title: Tunable T1 and T2 contrast abilities of manganese-engineered iron oxide nanoparticles through size control.
abstract: In this paper, we demonstrate the tunable T1 and T2 contrast abilities of engineered iron oxide nanoparticles with high performance for liver contrast-enhanced magnetic resonance imaging (MRI) in mice. To enhance the diagnostic accuracy of MRI, large numbers of contrast agents with T1 or T2 contrast ability have been widely explored. The comprehensive investigation of high-performance MRI contrast agents with controllable T1 and T2 contrast abilities is of high importance in the field of molecular imaging. In this study, we synthesized uniform manganese-doped iron oxide (MnIO) nanoparticles with controllable size from 5 to 12 nm and comprehensively investigated their MRI contrast abilities. We revealed that the MRI contrast effects of MnIO nanoparticles are highly size-dependent. By controlling the size of MnIO nanoparticles, we can achieve T1-dominated, T2-dominated, and T1-T2 dual-mode MRI contrast agents with much higher contrast enhancement than the corresponding conventional iron oxide nanoparticles.
authors: State Key Laboratory of Physical Chemistry of Solid Surfaces, The Key Laboratory for Chemical Biology of Fujian Province and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China. jhgao@xmu.edu.cn.
authors: Guoming
authors: G
authors: Huang
authors: Hui
authors: H
authors: Li
authors: Jiahe
authors: J
authors: Chen
authors: Zhenghuan
authors: Z
authors: Zhao
authors: Lijiao
authors: L
authors: Yang
authors: Xiaoqin
authors: X
authors: Chi
authors: Zhong
authors: Z
authors: Chen
authors: Xiaomin
authors: X
authors: Wang
authors: Jinhao
authors: J
authors: Gao
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000138:chemical synthesis; D007089:Image Enhancement / Q000379:methods*; D008099:Liver / Q000033:anatomy & histology*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D008345:Manganese / Q000737:chemistry; D008422:Materials Testing; D051379:Mice; D008807:Mice, Inbred BALB C; D010316:Particle Size; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013499:Surface Properties
chemical_list: D003287:Contrast Media; D058185:Magnetite Nanoparticles; D008345:Manganese