title: Genetic analysis of an orbital metastasis from a primary hepatic neuroendocrine carcinoma.
abstract: A 71-year-old female with a known history of primary hepatic neuroendocrine carcinoma, presented with a visual defect, proptosis and restricted eye movements of the right eye. Biopsies from the orbit and from the primary hepatic neuroendocrine carcinoma showed similar morphological and immunohistochemical features, and high-resolution, array-based comparative genomic hybridization demonstrated loss of one copy each of chromosomes 3 and 18, and gain of 1q both in the primary hepatic neuroendocrine carcinoma and in the orbital tumour. The orbital mass was diagnosed as a metastasis from the primary hepatic neuroendocrine carcinoma. Primary hepatic neuroendocrine tumours are extremely rare, and the orbit is an extremely rare location for a neuroendocrine carcinoma metastasis. This is the first reported case of an orbital metastasis with origin from a primary hepatic neuroendocrine carcinoma.
authors: Eye Pathology Institute, Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
authors: Jacob Ø
authors: JØ
authors: Rasmussen
authors: Eye Pathology Institute, Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
authors: Sarah L
authors: SL
authors: von Holstein
authors: Eye Pathology Institute, Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
authors: Jan U
authors: JU
authors: Prause
authors: Department of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
authors: Ben
authors: B
authors: Vainer
authors: Department of Pathology, Herlev Hospital, University of Copenhagen, Herlev, Denmark.
authors: Alastair B
authors: AB
authors: Hansen
authors: Sahlgrenska Cancer Center, Department of Pathology, University of Gothenburg, Gothenburg, Sweden.
authors: André
authors: A
authors: Fehr
authors: Sahlgrenska Cancer Center, Department of Pathology, University of Gothenburg, Gothenburg, Sweden.
authors: Göran
authors: G
authors: Stenman
authors: Eye Pathology Institute, Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
authors: Steffen
authors: S
authors: Heegaard
mesh_terms: D000368:Aged; D018278:Carcinoma, Neuroendocrine / Q000235:genetics* / Q000556:secondary; D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1; D002887:Chromosomes, Human, Pair 18; D002893:Chromosomes, Human, Pair 3; D055028:Comparative Genomic Hybridization; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology; D009918:Orbital Neoplasms / Q000235:genetics* / Q000556:secondary