title: Identification of the mitochondrial MSRB2 as a binding partner of LG72.
abstract: Genetic studies have linked the evolutionary novel, anthropoid primate-specific gene locus G72/G30 in the etiology of schizophrenia and other psychiatric disorders. However, the function of the protein encoded by this locus, LG72, is currently controversially discussed. Some studies have suggested that LG72 binds to and regulates the activity of the peroxisomal enzyme D-amino-acid-oxidase, while others proposed an alternative role of this protein due to its mitochondrial location in vitro. Studies with transgenic mice expressing LG72 further suggested that high levels of LG72 lead to an impairment of mitochondrial functions with a concomitant increase in reactive oxygen species production. In the present study, we now performed extensive interaction analyses and identified the mitochondrial methionine-R-sulfoxide reductase B2 (MSRB2) as a specific interaction partner of LG72. MSRB2 belongs to the MSR protein family and functions in mitochondrial oxidative stress defense. Based on our results, we propose that LG72 is involved in the regulation of mitochondrial oxidative stress.
authors: Institute of Molecular Psychiatry, University of Bonn, Bonn, Germany, d.otte@uni-bonn.de.
authors: David-Marian
authors: DM
authors: Otte
authors: Tamás
authors: T
authors: Raskó
authors: Mengzhe
authors: M
authors: Wang
authors: Michael
authors: M
authors: Dreiseidler
authors: Eva
authors: E
authors: Drews
authors: Hanna
authors: H
authors: Schrage
authors: Alexandra
authors: A
authors: Wojtalla
authors: Jörg
authors: J
authors: Höhfeld
authors: Erich
authors: E
authors: Wanker
authors: Andreas
authors: A
authors: Zimmer
mesh_terms: D000818:Animals; D019556:COS Cells; D002352:Carrier Proteins / Q000378:metabolism*; D002522:Chlorocebus aethiops; D057809:HEK293 Cells; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D051150:Methionine Sulfoxide Reductases / Q000378:metabolism*; D051379:Mice; D008840:Microfilament Proteins; D008928:Mitochondria / Q000378:metabolism*; D011485:Protein Binding; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D002352:Carrier Proteins; C475071:DAOA protein, human; D047908:Intracellular Signaling Peptides and Proteins; D008840:Microfilament Proteins; D014157:Transcription Factors; C120376:MSRB2 protein, human; D051150:Methionine Sulfoxide Reductases