title: Effect of locally applied bFGF on implant stability: biomechanical evaluation of 2 different implant surfaces in rabbits.
abstract: OBJECTIVE
  The aim of this study was to evaluate the implant stability with the addition of local application of basic fibroblast growth factor (bFGF) during the osseointegration of 2 different dental implant surfaces using rabbit tibia model.
  
  
  METHODS
  Fifty-six dental implants, 28 of hydrophilic surface (SLActive) and 28 of hydrophobic surface (OsseoSpeed), were placed in 14 mature New Zealand rabbits. The rabbits each received both SLActive and OsseoSpeed implants per tibia, and bFGF was applied locally on 1 randomly selected tibia. Half of the subjects were killed at the fourth week of healing period, and the other half were killed at the twelfth week. Stabilization was assessed using resonance frequency analysis (RFA) and removal torque value (RTV).
  
  
  RESULTS
  The local application of bFGF was found to enhance osseointegration, especially at the fourth week of healing period after application (P = 0.046). RFAs and RTVs were found to be higher in bFGF-treated implant with hydrophilic surfaces when compared with both bFGF-treated hydrophobic implants and nontreated hydrophilic controls.
  
  
  CONCLUSIONS
  Local application of bFGF seems to increase the stabilization values in implants with hydrophilic surfaces and those with hydrophobic surfaces.
authors: *Private Practice, Oral and Maxillofacial Surgery, Ankara, Turkey. †Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ankara University, Ankara, Turkey. ‡Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Ufuk University, Ankara, Turkey. §Associate Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kirikkale University, Kirikkale, Turkey. ‖Assistant Professor, Department of Oral and Maxillofacial Surgery, GATA Haydarpasa Teaching Hospital, Istanbul, Turkey.
authors: Yasemin
authors: Y
authors: Kartal
authors: Cahit
authors: C
authors: Ucok
authors: Ozkan
authors: O
authors: Ozgul
authors: İsmail
authors: İ
authors: Doruk Kocyigit
authors: Berkay
authors: B
authors: Tolga Suer
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D015921:Dental Implants; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage*; D023421:Models, Animal; D011817:Rabbits; D013499:Surface Properties
chemical_list: D015921:Dental Implants; D016222:Fibroblast Growth Factor 2