title: Risk of head and neck cancer in patients with diabetes mellitus: a retrospective cohort study in Taiwan.
abstract: OBJECTIVE
  An increasing body of evidence suggests that certain types of cancers are more common in people with diabetes mellitus (DM). However, the risk of head and neck cancer (HNC) in patients with DM has seldom been explored.
  
  
  OBJECTIVE
  To examine the risk of HNC in patients with DM.
  
  
  METHODS
  In this retrospective cohort study using Taiwan's Longitudinal Health Insurance Research Database, we compared 89,089 patients newly diagnosed as having DM and controls without DM-related medical claims matched for comorbidities (obesity, coronary artery disease, hyperlipidemia, and hypertension), sex, and age. Patients were assessed from the index date until the end of follow-up on December 31, 2011, or until the patient was censored because of death.
  
  
  METHODS
  The incidence of HNC at the end of 2011.
  
  
  RESULTS
  The incidence of HNC was 1.47 times higher in patients newly diagnosed as having DM than was the risk of a first malignant tumor in the control group (adjusted hazard ratio [AHR], 1.48; 95% CI, 1.31-1.67). The risks of oral cancer (AHR, 1.74; 95% CI, 1.47-2.06), oropharyngeal cancer (AHR, 1.53; 95% CI, 1.01-2.31), and nasopharyngeal carcinoma (AHR, 1.40; 95% CI, 1.03-1.89) were significantly higher in patients with DM than in controls.
  
  
  CONCLUSIONS
  Diabetes is associated with an increased risk of developing HNC. The risks of developing oral cavity cancer, oropharyngeal cancer, and nasopharyngeal carcinoma were significantly higher in patients with DM.
authors: Department of Food and Beverage Services, Tainan University of Technology, Tainan, Taiwan.
authors: Kuo-Shu
authors: KS
authors: Tseng
authors: Department of Molecular and Cell Biology, University of California, Berkeley.
authors: Charlene
authors: C
authors: Lin
authors: Department of Otolaryngology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan4Department of Otolaryngology, Chi Mei Medical Center, Tainan, Taiwan.
authors: Yung-Song
authors: YS
authors: Lin
authors: Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan6Department of Hospital and Health Care Administration, Chia-Nan University of Pharmacy and Science, Tainan, Taiwan.
authors: Shih-Feng
authors: SF
authors: Weng
mesh_terms: D000328:Adult; D000368:Aged; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology*; D005260:Female; D006258:Head and Neck Neoplasms / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000453:epidemiology* / Q000401:mortality; D009303:Nasopharyngeal Neoplasms / Q000453:epidemiology; D057216:Propensity Score; D012189:Retrospective Studies; D016019:Survival Analysis; D013624:Taiwan / Q000453:epidemiology