title: An organocatalytic azide-aldehyde [3+2] cycloaddition: high-yielding regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles.
abstract: An organocatalytic azide-aldehyde [3+2] cycloaddition (organo-click) reaction of a variety of enolizable aldehydes is reported. The organo-click reaction is characterized by a high rate and regioselectivity, mild reaction conditions, easily available substrates with simple operation, and excellent yields with a broad spectrum of substrates. It constitutes an alternative to the previously known CuAAC, RuAAC, and IrAAC click reactions.
authors: Catalysis Laboratory, School of Chemistry, University of Hyderabad, Hyderabad-500 046 (India) http://chemistry.uohyd.ernet.in/∼dbr/. ramsc@uohyd.ernet.in, ramchary.db@gmail.com.
authors: Dhevalapally B
authors: DB
authors: Ramachary
authors: Adluri B
authors: AB
authors: Shashank
authors: S
authors: S
authors: Karthik
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D057930:Click Chemistry; D003300:Copper / Q000737:chemistry; D061565:Cycloaddition Reaction; D007495:Iridium / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry; D013237:Stereoisomerism; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000480:Alkynes; D001386:Azides; D014230:Triazoles; D007495:Iridium; D003300:Copper; D012428:Ruthenium
keywords: 1,2,3-triazoles; aldehydes; azides; click chemistry; organocatalysis