title: Metabolic disorders in patients operated for pancreatic cancer.
abstract: Adenocarcinoma of the pancreas presents a major threat with a 5-years survival rate of 5%. Whipple pancreaticoduodenectomy (PD) is the standard procedure for cephalo-pancreatic neoplasm. After an extended resection and reconstruction of superior gastrointestinal tract the digestive physiology might be heavily disrupted. A literature review of metabolic alterations of patients who suffered a major pancreatic resection is performed, regarding micronutrients, lipid absorption and pancreatogenic diabetes. Long-term survivors following PD generally have a satisfactory nutritional status although with subclinical iron, vitamin D and selenium deficiency. These patients should be followed-up also regarding these micronutrients and properly dietary supplemented when necessary, also considering the increased life expectancy. Approximately 17-25% of patients will develop insulin-dependent diabetes but pancreatogenic diabetics have elevated levels of serum insulin and minimal or absent response to food intake, as opposed to a type I diabetics, where insulin serum is normal or elevated and there is an exaggerated response to ingestion of sugar.
authors: D
authors: D
authors: Timofte
authors: Roxana
authors: R
authors: Livadariu
authors: V
authors: V
authors: Bintintan
authors: C
authors: C
authors: Diaconu
authors: Lidia
authors: L
authors: Ionescu
authors: A A
authors: AA
authors: Sandberg
authors: D C
authors: DC
authors: Mariciuc
authors: R
authors: R
authors: Dănilă
mesh_terms: D000230:Adenocarcinoma / Q000601:surgery*; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000209:etiology; D004435:Eating; D006801:Humans; D008017:Life Expectancy; D050356:Lipid Metabolism; D008659:Metabolic Diseases / Q000188:drug therapy* / Q000209:etiology* / Q000401:mortality; D018977:Micronutrients / Q000172:deficiency*; D009752:Nutritional Status; D010190:Pancreatic Neoplasms / Q000601:surgery*; D016577:Pancreaticoduodenectomy / Q000009:adverse effects*; D011184:Postoperative Period; D011788:Quality of Life; D014131:Trace Elements / Q000008:administration & dosage; D014815:Vitamins / Q000008:administration & dosage
chemical_list: D018977:Micronutrients; D014131:Trace Elements; D014815:Vitamins