title: Ethnicity moderates dementia's biomarkers.
abstract: We have employed structural equation models to explicitly distinguish functional status, and therefore "dementia-relevant" variance in cognitive task performance (i.e., "δ"). We previously associated δ with cytokines and other serum biomarkers in a well characterized Alzheimer's disease cohort, the Texas Alzheimer's Research and Care Consortium. However, that δ homolog did not exhibit factor equivalence across ethnicity. In this study, we construct a δ homolog that exhibits mean and factor equivalence across ethnicity [i.e., "d(=)"]. d(=) is associated significantly with ten of the twelve previously selected biomarkers. Most of these associations are again specific to Non-Hispanic White participants. These findings have yet to be validated in other cohorts, but may suggest cross-ethnic differences in dementia's pathobiological mechanisms between Hispanic Mexican-Americans and Non-Hispanic Whites.
authors: Department of Psychiatry, The University of Texas Health Science Center, San Antonio, TX, USA Department of Medicine, The University of Texas Health Science Center, San Antonio, TX, USA Department of Family and Community Medicine, The University of Texas Health Science Center, San Antonio, TX, USA South Texas Veterans' Health System, Audie L. Murphy Division, GRECC, San Antonio, TX, USA.
authors: Donald R
authors: DR
authors: Royall
authors: Department of Family and Community Medicine, The University of Texas Health Science Center, San Antonio, TX, USA.
authors: Raymond F
authors: RF
authors: Palmer
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D003627:Data Interpretation, Statistical; D003704:Dementia / Q000097:blood* / Q000208:ethnology* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D017058:Mexican Americans; D015999:Multivariate Analysis; D009483:Neuropsychological Tests; D012372:ROC Curve; D044465:White People
chemical_list: D015415:Biomarkers
keywords: Aging; Hispanic; cognition; dementia; functional status; g