title: Emerging biomarkers in anaplastic oligodendroglioma: implications for clinical investigation and patient management.
abstract: Oligodendrogliomas are heterogeneous tumors with a variable response to treatment. This clinical variability underlines the urgent need for markers that can reliably aid diagnosis and guide clinical decision-making. Long-term follow-up data from the EORTC 26951 and RTOG 9402 clinical trials in newly diagnosed anaplastic oligodendroglioma have established chromosome 1p19q codeletion as a predictive marker of response to procarbazine, lomustine and vincristine chemotherapy in anaplastic oligodendrogliomas. In addition, MGMT promoter hypermethylation has been strongly associated with glioma CpG island hypermethylation phenotype (G-CIMP+) status, this has been suggested as an epiphenomenon of genome-wide methylation, conferring a more favorable prognosis. Molecular profiling of these tumors has identified several other markers with potential clinical significance: mutations of IDH, CIC, FUBP1 and CDKN2A require further validation before they can be implemented as clinical decision-making tools. Additionally, recent data on the clinical significance of intrinsic glioma subtyping appears promising. Indeed, existing evidence suggests that comprehensive analyses such as intrinsic glioma subtyping or G-CIMP status are superior to single molecular markers. Clearly, with evolving treatment strategies and in the era of individualized therapy, broader omics-based molecular evaluations are required to improve outcome prediction and to identify patients who will benefit from specific treatment strategies.
authors: Pencer Brain Tumor Centre, Princess Margaret Cancer Center, 610 University Avenue, Toronto, ON, M5G 2M9, Canada.
authors: Solmaz
authors: S
authors: Sahebjam
authors: Mairéad G
authors: MG
authors: McNamara
authors: Warren P
authors: WP
authors: Mason
mesh_terms: D015415:Biomarkers; D001932:Brain Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D002872:Chromosome Deletion; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000235:genetics; D015254:DNA Modification Methylases / Q000235:genetics; D019468:Disease Management; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics; D008137:Longitudinal Studies; D009154:Mutation / Q000235:genetics; D009837:Oligodendroglioma / Q000175:diagnosis / Q000235:genetics / Q000628:therapy
chemical_list: D015415:Biomarkers; D019941:Cyclin-Dependent Kinase Inhibitor p16; D007521:Isocitrate Dehydrogenase; D015254:DNA Modification Methylases