title: [Changes in lipid and carbohydrate metabolism in patients with severe sepsis of different etiology].
abstract: Different origin (heterogeneity) of sepsis is a key stone in many discussions regarding options for the course and outcome, despite the general rules of development of the pathogenic mechanisms.
  
  
  OBJECTIVE
  To compare data of systemic inflammation (CRP, PCT, IL-8, IL-6, IL-4, TNF-alpha) and markers of endothelial dysfunction (NO, lactate, D-dimers), also lipid (cholesterol, triglycerides, HDL, LDL, VLDL) and carbohydrate metabolism between the two groups of patients with severe intra-abdominal infection (n = 109) and severe sepsis of other etiologies (n = 53).
  
  
  RESULTS
  We found out a significant difference between the groups in serum levels of the CRP, IL-4 and cholesterol at all stages of the study. During severe abdominal sepsis was accompanied by a significantly higher level of cholesterol, LDL and VLDL, as well as higher values of glycaemia. Patients with sepsis other etiology showed a lighter and more dynamic course of the disease was significantly lower 28-day mortality.
authors: O G
authors: OG
authors: Malkova
authors: I N
authors: IN
authors: Leiderman
authors: A L
authors: AL
authors: Levit
authors: A M
authors: AM
authors: Alasheev
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D050260:Carbohydrate Metabolism; D004727:Endothelium / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D050356:Lipid Metabolism; D008875:Middle Aged; D018805:Sepsis / Q000209:etiology* / Q000401:mortality / Q000503:physiopathology; D055815:Young Adult
chemical_list: D015415:Biomarkers