title: Postprandial response of bone turnover markers in patients with Crohn's disease.
abstract: OBJECTIVE
  To investigate the postprandial response of bone turnover markers in patients with Crohn's disease (CD).
  
  
  METHODS
  Fifty nine patients with CD aged 38 ± 14 years, and 45 healthy individuals matched for age and body mass index were included in the study. All participants underwent an oral glucose tolerance test (OGTT) after an overnight fast and serum levels of the bone resorption marker C-terminal crosslinking telopeptide of type I collagen (CTX-I) and the bone formation marker procollagen type I N propeptide were measured. Activity of the disease was assessed by calculation of the Crohn's disease activity index (CDAI).
  
  
  RESULTS
  Serum CTX-I was significantly higher in patients compared to controls (CTX-I: 453 ± 21 pg/mL vs 365 ± 25 pg/mL, P = 0.008), and values were significantly correlated with the activity of the disease (r = 0.435, P = 0.001). Results from OGTT-induced suppression of CTX-I showed two different trends. Patients with more active disease (assessed as CDAI > 150) had a more excessive suppression of CTX-I compared to controls (55% vs 43% P < 0.001), while patients on remission (assessed as CDAI < 150) demonstrated an attenuated CTX-I suppression (30% vs 43% P < 0.001). In line with this, CTX-I suppression after oral glucose load was significantly correlated with the activity of the disease (r = 0.913, P < 0.001).
  
  
  CONCLUSIONS
  The physiological skeletal response of postprandial suppression of bone resorption is maintained in patients with CD and is strongly dependent to the activity of the disease.
authors: Ioannis Karatzoglou, Maria Pikilidou, George Germanidis, Michael Daniilidis, Pantelis Zebekakis, 1 Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
authors: Ioannis
authors: I
authors: Karatzoglou
authors: Ioannis Karatzoglou, Maria Pikilidou, George Germanidis, Michael Daniilidis, Pantelis Zebekakis, 1 Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
authors: Maria P
authors: MP
authors: Yavropoulou
authors: Ioannis Karatzoglou, Maria Pikilidou, George Germanidis, Michael Daniilidis, Pantelis Zebekakis, 1 Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
authors: Maria
authors: M
authors: Pikilidou
authors: Ioannis Karatzoglou, Maria Pikilidou, George Germanidis, Michael Daniilidis, Pantelis Zebekakis, 1 Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
authors: George
authors: G
authors: Germanidis
authors: Ioannis Karatzoglou, Maria Pikilidou, George Germanidis, Michael Daniilidis, Pantelis Zebekakis, 1 Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
authors: Evangelos
authors: E
authors: Akriviadis
authors: Ioannis Karatzoglou, Maria Pikilidou, George Germanidis, Michael Daniilidis, Pantelis Zebekakis, 1 Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
authors: Alexandra
authors: A
authors: Papazisi
authors: Ioannis Karatzoglou, Maria Pikilidou, George Germanidis, Michael Daniilidis, Pantelis Zebekakis, 1 Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
authors: Michael
authors: M
authors: Daniilidis
authors: Ioannis Karatzoglou, Maria Pikilidou, George Germanidis, Michael Daniilidis, Pantelis Zebekakis, 1 Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
authors: Pantelis
authors: P
authors: Zebekakis
authors: Ioannis Karatzoglou, Maria Pikilidou, George Germanidis, Michael Daniilidis, Pantelis Zebekakis, 1 Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
authors: John G
authors: JG
authors: Yovos
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016723:Bone Remodeling; D016022:Case-Control Studies; D024042:Collagen Type I / Q000097:blood*; D003424:Crohn Disease / Q000097:blood* / Q000175:diagnosis / Q000628:therapy; D015536:Down-Regulation; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood*; D010455:Peptides / Q000097:blood*; D019518:Postprandial Period; D011347:Procollagen / Q000097:blood*; D012074:Remission Induction; D012720:Severity of Illness Index; D013997:Time Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; C052929:collagen type I trimeric cross-linked peptide; C047202:procollagen Type I N-terminal peptide
keywords: Bone metabolism; C-terminal crosslinking telopeptide of type I collagen; Crohn’s disease; Oral glucose tolerance test; Postprandial bone resorption