title: Acute myeloid leukemia with t(10;11): a pathological entity with distinct clinical presentation.
abstract: BACKGROUND
  Acute myeloid leukemias with MLL rearrangements are frequently associated with myelomonocytic and monoblastic/monocytic morphology, with an increased risk of leukocytosis and leukostasis-related complications. Yet, little is known regarding the clinical presentation of adult AML patients with MLL translocations based on the specific translocation partner.
  
  
  METHODS
  Two recent AML cases with t(10;11)(p12;q23) translocations are detailed, with their shared presenting symptoms highlighted, followed by a review of the current literature.
  
  
  RESULTS
  The specific t(10;11)(p12;q23) MLL translocation is a rare recurrent translocation partner, most commonly seen in pediatric and young adult AML. A high incidence of early morbidity from leukocytosis-related complications are frequently seen, including diffuse intravascular coagulation and tumor lysis syndrome with multiorgan system failure, even without a true leukocytosis.
  
  
  CONCLUSIONS
  With prompt therapy and intensive supportive care first remissions are frequently attained, however, patients have a high risk of relapse, extramedullary disease, and poor long-term outcomes.
authors: Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX. Electronic address: cdinardo@mdanderson.org.
authors: Courtney D
authors: CD
authors: DiNardo
authors: Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX.
authors: Guilin
authors: G
authors: Tang
authors: Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX.
authors: Naveen
authors: N
authors: Pemmaraju
authors: Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX.
authors: Sa A
authors: SA
authors: Wang
authors: Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX.
authors: Allison
authors: A
authors: Pike
authors: Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX.
authors: Guillermo
authors: G
authors: Garcia-Manero
authors: Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX.
authors: Jorge
authors: J
authors: Cortes
authors: Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX.
authors: Carlos
authors: C
authors: Bueso-Ramos
authors: Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX.
authors: Hagop M
authors: HM
authors: Kantarjian
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D002871:Chromosome Banding; D002879:Chromosomes, Human, Pair 10; D002880:Chromosomes, Human, Pair 11; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic; D016896:Treatment Outcome; D055815:Young Adult
keywords: AML; DIC; Leukostasis; MLL; TLS