title: Mitochondrial dynamics and the innate antiviral immune response.
abstract: The innate immune system has a key role in the mammalian immune response. In the cytosol, RNA viruses are sensed by the retinoic acid-inducible gene-I-like receptors, which trigger a complex signaling cascade in which mitochondrial antiviral signaling protein plays a central role in mediating the innate host response through the induction of antiviral and inflammatory responses. Hence, the mitochondrion is now emerging as a fundamental hub for innate antiviral immunity beyond its known roles in metabolic processes and the control of programmed cell death. This review summarizes the findings related to mitochondrial antiviral signaling protein, and mitochondria and their dynamics, in the innate immune response to RNA viruses.
authors: INSERM UMR_S 1014, Hôpital Paul Brousse, Villejuif, France; Université Paris-Sud P11, Orsay, France; Equipe Labellisée Ligue contre le Cancer, Villejuif, France.
authors: Marie
authors: M
authors: Pourcelot
authors: Damien
authors: D
authors: Arnoult
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology; D000818:Animals; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases / Q000502:physiology; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D063154:Mitochondrial Dynamics; D012328:RNA Viruses / Q000276:immunology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D011971:Receptors, Immunologic; D015398:Signal Transduction / Q000276:immunology*; D051193:Toll-Like Receptors / Q000502:physiology
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C505371:MAVS protein, human; D017382:Reactive Oxygen Species; D011971:Receptors, Immunologic; D051193:Toll-Like Receptors; C452820:RIGI protein, human; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases
keywords: innate immunity; mitochondria; mitochondrial antiviral signaling protein; mitochondrial dynamics; retinoic acid-inducible gene-I (RIG-I)-like receptors