title: 20 years of leptin: insights into signaling assemblies of the leptin receptor.
abstract: Leptin plays a central role in the control of body weight and energy homeostasis, but is a pleiotropic cytokine with activities on many peripheral cell types. In this review, we discuss the interaction of leptin with its receptor, and focus on the structural and mechanistic aspects of the extracellular aspects of leptin receptor (LR) activation. We provide an extensive overview of all structural information that has been obtained for leptin and its receptor via X-ray crystallography, electron microscopy, small-angle X-ray scattering, homology modeling, and mutagenesis studies. The available knowledge is integrated into putative models toward a recapitulation of the LR activation mechanism.
authors: Department of Medical Protein ResearchFaculty of Medicine and Health Sciences, Flanders Institute for Biotechnology (VIB), Ghent University, A. Baertsoenkaai 3, 9000 Ghent, BelgiumUnit for Structural BiologyLaboratory for Protein Biochemistry and Biomolecular Engineering (L-ProBE), Ghent University, K.L. Ledeganckstraat 35, 9000 Ghent, Belgium.
authors: Frank
authors: F
authors: Peelman
authors: Department of Medical Protein ResearchFaculty of Medicine and Health Sciences, Flanders Institute for Biotechnology (VIB), Ghent University, A. Baertsoenkaai 3, 9000 Ghent, BelgiumUnit for Structural BiologyLaboratory for Protein Biochemistry and Biomolecular Engineering (L-ProBE), Ghent University, K.L. Ledeganckstraat 35, 9000 Ghent, Belgium.
authors: Lennart
authors: L
authors: Zabeau
authors: Department of Medical Protein ResearchFaculty of Medicine and Health Sciences, Flanders Institute for Biotechnology (VIB), Ghent University, A. Baertsoenkaai 3, 9000 Ghent, BelgiumUnit for Structural BiologyLaboratory for Protein Biochemistry and Biomolecular Engineering (L-ProBE), Ghent University, K.L. Ledeganckstraat 35, 9000 Ghent, Belgium.
authors: Kedar
authors: K
authors: Moharana
authors: Department of Medical Protein ResearchFaculty of Medicine and Health Sciences, Flanders Institute for Biotechnology (VIB), Ghent University, A. Baertsoenkaai 3, 9000 Ghent, BelgiumUnit for Structural BiologyLaboratory for Protein Biochemistry and Biomolecular Engineering (L-ProBE), Ghent University, K.L. Ledeganckstraat 35, 9000 Ghent, Belgium.
authors: Savvas N
authors: SN
authors: Savvides
authors: Department of Medical Protein ResearchFaculty of Medicine and Health Sciences, Flanders Institute for Biotechnology (VIB), Ghent University, A. Baertsoenkaai 3, 9000 Ghent, BelgiumUnit for Structural BiologyLaboratory for Protein Biochemistry and Biomolecular Engineering (L-ProBE), Ghent University, K.L. Ledeganckstraat 35, 9000 Ghent, Belgium jan.tavernier@vib-ugent.be.
authors: Jan
authors: J
authors: Tavernier
mesh_terms: D000595:Amino Acid Sequence; D006801:Humans; D020738:Leptin / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D054411:Receptors, Leptin / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction
chemical_list: D020738:Leptin; D054411:Receptors, Leptin
keywords: leptin; leptin receptor; modeling; structure