title: Insulin-like growth factor-1 induces regulatory T cell-mediated suppression of allergic contact dermatitis in mice.
abstract: Allergic contact dermatitis (ACD) is triggered by an aberrant hyperinflammatory immune response to innocuous chemical compounds and ranks as the world's most prevalent occupational skin condition. Although a variety of immune effector cells are activated during ACD, regulatory T (Treg) cells are crucial in controlling the resulting inflammation. Insulin-like growth factor-1 (IGF-1) regulates cell proliferation and differentiation and accelerates wound healing and regeneration in several organs including the skin. Recently IGF-1 has also been implicated in protection from autoimmune inflammation by expansion of Treg cells. Here, we demonstrate that ectopic expression of IGF-1 in mouse skin suppresses ACD in a Treg cell-specific manner, increasing the number of Foxp3+ Treg cells in the affected area and stimulating lymphocyte production of the anti-inflammatory cytokine interleukin 10. Similar therapeutic effects can be achieved with systemic or topical delivery of IGF-1, implicating this growth factor as a promising new therapeutic option for the treatment of ACD.
authors: Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), Monterotondo, 00015, Italy.
authors: Bjarki
authors: B
authors: Johannesson
authors: National Heart and Lung Institute, Imperial College, London W12 0NN, UK.
authors: Susanne
authors: S
authors: Sattler
authors: Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), Monterotondo, 00015, Italy.
authors: Ekaterina
authors: E
authors: Semenova
authors: Laboratory of Experimental Immunology, Istituto Dermopatico Immacolata, IRCCS, Rome 00167, Italy.
authors: Saveria
authors: S
authors: Pastore
authors: National Heart and Lung Institute, Imperial College, London W12 0NN, UK.
authors: Teresa M
authors: TM
authors: Kennedy-Lydon
authors: National Heart and Lung Institute, Imperial College, London W12 0NN, UK.
authors: Robert D
authors: RD
authors: Sampson
authors: National Heart and Lung Institute, Imperial College, London W12 0NN, UK.
authors: Michael D
authors: MD
authors: Schneider
authors: Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), Monterotondo, 00015, Italy. National Heart and Lung Institute, Imperial College, London W12 0NN, UK. Australian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800 Australia. nadia.rosenthal@monash.edu.
authors: Nadia
authors: N
authors: Rosenthal
authors: Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), Monterotondo, 00015, Italy.
authors: Daniel
authors: D
authors: Bilbao
mesh_terms: D000818:Animals; D017449:Dermatitis, Allergic Contact / Q000276:immunology* / Q000473:pathology; D004423:Ear / Q000473:pathology; D051858:Forkhead Transcription Factors / Q000378:metabolism; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism* / Q000494:pharmacology; D016753:Interleukin-10 / Q000378:metabolism; D018655:Lymphocyte Count; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D017526:Receptor, IGF Type 1 / Q000378:metabolism; D012867:Skin / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology*
chemical_list: D051858:Forkhead Transcription Factors; C498833:Foxp3 protein, mouse; D016753:Interleukin-10; D007334:Insulin-Like Growth Factor I; D017526:Receptor, IGF Type 1
keywords: Atopic dermatitis; Contact hypersensitivity; Insulin-like growth factor-1; Regulatory T cells; Treg