title: Multivalent inhibitors for carbohydrate-processing enzymes: beyond the "lock-and-key" concept.
abstract: During the last decades, tremendous chemical efforts have been dedicated to design monovalent inhibitors of carbohydrate-processing enzymes, with comparatively few rewards in terms of marketed drugs. Recently, an alternative to the traditional "lock and key" approach has emerged. Multivalency, a widely used strategy for lectin inhibition, has been successfully applied to specific glycosidases and glycosyltransferases.
authors: LUNAM Université, CEISAM, Chimie Et Interdisciplinarité, Synthèse, Analyse, Modélisation, UMR CNRS 6230, UFR des Sciences et des Techniques, 2 rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3 (France), Fax: (+33) 2-51-12-57-12. sebastien.gouin@univ-nantes.fr.
authors: Sébastien G
authors: SG
authors: Gouin
mesh_terms: D000818:Animals; D050260:Carbohydrate Metabolism; D002241:Carbohydrates / Q000737:chemistry*; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D009439:Neuraminidase / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D013329:Structure-Activity Relationship; D043323:alpha-Mannosidase / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism
chemical_list: D002241:Carbohydrates; D004791:Enzyme Inhibitors; D006026:Glycoside Hydrolases; D009439:Neuraminidase; D043323:alpha-Mannosidase
keywords: carbohydrates; drug design; enzymes; inhibitors