title: [Role of migraine history in the development of postoperative nausea and vomiting in patients undergoing general and combined general-epidural anesthesia].
abstract: OBJECTIVE
  To assess the role of migraine history in the development of postoperative nausea and vomiting (PONV) in patients undergoing general and combined general-epidural anaesthesia.
  
  
  METHODS
  127 women with oncogynecological pathology were randomized into 3 groups according to anaesthesia method. Patients of the group C (comparative group; n = 43; 18 with migraine) received general anaesthesia. Patients of the Group CA (n = 40; 19 with migraine) received combined general-epidural anaesthesia. Patients of the group D (n = 44; 19 with migraine) received general anaesthesia with adding of Droperidolum. All patients received standard prophylactics of PONV- Ondansetronum 8 mg and dexamethasone 8 mg intravenous.
  
  
  RESULTS
  In the group C a PONV occurred in 15 of 43 women (34.9%). PONV occurred in 6 of 18 women with migraine (33.3%) and in 9 of 25 women without migraine (36%). In the group CA a PONV occurred in 10 of 40 women (25%). PONV occurred in 8 of 19 women with migraine (42.1%) and in 2 of 21 women without migraine (9.5%; p = 0.036 in comparison with group C). In the group D a PONV occurred in 8 of 44 women (18.2%). PONV occurred in 1 of 19 women with migraine (5.3% p = 0.03 in comparison with group C and p = 0.008 with group CA) and in 7 of 25 women without migraine (28%; there was no significant difference with groups C and CA).
  
  
  CONCLUSIONS
  Migraine history is a significant risk factor of PONV. Epidural component of anaesthesia does not effect on frequency of PONV in women with migraine, but Droperidolum use allows increasing the frequency of PONV.
authors: V E
authors: VE
authors: Khoronenko
authors: D S
authors: DS
authors: Baskakov
mesh_terms: D000328:Adult; D000368:Aged; D000767:Anesthesia, Epidural / Q000379:methods*; D000768:Anesthesia, General / Q000379:methods*; D000932:Antiemetics / Q000627:therapeutic use; D003907:Dexamethasone / Q000627:therapeutic use; D004329:Droperidol / Q000627:therapeutic use; D005260:Female; D005833:Genital Neoplasms, Female / Q000601:surgery; D006801:Humans; D008875:Middle Aged; D008881:Migraine Disorders / Q000150:complications*; D017294:Ondansetron / Q000627:therapeutic use; D020250:Postoperative Nausea and Vomiting / Q000453:epidemiology / Q000209:etiology*; D012307:Risk Factors; D055815:Young Adult
chemical_list: D000932:Antiemetics; D017294:Ondansetron; D003907:Dexamethasone; D004329:Droperidol