title: Cubanes in medicinal chemistry: synthesis of functionalized building blocks.
abstract: A collection of novel, pharmaceutically relevant cubane-containing molecules has been prepared from the commercially available cubane-1,4-dimethylester. A range of synthetic methods have been applied to prepare these cubane building blocks with one or two functional handles to allow easy incorporation into existing medicinal chemistry programs.
authors: Oncology, Innovative Medicines, AstraZeneca , Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K.
authors: Joanna
authors: J
authors: Wlochal
authors: Robert D M
authors: RD
authors: Davies
authors: Jonathan
authors: J
authors: Burton
mesh_terms: D001952:Bridged-Ring Compounds / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D006571:Heterocyclic Compounds / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: D001952:Bridged-Ring Compounds; D006571:Heterocyclic Compounds