title: Effects of enoxaparin and unfractionated heparin in prophylactic and therapeutic doses on the fertility of female Wistar rats.
abstract: OBJECTIVE
  To evaluate the effects of exposure of enoxaparin and unfractionated heparin (UFH) in prophylactic and therapeutic doses on the fertility rates of pregnant healthy Wistar rats.
  
  
  METHODS
  Enoxaparin and UFH were administered in prophylactic doses 1 mg/Kg/day 72 UI/Kg/day, and in therapeutic doses at 2 mg/kg/day 400UI/Kg/day. The rats were divided into five groups. The number of live and dead foetuses was quantified. The uterine horns were dissected and the presence of early and late reabsorptions (abortions) was determined. A p<0.05 was considered statistically significant.
  
  
  RESULTS
  We did not observe statistically significant differences between groups when comparing the average weight of the foetuses and placentas, rate of female VS males, rates of pre-implantation loss (RPL), rates of efficiency implantation (REI), rates of post-implantation loss (RPIL) and rates of foetal viability (RFV).
  
  
  CONCLUSIONS
  There was no significant effect on fertility with the use of anticoagulant drugs in pregnant healthy Wistar rats.
authors: Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.
authors: Ernesto Antonio
authors: EA
authors: Figueiró-Filho
authors: FAMED, UFMS, Campo Grande, MS, Brazil.
authors: Ricardo Dutra
authors: RD
authors: Aydos
authors: FAMED, UFMS, Campo Grande, MS, Brazil.
authors: Flávio Renato de Almeida
authors: FR
authors: Senefonte
authors: FAMED, UFMS, Campo Grande, MS, Brazil.
authors: Cristiane Munaretto
authors: CM
authors: Ferreira
authors: FAMED, UFMS, Campo Grande, MS, Brazil.
authors: Erica Freire de Vasconcelos
authors: EF
authors: Pereira
authors: FAMED, UFMS, Campo Grande, MS, Brazil.
authors: Vanessa Marcon de
authors: VM
authors: Oliveira
authors: FAMED, UFMS, Campo Grande, MS, Brazil.
authors: Giovanna Pádoa de
authors: GP
authors: Menezes
authors: FAMED, UFMS, Campo Grande, MS, Brazil.
authors: Marco Antonio Costa
authors: MA
authors: Bósio
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000008:administration & dosage* / Q000009:adverse effects; D017984:Enoxaparin / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D005298:Fertility / Q000187:drug effects*; D005333:Fetus / Q000187:drug effects; D006470:Hemorrhage / Q000139:chemically induced; D006493:Heparin / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D010920:Placenta / Q000187:drug effects; D011247:Pregnancy; D011897:Random Allocation; D017208:Rats, Wistar; D012016:Reference Values; D013923:Thromboembolism / Q000188:drug therapy; D013997:Time Factors
chemical_list: D000925:Anticoagulants; D017984:Enoxaparin; D006493:Heparin