title: Immunohistochemical analysis of a ruptured basilar top aneurysm autopsied 22 years after embolization with Guglielmi detachable coils.
abstract: The authors report on the histologic and immunohistochemical analyses of a cerebral aneurysm embolized with platinum coils and with the longest observation period. A 58-year-old woman presenting with subarachnoid hemorrhage due to ruptured basilar top aneurysm was treated with Guglielmi detachable coils (GDC) 22 years ago. She was the 15th case since the GDC was introduced. After she died of unrelated causes, an autopsy and thorough histologic examination were performed. Gross examination revealed no adhesion between the aneurysm wall and the surrounding brain tissue. Histologic and immunohistochemical analyses demonstrated that the cavity of the aneurysm was filled with homogeneous collagenous fibrous tissue, while the neck was completely covered by a dense collagenous neointima and a smooth muscle cell layer. The unique histologic results of this case may contribute to a better understanding of the long-term evolution of the healing process in intracranial aneurysms successfully treated with the GDC.
authors: Department of Neurosurgery, Jikei University School of Medicine, Tokyo, Japan Department of Radiology, UCLA Medical Center, Los Angeles, USA.
authors: Ichiro
authors: I
authors: Yuki
authors: Department of Neurosurgery, Hudson Valley Neurosurgery, Los Angeles, California, USA.
authors: Daniel
authors: D
authors: Spitzer
authors: Department of Radiological Sciences, UCLA Medical Center, Los Angeles, California, USA.
authors: Guido
authors: G
authors: Guglielmi
authors: Department of Radiological Sciences, UCLA Medical Center, Los Angeles, California, USA.
authors: Gary
authors: G
authors: Duckwiler
authors: Department of Radiological Sciences, UCLA Medical Center, Los Angeles, California, USA.
authors: Motoaki
authors: M
authors: Fujimoto
authors: Department of Radiological Sciences, UCLA Medical Center, Los Angeles, California, USA.
authors: Hiroyuki
authors: H
authors: Takao
authors: Department of Radiological Sciences, UCLA Medical Center, Los Angeles, California, USA.
authors: Reza
authors: R
authors: Jahan
authors: Department of Radiological Sciences, UCLA Medical Center, Los Angeles, California, USA.
authors: Satoshi
authors: S
authors: Tateshima
authors: Department of Neurosurgery, The Jikei University Hospital, Tokyo, Japan.
authors: Yuichi
authors: Y
authors: Murayama
authors: Department of Radiological Sciences, UCLA Medical Center, Los Angeles, California, USA.
authors: Fernando
authors: F
authors: Vinuela
mesh_terms: D000369:Aged, 80 and over; D017542:Aneurysm, Ruptured / Q000000981:diagnostic imaging / Q000628:therapy*; D004621:Embolization, Therapeutic / Q000295:instrumentation* / Q000639:trends; D004867:Equipment Design / Q000639:trends; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000628:therapy*; D008875:Middle Aged; D011859:Radiography; D013997:Time Factors
keywords: Aneurysm; Coil; Device; History; Intervention