title: Serum lipid profiles, lipid ratios and Chronic Kidney Disease in a Chinese population.
abstract: OBJECTIVE
  To examine the association of serum lipids, lipid ratios with Chronic Kidney Disease (CKD) in a Chinese population.
  
  
  METHODS
  Data were drawn from a cross-sectional survey in China. CKD was defined as estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73m(2) or albuminuria-to-creatinine ratio (ACR) > 30 mg/g. Multivariable logistic regressions and multivariate regression models were used. Serum lipids and lipid ratios included total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), TG/HDL-C ratio, TC/HDL-C ratio and LDL-C/HDL-C ratio.
  
  
  RESULTS
  In men, only logarithm-transformed (log) TG was associated with CKD. The odds ratio (every SD increment) was 1.39 (95% CI 1.03-1.87, P = 0.03). In women, none of the serum lipids and lipid ratios was associated with CKD. Using multivariate regression models, it was shown that log TG and log TG/HDL-C were negatively correlated with eGFR (P < 0.05) in men and LDL-C and log LDL-C/HDL-C ratio were correlated with ACR in men. In female subjects, serum TC, log TG, log TG/HDL-C and log TC/HDL-C were negatively correlated with eGFR (P < 0.05). All of serum lipid profiles and lipid related ratio were not correlated with ACR in women.
  
  
  CONCLUSIONS
  Serum TG is the only suitable predictor for CKD in men. However, in women, none of serum lipids and lipid ratio can be used as a predictor for CKD. Log TG and log TG/HDL-C are negatively correlated with eGFR in both genders.
authors: Department of Nephrology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China. zhangliying926@126.com.
authors: Liying
authors: L
authors: Zhang
authors: Wanzai Hospital of Xiangzhou district, Zhuhai 519000, China. wzyyyzy@sina.com.
authors: Zhiyong
authors: Z
authors: Yuan
authors: Qianjin health service center of Tianhe district, Guangzhou 510000, China. dragonchw@sina.com.
authors: Wu
authors: W
authors: Chen
authors: Department of Nephrology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China. dqydqy386@sina.com.
authors: Shanying
authors: S
authors: Chen
authors: Department of Nephrology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China. pepsi84@163.com.
authors: Xinyu
authors: X
authors: Liu
authors: Department of Nephrology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China. lsky2008@yeah.net.
authors: Yan
authors: Y
authors: Liang
authors: Department of Nephrology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China. shaoxfei@126.com.
authors: Xiaofei
authors: X
authors: Shao
authors: Department of Nephrology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China. hequnzou@hotmail.com.
authors: Hequn
authors: H
authors: Zou
mesh_terms: D000368:Aged; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology* / Q000209:etiology
chemical_list: D008055:Lipids