title: Protective effects of testosterone propionate on reproductive toxicity caused by Endosulfan in male mice.
abstract: To investigate the protective effect of testosterone propionate (TP) on reproductive toxicity caused by endosulfan in male mice, three group experiments were designed: the control group received 0 and 0, the endosulfan group received 0.8 and 0, and the endosulfan + TP group received 0.8 mg/kg/d endosulfan and 10 mg/kg/d TP, respectively. The results showed that TP significantly prevented the declines of concentration and motility rates in sperm, reduced the rate of sperm abnormalities in epididymis; and antagonized the decreases in spermatogenous cell and sperm numbers in testes induced by endosulfan. TP also decreased the numbers of cavities formed, prevented the decreases of plasma testosterone and androgen receptor (AR) mRNA in testicular tissue, alleviated the increase of LH induced by endosulfan. It is likely that TP relieve the reproductive toxicity by reversing the endosulfan-induced decreases in testosterone secretion and AR expression that resulted from the alteration of Leydig cell function.
authors: Department of Toxicology and Hygienic Chemistry, School of Public Health, Capital Medical University, Beijing, 100069, China.|Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, China.|Department of Laboratory Animal Science, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
authors: Na
authors: N
authors: Wang
authors: Department of Toxicology and Hygienic Chemistry, School of Public Health, Capital Medical University, Beijing, 100069, China.|Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, China.
authors: Ying
authors: Y
authors: Xu
authors: Department of Toxicology and Hygienic Chemistry, School of Public Health, Capital Medical University, Beijing, 100069, China.|Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, China.
authors: Xian-Qing
authors: XQ
authors: Zhou
authors: Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
authors: Yan-Hua
authors: YH
authors: Wu
authors: Department of Laboratory Animal Science, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
authors: Sheng-Li
authors: SL
authors: Li
authors: Department of Laboratory Animal Science, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
authors: Xin
authors: X
authors: Qiao
authors: Department of Toxicology and Hygienic Chemistry, School of Public Health, Capital Medical University, Beijing, 100069, China.|Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, China.
authors: Yan-Bo
authors: YB
authors: Li
authors: Department of Toxicology and Hygienic Chemistry, School of Public Health, Capital Medical University, Beijing, 100069, China.|Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, China.
authors: Zhi-Wei
authors: ZW
authors: Sun
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D004726:Endosulfan / Q000633:toxicity*; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D007248:Infertility, Male / Q000139:chemically induced* / Q000517:prevention & control*; D007306:Insecticides / Q000633:toxicity*; D007985:Leydig Cells / Q000187:drug effects; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D011944:Receptors, Androgen / Q000187:drug effects; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects; D013737:Testis / Q000166:cytology / Q000187:drug effects; D043343:Testosterone Propionate / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D007306:Insecticides; D012333:RNA, Messenger; D011944:Receptors, Androgen; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D004726:Endosulfan; D043343:Testosterone Propionate
keywords: androgen receptor; endosulfan; energy metabolism; oxidative damage; reproductive toxicity; testosterone propionate