title: Has analytical flexibility increased in imaging studies of bipolar disorder and major depression?
abstract: There has been extensive discussion of problems of reproducibility of research. Analytical flexibility may contribute to this, by increasing the likelihood that a reported finding represents a chance result. We explored whether analytical flexibility has increased over time, using human imaging studies of bipolar disorder and major depression. Our results indicate that the number of measures collected per study has increased over time for studies of bipolar disorder, but not for studies of major depression.
authors: UK Centre for Tobacco and Alcohol Studies and School of Experimental Psychology,University of Bristol,Bristol,UK.
authors: M R
authors: MR
authors: Munafò
authors: Department of Neuroimaging,Institute of Psychiatry, King's College London,London,UK.
authors: M J
authors: MJ
authors: Kempton
mesh_terms: D001714:Bipolar Disorder / Q000175:diagnosis*; D003865:Major Depressive Disorder / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging; D059906:Neuroimaging; D015203:Reproducibility of Results
keywords: Analytical flexibility; bipolar disorder; imaging; major depression