title: Epigenetic remodeling combined with photodynamic therapy elicits anticancer immune responses.
abstract: Photodynamic therapy has been shown to induce strong immunity against tumor cells expressing exogenous tumor-associated antigens (TAAs), including P1A antigen. Cancer cells can evade the immune system by epigenetic silencing of TAAs, while DNA methyltransferase inhibitors, such as 5-aza-2'-deoxycytidine (5-aza-dC) can restore the expression of silenced or downregulated TAA. Thus, epigenetic remodeling with 5-aza-dC combined with PDT can elicit robust and durable antitumor immunity.
authors: Department of Immunology; Center for Biostructure Research; Medical University of Warsaw; Warsaw, Poland.
authors: Malgorzata
authors: M
authors: Wachowska
authors: Department of Immunology; Center for Biostructure Research; Medical University of Warsaw; Warsaw, Poland.
authors: Magdalena
authors: M
authors: Gabrysiak
authors: Department of Immunology; Center for Biostructure Research; Medical University of Warsaw; Warsaw, Poland ; Institute of Physical Chemistry; Polish Academy of Sciences; Warsaw, Poland.
authors: Jakub
authors: J
authors: Golab
keywords: 5-aza-2’-deoxycitidine; cancer; epigenetic; methyltransferase; photodynamic therapy; tumor immunology; tumor-associated antigens