title: Evaluation of miR-216a and miR-217 as potential biomarkers of acute pancreatic injury in rats and mice.
abstract: Mild injury of the exocrine pancreas is often asymptomatic and can be under- or mis-diagnosed. The pancreas-enriched microRNAs miR-216a and miR-217 were evaluated as potential serum biomarkers of exocrine pancreas injury in rodent models of acute pancreatitis induced by caerulein, l-arginine, and pancreatic duct ligation. Both microRNAs showed time- and dose- relevant responses to pancreatic injury and wider dynamic ranges of response than serum amylase or lipase. Pancreas-selective microRNAs were found to be relatively sensitive serum biomarkers of pancreatic injury in rodents with potentially greater specificity than the current standard assays.
authors: Division of Applied Regulatory Science, Center for Drug Evaluation and Research, US FDA , MD , USA.
authors: David
authors: D
authors: Goodwin
authors: Barry
authors: B
authors: Rosenzweig
authors: Jun
authors: J
authors: Zhang
authors: Lin
authors: L
authors: Xu
authors: Sharron
authors: S
authors: Stewart
authors: Karol
authors: K
authors: Thompson
authors: Rodney
authors: R
authors: Rouse
mesh_terms: D000681:Amylases / Q000097:blood; D000818:Animals; D001120:Arginine; D015415:Biomarkers / Q000097:blood; D002108:Ceruletide; D008297:Male; D008810:Mice, Inbred C57BL; D035683:MicroRNAs / Q000097:blood*; D010179:Pancreas / Q000473:pathology*; D010195:Pancreatitis / Q000097:blood* / Q000139:chemically induced; D012372:ROC Curve; D017207:Rats, Sprague-Dawley
chemical_list: D015415:Biomarkers; C000591813:MIRN-217 microRNA, mouse; C553402:MIRN216 microRNA, mouse; D035683:MicroRNAs; D002108:Ceruletide; D001120:Arginine; D000681:Amylases
keywords: Caerulein; microRNA; pancreas; pancreatitis