title: Antimetabolites in cataract surgery to prevent failure of a previous trabeculectomy.
abstract: BACKGROUND
  Patients having cataract surgery have often earlier undergone a trabeculectomy for glaucoma. However, cataract surgery may be associated with failure of the previous glaucoma surgery and antimetabolites may be used with cataract surgery to prevent such failure. There is no systematic review on whether antimetabolites with cataract surgery prevent failure of a previous trabeculectomy.
  
  
  OBJECTIVE
  To assess the effects of antimetabolites with cataract surgery on functioning of a previous trabeculectomy.
  
  
  METHODS
  We searched CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register) (2014, Issue 5), Ovid MEDLINE, Ovid MEDLINE In-Process and Other Non-Indexed Citations, Ovid MEDLINE Daily, Ovid OLDMEDLINE (January 1946 to June 2014), EMBASE (January 1980 to June 2014), Latin American and Caribbean Health Sciences Literature Database (LILACS) (January 1982 to June 2014), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com), ClinicalTrials.gov (www.clinicaltrials.gov) and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en). We did not use any date or language restrictions in the electronic searches for trials. We last searched the electronic databases on 10 June 2014. We also searched the Science Citation Index database (July 2013) and reference lists of potentially relevant studies.
  
  
  METHODS
  Randomised controlled trials (RCTs) of antimetabolites with cataract surgery in people with a functioning trabeculectomy.
  
  
  METHODS
  Two review authors independently reviewed the titles and abstracts from the electronic searches. Two review authors independently assessed relevant full-text articles and entered data.
  
  
  RESULTS
  We identified no RCTs to test the effectiveness of antimetabolites with cataract surgery in individuals with the intention of preventing failure of a previous trabeculectomy.
  
  
  CONCLUSIONS
  There are no RCTs of antimetabolites with cataract surgery in people with a functioning trabeculectomy. Appropriately powered RCTs are needed of antimetabolites during cataract surgery in patients with a functioning trabeculectomy.
authors: Department of Family Medicine, Faculty of Medicine, University of Calgary, UCMC, #1707-1632 14th Avenue, Calgary, AB, Canada, T2M 1N7.
authors: Roger E
authors: RE
authors: Thomas
authors: Andrew
authors: A
authors: Crichton
authors: Bennett C
authors: BC
authors: Thomas
mesh_terms: D000963:Antimetabolites / Q000627:therapeutic use*; D002387:Cataract Extraction; D006801:Humans; D014130:Trabeculectomy
chemical_list: D000963:Antimetabolites