title: Undiagnosed Borrmann type II gastric cancer due to necrosis and regenerative epithelium.
abstract: Endoscopic biopsy is essential to the proper diagnosis and treatment of gastric cancer. Unfortunately, the results of endoscopic biopsy are not always the same as what is expected based on gross endoscopic findings. The results of endoscopic biopsy can be negative for malignancy in Borrmann type IV advanced gastric cancer (AGCa) or gastric lymphoma. However, in the case of type II AGCa, repeated biopsies negative for malignancy have not been reported. A 49-year-old male patient underwent esophagogastroduodenoscopy three times due to large gastric ulcer suspected to be Borrmann type II cancer. However, three repeat endoscopic biopsies with multiple specimens showed necrosis and superficial regenerative epithelium without malignant findings. The patient underwent laparoscopic distal gastrectomy with D2 lymph node dissection. The surgical specimen revealed that the mucosal layer was completely replaced with regenerative epithelium without cancer cells.
authors: Joon Hur, Jae Hyuck Chang, Hoon Young Ko, Jong Hwan Lee, Soo Jeong Kim, Mi Ae Song, Tae Ho Kim, Chang Whan Kim, Sok Won Han, Division of Gastroenterology, Department of Internal Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Bucheon 420-717, South Korea.
authors: Joon
authors: J
authors: Hur
authors: Joon Hur, Jae Hyuck Chang, Hoon Young Ko, Jong Hwan Lee, Soo Jeong Kim, Mi Ae Song, Tae Ho Kim, Chang Whan Kim, Sok Won Han, Division of Gastroenterology, Department of Internal Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Bucheon 420-717, South Korea.
authors: Jae Hyuck
authors: JH
authors: Chang
authors: Joon Hur, Jae Hyuck Chang, Hoon Young Ko, Jong Hwan Lee, Soo Jeong Kim, Mi Ae Song, Tae Ho Kim, Chang Whan Kim, Sok Won Han, Division of Gastroenterology, Department of Internal Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Bucheon 420-717, South Korea.
authors: Byung Kee
authors: BK
authors: Kim
authors: Joon Hur, Jae Hyuck Chang, Hoon Young Ko, Jong Hwan Lee, Soo Jeong Kim, Mi Ae Song, Tae Ho Kim, Chang Whan Kim, Sok Won Han, Division of Gastroenterology, Department of Internal Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Bucheon 420-717, South Korea.
authors: Hoon Young
authors: HY
authors: Ko
authors: Joon Hur, Jae Hyuck Chang, Hoon Young Ko, Jong Hwan Lee, Soo Jeong Kim, Mi Ae Song, Tae Ho Kim, Chang Whan Kim, Sok Won Han, Division of Gastroenterology, Department of Internal Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Bucheon 420-717, South Korea.
authors: Jong Hwan
authors: JH
authors: Lee
authors: Joon Hur, Jae Hyuck Chang, Hoon Young Ko, Jong Hwan Lee, Soo Jeong Kim, Mi Ae Song, Tae Ho Kim, Chang Whan Kim, Sok Won Han, Division of Gastroenterology, Department of Internal Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Bucheon 420-717, South Korea.
authors: Soo Jeong
authors: SJ
authors: Kim
authors: Joon Hur, Jae Hyuck Chang, Hoon Young Ko, Jong Hwan Lee, Soo Jeong Kim, Mi Ae Song, Tae Ho Kim, Chang Whan Kim, Sok Won Han, Division of Gastroenterology, Department of Internal Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Bucheon 420-717, South Korea.
authors: Mi Ae
authors: MA
authors: Song
authors: Joon Hur, Jae Hyuck Chang, Hoon Young Ko, Jong Hwan Lee, Soo Jeong Kim, Mi Ae Song, Tae Ho Kim, Chang Whan Kim, Sok Won Han, Division of Gastroenterology, Department of Internal Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Bucheon 420-717, South Korea.
authors: Tae Ho
authors: TH
authors: Kim
authors: Joon Hur, Jae Hyuck Chang, Hoon Young Ko, Jong Hwan Lee, Soo Jeong Kim, Mi Ae Song, Tae Ho Kim, Chang Whan Kim, Sok Won Han, Division of Gastroenterology, Department of Internal Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Bucheon 420-717, South Korea.
authors: Chang Whan
authors: CW
authors: Kim
authors: Joon Hur, Jae Hyuck Chang, Hoon Young Ko, Jong Hwan Lee, Soo Jeong Kim, Mi Ae Song, Tae Ho Kim, Chang Whan Kim, Sok Won Han, Division of Gastroenterology, Department of Internal Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Bucheon 420-717, South Korea.
authors: Sok Won
authors: SW
authors: Han
mesh_terms: D001706:Biopsy; D017024:Chemotherapy, Adjuvant; D016099:Endoscopy, Gastrointestinal; D019160:Endosonography; D005743:Gastrectomy; D005753:Gastric Mucosa / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D011237:Predictive Value of Tests; D012038:Regeneration; D013274:Stomach Neoplasms / Q000145:classification / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
keywords: Biopsy; Endoscopy; Regeneration; Stomach neoplasm; Stomach ulcer