title: Occupational brain cancer risks in Umbria (Italy), with a particular focus on steel foundry workers.
abstract: OBJECTIVE
  As a part of the Occupational Cancer Monitoring (OCCAM) project, a routine analysis based on Umbria region cancer registry (RTUP) database in 2002-2008 was performed. Among other results, the incidental finding of brain cancer increased risk in steel foundry workers in Terni province (Italy), lead us to deepen the analysis, focusing on this specific industrial sector.
  
  
  METHODS
  A monitoring study, based on Umbria Regional Cancer Registry data, was recently carried out. Brain cancer cases and controls identified within this preliminary study were selected. Therefore, we considered all incident cases (in Umbria region 2002-2008) of brain cancer occurred among workers occupied for at least one year in private companies since 1974 and controls randomly sampled from the same population. Afterwards, taking in to account results from steel foundry in Terni province, we further deepened our analysis, focusing on this productive sector. Odds ratios (ORs) and corresponding 90% confidence intervals (CIs) were calculated using multiple logistic regression models, adjusted by age at diagnosis or sampling, sex and province of residence, when appropriate.
  
  
  RESULTS
  Statistical analyses were carried out on 14913 subjects, 56 cases and 14857 controls. Significantly increased ORs were observed for garment, mechanical manufacturing and chemical industries. Moreover, the risk estimates were strongly correlated with exposures in iron and steel foundries and a cluster of 14 cases in the same foundry in Terni was observed (OR 9.59, 90% CI 2.76-33.34).
  
  
  CONCLUSIONS
  Results of this explorative study showed increased ORs of brain cancer in some productive branches, involving possible exposures to chemical compounds and/or solvents. Moreover, our results pointed out a significantly increased risk in Terni foundry workers, determining an interesting brain cancer cluster (14 cases). Further studies on this industrial sector are needed with improved definitions of tasks and exposures.
authors: Enrico
authors: E
authors: Oddone
authors: Alessandra
authors: A
authors: Scaburri
authors: Edoardo
authors: E
authors: Bai
authors: Carlo
authors: C
authors: Modonesi
authors: Fabrizio
authors: F
authors: Stracci
authors: Giuliano
authors: G
authors: Marchionna
authors: Paolo
authors: P
authors: Crosignani
authors: Marcello
authors: M
authors: Imbriani
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000453:epidemiology* / Q000209:etiology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D015994:Incidence; D007221:Industry; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000453:epidemiology* / Q000209:etiology*; D016273:Occupational Exposure / Q000009:adverse effects*; D012042:Registries; D018570:Risk Assessment; D012307:Risk Factors; D013232:Steel
chemical_list: D013232:Steel