title: Potential of cationic porphyrins for photodynamic treatment of cutaneous Leishmaniasis.
abstract: Four tetracationic porphyrins have been investigated for their ability to photo-inactivate Leishmania major promastigotes. Parallel photocytotoxicity assays against keratinocytes and macrophages show significant differences in activity between the microorganism and mammalian cells. Results suggest that it may be possible to photodynamically inactivate macrophages infected with Leishmania and the promastigote form of the microorganism, while minimising damage to surrounding tissue.
authors: Photobiology and Photomedicine Group, Department of Chemistry & Clinical Biosciences Institute, University of Hull, Kingston-upon-Hull HU6 7RX, United Kingdom.
authors: Carrie-Anne
authors: CA
authors: Bristow
authors: Photobiology and Photomedicine Group, Department of Chemistry & Clinical Biosciences Institute, University of Hull, Kingston-upon-Hull HU6 7RX, United Kingdom.
authors: Robert
authors: R
authors: Hudson
authors: Medway School of Pharmacy, The Universities of Kent and Greenwich at Medway, Kent ME4 4TB, United Kingdom.
authors: Timothy A
authors: TA
authors: Paget
authors: Photobiology and Photomedicine Group, Department of Chemistry & Clinical Biosciences Institute, University of Hull, Kingston-upon-Hull HU6 7RX, United Kingdom.
authors: Ross W
authors: RW
authors: Boyle