title: Tumor attributes predicting cutaneous metastatic destiny: a report of two interesting cases.
abstract: Cutaneous metastases are the result of complex interaction between the tumor cells ("seed") and the host environment ("soil"). Metastases to the skin can be an early sign of internal malignancy or represent recurrence of the primary tumor and portends a poorer prognosis. Invasion and metastasis are the hallmarks of on cogenesis. Skin is the largest organ in the body, but the incidence of metastases is low. With advances in molecular biology, factors responsible for the initiation and perpetuation of metastatic tumor cells at distant sites are being elucidated. The concept of "pre-metastatic niche" and interaction between various chemokines has given a new outlook in understanding the organ specificity of metastatic tumor cells. We present two cases of cutaneous metastases with interesting clinical findings correlating with its biologic subtypes.
authors: Department of Dermatology, Apollo Cancer Hospital, Chennai, Tamil Nadu, India.
authors: Ravichandran
authors: R
authors: Gurumurthi
authors: Department of Oncology, Apollo Cancer Hospital, Chennai, Tamil Nadu, India.
authors: Raja
authors: R
authors: Thirumalai
authors: Department of Oncology, Apollo Cancer Hospital, Chennai, Tamil Nadu, India.
authors: Jose M
authors: JM
authors: Easow
authors: Department of Dermatology, Apollo Cancer Hospital, Chennai, Tamil Nadu, India.
authors: Subhashini
authors: S
authors: Mohan
keywords: Breast carcinoma; chemokines; cutaneous metastases; pre-metastatic niche; prostate carcinoma