title: [Advance studies of Slit-Robo signal pathway and its roles in ocular neovascularisation].
abstract: The migration and patterning of axons and blood vessels share similar guidance mechanisms. Slits and their Roundabout (Robo) receptors were initially characterized as repulsive guidance cues for neuronal axons and mediate the migration of neuronal precursor cells during neural development. In recent years, the research of Slit/Robo signal pathway on neovascularization has become one of hot topics. This review will focus on the role of Slit/Robo signal pathway in ocular neovascularization to promote the research of Slit/Robo signaling on ophthalmology.
authors: Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Clinical College of Ophthaonology Tianjin Medical University, Tianjin 300020, China.
authors: Yichun
authors: Y
authors: Kong
authors: Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Clinical College of Ophthaonology Tianjin Medical University, Tianjin 300020, China. Email: zkx4260@vip.163.com.
authors: Kanxing
authors: K
authors: Zhao
mesh_terms: D001369:Axons / Q000502:physiology*; D035843:Biomedical Research; D002465:Cell Movement / Q000502:physiology; D005123:Eye / Q000098:blood supply*; D006801:Humans; D009389:Neovascularization, Pathologic; D018919:Neovascularization, Physiologic / Q000502:physiology*; D009419:Nerve Tissue Proteins; D009434:Neural Pathways / Q000196:embryology*; D011971:Receptors, Immunologic; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D009419:Nerve Tissue Proteins; D011971:Receptors, Immunologic