title: Effects of antenatal hypoxia on the parameters of tissue homeostasis in the liver of albino rats.
abstract: We studied age-dependent dynamics of some liver parameters in albino rats after antenatal hypoxia. A decrease in body weight, absolute liver weight in newborn and mature rats, and a reduction of relative weight of the liver in mature animals were observed under these conditions. It was found that antenatal hypoxia promotes a decrease in DNA-synthetic activity of hepatocytes, intensifies free radical processes in the liver of newborn rats, and reduces the number of nucleoli in hepatocytes. In mature animals, antenatal hypoxia was followed by a decrease in hepatocyte sizes and area of nucleoli, an increase in the number of binuclear cells relative to mononuclear cells, and a decrease in the number of nucleoli in hepatocyte nuclei. These data can reflect impairment of tissue homeostasis in the liver of mammals exposed to antenatal hypoxia.
authors: Far-Easter State Medical University, Vladivostok, Russia, pinaeva_og@mail.ru.
authors: O G
authors: OG
authors: Pinaeva
authors: O A
authors: OA
authors: Lebed'ko
authors: D V
authors: DV
authors: Yakovenko
authors: S S
authors: SS
authors: Timoshin
authors: S K
authors: SK
authors: Pinaev
authors: E N
authors: EN
authors: Sazonova
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D001835:Body Weight; D015687:Cell Hypoxia; D005260:Female; D022781:Hepatocytes / Q000502:physiology; D006706:Homeostasis; D008099:Liver / Q000473:pathology*; D009929:Organ Size; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000473:pathology*; D051381:Rats; D059807:S Phase Cell Cycle Checkpoints