title: Synthesis of Fe-Cu/TiO₂ nanostructure and its use in construction of a sensitive and selective sensor for metformin determination.
abstract: A carbon paste electrode modified with Fe-Cu/TiO2 was prepared and used for low level determination of metformin (MET) using square wave adsorptive stripping voltammetry (SWAdSV). The Fe-Cu/TiO2 nanoparticle was synthesized by a modified sol-gel method. The surface structure and composition of nanoparticles were characterized by scanning electron microscopy (SEM), X-ray powder diffraction analysis (XRD) and N2 physisorption. Also, electrochemical properties of the prepared nanocomposite modified electrode were investigated by cyclic voltammetry and electrochemical impedance spectroscopy (EIS) techniques. Under optimized conditions, the modified electrode exhibited a linear response over the concentration range of 15 nM to 75 μM MET, with a detection limit of 3 nM. The proposed sensor exhibited a high sensitivity, good selectivity and was successfully applied for MET determination in real samples such as human urine and pharmaceutical formulations.
authors: Department of Analytical Chemistry, Faculty of Chemistry, Razi University, Kermanshah, Iran. Electronic address: mbgholivand@yahoo.com.
authors: Mohammad Bagher
authors: MB
authors: Gholivand
authors: Department of Analytical Chemistry, Faculty of Chemistry, Razi University, Kermanshah, Iran.
authors: Mojtaba
authors: M
authors: Shamsipur
authors: Department of Analytical Chemistry, Faculty of Chemistry, Razi University, Kermanshah, Iran.
authors: Giti
authors: G
authors: Paimard
authors: Department of Analytical Chemistry, Faculty of Chemistry, Razi University, Kermanshah, Iran.
authors: Mostafa
authors: M
authors: Feyzi
authors: Department of Analytical Chemistry, Faculty of Chemistry, Razi University, Kermanshah, Iran.
authors: Fataneh
authors: F
authors: Jafari
mesh_terms: D000328:Adult; D003300:Copper / Q000737:chemistry*; D055664:Electrochemical Techniques / Q000295:instrumentation* / Q000379:methods; D004566:Electrodes; D006801:Humans; D007501:Iron / Q000737:chemistry*; D057230:Limit of Detection; D008687:Metformin / Q000032:analysis* / Q000652:urine; D053761:Nanocomposites / Q000737:chemistry*; D015203:Reproducibility of Results; D014025:Titanium / Q000737:chemistry*
chemical_list: C009495:titanium dioxide; D003300:Copper; D008687:Metformin; D014025:Titanium; D007501:Iron
keywords: Carbon paste modified electrode; Fe-Cu/TiO(2) nanoparticle; Metformin; Square wave adsorptive stripping voltammetry