title: Meta-analyses of 10 polymorphisms associated with the risk of schizophrenia.
abstract: Schizophrenia (SCZ) is a severe complex psychiatric disorder that generates problems for the associated family and society and causes disability with regards to work for patients. The aim of the present study was to assess the contribution of 10 genetic polymorphisms to SCZ susceptibility. Meta-analyses were conducted using the data without a limitation for time or language. A total of 27 studies with 7 genes and 10 polymorphisms were selected for the meta-analyses. Two polymorphisms were found to be significantly associated with SCZ.SNAP25rs3746544 was shown to increase the SCZ risk by 18% [P=0.01; odds ratio (OR), 1.18; 95% confidence interval (CI), 1.05-1.34] andGRIK3rs6691840 was found to increase the risk by 30% (P=0.008; OR, 1.30; 95% CI, 1.07-1.58). Significant results were found under the dominant (P=0.001; OR, 1.36; 95% CI, 1.13-1.65) and additive (P=0.02; OR, 1.45; 95% CI, 1.06-1.98) model for theSNAP25rs3746544 polymorphism and under the additive model for theGRIK3rs6691840 polymorphism (P=0.03; OR, 1.73; 95% CI, 1.04-2.85). There were no significant results observed for the other eight polymorphisms, which wereCCKARrs1800857,CHRNA7rs904952,CHRNA7rs6494223,CHRNA7rs2337506,DBHIns>Del,FEZ1rs559668,FEZ1rs597570 andGCLMrs2301022. In conclusion, the present meta-analyses indicated that theSNAP25rs3746544 andGRIK3rs6691840 polymorphisms were risk factors of SCZ, which may provide valuable information for the clinical diagnosis of SCZ.
authors: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors: Dongjun
authors: D
authors: Dai
authors: Department of Neurology, The 148 Central Hospital of People's Liberation Army, Zibo, Shandong 255300, P.R. China.
authors: Yunliang
authors: Y
authors: Wang
authors: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors: Jiaojiao
authors: J
authors: Yuan
authors: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors: Xingyu
authors: X
authors: Zhou
authors: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors: Danjie
authors: D
authors: Jiang
authors: Department of Neurology, The 148 Central Hospital of People's Liberation Army, Zibo, Shandong 255300, P.R. China.
authors: Jinfeng
authors: J
authors: Li
authors: Department of Neurology, The 148 Central Hospital of People's Liberation Army, Zibo, Shandong 255300, P.R. China.
authors: Yuzheng
authors: Y
authors: Zhang
authors: Department of Neurology, The 148 Central Hospital of People's Liberation Army, Zibo, Shandong 255300, P.R. China.
authors: Honglei
authors: H
authors: Yin
authors: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors: Shiwei
authors: S
authors: Duan
keywords: GRIK3 rs6691840; SNAP25 rs3746544; meta-analysis; polymorphism; schizophrenia