title: Primary Cutaneous Gamma-Delta T-Cell Lymphoproliferative Disorder in a 3-Year-Old Boy.
abstract: Primary cutaneous gamma-delta T-cell lymphoma (PCGD-TCL) is a rare disorder, constituting less than 1% of primary cutaneous lymphomas. Most cases occur in adults and may present as plaques or nodules with ulceration. Here we describe an unusual case of PCGD-TCL in a 3-year-old boy who presented with asymptomatic subcutaneous nodules. To our knowledge, this report represents one of the youngest reported patients with gamma-delta lymphoma/lymphoproliferative disorder. In addition, our patient has an indolent clinical presentation with greater than 1 year clinical follow-up. Because gamma-delta T-cell lymphomas are exceedingly rare in children, we acknowledge that the clinical course/outcome in young patients is still unclear. We hope to add to the recognition that PCGD-TCLs demonstrate a wide clinical spectrum of disease with relatively indolent presentations in some cases.
authors: Departments of *Pathology, †Pediatric Hematology and Oncology, and ‡Dermatology, Stanford University Medical Center, Stanford, CA.
authors: Christopher W M
authors: CW
authors: Soon
authors: Michael
authors: M
authors: Link
authors: Youn H
authors: YH
authors: Kim
authors: Jinah
authors: J
authors: Kim
mesh_terms: D017252:CD3 Complex / Q000032:analysis*; D002675:Child, Preschool; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000737:chemistry* / Q000473:pathology*; D008297:Male; D039102:Poly(A)-Binding Proteins / Q000032:analysis; D035583:Rare Diseases / Q000378:metabolism / Q000473:pathology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis*; D012878:Skin Neoplasms / Q000737:chemistry* / Q000473:pathology*; D000074019:T-Cell Intracellular Antigen-1
chemical_list: D017252:CD3 Complex; D039102:Poly(A)-Binding Proteins; D016692:Receptors, Antigen, T-Cell, gamma-delta; D000074019:T-Cell Intracellular Antigen-1; C071558:TIA1 protein, human