title: A neutron dynamic therapy with a boron tracedrug UTX-51 using a compact neutron generator.
abstract: OBJECTIVE
  We are developing a neutron dynamic therapy (NDT) with boron tracedrugs for a new mechanical-clearance treatment of pathotoxic misfolded, aggregated, and self-propagating prion-associated disease proteins. We present a compact neutron generator-based NDT using a boron tracedrug UTX-51. Our NDT is based on the weak thermal neutron-bombarded destructive action of UTX-51 on bovine serum albumin (BSA) using the neutron beams produced from a compact inertial electrostatic confinement fusion (IECF) neutron generator.
  
  
  RESULTS
  BSA as an NDT molecular target was subjected to thermal neutron irradiation for eight hours using a compact neutron generator. The sodium dodecyl sulfate-polyacrylamide gel electrophoresis pattern showed no protein band when 2 nmoles of BSA were irradiated with more than 100 nmoles of UTX-51, while BSA was not affected when irradiated without UTX-51.
  
  
  CONCLUSIONS
  For the first time, we have succeeded in the molecular destruction of a prion-disease model protein, BSA, by NDT with a boron tracedrug, UTX-51, using a compact neutron generator.
authors: Department of Life System, Institute of Technology and Science, Graduate School, The University of Tokushima, Tokushima, Japan hori@bio.tokushima-u.ac.jp hitoshi.hori@gmail.com.
authors: Hitoshi
authors: H
authors: Hori
authors: Department of Life System, Institute of Technology and Science, Graduate School, The University of Tokushima, Tokushima, Japan.
authors: Ryu
authors: R
authors: Tada
authors: Department of Life System, Institute of Technology and Science, Graduate School, The University of Tokushima, Tokushima, Japan.
authors: Yoshihiro
authors: Y
authors: Uto
authors: Institute of Advanced Energy, Kyoto University, Uji, Kyoto, Japan.
authors: Eiji
authors: E
authors: Nakata
authors: Institute of Advanced Energy, Kyoto University, Uji, Kyoto, Japan.
authors: Takashi
authors: T
authors: Morii
authors: Institute of Advanced Energy, Kyoto University, Uji, Kyoto, Japan.
authors: Kai
authors: K
authors: Masuda
mesh_terms: D001896:Boron Compounds / Q000627:therapeutic use*; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D009502:Neutrons; D012710:Serum Albumin, Bovine / Q000528:radiation effects
chemical_list: D001896:Boron Compounds; D012710:Serum Albumin, Bovine
keywords: NDT; Neutron dynamic therapy; UTX-51; boron tracedrug; compact neutron generator; curcuminoid