title: The diagnosis and treatment of brain metastases in EGFR mutant lung cancer.
abstract: The epidemiology of non-small-cell lung cancer (NSCLC) has changed with a new pattern of disease emerging - a form of adenocarcinoma in mostly younger female patients, who are never or light smokers and more frequently in East Asian populations. Description of EGF receptor (EGFR) mutations has allowed new management strategies to evolve. Oral targeted therapies have broadened the treatment options in the advanced setting with the potential for periods of long term response. The brain is a common site of metastases with EGFR mutated lung cancer typically displaying asymptomatic, small volume, multiple lesions that respond to treatment. We explore the role of local and system therapies for brain metastases in this disease including the role of EGFR inhibitors.
authors: Royal Marsden Hospital, Sutton, SM2 5PT, UK.
authors: Anna
authors: A
authors: Minchom
authors: Ken C
authors: KC
authors: Yu
authors: Jaishree
authors: J
authors: Bhosle
authors: Mary
authors: M
authors: O'Brien
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000556:secondary* / Q000628:therapy; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics / Q000473:pathology*; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy / Q000379:methods; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D066246:ErbB Receptors / Q000037:antagonists & inhibitors / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000473:pathology*; D009154:Mutation
chemical_list: D004791:Enzyme Inhibitors; C512478:EGFR protein, human; D066246:ErbB Receptors