title: [Expression of miR-224 in diffuse large B cell lymphoma and its clinical significance].
abstract: OBJECTIVE
  To investigate the expression of miR-224 in diffuse large B cell lymphoma (DLBCL) and its relationship with clinical pathological features and prognosis.
  
  
  METHODS
  Real-time PCR was used to detect the expression of miR-224 in 168 DLBCL and 25 normal lymphoid tissues.
  
  
  RESULTS
  The expression of miR-224 in DLBCL (0.97 ± 0.33) was significantly lower than that in normal lymphoid tissues (1.87 ± 0.43, P<0.05). There were no significant correlations between the miR-224 expression and age (P=0.434), gender (P=0.613) tumors stage (P=0.250), IPI (P=0.355) and lactate dehydrogenase (P=0.398). Using the median of miRNA-224 expression as threshold, we subdivided patients into low and high expression group. The five-year progression-free survival and overall survival were significantly lower in low expression group as compared to those in high expression group.
  
  
  CONCLUSIONS
  miR-224 expression may play an important role in the development and progression of DLBCL and could be prognostic significance.
authors: Southeast University School of Medical, Nanjing 210009, China.
authors: Guoqi
authors: G
authors: Song
authors: Southeast University School of Medical, Nanjing 210009, China.
authors: Ling
authors: L
authors: Gu
authors: Southeast University School of Medical, Nanjing 210009, China.
authors: Bangshun
authors: B
authors: He
authors: Southeast University School of Medical, Nanjing 210009, China.
authors: Yuqin
authors: Y
authors: Pan
authors: Southeast University School of Medical, Nanjing 210009, China.
authors: Shukui
authors: S
authors: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000378:metabolism* / Q000473:pathology; D008297:Male; D035683:MicroRNAs / Q000378:metabolism*; D008875:Middle Aged; D011379:Prognosis; D055815:Young Adult
chemical_list: C546140:MIRN224 microRNA, human; D035683:MicroRNAs