title: Association of obesity with rs1421085 and rs9939609 polymorphisms of FTO gene.
abstract: The aim of this study is to investigate the genetic influence of polymorphisms in fat mass and obesity associated (FTO) gene on a sample of obese subjects and controls. Obesity is an epidemic all over the world. Several polymorphisms in the first intron of FTO gene have been associated with common forms of human obesity. In this research rs1421085 and rs9939609 polymorphisms of FTO gene were genotyped in 190 obese patients with a BMI ≥30 kg/m(2) (Body Mass Index) and 97 healthy controls with a BMI of 18.5-24.9. Genotyping of SNPs was performed by real-time polymerase chain reaction. Body composition was established with bioelectric impedance analysis. Waist-to-hip ratio was determined for all participants. There were no significant differences (P > 0.05) between obese cases and controls in terms of genotype frequencies of rs1421085 and rs9939609 polymorphisms in our study. Also there were no significant correlations between genotypes and obesity related (anthropometric-body composition) parameters (P > 0.05).
authors: Department of Medical Genetics, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey.
authors: Mustafa
authors: M
authors: Solak
authors: Mujgan
authors: M
authors: Ozdemir Erdogan
authors: Saliha Handan
authors: SH
authors: Yildiz
authors: Kagan
authors: K
authors: Ucok
authors: Seref
authors: S
authors: Yuksel
authors: Evrim Suna
authors: ES
authors: Arıkan Terzi
authors: Ahmet
authors: A
authors: Bestepe
mesh_terms: D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D001823:Body Composition / Q000235:genetics / Q000502:physiology; D017097:Electric Impedance; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D009765:Obesity / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011506:Proteins / Q000235:genetics*; D060888:Real-Time Polymerase Chain Reaction; D049629:Waist-Hip Ratio
chemical_list: D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human