title: Results of a prospective thyroid ultrasound screening program in adenomatous polyposis patients.
abstract: BACKGROUND
  Patients with adenomatous polyposis may be at increased risk for developing thyroid cancer (TC). However, screening guidelines for TC in these patients are not well established.
  
  
  METHODS
  Patients with a diagnosis of familial adenomatous polyposis, attenuated familial adenomatous polyposis, and gene mutation-negative adenomatous polyposis enrolled in our Hereditary Colorectal Cancer Family Registry were eligible for a screening thyroid ultrasound (US). Findings were reviewed by the study endocrinologist and intervention and/or follow-up determined.
  
  
  RESULTS
  Fifty patients underwent screening thyroid US. Thirty-four (68%) patients had abnormal findings on US, including 27 (79%) with thyroid nodules. In 7 patients, US-detected thyroid nodules met established criteria for fine-needle aspiration. Of the 6 patients who underwent fine-needle aspiration, 2 (4%) were diagnosed with papillary TC. Both of these patients were female.
  
  
  CONCLUSIONS
  A large proportion of adenomatous polyposis patients will have abnormal results on thyroid US, including suspicious-appearing thyroid nodules that when biopsied are malignant. Female patients have an apparently greater risk of developing TC. Polyposis patients, especially women, should be offered participation in a thyroid US screening program.
authors: Department of Surgery, Colorectal Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
authors: Emily
authors: E
authors: Steinhagen
authors: Department of Surgery, Colorectal Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
authors: Vanessa W
authors: VW
authors: Hui
authors: Department of Surgery, Colorectal Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
authors: Rachel A
authors: RA
authors: Levy
authors: Department of Medicine, Gastroenterology and Nutrition Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
authors: Arnold J
authors: AJ
authors: Markowitz
authors: Department of Medicine, Endocrinology Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
authors: Stephanie
authors: S
authors: Fish
authors: Department of Surgery, Head and Neck Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
authors: Richard J
authors: RJ
authors: Wong
authors: Department of Surgery, Colorectal Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
authors: Rupa
authors: R
authors: Sood
authors: Department of Surgery, Colorectal Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
authors: Stephanie M
authors: SM
authors: Ochman
authors: Department of Surgery, Colorectal Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Electronic address: guillemj@mskcc.org.
authors: José G
authors: JG
authors: Guillem
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000150:complications*; D000293:Adolescent; D000328:Adult; D044963:Biopsy, Fine-Needle; D002277:Carcinoma / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D002291:Carcinoma, Papillary; D002648:Child; D055088:Early Detection of Cancer / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012042:Registries; D012307:Risk Factors; D000077273:Thyroid Cancer, Papillary; D013961:Thyroid Gland / Q000473:pathology; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology; D016606:Thyroid Nodule / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D014463:Ultrasonography; D055815:Young Adult
keywords: Adenomatous polyposis; Screening for cancer prevention; Thyroid cancer