title: [Features of bemithyl pharmacokinetics upon inhalation administration].
abstract: A comparative study of bemithyl pharmacokinetics was carried out upon its inhalation, intragastric and intravenous administration. The main drug metabolites were identified and the pharmacokinetic parameters were calculated. The obtained results suggest that the inhalation administration of bemithyl is a promising replacement for oral administration, which is related to high bioavailability of the drug and the absence of the effect of "first pass" through the liver.
authors: A F
authors: AF
authors: Kurpiakova
authors: D S
authors: DS
authors: Geĭbo
authors: V N
authors: VN
authors: Bykov
authors: A S
authors: AS
authors: Nikiforov
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D000927:Anticonvulsants / Q000493:pharmacokinetics* / Q000494:pharmacology*; D001562:Benzimidazoles / Q000493:pharmacokinetics* / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats
chemical_list: D000927:Anticonvulsants; D001562:Benzimidazoles; C049825:bemethyl