title: Inhibitory effects of Rubi Fructus extracts on hepatic steatosis development in high-fat diet-induced obese mice.
abstract: The present study was performed to investigate the potential effects of the unripened dried fruit of Rubus coreanus Miq., Rubi Fructus (RF), on hepatic steatosis and lipid metabolism in mice fed with a high-fat diet (HFD) known to induce obesity and hyperlipidaemia. Rubi Fructus extract (RFex) fed mice demonstrated a reduced body weight and adipose tissue weight. RFex fed mice also demonstrated decreased aminotransferase levels, lipid contents [triglyceride (TG), total cholesterol (TC) and low-density lipoprotein-cholesterol (LDL-C)], leptin content and increased high‑density lipoprotein-cholesterol (HDL‑C) contents in the plasma. These effects were accompanied by a decreased expression of lipogenic genes, including sterol regulatory element binding protein-1c, liver X receptor, fatty acid synthase (FAS), acetyl‑CoA carboxylase, cluster of differentiation 36, lipoprotein lipase and decreased lipogenic enzyme FAS and 3-hydroxy-3 methylglutamyl coenzyme reductase enzyme activities, while elevating carnitine palmitoyltrasferase-1 activity. Based on these results, the present study hypothesized that the inhibitory effect on hepatic steatosis of RFex is the result of the suppression of lipid synthesis in mice fed with HFD, suggesting that RFex may be beneficial in preventing hepatic steatosis and liver lipotoxicity.
authors: Industrial Bioresource Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-606, Republic of Korea.
authors: Mi Kyung
authors: MK
authors: Nam
authors: Industrial Bioresource Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-606, Republic of Korea.
authors: Hye Ran
authors: HR
authors: Choi
authors: Lee's Biotech Co., Daejeon 305-806, Republic of Korea.
authors: Jin Sook
authors: JS
authors: Cho
authors: Industrial Bioresource Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-606, Republic of Korea.
authors: Soo Min
authors: SM
authors: Cho
authors: Healthcare Claims and Management Incorp., Jeonju, Chonbuk 949-14, Republic of Korea.
authors: Ki Chan
authors: KC
authors: Ha
authors: Department of Gastroenterology, Wonkwang University School of Medicine, Iksan, Chonbuk 500-711, Republic of Korea.
authors: Tae-Hyeon
authors: TH
authors: Kim
authors: Industrial Bioresource Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-606, Republic of Korea.
authors: Hee-Young
authors: HY
authors: Ryu
authors: Industrial Bioresource Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-606, Republic of Korea.
authors: Young-Ik
authors: YI
authors: Lee
mesh_terms: D000103:Acetyl-CoA Carboxylase / Q000235:genetics / Q000378:metabolism; D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D059305:Diet, High-Fat; D064429:Fatty Acid Synthases / Q000235:genetics / Q000378:metabolism; D005234:Fatty Liver / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D005638:Fruit / Q000737:chemistry / Q000378:metabolism; D015870:Gene Expression / Q000187:drug effects; D020738:Leptin / Q000097:blood; D050356:Lipid Metabolism / Q000187:drug effects* / Q000235:genetics; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D065856:Rubus / Q000737:chemistry* / Q000378:metabolism; D051780:Sterol Regulatory Element Binding Protein 1 / Q000235:genetics / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
chemical_list: D020738:Leptin; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D010936:Plant Extracts; D051780:Sterol Regulatory Element Binding Protein 1; D014280:Triglycerides; D002784:Cholesterol; D064429:Fatty Acid Synthases; D000103:Acetyl-CoA Carboxylase