title: Role of Riboflavin- and UV Light-Treated Plasma in Prevention of Transfusion-Related Acute Lung Injury.
abstract: BACKGROUND
  Risk reduction strategies for transfusion-related acute lung injury (TRALI) include the preferential use of male donors to provide fresh frozen plasma (FFP). Implementing this measure based on FFP quarantine program is a very complex process. To improve FFP inventory management and the availability of FFP from male donors, the Mirasol Pathogen Reduction Technology(®) (PRT) system for FFP using riboflavin and UV light was adopted in our region in 2012.
  
  
  METHODS
  The percentage of male/female FFP units issued and TRALI cases in patients receiving FFP in the period before implementing riboflavin and UV light (2010-2011) was compared with the period post implementation of riboflavin and UV light (2012-2013).
  
  
  RESULTS
  In 2010 and 2011, there was one FFP transfusion-related TRALI case reported per year, when the proportion of male/female FFP distributed to the hospitals was 60/40. During 2012 and 2013, there have been no FFP transfusion-related TRALI cases, when the proportion of male/female FFP distributed to the hospitals was around 97/3. Mirasol PRT allows quick availability (24 h from collection) compared to quarantined FFP (≥3 months from collection).
  
  
  CONCLUSIONS
  Thanks to its readiness, simplicity and feasibility, riboflavin- and UV light-treated FFP implementation can facilitate the preferential use of FFP from male donors as a TRALI prevention strategy.
authors: Fundació Banc de Sang i Teixits de les Illes Balears, Spain ; Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Palma de Mallorca. Spain.
authors: Teresa
authors: T
authors: Jimenez-Marco
authors: Fundació Banc de Sang i Teixits de les Illes Balears, Spain.
authors: Daniel
authors: D
authors: Ruiz-Alderton
authors: Fundació Banc de Sang i Teixits de les Illes Balears, Spain.
authors: Antonia M
authors: AM
authors: Bautista-Gili
authors: Fundació Banc de Sang i Teixits de les Illes Balears, Spain ; Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Palma de Mallorca. Spain.
authors: Enrique
authors: E
authors: Girona-Llobera
keywords: Plasma; Riboflavin; TRALI; UV light