title: Transmission potential of antimony-resistant leishmania field isolates.
abstract: We studied the development of antimony-resistant Leishmania infantum in natural vectors Lutzomyia longipalpis and Phlebotomus perniciosus to ascertain the risk of parasite transmission by sand flies. All three resistant strains produced fully mature late-stage infections in sand flies; moreover, the resistant phenotype was maintained after the passage through the vector. These results highlight the risk of circulation of resistant Leishmania strains and question the use of human drugs for treatment of dogs as Leishmania reservoirs.
authors: Department of Parasitology, Faculty of Science, Charles University in Prague, Prague, Czech Republic.
authors: Veronika
authors: V
authors: Seblova
authors: MIVEGEC (UM1/UM2-CNRS5290-IRD224), Institut de Recherche pour le Développement (IRD), Montpellier, France.
authors: Bruno
authors: B
authors: Oury
authors: Service d'Eco-épidémiologie Parasitaire et Génétique des Populations Parasitologie, Institut Pasteur d'Algérie, Dely Ibrahim, Alger, Algeria.
authors: Naouel
authors: N
authors: Eddaikra
authors: Ecole Nationale Supérieure Vétérinaire d'Alger, Hassan Badi El-Harrach, Alger, Algeria.
authors: Khatima
authors: K
authors: Aït-Oudhia
authors: MIVEGEC (UM1/UM2-CNRS5290-IRD224), Institut de Recherche pour le Développement (IRD), Montpellier, France.
authors: Francine
authors: F
authors: Pratlong
authors: Centre de Recherche en Infectiologie du CHUL, Québec, Québec, Canada.
authors: Elodie
authors: E
authors: Gazanion
authors: Unidade de Parasitologia Médica (UPM), Centro de Malária e outras Doenças Tropicais (CMDT), Instituto de Higiene e Medicina Tropical (IHMT), Universidade Nova de Lisboa (UNL), Lisbon, Portugal.
authors: Carla
authors: C
authors: Maia
authors: Department of Parasitology, Faculty of Science, Charles University in Prague, Prague, Czech Republic.
authors: Petr
authors: P
authors: Volf
authors: MIVEGEC (UM1/UM2-CNRS5290-IRD224), Institut de Recherche pour le Développement (IRD), Montpellier, France denis.sereno@ird.fr.
authors: Denis
authors: D
authors: Sereno
mesh_terms: D000818:Animals; D000965:Antimony / Q000494:pharmacology*; D007303:Insect Vectors; D007891:Leishmania / Q000472:pathogenicity; D018314:Leishmania infantum / Q000472:pathogenicity; D010691:Phlebotomus / Q000469:parasitology; D011576:Psychodidae / Q000469:parasitology
chemical_list: D000965:Antimony