title: Genetic basis of rheumatoid arthritis: a current review.
abstract: Rheumatoid arthritis (RA) is one of the most common autoimmune diseases. As with other complex traits, genome-wide association studies (GWASs) have tremendously enhanced our understanding of the complex etiology of RA. In this review, we describe the genetic architecture of RA as determined through GWASs and meta-analyses. In addition, we discuss the pathologic mechanism of the disease by examining the combined findings of genetic and functional studies of individual RA-associated genes, including HLA-DRB1, PADI4, PTPN22, TNFAIP3, STAT4, and CCR6. Moreover, we briefly examine the potential use of genetic data in clinical practice in RA treatment, which represents a challenge in medical genetics in the post-GWAS era.
authors: Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan. Electronic address: ykochi@src.riken.jp.
authors: Yuta
authors: Y
authors: Kochi
authors: Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan.
authors: Akari
authors: A
authors: Suzuki
authors: Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan; Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
authors: Kazuhiko
authors: K
authors: Yamamoto
mesh_terms: D001172:Arthritis, Rheumatoid / Q000453:epidemiology* / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics; D055106:Genome-Wide Association Study; D059811:HLA-DRB1 Chains / Q000235:genetics; D006801:Humans; D006867:Hydrolases / Q000235:genetics; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics; D009687:Nuclear Proteins / Q000235:genetics; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22 / Q000235:genetics; D000080002:Protein-Arginine Deiminase Type 4; D000076342:Protein-Arginine Deiminases; D054399:Receptors, CCR6 / Q000235:genetics; D012306:Risk; D050797:STAT4 Transcription Factor / Q000235:genetics; D000072598:Tumor Necrosis Factor alpha-Induced Protein 3
chemical_list: C106311:CCR6 protein, human; D004268:DNA-Binding Proteins; D059811:HLA-DRB1 Chains; D047908:Intracellular Signaling Peptides and Proteins; D009687:Nuclear Proteins; D054399:Receptors, CCR6; D050797:STAT4 Transcription Factor; D006867:Hydrolases; C516765:PTPN22 protein, human; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22; C076529:TNFAIP3 protein, human; D000072598:Tumor Necrosis Factor alpha-Induced Protein 3; C000629235:PADI4 protein, human; D000080002:Protein-Arginine Deiminase Type 4; D000076342:Protein-Arginine Deiminases
keywords: Anti-citrullinated protein antibody; Genome-wide association study; HLA-DRB1; Rheumatoid arthritis