title: A cross-sectional study of the relationship between serum liver enzymes level and the incidence of impaired fasting glucose in males and females.
abstract: BACKGROUND
  The aim of this study was to investigate the possible correlation between levels of serum liver enzymes and impaired fasting glucose (IFG) in Chinese adults and to provide a new perspective for the prevention of pre-diabetes.
  
  
  METHODS
  Serum liver enzymes of the samples including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and g-glutamyl transferase (GGT), as well as plasma glucose, blood lipids, and insulin, were measured. The cumulative incidences of IFG between different quartiles of liver enzymes were compared by the chi-square test. A logistic regression model (binary regression) was used to calculate the odds ratio (OR) of IFG with 95% confidence interval (95% CI).
  
  
  RESULTS
  The total incidence of IFG was 20.3% and the cumulative incidence of IFG was higher in men compared to women. In both sexes, IFG is more prevalent in higher quartiles of liver enzymes. After adjusting for age, BMI, blood pressure, triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and total cholesterol (TC), the cumulative incidences of IFG were significantly higher in the highest quartiles of liver enzymes than in the lowest quartiles. A significantly higher cumulative incidence of IFG was found in the highest GGT quartile than in the lowest quartile for woman.
  
  
  CONCLUSIONS
  The results of this study suggest that serum liver enzymes are related to the risk of IFG in Chinese adults. We infer that preserving the hepatic function may be an efficient way to prevent the development of IFG, especially in males.
authors: Department of Laboratory, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China (mainland).
authors: Guangming
authors: G
authors: Qin
authors: Department of Gastroenterology, Xianju People's Hospital, Xianju, China (mainland).
authors: Lihong
authors: L
authors: Lu
authors: Department of Laboratory, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China (mainland).
authors: Yufei
authors: Y
authors: Xiao
authors: Department of Gastroenterology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China (mainland).
authors: Yimiao
authors: Y
authors: Zhu
authors: Department of Gastroenterology, Second Affiliated Hospital Binjiang Campus, School of Medicine, Zhejiang University, Hangzhou, China (mainland).
authors: Wensheng
authors: W
authors: Pan
authors: Department of Pharmacy, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China (mainland).
authors: Xiang
authors: X
authors: Xu
authors: School of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, China (mainland).
authors: Shengrong
authors: S
authors: Shen
authors: UND, Life Sciences, Federal Way, USA.
authors: Undurti N
authors: UN
authors: Das
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D004798:Enzymes / Q000097:blood*; D005260:Female; D006801:Humans; D015994:Incidence; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D008099:Liver / Q000201:enzymology*; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D011236:Prediabetic State / Q000201:enzymology* / Q000453:epidemiology* / Q000517:prevention & control*
chemical_list: D001786:Blood Glucose; D004798:Enzymes; D007328:Insulin; D008055:Lipids; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase