title: New links between mRNA polyadenylation and diverse nuclear pathways.
abstract: The 3' ends of most eukaryotic messenger RNAs must undergo a maturation step that includes an endonuc-leolytic cleavage followed by addition of a polyadenylate tail. While this reaction is catalyzed by the action of only two enzymes it is supported by an unexpectedly large number of proteins. This complexity reflects the necessity of coordinating this process with other nuclear events, and growing evidence indicates that even more factors than previously thought are necessary to connect 3' processing to additional cellular pathways. In this review we summarize the current understanding of the molecular machinery involved in this step of mRNA maturation, focusing on new core and auxiliary proteins that connect polyadenylation to splicing, DNA damage, transcription and cancer.
authors: Columbia University, Department of Biological Sciences, New York NY, 10027, USA.
authors: Dafne Campigli
authors: DC
authors: Di Giammartino
authors: Columbia University, Department of Biological Sciences, New York NY, 10027, USA.
authors: James L
authors: JL
authors: Manley
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D026723:Polyadenylation; D054645:Protein Phosphatase 1 / Q000235:genetics / Q000378:metabolism*; D026721:RNA 3' End Processing / Q000502:physiology; D012326:RNA Splicing; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases
chemical_list: D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D012333:RNA, Messenger; D029701:Saccharomyces cerevisiae Proteins; C486022:WDR33 protein, human; C098584:RBBP6 protein, human; D044767:Ubiquitin-Protein Ligases; C092048:GLC7 protein, S cerevisiae; D054645:Protein Phosphatase 1
keywords: 3′ end processing; cleavage; polyadenylation; pre-mRNA