title: Plasma clusterin (ApoJ) levels are associated with adiposity and systemic inflammation.
abstract: Obesity and insulin resistance are hallmarks of the metabolic syndrome, which is associated with low-grade chronic inflammation. Clusterin/apolipoprotein J is an abundant plasma chaperone protein that has recently been suggested as a potential biomarker that reflects the inflammatory process in Alzheimer's disease. In the present study, we investigated anthropometric and clinical factors affecting the plasma levels of clusterin in healthy Korean subjects. We measured fasting plasma clusterin levels in healthy Korean adults (111 men and 93 women) using ELISA kit. We analyzed the relationship between plasma clusterin concentrations and anthropometric and clinical parameters. Fasting plasma clusterin concentrations were higher in overweight and obese subjects than in lean subjects. Correlation analysis revealed that the plasma clusterin levels were positively associated with indices of obesity such as body mass index (BMI), waist circumference and waist-hip ratio and markers of systemic inflammation such as high sensitivity C-reactive protein (hsCRP), uric acid, ferritin and retinol binding protein-4. Multiple linear regression analysis showed that sex, BMI and hsCRP were independent determinants of plasma clusterin levels. Furthermore, plasma clusterin levels showed an upward trend with increasing numbers of metabolic syndrome components. These findings suggest that fasting plasma clusterin levels correlate with the parameters of adiposity and systemic inflammation in healthy adults. Therefore, the circulating clusterin level may be a surrogate marker for obesity-associated systemic inflammation.
authors: Department of Internal Medicine, Cardiovascular and Metabolic Disease Center, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.
authors: Jong Chul
authors: JC
authors: Won
authors: Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors: Cheol-Young
authors: CY
authors: Park
authors: Department of Family Medicine, Dongguk University Ilsan Hospital, Ilsan, Korea.
authors: Sang Woo
authors: SW
authors: Oh
authors: Department of Family Medicine, Center for Health Promotion, Ilsan Paik Hospital, Inje University College of Medicine, Ilsan, Korea.
authors: Eon Sook
authors: ES
authors: Lee
authors: Department of Anatomy, School of Medicine, Wonkang University, Iksan, Jeonbuk, Korea.
authors: Byung-Soo
authors: BS
authors: Youn
authors: Department of Internal Medicine, Asan Medical Center University of Ulsan College of Medicine, Seoul, Korea.
authors: Min-Seon
authors: MS
authors: Kim
mesh_terms: D050154:Adiposity; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D051152:Clusterin / Q000097:blood*; D005215:Fasting; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000175:diagnosis; D008875:Middle Aged; D012307:Risk Factors; D012737:Sex Factors; D055815:Young Adult
chemical_list: D051152:Clusterin