title: Imaging-based diagnosis of autosomal dominant polycystic kidney disease.
abstract: The clinical use of conventional ultrasonography (US) in autosomal dominant polycystic kidney disease (ADPKD) is currently limited by reduced diagnostic sensitivity, especially in at-risk subjects younger than 30 years of age. In this single-center prospective study, we compared the diagnostic performance of MRI with that of high-resolution (HR) US in 126 subjects ages 16-40 years born with a 50% risk of ADPKD who underwent both these renal imaging studies and comprehensive PKD1 and PKD2 mutation screening. Concurrently, 45 healthy control subjects without a family history of ADPKD completed the same imaging protocol. We analyzed 110 at-risk subjects whose disease status was unequivocally defined by molecular testing and 45 unaffected healthy control subjects. Using a total of >10 cysts as a test criterion in subjects younger than 30 years of age, we found that MRI provided both a sensitivity and specificity of 100%. Comparison of our results from HR US with those from a previous study of conventional US using the test criterion of a total of three or more cysts found a higher diagnostic sensitivity (approximately 97% versus approximately 82%) with a slightly decreased specificity (approximately 98% versus 100%) in this study. Similar results were obtained in test subjects between the ages of 30 and 40 years old. These results suggest that MRI is highly sensitive and specific for diagnosis of ADPKD. HR US has the potential to rival the diagnostic performance of MRI but is both center- and operator-dependent.
authors: Division of Nephrology, Department of Medicine and york.pei@uhn.ca.
authors: York
authors: Y
authors: Pei
authors: Division of Nephrology, Department of Medicine and Department of Medicine, Eulji General Hospital, Seoul, South Korea; and.
authors: Young-Hwan
authors: YH
authors: Hwang
authors: Department of Medical Imaging, University Health Network and University of Toronto, Toronto, Ontario, Canada;
authors: John
authors: J
authors: Conklin
authors: Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.
authors: Jamie L
authors: JL
authors: Sundsbak
authors: Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.
authors: Christina M
authors: CM
authors: Heyer
authors: Division of Nephrology, Department of Medicine and.
authors: Winnie
authors: W
authors: Chan
authors: Division of Nephrology, Department of Medicine and.
authors: Kairong
authors: K
authors: Wang
authors: Division of Nephrology, Department of Medicine and.
authors: Ning
authors: N
authors: He
authors: Department of Medical Imaging, University Health Network and University of Toronto, Toronto, Ontario, Canada;
authors: Anand
authors: A
authors: Rattansingh
authors: Department of Medical Imaging, University Health Network and University of Toronto, Toronto, Ontario, Canada;
authors: Mostafa
authors: M
authors: Atri
authors: Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.
authors: Peter C
authors: PC
authors: Harris
authors: Department of Medical Imaging, University Health Network and University of Toronto, Toronto, Ontario, Canada;
authors: Masoom A
authors: MA
authors: Haider
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D016891:Polycystic Kidney, Autosomal Dominant / Q000000981:diagnostic imaging*; D014463:Ultrasonography; D055815:Young Adult
keywords: autosomal dominant polycystic kidney disease; clinical epidemiology; polycystic kidney disease