title: Mn-porphyrin conjugated Au nanoshells encapsulating doxorubicin for potential magnetic resonance imaging and light triggered synergistic therapy of cancer.
abstract: A theranostic agent was successfully fabricated by the formation of Au nanoshell around poly(lactic acid) nanoparticles entrapping doxorubicin, followed by linking a Mn-porphyrin derivative on the Au shell surface through polyethylene glycol. The resulted agent exhibited excellent colloidal stability and long blood circulation time due to introducing polyethylene glycol. The grafting Mn-porphyrin onto the nanoparticle surface endowed a greatly improved relaxivity (r1 value of 22.18 mM(-1)s(-1) of Mn(3+)), favorable for accurate cancer diagnosing and locating the tumor site to guide the external near infrared (NIR) laser irradiation for photothermal ablation of tumors. The in vitro experiments confirmed that the agent exhibited an efficient photohyperthermia and a light triggered and stepwise release behavior of doxorubicin due to the high NIR light absorption coefficient of Au nanoshell. The in vivo experiments showed that the combination of chemotherapy and photothermal therapy through such theranostic agent offered a synergistically improved therapeutic outcome compared with either therapy alone, making it a promising approach for cancer therapy. Therefore, such theranostic agent can be developed as a smart and promising nanosystemplatform that integrates multiple capabilities for both effective contrast enhanced magnetic resonance imaging and synergistic therapy.
authors: 1. Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China. ; 2. School of Life Science and Technology. Harbin Institute of Technology, Harbin 150080, China.
authors: Lijia
authors: L
authors: Jing
authors: 1. Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China.
authors: Xiaolong
authors: X
authors: Liang
authors: 2. School of Life Science and Technology. Harbin Institute of Technology, Harbin 150080, China.
authors: Xiaoda
authors: X
authors: Li
authors: 2. School of Life Science and Technology. Harbin Institute of Technology, Harbin 150080, China.
authors: Li
authors: L
authors: Lin
authors: 2. School of Life Science and Technology. Harbin Institute of Technology, Harbin 150080, China.
authors: Yongbo
authors: Y
authors: Yang
authors: 2. School of Life Science and Technology. Harbin Institute of Technology, Harbin 150080, China.
authors: Xueli
authors: X
authors: Yue
authors: 2. School of Life Science and Technology. Harbin Institute of Technology, Harbin 150080, China.
authors: Zhifei
authors: Z
authors: Dai
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000493:pharmacokinetics / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006046:Gold / Q000737:chemistry; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry; D028022:Low-Level Light Therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D008345:Manganese / Q000737:chemistry*; D051379:Mice; D008819:Mice, Nude; D057145:Nanoshells; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D011091:Polyesters; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D011166:Porphyrins / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000903:Antibiotics, Antineoplastic; D011091:Polyesters; D011108:Polymers; D011166:Porphyrins; D019344:Lactic Acid; D011092:Polyethylene Glycols; D008345:Manganese; C033616:poly(lactide); D006046:Gold; D004317:Doxorubicin
keywords: Au nanoshell; chemotherapy; magnetic resonance imaging.; photothermal therapy; porphyrin