title: Viscous optical clearing agent for in vivo optical imaging.
abstract: By allowing more photons to reach deeper tissue, the optical clearing agent (OCA) has gained increasing attention in various optical imaging modalities. However, commonly used OCAs have high fluidity, limiting their applications in in vivo studies with oblique, uneven, or moving surfaces. In this work, we reported an OCA with high viscosity. We measured the properties of this viscous OCA, and tested its successful performances in the imaging of a living animal’s skin with two optical imaging modalities: photoacoustic microscopy and optical coherence tomography. Our results demonstrated that the viscous OCA has a great potential in the study of different turbid tissues using various optical imaging modalities.
authors: Peking University, College of Engineering, Department of Biomedical Engineering, No. 5 Yiheyuan Road, Haidian, Beijing 100871, China.
authors: Zijian
authors: Z
authors: Deng
authors: Harbin Institute of Technology, School of Life Science and Technology, Harbin 150001, China.
authors: Lijia
authors: L
authors: Jing
authors: Peking University, College of Engineering, Department of Biomedical Engineering, No. 5 Yiheyuan Road, Haidian, Beijing 100871, China.
authors: Ning
authors: N
authors: Wu
authors: Peking University, College of Engineering, Department of Mechanics and Engineering Science, Beijing 100871, China.
authors: Pengyu
authors: P
authors: Lv
authors: Peking University, College of Engineering, Department of Biomedical Engineering, No. 5 Yiheyuan Road, Haidian, Beijing 100871, China.
authors: Xiaoyun
authors: X
authors: Jiang
authors: Peking University, College of Engineering, Department of Biomedical Engineering, No. 5 Yiheyuan Road, Haidian, Beijing 100871, China.
authors: Qiushi
authors: Q
authors: Ren
authors: Peking University, College of Engineering, Department of Biomedical Engineering, No. 5 Yiheyuan Road, Haidian, Beijing 100871, China.
authors: Changhui
authors: C
authors: Li
mesh_terms: D000818:Animals; D003879:Dermatologic Agents / Q000737:chemistry*; D051379:Mice; D008807:Mice, Inbred BALB C; D008853:Microscopy / Q000379:methods*; D061088:Photoacoustic Techniques / Q000379:methods*; D011092:Polyethylene Glycols / Q000737:chemistry; D011145:Polyvinyls / Q000737:chemistry; D011759:Pyrrolidines / Q000737:chemistry; D051381:Rats; D012867:Skin / Q000737:chemistry; D013829:Thiadiazines / Q000737:chemistry; D041623:Tomography, Optical Coherence / Q000379:methods*; D014783:Viscosity
chemical_list: D003879:Dermatologic Agents; D011145:Polyvinyls; D011759:Pyrrolidines; D013829:Thiadiazines; C505150:poly(N-vinylpyrrolidine); D011092:Polyethylene Glycols; C012864:dazomet