title: Association of peroxisome proliferator-activated receptor-delta polymorphisms with sugar metabolism indices and tumor necrosis factor alpha level.
abstract: This study aims to investigate the association of peroxisome proliferator-activated receptor (PPAR) delta -87T/C polymorphism with several sugar metabolism indices and tumor necrosis factor α (TNF α) level. The body mass index (BMI), waist size, and levels of fasting plasma glucose, serum lipid, fasting insulin, TNFα, and PPAR delta -87T/C of 286 patients with type 2 diabetes mellitus (T2DM) and 158 subjects with normal fasting glucose (NFG) were measured in a Dalian population. The distribution of genotypic frequencies between T2DM and NFG were not significantly different (χ(2) = 0.012, P = 0.994). BMI, fasting blood glucose (FBG), homeostasis model assessment-estimated insulin resistance (HOMA-IR), triglyceride, and TNFα levels were significantly different among different T2DM genotypes. HOMA-IR and FBG were significantly different among different NFG genotypes. The PPAR delta -87T/C polymorphism is known to be closely related with glucose levels and lipid metabolism. A close relationship was also found between HOMA-IR and TNFα levels and HOMA-IR and FBG in T2DM and NFG, respectively.
authors: Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
authors: X J
authors: XJ
authors: Yu
authors: The Second Hospital of Dalian Medical University, Dalian, China yxj_y@sina.com.
authors: B L
authors: BL
authors: Su
authors: Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
authors: X M
authors: XM
authors: Wang
authors: Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
authors: H J
authors: HJ
authors: Feng
authors: Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
authors: C J
authors: CJ
authors: Jin
mesh_terms: D000368:Aged; D000483:Alleles; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D005215:Fasting; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D047494:PPAR delta / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D014280:Triglycerides / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics* / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D007328:Insulin; D047494:PPAR delta; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha