title: Characterization of the physicochemical properties of KRK-701P.
abstract: KRK-701P is a broad-spectrum antibiotic with methicillin-resistant antibacterial activity. The objective of this preformulation study was to determine the physicochemical properties of KRK-701P. The n-octanol-to-water partition coefficients of KRK-701P were 0.448 at pH 4 and 2.546 at pH 8. One crystal form and one amorphous form of KRK-701P were isolated by recrystallization and characterized by differential scanning calorimetry, powder X-ray diffractometry and thermogravimetric analysis. After storage for 1 month at 0% RH (silica gel, 20 °C), 52% RH (saturated solution of Na2Cr2O7.2H2O/20 °C) and 95% RH (saturated solution of Na2HPO4/20 °C), the two forms were not transformed.
authors: College of Pharmacy, Duksung Women's University, 419, Ssangmun-Dong, Dobong-Gu, 132-714, Seoul, Korea.
authors: In Jeong
authors: IJ
authors: Bang
authors: Bong Jin
authors: BJ
authors: Kim
authors: Young Taek
authors: YT
authors: Sohn
mesh_terms: D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000737:chemistry* / Q000494:pharmacology; D002152:Calorimetry, Differential Scanning / Q000379:methods; D055598:Chemical Phenomena; D003460:Crystallization; D004355:Drug Stability; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D014961:X-Ray Diffraction / Q000379:methods
chemical_list: D000900:Anti-Bacterial Agents