title: Molecular prognostic factors in glioblastoma: state of the art and future challenges.
abstract: Gliomas account for the majority of primary tumors of the CNS, of which glioblastoma (GBM) is the most common and malignant, and for which survival is very poor. Despite significant inter- and intra-tumor heterogeneity, all patients are treated with a standardized therapeutic approach. While some clinical features of GBM patients have already been established as classic prognostic factors (e.g., patient age at diagnosis and Karnofsky performance status), one of the most important research fields in neuro-oncology today is the identification of novel molecular determinants of patient survival and tumor response to therapy. Here, we aim to review and discuss some of the most relevant and novel prognostic biomarkers in adult and pediatric GBM patients that may aid in stratifying subgroups of GBMs and rationalizing treatment decisions.
authors: Life & Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal.
authors: Ana
authors: A
authors: Xavier-Magalhães
authors: Meera
authors: M
authors: Nandhabalan
authors: Chris
authors: C
authors: Jones
authors: Bruno M
authors: BM
authors: Costa
mesh_terms: D014408:Biomarkers, Tumor; D016543:Central Nervous System Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism*; D005909:Glioblastoma / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor