title: Serum levels of high-sensitivity troponin T: a novel marker for left ventricular remodeling and performance in hypertensive subjects.
abstract: It has been well established that high-sensitivity cardiac troponin T (hs-TnT) is a specific and highly sensitive marker in acute coronary syndromes. On the other hand, studies on serum concentrations of hs-TnT in patients with hypertension in the absence of significant coronary stenosis are limited. Therefore, we hypothesized that hs-TnT levels are related to left ventricular (LV) remodeling and performance in hypertension. We included 537 hemodynamically stable hypertensive subjects, 247 males aged 60.7 ± 11.1 years, and 100 normotensive subjects of similar age and gender. Clinical examination, clinical assessment and laboratory assays were performed for all hypertensive and normotensive subjects. The detectable rate (>0.003 ng/mL) and elevated rate (>0.013 ng/mL) of hs-TnT were higher in hypertensive subjects than those in normotensive subjects. hs-TnT level gradually increased in hypertensive subjects with LV normal geometry, concentric remodeling, concentric hypertrophy and eccentric hypertrophy. hs-TnT was independently related to age, gender, hypertension, fasting blood glucose, renal function, and LV hypertrophy, and diastolic function on multiple analysis during the whole participation. An increase in hs-TnT levels could be a reliable biomarker of cardiac remodeling and function in hypertension, as an indicator of subclinical ongoing cardiomyocyte injury.
authors: Department 2 of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China.
authors: D M
authors: DM
authors: Miao
authors: Department 2 of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China.
authors: L P
authors: LP
authors: Zhang
authors: Department 2 of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China.
authors: H P
authors: HP
authors: Yu
authors: Department 2 of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China.
authors: J Y
authors: JY
authors: Zhang
authors: Department 2 of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China.
authors: W K
authors: WK
authors: Xiao
authors: Department 2 of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China PingYEcn@163.com.
authors: P
authors: P
authors: Ye
mesh_terms: D000367:Age Factors; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D006332:Cardiomegaly / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D016022:Case-Control Studies; D005215:Fasting; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D032383:Myocytes, Cardiac / Q000378:metabolism / Q000473:pathology; D011379:Prognosis; D012737:Sex Factors; D020107:Troponin T / Q000097:blood*; D020257:Ventricular Remodeling
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D020107:Troponin T