title: An Exploratory Case-Control Study on the Impact of IL-1 Gene Polymorphisms on Early Implant Failure.
abstract: BACKGROUND
  The association between IL-1 gene polymorphisms and peri-implantitis has been well documented. However, data on the association with early implant failure are scarce.
  
  
  OBJECTIVE
  The objective of this case-control study was to explore the impact of IL-1A (-889), IL-1B (-511), and IL-1B (+3,954) gene polymorphisms on early implant failure in Caucasians.
  
  
  METHODS
  Between September 2004 and August 2007, 461 patients were treated with dental implants at the University Hospital in Ghent, Belgium. Fourteen subjects of this patient group who had experienced one or more early implant failures (within 6 months from implant installation) were recruited as "cases." Fourteen "controls," matched in terms of age, gender, and smoking habits, with only surviving implants, were selected from the same patient group. Allele and genotype analysis was performed on the basis of a blood sample by Sanger sequencing of polymerase chain reaction products containing the IL-1A (-889), IL-1B (-511), and IL-1B (+3,954) gene polymorphisms.
  
  
  RESULTS
  A significant impact of the IL-1A (-889) T allele (p = .039) and the IL-1B (+3,954) T allele (p = .003) on early implant failure was demonstrated (odds ratios = 3.9 and 15.0, respectively). In addition, the genotypic distribution differed significantly between cases and controls for IL-1B (+3,954) (p = .015).
  
  
  CONCLUSIONS
  The IL-1B (+3,954) gene polymorphism seems to affect osseointegration. Additional case-control studies in larger patient groups are needed to confirm this observation.
authors: Department of Periodontology and Oral Implantology, Dental School, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.|Dental Medicine, Faculty of Medicine and Pharmacy, Free University of Brussels, Brussels, Belgium.
authors: Jan
authors: J
authors: Cosyn
authors: Department of Periodontology and Oral Implantology, Dental School, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
authors: Véronique
authors: V
authors: Christiaens
authors: Dental School, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
authors: Vincent
authors: V
authors: Koningsveld
authors: Center for Medical Genetics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
authors: Paul J
authors: PJ
authors: Coucke
authors: Unit of Oral Development and Applied Oral Histology, PaeCaMed Research Group, Dental School, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
authors: Peter
authors: P
authors: De Coster
authors: Center for Medical Genetics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
authors: Anne
authors: A
authors: De Paepe
authors: Periodontology and Oral Implantology, Dental School, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.|Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden.
authors: Hugo
authors: H
authors: De Bruyn
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D019232:Dental Restoration Failure; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D057873:Peri-Implantitis / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D007375:Interleukin-1
keywords: case-control study; implant failure; implant survival; interleukin; osseointegration; polymorphism; survival rate