title: Intestinal nuclear receptors in HDL cholesterol metabolism.
abstract: The intestine plays a pivotal role in cholesterol homeostasis by functioning as an absorptive and secretory organ in the reverse cholesterol transport pathway. Enterocytes control cholesterol absorption, apoAI synthesis, HDL biogenesis, and nonbiliary cholesterol fecal disposal. Thus, intestine-based therapeutic interventions may hold promise in the management of diseases driven by cholesterol overload. Lipid-sensing nuclear receptors (NRs) are highly expressed in the intestinal epithelium and regulate transcriptionally the handling of cholesterol by the enterocytes. Here, we discuss the NR regulation of cholesterol fluxes across the enterocytes with special emphasis on NR exploitation as a bona fide novel HDL-raising strategy.
authors: Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Tumori "Giovanni Paolo II", 70124 Bari, Italy.
authors: Chiara
authors: C
authors: Degirolamo
authors: Clinica Medica "Cesare Frugoni", Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
authors: Carlo
authors: C
authors: Sabbà
authors: Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Tumori "Giovanni Paolo II", 70124 Bari, Italy Clinica Medica "Cesare Frugoni", Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
authors: Antonio
authors: A
authors: Moschetta
mesh_terms: D000818:Animals; D008076:Cholesterol, HDL / Q000378:metabolism*; D020895:Enterocytes / Q000378:metabolism; D005786:Gene Expression Regulation; D006706:Homeostasis; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000166:cytology; D018160:Receptors, Cytoplasmic and Nuclear / Q000737:chemistry / Q000378:metabolism*
chemical_list: D008076:Cholesterol, HDL; D018160:Receptors, Cytoplasmic and Nuclear
keywords: atherosclerosis; gene expression; high density lipoprotein; lipoprotein; transcription; transport