title: Ligand-free MCR for linking quinoxaline framework with a benzimidazole nucleus: a new strategy for the identification of novel hybrid molecules as potential inducers of apoptosis.
abstract: We report a true MCR involving the reaction of N-(prop-2-ynyl)quinoxalin-2-amine derivatives with 2-iodoanilines and tosyl azide in the presence of 10 mol% of CuI and Et3N in DMSO to afford the pre-designed hybrid molecules containing quinoxaline framework linked with a benzimidazole nucleus. The MCR proceeds in the absence of any ligand and/or lateral addition of the catalyst/base affording products within 30 min in good yields, some of which showed encouraging apoptosis inducing properties in zebrafish.
authors: Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India. manojitpal@rediffmail.com.
authors: Rajnikanth
authors: R
authors: Sunke
authors: P Vijaya
authors: PV
authors: Babu
authors: Swapna
authors: S
authors: Yellanki
authors: Raghavender
authors: R
authors: Medishetti
authors: Pushkar
authors: P
authors: Kulkarni
authors: Manojit
authors: M
authors: Pal
mesh_terms: D000818:Animals; D017209:Apoptosis; D001562:Benzimidazoles / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D005021:Ethylamines / Q000737:chemistry; D006801:Humans; D007454:Iodides / Q000737:chemistry; D008024:Ligands; D008856:Microscopy, Fluorescence; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D011810:Quinoxalines / Q000737:chemistry*; D015027:Zebrafish
chemical_list: D001562:Benzimidazoles; D005021:Ethylamines; D007454:Iodides; D008024:Ligands; D011810:Quinoxalines; D003300:Copper; C073870:cuprous iodide; C016162:triethylamine