title: [Derangements of mineral metabolism associated with tumors].
abstract: Bone as a hard tissue has several functions such as supporting our body and protecting internal organs. In addition, bone has a pivotal role in the regulation of circulatory mineral concentrations. Therefore, abnormal bone metabolism is sometimes accompanied by deranged serum calcium or phosphate levels as shown in patients with malignancy-associated hypercalcemia (MAH) or tumor-induced osteomalacia (TIO) . Parathyroid hormone-related protein, PTHrP, was cloned as a major humoral factor causing MAH. Similarly, fibroblast growth factor 23, FGF23, was identified as a causative factor for TIO. Therefore, MAH and TIO are not only important in clinical practice but also gave us deep insights into the mechanisms of mineral homeostasis, and bone and cartilage metabolism.
authors: Division of Nephrology & Endocrinology, Department of Medicine, University of Tokyo Hospital, Japan.
authors: Seiji
authors: S
authors: Fukumoto
mesh_terms: D000818:Animals; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D000089703:Fibroblast Growth Factor-23; D006801:Humans; D006934:Hypercalcemia / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism*; D010257:Paraneoplastic Syndromes / Q000378:metabolism; D044162:Parathyroid Hormone-Related Protein / Q000378:metabolism
chemical_list: C000717427:FGF23 protein, human; D044162:Parathyroid Hormone-Related Protein; D000089703:Fibroblast Growth Factor-23; D002118:Calcium