title: Predictors of hospital stay and mortality in dengue virus infection-experience from Aga Khan University Hospital Pakistan.
abstract: BACKGROUND
  Dengue virus infection (DVI) is very common infection. There is scarcity of data on factor associated with increased hospital stay and mortality in dengue virus infection (DVI). This study was done to know about factors associated with increased hospital stay and mortality in patients admitted with DVI.
  
  
  RESULTS
  Out of 532 patients, two third (72.6%) had stay ≤3 days while one third (27.4%) had stay greater than 3 days. The mean length of hospital stay was 3.46 ± 3.45 days. Factors associated with increased hospital stay (>3 days) included AKI (acute kidney injury) (Odd ratio 2.98; 95% CI 1.66-5.34), prolonged prothrombin time (Odd ratio 2.03; 95% CI 1.07-3.84), prolonged activated partial thromboplastin time (aPTT) (Odd ratio 1.80; CI 95% 1.15-2.83) and increased age of > 41.10 years (Odd ratio 1.03; CI 95% 1.01-1.04).Mortality was 1.5%. High mortality was found in those with AKI (P <0.01), dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) (P <0.001), respiratory failure (P0.01), prolong PT (P 0.001), prolong aPTT (P0.01) and increased hospital stay (P0.04).
  
  
  CONCLUSIONS
  Increasing age, coagulopathy and acute kidney injury in patients with DVI is associated with increased hospital stay. Morality was more in patients with AKI, DHF and DSS, respiratory failure, coagulopathy and these patients had more prolonged hospitalization.
authors: Department of Medicine, Aga Khan University Hospital, Karachi 74800, Pakistan. doctrokhalil1975@hotmail.com.
authors: Muhammad Abdul Mabood
authors: MA
authors: Khalil
authors: Jackson
authors: J
authors: Tan
authors: Muhammd Ashhad Ullah
authors: MA
authors: Khalil
authors: Safia
authors: S
authors: Awan
authors: Manickam
authors: M
authors: Rangasami
mesh_terms: D000328:Adult; D003715:Dengue / Q000401:mortality*; D003716:Dengue Virus / Q000502:physiology*; D005260:Female; D006785:Hospitals, University / Q000706:statistics & numerical data*; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data*; D008297:Male; D010154:Pakistan / Q000453:epidemiology; D012307:Risk Factors