title: Pharmacokinetic and safety profiles of repeated-dose prophylactic micafungin in children and adolescents undergoing hematopoietic stem cell transplantation.
abstract: Micafungin is a potent echinocandin antifungal that can be used for both prophylaxis and treatment of Candida infections. This open-label study assessed the pharmacokinetics and safety profile of prophylactic micafungin in children and adolescents (aged 4 mo to 16 y) undergoing hematopoietic stem cell transplantation. Patients received once-daily doses of either 1 or 1.5 mg/kg micafungin, based on their body weight, for 10 to 14 days. In total, 40 patients received micafungin. Area under the plasma micafungin concentration-time curve was highest in patients aged 6 to 11 years in the 1.5 mg/kg treatment group. Peak plasma micafungin concentration displayed no age-related differences, but was higher in the 1.5 mg/kg versus the 1 mg/kg group. Clearance at steady state by weight and volume of distribution by weight were considerably higher in patients aged 4 months to 5 years. Results from this study show that age and body weight affect micafungin pharmacokinetics in pediatric patients undergoing hematopoietic stem cell transplantation.
authors: *Department of Pediatrics, School of Medicine and Children's Hospital Colorado, University of Colorado, Aurora, CO †Astellas Pharma Global Development, Northbrook, IL ‡Division of Infectious Disease, Children's Hospital of Orange County, Orange, CA.
authors: Edythe
authors: E
authors: Albano
authors: Nkechi
authors: N
authors: Azie
authors: Mike
authors: M
authors: Roy
authors: Robert
authors: R
authors: Townsend
authors: Antonio
authors: A
authors: Arrieta
mesh_terms: D000293:Adolescent; D000935:Antifungal Agents / Q000493:pharmacokinetics*; D002648:Child; D002675:Child, Preschool; D054714:Echinocandins / Q000009:adverse effects / Q000493:pharmacokinetics*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D055666:Lipopeptides / Q000009:adverse effects / Q000493:pharmacokinetics*; D008297:Male; D000077551:Micafungin; D009181:Mycoses / Q000517:prevention & control*
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077551:Micafungin