title: Phylogenetic and temporal dynamics of human immunodeficiency virus type 1B in China: four types of B strains circulate in China.
abstract: To investigate the origin and evolutionary history of the spread of HIV-1 subtype B in China, a total of 409 sequences of pol gene sampled from 1994 to 2012 in 29 provinces across China was subjected to phylogenetic and Bayesian molecular clock analyses. The study reveals that subtype B strains in China are genetically diverse and can be classified into four distinct subgroups, namely B' (Thai-B), BJ-B (Beijing-B), Pan-B (Pandemic-B), and TW-B (Taiwan-B), according to the origin of the sequences. The BJ-B and TW-B are reported for the first time. Phylogeographic analysis reveals that B' exhibits a nationwide, transprovincial distribution, and is found in 21 provinces in China in this study, whereas the Pan-B, BJ-B, and TW-B lineages are restricted to particular regions. From the same common ancestor of B', there arise two subclusters in which sequences from Yunnan occupy the basal position. The times of the most recent common ancestors (tMRCAs) of B' and BJ-B are estimated to be 1983.6 (1975.9-1990.3) and 1995.3 (1989.6-2000.3), respectively. The skyline plot profile reveals an exponential decrease in median number of effective infections of subtype B in China from 1994 to 2009. The existence of four types of B clades also indicates distinct transmission networks of subtype B, originating from different introduction events at different time points. The data presented here offer a new perspective on the epidemic of HIV-1 subtype B in China.
authors: 1 Beijing Center for Disease Prevention and Control , Beijing, China .
authors: Jingrong
authors: J
authors: Ye
authors: Hongyan
authors: H
authors: Lu
authors: Xueli
authors: X
authors: Su
authors: Ruolei
authors: R
authors: Xin
authors: Lishi
authors: L
authors: Bai
authors: Ke
authors: K
authors: Xu
authors: Shuangqing
authors: S
authors: Yu
authors: Xia
authors: X
authors: Feng
authors: Hong
authors: H
authors: Yan
authors: Xiong
authors: X
authors: He
authors: Yi
authors: Y
authors: Zeng
mesh_terms: D002681:China; D006678:HIV / Q000145:classification* / Q000235:genetics; D006801:Humans; D058974:Phylogeography