title: A Proposal for Six Sigma Integration for Large-Scale Production of Penicillin G and Subsequent Conversion to 6-APA.
abstract: Six Sigma methodology has been successfully applied to daily operations by several leading global private firms including GE and Motorola, to leverage their net profits. Comparatively, limited studies have been conducted to find out whether this highly successful methodology can be applied to research and development (R&D). In the current study, we have reviewed and proposed a process for a probable integration of Six Sigma methodology to large-scale production of Penicillin G and its subsequent conversion to 6-aminopenicillanic acid (6-APA). It is anticipated that the important aspects of quality control and quality assurance will highly benefit from the integration of Six Sigma methodology in mass production of Penicillin G and/or its conversion to 6-APA.
authors: Department of Biotechnology, Jaypee Institute of Information Technology, Noida, Uttar Pradesh 201307, India.
authors: Anirban
authors: A
authors: Nandi
authors: Department of Chemical Engineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.
authors: Sharadwata
authors: 0000-0002-0592-1891
authors: S
authors: Pan
authors: Department of Chemical Engineering, Monash University, Clayton, Victoria 3800, Australia.
authors: Ravichandra
authors: 0000-0003-4092-0170
authors: R
authors: Potumarthi
authors: Department of Chemical and Petroleum Engineering, Curtin University of Technology, 98009 Miri, Sarawak, Malaysia.
authors: Michael K
authors: MK
authors: Danquah
authors: Department of Biotechnology, Jaypee Institute of Information Technology, Noida, Uttar Pradesh 201307, India.
authors: Indira P
authors: 0000-0002-5836-6123
authors: IP
authors: Sarethy