title: Recurrent native and prosthetic mitral valve thrombosis in idiopathic hypereosinophilic syndrome.
abstract: Hypereosinophilic syndrome (HES) is defined as a prolonged, unexplained peripheral eosinophilia. Endomyocardial fibrosis and mural thrombus formation are common occurrences such that patients are exposed to lethal thromboembolic complications. The valvular damage described is mainly related to iterative valve thromboses that are amenable to surgery. Here, the case is reported of a 39-year-old woman suffering from HES with mitral valve thrombosis and mechanical prosthetic mitral valve replacement, in whom a new thrombosis of the inserted prosthesis occurred one month postoperatively, concomitant with severe hypereosinophilia and despite adequate anticoagulation. The patient had received a new bioprosthetic mitral valve replacement, and her eosinophil count had been normalized after treatment with corticosteroids. Oral anticoagulation with warfarin was maintained. Subsequently, no recurrent thromboembolic events were reported, and echocardiography performed at the one-year follow up showed the bioprosthesis to have a normal hemodynamic profile.
authors: Lilia
authors: L
authors: Zakhama
authors: Iskander
authors: I
authors: Slama
authors: Elhem
authors: E
authors: Boussabah
authors: Basma
authors: B
authors: Harbegue
authors: Majdi
authors: M
authors: Mimouni
authors: Nabil
authors: N
authors: Abdelaali
authors: Sana
authors: S
authors: Sioua
authors: Moez
authors: M
authors: Thameur
authors: Soraya
authors: S
authors: Benyoussef
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D020878:Device Removal; D005260:Female; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects / Q000295:instrumentation*; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008946:Mitral Valve Stenosis / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D011474:Prosthesis Design; D011475:Prosthesis Failure; D012008:Recurrence; D012086:Reoperation; D013927:Thrombosis / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000925:Anticoagulants