title: Huntingtin: here, there, everywhere!
abstract: Huntingtin is the protein mutated in Huntington disease, a dominant inherited neurodegenerative disorder. Huntingtin is ubiquitously expressed throughout the body, however its role outside the central nervous system has been overlooked. This review focuses on the peripheral distribution of huntingtin. It also highlights that huntingtin has central cellular functions, the importance of which may extend beyond the nervous system. Because of the breadth of huntingtin expression and functions, mutant huntingtin undoubtedly causes peripheral disturbances and may be involved in other non neuronal pathologies.
authors: Institut Curie, CNRS UMR 3306, INSERM U1005, Orsay, France.
authors: Cristovao
authors: C
authors: Marques Sousa
authors: Institut Curie, CNRS UMR 3306, INSERM U1005, Orsay, France.
authors: Sandrine
authors: S
authors: Humbert
mesh_terms: D000818:Animals; D006801:Humans; D000071058:Huntingtin Protein; D006816:Huntington Disease / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*
chemical_list: C086055:HTT protein, human; D000071058:Huntingtin Protein; D009419:Nerve Tissue Proteins
keywords: Huntingtin; expression pattern; huntingtin function; peripheral tissues