title: Evaluation and management of congenital bleeding disorders.
abstract: Patients presenting to the emergency department with acute bleeding and a history of clotting or platelet disorder present a unique challenge to the emergency physician. The severity of bleeding presentation is based on mechanism as well as factor levels: patients with factor levels greater than 5% can respond to most minor hemostatic challenges, whereas those with factor levels less than 1% bleed with minor trauma or even spontaneously. Treatment should be initiated in consultation with the patient's hematologist using medications and specific factor replacement, except in rare, life-threatening, resource-poor situations, when cryoprecipitate or activated prothrombin complex may be considerations.
authors: Department of Emergency Medicine, Georgetown University Hospital/Washington Hospital Center, 110 Irving Street Northwest, Washington, DC 20010, USA. Electronic address: rgbhat77@gmail.com.
authors: Rahul
authors: R
authors: Bhat
authors: Department of Emergency Medicine, Georgetown University Hospital/Washington Hospital Center, 110 Irving Street Northwest, Washington, DC 20010, USA.
authors: Whitney
authors: W
authors: Cabey
mesh_terms: D025861:Blood Coagulation Disorders, Inherited / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D001779:Blood Coagulation Factors / Q000627:therapeutic use*; D004636:Emergency Service, Hospital; D006470:Hemorrhage / Q000209:etiology*; D006801:Humans
chemical_list: D001779:Blood Coagulation Factors
keywords: Bleeding; Coagulopathy; Congenital; Factor; Hemophilia; Platelet dysfunction; von Willebrand