title: Serum lipid profile and its association with hypertension in Bangladesh.
abstract: BACKGROUND
  Hypertension and dyslipidemia are major risk factors for cardiovascular disease, accounting for the highest morbidity and mortality among the Bangladeshi population. The objective of this study was to determine the association between serum lipid profiles in hypertensive patients with normotensive control subjects in Bangladesh.
  
  
  METHODS
  A cross-sectional study was carried out among 234 participants including 159 hypertensive patients and 75 normotensive controls from January to December 2012 in the National Centre for Control of Rheumatic Fever and Heart Disease in Dhaka, Bangladesh. Data were collected on sociodemographic factors, anthropometric measurements, blood pressure, and lipid profile including total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), and high density lipoprotein (HDL).
  
  
  RESULTS
  The mean (± standard deviation) systolic blood pressure and diastolic blood pressure of the participants were 137.94±9.58 and 94.42±8.81, respectively, which were higher in the hypertensive patients (P<0.001). The serum levels of TC, TG, and LDL were higher while HDL levels were lower in hypertensive subjects compared to normotensives, which was statistically significant (P<0.001). Age, waist circumference, and body mass index showed significant association with hypertensive patients (P<0.001) but not with normotensives. The logistic regression analysis showed that hypertensive patients had 1.1 times higher TC and TG, 1.2 times higher LDL, and 1.1 times lower HDL than normotensives, which was statistically significant (P<0.05).
  
  
  CONCLUSIONS
  Hypertensive patients in Bangladesh have a close association with dyslipidemia and need measurement of blood pressure and lipid profile at regular intervals to prevent cardiovascular disease, stroke, and other comorbidities.
authors: Department of Epidemiology, National Centre for Control of Rheumatic Fever and Heart Disease, Bangladesh, Dhaka, Bangladesh.
authors: Kamrun Nahar
authors: KN
authors: Choudhury
authors: Center for Communicable Diseases, International Center for Diarrheal Disease Research, Bangladesh, Dhaka, Bangladesh.
authors: A K M
authors: AK
authors: Mainuddin
authors: Department of Cardiology, Bangladesh Institute of Health Science, Bangladesh, Dhaka, Bangladesh.
authors: Mohammad
authors: M
authors: Wahiduzzaman
authors: Center for Control of Chronic Diseases, International Center for Diarrheal Disease Research, Bangladesh, Dhaka, Bangladesh ; Center for International Health, University of Munich, Munich, Germany.
authors: Sheikh Mohammed Shariful
authors: SM
authors: Islam
mesh_terms: D000328:Adult; D001459:Bangladesh / Q000453:epidemiology; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000453:epidemiology*; D008055:Lipids / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013997:Time Factors
chemical_list: D015415:Biomarkers; D008055:Lipids
keywords: Risk factors; blood pressure; cardiovascular diseases; dyslipidemia