title: Maltodextrins as chiral selectors in CE: molecular structure effect of basic chiral compounds on the enantioseparation.
abstract: Prediction of chiral separation for a compound using a chiral selector is an interesting and debatable work. For this purpose, in this study 23 chiral basic drugs with different chemical structures were selected as model solutes and the influence of their chemical structures on the enantioseparation in the presence of maltodextrin (MD) as chiral selector was investigated. For chiral separation, a 100-mM phosphate buffer solution (pH 3.0) containing 10% (w/v) MD with dextrose equivalent (DE) of 4-7 as chiral selector at the temperature of 25°C and voltage of 20 kV was used. Under this condition, baseline separation was achieved for nine chiral compounds and partial separation was obtained for another six chiral compounds while no enantioseparation was obtained for the remaining eight compounds. The results showed that the existence of at least two aromatic rings or cycloalkanes and an oxygen or nitrogen atom or -CN group directly bonded to the chiral center are necessary for baseline separation. With the obtained results in this study, chiral separation of a chiral compound can be estimated with MD-modified capillary electrophoresis before analysis. This prediction will minimize the number of preliminary experiments required to resolve enantiomers and will save time and cost.
authors: Department of Pure Chemistry, Faculty of Chemistry, Shahid Beheshti University, G. C., P.O. Box 19396-4716, Evin, Tehran, I.R., Iran.
authors: Hadi
authors: H
authors: Tabani
authors: Ali Reza
authors: AR
authors: Fakhari
authors: Saeed
authors: S
authors: Nojavan
keywords: capillary electrophoresis; chiral separation; maltodextrin; prediction