title: Near-euglycemia can be achieved safely in pediatric total pancreatectomy islet autotransplant recipients using an adapted intravenous insulin infusion protocol.
abstract: BACKGROUND
  Children with severe chronic pancreatitis may undergo total pancreatectomy with islet autotransplantation (TPIAT) to relieve pain while minimizing the risk of postsurgical diabetes. Because overstimulation of transplanted islets by hyperglycemia can result in β-cell loss, we developed a specialized intravenous insulin infusion protocol (IIP) for pediatric TPIAT recipients to maintain euglycemia or near-euglycemia posttransplant.
  
  
  METHODS
  Our objective was to review glucose control using an IIP specific for TPIAT recipients at a single institution. We reviewed postoperative blood glucose (BG) levels for 32 children 4-18 years old with chronic pancreatitis who underwent TPIAT between July 2011 and June 2013. We analyzed the proportion of BG values in the range of 70-140 mg/dL, mean glucose, glucose variability, and occurrence of hypoglycemia during the IIP; we also evaluated the transition to subcutaneous therapy (first 72 h with multiple daily injections [MDI]).
  
  
  RESULTS
  During IIP, the mean patient BG level was 116±27 mg/dL, with 83.1% of all values in the range of 70-140 mg/dL. Hypoglycemia was rare, with only 2.5% of values <70 mg/dL. The more recent era (n=16) had a lower mean BG and less variability than the early era (first 16 patients) (P≤0.004). Mean glucose level (116 vs. 128 mg/dL) and glucose variability were significantly lower during the IIP compared with MDI therapy (P<0.0001).
  
  
  CONCLUSIONS
  Tight glycemic control without excessive severe hypoglycemia was achieved in children undergoing TPIAT using an IIP specifically designed for this population; the ability to maintain BG in target range improved with experience with the protocol.
authors: 1 Department of Pediatrics, University of Minnesota Medical Center and Amplatz Children's Hospital , Minneapolis, Minnesota.
authors: Gregory P
authors: GP
authors: Forlenza
authors: Srinath
authors: S
authors: Chinnakotla
authors: Sarah J
authors: SJ
authors: Schwarzenberg
authors: Marie
authors: M
authors: Cook
authors: David M
authors: DM
authors: Radosevich
authors: Carol
authors: C
authors: Manchester
authors: Sameer
authors: S
authors: Gupta
authors: Brandon
authors: B
authors: Nathan
authors: Melena D
authors: MD
authors: Bellin
mesh_terms: D000293:Adolescent; D064592:Autografts; D001786:Blood Glucose / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D002985:Clinical Protocols; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D015309:Glucose Clamp Technique; D006801:Humans; D007003:Hypoglycemia / Q000517:prevention & control*; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D007262:Infusions, Intravenous; D007332:Insulin Infusion Systems; D016381:Islets of Langerhans Transplantation; D008297:Male; D010180:Pancreatectomy; D050500:Pancreatitis, Chronic / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery*; D011184:Postoperative Period; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents