title: The role of multi-purpose solutions in prevention and removal of lipid depositions on contact lenses.
abstract: The sorption and desorption of radiolabeled dipalmitoylphosphatidylcholine (DPPC) and cholesterol (CH) were measured on 5 types of commercial contact lenses. The lenses were soaked in vitro in an artificial tear fluid for 16h. The effects of borate buffered saline and two commercial multi-purpose lens-care solutions (MPSs) on reducing the lipid (DPPC and CH) sorption and increasing the lipid removal were examined. The results showed that silicone hydrogel (SiHy) lenses accumulated the most lipids, sorbing over an order of magnitude more than polymacon, a conventional hydrogel lens. Pre-soaking the SiHy lenses for 16h in MPSs reduced the DPPC sorption by up to 13% and the CH sorption by up to 11%, compared to controls that were not pre-soaked. However neither these reductions nor those on polymacon were statistically significant (p>0.05). In sorption experiments without presoaking, subsequent exposure to the MPSs removed some DPPC from the lenses (0-3.1% for SiHy lenses and 14-55% for polymacon), but CH removal was 0.0-0.8% for SiHy lenses and 0.6-28% for polymacon lenses. Some of these removals were statistically significant (p<0.05).
authors: Brigham Young University, 350 Clyde Building, Provo, UT 84602, USA.
authors: Ngai Keung
authors: NK
authors: Tam
authors: Brigham Young University, 350 Clyde Building, Provo, UT 84602, USA. Electronic address: pitt@byu.edu.
authors: William G
authors: WG
authors: Pitt
authors: Brigham Young University, 350 Clyde Building, Provo, UT 84602, USA.
authors: Krystian X
authors: KX
authors: Perez
authors: Brigham Young University, 350 Clyde Building, Provo, UT 84602, USA.
authors: Erika
authors: E
authors: Handly
authors: Brigham Young University, 350 Clyde Building, Provo, UT 84602, USA.
authors: Andrew A
authors: AA
authors: Glenn
authors: Brigham Young University, 350 Clyde Building, Provo, UT 84602, USA.
authors: John W
authors: JW
authors: Hickey
authors: Brigham Young University, 350 Clyde Building, Provo, UT 84602, USA.
authors: Brian G
authors: BG
authors: Larsen
mesh_terms: D000327:Adsorption; D001672:Biocompatible Materials / Q000032:analysis / Q000737:chemistry*; D018639:Contact Lens Solutions / Q000032:analysis / Q000737:chemistry*; D003261:Contact Lenses; D004866:Equipment Contamination / Q000517:prevention & control*; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D065346:Lubricant Eye Drops / Q000737:chemistry*; D008422:Materials Testing; D013666:Tears / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D018639:Contact Lens Solutions; D008055:Lipids; D065346:Lubricant Eye Drops
keywords: Artificial tear fluid; Lipid removal; Multi-purpose lens care solution; Phospholipid and cholesterol sorption; Radiolabeled lipids; Silicone hydrogel contact lens