title: Management of calcium channel blocker overdoses.
abstract: Calcium channel blockers (CCBs) are some of the most commonly used medications in clinical practice to treat hypertension, angina, cardiac arrhythmias, and some cases of heart failure. Recent data show that CCBs are the most common of the cardiovascular medications noted in intentional or unintentional overdoses.(1) Novel treatment approaches in the form of glucagon, high-dose insulin therapy, and intravenous lipid emulsion therapies have been tried and have been successful. However, the evidence for these are limited to case reports and case series. We take this opportunity to review the various treatment options in the management of CCB overdoses with a special focus on high-dose insulin therapy as the emerging choice for initial therapy in severe overdoses.
authors: Division of Inpatient Medicine, University of Arizona, Tucson, Arizona.
authors: Sundeep
authors: S
authors: Shenoy
authors: Shilpa
authors: S
authors: Lankala
authors: Sasikanth
authors: S
authors: Adigopula
mesh_terms: D058109:Airway Management / Q000379:methods; D002121:Calcium Channel Blockers / Q000506:poisoning*; D017610:Calcium Compounds / Q000008:administration & dosage; D002395:Catecholamines / Q000008:administration & dosage; D062787:Drug Overdose / Q000628:therapy*; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage; D005934:Glucagon / Q000008:administration & dosage; D006801:Humans; D006946:Hyperinsulinism / Q000628:therapy; D017693:Sodium Bicarbonate / Q000008:administration & dosage
chemical_list: D002121:Calcium Channel Blockers; D017610:Calcium Compounds; D002395:Catecholamines; D005217:Fat Emulsions, Intravenous; D017693:Sodium Bicarbonate; D005934:Glucagon