title: One-pot oxidation and rearrangement of propargylamines and in situ pyrazole synthesis.
abstract: Reported here are procedures for a one-pot oxidation and rearrangement of propargylamines to synthesize enaminones, with supporting mechanistic studies. Also reported are the extended one-pot syntheses of pyrazoles, including celecoxib and various heterocyclic compounds.
authors: Pfizer Worldwide R&D, Eastern Point Road, Groton, Connecticut 06340, United States.
authors: Jinshan
authors: J
authors: Chen
authors: Roberta
authors: R
authors: Properzi
authors: Daniel P
authors: DP
authors: Uccello
authors: Jennifer A
authors: JA
authors: Young
authors: Russell G
authors: RG
authors: Dushin
authors: Jeremy T
authors: JT
authors: Starr
mesh_terms: D002384:Catalysis; D000068579:Celecoxib; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010293:Pargyline / Q000031:analogs & derivatives* / Q000737:chemistry; D011437:Propylamines / Q000737:chemistry*; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D011437:Propylamines; D011720:Pyrazoles; D013449:Sulfonamides; C009054:propargylamine; D010293:Pargyline; D000068579:Celecoxib