title: Association of μ-Opioid Activation in the Prefrontal Cortex with Spontaneous Migraine Attacks - Brief Report I.
abstract: We evaluatedin vivothe μ-opioid system during spontaneous episodic migraine headaches. Seven patients were scanned at different phases of their migraine using Positron Emission Tomography with the selective μ-opioid receptor (μOR) radiotracer [11C]carfentanil. In the ictal phase, there was μOR activation in the medial prefrontal cortex, which was strongly associated with the μOR availability level during the interictal phase. Furthermore, μ-opioid binding changes showed moderate negative correlation with the combined extension and severity of the attacks. These results indicate for the first time that there is high μOR activation in the migraineurs' brains during headache attacks in response to their pain.
authors: Headache and Orofacial Pain Effort (HOPE), Biologic and Materials Sciences Department, School of Dentistry, University of Michigan, Ann Arbor, MI, United States ; Michigan Center for Oral Health Research (MCOHR), School of Dentistry, University of Michigan, Ann Arbor, MI, United States ; Translational Neuroimaging Laboratory, Molecular and Behavioral Neuroscience Institute (MBNI), University of Michigan, Ann Arbor, MI, United States.
authors: Alexandre F
authors: AF
authors: DaSilva
authors: Headache and Orofacial Pain Effort (HOPE), Biologic and Materials Sciences Department, School of Dentistry, University of Michigan, Ann Arbor, MI, United States.
authors: Thiago D
authors: TD
authors: Nascimento
authors: Headache and Orofacial Pain Effort (HOPE), Biologic and Materials Sciences Department, School of Dentistry, University of Michigan, Ann Arbor, MI, United States.
authors: Marcos F
authors: MF
authors: DosSantos
authors: Headache and Orofacial Pain Effort (HOPE), Biologic and Materials Sciences Department, School of Dentistry, University of Michigan, Ann Arbor, MI, United States.
authors: Sarah
authors: S
authors: Lucas
authors: Headache and Orofacial Pain Effort (HOPE), Biologic and Materials Sciences Department, School of Dentistry, University of Michigan, Ann Arbor, MI, United States.
authors: Hendrik
authors: H
authors: van HolsbeecK
authors: Headache and Orofacial Pain Effort (HOPE), Biologic and Materials Sciences Department, School of Dentistry, University of Michigan, Ann Arbor, MI, United States.
authors: Misty
authors: M
authors: DeBoer
authors: 3DLab, University of Michigan.
authors: Eric
authors: E
authors: Maslowski
authors: Translational Neuroimaging Laboratory, Molecular and Behavioral Neuroscience Institute (MBNI), University of Michigan, Ann Arbor, MI, United States.
authors: Tiffany
authors: T
authors: Love
authors: Headache and Orofacial Pain Effort (HOPE), Biologic and Materials Sciences Department, School of Dentistry, University of Michigan, Ann Arbor, MI, United States ; Translational Neuroimaging Laboratory, Molecular and Behavioral Neuroscience Institute (MBNI), University of Michigan, Ann Arbor, MI, United States.
authors: Ilkka K
authors: IK
authors: Martikainen
authors: PET Physics Section, Division of Nuclear Medicine, Radiology Department, University of Michigan.
authors: Robert A
authors: RA
authors: Koeppe
authors: Department of Obstetrics and Gynecology, University of Michigan.
authors: Yolanda R
authors: YR
authors: Smith
authors: Translational Neuroimaging Laboratory, Molecular and Behavioral Neuroscience Institute (MBNI), University of Michigan, Ann Arbor, MI, United States.
authors: Jon-Kar
authors: JK
authors: Zubieta