title: [Effect of statins on occurrence of infection and infection-related mortality: a meta-analysis].
abstract: OBJECTIVE
  To systematically review whether statins can reduce the risk of infection and infection-related mortality.
  
  
  METHODS
  We searched the Cochrane Library, MEDLINE, EMBASE, PubMed, Elsevier and CBM databases for randomized placebo-controlled trials of statins published by September 2013, and each trial enrolled at least 100 participants with follow-up for at least 4 weeks. Two reviewers independently assessed the quality of the included studies and extracted the relevant data for analysis using Stata 12.0 software.
  
  
  RESULTS
  Sixteen trails involving a total of 48973 patients were included in our meta-analysis. The results showed that statins significantly reduced the risk of infection (OR=0.93, 95% CI 0.89 to 0.98, P=0.004) compared to placebo but did not significantly lower infection-related mortality (OR=0.96, 95% CI 0.82 to 1.12, P=0.592).
  
  
  CONCLUSIONS
  Statins can significantly reduce the risk of infection but does not lower infection-related mortality.
authors: Institute of Respiratory Medicine, Department of Respiratory Medicine, Second Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an 710004, China. E-mail: zhxyxwgz@126.com.
authors: Guizuo
authors: G
authors: Wang
authors: Yonghong
authors: Y
authors: Zhang
authors: Xinming
authors: X
authors: Xie
authors: Dong
authors: D
authors: Han
authors: Yuanyuan
authors: Y
authors: Wu
authors: Shaojun
authors: S
authors: Li
authors: Fengjuan
authors: F
authors: Li
authors: Manxiang
authors: M
authors: Li
mesh_terms: D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D007239:Infections / Q000453:epidemiology / Q000401:mortality*; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors