title: High-sensitivity C-reactive protein as a novel marker in early diagnosis of ovarian torsion: an experimental study.
abstract: OBJECTIVE
  To investigate the effect of ovarian torsion on plasma high-sensitivity C reactive protein (hs-CRP) levels and to determine whether hs-CRP levels were a useful adjunct that could be used in the diagnosis of ovarian torsion.
  
  
  METHODS
  Sixteen nulligravid 4-month-old female Wistar albino rats were randomly and equally allocated into two groups. Control group, sham operation (n = 8) group, and study group, ovarian torsion (n = 8) group. Ovarian torsion model was created using titanium vascular clips and vascular clips were kept for a 2-h period. Right ovaries were surgically removed at the end of the procedure in each group. Blood was sampled before and after operation to assess plasma hs-CRP levels. Ovarian histopathologic findings scores and plasma hs-CRP levels were evaluated.
  
  
  RESULTS
  In study group, the mean plasma hs-CRP level was significantly higher than that in the control group. (0.91 ± 0.18 vs. 0.39 ± 0.06 mg/l, respectively, p < 0.001), following 2 h of ovarian torsion. Histologic examinations of the right ovary confirmed the torsion model. Histologic score of the specimens had higher scores for follicular cell degeneration (p = 0.002), vascular congestion (p = 0.002), inflammatory cell infiltration (p = 0.003), and hemorrhage (p < 0.001) in the study group. For the change in the plasma hs-CRP value for a cut-off value of >0.275 mg/l, sensitivity and specificity were calculated as 100 %.
  
  
  CONCLUSIONS
  The measurement of hs-CRP in a rat model seems to be a valuable plasma marker in early detection and diagnosis of ovarian torsion. However, further clinical and experimental studies of a larger size are required.
authors: Department of Obstetrics and Gynecology, School of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaraş, Turkey, muratbakacak46@gmail.com.
authors: Murat
authors: M
authors: Bakacak
authors: Bülent
authors: B
authors: Köstü
authors: Önder
authors: Ö
authors: Ercan
authors: Mehmet Sühha
authors: MS
authors: Bostancı
authors: Gürkan
authors: G
authors: Kıran
authors: Murat
authors: M
authors: Aral
authors: Harun
authors: H
authors: Çıralık
authors: Salih
authors: S
authors: Serin
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D042241:Early Diagnosis; D005260:Female; D010049:Ovarian Diseases / Q000175:diagnosis* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D014102:Torsion Abnormality / Q000175:diagnosis* / Q000473:pathology
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein