title: An NDT study of a boron tracedrug UTX-51 for glycated BSA as an AGE model.
abstract: BACKGROUND
  Conventional therapies for diseases that are associated with protein aggregation typically prevent rather than clear protein aggregates. We have proposed neutron dynamic therapy (NDT) as a physical clearance therapy for protein aggregates. Advanced glycation end-products (AGEs), which are aggregated proteins, have been implicated in diabetes, Alzheimer's, and heart disease. Herein, we report the use of the boron tracedrug UTX-51, under thermal neutron irradiation, as an NDT for the targeted clearance of glycated bovine serum albumin (Gly-BSA), a model of AGEs.
  
  
  METHODS
  Sodium dodecyl sulfate-polyacrylamide gel electrophoresis was performed to detect Gly-BSA decomposition by thermal neutron irradiation treated with UTX-51.
  
  
  RESULTS
  The combination of UTX-51 with neutron irradiation showed a decrease in band intensity of Gly-BSA.
  
  
  CONCLUSIONS
  We present our NDT strategy, which has been used for the targeted clearance of Gly-BSA, suggesting that NDT with boron tracedrugs can be used for the treatment of AGEs-related disease.
authors: Department of Life System, Institute of Technology and Science, Graduate School, The University of Tokushima, Tokushima, Japan.
authors: Ryu
authors: R
authors: Tada
authors: Department of Life System, Institute of Technology and Science, Graduate School, The University of Tokushima, Tokushima, Japan hori@bio.tokushima-u.ac.jp hitoshi.hori@gmail.com uto@bio.tokushima-u.ac.jp.
authors: Yoshihiro
authors: Y
authors: Uto
authors: Research Reactor Institute, Kyoto University, Kumatoricho, Osaka, Japan.
authors: Shin-Ichiro
authors: S
authors: Masunaga
authors: Research Reactor Institute, Kyoto University, Kumatoricho, Osaka, Japan.
authors: Yuko
authors: Y
authors: Kinashi
authors: Research Reactor Institute, Kyoto University, Kumatoricho, Osaka, Japan.
authors: Koji
authors: K
authors: Ono
authors: Department of Life System, Institute of Technology and Science, Graduate School, The University of Tokushima, Tokushima, Japan hori@bio.tokushima-u.ac.jp hitoshi.hori@gmail.com uto@bio.tokushima-u.ac.jp.
authors: Hitoshi
authors: H
authors: Hori
mesh_terms: D001896:Boron Compounds / Q000627:therapeutic use*; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D012710:Serum Albumin, Bovine / Q000378:metabolism*
chemical_list: D001896:Boron Compounds; D017127:Glycation End Products, Advanced; D012710:Serum Albumin, Bovine
keywords: AGEs; Gly-BSA; Neutron dynamic therapy; UTX-51; boron tracedrug; curcuminoid