title: Retinoblastoma. Fifty years of progress. The LXXI Edward Jackson Memorial Lecture.
abstract: OBJECTIVE
  To review the progress made in understanding the genetic basis, molecular pathology, and treatment of retinoblastoma since the previous Jackson lecture on the topic was published 50 years ago.
  
  
  METHODS
  Perspective based on personal experience and the literature.
  
  
  METHODS
  The literature regarding retinoblastoma was reviewed since 1963. Advances in understanding the biology and treatment of retinoblastoma provided context through the author's clinical, pathologic, and research experiences.
  
  
  RESULTS
  Retinoblastoma was first identified in the 1500s and defined as a unique clinicopathologic entity in 1809. Until the mid-1900s, knowledge advanced sporadically, with technological developments of ophthalmoscopy and light microscopy, and with the introduction of surgical enucleation, chemotherapy, and radiation therapy. During the last 50 years, research and treatment have progressed at an unprecedented rate owing to innovations in molecular biology and the development of targeted therapies. During this time period, the retinoblastoma gene was discovered; techniques for genetic testing for retinoblastoma were developed; and plaque brachytherapy, chemoreduction, intra-arterial chemotherapy, and intraocular injections of chemotherapeutic agents were successfully introduced.
  
  
  CONCLUSIONS
  Nearly all patients with retinoblastoma in developed countries can now be cured of their primary cancer--a remarkable achievement for a childhood cancer that once was uniformly fatal. Much of this success is owed to deciphering the role of the Rb gene, and the benefits of targeted therapies, such as chemoreduction with consolidation as well as intra-arterial and intravitreal chemotherapies. Going forward, the main challenge will be ensuring that access to care is available for all children, particularly those in developing countries.
authors: Departments of Ophthalmology and Pathology, Emory University School of Medicine, Atlanta, Georgia. Electronic address: ophtheg@emory.edu.
authors: Hans E
authors: HE
authors: Grossniklaus
mesh_terms: D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D019572:Retinal Neoplasms / Q000235:genetics / Q000266:history* / Q000473:pathology / Q000628:therapy; D012175:Retinoblastoma / Q000235:genetics / Q000266:history* / Q000473:pathology / Q000628:therapy