title: [The role of changes in the subfractional compound of tear fluid in the assessment of damaging effect from soft contact lenses and the excimer laser ablation of the cornea].
abstract: The method of laser correlation spectroscopy (LCS) was used for the examination of the subfractional compound of tear fluid in patients who have been using soft contact lens (SCL) for a long period and before and after the excimer laser correction with transepithelial photorefractive keratectomy (Trans PRK). Based on the analysis of biological material of 141 patients aged from 18 to 33 years old, we can conclude that prolonged usage of SCL leads to catabolic processes in surface of the anterior segment of the eye and, as a result, to changes in the qualitative composition of the tear fluid. The amount of low molecular weight fractions and medium weight ingredients increases after transepithelial photorefractive keratectomy, which can characterize reparation processes after cornea ablation. Based on the results of our study we can conclude that LCS--is express analysis, with which we can diagnose and observe the initial changes in local metabolism in the anterior segment of the eye, when the objective breaches have not seen yet.
authors: M A
authors: MA
authors: Stepanova
authors: E N
authors: EN
authors: Arkhipova
authors: Yu S
authors: YS
authors: Medvedeva
authors: M Yu
authors: MY
authors: Karganov
authors: E N
authors: EN
authors: Eskina
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D003263:Contact Lenses, Hydrophilic / Q000009:adverse effects*; D003315:Cornea / Q000473:pathology* / Q000601:surgery; D065306:Corneal Injuries; D005260:Female; D006801:Humans; D049008:Keratectomy, Subepithelial, Laser-Assisted / Q000009:adverse effects*; D054018:Lasers, Excimer; D008297:Male; D018903:Photorefractive Keratectomy / Q000009:adverse effects*; D011183:Postoperative Complications / Q000175:diagnosis; D013666:Tears / Q000737:chemistry*