title: Gastro retention using polymer cocoons.
abstract: A gastro-retentive capsule has been prepared which is retained in the stomach for a period of 24h, providing a vehicle for the controlled delivery to the upper intestines. These "gastro cocoons" can resist passage through the sphincter of the stomach, and can retain a high drug payload (30%). They are made from oppositely charged polyelectrolytes and can swell to twice their initial volume. They are strong and also can resist 550 N of compressive force. They are based on filled pharmaceutical capsules which are visible to X-rays. Using ambroxol hydrochloride as a model drug linear, zero-order, release curves were obtained.
authors: AQUA+ TECH Specialties , Geneva , Switzerland.
authors: Julien
authors: J
authors: Arnold
authors: David
authors: D
authors: Hunkeler
mesh_terms: D000178:Acrylamides / Q000737:chemistry*; D000179:Acrylates / Q000737:chemistry*; D000551:Ambroxol / Q000737:chemistry / Q000493:pharmacokinetics; D000818:Animals; D040761:Biomimetic Materials / Q000737:chemistry / Q000494:pharmacology; D002214:Capsules; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000378:metabolism* / Q000493:pharmacokinetics; D004285:Dogs; D004339:Drug Compounding; D004573:Electrolytes / Q000737:chemistry; D005260:Female; D005750:Gastric Juice / Q000737:chemistry; D005753:Gastric Mucosa / Q000378:metabolism*; D005780:Gelatin / Q000737:chemistry; D007700:Kinetics; D011108:Polymers / Q000737:chemistry*; D055672:Static Electricity; D013270:Stomach / Q000187:drug effects
chemical_list: D000178:Acrylamides; D000179:Acrylates; D002214:Capsules; D003692:Delayed-Action Preparations; D004573:Electrolytes; D011108:Polymers; D000551:Ambroxol; D005780:Gelatin; C036658:acrylic acid
keywords: drug-delivery; encapsulation; gastro-retention; polyelectrolyte