title: Activity of cytokine-induced killer cells against bone and soft tissue sarcoma.
abstract: Cytokine-induced killer (CIK) cells are T lymphocytes expanded ex vivo that are endowed with MHC-independent tumoricidal activity. We have recently demonstrated, in a preclinical setting, that CIK cells are active against autologous bone and soft tissue sarcomas. In particular, CIK cells killed a putative sarcoma stem cell population that may underlie disease relapse and chemoresistance.
authors: Department of Oncology; University of Torino; Torino, Italy ; Laboratory of Medical Oncology; Experimental Cell Therapy Unit; Candiolo Cancer Institute; Candiolo, Turin, Italy.
authors: Dario
authors: D
authors: Sangiolo
authors: Department of Oncology; University of Torino; Torino, Italy ; Laboratory of Medical Oncology; Candiolo Cancer Institute-FPO; IRCCS Candiolo; Candiolo, Turin, Italy.
authors: Giulia
authors: G
authors: Mesiano
authors: Laboratory of Medical Oncology; Candiolo Cancer Institute-FPO; IRCCS Candiolo; Candiolo, Turin, Italy.
authors: Loretta
authors: L
authors: Gammaitoni
authors: Department of Oncology; University of Torino; Torino, Italy ; Division and Laboratory of Medical Oncology; Candiolo Cancer Institute-FPO; IRCCS Candiolo; Candiolo, Turin, Italy.
authors: Massimo
authors: M
authors: Aglietta
authors: Division and Laboratory of Medical Oncology; Candiolo Cancer Institute-FPO; IRCCS Candiolo; Candiolo, Turin, Italy.
authors: Giovanni
authors: G
authors: Grignani
keywords: CIK cells; adoptive immunotherapy; cancer stem cells; sarcomas; solid tumors