title: Expression of Toll-like receptors 7-10 in human fallopian tubes.
abstract: BACKGROUND
  The human female reproductive tract (FRT) is constantly deal with the invading pathogens. Recognition of these pathogens is attributed to the family of Toll like receptors (TLR) as a major part of the innate immune system. We and others have previously revealed that TLRs1-6 express in the female reproductive tract. However, more studies should be done to detect TLRs 7-10 in the female reproductive tract, especially in the fallopian tubes.
  
  
  OBJECTIVE
  To examine the expression of TLRs7-10 in human fallopian tube tissue.
  
  
  METHODS
  Using immunostaining techniques, distribution of TLR7-10 was studied in surgical sections from the uterine tubes, obtained from patients undergoing tubal ligation and hysterectomy for benign gynecological conditions. RT-PCR was used to show the existence of TLR7-10 genes in fallopian tube tissue.
  
  
  RESULTS
  TLR7-10 proteins were detected in the fallopian tube epithelium, although the intensity of staining was not equal in cases. TLR7-10 genes were expressed in human fallopian tube tissue.
  
  
  CONCLUSIONS
  This study indicates that TLR7-10 is expressed in fallopian tubes tissues, and may play an important role in microbial recognition, and in host defense against ascending infection.
authors: Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors: Nasrin
authors: N
authors: Ghasemi
authors: Department of Anatomy, Tehran University of Medical Sciences, Tehran, Iran.
authors: Fatemehsadat
authors: F
authors: Amjadi
authors: Department of Anatomy, Tehran University of Medical Sciences, Tehran, Iran.
authors: Ensieh
authors: E
authors: Salehi
authors: Tehran Islamic Azad University of Medical Sciences, Tehran, Iran.
authors: Mojgan
authors: M
authors: Shakeri
authors: Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors: Abbas
authors: A
authors: Aflatoonian
authors: Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
authors: Reza
authors: R
authors: Aflatoonian
keywords: Fallopian tube; Innate immunity; Reproductive medicine; Toll like receptors (TLRs)