title: The role of calcium and cyclic nucleotide signaling in cerebellar granule cell migration under normal and pathological conditions.
abstract: In the developing brain, immature neurons migrate from their sites of origin to their final destination, where they reside for the rest of their lives. This active movement of immature neurons is essential for the formation of normal neuronal cytoarchitecture and proper differentiation. Deficits in migration result in the abnormal development of the brain, leading to a variety of neurological disorders. A myriad of extracellular guidance molecules and intracellular effector molecules is involved in controlling the migration of immature neurons in a cell type, cortical layer and birth-date-specific manner. To date, little is known about how extracellular guidance molecules transfer their information to the intracellular effector molecules, which regulate the migration of immature neurons. In this article, to fill the gap between extracellular guidance molecules and intracellular effector molecules, using the migration of cerebellar granule cells as a model system of neuronal cell migration, we explore the role of second messenger signaling (specifically Ca(2+) and cyclic nucleotide signaling) in the regulation of neuronal cell migration. We will, first, describe the cortical layer-specific changes in granule cell migration. Second, we will discuss the roles of Ca(2+) and cyclic nucleotide signaling in controlling granule cell migration. Third, we will present recent studies showing the roles of Ca(2+) and cyclic nucleotide signaling in the deficits in granule cell migration in mouse models of fetal alcohol spectrum disorders and fetal Minamata disease.
authors: Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, 44195.
authors: Yutaro
authors: Y
authors: Komuro
authors: Ludovic
authors: L
authors: Galas
authors: Alexis
authors: A
authors: Lebon
authors: Emilie
authors: E
authors: Raoult
authors: Jennifer K
authors: JK
authors: Fahrion
authors: Amanda
authors: A
authors: Tilot
authors: Tasturo
authors: T
authors: Kumada
authors: Nobuhiko
authors: N
authors: Ohno
authors: David
authors: D
authors: Vaudry
authors: Hitoshi
authors: H
authors: Komuro
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002465:Cell Movement; D002531:Cerebellum / Q000166:cytology*; D006801:Humans; D051379:Mice; D023421:Models, Animal; D009422:Nervous System Diseases / Q000378:metabolism / Q000473:pathology; D009474:Neurons / Q000502:physiology*; D009712:Nucleotides, Cyclic / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D009712:Nucleotides, Cyclic; D002118:Calcium
keywords: Ca2+ signaling; cyclic nucleotide signaling; fetal Minamata disease.; fetal alcohol spectrum disorders; granule cell migration