title: [Clinical effectiveness of cytoflavin inclusion in intensive care of patients with combined traumatic brain injury].
abstract: Autors determine the clinical effectiveness of including cytoflavin in intensive care of patients with severe combined traumatic brain injury. A prospective blind randomized controlled study was conducted on two groups involving 101 participants. In group I (58 patients), the intensive care was standard. In group II (43 patients), the intensive care included cytoflavin which was added beginning with the second day of the post-traumatic period. For this purpose, 10 ml of cytoflavin was dissolved in 200 ml of 10% aqueous solution of glucose and was administered intravenously at a speed of 140 drops (7 ml) per minute within 7 days. The use of cytoflavin in complex intensive care of severe combined traumatic brain injury within two days after injury (with the proper correction of blood circulation and respiration) reduced the number of multiple organ dysfunctions, the number is purulent-septic complications, the time of regress in multiple organ dysfunctions, and the reanimation period in intensive care department on the average by a factor of 1.4 - 1.6 (p < 0.005).
authors: E A
authors: EA
authors: Lebedeva
authors: A A
authors: AA
authors: Kurtasov
authors: M E
authors: ME
authors: Belousova
authors: Z A
authors: ZA
authors: Nemkova
authors: M Iu
authors: MIu
authors: Kaminskiĭ
authors: R V
authors: RV
authors: Popov
authors: S L
authors: SL
authors: Trofimovich
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001930:Brain Injuries / Q000628:therapy*; D003422:Critical Care / Q000379:methods*; D004338:Drug Combinations; D005260:Female; D005486:Flavin Mononucleotide / Q000008:administration & dosage*; D006801:Humans; D007290:Inosine Diphosphate / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D009536:Niacinamide / Q000008:administration & dosage*; D011446:Prospective Studies; D013386:Succinates / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D004338:Drug Combinations; D018696:Neuroprotective Agents; D013386:Succinates; C507879:cytoflavin; D009536:Niacinamide; D005486:Flavin Mononucleotide; D007290:Inosine Diphosphate