title: Case report of a metachronous multiple tumor: mantle cell lymphoma in the orbital region associated with epithelial malignancies at other sites.
abstract: Here we report the case of a 73-year-old man who was diagnosed with metachronous, multiple primary tumors with non-Hodgkin B-cell mantle cell lymphoma involving the orbit on the basis of biopsy and immunohistochemistry in 2012. The patient had been diagnosed with non-Hodgkin small cell lymphoma and basal cell skin carcinoma in 2010 and intestinal adenocarcinoma with metastasis to the regional lymph nodes in 2011, thus representing a typical case of metachronous, multiple primary tumors. Mantle cell lymphoma is a rare disease and its prognosis is quite poor, particularly when it is associated with other metachronous malignancies. Therefore, physicians should consider mantle cell lymphoma as a differential diagnosis for neoplasms of the orbit.
authors: Juliana S F
authors: JS
authors: Medrado
authors: Mirtha Ramírez
authors: MR
authors: Dittrich
authors: Jacqueline M
authors: JM
authors: Sousa
authors: Luiz F
authors: LF
authors: Teixeira
authors: Paulo Góis
authors: PG
authors: Manso
mesh_terms: D000368:Aged; D001706:Biopsy; D006801:Humans; D007150:Immunohistochemistry; D016393:Lymphoma, B-Cell / Q000473:pathology*; D020522:Lymphoma, Mantle-Cell / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D009918:Orbital Neoplasms / Q000473:pathology*