title: Transcatheter arterial chemoembolization for intermediate-stage hepatocellular carcinoma: clinical outcome and safety in elderly patients.
abstract: OBJECTIVE
  The aim of our study was to compare clinical outcomes between elderly patients aged ≥75 years (elderly group, n=66) with intermediate hepatocellular carcinoma (HCC) undergoing transcatheter arterial chemoembolization (TACE) and younger patients aged <75 years (control group, n=84) with intermediate HCC undergoing TACE.
  
  
  METHODS
  Clinical outcomes, including overall survival (OS) and tumor response rate at initial therapy, were compared between these two groups.
  
  
  RESULTS
  The median survival time and the 1- and 3-year cumulative OS rates were 2.90 years and 84.1% and 48.0%, respectively, in the elderly group and 2.44 years and 78.2% and 39.3%, respectively, in the control group (p=0.887). The objective response rate in the elderly group was 81.8% (54/66 patients), while that in the control group was 78.6% (66/84 patients) (p=0.227).
  
  
  CONCLUSIONS
  Elderly patients with intermediate HCC undergoing TACE had a prognosis comparable with that of younger patients with intermediate HCC undergoing TACE.
authors: Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Osaka 543-0027, Japan.
authors: Hiroki
authors: H
authors: Nishikawa
authors: Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Osaka 543-0027, Japan.
authors: Ryuichi
authors: R
authors: Kita
authors: Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Osaka 543-0027, Japan.
authors: Toru
authors: T
authors: Kimura
authors: Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Osaka 543-0027, Japan.
authors: Yoshiaki
authors: Y
authors: Ohara
authors: Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Osaka 543-0027, Japan.
authors: Haruhiko
authors: H
authors: Takeda
authors: Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Osaka 543-0027, Japan.
authors: Azusa
authors: A
authors: Sakamoto
authors: Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Osaka 543-0027, Japan.
authors: Sumio
authors: S
authors: Saito
authors: Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Osaka 543-0027, Japan.
authors: Norihiro
authors: N
authors: Nishijima
authors: Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Osaka 543-0027, Japan.
authors: Akihiro
authors: A
authors: Nasu
authors: Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Osaka 543-0027, Japan.
authors: Hideyuki
authors: H
authors: Komekado
authors: Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Osaka 543-0027, Japan.
authors: Yukio
authors: Y
authors: Osaki
keywords: intermediate hepatocellular carcinoma; transcatheter arterial chemoembolization