title: The anti-inflammatory effect of cherry blossom extract (Prunus yedoensis) used in soothing skincare product.
abstract: OBJECTIVE
  Previous investigations suggested that cherry blossoms could provide valuable bioactive materials. However, few observations regarding the anti-inflammatory effect of cherry blossoms were reported. This study was to explore the anti-inflammatory effect of cherry blossom extract (CBE), which was used as a soothing ingredient in skincare product.
  
  
  METHODS
  In vitro study, the anti-inflammatory effect of CBE on the nitric oxide (NO) inhibition assay in lipopolysaccharide (LPS)-treated RAW 264.7 cells was investigated. In vivo study, 40 volunteers were included in a randomized, single-blinded, placebo-controlled trial. 24-hour-occlusive test chambers were applied on the flexor side of the forearm with 3% sodium lauryl sulphate (SLS). Subsequently, the test areas were treated on 9 subsequent days with a cream containing 3% CBE or a placebo. Evaluation included a visual score and determination of erythema value (E value).
  
  
  RESULTS
  In vitro study, 2% CBE reduced NO production by 31.83% compared to the placebo. In the SLS irritant patch test, the visual score and erythema value of CBE were lower than that of the placebo on D5 and D9.
  
  
  CONCLUSIONS
  Cherry blossom extract shows good anti-inflammatory effect in vitro and in vivo and represents a promising functional ingredient in soothing skincare product by reducing skin inflammation.
authors: Department of Dermatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.
authors: Y Q
authors: YQ
authors: Zhang
authors: L
authors: L
authors: Guan
authors: Z Y
authors: ZY
authors: Zhong
authors: M
authors: M
authors: Chang
authors: D K
authors: DK
authors: Zhang
authors: H
authors: H
authors: Li
authors: W
authors: W
authors: Lai
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002460:Cell Line; D005260:Female; D035264:Flowers / Q000737:chemistry; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D008264:Macrophages / Q000187:drug effects; D008297:Male; D051379:Mice; D008875:Middle Aged; D009573:Nitrites / Q000032:analysis; D010328:Patch Tests; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D027861:Prunus / Q000737:chemistry*; D017592:Skin Care / Q000379:methods*; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D009573:Nitrites; D010936:Plant Extracts
keywords: anti-inflammatory effect; cherry blossom extract; cosmetic