title: Azapropellanes with anti-influenza a virus activity.
abstract: The synthesis of several [4,4,3], [4,3,3], and [3,3,3]azapropellanes is reported. Several of the novel amines displayed low-micromolar activities against an amantadine-resistant H1N1 strain, but they did not show activity against an amantadine-sensitive H3N2 strain. None of the tested compounds inhibit the influenza A/M2 proton channel function. Most of the compounds did not show cytotoxicity for MDCK cells.
authors: Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia, and Institute of Biomedicine (IBUB), Universitat de Barcelona , Av. Diagonal 643, Barcelona E-08028, Spain.
authors: Eva
authors: E
authors: Torres
authors: Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia, and Institute of Biomedicine (IBUB), Universitat de Barcelona , Av. Diagonal 643, Barcelona E-08028, Spain.
authors: Rosana
authors: R
authors: Leiva
authors: Department of Biosciences and National Research Council (CNR) Biophysics Institute (IBF), University of Milan , Via Celoria 26, 20133 Milan, Italy.
authors: Sabrina
authors: S
authors: Gazzarrini
authors: Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia, and Institute of Biomedicine (IBUB), Universitat de Barcelona , Av. Diagonal 643, Barcelona E-08028, Spain.
authors: Matías
authors: M
authors: Rey-Carrizo
authors: Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia, and Institute of Biomedicine (IBUB), Universitat de Barcelona , Av. Diagonal 643, Barcelona E-08028, Spain.
authors: Marta
authors: M
authors: Frigolé-Vivas
authors: Department of Biosciences and National Research Council (CNR) Biophysics Institute (IBF), University of Milan , Via Celoria 26, 20133 Milan, Italy.
authors: Anna
authors: A
authors: Moroni
authors: Rega Institute for Medical Research, KU Leuven , 3000 Leuven, Belgium.
authors: Lieve
authors: L
authors: Naesens
authors: Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia, and Institute of Biomedicine (IBUB), Universitat de Barcelona , Av. Diagonal 643, Barcelona E-08028, Spain.
authors: Santiago
authors: S
authors: Vázquez
keywords: Amantadine; M2 channel; hemagglutinin; influenza; propellane