title: Optic pathway gliomas: a review.
abstract: Optic pathway gliomas account for 3-5% of all pediatric CNS tumors and represent the most common intrinsic optic nerve tumors. These tumors occur preferentially during the first decade of life and are particularly frequent in children with neurofibromatosis type 1. Although optic pathway gliomas are low-grade tumors, their behavior can be aggressive, and their management is often challenging. Their management includes observation, surgery, chemotherapy and radiation. The role of each modality is discussed as well as current and future developments in treatment, in particular targeted therapies that are currently being investigated.
authors: The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.
authors: Iris
authors: I
authors: Fried
authors: Uri
authors: U
authors: Tabori
authors: Tarik
authors: T
authors: Tihan
authors: Arun
authors: A
authors: Reginald
authors: Eric
authors: E
authors: Bouffet
mesh_terms: D006801:Humans; D009456:Neurofibromatosis 1 / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D020339:Optic Nerve Glioma / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D019574:Optic Nerve Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D014786:Vision Disorders / Q000209:etiology