title: Tracing the evolution of multi-scale functional networks in a mouse model of depression using persistent brain network homology.
abstract: Many brain diseases or disorders, such as depression, are known to be associated with abnormal functional connectivity in neural networks in the brain. Some bivariate measures of electroencephalography (EEG) for coupling analysis have been used widely in attempts to explain abnormalities related with depression. However, brain network evolution based on persistent functional connections in EEG signals could not be easily unveiled. For a geometrical exploration of brain network evolution, here, we used persistent brain network homology analysis with EEG signals from a corticosterone (CORT)-induced mouse model of depression. EEG signals were obtained from eight cortical regions (frontal, somatosensory, parietal, and visual cortices in each hemisphere). The persistent homology revealed a significantly different functional connectivity between the control and CORT model, but no differences in common coupling measures, such as cross correlation and coherence, were apparent. The CORT model showed a more localized connectivity and decreased global connectivity than the control. In particular, the somatosensory and parietal cortices were loosely connected in the CORT model. Additionally, the CORT model displayed altered connections among the cortical regions, especially between the frontal and somatosensory cortices, versus the control. This study demonstrates that persistent homology is useful for brain network analysis, and our results indicate that the CORT-induced depression mouse model shows more localized and decreased global connectivity with altered connections, which may facilitate characterization of the abnormal brain network underlying depression.
authors: Brain Behavior and Therapeutics Lab., Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
authors: Arshi
authors: A
authors: Khalid
authors: Brain Behavior and Therapeutics Lab., Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
authors: Byung Sun
authors: BS
authors: Kim
authors: Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI 53705, USA; Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin, Madison, WI 53705, USA.
authors: Moo K
authors: MK
authors: Chung
authors: Bio Imaging & Signal Processing Lab., Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea. Electronic address: jong.ye@kaist.ac.kr.
authors: Jong Chul
authors: JC
authors: Ye
authors: Brain Behavior and Therapeutics Lab., Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea. Electronic address: clark@kaist.ac.kr.
authors: Daejong
authors: D
authors: Jeon
mesh_terms: D000818:Animals; D001931:Brain Mapping / Q000379:methods*; D003863:Depression / Q000503:physiopathology*; D004195:Disease Models, Animal; D004569:Electroencephalography / Q000379:methods*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009415:Nerve Net / Q000503:physiopathology*
keywords: Depression; EEG; Functional connectivity; Mouse; Persistent brain network homology