title: [Experimental research of hair follicle reconstruction with the aid of embryonic mice dermal cells].
abstract: OBJECTIVE
  To investigate the effect of embryonic dermal signal on the hair-inductive capacity of neonatal mice dermal cells which have been amplified in vitro.
  
  
  METHODS
  Embryonic mice dermal cells of embryonic day 14 were added to a chamber on the back of nude mice with neonatal mice dermal cells which had been amplified in vitro for 3 days and freshly isolated neonatal mice epidermal cells. The hair regeneration was compared between the groups with or without embryonic mice dermal cells. Meanwhile, chambers with following cells respectively were constructed as controls: embryonic mice dermal cells + neonatal mice epidermal cells; freshly isolated neonatal mice dermal cells + neonatal mice epidermal cells; amplified neonatal mice dermal cells only; embryonic mice dermal cells only; freshly isolated neonatal mice dermal cells only; neonatal mice epidermal cells only.
  
  
  RESULTS
  The number of regenerated hairs with the aid of embryonic mice dermal cells (207 +/- 15. 948) was significantly higher than that (67 +/- 8.963) in the group without embryonic mice dermal cells (n = 3, t = 7.653, P = 0.002).
  
  
  CONCLUSIONS
  Embryonic dermal signal can enhance the hair-inductive capacity of neonatal mice dermal cells which have been amplified in vitro.
authors: Yi-Jue
authors: YJ
authors: Hu
authors: Zhi-Qi
authors: ZQ
authors: Hu
authors: Chuan-Bo
authors: CB
authors: Feng
authors: Yong
authors: Y
authors: Miao
mesh_terms: D000818:Animals; D017690:Cell Transplantation / Q000379:methods; D002478:Cells, Cultured; D006197:Hair / Q000502:physiology*; D018859:Hair Follicle / Q000601:surgery*; D051379:Mice; D008819:Mice, Nude; D019651:Plastic Surgery Procedures; D012038:Regeneration; D012867:Skin / Q000166:cytology / Q000196:embryology