title: Rh(III)-catalyzed intramolecular redox-neutral or oxidative cyclization of alkynes: short, efficient synthesis of 3,4-fused indole skeletons.
abstract: A Rh(III)-catalyzed intramolecular redox-neutral or oxidative annulation of a tethered alkyne has been developed to efficiently construct 3,4-fused indoles via a C-H activation pathway. The advantages of this process are (1) ready availability of annulation precursors; (2) broad substrate scope; (3) complete regioselectivity; (4) simple and mild reaction conditions; and (5) no need for an external oxidant or to employ molecular oxygen as the stoichiometric terminal oxidant.
authors: Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zu Chong Zhi Road, Shanghai 201203, PR China.
authors: Bing
authors: B
authors: Zhou
authors: Yaxi
authors: Y
authors: Yang
authors: Huanyu
authors: H
authors: Tang
authors: Juanjuan
authors: J
authors: Du
authors: Huijin
authors: H
authors: Feng
authors: Yuanchao
authors: Y
authors: Li
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D010084:Oxidation-Reduction; D012238:Rhodium / Q000737:chemistry*
chemical_list: D000480:Alkynes; D007211:Indoles; D012238:Rhodium