title: [Epigenetic aspects of peptidergic regulation of vascular endothelial cell proliferation during aging].
abstract: Short peptides vesugen and D-7 have stimulated proliferation-associated protein Ki-67 decreased during aging in tissue-specific cell cultures received from young and old animals and in dissociated vascular endothelial cell cultures. Peptides vesugen and D-7 have interacted with promoter region of MKI67 gene coding protein Ki-67 that was obtained using methods of molecular docking. Both peptides have contacted with core promoter 5'-agcctcaaccatcaggaaaacaagagt-3' located in MKI67 gene from -14 to +12 base pairs relative to the transcriptional initiation site through sequence CATC(ENSG00000148773). Thus, vasoprotective effect of peptide vesugen revealed previously in elder people could be realized through epigenetic regulation of Ki-67 gene expression.
authors: V Kh
authors: VKh
authors: Khavinson
authors: S I
authors: SI
authors: Tarnovskaia
authors: N S
authors: NS
authors: Lin'kova
authors: E O
authors: EO
authors: Guton
authors: E V
authors: EV
authors: Elashkina
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000378:metabolism*; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation / Q000187:drug effects; D019394:Ki-67 Antigen / Q000235:genetics*; D009842:Oligopeptides / Q000494:pharmacology*; D010455:Peptides / Q000494:pharmacology; D020011:Protective Agents / Q000494:pharmacology; D051381:Rats
chemical_list: D019394:Ki-67 Antigen; D009842:Oligopeptides; D010455:Peptides; D020011:Protective Agents; C533570:lysyl-glutamyl-aspartic acid