title: Traditional uses, chemical constituents, and biological activities of Bixa orellana L.: a review.
abstract: Bixa orellana L., popularly known as "urucum," has been used by indigenous communities in Brazil and other tropical countries for several biological applications, which indicates its potential use as an active ingredient in pharmaceutical products. The aim of this work was to report the main evidence found in the literature, concerning the ethnopharmacology, the biological activity, and the phytochemistry studies related to Bixa orellana L. Therefore, this work comprises a systematic review about the use of Bixa orellana in the American continent and analysis of the data collected. This study shows the well-characterized pharmacological actions that may be considered relevant for the future development of an innovative therapeutic agent.
authors: Laboratory of Pharmaceutical Technology, Federal University of Paraíba, 58051-900 João Pessoa, PB, Brazil.
authors: Daniela de Araújo
authors: Dde A
authors: Vilar
authors: Laboratory of Pharmaceutical Technology, Federal University of Paraíba, 58051-900 João Pessoa, PB, Brazil.
authors: Marina Suênia de Araujo
authors: MS
authors: Vilar
authors: Department of Pharmacy, Federal University of Rio Grande do Norte, 59010-180 Natal, RN, Brazil.
authors: Túlio Flávio Accioly
authors: TF
authors: de Lima e Moura
authors: Department of Pharmacy, Federal University of Rio Grande do Norte, 59010-180 Natal, RN, Brazil.
authors: Fernanda Nervo
authors: FN
authors: Raffin
authors: Department of Molecular Biology, Federal University of Paraíba, 58051-900 João Pessoa, PB, Brazil.
authors: Márcia Rosa
authors: MR
authors: de Oliveira
authors: State Company of Agricultural Research of Paraíba, Rua Eurípedes Tavares 210, Tambiá, 58013-290 João Pessoa, PB, Brazil.
authors: Camilo Flamarion de Oliveira
authors: CF
authors: Franco
authors: Department of Chemistry, Federal University of Paraíba, 58051-900 João Pessoa, PB, Brazil.
authors: Petrônio Filgueiras
authors: PF
authors: de Athayde-Filho
authors: Laboratory of Pharmaceutical Technology, Federal University of Paraíba, 58051-900 João Pessoa, PB, Brazil.
authors: Margareth de Fátima Formiga Melo
authors: Mde F
authors: Diniz
authors: Laboratory of Pharmaceutical Technology, Federal University of Paraíba, 58051-900 João Pessoa, PB, Brazil.
authors: José Maria
authors: JM
authors: Barbosa-Filho
mesh_terms: D031212:Bixaceae / Q000737:chemistry*; D008519:Medicine, Traditional; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry; D013020:South America
chemical_list: D010936:Plant Extracts