title: Improved cycle outcomes after laparoscopic ovarian diathermy in hyper-responder patients with previous ART failure.
abstract: Excessive response to ovarian stimulation is common among hyper-responder patients undergoing assisted reproductive technology (ART). Cycle cancellations and severe ovarian hyperstimulation syndrome (OHSS) are all detrimental consequences observed within this cohort and several approaches have been proposed to enhance outcomes. The current study is designed to evaluate whether laparoscopic ovarian diathermy (LOD) improves ART outcomes and pregnancy rates by reducing Anti-mullerian hormone (AMH) levels in a group of patients who had a history of recurrent ART failure and high response. A total of 40 hyper-responder patients with history of previous ART failure were included. Group I consisted of 22 patients that underwent LOD prior to ART. Group II consisted of 18 patients that underwent only ART. Cycle outcomes of groups were compared. Following LOD, significant reduction in AMH levels were detected in group I (4.75 ng/mL to 2.25 ng/mL). Clinical pregnancies were similar among groups (40% versus 27.8% p = 0.65). There was no cycle cancellation in Group I, whereas there were three cycle cancellations observed due to OHSS in Group II. Our results indicate that LOD might offer enhanced fertility outcomes and may reduce the likelihood of cycle cancellations in hyper-responders with previous ART failures.
authors: a Department of Obstetrics and Gynaecology, Faculty of Medicine, Ufuk University Ankara Turkey.|b Centrum Clinic Women Health and IVF Center Ankara Turkey.
authors: Recai
authors: R
authors: Pabuccu
authors: a Department of Obstetrics and Gynaecology, Faculty of Medicine, Ufuk University Ankara Turkey.
authors: Emre Goksan
authors: EG
authors: Pabuccu
authors: a Department of Obstetrics and Gynaecology, Faculty of Medicine, Ufuk University Ankara Turkey.
authors: Asli Yarci
authors: AY
authors: Gursoy
authors: a Department of Obstetrics and Gynaecology, Faculty of Medicine, Ufuk University Ankara Turkey.
authors: Gamze Sinem
authors: GS
authors: Caglar
authors: a Department of Obstetrics and Gynaecology, Faculty of Medicine, Ufuk University Ankara Turkey.
authors: Muserref Banu
authors: MB
authors: Yilmaz
authors: c Zekai Tahir Burak Women Healthcare, Education and Research Hospital Ankara Turkey.
authors: Ozlem
authors: O
authors: Ozdegirmenci
mesh_terms: D000328:Adult; D003972:Diathermy; D005260:Female; D006801:Humans; D010535:Laparoscopy; D016471:Ovarian Hyperstimulation Syndrome / Q000209:etiology / Q000517:prevention & control*; D010062:Ovulation Induction / Q000009:adverse effects*; D011247:Pregnancy; D027724:Reproductive Techniques, Assisted / Q000009:adverse effects*; D016896:Treatment Outcome
keywords: Assisted reproductive technology; folliculogenesis; ovary