title: Thermally-Induced Substrate Release Via Intramolecular Cyclizations of Amino Esters and Amino Carbonates.
abstract: The relative cleavage of an alcohol from a panel of amino esters and amino carbonates via intramolecular cyclization was examined as a mechanism for substrate release. Thermal stability at 37 °C was observed only for the 7-membered ring progenitors. Applicability of the approach was illustrated by δ-lactam formation within a poly(dimethylsiloxane) microchannel for release of a captured fluorescent probe.
authors: Department of Chemistry, University of Louisville, Louisville, KY 40292, USA.
authors: Ralph J
authors: RJ
authors: Knipp
authors: Department of Bioengineering, University of Louisville, Louisville, KY 40292, USA.
authors: Rosendo
authors: R
authors: Estrada
authors: Department of Bioengineering, University of Louisville, Louisville, KY 40292, USA.
authors: Palaniappan
authors: P
authors: Sethu
authors: Department of Chemistry, University of Louisville, Louisville, KY 40292, USA.
authors: Michael H
authors: MH
authors: Nantz
keywords: drug delivery; lactam; oxazolidinone; poly(dimethylsiloxane) microchannel