title: A lymph node ratio of 10% is predictive of survival in stage III colon cancer: a French regional study.
abstract: Lymph node ratio (LNR) (positive lymph nodes/sampled lymph nodes) is predictive of survival in colon cancer. The aim of the present study was to validate the LNR as a prognostic factor and to determine the optimum LNR cutoff for distinguishing between "good prognosis" and "poor prognosis" colon cancer patients. From January 2003 to December 2007, patients with TNM stage III colon cancer operated on with at least of 3 years of follow-up and not lost to follow-up were included in this retrospective study. The two primary endpoints were 3-year overall survival (OS) and disease-free survival (DFS) as a function of the LNR groups and the cutoff. One hundred seventy-eight patients were included. There was no correlation between the LNR group and 3-year OS (P=0.06) and a significant correlation between the LNR group and 3-year DFS (P=0.03). The optimal LNR cutoff of 10% was significantly correlated with 3-year OS (P=0.02) and DFS (P=0.02). The LNR was not an accurate prognostic factor when fewer than 12 lymph nodes were sampled. Clarification and simplification of the LNR classification are prerequisites for use of this system in randomized control trials. An LNR of 10% appears to be the optimal cutoff.
authors: 1 Department of Digestive Surgery, Amiens University Hospital, Amiens, France.
authors: Charles
authors: C
authors: Sabbagh
authors: François
authors: F
authors: Mauvais
authors: Cyril
authors: C
authors: Cosse
authors: Lionel
authors: L
authors: Rebibo
authors: Jean-Paul
authors: JP
authors: Joly
authors: Didier
authors: D
authors: Dromer
authors: Christine
authors: C
authors: Aubert
authors: Sophie
authors: S
authors: Carton
authors: Bernard
authors: B
authors: Dron
authors: Innocenti
authors: I
authors: Dadamessi
authors: Bernard
authors: B
authors: Maes
authors: Guillaume
authors: G
authors: Perrier
authors: David
authors: D
authors: Manaouil
authors: Jean-François
authors: JF
authors: Fontaine
authors: Michel
authors: M
authors: Gozy
authors: Xavier
authors: X
authors: Panis
authors: Pierre Henri
authors: PH
authors: Foncelle
authors: Hugues
authors: H
authors: de Fresnoy
authors: Fabien
authors: F
authors: Leroux
authors: Pierre
authors: P
authors: Vaneslander
authors: Caroline
authors: C
authors: Ghighi
authors: Jean-Marc
authors: JM
authors: Regimbeau
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003110:Colonic Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D015996:Survival Rate
keywords: Colon cancer; Lymph node ratio; Surgery; Survival