title: Use of (99m)Tc-anti-TNF-α scintigraphy in a patient with non-radiographic axial spondyloarthritis.
abstract: The aim of this study was to describe the use of (99m)Tc-anti-TNF-α scintigraphy for detecting inflammation of the sacroiliac joints in a patient with non-radiographic axial spondyloarthritis. A 47-year-old female patient, non-smoker and non-drinker, complained of a low back pain inflammation, which began 4 years before her condition have exacerbated to morning stiffness and anterior uveitis in the last 6 months. Initially diagnosed as mechanical low back pain, she irregularly took non-steroidal anti-inflammatory drugs and corticosteroids, without significant long-lasting results. Radiographic findings were negative. There was increased uptake of (99m)Tc-anti-TNF-α in an area corresponding to the topography of ileum and sacroiliac right joint upon (99m)Tc-anti-TNF-α scintigraphy. Magnetic resonance imaging (MRI), the most used image diagnosis tool, showed minimum impregnation of gadolinium in the right sacroiliac joint and at the iliac face of the inferior third of the right sacroiliac joint. We suggest that (99m)Tc-anti-TNF-α can facilitate early diagnosis of patients with non-radiographic axial spondyloarthritis. More studies are now ongoing.
authors: Instituto Nacional de Traumatologia e Ortopedia (Into), Ministério da Saúde, Rio de Janeiro (RJ), Brazil.
authors: Dângelo José
authors: DJ
authors: de Andrade Alexandre
authors: Sergio Augusto Lopes
authors: SA
authors: de Souza
authors: Clarissa Canella
authors: CC
authors: Moraes do Carmo
authors: Bruno
authors: B
authors: Schau
authors: Lea Mirian Barbosa
authors: LM
authors: da Fonseca
authors: Luis
authors: L
authors: Roimicher
authors: Bianca
authors: B
authors: Gutfilen
mesh_terms: D000068879:Adalimumab; D061067:Antibodies, Monoclonal, Humanized; D003287:Contrast Media; D003937:Diagnosis, Differential; D005260:Female; D005682:Gadolinium; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D015609:Organotechnetium Compounds; D011859:Radiography; D019275:Radiopharmaceuticals; D012446:Sacroiliac Joint / Q000000981:diagnostic imaging; D025241:Spondylarthritis / Q000175:diagnosis / Q000000981:diagnostic imaging*; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology*
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D003287:Contrast Media; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D014409:Tumor Necrosis Factor-alpha; D005682:Gadolinium; D000068879:Adalimumab