title: Clinical utility of trabectedin for the treatment of ovarian cancer: current evidence.
abstract: Among the pharmaceutical options available for treatment of ovarian cancer, attention has been increasingly focused on trabectedin (ET-743), a drug which displays a unique mechanism of action and has been shown to be active in several human malignancies. Currently, single agent trabectedin is approved for treatment of patients with advanced soft tissue sarcoma after failure of anthracyclines and ifosfamide, and in association with pegylated liposomal doxorubicin for treatment of patients with relapsed partially platinum-sensitive ovarian cancer. This review aims at summarizing the available evidence about the clinical role of trabectedin in the management of patients with epithelial ovarian cancer. Novel perspectives coming from a better understanding of trabectedin mechanisms of action and definition of patients subgroups likely susceptible to benefit of trabectedin treatment are also presented.
authors: Gynecologic Oncology Unit, Department of Oncology, Catholic University of Rome, Italy.
authors: Floriana
authors: F
authors: Mascilini
authors: Gynecologic Oncology Unit, Department of Oncology, Catholic University of Rome, Italy.
authors: Giulia
authors: G
authors: Amadio
authors: Gynecologic Oncology Unit, Department of Oncology, Catholic University of Rome, Italy.
authors: Maria Grazia
authors: MG
authors: Di Stefano
authors: Gynecologic Oncology Unit, Department of Oncology, Catholic University of Rome, Italy.
authors: Manuela
authors: M
authors: Ludovisi
authors: Gynecologic Oncology Unit, Department of Oncology, Catholic University of Rome, Italy.
authors: Alessia
authors: A
authors: Di Legge
authors: Gynecologic Oncology Unit, Department of Oncology, Catholic University of Rome, Italy.
authors: Carmine
authors: C
authors: Conte
authors: Gynecologic Oncology Unit, Department of Oncology, Catholic University of Rome, Italy.
authors: Rosa
authors: R
authors: De Vincenzo
authors: Gynecologic Oncology Unit, Department of Oncology, Catholic University of Rome, Italy.
authors: Caterina
authors: C
authors: Ricci
authors: Gynecologic Oncology Unit, Department of Oncology, Catholic University of Rome, Italy.
authors: Valeria
authors: V
authors: Masciullo
authors: Gynecologic Oncology Unit, Department of Oncology, Catholic University of Rome, Italy.
authors: Vanda
authors: V
authors: Salutari
authors: Gynecologic Oncology Unit, Department of Oncology, Catholic University of Rome, Italy.
authors: Giovanni
authors: G
authors: Scambia
authors: Gynecologic Oncology Unit, Department of Oncology, Catholic University of Rome, Italy.
authors: Gabriella
authors: G
authors: Ferrandina
keywords: ET-743; clinical trials; ovarian cancer