title: Extract of Irish potatoes (Solanum tuberosum L.) decreases body weight gain and adiposity and improves glucose control in the mouse model of diet-induced obesity.
abstract: Both sexes of mice were fed a high fat diet (HFD) for 10 weeks without and with polyphenolic-rich potato extracts (PRPE) of cultivars Onaway and Russet Burbank. PRPE attenuated weight gain in male and female mice by as much as 63.2%, which was associated mostly with a reduction in adiposity. Mice receiving PRPE showed enhanced capacity for blood glucose clearance. Sex differences regarding the impact of HFD and PRPE on plasma levels of insulin, ghrelin, leptin, gastric inhibitory peptide, and resistin were noted. PRPE may serve as part of a preventative dietary strategy against the development of obesity and type 2 diabetes.
authors: School of Dietetics and Human Nutrition, McGill University, QC, Canada.
authors: Stan
authors: S
authors: Kubow
authors: Luc
authors: L
authors: Hobson
authors: Michèle M
authors: MM
authors: Iskandar
authors: Kebba
authors: K
authors: Sabally
authors: Danielle J
authors: DJ
authors: Donnelly
authors: Luis B
authors: LB
authors: Agellon
mesh_terms: D050154:Adiposity / Q000187:drug effects*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D059305:Diet, High-Fat / Q000009:adverse effects; D004195:Disease Models, Animal; D005260:Female; D005749:Gastric Inhibitory Polypeptide / Q000097:blood; D054439:Ghrelin / Q000097:blood; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000188:drug therapy; D010936:Plant Extracts / Q000494:pharmacology*; D059808:Polyphenols / Q000494:pharmacology; D052243:Resistin / Q000097:blood; D011198:Solanum tuberosum / Q000737:chemistry*; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D001786:Blood Glucose; D054439:Ghrelin; D007328:Insulin; D020738:Leptin; D010936:Plant Extracts; D059808:Polyphenols; D052243:Resistin; D005749:Gastric Inhibitory Polypeptide
keywords: Glucose tolerance; Polyphenols; Potato; Sex differences