title: Endothelin-1 levels and biomarkers of oxidative stress in glaucoma patients.
abstract: To investigate the levels of endothelin-1 (ET-1), homocysteine (Hcy), vitamins A, E, B12 and folic acid in plasma of patients with different types of glaucoma: primary open-angle glaucoma (POAG) and normotensive glaucoma (NTG). Patients were classified into 3 groups: group POAG comprised 48 patients, group NTG comprised 15 patients, and control group that comprised 75 healthy subjects. ET-1 levels were measured by ELISA, Vitamins A and E by HPLC, and Vitamin B12, homocysteine, and folic acid levels were determined by chemiluminescent immunoassay. The ET-1 and Hcy levels were significantly higher (p = 0.002) in the POAG group compared to NTG and control group. Vitamin E levels were significantly lower (p = 0.001) in the NTG group compared to POAG and control group. The increase of Hcy and ET-1 in POAG patients is related to vascular endothelial dysfunction. Thus results may play a key role in the development of this disease. Lower levels of Vitamin E in the NTG group suggest that oxidative process plays an early role in the development of this type of glaucoma.
authors: Clinical Laboratory, General University Hospital, Elche, Spain, sagona@terra.com.
authors: N
authors: N
authors: López-Riquelme
authors: C
authors: C
authors: Villalba
authors: C
authors: C
authors: Tormo
authors: A
authors: A
authors: Belmonte
authors: C
authors: C
authors: Fernandez
authors: G
authors: G
authors: Torralba
authors: F
authors: F
authors: Hernández
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000502:physiology; D016022:Case-Control Studies; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D005492:Folic Acid / Q000097:blood; D005901:Glaucoma / Q000097:blood*; D006710:Homocysteine / Q000097:blood; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D014815:Vitamins / Q000097:blood
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D019332:Endothelin-1; D014815:Vitamins; D006710:Homocysteine; D005492:Folic Acid