title: Palladium-Catalyzed Intra- and Intermolecular C-H Arylation Using Mesylates: Synthetic Scope and Mechanistic Studies.
abstract: This paper describes the development of Pd-catalyzed inter- and intramolecular direct arylation using mesylates. Furthermore, a sequential mesylation/arylation protocol using phenols as substrates is described. These transformations are general with respect to the electronics of the C-H substrates and allow for the synthesis of diverse heterocyclic motifs in good yields. Both arenes and heteroarenes efficiently participate in these reactions. Preliminary mechanistic studies are presented for both inter- and intramolecular arylations.
authors: Department of Chemistry, St. Olaf College , 1520 St. Olaf Ave, Northfield, Minnesota 55057, United States.
authors: Devin M
authors: DM
authors: Ferguson
authors: Department of Chemistry, St. Olaf College , 1520 St. Olaf Ave, Northfield, Minnesota 55057, United States.
authors: Stacey R
authors: SR
authors: Rudolph
authors: Department of Chemistry, St. Olaf College , 1520 St. Olaf Ave, Northfield, Minnesota 55057, United States.
authors: Dipannita
authors: D
authors: Kalyani
keywords: C−H activation; arylation; homogeneous catalysis; mesylates; palladium