title: Theobromine enhances absorption of cacao polyphenol in rats.
abstract: Several concentrations of theobromine (TB) and (-)-epicatechin (EC) were coadministered to rats, and plasma EC and its metabolites were determined using ultra-high-performance liquid chromatography-tandem mass spectrometry. It has been demonstrated that TB increases the absorption of EC in a dose-dependent manner. Cocoa powder had a similar effect, and the mechanism involved is not thought to depend on tight junctions.
authors: a Laboratory of Molecular Functions of Food, Division of Food Science and Biotechnology , Graduate School of Agriculture, Kyoto University , Uji , Japan.
authors: Takayuki
authors: T
authors: Yamamoto
authors: Haruya
authors: H
authors: Takahashi
authors: Koichiro
authors: K
authors: Suzuki
authors: Akira
authors: A
authors: Hirano
authors: Masanori
authors: M
authors: Kamei
authors: Tsuyoshi
authors: T
authors: Goto
authors: Nobuyuki
authors: N
authors: Takahashi
authors: Teruo
authors: T
authors: Kawada
mesh_terms: D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D002099:Cacao / Q000737:chemistry*; D002392:Catechin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000493:pharmacokinetics*; D008297:Male; D010936:Plant Extracts / Q000737:chemistry; D059808:Polyphenols / Q000378:metabolism / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D013805:Theobromine / Q000494:pharmacology*
chemical_list: D010936:Plant Extracts; D059808:Polyphenols; D002392:Catechin; C045651:epigallocatechin gallate; D013805:Theobromine
keywords: Caco-2; absorption; cacao polyphenol; rat; theobromine