title: Chloroquine remains effective for treating Plasmodium vivax malaria in Pursat province, Western Cambodia.
abstract: Chloroquine (CQ) is used to treat Plasmodium vivax malaria in areas where CQ resistance has not been reported. The use of artemisinin (ART)-based combination therapies (ACTs) to treat CQ-sensitive P. vivax infections is effective and convenient but may promote the emergence and worsening of ART resistance in sympatric Plasmodium falciparum populations. Here, we show that CQ effectively treats P. vivax malaria in Pursat Province, western Cambodia, where ART-resistant P. falciparum is highly prevalent and spreading. (This study has been registered at ClinicalTrials.gov under registration no. NCT00663546.).
authors: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
authors: Chanaki
authors: C
authors: Amaratunga
authors: National Center for Parasitology, Entomology, and Malaria Control, Phnom Penh, Cambodia.
authors: Sokunthea
authors: S
authors: Sreng
authors: Sampov Meas Referral Hospital, Pursat, Cambodia.
authors: Sivanna
authors: S
authors: Mao
authors: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
authors: Gregory S
authors: GS
authors: Tullo
authors: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
authors: Jennifer M
authors: JM
authors: Anderson
authors: National Center for Parasitology, Entomology, and Malaria Control, Phnom Penh, Cambodia.
authors: Char Meng
authors: CM
authors: Chuor
authors: National Center for Parasitology, Entomology, and Malaria Control, Phnom Penh, Cambodia.
authors: Seila
authors: S
authors: Suon
authors: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA rfairhurst@niaid.nih.gov.
authors: Rick M
authors: RM
authors: Fairhurst
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology; D037621:Artemisinins / Q000494:pharmacology; D002160:Cambodia; D002738:Chloroquine / Q000494:pharmacology*; D004351:Drug Resistance; D008288:Malaria; D010966:Plasmodium vivax / Q000187:drug effects*
chemical_list: D000890:Anti-Infective Agents; D037621:Artemisinins; D002738:Chloroquine; C031327:artemisinin