title: Xenortide Biosynthesis by Entomopathogenic Xenorhabdus nematophila.
abstract: The biosynthesis gene cluster of the xenortides and a new derivative, xenortide D, which is produced in only trace amounts, was identified in Xenorhabdus nematophila. The structure of xenortide D was elucidated using a combination of labeling experiments followed by MS analysis and was confirmed by synthesis. Bioactivity tests revealed a weak activity of tryptamine-carrying xenortides against Plasmodium falciparum and Trypanosoma brucei.
authors: Merck Stiftungsprofessur für Molekulare Biotechnologie, Fachbereich Biowissenschaften, Goethe Universität Frankfurt , 60438 Frankfurt am Main, Germany.
authors: Daniela
authors: D
authors: Reimer
authors: Merck Stiftungsprofessur für Molekulare Biotechnologie, Fachbereich Biowissenschaften, Goethe Universität Frankfurt , 60438 Frankfurt am Main, Germany.
authors: Friederike I
authors: FI
authors: Nollmann
authors: Merck Stiftungsprofessur für Molekulare Biotechnologie, Fachbereich Biowissenschaften, Goethe Universität Frankfurt , 60438 Frankfurt am Main, Germany.
authors: Katharina
authors: K
authors: Schultz
authors: Swiss Tropical and Public Health Institute , Parasite Chemotherapy Socinstraße 57, P.O. Box, CH-4002 Basel, Switzerland.
authors: Marcel
authors: M
authors: Kaiser
authors: Merck Stiftungsprofessur für Molekulare Biotechnologie, Fachbereich Biowissenschaften, Goethe Universität Frankfurt , 60438 Frankfurt am Main, Germany.
authors: Helge B
authors: HB
authors: Bode
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004151:Dipeptides / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D007891:Leishmania / Q000187:drug effects; D015394:Molecular Structure; D005810:Multigene Family; D019906:Nuclear Magnetic Resonance, Biomolecular; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects; D014346:Trypanosoma brucei brucei / Q000187:drug effects; D014363:Tryptamines / Q000737:chemistry; D020593:Xenorhabdus / Q000737:chemistry*
chemical_list: D004151:Dipeptides; D014363:Tryptamines; C000601917:xenortide D