title: Risk factors for anthelmintic resistance development in cattle gastrointestinal nematodes in Argentina.
abstract: Risk factors for anthelmintic resistance (AR) on bovine ranches were studied. Data were derived from a survey made to 50 ranch owners, who had conducted a faecal egg-count-reduction test. The questionnaire contained descriptors of bovine ranch management and nematode control. A case-control design study was undertaken and AR cases were present in 26 herds. Associations between the binary outcome variable (AR versus not AR) and risk factors recorded in the questionnaire were evaluated. Variables associated with the presence of AR at P< 0.15 and/or odds ratio (OR) > 2 were subjected to a multivariable logistic regression model. The main effects contributing to general AR (avermectin AVM and/or benzimidazole) in the final model were total number of annual treatments (OR 7.68; 95% CI 2.4 to 28.3) and use of more than 75% of AVM in the past (OR= 18.6; 95% CI 1.3 to 97.3), whereas for AVM resistance alone were total number of AVM annual treatments (OR= 11.5; 95% CI 2.9 to 45.5) and number of AVM Nov-Jan treatments (OR= 5.8; 95% CI 1.71 to 47.9). The results showed that treatment frequency, date of treatment and frequency of treatment in the past with a single drug were the main risk factors involved in AR development.
authors: Laboratório de Parasitología, Unidad de Salud Animal Estación Experimental Agropecuaria Salta, INTA, Cerrillos, Salta, Argentina.
authors: Víctor Humberto
authors: VH
authors: Suarez
authors: Unidad de Salud Animal Estación Experimental Agropecuaria G. Covas, INTA, Anguil, La Pampa, Argentina.
authors: Silvina Lujan
authors: SL
authors: Cristel
mesh_terms: D000383:Agriculture; D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology* / Q000627:therapeutic use; D001118:Argentina; D002417:Cattle / Q000469:parasitology*; D002418:Cattle Diseases / Q000188:drug therapy / Q000469:parasitology / Q000517:prevention & control; D004351:Drug Resistance; D041981:Gastrointestinal Tract / Q000469:parasitology*; D009348:Nematoda / Q000187:drug effects*; D012307:Risk Factors; D011795:Surveys and Questionnaires
chemical_list: D000871:Anthelmintics