title: Transformation of small B-cell lymphoma into large cell CD30⁺, CD4⁺, Epstein-Barr virus-negative lymphoma.
abstract: We report here 2 separate cases in which patients with known low-grade B-cell lymphomas presented with transformed lesions that were CD30⁺, CD4⁺, Epstein-Barr virus negative, and negative or focally weak for a wide range of B-cell, T-cell, and histiocytic/dendritic cell markers. In each case the transformed lymphoma possessed an identical pattern of immunoglobulin heavy chain and/or BCL2 rearrangement to the corresponding original low-grade B-cell lymphoma, confirming their identity as transformed B-cell lymphoma. A review of the relevant literature reveals that, to our knowledge, no transformed B-cell lymphomas with this immunophenotype have been previously reported, which creates the opportunity for potential errors of diagnosis. These cases highlight the importance of correlation with the patient's history and with molecular genetic results in rendering an accurate diagnosis.
authors: From the Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, Tennessee (Drs Shaver, Vnencak-Jones, Fasig, and Kim); and the Department of Pathology, Cooper University Hospital, Camden, New Jersey (Drs Ma and Schwarting).
authors: Aaron C
authors: AC
authors: Shaver
authors: Ly
authors: L
authors: Ma
authors: Cindy
authors: C
authors: Vnencak-Jones
authors: Roland S
authors: RS
authors: Schwarting
authors: Kristina J
authors: KJ
authors: Fasig
authors: Annette S
authors: AS
authors: Kim
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D001706:Biopsy; D015704:CD4 Antigens / Q000378:metabolism; D002471:Cell Transformation, Neoplastic; D003937:Diagnosis, Differential; D005260:Female; D015322:Gene Rearrangement, B-Lymphocyte; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D006801:Humans; D017730:Ki-1 Antigen / Q000378:metabolism; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D008224:Lymphoma, Follicular / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D017728:Lymphoma, Large-Cell, Anaplastic / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009363:Neoplasm Proteins / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000378:metabolism
chemical_list: D015415:Biomarkers; D015704:CD4 Antigens; D017730:Ki-1 Antigen; D009363:Neoplasm Proteins; D019253:Proto-Oncogene Proteins c-bcl-2