title: [The role of a molecule associated with drug dependence, shati/nat8l].
abstract: Various molecules are involved in drug addiction induced by drugs of abuse. Therefore, the mechanism of drug addiction is still not clear, and it has been a difficulty in the development of preventive and curative drugs for drug dependence. We tried to identify the molecules associated with drug dependence, and found three molecules including shati/nat81. Recently, it has been demonstrated that the substrate for shati/nat81 is aspaltate and shati/nat8l biosynthesizes N-acetylaspartate, which exists abundantly in the mammalian brain. In this study, we investigated the physiological function of shati/nat81 and the role of shati/nat81 in drug dependence. The overexpression of shati/nat81 in the dorsal striatum of mice led to social abnormality and depression-like behavior, and worsened a part of the motor dysfunction induced by Ca2+ channel agonist BAY-K 8644. The overexpression of shati/nat81 in the nucleus accumbens of mice inhibited methamphetamine-induced behavioral and biochemical abnormalities. These findings suggest that the shati/nat81-associated system could play a role in the regulation of mental activity and motor action, and be a new target in the development of therapeutic drugs for drug dependence.
authors: Yoshiaki
authors: Y
authors: Miyamoto
authors: Eriko
authors: E
authors: Saika
authors: Etsuro
authors: E
authors: Hori
authors: Noriyuki
authors: N
authors: Iegaki
authors: Kazuyuki
authors: K
authors: Sumi
authors: Toshitaka
authors: T
authors: Nabeshima
authors: Shin-ichi
authors: S
authors: Muramatsu
authors: Hisao
authors: H
authors: Nishijo
authors: Kyosuke
authors: K
authors: Uno
authors: Atsumi
authors: A
authors: Nitta
mesh_terms: D000123:Acetyltransferases / Q000378:metabolism*; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D008694:Methamphetamine / Q000494:pharmacology; D019966:Substance-Related Disorders / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D001224:Aspartic Acid; D008694:Methamphetamine; C000179:N-acetylaspartate; D000123:Acetyltransferases