title: [Anti-NMDA receptor antibody in systemic lupus erythematosus].
abstract: N-Methyl-D-aspartate (NMDA) receptors are ligand-gated ion channels with crucial roles in synaptic transmission and central nervous system plasticity. Systemic lupus erythematosus (SLE) is a multi-system inflammatory disorder characterized by the presence of autoantibodies directed against double-stranded (ds) DNA. The pathophysiology of neuropsychiatric (NP) SLE is diverse and complicated. In SLE, anti-dsDNA antibody (Ab) cross-reacts with NMDA receptors. Serum anti-NMDA receptor Ab was found in 30% of SLE patients. We demonstrated the relationship between anti-NMDA receptor Ab and each organ's involvement in SLE, and the biological function of anti-NMDA receptor Ab. The frequency of NP-SLE was significantly higher in the anti-NMDA receptor Ab positive subset than the negative subset, although the frequencies of serositis and nephritis were not significant. Anti-NMDA receptor Ab titer inversely correlated with leukocyte counts and hemoglobin levels. Moreover, regarding to the effects of anti-NMDA receptor Ab on NMDA receptor-transfected cell viability and intracellular Ca2+ level, there was a significant inverse correlation between anti-NMDA receptor Ab titer and cell viability, and a significant association between anti-NMDA receptor Ab titer and intracellular Ca2+ level. In conclusion, anti-NMDA receptor Ab is associated with NP-SLE and cytopenia. Anti-NMDA receptor Ab could cause the injury of NMDA receptor-expressed cells by increasing Ca2+ influx.
authors: Takahisa
authors: T
authors: Gono
mesh_terms: D000818:Animals; D000974:Antibodies, Antinuclear / Q000627:therapeutic use*; D000941:Antigens / Q000276:immunology; D001323:Autoantibodies / Q000097:blood / Q000276:immunology / Q000627:therapeutic use*; D002118:Calcium / Q000378:metabolism; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology*
chemical_list: D000974:Antibodies, Antinuclear; D000941:Antigens; D001323:Autoantibodies; D016194:Receptors, N-Methyl-D-Aspartate; D002118:Calcium