title: Translational challenges in targeting latent HIV infection and the CNS reservoir problem.
abstract: Too controversial to discuss only a short time ago, achieving a cure for HIV infection has become a priority in HIV research. However, substantial challenges must be overcome. Among key hurdles to be surmounted is the definition of a reliable, validated model in which to test latency reversal agents (LRAs), as current primary cell models differ in their response to such agents. Animal models such as the HIV-infected humanized BLT mouse and SIV-infected macaque will be essential to study LRAs and to quantify their effects in anatomic reservoirs. Of several potential anatomic reservoirs, the central nervous system presents a significant obstacle, as it is known to harbor persistent HIV infection and is difficult to access for study and therapeutic intervention.
authors: Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
authors: Carolina
authors: C
authors: Garrido
authors: David M
authors: DM
authors: Margolis
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000494:pharmacology; D001921:Brain / Q000821:virology*; D004195:Disease Models, Animal; D004197:Disease Reservoirs / Q000821:virology*; D006678:HIV / Q000502:physiology; D015658:HIV Infections / Q000628:therapy*; D006801:Humans; D057170:Translational Research, Biomedical; D017735:Virus Latency / Q000187:drug effects / Q000502:physiology
chemical_list: D019380:Anti-HIV Agents