title: Sumoylation modulates oxidative stress relevant to the viability and functionality of pancreatic beta cells.
abstract: Sumoylation is an evolutionarily conserved regulatory mechanism to play an important role in various cellular processes through modulation of protein localization, stability and functionality. Recent studies including ours have consistently demonstrated that sumoylation provides protection for cells against oxidative stress. Given that pancreatic beta cells are a vulnerable target of oxidative stress, we thus in this minireview, updated the advancement of sumoylation in the regulation of ROS generation, and discussed its impact on several critical signaling pathways relevant to beta cells against oxidative stress and maintenance of functionality. Specifically, we bring together how sumoylation represses intracellular ROS formation, and protects beta cells against oxidative stress through regulating IκB/NFκB, JNK/c-Jun, and Maf/Nrf2 pathways. The tight implication of sumoylation in oxidative stress reflects that it could be an essential mechanism for beta cells to adapt to the detrimental cellular microenvironment.
authors: The Center for Biomedical Research, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology 1095 Jiefang Ave., Wuhan 430030, China.
authors: Ping
authors: P
authors: Yang
authors: The Center for Biomedical Research, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology 1095 Jiefang Ave., Wuhan 430030, China.
authors: Shuang
authors: S
authors: Hu
authors: Department of Immunology, Medical College of Yangtze University 55 Jianghan Road, Jingzhou, Hubei 434023, China.
authors: Fei
authors: F
authors: Yang
authors: Department of Clinical Immunology, Institute of Laboratory Medicine, Guangdong Medical College Dongguan 523808, China.
authors: Xiang-Qian
authors: XQ
authors: Guan
authors: Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Cardiovascular Institute Guangzhou 510080, China.
authors: Shi-Qiang
authors: SQ
authors: Wang
authors: Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Cardiovascular Institute Guangzhou 510080, China.
authors: Ping
authors: P
authors: Zhu
authors: The Center for Biomedical Research, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology 1095 Jiefang Ave., Wuhan 430030, China.
authors: Fei
authors: F
authors: Xiong
authors: The Center for Biomedical Research, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology 1095 Jiefang Ave., Wuhan 430030, China.
authors: Shu
authors: S
authors: Zhang
authors: Department of Clinical Immunology, Institute of Laboratory Medicine, Guangdong Medical College Dongguan 523808, China.
authors: Junfa
authors: J
authors: Xu
authors: The Center for Biomedical Research, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology 1095 Jiefang Ave., Wuhan 430030, China.
authors: Qi-Lin
authors: QL
authors: Yu
authors: The Center for Biomedical Research, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology 1095 Jiefang Ave., Wuhan 430030, China ; Department of Immunology, Medical College of Yangtze University 55 Jianghan Road, Jingzhou, Hubei 434023, China ; Department of Clinical Immunology, Institute of Laboratory Medicine, Guangdong Medical College Dongguan 523808, China.
authors: Cong-Yi
authors: CY
authors: Wang
keywords: ROS; Sumoylation; beta cell; diabetes; oxidative stress