title: Multiple myeloma-associated amyloidoma of the sacrum: case report and review of the literature.
abstract: Study Design Case report. Objectives With only two previously reported cases, localized amyloidosis of the sacrum is extremely rare. Here we report a 64-year-old woman with a large osteolytic lesion accompanied by weakness and paresthesia of the right leg and difficulties in bladder control. Methods Fine needle biopsy and standard staging procedures revealed a primary solitary amyloidoma that was treated with intralesional resection, lumbopelvic stabilization, and consolidation radiotherapy. Results Clinical follow-up revealed the diagnosis of multiple myeloma 9 months after initial treatment. At 12 months, no local recurrence has occurred, the neurologic symptoms have resolved, and the systemic disease is in remission. Conclusions Intralesional resection with adjuvant radiotherapy of the amyloidoma achieved good local tumor control with limited morbidity.
authors: Department of Orthopaedic Surgery, Inselspital, Bern University Hospital, Bern, Switzerland.
authors: F M
authors: FM
authors: Klenke
authors: Department of Orthopaedic Surgery, Inselspital, Bern University Hospital, Bern, Switzerland.
authors: C
authors: C
authors: Wirtz
authors: Institute of Pathology, University of Bern, Bern, Switzerland.
authors: Y
authors: Y
authors: Banz
authors: Department of Orthopaedic Surgery, Inselspital, Bern University Hospital, Bern, Switzerland.
authors: M J B
authors: MJ
authors: Keel
authors: Department of Radiation Oncology, Inselspital, Bern University Hospital, Bern, Switzerland.
authors: N D
authors: ND
authors: Klass
authors: Department of Medical Oncology, Inselspital, Bern University Hospital, Bern, Switzerland.
authors: U
authors: U
authors: Novak
authors: Department of Orthopaedic Surgery, Inselspital, Bern University Hospital, Bern, Switzerland.
authors: L M
authors: LM
authors: Benneker
keywords: amyloidosis; multiple myeloma; radiation; sacrum; surgical treatment; tumor