title: Acute total sleep deprivation potentiates cocaine-induced hyperlocomotion in mice.
abstract: Sleep deprivation is common place in modern society. Nowadays, people tend to self-impose less sleep in order to achieve professional or social goals. In the social context, late-night parties are frequently associated with higher availability of recreational drugs with abuse potential. Physiologically, all of these drugs induce an increase in dopamine release in the mesolimbic dopaminergic system, which leads to hyperlocomotion in rodents. Sleep deprivation also seems to play an important role in the events related to the neurotransmission of the dopaminergic system by potentiating its behavioral effects. In this scenario, the aim of the present study was to investigate the effects of total sleep deprivation (6h) on the acute cocaine-induced locomotor stimulation in male mice. Animals were sleep deprived or maintained in their home cages and subsequently treated with an acute i.p. injection of 15mg/kg cocaine or saline and observed in the open field. Total sleep deprivation for 6h potentiated the hyperlocomotion induced by acute cocaine administration. In addition, the cocaine sleep deprived group showed a decreased ratio central/total locomotion compared to the cocaine control group, which might be related to an increase in the impulsiveness of mice. Our data indicate that acute periods of sleep loss should be considered risk factors for cocaine abuse.
authors: Departamento de Psicobiologia, Universidade Federal de São Paulo (UNIFESP), Rua Napoleão de Barros, 925, 04021-002 São Paulo, SP, Brazil. Electronic address: berro.lf@gmail.com.
authors: L F
authors: LF
authors: Berro
authors: Departamento de Farmacologia, Universidade Federal de São Paulo, R. Botucatu, 862, Ed. Leal Prado, 1° andar, 04023-062 São Paulo, SP, Brazil.
authors: R
authors: R
authors: Santos
authors: Departamento de Farmacologia, Universidade Federal de São Paulo, R. Botucatu, 862, Ed. Leal Prado, 1° andar, 04023-062 São Paulo, SP, Brazil.
authors: A W
authors: AW
authors: Hollais
authors: Departamento de Farmacologia, Universidade Federal de São Paulo, R. Botucatu, 862, Ed. Leal Prado, 1° andar, 04023-062 São Paulo, SP, Brazil.
authors: R
authors: R
authors: Wuo-Silva
authors: Departamento de Farmacologia, Universidade Federal de São Paulo, R. Botucatu, 862, Ed. Leal Prado, 1° andar, 04023-062 São Paulo, SP, Brazil.
authors: D F
authors: DF
authors: Fukushiro
authors: Departamento de Farmacologia, Universidade Federal de São Paulo, R. Botucatu, 862, Ed. Leal Prado, 1° andar, 04023-062 São Paulo, SP, Brazil.
authors: E
authors: E
authors: Mári-Kawamoto
authors: Departamento de Farmacologia, Universidade Federal de São Paulo, R. Botucatu, 862, Ed. Leal Prado, 1° andar, 04023-062 São Paulo, SP, Brazil.
authors: J M
authors: JM
authors: Costa
authors: Departamento de Farmacologia, Universidade Federal de São Paulo, R. Botucatu, 862, Ed. Leal Prado, 1° andar, 04023-062 São Paulo, SP, Brazil.
authors: T F
authors: TF
authors: Trombin
authors: Departamento de Farmacologia, Universidade Federal de São Paulo, R. Botucatu, 862, Ed. Leal Prado, 1° andar, 04023-062 São Paulo, SP, Brazil.
authors: C L
authors: CL
authors: Patti
authors: Departamento de Farmacologia, Universidade Federal de São Paulo, R. Botucatu, 862, Ed. Leal Prado, 1° andar, 04023-062 São Paulo, SP, Brazil.
authors: S B
authors: SB
authors: Grapiglia
authors: Departamento de Psicobiologia, Universidade Federal de São Paulo (UNIFESP), Rua Napoleão de Barros, 925, 04021-002 São Paulo, SP, Brazil.
authors: S
authors: S
authors: Tufik
authors: Departamento de Psicobiologia, Universidade Federal de São Paulo (UNIFESP), Rua Napoleão de Barros, 925, 04021-002 São Paulo, SP, Brazil. Electronic address: ml.andersen12@gmail.com.
authors: M L
authors: ML
authors: Andersen
authors: Departamento de Psicobiologia, Universidade Federal de São Paulo (UNIFESP), Rua Napoleão de Barros, 925, 04021-002 São Paulo, SP, Brazil; Departamento de Farmacologia, Universidade Federal de São Paulo, R. Botucatu, 862, Ed. Leal Prado, 1° andar, 04023-062 São Paulo, SP, Brazil.
authors: R
authors: R
authors: Frussa-Filho
mesh_terms: D000818:Animals; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003042:Cocaine / Q000494:pharmacology*; D006948:Hyperkinesis / Q000139:chemically induced* / Q000523:psychology; D008297:Male; D051379:Mice; D012892:Sleep Deprivation / Q000523:psychology*
chemical_list: D000697:Central Nervous System Stimulants; D003042:Cocaine
keywords: Cocaine; Hyperlocomotion; Impulsivity; Open field; Sleep deprivation