title: A schematic workflow for collecting information about the interaction between copy number variants and microRNAs using existing resources.
abstract: MicroRNAs (miRNAs) and copy number variations (CNVs) are two extensively studied genomic components in the field of modern biology-as they have been found to be associated with many disorders such as cancer, Alzheimer, pancreatitis, HIV susceptibility, beta-thalassemia, and glomerulonephritis. Several studies suggested that an alteration in CNV-miRNA interaction could result in some human diseases such as cancer. Therefore, the possible miRNA-binding site information within the CNV genes opens new avenues in understanding such disorders. In this chapter, we present a schematic approach for collecting the information on CNV-miRNA interactions using miRWalk and TargetScan databases.
authors: Medical Faculty Mannheim, Medical Research Center, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, Mannheim, D-68167, Germany, harsh.dweep@medma.uni-heidelberg.de.
authors: Harsh
authors: H
authors: Dweep
authors: Norbert
authors: N
authors: Gretz
authors: Kyriakos
authors: K
authors: Felekkis
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000379:methods*; D056915:DNA Copy Number Variations / Q000235:genetics*; D030541:Databases, Genetic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D057188:Workflow
chemical_list: D035683:MicroRNAs