title: Factors affecting response to biologic treatment in psoriasis.
abstract: Psoriasis is a chronic, immune-mediated inflammatory skin disease, affecting approximately 2-4% of the population in western countries. Patients with a more severe form of the disease are typically considered for systemic therapy, including biologics. In spite of the overall superiority of biologic agents, the treatment response may differ substantially among individual patients. As with other medical conditions, a range of factors contribute to response heterogeneity observed in psoriasis. Proper identification of these factors can significantly improve the therapeutic decisions. This review focuses on potential genetic and nongenetic factors that may affect the treatment response and outcomes in patients with psoriasis.
authors: Poznan University of Medical Sciences, Poznan, Poland.
authors: Jacek
authors: J
authors: Karczewski
authors: Barbara
authors: B
authors: Poniedziałek
authors: Piotr
authors: P
authors: Rzymski
authors: Zygmunt
authors: Z
authors: Adamski
mesh_terms: D001688:Biological Products / Q000009:adverse effects / Q000627:therapeutic use*; D020022:Genetic Predisposition to Disease; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D018579:Patient Selection; D010641:Phenotype; D011565:Psoriasis / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D001688:Biological Products; D007166:Immunosuppressive Agents
keywords: biologic agent; psoriasis; treatment predictor; treatment response