title: The dynamics of plant plasma membrane proteins: PINs and beyond.
abstract: Plants are permanently situated in a fixed location and thus are well adapted to sense and respond to environmental stimuli and developmental cues. At the cellular level, several of these responses require delicate adjustments that affect the activity and steady-state levels of plasma membrane proteins. These adjustments involve both vesicular transport to the plasma membrane and protein internalization via endocytic sorting. A substantial part of our current knowledge of plant plasma membrane protein sorting is based on studies of PIN-FORMED (PIN) auxin transport proteins, which are found at distinct plasma membrane domains and have been implicated in directional efflux of the plant hormone auxin. Here, we discuss the mechanisms involved in establishing such polar protein distributions, focusing on PINs and other key plant plasma membrane proteins, and we highlight the pathways that allow for dynamic adjustments in protein distribution and turnover, which together constitute a versatile framework that underlies the remarkable capabilities of plants to adjust growth and development in their ever-changing environment.
authors: Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, Vienna (BOKU), Muthgasse 18, Vienna 1190, Austria christian.luschnig@boku.ac.at gregory.vert@isv.cnrs-gif.fr.
authors: Christian
authors: C
authors: Luschnig
authors: Institut des Sciences du Végétal, CNRS UPR 2355, 1 Avenue de la Terrasse, Bâtiment 23A, Gif-sur-Yvette 91190, France christian.luschnig@boku.ac.at gregory.vert@isv.cnrs-gif.fr.
authors: Grégory
authors: G
authors: Vert
mesh_terms: D017360:Arabidopsis / Q000378:metabolism; D029681:Arabidopsis Proteins / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D002966:Clathrin / Q000378:metabolism; D004705:Endocytosis; D005089:Exocytosis; D018506:Gene Expression Regulation, Plant; D006056:Golgi Apparatus / Q000378:metabolism; D007210:Indoleacetic Acids / Q000378:metabolism; D008024:Ligands; D026901:Membrane Transport Proteins / Q000378:metabolism*; D010937:Plant Growth Regulators / Q000378:metabolism; D010940:Plant Proteins / Q000378:metabolism*; D018517:Plant Roots / Q000378:metabolism; D010944:Plants / Q000378:metabolism; D021381:Protein Transport; D015398:Signal Transduction; D025801:Ubiquitin / Q000378:metabolism
chemical_list: D029681:Arabidopsis Proteins; D002966:Clathrin; D007210:Indoleacetic Acids; D008024:Ligands; D026901:Membrane Transport Proteins; C116363:PIN1 protein, Arabidopsis; D010937:Plant Growth Regulators; D010940:Plant Proteins; D025801:Ubiquitin
keywords: Arabidopsis; PIN protein; Plasma membrane protein; Polarity; Protein sorting