title: Evaluation of the anti-depressant activity of Myristica fragrans (Nutmeg) in male rats.
abstract: OBJECTIVE
  The present study was undertaken to evaluate anti-depressant activity of Myristica fragrans (MS).
  
  
  METHODS
  Male Wistar rats were subjected to imipramine and herbal extract of MS for their antidepressant activity using Forced Swimming Test (FST), Reserpine Reversal Test (RRT), Haloperidol-Induced Catalepsy (HIC), and Pentobarbitone Sleeping Time (PST).
  
  
  RESULTS
  Administration of MS and imipramine revealed a statistically significant reduction in immobility time in FST, RRT, and protection against HIC, compared to the control group. However, there was no significant potentiation of PST.
  
  
  CONCLUSIONS
  Our study demonstrated the potential antidepressant activity of MS.
authors: Department of Pharmacology, Al-Ameen College of Pharmacy, Near Lalbagh Main Gate, Bangalore-560027. India.
authors: Ghulam
authors: G
authors: Moinuddin
authors: Department of Pharmacology, Al-Ameen College of Pharmacy, Near Lalbagh Main Gate, Bangalore-560027. India.
authors: Kshama
authors: K
authors: Devi
authors: Department of Pharmacology, Al-Ameen College of Pharmacy, Near Lalbagh Main Gate, Bangalore-560027. India.
authors: Deepak
authors: D
authors: Kumar Khajuria
keywords: Antidepressant activity; Imipramine; Myristica fragrans