title: Immunopharmacological modulation of mast cells.
abstract: Mast cells produce a wide spectrum of mediators and they have been implicated in several physiopathological conditions (e.g. allergic reactions and certain tumors). Pharmacologic agents that modulate the release of mediators from mast cells has helped to elucidate the biochemical mechanisms by which immunological and non-immunological stimuli activate these cells. Furthermore, the study of surface receptors and signaling pathways associated with mast cell activation revealed novel pharmacologic targets. Thus, the development of pharmacologic agents based on this new wave of knowledge holds promise for the treatment of several mast cell-mediated disorders.
authors: Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, School of Medicine, Via Pansini 5, 80131 Naples, Italy.
authors: Francesco
authors: F
authors: Borriello
authors: Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, School of Medicine, Via Pansini 5, 80131 Naples, Italy.
authors: Francescopaolo
authors: F
authors: Granata
authors: Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, School of Medicine, Via Pansini 5, 80131 Naples, Italy.
authors: Gilda
authors: G
authors: Varricchi
authors: Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, School of Medicine, Via Pansini 5, 80131 Naples, Italy.
authors: Arturo
authors: A
authors: Genovese
authors: Division of Allergy and Clinical Immunology, University of Salerno, School of Medicine, Salerno, Italy.
authors: Massimo
authors: M
authors: Triggiani
authors: Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, School of Medicine, Via Pansini 5, 80131 Naples, Italy. Electronic address: marone@unina.it.
authors: Gianni
authors: G
authors: Marone
mesh_terms: D000818:Animals; D015550:Cell Degranulation / Q000187:drug effects*; D015195:Drug Design; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology*; D008407:Mast Cells / Q000187:drug effects* / Q000276:immunology; D008415:Mastocytosis / Q000188:drug therapy* / Q000276:immunology; D058990:Molecular Targeted Therapy; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D007155:Immunologic Factors