title: Myeloid Kruppel-like factor 2 deficiency exacerbates neurological dysfunction and neuroinflammation in a murine model of multiple sclerosis.
abstract: Cells of the innate immune system are important mediators of multiple sclerosis (MS). We have previously identified Kruppel-like factor 2 (KLF2) as a critical negative regulator of myeloid activation in the setting of bacterial infection and sepsis, but the role of myeloid KLF2 in MS has not been investigated. In this study, myeloid KLF2 deficient mice exhibited more severe neurological dysfunction and increased spinal cord demyelination and neuroinflammation in experimental autoimmune encephalomyelitis. This study represents the first description of a significant role of myeloid KLF2 in neuroinflammation, identifying KLF2 as a potential target for further investigation in patients with MS.
authors: Case Cardiovascular Research Institute, Harrington Heart and Vascular Institute, Department of Medicine, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
authors: Hong
authors: H
authors: Shi
authors: Case Cardiovascular Research Institute, Harrington Heart and Vascular Institute, Department of Medicine, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
authors: Baiyang
authors: B
authors: Sheng
authors: Case Cardiovascular Research Institute, Harrington Heart and Vascular Institute, Department of Medicine, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
authors: Chao
authors: C
authors: Zhang
authors: Division of Hematology and Oncology, Department of Medicine, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
authors: Lalitha
authors: L
authors: Nayak
authors: Case Cardiovascular Research Institute, Harrington Heart and Vascular Institute, Department of Medicine, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
authors: Zhiyong
authors: Z
authors: Lin
authors: Case Cardiovascular Research Institute, Harrington Heart and Vascular Institute, Department of Medicine, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
authors: Mukesh K
authors: MK
authors: Jain
authors: Case Cardiovascular Research Institute, Harrington Heart and Vascular Institute, Department of Medicine, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA. Electronic address: brandon.atkins@case.edu.
authors: G Brandon
authors: GB
authors: Atkins
mesh_terms: D000818:Animals; D003711:Demyelinating Diseases / Q000235:genetics / Q000276:immunology / Q000473:pathology; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D051741:Kruppel-Like Transcription Factors / Q000235:genetics* / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D051379:Mice; D018345:Mice, Knockout; D009103:Multiple Sclerosis / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D013116:Spinal Cord / Q000276:immunology / Q000473:pathology
chemical_list: C498314:Klf2 protein, mouse; D051741:Kruppel-Like Transcription Factors
keywords: Demyelination; Experimental autoimmune encephalomyelitis; KLF2; Macrophage; Multiple sclerosis; Neuroinflammation