title: Genome evolution in trypanosomatid parasites.
abstract: A decade of genome sequencing has transformed our understanding of how trypanosomatid parasites have evolved and provided fresh impetus to explaining the origins of parasitism in the Kinetoplastida. In this review, I will consider the many ways in which genome sequences have influenced our view of genomic reduction in trypanosomatids; how species-specific genes, and the genomic domains they occupy, have illuminated the innovations in trypanosomatid genomes; and how comparative genomics has exposed the molecular mechanisms responsible for innovation and adaptation to a parasitic lifestyle.
authors: Department of Infection Biology, Institute of Infection and Global Health,University of Liverpool,Liverpool Science Park Ic2, 146 Brownlow Hill, Liverpool L3 5RF,UK.
authors: Andrew P
authors: AP
authors: Jackson
mesh_terms: D001483:Base Sequence; D005075:Biological Evolution; D018503:Genome, Protozoan / Q000235:genetics*; D023281:Genomics; D016830:Kinetoplastida / Q000235:genetics*; D007891:Leishmania / Q000235:genetics; D010802:Phylogeny; D013045:Species Specificity; D014345:Trypanosoma / Q000235:genetics
keywords: parasitism