title: The regulatory role of activating transcription factor 2 in inflammation.
abstract: Activating transcription factor 2 (ATF2) is a member of the leucine zipper family of DNA-binding proteins and is widely distributed in tissues including the liver, lung, spleen, and kidney. Like c-Jun and c-Fos, ATF2 responds to stress-related stimuli and may thereby influence cell proliferation, inflammation, apoptosis, oncogenesis, neurological development and function, and skeletal remodeling. Recent studies clarify the regulatory role of ATF2 in inflammation and describe potential inhibitors of this protein. In this paper, we summarize the properties and functions of ATF2 and explore potential applications of ATF2 inhibitors as tools for research and for the development of immunosuppressive and anti-inflammatory drugs.
authors: Linyi Center for Disease Control and Prevention, Linyi 276000, China ; Department of Genetic Engineering, Sungkyunkwan University, Suwon 440-746, Republic of Korea.
authors: Tao
authors: T
authors: Yu
authors: Linyi Center for Disease Control and Prevention, Linyi 276000, China.
authors: Yong Jun
authors: YJ
authors: Li
authors: Laiwu Center for Disease Control and Prevention, Laiwu 271100, China.
authors: Ai Hong
authors: AH
authors: Bian
authors: Linyi Center for Disease Control and Prevention, Linyi 276000, China.
authors: Hui Bin
authors: HB
authors: Zuo
authors: Linyi Center for Disease Control and Prevention, Linyi 276000, China.
authors: Ti Wen
authors: TW
authors: Zhu
authors: Linyi Center for Disease Control and Prevention, Linyi 276000, China.
authors: Sheng Xiang
authors: SX
authors: Ji
authors: Linyi Center for Disease Control and Prevention, Linyi 276000, China.
authors: Fanming
authors: F
authors: Kong
authors: Linyi Center for Disease Control and Prevention, Linyi 276000, China.
authors: De Qing
authors: DQ
authors: Yin
authors: Linyi Center for Disease Control and Prevention, Linyi 276000, China.
authors: Chuan Bao
authors: CB
authors: Wang
authors: Linyi Center for Disease Control and Prevention, Linyi 276000, China.
authors: Zi Fu
authors: ZF
authors: Wang
authors: Linyi Center for Disease Control and Prevention, Linyi 276000, China.
authors: Hong Qun
authors: HQ
authors: Wang
authors: Department of Genetic Engineering, Sungkyunkwan University, Suwon 440-746, Republic of Korea.
authors: Yanyan
authors: Y
authors: Yang
authors: Research Institute and Hospital, National Cancer Center, Goyang 410-769, Republic of Korea.
authors: Byong Chul
authors: BC
authors: Yoo
authors: Department of Genetic Engineering, Sungkyunkwan University, Suwon 440-746, Republic of Korea.
authors: Jae Youl
authors: 0000-0001-8141-9927
authors: JY
authors: Cho
mesh_terms: D051698:Activating Transcription Factor 2 / Q000378:metabolism*; D017209:Apoptosis / Q000502:physiology; D049109:Cell Proliferation / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000378:metabolism*
chemical_list: C497105:ATF2 protein, human; D051698:Activating Transcription Factor 2