title: Correlations among antiangiogenic factors and trace elements in hypertensive disorders of pregnancy.
abstract: Although a number of studies have measured circulating levels of some trace elements in preeclampsia (PE) and compared to healthy pregnant (HP), there is no consensus yet about the deficiency of some metals and development of hypertensive disorders in pregnancy. The aim of this study was to compare plasmatic levels of Zn, Mn, Co, Cu, Se and Sr among non-pregnant (NP), healthy pregnant (HP), gestational hypertensive (GH) and preeclamptic (PE) women and to correlate these levels with plasma soluble endoglin (sENG) and soluble fms-like tyrosine kinase-1 (sFLT-1), two important antiangiogenic proteins related to PE. A total of 184 women were enrolled in this study (NP=35, GH=51, PE=37 and HP=61). Trace element analyses were carried out with an inductively coupled plasma mass spectrometer (ICPMS). sENG and sFLT-1 plasma concentrations were measured by commercial ELISA kits. The most interesting result is that Sr is higher in PE (63%, P<0.001) compared to HP and their levels are positively correlated with sENG in all three groups of pregnant women. Moreover, we found a negative correlation between Zn and sENG in HP (r=-0.43, P=0.003). Regarding other elements, we found similar levels among pregnant groups. In conclusion, this study showed that Sr may has a role in physiopathology of PE.
authors: Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of University of São Paulo - USP, Ribeirao Preto, SP, Brazil.
authors: Vania B
authors: VB
authors: Rezende
authors: Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of University of São Paulo - USP, Ribeirao Preto, SP, Brazil.
authors: Fernando
authors: F
authors: Barbosa
authors: Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, SP, Brazil.
authors: Ana C
authors: AC
authors: Palei
authors: Department of Gynecology and Obstetrics, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil.
authors: Ricardo C
authors: RC
authors: Cavalli
authors: Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil.
authors: Jose E
authors: JE
authors: Tanus-Santos
authors: Department of Pharmacology, Institute of Biosciences, Universidade Estadual Paulista (UNESP), Botucatu, São Paulo, Brazil; Center for Toxicological Assistance - CEATOX, Institute of Biosciences, Universidade Estadual Paulista (UNESP), Botucatu, SP, Brazil. Electronic address: valeria.sandrim@ibb.unesp.br.
authors: Valeria C
authors: VC
authors: Sandrim
mesh_terms: D000328:Adult; D020533:Angiogenesis Inhibitors / Q000097:blood*; D015703:Antigens, CD / Q000097:blood*; D001938:Brazil; D000071063:Endoglin; D005260:Female; D005865:Gestational Age; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000097:blood*; D011225:Pre-Eclampsia; D011247:Pregnancy; D011956:Receptors, Cell Surface / Q000097:blood*; D012995:Solubility; D013324:Strontium / Q000097:blood; D014131:Trace Elements / Q000097:blood*; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood*; D015032:Zinc / Q000097:blood
chemical_list: D020533:Angiogenesis Inhibitors; D015703:Antigens, CD; C064206:ENG protein, human; D000071063:Endoglin; D011956:Receptors, Cell Surface; D014131:Trace Elements; C501162:FLT1 protein, human; D040281:Vascular Endothelial Growth Factor Receptor-1; D015032:Zinc; D013324:Strontium
keywords: Preeclampsia; Sr; Trace elements; Zn; sFLT-1