title: Regional and national guideline recommendations for digital ano-rectal examination as a means for anal cancer screening in HIV positive men who have sex with men: a systematic review.
abstract: BACKGROUND
  Although anal cancer is common in HIV positive men who have sex with men, few centres offer systematic screening. Regular digital ano-rectal examination (DARE) is a type of screening that has been recommended by some experts. How widely this forms part of HIV management guidelines is unclear.
  
  
  METHODS
  The protocol was registered prospectively (CRD42013005188; http://www.crd.york.ac.uk/PROSPERO/). We systematically reviewed 121 regional and national HIV guidelines and searched for guidelines from http://hivinsite.ucsf.edu/global?page=cr-00-04#SauguidelineX, PubMed and Web of Science databases up to 5th August 2013 for recommendations of DARE as a means of anal cancer screening in HIV positive MSM. Guidelines were examined in detail if they were clinical guidelines, including both prevention and treatment protocols and were in English. Guidelines were excluded if they were restricted to limited areas (e.g. antiretroviral therapy only, children or pregnant women, strategies for prevention/testing). Information was extracted regarding recommendation of DARE as a screening method, the frequency of DARE recommended, target population for screening and the strength of evidence supporting this.
  
  
  RESULTS
  30 regional and national guidelines were included and examined in detail. Only 2 recommended DARE. The 'European AIDS Clinical Society Guidelines' recommends DARE every 1-3 years for HIV positive MSM whilst the 'US Guideline for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents' recommends an annual DARE for the HIV + population in general. None of these guidelines specify the age of commencing screening. In each case, the highest level of evidence supporting these two recommendations was expert opinion.
  
  
  CONCLUSIONS
  Few HIV guidelines discuss or recommend DARE as a means of anal cancer screening. Studies of the efficacy, acceptability and cost-effectiveness of DARE are needed to assess its role in anal cancer screening.
authors: Melbourne School of Population and Global Health, University of Melbourne, 580 Swanston Street, Carlton, Victoria 3053, Australia. j.ong@unimelb.edu.au.
authors: Jason J
authors: JJ
authors: Ong
authors: Marcus
authors: M
authors: Chen
authors: Andrew E
authors: AE
authors: Grulich
authors: Christopher K
authors: CK
authors: Fairley
mesh_terms: D001005:Anus Neoplasms / Q000150:complications / Q000175:diagnosis*; D003362:Cost-Benefit Analysis; D051517:Digital Rectal Examination / Q000191:economics / Q000706:statistics & numerical data; D055088:Early Detection of Cancer / Q000191:economics / Q000706:statistics & numerical data; D005060:Europe; D015658:HIV Infections / Q000150:complications* / Q000175:diagnosis; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D017410:Practice Guidelines as Topic; D012189:Retrospective Studies; D014481:United States