title: Effects of caprylic triglyceride on cognitive performance and cerebral glucose metabolism in mild Alzheimer's disease: a single-case observation.
abstract: OBJECTIVE
  To examine the effect of 109 days of caprylic triglyceride (CT) in a 70-year-old male with mild Alzheimer's disease (AD).
  
  
  BACKGROUND
  Cerebral metabolism is limited to glucose under most conditions, and diminished cerebral glucose metabolism is a characteristic feature of AD. Another substrate available for cerebral metabolism is ketone bodies. Ketone bodies (KB) are normally derived from fat stores under conditions of low glucose availability as an alternative energy substrate to glucose. KB can also be produced by oral administration of CT. Prior studies suggest that the alternative energy source of CT may improve cognitive function due to mild to moderate AD, by circumventing the diminished glucose metabolism.
  
  
  METHODS
  The effect of CT was analyzed in a single-case of mild AD with cognitive alterations in an open label study. Study outcomes included the Montreal cognitive assessment (MoCA), mini mental state exam (MMSE), and 18-fluorodeoxyglucose (18F) positron emission tomography (FDG PET) scans.
  
  
  RESULTS
  After 109 days of CT, MoCA scores changed from a baseline value of 24-28, and MMSE scores changed from 23 to 28. No changes were observed on FDG PET scans.
  
  
  CONCLUSIONS
  The results suggest that, in a case of mild AD, CT may have affected cognitive function, assessed by means of MMSE and MoCA, although glucose uptake and metabolism remained unchanged.
authors: High Point Regional Division of University of North Carolina Health Care , High Point, NC , USA.
authors: Brian Andrew
authors: BA
authors: Farah
keywords: Alzheimer’s disease; Montreal cognitive assessment; apolipoprotein E; glucose; ketone bodies; mini mental state exam