title: Learning strategy preference of 5XFAD transgenic mice depends on the sequence of place/spatial and cued training in the water maze task.
abstract: Learning strategy preference was assessed in 5XFAD mice, which carry 5 familial Alzheimer's disease (AD) mutations. Mice were sequentially trained in cued and place/spatial versions of the water maze task. After training, a strategy preference test was conducted in which mice were required to choose between the spatial location where the platform had previously been during the place/spatial training, and a visible platform in a new location. 5XFAD and non-transgenic control mice showed equivalent escape performance in both training tasks. However, in the strategy preference test, 5XFAD mice preferred a cued strategy relative to control mice. When the training sequence was presented in the reverse order (i.e., place/spatial training before cued training), 5XFAD mice showed impairments in place/spatial training, but no differences in cued training or in the strategy preference test comparing to control. Analysis of regional Aβ42 deposition in brains of 5XFAD mice showed that the hippocampus, which is involved in the place/spatial learning strategy, had the highest levels of Aβ42 and the dorsal striatum, which is involved in cued learning strategy, showed a small increase in Aβ42 levels. The effect of training protocol order on performance, and regional differences in Aβ42 deposition observed in 5XFAD mice, suggest differential functional recruitment of brain structures related to learning in healthy and AD individuals.
authors: Department of Biological Sciences, Konkuk University, Seoul 143-701, Republic of Korea.
authors: Woo-Hyun
authors: WH
authors: Cho
authors: Department of Biological Sciences, Konkuk University, Seoul 143-701, Republic of Korea.
authors: Jung-Cheol
authors: JC
authors: Park
authors: Department of Biological Sciences, Konkuk University, Seoul 143-701, Republic of Korea.
authors: ChiHye
authors: C
authors: Chung
authors: Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea.
authors: Won Kyung
authors: WK
authors: Jeon
authors: Department of Biological Sciences, Konkuk University, Seoul 143-701, Republic of Korea. Electronic address: jshan06@konkuk.ac.kr.
authors: Jung-Soo
authors: JS
authors: Han
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics* / Q000523:psychology*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D000818:Animals; D001921:Brain / Q000378:metabolism; D003463:Cues; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic; D053764:Presenilin-1 / Q000235:genetics; D065854:Spatial Navigation / Q000502:physiology*
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; C508853:PSEN1 protein, human; D053764:Presenilin-1
keywords: Alzheimer's disease; Amyloid beta; Cued training; Learning strategy; Place/spatial training