title: Discovering cancer immunotherapy targets in vivo.
abstract: A key challenge facing the cancer immunology field is the discovery of the most suitable targets for therapeutic intervention. We recently reported a novel RNA-interference (RNAi)-based approach for systematic discovery of such targets in the tumor microenvironment in vivo utilizing pooled shRNA libraries as a screening tool. Here, we discuss applying this unbiased method to develop innovative cancer therapeutics.
authors: Dana-Farber Cancer Institute; Boston, MA USA.
authors: Penghui
authors: P
authors: Zhou
authors: Dana-Farber Cancer Institute; Boston, MA USA ; Program in Immunology; Harvard Medical School; Boston, MA USA.
authors: Kai W
authors: KW
authors: Wucherpfennig
keywords: RNAi screen; T cell; cancer; therapeutic targets; tumor microenvironment