title: Who gains? Genetic and neurophysiological correlates of BMI gain upon college entry in women.
abstract: The present investigation examined P3 event-related electroencephalographic potentials and a short and selected list of addiction-related candidate gene single nucleotide polymorphisms (SNPs) within 84 female students, aged 18-20 yrs. The students were assigned to groups defined by the presence versus absence of a positive body mass index (BMI) change from the pre-college physical exam to the current day. Analyses revealed significantly greater P3 latencies and reduced P3 amplitudes during a response inhibition task among students who exhibited a BMI gain. BMI gain was also significantly associated with a ANKK1 SNP previously implicated in substance dependence risk. In logistic regression analyses, P3 latencies at the frontal electrode and this ANKK1 genotype correctly classified 71.1% of the students into the BMI groups. The present findings suggest that heritable indicators of impaired response inhibition can differentiate students who may be on a path toward an overweight or obese body mass.
authors: University of Connecticut School of Medicine, Farmington, CT 06030-2103, USA. Electronic address: lbauer@uchc.edu.
authors: Lance O
authors: LO
authors: Bauer
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D005260:Female; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D009482:Neurophysiology; D009765:Obesity / Q000235:genetics* / Q000523:psychology*; D010865:Pilot Projects; D020641:Polymorphism, Single Nucleotide; D017346:Protein Serine-Threonine Kinases / Q000235:genetics; D013334:Students; D014495:Universities; D015430:Weight Gain; D055815:Young Adult
chemical_list: C489948:ANKK1 protein, human; D017346:Protein Serine-Threonine Kinases
keywords: ANKK1; BMI; Genetics; Response inhibition