title: Highly Efficient and Stereoselective Construction of Bispirooxindole Derivatives via a Three-Component 1,3-Dipolar Cycloaddition Reaction.
abstract: A highly regio- and stereoselective synthesis of bispirooxindoles by 1,3-dipolar cycloaddition of in situ generated azomethine ylides from isatin and proline to different electron-deficient alkenes has been developed. The synthesis affords the desired bispiro scaffold compounds in excellent yields with high regioselectivity under mild conditions. The stereochemistry was determined by single-crystal X-ray analysis.
authors: Key Laboratory for Advanced Materials and Institute of Fine Chemicals School of Chemistry & Molecular Engineering East China University of Science and Technology 130 Mei Long Road, Shanghai 200237 (P. R. China).
authors: Qin
authors: Q
authors: Xu
authors: Key Laboratory for Advanced Materials and Institute of Fine Chemicals School of Chemistry & Molecular Engineering East China University of Science and Technology 130 Mei Long Road, Shanghai 200237 (P. R. China).
authors: De
authors: D
authors: Wang
authors: State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences 345 Lingling Road, Shanghai 200032 (P. R. China) E-mail: Mshi@mail.sioc.ac.cn.
authors: Yin
authors: Y
authors: Wei
authors: Key Laboratory for Advanced Materials and Institute of Fine Chemicals School of Chemistry & Molecular Engineering East China University of Science and Technology 130 Mei Long Road, Shanghai 200237 (P. R. China) ; State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences 345 Lingling Road, Shanghai 200032 (P. R. China) E-mail: Mshi@mail.sioc.ac.cn.
authors: Min
authors: M
authors: Shi
keywords: azomethine ylides; bispirooxindoles; cycloaddition; stereochemistry; substituted olefins