title: Synthesis of novel derivatives of 4-methylbenzimidazole and evaluation of their biological activities.
abstract: 4-Methylbenzimidazole 1-28 novel derivatives were synthesized and evaluated for their antiglycation and antioxidant activities. Compounds 1-7 and 11 showed excellent activities ranged 140-280 μM, better than standard drug rutin (294.46 ± 1.50 μM). Compound 1-28 were also evaluated for DPPH activities. Compounds 1-8 showed excellent activities, ranging 12-29 μM, better than standard drug n-propylgallate (IC50 = 30.30 ± 0.40 μM). For superoxide anion scavenging activity, compounds 1-7 showed better activity than standard n-propylgallate (IC50 = 106.34 ± 1.6 μM), ranged 82-104 μM. These compounds were found to be nontoxic to THP-1 cells.
authors: Atta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 43200 Puncak Alam, Selonger, Malaysia; Faculty of Applied Science UiTM, 40450 Shah Alam, Selangor D. E., Malaysia. Electronic address: taha_hej@yahoo.com.
authors: Muhammad
authors: M
authors: Taha
authors: Atta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 43200 Puncak Alam, Selonger, Malaysia; Faculty of Applied Science UiTM, 40450 Shah Alam, Selangor D. E., Malaysia.
authors: Nor Hadiani
authors: NH
authors: Ismail
authors: Institute of Advance Research Studies in Chemical Sciences, University of Sindh Jamshoro, Pakistan.
authors: Waqas
authors: W
authors: Jamil
authors: Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam 42300, Selangor, Malaysia.
authors: Hesham
authors: H
authors: Rashwan
authors: Institute of Advance Research Studies in Chemical Sciences, University of Sindh Jamshoro, Pakistan.
authors: Syed Muhammad
authors: SM
authors: Kashif
authors: Malaysian Institute of Pharmaceuticals and Nutraceuticals, Ministry of Science, Technology and Innovation, Bangunan Pentadbiran, Blok 5-A, Halaman Bukit Gambir,11700 Bayan Lepas, Penang, Malaysia.
authors: Amyra Amat
authors: AA
authors: Sain
authors: Atta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 43200 Puncak Alam, Selonger, Malaysia; Malaysian Institute of Pharmaceuticals and Nutraceuticals, Ministry of Science, Technology and Innovation, Bangunan Pentadbiran, Blok 5-A, Halaman Bukit Gambir,11700 Bayan Lepas, Penang, Malaysia; Forest Research Institute Malaysia (FRIM), 52109 Kepong, Selangor, Malaysia.
authors: Mohd Ilham
authors: MI
authors: Adenan
authors: Atta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 43200 Puncak Alam, Selonger, Malaysia.
authors: El Hassane
authors: el H
authors: Anouar
authors: Center for Advanced Drug Research, COMSATS Institute of Information Technology, University Road, Abbottabad 22060, KPK, Pakistan.
authors: Muhammad
authors: M
authors: Ali
authors: Department of Chemistry, Hazara University, Mansehra, Pakistan.
authors: Fazal
authors: F
authors: Rahim
authors: H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
authors: Khalid M
authors: KM
authors: Khan
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001562:Benzimidazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D006031:Glycosylation / Q000187:drug effects; D006801:Humans; D007891:Leishmania / Q000187:drug effects; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests
chemical_list: D000975:Antioxidants; D000981:Antiprotozoal Agents; D001562:Benzimidazoles
keywords: Antiglycation; Antileishmanial; Antioxidant; Benzimidazole; Stereoisomers