title: Aortic Stiffness Is Related to the Ischemic Brain Injury Biomarker N-Methyl-D-aspartate Receptor Antibody Levels in Aortic Valve Replacement.
abstract: Background. Aortic stiffness changes the flow pattern of circulating blood causing microvascular damage to different end-organ tissues, such as brain cells. The relationship between aortic stiffness measured by pulse wave velocity (PWV) and serum ischemic brain injury biomarker N-methyl-D-aspartate receptor antibody (NR2Ab) levels in aortic valve replacement has not been assessed. Methods. Patients undergoing aortic valve replacement (AVR) for aortic stenosis (AS) had their PWV and NR2Ab serum levels measured preoperatively. We analyzed PWV and NR2Ab in two ways: (1) as continuous variables using the actual value and (2) as dichotomous variables (PWV-norm and PWV-high groups) and (NR2Ab-low and NR2Ab-high groups). Results. Fifty-six patients (71 ± 8.4 years) were included in this study. The NR2Ab level (ng/mL) was significantly higher in the PWV-high group (n = 21) than in PWV-norm group (n = 35; median 1.8 ± 1.2 versus 1.2 ± 0.7, resp., P = 0.003). NR2Ab level was positively associated with PWV and negatively associated with male gender. Multiple regression revealed PWV independently related to NR2Ab level, and PWV cut-off was associated with a 7.23 times increase in the likelihood of having high NR2Ab (>1.8 ng/mL). Conclusion. Higher PWV in patients with surgical aortic stenosis is associated with higher levels of the ischemic brain biomarker NR2Ab.
authors: Department of Surgery and Cancer, Imperial College London, 10th Floor, QEQM Wing, St Mary's Campus, London W2 1NY, UK.
authors: Emaddin
authors: 0000-0003-1276-6663
authors: E
authors: Kidher
authors: Department of Surgery and Cancer, Imperial College London, 10th Floor, QEQM Wing, St Mary's Campus, London W2 1NY, UK.
authors: Vanash M
authors: VM
authors: Patel
authors: Departments of Cardiac Surgery and Cardiology, Imperial College Healthcare NHS Trust, London W12 0HS, UK.
authors: Petros
authors: P
authors: Nihoyannopoulos
authors: Departments of Cardiac Surgery and Cardiology, Imperial College Healthcare NHS Trust, London W12 0HS, UK.
authors: Jon R
authors: JR
authors: Anderson
authors: Departments of Cardiac Surgery and Cardiology, Imperial College Healthcare NHS Trust, London W12 0HS, UK.
authors: Andrew
authors: A
authors: Chukwuemeka
authors: International Centre for Circulatory Health, Imperial College Healthcare NHS Trust, London W2 1LA, UK.
authors: Darrel P
authors: DP
authors: Francis
authors: Department of Surgery and Cancer, Imperial College London, 10th Floor, QEQM Wing, St Mary's Campus, London W2 1NY, UK.
authors: Hutan
authors: H
authors: Ashrafian
authors: Department of Surgery and Cancer, Imperial College London, 10th Floor, QEQM Wing, St Mary's Campus, London W2 1NY, UK ; Departments of Cardiac Surgery and Cardiology, Imperial College Healthcare NHS Trust, London W12 0HS, UK.
authors: Thanos
authors: T
authors: Athanasiou