title: Distribution of endocrine cells in the digestive tract of Alligator sinensis during the active and hibernating period.
abstract: The digestive tract is the largest endocrine organ in the body; the distribution pattern of endocrine cells varies with different pathological and physiological states. The aim of the present study was to investigate the distributed density of 5-hydroxytryptamine (5-HT), gastrin (GAS), somatostatin (SS) and vasoactive intestinal peptide (VIP) immunoreactive (IR) cells in the digestive tract of Alligator sinensis during the active and hibernating period by immunohistochemical (IHC) method. The results indicated that 5-HT-IR cells were distributed throughout the entire digestive tract, which were most predominant in duodenum and jejunum. The density increased significantly in stomach and duodenum during hibernation. GAS-IR cells were limited in small stomach and small intestine. The density decreased significantly in small stomach during hibernation, while increased in duodenum. What's more, most of the endocrine cells in duodenum were generally spindle shaped with long cytoplasmic processes ending in the lumen during hibernation. SS-IR cells were limited in stomach and small stomach. The density increased in stomach while decreased in small stomach during hibernation, meanwhile, fewer IR cells occurred in small intestine. VIP-IR cells occurred in stomach and small stomach. The density decreased in small stomach, while increased in stomach during hibernation. These results indicated that the endocrine cells in different parts of digestive tract varied differently during hibernation, their changes were adaptive response to the hibernation.
authors: Key Laboratory for Conservation and Use of Important Biological Resources of Anhui Province, College of Life Sciences, Anhui Normal University, Wuhu, Anhui Province 241000, People's Republic of China.
authors: Huan
authors: H
authors: Wang
authors: Key Laboratory for Conservation and Use of Important Biological Resources of Anhui Province, College of Life Sciences, Anhui Normal University, Wuhu, Anhui Province 241000, People's Republic of China. Electronic address: szzhang@mail.ahnu.edu.cn.
authors: Shengzhou
authors: S
authors: Zhang
authors: Key Laboratory for Conservation and Use of Important Biological Resources of Anhui Province, College of Life Sciences, Anhui Normal University, Wuhu, Anhui Province 241000, People's Republic of China.
authors: Naizhen
authors: N
authors: Zhou
authors: Alligator Research Center of Anhui Province, Xuanzhou 242000, People's Republic of China.
authors: Chaolin
authors: C
authors: Wang
authors: Key Laboratory for Conservation and Use of Important Biological Resources of Anhui Province, College of Life Sciences, Anhui Normal University, Wuhu, Anhui Province 241000, People's Republic of China.
authors: Xiaobing
authors: X
authors: Wu
mesh_terms: D000489:Alligators and Crocodiles / Q000033:anatomy & histology* / Q000502:physiology*; D000818:Animals; D019858:Enteroendocrine Cells / Q000166:cytology*; D006605:Hibernation; D007150:Immunohistochemistry
keywords: Alligator sinensis; Digestive tract; Endocrine cells; Hibernation; Immunohistochemical