title: Microarray analysis of differentially expressed gene responses to bisphenol A in Arabidopsis.
abstract: Environmental levels of bisphenol A (BPA) are a global concern because the compound can cause damage to reproductive organs, the thyroid gland, and brain tissues at developmental stages. Plants are important in removing BPA from the atmosphere, soil, and water. However, knowledge on the mechanism by which plants respond to this compound is limited. To determine the response mechanism of plants to BPA, we used a microarray system to analyze the gene expression patterns of Arabidopsis thaliana after irrigation with 3.0 mM BPA. We identified 651 genes that were differentially expressed upregulated and 470 genes that were downregulated by BPA. These genes may specifically contribute to BPA uptake, transformation, conjugation, and compartmentation in plants. The potential function of upregulated genes in plant defense against BPA was also determined.
authors: Shanghai Key Laboratory of Agricultural Genetics and Breeding, Biotechnology Research Institute of Shanghai Academy of Agricultural Sciences.
authors: Yong-Sheng
authors: YS
authors: Tian
authors: Xiao-Fen
authors: XF
authors: Jin
authors: Xiao-Yan
authors: XY
authors: Fu
authors: Wei
authors: W
authors: Zhao
authors: Hong-Juan
authors: HJ
authors: Han
authors: Bo
authors: B
authors: Zhu
authors: Man-
authors: M
authors: Liu
authors: Quan-Hong
authors: QH
authors: Yao
mesh_terms: D000395:Air Pollutants, Occupational / Q000633:toxicity*; D017360:Arabidopsis / Q000187:drug effects* / Q000235:genetics* / Q000378:metabolism; D001559:Benzhydryl Compounds / Q000378:metabolism / Q000633:toxicity*; D015536:Down-Regulation / Q000187:drug effects; D018506:Gene Expression Regulation, Plant / Q000187:drug effects*; D046228:Microarray Analysis; D010636:Phenols / Q000378:metabolism / Q000633:toxicity*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015854:Up-Regulation / Q000187:drug effects; D000098826:Bisphenol A Compounds
chemical_list: D000395:Air Pollutants, Occupational; D001559:Benzhydryl Compounds; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds