title: Management of patients with ≥4 brain metastases using stereotactic radiosurgery boost after whole brain irradiation.
abstract: OBJECTIVE
  Brain metastases are a prevalent consequence of systemic cancer, and patients suffering from brain metastases usually present with multiple metastatic lesions. An overwhelming majority of the available literature assessing the role of stereotactic radiosurgery in brain metastasis management includes patients with up to 4 metastases. Given the significant benefit of stereotactic radiosurgery for the treatment of 1 to 3 brain metastases, we evaluated the use of stereotactic radiosurgery boost after whole brain irradiation in the management of patients with ≥4 brain metastases.
  
  
  METHODS
  In this retrospective analysis, outcomes of 50 patients who underwent linear accelerator-based stereotactic radiosurgery boost within 4 to 6 weeks of whole brain irradiation for ≥4 brain metastases were assessed in terms of local control, overall survival, primary involved organ, recursive partitioning analysis class and Karnofsky performance status at the time of stereotactic radiosurgery, number of lesions, age, status of the primary cancer (controlled vs uncontrolled), presence of extracranial disease and toxicity.
  
  
  RESULTS
  Fifty patients with ≥4 brain metastases were treated using linear accelerator-based stereotactic radiosurgery boost after whole brain irradiation between April 1998 and April 2013. Mean and median number of intracranial lesions was 6.02 and 6, respectively. Median lesion volume was 10.9 cc (range, 0.05-32.6). Median survival time after radiosurgery was 10.1 months (range, 1-25). Status of the primary cancer (controlled vs uncontrolled), recursive partitioning analysis class, Karnofsky performance status, and extracranial metastasis showed statistically significant correlations with overall survival (P <0.001). Treatment-related side effects after stereotactic radiosurgery included temporary edema (n = 14, 28%), hemiparesis (n = 1, 2%), seizure (n = 1, 2%), leukoencephalopathy (n = 2, 4%), and radiation necrosis (n = 6, 12%).
  
  
  CONCLUSIONS
  Linear accelerator-based stereotactic radiosurgery boost within 4 to 6 weeks after whole brain irradiation proved to be an efficacious and well-tolerated treatment strategy for the management of patients with ≥4 brain metastases in our study.
authors: Ferrat
authors: F
authors: Dincoglan
authors: Omer
authors: O
authors: Sager
authors: Hakan
authors: H
authors: Gamsiz
authors: Bora
authors: B
authors: Uysal
authors: Selcuk
authors: S
authors: Demiral
authors: Kaan
authors: K
authors: Oysul
authors: Sait
authors: S
authors: Sirin
authors: Ayca
authors: A
authors: Caglan
authors: Murat
authors: M
authors: Beyzadeoglu
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000556:secondary* / Q000601:surgery*; D016371:Cranial Irradiation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery / Q000379:methods*; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome