title: A panel of biomarkers for predicting response to postoperative RT for laryngeal cancer?
abstract: OBJECTIVE
  Postoperative radiotherapy (PORT) improves locoregional control and survival rates for patients with advanced laryngeal carcinoma (LSCC), but reported outcomes after PORT for LSCC vary considerably. Predictive markers (including biomarkers) are needed for LSCC to orient the choice of the most appropriate adjuvant therapy for individual patients. The aim of this study was to identify a panel of LSCC tissue markers (considering EGFR, mTOR, survivin, Bcl-2, angiogenin, endoglin [CD105], nm23-H1) capable of pinpointing patients at higher risk of recurrence among 33 LSCC cases treated with PORT.
  
  
  RESULTS
  Univariate analysis found 4 biomarkers (mTOR, nuclear survivin, CD105, non-nuclear nm23-H1) significantly associated with LSCC recurrence. A collinearity emerged between mTOR and CD105 expressions. The predictive role of two different panels (panel 1: mTOR, nuclear survivin, non-nuclear nm23-H1; panel 2: CD105, nuclear survivin, non-nuclear nm23-H1) was considered. According to the Hosmer and Lemeshow scale, panel 1 demonstrated an outstanding discriminatory power (AUC 0.903) in predicting LSCC recurrence after PORT. Panel 2 had an excellent discriminatory power too (AUC 0.899).
  
  
  CONCLUSIONS
  Both panels of biomarkers showed an important discriminatory power in pinpointing patients at higher risk of recurrence after PORT for LSCC who could reasonably benefit from adjuvant postoperative chemo-RT.
authors: Department of Neurosciences, Otolaryngology Section, University of Padova, Padova, Italy. Electronic address: gino.marioni@unipd.it.
authors: Gino
authors: G
authors: Marioni
authors: Department of Neurosciences, Otolaryngology Section, University of Padova, Padova, Italy.
authors: Giancarlo
authors: G
authors: Ottaviano
authors: Department of Neurosciences, Otolaryngology Section, University of Padova, Padova, Italy.
authors: Marco
authors: M
authors: Lionello
authors: Department of Neurosciences, Otolaryngology Section, University of Padova, Padova, Italy.
authors: Elena
authors: E
authors: Fasanaro
authors: Department of Neurosciences, Otolaryngology Section Treviso Branch, University of Padova, Treviso, Italy.
authors: Claudia
authors: C
authors: Staffieri
authors: Department of Medicine, DIMED, University of Padova, Padova, Italy.
authors: Luciano
authors: L
authors: Giacomelli
authors: Department of Neurosciences, Otolaryngology Section, University of Padova, Padova, Italy.
authors: Stefano
authors: S
authors: Gattazzo
authors: Department of Neurosciences, Otolaryngology Section, University of Padova, Padova, Italy.
authors: Alberto
authors: A
authors: Staffieri
authors: Department of Medicine, DIMED, University of Padova, Padova, Italy.
authors: Stella
authors: S
authors: Blandamura
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D019583:Dose Fractionation, Radiation; D000071063:Endoglin; D006801:Humans; D007091:Image Processing, Computer-Assisted; D051034:Inhibitor of Apoptosis Proteins / Q000097:blood; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D016015:Logistic Models; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000517:prevention & control; D011379:Prognosis; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000097:blood; D012372:ROC Curve; D018714:Radiotherapy, Adjuvant; D011956:Receptors, Cell Surface / Q000097:blood; D000077022:Survivin; D058570:TOR Serine-Threonine Kinases / Q000097:blood; D016896:Treatment Outcome
chemical_list: D015703:Antigens, CD; C107489:BIRC5 protein, human; D014408:Biomarkers, Tumor; C064206:ENG protein, human; D000071063:Endoglin; D051034:Inhibitor of Apoptosis Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D011956:Receptors, Cell Surface; D000077022:Survivin; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases