title: A comparison between gadofosveset trisodium and gadobenate dimeglumine for steady state MRA of the thoracic vasculature.
abstract: OBJECTIVE
  Retrospective comparison between gadofosveset trisodium and gadobenate dimeglumine steady state magnetic resonance angiography (SS-MRA) of the thoracic vasculature at 1.5T using signal-to-noise ratio (SNR) and vessel edge sharpness (ES) as markers of image quality.
  
  
  METHODS
  IRB approval was obtained. Twenty separate patients each underwent SS-MRA using high-resolution 3D ECG-triggered coronal IR-TFE at 1.5T approximately 3-4 minutes following 10 or 15 mL gadofosveset or 20 mL gadobenate. ROIs were placed in the right atrium, left ventricle, left atrium, ascending aorta, descending aorta, and right pulmonary artery to estimate SNR. Vessel ES was estimated as 20-80% rise distances from line intensity profiles in the left pulmonary vein, ascending aorta, and descending aorta. Data were analyzed using nonpaired Student's t-test (threshold for significance set at P < 0.05).
  
  
  RESULTS
  There was no significant difference in mean SNR for the gadofosveset or gadobenate groups (P values: 0.14 to 0.85). There was no significant difference in mean vessel ES for gadofosveset and gadobenate groups (P values: 0.17 to 0.78).
  
  
  CONCLUSIONS
  High quality thoracic SS-MRA can be achieved with gadobenate dimeglumine, similar to that achieved with the blood pool agent gadofosveset trisodium provided that imaging is initiated quickly (3-4 min) after contrast injection.
authors: Radiology, University of Washington, Seattle, WA 98195, USA.
authors: G Paul
authors: GP
authors: Camren
authors: Radiology, University of Washington, Seattle, WA 98195, USA.
authors: Gregory J
authors: GJ
authors: Wilson
authors: Radiology, University of Washington, Seattle, WA 98195, USA ; Aurora Medical Group, Milwaukee, WI 53045, USA.
authors: Vikram R
authors: VR
authors: Bamra
authors: Radiology, University of Washington, Seattle, WA 98195, USA.
authors: Khahn Q
authors: KQ
authors: Nguyen
authors: Radiology, University of Washington, Seattle, WA 98195, USA.
authors: Daniel S
authors: DS
authors: Hippe
authors: Radiology, University of Washington, Seattle, WA 98195, USA.
authors: Jeffrey H
authors: JH
authors: Maki
mesh_terms: D000328:Adult; D003287:Contrast Media / Q000008:administration & dosage*; D005682:Gadolinium / Q000008:administration & dosage*; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008536:Meglumine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008875:Middle Aged; D009942:Organometallic Compounds / Q000008:administration & dosage*; D011859:Radiography
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C064572:gadobenic acid; D008536:Meglumine; D005682:Gadolinium; C109932:gadofosveset trisodium