title: Catalytic asymmetric Torgov cyclization: a concise total synthesis of (+)-estrone.
abstract: An asymmetric Torgov cyclization, catalyzed by a novel, highly Brønsted acidic dinitro-substituted disulfonimide, is described. The reaction delivers the Torgov diene and various analogues with excellent yields and enantioselectivity. This method was applied in a very short synthesis of (+)-estrone.
authors: Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470, Mülheim an der Ruhr (Germany).
authors: Sébastien
authors: S
authors: Prévost
authors: Nathalie
authors: N
authors: Dupré
authors: Markus
authors: M
authors: Leutzsch
authors: Qinggang
authors: Q
authors: Wang
authors: Vijay
authors: V
authors: Wakchaure
authors: Benjamin
authors: B
authors: List
mesh_terms: D000143:Acids / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D004970:Estrone / Q000138:chemical synthesis* / Q000737:chemistry; D007094:Imides / Q000737:chemistry; D013237:Stereoisomerism; D013450:Sulfones / Q000737:chemistry
chemical_list: D000143:Acids; D007094:Imides; D013450:Sulfones; D004970:Estrone
keywords: disulfonimides; estrone; organocatalysis; torgov cyclization; total synthesis