Diseases / Q000473:pathology / Q000601:surgery*; D016039:Corneal Transplantation / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016850:Limbus Corneae / Q000473:pathology*; D019520:Living Donors; D008297:Male; D011446:Prospective Studies; D012189:Retrospective Studies; D013997:Time Factors; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D014792:Visual Acuity
keywords: Cadaveric keratolimbal allograft; limbal stem cell deficiency; limbal stem cell transplantation; live related allograft