title: Recent progress in sodium channel modulators for pain.
abstract: Voltage-gated sodium channels (Navs) are an important family of transmembrane ion channel proteins and Nav drug discovery is an exciting field. Pharmaceutical investment in Navs for pain therapeutics has expanded exponentially due to genetic data such as SCN10A mutations and an improved ability to establish an effective screen sequence for example IonWorks Barracuda®, Synchropatch® and Qube®. Moreover, emerging clinical data (AZD-3161, XEN402, CNV1014802, PF-05089771, PF-04531083) combined with recent breakthroughs in Nav structural biology pave the way for a future of fruitful prospective Nav drug discovery.
authors: Worldwide Medicinal Chemistry, Pfizer Neusentis, The Portway Building, Granta Park, Great Abington, Cambridge CB21 6GS, UK. Electronic address: sharan.bagal@pfizer.com.
authors: Sharan K
authors: SK
authors: Bagal
authors: Electrophysiology, Pfizer Neusentis, 4222 Emperor Blvd., Durham, NC, USA.
authors: Mark L
authors: ML
authors: Chapman
authors: Chemistry, Pfizer Neusentis, 4222 Emperor Blvd., Durham, NC, USA.
authors: Brian E
authors: BE
authors: Marron
authors: Electrophysiology, Pfizer Neusentis, The Portway Building, Granta Park, Great Abington, Cambridge CB21 6GS, UK.
authors: Rebecca
authors: R
authors: Prime
authors: Worldwide Medicinal Chemistry, Pfizer Neusentis, The Portway Building, Granta Park, Great Abington, Cambridge CB21 6GS, UK.
authors: R Ian
authors: RI
authors: Storer
authors: Worldwide Medicinal Chemistry, Pfizer Neusentis, The Portway Building, Granta Park, Great Abington, Cambridge CB21 6GS, UK.
authors: Nigel A
authors: NA
authors: Swain
mesh_terms: D000818:Animals; D055808:Drug Discovery; D006801:Humans; D010146:Pain / Q000188:drug therapy*; D026941:Sodium Channel Blockers / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use*; D061566:Voltage-Gated Sodium Channels / Q000737:chemistry / Q000378:metabolism*
chemical_list: D026941:Sodium Channel Blockers; D061566:Voltage-Gated Sodium Channels
keywords: Electrophysiology screening; Sodium channel drugs; Sodium channel structure; Sodium channel toxins; Voltage-gated sodium channels