title: Medulloblastoma treatment in a child on dialysis.
abstract: Managing patients who suffer from both cancer and end-stage renal disease is challenging because there is a paucity of data, especially for children. There are no published reports of adjuvant chemotherapy for medulloblastoma being used in children on dialysis. In this article we describe the case of an Italian 5-year-old boy on hemodialysis for chronic renal failure who presented with a desmoplastic medulloblastoma with extensive nodularity and nuclear β-catenin expression. The patient was treated with craniospinal irradiation after complete surgical resection, followed by six cycles of cyclophosphamide and vincristine. Vincristine was administered at the usual dosage for children with normal kidney function, cyclophosphamide was delivered after dialysis and over the course of the following day, starting with 50% of the commonly used dosage. This is the first case report of chemotherapy given during hemodialysis in a child with medulloblastoma. This treatment proved easy to administer despite the child's kidney disease and it maintained disease remission with no additional toxicity.
authors: Pediatrics Unit, Fondazione IRCCS, Istituto Nazionale Tumori, Via Giacomo Venezian 1, 20133 Milan, Italy.
authors: Nadia
authors: N
authors: Puma
authors: Veronica
authors: V
authors: Biassoni
authors: Lorenza
authors: L
authors: Gandola
authors: Emilia
authors: E
authors: Pecori
authors: Gianluigi
authors: G
authors: Ardissino
authors: Fabio
authors: F
authors: Paglialonga
authors: Alice
authors: A
authors: Indini
authors: Manila
authors: M
authors: Antonelli
authors: Maura
authors: M
authors: Massimino
mesh_terms: D002528:Cerebellar Neoplasms / Q000628:therapy*; D002675:Child, Preschool; D003956:Dialysis / Q000379:methods*; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000628:therapy*