title: Receptors of hypothalamic-pituitary-ovarian-axis hormone in uterine myomas.
abstract: In this study the expression of GnRH, FSH, LH, ER-α, ER-β, and PR receptors was examined in uterine myomas of women in reproductive and perimenopausal age. In cases of GnRH and tropic hormones a membranous and cytoplasmic immunohistochemical reaction was detected, in cases of ER-α and PR the reaction was located in cell nucleus, and in the case of ER-β it manifested also a cytoplasmic location. In some of the examined cases the expression was detected in endometrium, myocytes, and endothelium of blood vessels, in uterine glands and myoma cells. In myometrium the level of GnRH and LH receptors increases with age, whereas the level of progesterone and both estrogen receptors decreases. In myomas of women in reproductive age, independently of their size, expression of GnRH, FSH, and LH receptors was more pronounced than in myometrium. In women of perimenopausal age, independently of myoma size, expression of LH and estrogen α receptors was higher while expression of GnRH receptors was lower than in myometrium. FSH receptor expression was not observed. Expression of estrogen receptor β was not affected by age of the woman or size of myoma. Analysis of obtained results indicates on existing in small myomas local feedback axis between GnRH-LH-progesterone.
authors: Department of Cytophysiology, Chair of Histology and Embryology, Medical University of Silesia, Medykow 18 Street, 40-752 Katowice, Poland.
authors: Danuta
authors: D
authors: Plewka
authors: Department of Proteomics, Medical University of Silesia, Jednosci Street 8, 41-200 Sosnowiec, Poland.
authors: Jacek
authors: J
authors: Marczyński
authors: Department of Proteomics, Medical University of Silesia, Jednosci Street 8, 41-200 Sosnowiec, Poland.
authors: Michał
authors: M
authors: Morek
authors: Department of Proteomics, Medical University of Silesia, Jednosci Street 8, 41-200 Sosnowiec, Poland.
authors: Edyta
authors: E
authors: Bogunia
authors: Department of Proteomics, Medical University of Silesia, Jednosci Street 8, 41-200 Sosnowiec, Poland.
authors: Andrzej
authors: 0000-0001-7129-9490
authors: A
authors: Plewka
mesh_terms: D047628:Estrogen Receptor alpha / Q000378:metabolism; D047629:Estrogen Receptor beta / Q000378:metabolism; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism*; D007150:Immunohistochemistry; D007889:Leiomyoma / Q000378:metabolism* / Q000473:pathology; D008875:Middle Aged; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011962:Receptors, FSH / Q000378:metabolism; D011974:Receptors, LH / Q000378:metabolism; D011966:Receptors, LHRH / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D014594:Uterine Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D011956:Receptors, Cell Surface; D011962:Receptors, FSH; D011974:Receptors, LH; D011966:Receptors, LHRH; D011980:Receptors, Progesterone