title: Temporally-patterned deep brain stimulation in a mouse model of multiple traumatic brain injury.
abstract: We report that mice with closed-head multiple traumatic brain injury (TBI) show a decrease in the motoric aspects of generalized arousal, as measured by automated, quantitative behavioral assays. Further, we found that temporally-patterned deep brain stimulation (DBS) can increase generalized arousal and spontaneous motor activity in this mouse model of TBI. This arousal increase is input-pattern-dependent, as changing the temporal pattern of DBS can modulate its effect on motor activity. Finally, an extensive examination of mouse behavioral capacities, looking for deficits in this model of TBI, suggest that the strongest effects of TBI in this model are found in the initiation of any kind of movement.
authors: Laboratory of Neurobiology and Behavior, Rockefeller University, 1230 York Ave, Box 275, New York, NY 10065, United States. Electronic address: itabansky@rockefeller.edu.
authors: Inna
authors: I
authors: Tabansky
authors: Laboratory of Neurobiology and Behavior, Rockefeller University, 1230 York Ave, Box 275, New York, NY 10065, United States.
authors: Amy Wells
authors: AW
authors: Quinkert
authors: Laboratory of Neurobiology and Behavior, Rockefeller University, 1230 York Ave, Box 275, New York, NY 10065, United States.
authors: Nadera
authors: N
authors: Rahman
authors: Laboratory of Neurobiology and Behavior, Rockefeller University, 1230 York Ave, Box 275, New York, NY 10065, United States.
authors: Salomon Zev
authors: SZ
authors: Muller
authors: Laboratory of Neurobiology and Behavior, Rockefeller University, 1230 York Ave, Box 275, New York, NY 10065, United States; Linkoping University, Faculty of Health Sciences, Hälsouniversitetet Kansliet 581 83 Linköping, Sweden.
authors: Jesper
authors: J
authors: Lofgren
authors: Laboratory of Neurobiology and Behavior, Rockefeller University, 1230 York Ave, Box 275, New York, NY 10065, United States; Linkoping University, Faculty of Health Sciences, Hälsouniversitetet Kansliet 581 83 Linköping, Sweden.
authors: Johan
authors: J
authors: Rudling
authors: Laboratory of Neurobiology and Behavior, Rockefeller University, 1230 York Ave, Box 275, New York, NY 10065, United States.
authors: Alyssa
authors: A
authors: Goodman
authors: Laboratory of Neurobiology and Behavior, Rockefeller University, 1230 York Ave, Box 275, New York, NY 10065, United States.
authors: Yingping
authors: Y
authors: Wang
authors: Laboratory of Neurobiology and Behavior, Rockefeller University, 1230 York Ave, Box 275, New York, NY 10065, United States.
authors: Donald W
authors: DW
authors: Pfaff
mesh_terms: D000818:Animals; D001143:Arousal; D001930:Brain Injuries / Q000503:physiopathology*; D046690:Deep Brain Stimulation / Q000379:methods*; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity; D013788:Thalamus / Q000503:physiopathology; D013997:Time Factors
keywords: Central thalamus; Deep brain stimulation; Generalized arousal; Mouse; Traumatic brain injury