title: [System analysis of metabolic profile of blood in patients with thermal trauma].
abstract: OBJECTIVE
  To make multiparametric analysis of blood metabolic profile in early period of burn disease.
  
  
  METHODS
  We tested blood samples of 15 healthy adults (control group) and 60 patients with thermal trauma (main group--II-4IIIA, B degree of burn, more then 15 bsp). Parameters of lipid metabolism, level of glucose, lactate, malonic dialdehyde and some enzymes in blood plasma and erythrocytes were estimated.
  
  
  RESULTS
  In early period of burn disease we fixed the clear metabolic disorders, including tissues hypoxia, activation of plasma transaminases and oxidoreductases, inhibition of detoxication system, induction of oxidative stress. Connection of metabolic changes, associated with burn disease, was registered. It supported by numerous correlations between studied parameters, formed from first day after trauma.
  
  
  CONCLUSIONS
  Our data expand the knowledge about mating metabolic changes of catalytic activity of blood enzymes, forming in early period of burn disease (system metabolic disadaptation), and diagnostic value of some blood biochemical parameters in estimation of burned patient metabolism.
authors: A G
authors: AG
authors: Solov'eva
authors: A K
authors: AK
authors: Martucevich
authors: S P
authors: SP
authors: Peretiagin
authors: N V
authors: NV
authors: Didenko
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001769:Blood / Q000378:metabolism*; D001786:Blood Glucose / Q000032:analysis; D002056:Burns / Q000097:blood* / Q000378:metabolism; D016022:Case-Control Studies; D003402:Creatine Kinase / Q000097:blood; D004798:Enzymes / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism; D006801:Humans; D019344:Lactic Acid / Q000097:blood; D050356:Lipid Metabolism; D008315:Malondialdehyde / Q000097:blood; D011237:Predictive Value of Tests; D000516:alpha-Amylases / Q000097:blood
chemical_list: D001786:Blood Glucose; D004798:Enzymes; D019344:Lactic Acid; D008315:Malondialdehyde; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003402:Creatine Kinase; D000516:alpha-Amylases