title: Genome-wide analysis of genetic variations assisted by Ingenuity Pathway Analysis to comprehensively investigate potential genetic targets associated with the progression of hepatocellular carcinoma.
abstract: OBJECTIVE
  Hepatocellular carcinoma (HCC) is one of the most common malignant tumors and the third cause of cancer death worldwide. The development of HCC is a multi-pathway regulated process including a variety of genetic mutations and variations.
  
  
  METHODS
  To get an insight into the overall genetic aberration, we analyzed the gene expression profile of 9 HCC samples and 9 normal liver tissues as control. Genes located in these two regions of 4p16.3 and 14q32.1 with gain or loss proceeded to in-depth analysis based on the Ingenuity Pathway Analysis (IPA). Through network analysis of these genes and pathways, molecules highly correlated with HCC and might be targeted for treatments were also hunted out.
  
  
  RESULTS
  Through this method, we found two MicroRNAs (miR-943 and miR-571) that never been reported in HCC samples before.
  
  
  CONCLUSIONS
  Our study has introduced an effective method for cancer research and our work will greatly promote the genetic knowledge of HCC.
authors: Department of Medical Oncology, The People's Hospital of Shaanxi Province, Xi'an, P.R. China. yzhaocai@fmmu.edu.cn.
authors: F
authors: F
authors: Yu
authors: X-Y
authors: XY
authors: Shen
authors: L
authors: L
authors: Fan
authors: Z-C
authors: ZC
authors: Yu
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics*; D055106:Genome-Wide Association Study; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology; D035683:MicroRNAs / Q000235:genetics
chemical_list: D035683:MicroRNAs