title: Effects of synbiotic food consumption on glycemic status and serum hs-CRP in pregnant women: a randomized controlled clinical trial.
abstract: OBJECTIVE
  The aim of this study was to determine the effects of synbiotic food consumption on glycemic status and serum high sensitivity C-reactive protein (hs-CRP) levels of Iranian pregnant women.
  
  
  METHODS
  This randomized placebo-controlled clinical trial was performed among 52 pregnant women, primigravida, aged 18-35 year old, in their third trimester. After a 2-wk run-in period, subjects were randomly assigned to consume either a synbiotic (n=26) or control food (n=26) for 9 weeks. The synbiotic food consisted of a probiotic Lactobacillus sporogenes (1×107 CFU), 0.04 g inulin as prebiotic with 0.38 g isomalt, 0.36 g sorbitol and 0.05 g stevia as sweetener per 1 g. Control food (the same substance without probiotic bacteria and inulin) was packed in identical 9-gram packages. Patients were asked to consume the synbiotic and control foods two times a day. Fasting blood samples were taken at baseline and after a 9-wk intervention for quantification of related factors.
  
  
  RESULTS
  Consumption of a synbiotic food did not show any significant change regarding the impact of insulin actions in the synbiotic group; nonetheless, compared to the control food, it resulted in a significant decrease in serum insulin levels (-0.26 vs. 6.34 µIU/mL, P=0.014) and HOMA-IR (-0.13 vs. 1.13, P=0.033), a significant difference in HOMA-B (5.30 vs. 34.22, P=0.040) and a significant rise in QUICKI score (0.002 vs. -0.02, P=0.022).
  
  
  CONCLUSIONS
  Consumption of a synbiotic food for 9 weeks by pregnant women had beneficial effects on insulin actions compared to the control food, but did not affect FPG and serum hs-CRP concentrations.
authors: Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R. Iran.
authors: Mohsen
authors: M
authors: Taghizadeh
authors: Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R. Iran.
authors: Zatolla
authors: Z
authors: Asemi
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood*; D001786:Blood Glucose / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism*; D004032:Diet; D004187:Disaccharides / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007444:Inulin / Q000008:administration & dosage; D007492:Iran; D007778:Lactobacillus / Q000145:classification / Q000502:physiology; D009752:Nutritional Status; D056692:Prebiotics; D011247:Pregnancy; D011263:Pregnancy Trimester, Third / Q000097:blood; D039401:Prenatal Nutritional Physiological Phenomena; D019936:Probiotics / Q000008:administration & dosage*; D013012:Sorbitol / Q000008:administration & dosage; D036625:Stevia; D013402:Sugar Alcohols / Q000008:administration & dosage; D013549:Sweetening Agents / Q000008:administration & dosage; D058616:Synbiotics; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D004187:Disaccharides; D007328:Insulin; D056692:Prebiotics; D013402:Sugar Alcohols; D013549:Sweetening Agents; D013012:Sorbitol; C016640:Palatinit; D007444:Inulin; D002097:C-Reactive Protein