title: Prediction of histological types of endometrial cancer by endometrial cytology.
abstract: OBJECTIVE
  Few studies have examined the accuracy of preoperative endometrial cytology in diagnosing low- and high-risk histology in women with endometrial cancer (EC). This single-institutional retrospective study compared the accuracy of endometrial cytology and biopsy in preoperatively predicting low-risk and high-risk histology of EC.
  
  
  METHODS
  Between January 2006 and March 2013, 198 women with EC were examined by endometrial cytology, endometrial biopsy and hysterectomy specimen in National Kyushu Cancer Center. Among these women, 110 had endometrial cytology samples available to compare with endometrial biopsy, and were enrolled in our study (mean age ± standard deviation: 59.57 ± 10.32 years). Single-use plastic endometrial suction curettes were used in 12 of the 110 cases and thin metallic curettes for the rest.
  
  
  RESULTS
  For type 2 EC, which includes grade 3 endometrioid adenocarcinoma and non-endometrioid histology, biopsy was 67.6% sensitive (25/37) and 84.9% specific (62/73); whereas cytology was 70.3% sensitive (26/37) and 91.8% specific (67/73). Cytology precisely diagnosed only one of 14 cases of serous carcinoma, but it diagnosed 11 of the 14 cases as type 2 EC, and its accuracy in distinguishing EC types was not inferior to endometrial biopsy (10/14). For EC, 9.1% (10/110) were unevaluable using biopsy, significantly more than the 0% (0/110) by cytology (P = 0.002).
  
  
  CONCLUSIONS
  Although preoperative prediction of serous carcinoma was difficult, endometrial cytology had a higher evaluable rate for EC types. Endometrial cytology may complement endometrial biopsy in preoperative women with EC.
authors: Gynecology Service, National Kyushu Cancer Center, Fukuoka, Japan.
authors: Masao
authors: M
authors: Okadome
authors: Toshiaki
authors: T
authors: Saito
authors: Naoko
authors: N
authors: Nishiyama
authors: Kazuya
authors: K
authors: Ariyoshi
authors: Kumi
authors: K
authors: Shimamoto
authors: Takako
authors: T
authors: Shimada
authors: Keisuke
authors: K
authors: Kodama
authors: Shogo
authors: S
authors: Imamura
authors: Ken-ichi
authors: K
authors: Nishiyama
authors: Kenichi
authors: K
authors: Taguchi
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002173:Cancer Care Facilities; D002277:Carcinoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D015331:Cohort Studies; D003581:Cytodiagnosis; D003937:Diagnosis, Differential; D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D004717:Endometrium / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007564:Japan; D008875:Middle Aged; D060787:Neoplasm Grading; D011237:Predictive Value of Tests; D012189:Retrospective Studies
keywords: endometrial cytology; endometrial neoplasms/pathology/surgery; endometrial sampling; neoplasm grading; preoperative care