title: Association of dietary intake of folate and MTHFR genotype with breast cancer risk.
abstract: We conducted a hospital-based case-control study to investigate the associations of dietary intake of folate and MTHFR C677T and A1298C polymorphisms with breast cancer in a Chinese population. A 1:1-matched case-control study was conducted. Two hundred and thirty patients who were newly diagnosed and histologically confirmed breast cancer and 230 controls were enrolled from Xinxiang Central Hospital. Folate intake was calculated by standard portion size and relative size for each food item in the questionnaire. Genotyping of MTHFR C677T and A1298C was performed by PCR-RFLP. MTHFR 677TT (OR = 2.26, 95%CI = 1.09-4.87, P = 0.02) and T allele (OR = 1.40, 95%CI = 1.03-1.90, P = 0.03) had an increased risk of laryngeal cancer when compared with the CC genotype. We found any interaction between MTHFR C677T and folate intake (P for interaction = 0.02). In conclusion, our study demonstrated that MTHFR C677T polymorphism and folate are associated with risk of breast cancer.
authors: Medical Image Center, Xinxiang Central Hospital, Xinxiang, China wzg_xch@163.com.
authors: Z G
authors: ZG
authors: Wang
authors: Special-Needed Hospital Ward, Xinxiang Central Hospital, Xinxiang, China.
authors: W
authors: W
authors: Cui
authors: Special-Needed Hospital Ward, Xinxiang Central Hospital, Xinxiang, China.
authors: L F
authors: LF
authors: Yang
authors: Health Check Centre, Xinxiang Central Hospital, Xinxiang, China.
authors: Y Q
authors: YQ
authors: Zhu
authors: Special-Needed Hospital Ward, Xinxiang Central Hospital, Xinxiang, China.
authors: W H
authors: WH
authors: Wei
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People; D001943:Breast Neoplasms / Q000208:ethnology / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D004435:Eating / Q000502:physiology; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage / Q000009:adverse effects*; D015870:Gene Expression; D005838:Genotype; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D012307:Risk Factors; D011795:Surveys and Questionnaires
chemical_list: D005492:Folic Acid; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)