title: A high-fat diet increases oxidative renal injury and protein glycation in D-galactose-induced aging rats and its prevention by Korea red ginseng.
abstract: Declining renal function is commonly observed with age. Obesity induced by a high-fat diet (HFD) may reduce renal function. Korean red ginseng (KRG) has been reported to ameliorate oxidative tissue injury and have an anti-aging effect. This study was designed to investigate whether HFD would accelerate the D-galactose-induced aging process in the rat kidney and to examine the preventive effect of KRG on HFD and D-galactose-induced aging-related renal injury. When rats with D-galactose-induced aging were fed an HFD for 9 wk, enhanced oxidative DNA damage, renal cell apoptosis, protein glycation, and extracellular high mobility group box 1 protein (HMGB1), a signal of tissue damage, were observed in renal glomerular cells and tubular epithelial cells. However, treatment of rats with HFD- plus D-galactose-induced aging with KRG restored all of these renal changes. Our data suggested that a long-term HFD may enhance D-galactose-induced oxidative renal injury in rats and that this age-related renal injury could be suppressed by KRG through the repression of oxidative injury.
authors: Division of Sports Industry & Science, Mokwon University.
authors: Sok
authors: S
authors: Park
authors: Chan-Sik
authors: CS
authors: Kim
authors: Jinah
authors: J
authors: Min
authors: Soo Hwan
authors: SH
authors: Lee
authors: Yi-Sook
authors: YS
authors: Jung
mesh_terms: D000375:Aging; D000818:Animals; D017209:Apoptosis; D004249:DNA Damage; D059305:Diet, High-Fat / Q000009:adverse effects*; D005690:Galactose / Q000009:adverse effects; D006031:Glycosylation; D024243:HMGB1 Protein / Q000235:genetics / Q000378:metabolism; D007668:Kidney / Q000503:physiopathology; D007674:Kidney Diseases / Q000517:prevention & control*; D008297:Male; D018384:Oxidative Stress; D005894:Panax / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D056910:Republic of Korea
chemical_list: D024243:HMGB1 Protein; C104200:Hbp1 protein, rat; D010936:Plant Extracts; D005690:Galactose