title: Effects of oral moisturising gel containing egg yolk antibodies against Candida albicans in older people.
abstract: OBJECTIVE
  The aim of this study was to evaluate the inhibitory effects of oral moisturising gel containing egg yolk antibody against Candida albicans (anti-CA IgY) in older people. Therefore, we measured the number of Candia CFU present on oral swabs at baseline and after using the gel.
  
  
  METHODS
  A randomised, double-blind, placebo-controlled trial was conducted among volunteers living in a nursing home in Japan. The participants were divided into two groups. The group 1 participants received oral care using an experimental oral moisturising gel with anti-CA IgY, and those in group 2 received oral care using a placebo oral moisturising gel without anti-CA IgY. The oral care was performed by care workers three times a day for 4 weeks. The participants' tongues were sampled using a swab method at baseline and after 2 and 4 weeks of using the oral gel, and the number of C. albicans, Candida tropicalis and Candida krusei colonies was counted.
  
  
  RESULTS
  The baseline oral condition of the participants in the two groups did not differ significantly. The experimental gel significantly reduced the number of C. albicans colonies from baseline to after 4 weeks of using the oral gel; however, no significant reductions were observed in the number of C. tropicalis or C. krusei colonies.
  
  
  CONCLUSIONS
  The use of oral moisturising gel containing anti-CA IgY for 1 month significantly reduces the number of C. albicans CFU present on swabs in older people.
authors: Department of Community Dentistry, Tsurumi University School of Dental Medicine, Yokohama, Japan.
authors: Susumu
authors: S
authors: Takeuchi
authors: Department of Community Dentistry, Tsurumi University School of Dental Medicine, Yokohama, Japan.
authors: Jun
authors: J
authors: Motohashi
authors: Department of Geriatric Dentistry, Tsurumi University School of Dental Medicine, Yokohama, Japan.
authors: Hisato
authors: H
authors: Kimori
authors: Department of Clinical Pathophysiology, Tsurumi University Dental Hospital, Yokohama, Japan.
authors: Yoichi
authors: Y
authors: Nakagawa
authors: Department of Community Dentistry, Tsurumi University School of Dental Medicine, Yokohama, Japan.
authors: Akihisa
authors: A
authors: Tsurumoto
mesh_terms: D000369:Aged, 80 and over; D000908:Antibodies, Fungal / Q000276:immunology / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects / Q000254:growth & development / Q000276:immunology; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development / Q000276:immunology; D041022:Candida tropicalis / Q000187:drug effects / Q000254:growth & development / Q000276:immunology; D002180:Candidiasis, Oral / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology; D015169:Colony Count, Microbial; D004311:Double-Blind Method; D004530:Egg Yolk / Q000276:immunology*; D005260:Female; D006801:Humans; D007136:Immunoglobulins; D007564:Japan; D008297:Male; D009735:Nursing Homes; D009910:Oral Hygiene; D014059:Tongue / Q000187:drug effects / Q000382:microbiology; D014838:Volunteers
chemical_list: D000908:Antibodies, Fungal; C016512:IgY; D007136:Immunoglobulins
keywords: Candida; candidiasis; egg yolk antibody; oral moisturising gel; randomized controlled trial.