title: [Chrysotile-asbestos induces cytogenetic effects in the rat's mesothelium in vitro and in vivo].
abstract: Under cultivation of rat peritoneal mesothelial cells in vitro in them there are appeared signs of the genomic instability, evidencing their transformation: increasing of the number of both binucleated cells with micronuclei and polynuclear cells and the increase of sizes and polymorphism. Asbestos greatly accelerates this process. Asbestos-induced carcinogenesis in vivo is accompanied in pleural mesothelium in the rats there also revealed with similar signs of genomic instability and cellular transformation.
authors: L N
authors: LN
authors: Pylev
authors: O V
authors: OV
authors: Smirnova
authors: L A
authors: LA
authors: Vasileva
authors: F I
authors: FI
authors: Ingel
mesh_terms: D000818:Animals; D017632:Asbestos, Serpentine / Q000633:toxicity*; D020732:Cytogenetic Analysis; D004848:Epithelium / Q000187:drug effects*; D042822:Genomic Instability / Q000187:drug effects; D010537:Peritoneum / Q000166:cytology / Q000187:drug effects*; D010994:Pleura / Q000187:drug effects* / Q000473:pathology; D051381:Rats
chemical_list: D017632:Asbestos, Serpentine