title: Association between angiotensin-converting enzyme gene insertion/deletion polymorphism and pancreatitis risk: A meta-analysis.
abstract: OBJECTIVE
  Many studies have focused on the relationship between the angiotensin-converting enzyme gene (ACE) insertion/deletion (I/D) polymorphism and pancreatitis risk, but the results remain inconsistent. Thus, a meta-analysis was carried out to derive a more precise estimation of the association between ACE I/D polymorphism and pancreatitis risk.
  
  
  METHODS
  Relevant publications were searched in several widely used databases and seven studies from six eligible articles were included in the meta-analysis. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the association between ACE I/D polymorphism and pancreatitis risk.
  
  
  RESULTS
  Significant associations between ACE I/D polymorphism and pancreatitis risk were observed in both overall meta-analysis for DI versus II (OR=0.80, 95% CI=0.67-0.96) and DD + DI versus II (OR=0.83, 95% CI=0.70-0.98), and acute pancreatitis subgroup for DI versus II (OR=0.65, 95% CI=0.44-0.95). However, no significant pancreatitis risk variation was detected for all genetic models in the subgroup meta-analysis based on ethnicity.
  
  
  CONCLUSIONS
  According to the results of our meta-analysis, the ACE I/D polymorphism probably associates with pancreatitis risk, especially acute pancreatitis risk, with the I allele acting as a risk factor.
authors: Institute of Pediatric Research, Children's Hospital of Soochow University, China.
authors: Fang
authors: F
authors: Fang
authors: Institute of Pediatric Research, Children's Hospital of Soochow University, China.
authors: Jian
authors: J
authors: Pan
authors: Institute of Pediatric Research, Children's Hospital of Soochow University, China.
authors: Lixiao
authors: L
authors: Xu
authors: Institute of Pediatric Research, Children's Hospital of Soochow University, China.
authors: Guanghao
authors: G
authors: Su
authors: Institute of Pediatric Research, Children's Hospital of Soochow University, China.
authors: Gang
authors: G
authors: Li
authors: Institute of Pediatric Research, Children's Hospital of Soochow University, China wj196312@vip.163.com.
authors: Jian
authors: J
authors: Wang
mesh_terms: D000208:Acute Disease; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D054643:INDEL Mutation / Q000235:genetics*; D008957:Models, Genetic; D010195:Pancreatitis / Q000201:enzymology* / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D017594:Publication Bias; D012307:Risk Factors
chemical_list: C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A
keywords: Angiotensin-converting enzyme; meta-analysis; pancreatitis; polymorphism; risk