title: Attenuation of the contingency detection effect in the extrastriate body area in autism spectrum disorder.
abstract: Detection of the contingency between one's own behavior and consequent social events is important for normal social development, and impaired contingency detection may be a cause of autism spectrum disorder (ASD). To depict the neural underpinnings of this contingency effect, 19 adults with ASD and 22 control participants underwent functional MRI while imitating another's actions and their actions being imitated by the other. As the extrastriate body area (EBA) receives efference copies of one's own movements, we predicted that the EBA would show an atypical response during contingency detection in ASD. We manipulated two factors: the congruency of the executed and observed actions, and the order of action execution and observation. Both groups showed the congruency effect in the bilateral EBA during imitation. When action preceded observation, the left EBA of the control group showed the congruency effect, representing the response to being imitated, indicating contingency detection. The ASD group showed a reduced contingency effect in the left EBA. These results indicate that the function of the EBA in the contingency detection is altered in ASD.
authors: Division of Cerebral Integration, Department of Cerebral Research, National Institute for Physiological Sciences, Japan; Department of Physiological Sciences, The Graduate University for Advanced Studies (Sokendai), Japan; Department of Education, Faculty of Regional Sciences, Tottori University, Japan.
authors: Yuko
authors: Y
authors: Okamoto
authors: Division of Cerebral Integration, Department of Cerebral Research, National Institute for Physiological Sciences, Japan; Department of Physiological Sciences, The Graduate University for Advanced Studies (Sokendai), Japan.
authors: Ryo
authors: R
authors: Kitada
authors: Division of Cerebral Integration, Department of Cerebral Research, National Institute for Physiological Sciences, Japan; Department of Social and Human Environment, Graduate School of Environmental Studies, Nagoya University, Japan.
authors: Hiroki C
authors: HC
authors: Tanabe
authors: Division of Cerebral Integration, Department of Cerebral Research, National Institute for Physiological Sciences, Japan; Department of Physiological Sciences, The Graduate University for Advanced Studies (Sokendai), Japan; Institute of Biomedicine, Physiology, University of Helsinki, Finland; Brain Research Unit, O.V. Lounasmaa Laboratory, Aalto University School of Science, Finland.
authors: Masamichi J
authors: MJ
authors: Hayashi
authors: Advanced Telecommunications Research Institute International, Brain Activity Imaging Center, Kyoto, Japan.
authors: Takanori
authors: T
authors: Kochiyama
authors: Research Center for Child Mental Development, Kanazawa University, Japan.
authors: Toshio
authors: T
authors: Munesue
authors: Department of Neuropsychiatry, Faculty of Medical Sciences, University of Fukui, Japan; Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, Japan.
authors: Makoto
authors: M
authors: Ishitobi
authors: Biomedical Imaging Research Center, University of Fukui, Japan; Research and Education Program for Life Science, University of Fukui, Japan; Research Center for Child Mental Development, University of Fukui, Japan.
authors: Daisuke N
authors: DN
authors: Saito
authors: Department of Education, Faculty of Regional Sciences, Tottori University, Japan; Biomedical Imaging Research Center, University of Fukui, Japan; Research and Education Program for Life Science, University of Fukui, Japan.
authors: Hisakazu T
authors: HT
authors: Yanaka
authors: Faculty of Nursing and Social Welfare Sciences, Fukui Prefectural University, Japan.
authors: Masao
authors: M
authors: Omori
authors: Department of Neuropsychiatry, Faculty of Medical Sciences, University of Fukui, Japan; Research Center for Child Mental Development, University of Fukui, Japan.
authors: Yuji
authors: Y
authors: Wada
authors: Biomedical Imaging Research Center, University of Fukui, Japan; Research and Education Program for Life Science, University of Fukui, Japan; Research Center for Child Mental Development, University of Fukui, Japan.
authors: Hidehiko
authors: H
authors: Okazawa
authors: Division of Cerebral Integration, Department of Cerebral Research, National Institute for Physiological Sciences, Japan; Department of Physiological Sciences, The Graduate University for Advanced Studies (Sokendai), Japan; Department of Physiology, Osaka City University Graduate School of Medicine, Japan; Pathophysiological and Health Science Team, RIKEN Center for Life Science Technologies, Japan.
authors: Akihiro T
authors: AT
authors: Sasaki
authors: Division of Sensori-Motor Integration, Department of Integrative Physiology, National Institute for Physiological Sciences, Japan; Department of Adaptive Machine System, Graduate School of Engineering, Osaka University, Japan.
authors: Tomoyo
authors: T
authors: Morita
authors: Department of Psychology, Graduate School of Letters, Kyoto University, Japan; Advanced Telecommunications Research Institute International, Intelligent Robotics and Communication Laboratories, Japan.
authors: Shoji
authors: S
authors: Itakura
authors: Department of Neuropsychiatry, Faculty of Medical Sciences, University of Fukui, Japan; Biomedical Imaging Research Center, University of Fukui, Japan; Research Center for Child Mental Development, University of Fukui, Japan.
authors: Hirotaka
authors: H
authors: Kosaka
authors: Division of Cerebral Integration, Department of Cerebral Research, National Institute for Physiological Sciences, Japan; Department of Physiological Sciences, The Graduate University for Advanced Studies (Sokendai), Japan; Biomedical Imaging Research Center, University of Fukui, Japan. Electronic address: sadato@nips.ac.jp.
authors: Norihiro
authors: N
authors: Sadato
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology; D001931:Brain Mapping; D002659:Child Development Disorders, Pervasive / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007100:Imitative Behavior / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009778:Occipital Lobe / Q000503:physiopathology*; D011597:Psychomotor Performance / Q000502:physiology; D012649:Self Concept; D012919:Social Behavior; D055815:Young Adult
keywords: Autism spectrum disorders; Being imitated; Extrastriate body area