title: Increased Incidence of juvenile onset systemic lupus erythematosus in children with atopic dermatitis.
abstract: Herein, we investigated the risk of juvenile-onset systemic lupus erythematosus (JSLE) in children with atopic dermatitis (AD). From 2000 to 2007, 192,357 children with newly diagnosed AD and 769,428 matched non-AD controls were identified. By the end of 2008, incidences and hazard ratios (HRs) of JSLE were measured. JSLE incidence in the AD cohort was 2.90-fold greater than that in the non-AD cohort (3.25 vs. 1.12 per 100,000 person-years), with a Cox model-measured adjusted HR of 2.92 (95% CI: 1.85-4.60); the risk of JSLE was greater for older children and girls. The AD-to-non-AD cohort HR was 6.6 (95% CI: 2.88-13.1) for children aged >12 years compared with 1.81 (95% CI: 0.98-3.32) for children aged ≤ 12 years. The HR of JSLE in AD children increased from 1.55 (95% CI: 0.88-2.76) for those with ≤ 3 clinical visits to 66.3 (95% CI: 33.1-132.8) for those with >6 visits (p < 0.0001, by trend test). The risk of developing SLE in the AD cohort was the highest within five years after AD diagnosis (HR: 4.02; 95% CI: 2.83-7.08). Children with AD are at a high risk of developing JSLE during their growth period.
authors: Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan College of Medicine, China Medical University, Taichung, Taiwan.
authors: C-C
authors: CC
authors: Wei
authors: Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan.
authors: C-L
authors: CL
authors: Lin
authors: Institute of Medicine, Chung Shan Medical University Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan.
authors: J-D
authors: JD
authors: Tsai
authors: College of Medicine, China Medical University, Taichung, Taiwan Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.
authors: T-C
authors: TC
authors: Shen
authors: Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan fcsung@mail.cmu.edu.tw d5522@mail.cmuh.org.tw.
authors: F-C
authors: FC
authors: Sung
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology*; D008297:Male; D009819:Office Visits / Q000706:statistics & numerical data; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D018570:Risk Assessment; D012424:Rural Population / Q000706:statistics & numerical data; D012737:Sex Factors; D013624:Taiwan / Q000453:epidemiology; D013997:Time Factors; D014505:Urban Population / Q000706:statistics & numerical data
keywords: Atopic dermatitis; children; juvenile systemic lupus erythematosus; population study; retrospective cohort study