title: Alcohol enhances HIV infection of cord blood monocyte-derived macrophages.
abstract: Alcohol consumption or alcohol abuse is common among pregnant HIV(+) women and has been identified as a potential behavioral risk factor for the transmission of HIV. In this study, we examined the impact of alcohol on HIV infection of cord blood monocyte-derived macrophages (CBMDM). We demonstrated that alcohol treatment of CBMDM significantly enhanced HIV infection of CBMDM. Investigation of the mechanisms of alcohol action on HIV demonstrated that alcohol inhibited the expression of several HIV restriction factors, including anti-HIV microRNAs, APOBEC3G and APOBEC3H. Additionally, alcohol also suppressed the expression of IFN regulatory factor 7 (IRF-7) and retinoic acid-inducible gene I (RIG-I), an intracellular sensor of viral infection. The suppression of these IFN regulatory factors was associated with reduced expression of type I IFN. These experimental findings suggest that maternal alcohol consumption may facilitate HIV infection, promoting vertical transmission of HIV.
authors: Dimitrios S
authors: DS
authors: Mastrogiannis
authors: Xu
authors: X
authors: Wang
authors: Min
authors: M
authors: Dai
authors: Jieliang
authors: J
authors: Li
authors: Yizhong
authors: Y
authors: Wang
authors: Yu
authors: Y
authors: Zhou
authors: Selin
authors: S
authors: Sakarcan
authors: Juliet Crystal
authors: JC
authors: Pena
authors: Department of Pathology and Laboratory Medicine, Temple University School of Medicine Philadelphia, PA 19140, USA. wenzheho@temple.edu.
authors: Wenzhe
authors: W
authors: Ho
mesh_terms: D000071480:APOBEC-3G Deaminase; D000293:Adolescent; D000328:Adult; D000438:Alcohols / Q000378:metabolism*; D000619:Aminohydrolases / Q000096:biosynthesis; D003564:Cytidine Deaminase / Q000096:biosynthesis; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases / Q000096:biosynthesis; D015536:Down-Regulation; D005260:Female; D005312:Fetal Blood / Q000166:cytology*; D006678:HIV / Q000276:immunology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000378:metabolism*; D007231:Infant, Newborn; D050839:Interferon Regulatory Factor-7; D007370:Interferon Type I / Q000096:biosynthesis*; D008264:Macrophages / Q000187:drug effects* / Q000821:virology*; D011247:Pregnancy; D011971:Receptors, Immunologic; D055815:Young Adult
chemical_list: D000438:Alcohols; D007166:Immunosuppressive Agents; D050839:Interferon Regulatory Factor-7; D007370:Interferon Type I; D011971:Receptors, Immunologic; C529313:APOBEC3H protein, human; D000619:Aminohydrolases; D000071480:APOBEC-3G Deaminase; C464924:APOBEC3G protein, human; D003564:Cytidine Deaminase; C452820:RIGI protein, human; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases