title: Indole synthesis from N-allenyl-2-iodoanilines under mild conditions mediated by samarium(II) diiodide.
abstract: A novel method for indole skeleton synthesis under mild conditions mediated by samarium(ii) diiodide has been developed. The reaction of N-allenyl-2-iodoaniline derivatives with SmI2 in the presence of HMPA and i-PrOH at 0 °C afforded indole derivatives in high yields.
authors: Kyoto Pharmaceutical University, 1 Misasagi-Shichono, Yamashina, Kyoto 607-8412, Japan. yamasita@mb.kyoto-phu.ac.jp.
authors: Hiroki
authors: H
authors: Iwasaki
authors: Kenji
authors: K
authors: Suzuki
authors: Mitsunari
authors: M
authors: Yamane
authors: Shohei
authors: S
authors: Yoshida
authors: Naoto
authors: N
authors: Kojima
authors: Minoru
authors: M
authors: Ozeki
authors: Masayuki
authors: M
authors: Yamashita
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D002625:Chemistry, Organic / Q000379:methods*; D003500:Cyclization; D004583:Electrons; D006492:Hempa / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D007454:Iodides / Q000737:chemistry*; D008956:Models, Chemical; D015394:Molecular Structure; D012493:Samarium / Q000737:chemistry*; D013696:Temperature
chemical_list: C552400:2-iodobenzenamine; D000814:Aniline Compounds; D007211:Indoles; D007454:Iodides; D012493:Samarium; C409809:samarium diiodide; D006492:Hempa