title: Development of U11-functionalized gold nanoparticles for selective targeting of urokinase plasminogen activator receptor-positive breast cancer cells.
abstract: The functionalization of colloidal nanoparticles with short peptides often fails in achieving satisfactory targeting efficiency and selectivity toward receptor-specific human cells. Here, we show that an optimized passivation of gold nanoparticle surface with a mixed self-assembled monolayer, including a targeting ligand, a fluorescent dye, and an intercalating short PEG derivative, led to a very stable, nontoxic, and efficient nanoconjugate for targeting urokinase plasminogen activator receptor-positive breast cancer cells.
authors: NanoBioLab, Dipartimento di Biotecnologie e Bioscienze, Università di Milano-Bicocca , Piazza della Scienza 2, 20126 Milano, Italy.
authors: Svetlana
authors: S
authors: Avvakumova
authors: Elisabetta
authors: E
authors: Galbiati
authors: Laura
authors: L
authors: Pandolfi
authors: Serena
authors: S
authors: Mazzucchelli
authors: Marco
authors: M
authors: Cassani
authors: Alessandro
authors: A
authors: Gori
authors: Renato
authors: R
authors: Longhi
authors: Davide
authors: D
authors: Prosperi
mesh_terms: D000595:Amino Acid Sequence; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology*; D045744:Cell Line, Tumor; D015195:Drug Design; D005456:Fluorescent Dyes / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D006801:Humans; D008024:Ligands; D053768:Metal Nanoparticles / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D058990:Molecular Targeted Therapy; D009842:Oligopeptides / Q000737:chemistry* / Q000378:metabolism*; D011092:Polyethylene Glycols / Q000737:chemistry; D055293:Receptors, Urokinase Plasminogen Activator / Q000378:metabolism*; D013379:Substrate Specificity
chemical_list: D005456:Fluorescent Dyes; D008024:Ligands; D009842:Oligopeptides; D055293:Receptors, Urokinase Plasminogen Activator; D011092:Polyethylene Glycols; D006046:Gold