title: Vitamin D protects against diet-induced obesity by enhancing fatty acid oxidation.
abstract: Prospective studies reported an inverse correlation between 25-hydroxyvitamin D [25(OH)D] plasma levels and prevalence of obesity and type 2 diabetes. In addition, 25(OH)D status may be a determinant of obesity onset. However, the causality between these observations is not yet established. We studied the preventive effect of vitamin D3 (VD3) supplementation (15,000 IU/kg of food for 10 weeks) on onset of obesity in a diet-induced obesity mouse model. We showed that the VD3 supplementation limited weight gain induced by high-fat diet, which paralleled with an improvement of glucose homeostasis. The limitation of weight gain could further be explained by an increased lipid oxidation, possibly due to an up-regulation of genes involved in fatty acid oxidation and mitochondrial metabolism, leading to increased energy expenditure. Altogether, these data show that VD3 regulates energy expenditure and suggest that VD3 supplementation may represent a strategy of preventive nutrition to fight the onset of obesity and associated metabolic disorders.
authors: INRA, UMR 1260, F-13385 Marseille, France; INSERM, UMR 1062, Nutrition, Obésité et Risque Thrombotique, F-13385 Marseille, France; Aix-Marseille Université Faculté de Médecine, F-13385 Marseille, France.
authors: Julie
authors: J
authors: Marcotorchino
authors: INRA, UMR 1260, F-13385 Marseille, France; INSERM, UMR 1062, Nutrition, Obésité et Risque Thrombotique, F-13385 Marseille, France; Aix-Marseille Université Faculté de Médecine, F-13385 Marseille, France.
authors: Franck
authors: F
authors: Tourniaire
authors: INRA, UMR 1260, F-13385 Marseille, France; INSERM, UMR 1062, Nutrition, Obésité et Risque Thrombotique, F-13385 Marseille, France; Aix-Marseille Université Faculté de Médecine, F-13385 Marseille, France.
authors: Julien
authors: J
authors: Astier
authors: INRA, UMR 1260, F-13385 Marseille, France; INSERM, UMR 1062, Nutrition, Obésité et Risque Thrombotique, F-13385 Marseille, France; Aix-Marseille Université Faculté de Médecine, F-13385 Marseille, France.
authors: Esma
authors: E
authors: Karkeni
authors: INRA, UMR 1260, F-13385 Marseille, France; INSERM, UMR 1062, Nutrition, Obésité et Risque Thrombotique, F-13385 Marseille, France; Aix-Marseille Université Faculté de Médecine, F-13385 Marseille, France.
authors: Matthias
authors: M
authors: Canault
authors: INRA, UMR 1260, F-13385 Marseille, France; INSERM, UMR 1062, Nutrition, Obésité et Risque Thrombotique, F-13385 Marseille, France; Aix-Marseille Université Faculté de Médecine, F-13385 Marseille, France.
authors: Marie-Josèphe
authors: MJ
authors: Amiot
authors: Aix-Marseille Université Faculté de Médecine, F-13385 Marseille, France; CNRS, UMR 7339, Centre de Résonance Magnétique Biologique et Médicale, F-13385 Marseille, France.
authors: David
authors: D
authors: Bendahan
authors: Aix-Marseille Université Faculté de Médecine, F-13385 Marseille, France; CNRS, UMR 7339, Centre de Résonance Magnétique Biologique et Médicale, F-13385 Marseille, France.
authors: Monique
authors: M
authors: Bernard
authors: INRA, UMR 1260, F-13385 Marseille, France; INSERM, UMR 1062, Nutrition, Obésité et Risque Thrombotique, F-13385 Marseille, France; Aix-Marseille Université Faculté de Médecine, F-13385 Marseille, France.
authors: Jean-Charles
authors: JC
authors: Martin
authors: Aix-Marseille Université Faculté de Médecine, F-13385 Marseille, France; CNRS, UMR 7339, Centre de Résonance Magnétique Biologique et Médicale, F-13385 Marseille, France.
authors: Benoit
authors: B
authors: Giannesini
authors: INRA, UMR 1260, F-13385 Marseille, France; INSERM, UMR 1062, Nutrition, Obésité et Risque Thrombotique, F-13385 Marseille, France; Aix-Marseille Université Faculté de Médecine, F-13385 Marseille, France. Electronic address: jean-francois.landrier@univ-amu.fr.
authors: Jean-François
authors: JF
authors: Landrier
mesh_terms: D000818:Animals; D059305:Diet, High-Fat / Q000009:adverse effects*; D019587:Dietary Supplements; D004734:Energy Metabolism; D005947:Glucose / Q000378:metabolism; D006706:Homeostasis; D050356:Lipid Metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism; D009765:Obesity / Q000517:prevention & control*; D015854:Up-Regulation; D014807:Vitamin D / Q000008:administration & dosage* / Q000097:blood; D015430:Weight Gain
chemical_list: D014807:Vitamin D; D005947:Glucose
keywords: Adipose tissue; Adiposity; Micronutrients; Obesity; Preventive nutrition; Vitamin D