title: Lack of any prognostic role of insulin-like growth factor-1 receptor in non-small cell lung cancer.
abstract: BACKGROUND
  The purpose of this study is to determine whether the IGF1R expression has a prognostic role in non-small cell lung cancer.
  
  
  METHODS
  Forty-seven patients histopathologically diagnosed with small cell lung cancer upon bronchoscopic biopsy or resection materials were included in the study. IGF1R expression was examined via immunohistochemical methods. In samples, >10% staining were assessed as positive and ≤10% as negative. Information about demographic datas and treatments was obtained by retrospective searches of patient files.
  
  
  RESULTS
  IGF1R expression was determined as positive in 38 (80.9%) and as negative in 9 (19.1%) patients. There was no significant relation between IGF1R expression and histological sub-type, local invasion, lymph node and metastasis status (p=0.842, p=0.437, 0.064, 0.447, respectively). There was also no correlation with IGF1R expression and survival (p=0.141).
  
  
  CONCLUSIONS
  There are conflicting results between IGF1R and its prognostic effects in the various studies. It has been claimed in some studies it is not related to prognosis as in our study, and in some studies it has been claimed that it is a good prognostic factor whereas in some studies it has been claimed as being a factor for worse prognosis. We think that IGF1R expression in non-small cell lung carcinoma patients deserves further analysis, because of its potential prognostic and predictive roles.
authors: Department of Medical Oncology, Antalya Education and Research Hospital, Antalya, Turkey E-mail : drsgunduz@gmail.com.
authors: Utku Donem
authors: UD
authors: Dilli
authors: Mustafa
authors: M
authors: Yildırim
authors: Dinc
authors: D
authors: Suren
authors: Arsenal
authors: A
authors: Alikanoglu
authors: Vildan
authors: V
authors: Kaya
authors: Sevil
authors: S
authors: Goktas
authors: Mustafa
authors: M
authors: Yildiz
authors: Cem
authors: C
authors: Sezer
authors: Seyda
authors: S
authors: Gunduz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D017451:Receptors, Somatomedin / Q000096:biosynthesis*; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor; C583557:IGF1 protein, human; D017451:Receptors, Somatomedin; D007334:Insulin-Like Growth Factor I