title: A whiter shade of gray: HIF and coordination of angiogenesis with postnatal myelination.
abstract: Oligodendrocyte precursor cells are the primary source of myelinating oligodendrocytes in the neonatal CNS. In a recent issue of Cell, Yuen and coworkers (2014) show that hypoxia-inducible factors and Wnt7a/7b act in developing white matter, promoting angiogenesis in anticipation of the metabolic demands of oligogenesis, before finally allowing precursor differentiation.
authors: Physiological Laboratory, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK.
authors: Jingwei
authors: J
authors: Sim
authors: Physiological Laboratory, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK. Electronic address: rsj33@cam.ac.uk.
authors: Randall S
authors: RS
authors: Johnson
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism*; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism*; D009186:Myelin Sheath / Q000378:metabolism*; D009836:Oligodendroglia / Q000378:metabolism*; D000099162:Endothelial PAS Domain-Containing Protein 1
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D000099162:Endothelial PAS Domain-Containing Protein 1; C497443:Hif1a protein, mouse