title: Fatal primary meningoencephalitis caused by Naegleria fowleri.
abstract: Naegleria fowleri is a free living parasite which habitats in fresh water reservoirs. It causes a fatal nervous system infection known as primary amoebic meningoencephalitis by invading through cribriform plate of nose and gaining entry into brain. We report a case of primary amoebic meningoencephalitis caused by Naegleria fowleri in Karachi, Pakistan, in a 42 years old male poultry farm worker having no history of swimming. Clinical course was fulminant and death occurred within one week of hospital admission. Naegleria fowleri was detected by wet mount technique in the sample of cerebrospinal fluid collected by lumbar puncture of patient. This is a serious problem and requires immediate steps to prevent general population to get affected by this lethal neurological infection.
authors: Department of Microbiology, Dr. Ziauddin University Hospital, North Nazimabad Campus, Karachi.
authors: Ali
authors: A
authors: Shariq
authors: Department of Microbiology, Dr. Ziauddin University Hospital, North Nazimabad Campus, Karachi.
authors: Faisal Iqbal
authors: FI
authors: Afridi
authors: Department of Microbiology, Dr. Ziauddin University Hospital, North Nazimabad Campus, Karachi.
authors: Badar Jahan
authors: BJ
authors: Farooqi
authors: Department of Medicine and Allied, Dr. Ziauddin University Hospital, North Nazimabad Campus, Karachi.
authors: Sumaira
authors: S
authors: Ahmed
authors: Department of Microbiology, Dr. Ziauddin University Hospital, North Nazimabad Campus, Karachi.
authors: Arif
authors: A
authors: Hussain
mesh_terms: D000328:Adult; D000562:Amebiasis / Q000175:diagnosis* / Q000188:drug therapy; D000563:Amebicides / Q000008:administration & dosage / Q000627:therapeutic use; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use; D020808:Central Nervous System Protozoal Infections / Q000175:diagnosis* / Q000188:drug therapy; D003907:Dexamethasone / Q000008:administration & dosage / Q000627:therapeutic use; D017809:Fatal Outcome; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D008297:Male; D016848:Naegleria fowleri / Q000302:isolation & purification*; D010154:Pakistan
chemical_list: D000563:Amebicides; D005938:Glucocorticoids; D003907:Dexamethasone; D000666:Amphotericin B