title: Renal cell carcinoma metastatic to a pituitary FSH/LH adenoma: case report and review of the literature.
abstract: Abstract Metastases to the pituitary occur more frequently in patients with widespread cancer and mainly involve the posterior lobe. A few cases of metastatic carcinoma to a pituitary adenoma have been described so far. Here, the authors present an additional case of a clear cell renal cell carcinoma (CCRCC) metastatic to a FSH/LH/α-subunit pituitary adenoma and systematically review the literature. Immunohistochemistry and electron microscopy were performed to characterize both neoplastic components at the morphological level. Moreover, it was hypothesized that expression of VEGF and of the corresponding receptor VEGFR1 could be implicated in the development of the carcinomatous metastasis within the adenoma.
authors: Department of Surgical and Morphological Sciences, University of Insubria , Varese , Italy and.
authors: Francesca
authors: F
authors: Magnoli
authors: Giovanna
authors: G
authors: Finzi
authors: Cristina
authors: C
authors: Riva
authors: Carlo
authors: C
authors: Capella
mesh_terms: D000236:Adenoma / Q000473:pathology*; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000556:secondary* / Q000648:ultrastructure; D005260:Female; D005640:Follicle Stimulating Hormone / Q000096:biosynthesis; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000473:pathology*; D007986:Luteinizing Hormone / Q000096:biosynthesis; D046529:Microscopy, Electron, Transmission; D009378:Neoplasms, Multiple Primary / Q000648:ultrastructure*; D010911:Pituitary Neoplasms / Q000473:pathology*
chemical_list: D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
keywords: Clear cell renal cell carcinoma; electron microscopy; metastasis; pituitary adenoma