title: Identification of Candidate Genes Associated with Beef Marbling Using QTL and Pathway Analysis in Hanwoo (Korean Cattle).
abstract: Marbling from intramuscular fat is an important trait of meat quality and has an economic benefit for the beef industry. Quantitative trait loci (QTL) fine mapping was performed to identify the marbling trait in 266 Hanwoo steers using a 10K single nucleotide polymorphism panel with the combined linkage and linkage disequilibrium method. As a result, we found nine putative QTL regions for marbling: three on BTA6, two on BTA17, two on BTA22, and two on BTA29. We detected candidate genes for marbling within 1 cM of either side of the putative QTL regions. Additionally, to understand the functions of these candidate genes at the molecular level, we conducted a functional categorization using gene ontology and pathway analyses for those genes involved in lipid metabolism or fat deposition. In these putative QTL regions, we found 95 candidate genes for marbling. Using these candidate genes, we found five genes that had a direct interaction with the candidate genes. We also found SCARB1 as a putative candidate gene for marbling that involves fat deposition related to cholesterol transport.
authors: Division of Animal Genomics and Bioinformatics, National Institute of Animal Science, Rural Development Administration, Chuksan gil 77, Kwonsun-gu, Suwon, Korea ; Department of animal biosystem science, Chung-nam National University, 99 Daehak-ro(St), Yuseong-gu, Daejeon, 305-764, Korea .
authors: Hyesun
authors: H
authors: Park
authors: Department of animal biosystem science, Chung-nam National University, 99 Daehak-ro(St), Yuseong-gu, Daejeon, 305-764, Korea .
authors: Seongwon
authors: S
authors: Seo
authors: Green growth and future strategy team, Director general for planning and coordination, Rural Development Administration, Suwon, Korea .
authors: Yong Min
authors: YM
authors: Cho
authors: Division of Animal Genomics and Bioinformatics, National Institute of Animal Science, Rural Development Administration, Chuksan gil 77, Kwonsun-gu, Suwon, Korea.
authors: Sung Jong
authors: SJ
authors: Oh
authors: Division of Animal Genomics and Bioinformatics, National Institute of Animal Science, Rural Development Administration, Chuksan gil 77, Kwonsun-gu, Suwon, Korea.
authors: Hwan-Hoo
authors: HH
authors: Seong
authors: Division of Animal Genomics and Bioinformatics, National Institute of Animal Science, Rural Development Administration, Chuksan gil 77, Kwonsun-gu, Suwon, Korea.
authors: Seung Hwan
authors: SH
authors: Lee
authors: Division of Animal Genomics and Bioinformatics, National Institute of Animal Science, Rural Development Administration, Chuksan gil 77, Kwonsun-gu, Suwon, Korea.
authors: Dajeong
authors: D
authors: Lim
keywords: Hanwoo; Marbling; QTL Fine Mapping