title: Toxicology and the chemical foundation of plants of Erycibe.
abstract: Erycibe is a relatively small genus in the family Convolvulaceae with over 10 identified species. Some Erycibe plant species are purportedly toxic at high doses. However, few toxicology studies have been conducted on those species. In this study, the toxicity of 40% ethanolic extracts of Erycibeobtusifolia, Erycibeschmidtii, and Erycibeellipptimba was evaluated. E. ellipptimba has been reported to be more toxic due to containing larger amounts of Baogongteng C, an alkaloid with known toxicity. Thus, E. ellipptimba was chosen for further toxicology study here. An HPLC-MS method was developed to identify the main components and determine the percentages of Baogongteng C in total alkaloid of E. ellipptimba (EWA). The toxicity of total alkaloid and Baogongteng C was evaluated and compared. The results indicated that Baogongteng A and Baogongteng C are the major toxic chemical compounds of the Erycibe species tested. The results also suggest EWA is cholinergic. Finally, in a subacute toxicity study of EWA, alterations observed with high dosage suggest that the liver and kidney could be the target organs of toxicity.
authors: Department of Pharmacognosy, China Pharmaceutical University, Nanjing 210038, People's Republic of China. Electronic address: chenzhiyong0612@sina.com.
authors: Zhiyong
authors: Z
authors: Chen
authors: Department of Pharmacognosy, China Pharmaceutical University, Nanjing 210038, People's Republic of China; The MOE Key Laboratory for Standardization of Chinese Medicines and The Shanghai Key Laboratory for Compound Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201210, People's Republic of China.
authors: Li
authors: L
authors: Wang
authors: The MOE Key Laboratory for Standardization of Chinese Medicines and The Shanghai Key Laboratory for Compound Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201210, People's Republic of China.
authors: Liping
authors: L
authors: Liao
authors: The MOE Key Laboratory for Standardization of Chinese Medicines and The Shanghai Key Laboratory for Compound Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201210, People's Republic of China; Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai 201210, People's Republic of China. Electronic address: 18721608946@163.com.
authors: Zijia
authors: Z
authors: Zhang
authors: Department of Pharmacognosy, China Pharmaceutical University, Nanjing 210038, People's Republic of China; The MOE Key Laboratory for Standardization of Chinese Medicines and The Shanghai Key Laboratory for Compound Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201210, People's Republic of China; Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai 201210, People's Republic of China. Electronic address: wangzht@hotmail.com.
authors: Zhengtao
authors: Z
authors: Wang
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification / Q000633:toxicity; D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D027722:Convolvulaceae / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D013058:Mass Spectrometry / Q000379:methods; D051379:Mice; D008813:Mice, Inbred ICR; D010936:Plant Extracts / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013045:Species Specificity; D014326:Tropanes / Q000302:isolation & purification / Q000633:toxicity*
chemical_list: D000470:Alkaloids; D010936:Plant Extracts; D014326:Tropanes; C417573:baogongteng C; C027863:bao gong teng A
keywords: Acute toxicity; Baogongteng A; Baogongteng C; Erycibe; Erycibe ellipptimba; Erycibe obtusifolia; Erycibe schmidtii; Subacute toxicity