title: Phosphate-dependent glutaminase response to liver injury and hyperbaric oxygenation.
abstract: Activity of phosphate-dependent glutaminase was determined in hepatocytes of white female rats, both in healthy animals and in rats with chronic CCl4-hepatitis on day 3 after liver resection and hyperbaric oxygenation. In healthy animals, activity of phosphate-dependent glutaminase was not altered after hepatic resection, but it was elevated in animals with chronic CCl4-hepatitis. Hyperbaric oxygenation inhibited activity of hepatocytic phosphate-dependent glutaminase in non-operated healthy rats but stimulated it after hepatic resection. In animals with chronic CCl4-hepatitis; hyperbaric oxygenation restricted the stimulating effect of hepatic resection on phosphate-dependent glutaminase activity.
authors: Department of Normal Physiology, N. N. Burdenko Voronezh State Medical Academy, the Ministry of Health of the Russian Federation, Voronezh, Russia.
authors: P N
authors: PN
authors: Savilov
authors: V N
authors: VN
authors: Yakovlev
mesh_terms: D000818:Animals; D002251:Carbon Tetrachloride; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology* / Q000628:therapy; D005260:Female; D005972:Glutaminase / Q000378:metabolism*; D006498:Hepatectomy; D006521:Hepatitis, Chronic / Q000201:enzymology / Q000628:therapy; D006931:Hyperbaric Oxygenation; D008099:Liver / Q000201:enzymology* / Q000473:pathology; D008930:Mitochondria, Liver / Q000201:enzymology; D051381:Rats
chemical_list: D002251:Carbon Tetrachloride; D005972:Glutaminase