title: Acetic acid promoted metal-free aerobic carbon-carbon bond forming reactions at α-position of tertiary amines.
abstract: The oxidative functionalization of the benzylic C-H bonds in tetrahydroisoquinolines and tetrahydro-β-carboline derivatives was investigated. C-C bond forming reactions proceeded with a range of nucleophiles (nitroalkane, enol silyl ether, indole, allylstannane, and tetrabutylammonium cyanide) under metal-free conditions and an oxygen atmosphere. Acetic acid caused a significant acceleration effect.
authors: Graduate School of Pharmaceutical Sciences, Tohoku University , Aoba 6-3, Aramaki, Aoba-ku, Sendai 980-8578, Japan.
authors: Hirofumi
authors: H
authors: Ueda
authors: Kei
authors: K
authors: Yoshida
authors: Hidetoshi
authors: H
authors: Tokuyama
mesh_terms: D019342:Acetic Acid / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D044005:Tetrahydroisoquinolines / Q000737:chemistry
chemical_list: D000588:Amines; D044005:Tetrahydroisoquinolines; D002244:Carbon; D019342:Acetic Acid