title: Day/night changes of thymus-deriving natural regulatory T cell development and function.
abstract: Activity of the immune system shows day/night rhythmicity. Changes in the migration and biological activities of immune cells are strongly regulated by the HPA axis. Another mechanism governing the level of the immune response is based on the suppressive activity of natural regulatory T cells CD4+CD25+Foxp3+ (nTregs) which play a crucial role in the maintenance of self-tolerance and immune homeostasis. The aim of our study was to answer the question: are nTregs changing their development and suppressive activity according to day/night cycle? We demonstrated the effect of day time on nTreg distribution in the thymus and their suppressive potential to inhibit the proliferation of activated responder T cells.
authors: Department of Immunology, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland. Electronic address: ekiernozek@biol.uw.edu.pl.
authors: Ewelina
authors: E
authors: Kiernozek
authors: Department of Immunology, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland.
authors: Anna
authors: A
authors: Kowalik
authors: Department of Animal Physiology, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland.
authors: Magdalena
authors: M
authors: Markowska
authors: Department of Immunology, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland.
authors: Ewa
authors: E
authors: Kozlowska
authors: Department of Immunology, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland.
authors: Nadzieja
authors: N
authors: Drela
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000276:immunology; D049109:Cell Proliferation; D002940:Circadian Rhythm / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology; D016131:Lymphocyte Subsets / Q000166:cytology / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011965:Receptors, Glucocorticoid / Q000276:immunology; D012727:Sex Characteristics; D050378:T-Lymphocytes, Regulatory / Q000166:cytology* / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology* / Q000276:immunology*
chemical_list: D011965:Receptors, Glucocorticoid
keywords: Biological rhythms; Glucocorticoids; Natural regulatory T cells; Thymus-deriving natural regulatory T cells