title: Sleep duration and age-related changes in brain structure and cognitive performance.
abstract: OBJECTIVE
  To investigate the contribution of sleep duration and quality to age-related changes in brain structure and cognitive performance in relatively healthy older adults.
  
  
  METHODS
  Community-based longitudinal brain and cognitive aging study using a convenience sample.
  
  
  METHODS
  Participants were studied in a research laboratory.
  
  
  METHODS
  Relatively healthy adults aged 55 y and older at study commencement.
  
  
  METHODS
  N/A.
  
  
  RESULTS
  Participants underwent magnetic resonance imaging and neuropsychological assessment every 2 y. Subjective assessments of sleep duration and quality and blood samples were obtained. Each hour of reduced sleep duration at baseline augmented the annual expansion rate of the ventricles by 0.59% (P = 0.007) and the annual decline rate in global cognitive performance by 0.67% (P = 0.050) in the subsequent 2 y after controlling for the effects of age, sex, education, and body mass index. In contrast, global sleep quality at baseline did not modulate either brain or cognitive aging. High-sensitivity C-reactive protein, a marker of systemic inflammation, showed no correlation with baseline sleep duration, brain structure, or cognitive performance.
  
  
  CONCLUSIONS
  In healthy older adults, short sleep duration is associated with greater age-related brain atrophy and cognitive decline. These associations are not associated with elevated inflammatory responses among short sleepers.
  
  
  BACKGROUND
  Lo JC, Loh KK, Zheng H, Sim SK, Chee MW. Sleep duration and age-related changes in brain structure and cognitive performance.
authors: Center for Cognitive Neuroscience, Neuroscience and Behavioral Disorders Program, Duke-NUS Graduate Medical School, Singapore.
authors: June C
authors: JC
authors: Lo
authors: Center for Cognitive Neuroscience, Neuroscience and Behavioral Disorders Program, Duke-NUS Graduate Medical School, Singapore.
authors: Kep Kee
authors: KK
authors: Loh
authors: Center for Cognitive Neuroscience, Neuroscience and Behavioral Disorders Program, Duke-NUS Graduate Medical School, Singapore.
authors: Hui
authors: H
authors: Zheng
authors: Center for Cognitive Neuroscience, Neuroscience and Behavioral Disorders Program, Duke-NUS Graduate Medical School, Singapore.
authors: Sam K Y
authors: SK
authors: Sim
authors: Center for Cognitive Neuroscience, Neuroscience and Behavioral Disorders Program, Duke-NUS Graduate Medical School, Singapore.
authors: Michael W L
authors: MW
authors: Chee
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology*; D001284:Atrophy / Q000503:physiopathology; D015992:Body Mass Index; D001921:Brain / Q000033:anatomy & histology* / Q000502:physiology*; D002097:C-Reactive Protein / Q000032:analysis; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012890:Sleep / Q000502:physiology*; D012893:Sleep Wake Disorders / Q000503:physiopathology; D013997:Time Factors
chemical_list: D002097:C-Reactive Protein
keywords: aging; brain structure; cognitive performance; sleep duration; sleep quality