title: DABCO-catalyzed ring opening of activated cyclopropanes and recyclization leading to γ-lactams with an all-carbon quaternary center.
abstract: A novel and efficient method for the construction of γ-lactams with an all-carbon quaternary center is developed via a DABCO-catalyzed reaction of EWG-activated cyclopropanecarboxamides and electron-deficient alkenes. The process involves sequential ring-opening of activated cyclopropanes, intermolecular Michael addition and intramolecular aza-cyclization.
authors: Department of Chemistry, Northeast Normal University, Changchun 130024, China. liangfs112@nenu.edu.cn.
authors: Shaoxia
authors: S
authors: Lin
authors: Ling
authors: L
authors: Li
authors: Fushun
authors: F
authors: Liang
authors: Qun
authors: Q
authors: Liu
mesh_terms: D000181:Acrylonitrile / Q000737:chemistry; D000577:Amides / Q000737:chemistry*; D001372:Aza Compounds / Q000737:chemistry; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D018360:Crystallography, X-Ray; D003500:Cyclization; D003521:Cyclopropanes / Q000737:chemistry*; D007769:Lactams / Q000737:chemistry*; D008968:Molecular Conformation; D010879:Piperazines / Q000737:chemistry*
chemical_list: D000577:Amides; D001372:Aza Compounds; D003521:Cyclopropanes; D007769:Lactams; D010879:Piperazines; D002244:Carbon; D000181:Acrylonitrile; C538819:cyclopropanecarboxamide; C007306:triethylenediamine