title: Intussusception following rotavirus vaccination: an updated review of the available evidence.
abstract: In 1999, the first rotavirus vaccine licensed in the USA was withdrawn 9 months after introduction due to an association with intussusception that was detected in post-licensure surveillance. This association prompted large clinical trials designed to ensure the safety of two current live oral rotavirus vaccines, RotaTeq and Rotarix, which have since been recommended for use worldwide. Following their introduction, post-licensure studies have focused not only on the effectiveness and impact of these vaccines, but also on continued surveillance for intussusception. Most recent evidence from several countries shows a small increased risk of intussusception following vaccination with Rotarix and RotaTeq within the context of their demonstrated benefits. This review summarizes the available data on the safety of rotavirus vaccines with regards to intussusception.
authors: Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, MS A-34 Atlanta, GA 30333, USA.
authors: Brian
authors: B
authors: Rha
authors: Jacqueline E
authors: JE
authors: Tate
authors: Eric
authors: E
authors: Weintraub
authors: Penina
authors: P
authors: Haber
authors: Catherine
authors: C
authors: Yen
authors: Manish
authors: M
authors: Patel
authors: Margaret M
authors: MM
authors: Cortese
authors: Frank
authors: F
authors: DeStefano
authors: Umesh D
authors: UD
authors: Parashar
mesh_terms: D006801:Humans; D007443:Intussusception / Q000139:chemically induced* / Q000453:epidemiology*; D022243:Rotavirus Vaccines / Q000008:administration & dosage / Q000009:adverse effects*; D014481:United States / Q000453:epidemiology; D014611:Vaccination / Q000009:adverse effects*; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: C492457:RIX4414 vaccine; C492535:RotaTeq; D022243:Rotavirus Vaccines; D014613:Vaccines, Attenuated
keywords: intussusception; rotavirus; rotavirus disease; rotavirus vaccine; safety; vaccines