title: Laparoscopic Roux-en-Y gastric bypass for type 2 diabetes mellitus in nonobese Chinese patients.
abstract: BACKGROUND
  Although bariatric surgery performed for morbid obesity has been shown to significantly improve type 2 diabetes mellitus (T2DM), data on its effectiveness to improve T2DM in nonobese patients are scarce. The present pilot study evaluated the clinical effects of laparoscopic Roux-en-Y gastric bypass surgery (LRYGB) in Chinese T2DM patients with body mass index (BMI) ≤27.5 kg/m.
  
  
  METHODS
  A total of 68 consecutive patients with uncontrolled T2DM underwent LRYGB from May 2010 to March 2012. All patients were subjected to follow-up controls with anthropometric and metabolic indices at 1, 3, 6, and 12 months after surgery. Glycemic control was evaluated.
  
  
  RESULTS
  One year after the surgery, LRYGB resulted in 69.4%±52.2% excess weight loss percentage (%EWL), remission of T2DM in 80.9% of all the patients. In the group of T2DM patients with BMI≤27.5 kg/m (n=28), 9 (32.1%) cases showed T2DM remission, 10 (35.7%) showed glycemic control, 7 (25%) showed improvement, and 2 (7.1%) were unchanged. The change in BMI, waist circumference, and the plasma levels of FPG, HbA1C, triglycerides, HDL-C, and insulin were statistically significance at 1 year (P<0. 05). There was no perioperative mortality, but 6 (8.8%) patients experienced complications.
  
  
  CONCLUSIONS
  LRYGB resulted in significant weight loss and remission of T2DM in Chinese patients. Despite a lower response rate of surgery treatment compared with obese patients, T2DM patients with BMI≤27.5 kg/m still exhibited improvement and remission of T2DM. Diabetic patients should consider bariatric surgery, especially if traditional pharmacotherapy has not been effective. Longer follow-up is required for better evaluation.
authors: Departments of *Minimally Invasive Surgery †General Surgery ‡Neurology, The First Affiliated Hospital of Soochow University, Suzhou, China.
authors: Jun
authors: J
authors: Yin
authors: Lu
authors: L
authors: Xu
authors: Zhongqi
authors: Z
authors: Mao
authors: Xiaojun
authors: X
authors: Zhou
authors: Zheng
authors: Z
authors: Zhu
authors: Xin
authors: X
authors: Chen
authors: Jie
authors: J
authors: Sun
authors: Liqian
authors: L
authors: Mu
authors: Chengjuan
authors: C
authors: Peng
authors: Haixin
authors: H
authors: Qian
authors: Yi
authors: Y
authors: Yang
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D002096:C-Peptide / Q000378:metabolism; D002681:China / Q000208:ethnology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000208:ethnology / Q000601:surgery*; D015390:Gastric Bypass / Q000379:methods*; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D050356:Lipid Metabolism / Q000502:physiology; D008875:Middle Aged; D019990:Perioperative Care / Q000379:methods; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D002096:C-Peptide; D006442:Glycated Hemoglobin