title: Divergent chemo-, regio-, and diastereoselective normal electron-demand Povarov-type reactions with α-oxo-ketene dienophiles.
abstract: The reactions between electron-rich 2-aza-dienes and α-oxo-ketenes derived from the Wolff rearrangement of 2-diazocycloalkane-1,3-diones chemo- and regioselectively produced spiro hydropyrid-4-ones with good to excellent diastereoselectivities. These reactions are likely to proceed via a domino Wolff/Friedel-Crafts/intramolecular Mannich process. Prolonged domino sequences also allowed the expeditious preparation of a series of pyrazolopyridine and pyridopyrimidine heterocycles.
authors: Departamento de Química, Universidad del Valle , A.A. 25360, Cali, Colombia.
authors: Jaime
authors: J
authors: Galvez
authors: Juan-Carlos
authors: JC
authors: Castillo
authors: Jairo
authors: J
authors: Quiroga
authors: Michel
authors: M
authors: Rajzmann
authors: Jean
authors: J
authors: Rodriguez
authors: Yoann
authors: Y
authors: Coquerel