title: Population pharmacokinetics of abacavir in pregnant women.
abstract: For the first time, a population approach was used to describe abacavir (ABC) pharmacokinetics in HIV-infected pregnant and nonpregnant women. A total of 266 samples from 150 women were obtained. No covariate effect (from age, body weight, pregnancy, or gestational age) on ABC pharmacokinetics was found. Thus, it seems unnecessary to adapt the ABC dosing regimen during pregnancy.
authors: EA 08 Université Paris Descartes, Sorbonne Paris Cité, Paris, France Unité de Recherche Clinique, AP-HP, Hôpital Tarnier, Paris, France florisfauchet@gmail.com.
authors: Floris
authors: F
authors: Fauchet
authors: EA 08 Université Paris Descartes, Sorbonne Paris Cité, Paris, France Unité de Recherche Clinique, AP-HP, Hôpital Tarnier, Paris, France Service de Pharmacologie Clinique, AP-HP, Groupe Hospitalier Paris Centre, Paris, France CIC-0901 Inserm, Cochin-Necker, Paris, France.
authors: Jean-Marc
authors: JM
authors: Treluyer
authors: EA 08 Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors: Laure-Helene
authors: LH
authors: Préta
authors: EA 08 Université Paris Descartes, Sorbonne Paris Cité, Paris, France Unité de Recherche Clinique, AP-HP, Hôpital Tarnier, Paris, France.
authors: Elodie
authors: E
authors: Valade
authors: Service de Gynécologie-Obstétrique, Maternité Port Royal, Groupe Hospitalier Paris Centre, Paris, France.
authors: Emmanuelle
authors: E
authors: Pannier
authors: EA 08 Université Paris Descartes, Sorbonne Paris Cité, Paris, France Unité de Recherche Clinique, AP-HP, Hôpital Tarnier, Paris, France CIC-0901 Inserm, Cochin-Necker, Paris, France.
authors: Saik
authors: S
authors: Urien
authors: EA 08 Université Paris Descartes, Sorbonne Paris Cité, Paris, France Unité de Recherche Clinique, AP-HP, Hôpital Tarnier, Paris, France Service de Pharmacologie Clinique, AP-HP, Groupe Hospitalier Paris Centre, Paris, France CIC-0901 Inserm, Cochin-Necker, Paris, France.
authors: Déborah
authors: D
authors: Hirt
mesh_terms: D019380:Anti-HIV Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D015224:Dideoxynucleosides / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005260:Female; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D011247:Pregnancy; D000099227:Abacavir
chemical_list: D019380:Anti-HIV Agents; D015224:Dideoxynucleosides; D000099227:Abacavir