title: Association of soluble HLA-G with acute rejection episodes and early development of bronchiolitis obliterans in lung transplantation.
abstract: Lung transplantation has evolved into a life-saving therapy for select patients with end-stage lung diseases. However, long-term survival remains limited because of bronchiolitis obliterans syndrome (BOS). Soluble HLA-G, a mediator of adaptive immunity that modulates regulatory T cells and certain classes of effector T cells, may be a useful marker of survival free of BOS. We conducted a retrospective, single-center, pilot review of 38 lung transplant recipients who underwent collection of serum and bronchoalveolar lavage fluid 3, 6 and 12 months after transplantation, and compared soluble HLA-G concentrations in each to the presence of type A rejection and lymphocytic bronchiolitis in the first 12 months and to the presence of BOS at 24 months after transplantation. Lung soluble HLA-G concentrations were directly related to the presence of type A rejection but not to lymphocytic bronchiolitis. Our data demonstrate that soluble HLA-G concentrations in bronchoalveolar lavage but not in serum correlates with the number of acute rejection episodes in the first 12 months after lung transplantation, and thus may be a reactive marker of rejection.
authors: Departments of Medicine and Health Studies, University of Chicago, Chicago, Illinois, United States of America.
authors: Steven R
authors: SR
authors: White
authors: Departments of Medicine and Health Studies, University of Chicago, Chicago, Illinois, United States of America.
authors: Timothy
authors: T
authors: Floreth
authors: Departments of Medicine and Health Studies, University of Chicago, Chicago, Illinois, United States of America.
authors: Chuanhong
authors: C
authors: Liao
authors: Department of Medicine, Northwestern University, Chicago, Illinois, United States of America.
authors: Sangeeta M
authors: SM
authors: Bhorade
mesh_terms: D000208:Acute Disease; D000368:Aged; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D001989:Bronchiolitis Obliterans / Q000175:diagnosis* / Q000209:etiology / Q000276:immunology; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry / Q000276:immunology; D005260:Female; D006084:Graft Rejection / Q000175:diagnosis* / Q000209:etiology / Q000276:immunology; D059951:HLA-G Antigens / Q000032:analysis* / Q000097:blood / Q000276:immunology; D006801:Humans; D016040:Lung Transplantation / Q000009:adverse effects / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis* / Q000209:etiology / Q000276:immunology; D012189:Retrospective Studies; D012995:Solubility; D013997:Time Factors
chemical_list: D015415:Biomarkers; D059951:HLA-G Antigens