title: Experimental therapy with azoles against Candida guilliermondii.
abstract: We evaluated the in vitro killing activity of voriconazole (VRC) and posaconazole (PSC) against two clinical isolates of Candida guilliermondii. The two drugs showed fungistatic activity against both isolates and were effective in reducing kidney fungal burden in a neutropenic murine model of disseminated candidiasis in infected mice. PSC was significantly more effective than VRC against one of the strains. The serum levels of PSC and VRC were above the corresponding MICs for these isolates.
authors: Unitat de Microbiologia and Unitat d'Anatomia Patològica, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain.
authors: Marta
authors: M
authors: Sanchis
authors: Unitat de Microbiologia and Unitat d'Anatomia Patològica, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain.
authors: Francisco Javier
authors: FJ
authors: Pastor
authors: Unitat de Microbiologia and Unitat d'Anatomia Patològica, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain.
authors: Javier
authors: J
authors: Capilla
authors: Fungus Testing Laboratory, University of Texas Health Science Center, San Antonio, Texas, USA.
authors: Deanna A
authors: DA
authors: Sutton
authors: Fungus Testing Laboratory, University of Texas Health Science Center, San Antonio, Texas, USA.
authors: Annette W
authors: AW
authors: Fothergill
authors: Unitat de Microbiologia and Unitat d'Anatomia Patològica, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain josep.guarro@urv.cat.
authors: Josep
authors: J
authors: Guarro
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D001393:Azoles / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D014230:Triazoles / Q000494:pharmacology; D065819:Voriconazole / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D001393:Azoles; D014230:Triazoles; C101425:posaconazole; D065819:Voriconazole