title: Monoterpene derivatives from the roots of Paeonia lactiflora and their anti-proliferative activity.
abstract: An unusual nor-monoterpene with only nine carbons, nor-paeonilactone (1), two new monoterpenes, paeonisuffrone C (2), paeonilactone D (9), and a new monoterpene glucoside, paeonin D (3), along with ten known compounds were isolated from the dried roots of Paeonia lactiflora. Their structures were elucidated on the basis of spectroscopic analysis, including 1D and 2D NMR, and computational data. Compounds 4-14 were evaluated for their anti-proliferative activities against BT 483 human breast cancer cells and OVCA 429 human ovarian cancer cells by MTT assay.
authors: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors: Pan
authors: P
authors: Li
authors: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors: Ze-Ming
authors: ZM
authors: Zhang
authors: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors: Tao
authors: T
authors: Li
authors: School of Chinese Medicine, LKS Faculty of Medicine, the University of Hong Kong, Pokfulam, Hong Kong.
authors: Yan-Bo
authors: YB
authors: Zhang
authors: School of Chinese Medicine, LKS Faculty of Medicine, the University of Hong Kong, Pokfulam, Hong Kong. Electronic address: stephen@hku.hk.
authors: Stephen Cho Wing
authors: SC
authors: Sze
authors: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China; School of Chinese Medicine, LKS Faculty of Medicine, the University of Hong Kong, Pokfulam, Hong Kong. Electronic address: twangguocai@jnu.edu.cn.
authors: Guo-Cai
authors: GC
authors: Wang
authors: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors: Yao-Lan
authors: YL
authors: Li
authors: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors: Wen-Cai
authors: WC
authors: Ye
mesh_terms: D000872:Anthocyanins / Q000737:chemistry* / Q000302:isolation & purification; D045744:Cell Line, Tumor; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification; D006801:Humans; D015394:Molecular Structure; D039821:Monoterpenes / Q000737:chemistry* / Q000302:isolation & purification; D029596:Paeonia / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*
chemical_list: D000872:Anthocyanins; D005960:Glucosides; D039821:Monoterpenes; C000597510:paeonilactone D; C419234:paeonisuffrone; C047592:paeonin
keywords: Anti-proliferative; Monoterpene; Paeonia lactiflora; Paeoniaceae