title: [Vitamin D and cancer].
abstract: Vitamin D acts through vitamin D receptor, expressed in a variety of human tissues, including cancer tissues of various origins. Basic research has a revealed vitamin D has anti-cancer potentials including pro-differentiation, anti-proliferation, anti-inflammation, anti-angiogenesis and many other effects. Epidemiological studies have revealed that low serum 25 (OH) D level, i.e. vitamin D deficiency/insufficiency, is associated with higher incidence in colon cancer. Low serum 25 (OH) D level in colon or breast cancer patients is associated with poor prognosis. Despite these results, clinical studies so far have not demonstrated any effects of vitamin D supplementation on cancer incidence or prognosis. Many large randomized controlled studies are in-progress now about the effects of vitamin D supplementation on cancer. Their results are anticipated.
authors: Third Department of Medicine, Teikyo University Chiba Medical Center, Japan.
authors: Ryo
authors: R
authors: Okazaki
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D009369:Neoplasms / Q000097:blood* / Q000473:pathology; D011379:Prognosis; D014807:Vitamin D / Q000097:blood / Q000494:pharmacology*
chemical_list: D014807:Vitamin D; D002118:Calcium