title: Relationship between cardio-ankle vascular index and N-terminal pro-brain natriuretic peptide in hypertension and coronary heart disease subjects.
abstract: Arterial stiffness is an independent predictor for vascular diseases. Cardio-ankle vascular index (CAVI) is a new index of arterial stiffness. N-terminal pro-brain natriuretic peptide (NT-proBNP) is a strong prognostic marker in advanced stage of coronary heart disease (CHD). In the present study, we investigated the relationship between CAVI and NT-proBNP in hypertension and CHD subjects. Five hundred one subjects (male/female, 209/292) from Vascular Medicine of Peking University Shougang Hospital were divided into four groups: healthy group (n = 186), hypertension group (n = 159), CHD group (n = 45), and hypertension with CHD group (n = 111). CAVI was measured using VS-1000 apparatus. Our results showed that CAVI was significantly higher in hypertension subjects with CHD than in healthy and hypertension group, respectively (8.42 ± 1.51 vs. 7.77 ± 1.19; 8.42 ± 1.51 vs. 7.92 ± 1.11; both P < .05). NT-proBNP was significantly higher in hypertension subjects with CHD than in healthy, hypertension, and CHD group, respectively (422.48 ± 761.60 vs. 174.29 ± 415.48; 422.48 ± 761.60 vs. 196.14 ± 299.16; 422.48 ± 761.60 vs. 209.66 ± 242.66; all P < .05). And after log transformation of NT-proBNP, this phenomenon also exists (2.32 ± 0.47 vs. 2.03 ± 0.40; 2.32 ± 0.47 vs. 2.09 ± 0.44; 2.32 ± 0.47 vs. 2.12 ± 0.42; all P < .05). There was positive correlation between log NT-proBNP and CAVI in the entire study group, healthy group, and nonhealthy group (r = 0.235, P < .001; r = 0.184, P = .023; r = 0.237, P < .001; respectively). Multivariate analysis showed that NT-proBNP was an independent associating factor of CAVI in all subjects (β = 0.150, P = .021). Our present study showed that CAVI and NT-proBNP were significantly higher in hypertension subjects with CHD compared with healthy and hypertension groups. There was significant correlation between NT-proBNP and CAVI, which indicates the relationship between arterial stiffness and biomarkers in vascular-related diseases.
authors: Department of Vascular Medicine, Peking University Shougang Hospital, Beijing, P. R. of China. Electronic address: hongyuwang@188.com.
authors: Hongyu
authors: H
authors: Wang
authors: Department of Vascular Medicine, Peking University Shougang Hospital, Beijing, P. R. of China.
authors: Jinbo
authors: J
authors: Liu
authors: Department of Vascular Medicine, Peking University Shougang Hospital, Beijing, P. R. of China.
authors: Hongwei
authors: H
authors: Zhao
authors: Department of Vascular Medicine, Peking University Shougang Hospital, Beijing, P. R. of China.
authors: Yingyan
authors: Y
authors: Zhou
authors: Department of Vascular Medicine, Peking University Shougang Hospital, Beijing, P. R. of China.
authors: Xujing
authors: X
authors: Zhao
authors: Department of Vascular Medicine, Peking University Shougang Hospital, Beijing, P. R. of China.
authors: Yuejie
authors: Y
authors: Song
authors: Department of Vascular Medicine, Peking University Shougang Hospital, Beijing, P. R. of China.
authors: Lihong
authors: L
authors: Li
authors: Department of Vascular Medicine, Peking University Shougang Hospital, Beijing, P. R. of China.
authors: Hongyan
authors: H
authors: Shi
mesh_terms: D000368:Aged; D000842:Ankle / Q000098:blood supply; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000502:physiology*; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011498:Protein Precursors; D012189:Retrospective Studies; D059289:Vascular Stiffness / Q000502:physiology*
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; D011498:Protein Precursors; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: Arterial stiffness; Biomarkers