title: The efficacy and tolerability of frovatriptan and dexketoprofen for the treatment of acute migraine attacks.
abstract: Frovatriptan is a triptan characterized by a high affinity for 5-HT1B/1D receptors and a long half-life contributing to a more sustained and prolonged action than other triptans. Dexketoprofen is a nonsteroidal anti-inflammatory drug with a relatively short half-life and rapid onset of action, blocking the action of cyclo-oxygenase, which is involved in prostaglandins' production, thus reducing inflammation and pain. Both drugs have been successfully employed as monotherapies for the treatment of acute migraine attacks. The combination of these two drugs (frovatriptan 2.5 mg plus dexketoprofen 25 or 37.5 mg) has been tested in migraine sufferers, showing a rapid and good initial efficacy, with 2-h pain free rates of 51%, and a high persistence in the 48-h following the onset of pain: recurrence occurred in only 29% of attacks and sustained pain free rates were 43% at 24- and 33% at 48-h.
authors: Women's Headache Center, Department of Surgical Sciences,University of Turin, Via Ventimiglia 3, 10126 Turin, Italy.
authors: Gianni
authors: G
authors: Allais
authors: Sara
authors: S
authors: Rolando
authors: Cristina
authors: C
authors: De Lorenzo
authors: Chiara
authors: C
authors: Benedetto
mesh_terms: D000208:Acute Disease; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002227:Carbazoles / Q000627:therapeutic use*; D006801:Humans; D007660:Ketoprofen / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008881:Migraine Disorders / Q000188:drug therapy*; D017366:Serotonin Receptor Agonists / Q000627:therapeutic use*; D016896:Treatment Outcome; D014325:Tromethamine / Q000627:therapeutic use*; D014363:Tryptamines / Q000627:therapeutic use*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002227:Carbazoles; D017366:Serotonin Receptor Agonists; D014363:Tryptamines; D014325:Tromethamine; D007660:Ketoprofen; C108128:frovatriptan; C118296:dexketoprofen trometamol
keywords: dexketoprofen; frovatriptan; menstrually related migraine; migraine; nonsteroidal anti-inflammatory drugs; triptans