title: Demographic events and evolutionary forces shaping European genetic diversity.
abstract: Europeans have been the focus of some of the largest studies of genetic diversity in any species to date. Recent genome-wide data have reinforced the hypothesis that present-day European genetic diversity is strongly correlated with geography. The remaining challenge now is to understand more precisely how patterns of diversity in Europe reflect ancient demographic events such as postglacial expansions or the spread of farming. It is likely that recent advances in paleogenetics will give us some of these answers. There has also been progress in identifying specific segments of European genomes that reflect adaptations to selective pressures from the physical environment, disease, and dietary shifts. A growing understanding of how modern European genetic diversity has been shaped by demographic and evolutionary forces is not only of basic historical and anthropological interest but also aids genetic studies of disease.
authors: Arizona Research Laboratories Division of Biotechnology, University of Arizona, Tucson, Arizona 85721.
authors: Krishna R
authors: KR
authors: Veeramah
authors: Department of Human Genetics, University of Chicago, Chicago, Illinois 60637.
authors: John
authors: J
authors: Novembre
mesh_terms: D005075:Biological Evolution; D004272:DNA, Mitochondrial / Q000235:genetics; D005060:Europe; D019143:Evolution, Molecular; D014644:Genetic Variation; D005828:Genetics, Population; D005843:Geography; D063426:Human Migration; D006801:Humans; D012641:Selection, Genetic; D044465:White People
chemical_list: D004272:DNA, Mitochondrial