title: Ultrastructure and complex polar architecture of the human pathogen Campylobacter jejuni.
abstract: Campylobacter jejuni is one of the most successful food-borne human pathogens. Here we use electron cryotomography to explore the ultrastructure of C. jejuni cells in logarithmically growing cultures. This provides the first look at this pathogen in a near-native state at macromolecular resolution (~5 nm). We find a surprisingly complex polar architecture that includes ribosome exclusion zones, polyphosphate storage granules, extensive collar-shaped chemoreceptor arrays, and elaborate flagellar motors.
authors: Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E. California Blvd., Pasadena, California, 91125.
authors: Axel
authors: A
authors: Müller
authors: Morgan
authors: M
authors: Beeby
authors: Alasdair W
authors: AW
authors: McDowall
authors: Janet
authors: J
authors: Chow
authors: Grant J
authors: GJ
authors: Jensen
authors: William M
authors: WM
authors: Clemons
mesh_terms: D002169:Campylobacter Infections / Q000382:microbiology*; D016123:Campylobacter jejuni / Q000502:physiology / Q000648:ultrastructure*; D016764:Cell Polarity; D020285:Cryoelectron Microscopy; D006801:Humans; D015388:Organelles / Q000648:ultrastructure
keywords: Acidocalcisomes; Campylobacterales; chemoreceptors; cryo-EM; cryoelectron tomography; food poisoning; polyphosphate storage granules