title: Bone marrow-derived mesenchymal cell differentiation toward myogenic lineages: facts and perspectives.
abstract: Bone marrow-derived mesenchymal stem cells (BM-MSCs) are valuable platforms for new therapies based on regenerative medicine. BM-MSCs era is coming of age since the potential of these cells is increasingly demonstrated. In fact, these cells give origin to osteoblasts, chondroblasts, and adipocyte precursors in vitro, and they can also differentiate versus other mesodermal cell types like skeletal muscle precursors and cardiomyocytes. In our short review, we focus on the more recent manipulations of BM-MSCs toward skeletal and heart muscle differentiation, a growing field of obvious relevance considering the toll of muscle disease (i.e., muscular dystrophies), the heavier toll of heart disease in developed countries, and the still not completely understood mechanisms of muscle differentiation and repair.
authors: Department of Biomedical, Biotechnological and Translational Sciences (S.Bi.Bi.T.), University of Parma, Via Gramsci 14, 43126 Parma, Italy.
authors: Daniela
authors: 0000-0003-0200-5852
authors: D
authors: Galli
authors: Department of Biomedical, Biotechnological and Translational Sciences (S.Bi.Bi.T.), University of Parma, Via Gramsci 14, 43126 Parma, Italy.
authors: Marco
authors: M
authors: Vitale
authors: Department of Human, Social and Health Sciences, University of Cassino and Southern Lazio, Via Sant'Angelo, Località Folcara snc, 03043 Cassino, Italy ; School of Biomedical Sciences, University of Queensland, Brisbane, QLD 4072, Australia.
authors: Mauro
authors: M
authors: Vaccarezza
mesh_terms: D017667:Adipocytes / Q000166:cytology; D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D019902:Chondrocytes / Q000166:cytology; D002986:Clinical Trials as Topic; D006331:Heart Diseases / Q000473:pathology; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D018482:Muscle, Skeletal / Q000166:cytology / Q000473:pathology; D009135:Muscular Diseases / Q000473:pathology; D010006:Osteoblasts / Q000166:cytology; D044968:Regenerative Medicine