title: The natural history of primary biliary cirrhosis.
abstract: Our understanding of the natural history of primary biliary cirrhosis (PBC) has been evolving especially following the introduction of ursodeoxycholic acid (UDCA). A clearer understanding of disease pathophysiology and earlier diagnosis with increased prevalence of the disease worldwide has led to increased interest and improved outcomes in patients with PBC. In this article, the authors touch briefly on features of the disease and describe the natural history of PBC prior to and after the introduction of UDCA.
authors: Department of Internal Medicine, University of North Dakota, Fargo, North Dakota.
authors: Mohamad H
authors: MH
authors: Imam
authors: College of Health Solutions, Arizona State University, Phoenix, Arizona.
authors: Keith D
authors: KD
authors: Lindor
mesh_terms: D001653:Bile Ducts, Intrahepatic / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D002756:Cholagogues and Choleretics / Q000627:therapeutic use; D018450:Disease Progression; D005260:Female; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology / Q000503:physiopathology / Q000628:therapy; D016031:Liver Transplantation; D008297:Male; D011247:Pregnancy; D013997:Time Factors; D016896:Treatment Outcome; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use
chemical_list: D002756:Cholagogues and Choleretics; D014580:Ursodeoxycholic Acid