title: One-pot decarboxylative acylation of N-, O-, S-nucleophiles and peptides with 2,2-disubstituted malonic acids.
abstract: Monocarbonyl activation of 2,2-disubstituted malonic acids with benzotriazole leads to decarboxylation of one of the carboxy groups and formation of a CH bond. Intermediate carbonyl benzotriazoles then readily acylate nucleophilic reagents and peptides resulting in libraries of conjugates and peptidomimetics.
authors: Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200 (USA), Fax: (+1) 352-392-9199; Department of Chemistry and Physics, Georgia Regents University, 1120 15th Street SCI W3005, Augusta, GA 30912 (USA). irynal@chem.ufl.edu.
authors: Iryna O
authors: IO
authors: Lebedyeva
authors: Suvendu
authors: S
authors: Biswas
authors: Kevin
authors: K
authors: Goncalves
authors: Sean M
authors: SM
authors: Sileno
authors: Ashton R
authors: AR
authors: Jackson
authors: Kunal
authors: K
authors: Patel
authors: Peter J
authors: PJ
authors: Steel
authors: Alan R
authors: AR
authors: Katritzky
keywords: acylation; cleavage reactions; conjugates; decarboxylation; peptides