title: Fungal polyketide biosynthesis - a personal perspective.
abstract: This Viewpoint article provides a personal viewpoint of research in the area of fungal polyketide biosynthesis. It spans the period from the first applications and subsequent development of modern stable-isotope labelling methods, the isolation, sequencing and expression of PKS genes, biochemical and structural characterisation of PKS domains, fungal genome sequencing, through to genetic engineering of whole pathways. This article forms part of a "trilogy" of related Viewpoints from three close contemporaries who have been privileged to share in these developments since their outset over forty years ago and to enjoy both professional and personal interactions throughout that time.
authors: School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK. tom.simpson@bristol.ac.uk.
authors: Thomas J
authors: TJ
authors: Simpson
mesh_terms: D000595:Amino Acid Sequence; D005658:Fungi / Q000378:metabolism; D005818:Genetic Engineering; D016681:Genome, Fungal; D015394:Molecular Structure; D009097:Multienzyme Complexes / Q000378:metabolism; D010453:Peptide Synthases / Q000378:metabolism; D048630:Polyketide Synthases / Q000235:genetics / Q000378:metabolism*; D061065:Polyketides / Q000378:metabolism*
chemical_list: D009097:Multienzyme Complexes; D061065:Polyketides; D048630:Polyketide Synthases; D010453:Peptide Synthases