title: Integral-geometry characterization of photobiomodulation effects on retinal vessel morphology.
abstract: The morphological characterization of quasi-planar structures represented by gray-scale images is challenging when object identification is sub-optimal due to registration artifacts. We propose two alternative procedures that enhances object identification in the integral-geometry morphological image analysis (MIA) framework. The first variant streamlines the framework by introducing an active contours segmentation process whose time step is recycled as a multi-scale parameter. In the second variant, we used the refined object identification produced in the first variant to perform the standard MIA with exact dilation radius as multi-scale parameter. Using this enhanced MIA we quantify the extent of vaso-obliteration in oxygen-induced retinopathic vascular growth, the preventative effect (by photobiomodulation) of exposure during tissue development to near-infrared light (NIR, 670 nm), and the lack of adverse effects due to exposure to NIR light.
authors: The Eccles Institute of Neuroscience. John Curtin School of Medical Research. The Australian National University, Australia.
authors: Marconi
authors: M
authors: Barbosa
authors: The Eccles Institute of Neuroscience. John Curtin School of Medical Research. The Australian National University, Australia.
authors: Riccardo
authors: R
authors: Natoli
authors: The Eccles Institute of Neuroscience. John Curtin School of Medical Research. The Australian National University, Australia.
authors: Kriztina
authors: K
authors: Valter
authors: The Eccles Institute of Neuroscience. John Curtin School of Medical Research. The Australian National University, Australia.
authors: Jan
authors: J
authors: Provis
authors: The Eccles Institute of Neuroscience. John Curtin School of Medical Research. The Australian National University, Australia.
authors: Ted
authors: T
authors: Maddess
keywords: (100.2960) Image analysis; (170.3880) Medical and biological imaging; (330.5020) Perception psychology