title: Maternal serum apelin and YKL-40 levels in early and late-onset pre-eclampsia.
abstract: OBJECTIVE
  The aim of the present study is to investigate whether alterations in the serum levels of apelin and YKL-40 differ between early and late onset pre-eclampsia and whether there is a correlation between apelin and YKL-40 in women who subsequently develop early and late pre-eclampsia.
  
  
  METHODS
  A total number of 80 pregnant women, 40 with normal pregnancy and 40 with pre-eclampsia, were included in the present study. Both the normal pregnant and pre-eclamptic subjects were subdivided into two groups. Serum YKL-40 and apelin concentrations were measured.
  
  
  RESULTS
  Mean maternal serum YKL-40 levels were both lower in women who subsequently developed early (87.45 ± 3.07 versus 103.40 ± 4.29) or late (96.43 ± 4.06 versus 99.87 ± 3.63) pre-eclampsia than those who remained normotensive. The difference was significant in early-onset preeclamptic women (p < 0.05) rather than late-onset pre-eclamptic ones (p > 0.05). Mean maternal serum apelin levels were both higher in women who subsequently developed early (8.6 ± 3.6 versus 5.7 ± 1.2) or late (9.6 ± 2.5 versus 8.1 ± 1.8) pre-eclampsia than those who remained normotensive. The difference was significant in early-onset preeclamptic women (p < 0.05) rather than late-onset pre-eclamptic ones (p > 0.05). There was a significant negative correlation between serum apelin and YKL-40 levels (r = -0.48, p = 0.001).
  
  
  CONCLUSIONS
  Circulating levels of apelin are significantly increased in early-onset pre-eclampsia, indicating the role of apelin in the discrimination of the early-onset of pre-eclampsia. On the other hand, maternal serum YKL-40 levels are not elavated significantly, indicating that adipose-derived apelin is primarily involved in the vascular pathogenesis of early-onset pre-eclampsia than macrophage-derived YKL-40.
authors: Department of Biochemistry and.
authors: Mine
authors: M
authors: Kucur
authors: Abdullah
authors: A
authors: Tuten
authors: Mahmut
authors: M
authors: Oncul
authors: Abdullah Serdar
authors: AS
authors: Acikgoz
authors: Mehmet Aytac
authors: MA
authors: Yuksel
authors: Metehan
authors: M
authors: Imamoglu
authors: Ozlem
authors: O
authors: Balci Ekmekci
authors: Nevin
authors: N
authors: Yilmaz
authors: Riza
authors: R
authors: Madazli
mesh_terms: D054392:Adipokines / Q000097:blood*; D000328:Adult; D000073861:Apelin; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D000071451:Chitinase-3-Like Protein 1; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D037102:Lectins / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D055815:Young Adult
chemical_list: C115436:APLN protein, human; D054392:Adipokines; D000073861:Apelin; D015415:Biomarkers; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1; D036341:Intercellular Signaling Peptides and Proteins; D037102:Lectins
keywords: Apelin; Early-onset; Late-onset; Pre-eclampsia; YKL-40.