title: Serum levels of the soluble IL-1 receptor family member ST2 and right ventricular dysfunction.
abstract: OBJECTIVE
  We aimed to assess the relationship between right ventricle (RV) dysfunction parameters and the soluble IL-1 receptor family member (sST2) in patients with secondary pulmonary hypertension owing tochronic obstructive pulmonary disease.
  
  
  METHODS
  A total of 36 patients with chronic obstructive pulmonary disease and secondary pulmonary hypertension (mean age: 59 ± 7 years) and 36 healthy volunteers (mean age: 59 ± 8 years) were enrolled in the study. sST2 and NT-proBNP levels, as well as specific echocardiographic parameters were measured.
  
  
  RESULTS
  Both sST2 and NT-proBNP levels were greater in the test group. The sST2 levels were inversely associated with RV fractional area change(r = -0.762; p < 0.001), as well as with the RV ejection fraction (r = -0.799; p < 0.001), tricuspid annular plane systolic excursion (r = -0.773; p < 0.001) and increased pulmonary artery systolic pressure (r = 0.603;p < 0.001). Receiver operating characteristic curve analysis revealed that sST2 had lower sensitivity for identifying RV dysfunction when compared with NT-proBNP (71.4 vs 100%), despite having the same specificity (84%).
  
  
  CONCLUSIONS
  The current study reveals correlations between sST2 levels and echocardiographic parameters of RV dysfunction, suggesting that use of sST2 and NT-proBNP may improve diagnosis and risk stratification in patients with secondary pulmonary hypertension owing to chronic obstructive pulmonary disease.
authors: Department of Medical Sciences, Iuliu Hatieganu University of Medicine & Pharmacy, 2–4 Clinicilor, 400006, Cluj-Napoca, Romania
authors: Lucia
authors: L
authors: Agoston-Coldea
authors: Silvia
authors: S
authors: Lupu
authors: Sergiu
authors: S
authors: Hicea
authors: Armony
authors: A
authors: Paradis
authors: Teodora
authors: T
authors: Mocan
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology; D000072179:Interleukin-1 Receptor-Like 1 Protein; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications; D011956:Receptors, Cell Surface / Q000097:blood*; D018497:Ventricular Dysfunction, Right / Q000097:blood* / Q000209:etiology
chemical_list: D015415:Biomarkers; C079241:IL1RL1 protein, human; D000072179:Interleukin-1 Receptor-Like 1 Protein; D010446:Peptide Fragments; D011956:Receptors, Cell Surface; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain