title: Fat mass and obesity-associated gene rs11642015 polymorphism is significantly associated with prediabetes and type 2 diabetes subsequent to adjustment for body mass index.
abstract: The association of the fat mass and obesity-associated gene (FTO) rs11642015 polymorphism with prediabetes, type 2 diabetes and obesity in certain populations has not been previously reported. A population-based study was conducted that included 490 type 2 diabetic, 471 prediabetic and 575 normal subjects. The main outcomes of the study were prediabetes, type 2 diabetes and obesity. Binary logistic regression was performed to estimate the association ofFTOrs11642015 with the risk of prediabetes, type 2 diabetes and obesity following adjustment for the corresponding confounders. A meta-analysis was also conducted to evaluate the association betweenFTOrs11642015 and obesity.FTOrs11642015 was significantly associated with prediabetes in the whole sample under the additive model [odds ratio (OR), 1.50; 95% confidence interval (CI), 1.17-1.93; P=0.002], particularly in females. The polymorphism remained consistently significant following adjustment for age and body mass index (BMI), showing an increased prediabetes risk with an additive effect (OR, 1.55; 95% CI, 1.19-2.01; P=0.001). In addition, a significant association was found for rs11642015 with prediabetes and type 2 diabetes under the dominant model. However, under the stringent Bonferroni's correction there was no evidence of positive associations forFTOrs11642015 with obesity in the whole sample, females or males. Findings of the meta-analysis showed thatFTOrs11642015 was not predisposed to obesity. In conclusion, the T allele ofFTOrs11642015 is positively associated with an increased risk of prediabetes, even after adjustment for age and BMI, particularly in females. Subjects carrying the CT + TT genotype are predisposed to prediabetes and type 2 diabetes. Therefore, results of the population-based study and follow-up meta-analysis suggested thatFTOrs11642015 is not significantly associated with susceptibility to obesity.
authors: Zhejiang Provincial Key Laboratory of Pathophysiology, Diabetes Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors: Liyuan
authors: L
authors: Han
authors: Zhejiang Provincial Key Laboratory of Pathophysiology, Diabetes Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors: Linlin
authors: L
authors: Tang
authors: Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, Guangdong 518054, P.R. China.
authors: Changyi
authors: C
authors: Wang
authors: Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, Guangdong 518054, P.R. China.
authors: Zhongwei
authors: Z
authors: Chen
authors: Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, Guangdong 518054, P.R. China.
authors: Tao
authors: T
authors: Zhang
authors: Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, Guangdong 518054, P.R. China.
authors: Sihan
authors: S
authors: Chen
authors: Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, Guangdong 518054, P.R. China.
authors: Shengyuan
authors: S
authors: Liu
authors: Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, Guangdong 518054, P.R. China.
authors: Xiaolin
authors: X
authors: Peng
authors: The Affiliated Hospital, School of Medicine, Ningbo University, Ningbo, Zhejiang 315000, P.R. China.
authors: Yifeng
authors: Y
authors: Mai
authors: Zhejiang Provincial Key Laboratory of Pathophysiology, Diabetes Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors: Shiwei
authors: S
authors: Duan
keywords: body mass index; fat mass and obesity-associated gene; prediabetes; rs11642015; type 2 diabetes