title: Management of peripheral neuropathy induced by nab-paclitaxel treatment for breast cancer.
abstract: Nanoparticle albumin-bound paclitaxel (nab-PTX) is a key drug used in breast cancer treatment which often causes chemotherapy-induced peripheral neuropathy (CIPN). No effective approach for CIPN control has been established to date. This study assessed a new approach to CIPN integrating two concepts: compression therapy using stockings and sleeves, and medication therapy using selected prophylactic drugs, including goshajinkigan, which we named the "3S" approach. Fourteen breast cancer patients were divided into a 3S group (n=7) and a control group (n=7), and were treated with 260 mg/m(2) of nab-PTX once every three weeks. CIPN initially developed in five control-group patients and one 3S-group patient (p=0.03). Across all cycles, the CIPN grades, as determined by the Common Terminology Criteria for Adverse Events (CTCAE), were significantly lower in the 3S group than in the control group (p<0.001). The mean nab-PTX dose in the 3S group was 77.1 mg/m(2)/week versus 64.7 mg/m(2)/week in the control group (p<0.01). By controlling the development and severity of CIPN, 3S treatment appears to support the use of the recommended nab-PTX dosing for breast cancer patients.
authors: Department of Surgery, Nagasaki Harbor Medical Center City Hospital, Nagasaki, Japan tysoono@nifty.com.
authors: Tsuyoshi
authors: T
authors: Ohno
authors: Department of Clinical Oncology, Nagasaki Harbor Medical Center City Hospital, Nagasaki, Japan.
authors: Takashi
authors: T
authors: Mine
authors: Department of Pharmacy, Nagasaki Harbor Medical Center City Hospital, Nagasaki, Japan.
authors: Hiroki
authors: H
authors: Yoshioka
authors: Department of Nursing, Nagasaki Harbor Medical Center City Hospital, Nagasaki, Japan.
authors: Mikiko
authors: M
authors: Kosaka
authors: Department of Laboratory Center, Nagasaki Harbor Medical Center City Hospital, Nagasaki, Japan.
authors: Sadayuki
authors: S
authors: Matsuda
authors: Department of International Outpatient, Nagasaki Harbor Medical Center City Hospital, Nagasaki, Japan.
authors: Maiko
authors: M
authors: De Kerckhove
authors: Department of International Outpatient, Nagasaki Harbor Medical Center City Hospital, Nagasaki, Japan.
authors: Charles
authors: C
authors: De Kerckhove
authors: Department of Pathology, Nagasaki Harbor Medical Center City Hospital, Nagasaki, Japan.
authors: Junji
authors: J
authors: Irie
authors: Department of Surgery, Nagasaki Harbor Medical Center City Hospital, Nagasaki, Japan.
authors: Keiji
authors: K
authors: Inoue
authors: Department of Surgery, Nagasaki Harbor Medical Center City Hospital, Nagasaki, Japan.
authors: Masashi
authors: M
authors: Haraguchi
authors: Department of Surgery, Nagasaki Harbor Medical Center City Hospital, Nagasaki, Japan.
authors: Masachika
authors: M
authors: Kitajima
authors: Department of Surgery, Nagasaki Harbor Medical Center City Hospital, Nagasaki, Japan.
authors: Ito
authors: I
authors: Shinichiro
authors: Department of Surgery, Nagasaki Harbor Medical Center City Hospital, Nagasaki, Japan.
authors: Hirotaka
authors: H
authors: Tokai
authors: Department of Surgery, Nagasaki Harbor Medical Center City Hospital, Nagasaki, Japan.
authors: Takayuki
authors: T
authors: Tanaka
authors: Department of Surgery, Nagasaki Harbor Medical Center City Hospital, Nagasaki, Japan.
authors: Ryoko
authors: R
authors: Izumida
mesh_terms: D000328:Adult; D000368:Aged; D000418:Albumins / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D017239:Paclitaxel / Q000009:adverse effects*; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000628:therapy*
chemical_list: C520255:130-nm albumin-bound paclitaxel; D000418:Albumins; D017239:Paclitaxel
keywords: Peripheral neuropathy; compression therapy; goshajinkigan; nab-paclitaxel