title: Measuring residual activity of topical antimicrobials: is the residual activity of chlorhexidine an artefact of laboratory methods?
abstract: Residual activity of chlorhexidine gluconate (CHG) was evaluated by pretreating hands with CHG and then touching Staphylococcus aureus dried on to stainless steel discs. By this method, no reduction in bacteria was observed up to 15 min, suggesting that residual CHG does not offer protection against contamination with transient micro-organisms in clinical practice.
authors: GOJO Industries, Inc., Akron, OH, USA.
authors: J D
authors: JD
authors: Rutter
authors: GOJO Industries, Inc., Akron, OH, USA.
authors: K
authors: K
authors: Angiulo
authors: GOJO Industries, Inc., Akron, OH, USA; Northeastern Medical University, Rootstown, OH, USA. Electronic address: macingad@gojo.com.
authors: D R
authors: DR
authors: Macinga
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D016477:Artifacts; D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006235:Hand Disinfection / Q000379:methods; D006801:Humans; D008875:Middle Aged; D012867:Skin / Q000187:drug effects / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects*; D055815:Young Adult
chemical_list: D000891:Anti-Infective Agents, Local; C010882:chlorhexidine gluconate; D002710:Chlorhexidine
keywords: Chlorhexidine; Hand hygiene; Persistence; Residual activity; Residual kill; Transient bacteria