title: Associations between human papillomavirus and history of cancer among U.S. adults in the National Health and Nutrition Examination Survey (2003-2010).
abstract: BACKGROUND
  Human papillomavirus (HPV) is an infectious agent that has been associated with human cancer. We have updated the U.S. population sero-prevalence using a large National Health and Nutrition Examination Survey (NHANES) sample of adults from 2003 to 2010, and have analysed the associations between HPV seropositivity and self-reported history of cancer.
  
  
  METHODS
  Four cross-sectional cycles (2003-2004, 2005-2006, 2007-2008, and 2009-2010) were used, for a total of 12 759 participants who had both cancer history and HPV serum information.
  
  
  RESULTS
  The sero-prevalences of HPV types 6, 11, 16, and 18 were 15.0%, 4.8%, 11.5%, and 4.1%, respectively. Females had significantly higher HPV prevalence than males (P<0.05) for all subtypes. Positive associations between HPV 16/18 seropositivity and lifetime history of any cancer (adjusted odds ratio-ORadj=1.68; 95% CI: 1.35, 2.01), history of any of eight selected cancers (ORadj=2.63; 95% CI: 1.78, 3.90), lung cancer (ORadj=5.14; 95% CI: 1.29, 20.44), and cervical cancer (ORadj=2.55; 95% CI: 1.63, 3.98) were observed.
  
  
  CONCLUSIONS
  The finding of significant associations between HPV 16/18 seropositivity and lifetime history of cancer adds epidemiological evidence to the carcinogenicity potential of HPV 16 and 18 in other tissues. With increasing coverage of the HPV vaccine in the U.S., future NHANES data and sample collection may allow further detailed evaluation of the population impact of the HPV vaccination on cancer prevention.
authors: Department of Population Health and the Feinstein Institute, Hofstra North Shore-LIJ School of Medicine, 175 Community Drive, Rm 203, Great Neck, NY 11021, USA.
authors: B
authors: B
authors: Liu
authors: Department of Population Health and the Feinstein Institute, Hofstra North Shore-LIJ School of Medicine, 175 Community Drive, Rm 203, Great Neck, NY 11021, USA.
authors: E
authors: E
authors: Taioli
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D052162:Human papillomavirus 16 / Q000276:immunology*; D052161:Human papillomavirus 18 / Q000276:immunology*; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D008297:Male; D008875:Middle Aged; D009749:Nutrition Surveys; D030361:Papillomavirus Infections / Q000150:complications / Q000453:epidemiology* / Q000276:immunology; D015995:Prevalence; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D014481:United States; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral