title: Medicinal applications of perfluoroalkylated chain-containing compounds.
abstract: Compounds with polyfluorinated molecular fragments possess unique properties associated with the presence of a large number of fluorine atoms that affect lipophilicity and conformational rigidity of the parent molecule along with other effects. The aim of this review is to provide an overview of synthesized compounds possessing perfluoroalkylated or polyfluorinated chains that have been tested for bioactivity or as potential drug candidates for the treatment of various diseases. As far as the length of the perfluoroalkylated chain is concerned the focus is centered on the compound bearing perfluoroethyl or tetrafluoroethyl as well as longer chains. The perfluoroalkylated compounds discussed are classified according to their biological activity.
authors: Department of Organic Chemistry, Faculty of Science, Charles University in Prague, Hlavova 8, 128 43 Praha 2, Czech Republic.
authors: Eva
authors: E
authors: Prchalová
authors: Ondřej
authors: O
authors: Štěpánek
authors: Stanislav
authors: S
authors: Smrček
authors: Martin
authors: M
authors: Kotora
mesh_terms: D000478:Alkylation; D000818:Animals; D055808:Drug Discovery / Q000379:methods; D005466:Fluorocarbons / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans
chemical_list: D005466:Fluorocarbons