title: Chain-growth polyglycosylation: synthesis of linker-equipped mannosyl oligomers.
abstract: Direct syntheses of acetylated poly-mannosides can be achieved in one-step starting from a fully acetylated thioglycoside mannosyl donor using a polymerization-type strategy under the correct conditions. Under conditions that allow polymer growth from non-reducing to reducing end (N→R), different acceptor alcohols can be used as the 'terminating acceptors' to install different linkers at the reducing terminus. The efficiency is dependent on substituents of the linker, its length, temperature and choice of Lewis acid activator.
authors: Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, OX1 3TA Oxford, United Kingdom.
authors: Heiko J
authors: HJ
authors: Schuster
authors: Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, OX1 3TA Oxford, United Kingdom.
authors: Balakumar
authors: B
authors: Vijayakrishnan
authors: Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, OX1 3TA Oxford, United Kingdom. Electronic address: ben.davis@chem.ox.ac.uk.
authors: Benjamin G
authors: BG
authors: Davis
mesh_terms: D000438:Alcohols / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic; D006031:Glycosylation; D008362:Mannosides / Q000138:chemical synthesis* / Q000737:chemistry*; D058105:Polymerization; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D008362:Mannosides
keywords: Glycosylation; Mannosides; Polymerization; Rearrangement; Regioselective synthesis; Stereoselective synthesis