title: The cross talk between microbiota and the immune system: metabolites take center stage.
abstract: The human meta-organism consists of more than 90% of microbial cells. The gastrointestinal tract harbors trillions of commensal microorganisms that influence the development and homeostasis of the host. Alterations in composition and function of the microbiota, termed dysbiosis, have been implicated in a multitude of metabolic and inflammatory diseases in humans. Thus, understanding the molecular underpinnings the cross talk between commensal bacteria and their host during homeostasis and dysbiosis may hold the key to understanding many idiopathic diseases. While most attention has focused on the innate recognition of immune-stimulatory bacterial molecules, such as cell wall components and nucleic acids, we emphasize here the impact of diet-dependent microbial metabolites on the development and function of the immune system.
authors: Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
authors: Hagit
authors: H
authors: Shapiro
authors: Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
authors: Christoph A
authors: CA
authors: Thaiss
authors: Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
authors: Maayan
authors: M
authors: Levy
authors: Department of Immunology, Weizmann Institute of Science, Rehovot, Israel. Electronic address: eran.elinav@weizmann.ac.il.
authors: Eran
authors: E
authors: Elinav
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000276:immunology; D005227:Fatty Acids / Q000276:immunology; D006801:Humans; D007107:Immune System; D064307:Microbiota; D011134:Polysaccharides / Q000276:immunology; D014815:Vitamins / Q000276:immunology
chemical_list: D001647:Bile Acids and Salts; D005227:Fatty Acids; D011134:Polysaccharides; D014815:Vitamins