title: Finding sessile serrated adenomas: is it possible to identify them during conventional colonoscopy?
abstract: OBJECTIVE
  Proximal colorectal cancer may arise from sessile serrated adenomas (SSAs). Recognition of these lesions during colonoscopy can optimize the endoscopic approach. We aimed to identify specific endoscopic features of SSA with conventional colonoscopy.
  
  
  METHODS
  Patients undergoing screening colonoscopies from January 2011 to September 2012, in whom colonic polyps were found, were prospectively included in our study. Polyp morphology, location, polyp pit pattern (Kudo classification), and other previously reported features of SSA were evaluated. Histological examination was conducted independently by two pathologists. Multivariate analysis was performed to identify independent predictors of SSA.
  
  
  RESULTS
  A total of 272 patients were included, and 440 polyps were evaluated (1.6 polyps per patient). Thirty-four polyps (8%) were SSA, 135 (31%) hyperplastic, and 249 (56%) adenomas. The most prevalent endoscopic features of SSA were right-side location (94%), type II Kudo pit pattern (91%), mucus cap (41%), flat morphology (29%) and red-colored surface (26%). Multivariate analysis revealed that flat morphology (p = 0.002, OR = 3.81 CI 1.53-9.09), red-colored surface (p < 0.001, OR = 12.97 CI 4.43-37.69), right-side location (p < 0.001, OR = 22.21 CI 5.09-135.94) and mucus cap (p < 0.001, OR 8.77 CI 3.76-20.44) were independent predictors of SSA.
  
  
  CONCLUSIONS
  We were able to identify specific features of SSA during conventional colonoscopy, which may help to identify, and therefore to optimize the endoscopic approach of these lesions.
authors: Division of Gastroenterology and Endoscopy, Department of Medicine, Hospita Alemán, Pueyrredón 1640, Buenos Aires, Argentina, Lisandro_pereyra@hotmail.com.
authors: Lisandro
authors: L
authors: Pereyra
authors: Estanislao J
authors: EJ
authors: Gómez
authors: Raquel
authors: R
authors: González
authors: Carolina
authors: C
authors: Fischer
authors: Gastón Babot
authors: GB
authors: Eraña
authors: Alfredo G
authors: AG
authors: Torres
authors: Leandro
authors: L
authors: Correa
authors: José M
authors: JM
authors: Mella
authors: Guillermo N
authors: GN
authors: Panigadi
authors: Pablo
authors: P
authors: Luna
authors: Silvia C
authors: SC
authors: Pedreira
authors: Daniel G
authors: DG
authors: Cimmino
authors: Luis A
authors: LA
authors: Boerr
mesh_terms: D000236:Adenoma / Q000145:classification* / Q000175:diagnosis / Q000473:pathology*; D003110:Colonic Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D003113:Colonoscopy / Q000592:standards*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis