title: SOX18 expression predicts response to platinum-based chemotherapy in ovarian cancer.
abstract: BACKGROUND
  SOX18 is a transcription factor known to be involved in blood and lymphatic vessel, hair follicle development, and wound healing processes. In addition, it has been reported that SOX18 may influence cancer growth. The role of SOX18 expression in ovarian cancer (OC) has not been determined.
  
  
  METHODS
  SOX18 expression was assessed in 85 OC cases using immunohistochemical methods and in ovarian cancer cell lines on the mRNA and protein level.
  
  
  RESULTS
  SOX18 was expressed in cancer cell nuclei as well as the cytoplasm. Higher nuclear SOX18 expression was associated with presence of residual disease following surgical treatment (p=0.0158) and advanced disease stage (p=0.0056). Univariate survival analysis revealed that high SOX18 (p=0.0125) expression, presence of residual disease (p<0.0001) and advanced disease stage (p<0.0324) predicted poor patient outcome.
  
  
  CONCLUSIONS
  SOX18 may be a new predictive marker for OC.
authors: Department of Histology and Embryology, Medical University in Wroclaw, Wroclaw, Poland bartosz.pula@umed.wroc.pl.
authors: Bartosz
authors: B
authors: Pula
authors: Department of Histology and Embryology, Medical University in Wroclaw, Wroclaw, Poland.
authors: Christopher
authors: C
authors: Kobierzycki
authors: Department of Histology and Embryology, Medical University in Wroclaw, Wroclaw, Poland.
authors: Daniel
authors: D
authors: Solinski
authors: Department of Histology and Embryology, Medical University in Wroclaw, Wroclaw, Poland.
authors: Matuesz
authors: M
authors: Olbromski
authors: Department of Gynecologic Oncology, University of Medical Sciences in Poznan, Poznan, Poland.
authors: Ewa
authors: E
authors: Nowak-Markwitz
authors: Department of Gynecologic Oncology, University of Medical Sciences in Poznan, Poznan, Poland.
authors: Marek
authors: M
authors: Spaczynski
authors: Department of Gynecology, University of Medical Sciences in Poznan, Poznan, Poland.
authors: Witold
authors: W
authors: Kedzia
authors: Department of Histology and Embryology, Medical University in Wroclaw, Wroclaw, Poland Department of Histology and Embryology, University of Medical Sciences in Poznan, Poznan, Poland.
authors: Maciej
authors: M
authors: Zabel
authors: Department of Histology and Embryology, Medical University in Wroclaw, Wroclaw, Poland Department of Physiotherapy, University School of Physical Education in Wroclaw, Wroclaw, Poland.
authors: Piotr
authors: P
authors: Dziegiel
mesh_terms: D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D010984:Platinum / Q000627:therapeutic use; D055760:SOXF Transcription Factors / Q000032:analysis / Q000235:genetics / Q000502:physiology*
chemical_list: C095473:SOX18 protein, human; D055760:SOXF Transcription Factors; D010984:Platinum
keywords: Ovarian cancer; SOX18; chemotherapy; prognosis