title: Synthesis and evaluation of novel pyrroles and pyrrolopyrimidines as anti-hyperglycemic agents.
abstract: A series of pyrrole and pyrrolopyrimidine derivatives were examined for their in vivo antihyperglycemic activity. Compounds Ia-c,e, and IVg showed promising antihyperglycemic activity equivalent to a well-known standard antihyperglycemic drug, Glimepiride (Amaryl, 4 mg/kg). In this paper, we examine and discuss the structure-activity relationships and antihyperglycemic activity of these compounds.
authors: Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Ein-Helwan, Helwan, Cairo 11795, Egypt.
authors: M S
authors: MS
authors: Mohamed
authors: Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Helwan University, Ein-Helwan, Helwan, Cairo 11795, Egypt.
authors: S A
authors: SA
authors: Ali
authors: Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Helwan University, Ein-Helwan, Helwan, Cairo 11795, Egypt.
authors: D H A
authors: DH
authors: Abdelaziz
authors: Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Ein-Helwan, Helwan, Cairo 11795, Egypt.
authors: Samar S
authors: SS
authors: Fathallah
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D015195:Drug Design; D006943:Hyperglycemia / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008956:Models, Chemical; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D013395:Sucrose / Q000737:chemistry; D013453:Sulfonylurea Compounds / Q000737:chemistry; D013696:Temperature
chemical_list: D007004:Hypoglycemic Agents; D011743:Pyrimidines; D011758:Pyrroles; D013453:Sulfonylurea Compounds; D013395:Sucrose; C057619:glimepiride