title: Mechanosensors in integrin signaling: the emerging role of p130Cas.
abstract: Physicochemical interactions between the cell and its environment are crucial for morphogenesis, tissue homeostasis, remodeling and pathogenesis. Cells form specialized structures like focal adhesions and podosomes that are responsible for bi-directional information exchange between the cell and its surroundings. Besides their role in the transmission of regulatory signals, these structures are also involved in mechanosensing and mechanotransduction. In the past few years, many research groups have been trying to elucidate the mechanisms and consequences of the mechanosensitivity of cells. In this review we discuss the role of the integrin pathway in cellular mechanosensing, focusing on primary mechanosensors, molecules that respond to mechanical stress by changing their conformation. We propose mechanisms by which p130Cas is involved in this process, and emphasize the importance of mechanosensing in cell physiology and the development of diseases.
authors: Department of Cell Biology, Faculty of Science, Charles University in Prague, Czech Republic.
authors: Radoslav
authors: R
authors: Janoštiak
authors: Department of Cell Biology, Faculty of Science, Charles University in Prague, Czech Republic.
authors: Andreea Csilla
authors: AC
authors: Pataki
authors: Department of Cell Biology, Faculty of Science, Charles University in Prague, Czech Republic.
authors: Jan
authors: J
authors: Brábek
authors: Department of Cell Biology, Faculty of Science, Charles University in Prague, Czech Republic. Electronic address: rosel@natur.cuni.cz.
authors: Daniel
authors: D
authors: Rösel
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism; D000818:Animals; D022081:Cell Surface Extensions / Q000378:metabolism; D050719:Crk-Associated Substrate Protein / Q000378:metabolism*; D022001:Focal Adhesions / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D013314:Stress, Mechanical
chemical_list: D050719:Crk-Associated Substrate Protein; D016023:Integrins
keywords: Focal adhesions; Integrins; Mechanosensing; Podosomes; p130Cas