title: Renal leukocyte chemotactic factor 2 (LECT2) amyloidosis in First Nations people in Northern British Columbia, Canada: a report of 4 cases.
abstract: Leukocyte chemotactic factor 2 (LECT2) amyloidosis is a recently identified type of amyloidosis that may represent an underdiagnosed cause of chronic kidney disease. LECT2 amyloidosis typically is reported as being renal limited and, in the United States, more prevalent in Hispanic patients. We add to the epidemiologic data of this condition by describing 4 First Nations people from Northern British Columbia, Canada, who presented with slowly progressive chronic kidney disease that was found to be due to LECT2 amyloidosis.
authors: Division of Nephrology, University of British Columbia, Vancouver, BC, Canada. Electronic address: holly.hutton@monash.edu.
authors: Holly L
authors: HL
authors: Hutton
authors: Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
authors: Mari L
authors: ML
authors: DeMarco
authors: Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
authors: Alex B
authors: AB
authors: Magil
authors: Division of Nephrology, University of British Columbia, Vancouver, BC, Canada.
authors: Paul
authors: P
authors: Taylor
mesh_terms: D000368:Aged; D000686:Amyloidosis / Q000175:diagnosis* / Q000208:ethnology / Q000235:genetics*; D001955:British Columbia / Q000208:ethnology; D005260:Female; D006801:Humans; D007198:Indians, North American / Q000208:ethnology / Q000235:genetics*; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis* / Q000208:ethnology / Q000235:genetics*
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; C103468:LECT2 protein, human
keywords: First Nations; Leukocyte chemotactic factor 2 (LECT2); North American indigenous ancestry; amyloid; amyloidosis; chronic kidney disease (CKD); chronic renal failure