title: Brain BDNF levels elevation induced by physical training is reduced after unilateral common carotid artery occlusion in rats.
abstract: We investigated the contribution of blood flow elevation in the cerebrovasculature to physical training-induced brain-derived neurotrophic factor (BDNF) levels elevation in the brain. Brain-derived neurotrophic factor protein levels were measured in the motor cortex 24 h after the last session of a forced treadmill walking (30 minutes a day, 18 m/minute for 7 consecutive days). Unilateral common carotid artery occlusion and modulation of exercise intensity (0 versus -10% inclination of the treadmill) were used as strategies to reduce the (normal) elevation of flow in the cerebrovasculature occurring during exercise. Administration of N-nitro-L-arginine methyl ester (L-NAME, 60 mg/kg before each exercise sessions) and genetic hypertension (spontaneously hypertensive rats) were used as approaches to reduce stimulation of nitric oxide production in response to shear stress elevation. Vascular occlusion totally and partially abolished the effect of physical training on BDNF levels in the hemisphere ipsilateral and contralateral to occlusion, respectively. BDNF levels were higher after high than low exercise intensity. In addition, both genetic hypertension and L-NAME treatment blunted the effects of physical training on BDNF. From these results, we propose that elevation of brain BDNF levels elicited by physical training involves changes in cerebral hemodynamics.
authors: Unité INSERM U1093 Cognition, Action et Plasticité Sensorimotrice, Université de Bourgogne, Dijon, France.
authors: Hayat
authors: H
authors: Banoujaafar
authors: Unité INSERM U1093 Cognition, Action et Plasticité Sensorimotrice, Université de Bourgogne, Dijon, France.
authors: Jacques
authors: J
authors: Van Hoecke
authors: Unité INSERM U1093 Cognition, Action et Plasticité Sensorimotrice, Université de Bourgogne, Dijon, France.
authors: Claude M
authors: CM
authors: Mossiat
authors: Unité INSERM U1093 Cognition, Action et Plasticité Sensorimotrice, Université de Bourgogne, Dijon, France.
authors: Christine
authors: C
authors: Marie
mesh_terms: D000818:Animals; D001157:Arterial Occlusive Diseases / Q000378:metabolism* / Q000503:physiopathology; D001921:Brain / Q000098:blood supply* / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D019208:Brain-Derived Neurotrophic Factor / Q000032:analysis / Q000378:metabolism*; D017536:Carotid Artery, Common / Q000378:metabolism* / Q000503:physiopathology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006439:Hemodynamics; D006973:Hypertension / Q000235:genetics / Q000378:metabolism; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009569:Nitric Oxide / Q000378:metabolism; D010805:Physical Conditioning, Animal; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D004791:Enzyme Inhibitors; D009569:Nitric Oxide; D019331:NG-Nitroarginine Methyl Ester