title: Consequences of dextropropoxyphene market withdrawal in elderly patients with chronic pain.
abstract: OBJECTIVE
  Describe the consequences of dextropropoxyphene (DXP) market withdrawal on analgesic prescriptions and on the quality of therapeutic management of chronic pain.
  
  
  METHODS
  From a cohort of non-institutionalised elderly patients with chronic pain recruited by general practitioners, we selected patients who were treated with DXP daily for at least 6 months just prior to DXP market withdrawal and who had an evaluation of pain and its impact on daily activities before and after DXP withdrawal.
  
  
  RESULTS
  One hundred three patients took DXP daily for chronic pain. Immediately after DXP market withdrawal, 42 (40.8%), 55 (53.4%) and 3 (2.9%) patients were treated with step 1, 2 and 3 analgesics, respectively, and 3 patients (2.9%) were no longer receiving any analgesic medication. Among the 55 patients who continued on step 2 analgesics, 37 were treated with tramadol, 14 with codeine and 9 with opium. Pain intensity and the impact of pain on daily activities remained stable.
  
  
  CONCLUSIONS
  DXP market withdrawal had no consequences on the intensity or impact of chronic pain in elderly patients.
authors: Pharmacology Department, Faculty of Medicine Paris-Sud, Assistance Publique-Hôpitaux de Paris, Hopital Bicêtre, University Paris-Sud,, Le Kremlin-Bicêtre, France, laurent.becquemont@bct.aphp.fr.
authors: Laurent
authors: L
authors: Becquemont
authors: Tiba
authors: T
authors: Delespierre
authors: Bernard
authors: B
authors: Bauduceau
authors: Linda
authors: L
authors: Benattar-Zibi
authors: Gilles
authors: G
authors: Berrut
authors: Emmanuelle
authors: E
authors: Corruble
authors: Nicolas
authors: N
authors: Danchin
authors: Geneviève
authors: G
authors: Derumeaux
authors: Jean
authors: J
authors: Doucet
authors: Bruno
authors: B
authors: Falissard
authors: Francoise
authors: F
authors: Forette
authors: Olivier
authors: O
authors: Hanon
authors: Florence
authors: F
authors: Pasquier
authors: Michel
authors: M
authors: Pinget
authors: Rissane
authors: R
authors: Ourabah
authors: Sophie
authors: S
authors: Bucher
authors: Aida
authors: A
authors: Lazkani
authors: Celine
authors: C
authors: Piedvache
authors: Philippe
authors: P
authors: Bertin
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D000700:Analgesics / Q000627:therapeutic use; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D059350:Chronic Pain / Q000188:drug therapy* / Q000503:physiopathology; D015331:Cohort Studies; D011431:Dextropropoxyphene / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D056737:Safety-Based Drug Withdrawals
chemical_list: D000700:Analgesics; D000701:Analgesics, Opioid; D011431:Dextropropoxyphene