title: Apolipoprotein polymorphism is associated with pro-thrombotic profile in non-demented dyslipidemic subjects.
abstract: Apolipoprotein gene polymorphism has an important role in lipid metabolism and in the development of cerebro- and cardio-vascular disease (CCVD), including dementia. Dyslipidemia and hemostatic abnormalities are key risk factors associated with athero-sclerotic events preceding CCVD. The aim of this study was to evaluate the possible relationships of various apolipoprotein-species with hemostatic parameters and cognitive function. Lipid profile, gene polymorphism, coagulation markers, and mini-mental state examination (MMSE) scores were assessed in 109 dys-lipidemic subjects and in 107 healthy control volunteers. Thrombin-activatable fibrinolysis inhibitor (TAFI) plasma levels were significantly higher in apolipoprotein-E2 (apoE2) patients when compared to other apoE forms. The apoA5 -1131T>C polymorphism was associated with elevated D-dimer concentration in dyslipidemic TT homozygous individuals. MMSE did not correlate with lipid or coagulation profile. These data suggest that apoE and apoA5 variants have an effect on hemostatic parameters, but they neither influence nor predict cognitive performance in non-demented individuals.
authors: Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901, Brazil.
authors: Cláudia N
authors: CN
authors: Ferreira
authors: Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901, Brazil.
authors: Maria G
authors: MG
authors: Carvalho
authors: Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901, Brazil.
authors: Karina B
authors: KB
authors: Gomes
authors: Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901, Brazil.
authors: Helton J
authors: HJ
authors: Reis
authors: Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901, Brazil.
authors: Ana-Paula
authors: AP
authors: Fernandes
authors: Asklepios-Med (private medical practice and research center), Szeged, H-6722, Hungary palotas@asklepios-med.eu.
authors: András
authors: A
authors: Palotás
authors: Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901, Brazil.
authors: Marinez O
authors: MO
authors: Sousa
mesh_terms: D000328:Adult; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D003704:Dementia / Q000453:epidemiology / Q000235:genetics; D050171:Dyslipidemias / Q000150:complications*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D013927:Thrombosis / Q000453:epidemiology* / Q000235:genetics*
chemical_list: C437704:APOA5 protein, human; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A; D001057:Apolipoproteins E
keywords: Apolipoprotein-A5 (apoA5); D-dimer; apolipoprotein-E (apoE); cerebro- and cardio-vascular disease (CCVD); cognitive performance; dementia; dyslipidemia; gene polymorphism; thrombin-activatable fibrinolysis inhibitor (TAFI)