title: Toxicokinetics of T-2 toxin and its major metabolites in broiler chickens after intravenous and oral administration.
abstract: T-2 toxin, one of the most toxic trichothecene mycotoxins, causes economic losses in animal production. Little information is available on the toxicokinetic parameters of T-2 toxin and its major metabolites (i.e., HT-2 toxin and T-2 triol) in broiler chickens. In this study, toxicokinetics of T-2 toxin and its major metabolites were evaluated in broiler chickens after a single intravenous (0.5 mg/kg b.w.) and multiple oral administrations (2.0 mg/kg b.w., every 12 h for 2 days). Plasma concentration profiles of T-2 toxin and its metabolites were analyzed by a noncompartmental model method. Following intravenous administration, the terminal elimination half-lives (t(1/2λz)) of T-2 toxin, HT-2 toxin, and T-2 triol were 17.33 ± 1.07 min, 33.62 ± 3.08 min, and 9.60 ± 0.50 min, respectively. Following multiple oral administrations, no plasma levels above the limit of quantification were observed for HT-2 toxin. The t(1/2λz) of T-2 toxin and T-2 triol was 23.40 ± 2.94 min and 87.60 ± 29.40 min, respectively. Peak plasma concentrations (Cmax ) of 53.10 ± 10.42 ng/mL (T-2 toxin) and 47.64 ± 9.19 ng/mL (T-2 triol) were observed at Tmax of 13.20 ± 4.80 min and 38.40 ± 15.00 min, respectively. T-2 toxin had a low absolute oral bioavailability (17.07%). Results showed that the T-2 toxin was rapidly absorbed and most of the T-2 toxin was extensively transformed to metabolites in broiler chickens.
authors: National Reference Laboratory of Veterinary Drug Residues (SCAU), College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
authors: Y X
authors: YX
authors: Sun
authors: X
authors: X
authors: Yao
authors: S N
authors: SN
authors: Shi
authors: G J
authors: GJ
authors: Zhang
authors: L X
authors: LX
authors: Xu
authors: Y J
authors: YJ
authors: Liu
authors: B H
authors: BH
authors: Fang
mesh_terms: D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D002645:Chickens; D006207:Half-Life; D007275:Injections, Intravenous; D015394:Molecular Structure; D011201:Poultry Diseases / Q000139:chemically induced* / Q000378:metabolism; D013605:T-2 Toxin / Q000008:administration & dosage / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics* / Q000633:toxicity
chemical_list: D013605:T-2 Toxin