title: Hypoglycemic effect of Gynostemma pentaphyllum saponins by enhancing the Nrf2 signaling pathway in STZ-inducing diabetic rats.
abstract: Gynostemma pentaphyllum (GP) is a natural plant resources for diabetes therapy, however, there is little research on the mechanisms of GP. The present study was undertaken to characterize if G. pentaphyllum saponins (GPs) is the principal active compound of GP responsible for anti-diabetes, and to examine the relativity between blood glucose modulate and antioxidation. The GPs-treated streptozotocin diabetic rats had a more effective hypoglycemic status than those of diabetic control rats, which also ameliorate dyslipidemia. GPs has increased SOD and GSH-px activities, and the spleen and thymus indexes in diabetic rats. The insulin levels in the GPs-treated groups were significantly higher than diabetic control group. Our finding provides a new insight into the application of GPs for the treatment of oxidative stress related diseases.
authors: Applied Chemical Key Lab of Hebei Province, Department of Biological Engineering, Yanshan University, No. 438 Hebei Street, Qinhuangdao, 066004, China. dwgao@ysu.edu.cn.
authors: Dawei
authors: D
authors: Gao
authors: Department of Pathology, The First Hospital of Qinhuangdao, No. 258 Cultural Road, Qinhuangdao, 066004, China.
authors: Min
authors: M
authors: Zhao
authors: Department of Pathology, The First Hospital of Qinhuangdao, No. 258 Cultural Road, Qinhuangdao, 066004, China.
authors: Ximing
authors: X
authors: Qi
authors: Applied Chemical Key Lab of Hebei Province, Department of Biological Engineering, Yanshan University, No. 438 Hebei Street, Qinhuangdao, 066004, China.
authors: Yanping
authors: Y
authors: Liu
authors: Applied Chemical Key Lab of Hebei Province, Department of Biological Engineering, Yanshan University, No. 438 Hebei Street, Qinhuangdao, 066004, China.
authors: Nan
authors: N
authors: Li
authors: Applied Chemical Key Lab of Hebei Province, Department of Biological Engineering, Yanshan University, No. 438 Hebei Street, Qinhuangdao, 066004, China.
authors: Zhiwei
authors: Z
authors: Liu
authors: Applied Chemical Key Lab of Hebei Province, Department of Biological Engineering, Yanshan University, No. 438 Hebei Street, Qinhuangdao, 066004, China.
authors: Yanhong
authors: Y
authors: Bian
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D005979:Glutathione Peroxidase / Q000378:metabolism; D029774:Gynostemma / Q000737:chemistry*; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051267:NF-E2-Related Factor 2 / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal; D017208:Rats, Wistar; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology*; D015398:Signal Transduction / Q000187:drug effects*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D008055:Lipids; D051267:NF-E2-Related Factor 2; C495637:Nfe2l2 protein, rat; D010936:Plant Extracts; D012503:Saponins; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase
keywords: Gynostemma pentaphyllum saponins; Hypoglycemia; Insulin; Nuclear factor erythroid 2-related factor 2 (Nrf2); Reactive oxygen species