title: Limonoids from the Leaves and Twigs of Walsura yunnanensis.
abstract: Nine new cedrelone limonoids, namely, walsuranolide B (1), 11β-hydroxy-23-O-methylwalsuranolide (2), yunnanolide A (3), yunnanol A (4), 11β-hydroxyisowalsuranolide (5), 11β-hydroxy-1,2-dihydroisowalsuranolide (6), 1α,11β-dihydroxy-1,2-dihydroisowalsuranolide (7), 11β-hydroxy-1α-methoxy-1,2-dihydroisowalsuranolide (8), and yunnanolide B (9), together with a new cycloartane triterpenoid, (24S*,25R*)-cycloartane-3β,24,25,26-tetrol (10), were isolated from the leaves and twigs of Walsura yunnanensis. Their structures were elucidated on the basis of spectroscopic analysis and by comparison with literature data. Compounds 3 and 5 exhibited potent cytotoxicity against five human tumor cell lines with IC50 values in the range 2.2-4.2 μM.
authors: Key Laboratory of Tropical Plant Resource and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences , Menglun, Mengla, Yunnan 666303, People's Republic of China.|University of Chinese Academy of Sciences , Beijing 100049, People's Republic of China.
authors: Kai-Long
authors: KL
authors: Ji
authors: Key Laboratory of Tropical Plant Resource and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences , Menglun, Mengla, Yunnan 666303, People's Republic of China.
authors: Ping
authors: P
authors: Zhang
authors: Key Laboratory of Tropical Plant Resource and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences , Menglun, Mengla, Yunnan 666303, People's Republic of China.
authors: Hua-Bin
authors: HB
authors: Hu
authors: Key Laboratory of Tropical Plant Resource and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences , Menglun, Mengla, Yunnan 666303, People's Republic of China.
authors: Shuai
authors: S
authors: Hua
authors: Engineering Research Center for the Development and Application of Ethnic Medicines and TCM, School of Pharmacy, Guiyang Medical College , Guiyang, Guizhou 550004, People's Republic of China.
authors: Shang-Gao
authors: SG
authors: Liao
authors: Key Laboratory of Tropical Plant Resource and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences , Menglun, Mengla, Yunnan 666303, People's Republic of China.
authors: You-Kai
authors: YK
authors: Xu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029582:Meliaceae / Q000737:chemistry*; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D013237:Stereoisomerism; D014315:Triterpenes
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D036701:Limonins; D014315:Triterpenes; C414666:cedrelone; C085352:cycloartane