title: 2-(2-phenylethyl)chromone derivatives from Chinese agarwood induced by artificial holing.
abstract: Three new 2-(2-phenylethyl)chromone derivatives (1-3), together with thirteen known ones (4-16), were isolated from the EtOAc extract of Chinese agarwood induced by artificial holing, originating from Aquilaria sinensis (Lour.) Gilg (Thymelaeaceae). The chemical structures of the new compounds were identified by spectroscopic techniques (UV, IR, MS, 1D and 2D NMR). Compounds 1, 6, 15 and 16 exhibited inhibitory effects on Staphylococcus aureus, and compounds 15 and 16 showed inhibitory effects on Ralstonia solanacearum. Compounds 1-3, 7, 9, 11, 12, 15 and 16 exhibited acetylcholinesterase inhibitory activity. A possible biogenetic pathway of compounds 1-16 was proposed to show the relationships between diepoxy-tetrahydro-2-(2-phenylethyl)chromones, epoxy-tetrahydro-2-(2-phenylethyl) chromones, tetrahydro-2-(2-phenylethyl)chromones, and 2-(2-phenylethyl)chromones of the flidersia type, the four main types of 2-(2-phenylethyl)chromones found in agarwood, on the basis of their appearances in different stage of agarwood formation.
authors: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China.
authors: Wei
authors: W
authors: Li
authors: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China.
authors: Cai-Hong
authors: CH
authors: Cai
authors: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China.
authors: Wen-Hua
authors: WH
authors: Dong
authors: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China.
authors: Zhi-Kai
authors: ZK
authors: Guo
authors: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China.
authors: Hao
authors: H
authors: Wang
authors: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China. Electronic address: meiwenli@itbb.org.cn.
authors: Wen-Li
authors: WL
authors: Mei
authors: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China. Electronic address: daihaofu@itbb.org.cn.
authors: Hao-Fu
authors: HF
authors: Dai
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002800:Cholinesterase Inhibitors / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry*; D015394:Molecular Structure; D043367:Ralstonia / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D029645:Thymelaeaceae / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D002800:Cholinesterase Inhibitors; D005419:Flavonoids; C062550:2-(2-phenylethyl)chromone
keywords: 2-(2-Phenylethy)chromone derivatives; AChE inhibitory activity; Antibacterial activities; Aquilaria sinensis; Chinese agarwood induced by artificial holing; Possible biogenetic pathway; Thymelaeaceae