title: Understanding the costs of cancer care before and after diagnosis for the 21 most common cancers in Ontario: a population-based descriptive study.
abstract: BACKGROUND
  The first year after cancer diagnosis is a period of intensive treatment and high cost. We sought to estimate costs for the 21 most common cancers in Ontario in the 3-month period before and the first year after diagnosis.
  
  
  METHODS
  We used the Ontario Cancer Registry to select patients who received diagnoses between 1997 and 2007 at 19 years of age or older, with valid International Classification of Diseases for Oncology (ICD-O) and histology codes, who survived 30 days or longer after diagnosis and had no second cancer within 90 days of the initial cancer (n = 402 399). We used linked administrative data to calculate mean costs for each cancer during the pre- and postdiagnosis periods for patients who died within 1 year after diagnosis and patients who survived beyond 1 year after diagnosis.
  
  
  RESULTS
  Mean prediagnosis costs were $2060 (95% confidence interval [CI] $2023-$2098) for all patients with cancer. Costs ranged from $890 (95% CI $795-$985) for melanoma to $4128 (95% CI $3591-$4664) for liver cancer among patients who survived beyond 1 year after diagnosis, and ranged from $2188 (95% CI $2040-$2336) for esophageal cancer to $5142 (95% CI $4664-$5620) for multiple myeloma among patients who died within 1 year. The mean postdiagnosis cost for our cohort was $25 914 (95% CI $25 782-$26 046). Mean costs were lowest for melanoma ($8611 [95% CI $8221-$9001]) and highest for esophageal cancer ($50 620 [95% CI $47 677-$53 562] among patients who survived beyond 1 year after diagnosis, and ranged from $27 560 (95% CI $25 747-$29 373) for liver cancer to $81 655 (95% CI $58 361-$104 949) for testicular cancer among patients who died within 1 year.
  
  
  CONCLUSIONS
  Our research provides cancer-related cost estimates for the pre- and postdiagnosis phases and offers insight into the economic burden incurred by the Ontario health care system. These estimates can help inform policy-makers' decisions regarding resource allocation for cancer prevention and control, and can serve as important input for economic evaluations.
authors: The Toronto Health Economics and Technology Assessment Collaborative, University Health Network, Toronto, Ont.
authors: Claire
authors: C
authors: de Oliveira
authors: The Toronto Health Economics and Technology Assessment Collaborative, University Health Network, Toronto, Ont.
authors: Karen E
authors: KE
authors: Bremner
authors: BC Cancer Research Centre, Vancouver, BC.
authors: Reka
authors: R
authors: Pataky
authors: Institute for Clinical Evaluative Sciences, Sunnybrook Health Sciences Centre.
authors: Nadia
authors: N
authors: Gunraj
authors: Department of Medicine, University of Toronto, Sunnybrook Health Sciences Centre and Princess Margaret Hospital, Toronto, Ont.
authors: Kelvin
authors: K
authors: Chan
authors: BC Cancer Research Centre, Vancouver, BC ; School of Population and Public Health, University of British Columbia, and the Canadian Centre for Applied Research in Cancer Control, Vancouver BC.
authors: Stuart
authors: S
authors: Peacock
authors: Department of Medicine and Faculty of Pharmacy (Krahn), University of Toronto, University Health Network, and Toronto Health Economics and Technology Assessment Collaborative, Toronto, Ont.
authors: Murray D
authors: MD
authors: Krahn