title: Synthesis, structures, and selective toxicity to cancer cells of gold(I) complexes involving N-heterocyclic carbene ligands.
abstract: New gold(I) complexes containing two 1-[2-(diethylamino)ethyl]imidazolydene ligands have been synthesized and characterized. The X-ray structures of two key compounds are presented. All complexes have been tested for their antiproliferative activities in prostate cancer cell line PC-3. Lipophilicity (Log P) has been determined for these complexes. The most active complex has been tested for the cytotoxic activities in five human cancer cell lines and primary endothelial cells. The most active complex demonstrated a potent selectivity for cancer cells.
authors: CNRS, LCC (Laboratoire de Chimie de Coordination), 205 route de Narbonne, BP 44099, F-31077 Toulouse cedex 4, France; Université de Toulouse, UPS, INP, LCC, F-31077 Toulouse, France.
authors: Luca
authors: L
authors: Boselli
authors: CNRS, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France; Université de Toulouse, UPS, IPBS, Toulouse, France.
authors: Isabelle
authors: I
authors: Ader
authors: Université de Toulouse, UPS, UMR 152 Pharma-DEV, Université Toulouse 3, Faculté des sciences pharmaceutiques, 35 Chemin des maraîchers, F-31062 Toulouse cedex 9, France; Institut de Recherche pour le Développement, IRD, UMR 152 Pharma-DEV, F-31062 Toulouse cedex 9, France.
authors: Maëlle
authors: M
authors: Carraz
authors: CNRS, LCC (Laboratoire de Chimie de Coordination), 205 route de Narbonne, BP 44099, F-31077 Toulouse cedex 4, France; Université de Toulouse, UPS, INP, LCC, F-31077 Toulouse, France. Electronic address: hemmert@lcc.toulouse.fr.
authors: Catherine
authors: C
authors: Hemmert
authors: CNRS, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France; Université de Toulouse, UPS, IPBS, Toulouse, France. Electronic address: olivier.cuvillier@inserm.fr.
authors: Olivier
authors: O
authors: Cuvillier
authors: CNRS, LCC (Laboratoire de Chimie de Coordination), 205 route de Narbonne, BP 44099, F-31077 Toulouse cedex 4, France; Université de Toulouse, UPS, INP, LCC, F-31077 Toulouse, France. Electronic address: gornitzka@lcc.toulouse.fr.
authors: Heinz
authors: H
authors: Gornitzka
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D060326:Chemistry Techniques, Synthetic; D006046:Gold / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006801:Humans; D008024:Ligands; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D006571:Heterocyclic Compounds; D008024:Ligands; D009942:Organometallic Compounds; C030011:carbene; D006046:Gold; D008697:Methane
keywords: Cancer; Carbene ligands; Gold; HUVEC; Lipophilicity