title: Simultaneous changes of spatial memory and spine density after intrahippocampal administration of fibrillar aβ1-42 to the rat brain.
abstract: Several animal models of Alzheimer's disease have been used in laboratory experiments. Intrahippocampal injection of fibrillar amyloid-beta (fAβ) peptide represents one of the most frequently used models, mimicking Aβ deposits in the brain. In our experiment synthetic fAβ1-42 peptide was administered to rat hippocampus. The effect of the Aβ peptide on spatial memory and dendritic spine density was studied. The fAβ1-42-treated rats showed decreased spatial learning ability measured in Morris water maze (MWM). Simultaneously, fAβ1-42 caused a significant reduction of the dendritic spine density in the rat hippocampus CA1 region. The decrease of learning ability and the loss of spine density were in good correlation. Our results prove that both methods (MWM and dendritic spine density measurement) are suitable for studying Aβ-triggered neurodegeneration processes.
authors: Department of Medical Chemistry, University of Szeged, Dóm tér 8, Szeged 6720, Hungary.
authors: Emőke
authors: E
authors: Borbély
authors: Department of Medical Chemistry, University of Szeged, Dóm tér 8, Szeged 6720, Hungary.
authors: János
authors: J
authors: Horváth
authors: Department of Medical Chemistry, University of Szeged, Dóm tér 8, Szeged 6720, Hungary.
authors: Szabina
authors: 0000-0002-2781-4288
authors: S
authors: Furdan
authors: Department of Medical Chemistry, University of Szeged, Dóm tér 8, Szeged 6720, Hungary.
authors: Zsolt
authors: Z
authors: Bozsó
authors: Department of Medical Chemistry, University of Szeged, Dóm tér 8, Szeged 6720, Hungary.
authors: Botond
authors: B
authors: Penke
authors: Department of Medical Chemistry, University of Szeged, Dóm tér 8, Szeged 6720, Hungary.
authors: Lívia
authors: L
authors: Fülöp
mesh_terms: D000682:Amyloid / Q000187:drug effects / Q000648:ultrastructure; D016229:Amyloid beta-Peptides / Q000008:administration & dosage* / Q000633:toxicity*; D000818:Animals; D056547:CA1 Region, Hippocampal / Q000187:drug effects / Q000502:physiology; D049229:Dendritic Spines / Q000187:drug effects / Q000502:physiology*; D006056:Golgi Apparatus / Q000187:drug effects / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D010446:Peptide Fragments / Q000008:administration & dosage* / Q000633:toxicity*; D017966:Pyramidal Cells / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D017208:Rats, Wistar; D065852:Spatial Memory / Q000187:drug effects*
chemical_list: D000682:Amyloid; D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42)