title: Structural studies of DNA end detection and resection in homologous recombination.
abstract: DNA double-strand breaks are repaired by two major pathways, homologous recombination or nonhomologous end joining. The commitment to one or the other pathway proceeds via different steps of resection of the DNA ends, which is controlled and executed by a set of DNA double-strand break sensors, endo- and exonucleases, helicases, and DNA damage response factors. The molecular choreography of the underlying protein machinery is beginning to emerge. In this review, we discuss the early steps of genetic recombination and double-strand break sensing with an emphasis on structural and molecular studies.
authors: Department of Biochemistry and Gene Center, Ludwig-Maximilians-University, 81377 Munich, Germany.
authors: Christian Bernd
authors: CB
authors: Schiller
authors: Department of Biochemistry and Gene Center, Ludwig-Maximilians-University, 81377 Munich, Germany.
authors: Florian Ulrich
authors: FU
authors: Seifert
authors: Department of Biochemistry and Gene Center, Ludwig-Maximilians-University, 81377 Munich, Germany.
authors: Christian
authors: http://orcid.org/0000-0002-2306-247X
authors: C
authors: Linke-Winnebeck
authors: Department of Biochemistry and Gene Center, Ludwig-Maximilians-University, 81377 Munich, Germany Center for Integrated Protein Sciences, 81377 Munich, Germany.
authors: Karl-Peter
authors: KP
authors: Hopfner
mesh_terms: D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair; D059765:Homologous Recombination / Q000235:genetics*; D006801:Humans; D008957:Models, Genetic; D015398:Signal Transduction