title: Application of high-strength biodegradable polyurethanes containing different ratios of biobased isomannide and poly (ϵ-caprolactone) diol.
abstract: Biodegradable-biocompatible polyurethanes were prepared with fixed hexamethylene diisocyanate and varying ratios of isomannide and poly(ϵ-caprolactone) diol using a simple one-step polymerization without a catalyst. The polyurethane structures were confirmed by1H-nuclear magnetic resonance, Fourier transform infrared spectroscopy, and gel permeation chromatography. The glass transition temperatures were determined by thermal analysis to be between 25°C and 30°C. Degradation tests performed at 37°C in phosphate buffer produced mass losses of 5%-10% after 8 weeks. After 5 days of culture, using osteoblastic cells, the relative cell number on all the polyurethane films was only slightly lower than that of an optimized tissue culture plastic. These polymers offer significant promise with a simplistic synthesis and controlled degradation.
authors: Department of Nanobiomedical Science & WCU Research Center, Graduate School, Dankook University, Cheonan, South Korea.
authors: Dong-In
authors: DI
authors: Lim
authors: Department of Nanobiomedical Science & WCU Research Center, Graduate School, Dankook University, Cheonan, South Korea.
authors: Hyung-Seok
authors: HS
authors: Park
authors: Department of Nanobiomedical Science & WCU Research Center, Graduate School, Dankook University, Cheonan, South Korea.
authors: Jeong-Hui
authors: JH
authors: Park
authors: Department of Nanobiomedical Science & WCU Research Center, Graduate School, Dankook University, Cheonan, South Korea ; Department of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, London, UK.
authors: Jonathan C
authors: JC
authors: Knowles
authors: Department of Nanobiomedical Science & WCU Research Center, Graduate School, Dankook University, Cheonan, South Korea.
authors: Myoung-Seon
authors: MS
authors: Gong
keywords: Biodegradable; biobased monomer; biocompatible; isomannide; polyurethane