title: Chemical constituents of Abies nukiangensis.
abstract: During a survey on chemical constituents of Abies nukiangensis, seven previously unreported compounds, including six triterpenes (1-6) and one phenol (7) were isolated and characterized, together with 37 known miscellaneous chemical constituents. The structures of compounds 1-7 were established mainly by extensive analysis of the 1D and 2D NMR, as well as HRMS data. The absolute configurations of compounds 1 and 8 were confirmed unambiguously by the Cu-Kα X-ray crystallography. Compounds 3 and 8-10 showed significant anti-hepatitis C virus effects with EC50 values of 3.73, 2.67, 1.33 and 2.25μM, respectively.
authors: School of Pharmacy, Shanghai JiaoTong University, 800 Dongchuan Road, Shanghai 200240, China; Division of Material Science & Quality Test, Shanghai Institute of Measurement and Testing Technology, Shanghai 201203, China.
authors: Yong-Li
authors: YL
authors: Li
authors: School of Pharmacy, Shanghai JiaoTong University, 800 Dongchuan Road, Shanghai 200240, China.
authors: Yan-Xia
authors: YX
authors: Gao
authors: School of Pharmacy, Shanghai JiaoTong University, 800 Dongchuan Road, Shanghai 200240, China.
authors: Hui-Zi
authors: HZ
authors: Jin
authors: School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
authors: Lei
authors: L
authors: Shan
authors: Department of Infectious Diseases, Changhai Hospital, Second Military Medical University, Shanghai 200433, China; Artie McFerrin Department of Chemical Engineering, Texas A&M University, TX 77843, USA.
authors: Xue-Song
authors: XS
authors: Liang
authors: School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
authors: Xi-Ke
authors: XK
authors: Xu
authors: Luxembourg Public Research Centre for Health (CRP-Sante), 84 Val Fleuri, L-1526 Luxembourg, Luxembourg. Electronic address: xianwen.yang@crp-sante.lu.
authors: Xian-Wen
authors: XW
authors: Yang
authors: Luxembourg Public Research Centre for Health (CRP-Sante), 84 Val Fleuri, L-1526 Luxembourg, Luxembourg.
authors: Ning
authors: N
authors: Wang
authors: Luxembourg Public Research Centre for Health (CRP-Sante), 84 Val Fleuri, L-1526 Luxembourg, Luxembourg.
authors: Andre
authors: A
authors: Steinmetz
authors: Artie McFerrin Department of Chemical Engineering, Texas A&M University, TX 77843, USA.
authors: Zhilei
authors: Z
authors: Chen
authors: School of Pharmacy, Shanghai JiaoTong University, 800 Dongchuan Road, Shanghai 200240, China; School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China. Electronic address: wdzhangy@hotmail.com.
authors: Wei-Dong
authors: WD
authors: Zhang
mesh_terms: D028202:Abies / Q000737:chemistry*; D000998:Antiviral Agents / Q000737:chemistry* / Q000302:isolation & purification; D045744:Cell Line, Tumor; D016174:Hepacivirus / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D000998:Antiviral Agents; D010636:Phenols; D010936:Plant Extracts; D014315:Triterpenes
keywords: Abies nukiangensis; Abietoideae; Cu-Kα X-ray crystallography; Hepatitis C virus (HCV); Pinaceae; Triterpenoids