title: Characterization of hydromechanical stress in aerated stirred tanks up to 40 m(3) scale by measurement of maximum stable drop size.
abstract: BACKGROUND
  Turbulence intensity, or hydromechanical stress, is a parameter that influences a broad range of processes in the fields of chemical engineering and biotechnology. Fermentation processes are often characterized by high agitation and aeration intensity resulting in high gas void fractions of up to 20% in large scale reactors. Very little experimental data on hydromechanical stress for such operating conditions exists because of the problems associated with measuring hydromechanical stress under aeration and intense agitation.
  
  
  RESULTS
  An indirect method to quantify hydromechanical stress for aerated operating conditions by the measurement of maximum stable drop size in a break-up controlled dispersion was applied to characterize hydromechanical stress in reactor scales of 50 L, 3 m(3) and 40 m(3) volume with a broad range of operating conditions and impeller geometries (Rushton turbines). Results for impellers within each scale for the ratio of maximum to specific energy dissipation rate ϕ based on measured values of maximum stable drop size for aerated operating conditions are qualitatively in agreement with results from literature correlations for unaerated operating conditions. Comparison of data in the different scales shows that there is a scale effect that results in higher values for ϕ in larger reactors. This behavior is not covered by the classic theory of turbulent drop dispersion but is in good agreement with the theory of turbulence intermittency. The data for all impeller configurations and all aeration rates for the three scales can be correlated within ±20% when calculated values for ϕ based on the measured values for dmax are used to calculate the maximum local energy dissipation rate. A correlation of the data for all scales and all impeller configurations in the form ϕ = 2.3∙(ϕunaerated)(0.34)∙(DR)(0.543) is suggested that successfully models the influence of scale and impeller geometry on ϕ for aerated operating conditions.
  
  
  CONCLUSIONS
  The results show that besides the impeller geometry, also aeration and scale strongly influence hydromechanical stress. Incorporating these effects is beneficial for a successful scale up or scale down of this parameter. This can be done by applying the suggested correlation or by measuring hydromechanical stress with the experimental method used in this study.
authors: AVT.Biochemical Engineering, RWTH Aachen University, Worringerweg 1, Aachen 52074, Germany.
authors: Andreas
authors: A
authors: Daub
authors: AVT.Biochemical Engineering, RWTH Aachen University, Worringerweg 1, Aachen 52074, Germany.
authors: Marina
authors: M
authors: Böhm
authors: AVT.Biochemical Engineering, RWTH Aachen University, Worringerweg 1, Aachen 52074, Germany.
authors: Stefanie
authors: S
authors: Delueg
authors: AVT.Biochemical Engineering, RWTH Aachen University, Worringerweg 1, Aachen 52074, Germany.
authors: Markus
authors: M
authors: Mühlmann
authors: Sandoz GmbH, Anti-Infectives Operations Development, Biochemiestraße 10, Kundl A-6250, Austria.
authors: Gerhard
authors: G
authors: Schneider
authors: AVT.Biochemical Engineering, RWTH Aachen University, Worringerweg 1, Aachen 52074, Germany.
authors: Jochen
authors: J
authors: Büchs
keywords: Aeration; Drop size; Energy dissipation; Hydromechanical stress; Multiphase reactors; Turbulence