title: Delivery of Amphotericin B for Effective Treatment of Candida Albicans Induced Dermal Mycosis in Rats via Emulgel System: Formulation and Evaluation.
abstract: BACKGROUND
  Amphotericin B (AmB) is among the gold standard antifungal agents used for the treatment of the wide range of fungal infections. However, the drug has various side- effects. Transdermal approach for the delivery of drug is one of the accepted and convenient modes of drug delivery.
  
  
  OBJECTIVE
  The current work was designed to formulate and to evaluate the AmB emulgel system.
  
  
  METHODS
  In the preparation of AmB emulgel, Carbopol 930 was used as a gel in this study. The formulation was evaluated for viscosity, spreadability, drug content, drug release and in vitro and in vivo antifungal testing.
  
  
  RESULTS
  AmB emulgel was found to penetrate skin effectively and without any irritation. Further, in vivo studies revealed effective therapeutic potential against Candida albicans induced dermal mycosis.
  
  
  CONCLUSIONS
  The current work, for the first time, revealed effective delivery of AmB across the skin.
authors: Drug Discovery Laboratory, Shri Ram Institute of Technology-Pharmacy, Jabalpur, Madhya Pradesh, India.
authors: Aditya
authors: A
authors: Ganeshpurkar
authors: Drug Discovery Laboratory, Shri Ram Institute of Technology-Pharmacy, Jabalpur, Madhya Pradesh, India.
authors: Pooja
authors: P
authors: Vaishya
authors: Drug Discovery Laboratory, Shri Ram Institute of Technology-Pharmacy, Jabalpur, Madhya Pradesh, India.
authors: Sumeet
authors: S
authors: Jain
authors: Pharmaceutics Research Laboratory, Shri Ram Institute of Technology-Pharmacy, Jabalpur, Madhya Pradesh, India.
authors: Vikas
authors: V
authors: Pandey
authors: Pharmaceutics Research Laboratory, Shri Ram Institute of Technology-Pharmacy, Jabalpur, Madhya Pradesh, India.
authors: Divya
authors: D
authors: Bansal
authors: Drug Discovery Laboratory, Shri Ram Institute of Technology-Pharmacy, Jabalpur, Madhya Pradesh, India.
authors: Nazneen
authors: N
authors: Dubey
keywords: Amphotericin B; carbopol; emulgel; permeation; transdermal