title: Association of adiponectin and leptin with relative telomere length in seven independent cohorts including 11,448 participants.
abstract: Oxidative stress and inflammation are major contributors to accelerated age-related relative telomere length (RTL) shortening. Both conditions are strongly linked to leptin and adiponectin, the most prominent adipocyte-derived protein hormones. As high leptin levels and low levels of adiponectin have been implicated in inflammation, one expects adiponectin to be positively associated with RTL while leptin should be negatively associated. Within the ENGAGE consortium, we investigated the association of RTL with adiponectin and leptin in seven independent cohorts with a total of 11,448 participants. We performed partial correlation analysis on Z-transformed RTL and LN-transformed leptin/adiponectin, adjusting for age and sex. In extended models we adjusted for body mass index (BMI) and C-reactive protein (CRP). Adiponectin showed a borderline significant association with RTL. This appeared to be determined by a single study and when the outlier study was removed, this association disappeared. The association between RTL and leptin was highly significant (r = -0.05; p = 1.81 × 10(-7)). Additional adjustment for BMI or CRP did not change the results. Sex-stratified analysis revealed no difference between men and women. Our study suggests that high leptin levels are associated with short RTL.
authors: Department of Epidemiology, Erasmus University Medical Center, Dr. Molewaterplein 50, PO-Box 2040, 3000 CA, Rotterdam, The Netherlands, l.broer@erasmusmc.nl.
authors: Linda
authors: L
authors: Broer
authors: Julia
authors: J
authors: Raschenberger
authors: Joris
authors: J
authors: Deelen
authors: Massimo
authors: M
authors: Mangino
authors: Veryan
authors: V
authors: Codd
authors: Kirsi H
authors: KH
authors: Pietiläinen
authors: Eva
authors: E
authors: Albrecht
authors: Najaf
authors: N
authors: Amin
authors: Marian
authors: M
authors: Beekman
authors: Anton J M
authors: AJ
authors: de Craen
authors: Christian
authors: C
authors: Gieger
authors: Margot
authors: M
authors: Haun
authors: Peter
authors: P
authors: Henneman
authors: Christian
authors: C
authors: Herder
authors: Iiris
authors: I
authors: Hovatta
authors: Annika
authors: A
authors: Laser
authors: Lyudmyla
authors: L
authors: Kedenko
authors: Wolfgang
authors: W
authors: Koenig
authors: Barbara
authors: B
authors: Kollerits
authors: Eeva
authors: E
authors: Moilanen
authors: Ben A
authors: BA
authors: Oostra
authors: Bernhard
authors: B
authors: Paulweber
authors: Lydia
authors: L
authors: Quaye
authors: Aila
authors: A
authors: Rissanen
authors: Michael
authors: M
authors: Roden
authors: Ida
authors: I
authors: Surakka
authors: Ana M
authors: AM
authors: Valdes
authors: Katriina
authors: K
authors: Vuolteenaho
authors: Barbara
authors: B
authors: Thorand
authors: Ko Willems
authors: KW
authors: van Dijk
authors: Jaakko
authors: J
authors: Kaprio
authors: Tim D
authors: TD
authors: Spector
authors: P Eline
authors: PE
authors: Slagboom
authors: Nilesh J
authors: NJ
authors: Samani
authors: Florian
authors: F
authors: Kronenberg
authors: Cornelia M
authors: CM
authors: van Duijn
authors: Karl-Heinz
authors: KH
authors: Ladwig
mesh_terms: D052242:Adiponectin / Q000097:blood / Q000235:genetics*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007249:Inflammation; D020738:Leptin / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D016615:Telomere / Q000235:genetics*
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D020738:Leptin; D002097:C-Reactive Protein