title: Towards the Development of Smart 3D "gated scaffolds" for on-command delivery.
abstract: A new approach towards the design of "gated scaffolds" based on the combination of capped mesoporous silica nanoparticles (MSNs) with porous biomaterials is reported. Using this approach, a 3D gelatin-based scaffold able to selectively deliver cargo in the presence of an APase enzyme is prepared and tested. This new design opens up the possibility of developing new smart biomaterials with advanced drug-delivery features.
authors: Centro de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Unidad Mixta Universitat de València-Universitat Politècnica de València and Departamento de Química, Camino de Vera s/n, 46022, Valencia, Spain and CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Spain.
authors: Núria
authors: N
authors: Mas
authors: Daniel
authors: D
authors: Arcos
authors: Lorena
authors: L
authors: Polo
authors: Elena
authors: E
authors: Aznar
authors: Sandra
authors: S
authors: Sánchez-Salcedo
authors: Félix
authors: F
authors: Sancenón
authors: Ana
authors: A
authors: García
authors: M Dolores
authors: MD
authors: Marcos
authors: Alejandro
authors: A
authors: Baeza
authors: María
authors: M
authors: Vallet-Regí
authors: Ramón
authors: R
authors: Martínez-Máñez
mesh_terms: D000255:Adenosine Triphosphate / Q000737:chemistry; D000838:Anions; D001672:Biocompatible Materials / Q000737:chemistry*; D004337:Drug Carriers; D016503:Drug Delivery Systems; D005782:Gels / Q000737:chemistry; D006860:Hydrogen Bonding; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods; D016062:Porosity; D012038:Regeneration; D012822:Silicon Dioxide / Q000737:chemistry; D023822:Tissue Engineering / Q000379:methods; D014961:X-Ray Diffraction
chemical_list: D000838:Anions; D001672:Biocompatible Materials; D004337:Drug Carriers; D005782:Gels; D012822:Silicon Dioxide; D000255:Adenosine Triphosphate
keywords: 3D scaffolds; biomaterials; controlled release; mesoporous silica nanoparticles