title: A review on anticancer potential of bioactive heterocycle quinoline.
abstract: The advent of Camptothecin added a new dimension in the field anticancer drug development containing quinoline motif. Quinoline scaffold plays an important role in anticancer drug development as their derivatives have shown excellent results through different mechanism of action such as growth inhibitors by cell cycle arrest, apoptosis, inhibition of angiogenesis, disruption of cell migration, and modulation of nuclear receptor responsiveness. The anti-cancer potential of several of these derivatives have been demonstrated on various cancer cell lines. In this review we have compiled and discussed specifically the anticancer potential of quinoline derivatives, which could provide a low-height flying bird's eye view of the quinoline derived compounds to a medicinal chemist for a comprehensive and target oriented information for development of clinically viable anticancer drugs.
authors: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi 110062, India.
authors: Obaid
authors: O
authors: Afzal
authors: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi 110062, India.
authors: Suresh
authors: S
authors: Kumar
authors: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi 110062, India.
authors: Md Rafi
authors: MR
authors: Haider
authors: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi 110062, India.
authors: Md Rahmat
authors: MR
authors: Ali
authors: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi 110062, India.
authors: Rajiv
authors: R
authors: Kumar
authors: Dabur Research Foundation, Ghaziabad, Uttar Pradesh, India.
authors: Manu
authors: M
authors: Jaggi
authors: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi 110062, India. Electronic address: drsbawa@rediffmail.com.
authors: Sandhya
authors: S
authors: Bawa
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D011804:Quinolines / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D011804:Quinolines; C037219:quinoline
keywords: Anticancer; Drug development; Quinoline