title: Effect of local endometrial injury on pregnancy outcomes in ovum donation cycles.
abstract: OBJECTIVE
  To evaluate the effect of local endometrial injury (LEI) on clinical outcomes in ovum donation recipients.
  
  
  METHODS
  Retrospective cohort analysis of ovum donation cycles conducted from 2005 to 2012.
  
  
  METHODS
  Two private IVF centers.
  
  
  METHODS
  Total 737 ovum donation cycles.
  
  
  METHODS
  LEI by endometrial "scratch" with the use of a Pipelle catheter.
  
  
  METHODS
  Clinical pregnancy and live birth rates.
  
  
  RESULTS
  No statistically significant differences were found in clinical pregnancy rates and live birth rates in cycles subjected to LEI compared with those without. Combination of LEI with fibroid uterus resulted with significantly higher clinical pregnancy rates compared with LEI in normal uterine anatomy.
  
  
  CONCLUSIONS
  This is the first study done in ovum recipients who underwent LEI by a "scratch" procedure after failed implantation. Unlike most previous reports, which found improved pregnancy rates with the use of "scratch effect" or "minor endometrial injury" after repeated implantation failures in standard IVF with own eggs, we did not find any changes in implantation rates in a population of egg recipients following this procedure. In view of a possible positive effect of LEI in cycles with a previous four or more failures, prospective randomized controlled studies are warranted to better define the target population who may benefit from this intervention.
authors: Division of Fertility-In Vitro Fertilization, Department of Obstetrics and Gynecology, Carmel Medical Center, Faculty of Medicine, Technion, Haifa, Israel.
authors: Lena
authors: L
authors: Dain
authors: St. Georges Hospital, London, United Kingdom; London Bridge Gynecology Fertility and Genetic Centre, London, United Kingdom.
authors: Kamal
authors: K
authors: Ojha
authors: Division of Fertility-In Vitro Fertilization, Sheba Medical Center, Faculty of Medicine, Tel Aviv, Israel.
authors: David
authors: D
authors: Bider
authors: Division of Fertility-In Vitro Fertilization, Sheba Medical Center, Faculty of Medicine, Tel Aviv, Israel.
authors: Jacob
authors: J
authors: Levron
authors: In Vitro Fertilization Center, Isida, Kiev, Ukraine.
authors: Viktor
authors: V
authors: Zinchenko
authors: London Bridge Gynecology Fertility and Genetic Centre, London, United Kingdom.
authors: Sharon
authors: S
authors: Walster
authors: Division of Fertility-In Vitro Fertilization, Department of Obstetrics and Gynecology, Carmel Medical Center, Faculty of Medicine, Technion, Haifa, Israel. Electronic address: dirnfeld_martha@clalit.org.il.
authors: Martha
authors: M
authors: Dirnfeld
mesh_terms: D000328:Adult; D010064:Embryo Implantation; D004624:Embryo Transfer; D004717:Endometrium / Q000293:injuries* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007246:Infertility / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D050498:Live Birth; D008875:Middle Aged; D018587:Oocyte Donation / Q000009:adverse effects; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D014945:Wound Healing; D055815:Young Adult
keywords: Repeated implantation failure; endometrial scratch; local endometrial injury; ovum donation; uterine factors