title: Parametric mapping and quantitative analysis of the human calvarium.
abstract: In this paper we report how thickness and density vary over the calvarium region of a collection of human skulls. Most previous reports involved a limited number of skulls, with a limited number of measurement sites per skull, so data in the literature are sparse. We collected computer tomography (CT) scans of 51 ex vivo human calvaria, and analyzed these in silico using over 2000 measurement sites per skull. Thickness and density were calculated at these sites, for the three skull layers separately and combined, and were mapped parametrically onto the skull surfaces to examine the spatial variations per skull. These were found to be highly variable, and unique descriptors of the individual skulls. Of the three skull layers, the thickness of the inner cortical layer was found to be the most variable, while the least variable was the outer cortical density.
authors: BURL Concepts, Inc., San Diego, CA, USA. Electronic address: arne@burlconcepts.com.
authors: Arne
authors: A
authors: Voie
authors: BURL Concepts, Inc., San Diego, CA, USA.
authors: Maximilian
authors: M
authors: Dirnbacher
authors: BURL Concepts, Inc., San Diego, CA, USA.
authors: David
authors: D
authors: Fisher
authors: BURL Concepts, Inc., San Diego, CA, USA; Department of Radiology, University of California San Diego, San Diego, CA, USA; Department of Neurosciences, University of California San Diego, San Diego, CA, USA.
authors: Thilo
authors: T
authors: Hölscher
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods*; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density / Q000502:physiology*; D002102:Cadaver; D003198:Computer Simulation; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012886:Skull / Q000033:anatomy & histology / Q000000981:diagnostic imaging* / Q000502:physiology*; D014057:Tomography, X-Ray Computed / Q000379:methods*
keywords: Computed tomography; Density; Human calvaria; Parametric maps; Thickness