title: [Glucose-6-phosphate dehydrogenase deficiency in children: a case report].
abstract: BACKGROUND
  Glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency) is the most common red blood cell (RBC) enzyme disorder. The decrease as well as the absence of the enzyme increase RBC vulnerability to oxidative stress caused by exposure to certain medications or intake of fava beans. Among the most common clinical manifestations of this condition, acute hemolysis, chronic hemolysis, neonatal hyperbilirubinemia, and an asymptomatic form are observed.
  
  
  OBJECTIVE
  To analyze the case of a child who presented hemolytic crisis due to favism.
  
  
  METHODS
  A 2 year and 7 month old boy with a history of hyperbilirubinemia during the newborn period with no apparent cause, no family history of hemolytic anemia or parental consanguinity. He presented a prolonged neonatal jaundice and severe anemia requiring RBC transfusion. An intake of fava beans 48 h prior to onset of symptoms was reported. G6PD qualitative determination was compatible with this enzyme deficiency.
  
  
  CONCLUSIONS
  G6PD deficiency can be highly variable in its clinical presentation, so it is necessary to keep it in mind during the diagnosis of hemolytic anemia at any age.
authors: Patricia
authors: P
authors: Verdugo L
authors: Marlene
authors: M
authors: Calvanese T
authors: Diego
authors: D
authors: Rodríguez V
authors: Cassandra
authors: C
authors: Cárcamo C
mesh_terms: D002675:Child, Preschool; D005236:Favism / Q000175:diagnosis*; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D051556:Hyperbilirubinemia, Neonatal / Q000473:pathology; D008297:Male; D031307:Vicia faba / Q000009:adverse effects*