title: Relationship between asymmetric dimethylarginine and nocturia in the general elderly population: The HEIJO-KYO cohort.
abstract: OBJECTIVE
  To evaluate the relationship between asymmetric dimethylarginine (ADMA) and nocturia.
  
  
  METHODS
  A total of 862 community-based elderly individuals were examined in this cross-sectional study (mean age, 72.1 years). We measured nocturnal void frequency and serum ADMA levels. Nocturia was ascertained for a frequency of two or more nocturnal voids.
  
  
  RESULTS
  Nocturia was observed in 262 (30.4%) participants. Univariate logistic regression models revealed a significant association between prevalent nocturia and ADMA levels (crude odds ratio [OR], 1.556 [2nd vs. 1st tertile]; 95% confidence interval [CI], 1.066-2.270; P = 0.022; crude OR, 2.114 [3rd vs. 1st tertile]; 95% CI, 1.453-3.072; P < 0.001). Univariate logistic regression models also revealed marginal to significant associations between prevalent nocturia and age, gender, calcium channel blocker use, nitric oxide-related drug use, diabetes, estimated glomerular filtration rate, insomnia, benign prostatic hyperplasia, overnight urine volume, and endogenous melatonin levels. In the multivariate model simultaneously adjusted for the former variables, higher ADMA levels were significantly associated with higher OR for nocturia (adjusted OR, 1.556 [3rd vs. 1st tertiles]; 95% CI, 1.010-2.397; P = 0.045).
  
  
  CONCLUSIONS
  Serum ADMA levels, an endogenous inhibitor of nitric oxide synthase, are significantly associated with prevalent nocturia in the general elderly population.
authors: Department of Community Health and Epidemiology, Nara Medical University School of Medicine, Nara, Japan.
authors: Kenji
authors: K
authors: Obayashi
authors: Department of Community Health and Epidemiology, Nara Medical University School of Medicine, Nara, Japan.
authors: Keigo
authors: K
authors: Saeki
authors: Department of Community Health and Epidemiology, Nara Medical University School of Medicine, Nara, Japan.
authors: Norio
authors: N
authors: Kurumatani
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D053158:Nocturia / Q000097:blood* / Q000453:epidemiology; D015995:Prevalence
chemical_list: C018524:N,N-dimethylarginine; D001120:Arginine
keywords: asymmetric dimethylarginine; bladder capacity; bladder dysfunction; nitric oxide; nocturia