title: Mg- and/or Sr-doped tricalcium phosphate/bioactive glass composites: synthesis, microstructure and biological responsiveness.
abstract: Presently, there is an increasing interest towards the composites of calcium phosphates, especially β-tricalcium phosphate (TCP), and bioactive glasses. In the present contribution, the recently developed BG_Ca/Mix glass has been used because its low tendency to crystallize allows to sinter the composites at relatively low temperature (i.e. 850°C), thus minimizing the glass devitrification and the interaction with TCP. A further improvement is the introduction of lab-produced TCP powders doped with specific ions instead of non-doped commercial powders, since the biological properties of materials for bone replacement can be modulated by doping them with certain metallic ions, such as Mg and Sr. Therefore, novel binary composites have been produced by sintering the BG_Ca/Mix glass with the addition of pure, Mg-substituted, Sr-substituted or Mg/Sr bisubstituted TCP powders. After an accurate characterization of the starting TCP powders and of the obtained samples, the composites have been used as three-dimensional supports for the culture of mouse calvaria-derived pre-osteoblastic cells. The samples supported cell adhesion and proliferation and induced promising mechanisms of differentiation towards an osteoblastic phenotype. In particular, the Mg/Sr bi-doped samples seemed to better promote the differentiation process thus suggesting a combined stimulatory effect of Mg(2+) and Sr(2+) ions.
authors: Department of Engineering "E. Ferrari", University of Modena and Reggio Emilia, Via Vignolese 905, 41125 Modena, Italy. Electronic address: devis.bellucci@unimore.it.
authors: Devis
authors: D
authors: Bellucci
authors: Department of Engineering "E. Ferrari", University of Modena and Reggio Emilia, Via Vignolese 905, 41125 Modena, Italy.
authors: Antonella
authors: A
authors: Sola
authors: University of Rome "Niccolò Cusano", UdR INSTM, Via Don Carlo Gnocchi 3, 00166, Rome, Italy.
authors: Ilaria
authors: I
authors: Cacciotti
authors: Department of Chemistry and Industrial Chemistry, University of Pisa, UdR INSTM - Pisa, Via Risorgimento 35, 56127 Pisa, Italy.
authors: Cristina
authors: C
authors: Bartoli
authors: Department of Chemistry and Industrial Chemistry, University of Pisa, UdR INSTM - Pisa, Via Risorgimento 35, 56127 Pisa, Italy.
authors: Matteo
authors: M
authors: Gazzarri
authors: Department of Enterprise Engineering, INSTM RU "Rome-Tor Vergata", Via del Politecnico 1, 00133 Roma, Italy.
authors: Alessandra
authors: A
authors: Bianco
authors: Department of Chemistry and Industrial Chemistry, University of Pisa, UdR INSTM - Pisa, Via Risorgimento 35, 56127 Pisa, Italy.
authors: Federica
authors: F
authors: Chiellini
authors: Department of Engineering "E. Ferrari", University of Modena and Reggio Emilia, Via Vignolese 905, 41125 Modena, Italy.
authors: Valeria
authors: V
authors: Cannillo
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology*; D002130:Calcium Phosphates / Q000737:chemistry*; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D005898:Glass / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008274:Magnesium / Q000737:chemistry*; D051379:Mice; D010006:Osteoblasts; D013324:Strontium / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D002130:Calcium Phosphates; D008274:Magnesium; C018392:tricalcium phosphate; D013324:Strontium
keywords: Bioactive glass; Composites; Dopants; Magnesium; Strontium; β-Tricalcium phosphate