title: Delineation of hippocampal subregions using T1-weighted magnetic resonance images at 3 Tesla.
abstract: Although several novel approaches for hippocampal subregion delineation have been developed, they need to be applied prospectively and may be limited by long scan times, the use of high field (>3T) imaging systems, and limited reliability metrics. Moreover, the majority of MR imaging data collected to date has employed a T1-weighted acquisition, creating a critical need for an approach that provides reliable hippocampal subregion segmentation using such a contrast. We present a highly reliable approach for the identification of six subregions comprising the hippocampal formation from MR images including the subiculum, dentate gyrus/cornu Ammonis 4 (DG/CA4), entorhinal cortex, fimbria, and anterior and posterior segments of cornu Ammonis 1-3 (CA1-3). MR images were obtained in the coronal plane using a standard 3D spoiled gradient sequence acquired on a GE 3T scanner through the whole head in approximately 10 min. The average ICC for inter-rater reliability across right and left volumetric regions-of-interest was 0.85 (range 0.71-0.98, median 0.86) and the average ICC for intra-rater reliability was 0.92 (range 0.66-0.99, median 0.97). The mean Dice index for inter-rater reliability across right and left hemisphere subregions was 0.75 (range 0.70-0.81, median 0.75) and the mean Dice index for intra-rater reliability was 0.85 (range 0.82-0.90, median 0.85). An investigation of hippocampal asymmetry revealed significantly greater right compared to left hemisphere volumes in the anterior segment of CA1-3 and in the subiculum.
authors: Center for Psychiatric Neuroscience, The Feinstein Institute for Medical Research, Manhasset, NY, USA. kathryn.rhindress09@stjohns.edu.|Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-LIJ Health System, 75-59 263rd Street, Glen Oaks, NY, 11004, USA. kathryn.rhindress09@stjohns.edu.|Department of Psychology, St. John's University, Queens, NY, USA. kathryn.rhindress09@stjohns.edu.
authors: Kathryn
authors: K
authors: Rhindress
authors: Department of Communication Sciences and Disorders, University of Mississippi, Oxford, MS, USA.
authors: Toshikazu
authors: T
authors: Ikuta
authors: Department of Psychology, St. John's University, Queens, NY, USA.
authors: Robin
authors: R
authors: Wellington
authors: Center for Psychiatric Neuroscience, The Feinstein Institute for Medical Research, Manhasset, NY, USA.|Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-LIJ Health System, 75-59 263rd Street, Glen Oaks, NY, 11004, USA.|Department of Psychiatry and Department of Molecular Medicine, Hofstra North Shore - LIJ School of Medicine, Hempstead, NY, USA.
authors: Anil K
authors: AK
authors: Malhotra
authors: Center for Psychiatric Neuroscience, The Feinstein Institute for Medical Research, Manhasset, NY, USA.|Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-LIJ Health System, 75-59 263rd Street, Glen Oaks, NY, 11004, USA.|Department of Psychiatry and Department of Molecular Medicine, Hofstra North Shore - LIJ School of Medicine, Hempstead, NY, USA.
authors: Philip R
authors: PR
authors: Szeszko
mesh_terms: D000328:Adult; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D005260:Female; D006624:Hippocampus / Q000033:anatomy & histology* / Q000473:pathology / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008297:Male; D015203:Reproducibility of Results
keywords: 3 Tesla; Delineation criteria; Hippocampus; Magnetic resonance imaging; Subregion