title: Myeloid-derived suppressor cells link inflammation to cancer.
abstract: Our recent work has provided the first evidence that MDSCs promote chronic colonic inflammation and colitis-associated carcinogenesis. Our findings not only reveal a novel function of MDSCs in connecting inflammation to cancer, but also provide a rationale for developing effective therapeutic strategies to subvert inflammation- and tumor-induced immunosuppression.
authors: Laboratory for Inflammation and Cancer; the Biodesign Institute at Arizona State University; Tempe, AZ USA.
authors: Dingzhi
authors: D
authors: Wang
authors: Laboratory for Inflammation and Cancer; the Biodesign Institute at Arizona State University; Tempe, AZ USA ; Department of Chemistry and Biochemistry; Arizona State University; Tempe, AZ USA ; Department of Research and Division of Gastroenterology; Mayo Clinic; Scottsdale, AZ USA.
authors: Raymond N
authors: RN
authors: DuBois
keywords: CXCR2; colitis-associated tumorigenesis; colorectal cancer; inflammation; myeloid-derived suppressor cells