title: Proposed ratios and cutoffs for the assessment of lipodystrophy in HIV-seropositive individuals.
abstract: OBJECTIVE
  To propose objective ratios using anthropometry and dual-energy X-ray absorptiometry (DXA) and to suggest cutoff points for them in order to classify lipodystrophy in male patients.
  
  
  METHODS
  It is a cross-sectional study. DXA was applied and anthropometric measurements were performed in 100 men on highly active antiretroviral therapy. Receiver operating characteristic curves were used to propose cutoffs. Individuals were divided in without (lipo-) or with (lipo+) lipodystrophy and their metabolic parameters were compared.
  
  
  RESULTS
  The following ratios were proposed: fat mass ratio by DXA (FMR), waist thigh ratio (WTR), waist calf ratio (WCR), and arm to trunk ratio (ATR). The best cutoffs observed for FMR, WTR and ATR were 1.26, 1.74 and 2.08, respectively. Using the proposed cutoff for FMR, we observed worse metabolic profile, with increased tryglicerides, fasting serum glucose and more hypercholesterolemia in the lipo+ group. WTR and ATR showed a significant correlation with FMR.
  
  
  CONCLUSIONS
  Anthropometric ratios (WTR/ATR) and FMR can be used to aid the diagnosis of lipodystrophy in order to contribute to a more accurate and earlier diagnosis permitting intervention and even preventing metabolic disturbances.
authors: Department of Internal Medicine, Ribeirao Preto Medical School, University of São Paulo, Ribeirao Preto, Brazil.
authors: R A
authors: RA
authors: Beraldo
authors: Health Promotion Program, University of Franca, Franca, Brazil.
authors: H S
authors: HS
authors: Vassimon
authors: Department of Pediatrics, Ribeirao Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
authors: D C
authors: DC
authors: Aragon
authors: Department of Internal Medicine, Ribeirao Preto Medical School, University of São Paulo, Ribeirao Preto, Brazil.
authors: A M
authors: AM
authors: Navarro
authors: Department of Internal Medicine, Ribeirao Preto Medical School, University of São Paulo, Ribeirao Preto, Brazil.
authors: F J
authors: FJ
authors: Albuquerque de Paula
authors: Department of Internal Medicine, Ribeirao Preto Medical School, University of São Paulo, Ribeirao Preto, Brazil.
authors: M C
authors: MC
authors: Foss-Freitas
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods; D000273:Adipose Tissue; D000328:Adult; D000886:Anthropometry / Q000379:methods; D023241:Antiretroviral Therapy, Highly Active; D001786:Blood Glucose / Q000378:metabolism; D001823:Body Composition; D001837:Body Weights and Measures; D003430:Cross-Sectional Studies; D015658:HIV Infections / Q000150:complications; D006679:HIV Seropositivity / Q000150:complications*; D039682:HIV-Associated Lipodystrophy Syndrome / Q000175:diagnosis*; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications / Q000453:epidemiology; D007333:Insulin Resistance; D050356:Lipid Metabolism; D008060:Lipodystrophy / Q000175:diagnosis / Q000209:etiology; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012016:Reference Values; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D014280:Triglycerides