title: Correlation of serum adiponectin and adiponectin gene polymorphism with metabolic syndrome in Chinese adolescents.
abstract: OBJECTIVE
  To investigate the association of adiponectin and its gene polymorphisms with metabolic syndrome (MetS) and cardiovascular disease (CVD) risk factors in Chinese adolescents.
  
  
  METHODS
  This cross-sectional study enrolled 919 healthy middle school students (aged 11-16 years; 46.7% females). All participants underwent anthropometric and biochemical examinations, and MetS was diagnosed using 2007 International Diabetes Federation criteria. The presence of adiponectin and its genotypes of single nucleotide polymorphisms (SNPs) rs266729 (-11377C/G), rs2241766 (+45T/G) and rs1501299 (+276G/T) was detected.
  
  
  RESULTS
  (1) Serum adiponectin levels were negatively correlated with numerous CVD risk factors (all P<0.05), and following adjustments for confounding factors, a lower adiponectin level was an independent risk factor for MetS (odds ratio=5.59; 95% confidence interval: 1.90, 16.41). Central obesity and low levels of high-density lipoprotein cholesterol were positively associated with MetS and reduced serum adiponectin levels. (2) The genotype and frequencies of SNP-11377 and SNP+276 in a MetS group and non-MetS group were not significantly different. Subjects with genotype SNP+45 GG were at higher risk for MetS compared with subjects with genotypes SNP+45 TT (P=0.033) or TT+TG (P=0.021). Subjects with genotype SNP+276 TT or TT+TG had higher levels of serum adiponectin compared with subjects with SNP+276 GG (P=0.012 and 0.014, respectively).
  
  
  CONCLUSIONS
  Adiponectin may be used as a predictive biomarker of MetS, and shows a significant association with CVD risk factors in Chinese adolescents. Adiponectin gene polymorphisms are associated with serum adiponectin concentrations and the presence of MetS.
authors: Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, PR China.
authors: P
authors: P
authors: Li
authors: Liaoyang Diabetes Hospital, Liaoyang, PR China.
authors: R
authors: R
authors: Jiang
authors: 1] Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, PR China [2] The Liaoning Provincial Key Laboratory of Endocrine Diseases, Shenyang, PR China.
authors: L
authors: L
authors: Li
authors: Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, PR China.
authors: C
authors: C
authors: Liu
authors: Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, PR China.
authors: F
authors: F
authors: Yang
authors: Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, PR China.
authors: Y
authors: Y
authors: Qiu
mesh_terms: D052242:Adiponectin / Q000097:blood* / Q000235:genetics*; D000293:Adolescent; D002318:Cardiovascular Diseases / Q000097:blood; D002648:Child; D002681:China; D003430:Cross-Sectional Studies; D005260:Female; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000235:genetics*; D009765:Obesity / Q000097:blood; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
chemical_list: D052242:Adiponectin; D008055:Lipids