title: Plasma carotenoids and retinol and overall and breast cancer risk: a nested case-control study.
abstract: Experimental studies suggest that carotenoids and retinol may play a role in carcinogenesis, but epidemiological evidence is lacking. We investigated the prospective associations between plasma concentrations of major carotenoids and retinol, and overall and breast cancer risk. A nested case-control study included all first incident cancer cases diagnosed in the SU.VI.MAX cohort between 1994 and 2002 (n = 159 cases, 1 matched control/case). Baseline plasma concentrations of carotenoids and retinol were measured by high-performance liquid chromatography. Conditional logistic regression was used to assess odds ratios for an increase of 0.1 μmol/L [odds ratio (OR)] and 95% confidence intervals (CI). Plasma β-carotene (OR = 0.95, 95% CI = 0.90-0.99, Ptrend = 0.04) and β-cryptoxanthin concentrations (OR = 0.89, 95% CI = 0.81-0.99, Ptrend = 0.03) were inversely associated with overall cancer risk. Plasma β-cryptoxanthin concentration was inversely associated with breast cancer risk (OR = 0.83, 95% CI = 0.71-0.96, Ptrend = 0.02). The OR between plasma lycopene concentration and overall cancer risk was 1.07 (0.99-1.15), Ptrend = 0.06. This association turned significant (Ptrend = 0.01) when excluding cancer cases diagnosed during the first year of follow-up. This prospective study suggests an inverse association between plasma concentrations of β-cryptoxanthin and both overall and breast cancer risk, and an inverse association between β-carotene and overall cancer risk. The direct association between lycopene concentration and cancer risk deserves further investigation.
authors: a Sorbonne Paris Cité Research Center, Nutritional Epidemiology Research Team, Inserm U557, Inra U1125, Cnam , Paris 13 University , Bobigny , France.
authors: Camille
authors: C
authors: Pouchieu
authors: Pilar
authors: P
authors: Galan
authors: Véronique
authors: V
authors: Ducros
authors: Paule
authors: P
authors: Latino-Martel
authors: Serge
authors: S
authors: Hercberg
authors: Mathilde
authors: M
authors: Touvier
mesh_terms: D000328:Adult; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000097:blood*; D002338:Carotenoids / Q000097:blood; D016022:Case-Control Studies; D002851:Chromatography, High Pressure Liquid; D015179:Colorectal Neoplasms / Q000097:blood; D065366:Cryptoxanthins / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000097:blood; D006801:Humans; D016015:Logistic Models; D008175:Lung Neoplasms / Q000097:blood; D000077276:Lycopene; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000097:blood; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D014801:Vitamin A / Q000097:blood*; D019207:beta Carotene / Q000097:blood*
chemical_list: D065366:Cryptoxanthins; D019207:beta Carotene; D014801:Vitamin A; D002338:Carotenoids; D000077276:Lycopene