title: Association of urinary phenols with increased body weight measures and obesity in children and adolescents.
abstract: OBJECTIVE
  To examine the association of urinary levels of the environmental phenol pesticides 2,5-dichlorophenol, 2,4-dichlorophenol, and triclosan with body weight outcomes in children and adolescent participants in the National Health and Nutrition Examination Survey 2007-2010.
  
  
  METHODS
  We performed multivariate linear and multinomial logistic regressions to analyze the association of body mass index (BMI) z-score, waist circumference (WC), and obesity with urinary pesticide concentration in children and adolescents.
  
  
  RESULTS
  After adjustment for covariates, we found a statistically significant positive association (P < .05) between both 2,5-dichlorophenol and 2,4-dichlorophenol with BMI z-score, WC, and obesity in children and adolescents. After stratification by age, the significant associations remained only in adolescents (ages 12-19). No associations were found between triclosan and any of the body weight outcomes.
  
  
  CONCLUSIONS
  We found an association between dichlorophenols and increased body weight measures (BMI z-score, WC, and obesity) in adolescents. However, further studies, such as a longitudinal study, are needed to confirm and elucidate on our findings.
authors: Division of Toxicology and Human Health Sciences, Centers for Disease Control and Prevention, Agency for Toxic Substances and Disease Registry, Atlanta, GA.
authors: Melanie C
authors: MC
authors: Buser
authors: Division of Toxicology and Human Health Sciences, Centers for Disease Control and Prevention, Agency for Toxic Substances and Disease Registry, Atlanta, GA.
authors: H Edward
authors: HE
authors: Murray
authors: Division of Toxicology and Human Health Sciences, Centers for Disease Control and Prevention, Agency for Toxic Substances and Disease Registry, Atlanta, GA. Electronic address: fes6@cdc.gov.
authors: Franco
authors: F
authors: Scinicariello
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D001835:Body Weight; D002648:Child; D002733:Chlorophenols / Q000737:chemistry; D003367:Cotinine / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D009749:Nutrition Surveys; D063766:Pediatric Obesity / Q000652:urine*; D010575:Pesticides / Q000652:urine*; D019800:Phenol / Q000652:urine*; D014260:Triclosan / Q000737:chemistry; D014481:United States; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D002733:Chlorophenols; D010575:Pesticides; D019800:Phenol; C056892:2,5-dichlorophenol; D014260:Triclosan; D003367:Cotinine; C004762:2,4-dichlorophenol