title: Changes in the pattern of Kaposi's sarcoma at Ocean Road Cancer Institute in Tanzania (2006-2011).
abstract: Tanzania has high human immunodeficiency virus and human herpes virus-8 rates linked to Kaposi's sarcoma. We conducted a study at the Ocean Road Cancer Institute in Dar es Salaam, Tanzania to examine changes in proportions of Kaposi's sarcoma to all cancers over the period (2006-2011) of increased acquired immune deficiency syndrome management by anti-retroviral therapy. We included 1504 Kaposi's sarcoma cases from Ocean Road Cancer Institute and abstracted information regarding age, gender, human immunodeficiency virus and tuberculosis, anti-retroviral therapy duration and Kaposi's sarcoma lesions. Male Kaposi's sarcoma patients (59.6%) were older (42.1 ± 11.5 years) than women (40.4%) (36.2 ± 9.6 years). Kaposi's sarcoma proportions declined from 10.1% in 2003 to 7.4% in 2011. Being a woman was associated with increased oral and generalized lesions and higher numbers of lesion locations (odds ratio [OR] = 2.17, 95% confidence interval [CI]: 1.35, 3.51; OR = 1.49, CI: 1.08, 2.06; OR = 1.06, CI: 0.79, 1.41, respectively). Tuberculosis was associated with oral, generalized and number of lesion locations (OR = 2.08, CI: 1.10, 3.93; OR = 2.06, CI: 1.28, 3.33; OR = 1.88, CI: 1.19, 2.97, respectively). Anti-retroviral therapy duration showed a protective effect with oral, generalized and number of lesion locations (OR = 0.55, CI: 0.33, 0.91; OR = 0.73, CI: 0.52, 1.01; OR = 0.89, CI: 0.67, 1.18, respectively). With increasing number of patients receiving prolonged anti-retroviral therapy, future studies should investigate long-term effect of anti-retroviral therapy and tuberculosis in Tanzania and countries with human immunodeficiency virus infection.
authors: University of Michigan School of Public Health, Ann Arbor USA.
authors: Lia
authors: L
authors: Koski
authors: Ocean Road Cancer Institute, Dar es Salaam, Tanzania.
authors: Twalib
authors: T
authors: Ngoma
authors: Ocean Road Cancer Institute, Dar es Salaam, Tanzania.
authors: Julius
authors: J
authors: Mwaiselage
authors: Department of Epidemiology, College of Public Health, University of Nebraska Medical Center, Omaha, NE, USA.
authors: Lynne
authors: L
authors: Le
authors: Department of Epidemiology, College of Public Health, University of Nebraska Medical Center, Omaha, NE, USA amr.soliman@unmc.edu.
authors: Amr S
authors: AS
authors: Soliman
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology; D000328:Adult; D000368:Aged; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology; D006679:HIV Seropositivity / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012514:Sarcoma, Kaposi / Q000150:complications / Q000453:epidemiology* / Q000473:pathology*; D012959:Socioeconomic Factors; D013636:Tanzania / Q000453:epidemiology; D016896:Treatment Outcome
chemical_list: D019380:Anti-HIV Agents
keywords: AIDS; HHV-8; HIV; Human immunodeficiency virus; Kaposi’s sarcoma; Tanzania; antiretroviral therapy; cancer; human herpes virus-8; trend