title: Spontaneous unilateral renal dysplasia in a clinically healthy cynomolgus monkey (Macaca fascicularis).
abstract: Renal dysplasia is a congenital renal malformation characterized by disruption of normal renal development with asynchronous differentiation of nephrons, collecting ducts, and parenchyma and abnormal patterning of cortical and medullary tissues. The present article describes unilateral renal dysplasia discovered in a cynomolgus monkey from a routine toxicology study. The affected kidney was small and characterized by extensive interstitial fibrosis with the formation of fibromuscular collars around glomeruli and tubules, immature nephrons, and persistent mesenchyme encompassing few collecting ducts. The present case is remarkable in that there is a paucity of reports describing histopathologic findings of spontaneously occurring renal dysplasia in preclinical test species for use in large animal toxicity studies.
authors: Drug Safety Research and Development, Pfizer Worldwide Research & Development, Groton, CT, USA. Electronic address: norimitsu.shirai@pfizer.com.
authors: Norimitsu
authors: N
authors: Shirai
authors: Drug Safety Research and Development, Pfizer Worldwide Research & Development, Groton, CT, USA.
authors: Kathleen B
authors: KB
authors: Muravnick
authors: Drug Safety Research and Development, Pfizer Worldwide Research & Development, Groton, CT, USA.
authors: Daniel J
authors: DJ
authors: Lettiere
authors: Drug Safety Research and Development, Pfizer Worldwide Research & Development, San Diego, CA, USA.
authors: Mark
authors: M
authors: Evans
mesh_terms: D000818:Animals; D007674:Kidney Diseases / Q000151:congenital* / Q000473:pathology* / Q000662:veterinary*; D008252:Macaca fascicularis; D008297:Male; D008992:Monkey Diseases / Q000151:congenital* / Q000473:pathology
keywords: Cynomolgus monkey; Dysplasia; Histopathology; Kidney