title: Anti-Müllerian hormone as an ovarian reserve marker in young cancer women who undergo ovarian tissue cryopreservation.
abstract: OBJECTIVE
  To evaluate if anti-Müllerian hormone (AMH) is a reliable marker of ovarian reserve in young women undergoing ovarian tissue cryopreservation.
  
  
  METHODS
  Relationships of serum AMH levels with primordial follicle density, age and reproductive hormones were investigated using the Pearson or Spearman correlation coefficient in 86 women with cancer (12-38 years) undergoing ovarian tissue cryopreservation. AMH variations through the menstrual cycle were assessed by the Kruskal-Wallis test. p < 0.05 was accepted as significant.
  
  
  RESULTS
  AMH positively correlated with primordial follicle density (p = 0.03), showed great interindividual variability at all ages and negatively correlated with estradiol (p = 0.007) in the early follicular phase. AMH did not vary across the menstrual cycle (p = 0.415).
  
  
  CONCLUSIONS
  AMH appears a valid ovarian reserve marker in young cancer women.
authors: Department of Medical & Surgical Sciences (DIMEC), Gynecology & Pathophysiology of Human Reproduction Unit, University of Bologna, Sant'Orsola-Malpighi Hospital, Bologna, Italy.
authors: Raffaella
authors: R
authors: Fabbri
authors: Maria
authors: M
authors: Macciocca
authors: Cristina
authors: C
authors: Melotti
authors: Gianandrea
authors: G
authors: Pasquinelli
authors: Rossella
authors: R
authors: Vicenti
authors: Maria Letizia
authors: ML
authors: Bacchi Reggiani
authors: Daniela
authors: D
authors: Terribile
authors: Stefano
authors: S
authors: Venturoli
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D054304:Anti-Mullerian Hormone / Q000097:blood / Q000378:metabolism*; D015415:Biomarkers; D002648:Child; D015925:Cryopreservation; D005260:Female; D042341:Gonadal Hormones / Q000097:blood; D006801:Humans; D008597:Menstrual Cycle; D009369:Neoplasms; D006080:Ovarian Follicle / Q000166:cytology; D065851:Ovarian Reserve; D010053:Ovary / Q000166:cytology; D055815:Young Adult
chemical_list: D015415:Biomarkers; D042341:Gonadal Hormones; D054304:Anti-Mullerian Hormone
keywords: anti-Müllerian hormone; menstrual cycle; ovarian reserve; ovarian tissue cryopreservation; primordial follicles