title: Efficient copper-catalyzed trifluoromethylation of aromatic and heteroaromatic iodides: the beneficial anchoring effect of borates.
abstract: Efficient copper-catalyzed trifluoromethylation of aromatic iodides was achieved with TMSCF3 in the presence of trimethylborate. The Lewis acid was used to anchor the in situ generated trifluoromethyl anion and suppress its rapid decomposition. Broad applicability of the new trifluoromethylating reaction was demonstrated in the functionalization of different aromatic and heteroaromatic iodides.
authors: MTA-ELTE "Lendület" Catalysis and Organic Synthesis Research Group, Institute of Chemistry, Eötvös Loránd University , Pázmány Péter stny. 1/a, H-1117 Budapest, Hungary.
authors: Zsombor
authors: Z
authors: Gonda
authors: Szabolcs
authors: S
authors: Kovács
authors: Csaba
authors: C
authors: Wéber
authors: Tamás
authors: T
authors: Gáti
authors: Attila
authors: A
authors: Mészáros
authors: András
authors: A
authors: Kotschy
authors: Zoltán
authors: Z
authors: Novák
mesh_terms: D001881:Borates / Q000737:chemistry / Q000494:pharmacology*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry*; D006847:Hydrocarbons, Iodinated / Q000737:chemistry*; D008745:Methylation; D015394:Molecular Structure; D012821:Silanes / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D001881:Borates; D006845:Hydrocarbons, Fluorinated; D006847:Hydrocarbons, Iodinated; D012821:Silanes; D003300:Copper; C509472:trimethyl(trifluoromethyl)silane