title: Determination of regional lung air volume distribution at mid-tidal breathing from computed tomography: a retrospective study of normal variability and reproducibility.
abstract: BACKGROUND
  Determination of regional lung air volume has several clinical applications. This study investigates the use of mid-tidal breathing CT scans to provide regional lung volume data.
  
  
  METHODS
  Low resolution CT scans of the thorax were obtained during tidal breathing in 11 healthy control male subjects, each on two separate occasions. A 3D map of air volume was derived, and total lung volume calculated. The regional distribution of air volume from centre to periphery of the lung was analysed using a radial transform and also using one dimensional profiles in three orthogonal directions.
  
  
  RESULTS
  The total air volumes for the right and left lungs were 1035 +/- 280 ml and 864 +/- 315 ml, respectively (mean and SD). The corresponding fractional air volume concentrations (FAVC) were 0.680 +/- 0.044 and 0.658 +/- 0.062. All differences between the right and left lung were highly significant (p < 0.0001). The coefficients of variation of repeated measurement of right and left lung air volumes and FAVC were 6.5% and 6.9% and 2.5% and 3.6%, respectively. FAVC correlated significantly with lung space volume (r = 0.78) (p < 0.005). FAVC increased from the centre towards the periphery of the lung. Central to peripheral ratios were significantly higher for the right (0.100 +/- 0.007 SD) than the left (0.089 +/- 0.013 SD) (p < 0.0001).
  
  
  CONCLUSIONS
  A technique for measuring the distribution of air volume in the lung at mid-tidal breathing is described. Mean values and reproducibility are described for healthy male control subjects. Fractional air volume concentration is shown to increase with lung size.
authors: National Institute of Health Research Biomedical Research Unit in Respiratory Disease, University Hospital Southampton NHS Foundation Trust, Southampton, UK. john.fleming@uhs.nhs.uk.
authors: John
authors: J
authors: Fleming
authors: Joy
authors: J
authors: Conway
authors: Caroline
authors: C
authors: Majoral
authors: Michael
authors: M
authors: Bennett
authors: Georges
authors: G
authors: Caillibotte
authors: Spyridon
authors: S
authors: Montesantos
authors: Ira
authors: I
authors: Katz
mesh_terms: D000328:Adult; D064368:Healthy Volunteers; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging*; D008176:Lung Volume Measurements / Q000379:methods; D008297:Male; D008875:Middle Aged; D011857:Radiographic Image Interpretation, Computer-Assisted; D012189:Retrospective Studies; D013990:Tidal Volume; D014057:Tomography, X-Ray Computed / Q000379:methods*; D055815:Young Adult