title: Applicability of crystalline cellulose membrane in the treatment of skin wounds induced in Wistar rats.
abstract: OBJECTIVE
  To evaluate the healing of skin wounds induced experimentally in rats using a crystalline cellulose membrane (Veloderm®).
  
  
  METHODS
  Thirty-two rats were divided into two groups: control group (CG) wounds treated with a solution of 0.9% sodium chloride and Veloderm® group (VG) wounds treated with a crystalline cellulose membrane. The rats were evaluated at different times over twenty-six days.
  
  
  RESULTS
  Weight loss was observed in the animals from both groups in the early stages, with greater weight in the VG animals at the end. Times of predominant hypothermia, pink color of the wound in both groups over all time points, increased granulation tissue in the CG animals, the presence of slight oozing from the wound and feature in the VG animals, more serous exudation of the bloody feature, greater wound contraction and pain in the CG animals and an absence of pain and earlier complete wound healing in the VG rats were also observed.
  
  
  CONCLUSIONS
  The crystalline cellulose membrane is effective in the treatment of wounds in rats, easy to use, protects and maintains the humidity of the wound, decreases pain, eases the visualization and control of the evolution of the lesion.
authors: Oeste Paulista University, Presidente Prudente, SP, Brazil.
authors: Milena Colonhese
authors: MC
authors: Camargo
authors: Department of Medical Clinic, UNOESTE, Presidente Prudente, SP, Brazil.
authors: Rosa Maria Barilli
authors: RM
authors: Nogueira
authors: Department of Pathology, UNOESTE, Presidente Prudente, SP, Brazil.
authors: Osimar de Carvalho
authors: Ode C
authors: Sanches
authors: Scholl of Veterinary Medicine, UNOESTE, Presidente Prudente, SP, Brazil.
authors: Maria da Graça
authors: Mda G
authors: Saab
authors: Scholl of Veterinary Medicine, UNOESTE, Presidente Prudente, SP, Brazil.
authors: Aline
authors: A
authors: Batista
authors: Scholl of Nursing, UNOESTE, Presidente Prudente, SP, Brazil.
authors: Diane
authors: D
authors: Vasconcelos
authors: Scholl of Nursing, UNOESTE, Presidente Prudente, SP, Brazil.
authors: Letícia Yuri
authors: LY
authors: Luvisotto
authors: Scholl of Nursing, UNOESTE, Presidente Prudente, SP, Brazil.
authors: Marco Aurélio Aparecido
authors: MA
authors: Lúcio
mesh_terms: D000818:Animals; D002482:Cellulose / Q000627:therapeutic use; D005122:Exudates and Transudates; D006097:Granulation Tissue; D008297:Male; D011134:Polysaccharides / Q000627:therapeutic use*; D017208:Rats, Wistar; D015203:Reproducibility of Results; D012867:Skin / Q000187:drug effects* / Q000293:injuries*; D012965:Sodium Chloride / Q000627:therapeutic use; D013997:Time Factors; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
chemical_list: D011134:Polysaccharides; D012965:Sodium Chloride; C007916:hemicellulose; D002482:Cellulose