title: Topical and systemic antimicrobial therapy for venous leg ulcers.
abstract: OBJECTIVE
  Is treatment with topical or systemic antimicrobial agents associated with better venous leg ulcer healing compared with usual care (dressings and bandages without antimicrobials) or an alternative topical or systemic antimicrobial agent?
  
  
  CONCLUSIONS
  Available evidence, from underpowered pooled data, neither supports nor refutes an association of systemic antibiotic therapy with improved venous leg ulcer healing. Among topical antimicrobials, cadexomer iodine may be associated with better healing compared with usual care.
authors: School of Healthcare, Baines Wing, University of Leeds, England.
authors: Susan
authors: S
authors: O'Meara
authors: Cochrane Wounds Group, Department of Health Sciences, University of York, York, England.
authors: Rachel
authors: R
authors: Richardson
authors: Department of Medicine, University of Washington, Seattle4Department of Infectious Diseases, University of Geneva, Geneva, Switzerland5Green Templeton College, University of Oxford, Oxford, England.
authors: Benjamin A
authors: BA
authors: Lipsky
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D006801:Humans; D014647:Varicose Ulcer / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local