title: Hypoglycemic activity and acute oral toxicity of chromium methionine complexes in mice.
abstract: The hypoglycemic activity of chromium methionine (CrMet) in alloxan-induced diabetic (AID) mice was investigated and compared with those of chromium trichloride hexahydrate (CrCl3·6H2O) and chromium nicotinate (CrNic) through a 15-day feeding experiment. The acute oral toxicity of CrMet was also investigated in ICR (Institute for Cancer Research) mice by a single oral gavage. The anti-diabetic activity of CrMet was explored in detail from the aspects of body weight (BW), blood glucose, triglyceride, total cholesterol, liver glycogen levels, aspartate transaminase (AST) and alanine transaminase (ALT) levels. The obtained results showed that CrMet had beneficial effects on glucose and lipid metabolism, and might possess hepatoprotective efficacy for diabetes. Daily treatment with 500 and 1000μg Cr/kg BW of CrMet in AID mice for 15 days indicated that this low-molecular-weight organic chromium complex had better bioavailability and more beneficial effects on diabetics than CrCl3·6H2O. CrMet also had advantage over CrNic in the control of AST and ALT activities. Acute toxicity studies revealed that CrMet had low toxicity potential and relatively high safety margins in mice with the LD50 value higher than 10.0g/kg BW. These findings suggest that CrMet might be of potential value in the therapy and protection of diabetes.
authors: National Engineering Laboratory for Hydrometallurgical Cleaner Production Technology, Institute of Process Engineering, Beijing 100190, China; Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100190, China.
authors: Hai-yan
authors: HY
authors: Tang
authors: National Engineering Laboratory for Hydrometallurgical Cleaner Production Technology, Institute of Process Engineering, Beijing 100190, China; Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China. Electronic address: qgxiao@ipe.ac.cn.
authors: Qing-gui
authors: QG
authors: Xiao
authors: National Engineering Laboratory for Hydrometallurgical Cleaner Production Technology, Institute of Process Engineering, Beijing 100190, China; Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.
authors: Hong-bin
authors: HB
authors: Xu
authors: National Engineering Laboratory for Hydrometallurgical Cleaner Production Technology, Institute of Process Engineering, Beijing 100190, China; Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.
authors: Yi
authors: Y
authors: Zhang
mesh_terms: D000284:Administration, Oral; D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D002857:Chromium / Q000008:administration & dosage* / Q000633:toxicity*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000473:pathology; D006003:Glycogen / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008715:Methionine / Q000008:administration & dosage* / Q000633:toxicity*; D008813:Mice, Inbred ICR; D009929:Organ Size / Q000187:drug effects; D023382:Toxicity Tests, Acute; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D014280:Triglycerides; D002857:Chromium; D006003:Glycogen; D002784:Cholesterol; D008715:Methionine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
keywords: Acute oral toxicity; Chromium methionine; Hypoglycemic activity; Mice