title: Small RNAs break out: the molecular cell biology of mobile small RNAs.
abstract: Small RNAs that function in a non-cell autonomous manner are becoming increasingly recognized as regulatory molecules with the potential to transmit information between cells, organisms and species. In plants and nematodes, small RNA mobility can be genetically dissected to provide information about the nature of the mobile RNA species, their distribution in the organism and inside cells, as well as the cellular machinery required for mobility, including channel proteins and cellular trafficking factors. Mobile RNAs function in antiviral defence, cell signalling and gene expression regulation, and might also mediate transgenerational epigenetic inheritance.
authors: Gurdon Institute and Department of Genetics, University of Cambridge, The Henry Wellcome Building of Cancer and Developmental Biology, Tennis Court Road, Cambridge CB2 1QN, UK.
authors: Peter
authors: P
authors: Sarkies
authors: Gurdon Institute and Department of Genetics, University of Cambridge, The Henry Wellcome Building of Cancer and Developmental Biology, Tennis Court Road, Cambridge CB2 1QN, UK.
authors: Eric A
authors: EA
authors: Miska
mesh_terms: D000818:Animals; D001692:Biological Transport; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism; D044127:Epigenesis, Genetic; D006801:Humans; D007109:Immunity / Q000235:genetics; D010944:Plants / Q000235:genetics / Q000378:metabolism; D034741:RNA, Small Interfering; D058727:RNA, Small Untranslated / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics; D014777:Virus Diseases / Q000235:genetics / Q000276:immunology
chemical_list: D034741:RNA, Small Interfering; D058727:RNA, Small Untranslated