title: Overexpression of autophagy-related 16-like 1 in patients with oral squamous cell carcinoma.
abstract: Dyregulation of autophagy has been reported in various human cancers including oral squamous cell carcinoma (OSCC). The objective of this study was to link expression of autophagy-related 16-like 1 (ATG16L1), a protein essential for autophagosome formation, to clinical outcome in a cohort of 90 OSCC patients. Expression level of ATG16L1 was assessed by immunohistochemistry and an immunoreactivity score (IRS), ranging from 0 to 9, was assigned to each case. The results were correlated with clinicopathological parameters and outcome of patients. Twenty-seven patients (30%) exhibited ATG16L1 overexpression as indicated by an IRS of 9. Overexpression of ATG16L1 was significantly associated with disease stage (p = 0.001), size (p = 0.031) of the tumor, lymph node metastasis (p = 0.004), and histological grade (p = 0.038). ATG16L1 overexpression significantly affected the overall survival (p = 0.020) and time to recurrence (p = 0.031) of OSCC patients in Kaplan-Meier analysis. The present study suggested that ATG16L1 may be used as a biomarker for selecting OSCC patients with a more aggressive phenotype.
authors: Department of Radiation Oncology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors: Jen-Yang
authors: JY
authors: Tang
authors: Edward
authors: E
authors: Hsi
authors: Ya-Chun
authors: YC
authors: Huang
authors: Nicholas Chung-Heng
authors: NC
authors: Hsu
authors: Wen-Chi
authors: WC
authors: Yang
authors: Hsueh-Wei
authors: HW
authors: Chang
authors: Chee-Yin
authors: CY
authors: Chai
authors: Pei-Yi
authors: PY
authors: Chu
mesh_terms: D000368:Aged; D000071183:Autophagy-Related Proteins; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D015331:Cohort Studies; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics / Q000502:physiology*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D009367:Neoplasm Staging; D010641:Phenotype; D011379:Prognosis; D012189:Retrospective Studies; D012720:Severity of Illness Index; D015996:Survival Rate; D015854:Up-Regulation / Q000235:genetics / Q000502:physiology*
chemical_list: C518959:ATG16L1 protein, human; D000071183:Autophagy-Related Proteins; D014408:Biomarkers, Tumor; D002352:Carrier Proteins