title: Four polymorphisms in the cytochrome P450 1A2 (CYP1A2) gene and lung cancer risk: a meta-analysis.
abstract: BACKGROUND
  Previous published data on the association between CYP1A2 rs762551, rs2069514, rs2069526, and rs2470890 polymorphisms and lung cancer risk have not allowed a definite conclusion. The present meta-analysis of the literature was performed to derive a more precise estimation of the relationship.
  
  
  METHODS
  8 publications covering 23 studies were selected for this meta-analysis, including 1,665 cases and 2,383 controls for CYP1A2 rs762551 (from 8 studies), 1,456 cases and 1,792 controls for CYP1A2 rs2069514 (from 7 studies), 657 cases and 984 controls for CYP1A2 rs2069526 (from 5 studies) and 691 cases and 968 controls for CYP1A2 rs2470890 (from 3 studies).
  
  
  RESULTS
  When all the eligible studies were pooled into the meta-analysis for the CYP1A2 rs762551 polymorphism, significantly increased lung cancer risk was observed in the dominant model (OR=1.21, 95 % CI=1.00-1.46). In the subgroup analysis by ethnicity, significantly increased risk of lung cancer was observed in Caucasians (dominant model: OR=1.29, 95%CI=1.11-1.51; recessive model: OR=1.33, 95%CI=1.01-1.75; additive model: OR=1.49, 95%CI=1.12-1.98). There was no evidence of significant association between lung cancer risk and CYP1A2 rs2069514, s2470890, and rs2069526 polymorphisms.
  
  
  CONCLUSIONS
  In summary, this meta-analysis indicates that the CYP1A2 rs762551 polymorphism is linked to an increased lung cancer risk in Caucasians. Moreover, our work also points out the importance of new studies for rs2069514 associations in lung cancer, where at least some of the covariates responsible for heterogeneity could be controlled, to obtain a more conclusive understanding about the function of the rs2069514 polymorphism in lung cancer development.
authors: Department of Ultrasound, 2Department of Psychiatry, Zhejiang Hospital, Hangzhou, China E-mail : dryemeng@126.com.
authors: Zhi-Bin
authors: ZB
authors: Bu
authors: Meng
authors: M
authors: Ye
authors: Yun
authors: Y
authors: Cheng
authors: Wan-Zhen
authors: WZ
authors: Wu
mesh_terms: D019388:Cytochrome P-450 CYP1A2 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D044465:White People
chemical_list: C504573:CYP1A2 protein, human; D019388:Cytochrome P-450 CYP1A2