title: Trends in research of antitrypanosomal agents among synthetic heterocycles.
abstract: To date treatment of trypanosomiasis urgently requires new effective and non-toxic drugs. The article covers some of the achievements in the search for new antitrypanosomal agents; also the "validated" biological targets used in the antitrypanosomal agents design are outlined. The major part of the manuscript focuses on the synthetic small molecules, such as thiosemicarbazone and thiazole (as their cyclic analogues) derivatives, benzofuran derivatives, heterocycles bearing nitro group etc. Also, the attractiveness of metal complexes and well known drugs as sources for antitrypanosomal agent design is discussed.
authors: Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Ukraine, Pekarska 69, Lviv 79010, Ukraine.
authors: Anna
authors: A
authors: Kryshchyshyn
authors: Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Ukraine, Pekarska 69, Lviv 79010, Ukraine.
authors: Danylo
authors: D
authors: Kaminskyy
authors: National Museum of Natural History, UMR 7245 CNRS-MNHN, Team BAMEE, CP 52, 57 Rue Cuvier, 75005 Paris, France.
authors: Philippe
authors: P
authors: Grellier
authors: Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Ukraine, Pekarska 69, Lviv 79010, Ukraine. Electronic address: roman.lesyk@gmail.com.
authors: Roman
authors: R
authors: Lesyk
mesh_terms: D000818:Animals; D014355:Chagas Disease / Q000188:drug therapy; D055808:Drug Discovery / Q000379:methods* / Q000639:trends; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D014344:Trypanocidal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D006571:Heterocyclic Compounds; D014344:Trypanocidal Agents
keywords: Antitrypanosomal agents; Heterocyclic small molecules; Trypanosome targets