title: Catalytic methylation of C-H bonds using CO₂ and H₂.
abstract: Formation of C-C bonds from CO2 is a much sought after reaction in organic synthesis. To date, other than C-H carboxylations using stoichiometric amounts of metals, base, or organometallic reagents, little is known about C-C bond formation. In fact, to the best of our knowledge no catalytic methylation of C-H bonds using CO2 and H2 has been reported. Described herein is the combination of CO2 and H2 for efficient methylation of carbon nucleophiles such as indoles, pyrroles, and electron-rich arenes. Comparison experiments which employ paraformaldehyde show similar reactivity for the CO2/H2 system.
authors: Leibniz-Institut für Katalyse e.V. Albert-Einstein-Strasse 29a, 18059 Rostock (Germany) http://www.catalysis.de.
authors: Yuehui
authors: Y
authors: Li
authors: Tao
authors: T
authors: Yan
authors: Kathrin
authors: K
authors: Junge
authors: Matthias
authors: M
authors: Beller
keywords: CH activation; carbon dioxide; heterocycles; hydrogen; ruthenium