title: Effect of resveratrol on exercise capacity: a randomized placebo-controlled crossover pilot study.
abstract: To assess the effect on exercise capacity and tolerability of resveratrol, 13 healthy, sedentary adult volunteers were enrolled in a randomized crossover study comparing resveratrol and placebo over two 4-week periods, with a 2-week time between periods when subjects received no treatment. No significant changes in exercise duration or aerobic capacity (peak oxygen uptake) were observed. Gastrointestinal side effects were more common during resveratrol treatment (77% vs. 15%, p = 0.0048). A small reduction in fasting glucose and small but statistically significant increases in liver enzymes, total cholesterol, and triglycerides were observed, although mean results remained within normal limits. There was no change in complete blood count, inflammatory markers, renal function, or other measures of liver function.
authors: a Department of Medicine, Division of Respirology, University of Ottawa at The Ottawa Hospital, General Campus, 501 Smyth Road, Box 211, Ottawa, ON K1H 8L6, Canada.
authors: Nha
authors: N
authors: Voduc
authors: Charles
authors: C
authors: la Porte
authors: Caroline
authors: C
authors: Tessier
authors: Ranjeeta
authors: R
authors: Mallick
authors: D William
authors: DW
authors: Cameron
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018592:Cross-Over Studies; D004311:Double-Blind Method; D015444:Exercise / Q000502:physiology*; D017079:Exercise Tolerance / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D055815:Young Adult
chemical_list: D013267:Stilbenes; D000077185:Resveratrol
keywords: capacité physique; exercise capacity; resveratrol; resvératrol; safety; sécurité; tolerability; tolérabilité