title: Catalytic asymmetric assembly of C3-monosubstituted chiral carbazolones and concise formal synthesis of (-)-aspidofractinine: application of enantioselective Pd-catalyzed decarboxylative protonation of carbazolones.
abstract: The first method for the asymmetric synthesis of C3-monosubstituted chiral carbazolones, structural motifs common in medicinal chemistry, has been achieved using Pd-catalyzed decarboxylative protonation of carbazolones. This methodology has been applied to the first catalytic enantioselective formal synthesis of (-)-aspidofractinine with step economy and simplicity.
authors: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University , Kunming, Yunnan 650091, P. R. China.
authors: Ruirui
authors: R
authors: Zhao
authors: Zhongwen
authors: Z
authors: Sun
authors: Mingjie
authors: M
authors: Mo
authors: Fangzhi
authors: F
authors: Peng
authors: Zhihui
authors: Z
authors: Shao
mesh_terms: D002227:Carbazoles / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006865:Hydrogenation; D026121:Indole Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D002227:Carbazoles; D026121:Indole Alkaloids; C552319:aspidofractinine; D010165:Palladium