title: Association of cyclin D1 variants with head and neck cancer susceptibility: evidence from a meta-analysis.
abstract: Whether cyclin D1 (CCND1) gene variants increase susceptibility to head and neck cancer (HNC) is undetermined. Therefore, we performed the present meta-analysis to systematically assess any possible association between CCND1 variants (G870A and G1722C) and HNC risk. Seventeen studies for CCND1 G870A and three studies for CCND1 G1722C were included. Overall, CCND1 polymorphisms (G870A and G1722C) had no association with increased HNC risk (p>0.05). In the subgroup analysis by smoking status, significantly increased HNC risk was found among smokers under allele contrast, homozygous comparison and recessive models (p<0.05), smoking carriers of A allele and AA genotype appearing at elevated risk. In conclusion, while there was overall a lack of any association between CCND1 polymorphisms (G870A and G1722C) and HNC risk, smokers carrying the A allele and AA genotype of the CCND1 G870A polymorphism may be susceptible to HNC development.
authors: Department of Otorhinolaryngology, Eye and ENT Hospital of Fudan University, Shanghai, China E-mail : yunfenh@163.com.
authors: Hai
authors: H
authors: Lin
authors: Lian
authors: L
authors: Fang
authors: Dong
authors: D
authors: Lin
mesh_terms: D019938:Cyclin D1 / Q000235:genetics*; D005260:Female; D019940:Genes, bcl-1 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006258:Head and Neck Neoplasms / Q000235:genetics*; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012907:Smoking / Q000235:genetics
chemical_list: D019938:Cyclin D1