title: Clinical and biological acceptance of a fibrocollagen-coated mersylene patch for tracheal repair in growing dogs.
abstract: BACKGROUND
  Collagen-covered prostheses can be used as a non-circumferential segmental tracheal replacement. However, the applicability of these implants in young subjects has not yet been reported.
  
  
  METHODS
  In this experimental, longitudinal study, dogs aged 29-32 days underwent limited segmental tracheal replacement with a polyester prosthesis or were allocated to a control, untreated group. The dogs were evaluated clinically, endoscopically and tomographically for up to one year.
  
  
  RESULTS
  Although there was evidence of tracheal growth in the experimental group, tomographic measurements were significantly smaller in this group than in the control group throughout the observation period. At the end of the study, there was no evidence of implant rejection, stenosis or collapse. Normal respiratory epithelium had grown across the implanted membrane in the experimental group.
  
  
  CONCLUSIONS
  The homologous collagen mersylene membrane allowed for limited structural tracheal growth and was functionally integrated into the segmented tracheal wall in growing dogs.
authors: Laboratorio de Cirugía Experimental,Instituto Nacional de Pediatría,Mexico City,Mexico.
authors: F
authors: F
authors: Villegas-Alvarez
authors: Laboratorio de Cirugía Experimental,Instituto Nacional de Pediatría,Mexico City,Mexico.
authors: B
authors: B
authors: Pérez-Guillé
authors: Laboratorio de Cirugía Experimental,Instituto Nacional de Pediatría,Mexico City,Mexico.
authors: R E
authors: RE
authors: Soriano-Rosales
authors: Laboratorio de Cirugía Experimental,Instituto Nacional de Pediatría,Mexico City,Mexico.
authors: M A
authors: MA
authors: Jiménez-Bravo-Luna
authors: Laboratorio de Microscopía Electrónica,Instituto Nacional de Pediatría,Mexico City,Mexico.
authors: A
authors: A
authors: Gonzalez-Maciel
authors: Departamento de Radiología,Instituto Nacional de Pediatría,Mexico City,Mexico.
authors: S L
authors: SL
authors: Elizalde-Velazquez
authors: Departamento de Cirugía,Facultad de Medicina,Universidad Nacional Autónoma de México,Mexico City,Mexico.
authors: R
authors: R
authors: Aguirre-Hernández
authors: Laboratorio de Microscopía Electrónica,Instituto Nacional de Pediatría,Mexico City,Mexico.
authors: A
authors: A
authors: Ramos-Morales
authors: Laboratorio de Microscopía Electrónica,Instituto Nacional de Pediatría,Mexico City,Mexico.
authors: R
authors: R
authors: Reynoso-Robles
authors: Laboratorio de Cirugía Experimental,Instituto Nacional de Pediatría,Mexico City,Mexico.
authors: J F
authors: JF
authors: González-Zamora
mesh_terms: D000818:Animals; D020099:Coated Materials, Biocompatible; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D007828:Laryngoscopy; D008297:Male; D061330:Multidetector Computed Tomography; D019736:Prostheses and Implants; D011474:Prosthesis Design; D019651:Plastic Surgery Procedures / Q000379:methods*; D014132:Trachea / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D014133:Tracheal Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*
chemical_list: D020099:Coated Materials, Biocompatible