title: Anti-inflammatory effects of ozonated water in an experimental mouse model.
abstract: Previous studies have suggested that ozonated water is safe and possesses antibacterial effects for treatment of experimental peritonitis rats. In this study, we evaluated the anti-inflammatory effects of ozonated water that was intraperitoneally injected into an experimental inflammatory mouse model. The concentrations of dissolved ozone decreased constantly and lineally, while the half-life of dissolved ozone was 36.8±2.7 min (27°C). The 10-ppm ozonated water was injected intraperitoneally into mice with lipopolysaccharide (LPS)-induced acute inflammation. The results showed that the intraperitoneal injection of ozonated water decreased the levels of tumor necrosis factor-α (TNF-α) and increased the activity of superoxide dismutase (SOD). The results suggest that ozonated water has anti-inflammatory properties and is a potential therapeutic option for acute inflammation.
authors: Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan.
authors: Kazuo
authors: K
authors: Azuma
authors: Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan.
authors: Takuro
authors: T
authors: Mori
authors: Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan.
authors: Kinya
authors: K
authors: Kawamoto
authors: Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan.
authors: Kohei
authors: K
authors: Kuroda
authors: Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan.
authors: Takeshi
authors: T
authors: Tsuka
authors: Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan.
authors: Tomohiro
authors: T
authors: Imagawa
authors: Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan.
authors: Tomohiro
authors: T
authors: Osaki
authors: Sakuragawa Pump Co., Ltd., Osaka 567-0005, Japan.
authors: Fumio
authors: F
authors: Itoh
authors: Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan.
authors: Saburo
authors: S
authors: Minami
authors: Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan.
authors: Yoshiharu
authors: Y
authors: Okamoto
keywords: anti-inflammatory; mouse; ozonated water; tumor necrosis factor-α