title: Inhibition of annexin A7 gene and protein induces the apotosis and decreases the invasion, migration of the hepatocarcinoma cell line.
abstract: Our previous studies have shown that annexin A7 (ANXA7) gives different expressions in the mouse hepatocarcinoma cell lines with low or high lymphatic metastatic potential in both gene and protein levels. In this study, whether by using RNA interference (RNAi) technique downregulating ANXA7 in the gene level or by using antibody against ANXA7 in the protein level, the depressed expression of ANXA7 could induce apotosis and decrease the invasion, migration capacities of the Hca-P cell, a hepatocarcinoma cell line with low lymphatic metastatic potential in vitro. The results indicate that ANXA7 is an important factor in tumors with the lymphatic metastasis.
authors: Department of Pathology, Dalian Medical University, Key Laboratory for Tumor Metastasis of Liaoning Province, Dalian, Liaoning Province, PR China. Electronic address: huangyh_1020@163.com.
authors: Yuhong
authors: Y
authors: Huang
authors: Department of Pathology, Dalian Medical University, Key Laboratory for Tumor Metastasis of Liaoning Province, Dalian, Liaoning Province, PR China.
authors: Qing
authors: Q
authors: Wang
authors: Department of Pathology, Dalian Medical University, Key Laboratory for Tumor Metastasis of Liaoning Province, Dalian, Liaoning Province, PR China.
authors: Yue
authors: Y
authors: Du
authors: Department of Pathology, Dalian Medical University, Key Laboratory for Tumor Metastasis of Liaoning Province, Dalian, Liaoning Province, PR China.
authors: Lulu
authors: L
authors: Bai
authors: Dalian Maternity Hospital, Dalian, Liaoning Province, PR China.
authors: Fen
authors: F
authors: Jin
authors: Department of Pathology, Dalian Medical University, Key Laboratory for Tumor Metastasis of Liaoning Province, Dalian, Liaoning Province, PR China.
authors: Jun
authors: J
authors: Zhang
authors: Department of Pathology, Dalian Medical University, Key Laboratory for Tumor Metastasis of Liaoning Province, Dalian, Liaoning Province, PR China.
authors: Shujun
authors: S
authors: Fan
authors: Department of Pathology, Dalian Medical University, Key Laboratory for Tumor Metastasis of Liaoning Province, Dalian, Liaoning Province, PR China.
authors: Huaxin
authors: H
authors: Wang
authors: Department of Pathology, Dalian Medical University, Key Laboratory for Tumor Metastasis of Liaoning Province, Dalian, Liaoning Province, PR China.
authors: Lin
authors: L
authors: Song
authors: Department of Pathology, Dalian Medical University, Key Laboratory for Tumor Metastasis of Liaoning Province, Dalian, Liaoning Province, PR China.
authors: Yue
authors: Y
authors: Gao
authors: Department of Pathology, Dalian Medical University, Key Laboratory for Tumor Metastasis of Liaoning Province, Dalian, Liaoning Province, PR China.
authors: Xianyan
authors: X
authors: Wang
authors: Department of Pathology, Dalian Medical University, Key Laboratory for Tumor Metastasis of Liaoning Province, Dalian, Liaoning Province, PR China. Electronic address: jwtang@sina.cn.
authors: Jianwu
authors: J
authors: Tang
mesh_terms: D000818:Animals; D017310:Annexin A7 / Q000235:genetics*; D017209:Apoptosis / Q000235:genetics*; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics*; D015536:Down-Regulation / Q000235:genetics; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology; D008207:Lymphatic Metastasis / Q000235:genetics* / Q000473:pathology; D051379:Mice; D034622:RNA Interference
chemical_list: D017310:Annexin A7; C480504:Anxa7 protein, mouse
keywords: Annexin A7 (ANXA7); Apoptosis; Lymphatic metastasis