title: Stepwise encapsulation and controlled two-stage release system for cis-Diamminediiodoplatinum.
abstract: cis-Diamminediiodoplatinum (cis-DIDP) is a cisplatin-like anticancer drug with higher anticancer activity, but lower stability and price than cisplatin. In this study, a cis-DIDP carrier system based on micro-sized stearic acid was prepared by an emulsion solvent evaporation method. The maximum drug loading capacity of cis-DIDP-loaded solid lipid nanoparticles was 22.03%, and their encapsulation efficiency was 97.24%. In vitro drug release in phosphate-buffered saline (pH =7.4) at 37.5°C exhibited a unique two-stage process, which could prove beneficial for patients with tumors and malignancies. MTT (3-[4,5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide) assay results showed that cis-DIDP released from cis-DIDP-loaded solid lipid nanoparticles had better inhibition activity than cis-DIDP that had not been loaded.
authors: Department of Chemistry, Key Laboratory of Yangtze River Water Environment, Ministry of Education, Tongji University, Shanghai, People's Republic of China.
authors: Yun
authors: Y
authors: Chen
authors: Department of Chemistry, Key Laboratory of Yangtze River Water Environment, Ministry of Education, Tongji University, Shanghai, People's Republic of China ; Shanghai Institute of Quality Inspection and Technical Research, Shanghai, People's Republic of China.
authors: Qian
authors: Q
authors: Li
authors: Department of Chemistry, Key Laboratory of Yangtze River Water Environment, Ministry of Education, Tongji University, Shanghai, People's Republic of China.
authors: Qingsheng
authors: Q
authors: Wu
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000493:pharmacokinetics* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002945:Cisplatin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry* / Q000493:pharmacokinetics; D004655:Emulsions / Q000737:chemistry; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D013229:Stearic Acids / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D004655:Emulsions; D013229:Stearic Acids; C073824:diammine-diiodoplatin; C031183:stearic acid; D002945:Cisplatin
keywords: cis-DIDP; drug delivery; emulsion solvent evaporation method; in vitro; stearic acid