title: Factors that predict thrombosis in relatives of patients with venous thromboembolism.
abstract: When counseling first-degree relatives of patients with venous thromboembolism (VTE), it is important to know whether factors other than thrombophilia influence their risk for thrombosis. We assessed the risk for VTE in 915 first-degree relatives of patients with provoked VTE, compared this with the risk in 1752 first-degree relatives of patients with unprovoked VTE, and then combined data from the 2 groups of relatives to identify predictors of thrombosis. There had been 123 VTEs in 2617 first-degree relatives (0.12 per 100 person-years). The risk for VTE in first-degree relatives was higher if the index cases had an unprovoked compared with a provoked VTE (odds ratio [OR], 2.38; 95% confidence interval [CI], 1.43-3.85), if the index case was younger (OR, 0.97 per year older; 95% CI, 0.96-0.99), and if an additional family member had VTE (OR, 2.71; 95% CI, 2.22-3.31). Among first-degree relatives of an index case with factor V Leiden or the prothrombin 20210A gene variant, the presence of these abnormalities also predicted thrombosis (OR, 4.42; 95% CI, 1.35-14.38). We conclude that thrombosis at a young age and unprovoked VTE predict VTE in first-degree relatives, and that the influence of these 2 factors is additive.
authors: Groupe d'Etude de la Thrombose de Bretagne Occidentale, Equipe d'Accueil 3878, Department of Internal Medicine and Chest Diseases, and Centre d'Investigation Clinique INSERM 0502, Groupe d'Investigation et de Recherche Clinique, Brittany University of Brest, Brest, France;
authors: Francis
authors: F
authors: Couturaud
authors: Groupe d'Etude de la Thrombose de Bretagne Occidentale, Equipe d'Accueil 3878, Department of Internal Medicine and Chest Diseases, and.
authors: Christophe
authors: C
authors: Leroyer
authors: Groupe d'Etude de la Thrombose de Bretagne Occidentale, Equipe d'Accueil 3878, Department of Internal Medicine and Chest Diseases, and.
authors: Cecile
authors: C
authors: Tromeur
authors: McMaster University and the Thrombosis and Atherosclerosis Research Institute, Hamilton, ON, Canada;
authors: Jim A
authors: JA
authors: Julian
authors: McGill University, Montreal, QC, Canada; and.
authors: Susan R
authors: SR
authors: Kahn
authors: McMaster University and the Thrombosis and Atherosclerosis Research Institute, Hamilton, ON, Canada;
authors: Jeffrey S
authors: JS
authors: Ginsberg
authors: Department of Medicine University of Ottawa, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
authors: Philip S
authors: PS
authors: Wells
authors: McMaster University and the Thrombosis and Atherosclerosis Research Institute, Hamilton, ON, Canada;
authors: James D
authors: JD
authors: Douketis
authors: Groupe d'Etude de la Thrombose de Bretagne Occidentale, Equipe d'Accueil 3878, Department of Internal Medicine and Chest Diseases, and Centre d'Investigation Clinique INSERM 0502, Groupe d'Investigation et de Recherche Clinique, Brittany University of Brest, Brest, France;
authors: Dominique
authors: D
authors: Mottier
authors: McMaster University and the Thrombosis and Atherosclerosis Research Institute, Hamilton, ON, Canada;
authors: Clive
authors: C
authors: Kearon
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005165:Factor V / Q000235:genetics; D005190:Family; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011379:Prognosis; D011516:Prothrombin / Q000235:genetics; D012307:Risk Factors; D054556:Venous Thromboembolism / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology*
chemical_list: C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin