title: Efficient synthesis of functionalized spiro[indoline-3,4'-pyrrolo[3,4-b]pyridines] via one-pot three-component reaction.
abstract: Diverse functionalized spiro[indoline-3,4'-pyrrolo[3,4-b]pyridines] were efficiently synthesized by the three-component reaction of 3-arylamino-1-methyl-H-pyrrole-2,5-dione, isatins and malononitrile (ethyl cyanoacetate) in ethanol in the presence of triethylamine. This reaction not only provided a convenient synthetic method for the construction of a versatile spirooxindole system, but also access to reactive β-enaminone and its derivatives for organic and medical chemistry.
authors: College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou, 225002, China.
authors: Chao
authors: C
authors: Wang
authors: Yan-Hong
authors: YH
authors: Jiang
authors: Chao-Guo
authors: CG
authors: Yan
mesh_terms: D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis*
chemical_list: D013141:Spiro Compounds