title: Chemical constitution and effect of extracts of tomato plants byproducts on the enteric viral surrogates.
abstract: Byproducts of tomato are known to include phenolic compounds but have not been studied in depth. In this study, the phenolic compositions of (stem, leaf, root, and whole plant) of two tomato cultivars, Pitenza and Floradade, were analyzed by HPLC-DAD. In parallel, the antiviral effects of crude extracts on viral surrogates, the bacteriophages MS2 and Av-05 were evaluated. The leaf extracts from the two varieties showed the highest concentration of phenolic compounds. The compounds identified were gallic acid, chlorogenic acid, ferulic acid, cafeic acid, rutin, and quercetin, and they represented 3174.3 and 1057.9 mg/100 g dried weight of the Pitenza and Floradade cultivars, respectively. MS2 and Av-05 titers at 5 mg/mL were reduced by 3.47 and 5.78 log10 PFU/mL and 3.78 and 4.93 log10 PFU/mL by Pitenza and Floradade cultivar leaf extract, respectively. These results show that tomato extracts are natural sources of bioactive substances with antiviral activity.
authors: a Instituto Tecnológico de Sonora, Departamento de Biotecnología y Ciencias Alimentarias , Ciudad Obregón , Mexico.
authors: Norma Patricia
authors: NP
authors: Silva-Beltrán
authors: Saul
authors: S
authors: Ruiz-Cruz
authors: Cristobal
authors: C
authors: Chaidez
authors: José de Jesús
authors: Jde J
authors: Ornelas-Paz
authors: Marco A
authors: MA
authors: López-Mata
authors: Enrique
authors: E
authors: Márquez-Ríos
authors: Maria Isabel
authors: MI
authors: Estrada
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D001435:Bacteriophages / Q000187:drug effects; D002726:Chlorogenic Acid / Q000032:analysis; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003373:Coumaric Acids / Q000032:analysis; D005707:Gallic Acid / Q000032:analysis; D017909:Levivirus / Q000187:drug effects; D018551:Solanum lycopersicum / Q000737:chemistry*; D010636:Phenols / Q000032:analysis; D010936:Plant Extracts / Q000032:analysis / Q000737:chemistry* / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D011794:Quercetin / Q000032:analysis; D012431:Rutin / Q000032:analysis
chemical_list: D000998:Antiviral Agents; D003373:Coumaric Acids; D010636:Phenols; D010936:Plant Extracts; D002726:Chlorogenic Acid; D012431:Rutin; D005707:Gallic Acid; D011794:Quercetin; C004999:ferulic acid
keywords: bacteriophages; extracts; polyphenols; tomato byproducts