title: A clinically useful approach to enhance immunological memory and antitumor immunity.
abstract: Persistence of vaccine-induced immune responses, not the initial magnitude, best correlates with protective antitumor immunity. In mice, oligonucleotide aptamer-targeted siRNA inhibition of mammalian target of rapamycin (mTOR) activity in activated CD8+ T cells promotes their differentiation into functionally competent memory cells leading to enhanced antitumor immunity, a protective effect superior to that of non-targeted administration of the mTOR inhibitor rapamycin.
authors: Department of Microbiology & Immunology; Dodson Interdisciplinary Immunotherapy Institute; Sylvester Comprehensive Cancer Center; Miller School of Medicine; University of Miami; Miami, FL USA.
authors: Alex
authors: A
authors: Berezhnoy
authors: Department of Microbiology & Immunology; Dodson Interdisciplinary Immunotherapy Institute; Sylvester Comprehensive Cancer Center; Miller School of Medicine; University of Miami; Miami, FL USA.
authors: Anugraha
authors: A
authors: Rajagopalan
authors: Department of Microbiology & Immunology; Dodson Interdisciplinary Immunotherapy Institute; Sylvester Comprehensive Cancer Center; Miller School of Medicine; University of Miami; Miami, FL USA.
authors: Eli
authors: E
authors: Gilboa
keywords: 4-1BB costimulation; T cell memory; Tumor immunity; aptamers; mTOR