title: Allergy-related evidences in relation to serum IgE: data from the China state key laboratory of respiratory disease, 2008-2013.
abstract: OBJECTIVE
  To investigate the serum total IgE (tIgE) and specific IgE (sIgE) to common allergens among allergic patients in Guangzhou, China.
  
  
  METHODS
  7 085 patients were examined for tIgE and sIgE to 15 allergens, based on the protocols of reversed enzyme allergosorbent test and the sandwich enzyme-linked immunosorbent assay.
  
  
  RESULTS
  3 758 (53.04%) patients tested positive for tIgE, and 4 640 (65.49%) for sIgE. Der pteronyssinus, Der farinae, eggs, and cow's milk were the most common allergens leading to higher positive rates of sIgE responses. Several peaks of sensitization were: Der pteronyssinus, Der farinae, and Blomia tropicalis at age 10-12; cow's milk at age below 3; eggs at age 4-6. The mean level and positive rate of tIgE tended to increase in subjects sensitized to more allergens. Sensitization to Der pteronyssinus (OR, 1.6; P<0.05), Der farinae (OR, 1.5; P<0.05), Blomia tropicalis (OR, 1.4; P<0.05), Blattella germanica (OR, 1.5; P<0.05), cow's milk (OR, 1.3; P<0.05), and soy beans (OR, 2.0; P<0.05) were independently correlated with allergy-related conditions in preliminary diagnosis.
  
  
  CONCLUSIONS
  The major allergens in Guangzhou include Der pteronyssinus, Der farinae, cow's milk, and eggs. Sensitization to these allergens appears to be predictors of allergy-related disorder.
authors: State Key Laboratory of Respiratory Disease, National Clinical Center for Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, Guangdong, China.
authors: Bao Qing
authors: BQ
authors: Sun
authors: Department of Pediatrics, First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, Guangdong, China.
authors: De Hui
authors: DH
authors: Chen
authors: State Key Laboratory of Respiratory Disease, National Clinical Center for Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, Guangdong, China.
authors: Pei Yan
authors: PY
authors: Zheng
authors: State Key Laboratory of Respiratory Disease, National Clinical Center for Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, Guangdong, China.
authors: Hui Min
authors: HM
authors: Huang
authors: State Key Laboratory of Respiratory Disease, National Clinical Center for Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, Guangdong, China.
authors: Wen Ting
authors: WT
authors: Luo
authors: State Key Laboratory of Respiratory Disease, National Clinical Center for Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, Guangdong, China.
authors: Guang Qiao
authors: GQ
authors: Zeng
authors: Department of Otorhinolaryngology-Head & Neck Surgery, First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, Guangdong, China.
authors: Xiao Wen
authors: XW
authors: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000485:Allergens / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000097:blood* / Q000453:epidemiology / Q000276:immunology; D007073:Immunoglobulin E / Q000097:blood*; D007223:Infant; D007753:Laboratories; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012140:Respiratory Tract Diseases / Q000097:blood* / Q000453:epidemiology / Q000276:immunology*; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D000485:Allergens; D007073:Immunoglobulin E
keywords: Allergen; Allergy; Serum IgE; Symptoms