title: [Comparison of dexmedetomidine and propofol for short-term sedation in early postoperative period after cardiac surgery].
abstract: OBJECTIVE
  To compare the efficacy of Dexmedetomidine and Propofol for short-term controlled sedation and analgesia in the early postoperative period after cardiac surgery.
  
  
  METHODS
  We performed open randomized prospective comparative study in 55 cardiovascular surgery patients. In the early postoperative period 28 patients received infusion of Dexmedetomidine (0.2-0.7 microg/kg per hour) while 27 patients--Propofol (0.3-2(system text of symbol)). Analgesia was carried out with Ketoprofen 100 mg/12h and additional 20 mg of Trimeperidine in case of pain intensity > or = 3 points (5-level verbal pain score). Sedation and agitation level (RASS scale), speed of awakening (Aldrete score), duration of mechanical ventilation and stay in the ICU, need for additional opioid injections, type and frequency of side effects were evaluated.
  
  
  RESULTS
  We didn't find any significant differences in the duration of mechanical ventilation or rate of awakening after the end of infusion between the groups. Dexmedetomidine in the majority of cases resulted in mild or moderate sedation, Propofol--in deeper level of sedation. Retrograde amnesia was reached significantly more often (p < 0.05) in Dexmetomedine group. The daily dose of Trimeperidine in Propofol group was significantly higher (8 mg and 18 mg on average, p = 0.02). Differences in side effects between the groups were noted--bradycardia (Dexmetomedine--10 (39%), Propofol--3 (11%), p = 0.004) arterial hypotension (Dexmetomedine--9 (32%), Propofol--15 (59%), p = 0.002) and general malaise (Dexmetomedine--2 (7%), Propofol--6 (24%), p = 0.001). The length of stay in the ICU in Dexmetomedine group was significantly lower (1,1 days vs 2,6 days respectively, p = 0.006).
  
  
  CONCLUSIONS
  To compare with Propofol Dexmetomedine induces less sedation level and more often provides retrograde amnesia with the same duration of mechanical ventilation and awakening rate. Dexmetomedine provides its own analgesic effect and shortens the length of patient's stay in ICU. Bradycardia was noted more frequently in Dexmedetomidine while arterial hypotension, general malaise and delirium--in Propofol group.
authors: A A
authors: AA
authors: Eremenko
authors: E V
authors: EV
authors: Chemova
mesh_terms: D000700:Analgesics / Q000008:administration & dosage / Q000627:therapeutic use; D006348:Cardiac Surgical Procedures; D016292:Procedural Sedation / Q000379:methods; D020927:Dexmedetomidine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D007362:Intensive Care Units; D007902:Length of Stay; D008297:Male; D010149:Postoperative Pain / Q000188:drug therapy; D011184:Postoperative Period; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011446:Prospective Studies; D012121:Respiration, Artificial / Q000379:methods; D013997:Time Factors
chemical_list: D000700:Analgesics; D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine; D015742:Propofol