title: Ameliorating Effect of Mycoleptodonoides aitchisonii on High-fat Diet-induced Obese Mice.
abstract: The present study investigated the anti-obesity effects of Mycoleptodonoides aitchisonii (MA) in mice fed a high-fat (HF) diet. Two groups were fed either a normal control diet or an HF (45% kcal fat) diet for 12 weeks and three groups were fed an HF diet supplemented with powdered MA (MAP, 1%, 3%, and 5%) for 12 weeks. The anti-obesity effects of MAP supplementation on body weight, fat mass development, and lipid-related markers were assessed. Consumption of an HF diet resulted in increased body weight, serum lipids, relative adipose tissues weight, and liver fat accumulation. However, administration of MAP significantly decreased body weight gain, food intake, food efficiency ratio, hepatic cholesterol level, and adipose tissue weight in a dose-dependent manner. In addition, treatment with MAP significantly reduced the occurrence of fatty liver deposits and steatosis, and inhibited an HF diet-induced increase in adipocyte size. These results suggest that dietary supplementation with MAP exerts anti-obesity effects and indicate that MAP could be used as a functional food to control obesity.
authors: Department of Food Science and Technology, Chungnam National University, Daejeon 305-764, Korea.
authors: Mi Ra
authors: MR
authors: Lee
authors: Department of Food Science and Technology, Chungnam National University, Daejeon 305-764, Korea.
authors: Shahnaz
authors: S
authors: Begum
authors: Jeollanam-do Forest Resource Research Institute, Jeonnam 520-833, Korea.
authors: Deuk Sil
authors: DS
authors: Oh
authors: Jeollanam-do Forest Resource Research Institute, Jeonnam 520-833, Korea.
authors: An Jin
authors: AJ
authors: Wee
authors: Jeollanam-do Forest Resource Research Institute, Jeonnam 520-833, Korea.
authors: Byung Sun
authors: BS
authors: Yun
authors: Department of Food Science and Technology, Chungnam National University, Daejeon 305-764, Korea.
authors: Chang Keun
authors: CK
authors: Sung
keywords: Mycoleptodonoides aitchisonii; adipocyte; high-fat diet; obesity