title: Protective effect of omeprazole on gastric mucosal of cirrhotic portal hypertension rats.
abstract: OBJECTIVE
  To observe the protective effect of omeprazole on gastric mucosal of cirrhotic portal hypertension rats.
  
  
  METHODS
  All rats were randomly divided into normal control group, cirrhosis and treatment group. Thioacetamide was used to establish rat model of cirrhotic portal hypertension. The necrotic tissue of gastric mucosa ulcer focus, degree of neutrophils infiltration at the ulcer margin, portal pressure, portal venous flow, abdominal aortic pressure, abdominal aortic blood flow at front end, gastric mucosal blood flow (GMBF), glycoprotein (GP) of gastric mucosa, basal acid secretion, H(+)back -diffusion, gastric mucosal damage index, NO, prostaglandin E2(PGE2) and tumor necrosis factor-α (TNF-α) were determined respectively, and the pathological changes of gastric mucosa were also observed by microscope.
  
  
  RESULTS
  Compared with cirrhosis group and the control group, the ulcer bottom necrotic material, gastric neutrophil infiltration and UI of the treatment group were all decreased significantly (P<0.01), GMBF value, GP values, serum NO, PGE2, TNF-α were all significantly increased.
  
  
  CONCLUSIONS
  Omeprazole has an important protective effect on gastric mucosal and it can increase gastric mucosal blood flow and related to many factors.
authors: Department of Gastroenterology, Tangshan Workers' Hospital, Tangshan 063000, China.
authors: Wei
authors: W
authors: Gao
authors: Department of Gastroenterology, Tangshan Workers' Hospital, Tangshan 063000, China.
authors: Hai-Ying
authors: HY
authors: Li
authors: Department of Gastroenterology, Tangshan Workers' Hospital, Tangshan 063000, China.
authors: Li-Xin
authors: LX
authors: Wang
authors: Department of Gastroenterology, Tangshan Workers' Hospital, Tangshan 063000, China.
authors: Li-Jun
authors: LJ
authors: Hao
authors: Department of Gastroenterology, Tangshan Workers' Hospital, Tangshan 063000, China.
authors: Jian-Li
authors: JL
authors: Gao
authors: Department of Gastroenterology, Tangshan Workers' Hospital, Tangshan 063000, China.
authors: Rong-Juan
authors: RJ
authors: Zheng
authors: Department of Spleen and Stomach, Tangshan TCM Hospital, Tangshan 063003, China. Electronic address: Caichj326@sina.com.
authors: Chun-Jiang
authors: CJ
authors: Cai
authors: Department of Gastroenterology, Tangshan Workers' Hospital, Tangshan 063000, China. Electronic address: yanlingemail@163.com.
authors: Yan-Ling
authors: YL
authors: Si
mesh_terms: D000818:Animals; D005753:Gastric Mucosa / Q000737:chemistry / Q000187:drug effects* / Q000473:pathology; D006023:Glycoproteins / Q000032:analysis / Q000378:metabolism; D006975:Hypertension, Portal / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000378:metabolism*; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D009853:Omeprazole / Q000494:pharmacology*; D017082:Portal Pressure / Q000187:drug effects; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D006023:Glycoproteins; D020011:Protective Agents; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide; D009853:Omeprazole
keywords: Cirrhotic portal hypertension; Gastric mucosal injury; Omeprazole; Prostaglandins; Tumor necrosis factor-α