title: Dose-response-relationship between number of laser burns and IOP reduction in cyclophotocoagulation: an animal study.
abstract: OBJECTIVE
  The relationship between number of laser burns of cyclophotocoagulation (CPC) and intraocular pressure (IOP) reduction is unknown. This animal model was established to reveal a possible dose-response-relationship between the number of applied laser burns and the IOP lowering effect.
  
  
  METHODS
  30 chinchilla bastard rabbits were divided into 5 groups and treated with either 1, 5, 10, 20, or 30 CPC burns, respectively. IOP was followed up for 1 week. IOP reduction of a single 30-burn treatment was compared with a fractionated treatment (three sessions; one week in between; 10 burns/session).
  
  
  RESULTS
  IOP reduction increases nonlinearly with the number of CPC burns (max. -6.1 ± 1.4 mmHg). Fractionated treatment shows similar IOP reduction with less complications and more constant results compared to single session treatment.
  
  
  CONCLUSIONS
  The study reveals a complex relationship between IOP reduction and the number of CPC burns. Fractionated CPC gives comparable IOP reduction at a higher degree of safety.
authors: Department of Ophthalmology, University Medical-Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
authors: Lars
authors: 0000-0001-8838-2194
authors: L
authors: Wagenfeld
authors: Department of Ophthalmology, University Medical-Center Hamburg-Eppendorf, 20246 Hamburg, Germany ; Department of Ophthalmology, RWTH Aachen University, 52074 Aachen, Germany.
authors: Hendrik
authors: 0000-0003-3021-5769
authors: H
authors: Schwarzer
authors: Department of Ophthalmology, RWTH Aachen University, 52074 Aachen, Germany.
authors: Gernot
authors: 0000-0002-0660-8645
authors: G
authors: Roessler
authors: Department of Ophthalmology, University Medical-Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
authors: Maren
authors: M
authors: Klemm
authors: Department of Ophthalmology, University Medical-Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
authors: Christos
authors: 0000-0003-3389-4840
authors: C
authors: Skevas
authors: Department of Ophthalmology, University Medical-Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
authors: Gisbert
authors: G
authors: Richard
authors: Department of Ophthalmology, University Medical-Center Hamburg-Eppendorf, 20246 Hamburg, Germany ; Global Clinical Development, Bayer HealthCare AG, 13353 Berlin, Germany.
authors: Oliver
authors: O
authors: Zeitz
mesh_terms: D000818:Animals; D002056:Burns / Q000503:physiopathology*; D002682:Chinchilla; D002924:Ciliary Body / Q000502:physiology; D005901:Glaucoma / Q000628:therapy*; D007429:Intraocular Pressure; D007834:Lasers; D008027:Light; D008028:Light Coagulation / Q000379:methods*; D023421:Models, Animal; D011817:Rabbits; D014945:Wound Healing