title: Intra-periaqueductal gray infusion of zeta inhibitory peptide attenuates pain-conditioned place avoidance in rats.
abstract: Pain is a complex experience that made up of sensory, emotional and cognitive dimensions, and the emotional factors have an important influence on intensity of pain perception. The role of periaqueductal gray (PAG) in sensory component of pain has been extensively studied, while data about pain affect are quite limited. Using formalin-induced conditioned place avoidance (F-CPA) test and inflammatory pain model, present study investigated the effect of intra-PAG infusion of zeta inhibitory peptide (ZIP) on noxious stimulation induced aversion, and the sensory component of pain. Intra-PAG injection of ZIP is sufficient to disrupt pain-induced aversion, but the ZIP infusion did not change inflammation induced pain hypersensitivity in rats. These findings suggest that PAG contributes to pain-related aversion in rats, and the mechanism of pain emotion encoding in PAG may attribute to the activation of targets of ZIP.
authors: Department of Anesthesia, Hangzhou Hospital Affiliated to Nanjing Medical University, Hangzhou First People׳s Hospital, Hangzhou 310006, PR China.
authors: Jianliang
authors: J
authors: Sun
authors: Department of Anesthesia, Ningbo Second Hospital, Ningbo 315000, PR China.
authors: Bo
authors: B
authors: Lu
authors: Department of Anesthesia, Second Affiliated Hospital and Yuying Children Hospital of Wenzhou Medical University, Wenzhou 325000, PR China.
authors: Juan
authors: J
authors: Yao
authors: Department of Anesthesia, Second Affiliated Hospital and Yuying Children Hospital of Wenzhou Medical University, Wenzhou 325000, PR China.
authors: Weiping
authors: W
authors: Lei
authors: Department of Anesthesia, Second Affiliated Hospital and Yuying Children Hospital of Wenzhou Medical University, Wenzhou 325000, PR China.
authors: Yaqin
authors: Y
authors: Huang
authors: Department of Anesthesia, Hangzhou Hospital Affiliated to Nanjing Medical University, Hangzhou First People׳s Hospital, Hangzhou 310006, PR China.
authors: Honghai
authors: H
authors: Zhang
authors: Department of Anesthesia, Hangzhou Hospital Affiliated to Nanjing Medical University, Hangzhou First People׳s Hospital, Hangzhou 310006, PR China; Department of Anesthesia, Jiaxing First Hospital, Jiaxing 314000, PR China. Electronic address: xiaochunmz@gmail.com.
authors: Chun
authors: C
authors: Xiao
mesh_terms: D000700:Analgesics / Q000008:administration & dosage*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects* / Q000502:physiology; D057846:Cell-Penetrating Peptides; D003213:Conditioning, Psychological / Q000187:drug effects / Q000502:physiology; D004195:Disease Models, Animal; D005557:Formaldehyde; D005620:Freund's Adjuvant; D006930:Hyperalgesia / Q000188:drug therapy / Q000503:physiopathology; D055666:Lipopeptides / Q000008:administration & dosage*; D008297:Male; D015213:Neuroimmunomodulation / Q000187:drug effects / Q000502:physiology; D010146:Pain / Q000188:drug therapy* / Q000503:physiopathology; D010147:Pain Measurement; D010487:Periaqueductal Gray / Q000187:drug effects* / Q000503:physiopathology; D017207:Rats, Sprague-Dawley; D013028:Space Perception / Q000187:drug effects* / Q000502:physiology
chemical_list: D000700:Analgesics; D057846:Cell-Penetrating Peptides; D055666:Lipopeptides; C568285:zeta-inhibitory peptide; D005557:Formaldehyde; D005620:Freund's Adjuvant
keywords: Conditioned place avoidance; Nociceptive behavior; Pain; Periaqueductal gray