title: Validation of a new static perimetric thresholding strategy (GATE).
abstract: OBJECTIVE
  To validate the EyeSuite version of German Adaptive Threshold Estimation (GATE), a new thresholding algorithm for automated static perimetry.
  
  
  METHODS
  Specification of agreement and its clinical evaluation as validation criteria. Comparison of local differential luminance sensitivity (DLS) and test time values between the prototype version of GATE (GATEp) and a clinical trial version, implemented in EyeSuite (GATEe), by means of modified Bland-Altman plots. All examinations were performed on the Octopus 900 perimeter (Haag-Streit Inc., Köniz, Switzerland). Visually impaired patients (anterior ischaemic optic neuropathy [n=3], glaucomatous optic neuropathy [n=15], (post-)chiasmal visual pathway lesion [n=6], retinitis pigmentosa [n=6]) were either tested with grid 30A (30° excentricity, 83 test locations) or grid 84NO (90° excentricity, 109 test locations, patients with RP only).
  
  
  RESULTS
  The comparison of local DLS values showed good-to-acceptable agreement between GATEp and GATEe (bias <2 dB, limits of agreement [LOA] <5 dB) and very good repeatability for GATEp (bias <0.5 dB, LOA<3 dB). Median test times for GATEp and GATEe were 7.8  and 8.8 min for the 30° grid and 6.7  and 7.8 min for the 90° grid.
  
  
  CONCLUSIONS
  GATEp and GATE, implemented in the commercially available EyeSuite software package (GATEe), show good agreement regarding local differential luminance sensitivity. GATEe can thus be also recommended for clinical practice.
  
  
  BACKGROUND
  NCT01265628.
authors: Department of Ophthalmology, University of Tübingen, Germany.
authors: Annette Franziska
authors: AF
authors: Luithardt
authors: Institute of Clinical Epidemiology and Applied Biometry, University of Tübingen, Tübingen, Germany.
authors: Christoph
authors: C
authors: Meisner
authors: Formerly Haag-Streit Inc., Köniz, Switzerland Carl Zeiss Meditec Inc., Feldbach, Switzerland.
authors: Matthias
authors: M
authors: Monhart
authors: Department of Ophthalmology, University of Tübingen, Germany.
authors: Elke
authors: E
authors: Krapp
authors: Department of Ophthalmology, University of Tübingen, Germany.
authors: Andrea
authors: A
authors: Mast
authors: Department of Ophthalmology, University of Tübingen, Germany Research Institute for Ophthalmology, University of Tübingen, Tübingen, Germany Faculty of Optics & Mechatronics, Competence Center "Vision Research", Study course "Ophthalmic Optics & Audiology", University of Applied Sciences, Aalen, Germany.
authors: Ulrich
authors: U
authors: Schiefer
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D005260:Female; D005901:Glaucoma / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D009897:Optic Chiasm / Q000473:pathology; D019574:Optic Nerve Neoplasms / Q000150:complications; D018917:Optic Neuropathy, Ischemic / Q000150:complications; D012174:Retinitis Pigmentosa / Q000150:complications; D012684:Sensory Thresholds; D014786:Vision Disorders / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D058609:Visual Field Tests / Q000379:methods* / Q000592:standards; D014794:Visual Fields / Q000502:physiology*; D055815:Young Adult
keywords: Diagnostic tests/Investigation; Field of vision; Glaucoma; Visual pathway