title: Fiber-assisted molding (FAM) of surfaces with tunable curvature to guide cell alignment and complex tissue architecture.
abstract: A simple and robust method termed "fiber-assisted molding (FAM)" is presented to create biomimetic three-dimensional surfaces with controllable curvature and helical twist. The alignment of muscle fibrils and the assembly of helically patterned extracellular matrix by cells demonstrate the potential of this method for tissue engineering and other materials science applications.
authors: Laboratory of Applied Mechanobiology, Department of Health Sciences and Technology, ETH Zurich, Vladimir-Prelog-Weg 1-5/10, CH-8093, Zurich, Switzerland.
authors: Vahid
authors: V
authors: Hosseini
authors: Philip
authors: P
authors: Kollmannsberger
authors: Samad
authors: S
authors: Ahadian
authors: Serge
authors: S
authors: Ostrovidov
authors: Hirokazu
authors: H
authors: Kaji
authors: Viola
authors: V
authors: Vogel
authors: Ali
authors: A
authors: Khademhosseini
mesh_terms: D040761:Biomimetic Materials; D032701:Biomimetics / Q000379:methods*; D004129:Dimethylpolysiloxanes / Q000737:chemistry; D005109:Extracellular Matrix; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D008422:Materials Testing; D010100:Oxygen / Q000737:chemistry; D013499:Surface Properties; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D004129:Dimethylpolysiloxanes; C013830:baysilon; D010100:Oxygen
keywords: cell alignment; curvature; fibers; microfabrication; tissue engineering