title: Telocytes in mice bone marrow: electron microscope evidence.
abstract: Telocytes (TCs) are a novel type of interstitial cell of whom presence has been recently documented in many tissues and organs. However, whether TCs exists in bone marrow is still not reported. This study aims to find out TCs in mice bone marrow by using scanning electron microscope (SEM) and transmission electron microscope (TEM). SEM images showed that in mice bone marrow most of TCs have small spherical cell body (usually 4-6 μm diameter) with thin long telopodes (Tps; usually one to three). The longest Tp observed was about 70 μm, with an uneven calibre. Direct intercellular contacts exist between TCs. TEM shows mitochondria within dilations of Tps. Also, by TEM, we show the close spatial relations of Tps with blood vessels. In conclusion, this study provides ultrastructural evidence regarding the existence of TCs in mice bone marrow, in situ.
authors: Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China; Department of Physiology and Medicine/Cardiology, University of California, Los Angeles, CA, USA.
authors: Hua
authors: H
authors: Li
authors: Hongqi
authors: H
authors: Zhang
authors: Lin
authors: L
authors: Yang
authors: Shanshan
authors: S
authors: Lu
authors: Junbo
authors: J
authors: Ge
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000648:ultrastructure*; D002478:Cells, Cultured; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008855:Microscopy, Electron, Scanning / Q000379:methods*; D046529:Microscopy, Electron, Transmission / Q000379:methods*; D008928:Mitochondria / Q000648:ultrastructure*
keywords: SEM; TEM; Telocyte; bone marrow; intercellular contacts; telopodes