title: Effect of gastric acid suppressants and prokinetics on peritoneal dialysis-related peritonitis.
abstract: OBJECTIVE
  To investigate the effect of gastric acid suppressants and prokinetics on peritonitis development in peritoneal dialysis (PD) patients.
  
  
  METHODS
  This was a single-center, retrospective study. The medical records of 398 PD patients were collected from January 2000 to September 2012 and analyzed to compare patients with at least one episode of peritonitis (peritonitis group, group A) to patients who never had peritonitis (no peritonitis group, group B). All peritonitis episodes were analyzed to compare peritonitis caused by enteric organisms and peritonitis caused by non-enteric organisms.
  
  
  RESULTS
  Among the 120 patients who met the inclusion criteria, 61 patients had at least one episode of peritonitis and 59 patients never experienced peritonitis. Twenty-four of 61 patients (39.3%) in group A and 15 of 59 patients (25.4%) in group B used gastric acid suppressants. Only the use of H2-blocker (H2B) was associated with an increased risk of PD-related peritonitis; the use of proton pump inhibitors, other antacids, and prokinetics was not found to be a significant risk factor for PD-related peritonitis. A total of 81 episodes of peritonitis were divided into enteric peritonitis (EP) or non-enteric peritonitis, depending on the causative organism, and gastric acid suppressants and prokinetics did not increase the risk of EP in PD patients.
  
  
  CONCLUSIONS
  The use of H2B showed a trend for an increased risk of overall PD-related peritonitis, although further studies are required to clarify the effects of drugs on PD-related peritonitis.
authors: Ji Eun Kwon, Jaeyoung Chun, Jong Pil Im, Joo Sung Kim, Hyun Chae Jung, Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul 110-799, South Korea.
authors: Ji Eun
authors: JE
authors: Kwon
authors: Ji Eun Kwon, Jaeyoung Chun, Jong Pil Im, Joo Sung Kim, Hyun Chae Jung, Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul 110-799, South Korea.
authors: Seong-Joon
authors: SJ
authors: Koh
authors: Ji Eun Kwon, Jaeyoung Chun, Jong Pil Im, Joo Sung Kim, Hyun Chae Jung, Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul 110-799, South Korea.
authors: Jaeyoung
authors: J
authors: Chun
authors: Ji Eun Kwon, Jaeyoung Chun, Jong Pil Im, Joo Sung Kim, Hyun Chae Jung, Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul 110-799, South Korea.
authors: Ji Won
authors: JW
authors: Kim
authors: Ji Eun Kwon, Jaeyoung Chun, Jong Pil Im, Joo Sung Kim, Hyun Chae Jung, Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul 110-799, South Korea.
authors: Byeong Gwan
authors: BG
authors: Kim
authors: Ji Eun Kwon, Jaeyoung Chun, Jong Pil Im, Joo Sung Kim, Hyun Chae Jung, Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul 110-799, South Korea.
authors: Kook Lae
authors: KL
authors: Lee
authors: Ji Eun Kwon, Jaeyoung Chun, Jong Pil Im, Joo Sung Kim, Hyun Chae Jung, Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul 110-799, South Korea.
authors: Jong Pil
authors: JP
authors: Im
authors: Ji Eun Kwon, Jaeyoung Chun, Jong Pil Im, Joo Sung Kim, Hyun Chae Jung, Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul 110-799, South Korea.
authors: Joo Sung
authors: JS
authors: Kim
authors: Ji Eun Kwon, Jaeyoung Chun, Jong Pil Im, Joo Sung Kim, Hyun Chae Jung, Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul 110-799, South Korea.
authors: Hyun Chae
authors: HC
authors: Jung
mesh_terms: D000328:Adult; D000368:Aged; D000863:Antacids / Q000009:adverse effects*; D005260:Female; D005765:Gastrointestinal Agents / Q000009:adverse effects*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D041981:Gastrointestinal Tract / Q000187:drug effects* / Q000382:microbiology / Q000503:physiopathology; D006635:Histamine H2 Antagonists / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D010538:Peritonitis / Q000209:etiology* / Q000382:microbiology / Q000503:physiopathology; D054328:Proton Pump Inhibitors / Q000009:adverse effects; D056910:Republic of Korea; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D055815:Young Adult
chemical_list: D000863:Antacids; D005765:Gastrointestinal Agents; D006635:Histamine H2 Antagonists; D054328:Proton Pump Inhibitors
keywords: Gastrointestinal motility; Histamine 2 receptor antagonists; Peritoneal dialysis; Peritonitis; Proton pump inhibitors