title: The protective effect of curcumin on hepatotoxicity and ultrastructural damage induced by cisplatin.
abstract: We investigate the protective effect of curcumin (CU) on the hepatic ultrastructural damage induced by cisplatin in mice. 18 adult Kunming mice were randomly divided into normal saline (NS) group, cisplatin treatment group (CP) and CU + CP group (n = 6 for each group). Mice in control group and CP group were administered with NS (20 mL/kg/day) and CU + CP group were i.p injected with CU (200 mg/kg/day) for 10 days. Then cisplatin (50 mg/kg/day) was injected in mice of CP group and CU + CP group, while those in control group were given the same volume of NS. Five days after injection all mice were killed and liver dissected. The hepatic morphological structures were observed under light microscope and transmission electron microscope. The results indicated that CU alleviated the hepatic histopathological damages induced by cisplatin, which included declined body weight, vacuolated cytoplasm and blurred liver trabecular structure. Moreover, no hepatic ultrastructural damages were observed in the CU protective group with condensed and marginated nuclear chromatin, bile canaliculi outstreched and bile deposited.
authors: Zhongnan Hospital of Wuhan University, The Second College of Clinical Medicine of Wuhan University , Wuhan, Hubei , People's Republic of China .
authors: Ying
authors: Y
authors: Wang
authors: Peng-Chao
authors: PC
authors: Hu
authors: Fang-Fang
authors: FF
authors: Gao
authors: Jia-Wei
authors: JW
authors: Lv
authors: Shuai
authors: S
authors: Xu
authors: Chang-Chun
authors: CC
authors: Kuang
authors: Lei
authors: L
authors: Wei
authors: Jing-Wei
authors: JW
authors: Zhang
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002945:Cisplatin / Q000633:toxicity*; D003474:Curcumin / Q000494:pharmacology*; D022781:Hepatocytes / Q000187:drug effects / Q000648:ultrastructure*; D007668:Kidney / Q000648:ultrastructure*; D008297:Male; D051379:Mice
chemical_list: D000975:Antioxidants; D003474:Curcumin; D002945:Cisplatin
keywords: Curcumin; cisplatin; hepatotoxicity; ultrastructure