title: Neuro-pharmacological effects of Crinum zeylanicum in mice.
abstract: OBJECTIVE
  The aim of present study was to evaluate some effects of Crinum zeylanicum (C. zeylanicum) on central nervous system.
  
  
  METHODS
  C. zeylanicum methanolic bulb extract (250-1000 mg/kg orally), 2 mg chlorpromazine and 4 mg diazepam /kg body weight intraperitoneally respectively were tested in mice using Irwin test, pentobarbitone-induced sleep test, spontaneous motor activity, apomorphine-induced stereotype behaviour, and rota-rod performance.
  
  
  RESULTS
  The C. zeylanicum bulb extract significantly and dose-dependently decreased apomorphine-induced hyperactivity in mice (p<0.001). The Irwin test revealed dose-dependent central depressant effect of the extract, shortened (p<0.05-0.01) the onset of sleep and prolonged the duration of sleep. The extract produced significant (p<0.05-0.001) and dose- dependent reduction in spontaneous motor activity and apomorphine-induced stereotype behaviours in mice. The extract had no effect on performance of mice on rotarod.
  
  
  CONCLUSIONS
  The results suggest that the extract may possess sedative principles with potential neuroleptic properties.
authors: Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development Idu industrial Area, Abuja, Nigeria.
authors: Adeniyi
authors: A
authors: Yahaya Tijani
authors: Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development Idu industrial Area, Abuja, Nigeria.
authors: Oluwakanyinsola
authors: O
authors: Adeola Salawu
authors: Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development Idu industrial Area, Abuja, Nigeria.
authors: Good-Luck
authors: GL
authors: Jaiyeoba
authors: Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria.
authors: Joseph
authors: J
authors: Akponso Anuka
authors: Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria.
authors: Isah
authors: I
authors: Marte Hussaini
keywords: Crinum Zeylanicum; Pentobarbitone; Psychosis; Sleep; Stereotype Behaviour