title: Primary diffuse large B-cell lymphoma of the uterus: case report and review.
abstract: BACKGROUND
  Primary diffuse large B-cell lymphoma of the cervix is a very rare disease, with non-specific clinical presentation. Its prognosis depends on accurate and timely diagnosis and therapy. Moreover, the management of this tumour has never been standardized.
  
  
  METHODS
  Herein we present a rare case of primary diffuse large B-cell lymphoma of the cervix misdiagnosed as cervical myoma. Our systematic review of the English literature identified 143 cases of primary diffuse large B-cell lymphoma of the uterus. Patients' characteristics and oncological, surgical, and safety data were recorded and analyzed.
  
  
  CONCLUSIONS
  Although rare, primary diffuse large B-cell lymphoma of the cervix should never be ruled-out. Given its non-specific clinical symptoms, a multidisciplinary approach is required to perform a timely diagnosis and administer appropriate therapy. Immunochemotherapy (Rituximab + CHOP or CHOP-like regimen) with/without radiotherapy is the most common and most effective treatment; surgery should be avoided.
authors: Unit of Obstetrics and Gynaecology, IRCCS-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy dariomandato@virgilio.it.
authors: Vincenzo Dario
authors: VD
authors: Mandato
authors: Unit of Obstetrics and Gynaecology, IRCCS-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
authors: Rosalba
authors: R
authors: Palermo
authors: Unit of Obstetrics and Gynaecology, IRCCS-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
authors: Angela
authors: A
authors: Falbo
authors: Unit of Haematology, IRCCS-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
authors: Isabella
authors: I
authors: Capodanno
authors: Unit of Obstetrics and Gynaecology, IRCCS-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
authors: Francesco
authors: F
authors: Capodanno
authors: Unit of Pathology, IRCCS-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
authors: Maria Carolina
authors: MC
authors: Gelli
authors: Unit of Obstetrics and Gynaecology, IRCCS-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
authors: Lorenzo
authors: L
authors: Aguzzoli
authors: Unit of Obstetrics and Gynaecology, IRCCS-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
authors: Martino
authors: M
authors: Abrate
authors: Unit of Obstetrics and Gynaecology, IRCCS-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy University of Modena e Reggio Emilia, Reggio Emilia, Italy.
authors: Giovanni Battista
authors: GB
authors: La Sala
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology / Q000628:therapy*; D008875:Middle Aged; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000628:therapy*
keywords: Uterus; cervix; diagnosis; lymphoma; treatment; vaginal bleeding