title: [Polyvalent meningococcal vaccines: within or outside our agenda?].
abstract: The development of tetravalent vaccines against Invasive Meningococcal Disease (IMD) has been driven mainly due to the increase of the prevalence and geographic expansion of several serogroups considered unusual, but also because of the need for vaccines that offer broad spectrum protection in a devastating disease such as IMD. These changes in serogroups considered usual (B and C) have been detected for both serogroup Y and W, which has led to the multivalent vaccines being used by a number of countries with different strategies that will be discussed in the article. Epidemiological data in Spain, currently do not justify its use in immunization schedules, but there is a potential risk for the introduction of virulent clones of those uncommon serogroups (Y and W), and this would lead us to open a discussion of their potential use, particularly in the adolescent/pre-teen population as a target group for intervention.
authors: Laboratorio Nacional de Referencia de Neissserias, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, España.
authors: R
authors: R
authors: Abad
authors: Laboratorio Nacional de Referencia de Neissserias, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, España. Electronic address: jvazquez@isciii.es.
authors: J A
authors: JA
authors: Vázquez
mesh_terms: D000293:Adolescent; D002648:Child; D006801:Humans; D008589:Meningococcal Infections / Q000517:prevention & control*; D022401:Meningococcal Vaccines; D013030:Spain; D014611:Vaccination / Q000592:standards
chemical_list: D022401:Meningococcal Vaccines
keywords: Changing epidemiology; Enfermedad meningocócica; Epidemiología cambiante; Meningococcal disease; Polyvalent vaccines; Vacunas tetravalentes