title: Placental expression of the obesity-associated gene FTO is reduced by fetal growth restriction but not by macrosomia in rats and humans.
abstract: Genetic variants in the FTO (fat mass- and obesity-associated) gene have the highest association of all obesity-associated genes. Its placental expression was shown to relate to birth weight, suggesting that it may participate in the control of fetal weight gain. To gain more insight into the implication of FTO in fetal growth, we measured its placental expression in samples including extremes of abnormal fetal growth, such as after intrauterine growth restriction (IUGR) or macrosomia in both rats and humans. In rats, fetal growth was modulated by maternal nutritional modifications. In humans, placental villi were collected from pathological pregnancies (i.e. with IUGR or fetal macrosomia). Placental FTO mRNA expression was reduced by IUGR but was not significantly affected by macrosomia in either rats or humans. Our data suggest that placental FTO may participate in interactions between the in utero environment and the control of fetal growth under IUGR conditions by modulating epigenetic processes.
authors: 1 Univ Lille Nord de France, Unité Environnement Périnatal et Croissance, EA 4489, Université de Lille 1, Villeneuve d'Ascq, France.
authors: S
authors: S
authors: Mayeur
authors: 1 Univ Lille Nord de France, Unité Environnement Périnatal et Croissance, EA 4489, Université de Lille 1, Villeneuve d'Ascq, France.
authors: O
authors: O
authors: Cisse
authors: 2 Biologie du Développement et Reproduction, UMR INRA-ENVA-CNRS Jouy en Josas, France.
authors: A
authors: A
authors: Gabory
authors: 3 Institut Cochin, Univ Paris Descartes, CNRS, UMR 8104; INSERM U 1016, Paris, France.
authors: S
authors: S
authors: Barbaux
authors: 3 Institut Cochin, Univ Paris Descartes, CNRS, UMR 8104; INSERM U 1016, Paris, France.
authors: D
authors: D
authors: Vaiman
authors: 1 Univ Lille Nord de France, Unité Environnement Périnatal et Croissance, EA 4489, Université de Lille 1, Villeneuve d'Ascq, France.
authors: A
authors: A
authors: Vambergue
authors: 1 Univ Lille Nord de France, Unité Environnement Périnatal et Croissance, EA 4489, Université de Lille 1, Villeneuve d'Ascq, France.
authors: I
authors: I
authors: Fajardy
authors: 1 Univ Lille Nord de France, Unité Environnement Périnatal et Croissance, EA 4489, Université de Lille 1, Villeneuve d'Ascq, France.
authors: S
authors: S
authors: Deloof
authors: 2 Biologie du Développement et Reproduction, UMR INRA-ENVA-CNRS Jouy en Josas, France.
authors: C
authors: C
authors: Junien
authors: 1 Univ Lille Nord de France, Unité Environnement Périnatal et Croissance, EA 4489, Université de Lille 1, Villeneuve d'Ascq, France.
authors: C
authors: C
authors: Laborie
authors: 1 Univ Lille Nord de France, Unité Environnement Périnatal et Croissance, EA 4489, Université de Lille 1, Villeneuve d'Ascq, France.
authors: D
authors: D
authors: Vieau
authors: 1 Univ Lille Nord de France, Unité Environnement Périnatal et Croissance, EA 4489, Université de Lille 1, Villeneuve d'Ascq, France.
authors: J
authors: J
authors: Lesage