title: Enhanced skin delivery of liquiritigenin and liquiritin-loaded liposome-in-hydrogel complex system.
abstract: OBJECTIVE
  To study the permeation of liquiritigenin (LQG) and liquiritin (LQ) as licorice flavonoids into the skin, we prepared ceramide liposome-in-cellulose hydrogel complex system.
  
  
  METHODS
  Liposome-in-hydrogel complex systems were developed by incorporating ceramide liposomes into cellulose hydrogels by the swelling method. We evaluated their physical and chemical properties, encapsulation efficiency and skin permeability using Franz Diffusion Cell. It was visually seen by CLSM images analysis.
  
  
  RESULTS
  The ceramide liposome, consisting of biocompatible lipid membranes, remained stable for over 3 weeks. Encapsulation efficiencies for liquiritigenin and liquiritin-loaded liposome-in-hydrogel were 69.39% and 64.71%, respectively. Liposome-in-hydrogel complex systems (LQG: 56.55%, LQ: 66.99%) had greater skin permeability than control (LQG: 4.92%, LQ: 5.30%) or a single liposome systems (LQG: 43.34%, LQ: 48.97%) and hydrogel systems (LQG: 38.21%, LQ: 55.07%).
  
  
  CONCLUSIONS
  Liposome-in-hydrogel system can be a potential drug delivery system for topical delivery of antioxidants such as licorice flavonoids to construct antioxidative skin barrier.
authors: Department of Fine Chemistry, Cosmetic R&D Center, College of Energy and Biotechnology, Seoul National University of Science and Technology, 232, Gongneung-ro, Nowon-gu, Seoul, 137-743, Korea.
authors: S J
authors: SJ
authors: Kim
authors: S S
authors: SS
authors: Kwon
authors: S H
authors: SH
authors: Jeon
authors: E R
authors: ER
authors: Yu
authors: S N
authors: SN
authors: Park
mesh_terms: D000279:Administration, Cutaneous; D016503:Drug Delivery Systems / Q000379:methods*; D004817:Epidermis / Q000502:physiology*; D044950:Flavanones / Q000502:physiology*; D005960:Glucosides; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000008:administration & dosage / Q000494:pharmacology*; D008081:Liposomes / Q000008:administration & dosage / Q000494:pharmacology*; D018613:Microscopy, Confocal; D010539:Permeability
chemical_list: D044950:Flavanones; D005960:Glucosides; D008081:Liposomes; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; C512196:liquiritin; C083152:liquiritigenin
keywords: cellulose hydrogel; ceramide liposome; liquiritigenin; liquiritin; skin permeation