title: Serum adiponectin and progranulin levels are associated with gallstone disease.
abstract: OBJECTIVE
  Aberrant adipokine serum concentrations are associated with a variety of obesity-related diseases. This study was designed to investigate the putative role of the adipokines adiponectin, chemerin, progranulin, vaspin, fibroblast growth factor 21 (FGF21) and adipocyte fatty acid binding protein (AFABP) in gallstone disease.
  
  
  METHODS
  Serum levels of adiponectin, chemerin, progranulin, vaspin, FGF21 and AFABP of 189 gallstone patients and 833 healthy controls were measured by enzyme-linked immunosorbent assays.
  
  
  RESULTS
  Increased adiponectin levels were nominally associated with lower gallstone risk in women (p=0.036, odds ratio (OR) 0.47, 95% confidence interval (CI) [0.23; 0.95]). Furthermore progranulin serum concentrations in men were significantly elevated in gallstone carriers in comparison to controls (p=0.012, OR 6.1, 95% CI [1.5; 24.9]). Serum levels of chemerin, vaspin, FGF21 and AFABP did not differ between controls and subjects with gallstones.
  
  
  CONCLUSIONS
  Our data further support a protective effect of adiponectin on gallstone risk and suggest a role of progranulin in the pathophysiology of cholelithiasis. Nevertheless, longitudinal data and functional analyses would be required to assess the pathogenetic link between gallstone formation and adipokine serum levels.
authors: IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.
authors: J
authors: J
authors: Breitfeld
authors: Department of Medicine, Division of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany.
authors: R
authors: R
authors: Sandvoss
authors: IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.
authors: D
authors: D
authors: Schleinitz
authors: IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.
authors: Y
authors: Y
authors: Böttcher
authors: IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.
authors: M
authors: M
authors: Fasshauer
authors: IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.
authors: M
authors: M
authors: Blüher
authors: IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.
authors: M
authors: M
authors: Stumvoll
authors: IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.
authors: P
authors: P
authors: Kovacs
authors: Department of Medicine, Division of Gastroenterology, University of Leipzig, Leipzig, Germany.
authors: H
authors: H
authors: Wittenburg
authors: Department of Medicine, Division of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany.
authors: A
authors: A
authors: Tönjes
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D018925:Chemokines / Q000097:blood; D050556:Fatty Acid-Binding Proteins / Q000097:blood; D005260:Female; D005346:Fibroblast Growth Factors / Q000097:blood; D042882:Gallstones / Q000097:blood*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D000077153:Progranulins; D015843:Serpins / Q000097:blood; D012737:Sex Factors
chemical_list: D052242:Adiponectin; D018925:Chemokines; C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins; C492314:GRN protein, human; D036341:Intercellular Signaling Peptides and Proteins; D000077153:Progranulins; C478630:RARRES2 protein, human; C507339:SERPINA12 protein, human; D015843:Serpins; C414620:fibroblast growth factor 21; D005346:Fibroblast Growth Factors