title: Follow-up of solar lentigo depigmentation with a retinaldehyde-based cream by clinical evaluation and calibrated colour imaging.
abstract: OBJECTIVE
  To assess an objective method evaluating the effects of a retinaldehyde-based cream (RA-cream) on solar lentigines; 29 women randomly applied RA-cream on lentigines of one hand and a control cream on the other, once daily for 3 months.
  
  
  METHODS
  A specific method enabling a reliable visualisation of the lesions was proposed, using high-magnification colour-calibrated camera imaging. Assessment was performed using clinical evaluation by Physician Global Assessment score and image analysis. Luminance determination on the numeric images was performed either on the basis of 5 independent expert's consensus borders or probability map analysis via an algorithm automatically detecting the pigmented area.
  
  
  RESULTS
  Both image analysis methods showed a similar lightening of ΔL* = 2 after a 3-month treatment by RA-cream, in agreement with single-blind clinical evaluation.
  
  
  CONCLUSIONS
  High-magnification colour-calibrated camera imaging combined with probability map analysis is a fast and precise method to follow lentigo depigmentation.
authors: Skin Research Center, Pierre Fabre Laboratories, Toulouse Cedex 3, France.
authors: E
authors: E
authors: Questel
authors: E
authors: E
authors: Durbise
authors: A-L
authors: AL
authors: Bardy
authors: A-M
authors: AM
authors: Schmitt
authors: G
authors: G
authors: Josse
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003116:Color; D003124:Colorimetry / Q000379:methods; D046169:Dermoscopy / Q000379:methods; D005260:Female; D006801:Humans; D007911:Lentigo / Q000188:drug therapy* / Q000473:pathology*; D008875:Middle Aged; D010781:Photography / Q000379:methods*; D015203:Reproducibility of Results; D012172:Retinaldehyde / Q000008:administration & dosage*; D012680:Sensitivity and Specificity; D063465:Skin Cream / Q000008:administration & dosage*; D062327:Skin Lightening Preparations / Q000008:administration & dosage*; D012993:Solar Energy; D016896:Treatment Outcome
chemical_list: D062327:Skin Lightening Preparations; D012172:Retinaldehyde
keywords: chromametry; colorimetry [MeSH]; colour measurement; depigmenting agent; lentigo [MeSH]; skin ageing [MeSH]; skin imaging; skin-lightening agent; skin-lightening preparations [MeSH]