title: Synthesis of isocoumarins through three-component couplings of arynes, terminal alkynes, and carbon dioxide catalyzed by an NHC-copper complex.
abstract: A copper-catalyzed multicomponent coupling reaction between in situ generated ortho-arynes, terminal alkynes, and carbon dioxide was developed to access isocoumarins in moderate to good yields. The key to this CO2-incorporating reaction was the use of a versatile N-heterocyclic carbene/copper complex that was able to catalyze multiple transformations within the three-component reaction.
authors: Department of Chemistry, School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan).
authors: Woo-Jin
authors: WJ
authors: Yoo
authors: Thanh V Q
authors: TV
authors: Nguyen
authors: Shū
authors: S
authors: Kobayashi
mesh_terms: D000480:Alkynes / Q000737:chemistry; D002245:Carbon Dioxide / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006841:Hydrocarbons, Aromatic / Q000737:chemistry; D049934:Isocoumarins / Q000138:chemical synthesis* / Q000737:chemistry; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*
chemical_list: D000480:Alkynes; D006571:Heterocyclic Compounds; D006841:Hydrocarbons, Aromatic; D049934:Isocoumarins; D009942:Organometallic Compounds; D002245:Carbon Dioxide; C030011:carbene; D003300:Copper; D008697:Methane
keywords: alkynes; arynes; carbon dioxide; copper; multicomponent reactions