title: Revisiting 30 years of biofunctionalization and surface chemistry of inorganic nanoparticles for nanomedicine.
abstract: In the last 30 years we have assisted to a massive advance of nanomaterials in material science. Nanomaterials and structures, in addition to their small size, have properties that differ from those of larger bulk materials, making them ideal for a host of novel applications. The spread of nanotechnology in the last years has been due to the improvement of synthesis and characterization methods on the nanoscale, a field rich in new physical phenomena and synthetic opportunities. In fact, the development of functional nanoparticles has progressed exponentially over the past two decades. This work aims to extensively review 30 years of different strategies of surface modification and functionalization of noble metal (gold) nanoparticles, magnetic nanocrystals and semiconductor nanoparticles, such as quantum dots. The aim of this review is not only to provide in-depth insights into the different biofunctionalization and characterization methods, but also to give an overview of possibilities and limitations of the available nanoparticles.
authors: Harvard-MIT Division for Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology Cambridge, MA, USA.
authors: João
authors: J
authors: Conde
authors: Nanotherapy and Nanodiagnostics Group, Instituto de Nanociencia de Aragon, Universidad de Zaragoza Zaragoza, Spain.
authors: Jorge T
authors: JT
authors: Dias
authors: Nanotherapy and Nanodiagnostics Group, Instituto de Nanociencia de Aragon, Universidad de Zaragoza Zaragoza, Spain.
authors: Valeria
authors: V
authors: Grazú
authors: Nanotherapy and Nanodiagnostics Group, Instituto de Nanociencia de Aragon, Universidad de Zaragoza Zaragoza, Spain.
authors: Maria
authors: M
authors: Moros
authors: CIGMH, Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa Caparica, Portugal.
authors: Pedro V
authors: PV
authors: Baptista
authors: Nanotherapy and Nanodiagnostics Group, Instituto de Nanociencia de Aragon, Universidad de Zaragoza Zaragoza, Spain ; Fundacion ARAID Zaragoza, Spain ; Key Laboratory for Thin Film and Microfabrication Technology of the Ministry of Education, Department of Bio-Nano Science and Engineering, Institute of Nano Biomedicine and Engineering, Research Institute of Translation Medicine, Shanghai Jiao Tong University Shanghai, China.
authors: Jesus M
authors: JM
authors: de la Fuente
keywords: biofunctionalization; chemistry surface; gold nanoparticles; magnetic nanoparticles; quantum dots