title: Response to chemotherapy is not related to chromosome instability in synovial sarcoma.
abstract: BACKGROUND
  Synovial sarcoma (SS) is an aggressive soft-tissue tumor. Despite being considered as a chemosensitive disease, the real impact of perioperative chemotherapy on metastasis-free survival (MFS) is controversial. We have shown that metastatic relapse of SS is strongly associated with genomic complexity. There are no data regarding the potential correlation between genomic complexity and response to chemotherapy.
  
  
  METHODS
  The study population included 65 SS patients diagnosed between 1991 and 2013 and with available tissue material. Genomic profiling was carried out by using array-CGH. Forty-five SS out of the 65 patients were treated with neoadjuvant anthracycline/ifosfamide-based chemotherapy. Radiological response was assessed according to RECIST criteria. Histological response was defined by the percentage of recognizable tumor cells on the surgical specimen.
  
  
  RESULTS
  Genomic complexity was significantly associated with MFS. However, there was no statistically significant association between radiological or histological response and genomic complexity.
  
  
  CONCLUSIONS
  The absence of significant association between response to chemotherapy and genomic complexity suggests that the prognostic value of chromosome instability in SS is independent of response to chemotherapy; mechanisms leading to metastatic relapse of SS are intrinsic to the biology of the tumor and current cytotoxic drugs are only poorly efficient to prevent it.
authors: Department of Medical Oncology, Institut Bergonié; Université Victor Segalen Bordeaux 2; Institut National de la Santé et de la Recherche Medicale (INSERM), U916-Institut Bergonié.
authors: C
authors: C
authors: Chakiba
authors: Université Victor Segalen Bordeaux 2; Institut National de la Santé et de la Recherche Medicale (INSERM), U916-Institut Bergonié; Department of Pathology, Institut Bergonié, Bordeaux.
authors: P
authors: P
authors: Lagarde
authors: Department of Pathology, Centre Léon Bérard, Lyon.
authors: D
authors: D
authors: Pissaloux
authors: Université Victor Segalen Bordeaux 2; Institut National de la Santé et de la Recherche Medicale (INSERM), U916-Institut Bergonié; Department of Pathology, Institut Bergonié, Bordeaux.
authors: A
authors: A
authors: Neuville
authors: Institut National de la Santé et de la Recherche Medicale (INSERM), U916-Institut Bergonié.
authors: C
authors: C
authors: Brulard
authors: Institut National de la Santé et de la Recherche Medicale (INSERM), U916-Institut Bergonié; Department of Pathology, Institut Bergonié, Bordeaux.
authors: G
authors: G
authors: Pérot
authors: Université Victor Segalen Bordeaux 2; Institut National de la Santé et de la Recherche Medicale (INSERM), U916-Institut Bergonié; Department of Pathology, Institut Bergonié, Bordeaux.
authors: J M
authors: JM
authors: Coindre
authors: Department of Pathology, Institut Gustave Roussy, Villejuif, France.
authors: P
authors: P
authors: Terrier
authors: Department of Pathology, Centre Léon Bérard, Lyon.
authors: D
authors: D
authors: Ranchere-Vince
authors: Department of Medical Oncology.
authors: A
authors: A
authors: Ferrari
authors: Department of Pathology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
authors: P
authors: P
authors: Collini
authors: Department of Pathology, University of Groningen University Medical Center, Groningen, The Netherlands.
authors: A J H
authors: AJH
authors: Suurmeijer
authors: Department of Medical Oncology, Centre Léon Berard, Lyon.
authors: J Y
authors: JY
authors: Blay
authors: Department of Medical Oncology, Institut Gustave Roussy, Villejuif.
authors: S A
authors: SA
authors: Terrisse
authors: Department of Medical Oncology, Institut Curie, Paris.
authors: S
authors: S
authors: Piperno-Neumann
authors: Department of Pathology, Centre Hospitalier Universitaire Hautepierre, Strasbourg.
authors: G
authors: G
authors: Averous
authors: Department of Medical Oncology, Institut Bergonié; Institut National de la Santé et de la Recherche Medicale (INSERM), U916-Institut Bergonié.
authors: B
authors: B
authors: Bui
authors: Department of Pediatric Oncoloy, Institut Curie, Paris, France.
authors: D
authors: D
authors: Orbach
authors: Department of Medical Oncology, Institut Bergonié; Institut National de la Santé et de la Recherche Medicale (INSERM), U916-Institut Bergonié.
authors: A
authors: A
authors: Italiano
authors: Institut National de la Santé et de la Recherche Medicale (INSERM), U916-Institut Bergonié; Department of Pathology, Institut Bergonié, Bordeaux. Electronic address: f.chibon@bordeaux.unicancer.fr.
authors: F
authors: F
authors: Chibon
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D043171:Chromosomal Instability / Q000235:genetics*; D005260:Female; D015894:Genome, Human; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D011379:Prognosis; D013584:Sarcoma, Synovial / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology
chemical_list: D007069:Ifosfamide
keywords: chemotherapy; genomic index; prognosis; synovial sarcoma