title: Characteristics, management modalities and outcome in chronic systolic heart failure patients treated in tertiary care centers: results from the EVIdence based TreAtment in Heart Failure (EVITA-HF) registry.
abstract: BACKGROUND
  Limited data exist regarding baseline characteristics and management of heart failure with reduced ejection fraction (EF) in tertiary care facilities.
  
  
  METHODS
  EVITA-HF comprises web-based case report data on demography, comorbidities, diagnostic and therapy measures, quality of life, adverse events and 1-year follow-up of patients hospitalized for chronic heart failure and an ejection fraction of less than 40%.
  
  
  RESULTS
  Between February 2009 and June 2011, a total of 1,853 consecutive, hospitalized patients (pts) were included in 16 centers in Germany. Mean age was 70 years, 76% were male. Median EF was 30%, and 63% were in NYHA III/IV. Ischemic cardiomyopathy was present in 56%, history of hypertension in 76%, diabetes in 39%, impaired renal function in 33%, thyroid dysfunction in 12%, and malignoma in 7%. Sixty-eight percent of pts had a non-elective admission. Rhythm was sinus/atrial fibrillation or flutter/pacemaker in 64, 28 and 11%, respectively. Median heart rate amounted to 80 bpm, median blood pressure to 122/74 mmHg. LBBB was present in 26% of non-pacemaker pts. Eighteen percent had an ICD or CRT-D. Medication (admission vs. discharge) consisted of ACEI or ARB in 73 vs. 88%, β-blocker in 71 vs. 89%, mineral corticosteroid receptor antagonist (MRA) in 32 vs. 57%, diuretics in 68 vs. 83% (p < 0.001 for each). Forty-two percent of pts received a specific treatment procedure beyond pharmacotherapy, of these 48% revascularization, 39% device therapy, 14% electrical cardioversion, 5% ablation procedures, 9 % valvular procedures, 6% iv inotropes, 1.8% IABP or LVAD implantation. At discharge, 33% of survivors had ICD- or CRT-D implants. One-year mortality amounted to 16.8%, and death or rehospitalization to 56%. NYHA class III/IV was found in 30% (p < 0.001 vs. index admission), general health status was improved in 45% and unchanged in 36% of patients. Eighty-five percent of pts took ACEI or ARB, 86% β-blockers, 47% MRA, and 78% diuretics (p < 0.001 vs. index discharge for all).
  
  
  CONCLUSIONS
  Patients with chronic heart failure and low ejection fraction represent an elderly and multimorbid population. While hospitalized, they experience a significant optimization of prognosis-relevant medication, revascularization and device therapy. After 1 year, mortality is moderate; drug adherence is high and NYHA status favourable. The EVITA-HF registry is able to reflect coherently the real-world management, efforts and follow-up in heart failure pts managed in tertiary care facilities.
authors: I.Medizinische Klinik, Herzzentrum Augsburg-Schwaben, Klinikum Augsburg, Stenglinstr. 2, 86156, Augsburg, Germany, wolfgang.scheidt@klinikum-augsburg.de.
authors: W
authors: W
authors: von Scheidt
authors: C
authors: C
authors: Zugck
authors: M
authors: M
authors: Pauschinger
authors: R
authors: R
authors: Hambrecht
authors: O
authors: O
authors: Bruder
authors: A
authors: A
authors: Hartmann
authors: M
authors: M
authors: Rauchhaus
authors: R
authors: R
authors: Zahn
authors: J
authors: J
authors: Brachmann
authors: U
authors: U
authors: Tebbe
authors: T
authors: T
authors: Neumann
authors: R H
authors: RH
authors: Strasser
authors: M
authors: M
authors: Böhm
authors: S
authors: S
authors: Störk
authors: M
authors: M
authors: Hochadel
authors: P
authors: P
authors: Heidemann
authors: J
authors: J
authors: Senges
mesh_terms: D000368:Aged; D058406:Cardiac Resynchronization Therapy / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D005858:Germany / Q000453:epidemiology; D054143:Heart Failure, Systolic / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D017052:Hospital Mortality / Q000639:trends; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012042:Registries; D012189:Retrospective Studies; D013318:Stroke Volume; D015996:Survival Rate / Q000639:trends; D062606:Tertiary Care Centers; D013997:Time Factors; D016896:Treatment Outcome