title: Physical-capacity-related genetic polymorphisms in children with cystic fibrosis.
abstract: In patients with cystic fibrosis (CF), physical capacity (PC) has been correlated with mortality risk. In turn, PC is dependent on genetic factors. This study examines several polymorphisms associated with PC and health-related phenotype traits (VO2peak, FEV1, FVC, PImax and muscular strength) in a group of children with CF (n = 66, primary purpose). The same analyses were also performed in a control group of healthy children (n = 113, secondary purpose). The polymorphisms determined were classified as muscle function polymorphisms (ACE rs1799752; AGT rs699; ACTN3 rs1815739; PTK2 rs7843014 and rs7460; MSTN rs1805086; TRHR rs7832552; NOS3 rs2070744) or energy metabolism polymorphisms (PPARGC1A rs8192678; NRF1 rs6949152; NRF2 rs12594956; TFAM rs1937; PPARD rs2267668; ACSL1 rs6552828). No significant polymorphism/phenotype correlations were detected in children with CF, with marginal associations being observed between NOS3 rs2070744 and VO2peak and FEV1, as well as between PPARGC1A rs8192678 and FEV1. Overall, similar findings were observed in the control group, i.e., no major associations. The PC-related polymorphisms examined seem to have no effects on the PC or health of children with CF.
authors: School of Doctorate Studies and Research, Universidad Europea de Madrid, Madrid, Spain.
authors: Thomas
authors: T
authors: Yvert
authors: Catalina
authors: C
authors: Santiago
authors: Elena
authors: E
authors: Santana-Sosa
authors: Zoraida
authors: Z
authors: Verde
authors: Felix
authors: F
authors: Gómez-Gallego
authors: Luis M
authors: LM
authors: López-Mojares
authors: Margarita
authors: M
authors: Pérez
authors: Nuria
authors: N
authors: Garatachea
authors: Alejandro
authors: A
authors: Lucia
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000235:genetics* / Q000503:physiopathology; D005080:Exercise Test; D017079:Exercise Tolerance / Q000235:genetics* / Q000502:physiology; D005260:Female; D005541:Forced Expiratory Volume / Q000235:genetics / Q000502:physiology; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D053580:Muscle Strength / Q000235:genetics / Q000502:physiology; D010101:Oxygen Consumption / Q000235:genetics / Q000502:physiology; D010809:Physical Fitness / Q000502:physiology*; D020641:Polymorphism, Single Nucleotide; D014797:Vital Capacity / Q000235:genetics / Q000502:physiology