title: Herpes simplex virus 1 counteracts viperin via its virion host shutoff protein UL41.
abstract: The interferon (IFN)-inducible viperin protein restricts a broad range of viruses. However, whether viperin plays a role during herpes simplex virus 1 (HSV-1) infection is poorly understood. In the present study, it was shown for the first time that wild-type (WT) HSV-1 infection couldn't induce viperin production, and ectopically expressed viperin inhibited the replication of UL41-null HSV-1 but not WT viruses. The underlying molecular mechanism is that UL41 counteracts viperin's antiviral activity by reducing its mRNA accumulation.
authors: Soochow University, Institutes of Biology and Medical Sciences, Suzhou, China.
authors: Guanghui
authors: G
authors: Shen
authors: Soochow University, Institutes of Biology and Medical Sciences, Suzhou, China.
authors: Kezhen
authors: K
authors: Wang
authors: Soochow University, Institutes of Biology and Medical Sciences, Suzhou, China.
authors: Shuai
authors: S
authors: Wang
authors: Department of Pathogenic Biology and Immunology, Institute of Immunology and Sino-French Hoffmann Institute, Guangzhou Medical University, Guangzhou, China.
authors: Mingsheng
authors: M
authors: Cai
authors: Department of Pathogenic Biology and Immunology, Institute of Immunology and Sino-French Hoffmann Institute, Guangzhou Medical University, Guangzhou, China.
authors: Mei-li
authors: ML
authors: Li
authors: Soochow University, Institutes of Biology and Medical Sciences, Suzhou, China zheng.alan@hotmail.com.
authors: Chunfu
authors: C
authors: Zheng
mesh_terms: D057809:HEK293 Cells; D018259:Herpesvirus 1, Human / Q000502:physiology*; D006801:Humans; D044925:Oxidoreductases Acting on CH-CH Group Donors; D011506:Proteins / Q000037:antagonists & inhibitors* / Q000502:physiology; D014764:Viral Proteins / Q000502:physiology*; D014779:Virus Replication / Q000502:physiology; D000090123:Viperin Protein
chemical_list: D044925:Oxidoreductases Acting on CH-CH Group Donors; D011506:Proteins; D014764:Viral Proteins; C081688:Ul41 protein, Human herpesvirus 1; C444427:RSAD2 protein, human; D000090123:Viperin Protein