title: Catalytic enantioselective C-H functionalization of alcohols by redox-triggered carbonyl addition: borrowing hydrogen, returning carbon.
abstract: The use of alcohols and unsaturated reactants for the redox-triggered generation of nucleophile-electrophile pairs represents a broad, new approach to carbonyl addition chemistry. Discrete redox manipulations that are often required for the generation of carbonyl electrophiles and premetalated carbon-centered nucleophiles are thus avoided. Based on this concept, a broad, new family of enantioselective C-C coupling reactions that are catalyzed by iridium or ruthenium complexes have been developed, which are summarized in this Minireview.
authors: University of Texas at Austin, Department of Chemistry and Biochemistry, 1 University Station - A5300, Austin, TX 78712-1167 (USA).
authors: John M
authors: JM
authors: Ketcham
authors: Inji
authors: I
authors: Shin
authors: T Patrick
authors: TP
authors: Montgomery
authors: Michael J
authors: MJ
authors: Krische
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D002244:Carbon; D006859:Hydrogen
keywords: enantioselective catalysis; iridium; polyketide natural products; ruthenium; transfer hydrogenation