title: Enantioselective synthesis of (+)-penostatin E.
abstract: The first enantioselective total synthesis of penostatin E has been accomplished. Two highly efficient and diastereoselective reactions, a Hosomi-Sakurai allylation and an intramolecular Pauson-Khand reaction, were utilized for the construction of the basic carbon framework of the target molecule as the key steps. A late-stage introduction of the side chain and a successful base-promoted elimination reaction afforded an efficient synthetic route to (+)-penostatin E.
authors: Graduate School of Pharmaceutical Sciences, The University of Tokushima , 1-78-1 Sho-machi, Tokushima 770-8505, Japan.
authors: Kosuke
authors: K
authors: Fujioka
authors: Hiromasa
authors: H
authors: Yokoe
authors: Atsushi
authors: A
authors: Inoue
authors: Kana
authors: K
authors: Soga
authors: Masayoshi
authors: M
authors: Tsubuki
authors: Kozo
authors: K
authors: Shishido
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002942:Circular Dichroism; D007192:Indenes / Q000138:chemical synthesis* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D007192:Indenes; C000595114:penostatin E