title: [Impact of the number of lymph nodes dissected on the prognosis of G3 advanced gastric cancer].
abstract: OBJECTIVE
  To explore the risk factors associated with the prognosis in poorly differentiated(G3) advanced gastric cancer (AGC) and the effect of number of harvested lymph nodes on the prognosis.
  
  
  METHODS
  Clinical data of 484 patients with G3 advanced gastric cancer undergoing gastrectomy combined with lymphadenectomy in Zhongshan Hospital from December 2002 to October 2007 were retrospectively analyzed. The χ(2) test or Fisher's exact probability method was used to test measurement data. Survival was calculated using Kaplan-Meier method. Clinicopathological factors such as age, invasion depth, number of harvested lymph nodes, lymph node metastasis, ratio of metastatic lymph node, lymphatic vessels involvement were analyzed using the Cox regression model.
  
  
  RESULTS
  Number of lymph node dissected, lymph node metastasis, ratio of metastatic lymph node and lymphatic vessels involvement were significantly affected by groups of 15 lymph node dissected in G3 AGC patients (P<0.05). Invasion depth, number of lymph node dissected, lymph node metastasis, ratio of metastatic lymph node and lymphatic vessels involvement were significantly independent predictors of survival in G3 AGC patients (all P<0.05). Patients with at least 20 lymph nodes had a better survival rate than those with less than 20(P<0.01).
  
  
  CONCLUSIONS
  Invasion depth, number of harvested lymph nodes, lymph node metastasis, ratio of metastatic lymph node and lymphatic vessels involvement are important factors influencing the prognosis of G3 AGC. At least 20 lymph nodes should be recommended to ensure the quality of lymphadenectomy for gastric cancer.
authors: The Institution of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China. liu.fenglin@zs-hospital.sh.cn.
authors: Jiaqian
authors: J
authors: Ling
authors: Cong
authors: C
authors: Wang
authors: Xuefei
authors: X
authors: Wang
authors: Zhenbin
authors: Z
authors: Shen
authors: Weidong
authors: W
authors: Chen
authors: Jing
authors: J
authors: Qin
authors: Xinyu
authors: X
authors: Qin
authors: Kuntang
authors: K
authors: Shen
authors: Yihong
authors: Y
authors: Sun
authors: Fenglin
authors: F
authors: Liu
mesh_terms: D005743:Gastrectomy; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes; D008207:Lymphatic Metastasis; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery; D015996:Survival Rate