title: Kinetic resolution of profens by enantioselective esterification catalyzed by Candida antarctica and Candida rugosa lipases.
abstract: Profens (2-arylpropionic acids) are known as one of the major nonsteroidal antiinflammatory drugs (NSAIDs) used in the treatment of inflammation associated with tissue injury. The inflammatory activity of profens is mainly due to their (S)-enantiomer, whereas they are commercially available not only as pure enantiomers, but as racemates as well. There are several methods widely used in order to obtain enantiomerically pure compounds, however, the kinetic resolution with the application of lipases as biocatalysts may have an added advantage in the production of optically pure active pharmaceutical ingredients, such as milder reaction conditions, reduced energy requirements, and production costs. The aim of this study was to compare the results described in the literature in the case of the influence of reaction medium, alcohol moiety, and reaction temperature on the catalytic activity of lipases from Candida antarctica and Candida rugosa.
authors: Department of Medicinal Chemistry, Collegium Medicum in Bydgoszcz, Faculty of Pharmacy, Nicolaus Copernicus University, Bydgoszcz, Poland.
authors: Adam
authors: A
authors: Sikora
authors: Tomasz
authors: T
authors: Siódmiak
authors: Michał Piotr
authors: MP
authors: Marszałł
mesh_terms: D002175:Candida / Q000201:enzymology*; D004951:Esterification; D007700:Kinetics; D008049:Lipase / Q000378:metabolism*; D010666:Phenylpropionates / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D010666:Phenylpropionates; D008049:Lipase
keywords: 2-arylpropionic acid; Candida antarctica lipase; Candida rugosa lipase; Novozym 435; kinetic resolution