title: Comparative Study of Three Traditional Mongolian Medicines on Streptozotocin-induced Diabetic Nephropathy in Rats.
abstract: 3 kinds of prescription of Traditional Mongolian (Chinese) Medicine (TMM) have been used in treating diabetic nephropathy (DN). We aimed to investigate: first, which prescription was more effective; second, whether it was more effective when combined with the 3 prescriptions. The DN model was prepared by a single dose of Streptozotocin (STZ, 65 mg/kg, i.p.) in rats and treated 3 times every day with P-1 (Sugmul-10), P-2 (Narenmandul-11), P-3 (Xieriga-4) respectively, and combined group was treated with P-1 in the morning, P-2 and P-3 in the evening. The results showed combining with 3 prescriptions in one day was much more effective than each single prescription. The mechanism of renal protection maybe related to MMP-2 and TGF-β1, the conclusion could be useful and beneficial for clinical medicine.
authors: Inner Mongolia National University of Mongolia Medical College, Tong liao, Inner Mongolia, P.R. China.
authors: X-L
authors: XL
authors: Wang
authors: Inner Mongolia National University of Mongolia Medical College, Tong liao, Inner Mongolia, P.R. China.
authors: A
authors: A
authors: Liji
authors: Medicinal Chemistry and Pharmacology Institute, Inner Mongolia University for the Nationalities, Tongliao, P.R. China.
authors: J
authors: J
authors: Liu
authors: Medicinal Chemistry and Pharmacology Institute, Inner Mongolia University for the Nationalities, Tongliao, P.R. China.
authors: X-Z
authors: XZ
authors: Wang
authors: Medicinal Chemistry and Pharmacology Institute, Inner Mongolia University for the Nationalities, Tongliao, P.R. China.
authors: C-X
authors: CX
authors: Wei
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced* / Q000188:drug therapy* / Q000378:metabolism; D003928:Diabetic Nephropathies / Q000139:chemically induced* / Q000188:drug therapy / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D056785:Medicine, Mongolian Traditional / Q000379:methods; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin / Q000494:pharmacology*; D053773:Transforming Growth Factor beta1 / Q000378:metabolism
chemical_list: D004365:Drugs, Chinese Herbal; D053773:Transforming Growth Factor beta1; D013311:Streptozocin; D020778:Matrix Metalloproteinase 2