title: Challenges for nerve repair using chitosan-siloxane hybrid porous scaffolds.
abstract: The treatment of peripheral nerve injuries remains one of the greatest challenges of neurosurgery, as functional recover is rarely satisfactory in these patients. Recently, biodegradable nerve guides have shown great potential for enhancing nerve regeneration. A major advantage of these nerve guides is that no foreign material remains after the device has fulfilled its task, which spares a second surgical intervention. Recently, we studied peripheral nerve regeneration using chitosan-γ-glycidoxypropyltrimethoxysilane (chitosan-GPTMS) porous hybrid membranes. In our studies, these porous membranes significantly improved nerve fiber regeneration and functional recovery in rat models of axonotmetic and neurotmetic sciatic nerve injuries. In particular, the number of regenerated myelinated nerve fibers and myelin thickness were significantly higher in rat treated with chitosan porous hybrid membranes, whether or not they were used in combination with mesenchymal stem cells isolated from the Wharton's jelly of the umbilical cord. In this review, we describe our findings on the use of chitosan-GPTMS hybrids for nerve regeneration.
authors: Frontier Research Academy for Young Researchers, Kyushu Institute of Technology, 2-4 Hibikino, Wakamatsu-ku, Kitakyushu 808-0196, Japan.
authors: Yuki
authors: Y
authors: Shirosaki
authors: Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan.
authors: Satoshi
authors: S
authors: Hayakawa
authors: Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan.
authors: Akiyoshi
authors: A
authors: Osaka
authors: CEMUC, Departamento de Engenharia Metalúrgica e Materiais, Universidade do Porto, 4200-465 Porto, Portugal.
authors: Maria A
authors: MA
authors: Lopes
authors: CEMUC, Departamento de Engenharia Metalúrgica e Materiais, Universidade do Porto, 4200-465 Porto, Portugal.
authors: José D
authors: JD
authors: Santos
authors: Neuroscience Institute of the Cavalieri Ottolenghi Foundation, University of Turin, Regione Gonzole 10, 10043 Orbassano, Italy ; Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, 10043 Orbassano, Italy.
authors: Stefano
authors: S
authors: Geuna
authors: Departamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira No. 228, 4050-313 Porto, Portugal ; Centro de Estudos de Ciência Animal (CECA), Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares (ICETA), Rua D. Manuel II, Apartado 55142, 4051-401 Porto, Portugal.
authors: Ana C
authors: AC
authors: Mauricio
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D004195:Disease Models, Animal; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology; D009186:Myelin Sheath / Q000737:chemistry; D009413:Nerve Fibers, Myelinated / Q000378:metabolism; D009416:Nerve Regeneration; D019636:Neurodegenerative Diseases / Q000628:therapy; D016062:Porosity; D051381:Rats; D012584:Sciatic Nerve / Q000473:pathology; D012821:Silanes / Q000737:chemistry; D012833:Siloxanes / Q000737:chemistry*; D054457:Tissue Scaffolds / Q000737:chemistry*; D014470:Umbilical Cord / Q000166:cytology
chemical_list: C403136:3-glycidoxypropyltrimethoxysilane; D001672:Biocompatible Materials; D012821:Silanes; D012833:Siloxanes; D048271:Chitosan