title: Genetic association between a 'standing' variant of NOD2 and bipolar disorder.
abstract: Bipolar disorders (BD) are chronic, multisystem and multifactorial disorders with significant lifetime morbidity, mortality and socio-economic burden. Understanding the underlying genetic and disease triggering environmental factors should improve diagnosis, prognosis, prevention and therapeutic management of the disease. Since intestinal innate dysimmunity seems to play a significant role in the etiopathogeny of BD, we explored in a sample of French Caucasian BD patients, the genetic polymorphisms of NOD2 (nucleotide-binding oligomerization domain containing 2) gene, a key player in such immunity. We found a Caucasian-specific 'standing' variation to be associated with BD. The significance of this finding is discussed in the context of Crohn's disease as well as the complex function of NOD2 in innate immunity.
authors: INSERM, U1160, Hôpital Saint Louis, Paris F75010, France; Fondation FondaMental, Créteil F94000, France.
authors: José
authors: J
authors: Oliveira
authors: INSERM, U955, Psychiatrie Génétique, Créteil F94000, France; Université Paris-Est, Faculté de Médecine, Créteil F94000, France; AP-HP, DHU PePSY, Pôle de Psychiatrie, Hôpitaux Universitaires Henri Mondor, Créteil F94000, France; Fondation FondaMental, Créteil F94000, France.
authors: Nora
authors: N
authors: Hamdani
authors: INSERM, U955, Psychiatrie Génétique, Créteil F94000, France; Université Paris-Est, Faculté de Médecine, Créteil F94000, France; AP-HP, DHU PePSY, Pôle de Psychiatrie, Hôpitaux Universitaires Henri Mondor, Créteil F94000, France; Fondation FondaMental, Créteil F94000, France.
authors: Bruno
authors: B
authors: Etain
authors: INSERM, U1160, Hôpital Saint Louis, Paris F75010, France; Fondation FondaMental, Créteil F94000, France.
authors: Meriem
authors: M
authors: Bennabi
authors: INSERM, U1160, Hôpital Saint Louis, Paris F75010, France.
authors: Wahid
authors: W
authors: Boukouaci
authors: INSERM, U1160, Hôpital Saint Louis, Paris F75010, France; Laboratoire Jean Dausset, LabEx Transplantex, Hôpital Saint Louis, Paris F75010, France.
authors: Kahina
authors: K
authors: Amokrane
authors: Laboratoire Jean Dausset, LabEx Transplantex, Hôpital Saint Louis, Paris F75010, France.
authors: Catherine
authors: C
authors: Fortier
authors: Laboratoire Jean Dausset, LabEx Transplantex, Hôpital Saint Louis, Paris F75010, France.
authors: François
authors: F
authors: Marzais
authors: Laboratoire Jean Dausset, LabEx Transplantex, Hôpital Saint Louis, Paris F75010, France.
authors: Djaouida
authors: D
authors: Bengoufa
authors: INSERM, U955, Psychiatrie Génétique, Créteil F94000, France; Université Paris-Est, Faculté de Médecine, Créteil F94000, France; AP-HP, DHU PePSY, Pôle de Psychiatrie, Hôpitaux Universitaires Henri Mondor, Créteil F94000, France; Fondation FondaMental, Créteil F94000, France.
authors: Frank
authors: F
authors: Bellivier
authors: INSERM, U955, Psychiatrie Génétique, Créteil F94000, France; Université Paris-Est, Faculté de Médecine, Créteil F94000, France; AP-HP, DHU PePSY, Pôle de Psychiatrie, Hôpitaux Universitaires Henri Mondor, Créteil F94000, France; Fondation FondaMental, Créteil F94000, France.
authors: Chantal
authors: C
authors: Henry
authors: Service de Psychiatrie et Psychologie Clinique, CHU de Nancy, Hôpitaux de Brabois, Vandoeuvre Les Nancy F54500, France; Fondation FondaMental, Créteil F94000, France.
authors: Jean-Pierre
authors: JP
authors: Kahn
authors: INSERM, U1160, Hôpital Saint Louis, Paris F75010, France; Laboratoire Jean Dausset, LabEx Transplantex, Hôpital Saint Louis, Paris F75010, France; Fondation FondaMental, Créteil F94000, France; Université Paris Diderot, Sorbonne Paris-Cité, Paris F75013, France.
authors: Dominique
authors: D
authors: Charron
authors: INSERM, U1160, Hôpital Saint Louis, Paris F75010, France.
authors: Rajagopal
authors: R
authors: Krishnamoorthy
authors: INSERM, U955, Psychiatrie Génétique, Créteil F94000, France; Université Paris-Est, Faculté de Médecine, Créteil F94000, France; AP-HP, DHU PePSY, Pôle de Psychiatrie, Hôpitaux Universitaires Henri Mondor, Créteil F94000, France; Fondation FondaMental, Créteil F94000, France.
authors: Marion
authors: M
authors: Leboyer
authors: INSERM, U1160, Hôpital Saint Louis, Paris F75010, France; Laboratoire Jean Dausset, LabEx Transplantex, Hôpital Saint Louis, Paris F75010, France; Fondation FondaMental, Créteil F94000, France; Université Paris Diderot, Sorbonne Paris-Cité, Paris F75013, France. Electronic address: tamouza.ryad@gmail.com.
authors: Ryad
authors: R
authors: Tamouza
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001714:Bipolar Disorder / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D005091:Exons; D005260:Female; D005602:France / Q000453:epidemiology; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D053473:Nod2 Signaling Adaptor Protein / Q000235:genetics*; D011110:Polymorphism, Genetic; D044465:White People / Q000235:genetics*; D055815:Young Adult
chemical_list: C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein
keywords: Bipolar disorder; Immunogenetics; Inflammation; Innate immunity; NOD2