title: Natural killer T cell strategies to combat Epstein-Barr virus infection.
abstract: Epstein-Barr virus (EBV) infection results in rapid loss of CD1d expression from the surface of infected B cells, thus enabling the virus to evade immune recognition by natural killer T (NKT) cells. Using pharmacologic means to boost CD1d expression, potent NKT cell effector functions can be elicited toward EBV-infected B cells, suggesting the promise of novel strategies to target EBV-associated diseases such as some B-cell malignancies.
authors: Child and Family Research Institute; Immunity in Health and Disease; University of British Columbia; Vancouver, BC Canada ; Department of Pathology and Laboratory Medicine; University of British Columbia; Vancouver, BC Canada.
authors: John J
authors: JJ
authors: Priatel
authors: Child and Family Research Institute; Immunity in Health and Disease; University of British Columbia; Vancouver, BC Canada ; Department of Medical Genetics; University of British Columbia; Vancouver, BC Canada.
authors: Brian K
authors: BK
authors: Chung
authors: Child and Family Research Institute; Immunity in Health and Disease; University of British Columbia; Vancouver, BC Canada ; Department of Pathology and Laboratory Medicine; University of British Columbia; Vancouver, BC Canada.
authors: Kevin
authors: K
authors: Tsai
authors: Child and Family Research Institute; Immunity in Health and Disease; University of British Columbia; Vancouver, BC Canada ; Department of Pathology and Laboratory Medicine; University of British Columbia; Vancouver, BC Canada ; Department of Pathology; Sidra Medical and Research Center; Doha, Qatar.
authors: Rusung
authors: R
authors: Tan
keywords: B cell lymphoma; Burkitt's lymphoma; CD1d; Epstein–Barr virus; NKT cells; X-linked lymphoproliferative disease; herpesvirus; immunodeficiency; infection; mononucleosis