title: Lipid profile and non-cholesterol sterols in obese women's serum after supplementing with plant stanol ester.
abstract: BACKGROUND
  The aim of this study was to assess the influence of increased plant stanol ester intake on lipid profile and serum ratio of non-cholesterol sterols to cholesterol in obese women (50 years of age) with dyslipidemia.
  
  
  METHODS
  90 females were assigned into 2 treatment groups: For a period of 4 weeks, group 1 was receiving a yoghurt, enriched with 2 g of plant stanol ester (PS group), and group 2 was receiving a yoghurt drink without extra stanols. Anthropometric measurements included body height and weight. Lipid profile was determined by commercially available enzymatic methods. Serum non-cholesterol sterols and stanols concentrations were quantitated by gas chromatography. The study was single-blind and placebo-controlled.
  
  
  RESULTS
  The yoghurt drink enriched with plant stanol ester significantly reduced serum total cholesterol, LDL cholesterol, and non-HDL cholesterol levels (p < 0.05). No changes were observed in HDL cholesterol and triacylglycerol levels. The highest drop of LDL cholesterol was noted in the upper quartile of total cholesterol concentrations. In the PS group the statistically significant (p < 0.0001) changes were also observed in serum ratios of non-cholesterol sterols to cholesterol: campesterol, sitosterol, sitostanol, and avenasterol.
  
  
  CONCLUSIONS
  Plant stanol esters influence the concentration of total cholesterol, particularly LDL cholesterol. This effect seems to be related to the reduced dietary cholesterol absorption.
authors: Department of Bromatology and Human Nutrition, Poznan University of Medical Sciences, Poznan, Poland.
authors: Marta
authors: M
authors: Stelmach-Mardas
authors: Jarosław
authors: J
authors: Walkowiak
authors: Paweł
authors: P
authors: Zagrodzki
authors: Bogna
authors: B
authors: Grygiel-Górniak
authors: Juliusz
authors: J
authors: Przysławski
mesh_terms: D000284:Administration, Oral; D000924:Anticholesteremic Agents / Q000008:administration & dosage; D050171:Dyslipidemias / Q000150:complications / Q000628:therapy*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D012855:Sitosterols / Q000008:administration & dosage*; D013261:Sterols / Q000097:blood*; D016896:Treatment Outcome
chemical_list: D000924:Anticholesteremic Agents; D008055:Lipids; D012855:Sitosterols; D013261:Sterols; C407042:plant stanol ester