title: An unusual case of mycosis fungoides with high proliferation index and C-MYC/8q24 translocation.
abstract: Mycosis fungoides is the most common entity among all cutaneous T cell lymphomas. Herein, we report for the first time a case of mycosis fungoides in a 51-year-old man with aggressive clinical course and confirmed C-MYC/8q24 translocation. Review of the literature reveals that dermal Ki-67 proliferation index not only correlates with the type and extent of skin involvement and clinical stage, but is also an independent adverse prognostic factor. Mycosis fungoides is associated with multiple genomic abnormalities, particularly in patients with tumor stage and advanced clinical stage, and gain of C-MYC/8q24 is associated with a shorter survival. Our patient showed a high dermal Ki-67 level and concomitant C-MYC/8q24 translocation, which may account for the aggressive clinical course and refractoriness to CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy.
authors: Zhuang
authors: Z
authors: Feng
authors: Jun
authors: J
authors: Zhou
authors: Gail
authors: G
authors: Bentley
mesh_terms: D015415:Biomarkers; D004268:DNA-Binding Proteins / Q000235:genetics; D006801:Humans; D019394:Ki-67 Antigen / Q000096:biosynthesis; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology*; D011379:Prognosis; D012737:Sex Factors; D012867:Skin / Q000503:physiopathology; D014157:Transcription Factors / Q000235:genetics
chemical_list: D015415:Biomarkers; D004268:DNA-Binding Proteins; D019394:Ki-67 Antigen; C116115:MYCBP protein, human; D014157:Transcription Factors