title: Interlaced photoacoustic and ultrasound imaging system with real-time coregistration for ovarian tissue characterization.
abstract: Coregistered ultrasound (US) and photoacoustic imaging are emerging techniques for mapping the echogenic anatomical structure of tissue and its corresponding optical absorption. We report a 128-channel imaging system with real-time coregistration of the two modalities, which provides up to 15 coregistered frames per second limited by the laser pulse repetition rate. In addition, the system integrates a compact transvaginal imaging probe with a custom-designed fiber optic assembly for in vivo detection and characterization of human ovarian tissue. We present the coregistered US and photoacoustic imaging system structure, the optimal design of the PC interfacing software, and the reconfigurable field programmable gate array operation and optimization. Phantom experiments of system lateral resolution and axial sensitivity evaluation, examples of the real-time scanning of a tumor-bearing mouse, and ex vivo human ovaries studies are demonstrated.
authors: King Abdulaziz University, Department of Electrical and Computer Engineering, PO Box 80204, Jeddah 21589, Saudi ArabiabUniversity of Connecticut, Department of Biomedical Engineering, 371 Fairfield Way; U-4157, Storrs, Connecticut 06269-4157, United State.
authors: Umar
authors: U
authors: Alqasemi
authors: University of Connecticut, Departments of Electrical and Computer Engineering, 371 Fairfield Way; U-4157, Storrs, Connecticut 06269-4157, United States.
authors: Hai
authors: H
authors: Li
authors: University of Connecticut, Department of Biomedical Engineering, 371 Fairfield Way; U-4157, Storrs, Connecticut 06269-4157, United States.
authors: Guangqian
authors: G
authors: Yuan
authors: University of Connecticut, Department of Biomedical Engineering, 371 Fairfield Way; U-4157, Storrs, Connecticut 06269-4157, United States.
authors: Patrick
authors: P
authors: Kumavor
authors: University of Connecticut, Department of Biomedical Engineering, 371 Fairfield Way; U-4157, Storrs, Connecticut 06269-4157, United States.
authors: Saeid
authors: S
authors: Zanganeh
authors: University of Connecticut, Department of Biomedical Engineering, 371 Fairfield Way; U-4157, Storrs, Connecticut 06269-4157, United StatescUniversity of Connecticut, Departments of Electrical and Computer Engineering, 371 Fairfield Way; U-4157, Storrs, Con.
authors: Quing
authors: Q
authors: Zhu
mesh_terms: D000818:Animals; D004867:Equipment Design; D005260:Female; D006801:Humans; D051379:Mice; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging; D010053:Ovary / Q000000981:diagnostic imaging*; D061088:Photoacoustic Techniques / Q000295:instrumentation* / Q000379:methods*; D014463:Ultrasonography / Q000295:instrumentation* / Q000379:methods*