title: Spectroscopic characterization and biological activity of dihydrazone transition metal complexes: crystal structure of 2,3-butanedione bis(isonicotinylhydrazone).
abstract: Metal complexes of the chloride, nitrate and acetate salts of Co(II), Ni(II) Cu(II), Zn(II), Cd(II) or Hg(II) with 2,3-butanedione bis(isonicotinylhydrazone) [BBINH] have been synthesized and structurally characterized. The crystal of BBINH was solved to crystallize as monoclinic system with space group of P121/c14. The formulae of the complexes were assigned based on the elemental analysis and mass spectra. The formation of BBINH complexes depend on the metal anion used. All complexes are nonelectrolytes except for the complexes 2, 3, 4 are (1:1) and 13 and 14 which are 1:2 electrolytes. BBINH behaves as a neutral tetradentate (N2O2) in the chloride complexes of Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II). In [Co2(BBINH)(H2O)Cl3]Cl⋅H2O, BBINH has the same dentate but with the two Co(II) ions. In the acetate complexes, [Ni2(BBINH-2H)(H2O)2(OAc)2]⋅3H2O and [Cu2(BBINH-2H)(OAc)2]⋅5H2O, BBINH acts as a binegative tetradentate with the two metal ions. The ligand in the nitrate complexes acts as a neutral bidentate via the two hydrazone azomethine C=NHy; the nitrate ions are ionic in the Cd(II) and Zn(II) complexes and covalent in the Ni(II) complex. The data are supported by NMR ((1)H and (13)C) spectra. The magnetic moments and electronic spectra of all complexes provide tetrahedral, square planar and/or octahedral structure. The decomposition of the complexes revealed the outer and inner solvents as well as the remaining residue based on TGA. The complexes have variable activities against some bacteria and fungi. The ligand is inactive against all tested organisms. The activity of Cd(II) and Hg(II) may be related to the geometry of the complexes.
authors: Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt.
authors: Ahmed E M
authors: AE
authors: El-Sayed
authors: Chemistry Department, Faculty of Science, Kuwait University, Kuwait.
authors: O A
authors: OA
authors: Al-Fulaij
authors: Chemistry Department, Faculty of Science, Kuwait University, Kuwait; Chemistry Department, Faculty of Science, Helwan University, Egypt.
authors: A A
authors: AA
authors: Elaasar
authors: Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt.
authors: M M
authors: MM
authors: El-Defrawy
authors: Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt; Chemistry Department, Faculty of Science, Kuwait University, Kuwait. Electronic address: aelasmy@yahoo.com.
authors: A A
authors: AA
authors: El-Asmy
mesh_terms: D001419:Bacteria / Q000187:drug effects; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004583:Electrons; D005658:Fungi / Q000187:drug effects; D006835:Hydrazones / Q000737:chemistry* / Q000494:pharmacology*; D008024:Ligands; D060328:Magnetic Phenomena; D008826:Microbial Sensitivity Tests; D008970:Molecular Weight; D066244:Proton Magnetic Resonance Spectroscopy; D013055:Spectrophotometry, Infrared; D013818:Thermogravimetry; D028561:Transition Elements / Q000494:pharmacology*; D044366:Transition Temperature
chemical_list: C000598539:2,3-butanedione bis(isonicotinylhydrazone); D056831:Coordination Complexes; D006835:Hydrazones; D008024:Ligands; D028561:Transition Elements
keywords: 2,3-Butanedione bis(isonicotinylhydrazone); Antimicrobial activity; Transition metal complexes; X-ray spectroscopy