title: Label-free immunodetection of the cancer biomarker CA125 using high-Δn liquid crystals.
abstract: A label-free and array-based optical liquid-crystal (LC) immunodetection technique for the detection of CA125 antigen, a protein biomarker most frequently used for ovarian cancer detection, was demonstrated with a nematic LC with larger birefringence (Δn) to promote sensitivity in detecting biomolecules. The LC-based immunodetection offers an alternative and sensitive approach for the detection of biomarker proteins, with the potential of replacing conventional immunoassays used in biochemical studies and clinical laboratories.
authors: National Chiao Tung University, College of Photonics, Tainan 71150, Taiwan.
authors: Hui-Wen
authors: HW
authors: Su
authors: National Chiao Tung University, College of Photonics, Tainan 71150, Taiwan.
authors: Yun-Han
authors: YH
authors: Lee
authors: Chang Jung Christian University, Department of Bioscience Technology, Tainan 71101, Taiwan.
authors: Mon-Juan
authors: MJ
authors: Lee
authors: Chang Jung Christian University, Graduate Institute of Medical Sciences, Tainan 71101, Taiwan.
authors: Yi-Chiang
authors: YC
authors: Hsu
authors: National Chiao Tung University, College of Photonics, Tainan 71150, Taiwan.
authors: Wei
authors: W
authors: Lee
mesh_terms: D000818:Animals; D055910:Antibodies, Immobilized / Q000737:chemistry / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000378:metabolism; D018394:CA-125 Antigen / Q000032:analysis* / Q000378:metabolism; D002417:Cattle; D015200:Fluoroimmunoassay / Q000295:instrumentation* / Q000379:methods*; D006801:Humans; D050866:Liquid Crystals / Q000737:chemistry*; D012710:Serum Albumin, Bovine
chemical_list: D055910:Antibodies, Immobilized; D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D012710:Serum Albumin, Bovine