title: Integrative genomic analysis for the discovery of biomarkers in prostate cancer.
abstract: Genome-wide association studies (GWAS) have achieved great success in identifying single nucleotide polymorphisms (SNPs, herein called genetic variants) and genes associated with risk of developing prostate cancer. However, GWAS do not typically link the genetic variants to the disease state or inform the broader context in which the genetic variants operate. Here, we present a novel integrative genomics approach that combines GWAS information with gene expression data to infer the causal association between gene expression and the disease and to identify the network states and biological pathways enriched for genetic variants. We identified gene regulatory networks and biological pathways enriched for genetic variants, including the prostate cancer, IGF-1, JAK2, androgen, and prolactin signaling pathways. The integration of GWAS information with gene expression data provides insights about the broader context in which genetic variants associated with an increased risk of developing prostate cancer operate.
authors: Cancer Institute, University of Mississippi Medical Center, Jackson, MS, USA. ; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA. ; Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS, USA. ; Department of Public Health Sciences, University of Lusaka, Lusaka, Zambia.
authors: Chindo
authors: C
authors: Hicks
authors: Cancer Institute, University of Mississippi Medical Center, Jackson, MS, USA.
authors: Tejaswi
authors: T
authors: Koganti
authors: Cancer Institute, University of Mississippi Medical Center, Jackson, MS, USA.
authors: Shankar
authors: S
authors: Giri
authors: Department of Environmental Sciences, University of South Africa, UNISA Florida Campus, Florida, South Africa.
authors: Memory
authors: M
authors: Tekere
authors: Cancer Institute, University of Mississippi Medical Center, Jackson, MS, USA.
authors: Ritika
authors: R
authors: Ramani
authors: Cancer Institute, University of Mississippi Medical Center, Jackson, MS, USA.
authors: Jitsuda
authors: J
authors: Sitthi-Amorn
authors: Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS, USA.
authors: Srinivasan
authors: S
authors: Vijayakumar
keywords: GWAS; gene expression; genetic variants; prostate cancer