title: Estimation of pro-renin as a prognostic marker for renal function in PUV patients.
abstract: OBJECTIVE
  To estimate serum pro-renin, and its clinical significance, as a marker of chronic renal disease in posterior urethral valve (PUV) patients.
  
  
  METHODS
  Forty patients with a PUV that were admitted to the hospital between 2010 and 2012 were reviewed. Twenty age-matched patients who were admitted for other non-urological diseases were selected for control. Clinical parameters, serum creatinine, urea, eGFR (estimated glomerular filtration rate) and serum pro-renin were analysed before and after valve ablation.
  
  
  RESULTS
  Forty patients with PUV were included in the study. Three groups were formed according to age: <1 year, 1-3 years, >3 years. Pro-renin was measured using an ELISA (enzyme linked immunosorbent assay) kit and 'Graph Pad Prism' Software. The Spearman's rho test was used for correlation. Serum pro-renin had a negative correlation with the age group (correlation coefficient -0.395, P-value 0.012), eGFR (correlation coefficient -0.850, P-value<0.001) and follow-up eGFR (correlation coefficient -0.471, P-value 0.002). The pro-renin level correlated positively with serum creatinine at presentation (correlation coefficient 0.671, P-value<0.001), blood urea at initial presentation (correlation coefficient 0.684, P-value<0.001), serum creatinine at follow-up (correlation coefficient 0.546, P-value<0.001) and blood urea at follow-up (correlation 0.603, P-value<0.001).
  
  
  CONCLUSIONS
  Pro-renin measured before PUV repair is associated with renal function three months after surgery.
authors: Department of Paediatric Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India. Electronic address: saritaimsbhu@yahoo.com.
authors: S
authors: S
authors: Chowdhury
authors: Department of Paediatric Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India. Electronic address: gangulybhu@gmail.com.
authors: A N
authors: AN
authors: Gangopadhyay
authors: Department of Paediatric Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India. Electronic address: drspsharmabhu@rediffmail.com.
authors: S P
authors: SP
authors: Sharma
authors: Department of Paediatric Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India. Electronic address: drvijayendrakr@rediffmail.com.
authors: V
authors: V
authors: Kumar
authors: Department of Paediatric Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India. Electronic address: hodps@rediffmail.com.
authors: D K
authors: DK
authors: Gupta
authors: Department of Paediatric Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India. Electronic address: chooramani@yahoo.com.
authors: S C
authors: SC
authors: Gopal
authors: Department of Endocrinology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India. Electronic address: skendocrine@yahoo.com.
authors: S K
authors: SK
authors: Singh
mesh_terms: D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D004792:Enzyme Precursors / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007223:Infant; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D011379:Prognosis; D011446:Prospective Studies; D012083:Renin / Q000097:blood*; D014521:Urethra / Q000002:abnormalities*
chemical_list: D015415:Biomarkers; D004792:Enzyme Precursors; D003404:Creatinine; D012083:Renin
keywords: CRF (chronic renal failure); PRA (pro-renin activity); Posterior urethral valve ( PUV)