title: Paclitaxel-coated balloons in refractory nonanastomostic airway stenosis following lung transplantation.
abstract: Airway stenosis represents the commonest airway complication following lung transplantation, affecting between 7% and 18% of patients. Existing treatment options offer limited efficacy and can cause additional patient morbidity. Paclitaxel-coated balloons (PCB) have proved effective in managing postinterventional coronary artery re-stenosis. In a first-in-man study, we evaluated similar PCBs in refractory nonanastomotic airway stenosis in 12 patients. Following a single application, luminal patency was maintained in 50% at 270 days. No significant peri-interventional or early postinterventional complications occurred. Given these encouraging initial findings, further studies appear warranted.
authors: Department of Respiratory Medicine, Hanover Medical School, Hanover, Germany.
authors: M
authors: M
authors: Greer
authors: T
authors: T
authors: Fuehner
authors: G
authors: G
authors: Warnecke
authors: H
authors: H
authors: Noack
authors: T
authors: T
authors: Heilmann
authors: A
authors: A
authors: Haverich
authors: T
authors: T
authors: Welte
authors: J
authors: J
authors: Gottlieb
mesh_terms: D000328:Adult; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D001980:Bronchi / Q000503:physiopathology*; D003251:Constriction, Pathologic / Q000628:therapy*; D005260:Female; D006801:Humans; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel
keywords: Clinical research/practice; comorbidities; complication; lung (allograft) function/dysfunction; lung transplantation/pulmonology