title: Retapamulin 1% Ointment and Clobetasol Propionate 0.05% Foam is More Efficacious than Vehicle Ointment and Clobetasol 0.05% Propionate Foam in the Treatment of Hand/Foot Dermatitis: A Single Center, Randomized, Double-blind Study.
abstract: BACKGROUND
  Staphylococcus aureus has been implicated in the pathogenesis of adult hand/foot dermatitis.
  
  
  OBJECTIVE
  The authors hypothesized that retapamulin 1% ointment and clobetasol propionate 0.05% foam would decrease disease severity in subjects with hand/foot dermatitis and provide a higher clearance of Staphylococcus aureus colonization, when compared to vehicle (placebo) ointment and clobetasol propionate 0.05% foam.
  
  
  METHODS
  Adult subjects with moderate to very severe hand/foot dermatitis had twice-daily topical application of clobetasol propionate 0.05% foam to hands/feet for 14 days and were randomized to apply either retapamulin 1% ointment or vehicle ointment twice daily to hands/feet and nares for five days.
  
  
  RESULTS
  Seventy-three percent of subjects in the retapamulin/clobetasol group were clear/almost clear at Day 15 compared to 47 percent of subjects in the vehicle/clobetasol group (p-value of 0.04). The percentage of subjects who had both negative skin and nares cultures and were clear/almost clear was also statistically significant in favor of the retapamulin/clobetasol group at Day 15 (p-value of 0.05).
  
  
  CONCLUSIONS
  Sample size, study population.
  
  
  CONCLUSIONS
  At Day 15, retapamulin 1% ointment with clobetasol propionate 0.05% foam was more efficacious than vehicle ointment and clobetasol propionate 0.05% foam for disease improvement and Staphylococcus aureus clearance in adult subjects with hand/foot dermatitis.
authors: Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York.
authors: Madelaine
authors: M
authors: Haddican
authors: Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York.
authors: Rita V
authors: RV
authors: Linkner
authors: Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York.
authors: Giselle
authors: G
authors: Singer
authors: Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York.
authors: Shelbi C
authors: SC
authors: Jim
authors: Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York.
authors: Matthew
authors: M
authors: Gagliotti
authors: Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York.
authors: Gary
authors: G
authors: Goldenberg