title: The Roles of Lysosomes in Inflammation and Autoimmune Diseases.
abstract: Lysosomes perform a range of functions, some of which, such as degradation, are common to all cell types. Others, such as secretion or lysosomal exocytosis, are more specialised and tend to involve fusion of this organelle with the cell surface to release its contents. This review describes lysosomal regulation of the inflammatory glucocorticoid signaling pathways, and summarizes the roles of lysosomes in negatively or positively modulating the production of inflammatory cytokines. We also review the characteristic changes in lysosomal hydrolases and membrane proteins in common autoimmune diseases. Finally, future directions in lysosome research are proposed, with it being suggested that the role of lysosomes will continue to be of growing interest in immunity research.
authors: a National Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences , Beijing , China.
authors: Wei
authors: W
authors: Ge
authors: b Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University , Shenyang , China.
authors: Dongxu
authors: D
authors: Li
authors: a National Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences , Beijing , China.
authors: Yanpan
authors: Y
authors: Gao
authors: a National Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences , Beijing , China.
authors: Xuetao
authors: X
authors: Cao
mesh_terms: D001327:Autoimmune Diseases / Q000276:immunology*; D016207:Cytokines / Q000276:immunology; D005089:Exocytosis / Q000276:immunology; D005938:Glucocorticoids / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D006867:Hydrolases / Q000276:immunology / Q000378:metabolism; D007249:Inflammation / Q000276:immunology*; D018836:Inflammation Mediators / Q000276:immunology*; D008247:Lysosomes / Q000276:immunology*; D010587:Phagocytosis / Q000276:immunology; D011965:Receptors, Glucocorticoid / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology
chemical_list: D016207:Cytokines; D005938:Glucocorticoids; D018836:Inflammation Mediators; D011965:Receptors, Glucocorticoid; D006867:Hydrolases
keywords: autoimmune diseases; cytokines; inflammation; lysosome