title: ABL1 gene involvement within a complex three-way translocation (2;9;4) in perineurioma characterized by molecular cytogenetic methods.
abstract: Perineuriomas are rare peripheral nerve sheath tumors with one or few chromosomal rearrangements or numerical changes. Two main types and three subtypes have been defined but with few specific genetic associations. Chromosome 10 aberrations have been found in three cases of the sclerosing perineurioma subtype. Chromosome 22 abnormalities have been described in different types of perineurioma. None of these aberrations has been described at the molecular level. We report on a complex rearrangement characterized by fluorescence in situ hybridization and array-comparative genome hybridization, which revealed submicroscopic deletions at 2p23 and 9q34 that involved the ABL1 gene in a soft tissue perineurioma case.
authors: Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, MO.
authors: Deiter J
authors: DJ
authors: Duff
authors: Molecular Cytogenetics Department, St. Louis University Medical Center, SSM Cardinal Glennon Children's Medical Center, St. Louis, MO.
authors: Miguel A
authors: MA
authors: Guzman
authors: Department of Pathology/Pediatrics, St. Louis University Medical Center, SSM Cardinal Glennon Children's Medical Center, St. Louis, MO. Electronic address: Batanijr@Slu.edu.
authors: Jacqueline R
authors: JR
authors: Batanian
mesh_terms: D000293:Adolescent; D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis; D005260:Female; D016313:Genes, abl; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods; D018317:Nerve Sheath Neoplasms / Q000235:genetics*; D016315:Proto-Oncogene Proteins c-abl / Q000235:genetics; D014178:Translocation, Genetic
chemical_list: D016315:Proto-Oncogene Proteins c-abl
keywords: ABL1 gene; Three-way translocation; perineurioma