title: Meta-analysis: low-dose intake of vitamin E combined with other vitamins or minerals may decrease all-cause mortality.
abstract: It has been suggested that vitamin E alone or combined with other vitamins or minerals can prevent oxidative stress and slow oxidative injury-related diseases, such as cardiovascular disease and cancer. A comprehensive search of PubMed/MEDLINE, EMBASE and the Cochrane Library was performed. Relative risk was used as an effect measure to compare the intervention and control groups. A total of 33 trials were included in the meta-analysis. Neither vitamin E intake alone (RR=1.01; 95% CI, 0.97 to 1.04; p=0.77) nor vitamin E intake combined with other agents (RR=0.97; 95% CI, 0.89 to 1.06; p=0.55) was correlated with all-cause mortality. Subgroup analyses revealed that low-dose vitamin E supplementation combined with other agents is associated with a statistically significant reduction in all-cause mortality (RR=0.92; 95% CI, 0.86 to 0.98; p=0.01), and vitamin E intake combined with other agents is associated with a statistically significant reduction in mortality rates among individuals without probable or confirmed diseases (RR=0.92; 95% CI, 0.86 to 0.99; p=0.02). Neither vitamin E intake alone nor combined with other agents is associated with a reduction in all-cause mortality. But a low dose (<400 IU/d) of vitamin E combined with other agents is correlated with a reduction in all-cause mortality, and vitamin E intake combined with other agents is correlated with a reduction in the mortality rate among individuals without probable or confirmed diseases.
authors: Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine.
authors: Shan
authors: S
authors: Jiang
authors: Zhenyu
authors: Z
authors: Pan
authors: Hui
authors: H
authors: Li
authors: Fenglan
authors: F
authors: Li
authors: Yanyan
authors: Y
authors: Song
authors: Yu
authors: Y
authors: Qiu
mesh_terms: D002318:Cardiovascular Diseases / Q000401:mortality / Q000517:prevention & control; D016208:Databases, Factual; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D006801:Humans; D009026:Mortality; D009369:Neoplasms / Q000401:mortality / Q000517:prevention & control; D016032:Randomized Controlled Trials as Topic; D014131:Trace Elements / Q000008:administration & dosage*; D014810:Vitamin E / Q000008:administration & dosage*; D014815:Vitamins / Q000008:administration & dosage*
chemical_list: D014131:Trace Elements; D014815:Vitamins; D014810:Vitamin E