title: Anticancer Tc9 cells: Long-lived tumor-killing T cells for adoptive therapy.
abstract: IL-9-producing cytotoxic T (Tc9) cells represent a unique CD8+T-cell subset. These long-lived immune cells possess the capacity to acquire effector function and home to tumor tissues after adoptive transfer. IL-9 is indispensable for Tc9-mediated superior antitumor response. These findings are highly significant and crucial to achieve advances in T cell-based adoptive therapies.
authors: Department of Cancer Biology; Lerner Research Institute; Cleveland Clinic; Cleveland, OH USA.
authors: Yong
authors: Y
authors: Lu
authors: Department of Cancer Biology; Lerner Research Institute; Cleveland Clinic; Cleveland, OH USA.
authors: Qiang
authors: Q
authors: Wang
authors: Department of Cancer Biology; Lerner Research Institute; Cleveland Clinic; Cleveland, OH USA.
authors: Qing
authors: Q
authors: Yi
keywords: IL-9; Tc9 cells; cancer adoptive cell therapy; effector cell conversion; exhaustion