title: Studying variability in human brain aging in a population-based German cohort-rationale and design of 1000BRAINS.
abstract: The ongoing 1000 brains study (1000BRAINS) is an epidemiological and neuroscientific investigation of structural and functional variability in the human brain during aging. The two recruitment sources are the 10-year follow-up cohort of the German Heinz Nixdorf Recall (HNR) Study, and the HNR MultiGeneration Study cohort, which comprises spouses and offspring of HNR subjects. The HNR is a longitudinal epidemiological investigation of cardiovascular risk factors, with a comprehensive collection of clinical, laboratory, socioeconomic, and environmental data from population-based subjects aged 45-75 years on inclusion. HNR subjects underwent detailed assessments in 2000, 2006, and 2011, and completed annual postal questionnaires on health status. 1000BRAINS accesses these HNR data and applies a separate protocol comprising: neuropsychological tests of attention, memory, executive functions and language; examination of motor skills; ratings of personality, life quality, mood and daily activities; analysis of laboratory and genetic data; and state-of-the-art magnetic resonance imaging (MRI, 3 Tesla) of the brain. The latter includes (i) 3D-T1- and 3D-T2-weighted scans for structural analyses and myelin mapping; (ii) three diffusion imaging sequences optimized for diffusion tensor imaging, high-angular resolution diffusion imaging for detailed fiber tracking and for diffusion kurtosis imaging; (iii) resting-state and task-based functional MRI; and (iv) fluid-attenuated inversion recovery and MR angiography for the detection of vascular lesions and the mapping of white matter lesions. The unique design of 1000BRAINS allows: (i) comprehensive investigation of various influences including genetics, environment and health status on variability in brain structure and function during aging; and (ii) identification of the impact of selected influencing factors on specific cognitive subsystems and their anatomical correlates.
authors: Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich Jülich, Germany.
authors: Svenja
authors: S
authors: Caspers
authors: Institute of Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen Essen, Germany.
authors: Susanne
authors: S
authors: Moebus
authors: Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich Jülich, Germany.
authors: Silke
authors: S
authors: Lux
authors: Institute of Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen Essen, Germany.
authors: Noreen
authors: N
authors: Pundt
authors: Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich Jülich, Germany.
authors: Holger
authors: H
authors: Schütz
authors: Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich Jülich, Germany ; Department of Genomics, Life & Brain Center, University of Bonn Bonn, Germany ; Institute of Human Genetics, University of Bonn Bonn, Germany.
authors: Thomas W
authors: TW
authors: Mühleisen
authors: Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich Jülich, Germany.
authors: Vincent
authors: V
authors: Gras
authors: Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich Jülich, Germany ; Institute for Clinical Neuroscience and Medical Psychology, University of Düsseldorf Düsseldorf, Germany.
authors: Simon B
authors: SB
authors: Eickhoff
authors: Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich Jülich, Germany.
authors: Sandro
authors: S
authors: Romanzetti
authors: Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich Jülich, Germany.
authors: Tony
authors: T
authors: Stöcker
authors: Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich Jülich, Germany.
authors: Rüdiger
authors: R
authors: Stirnberg
authors: Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich Jülich, Germany.
authors: Mehmet E
authors: ME
authors: Kirlangic
authors: Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich Jülich, Germany.
authors: Martina
authors: M
authors: Minnerop
authors: Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich Jülich, Germany.
authors: Peter
authors: P
authors: Pieperhoff
authors: Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich Jülich, Germany.
authors: Ulrich
authors: U
authors: Mödder
authors: McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University Montreal, QC, Canada.
authors: Samir
authors: S
authors: Das
authors: McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University Montreal, QC, Canada.
authors: Alan C
authors: AC
authors: Evans
authors: Institute of Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen Essen, Germany.
authors: Karl-Heinz
authors: KH
authors: Jöckel
authors: Department of Cardiology, University of Duisburg-Essen Essen, Germany.
authors: Raimund
authors: R
authors: Erbel
authors: Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich Jülich, Germany ; Department of Genomics, Life & Brain Center, University of Bonn Bonn, Germany ; Institute of Human Genetics, University of Bonn Bonn, Germany ; Division of Medical Genetics, Department of Biomedicine, University of Basel Basel, Switzerland.
authors: Sven
authors: S
authors: Cichon
authors: Department of Genomics, Life & Brain Center, University of Bonn Bonn, Germany ; Institute of Human Genetics, University of Bonn Bonn, Germany.
authors: Markus M
authors: MM
authors: Nöthen
authors: Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich Jülich, Germany ; Institute for Science and Ethics, University of Bonn Bonn, Germany.
authors: Dieter
authors: D
authors: Sturma
authors: Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich Jülich, Germany ; Department of Neurology, Heinrich-Heine-University Düsseldorf Düsseldorf, Germany.
authors: Andreas
authors: A
authors: Bauer
authors: Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich Jülich, Germany ; JARA-BRAIN, Jülich-Aachen Research Alliance Jülich, Germany ; Department of Neurology, RWTH Aachen University Aachen, Germany.
authors: N
authors: N
authors: Jon Shah
authors: Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich Jülich, Germany ; JARA-BRAIN, Jülich-Aachen Research Alliance Jülich, Germany ; Department of Psychiatry, Psychotherapy, and Psychosomatics, RWTH Aachen University Aachen, Germany.
authors: Karl
authors: K
authors: Zilles
authors: Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich Jülich, Germany ; JARA-BRAIN, Jülich-Aachen Research Alliance Jülich, Germany ; C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf Düsseldorf, Germany.
authors: Katrin
authors: K
authors: Amunts
keywords: Heinz Nixdorf Recall Study; aging; cohort; connectivity; elderly; imaging genetics; resting-state; variability