title: Central aortic pressure and pulsatility index in acute ischemic stroke.
abstract: OBJECTIVE
  We investigated the relationship between transcranial Doppler (TCD) pulsatility index (PI) and central aortic pressure by measurement of the aortic augmentation index (AIx).
  
  
  METHODS
  We enrolled 148 consecutive patients with a diagnosis of acute ischemic stroke. Patients were eligible for the study if they experienced their first ischemic stroke within the preceding 7 days and were 45 years of age or older. At Day 7 (±2) after stroke onset, TCD studies were performed and AIx was measured by applanation tonometry on the same days.
  
  
  RESULTS
  The mean age was 66.3 (47-90) years and 37.8% were women. The mean middle cerebral artery (MCA) PI was significantly related with age (r =.361), hypertension (r = .184), peripheral systolic blood pressure (SBP; r = .211), peripheral pulse pressure (PP; r = .396), aortic SBP (r = .184), aortic DBP (r = -.181), and aortic PP (r = .371). The basilar artery (BA) PI was significantly related with age (r = .311), peripheral DBP (r = -.267), peripheral PP (r = .358), aortic DBP (r = -.266), and aortic PP (r = .347).
  
  
  CONCLUSIONS
  TCD PI was significantly related with central aortic pressure, especially PP. The PI in the MCA and BA is closely associated with the pulsatile component of BP in the systemic circulation.
authors: Department of Neurology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.
authors: Jeong Yeon
authors: JY
authors: Kim
authors: Cheryl D
authors: CD
authors: Bushnell
authors: Joong Hyun
authors: JH
authors: Park
authors: Seung Min
authors: SM
authors: Han
authors: Jin Hee
authors: JH
authors: Im
authors: Sang Won
authors: SW
authors: Han
authors: Jong Sam
authors: JS
authors: Baik
authors: Jae Hyeon
authors: JH
authors: Park
mesh_terms: D000368:Aged; D062186:Arterial Pressure; D001794:Blood Pressure; D002536:Cerebral Arteries / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011673:Pulsatile Flow; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D020521:Stroke / Q000000981:diagnostic imaging / Q000503:physiopathology*; D017585:Ultrasonography, Doppler, Transcranial / Q000379:methods*; D014655:Vascular Resistance
keywords: Arterial stiffness; central aortic pressure; ischemic stroke; pulsatility index