title: Vaccination against tuberculosis in badgers and cattle: an overview of the challenges, developments and current research priorities in Great Britain.
abstract: Bovine tuberculosis (TB) is a significant threat to the cattle industry in England and Wales. It is widely acknowledged that a combination of measures targeting both cattle and wildlife will be required to eradicate bovine TB or reduce its prevalence until European official freedom status is achieved. Vaccination of cattle and/or badgers could contribute to bovine TB control in Great Britain, although there are significant gaps in our knowledge regarding the impact that vaccination would actually have on bovine TB incidence. Laboratory studies have demonstrated that vaccination with BCG can reduce the progression and severity of TB in both badgers and cattle. This is encouraging in terms of the prospect of a sustained vaccination programme achieving reductions in disease prevalence; however, developing vaccines for tackling the problem of bovine TB is challenging, time-consuming and resource-intensive, as this review article sets out to explain.
authors: School of Veterinary Medicine, University of Surrey, Surrey GU2 7XH, UK and AHVLA, Addlestone, Surrey KT15 3NB, UK.
authors: M A
authors: MA
authors: Chambers
authors: AHVLA, Woodchester Park, Tinkley Lane, Stonehouse, Gloucestershire GL10 3UJ.
authors: S P
authors: SP
authors: Carter
authors: AHVLA, Woodchester Park, Tinkley Lane, Stonehouse, Gloucestershire GL10 3UJ.
authors: G J
authors: GJ
authors: Wilson
authors: AHVLA, Addlestone, Surrey KT15 3NB, UK.
authors: G
authors: G
authors: Jones
authors: Veterinary and Science Policy Advice, AHVLA, c/o Defra, 17 Smith Square, Nobel House, London SW1P 3JR, UK.
authors: E
authors: E
authors: Brown
authors: AHVLA, Addlestone, Surrey KT15 3NB, UK.
authors: R G
authors: RG
authors: Hewinson
authors: AHVLA, Addlestone, Surrey KT15 3NB, UK.
authors: M
authors: M
authors: Vordermeier
mesh_terms: D000818:Animals; D001500:BCG Vaccine / Q000008:administration & dosage*; D002417:Cattle; D045969:Mustelidae; D012106:Research; D014376:Tuberculosis / Q000517:prevention & control / Q000662:veterinary*; D014380:Tuberculosis, Bovine / Q000517:prevention & control*; D006113:United Kingdom; D014611:Vaccination / Q000662:veterinary*
chemical_list: D001500:BCG Vaccine