title: Regional differences in the incidence of self-reported type 2 diabetes in Germany: results from five population-based studies in Germany (DIAB-CORE Consortium).
abstract: BACKGROUND
  Population-based data are paramount to investigate the long-term course of diabetes, for planning in healthcare and to evaluate the cost-effectiveness of primary prevention. We analysed regional differences in the incidence of self-reported type 2 diabetes mellitus in Germany.
  
  
  METHODS
  Data of participants (baseline age 45-74 years) from five regional population-based studies conducted between 1997 and 2010 were included (mean follow-up 2.2-7.1 years). The incidence of self-reported type 2 diabetes mellitus at follow-up was compared. The incidence rates per 1000 person-years (95% CI) and the cumulative incidence (95% CI) from regional studies were directly standardised to the German population (31 December 2007) and weighted by inverse probability weights for losses to follow-up.
  
  
  RESULTS
  Of 8787 participants, 521 (5.9%) developed type 2 diabetes mellitus corresponding to an incidence rate of 11.8/1000 person-years (95% CI 10.8 to 12.9). The regional incidence was highest in the East and lowest in the South of Germany with 16.9 (95% CI 13.3 to 21.8) vs 9.3 (95% CI 7.4 to 11.1)/1000 person-years, respectively. The incidence increased with age and was higher in men than in women.
  
  
  CONCLUSIONS
  The incidence of self-reported type 2 diabetes mellitus shows regional differences within Germany. Prevention measures need to consider sex-specific differences and probably can be more efficiently introduced toward those regions in need.
authors: Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
authors: Sabine
authors: S
authors: Schipf
authors: Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
authors: Till
authors: T
authors: Ittermann
authors: Institute of Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine-University, Düsseldorf, Germany.
authors: Teresa
authors: T
authors: Tamayo
authors: Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute of Health Economics and Health Care Management, Neuherberg, Germany.
authors: Rolf
authors: R
authors: Holle
authors: Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute of Health Economics and Health Care Management, Neuherberg, Germany.
authors: Michaela
authors: M
authors: Schunk
authors: Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute of Health Economics and Health Care Management, Neuherberg, Germany.
authors: Werner
authors: W
authors: Maier
authors: Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute of Epidemiology II, Neuherberg, Germany German Center for Diabetes Research (DZD), Neuherberg, Germany.
authors: Christine
authors: C
authors: Meisinger
authors: Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute of Epidemiology II, Neuherberg, Germany German Center for Diabetes Research (DZD), Neuherberg, Germany.
authors: Barbara
authors: B
authors: Thorand
authors: Institute of Medical Epidemiology, Biostatistics and Informatics, Martin-Luther-University Halle-Wittenberg, Halle(Saale), Germany.
authors: Alexander
authors: A
authors: Kluttig
authors: Institute of Medical Epidemiology, Biostatistics and Informatics, Martin-Luther-University Halle-Wittenberg, Halle(Saale), Germany Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors: Karin Halina
authors: KH
authors: Greiser
authors: Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany.
authors: Klaus
authors: K
authors: Berger
authors: Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany.
authors: Grit
authors: G
authors: Müller
authors: Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Germany.
authors: Susanne
authors: S
authors: Moebus
authors: Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Germany.
authors: Uta
authors: U
authors: Slomiany
authors: Institute of Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine-University, Düsseldorf, Germany Department of Public Health, Faculty of Medicine, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
authors: Andrea
authors: A
authors: Icks
authors: Institute of Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine-University, Düsseldorf, Germany.
authors: Wolfgang
authors: W
authors: Rathmann
authors: Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany German Center of Cardiovascular Research, Greifswald, Germany.
authors: Henry
authors: H
authors: Völzke
mesh_terms: D017677:Age Distribution; D000368:Aged; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology*; D005260:Female; D005843:Geography; D005858:Germany / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016012:Poisson Distribution; D057566:Self Report; D017678:Sex Distribution
keywords: Cohort studies; Epidemiological methods; Epidemiology of diabetes; GEOGRAPHY