title: Investigation of temporal vascular effects induced by focused ultrasound treatment with speckle-variance optical coherence tomography.
abstract: Focused ultrasound (FUS) can be used to locally and temporally enhance vascular permeability, improving the efficiency of drug delivery from the blood vessels into the surrounding tissue. However, it is difficult to evaluate in real time the effect induced by FUS and to noninvasively observe the permeability enhancement. In this study, speckle-variance optical coherence tomography (SVOCT) was implemented for the investigation of temporal effects on vessels induced by FUS treatment. With OCT scanning, the dynamic change in vessels during FUS exposure can be observed and studied. Moreover, the vascular effects induced by FUS treatment with and without the presence of microbubbles were investigated and quantitatively compared. Additionally, 2D and 3D speckle-variance images were used for quantitative observation of blood leakage from vessels due to the permeability enhancement caused by FUS, which could be an indicator that can be used to determine the influence of FUS power exposure. In conclusion, SVOCT can be a useful tool for monitoring FUS treatment in real time, facilitating the dynamic observation of temporal effects and helping to determine the optimal FUS power.
authors: Department of Electrical Engineering, School of Electrical and Computer Engineering, College of Engineering, Chang Gung University, 259, Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan, 33302 Taiwan ; Graduate Institute of Electro-Optical Engineering, School of Electrical and Computer Engineering, College of Engineering, Chang Gung University, 259, Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan, 33302 Taiwan.
authors: Meng-Tsan
authors: MT
authors: Tsai
authors: Department of Electrical Engineering, School of Electrical and Computer Engineering, College of Engineering, Chang Gung University, 259, Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan, 33302 Taiwan.
authors: Feng-Yu
authors: FY
authors: Chang
authors: Department of Electrical Engineering, School of Electrical and Computer Engineering, College of Engineering, Chang Gung University, 259, Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan, 33302 Taiwan.
authors: Cheng-Kuang
authors: CK
authors: Lee
authors: Department of Electrical Engineering, School of Electrical and Computer Engineering, College of Engineering, Chang Gung University, 259, Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan, 33302 Taiwan.
authors: Cihun-Siyong Alex
authors: CS
authors: Gong
authors: Department of Electrical Engineering, School of Electrical and Computer Engineering, College of Engineering, Chang Gung University, 259, Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan, 33302 Taiwan.
authors: Yu-Xiang
authors: YX
authors: Lin
authors: Department of Electrical Engineering, School of Electrical and Computer Engineering, College of Engineering, Chang Gung University, 259, Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan, 33302 Taiwan.
authors: Jiann-Der
authors: JD
authors: Lee
authors: Department of Dermatology, Chang Gung Memorial Hospital, 5 Fusing Street, Kwei-Shan, Tao-Yaun 33302, Taiwan.
authors: Chih-Hsun
authors: CH
authors: Yang
authors: Department of Electrical Engineering, School of Electrical and Computer Engineering, College of Engineering, Chang Gung University, 259, Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan, 33302 Taiwan.
authors: Hao-Li
authors: HL
authors: Liu
keywords: (110.4500) Optical coherence tomography; (170.2655) Functional monitoring and imaging; (170.3880) Medical and biological imaging; (290.1350) Backscattering