title: Vitamin D and Dysfunctional Adipose Tissue in Obesity.
abstract: Vitamin D deficiency and dysfunctional adipose tissue are involved in the development of cardiometabolic disturbances (eg, hypertension, insulin resistance, type 2 diabetes mellitus, obesity, and dyslipidemia). We evaluated the relation between vitamin D and adipocytokines derived from adipose tissue. We studied 50 obese individuals who were classified into different subgroups according to medians of observed anthropometric parameters (body mass index, body fat percentage, waist circumference, and trunk fat mass). There was a negative correlation between vitamin D level and leptin and resistin (r = -.61, P < .01), while a positive association with adiponectin concentrations was found (r = .7, P < .001). Trend estimation showed that increase in vitamin D level is accompanied by intensive increase in adiponectin concentrations (growth coefficient: 12.13). In conclusion, a positive trend was established between vitamin D and the protective adipocytokine adiponectin. The clinical relevance of this relationship needs to be investigated in larger studies.
authors: Medical Faculty in Novi Sad, Clinical Center of Vojvodina, Novi Sad, Serbia edith@sezampro.rs.
authors: Edita
authors: E
authors: Stokić
authors: Faculty of Technical Sciences, University of Novi Sad, Novi Sad, Serbia.
authors: Aleksandar
authors: A
authors: Kupusinac
authors: Medical Faculty in Novi Sad, Clinical Center of Vojvodina, Novi Sad, Serbia.
authors: Dragana
authors: D
authors: Tomic-Naglic
authors: Department of Anatomy, Medical Faculty, University of Novi Sad, Novi Sad, Serbia.
authors: Dragana
authors: D
authors: Smiljenic
authors: Medical Faculty in Novi Sad, Clinical Center of Vojvodina, Novi Sad, Serbia.
authors: Branka
authors: B
authors: Kovacev-Zavisic
authors: Department of Anatomy, Medical Faculty, University of Novi Sad, Novi Sad, Serbia.
authors: Biljana
authors: B
authors: Srdic-Galic
authors: Laboratory for Molecular Genetics and Radiobiology, Institute of Nuclear Sciences "Vinca", University of Belgrade, Belgrade, Serbia.
authors: Sanja
authors: S
authors: Soskic
authors: Laboratory for Molecular Genetics and Radiobiology, Institute of Nuclear Sciences "Vinca", University of Belgrade, Belgrade, Serbia.
authors: Esma R
authors: ER
authors: Isenovic
mesh_terms: D052242:Adiponectin / Q000097:blood; D000273:Adipose Tissue / Q000503:physiopathology*; D000328:Adult; D000886:Anthropometry; D015415:Biomarkers / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D020738:Leptin / Q000097:blood; D008297:Male; D009765:Obesity / Q000145:classification / Q000150:complications* / Q000503:physiopathology*; D052243:Resistin / Q000097:blood; D014807:Vitamin D / Q000097:blood; D014808:Vitamin D Deficiency / Q000150:complications* / Q000503:physiopathology*
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D020738:Leptin; D052243:Resistin; D014807:Vitamin D
keywords: adipocytokine; dysfunctional adipose tissue; obesity; vitamin D