title: Dopaminergic neuron destruction reduces hippocampal serotonin 1A receptor uptake of trans-[(18)F]Mefway.
abstract: The purpose of the present study is to investigate the relationship between dopaminergic neuron destruction and 5-HT system changes in a hemiparkinsonian rat model. We performed PET imaging studies with trans-[(18)F]Mefway in a hemiparkinsonian model of unilateral 6-hydroxydopamine (6-OHDA) rats. Region-of-interests (ROIs) were drawn in the hippocampus (HP) and cerebellum (CB). HP uptake, the ratios of specific binding to non-specific binding in the HP, and non-displaceable binding potential (BPND) in the HP were compared between 6-OHDA and control rats. As a result, unilateral 6-OHDA-lesioned rats exhibited significant bilateral reduction of HP uptake and trans-[(18)F]Mefway BPND compared to the intact control group. Therefore, the results demonstrate that destruction of the dopaminergic system causes the reduction of the serotonergic system.
authors: Department of Nuclear Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, 712, Eonjuro, Gangnam-Gu, Seoul 135-720, Republic of Korea.
authors: Minkyung
authors: M
authors: Lee
authors: Department of Nuclear Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, 712, Eonjuro, Gangnam-Gu, Seoul 135-720, Republic of Korea.
authors: Young Hoon
authors: YH
authors: Ryu
authors: Department of Anatomy, Yonsei University Wonju College of Medicine, Wonju 220-701, Republic of Korea.
authors: Won Gil
authors: WG
authors: Cho
authors: Department of Nuclear Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, 712, Eonjuro, Gangnam-Gu, Seoul 135-720, Republic of Korea.
authors: Tae Joo
authors: TJ
authors: Jeon
authors: Department of Neurology, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul 135-720, Republic of Korea.
authors: Chul Hyoung
authors: CH
authors: Lyoo
authors: Department of Neurology, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul 135-720, Republic of Korea.
authors: Yeo Wool
authors: YW
authors: Kang
authors: Department of Neurology, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul 135-720, Republic of Korea.
authors: Soo Jin
authors: SJ
authors: Lee
authors: Department of Pharmacology, Brain Research Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea.
authors: Chul Hoon
authors: CH
authors: Kim
authors: Department of Pharmacology, Brain Research Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea.
authors: Dong Goo
authors: DG
authors: Kim
authors: Department of Chemistry and Biochemistry, Swarthmore College, 500 College Avenue Swarthmore, PA 19081, USA.
authors: Jee Hae
authors: JH
authors: Kang
authors: Department of Nuclear Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, 712, Eonjuro, Gangnam-Gu, Seoul 135-720, Republic of Korea.
authors: Young Beom
authors: YB
authors: Seo
authors: Department of Molecular Imaging, Korea Institute of Radiological & Medical Sciences, Seoul 139-706, Republic of Korea.
authors: Chi Hoon
authors: CH
authors: Yi
authors: Department of Molecular Imaging, Korea Institute of Radiological & Medical Sciences, Seoul 139-706, Republic of Korea.
authors: Kyochul
authors: K
authors: Lee
authors: Department of Molecular Imaging, Korea Institute of Radiological & Medical Sciences, Seoul 139-706, Republic of Korea.
authors: Tae Hyun
authors: TH
authors: Choi
authors: Department of Nuclear Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, 712, Eonjuro, Gangnam-Gu, Seoul 135-720, Republic of Korea. Electronic address: smhany@yuhs.ac.
authors: Jae Yong
authors: JY
authors: Choi
mesh_terms: D000818:Animals; D059290:Dopaminergic Neurons / Q000000981:diagnostic imaging / Q000378:metabolism*; D005462:Fluorine Radioisotopes / Q000493:pharmacokinetics; D006624:Hippocampus / Q000000981:diagnostic imaging / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D020734:Parkinsonian Disorders / Q000000981:diagnostic imaging / Q000378:metabolism*; D010879:Piperazines / Q000493:pharmacokinetics*; D011725:Pyridines / Q000493:pharmacokinetics*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D044282:Receptor, Serotonin, 5-HT1A / Q000378:metabolism*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014018:Tissue Distribution
chemical_list: D005462:Fluorine Radioisotopes; D010879:Piperazines; D011725:Pyridines; D019275:Radiopharmaceuticals; C515664:mefway; D044282:Receptor, Serotonin, 5-HT1A
keywords: 5-HT(1A) receptors; 6-hydroxydopamine; Hemiparkinsonian model; MicroPET; trans-[(18)F]Mefway