title: Total synthesis of callipeltin B and M, peptidyl marine natural products.
abstract: Total synthesis of callipeltins B and M, peptidyl cytotoxic agents isolated from marine sponges, by the combination of Fmoc solid-phase peptide synthesis and cyclization and global deprotection in the solution phase is described. Eight amino acids, including several unusual amino acids, were assembled on a solid support, and effective TFA-mediated deprotection was employed to reach callipeltin M. Callipeltin B was accomplished via the macrolactonization between the side chain of d-aThr and the C-terminus carboxylic acid of protected callipeltin M.
authors: Department of Biochemical Engineering, Graduate School of Science and Technology, Yamagata University , Yonezawa, Yamagata 9928510, Japan.
authors: Mari
authors: M
authors: Kikuchi
authors: Hiroyuki
authors: H
authors: Konno
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D000818:Animals; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D008386:Marine Biology; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D011161:Porifera / Q000737:chemistry; D060327:Solid-Phase Synthesis Techniques
chemical_list: D000596:Amino Acids; D001688:Biological Products; D010456:Peptides, Cyclic; C516600:callipeltin B; C000597814:callipeltin M