title: Location, location, location: The relationship of anatomic site, antigen expression, and T-cell infiltration in human melanoma metastases.
abstract: Metastatic cell heterogeneity presents a significant obstacle to the development of targeted molecular and immunotherapeutics. Profiling of melanocyte differentiation antigens has revealed a nonstochastic, site-specific pattern of expression in metastases that was highest in brain, intermediate in soft tissues/lymph nodes, and lowest in visceral sites. Site-specific antigen heterogeneity, thus, is an important confounding factor to consider when assessing the potential efficacy of antigen-specific therapies.
authors: Center for Cancer Research, Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
authors: Edmund K
authors: EK
authors: Bartlett
authors: Center for Cancer Research, Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
authors: Udai S
authors: US
authors: Kammula
keywords: differentiation antigen; immunoediting; melanoma; metastases; site-specific expression