title: Total synthesis of (±)-nardoaristolone B and its analogues.
abstract: The first total synthesis of nardoaristolone B, a nor-sesquiterpenoid with an unusual fused ring system and having protective effects on the injury of neonatal rat cardiomyocytes, has been accomplished. Stereoselective synthesis of its novel analogues inlcuding exo-cyclopropyl ring fusion is also part of this disclosure. In addition, an alternate and more efficient one-step method to make a 3/5/6 tricyclic ring system using the Robinson annulation method has been developed toward the generation of a library of compounds around this skeleton.
authors: CSIR-National Chemical Laboratory , Division of Organic Chemistry, Dr. Homi Bhabha Road, Pune, 411008, India.
authors: Kishor L
authors: KL
authors: Handore
authors: D Srinivasa
authors: DS
authors: Reddy
mesh_terms: D000818:Animals; D015394:Molecular Structure; D032383:Myocytes, Cardiac / Q000187:drug effects*; D032404:Nardostachys / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: D012717:Sesquiterpenes; C581893:nardoaristolone B