title: Cladosins F and G, two new hybrid polyketides from the deep-sea-derived Cladosporium sphaerospermum 2005-01-E3.
abstract: Two new fungal hybrid polyketides, cladosins F (1) and G (2), with rare 6(3)-enamino-8,10-dihydroxy-tetraketide system were discovered from the deep-sea-derived fungus Cladosporium sphaerospermum 2005-01-E3 guided by OSMAC approach. Their structures were elucidated on the basis of comprehensive spectroscopic analyses, and cytotoxicity, antitubercular, anti-influenza A H1N1 virus, and NF-κB inhibitory activities were evaluated.
authors: a Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003 , China.
authors: Gui-Hong
authors: GH
authors: Yu
authors: Guang-Wei
authors: GW
authors: Wu
authors: Tian-Jiao
authors: TJ
authors: Zhu
authors: Qian-Qun
authors: QQ
authors: Gu
authors: De-Hai
authors: DH
authors: Li
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002963:Cladosporium / Q000737:chemistry*; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects; D008386:Marine Biology; D015394:Molecular Structure; D016328:NF-kappa B / Q000037:antagonists & inhibitors; D019906:Nuclear Magnetic Resonance, Biomolecular; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000995:Antitubercular Agents; D000998:Antiviral Agents; D016328:NF-kappa B; D061065:Polyketides; C000598550:cladosin F; C000598551:cladosin G
keywords: Cladosporium sphaerospermum; cladosin; deep-sea-derived fungus; fungal hybrid polyketide