title: Rethinking the role of myeloid-derived suppressor cells in adoptive T-cell therapy for cancer.
abstract: The expansion of cancer-induced myeloid cells is thought to be one of the main obstacles to successful immunotherapy. Nevertheless, in murine tumors undergoing immune-mediated destruction by adoptively transferred T cells, we have recently shown that such cells maintain their immunosuppressive properties. Therefore, adoptive T-cell therapy can, under certain conditions, overcome myeloid cell immunosuppression.
authors: Department of Pathology; The University of Chicago; Chicago, IL USA.
authors: Ainhoa
authors: A
authors: Arina
keywords: adoptive T-cell therapy; cancer; immunosuppression; myeloid derived-suppressor cells; tumor-associated macrophages