title: Exploring iris colour prediction and ancestry inference in admixed populations of South America.
abstract: New DNA-based predictive tests for physical characteristics and inference of ancestry are highly informative tools that are being increasingly used in forensic genetic analysis. Two eye colour prediction models: a Bayesian classifier - Snipper and a multinomial logistic regression (MLR) system for the Irisplex assay, have been described for the analysis of unadmixed European populations. Since multiple SNPs in combination contribute in varying degrees to eye colour predictability in Europeans, it is likely that these predictive tests will perform in different ways amongst admixed populations that have European co-ancestry, compared to unadmixed Europeans. In this study we examined 99 individuals from two admixed South American populations comparing eye colour versus ancestry in order to reveal a direct correlation of light eye colour phenotypes with European co-ancestry in admixed individuals. Additionally, eye colour prediction following six prediction models, using varying numbers of SNPs and based on Snipper and MLR, were applied to the study populations. Furthermore, patterns of eye colour prediction have been inferred for a set of publicly available admixed and globally distributed populations from the HGDP-CEPH panel and 1000 Genomes databases with a special emphasis on admixed American populations similar to those of the study samples.
authors: Unidad de Genética Forense, Instituto de Ciencias Forenses Luis Concheiro, Grupo de Medicina Xenómica, Universidade de Santiago de Compostela, Spain.
authors: A
authors: A
authors: Freire-Aradas
authors: Unidad de Genética Forense, Instituto de Ciencias Forenses Luis Concheiro, Grupo de Medicina Xenómica, Universidade de Santiago de Compostela, Spain.
authors: Y
authors: Y
authors: Ruiz
authors: Unidad de Genética Forense, Instituto de Ciencias Forenses Luis Concheiro, Grupo de Medicina Xenómica, Universidade de Santiago de Compostela, Spain. Electronic address: c.phillips@mac.com.
authors: C
authors: C
authors: Phillips
authors: Unidad de Genética Forense, Instituto de Ciencias Forenses Luis Concheiro, Grupo de Medicina Xenómica, Universidade de Santiago de Compostela, Spain.
authors: O
authors: O
authors: Maroñas
authors: Unidad de Genética Forense, Instituto de Ciencias Forenses Luis Concheiro, Grupo de Medicina Xenómica, Universidade de Santiago de Compostela, Spain.
authors: J
authors: J
authors: Söchtig
authors: Facultade de Matemáticas, Universidade de Santiago de Compostela, Spain.
authors: A Gómez
authors: AG
authors: Tato
authors: Facultade de Matemáticas, Universidade de Santiago de Compostela, Spain.
authors: J Álvarez
authors: JÁ
authors: Dios
authors: Facultade de Matemáticas, Universidade de Santiago de Compostela, Spain.
authors: M Casares
authors: MC
authors: de Cal
authors: Faculdade de Farmácia, Universidade Federal do Río Grande do Norte, Natal, Brazil.
authors: V N
authors: VN
authors: Silbiger
authors: Faculdade de Farmácia, Universidade Federal do Río Grande do Norte, Natal, Brazil.
authors: A D
authors: AD
authors: Luchessi
authors: Faculdade de Ciências Aplicadas, Universidade Estadual de Campinas, Limeira, Brazil.
authors: A D
authors: AD
authors: Luchessi
authors: University Centro-Occidental Lisandro Alvarado, Barquisimeto, Venezuela.
authors: M A
authors: MA
authors: Chiurillo
authors: Unidad de Genética Forense, Instituto de Ciencias Forenses Luis Concheiro, Grupo de Medicina Xenómica, Universidade de Santiago de Compostela, Spain; Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.
authors: Á
authors: Á
authors: Carracedo
authors: Unidad de Genética Forense, Instituto de Ciencias Forenses Luis Concheiro, Grupo de Medicina Xenómica, Universidade de Santiago de Compostela, Spain.
authors: M V
authors: MV
authors: Lareu
mesh_terms: D001938:Brazil; D004247:DNA / Q000235:genetics; D005006:Ethnicity / Q000235:genetics*; D005127:Eye Color / Q000235:genetics*; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D016013:Likelihood Functions; D016015:Logistic Models; D020641:Polymorphism, Single Nucleotide; D044469:Racial Groups / Q000235:genetics*; D012680:Sensitivity and Specificity; D014687:Venezuela
chemical_list: D004247:DNA
keywords: Admixture; America; Genetic ancestry; Iris colour prediction; SNPs