title: Hypothermia as a clinical neuroprotectant.
abstract: Applying therapeutic hypothermia (TH) for the purposes of neuroprotection, originally termed "hibernation," started nearly 100 years ago. Because TH cooling systems have improved to the point where it is practical and safe for general application, interest in providing such treatment in conditions such as spinal cord injury, traumatic brain injury, stroke, and cardiac arrest has increased. This article reviews the mechanisms by which TH mitigates secondary neurologic injury, the clinical scenarios where TH is being applied, and reviews selected published studies using TH for central nervous system neuroprotection.
authors: Department of Physical medicine and Rehabilitation, University of Miami Miller School of Medicine, 1611 Northwest 12th Avenue, 9th Floor, Miami, FL 33136, USA. Electronic address: asherman@med.miami.edu.
authors: Andrew L
authors: AL
authors: Sherman
authors: Department of Neurological Surgery, University of Miami Miller School of Medicine, 1095 Northwest, 14th Terrace, Miami, FL 33136, USA.
authors: Michael Y
authors: MY
authors: Wang
mesh_terms: D000818:Animals; D001831:Body Temperature; D001833:Body Temperature Regulation / Q000502:physiology; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods; D023421:Models, Animal; D018579:Patient Selection; D013119:Spinal Cord Injuries / Q000150:complications* / Q000628:therapy*; D013345:Subarachnoid Hemorrhage / Q000628:therapy
keywords: ASIA score; Hypothermia; Methylprednisolone; Neuroprotection; Spinal cord injury; Trauma