title: [Genotype-phenotype characteristics of biochemical markers of endothelial dysfunction in patients with chronic mercury intoxication].
abstract: The paper presents data on the frequency of polymorphisms of candidate genes involved in the formation of endothelial dysfunction--endothelin-1 (EDN1 Lys198Asn) and endothelial nitric oxide synthase (NOS3 T786C) together with the concentrations of their active products (nitric oxide, endothelin-1) in individuals with chronic mercury intoxication. The concentration change of nitric oxide and endothelin-1 indicates the presence of endothelial dysfunction in the individuals examined. The studied polymorphisms appeared to play a minor role in the pathogenesis of endothelial dysfunction in patients with chronic mercury intoxication.
authors: O V
authors: OV
authors: Popkova
authors: I V
authors: IV
authors: Kudaeva
authors: L B
authors: LB
authors: Masnavieva
authors: V P
authors: VP
authors: Belik
mesh_terms: D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D019332:Endothelin-1 / Q000097:blood / Q000235:genetics*; D004727:Endothelium / Q000503:physiopathology; D005838:Genotype; D006801:Humans; D008297:Male; D008630:Mercury Poisoning / Q000097:blood / Q000235:genetics*; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood / Q000378:metabolism*; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D009784:Occupational Diseases / Q000097:blood* / Q000235:genetics; D016273:Occupational Exposure / Q000009:adverse effects*; D010641:Phenotype; D011110:Polymorphism, Genetic
chemical_list: D015415:Biomarkers; D019332:Endothelin-1; D009569:Nitric Oxide; C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III