title: Rhenium Complexes with Red-Light-Induced Anticancer Activity.
abstract: Rhenium(I) pyridocarbazole complexes with photoinduced antiproliferative activity are reported. The substitutionally inert complexes induce cell death by singlet oxygen generation upon irradiation with red light (λ≥ 620 nm), while only weak background cytotoxicity is observed in the dark. Due to their ability to inhibit protein kinases (nanomolar IC50values against Pim1 at 10 μM ATP), this class of rhenium complexes point into the direction of dual function antiproliferative therapy with a single drug in which photodynamic therapy is combined with the inhibition of cancer related protein kinases.
authors: Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Straße, 35043 Marburg (Germany).
authors: Kathrin
authors: K
authors: Wähler
authors: Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Straße, 35043 Marburg (Germany).
authors: Anja
authors: A
authors: Ludewig
authors: Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Straße, 35043 Marburg (Germany).
authors: Patrick
authors: P
authors: Szabo
authors: Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Straße, 35043 Marburg (Germany).
authors: Klaus
authors: K
authors: Harms
authors: Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Straße, 35043 Marburg (Germany) ; College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 (P. R. China).
authors: Eric
authors: E
authors: Meggers
keywords: Antiproliferation; Inhibitors; Light; Organometallic Complexes; Rhenium; Singlet Oxygen