title: Vagifem is superior to vaginal Premarin in induction of endometrial thickness in the frozen-thawed cycle patients with refractory endometria: A randomized clinical trial.
abstract: BACKGROUND
  Embryo transfer to a developed endometrium is an important prognostic factor in frozen-thawed embryo transfer cycle outcome. Vaginal estrogen, such as Vagifem vaginal tablets and Premarin vaginal cream, is a regimen used for the patients with refractive endometria.
  
  
  OBJECTIVE
  Our objective was to compare the effects of Vagifem and Premarin on the endometrial thickness of the patients with refractive endometria.
  
  
  METHODS
  In this randomized clinical trial, 30 patients with refractive endometria in frozen-thawed embryo transfer cycles received Vagifem vaginal tablets and 30 women received Premarin vaginal cream. Endometrial thickness was measured on the 14th day of drug administration.
  
  
  RESULTS
  Comparing the endometrial thicknesses of the two groups showed that the endometria of the Vagifem group was significantly thicker than that of the Premarin group (5.93±0.38 vs. 6.74±0.32; p<0.001).
  
  
  CONCLUSIONS
  Vagifem is superior to Premarin in induction of endometrial thickness in frozen-thawed embryo transfer cycles in the patients with refractive endometria.
authors: Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. ; Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran.
authors: Jaleh
authors: J
authors: Zolghadri
authors: Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors: Hossein
authors: H
authors: Haghbin
authors: Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors: Nasrin
authors: N
authors: Dadras
authors: Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors: Shabnam
authors: S
authors: Behdin
keywords: Endometrium; Estradiol; Human; Infertility; Premarin