title: Magnetomotive optical coherence elastography using magnetic particles to induce mechanical waves.
abstract: Magnetic particles are versatile imaging agents that have found wide spread applicability in diagnostic, therapeutic, and rheology applications. In this study, we demonstrate that mechanical waves generated by a localized inclusion of magnetic nanoparticles can be used for assessment of the tissue viscoelastic properties using magnetomotive optical coherence elastography. We show these capabilities in tissue mimicking elastic and viscoelastic phantoms and in biological tissues by measuring the shear wave speed under magnetomotive excitation. Furthermore, we demonstrate the extraction of the complex shear modulus by measuring the shear wave speed at different frequencies and fitting to a Kelvin-Voigt model.
authors: Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 405 North Mathews Avenue, Urbana, IL, 61801 USA ; Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, 1406 West Green St, Urbana, Illinois 61801, USA.
authors: Adeel
authors: A
authors: Ahmad
authors: Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 405 North Mathews Avenue, Urbana, IL, 61801 USA ; Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, 1406 West Green St, Urbana, Illinois 61801, USA.
authors: Jongsik
authors: J
authors: Kim
authors: Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 405 North Mathews Avenue, Urbana, IL, 61801 USA ; Department of Civil and Environmental Engineering, University of Illinois at Urbana-Champaign, 205 North Mathews Ave, Urbana, Illinois 61801, USA ; Department of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, 1206 West Green St, Urbana, Illinois 61801, USA.
authors: Nahil A
authors: NA
authors: Sobh
authors: Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 405 North Mathews Avenue, Urbana, IL, 61801 USA ; Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, 1406 West Green St, Urbana, Illinois 61801, USA.
authors: Nathan D
authors: ND
authors: Shemonski
authors: Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 405 North Mathews Avenue, Urbana, IL, 61801 USA ; Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, 1406 West Green St, Urbana, Illinois 61801, USA ; Department of Bioengineering, University of Illinois at Urbana-Champaign, 1304 West Springfield Avenue, Urbana, Illinois 61801, USA ; Department of Internal Medicine, University of Illinois at Urbana-Champaign, 506 South Mathews Ave, Urbana, Illinois 61801, USA.
authors: Stephen A
authors: SA
authors: Boppart
keywords: (110.4500) Optical coherence tomography; (170.6935) Tissue characterization; (260.2110) Electromagnetic optics; (350.0350) Other areas of optics; (350.5030) Phase