title: [The antiviral activity of the adamantane derivatives against the influenza virus A (H1N1) pdm2009 model in vivo].
abstract: For the first time in vivo, the model of the viral pneumonia in mice was used to study the antiviral activity against influenza A virus (H1N1) pdm09 synthetic derivatives of adamantane series including the amino acid residues and lipoid acid. It was found that the adamantane derivatives with histidine, serine, and lipoid acid could inhibit the rimantadine-resistant strain of the influenza A (H1N1) pdm09. As a result, the lifespan of the mice infected with the virus has increased by 1.6 times with respect to viral control. Thus, the possibility of restoration of antiviral properties of rimantadine both in vitro and in vivo by introducing into its molecular structure new functionally active groups was tested.
authors: M Iu
authors: MIu
authors: Shchelkanov
authors: V A
authors: VA
authors: Shibnev
authors: I T
authors: IT
authors: Finogenova
authors: T M
authors: TM
authors: Fediakina
authors: T M
authors: TM
authors: Garaev
authors: N V
authors: NV
authors: Markova
authors: I M
authors: IM
authors: Kirillov
mesh_terms: D000218:Adamantane / Q000008:administration & dosage* / Q000031:analogs & derivatives; D000818:Animals; D004195:Disease Models, Animal; D024882:Drug Resistance, Viral / Q000235:genetics; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects* / Q000472:pathogenicity; D051379:Mice; D008826:Microbial Sensitivity Tests / Q000379:methods; D011014:Pneumonia / Q000188:drug therapy* / Q000473:pathology / Q000821:virology; D012299:Rimantadine / Q000008:administration & dosage
chemical_list: D012299:Rimantadine; D000218:Adamantane