title: Taming HIV-related inflammation with physical activity: a matter of timing.
abstract: Many sets of data indicate that HIV-infected individuals maintain a low level of chronic immune activation and inflammation even in the presence of effective antiretroviral therapy (ART). This residual immune activation seems to be associated with accelerated aging and an increased incidence of non-AIDS-defining illnesses. Several published studies suggest that physical activity is a beneficial nonpharmacological intervention to reduce chronic inflammation. However, currently available data on the potential benefits of regular physical exercises for HIV-infected individuals are limited. Nonetheless, increasing evidence suggests that the introduction of regular physical exercise in the clinical management of HIV-infected individuals may have a significant positive impact in reducing some of the long-term complications of both infection and ART. Based on a comprehensive review of the existing data, we propose that regular physical exercise should be further studied as a potential antiinflammatory, nonpharmacological approach to be used to treat HIV residual disease and non-AIDS-defining illnesses in ART-treated HIV-infected individuals.
authors: 1 Department of Public Health and Infectious Diseases, Istituto Pasteur-Fondazione Cenci Bolognetti, University of Rome "Sapienza," Rome, Italy .
authors: Gabriella
authors: G
authors: d'Ettorre
authors: Giancarlo
authors: G
authors: Ceccarelli
authors: Noemi
authors: N
authors: Giustini
authors: Claudio M
authors: CM
authors: Mastroianni
authors: Guido
authors: G
authors: Silvestri
authors: Vincenzo
authors: V
authors: Vullo
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use; D015444:Exercise; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000517:prevention & control*
chemical_list: D019380:Anti-HIV Agents