title: Targeted therapies in advanced renal cell carcinoma: the role of metastatic sites as a prognostic factor.
abstract: OBJECTIVE
  This retrospective study evaluates whether metastatic sites were associated with progression-free survival (PFS) and overall survival (OS) in patients with renal cell carcinoma treated with targeted therapies.
  
  
  METHODS
  In total, 358 patients were analyzed.
  
  
  CONCLUSIONS
  After a median follow-up of 56.1 months, median PFS was 11 months and median OS was 24.2 months. Metastatic sites were associated with PFS: lymph nodes (HR: 1.43; 95% CI: 1.12-1.83; p = 0.004), liver (HR: 1.41; 95% CI: 1.05-1.90; p = 0.021), bone (HR: 1.26; 95% CI: 0.96-1.65; p = 0.091), brain (HR: 0.81; 95% CI: 0.46-1.43; p = 0.474) and other sites (HR: 1.07; 95% CI: 0.83-1.38; p = 0.589). Metastatic sites were associated with OS: lymph nodes (HR: 1.73; 95% CI: 1.31-2.29; p < 0.001), liver (HR: 1.71; 95% CI: 1.23-2.37; p = 0.002), bone (HR: 1.48; 95% CI: 1.10-1.98; p = 0.009), brain (HR: 1.21; 95% CI: 0.64-2.28; p = 0.568) and other sites (HR: 1.09; 95% CI: 0.81-1.47; p = 0.568). Patients with >2 metastatic sites had shorter PFS and OS. Every association was lost when introducing the Motzer score in regression models.
authors: Medical Oncology 1, Fondazione IRCCS, Istituto Nazionale Tumori, Milan, Italy.
authors: Paolo
authors: P
authors: Grassi
authors: Elena
authors: E
authors: Verzoni
authors: Luca
authors: L
authors: Porcu
authors: Isabella
authors: I
authors: Testa
authors: Roberto
authors: R
authors: Iacovelli
authors: Valter
authors: V
authors: Torri
authors: Filippo de
authors: Fd
authors: Braud
authors: Giuseppe
authors: G
authors: Procopio
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002292:Carcinoma, Renal Cell / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D058990:Molecular Targeted Therapy; D060787:Neoplasm Grading; D009362:Neoplasm Metastasis; D011379:Prognosis; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: metastasis; prognostic factors; renal cell carcinoma; targeted therapies