title: Protein assembly mediated by sulfonatocalix[4]arene.
abstract: A crystal structure of lysozyme in complex with p-sulfonato-calix[4]arene (sclx4) reveals a linear assembly of protein tetramers glued together by protein-calixarene interactions. One interaction involves encapsulation of the highly exposed C-terminal Arg128. The other involves an intricate protein-bound complex of sclx4, Mg(2+) and a fragment of polyethylene glycol.
authors: School of Chemistry, National University of Ireland Galway, University Road, Galway, Ireland. peter.crowley@nuigalway.ie.
authors: Róise E
authors: RE
authors: McGovern
authors: Andrew A
authors: AA
authors: McCarthy
authors: Peter B
authors: PB
authors: Crowley
mesh_terms: D001665:Binding Sites; D047250:Calixarenes / Q000737:chemistry* / Q000378:metabolism; D018360:Crystallography, X-Ray; D056004:Molecular Dynamics Simulation; D009113:Muramidase / Q000737:chemistry* / Q000378:metabolism; D010636:Phenols / Q000737:chemistry* / Q000378:metabolism; D011092:Polyethylene Glycols / Q000737:chemistry / Q000378:metabolism; D011485:Protein Binding; D020836:Protein Structure, Quaternary; D013451:Sulfonic Acids / Q000737:chemistry*
chemical_list: D010636:Phenols; D013451:Sulfonic Acids; C121325:calix(4)arene; D047250:Calixarenes; D011092:Polyethylene Glycols; D009113:Muramidase