title: Near-infrared spectroscopic study of frontopolar activation during face-to-face conversation in major depressive disorder and bipolar disorder.
abstract: Major depressive disorder (MDD) and bipolar disorder (BD) patients show speech characteristics that vary greatly according to mood state. In a previous study, we found impaired temporal and right inferior frontal gyrus (IFG) activation in schizophrenia during face-to-face conversation; no study had, however, previously investigated mood disorders during face-to-face conversation. Here, we investigated frontal and temporal lobe activation during conversation in patients with MDD and BD. Frontal and temporal lobe activation was measured using near-infrared spectroscopy (NIRS) in 29 patients with MDD, 31 patients with BD, and 31 normal controls (NC). We compared continuous activation and rapid change of activation with talk/listen phase changes during the conversation and analyzed the correlation between these indices and clinical variables. Both the MDD and BD groups showed decreased continuous activation in the left dorsolateral prefrontal (DLPFC) and left frontopolar cortices (FPCs); they also showed decreased rapid change in bilateral FPC activation. In the MDD group, the rapid change of activation was positively correlated with Global Assessment of Functioning (GAF) scores. In the BD group, continuous activation was negatively correlated with age of onset. These results indicate that frontal activation during conversation decreases in both MDD and BD. However, both continuous activation and rapid change may reflect the pathophysiological character of MDD and BD; in particular, the reduced amount of rapid change in the right FPC may be related to impaired adaptive ability in MDD.
authors: Department of Psychiatry and Neuroscience, Gunma University of Graduate School of Medicine, 3-39-22 Showa, Maebashi, Gunma 371-8511, Japan. Electronic address: tyuichi@gunma-u.ac.jp.
authors: Yuichi
authors: Y
authors: Takei
authors: Department of Psychiatry and Neuroscience, Gunma University of Graduate School of Medicine, 3-39-22 Showa, Maebashi, Gunma 371-8511, Japan.
authors: Masashi
authors: M
authors: Suda
authors: Department of Psychiatry and Neuroscience, Gunma University of Graduate School of Medicine, 3-39-22 Showa, Maebashi, Gunma 371-8511, Japan.
authors: Yoshiyuki
authors: Y
authors: Aoyama
authors: Department of Psychiatry and Neuroscience, Gunma University of Graduate School of Medicine, 3-39-22 Showa, Maebashi, Gunma 371-8511, Japan.
authors: Noriko
authors: N
authors: Sakurai
authors: Department of Psychiatry and Neuroscience, Gunma University of Graduate School of Medicine, 3-39-22 Showa, Maebashi, Gunma 371-8511, Japan.
authors: Minami
authors: M
authors: Tagawa
authors: Department of Psychiatry and Neuroscience, Gunma University of Graduate School of Medicine, 3-39-22 Showa, Maebashi, Gunma 371-8511, Japan.
authors: Tomokazu
authors: T
authors: Motegi
authors: Department of Psychiatry and Neuroscience, Gunma University of Graduate School of Medicine, 3-39-22 Showa, Maebashi, Gunma 371-8511, Japan.
authors: Miho
authors: M
authors: Yamaguchi
authors: Department of Psychiatry and Neuroscience, Gunma University of Graduate School of Medicine, 3-39-22 Showa, Maebashi, Gunma 371-8511, Japan.
authors: Kosuke
authors: K
authors: Narita
authors: Department of Psychiatry and Neuroscience, Gunma University of Graduate School of Medicine, 3-39-22 Showa, Maebashi, Gunma 371-8511, Japan.
authors: Masato
authors: M
authors: Fukuda
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000378:metabolism* / Q000523:psychology; D001931:Brain Mapping / Q000379:methods; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000378:metabolism* / Q000523:psychology; D005260:Female; D005625:Frontal Lobe / Q000098:blood supply / Q000378:metabolism*; D006801:Humans; D007398:Interpersonal Relations; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010108:Oxyhemoglobins / Q000378:metabolism; D011569:Psychiatric Status Rating Scales; D019265:Spectroscopy, Near-Infrared; D013060:Speech; D013702:Temporal Lobe / Q000098:blood supply / Q000378:metabolism*; D055815:Young Adult
chemical_list: D010108:Oxyhemoglobins
keywords: Bipolar disorder; Major depression; Mood disorder; Near-infrared spectroscopy; Social cognition; Talk