title: Genetic diversity of HLA-DRB1 alleles in the Tujia population of Wufeng, Hubei Province, China.
abstract: We established a genetic database by investigating human leukocyte antigen (HLA)-DRB1 allelic frequencies in a disease-association study in the Tujia population in Wufang, Hubei, China. The allele frequencies of the HLA-DRB1 locus in 262 healthy, unrelated Tujia individuals living in the Wufeng region of the Hubei Province were analyzed using the Luminex HLA sequence-specific oligonucleotide method with a WAKFlow HLA typing kit. A total of 13 alleles were detected at the HLA-DRB1 locus. HLA-DRB1*09 was the most common allele (22.52%), followed by DRB1*08 and DRB1*15 (11.07%), and DRB1*12 and DRB1*04 (10.69%). These data were compared with the results obtained for 10 other ethnic groups living in other regions as well as to Han groups using neighbor-joining dendrograms and principal component analysis. The results showed that the Tujia population has a close genetic relationship with the Middle Han population at the HLA-DRB1 locus. This information will be useful for HLA-DRB1-linked disease-association studies.
authors: Institute of Virology, Medical School of Wuhan University, Wuhan, Hubei, China.
authors: X P
authors: XP
authors: Qiu
authors: Institute of Virology, Medical School of Wuhan University, Wuhan, Hubei, China.
authors: L
authors: L
authors: Zhang
authors: The Clinical Laboratory, Wuhan Hospital, Wuhan, China.
authors: F Y
authors: FY
authors: Zeng
authors: Medical School of Hubei University of Science and Technology, Hubei, China.
authors: Y
authors: Y
authors: Wen
authors: Wuhan Nursing Home Hot Spring Rehabilitation Sanitarium Area, Xianning, Hubei, China.
authors: C
authors: C
authors: Li
authors: Institute of Virology, Medical School of Wuhan University, Wuhan, Hubei, China.
authors: L X
authors: LX
authors: Qiu
authors: Department of Medicine and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
authors: D X
authors: DX
authors: Cheng
authors: Institute of Virology, Medical School of Wuhan University, Wuhan, Hubei, China qiuxp8488@sohu.com.
authors: X X
authors: XX
authors: Wu
mesh_terms: D000483:Alleles; D002681:China; D005006:Ethnicity; D005260:Female; D015870:Gene Expression; D005787:Gene Frequency; D056426:Genetic Loci; D014644:Genetic Variation; D059811:HLA-DRB1 Chains / Q000145:classification / Q000235:genetics*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000378:metabolism; D008297:Male; D010802:Phylogeny; D011203:Poverty; D025341:Principal Component Analysis
chemical_list: D059811:HLA-DRB1 Chains