title: Nanopore back titration analysis of dipicolinic acid.
abstract: Here, we report a novel label-free nanopore back titration method for the detection of dipicolinic acid, a marker molecule for bacterial spores. By competitive binding of the target analyte and a large ligand probe to metal ions, dipicolinic acid could be sensitively and selectively detected. This nanopore back titration approach should find useful applications in the detection of other species of medical, biological, or environmental importance if their direct detection is difficult to achieve.
authors: Department of Biological and Chemical Sciences, Illinois Institute of Technology, Chicago, IL, USA.
authors: Yujing
authors: Y
authors: Han
authors: Shuo
authors: S
authors: Zhou
authors: Liang
authors: L
authors: Wang
authors: Xiyun
authors: X
authors: Guan
mesh_terms: D001431:Bacteriological Techniques / Q000379:methods*; D015415:Biomarkers / Q000032:analysis* / Q000737:chemistry; D058608:Nanopores; D010848:Picolinic Acids / Q000032:analysis* / Q000737:chemistry; D013171:Spores, Bacterial / Q000302:isolation & purification*; D013725:Terbium; D017186:Titrimetry / Q000379:methods*
chemical_list: D015415:Biomarkers; D010848:Picolinic Acids; D013725:Terbium; C004860:dipicolinic acid
keywords: Back titration; Dipicolinic acid; Label-free; Nanopore; Terbium