title: Interactions Between Early Trauma and Catechol-O-Methyltransferase Genes on Inhibitory Deficits in Children With ADHD.
abstract: To investigate the interaction between childhood trauma exposure with the catechol-O-methyltransferase (COMT) and dopamine receptor D4 (DRD4) polymorphisms in relation to neuropsychological measures in children with ADHD.
  
  
  
  A cross-sectional examination of early traumatic experiences and the continuous performance test (CPT) were performed in 55 children with ADHD. Participants were also genotyped for the DRD4 exon III 48-bp variable number of tandem repeats (VNTR) polymorphism and the COMT Val158-Met (rs4680) polymorphism.
  
  
  
  There was significant interaction between the effects of the COMT genotype and trauma in commission errors. In participants with ADHD carrying the COMT Val/Val genotype, the group exposed to trauma showed significantly higher commission errors than the non-traumatized group. However, for the participants with other genotypes, no significant differences were found.
  
  
  
  This study suggests that there exists a genetic influence on the association between childhood trauma and the severity of inhibitory deficits in children with ADHD.
authors: 1 Seoul National Hospital, Repulic of Korea.
authors: Subin
authors: S
authors: Park
authors: 2 Seoul National University, Republic of Korea.
authors: Bung-Nyun
authors: BN
authors: Kim
authors: 2 Seoul National University, Republic of Korea.
authors: Jae-Won
authors: JW
authors: Kim
authors: 2 Seoul National University, Republic of Korea.
authors: Min-Sup
authors: MS
authors: Shin
authors: 2 Seoul National University, Republic of Korea.
authors: Hee Jeong
authors: HJ
authors: Yoo
authors: 2 Seoul National University, Republic of Korea.
authors: Soo-Churl
authors: SC
authors: Cho
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000201:enzymology / Q000235:genetics*; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D002648:Child; D003430:Cross-Sectional Studies; D005091:Exons / Q000235:genetics; D005260:Female; D059647:Gene-Environment Interaction; D005838:Genotype; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D018598:Minisatellite Repeats / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D050638:Receptors, Dopamine D4 / Q000235:genetics*; D040921:Stress Disorders, Traumatic / Q000201:enzymology / Q000235:genetics*
chemical_list: C493599:DRD4 protein, human; D050638:Receptors, Dopamine D4; D002394:Catechol O-Methyltransferase
keywords: ADD/ADHD; neuropsychological functioning; trauma