title: Spindle cell sarcoma of the vulva with myofibroblastic differentiation.
abstract: OBJECTIVE
  Primary vulvar sarcomas are rare lesions of the lower genital tract. We report the case of a patient with a spindle cell sarcoma of the vulva.
  
  
  METHODS
  A 44-year-old woman presented with a painless vulvar mass. Vulvar biopsy demonstrated a spindle cell sarcoma with myofibroblastic differentiation.
  
  
  RESULTS
  Pretreatment evaluation revealed no evidence of metastatic disease, and magnetic resonance imaging found no local masses. The patient underwent right radical vulvectomy with negative margins and tolerated the procedure well.
  
  
  CONCLUSIONS
  Women undergoing gynecologic care should have routine evaluation of the vulva to detect these rare neoplasms.
authors: Departments of 1Obstetrics and Gynecology and 2Pathology, and 3Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, NY.
authors: Amanda J
authors: AJ
authors: Adeleye
authors: Nicholas
authors: N
authors: Palmeri
authors: Shih-Hsiu J
authors: SH
authors: Wang
authors: Xiaolin
authors: X
authors: Liu-Jarin
authors: Jason D
authors: JD
authors: Wright
mesh_terms: D000328:Adult; D001706:Biopsy; D002148:Calmodulin-Binding Proteins / Q000032:analysis; D002454:Cell Differentiation; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D008853:Microscopy; D009379:Neoplasms, Muscle Tissue / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery; D012509:Sarcoma / Q000175:diagnosis* / Q000473:pathology*; D014844:Vulva / Q000473:pathology* / Q000601:surgery; D014846:Vulvar Neoplasms / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery
chemical_list: D002148:Calmodulin-Binding Proteins