title: MRI-compatible Nb-60Ta-2Zr alloy used for vascular stents: haemocompatibility and its correlation with protein adsorption.
abstract: Nb-60Ta-2Zr is a newly developed MRI-compatible alloy used for vascular stents. In this work, its haemocompatibility was investigated, including platelet adhesion (lactate dehydrogenase activity), platelet activation (P-selectin expression), coagulation and haemolysis. For comparison, parallel assessments for these factors were performed for the niobium, tantalum, 316L stainless steel (316L SS) and L605 Co-Cr alloy (L605). In addition, albumin and fibrinogen were selected to examine the correlation of protein adsorption with platelet adhesion and metal surface properties. The propensity for platelet adhesion and activation on the Nb-60Ta-2Zr alloy was at nearly the same level as that for Nb and Ta but was slightly less than those of 316L SS and L605. The mitigated platelet adhesion and activation of the Nb-60Ta-2Zr alloy is associated with its decreased adsorption of fibrinogen. The Nb-60Ta-2Zr alloy has a longer clotting time and exhibits significantly superior thromboresistance than 316L SS and L605. Moreover, the haemolysis rate of the Nb-60Ta-2Zr alloy satisfies the bio-safety requirement of the ISO 10993-4 standard. The favourable haemocompatiblity of the Nb-60Ta-2Zr alloy provides evidence of its good biocompatibility and of its suitability as a candidate stent material.
authors: School of Stomatology, China Medical University, 117 Nanjing North Street, Shenyang 110002, China.
authors: Xiu-Mei
authors: XM
authors: Li
authors: Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, 72 Wenhua Road, Shenyang 110016, China.
authors: Hui-Zhe
authors: HZ
authors: Li
authors: Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, 72 Wenhua Road, Shenyang 110016, China.
authors: Shao-Ping
authors: SP
authors: Wang
authors: Biomaterials & Electrochemistry Lab, Department of Dentistry, National Yang-Ming University, Taipei City 112, Taiwan.
authors: Hsun-Miao
authors: HM
authors: Huang
authors: Biomaterials & Electrochemistry Lab, Department of Dentistry, National Yang-Ming University, Taipei City 112, Taiwan.
authors: Her-Hsiung
authors: HH
authors: Huang
authors: School of Stomatology, China Medical University, 117 Nanjing North Street, Shenyang 110002, China. Electronic address: aih0620@yahoo.com.cn.
authors: Hong-Jun
authors: HJ
authors: Ai
authors: Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, 72 Wenhua Road, Shenyang 110016, China. Electronic address: jianxu@imr.ac.cn.
authors: Jian
authors: J
authors: Xu
mesh_terms: D000327:Adsorption; D000497:Alloys / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D001807:Blood Vessel Prosthesis; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008422:Materials Testing; D009556:Niobium / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D015539:Platelet Activation / Q000187:drug effects; D010973:Platelet Adhesiveness / Q000187:drug effects; D015607:Stents; D015040:Zirconium / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D009556:Niobium; D015040:Zirconium
keywords: Haemocompatibility; Niobium; Platelet adhesion; Protein adsorption; Stent