title: Preterm birth in the first pregnancy and risk of neonatal death in the second pregnancy: a propensity score-weighted matching approach.
abstract: The study purpose was to assess the relationship between various grades of preterm birth (moderate preterm: 33-36 weeks; severe preterm: 27-32 weeks; extreme preterm: ≤ 26 weeks) in the first pregnancy and neonatal mortality (death within 28 days of birth; early: 0-7 days; late: 8-28 days) in the second pregnancy. Using the Missouri maternally-linked dataset (1989-2005), a population-based, retrospective cohort analysis with propensity score-weighted matching was conducted on mothers with two consecutive singleton live births (n = 310,653 women). Women with a prior preterm birth were more likely to subsequently experience neonatal death. The odds increased in a dose-dependent pattern with ascending severity of the preterm event in the first pregnancy (moderate preterm: AOR = 1.32; 95% CI: 1.10-1.60; severe preterm: AOR = 2.62; 95% CI: 2.01-3.41; extreme preterm: AOR = 5.84; 95% CI: 4.28-7.97; p value for trend < 0.001). However, the pathway for the relationship between prior preterm birth and subsequent neonatal mortality may be the recurrence of preterm birth.
authors: Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, College of Medicine.
authors: V E
authors: VE
authors: Whiteman
authors: E M
authors: EM
authors: August
authors: M
authors: M
authors: Mogos
authors: E
authors: E
authors: Naik
authors: M
authors: M
authors: Garba
authors: E
authors: E
authors: Sanchez
authors: H E
authors: HE
authors: Weldeselasse
authors: H M
authors: HM
authors: Salihu
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008923:Missouri / Q000453:epidemiology; D066087:Perinatal Death; D011247:Pregnancy; D047928:Premature Birth / Q000453:epidemiology*; D057216:Propensity Score; D012189:Retrospective Studies
keywords: Birth outcomes; neonatal mortality; pregnancy; preterm birth