title: Surgical outcomes of malignant sinonasal tumours: open versus endoscopic surgical approaches.
abstract: BACKGROUND
  Sinonasal malignancies are rare tumours, which can be resected using an open or endoscopic approach. The current study evaluated the outcome of both approaches.
  
  
  METHODS
  A total of 160 patients with malignant nasal tumours were evaluated in an academic tertiary care hospital. The patients were allocated to 'open' or 'endoscopic' surgery groups, based on the surgical approach employed. The following data were evaluated and compared: patient and tumour characteristics; oncological treatments; and oncological outcomes, including complications, surgical margin, recurrence, overall survival and disease-free survival.
  
  
  RESULTS
  The maxillary sinus was the most common tumour location and squamous cell carcinoma was the most common histopathology-based diagnosis. Younger patients had lower grades of tumour. Higher survival rates were significantly related to lower tumour stages in both surgery groups. There were no differences between the two relatively similar groups in terms of surgical margin, the need for adjunctive therapy, and recurrence and survival rates. In addition, multivariate logistical regression analysis indicated no correlations between the type of surgical approach employed and the rates of recurrence and complications.
  
  
  CONCLUSIONS
  Endoscopic surgery for sinonasal malignancies is comparable to the conventional open approach in carefully selected patients.
authors: Department of ENT,Otolaryngology Research Center,Imran Khomeini Medical Center,Tehran University of Medical Sciences,Tehran,Iran.
authors: B
authors: B
authors: Saedi
authors: Department of ENT,Otolaryngology Research Center,Imran Khomeini Medical Center,Tehran University of Medical Sciences,Tehran,Iran.
authors: M
authors: M
authors: Aghili
authors: Department of ENT,Otolaryngology Research Center,Imran Khomeini Medical Center,Tehran University of Medical Sciences,Tehran,Iran.
authors: M
authors: M
authors: Motiee
authors: Department of ENT,Otolaryngology Research Center,Imran Khomeini Medical Center,Tehran University of Medical Sciences,Tehran,Iran.
authors: S
authors: S
authors: Valadkhani
authors: Department of ENT,Otolaryngology Research Center,Imran Khomeini Medical Center,Tehran University of Medical Sciences,Tehran,Iran.
authors: A B
authors: AB
authors: Niazi
authors: Department of ENT,Otolaryngology Research Center,Imran Khomeini Medical Center,Tehran University of Medical Sciences,Tehran,Iran.
authors: A
authors: A
authors: Safavi
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000401:mortality / Q000601:surgery; D002648:Child; D015331:Cohort Studies; D004724:Endoscopy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000601:surgery; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D009367:Neoplasm Staging; D009669:Nose Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D011183:Postoperative Complications / Q000453:epidemiology*; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D016896:Treatment Outcome; D055815:Young Adult