title: Proteolytic stability of amphipathic peptide hydrogels composed of self-assembled pleated β-sheet or coassembled rippled β-sheet fibrils.
abstract: Hydrogel networks composed of rippled β-sheet fibrils of coassembled D- and L-Ac-(FKFE)2-NH2 amphipathic peptides exhibit proteolytic stability and increased rheological strength compared to networks of self-assembled L-Ac-(FKFE)2-NH2 pleated β-sheet fibrils. Modifying the ratios of l and d peptides in the coassembled rippled β-sheet fibrils alters the degradation profiles of these hydrogel networks.
authors: Department of Chemistry, University of Rochester, Rochester, NY 14627-0216, USA. nilsson@chem.rochester.edu.
authors: Ria J
authors: RJ
authors: Swanekamp
authors: Jade J
authors: JJ
authors: Welch
authors: Bradley L
authors: BL
authors: Nilsson
mesh_terms: D020100:Hydrogels / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D055550:Protein Stability; D017433:Protein Structure, Secondary; D059748:Proteolysis
chemical_list: D020100:Hydrogels; D010455:Peptides