title: Diazepam and fluoxetine decrease the stress response in zebrafish.
abstract: The presence of pharmaceutical products in the aquatic environment has been reported in several studies. However, the impact of these drugs on living organisms is still uncharacterized. Here, we investigated the effects of acute exposure to either diazepam or fluoxetine on the stress response in Danio rerio. We showed that diazepam and fluoxetine inhibited the stress axis in zebrafish. Intermediate concentrations of diazepam suppressed the stress response as measured by cortisol levels, whereas fluoxetine inhibited cortisol increase at concentrations similar to those found in the environment. These data suggest that the presence of psychoactive drugs in aquatic ecosystems could cause neuroendocrine dysfunction in fish.
authors: Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brasil.
authors: Murilo Sander de
authors: MS
authors: Abreu
authors: Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brasil.
authors: Gessi
authors: G
authors: Koakoski
authors: Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brasil.
authors: Daiane
authors: D
authors: Ferreira
authors: Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brasil.
authors: Thiago Acosta
authors: TA
authors: Oliveira
authors: Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brasil.
authors: João Gabriel Santos da
authors: JG
authors: Rosa
authors: Universidade de Passo Fundo (UPF), Passo Fundo, RS, Brasil.
authors: Darlan
authors: D
authors: Gusso
authors: Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brasil; Universidade de Passo Fundo (UPF), Passo Fundo, RS, Brasil.
authors: Ana Cristina Varrone
authors: AC
authors: Giacomini
authors: Departamento de Farmacologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.
authors: Angelo Luis
authors: AL
authors: Piato
authors: Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brasil; Programa de Pós-Graduação em Bioexperimentação, Universidade de Passo Fundo (UPF), Passo Fundo, RS, Brasil.
authors: Leonardo José Gil
authors: LJ
authors: Barcellos
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology*; D005260:Female; D005473:Fluoxetine / Q000494:pharmacology*; D008297:Male; D013312:Stress, Physiological / Q000187:drug effects*; D014874:Water Pollutants, Chemical / Q000494:pharmacology*; D015027:Zebrafish / Q000502:physiology*
chemical_list: D014151:Anti-Anxiety Agents; D018687:Antidepressive Agents, Second-Generation; D014874:Water Pollutants, Chemical; D005473:Fluoxetine; D003975:Diazepam