title: Liposarcoma miRNA signatures identified from genome-wide miRNA expression profiling.
abstract: OBJECTIVE
  To identify the miRNA expression profile of liposarcoma (LPS) that could facilitate detection of LPS, and provide the basis for further investigation of molecular-targeted therapeutic drugs.
  
  
  METHODS
  A real-time quantitative PCR assay was performed to analyze the expression of 1888 miRNAs from 25 LPS tumor tissue samples, 16 samples of adipose tissue adjacent to the tumors and 18 normal adipose tissue samples from patients with LPS.
  
  
  RESULTS
  Ten dysregulated miRNAs were identified that effectively distinguished LPS tissue from adipose tissue and benign lipoma tissue, and LPS tumor tissues from normal adipose tissues in LPS patients. Furthermore, the expression profiles of miRNAs could also classify the subtype of LPS.
  
  
  CONCLUSIONS
  The identified miRNAs appear to be novel biomarkers for the detection of LPS, and may contribute to an understanding of the mechanisms of LPS tumorigenesis and its development, and further elucidate the characteristics of LPS subtypes.
authors: Department of Oncology, Zhongshan Hospital, Fudan University, Shanghai, China.
authors: Yuhong
authors: Y
authors: Zhou
authors: Yong
authors: Y
authors: Zhang
authors: Yuan
authors: Y
authors: Huang
authors: Ruoying
authors: R
authors: Tan
authors: Tianshu
authors: T
authors: Liu
authors: Rongyuan
authors: R
authors: Zhuang
authors: Miaojun
authors: M
authors: Zhu
authors: Wumei
authors: W
authors: Han
authors: Yingyong
authors: Y
authors: Hou
authors: Ju
authors: J
authors: Liu
authors: Li
authors: L
authors: Zhang
authors: Yaping
authors: Y
authors: Jiang
authors: Hanxing
authors: H
authors: Tong
authors: Yebo
authors: Y
authors: Shao
authors: Jun
authors: J
authors: Zhu
authors: Weiqi
authors: W
authors: Lu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D055106:Genome-Wide Association Study; D006801:Humans; D008080:Liposarcoma / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D059467:Transcriptome
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs
keywords: RT-quantitative PCR; dysregulation; liposarcoma; miRNAs