title: Prospective and episodic memory in relation to hippocampal volume in adults with spina bifida myelomeningocele.
abstract: The present study examined prospective and episodic memory in relation to age, functional independence, and hippocampal volume in younger to middle-aged adults with spina bifida myelomeningocele (SBM) and typically developing (TD) adults. Prospective and episodic memory, as well as hippocampal volume, was reduced in adults with SBM relative to TD adults. Neither memory performance nor hippocampal volume showed greater decrements in older adults. Lower hippocampal volume was associated with reduced prospective memory in adults with SBM, and this relation was specific to the hippocampus and not to a contrast structure, the amygdala. Prospective memory mediated the relation between hippocampal volume and functional independence in adults with SBM. The results add to emerging evidence for reduced memory function in adults with SBM and provide quantitative evidence for compromised hippocampal macrostructure as a neural correlate of reduced memory in this population.
authors: Department of Psychology, University of Houston.
authors: Amery
authors: A
authors: Treble-Barna
authors: Department of Pediatrics, Children's Learning Institute, University of Texas Health Science Center at Houston.
authors: Jenifer
authors: J
authors: Juranek
authors: Texas Institute for Measurement, Evaluation, and Statistics, University of Houston.
authors: Karla K
authors: KK
authors: Stuebing
authors: Department of Psychology, University of Houston.
authors: Paul T
authors: PT
authors: Cirino
authors: Program in Neurosciences and Mental Health, Department of Psychology, The Hospital for Sick Children.
authors: Maureen
authors: M
authors: Dennis
authors: Department of Psychology, University of Houston.
authors: Jack M
authors: JM
authors: Fletcher
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D005260:Female; D006624:Hippocampus / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D057187:Independent Living; D008569:Memory Disorders / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D061212:Memory, Episodic; D008591:Meningomyelocele / Q000209:etiology* / Q000473:pathology / Q000523:psychology; D008875:Middle Aged; D009929:Organ Size; D016135:Spinal Dysraphism / Q000150:complications* / Q000473:pathology / Q000523:psychology