title: Nucleotide excision repair gene ERCC1 19007T>C polymorphism contributes to lung cancer susceptibility: a meta-analysis.
abstract: OBJECTIVE
  Association studies of ERCC1 19007T>C polymorphism and lung cancer have yielded inconsistent results, possibly because single studies often lack sufficient statistical power.
  
  
  METHODS
  We examined the association by performing a meta-analysis. Two investigators independently searched the Google Scholar, PubMed, and CNKI Databases. Summary odds ratios (ORs) and 95% confidence intervals (95% CIs) for 19007T>C polymorphism and lung cancer were calculated in a fixed-effects model and a random-effects model, when appropriate. Publication bias was evaluated using Begg's funnel plot.
  
  
  RESULTS
  Overall, the meta-analysis included 7 case-control studies for each polymorphism with 3840 confirmed lung cancer cases and 4712 healthy controls in total. Meta-analysis results showed a significant association between 19007T>C polymorphism and lung cancer risk (CC vs. TT: OR=0.72, 95% CI 0.53-0.99; CT vs. TT: OR=0.84, 95% CI 0.73-0.98; Dominant model: OR=0.70, 95% CI 0.52-0.95). Further stratified analyses conducted by ethnicity reveal a statistically significant association in Asians (Dominant model: OR=0.63, 95% CI 0.43-0.93), but no significant association in Europeans.
  
  
  CONCLUSIONS
  This meta-analysis suggests that the ERCC1 19007T>C polymorphism may be associated with lung cancer risk in Asians, while larger scale association studies are necessary to further validate the association of 19007T>C polymorphism with lung cancer risk.
authors: 1 Department of Laboratory Medicine, Ningbo Medical Treatment Center, Lihuili Hospital , Ningbo, China .
authors: Fuyi
authors: F
authors: Xie
authors: Qi
authors: Q
authors: Sun
authors: Shengjun
authors: S
authors: Wu
authors: Xinyou
authors: X
authors: Xie
authors: Zhiwei
authors: Z
authors: Liu
mesh_terms: D044466:Asian People; D004268:DNA-Binding Proteins / Q000235:genetics*; D004720:Endonucleases / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000208:ethnology / Q000235:genetics*; D008297:Male; D008957:Models, Genetic; D009363:Neoplasm Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D039781:PubMed; D012307:Risk Factors; D044465:White People
chemical_list: D004268:DNA-Binding Proteins; D009363:Neoplasm Proteins; C071447:ERCC1 protein, human; D004720:Endonucleases